louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00516867: Does Sunbed Radiation With Mainly UVA Provoke Cutaneous Vitamin D Synthesis in Humans?
Official title: Sunbed Radiation Provoke Cutaneous Vitamin D Synthesis in Humans, a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Lead sponsor: Bispebjerg Hospital
Sponsor class: OTHER
Collaborators: name: Hvidovre University Hospital
First posted: 2007-08-16
Enrollment: 41
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: We would investigate in a controlled, randomized open study in the winter season: 1) If serum levels of vitamin D (25(OH)D) increase in subjects treated with sunbed with sunlamps emitting mainly UVA and only 0·5% or 1·4% UVB compared to non-sunbed treated controls 2) If yes, are the 25(OH)D serum levels then dependent on the UVB dose?


Eligibility criteria: Inclusion Criteria:

* Healthy
* Females
* Above 50 years
* Younger with serum concentration of 25(OH)D below 50nmol/l

Exclusion Criteria:

* No sunbed use last ½ year
* No sun holiday last ½ year
* No intake of vitamin D above 10 microgram/day

Primary outcomes:
measure: Serum concentration of 25(OH)D
timeFrame: 18 Days
Secondary outcomes:
measure: Serum concentration of PTH
timeFrame: 18 Days
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Bispebjerg Hospital
Study officials:
affiliation: Bispebjerg Hospital
name: Hans C Wulf, MD, DSc
role: STUDY_CHAIR
References:
Clinical trial NCT06544967: Differences Between Male and Femal Fetal Brain Biometry by Ultrasound
Official title: Sexual Dimorphism of The Fetal Brain Biometry: An Ultrasound-Based Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Fetal Brain Biometry by Ultrasound
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2024-08-09
Enrollment: 500
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: healthy women from 18 to 36 weeks gestation of pregnant cases aged from 18 to 40 years normal body mass index range from 18 to 25

Brief summary: Differences of fetal brain biometry as Biparietal diameter,Head circumference,Transcerebellar diameter, Cavum septum pellucidum as regard to fetal gender by ultrasound


Eligibility criteria: Inclusion Criteria:

* healthy women from 18 to 36 weeks gestation of pregnant cases aged from 18 to 40 years normal body mass index range from 18 to 25

Exclusion Criteria:

* Pregnant women with any chronic or systemic disease and fetuses with chromosome anomalies or developmental retardation were not included in the study

Primary outcomes:
measure: Fetal brain biometry
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Sohag university hospital
Study officials:
References:
Clinical trial NCT03172767: The Relationship Between School Readiness and Sensory Processing Disorder in Preterm Preschooler
Official title: The Relationship Between School Readiness and Sensory Processing Disorder in Preterm Preschooler
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sensory Deficit
Preterm Birth
Keywords: Preterm
Sensory processing
School Readiness
Lead sponsor: Gazi University
Sponsor class: OTHER
First posted: 2017-06-01
Enrollment: 60
Sex: ALL
Minimum age (years): 60
Maximum age (years): 78
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Preterm Preschoolers and Term Preschoolers

Brief summary: The study aims investigate sensory processing disorders and school readiness in pre-school preterm children and the relationship between sensory impairment and school readiness

Detailed description: A convenience of preterm and term preschoolers recruiting from Gazi University, Faculty of Health Science, Department of Physiotherapy and Rehabilitation. Each group contains 30 children. First, sociodemographic information and histories of children are obtaining. Ages and contact information of the parents are recording. Prenatal and natal risk factors of the mothers are querying. Gestational ages and height, weight, and head circumferences of babies at birth are recording. Number of pregnancies, live births and abortions, type of delivery, multiple pregnancies for mothers as well as consanguinity between parents are asking. Marmara Primary School Readiness Scale is using to evaluate mental-language development, socio-emotional development, physical development, self-care skills,math skills, science skills, voice exercises, line exercises and labyrinths. Sensory profile caregiver questionnaire screen for the senses (sensory processing), adjustment (modulation), behavioral and emotional responses. . All examination wiil be finished in the same day.

Eligibility criteria: Inclusion Criteria:

* No neurological diagnosis
* gestational age \< 37 weeks
* 60-78 months of age

Exclusion Criteria:

* Have a neurological diagnosis (such as cerebral palsy)
* Grade III or grade IV intraventricular hemorrhage
* Have undergone major surgery in neonatal period
* Mental retardation

Primary outcomes:
measure: Marmara Primary School Readiness Scale
timeFrame: 45 minutes
Secondary outcomes:
measure: Sensory profile caregiver questionnaire
timeFrame: 45 minutes
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gazı University
Study officials:
affiliation: study chair
name: Bülent Elbasan
role: STUDY_CHAIR
References:
Clinical trial NCT04051567: Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies
Official title: Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies--A Multicenter, Prospective, Open, Randomized, Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Twin Pregnancy
Preeclampsia
Preterm Birth
Fetal Growth Restriction
Lead sponsor: Ministry of Science and Technology of the People´s Republic of China
Sponsor class: OTHER_GOV
Collaborators: name: Peking University Third Hospital
name: Chongqing Medical Center for Women and Children
First posted: 2019-08-09
Enrollment: 425
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Twin pregnancies are associated with increased risk of perinatal adverse outcomes , including preeclampsia , fetal growth restriction , preterm premature rupture of membranes and preterm birth. Low-dose aspirin was recommend by American College of Obstetricians and Gynecologists (ACOG) during pregnancy. In this trial, the investigators suppose that aspirin used in twin-pregnancies could improve adverse pregnancy outcomes.


Eligibility criteria: Inclusion Criteria:

* Twin pregnancy diagnosed by ultrasound and maternal age ranged from 18 to 55 years, Gestational age was less than 16w

Exclusion Criteria:

* Diagnosed fetal anomalies, history of cervical cerclage, contraindications of aspirin, pre-existing renal or liver diseases or abnormal functions, coagulation disorders, history of PE, preterm birth or FGR, chronic hypertension

Primary outcomes:
measure: The incidence of preeclampsia, preterm birth, fetal growth restriction
timeFrame: after 30 weeks of gestional age
Secondary outcomes:
Other outcomes:
Locations:
city: Chongqing
country: China
facility: Hongbo,Qi
state: Chongqing
Study officials:
References:
Clinical trial NCT04899167: Noninvasive Evaluation of Renal Allograft Fibrosis by MRI
Official title: Noninvasive Evaluation of Renal Allograft Fibrosis by MRI
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Kidney Transplantation
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
First posted: 2021-05-24
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Prospective, unblinded, Parallel, imaging study
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to validate an MRI method to detect renal fibrosis in patients after kidney transplantation (KT).

Detailed description: The hypothesis underlying this proposal is that qMT reliably detects development of allograft fibrosis in human subjects after KT. To test this hypothesis, the qMT-derived bound pool fraction will be correlated with renal fibrosis as per biopsy in 20 patients 4 or 7 years after living donor KT. The bound pool fraction will also be compared to renal blood flow, oxygenation, and function, and the ability of qMT to provide consistent assessments of fibrosis tested at different magnetic field strengths. Two specific aims will test the hypotheses that: Specific Aim 1: qMT provides reliable and consequential assessment of fibrosis in human kidney allografts. Specific Aim 2: Renal fibrosis assessed by qMT in human kidney allografts is reproducible at 1.5 T and 3.0 T.

Eligibility criteria: Inclusion Criteria:

* Age 18-80 years
* Recipient of living donor kidney transplantation 4 or 7 years earlier
* Competent and able to provide written informed consent; Ability to comply with protocol

Exclusion Criteria:

* Patients have clinically significant medical conditions within the prior 6 months before: e.g. myocardial infarction, congestive heart failure, stroke, that would, in the opinion of the investigators, compromise the safety of the patient.
* Severe chronic liver, heart or lung disease
* Undergoing acute rejection
* Contra-indication to biopsy; bleeding disorders
* Chronic infection
* Any active malignancy and undergoing therapy
* Kidney or ureteric stone
* Unable to give valid informed consent
* Known pregnancy or intent to conceive during the study period
* Pacemaker, implantable defibrillator, magnetically active metal fragments, claustrophobia or other contraindication to MRI
* Federal medical center inmates.
* Latex allergy

Primary outcomes:
measure: The values and correlation of f with IF
timeFrame: 2 years
Secondary outcomes:
measure: The correlation of f with renal function attributes and pro-fibrogenic activity
timeFrame: 2 years
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Lilach Lerman, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02860767: Dosing of Antibiotics During Reimplantation of Infected Knee and Hip Prostheses
Official title: Dosing of Antibiotics (Serum and Periprosthetic Tissues) During Reimplantation of Infected Knee and Hip Prostheses
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Prosthesis-Related Infections
Keywords: Prosthesis-Related Infections
Antibiotic dosing
Reimplantation
Knee-prothesis
Hip-prothesis
Lead sponsor: Tourcoing Hospital
Sponsor class: OTHER
First posted: 2016-08-09
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients with hip and knee prostheses infections

Brief summary: The purpose of the study is to evaluate the concentrations of antibiotics used as empirical treatment in serum and periprosthetic tissues during reimplantation of infected hip and knee prostheses

Detailed description: The purpose of the study is to evaluate the concentrations of antibiotics (daptomycin, vancomycin, cefotaxime, ceftriaxone, cefepime) in serum and periprosthetic tissues(bone and synovial joint) used as empirical treatment during reimplantation of infected hip and knee prostheses (1-stage or 2-stage management).

Eligibility criteria: Inclusion Criteria:

* Adult patients (aged of 18 years or more) who undergo reimplantation surgery for infected hip or knee prosthesis (performed in 1 or 2-stage(s)), and for whom referral physicians plans to use an empirical antibiotic therapy including cefotaxime, ceftriaxone, cefepime, daptomycin, or vancomycin.

Exclusion Criteria:

* Patients with multiple prosthetic joint infections, or with curative antibiotic therapy ongoing within two weeks or less prior to surgery, or for whom an antibiotic prophylaxis is decided by referral for the reimplantation surgery, or for whom an antibiotic-loaded cement containing the same antibiotic chosen for empirical therapy after reimplantation was used in case of 2-stage exchange

Primary outcomes:
measure: Primary outcome measure was the evaluation of concentrations in serum and periprosthetic tissues of antibiotic agents used as empirical therapy during reimplantation of the infected prosthesis
timeFrame: 1 day
Secondary outcomes:
measure: Secondary outcome will analyze the ratio of antibiotic concentration in serum and prosthetic tissues to minimum inhibitory concentration of the concerned antibiotic for the pathogen(s) identified in intraoperative samples
timeFrame: 1 day
Other outcomes:
Locations:
city: Amiens
country: France
facility: CHU
city: Caen
country: France
facility: CHU
city: Lille
country: France
facility: CHRU
city: Rouen
country: France
facility: CHU
city: Tourcoing
country: France
facility: Dron Hospital
Study officials:
affiliation: Dron Hospital Tourcoing France
name: Eric M Senneville, MD, PhD
role: STUDY_DIRECTOR
affiliation: Dron Hospital Tourcoing France
name: Sophie Nguyen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06595667: Fluid Responsiveness in Posterior Fossa Tumor Resection: PPV and CVP Guidance
Official title: Fluid Responsiveness Assessment in Adult Neurosurgical Patients Undergoing Posterior Fossa Tumor Resection in the Park Bench Position: a Comparison Between Pulse Pressure Variation (PPV) and Central Venous Pressure (CVP) Guidance
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Posterior Fossa Tumor
Brain Tumor Adult
Keywords: Parkbench position
posterior fossa tumor
pulse pressure variation
fluid responsiveness
Lead sponsor: Chiang Mai University
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Two study groups are parallel according to the block of four randomization.
Primary purpose: TREATMENT

Brief summary: To answer the question: What are the differences in intraoperative fluid administration volumes between PPV and CVP-guided strategies during posterior fossa tumor resection in the park bench position?

Detailed description: Prospective RCT is conducted to compared the amount of fluid volume in adult patients undergoing posterior fossa surgery in park bench position.

Eligibility criteria: Inclusion Criteria:

1. Adult patients aged 18 years and above
2. American Society of Anesthesiologists (ASA) I and II
3. Diagnosis of posterior fossa tumor requiring surgical resection in the park bench position, under general anesthesia at our hospital
4. Willing to participate in the study

Exclusion Criteria:

1. Arrhythmia
2. Significant cardiac diseases
3. Chronic obstructive airway disease
4. Elevated intra-abdominal pressure
5. Tumors prone to precipitate diabetes insipidus
6. Peripheral vascular disease
7. Pulmonary hypertension
8. Patients in sepsis

Primary outcomes:
measure: Total intraoperative fluid administration volumes during surgery
timeFrame: during surgery
Secondary outcomes:
measure: vital signs
timeFrame: during surgery, the data will be recorded every 5 minutes throughout the procedure
measure: vital signs
timeFrame: during the admission in neurosurgical ICU up to 3 days after surgery
measure: time to extubation
timeFrame: 48 hours after surgery at the neurosurgical intensive care unit
Other outcomes:
measure: vasopressor requirement
timeFrame: during surgery and 48 hours at the neurosurgical ICU
measure: length of neurosurgical ICU stay
timeFrame: from date of randomization to the day of being discharged from ICU or up to 1 week after surgery, depended on which happen first
Locations:
city: Chiang Mai
country: Thailand
facility: Chiang Mai University
Study officials:
affiliation: Chiang Mai University
name: Pathomporn P Pin on, Associate Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00347867: Viagra for the Treatment of IUGR
Official title: Improvement of Utero-Placental Perfusion and Fetal Growth in IUGR and PET by Administration of Sildenafil Citrate in Pregnancy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: IUGR
Keywords: IUGR
PET
Pregnancy
Viagra
Sildenafil citrate
Lead sponsor: Rambam Health Care Campus
Sponsor class: OTHER
First posted: 2006-07-04
Enrollment: 20
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: It has been suggested that Viagra (or other drugs that inhibit PDE-5, the enzyme that normally inhibits blood vessels' ability to expand) may have beneficial effects in hypertensive pregnancy and, possibly, preeclampsia.The benefits of Viagra were observed without any reduction in maternal blood pressure, thereby dissociating hypertension per se from the loss of NO (nitrous oxide) signaling in the uterine circulation.Following publications, suggesting that sildenafil citrate used as a therapeutic agent may improve myometrial perfusion in IUGR gestations by promoting myometrial small artery vasodilatation, decreasing peripheral resistance and increasing flow within the uteroplacental bed, we intend to administer this medication to parturients where intauterine growth restriction and pregnancy associated hypertension have been diagnosed in an attempt to induce vasodilatation and improved uteroplacental perfusion resulting in improved fetal growth.

Detailed description: Each participant will receive, after informed consent a 25 mg tablet of Viagra \[sildenafil citrate \]orally. The uteroplacental perfusion will be measured using transvaginal and transabdominal ultrasound Doppler velocimetry studies, before and after 2, 4, and 24 hours of Viagra ingestion. If no significant side effects are recorded, the protocol will be repeated , 48 hours after the first tablet ingestion, but using 50 mg Viagra.In cases of positive and encouraging results and if no serious side effects are detected we shall consider repeated administration of the lowest effcetive dose of viagra in an attempt to prevent prematurity and possibly reach term.our study will evaluate the effects of Viagra on uterine blood flow changes during pregnancy, and possible changes in other systems that contribute to normal fetal growth and development, in parallel to monitoring general and possible deleterious effects on the retina or other possible maternal or fetal organs.

Eligibility criteria: Inclusion Criteria:

* IUGR/PET/Pregnancy weeks 24-33.
* Informed consent.

Exclusion Criteria:

* Maternal cardiovascular morbidity.
* Usage of any vasodilator medication
* Smoking
* Diabetes

Primary outcomes:
measure: Uteroplacental perfusion
measure: Fetal growth
measure: Maternal and fetal safety
Secondary outcomes:
Other outcomes:
Locations:
city: Haifa
country: Israel
facility: RAMBAM Health Care Campus
Study officials:
affiliation: RAMBAM Health Care Campus, Technion
name: Zeev Blumenfeld, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06576167: COVID-19 Self-testing IMPROVE
Official title: Project IMPROVE: Implementing Community-Engaged Intervention Research to Increase Rapid SARS-CoV-2 Self-Testing Among Diverse Underserved and Vulnerable Asian Americans
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COVID-19
Lead sponsor: Temple University
Sponsor class: OTHER
Collaborators: name: National Institute on Minority Health and Health Disparities (NIMHD)
First posted: 2024-08-28
Enrollment: 1271
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SEQUENTIAL
Intervention model description: stepped wedge clustered-randomized trial
Primary purpose: SCREENING

Brief summary: The study aims to engage community partners to implement IMPROVE intervention and promote (COVID-19) rapid testing among vulnerable Asian Americans in the Greater Philadelphia Area and New York City


Eligibility criteria: Inclusion Criteria:

* (1) self-identified as Asian from one of the subgroups: Chinese, Korean, Vietnamese, Filipino, or other South Asian Americans,
* (2) aged 18 and above,
* (3) living in the Greater Philadelphia or NYC areas,

Exclusion Criteria:

-

Primary outcomes:
measure: the change in the rate of COVID-19 self-testing
timeFrame: baseline, 1-month follow up, and 3-month follow up
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Center for Asian Health, Lewis Katz School of Medicine, Temple University
state: Pennsylvania
Study officials:
References:
Clinical trial NCT01109901: Comparison of Effect of Anterior Subcutaneous and Submuscular Transposition on Cubital Tunnel Syndrome
Official title: Study of Surgical Methods for Cubital Tunnel Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Cubital Tunnel Syndrome
Keywords: Cubital tunnel,subcutaneous transposition,submuscular
Lead sponsor: Isfahan University of Medical Sciences
Sponsor class: OTHER
First posted: 2010-04-23
Enrollment: 48
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine which surgical method is better for cubital tunnel syndrome in outcomes.

Detailed description: Compression of the ulnar nerve at the cubital tunnel is the most common cause of numbness on the ulnar side of the hand. We aimed to compare patient outcomes included pain, sensation, muscle strength and muscle atrophy in two methods of surgery contain Anterior Sub Cutaneous Transposition (ASCT) and Anterior Sub Muscular Transposition (ASMT) of the ulnar nerve in Cubital tunnel syndrome.

Eligibility criteria: Inclusion Criteria:

* patients with confirmed cubital tunnel syndrome

Exclusion Criteria:

* Significant cervical spine and shoulder disease
* deformity or distortion of the cubital tunnel due to previous trauma to elbow
* recurrent cubital tunnel syndrome after previous surgery.

Primary outcomes:
measure: Pain
timeFrame: at 6 months post-operatively
Secondary outcomes:
measure: sensation
timeFrame: at 6 months post-operatively
measure: Muscle strength
timeFrame: at 6 months post-operatively
measure: Muscle atrophy
timeFrame: at 6 months post-operatively
Other outcomes:
Locations:
city: Isfahan
country: Iran, Islamic Republic of
facility: Al-zahra university hospital
Study officials:
affiliation: MD,research comittee
name: hamidreza Shemshaki, MD
role: STUDY_CHAIR
References: