Clinical trial NCT01397357: Cardiac Magnetic Resonance Utilities in the Evaluation of Ischemic Heart Disease
Official title: CARDIAC MAGNETIC RESONANCE UTILITIES IN THE EVALUATION OF ISCHEMIC HEART DISEASE: Topographical Correlation Between Ischemic Territory Injury and Coronary Angiography
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Myocardial Ischemia
Keywords: Cardiac magnetic resonance
Myocardial Ischemia
Coronary Artery Disease
suspected Myocardial Ischemia
Lead sponsor: Ettore Sansavini Health Science Foundation
Sponsor class: OTHER
First posted: 2011-07-19
Enrollment: 146
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who refer to the clinic within 12 months, with diagnosis of suspected coronary artery disease (CAD) or recurrent ischemic symptoms assessed by under-effort angina symptoms and/or cardiac conventional stress test, and the presence of at least two risk factors.

Brief summary: The purpose of this study is to evaluate CARDIAC MAGNETIC RESONANCE UTILITIES IN THE ISCHEMIC HEART DISEASE as topographical correlation between ischemic territory injury and coronary angiography.

Detailed description: Assessing the accuracy of Cardio-RM identifying ischemic territories and their correspondence to the presence of critical coronary lesions, comparing the presence, extent and regional inducible ischaemia in the Cardiac-MRI with the presence and characteristics of vascular lesions in coronary angiography.

In particular, the study aims to evaluate the correlation between topography and function of the ischemic area revealed by the resonance and coronary artery disease documented coronary angiography.

Eligibility criteria: Inclusion Criteria:

1. patients with suspected ischemic heart disease or recurrent Myocardial ischemic symptoms defined as:

   * presence of:

     * chest pain related to the effort lasting 5-20 minutes, and / or
     * positive stress test for inducible Myocardial ischemia
   * presence of at least one of the following risk factors: smoke family history of cardiovascular disease hypertension dyslipidemia diabetes mellitus NID / ID
2. no contraindications to perform coronary angiography
3. informed written consent to the processing of personal and sensible data, signed and dated by the patient.

Exclusion Criteria:

* Unstable angina;
* Severe aortic stenosis
* Hypertrophic cardiomyopathy
* Pacemaker and \\ or defibrillator
* Coronary stent implantation in 90 days before Cardiac MRI
* Intracranial metal clips
* Severe hypertension (systolic blood pressure\> 240 mmHg, and diastolic blood pressure above 120 mmHg)
* Ventricular thrombosis and \\ or atrial
* Aortic aneurysm and \\ or aortic dissection
* Myocarditis, endocarditis, pericarditis
* Critical stenosis of the left notes
* State of severe anxiety or claustrophobia
* Contraindications to the use of atropine (BAV advanced glaucoma, pyloric stenosis, prostatic hypertrophy)

Primary outcomes:
measure: Accuracy of Cardio-RM identifying ischemic territories
timeFrame: 1 month
Secondary outcomes:
measure: correlation between resonance and coronary artery disease documented coronary angiography.
timeFrame: 1 month
measure: topographic correlation between ischemic territory and coronary lesions
timeFrame: 1 month
Other outcomes:
Locations:
city: Cotignola
country: Italy
facility: Maria Cecilia Hospital
state: RA
Study officials:
References: