louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02404948: PRV-based Detection of CAD in Comparison to Standard Methods
Official title: Comparison of a Pulse Wave Based Approach for Detection of Coronary Artery Disease Compared to Standard Methods
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronary Artery Disease
Keywords: coronary artery disease
diagnosis
non-invasive
Lead sponsor: University Medicine Greifswald
Sponsor class: OTHER
First posted: 2015-04-01
Enrollment: 156
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects referred to first coronary angiography due to suspected CAD

Brief summary: This is a validation study comparing a pulse wave based algorithm for the detection of coronary artery disease with parameters from coronary angiography, echocardiography and cardiogoniometry.

Detailed description: The study will validate a pulse wave based algorithm for the detection of coronary artery disease (CAD) with parameters from standard methods. Subjects will be patients admitted to coronary angiography due to suspected CAD. Pulse wave signals will be analyzed according to novelly established algorithm regarding the presence of CAD and/or myocardial ischemia. These results be compared to the diagnoses made by coronary angiography (primary endpoint): presence of minimum one coronary artery stenose \>=50%. For secondary analyses, results will be compared to parameters form echocardiography and cardiogoniometry.

Eligibility criteria: Inclusion Criteria:

* Coronary angiography indication present
* informed written consent

Exclusion Criteria:

* Previous coronary angiography
* Known CAD (history of coronary angioplasty, stent implantation and/or bypass surgery)
* atrial fibrillation (at time of measurement)
* severe ventricular extrasystole (e.g. \>=10% ventricular extrasystoles, bigemina)
* pregnancy, lactation

Primary outcomes:
measure: Presence of CAD - angio (minimum 1 stenosis >=50%)
timeFrame: 1 day
Secondary outcomes:
measure: Presence of CAD number - angio (Number of coronary vessels with at least 1 stenosis >=50% in coronary angiography)
timeFrame: 1 day
measure: Wall motion abnormality - echo (Presence of wall motion abnormality in at least 1 segment (2D echocardiography)
timeFrame: 1 day
measure: Wall motion index - echo (Wall motion index (2D and 3D echocardiography)
timeFrame: 1 day
measure: Global longitudinal strain (2D and 3D echocardiography)
timeFrame: 1 day
measure: Abnormal cardiogoniometry
timeFrame: 1 day
Other outcomes:
Locations:
city: Greifswald
country: Germany
facility: Marcus Dörr
Study officials:
References:
Clinical trial NCT00878748: Study Evaluating Effexor XR in Chinese Subjects With Major Depressive Disorder
Official title: An Open Label, Prospective and Multi-center Recurrence Prevention Study With Effexor XR in MDD Patients in China
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE4
Conditions: Major Depressive Disorder
Lead sponsor: Wyeth is now a wholly owned subsidiary of Pfizer
Sponsor class: INDUSTRY
First posted: 2009-04-09
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This primary purpose of this study is to assess the efficacy and safety of Effexor XR in preventing recurrence in Chinese patients with recurrent major depressive disorder (MDD) following a 1-year maintenance treatment after an 8-week acute treatment and a 6-month continuation treatment phases. The study will also collect data on the prevalence and pattern of co-morbid anxiety and somatic symptoms and their impact on the recurrence of depression.


Eligibility criteria: Inclusion criteria: 1. Males or females, 18 years of age or more; 2. Outpatients; 3. Major depressive disorder based on DSM-IV criteria, with/without current co-morbid anxiety disorder; 4. Has two or more episodes of depression (including the current episode) in the past 5 years, with an interval of at lease 2 months between the end of the previous episode and the beginning of the current episode. 5. The baseline score of 17-item Hamilton Rating Scale for Depression (HAM-D)\>=17; 6 If female of childbearing potential, have a negative urine pregnancy test at baseline, if appropriate, and use a medically acceptable method of contraception throughout the study.

Exclusion criteria:1.Hypersensitivity to venlafaxine;2.Received venlafaxine treatment before;3.Clinically significant renal or hepatic disease or any other medical disease that, in the opinion of the investigator, might compromise the study, including seizure disorder (with the exception of a single childhood febrile seizure); 4.Alcohol or drug abuse within the last year;5.A recent history of myocardial infarction or unstable heart disease (within 6 months of baseline);6.Bipolar disorder;7.For female, known or suspected pregnancy or breast feeding;8.Use of a monoamine oxidize inhibitor (MAOI) within 14 days of baseline; use of any investigational drug within 30 days of baseline.

Primary outcomes:
measure: time from entering maintenance phase to recurrence of major depression
timeFrame: 12 months
Secondary outcomes:
measure: Patient Health Questionnaire(PHQ-15),Clinical Global Impressions(CGI),Visual Analogue Scale(VAS),Short Form Health Survey(SF-36)
timeFrame: 12 months
Other outcomes:
Locations:
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References:
Clinical trial NCT00139048: Australian Screening Mammography Decision Aid Trial: A Decision Aid for Women Aged 40 Thinking About Starting Mammography Screening
Official title: A Randomised Controlled Trial of an On-line Decision Aid for Women Aged 40 Considering Whether to Have Screening Mammograms to Evaluate the Change in Knowledge Regarding Mammography Screening.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Knowledge of Mammography Screening
Keywords: informed choice
shared decision making
decision aid
mammography screening
decision support
Lead sponsor: University of Sydney
Sponsor class: OTHER
First posted: 2005-08-30
Enrollment: 200
Sex: FEMALE
Minimum age (years): 38
Maximum age (years): 45
Standard ages: ADULT
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Women who access the website, are aged between 38-45 years and are considering screening mammograms will be randomized to either the Decision Aid (a booklet providing information and exercises to help them to make a decision about whether to having screening mammograms) group or the Control Group. The Decision Aid group will first read the decision aid, and then will be asked some demographic and knowledge questions. The control group will be asked the demographic and knowledge questions only. The control group will have access to the Decision Aid after they have completed the questions


Eligibility criteria: Inclusion Criteria:

* female
* aged between 38-45
* have access to the internet

Exclusion Criteria:

-

Primary outcomes:
measure: Assess the change in knowledge about the issues involved in screening mammography in women who have read the decision aid.
Secondary outcomes:
measure: elicit womens views on the decision aid including ease of use, content and presentation of information,
measure: assess the differences in intention to screen
measure: assess the impact of the decision aid on informed choice
Other outcomes:
Locations:
city: Camperdown
country: Australia
facility: University of Sydney
state: New South Wales
Study officials:
affiliation: Screening and Test evaluation programme, School of Public Health, University of Sydney
name: Alex Barratt
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04379648: Assessment of Dissociative Traumatic Disorders
Official title: Assessment of Dissociative Traumatic Disorders
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Posttraumatic Stress Disorder
Lead sponsor: Centre hospitalier de Ville-Evrard, France
Sponsor class: OTHER
First posted: 2020-05-07
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: All patients with a diagnosis of Post Traumatic Stress Disorder will be seen by a physician psychiatrist or psychologist who will introduce them to the study. They will be given an information letter and a consent form. If patients agree to participate in the study, and after signing the consent form, they will be included and will complete the assessment scales.
Primary purpose: OTHER

Brief summary: More than 70% of ambulatory patients with IDD have attempted suicide (APA, 2015). This disorder, as well as all the disorders on the dissociation spectrum, must therefore be clarified and better diagnosed.

The goal of this research is :

1. to assess the prevalence of dissociative disorders using specific tools in patients suffering from PTSD.
2. to validate the French version of the DDIS interview (Ross, 1997) that the investigators have translated.


Eligibility criteria: Inclusion Criteria:

* Patient diagnosed with PTSD according to DSM 5 criteria
* Over 18 years of age
* Informed consent signed

Exclusion Criteria:

* Neurological disorders
* Serious and/or unstable somatic pathologies
* Patient not affiliated with social security
* Patient hospitalized under restraint in psychiatric care by decision of the state representative or in psychiatric care at the request of a third party
* Patient under guardianship
* Patient participating in parallel in another biomedical research
* Change of antidepressant in the last three months
* Patient not mastering the French language

Primary outcomes:
measure: Post Traumatic Stress
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Neuilly Sur Marne
country: France
facility: Youcef BENCHERIF
state: Île De France
Study officials:
affiliation: EPS Ville Evrard
name: Khalid KALALOU, Psychiatrist
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03242148: The Evaluation of the Toffee Nasal Pillows Mask for the Treatment of Obstructive Sleep Apnea
Official title: The Evaluation of the Toffee Nasal Pillows Mask for the Treatment of Obstructive Sleep Apnea
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obstructive Sleep Apnea
Lead sponsor: Fisher and Paykel Healthcare
Sponsor class: INDUSTRY
Collaborators: name: Aspen Clinical Research
First posted: 2017-08-08
Enrollment: 38
Sex: ALL
Minimum age (years): 22
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This investigation is a prospective, non-randomized, non-blinded study. This investigation is designed to evaluate the performance, comfort and ease of use of the F\&P Toffee nasal pillows mask amongst obstructive sleep apnea (OSA) patients. Up to 45 OSA patients will be recruited from the Ohio Sleep Medical Institute (OSMI)

Detailed description: Visit 1 will involve the participants being consented into the trial. Visit 2 will involve the participants being fitted with the F\&P Toffee nasal pillows mask for use in-home.

The participant will then come in to return the mask (Visit Three) and have a final interview, this ensures the maximum time participants will be exposed to the Toffee mask in home will be 14 ± 4 days from visit two.

The mask will be returned to the Institution at the conclusion of the trial and the participant will return to their previous mask. The Institution will recruit all patients within 1 week of the beginning of the study.

Eligibility criteria: Inclusion Criteria:

* Adult (22+ years of age)
* Able to give informed consent
* Apnea hypopnea Index (AHI) ≥ 5 on diagnostic night
* Either prescribed Automatic positive airway pressure (APAP), Continuous positive airway pressure (CPAP) or Bi-level positive airway pressure (PAP) for OSA
* Fluent in spoken and written English
* Existing nasal pillows mask user

Exclusion Criteria:

* Inability to give informed consent
* Participant intolerant to PAP
* Anatomical or physiological conditions making PAP therapy inappropriate
* Current diagnosis of respiratory disease or carbon Dioxide (CO2) retention
* Pregnant or may think they are pregnant.

Primary outcomes:
measure: Toffee Mask Usability
timeFrame: 14 ± 5 days in-Home
measure: Toffee Mask Comfort
timeFrame: 14 ± 5 days in-Home
measure: Toffee Mask Treatment Performance - Subjective
timeFrame: 14 ± 5 days in-Home
measure: Trial Mask Acceptability
timeFrame: 14 ± 5 days in-Home
Secondary outcomes:
measure: Toffee Mask Treatment Performance - Objective
timeFrame: 14 ± 5 days in-Home
Other outcomes:
Locations:
city: Dublin
country: United States
facility: Ohio Sleep Medicine Institute
state: Ohio
Study officials:
affiliation: Board Certified Sleep Specialist
name: Asim Roy
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01344148: Acquired Immunodeficiency Syndrome(AIDS) and Tuberculosis(Tb) Co-infection Treatment Strategies Study of China.
Official title: AIDS and Tuberculosis Co-infection Treatment Strategies Study of China.[ Eleven Fifth Key Research Grant From the Ministry of Science and Technology, the People's Republic of China]
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: AIDS
Keywords: Anti- TB
HAART
choice of the right moment
Lead sponsor: Shanghai Public Health Clinical Center
Sponsor class: OTHER_GOV
First posted: 2011-04-28
Enrollment: 400
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To determine the best time to begin anti-HIV(Acquired Immunodeficiency Syndrome) treatment in individuals who co-infected with HIV and tuberculosis (Tb). This prospective, randomized study is being conducted on HIV/Tb co-infected patients in China to evaluate and compare the efficacy of antiretroviral therapy after 2 weeks TB treatment versus deferred ART initiated 8 weeks after initiation of TB treatment.

Detailed description: Anti-Tb Therapy: 2HREZ-4HRifb(H:Isoniazid，R:Rifampicin，E:Ethambutol，Z：pyrazinamide，Rifb:Rifabutin) HAART: The first line was Zidovudine(AZT)+Lamivudine(3TC)+Efavirenz(EFV) and the second line is Stavudine(D4T)+3TC+EFV Study group one: after anti-TB therapy 2 weeks begin with High Active Antiretroviral Therapy(HAART); study group two: after anti-TB therapy 8 weeks begin with HAART. If begin with HAART and the H change with Rifb.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of AIDS co-infected with TB CD4 T cell count lower than 350/ul Must be able to swallow tablets and finish the follow-up Sign the information consent form Chinese

Exclusion Criteria:

* Can not tolerance the therapy estimated by the doctor.

Primary outcomes:
measure: Number of Participants with Adverse Events as a Measure of Safety and Tolerability
timeFrame: 3 years
Secondary outcomes:
measure: Patients long-term survival.
timeFrame: 5 years
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai Public Health Clinical Center
state: Shanghai
Study officials:
affiliation: Shanghai Public Health Clinical Center Affliated to Fudan University China
name: Lu Hongzhou, MD. PhD
role: STUDY_CHAIR
References:
citation: Ji YJ, Liang PP, Shen JY, Sun JJ, Yang JY, Chen J, Qi TK, Wang ZY, Song W, Tang Y, Liu L, Zhang RF, Shen YZ, Lu HZ. Risk factors affecting the mortality of HIV-infected patients with pulmonary tuberculosis in the cART era: a retrospective cohort study in China. Infect Dis Poverty. 2018 Mar 24;7(1):25. doi: 10.1186/s40249-018-0405-8.
Clinical trial NCT06636448: The Relationship Between Body Mass Index and Patient Outcomes in Low Flow Anaesthesia
Official title: The Effect of Body Mass Index on Patient Outcomes During Low-flow Anaesthesia for Major Gynaecological Cancer Surgery: a Prospective Observational Study
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Major Gynecological Cancer Surgery
Low Flow Anesthesia
Keywords: major gynecological cancer surgery
low flow aneshesia
cerebral oxygenation
hypoxia
Lead sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Sponsor class: OTHER_GOV
First posted: 2024-10-10
Enrollment: 40
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: A total of 40 patients were planned for this study

Brief summary: This study was designed as a prospective observational study.

Detailed description: In this study, it was planned to evaluate the effect of body mass index on patient outcomes during low flow anaesthesia in patients undergoing gynaecological cancer surgery on the specified dates. ASA II and III patients over 18 years of age were included in the study. Low flow anaesthesia is routinely applied in open gynaecological cancer surgeries in our clinic. The relationship between body mass index and intraoperative haemodynamic and mechanical ventilator values and postoperative patient outcomes will be evaluated.

Eligibility criteria: Inclusion Criteria:

* Patients with ASA II-III
* \&gt;18 years
* Patients undergoing major open surgery for endometrium, cervix or ovarian ca in gynaecological oncology clinic

Exclusion Criteria:

* Patients who refused to participate in the study
* Cerebrovascular disease
* Those with severe pulmonary disease
* Those with serious cardiovascular disease

Primary outcomes:
measure: postoperative hospital stay
timeFrame: up to 10 days postoperative
Secondary outcomes:
Other outcomes:
measure: Intraoperative cerebral oxygenation
timeFrame: intraoperative process
Locations:
city: Istanbul
country: Turkey
facility: Duygu
Study officials:
References:
citation: Mychaskiw G 2nd. Low and minimal flow anesthesia: Angels dancing on the point of a needle. J Anaesthesiol Clin Pharmacol. 2012 Oct;28(4):423-5. doi: 10.4103/0970-9185.101883. No abstract available.
citation: Oterkus M, Donmez I, Nadir AH, Rencuzogullari I, Karabag Y, Binnetoglu K. The effect of low flow anesthesia on hemodynamic and peripheral oxygenation parameters in obesity surgery. Saudi Med J. 2021 Mar;42(3):264-269. doi: 10.15537/smj.2021.42.3.20200575.
citation: Akbas S, Ozkan AS. Comparison of effects of low-flow and normal-flow anesthesia on cerebral oxygenation and bispectral index in morbidly obese patients undergoing laparoscopic sleeve gastrectomy: a prospective, randomized clinical trial. Wideochir Inne Tech Maloinwazyjne. 2019 Jan;14(1):19-26. doi: 10.5114/wiitm.2018.77265. Epub 2018 Jul 24.
Clinical trial NCT07019948: The Correlation Between Sleep Quality and Sleep Aid Use and Dietary Patterns
Official title: The Correlation Between Sleep Quality and Sleep Aid Use and Dietary Patterns of Medical Staff in Emergency and Critical Care Departments
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Sleep Disorder (Disorder)
Keywords: sleep quality
Sleep disorders
Sedative-hypnotic drugs
Dietary pattern
Clinical medical staff
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2025-06-13
Enrollment: 378
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Medical staff in emergency and critical care departments of tertiary hospitals in Guangzhou City

Brief summary: In this study, medical staff in emergency and critical care departments were investigated. It was assumed that the use of sleep aids and dietary patterns affected their sleep quality. The structural equation model was used to analyze the status of sleep quality of medical staff in emergency and critical care departments, and to explore the effects of sleep aids and dietary patterns on sleep quality and its mechanism.

( 1 ) Is the overall sleep quality of medical staff in emergency and critical departments poor ( 2 ) Do medical staff with poor sleep quality in acute and critical departments use sleep aids more frequently ( 3 ) Is there a correlation between sleep quality and certain dietary patterns among medical staff in emergency and critical care departments ( 4 ) Are there significant differences in dietary choices among medical staff in emergency and critical departments using sleep aids


Eligibility criteria: Inclusion Criteria:

( 1 ) Medical staff who have obtained the qualification certificate of doctors and nurses through practice registration.

( 2 ) Working in the emergency and critical care departments for more than 1 year ( 3 ) No serious physical disease and psychiatric history. ( 4 ) be able to communicate in Chinese

Exclusion Criteria:

( 1 ) Interns, students or trainees ( 2 ) The last six consecutive months of sick leave, maternity leave, out of the learner ( 3 ) Non-night shift workers

Primary outcomes:
measure: sleep quality
timeFrame: baseline
measure: Sedative-hypnotic drugs
timeFrame: baseline
measure: Food intake
timeFrame: baseline
Secondary outcomes:
measure: perceived stress
timeFrame: baseline
measure: Quality of Life
timeFrame: baseline
Other outcomes:
Locations:
Study officials:
affiliation: Sun Yat-sen University
name: Wei Xia PHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02614248: The Use of Coconut Oil for the Prevention and Treatment of Diaper Dermatitis in the NICU Population
Official title: The Use of Coconut Oil for the Prevention and Treatment of Diaper Dermatitis in the NICU Population
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dermatitis, Contact
Lead sponsor: Genesis Health System
Sponsor class: OTHER
First posted: 2015-11-25
Enrollment: 149
Sex: ALL
Minimum age (years): 5
Maximum age (years): 2
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of the study is to examine the safety and effectiveness of the use of coconut oil for the prevention and treatment of diaper dermatitis among NICU babies at Genesis Medical Center, Davenport.


Eligibility criteria: Inclusion Criteria:

1. Babies admitted to the Genesis NICU
2. Anticipated stay in the NICU is ≥ 48 hours
3. Babies wearing diapers 24 hours a day
4. Parent willing to sign informed consent for the study
5. Parent willing to use the test products in the diaper area during the trial
6. Parent willing to not change the type or brand of diaper and wipes during the study
7. Parent willing to refrain from changing any other products whose use may have an effect of their baby's skin condition during the trial

Exclusion Criteria:

1. Babies with a gestational age \<30 weeks
2. Babies with major congenital malformations
3. Active dermatological conditions other than diaper dermatitis that may affect trial results
4. Known sensitivity to ingredients in trial products
5. Babies whose parents have a hazelnut or coconut allergy
6. Other severe acute medical conditions that may increase the risk associated with trial participation

Primary outcomes:
measure: The Number of Days Free From Diaper Dermatitis
timeFrame: Once, at hospital discharge, an average of 2 weeks
measure: The Number of Patients Experiencing Adverse Events
timeFrame: Once, at hospital discharge, an average of 2 weeks
Secondary outcomes:
measure: The Percent of Parents Stating Satisfaction With the Diaper Dermatitis Treatment Used
timeFrame: Once, at study completion for hospital discharge, an average of 2 weeks
Other outcomes:
Locations:
city: Davenport
country: United States
facility: Genesis Medical Center, East Campus
state: Iowa
Study officials:
References: