louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00453466: Group Empowerment of Battered Women as a Tool for Violence Prevention
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Domestic Violence
Keywords: women experiencing domestic violence
Lead sponsor: Ben-Gurion University of the Negev
Sponsor class: OTHER
First posted: 2007-03-29
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Intimate partner violence against women is a significant global health problem. This study was designed to test the hypothesis that a group intervention based on empowerment theory of Paolo Freire would be effective as a means to reduce the extent and prevent violence among women whose partners were violent toward them.

Detailed description: A randomized controlled trial (N=141) with two control groups (one individual psychotherapeutic treatment and the other a usual care group treatment) was conducted in a violence treatment center in the South of Israel The treatment protocol designed to empower battered women (EBW) was conducted with 12 groups over a period of two years. Assessments were made before, immediately following and at an 8 month follow up following the intervention.

Eligibility criteria: Inclusion Criteria:

* Women living in the south, who had approached the center for help as battered women
* Could fill out forms in Hebrew
* Aged 20 and above

Exclusion Criteria:

* Age younger than 20
* Not able to fill out forms in Hebrew
* Not living in the southern district of Israel

Primary outcomes:
measure: Conflict tactics scale, Posttraumatic stress scale for
measure: family violence
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Ben-Gurion University of the Negev
name: Julie G Cwikel, Ph.D.
role: STUDY_DIRECTOR
References:
Clinical trial NCT01284426: Natural History of Chronic Urticaria
Official title: The Natural History of Chronic Urticaria in Childhood: A Prospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Urticaria
Keywords: Chronic urticaria
Natural course
Remission
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2011-01-27
Enrollment: 94
Sex: ALL
Minimum age (years): 4
Maximum age (years): 15
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pediatric allergy clinic, Siriraj Hospital Mahidol University, Thailand, Children 4-15 years of age with chronic urticaria.

Brief summary: The purpose of this study is to examine the natural history of chronic urticaria in children and to identify the predictors for chronic urticaria remission.

Detailed description: A Prospective cohort study of 92 children who were diagnosed with chronic urticaria to investigate the natural course of chronic urticaria and to identify predictors of disease remission.

Eligibility criteria: Inclusion Criteria:

* Children 4-15 years of age with the diagnosis of chronic urticaria who were attending the pediatric allergy clinic, Siriraj Hospital Mahidol University, Thailand, from March 2003 to March 2009.

Exclusion Criteria:

* Children who had isolated physical urticaria, inability to be followed up, pregnancy, underlying diseases such as cardiovascular, hepatobiliary, and renal diseases.

Primary outcomes:
measure: Duration of Urticaria Until Remission Since Chronic Urticaria Was Diagnosed.
timeFrame: 6 years
Secondary outcomes:
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University
Study officials:
affiliation: Siriraj Hospital
name: Orathai Piboonpocanun, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Chansakulporn S, Pongpreuksa S, Sangacharoenkit P, Pacharn P, Visitsunthorn N, Vichyanond P, Jirapongsananuruk O. The natural history of chronic urticaria in childhood: a prospective study. J Am Acad Dermatol. 2014 Oct;71(4):663-8. doi: 10.1016/j.jaad.2014.05.069. Epub 2014 Jul 11.
Clinical trial NCT02025426: Phenylephrine Versus Ephedrine in Pre-eclampsia
Official title: Impact of Vasopressor Administration on Maternal and Neonatal Outcomes in Women With Pre-eclampsia
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE4
Conditions: Pre-eclampsia
Keywords: Cesarean delivery
Spinal Anesthesia
Lead sponsor: Duke University
Sponsor class: OTHER
First posted: 2014-01-01
Enrollment: 13
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Phenylephrine administration is associated with reductions in CO and SctO2 compared with ephedrine when used for blood pressure management in women with pre-eclampsia undergoing cesarean delivery under spinal anesthesia.


Eligibility criteria: Inclusion Criteria:

* English speaking
* Age ≥18 yrs
* Pre-eclampsia (mild, or severe)
* Non-laboring women
* CD under spinal anesthesia

Exclusion Criteria:

* Height \< 5'0"
* Allergy to phenylephrine or ephedrine, or any other standardized medication
* Severe Cardiac disease in pregnancy with marked functional limitations (NYHA Class III and IV)
* Patients on Monoamine Oxidase Inhibitors or Tricyclic Antidepressants
* History of recent amphetamine or cocaine use.
* Subject enrollment in another study involving a study medication within 30 days of CD
* Any other physical or psychiatric condition which may impair their ability to cooperate with study data collection

Primary outcomes:
measure: Cerebral Tissue Oxygen Saturation
timeFrame: Intraoperative from spinal placement till 10 min after delivery
Secondary outcomes:
measure: Cardiac Output
timeFrame: Intraoperative from spinal placement till 10 min after delivery
Other outcomes:
measure: Neonatal Umbilical Cord Gases, pCO2
timeFrame: Within 5 minutes after delivery
measure: Neonatal Umbilical Cord Gases, pH
timeFrame: Within 5 minutes after delivery
measure: Neonatal Umbilical Cord Gases, BE
timeFrame: Within 5 minutes after delivery
measure: Number of Participants With Intraoperative Hypotension
timeFrame: Intraoperatively from spinal placement till 10 minutes after delivery
measure: Number of Participants With Intraoperative Nausea
timeFrame: Intraoperatively from time of spinal placement until end of surgery
measure: Number of Participants With Intraoperative Vomiting
timeFrame: Intraoperatively from time of spinal placement until end of surgery
Locations:
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
Study officials:
affiliation: Duke University
name: Ashraf S Habib, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00468026: Evaluation of the ProstaPlant Prostate Stent Insertion in Ex Vivo Human Prostate
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Benign Prostatic Hyperplasia
Keywords: BPH
Prostate
Stent
Benign prostatic hyperplasia (BPH)
Lead sponsor: ProstaPlant Urology System Ltd.
Sponsor class: INDUSTRY
First posted: 2007-05-01
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this ex-vivo study is to evaluate the insertion procedure for the ProstaPlant implant in human prostates and the support that it supplies to the prostate.


Eligibility criteria: Inclusion Criteria:

* Males,
* 18 years old and up,
* Suffer from BPH,
* Candidate for radical prostatectomies

Exclusion Criteria:

* According to the physician's decision

Primary outcomes:
measure: This is a feasibility study, in which initial evaluation of stent insertion procedure is obtained
Secondary outcomes:
Other outcomes:
Locations:
city: Tel-Aviv
country: Israel
facility: "Asuta" Medical Center
Study officials:
affiliation: "Rabin" Medical Center - "Belinson" Campus - Urology Department
name: Jack Baniel, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03140826: Amplification and Selection of Antimicrobial Resistance in the Intestine II
Official title: Amplification and Selection of Antimicrobial Resistance in the Intestine II
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Antibiotic Selection Pressure
Lead sponsor: University Hospital Tuebingen
Sponsor class: OTHER
Collaborators: name: University Hospital of Cologne
First posted: 2017-05-04
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with hemato-oncological disease in neutropenia or with expected neutropenia

Brief summary: Stool samples will be collected from two groups of neutropenic patients in the case that a therapy with either meropenem or piperacillin/tazobactam is needed due to a suspected infection. The intestinal resistome will be determined and quantified using shotgun metagenomics. Based on this, regression models will be used to determine the actual selection pressure caused by these drugs, and both selective forces will be compared. The results will reveal if there is a drug that causes a lower selection pressure compared to the other. The study aims to generate knowledge that is required to design effective antibiotic stewardship programs.


Eligibility criteria: Inclusion Criteria:

* Patients with hemato-oncological disease in neutropenia or with expected neutropenia
* Need for treatment with meropenem or piperacillin-tazobactam

Exclusion Criteria:

* pregnancy
* HIV, HBV, HCV

Primary outcomes:
measure: Antibiotic Selection Pressure
timeFrame: under treatment, max. 10 days
Secondary outcomes:
Other outcomes:
Locations:
city: Cologne
country: Germany
facility: University Hospital Cologne
city: Tuebingen
country: Germany
facility: Institute of Medical Microbiology and Hygiene, University Hospital of Tuebingen
Study officials:
affiliation: University Tuebingen
name: Matthias Willmann, Prof. Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06986226: MultiCPR: The Influence of Ventilations on Mental Arithmetics
Official title: MultiCPR: The Influence of Ventilations on Mental Arithmetics
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Multitasking Behavior
Lead sponsor: Medical University of Vienna
Sponsor class: OTHER
First posted: 2025-05-22
Enrollment: 38
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this clinical study is to investigate how performing ventilations during pediatric resuscitation affects the ability to perform mental tasks. In particular, the effect on the participant's ability to perform dose calculations will be investigated. The aim is to draw conclusions about the effects of ventilations on other mental tasks.

How does the clinical trial work? This clinical trial will be conducted in several locations and will involve a total of 38 people. The study will be conducted by the Department of Anesthesiology of the Medical University of Vienna.

Participation in this clinical study is expected to last 30 minutes.

The following measures will be carried out exclusively for study reasons:

Depending on the sub-study you are participating in, different tasks will be performed:

Adult sub-study:

During this study, participants will be asked to perform mental arithmetic: Participants will be read a number every 2 seconds and have to add the last two in each case. The numbers are predetermined and randomly generated. At the end, we will evaluate how many results were correct.


Eligibility criteria: Inclusion:

* Healthy medical professionals trained in CPR (paramedics, prehospital emergency physicians, anesthesiologists, internal medicine doctors, nurses, midwifery students, pediatricians)
* CPR Training in the last four years
* Fit and rested.

Exclusion:

- Pregnant probands

Primary outcomes:
measure: Dose calculations
timeFrame: during 2x2 minutes of inclusion
Secondary outcomes:
measure: NASA-TLX
timeFrame: 4 minutes, 2 times in total per participant
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: Academic Simulation Center
Study officials:
References:
Clinical trial NCT06975826: A Comparison Between Two Laparoscopic Techniques in Management of Inguinal Hernias in Pediatrics
Official title: A Comparison Between the Percutaneous Internal Ring Suturing (PIRS) Technique and Laparoscopic Intraperitoneal Purse String Suture Sac Closure Technique in Pediatrics
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Inguinal Hernia
Pediatrics
Keywords: Laparscopic inguinal herniotomy
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-05-16
Enrollment: 50
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare between the use of the percutaneous internal ring suturing (PIRS) technique and the Laparoscopic intraperitoneal purse-string suture sac closure technique. in pediatrics \& evaluate the safety, efficacy feasibility ,operative time ,postoperative pain ,recurrence rate of both approaches.

Detailed description: Inguinal hernia repairs (IHRs) are one of the most common procedures performed by pediatric surgeons around the world. Although the open method remains the most common for pediatric IHR, laparoscopic IHR has increased dramatically between 2009 and 2018. Over a dozen different laparoscopic techniques have been developed .With the rise in popularity of laparoscopic IHR, many researchers have set out to examine the differences in efficacy of open IHR compared with various laparoscopic IHR techniques. However, there are few studies directly comparing different laparoscopic techniques. By determining outcome discrepancies among popular laparoscopic techniques for pediatric IHR, we can help improve surgical techniques, postoperative outcomes, and patient satisfaction.The proposed advantages of the laparoscopic approach include visualization of a contralateral PPV, identification of less common (direct, femoral, pantaloon) hernias ,diminished postoperative pain, more rapid return to normal function, and improved cosmesis. Two laparoscopic techniques that have gained popularity among pediatric surgeons in the past decade, the percutaneous internal ring suturing (PIRS) technique and Laparoscopic intraperitoneal purse string suture sac closure technique.

Eligibility criteria: Inclusion Criteria:

* 1. Age 1month to 18 years. 2. Denovo Inguinal Hernias. 3. Uncomplicated Inguinal Hernias.

Exclusion Criteria:

* 1. Complicated Inguinal Hernia 2. Age more than 18 Years 3. cases inwhich laparoscopic surgery is contraindicated 4. cases with collagen disease. 5. Recurrent Inguinal Hernia.

Primary outcomes:
measure: Operative time in both approaches
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
name: Almoataz Ahmed Eltayeb
role: STUDY_DIRECTOR
References:
Clinical trial NCT02470026: Noradrenergic Activity, Cognition and Major Depressive Disorder
Official title: Influences on Noradrenergic Activity for Cognition in Patients With Major Depressive Disorder
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Major Depressive Disorder
Early Life Trauma
Lead sponsor: Charite University, Berlin, Germany
Sponsor class: OTHER
First posted: 2015-06-12
Enrollment: 131
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This study investigates influences of nordadrenergic activity on cognition in patients with major depression regarding influences of early life stress.

Detailed description: Stress plays a major role in the development and maintenance of major depression disorder. Indeed, various studies demonstrated maladaptive changes in physiological stress regulation systems of depressive patients, i.e. in the hypothalamus-pituitary-adrenal axis and the locus coeruleus-noradrenergic system. On a central level, changes of the locus coeruleus-noradrenergic system have been demonstrated.This seems to be the case especially in depressive patients with early life traumata. Comparable to the hypothalamus-pituitary-adrenal axis, the locus coeruleus-noradrenergic system influences not only the physiological stress response, but has also central influence with effects on cognitive functions. Indeed, noradrenergic effects on cognitive functions such as attention, learning and memory have been demonstrated in healthy individuals. Even though deficits in cognitive domains are core symptoms of major depression, the relationship of the noradrenergic system and cognitive processes has rarely been investigated so far.

In this project, the investigators will examine noradrenergic influences via administration of the alpha2-receptor blocker yohimbine on cognitive and emotionally relevant processes in depressive patients and controls. Additionally, the investigators will examine the influence of early life traumata on these relationships. Thus, the investigators will examine participants with and without major depression and with and without early life stress.

Results of this study will improve the understanding of cognitive dysfunctions associated with the noradrenergic system in patients with major depression.

Eligibility criteria: Inclusion Criteria:

* diagnosis of major depression
* experience of early life trauma

Exclusion Criteria:

* severe illness
* Alzheimer´s
* schizophrenia
* bipolar disorder
* control group: - diagnosis of major depression/ experience of early life trauma

Primary outcomes:
measure: behavioral responses in two different conditions of noradrenergic stimulation
timeFrame: 2,5 hrs
measure: physiological responses in two different conditions of noradrenergic stimulation
timeFrame: 2,5 hrs
Secondary outcomes:
Other outcomes:
Locations:
city: Berlin
country: Germany
facility: Charite University
Study officials:
References:
Clinical trial NCT04313426: Chronic Pain Self-Management With Integrative Yoga Therapy (IYT)
Official title: Evaluating Community-Based Pain Self-Care Using Integrative Yoga Therapy (IYT): Quasi Experimental Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Pain
Chronic Nonmalignant Pain
Lead sponsor: Aarogyam UK
Sponsor class: OTHER
Collaborators: name: Hindu Swayamsevak Sangh (UK)
name: Leicester Ageing Together
First posted: 2020-03-18
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study was to evaluate efficacy of chronic pain self-management program in community settings to adopt Integrative Yoga Therapy (IYT).


Eligibility criteria: Inclusion Criteria:

* Older than 18 years old.
* having a chronic pain of more than 3 months of duration, no matter the aetiology.
* Capable of understanding and giving written informed consent.
* Significant levels of distress and disability related to the pain at the beginning of treatment

Exclusion Criteria:

* Intelectual disability or cognitive impairment
* Planning to move out of area
* Serious mental illness
* Drugs or substance abuse in the last 6 months
* Post surgery or scheduled for surgery
* Cancer related pain

Primary outcomes:
measure: Pain Intensity
timeFrame: From baseline to 6-week post intervention
Secondary outcomes:
measure: Anxiety and Depression
timeFrame: From baseline to 6-week post intervention
measure: Satisfaction with the treatment
timeFrame: From Baseline to 6-week post intervention
measure: General Quality of Life
timeFrame: From baseline to 6-week post intervention
Other outcomes:
Locations:
city: Leicester
country: United Kingdom
facility: Karyalaya
Study officials:
affiliation: Aarogyam UK
name: Neha Sharma, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Aarogyam UK
name: Jaydeep Joshi, BAMS
role: STUDY_DIRECTOR
affiliation: Hindu Swayamsevak Sangh
name: Usha Solanki
role: STUDY_CHAIR
affiliation: Leicester Ageing Together
name: Bharti Mistry
role: STUDY_CHAIR
References:
Clinical trial NCT04677426: 129Xe Gas Exchange Imaging in IPF and cHP: A Reliability Study
Official title: 129Xe Gas Exchange Imaging in IPF and cHP: A Reliability Study
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE2
Conditions: Idiopathic Pulmonary Fibrosis
Hypersensitivity Pneumonitis
Lead sponsor: University of Kansas Medical Center
Sponsor class: OTHER
Collaborators: name: Duke University
name: Children's Hospital Medical Center, Cincinnati
name: Boehringer Ingelheim
First posted: 2020-12-21
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: This research is a study to test the reliability of Hyperpolarized Xenon MRI (HXe MRI) as a biomarker in interstitial lung disease. The study is a non-randomized study to evaluate the test-retest performance of HXe MRI in Idiopathic Pulmonary Fibrosis (IPF) and chronic Hypersensitivity Pneumonitis (cHP) as a non-invasive biomarker of disease severity and prognosis. The study will include approximately 15 subjects with IPF, 15 subjects with cHP and 10 sex and age-matched normal controls performed across 3 sites.


Eligibility criteria: Inclusion Criteria:

* Adults \> 18 years of age
* Diagnosis of progressive chronic HP, IPF as determined by MDD discussion (historical or during screening period) OR normal control (no history of known lung disease, no abnormal parenchymal or airway findings on CT examination and no values outside of the normal for FVC, FEV1, TLC, and DLCO.)
* FVC % Predicted \>45%
* DLCO % Predicted \>30%
* Progressive lung disease as defined by one of the following criteria within 24 months of screening visit
* Relative decline in the FVC ≥ 10% of the predicted value
* Relative decline in the FVC of ≥ 5% - \< 10% of the predicted value and worsening of respiratory symptoms
* Relative decline in the FVC of ≥ 5% - \< 10% of the predicted value and an increased extent of fibrosis on prior clinical high-resolution CT
* Worsening of respiratory symptoms and an increased extent of fibrosis on high-resolution CT.

Exclusion Criteria:

* Stable FVC over 2-year period as determined by study physician
* Unstable cardiac condition within 6 months of screening as determined by study physician

Primary outcomes:
measure: RBC:Barrier Ratio
timeFrame: RBC:Barrier will be assessed at Baseline and at 6 months.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: