Clinical trial NCT06585865: Strength Training and Resveratrol
Official title: Resveratrol-mediated Changes in Extracellular Vesicle microRNA Cargo as a Novel Contributor to Resistance Training-induced Skeletal Muscle Adaptations in Older Adults
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Sarcopenia
Anabolic Resistance
Keywords: Resistance training
Aging
Resveratrol
Sarcopenia
Extracellular Vesicles
MicroRNAs
Lead sponsor: Texas Tech University
Sponsor class: OTHER
Collaborators: name: National Strength and Conditioning Association
First posted: 2024-09-19
Enrollment: 36
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: After pre-testing, participants will be randomized to supplement with resveratrol (500 mg) or placebo for 14 weeks. All participants will complete two 6-week blocks of supervised strength training (full body, 3 days/week); each block will be followed by one week of testing.
Primary purpose: PREVENTION

Brief summary: The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether circulating vehicles of inter-organ communication (extracellular vesicles) and their cargo might help explain those responses. The investigators will also examine whether resveratrol supplementation improves blood vessel function and cognitive function (brain health) in response to strength training.

Detailed description: After screening and providing informed consent, participants (healthy older adults, age 60+, minimally active) will be familiarized with the procedures and undergo pre-testing. After pre-testing, participants will be assigned to supplement with resveratrol or placebo (double-blinded) daily while undergoing a strength training intervention. Strength training will be performed 3x/week for two 6-week blocks, and each visit will be supervised by a member of the study team. An additional week of testing will follow each of the two 6-week blocks.

Eligibility criteria: Inclusion Criteria:

* Age 60+
* Minimally active (less than 1 hour of structured exercise/week other than walking)
* No resistance training for the previous 6 months
* Not currently taking resveratrol supplements
* Stable medication, supplement, dietary, and physical activity regimens for the previous 3 months and no plans to change throughout the study period

Exclusion Criteria:

* Medical complications that could increase risk during exercise (e.g., cardiovascular disease, uncontrolled hypertension, type 1 or 2 diabetes, orthopedic contraindication to exercise, kidney disease, etc.)
* Cannabis or nicotine use
* Consume more than 7 alcohol-containing beverages per week

Primary outcomes:
measure: Circulating extracellular vesicle microRNA profile
timeFrame: During pre-, mid-, and post-testing (each separated by about 6 weeks)
measure: Muscle torque
timeFrame: During pre-, mid-, and post-testing (each separated by about 6 weeks)
measure: Muscle fatigability
timeFrame: During pre-, mid-, and post-testing (each separated by about 6 weeks)
measure: Muscle strength
timeFrame: During pre-, mid-, and post-testing (each separated by about 6 weeks)
measure: Appendicular skeletal muscle mass index
timeFrame: During pre-, mid-, and post-testing (each separated by about 6 weeks)
Secondary outcomes:
measure: Waist-to-hip ratio
timeFrame: During pre-, mid-, and post-testing (each separated by about 6 weeks)
measure: Vascular function
timeFrame: During pre-, mid-, and post-testing (each separated by about 6 weeks)
measure: Cognitive function
timeFrame: During pre-, mid-, and post-testing (each separated by about 6 weeks)
measure: Grip strength
timeFrame: During pre-, mid-, and post-testing (each separated by about 6 weeks)
measure: Lower body strength/endurance
timeFrame: During pre-, mid-, and post-testing (each separated by about 6 weeks)
measure: Gait speed
timeFrame: During pre-, mid-, and post-testing (each separated by about 6 weeks)
Other outcomes:
Locations:
city: Lubbock
country: United States
facility: Department of Kinesiology &amp; Sport Management, Texas Tech University
state: Texas
Study officials:
affiliation: Texas Tech University
name: Danielle E Levitt, PhD
role: PRINCIPAL_INVESTIGATOR
References: