Clinical trial NCT03518567: Behavioral Economic Analysis of Demand for Marijuana
Official title: Behavioral Economic Analysis of Demand for Marijuana
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Marijuana Smoking
Lead sponsor: Brown University
Sponsor class: OTHER
First posted: 2018-05-08
Enrollment: 133
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: This laboratory study will employ a multi-session experimental design to examine the behavioral economic demand for marijuana, by studying effect of marijuana administration (High THC) on demand for marijuana, and marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly.

Detailed description: This laboratory study will employ a multi-session experimental design to examine craving for marijuana, the effect of marijuana administration (High THC) on behavioral economic demand for marijuana, and marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly. The relationship between hypothetical and actual demand for marijuana will be examined. We will also investigate relationship between demand for marijuana and indices of marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly to obtain a final sample of 85 with complete data (15% of attrition). Participants will be tested at a baseline session and during two experimental sessions (an ad libitum marijuana smoking session and a marijuana smoking topography session). This study will confirm the utility of the hypothetical marijuana purchase task as a reliable and valid tool for assessing behavioral economic marijuana demand.

Eligibility criteria: Inclusion Criteria:

* marijuana use at least 8 times in the past month on average and at least monthly for the past 6 months
* English-speaking
* negative urine toxicology screen for drugs other than marijuana
* non-treatment seeking
* purchase of marijuana at least twice in the past 6 months to confirm familiarity with the construct to be measured

Exclusion Criteria:

* positive pregnancy test
* nursing
* inability to use contraception during the study
* poor physical health
* positive breath alcohol concentration
* diagnosis of a current affective disorder, psychosis, and panic disorder
* self-report of past serious adverse reaction to marijuana
* current psychotropic drug use
* smoking more than 20 tobacco cigarettes per day
* inability to abstain from marijuana for 15 hours
* body mass index outside 18.5-30 kg/m2 range

Primary outcomes:
measure: Validity of the Marijuana Purchase Task (MPT)
timeFrame: Duration of the experimental session (i.e., 60 minutes)
Secondary outcomes:
measure: Change in Marijuana Craving Questionnaire (MCQ)
timeFrame: The MCQ will be administered pre- and post- marijuana smoking during the experimental session, up to 6 hours
measure: Marijuana Smoking Topography
timeFrame: Marijuana smoking topography indices will be collected during the 1-hour ad libitum marijuana smoking topography experimental session.
Other outcomes:
Locations:
city: Providence
country: United States
facility: Brown University
state: Rhode Island
Study officials:
affiliation: Brown University
name: Elizabeth Aston, PhD
role: PRINCIPAL_INVESTIGATOR
References: