Clinical trial NCT02545894: An Evaluation of a New Nonverbal Treatment for Global Aphasia
Official title: An Investigation Into the Effect of a Novel, Non Verbal, Cognitive Treatment on Functional Communication in Global Aphasia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke
Lead sponsor: University College, London
Sponsor class: OTHER
First posted: 2015-09-10
Enrollment: 6
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: People with global aphasia (PwGA) post stroke have little to no meaningful communication abilities (ie limited comprehension, spoken language, reading and writing abilities).A proportion of PwGA will also have limited abilities to use any alternative means of communication e.g. gesture, pictures or computer devices. There is a suggestion in the literature that this is because of co-occurring cognitive deficits. The consequence is that these clients are unable to reliably communicate even their basic needs.This is commonly known as having no functional communication abilities. Such PwGA tend not to respond to standard speech and language therapy interventions.

This research will investigate the effect of a new cognitive intervention designed to improve basic functional communication abilities. The treatment will be nonverbal and involve computer and paperbased tasks ordered hierarchically from basic to more complex tasks. Six to eight participants will take part. All their sessions will take place in their own home. For some this may be a care home. They will first complete a diagnostic communication assessment in order for baseline abilities to be established. Further formal language and cognitive assessments will be conducted over a period of 6 weeks. A relative/friend will complete a questionnaires about mood/communication. The PwGA will also be videoed interacting with the research student e.g. looking at a magazine, completing a jigsaw, answering questions and making choices non-verbally.

The participants then receive the new intervention 3 times a week for 6 consecutive weeks. All intervention sessions will be videoed. Then participants will be reassessed over 2 weeks using the same assessments as prior to the intervention. The questionnaire with their relative/friend and videoed activity session will also be repeated. After a twelve week break the participant will be videoed interacting with the research student complete some of the assessments again and their relative will re-complete the questionnaires.


Eligibility criteria: Inclusion Criteria:

* have global aphasia as diagnosed by an SLT
* have little or no verbal output
* inconsistent single word comprehension
* little or no ability to read or write
* little or no ability to use alternative modes of communication
* Little or no ability to make choices in function
* no diagnosis/history of a progressive neurological condition
* no diagnosis of hearing loss
* no diagnosis/history of a mental health condition
* English as a first language

Exclusion Criteria:

* has another form of aphasia
* is able to consistently express basic needs non-verbally or verbally.
* is able to participate in communicative interaction with a familiar other
* has a history of a progressive neurological condition
* has hearing loss
* has a diagnosis/history of a mental health condition
* does not have English as a first language.

Primary outcomes:
measure: American Speech and Hearing Association -Functional Assessment of Communication
timeFrame: 27 weeks
measure: Constructed Interaction Task
timeFrame: 27 weeks
Secondary outcomes:
measure: Aphasia Screening Test
timeFrame: 14 weeks
measure: Mood Screen
timeFrame: 27 weeks
measure: Pyramids and Palm Trees Test
timeFrame: 27 weeks
measure: Wisconsin Card Sorting Test
timeFrame: 14 weeks
measure: Butt Non verbal reasoning test
timeFrame: 27 weeks
measure: Western Aphasia Battery cognitive sub test
timeFrame: 14 weeks
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: University College London, Research Dept of Language and Cognition
Study officials:
affiliation: UCL
name: Suzanne Beeke, PhD
role: PRINCIPAL_INVESTIGATOR
References: