Clinical trial NCT06812767: Risk Factors at Chronic Non-communicable Diseases in People of Working Age
Official title: Risk Factors at Chronic Non-communicable Diseases in People of Working Age
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Chronic Non-communicable Disease
Keywords: arterial hypertension
coronary heart disease
cerebrovascular disease
malignant tumors
chronic obstructive pulmonary disease
asthma
diabetes mellitus
environment
smoking
alcohol consumption
unbalanced diet
hypodynamia
obesity
overweight
dyslipidemia
hyperglycemia
microalbuminuria
Lead sponsor: National Medical Research Center for Therapy and Preventive Medicine
Sponsor class: OTHER_GOV
First posted: 2025-02-06
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: The study is planned to include all working citizens who meet the inclusion criteria and have come for preventive examination. In total, at least 2,000 people are planned to be included in the study. All participants will be given informed consent to participate in the clinical trial

Brief summary: Objectives: to study the clinical and demographic characteristics of working age persons, to highlight the main factors of non-communicable diseases (NCDs), to identify NCDs with physical examination, laboratory tests, electrocardiography and ultrasound imaging, to develop a corporate prevention program for the company to reduce the risk of complications of NCDs.

Research stages:

1. Questionnaire to identify socio-demographic, behavioral, hereditary, psycho-emotional risk factors of NCDs
2. Laboratory tests (analysis of glucose and cholesterol in the capillary blood, detection of microalbuminuria), diagnostic tests (electrocardiography, and carotid artery ultrasound)
3. Evaluation of the results of questionnaires and surveys. Recommendations for lifestyle modification and follow-up in a local healthcare department

Detailed description: Currently the emphasis in preventive medicine is also on health of the working population, which is a key state policy in the Russian Federation. Health of working citizens is an important factor in the development and safety of the production sector, but it is also the key to health and well-being of all other groups - children and older generations - that is, in fact, the fundamental factor for social development. Therefore, the integration of health-saving technologies into all areas of working life, including production and work activities, is particularly important. In today's world, it is very important that everyone actively participate in the preservation the health of the individual and its high awareness. Awareness of risk factors for chronic non-communicable diseases and measures prevention throughout life is an important part of a healthy society. Monitoring the health of working citizens allows to predict the problem and take the necessary measures in a timely manner.

In the Russian Federation, medical screening is a complex system, including medical examination by physicians of several specialties and application of the necessary methods of examination to identify chronic non-communicable diseases and their risk factors at an early stage that are the main cause of disability and premature mortality in the country's population, and also to form health status groups and provide recommendations for patients. The examination is carried out once every three years and includes a set of methods of advanced examination to identify early on the most likely chronic non-communicable disease for a given age and gender. Regular checkups are the most important mass and highly effective medical technology of health savings.

The work of carrying out regular preventive examinations and check-ups is carried out by primary health care. Often the quality of such work is limited by manpower shortages, technological and logistical barriers. In modern conditions, these obstacles can be overcome by using mobile systems that include modern digital diagnostic technologies, Allow for more in-depth investigation and identification of risk factors not covered by the standard examination protocol. This will increase the coverage and detection of risk factors, which is an important component of the health saving of the working population

Eligibility criteria: Inclusion Criteria:

* employees of the company
* persons without NCDs diagnosis and not receiving permanent medication
* residents of the region of the Russian Federation where a factory with permanent or temporary registration is located

Exclusion Criteria:

* refusal to sign informed consent
* any NCDs requiring constant medication
* active cancer
* pulmonary embolism
* valve defects of the heart (except secondary mitral regurgitation)

Primary outcomes:
measure: prevalence of NCDs risk factors
timeFrame: on enrollment
measure: prevalence of NCDs
timeFrame: on enrollment
Secondary outcomes:
measure: Hospitalization
timeFrame: on enrollment
Other outcomes:
Locations:
city: Moscow
country: Russian Federation
facility: National Medical Research Center for Therapy and Preventive Medicine
Study officials:
affiliation: National Medical Research Center for Therapy and Preventive Medicine
name: Olga Dzhioeva, MD, PhD
role: STUDY_DIRECTOR
References: