Clinical trial NCT00431301: Risk Factors for Progressive Supranuclear Palsy (PSP)
Official title: Genetic and Environmental Risk Factors for PSP
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Progressive Supranuclear Palsy
Keywords: Progressive Supranuclear Palsy
Epidemiology
Case-Control
Genetic
Environmental
Neurodegenerative Disease
Movement Disorders
Atypical Parkinsonism
Parkinson Plus
Steele-Richardson-Olszewski
PSP
Lead sponsor: University of Louisville
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
First posted: 2007-02-05
Enrollment: 942
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with clinically diagnosed Progressive Supranuclear Palsy and healthy controls

Brief summary: Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian movement disorder. This study will determine the role of specific genetic, occupational and environmental components in the development of PSP by evaluating patients with this disorder and age and gender matched controls.

Detailed description: This proposal will determine: (1) if there is an association between PSP and specific genes of interest; (2) if there is an association between PSP and occupational and/or environmental chemical exposures functionally or structurally similar to known parkinsonian toxicants; and (3) if hypertension or traumatic brain injury prior to symptom-onset is associated with PSP. To disentangle the complex etiology of PSP, this case-control multicenter study involves 500 PSP cases, 500 age/gender matched primary controls, and 500 secondary controls for genetic confirmation. Understanding the etiology of PSP may also help explain the causes of other related diseases such as Alzheimer's disease. This multidisciplinary team of movement disorder specialists, epidemiologists, geneticists, biostatisticians, industrial hygienist and toxicologist is well suited to unravel the etiology of PSP.

Eligibility criteria: Inclusion Criteria:

* PSP patients able to visit one of the screening sites for diagnostic confirmation and able to participate in a one hour telephone interview

Exclusion Criteria:

* No other major neurological disorders
* Unable to communicate by telephone

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama, Birmingham
state: Alabama
city: Los Angeles
country: United States
facility: UCLA
state: California
city: Aurora
country: United States
facility: University of Colorado
state: Colorado
city: Atlanta
country: United States
facility: Emory College of Medicine
state: Georgia
city: Chicago
country: United States
facility: Rush University
state: Illinois
city: Kansas City
country: United States
facility: University of Kansas
state: Kansas
city: Louisville
country: United States
facility: University of Louisville
state: Kentucky
city: Baltimore
country: United States
facility: University of Maryland
state: Maryland
city: Cleveland
country: United States
facility: Case Western University
state: Ohio
city: Toronto
country: Canada
facility: University of Toronto
state: Ontario
Study officials:
affiliation: University of Louisville
name: Irene Litvan, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kelley KD, Checkoway H, Hall DA, Reich SG, Cunningham C, Litvan I. Traumatic Brain Injury and Firearm Use and Risk of Progressive Supranuclear Palsy Among Veterans. Front Neurol. 2018 Jun 20;9:474. doi: 10.3389/fneur.2018.00474. eCollection 2018.