Clinical trial NCT06280443: Sarcopenia in Chronic Lung Diseases
Official title: Epidemiological Study of Sarcopenia in Patients With Chronic Lung Diseases: A Prospective Registry Cohort Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Sarcopenia
COPD
Asthma
ILD
Lead sponsor: Taichung Veterans General Hospital
Sponsor class: OTHER
First posted: 2024-02-28
Enrollment: 300
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: * Baseline demographic characteristic, health behavior and exercise habits are collected by questionnaires.The main disease diagnosis, medication, clinical assessment questionnaire or biochemical examination and radiological examination results in outpatient visit are collected.
* According to the 2019 Asian Sarcopenia Consensus, participants are examined by SARC-Calf questionnaire, grip strength test, frailty index and a physical performance test,including sit-stand test, short physical performance battery (SPPB), gait speed test and six-minute walk test. Afterward, bioelectrical impedance analysis (BIA) are applied to all participants by to analyze body composition. Participants are classified into Sarcopenia group and severe Sarcopenia group.

Brief summary: Inclusion criteria A)Outpatients with COPD (chronic obstructive pulmonary disease) or ILD (interstitial lung disease) from department of Chest medicine in Taichung Veterans General Hospital, judged by the doctor that they do not need hospitalization or emergent treatment.

B) Patients who agree to provide the ID card number to the research team for usage as a link to the National Health Insurance research database and Health bank to explore the continuity of care and the use of medical resources

Detailed description: This study is a prospective, multi-center, and non-invasive cohort study. All participants are diagnosed with Asthma, COPD and ILD. We use SARC-Calf questionnaire, Frailty questionnaire and Grip strength as a tool for prescreen. According to the 2019 Asian Sarcopenia Consensus, participants are examined by SARC-Calf questionnaire, grip strength test and a physical performance test, including sit-stand test, short physical performance battery (SPPB), gait speed test and six-minute walk test. Bioelectrical impedance analysis (BIA) and Dual-energy X-ray absorptiometry (DXA) are applied to all participants by to analyze body composition. Participants are further classified into no Sarcopenia group, Sarcopenia group, and severe Sarcopenia group to derive the prevalence.

Eligibility criteria: Inclusion Criteria:

1. Outpatients with COPD (chronic obstructive pulmonary disease) or ILD (interstitial lung disease) from department of Chest medicine in Taichung Veterans General Hospital, judged by the doctor that they do not need hospitalization or emergent treatment.
2. Those who meet the conditions for frailty diagnosis after assessment by the Frailty Scale
3. Patients who agree to provide the ID card number to the research team for usage as a link to the National Health Insurance research database and Health bank to explore the continuity of care and the use of medical resources
4. Age\>=20

Exclusion Criteria:

1. Patients who refuse to sign the consent form
2. Patients who are bed ridden or unable to walk due to physical disabilities
3. Patients with terminal cancer or human acquired immunodeficiency syndrome
4. Patients with edema (pitting edema +2)

Primary outcomes:
measure: sarcopenia rate
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
Study officials:
References: