Clinical trial NCT01225562: Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin
Official title: A Randomized, Double-Blind, Placebo Controlled, Parallel Group, Multinational Trial, to Assess the Prevention of Thrombotic Events With Ticagrelor Compared to Placebo on a Background of Acetyl Salicylic Acid (ASA) Therapy in Patients With History of Myocardial Infarction
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Myocardial Infarction
Cardiovascular Death
Atherothrombosis
Stroke
Keywords: Heart attack
Heart Disease
Acute coronary syndrome
ACS
Cardiovascular Disease
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2010-10-21
Enrollment: 21379
Sex: ALL
Minimum age (years): 50
Maximum age (years): 130
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study is being carried out to see if a new drug called ticagrelor given twice daily in addition to the ASA therapy decreases the frequency of cardiovascular events (e.g., death from heart disease, heart attack, or stroke).


Eligibility criteria: Inclusion Criteria:

* Person who had a heart attack within 1 - 3 years ago and at least one additional risk factor: Age ≥ 65 years old, Diabetes requiring medication, Documented history of 2nd prior MI (\>1 year ago). Angiographic evidence of multivessel CAD, and / or Chronic, non-end stage renal dysfunction.
* Females of child-bearing potential must have a negative pregnancy test at enrollment
* Persons who are currently taking aspirin between 75 and 150 mg once daily

Exclusion Criteria:

* Persons who are being treated with agents inhibiting blood clotting if the agent cannot be stopped at study start
* Persons who have planned coronary, cerebrovascular, or peripheral arterial Revascularization (invasive surgery) at study start
* Persons with known bleeding disorders
* Persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin
* Persons with a history of ischemic stroke
* Persons with a history of intracranial bleeding at any time, a tumor or blood vessel abnormality in the brain and/or spinal cord at any time, a history of surgery involving the brain or spinal cord within the last 5 years, or a history of bleeding from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the last 6 months or a major surgery within the last 30 days.
* Persons considered to be at risk of bradycardic events unless already treated with a permanent pacemaker
* Persons who have had open heart surgery within the past 5 years, unless the person had a heart attack after the surgery
* Persons with known severe liver disease
* Persons with kidney failure requiring dialysis
* Persons with life expectancy \< 1 year

Primary outcomes:
measure: Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death), Myocardial Infarction (MI) or Stroke Within 3 Years From Randomization
timeFrame: Randomization up to 47 months
measure: Kaplan-Meier Estimate of the Percentage of Patients Who Experienced a TIMI Major Bleeding Within 3 Years From First Dose of Study Drug Units: Percentage of Patients
timeFrame: First dosing up to 48 months
Secondary outcomes:
measure: Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death) Within 3 Years From Randomization
timeFrame: Randomization up to 47 months
measure: Kaplan-Meier Estimate of the Percentage of Patients Who Died From Any Cause Within 3 Years From Randomization
timeFrame: Randomization up to 47 months
Other outcomes:
Locations:
city: Alexander City
country: United States
facility: Research Site
state: Alabama
city: Athens
country: United States
facility: Research Site
state: Alabama
city: Birmingham
country: United States
facility: Research Site
state: Alabama
city: Huntsville
country: United States
facility: Research Site
state: Alabama
city: Mobile
country: United States
facility: Research Site
state: Alabama
city: Sheffield
country: United States
facility: Research Site
state: Alabama
city: Glendale
country: United States
facility: Research Site
state: Arizona
city: Phoenix
country: United States
facility: Research Site
state: Arizona
city: Jonesboro
country: United States
facility: Research Site
state: Arkansas
city: Little Rock
country: United States
facility: Research Site
state: Arkansas
city: Alhambra
country: United States
facility: Research Site
state: California
city: Anaheim
country: United States
facility: Research Site
state: California
city: Bakersfield
country: United States
facility: Research Site
state: California
city: Fountain Valley
country: United States
facility: Research Site
state: California
city: La Mesa
country: United States
facility: Research Site
state: California
city: Larkspur
country: United States
facility: Research Site
state: California
city: Lomita
country: United States
facility: Research Site
state: California
city: Los Angeles
country: United States
facility: Research Site
state: California
city: Modesto
country: United States
facility: Research Site
state: California
city: Newport Beach
country: United States
facility: Research Site
state: California
city: Oakland
country: United States
facility: Research Site
state: California
city: Oceanside
country: United States
facility: Research Site
state: California
city: San Diego
country: United States
facility: Research Site
state: California
city: San Marino
country: United States
facility: Research Site
state: California
city: Santa Rosa
country: United States
facility: Research Site
state: California
city: Ventura
country: United States
facility: Research Site
state: California
city: Westlake Village
country: United States
facility: Research Site
state: California
city: Aurora
country: United States
facility: Research Site
state: Colorado
city: Colorado Springs
country: United States
facility: Research Site
state: Colorado
city: Littleton
country: United States
facility: Research Site
state: Colorado
city: Loveland
country: United States
facility: Research Site
state: Colorado
city: Hartford
country: United States
facility: Research Site
state: Connecticut
city: Stamford
country: United States
facility: Research Site
state: Connecticut
city: Newark
country: United States
facility: Research Site
state: Delaware
city: Washington
country: United States
facility: Research Site
state: District of Columbia
city: Boca Raton
country: United States
facility: Research Site
state: Florida
city: Clearwater
country: United States
facility: Research Site
state: Florida
city: Coral Springs
country: United States
facility: Research Site
state: Florida
city: Crystal River
country: United States
facility: Research Site
state: Florida
city: Davie
country: United States
facility: Research Site
state: Florida
city: Daytona Beach
country: United States
facility: Research Site
state: Florida
city: Daytona
country: United States
facility: Research Site
state: Florida
city: Ft Lauderdale
country: United States
facility: Research Site
state: Florida
city: Gainesville
country: United States
facility: Research Site
state: Florida
city: Hialeah
country: United States
facility: Research Site
state: Florida
city: Hollywood
country: United States
facility: Research Site
state: Florida
city: Jacksonville
country: United States
facility: Research Site
state: Florida
city: Jupiter
country: United States
facility: Research Site
state: Florida
city: Largo
country: United States
facility: Research Site
state: Florida
city: Leesburg
country: United States
facility: Research Site
state: Florida
city: Miami Beach
country: United States
facility: Research Site
state: Florida
city: Miami
country: United States
facility: Research Site
state: Florida
city: Naples
country: United States
facility: Research Site
state: Florida
city: Ocala
country: United States
facility: Research Site
state: Florida
city: Orlando
country: United States
facility: Research Site
state: Florida
city: Pannama City
country: United States
facility: Research Site
state: Florida
city: Pensacola
country: United States
facility: Research Site
state: Florida
city: Port Charlotte
country: United States
facility: Research Site
state: Florida
city: Safety Harbor
country: United States
facility: Research Site
state: Florida
city: Sarasota
country: United States
facility: Research Site
state: Florida
city: South Miami
country: United States
facility: Research Site
state: Florida
city: St Petersburg
country: United States
facility: Research Site
state: Florida
city: Tallahassee
country: United States
facility: Research Site
state: Florida
city: The Villages
country: United States
facility: Research Site
state: Florida
city: Wellington
country: United States
facility: Research Site
state: Florida
city: West Palm Beach
country: United States
facility: Research Site
state: Florida
city: Atlanta
country: United States
facility: Research Site
state: Georgia
city: Augusta
country: United States
facility: Research Site
state: Georgia
city: Cumming
country: United States
facility: Research Site
state: Georgia
city: Honolulu
country: United States
facility: Research Site
state: Hawaii
city: Boise
country: United States
facility: Research Site
state: Idaho
city: Aurora
country: United States
facility: Research Site
state: Illinois
city: Bannockburn
country: United States
facility: Research Site
state: Illinois
city: Chicago
country: United States
facility: Research Site
state: Illinois
city: Melrose Park
country: United States
facility: Research Site
state: Illinois
city: Normal
country: United States
facility: Research Site
state: Illinois
city: Rock Island
country: United States
facility: Research Site
state: Illinois
city: Avon
country: United States
facility: Research Site
state: Indiana
city: Elkhart
country: United States
facility: Research Site
state: Indiana
city: Fort Wayne
country: United States
facility: Research Site
state: Indiana
city: Franklin
country: United States
facility: Research Site
state: Indiana
city: Indianapolis
country: United States
facility: Research Site
state: Indiana
city: Muncie
country: United States
facility: Research Site
state: Indiana
city: Munster
country: United States
facility: Research Site
state: Indiana
city: Iowa City
country: United States
facility: Research Site
state: Iowa
city: Hutchinson
country: United States
facility: Research Site
state: Kansas
city: Crestview Hills
country: United States
facility: Research Site
state: Kentucky
city: Lexington
country: United States
facility: Research Site
state: Kentucky
city: Louisville
country: United States
facility: Research Site
state: Kentucky
city: Alexandria
country: United States
facility: Research Site
state: Louisiana
city: Covington
country: United States
facility: Research Site
state: Louisiana
city: Minden
country: United States
facility: Research Site
state: Louisiana
city: New Iberia
country: United States
facility: Research Site
state: Louisiana
city: Opelousas
country: United States
facility: Research Site
state: Louisiana
city: Shreveport
country: United States
facility: Research Site
state: Louisiana
city: Slidell
country: United States
facility: Research Site
state: Louisiana
city: Auburn
country: United States
facility: Research Site
state: Maine
city: Bangor
country: United States
facility: Research Site
state: Maine
city: Biddeford
country: United States
facility: Research Site
state: Maine
city: S Portland
country: United States
facility: Research Site
state: Maine
city: Baltimore
country: United States
facility: Research Site
state: Maryland
city: Columbia
country: United States
facility: Research Site
state: Maryland
city: Oxon Hill
country: United States
facility: Research Site
state: Maryland
city: Salisbury
country: United States
facility: Research Site
state: Maryland
city: Ayer
country: United States
facility: Research Site
state: Massachusetts
city: Boston
country: United States
facility: Research Site
state: Massachusetts
city: Burlington
country: United States
facility: Research Site
state: Massachusetts
city: Haverhill
country: United States
facility: Research Site
state: Massachusetts
city: North Dartmouth
country: United States
facility: Research Site
state: Massachusetts
city: Alpena
country: United States
facility: Research Site
state: Michigan
city: Ann Arbor
country: United States
facility: Research Site
state: Michigan
city: Detroit
country: United States
facility: Research Site
state: Michigan
city: Flint
country: United States
facility: Research Site
state: Michigan
city: Grand Blanc
country: United States
facility: Research Site
state: Michigan
city: Grand Rapids
country: United States
facility: Research Site
state: Michigan
city: Jackson
country: United States
facility: Research Site
state: Michigan
city: Lapeer
country: United States
facility: Research Site
state: Michigan
city: Marquette
country: United States
facility: Research Site
state: Michigan
city: Petoskey
country: United States
facility: Research Site
state: Michigan
city: Pontiac
country: United States
facility: Research Site
state: Michigan
city: Saginaw
country: United States
facility: Research Site
state: Michigan
city: Southfield
country: United States
facility: Research Site
state: Michigan
city: Ypsilanti
country: United States
facility: Research Site
state: Michigan
city: Baxter
country: United States
facility: Research Site
state: Minnesota
city: Duluth
country: United States
facility: Research Site
state: Minnesota
city: Minneapolis
country: United States
facility: Research Site
state: Minnesota
city: Robbinsdale
country: United States
facility: Research Site
state: Minnesota
city: St Cloud
country: United States
facility: Research Site
state: Minnesota
city: Biloxi
country: United States
facility: Research Site
state: Mississippi
city: Tupelo
country: United States
facility: Research Site
state: Mississippi
city: Columbia
country: United States
facility: Research Site
state: Missouri
city: Kansas City
country: United States
facility: Research Site
state: Missouri
city: St Louis
country: United States
facility: Research Site
state: Missouri
city: Billings
country: United States
facility: Research Site
state: Montana
city: Great Falls
country: United States
facility: Research Site
state: Montana
city: Kalispell
country: United States
facility: Research Site
state: Montana
city: Lincoln
country: United States
facility: Research Site
state: Nebraska
city: Omaha
country: United States
facility: Research Site
state: Nebraska
city: Papillion
country: United States
facility: Research Site
state: Nebraska
city: Reno
country: United States
facility: Research Site
state: Nevada
city: Bridgewater
country: United States
facility: Research Site
state: New Jersey
city: Elizabeth
country: United States
facility: Research Site
state: New Jersey
city: Elmer
country: United States
facility: Research Site
state: New Jersey
city: Haddon Heights
country: United States
facility: Research Site
state: New Jersey
city: Linden
country: United States
facility: Research Site
state: New Jersey
city: Mine Hill
country: United States
facility: Research Site
state: New Jersey
city: Newark
country: United States
facility: Research Site
state: New Jersey
city: Ridgewood
country: United States
facility: Research Site
state: New Jersey
city: Somerset
country: United States
facility: Research Site
state: New Jersey
city: Albuquerque
country: United States
facility: Research Site
state: New Mexico
city: Bronx
country: United States
facility: Research Site
state: New York
city: Buffalo
country: United States
facility: Research Site
state: New York
city: Cortlandt Manor
country: United States
facility: Research Site
state: New York
city: Mineola
country: United States
facility: Research Site
state: New York
city: New Windsor
country: United States
facility: Research Site
state: New York
city: Poughkeepsie
country: United States
facility: Research Site
state: New York
city: Saratoga Springs
country: United States
facility: Research Site
state: New York
city: Southampton
country: United States
facility: Research Site
state: New York
city: Stony Brook
country: United States
facility: Research Site
state: New York
city: Williamsville
country: United States
facility: Research Site
state: New York
city: Asheville
country: United States
facility: Research Site
state: North Carolina
city: Burlington
country: United States
facility: Research Site
state: North Carolina
city: Cary
country: United States
facility: Research Site
state: North Carolina
city: Greensboro
country: United States
facility: Research Site
state: North Carolina
city: Hickory
country: United States
facility: Research Site
state: North Carolina
city: Morganton
country: United States
facility: Research Site
state: North Carolina
city: Pinehurst
country: United States
facility: Research Site
state: North Carolina
city: Raleigh
country: United States
facility: Research Site
state: North Carolina
city: Rocky Mount
country: United States
facility: Research Site
state: North Carolina
city: Sanford
country: United States
facility: Research Site
state: North Carolina
city: Smithfield
country: United States
facility: Research Site
state: North Carolina
city: Statesville
country: United States
facility: Research Site
state: North Carolina
city: Wilmington
country: United States
facility: Research Site
state: North Carolina
city: Grand Forks
country: United States
facility: Research Site
state: North Dakota
city: Akron
country: United States
facility: Research Site
state: Ohio
city: Canton
country: United States
facility: Research Site
state: Ohio
city: Cincinnati
country: United States
facility: Research Site
state: Ohio
city: Cleveland
country: United States
facility: Research Site
state: Ohio
city: Columbus
country: United States
facility: Research Site
state: Ohio
city: Dayton
country: United States
facility: Research Site
state: Ohio
city: Fairfield
country: United States
facility: Research Site
state: Ohio
city: Mansfield
country: United States
facility: Research Site
state: Ohio
city: Sandusky
country: United States
facility: Research Site
state: Ohio
city: Springfield
country: United States
facility: Research Site
state: Ohio
city: Toledo
country: United States
facility: Research Site
state: Ohio
city: Youngstown
country: United States
facility: Research Site
state: Ohio
city: Zanesville
country: United States
facility: Research Site
state: Ohio
city: Oklahoma City
country: United States
facility: Research Site
state: Oklahoma
city: Tulsa
country: United States
facility: Research Site
state: Oklahoma
city: Bend
country: United States
facility: Research Site
state: Oregon
city: Portland
country: United States
facility: Research Site
state: Oregon
city: Altoona
country: United States
facility: Research Site
state: Pennsylvania
city: Beaver
country: United States
facility: Research Site
state: Pennsylvania
city: Bethlehem
country: United States
facility: Research Site
state: Pennsylvania
city: Chambersburg
country: United States
facility: Research Site
state: Pennsylvania
city: Doylestown
country: United States
facility: Research Site
state: Pennsylvania
city: Erie
country: United States
facility: Research Site
state: Pennsylvania
city: Johnstown
country: United States
facility: Research Site
state: Pennsylvania
city: Lancaster
country: United States
facility: Research Site
state: Pennsylvania
city: Langhorne
country: United States
facility: Research Site
state: Pennsylvania
city: Philadelphia
country: United States
facility: Research Site
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Research Site
state: Pennsylvania
city: Scranton
country: United States
facility: Research Site
state: Pennsylvania
city: Sellersville
country: United States
facility: Research Site
state: Pennsylvania
city: West Chester
country: United States
facility: Research Site
state: Pennsylvania
city: York
country: United States
facility: Research Site
state: Pennsylvania
city: Providence
country: United States
facility: Research Site
state: Rhode Island
city: Anderson
country: United States
facility: Research Site
state: South Carolina
city: Charleston
country: United States
facility: Research Site
state: South Carolina
city: Florence
country: United States
facility: Research Site
state: South Carolina
city: Greenville
country: United States
facility: Research Site
state: South Carolina
city: Rapid City
country: United States
facility: Research Site
state: South Dakota
city: Watertown
country: United States
facility: Research Site
state: South Dakota
city: Germantown
country: United States
facility: Research Site
state: Tennessee
city: Jackson
country: United States
facility: Research Site
state: Tennessee
city: Knoxville
country: United States
facility: Research Site
state: Tennessee
city: Nashville
country: United States
facility: Research Site
state: Tennessee
city: Oak Ridge
country: United States
facility: Research Site
state: Tennessee
city: Tullahoma
country: United States
facility: Research Site
state: Tennessee
city: Austin
country: United States
facility: Research Site
state: Texas
city: Dallas
country: United States
facility: Research Site
state: Texas
city: Fort Worth
country: United States
facility: Research Site
state: Texas
city: Georgetown
country: United States
facility: Research Site
state: Texas
city: Grapevine
country: United States
facility: Research Site
state: Texas
city: Houston
country: United States
facility: Research Site
state: Texas
city: Katy
country: United States
facility: Research Site
state: Texas
city: Kingwood
country: United States
facility: Research Site
state: Texas
city: MC Allen
country: United States
facility: Research Site
state: Texas
city: McAllen
country: United States
facility: Research Site
state: Texas
city: Plano
country: United States
facility: Research Site
state: Texas
city: Round Rock
country: United States
facility: Research Site
state: Texas
city: San Antonio
country: United States
facility: Research Site
state: Texas
city: Tomball
country: United States
facility: Research Site
state: Texas
city: Tyler
country: United States
facility: Research Site
state: Texas
city: Victoria
country: United States
facility: Research Site
state: Texas
city: Provo
country: United States
facility: Research Site
state: Utah
city: Burlington
country: United States
facility: Research Site
state: Vermont
city: Alexandria
country: United States
facility: Research Site
state: Virginia
city: Charlottesville
country: United States
facility: Research Site
state: Virginia
city: Danville
country: United States
facility: Research Site
state: Virginia
city: Falls Church
country: United States
facility: Research Site
state: Virginia
city: Lynchburg
country: United States
facility: Research Site
state: Virginia
city: Manassas
country: United States
facility: Research Site
state: Virginia
city: Norfolk
country: United States
facility: Research Site
state: Virginia
city: Richmond
country: United States
facility: Research Site
state: Virginia
city: Winchester
country: United States
facility: Research Site
state: Virginia
city: Bellevue
country: United States
facility: Research Site
state: Washington
city: Everett
country: United States
facility: Research Site
state: Washington
city: Spokane
country: United States
facility: Research Site
state: Washington
city: Tacoma
country: United States
facility: Research Site
state: Washington
city: Green Bay
country: United States
facility: Research Site
state: Wisconsin
city: Wausau
country: United States
facility: Research Site
state: Wisconsin
city: Bahia Blanca
country: Argentina
facility: Research Site
city: Buenos Aires
country: Argentina
facility: Research Site
city: Ciudad Autonoma de BA
country: Argentina
facility: Research Site
city: Ciudad de Buenos Aires
country: Argentina
facility: Research Site
city: Ciudadela
country: Argentina
facility: Research Site
city: Cordoba
country: Argentina
facility: Research Site
city: Coronel Suarez
country: Argentina
facility: Research Site
city: Corrientes
country: Argentina
facility: Research Site
city: Córdoba
country: Argentina
facility: Research Site
city: Haedo
country: Argentina
facility: Research Site
city: La Plata
country: Argentina
facility: Research Site
city: Mar del Plata
country: Argentina
facility: Research Site
city: Ramos Mejía
country: Argentina
facility: Research Site
city: Rosario Santa Fe
country: Argentina
facility: Research Site
city: Rosario
country: Argentina
facility: Research Site
city: San Luis
country: Argentina
facility: Research Site
city: San Miguel de Tucuman
country: Argentina
facility: Research Site
city: San Nicolas
country: Argentina
facility: Research Site
city: San Salvador de Jujuy
country: Argentina
facility: Research Site
city: Santa Fe
country: Argentina
facility: Research Site
city: Santa Fé
country: Argentina
facility: Research Site
city: Tucuman
country: Argentina
facility: Research Site
city: Tucumán
country: Argentina
facility: Research Site
city: Zarate
country: Argentina
facility: Research Site
city: Adelaide
country: Australia
facility: Research Site
city: Ashford
country: Australia
facility: Research Site
city: Auchenflower
country: Australia
facility: Research Site
city: Ballarat
country: Australia
facility: Research Site
city: Bruce
country: Australia
facility: Research Site
city: Chermside
country: Australia
facility: Research Site
city: Clayton
country: Australia
facility: Research Site
city: Concord
country: Australia
facility: Research Site
city: East St Kilda
country: Australia
facility: Research Site
city: Elizabeth Vale
country: Australia
facility: Research Site
city: Epping
country: Australia
facility: Research Site
city: Fremantle
country: Australia
facility: Research Site
city: Geelong
country: Australia
facility: Research Site
city: Gosford
country: Australia
facility: Research Site
city: Greenslopes
country: Australia
facility: Research Site
city: Herston
country: Australia
facility: Research Site
city: Joondalup
country: Australia
facility: Research Site
city: Kingswood
country: Australia
facility: Research Site
city: Kogorah
country: Australia
facility: Research Site
city: Launceston
country: Australia
facility: Research Site
city: Melbourne
country: Australia
facility: Research Site
city: Nedlands
country: Australia
facility: Research Site
city: New Lambton Heights
country: Australia
facility: Research Site
city: Richmond
country: Australia
facility: Research Site
city: St Leonards
country: Australia
facility: Research Site
city: Wollongong
country: Australia
facility: Research Site
city: Woodville
country: Australia
facility: Research Site
city: Woolloongabba
country: Australia
facility: Research Site
city: Aalst
country: Belgium
facility: Research Site
city: Antwerpen
country: Belgium
facility: Research Site
city: Bonheiden
country: Belgium
facility: Research Site
city: Bouge
country: Belgium
facility: Research Site
city: Brasschaat
country: Belgium
facility: Research Site
city: Brussels (Anderlecht)
country: Belgium
facility: Research Site
city: Brussels (Jette)
country: Belgium
facility: Research Site
city: Brussels (Woluwé-St-Lambert)
country: Belgium
facility: Research Site
city: Brussels
country: Belgium
facility: Research Site
city: Charleroi
country: Belgium
facility: Research Site
city: Edegem
country: Belgium
facility: Research Site
city: Genk
country: Belgium
facility: Research Site
city: Gent
country: Belgium
facility: Research Site
city: Hasselt
country: Belgium
facility: Research Site
city: Huy
country: Belgium
facility: Research Site
city: La Louvière
country: Belgium
facility: Research Site
city: Leuven
country: Belgium
facility: Research Site
city: Liege
country: Belgium
facility: Research Site
city: Liège
country: Belgium
facility: Research Site
city: Mechelen
country: Belgium
facility: Research Site
city: Mol
country: Belgium
facility: Research Site
city: Ottignies
country: Belgium
facility: Research Site
city: Roeselare
country: Belgium
facility: Research Site
city: Tienen
country: Belgium
facility: Research Site
city: Turnhout
country: Belgium
facility: Research Site
city: Yvoir
country: Belgium
facility: Research Site
city: Zottegem
country: Belgium
facility: Research Site
city: Aracaju
country: Brazil
facility: Research Site
city: Belo Horizonte
country: Brazil
facility: Research Site
city: Blumenau
country: Brazil
facility: Research Site
city: Brasília
country: Brazil
facility: Research Site
city: Campina Grande do Sul
country: Brazil
facility: Research Site
city: Campinas
country: Brazil
facility: Research Site
city: Campo Grande
country: Brazil
facility: Research Site
city: Curitiba
country: Brazil
facility: Research Site
city: Goiânia
country: Brazil
facility: Research Site
city: Maceio
country: Brazil
facility: Research Site
city: Marilia
country: Brazil
facility: Research Site
city: Porto Alegre
country: Brazil
facility: Research Site
city: Ribeirão Preto
country: Brazil
facility: Research Site
city: Rio de Janeiro
country: Brazil
facility: Research Site
city: S.J.Rio Preto
country: Brazil
facility: Research Site
city: Salvador
country: Brazil
facility: Research Site
city: São José do Rio Preto
country: Brazil
facility: Research Site
city: São Paulo
country: Brazil
facility: Research Site
city: Uberlândia
country: Brazil
facility: Research Site
city: Votuporanga
country: Brazil
facility: Research Site
city: Dimitrovgrad
country: Bulgaria
facility: Research Site
city: Gotse Delchev
country: Bulgaria
facility: Research Site
city: Pernik
country: Bulgaria
facility: Research Site
city: Pleven
country: Bulgaria
facility: Research Site
city: Plovdiv
country: Bulgaria
facility: Research Site
city: Razlog
country: Bulgaria
facility: Research Site
city: Ruse
country: Bulgaria
facility: Research Site
city: Sevlievo
country: Bulgaria
facility: Research Site
city: Sofia
country: Bulgaria
facility: Research Site
city: Varna
country: Bulgaria
facility: Research Site
city: Veliko Tarnovo
country: Bulgaria
facility: Research Site
city: Edmonton
country: Canada
facility: Research Site
state: Alberta
city: Kelowna
country: Canada
facility: Research Site
state: British Columbia
city: New Westminster
country: Canada
facility: Research Site
state: British Columbia
city: Penticton
country: Canada
facility: Research Site
state: British Columbia
city: Surrey
country: Canada
facility: Research Site
state: British Columbia
city: Vancouver
country: Canada
facility: Research Site
state: British Columbia
city: Victoria
country: Canada
facility: Research Site
state: British Columbia
city: Moncton
country: Canada
facility: Research Site
state: New Brunswick
city: Saint John
country: Canada
facility: Research Site
state: New Brunswick
city: St. John's
country: Canada
facility: Research Site
state: Newfoundland and Labrador
city: Halifax
country: Canada
facility: Research Site
state: Nova Scotia
city: Brampton
country: Canada
facility: Research Site
state: Ontario
city: Burlington
country: Canada
facility: Research Site
state: Ontario
city: Cambridge
country: Canada
facility: Research Site
state: Ontario
city: Cornwall
country: Canada
facility: Research Site
state: Ontario
city: Hamilton
country: Canada
facility: Research Site
state: Ontario
city: Kitchener
country: Canada
facility: Research Site
state: Ontario
city: London
country: Canada
facility: Research Site
state: Ontario
city: Mississauga
country: Canada
facility: Research Site
state: Ontario
city: Newmarket
country: Canada
facility: Research Site
state: Ontario
city: North York
country: Canada
facility: Research Site
state: Ontario
city: Oshawa
country: Canada
facility: Research Site
state: Ontario
city: Ottawa
country: Canada
facility: Research Site
state: Ontario
city: Sarnia
country: Canada
facility: Research Site
state: Ontario
city: Scarborough
country: Canada
facility: Research Site
state: Ontario
city: Sudbury
country: Canada
facility: Research Site
state: Ontario
city: Thunder Bay
country: Canada
facility: Research Site
state: Ontario
city: Toronto
country: Canada
facility: Research Site
state: Ontario
city: Windsor
country: Canada
facility: Research Site
state: Ontario
city: Chicoutimi
country: Canada
facility: Research Site
state: Quebec
city: Gatineau
country: Canada
facility: Research Site
state: Quebec
city: Greenfield Park
country: Canada
facility: Research Site
state: Quebec
city: Laval
country: Canada
facility: Research Site
state: Quebec
city: Levis
country: Canada
facility: Research Site
state: Quebec
city: Longueuil
country: Canada
facility: Research Site
state: Quebec
city: Montreal
country: Canada
facility: Research Site
state: Quebec
city: Montréal
country: Canada
facility: Research Site
state: Quebec
city: Saint-Charles-Borromee
country: Canada
facility: Research Site
state: Quebec
city: Saint-Georges
country: Canada
facility: Research Site
state: Quebec
city: Saint-Jerome
country: Canada
facility: Research Site
state: Quebec
city: St-Lambert
country: Canada
facility: Research Site
state: Quebec
city: Terrebonne
country: Canada
facility: Research Site
state: Quebec
city: Thetford Mines
country: Canada
facility: Research Site
state: Quebec
city: Val d'Or
country: Canada
facility: Research Site
state: Quebec
city: Saskatoon
country: Canada
facility: Research Site
state: Saskatchewan
city: Quebec
country: Canada
facility: Research Site
city: Concepcion
country: Chile
facility: Research Site
city: Osorno
country: Chile
facility: Research Site
city: Rancagua
country: Chile
facility: Research Site
city: Santiago Centro
country: Chile
facility: Research Site
city: Santiago
country: Chile
facility: Research Site
city: Temuco
country: Chile
facility: Research Site
city: Vina del Mar
country: Chile
facility: Research Site
city: Beijing
country: China
facility: Research Site
city: Changsha
country: China
facility: Research Site
city: Chongqing
country: China
facility: Research Site
city: Guang Zhou
country: China
facility: Research Site
city: Guangzhou
country: China
facility: Research Site
city: Hang Zhou
country: China
facility: Research Site
city: Lanzhou
country: China
facility: Research Site
city: Nanjing
country: China
facility: Research Site
city: Shanghai
country: China
facility: Research Site
city: Shengyang
country: China
facility: Research Site
city: Shenyang
country: China
facility: Research Site
city: Taiyuan
country: China
facility: Research Site
city: Wuhan
country: China
facility: Research Site
city: Xi'an
country: China
facility: Research Site
city: Armenia
country: Colombia
facility: Research Site
city: Barranquilla
country: Colombia
facility: Research Site
city: Bogota
country: Colombia
facility: Research Site
city: Bogotá D.C.
country: Colombia
facility: Research Site
city: Bucaramanga
country: Colombia
facility: Research Site
city: Cali
country: Colombia
facility: Research Site
city: Cartagena
country: Colombia
facility: Research Site
city: Manizales
country: Colombia
facility: Research Site
city: Medellin
country: Colombia
facility: Research Site
city: Medellín
country: Colombia
facility: Research Site
city: Medillin
country: Colombia
facility: Research Site
city: Brno
country: Czech Republic
facility: Research Site
city: Caslav
country: Czech Republic
facility: Research Site
city: Ceska Lipa
country: Czech Republic
facility: Research Site
city: Cesky Krumlov
country: Czech Republic
facility: Research Site
city: Chomutov
country: Czech Republic
facility: Research Site
city: Havirov
country: Czech Republic
facility: Research Site
city: Kromeriz
country: Czech Republic
facility: Research Site
city: Kyjov
country: Czech Republic
facility: Research Site
city: Liberec
country: Czech Republic
facility: Research Site
city: Marianske Lazne
country: Czech Republic
facility: Research Site
city: Ostrava-Poruba
country: Czech Republic
facility: Research Site
city: Ostrava-Zabreh
country: Czech Republic
facility: Research Site
city: Ostrava
country: Czech Republic
facility: Research Site
city: Pelhrimov
country: Czech Republic
facility: Research Site
city: Praha 2
country: Czech Republic
facility: Research Site
city: Praha 5
country: Czech Republic
facility: Research Site
city: Praha 6
country: Czech Republic
facility: Research Site
city: Pribram
country: Czech Republic
facility: Research Site
city: Slany
country: Czech Republic
facility: Research Site
city: Teplice
country: Czech Republic
facility: Research Site
city: Usti nad Labem
country: Czech Republic
facility: Research Site
city: Usti nad Orlici
country: Czech Republic
facility: Research Site
city: Znojmo
country: Czech Republic
facility: Research Site
city: ABBEVILLE cedex
country: France
facility: Research Site
city: Albi
country: France
facility: Research Site
city: ANGERS Cedex 9
country: France
facility: Research Site
city: Angers
country: France
facility: Research Site
city: Avignon Cedex
country: France
facility: Research Site
city: Bayonne
country: France
facility: Research Site
city: Cannes
country: France
facility: Research Site
city: Creteil
country: France
facility: Research Site
city: Dijon
country: France
facility: Research Site
city: Jossigny
country: France
facility: Research Site
city: La Rochelle Cedex
country: France
facility: Research Site
city: Le Chesnay
country: France
facility: Research Site
city: Le Coudray Cedex
country: France
facility: Research Site
city: Limoges Cedex
country: France
facility: Research Site
city: MARSEILLE Cedex 5
country: France
facility: Research Site
city: Metz Cedex 1
country: France
facility: Research Site
city: NICE Cedex 01
country: France
facility: Research Site
city: NIMES Cedex 9
country: France
facility: Research Site
city: Orléans Cedex 2
country: France
facility: Research Site
city: Paris
country: France
facility: Research Site
city: Pessac
country: France
facility: Research Site
city: Poitiers
country: France
facility: Research Site
city: Toulouse Cedex
country: France
facility: Research Site
city: TOURCOING cedex
country: France
facility: Research Site
city: Bad Krozingen
country: Germany
facility: Research Site
city: Bad Mergentheim
country: Germany
facility: Research Site
city: Bad Nauheim
country: Germany
facility: Research Site
city: Berlin
country: Germany
facility: Research Site
city: Bielefeld
country: Germany
facility: Research Site
city: Coburg
country: Germany
facility: Research Site
city: Deggingen
country: Germany
facility: Research Site
city: Dortmund
country: Germany
facility: Research Site
city: Dresden
country: Germany
facility: Research Site
city: Essen
country: Germany
facility: Research Site
city: Esslingen
country: Germany
facility: Research Site
city: Frankfurt
country: Germany
facility: Research Site
city: Hamburg
country: Germany
facility: Research Site
city: Heidelberg
country: Germany
facility: Research Site
city: Kassel
country: Germany
facility: Research Site
city: Kiel
country: Germany
facility: Research Site
city: Leipzig
country: Germany
facility: Research Site
city: Limburg
country: Germany
facility: Research Site
city: Ludwigshafen
country: Germany
facility: Research Site
city: Lübeck
country: Germany
facility: Research Site
city: Mainz
country: Germany
facility: Research Site
city: Mönchengladbach
country: Germany
facility: Research Site
city: Ulm
country: Germany
facility: Research Site
city: Warendorf
country: Germany
facility: Research Site
city: Witten
country: Germany
facility: Research Site
city: Ballasagyarmat
country: Hungary
facility: Research Site
city: Budapest
country: Hungary
facility: Research Site
city: Békéscsaba
country: Hungary
facility: Research Site
city: Cegléd
country: Hungary
facility: Research Site
city: Debrecen
country: Hungary
facility: Research Site
city: Eger
country: Hungary
facility: Research Site
city: Gyula
country: Hungary
facility: Research Site
city: Kalocsa
country: Hungary
facility: Research Site
city: Kecskemét
country: Hungary
facility: Research Site
city: Mosonmagyaróvár
country: Hungary
facility: Research Site
city: Nyíregyháza
country: Hungary
facility: Research Site
city: Pécs
country: Hungary
facility: Research Site
city: Sopron
country: Hungary
facility: Research Site
city: Szeged
country: Hungary
facility: Research Site
city: Szekszárd
country: Hungary
facility: Research Site
city: Szolnok
country: Hungary
facility: Research Site
city: Székesfehérvár
country: Hungary
facility: Research Site
city: Zalaegerszeg
country: Hungary
facility: Research Site
city: Albano Laziale
country: Italy
facility: Research Site
city: Bari
country: Italy
facility: Research Site
city: Benevento
country: Italy
facility: Research Site
city: Brescia
country: Italy
facility: Research Site
city: Carpi
country: Italy
facility: Research Site
city: Catania
country: Italy
facility: Research Site
city: Genova
country: Italy
facility: Research Site
city: Legnano
country: Italy
facility: Research Site
city: Lucca
country: Italy
facility: Research Site
city: Massa
country: Italy
facility: Research Site
city: Milano
country: Italy
facility: Research Site
city: Napoli
country: Italy
facility: Research Site
city: Osio Sotto frazione di Zingoni
country: Italy
facility: Research Site
city: Parma
country: Italy
facility: Research Site
city: Pavia
country: Italy
facility: Research Site
city: Perugia
country: Italy
facility: Research Site
city: Pescara
country: Italy
facility: Research Site
city: Pisa
country: Italy
facility: Research Site
city: Reggio Emilia
country: Italy
facility: Research Site
city: Roma
country: Italy
facility: Research Site
city: Rozzano
country: Italy
facility: Research Site
city: S Maria Capua Vetere
country: Italy
facility: Research Site
city: San Remo
country: Italy
facility: Research Site
city: Sassari
country: Italy
facility: Research Site
city: Sessa Aurunca
country: Italy
facility: Research Site
city: Siena
country: Italy
facility: Research Site
city: Sorrento NA
country: Italy
facility: Research Site
city: Vimercate
country: Italy
facility: Research Site
city: Akishima-shi
country: Japan
facility: Research Site
city: Amagasaki-shi
country: Japan
facility: Research Site
city: Beppu-shi
country: Japan
facility: Research Site
city: Chuo-ku
country: Japan
facility: Research Site
city: Daito-shi
country: Japan
facility: Research Site
city: Fukui-shi
country: Japan
facility: Research Site
city: Funabashi-shi
country: Japan
facility: Research Site
city: Gifu-shi
country: Japan
facility: Research Site
city: Hamamatsu-shi
country: Japan
facility: Research Site
city: Himeji-shi
country: Japan
facility: Research Site
city: Imabari-shi
country: Japan
facility: Research Site
city: Isehara-shi
country: Japan
facility: Research Site
city: Kamogawa-shi
country: Japan
facility: Research Site
city: Kanazawa-shi
country: Japan
facility: Research Site
city: Kawachinagano-shi
country: Japan
facility: Research Site
city: Kisarazu-shi
country: Japan
facility: Research Site
city: Komatsushima-shi
country: Japan
facility: Research Site
city: Koriyama-shi
country: Japan
facility: Research Site
city: Kumamoto-shi
country: Japan
facility: Research Site
city: Kure-shi
country: Japan
facility: Research Site
city: Kusatsu-shi
country: Japan
facility: Research Site
city: Kyoto-shi
country: Japan
facility: Research Site
city: Maebashi-shi
country: Japan
facility: Research Site
city: Matsue-shi
country: Japan
facility: Research Site
city: Matsumoto-shi
country: Japan
facility: Research Site
city: Matsuyama-shi
country: Japan
facility: Research Site
city: Meguro-ku
country: Japan
facility: Research Site
city: Miyazaki-shi
country: Japan
facility: Research Site
city: Osaka-shi
country: Japan
facility: Research Site
city: Saga-shi
country: Japan
facility: Research Site
city: Sagamihara-shi
country: Japan
facility: Research Site
city: Saitama-shi
country: Japan
facility: Research Site
city: Sakai-shi
country: Japan
facility: Research Site
city: Sakaide-shi
country: Japan
facility: Research Site
city: Sapporo-shi
country: Japan
facility: Research Site
city: Sayama-shi
country: Japan
facility: Research Site
city: Shimada-shi
country: Japan
facility: Research Site
city: Shinagawa-ku
country: Japan
facility: Research Site
city: Shizuoka-shi
country: Japan
facility: Research Site
city: Suwa-shi
country: Japan
facility: Research Site
city: Takarazuka-shi
country: Japan
facility: Research Site
city: Takasaki-shi
country: Japan
facility: Research Site
city: Takatsuki-shi
country: Japan
facility: Research Site
city: Tomakomai-shi
country: Japan
facility: Research Site
city: Toyonaka-shi
country: Japan
facility: Research Site
city: Ueda-shi
country: Japan
facility: Research Site
city: Wakayama-shi
country: Japan
facility: Research Site
city: Wako-shi
country: Japan
facility: Research Site
city: Yatsushiro-shi
country: Japan
facility: Research Site
city: Yokohama-shi
country: Japan
facility: Research Site
city: Bucheon-si
country: Korea, Republic of
facility: Research Site
city: Busan
country: Korea, Republic of
facility: Research Site
city: Cheongju
country: Korea, Republic of
facility: Research Site
city: Daegu
country: Korea, Republic of
facility: Research Site
city: Daejeon
country: Korea, Republic of
facility: Research Site
city: Gwangju
country: Korea, Republic of
facility: Research Site
city: Jeonju
country: Korea, Republic of
facility: Research Site
city: Seongnam-si
country: Korea, Republic of
facility: Research Site
city: Seoul
country: Korea, Republic of
facility: Research Site
city: Suwon-si
country: Korea, Republic of
facility: Research Site
city: Uijeongbu
country: Korea, Republic of
facility: Research Site
city: Wonju-si
country: Korea, Republic of
facility: Research Site
city: Almere
country: Netherlands
facility: Research Site
city: Amersfoort
country: Netherlands
facility: Research Site
city: Amsterdam
country: Netherlands
facility: Research Site
city: Arnhem
country: Netherlands
facility: Research Site
city: Beverwijk
country: Netherlands
facility: Research Site
city: Breda
country: Netherlands
facility: Research Site
city: Delft
country: Netherlands
facility: Research Site
city: Den Haag
country: Netherlands
facility: Research Site
city: Den Helder
country: Netherlands
facility: Research Site
city: Deventer
country: Netherlands
facility: Research Site
city: Drachten
country: Netherlands
facility: Research Site
city: EDE
country: Netherlands
facility: Research Site
city: Eindhoven
country: Netherlands
facility: Research Site
city: Goes
country: Netherlands
facility: Research Site
city: Groningen
country: Netherlands
facility: Research Site
city: Hardenberg
country: Netherlands
facility: Research Site
city: Heerenveen
country: Netherlands
facility: Research Site
city: Heerlen
country: Netherlands
facility: Research Site
city: Helmond
country: Netherlands
facility: Research Site
city: Hilversum
country: Netherlands
facility: Research Site
city: Hoofddorp
country: Netherlands
facility: Research Site
city: Hoogeveen
country: Netherlands
facility: Research Site
city: Leiderdorp
country: Netherlands
facility: Research Site
city: Maastricht
country: Netherlands
facility: Research Site
city: Nieuwegein
country: Netherlands
facility: Research Site
city: Nijmegen
country: Netherlands
facility: Research Site
city: OSS
country: Netherlands
facility: Research Site
city: Roosendaal
country: Netherlands
facility: Research Site
city: Rotterdam
country: Netherlands
facility: Research Site
city: Schiedam
country: Netherlands
facility: Research Site
city: Shertogenbosch
country: Netherlands
facility: Research Site
city: Sittardgeleen
country: Netherlands
facility: Research Site
city: Sneek
country: Netherlands
facility: Research Site
city: Tiel
country: Netherlands
facility: Research Site
city: Tilburg
country: Netherlands
facility: Research Site
city: Veldhoven
country: Netherlands
facility: Research Site
city: Bergen
country: Norway
facility: Research Site
city: Bodo
country: Norway
facility: Research Site
city: Bodø
country: Norway
facility: Research Site
city: Flekkefjord
country: Norway
facility: Research Site
city: Hamar
country: Norway
facility: Research Site
city: Levanger
country: Norway
facility: Research Site
city: Lillehammer
country: Norway
facility: Research Site
city: Nesttun
country: Norway
facility: Research Site
city: Oslo
country: Norway
facility: Research Site
city: Skien
country: Norway
facility: Research Site
city: Tromsø
country: Norway
facility: Research Site
city: Tynset
country: Norway
facility: Research Site
city: Arequipa
country: Peru
facility: Research Site
city: Callao
country: Peru
facility: Research Site
city: Lima
country: Peru
facility: Research Site
city: San Borja
country: Peru
facility: Research Site
city: Trujillo
country: Peru
facility: Research Site
city: Cebu City
country: Philippines
facility: Research Site
city: Fuente Osmena Cebu City
country: Philippines
facility: Research Site
city: Iloilo City
country: Philippines
facility: Research Site
city: Las Pinas City
country: Philippines
facility: Research Site
city: Lipa City
country: Philippines
facility: Research Site
city: Mandaluyong City
country: Philippines
facility: Research Site
city: Manila
country: Philippines
facility: Research Site
city: Pasig City
country: Philippines
facility: Research Site
city: Quezon City
country: Philippines
facility: Research Site
city: Quezon
country: Philippines
facility: Research Site
city: San Juan
country: Philippines
facility: Research Site
city: Białystok
country: Poland
facility: Research Site
city: Bielsko Biala
country: Poland
facility: Research Site
city: Bydgoszcz
country: Poland
facility: Research Site
city: Chorzow
country: Poland
facility: Research Site
city: Gdańsk
country: Poland
facility: Research Site
city: Gdynia
country: Poland
facility: Research Site
city: Giżycko
country: Poland
facility: Research Site
city: Kraków
country: Poland
facility: Research Site
city: Legnica
country: Poland
facility: Research Site
city: Lubin
country: Poland
facility: Research Site
city: Nowa Sól
country: Poland
facility: Research Site
city: Olsztyn
country: Poland
facility: Research Site
city: Opole
country: Poland
facility: Research Site
city: Ostrów Mazowiecka
country: Poland
facility: Research Site
city: Oława
country: Poland
facility: Research Site
city: Piotrkow
country: Poland
facility: Research Site
city: Poznań
country: Poland
facility: Research Site
city: Płock
country: Poland
facility: Research Site
city: Skierniewice
country: Poland
facility: Research Site
city: Sobótka
country: Poland
facility: Research Site
city: Sokolka
country: Poland
facility: Research Site
city: Szczecin
country: Poland
facility: Research Site
city: Tarnów
country: Poland
facility: Research Site
city: Torun
country: Poland
facility: Research Site
city: Toruń
country: Poland
facility: Research Site
city: Warszawa
country: Poland
facility: Research Site
city: Wrocław
country: Poland
facility: Research Site
city: Włocławek
country: Poland
facility: Research Site
city: Łańcut
country: Poland
facility: Research Site
city: Łódź
country: Poland
facility: Research Site
city: Łęczna
country: Poland
facility: Research Site
city: Bacau
country: Romania
facility: Research Site
city: Braila
country: Romania
facility: Research Site
city: Brasov
country: Romania
facility: Research Site
city: Bucharest
country: Romania
facility: Research Site
city: Bucuresti
country: Romania
facility: Research Site
city: Buzau
country: Romania
facility: Research Site
city: Cluj Napoca
country: Romania
facility: Research Site
city: Craiova
country: Romania
facility: Research Site
city: Deva
country: Romania
facility: Research Site
city: Focsani
country: Romania
facility: Research Site
city: Iasi
country: Romania
facility: Research Site
city: Pitesti
country: Romania
facility: Research Site
city: Sibiu
country: Romania
facility: Research Site
city: Suceava
country: Romania
facility: Research Site
city: Tg. Mures
country: Romania
facility: Research Site
city: Timisoara
country: Romania
facility: Research Site
city: Ekaterinburg
country: Russian Federation
facility: Research Site
city: Gatchina
country: Russian Federation
facility: Research Site
city: Kazan
country: Russian Federation
facility: Research Site
city: Krasnodar
country: Russian Federation
facility: Research Site
city: Moscow
country: Russian Federation
facility: Research Site
city: Nizhnii Novgorod
country: Russian Federation
facility: Research Site
city: Novosibirsk
country: Russian Federation
facility: Research Site
city: Perm
country: Russian Federation
facility: Research Site
city: Saint Petersburg
country: Russian Federation
facility: Research Site
city: Saint-Petersburg
country: Russian Federation
facility: Research Site
city: Saratov
country: Russian Federation
facility: Research Site
city: St.-Petersburg,
country: Russian Federation
facility: Research Site
city: St.-Petersburg
country: Russian Federation
facility: Research Site
city: St.Petersburg
country: Russian Federation
facility: Research Site
city: StPetersburg
country: Russian Federation
facility: Research Site
city: Vladikavkaz
country: Russian Federation
facility: Research Site
city: Volgograd
country: Russian Federation
facility: Research Site
city: Banska Bystrica
country: Slovakia
facility: Research Site
city: Bardejov
country: Slovakia
facility: Research Site
city: Bratislava
country: Slovakia
facility: Research Site
city: Komarno
country: Slovakia
facility: Research Site
city: Kosice
country: Slovakia
facility: Research Site
city: Liptovsky Hradok
country: Slovakia
facility: Research Site
city: Liptovsky Mikulas
country: Slovakia
facility: Research Site
city: Martin
country: Slovakia
facility: Research Site
city: Nitra
country: Slovakia
facility: Research Site
city: Partizanske
country: Slovakia
facility: Research Site
city: Piestany
country: Slovakia
facility: Research Site
city: Povazska Bystrica
country: Slovakia
facility: Research Site
city: Presov
country: Slovakia
facility: Research Site
city: Ruzomberok
country: Slovakia
facility: Research Site
city: Trnava
country: Slovakia
facility: Research Site
city: Zilina
country: Slovakia
facility: Research Site
city: Alberton
country: South Africa
facility: Research Site
city: Bloemfontein
country: South Africa
facility: Research Site
city: Cape Town
country: South Africa
facility: Research Site
city: Centurion
country: South Africa
facility: Research Site
city: Durban
country: South Africa
facility: Research Site
city: Gatesville
country: South Africa
facility: Research Site
city: George
country: South Africa
facility: Research Site
city: Johannesburg
country: South Africa
facility: Research Site
city: Kempron Park
country: South Africa
facility: Research Site
city: Panorama
country: South Africa
facility: Research Site
city: Parow
country: South Africa
facility: Research Site
city: Pretoria
country: South Africa
facility: Research Site
city: Somerset West
country: South Africa
facility: Research Site
city: Soweto
country: South Africa
facility: Research Site
city: Worcester
country: South Africa
facility: Research Site
city: Almeria
country: Spain
facility: Research Site
city: Aviles
country: Spain
facility: Research Site
city: Barcelona
country: Spain
facility: Research Site
city: Bilbao
country: Spain
facility: Research Site
city: Don Benito (Badajoz)
country: Spain
facility: Research Site
city: Hospitalet de Llobregat(Barcel
country: Spain
facility: Research Site
city: Madrid
country: Spain
facility: Research Site
city: Majadahonda
country: Spain
facility: Research Site
city: Málaga
country: Spain
facility: Research Site
city: Oviedo
country: Spain
facility: Research Site
city: Palma de Mallorca
country: Spain
facility: Research Site
city: Sabadell
country: Spain
facility: Research Site
city: San Sebastian de los Reyes
country: Spain
facility: Research Site
city: Santiago(A Coruña)
country: Spain
facility: Research Site
city: Sevilla
country: Spain
facility: Research Site
city: Valencia
country: Spain
facility: Research Site
city: Eksjö
country: Sweden
facility: Research Site
city: Göteborg
country: Sweden
facility: Research Site
city: Jönköping
country: Sweden
facility: Research Site
city: Linkoping
country: Sweden
facility: Research Site
city: Ljungby
country: Sweden
facility: Research Site
city: Lund
country: Sweden
facility: Research Site
city: Molndal
country: Sweden
facility: Research Site
city: Stockholm
country: Sweden
facility: Research Site
city: Sundsvall
country: Sweden
facility: Research Site
city: Umea
country: Sweden
facility: Research Site
city: Västerås
country: Sweden
facility: Research Site
city: Örebro
country: Sweden
facility: Research Site
city: Östersund
country: Sweden
facility: Research Site
city: Adana
country: Turkey
facility: Research Site
city: Ankara
country: Turkey
facility: Research Site
city: Istanbul
country: Turkey
facility: Research Site
city: Izmir
country: Turkey
facility: Research Site
city: Malatya
country: Turkey
facility: Research Site
city: Mersin
country: Turkey
facility: Research Site
city: Dnepropetrovsk
country: Ukraine
facility: Research Site
city: Donetsk
country: Ukraine
facility: Research Site
city: Kharkiv
country: Ukraine
facility: Research Site
city: Kharkov
country: Ukraine
facility: Research Site
city: Kiev
country: Ukraine
facility: Research Site
city: Kyiv
country: Ukraine
facility: Research Site
city: Lviv
country: Ukraine
facility: Research Site
city: Uzhgorod
country: Ukraine
facility: Research Site
city: Vinnitsa
country: Ukraine
facility: Research Site
city: Zaporozye
country: Ukraine
facility: Research Site
city: Airdrie
country: United Kingdom
facility: Research Site
city: Antrim
country: United Kingdom
facility: Research Site
city: Belfast
country: United Kingdom
facility: Research Site
city: Blackpool
country: United Kingdom
facility: Research Site
city: Bournemouth
country: United Kingdom
facility: Research Site
city: Brighton
country: United Kingdom
facility: Research Site
city: Bristol
country: United Kingdom
facility: Research Site
city: Coventry
country: United Kingdom
facility: Research Site
city: Dundee
country: United Kingdom
facility: Research Site
city: East Kilbride
country: United Kingdom
facility: Research Site
city: Ely
country: United Kingdom
facility: Research Site
city: Hastings
country: United Kingdom
facility: Research Site
city: London
country: United Kingdom
facility: Research Site
city: Manchester
country: United Kingdom
facility: Research Site
city: Middlesborough
country: United Kingdom
facility: Research Site
city: Northampton
country: United Kingdom
facility: Research Site
city: Nottingham
country: United Kingdom
facility: Research Site
city: Peterborough
country: United Kingdom
facility: Research Site
city: Rotherham
country: United Kingdom
facility: Research Site
city: Sheffield
country: United Kingdom
facility: Research Site
city: Swansea
country: United Kingdom
facility: Research Site
city: Torquay
country: United Kingdom
facility: Research Site
city: York
country: United Kingdom
facility: Research Site
Study officials:
affiliation: The TIMI Study Group
name: Eugene Braunwald, MD
role: STUDY_CHAIR
affiliation: The TIMI Study Group
name: Marc Sabatine, MD, MPh
role: PRINCIPAL_INVESTIGATOR
References:
citation: Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Jensen EC, Magnani G, Bansilal S, Fish MP, Im K, Bengtsson O, Oude Ophuis T, Budaj A, Theroux P, Ruda M, Hamm C, Goto S, Spinar J, Nicolau JC, Kiss RG, Murphy SA, Wiviott SD, Held P, Braunwald E, Sabatine MS; PEGASUS-TIMI 54 Steering Committee and Investigators. Long-term use of ticagrelor in patients with prior myocardial infarction. N Engl J Med. 2015 May 7;372(19):1791-800. doi: 10.1056/NEJMoa1500857. Epub 2015 Mar 14.
citation: Bonaca MP, Im K, Magnani G, Bansilal S, Dellborg M, Storey RF, Bhatt DL, Steg PG, Cohen M, Johanson P, Braunwald E, Sabatine MS. Patient selection for long-term secondary prevention with ticagrelor: insights from PEGASUS-TIMI 54. Eur Heart J. 2022 Dec 21;43(48):5037-5044. doi: 10.1093/eurheartj/ehac402.
citation: Natale P, Palmer SC, Saglimbene VM, Ruospo M, Razavian M, Craig JC, Jardine MJ, Webster AC, Strippoli GF. Antiplatelet agents for chronic kidney disease. Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD008834. doi: 10.1002/14651858.CD008834.pub4.
citation: Bergmark BA, Bhatt DL, Steg PG, Budaj A, Storey RF, Gurmu Y, Kuder JF, Im K, Magnani G, Oude Ophuis T, Hamm C, Spinar J, Kiss RG, Van de Werf FJ, Montalescot G, Johanson P, Braunwald E, Sabatine MS, Bonaca MP. Long-Term Ticagrelor in Patients With Prior Coronary Stenting in the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2021 Sep 7;10(17):e020446. doi: 10.1161/JAHA.120.020446. Epub 2021 Aug 21.
citation: Magnani G, Ardissino D, Im K, Budaj A, Storey RF, Steg PG, Bhatt DL, Cohen M, Oude Ophius T, Goudev A, Parkhomenko A, Kamensky G, Angiolillo DJ, Lopez-Sendon J, Johanson P, Braunwald E, Sabatine MS, Bonaca MP. Predictors, Type, and Impact of Bleeding on the Net Clinical Benefit of Long-Term Ticagrelor in Stable Patients With Prior Myocardial Infarction. J Am Heart Assoc. 2021 Feb 16;10(4):e017008. doi: 10.1161/JAHA.120.017008. Epub 2021 Feb 9.
citation: Furtado RHM, Venkateswaran RV, Nicolau JC, Gurmu Y, Bhatt DL, Storey RF, Steg PG, Magnani G, Goto S, Dellborg M, Kamensky G, Isaza D, Aylward P, Johanson P, Bonaca MP. Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 May 18;9(10):e015785. doi: 10.1161/JAHA.119.015785. Epub 2020 May 15.
citation: Gencer B, Li XS, Gurmu Y, Bonaca MP, Morrow DA, Cohen M, Bhatt DL, Steg PG, Storey RF, Johanson P, Wang Z, Hazen SL, Sabatine MS. Gut Microbiota-Dependent Trimethylamine N-oxide and Cardiovascular Outcomes in Patients With Prior Myocardial Infarction: A Nested Case Control Study From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 May 18;9(10):e015331. doi: 10.1161/JAHA.119.015331. Epub 2020 May 5.
citation: Furtado RHM, Nicolau JC, Magnani G, Im K, Bhatt DL, Storey RF, Steg PG, Spinar J, Budaj A, Kontny F, Corbalan R, Kiss RG, Abola MT, Johanson P, Jensen EC, Braunwald E, Sabatine MS, Bonaca MP. Long-term ticagrelor for secondary prevention in patients with prior myocardial infarction and no history of coronary stenting: insights from PEGASUS-TIMI 54. Eur Heart J. 2020 May 1;41(17):1625-1632. doi: 10.1093/eurheartj/ehz821.
citation: Dellborg M, Bonaca MP, Storey RF, Steg PG, Im KA, Cohen M, Bhatt DL, Oude Ophuis T, Budaj A, Hamm C, Spinar J, Kiss RG, Lopez-Sendon J, Kamensky G, Van de Werf F, Ardissino D, Kontny F, Montalescot G, Johanson P, Bengtsson O, Himmelmann A, Braunwald E, Sabatine MS. Efficacy and safety with ticagrelor in patients with prior myocardial infarction in the approved European label: insights from PEGASUS-TIMI 54. Eur Heart J Cardiovasc Pharmacother. 2019 Oct 1;5(4):200-206. doi: 10.1093/ehjcvp/pvz020.
citation: Bonaca MP, Wiviott SD, Morrow DA, Steg PG, Hamm C, Bhatt DL, Storey RF, Cohen M, Kuder J, Im K, Magnani G, Budaj A, Nicolau JC, Parkhomenko A, Lopez-Sendon J, Dellborg M, Diaz R, Van de Werf F, Corbalan R, Goudev A, Jensen EC, Johanson P, Braunwald E, Sabatine MS. Reduction in Subtypes and Sizes of Myocardial Infarction With Ticagrelor in PEGASUS-TIMI 54. J Am Heart Assoc. 2018 Nov 20;7(22):e009260. doi: 10.1161/JAHA.118.009260.
citation: Bansilal S, Bonaca MP, Cornel JH, Storey RF, Bhatt DL, Steg PG, Im K, Murphy SA, Angiolillo DJ, Kiss RG, Parkhomenko AN, Lopez-Sendon J, Isaza D, Goudev A, Kontny F, Held P, Jensen EC, Braunwald E, Sabatine MS, Oude Ophuis AJ. Ticagrelor for Secondary Prevention of Atherothrombotic Events in Patients With Multivessel Coronary Disease. J Am Coll Cardiol. 2018 Feb 6;71(5):489-496. doi: 10.1016/j.jacc.2017.11.050.
citation: Cavallari I, Morrow DA, Creager MA, Olin J, Bhatt DL, Steg PG, Storey RF, Cohen M, Scirica BS, Piazza G, Goodrich EL, Braunwald E, Sabatine MS, Bonaca MP. Frequency, Predictors, and Impact of Combined Antiplatelet Therapy on Venous Thromboembolism in Patients With Symptomatic Atherosclerosis. Circulation. 2018 Feb 13;137(7):684-692. doi: 10.1161/CIRCULATIONAHA.117.031062. Epub 2017 Oct 30.
citation: Bonaca MP, Storey RF, Theroux P, Steg PG, Bhatt DL, Cohen MC, Im K, Murphy SA, Magnani G, Ophuis TO, Rudah M, Parkhomenko A, Isaza D, Kamensky G, Goudev A, Montalescot G, Jensen EC, Johanson P, Braunwald E, Sabatine MS. Efficacy and Safety of Ticagrelor Over Time in Patients With Prior MI in PEGASUS-TIMI 54. J Am Coll Cardiol. 2017 Sep 12;70(11):1368-1375. doi: 10.1016/j.jacc.2017.07.768.
citation: Magnuson EA, Li H, Wang K, Vilain K, Shafiq A, Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Braunwald E, Sabatine MS, Cohen DJ; PEGASUS-TIMI 54 Trial Investigators. Cost-Effectiveness of Long-Term Ticagrelor in Patients With Prior Myocardial Infarction: Results From the PEGASUS-TIMI 54 Trial. J Am Coll Cardiol. 2017 Aug 1;70(5):527-538. doi: 10.1016/j.jacc.2017.05.063.
citation: Thomas MR, Angiolillo DJ, Bonaca MP, Ajjan RA, Judge HM, Rollini F, Franchi F, Ahsan AJ, Bhatt DL, Kuder JF, Steg PG, Cohen M, Muthusamy R, Sabatine MS, Storey RF. Consistent platelet inhibition with ticagrelor 60 mg twice-daily following myocardial infarction regardless of diabetes status. Thromb Haemost. 2017 May 3;117(5):940-947. doi: 10.1160/TH16-09-0703. Epub 2017 Mar 16.
citation: Bonaca MP, Goto S, Bhatt DL, Steg PG, Storey RF, Cohen M, Goodrich E, Mauri L, Ophuis TO, Ruda M, Spinar J, Seung KB, Hu D, Dalby AJ, Jensen E, Held P, Morrow DA, Braunwald E, Sabatine MS. Prevention of Stroke with Ticagrelor in Patients with Prior Myocardial Infarction: Insights from PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54). Circulation. 2016 Sep 20;134(12):861-71. doi: 10.1161/CIRCULATIONAHA.116.024637. Epub 2016 Aug 30.
citation: Bonaca MP, Bhatt DL, Oude Ophuis T, Steg PG, Storey R, Cohen M, Kuder J, Im K, Magnani G, Budaj A, Theroux P, Hamm C, Spinar J, Kiss RG, Dalby AJ, Medina FA, Kontny F, Aylward PE, Jensen EC, Held P, Braunwald E, Sabatine MS. Long-term Tolerability of Ticagrelor for the Secondary Prevention of Major Adverse Cardiovascular Events: A Secondary Analysis of the PEGASUS-TIMI 54 Trial. JAMA Cardiol. 2016 Jul 1;1(4):425-32. doi: 10.1001/jamacardio.2016.1017.
citation: Held P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10.
citation: Bonaca MP, Bhatt DL, Storey RF, Steg PG, Cohen M, Kuder J, Goodrich E, Nicolau JC, Parkhomenko A, Lopez-Sendon J, Dellborg M, Dalby A, Spinar J, Aylward P, Corbalan R, Abola MTB, Jensen EC, Held P, Braunwald E, Sabatine MS. Ticagrelor for Prevention of Ischemic Events After Myocardial Infarction in Patients With Peripheral Artery Disease. J Am Coll Cardiol. 2016 Jun 14;67(23):2719-2728. doi: 10.1016/j.jacc.2016.03.524. Epub 2016 Apr 1.
citation: Bhatt DL, Bonaca MP, Bansilal S, Angiolillo DJ, Cohen M, Storey RF, Im K, Murphy SA, Held P, Braunwald E, Sabatine MS, Steg PG. Reduction in Ischemic Events With Ticagrelor in Diabetic Patients With Prior Myocardial Infarction in PEGASUS-TIMI 54. J Am Coll Cardiol. 2016 Jun 14;67(23):2732-2740. doi: 10.1016/j.jacc.2016.03.529. Epub 2016 Apr 1.
citation: Bonaca MP, Bhatt DL, Steg PG, Storey RF, Cohen M, Im K, Oude Ophuis T, Budaj A, Goto S, Lopez-Sendon J, Diaz R, Dalby A, Van de Werf F, Ardissino D, Montalescot G, Aylward P, Magnani G, Jensen EC, Held P, Braunwald E, Sabatine MS. Ischaemic risk and efficacy of ticagrelor in relation to time from P2Y12 inhibitor withdrawal in patients with prior myocardial infarction: insights from PEGASUS-TIMI 54. Eur Heart J. 2016 Apr 7;37(14):1133-42. doi: 10.1093/eurheartj/ehv531. Epub 2015 Oct 21.
citation: Bonaca MP, Bhatt DL, Braunwald E, Cohen M, Steg PG, Storey RF, Held P, Jensen EC, Sabatine MS. Design and rationale for the Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54 (PEGASUS-TIMI 54) trial. Am Heart J. 2014 Apr;167(4):437-444.e5. doi: 10.1016/j.ahj.2013.12.020. Epub 2014 Jan 6.