louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02492204: The Role of IL33/ST2 Axis in ARDS Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Lead sponsor: Hospital Universitari Vall d'Hebron Research Institute
Sponsor class: OTHER
First posted: 2015-07-08
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with ARDS criteria according to Berlin definition or risk pathologies

Brief summary: The main objective is the study of the role of IL33/ST2 axis in the pathogenesis of ARDS, it´s value as prognosis marker and as therapeutic target.


Eligibility criteria: Inclusion Criteria:

* ARDS
* Risk pathologies to develop ARDS (sepsis, pancreatitis, pneumonia, massive transfussion, politraumatics)

Exclusion Criteria:

* Age under 18
* Pregnancy
* Undergoing a clinical trial

Primary outcomes:
measure: Prognostic value of the IL-33/ST2 axis in patients with ARDS.
timeFrame: 60 days
Secondary outcomes:
measure: Value of IL33/ST2 axis to predict development of ARDS in risk patients
timeFrame: 60 days
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: Hospital Universitary Vall d´Hebron
Study officials:
References:
Clinical trial NCT01569204: Targeted BEACOPP Variants in Patients With Newly Diagnosed Advanced Classical Hodgkin Lymphoma
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Hodgkin Lymphoma
Lead sponsor: University of Cologne
Sponsor class: OTHER
First posted: 2012-04-03
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The Purpose of this trial is:

* to determine complete response rate (CRR) after six cycles of chemotherapy
* to determine complete remission rate (CR/CRr) as final treatment outcome after completion of treatment


Eligibility criteria: Inclusion Criteria:

* Histologically proven classical Hodgkin lymphoma
* First diagnosis, no previous treatment, age: 18-60 years
* Stage IIB with large mediastinal mass and/or extranodal lesions, stage III or IV disease

Exclusion Criteria:

* Composite lymphoma or nodular lymphocyte- predominant Hodgkin lymphoma (NLPHL)
* Previous malignancy
* Prior chemotherapy or radiation

Primary outcomes:
measure: Response rate (RR) after six cycles of chemotherapy
timeFrame: 18 weeks
measure: Complete remission rate (CR/CRr) as final treatment outcome after completion of treatment
timeFrame: 18 weeks
Secondary outcomes:
measure: Progression Free Survival (PFS)
timeFrame: 2 years
measure: Overall survival (OS)
timeFrame: 2 years
measure: Adverse event rate
timeFrame: 2 years
measure: Dose reduction rate
timeFrame: 18 weeks
measure: Relative dose intensity
timeFrame: 18 weeks
Other outcomes:
Locations:
city: Cologne
country: Germany
facility: 1st Dept. of Medicine, Cologne University Hospital
Study officials:
affiliation: University of Cologne, German Hodgkin Study Group
name: Peter Borchmann, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02708004: Clinical Study to Assess Body Fluid Homeostasis After Administration of ACT-132577 in Healthy Subjects
Official title: A Single-center, Double-blind, Randomized, Placebo-controlled, Two-way Crossover Study to Assess Body Fluid Homeostasis After Administration of ACT-132577 in Healthy Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy Subjects
Lead sponsor: Idorsia Pharmaceuticals Ltd.
Sponsor class: INDUSTRY
First posted: 2016-03-15
Enrollment: 24
Sex: MALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: This clinical study will be conducted to evaluate the effect of ACT-132577 on fluid homeostasis in healthy subjects.


Eligibility criteria: Inclusion Criteria:

* Signed informed consent
* Healthy on the basis of medical history, physical examination, cardiovascular assessments and hematology, clinical chemistry, and urinalysis tests
* Body mass index between 20.0 and 25.0 kg/m2 (inclusive) at screening

Exclusion Criteria:

- Any circumstances or conditions, which, in the opinion of the investigator, may affect full participation in the study or compliance with the protocol

Primary outcomes:
measure: Body weight
timeFrame: from Day 1 to Day 9
Secondary outcomes:
Other outcomes:
measure: Treatment-emergent Adverse Events
timeFrame: From Day 1 up to End-of-Study (i.e. for at least 25 days)
measure: Treatment-emergent Serious Adverse Events
timeFrame: From Screening (Day -3) up to Follow-up (i.e. for at least 49 days)
measure: Glomerular filtration rate (GFR)
timeFrame: At 0 h of Day 1, at 1 h, 2 h, 4 h, 6 h and 10 h of Day 1 & Day 9
measure: Fractional sodium excretion in 24 h urine samples [mmol per day]
timeFrame: At 0 h of Day 1, at 1 h, 2 h, 4 h, 6 h and 10 h of Day 1 & Day 9
measure: Fractional lithium excretion in 24 h urine samples [mmol per day]
timeFrame: At 0 h of Day 1, at 1 h, 2 h, 4 h, 6 h and 10 h of Day 1 & Day 9
Locations:
city: Lausanne
country: Switzerland
facility: Investigator Site Lausanne
Study officials:
affiliation: Idorsia Pharmaceuticals Ltd.
name: Clinical Trial
role: STUDY_DIRECTOR
References:
Clinical trial NCT06930404: Data Collection Study to Review Novel Methods for Diagnosing Obstructive Sleep Apnea
Official title: Innovation and Growth Network for Insightful Trends and Evaluation - Data Collection Study
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Obstructive Sleep Apnea (OSA)
Keywords: diagnosis
screening
Lead sponsor: ResMed
Sponsor class: INDUSTRY
First posted: 2025-04-16
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults who are being tested for obstructive sleep apnea

Brief summary: This study will collect data on a range of signals such as facial scans, videos (including speaking, blinking and swallowing) and heart rate variability to assess whether any of these measures are useful for diagnosing obstructive sleep apnea


Eligibility criteria: Inclusion Criteria:

Adults aged \>= 18 Ability to read and comprehend English

Exclusion Criteria:

* Previous diagnosis of OSA
* Respiratory diseases (such COPD, lung cancer, fibrosis of the lungs, lung injury)
* Subjects who are or may be pregnant, breastfeeding or within 6 weeks postpartum (which may impact HRV temporarily)
* Subjects with a pacemaker

Primary outcomes:
measure: Correlation of measurement and obstructive sleep apnea status
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06678204: Evaluating Illustrated Vs. Traditional Pamphlets for Enhancing Self-Care in Radiation Therapy Patients
Official title: Enhancing Self-care Strategies in Radiation Therapy Patients Through Diverse Smart and Flipped Education Compared to Traditional Text Booklets
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Radiation Therapy
Head Neck Cancer
Breast Cancer Invasive
Lead sponsor: Chung Shan Medical University
Sponsor class: OTHER
First posted: 2024-11-07
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: This quasi-experimental study utilized a pre- and post-test design with experimental and control groups to assess the effectiveness of optimized illustrated educational pamphlets in enhancing patient self-care cognition, satisfaction, and reducing anxiety. The experimental group received pamphlets with a combination of images and highlighted text, while the control group received traditional text-based pamphlets. The study targeted patients undergoing radiation therapy (RT) for head and neck or breast cancer for the first time. Pre-tests assessed baseline self-care cognition, and post-tests were conducted two weeks after treatment completion. The primary objective was to improve patient awareness and understanding of self-care, aiming to support both mental and physical well-being during RT.

Detailed description: This quasi-experimental, pre- and post-test comparison study was conducted from November 2, 2023, to August 31, 2024, at a medical center in Central Taiwan, following Institutional Review Board approval (IRB No. CS2-23058). A total of 200 first-time RT patients with head and neck or breast cancer were enrolled and randomized into two groups of 100 patients each. The experimental group received optimized illustrated pamphlets covering essential RT information, common side effects, and self-care principles, while the control group received traditional text-based pamphlets.

Eligibility criteria: Inclusion Criteria:

* participants with clear consciousness.
* participants could understand and comprehend Mandarin Chinese.

Exclusion Criteria:

* participants with impaired consciousness or decreased cognitive abilities.

Primary outcomes:
measure: Self-Care Cognition
timeFrame: Pre-test administered before treatment and post-test two weeks after treatment completion.
measure: Satisfaction with Educational Materials
timeFrame: Post-test administered two weeks after treatment completion.
measure: Anxiety Assessment
timeFrame: Pre-test administered before treatment and post-test two weeks after treatment completion.
Secondary outcomes:
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: Chung Shan Medical University
Study officials:
References:
Clinical trial NCT00092404: Safety, Tolerability, and Immunogenicity of an Investigational Vaccine With Recombinant Human Albumin (rHA) in Children 12 to 18 Months of Age (V205C-009)(COMPLETED)
Official title: A Comparison of the Safety, Tolerability, and Immunogenicity of V205C Manufactured With Recombinant Human Albumin (rHA) Versus V205C Manufactured With Pooled-Donor Human Serum Albumin (HSA) in Healthy Children 12 to 18 Months of Age
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Measles
Mumps
Rubella
Varicella
Lead sponsor: Merck Sharp & Dohme LLC
Sponsor class: INDUSTRY
First posted: 2004-09-27
Enrollment: 1210
Sex: ALL
Minimum age (years): 12
Maximum age (years): 18
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this trial is to study the safety and immune response to measles, mumps, and rubella in children who were vaccinated with an investigational measles-mumps-rubella live vaccine made with artificially made human protein.

Detailed description: The duration of treatment is 6 weeks.

Eligibility criteria: Inclusion Criteria:

* Healthy children 12 to 18 months of age

Exclusion Criteria:

* History or prior exposure to measles, mumps, or rubella
* History of allergic reactions to any component of the vaccines as evaluated by the study doctor

Primary outcomes:
measure: Antibody response rates to measles, mumps, and rubella at 6 weeks postvaccination
timeFrame: 6 weeks postvaccination
Secondary outcomes:
measure: Geometric mean titers to measles, mumps, and rubella by ELISA at 6 weeks postvaccination
timeFrame: 6 weeks postvaccination
Other outcomes:
Locations:
Study officials:
affiliation: Merck Sharp & Dohme LLC
name: Medical Monitor
role: STUDY_DIRECTOR
References:
citation: Wiedmann RT, Reisinger KS, Hartzel J, Malacaman E, Senders SD, Giacoletti KE, Shaw E, Kuter BJ, Schodel F, Musey LK. M-M-R((R))II manufactured using recombinant human albumin (rHA) and M-M-R((R))II manufactured using human serum albumin (HSA) exhibit similar safety and immunogenicity profiles when administered as a 2-dose regimen to healthy children. Vaccine. 2015 Apr 27;33(18):2132-40. doi: 10.1016/j.vaccine.2015.03.017. Epub 2015 Mar 18.
Clinical trial NCT06948604: Impact of Kegel Exercise on Post TURP Outcomes
Official title: Impact of Kegel Exercises on the Postoperative Outcomes of Patients Undergoing Transurethral Resection of the Prostate
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: BPH (Benign Prostatic Hyperplasia)
Keywords: Kegel exercise,TURP, Patient outcomes and BPH
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-04-29
Enrollment: 100
Sex: MALE
Minimum age (years): 45
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: how kegel exercise will reduce post TURP COMPLICATION and improve patient outcomes

Detailed description: patients will divided in to two group study and control, study group will perform kegel exercise pre and postoperative while control group receive routine care and followed for 6 month

Eligibility criteria: Inclusion Criteria:

* patient diagnosed with BPH and undergoing TURP
* Patient age range from 45-65years old
* Patient understand verbal and written instructions

Exclusion Criteria:

Patient confirmed diagnosis with prostate cancer (biopsy-PSA) Conversion to open prostatectomy Patient has cognitive impairment Patient has chronic cough /chronic bronchitis or asthma

Primary outcomes:
measure: International Prostate Symptom Score
timeFrame: within 3 month
Secondary outcomes:
measure: World Health Organization Performance Status Scale
timeFrame: within 6 month
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02406404: Change of Pulmonary Function After Incentive Spirometer Training in Children With Cerebral Palsy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cerebral Palsy
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2015-04-02
Enrollment: 35
Sex: ALL
Minimum age (years): 4
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study was designed to examine the effect of incentive spirometry in pulmonary rehabilitation of children with cerebral palsy. The incentive spirometer, a device that can help improve breathing and strengthen inspiratory muscles. If the patient assigned to training group, the subjects started to respiratory muscle strengthening exercise using incentive spirometry. The training was performed ten sessions daily, for 4 weeks. Respiratory function tests including forced vital capacity, forced expiratory volume in 1 second, Peak cough flow, maximal phonation time were compared before interventions and at the end of exercise.


Eligibility criteria: Inclusion Criteria:

* male or female, 4 to 18 years
* patients who are committed to comply with protocol-required procedures
* GMFCS (Gross motor function classification system) level II, III, IV
* Stable medical condition in the investigator's opinion
* Acceptable chest radiologic result who has no evidence of pulmonary disease

Exclusion Criteria:

* Any uncontrolled clinically significant medical condition other than the one under study
* Patients with cognitive impairment who are unable to comply with protocol-required procedure
* Patients with presence or history of tracheostomy
* Patients who are taking medications that can affect respiratory function

Primary outcomes:
measure: Forced vital capacity
timeFrame: within 3 days after respiratory muscle training
Secondary outcomes:
measure: forced expiratory volume in 1 second
timeFrame: within 3 days after respiratory muscle training
measure: Peak cough flow
timeFrame: within 3 days after respiratory muscle training
measure: maximal phonation time
timeFrame: within 3 days after respiratory muscle training
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Severance hospital
Study officials:
References:
Clinical trial NCT05829304: A Comparative Clinical and Radiographic Study Of Collagen Based Pulpotomy in Cariously Exposed Vital Primary Molars
Official title: A Comparative Clinical and Radiographic Study Of Collagen Based Pulpotomy Versus MTA Pulpotomy in Cariously Exposed Vital Primary Molars
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Dental Caries in Children
Lead sponsor: Cairo University
Sponsor class: OTHER
Collaborators: name: Cairo University
First posted: 2023-04-25
Enrollment: 19
Sex: ALL
Minimum age (years): 4
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Teeth that will be included in the current trial will be randomly assigned one of the experimental groups using closed white envelopes (simple randomization 1:1 ratio).
Primary purpose: TREATMENT

Brief summary: To assess post operative pain and survival rate after collagen based pulpotomy versus MTA pulpotomy in children with vital primary molars.

Detailed description: Pulpotomy of vital primary molars is indicated when caries removal results in pulp exposure. Treatment approaches consist of devitalization using formocresol, preservation using ferric sulfate and regeneration using mineral trioxide aggregate of the remaining pulp tissue have been utilized to date. The ideal pulpotomy medicament would be biocompatible and bactericidal, in addition, to promote the healing of the root pulp and be compatible with the physiological process of root resorption.

Collagen, which is available for dental implication, is already sterilized and also reinforced with antibiotic particles to efficiently aid in regeneration and repair without any contaminations. The collagen particles can be sterilized by various methods like irradiation, dry heat, and ethylene oxide, among which irradiation is the most frequently used method as it does not affect the structural stability

Eligibility criteria: Inclusion Criteria:

1. Primary molar tooth not more than one-third of root resorption.
2. Children with bilateral deep dental caries approximating the pulp in primary molars assessed both clinically and radiographically.
3. systemically healthy.
4. cooperative patients who will comply to follow up visits.

Exclusion Criteria:

1. Children with medical, physical, or mental conditions.
2. Primary molars with any congenital deformities.
3. Previously accessed teeth.
4. At operative procedure haemorrhage control is unachievable after pulpotomy.

Primary outcomes:
measure: postoperative pain
timeFrame: 3 days
Secondary outcomes:
measure: Absence of internal root resorption
timeFrame: up to 24 week
measure: absence of swelling
timeFrame: up to 24 week
Other outcomes:
Locations:
Study officials:
References:
citation: Anandan V, Inbanathan J, Saket P, Krishnamoorthy V, Gandhi S, Chandrababu VK. Assessment of Clinical and Radiographic Success Rate of Formocresol-based Pulpotomy versus Collagen-based Pulpotomy: An In Vivo Study. J Contemp Dent Pract. 2021 Jun 1;22(6):680-685.
Clinical trial NCT04728204: Internet-based Psychotherapy for Depressed Elderly
Official title: Internet-based Cognitive Behavioral Therapy for Depressed Elderly: a Two-armed Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Depression
Keywords: Depression
Internet-based cognitive behaviour therapy
Elderly
eHealth
Lead sponsor: Vilnius University
Sponsor class: OTHER
Collaborators: name: Linkoeping University
First posted: 2021-01-28
Enrollment: 84
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants will be randomized to either control or intervention group. Participants in the control group will receive the same treatment after the intervention group is finished with the treatment.
Primary purpose: TREATMENT

Brief summary: This study aims to evaluate the effectiveness of internet-based cognitive behavioral therapy (CBT) for depressed elderly.

Detailed description: Individuals of age 60+ with symptoms of depression will be assessed before the study. At week 0, participants who meet eligibility requirements will be randomized either to intervention group which will participate in an 8-week internet-based modular CBT or to a delayed treatment control group.

Eligibility criteria: Inclusion Criteria:

* depressive symptoms
* have access to a computer/tablet/smartphone and to the internet
* have good knowledge of the Lithuanian language

Exclusion Criteria:

* alcohol addiction
* presently in any other psychological treatment
* severe depression
* suicidal ideation
* significant change in psychiatric medication (during last 6 weeks)

Primary outcomes:
measure: Patient Health Questionnaire (PHQ-9)
timeFrame: Pre-treatment, week 8, 3, 12 and 24 months post-treatment
measure: Geriatric Depression Scale (GDS)
timeFrame: Pre-treatment, week 8, 3, 12 and 24 months post-treatment
Secondary outcomes:
measure: Generalized Anxiety Disorder-7 (GAD-7)
timeFrame: Pre-treatment, week 8, 3, 12 and 24 months post-treatment
measure: The World Health Organisation- Five Well-Being Index (WHO-5)
timeFrame: Pre-treatment, week 8, 3, 12 and 24 months post-treatment
Other outcomes:
measure: The Alcohol Use Disorders Identification Test (AUDIT)
timeFrame: Pre-treatment
Locations:
city: Vilnius
country: Lithuania
facility: Vilnius University
Study officials:
affiliation: Vilnius University
name: Jonas Eimontas, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Eimontas J, Pakalniskiene V, Biliunaite I, Andersson G. A tailored Internet-delivered modular intervention based on cognitive behavioral therapy for depressed older adults: a study protocol for a randomized controlled trial. Trials. 2021 Dec 16;22(1):925. doi: 10.1186/s13063-021-05903-4.
Clinical trial NCT00538304: A Study of the Safety and Efficacy of Bimatoprost in Patients With Glaucoma or Ocular Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Glaucoma
Ocular Hypertension
Lead sponsor: Allergan
Sponsor class: INDUSTRY
First posted: 2007-10-02
Enrollment: 222
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A one month study which will determine the safety and efficacy of bimatoprost eye drops in patients with glaucoma or ocular hypertension


Eligibility criteria: Inclusion Criteria:

* Chronic glaucoma or ocular hypertension
* IOP controlled on Xalatan

Exclusion Criteria:

* Uncontrolled medical conditions
* Known hypersensitivity to study medications

Primary outcomes:
measure: Change From Baseline in Mean Peak Macroscopic Conjunctival Hyperemia at Month 1
timeFrame: Baseline, Month 1
Secondary outcomes:
measure: Percentage of Patients With an Increase in Macroscopic Conjunctival Hyperemia in Either Eye at Month 1
timeFrame: Month 1
measure: Change From Baseline in Mean Intraocular Pressure (IOP) at Month 1
timeFrame: Baseline, Month 1
measure: Percentage of Physicians Who Were Very or Extremely Willing to Continue Patient on Drug, if Drug Were Marketed at Month 1
timeFrame: Month 1
measure: Percentage of Patients Who Were Very or Extremely Willing to Use This Glaucoma Medication at Month 1
timeFrame: Month 1
measure: Percentage of Patients Who Reported No Change in the Appearance of Their Eyes Since the Beginning of the Study at Month 1
timeFrame: Month 1
Other outcomes:
Locations:
city: Atlanta
country: United States
state: Georgia
Study officials:
affiliation: Allergan
name: Medical Director
role: STUDY_DIRECTOR
References:
citation: Craven ER, Liu CC, Batoosingh A, Schiffman RM, Whitcup SM. A randomized, controlled comparison of macroscopic conjunctival hyperemia in patients treated with bimatoprost 0.01% or vehicle who were previously controlled on latanoprost. Clin Ophthalmol. 2010 Dec 6;4:1433-40. doi: 10.2147/OPTH.S14915.