Clinical trial NCT05376657: Evaluation of Antioxidant and Skin Beauty Effects of Cherry Collagen Drink
Official title: Evaluation of Antioxidant and Skin Beauty Effects of Cherry Collagen Drink
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Skin Condition
Lead sponsor: TCI Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2022-05-17
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: To assess cherry collagen drink on skin condition improvement


Eligibility criteria: Inclusion Criteria:

* Healthy adults aged above 20 years old

Exclusion Criteria:

* Subject who is not willing to participate in this study.
* Patients with diseases of the skin, liver, kidney.
* Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
* Female who is pregnant or nursing or planning to become pregnant during the course of the study.
* Received facial laser therapy, chemical peeling or UV overexposure (\> 3 hr/week) in the past 4 weeks.
* Constant drug use
* Students who are currently taking courses taught by the principal investigator of this trial.
* Body weight \< 50 kg.

Primary outcomes:
measure: The change of skin wrinkles
timeFrame: Change from Baseline skin wrinkles at 8 weeks
measure: The change of skin texture
timeFrame: Change from Baseline skin texture at 8 weeks
measure: The change of skin collagen density
timeFrame: Change from Baseline skin collagen density at 8 weeks
measure: The change of skin elasticity
timeFrame: Change from Baseline skin elasticity at 8 weeks
Secondary outcomes:
measure: The change of skin melanin index
timeFrame: Change from Baseline skin melanin index at 8 weeks
measure: The change of skin L* value
timeFrame: Change from Baseline L* value at 8 weeks
measure: The change of skin moisture
timeFrame: Change from Baseline skin moisture at 8 weeks
measure: The change of skin spots
timeFrame: Change from Baseline skin spots at 8 weeks
measure: The change of skin UV spots
timeFrame: Change from Baseline skin UV spots at 8 weeks
measure: The change of skin brown spots
timeFrame: Change from Baseline skin brown spots at 8 weeks
measure: The change of SOD-RBC of blood
timeFrame: Change from Baseline SOD-RBC at 8 weeks
measure: The change of t-GSH of blood
timeFrame: Change from Baseline t-GSH at 8 weeks
measure: The change of GST-RBC of blood
timeFrame: Change from Baseline GST-RBC at 8 weeks
measure: The change of blood total antioxidant capacity (TAC)
timeFrame: Change from Baseline TAC at 8 weeks
measure: The change of desmosine of blood
timeFrame: Change from Baseline desmosine at 8 weeks
measure: The change of TNF-alpha of blood
timeFrame: Change from Baseline TNF-alpha at 8 weeks
measure: The change of transepidermal water loss (TEWL)
timeFrame: Change from Baseline TEWL at 8 weeks
Other outcomes:
measure: The change of liver function biomarkers (AST, ALT) of blood
timeFrame: Change from Baseline liver function biomarkers at 8 weeks
measure: The change of renal function biomarkers (creatinine, BUN) of blood
timeFrame: Change from Baseline renal function biomarkers at 8 weeks
measure: The change of self-assessment skin condition
timeFrame: Change from Baseline skin condition at 8 weeks
Locations:
city: Tainan City
country: Taiwan
facility: Chia Nan University of Pharmacy & Science
Study officials:
affiliation: Chia Nan University of Pharmacy ＆ Science
name: Chia-Hua Liang
role: PRINCIPAL_INVESTIGATOR
References: