Clinical trial NCT04902001: Role of Mechanical Load on Metabolic Exercise Adaptations in Response to Weight Loss in Obese Adolescents: The POWELL Study
Official title: Role of Mechanical Load on Metabolic Exercise Adaptations in Response to Weight Loss in Obese Adolescents: The POWELL Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pediatric Obesity
Keywords: energy expenditure
weight loss
obesity
adolescents
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
First posted: 2021-05-26
Enrollment: 21
Sex: ALL
Minimum age (years): 12
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: One group of adolescents with obesity
Primary purpose: BASIC_SCIENCE

Brief summary: While interdisciplinary weight loss intervention have been shown successful among adolescents with obesity, a weight regain is most of the time observed within the following weeks or months. The aim of the present project will be to better identify the independent role played by both the metabolic and mechanical load and their modification during weight loss, on the energy expenditure and energy metabolism of adolescents with obesity.

Detailed description: A total of 28 adolescents with obesity will be recruited from our local inpatient pediatric obesity centers. Before their weight loss intervention the adolescents will complete two experimental visits. During the first visit, anthropometric and body composition measurements will be performed. Then the participants will be asked to complete a walking exercise on a treadmill during the second visit. Their energy expenditure and substrate oxidation will be assessed by indirect calorimetry. They will have to walk at 5 different walking speeds. Then, they will follow a 12-week weight loss intervention. By the end of this intervention, their body composition will be assessed and they will be asked to perform the same walking exercise. On a separate occasion (randomly assigned) they will have to repeat this walking exercise while carrying a load corresponding of their weight loss.

Eligibility criteria: Inclusion Criteria:

* being aged 12-16 years old
* no contraindication to physical exercise
* no cardiovascular disease
* BMI above the 97th percentile
* candidate to a weight loss intervention

Exclusion Criteria:

* surgery and medical conditions preventing them to perform the intervention
* Weight loss during the previous 6 months
* medication that could interfere with energy metabolism.
* pregnancy
* regular tobacco and alcool use

Primary outcomes:
measure: Change in Energy Expenditure between before and after weight loss
timeFrame: before and after the 12-week weight loss
Secondary outcomes:
measure: change in lipid oxidation between before and after weight loss
timeFrame: before and after the 12-week weight loss
measure: change in Fat mass between before and after weight loss
timeFrame: before and after the 12-week weight loss
measure: change physical activity preferences between before and after weight loss
timeFrame: before and after the 12-week weight loss intervention
measure: Change in Energy Expenditure between the unloaded and loaded walking test
timeFrame: after the 12_week weight loss
measure: Change in lipid oxidation between the unloaded and loaded walking test
timeFrame: after the 12_week weight loss
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU clermont-ferrand
Study officials:
affiliation: University Hospital, Clermont-Ferrand
name: Yves Boirie
role: PRINCIPAL_INVESTIGATOR
References: