louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT07026760: Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals
Official title: Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE1
Conditions: Healthy Individuals
Keywords: Trans-spinal magnetic stimulation
Cortical Excitability
Lead sponsor: Universidade Federal de Pernambuco
Sponsor class: OTHER
First posted: 2025-06-18
Enrollment: 18
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This study investigates the immediate effects of different parameters (frequency and intensity) of trans-spinal magnetic stimulation (TsMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEP), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.

Detailed description: This clinical trial comprises one arm: it evaluates trans-spinal magnetic stimulation (TsMS) applied at the C7 vertebral level, testing three frequencies (1 Hz, 10 Hz, and 25 Hz) and three intensities (90%, 100%, and 110% of the resting motor threshold) across sequential phases.

Methods: The study is a crossover, double-blind trial in which healthy adults (aged 18-40 years) undergo pre- and post-intervention assessments of cortical excitability (MEP, ICI, and ICF). Statistical analyses will be performed using ANOVA or Friedman tests (SPSS v.26).

The results will clarify whether the neuromodulatory effects of the stimulation are parameter-dependent and will guide future rehabilitation protocols for neurological conditions.

The research was approved by the Ethics Committee of the Federal University of Pernambuco (Resolution 466/12). All data will be stored securely for the next five years.

Eligibility criteria: Healthy adults aged 18-40 years, of both sexes; right-handed (confirmed via the Edinburgh Handedness Inventory); and for women, consistent use of contraceptive medication to mitigate hormonal influences on nervous system excitability.

Exclusion Criteria:

Pregnancy; history of seizures or epilepsy; metallic implants in the head, spine, face, or heart; diagnosed neurological or musculoskeletal conditions that could interfere with assessments or interventions; or use of substances that alter nervous system excitability.

Primary outcomes:
measure: Cortical excitability
timeFrame: Baseline (T0), immediately post-stimulation (T1), and at 15 (T2) and 30 minutes (T3) after stimulation.
Secondary outcomes:
Other outcomes:
Locations:
city: Recife
country: Brazil
facility: Universidade Federal de Pernambuco
state: Pernambuco
Study officials:
References:
Clinical trial NCT02645760: Effectiveness of Core Stabilization Exercise in Patients With Subacute Non-Specific Low Back Pain
Official title: Comparison of Core Stabilization Exercise and Physical Therapy Treatment in Patients With Subacute Non-specific Low Back Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Low Back Pain
Lead sponsor: Khon Kaen University
Sponsor class: OTHER
First posted: 2016-01-05
Enrollment: 38
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to examines the effectiveness of Core stabilization exercise on pain intensity at rest, functional disability, lumbar movement and ability to perform repositioning tasks (joint position sense) in patients with subacute non-specific low back pain.

Detailed description: This study is to compare the effectiveness of Core stabilization exercise and physical therapy on pain intensity at rest, functional disability, lumbar movement and ability to perform repositioning tasks (joint position sense) in patients with subacute non-specific low back pain. There are 2 groups receiving 2 different kinds of intervention: treatment group receiving core stabilization exercise (CSE) and control group receiving physical therapy including therapeutic ultrasound and hydrocollator pack. Each intervention will perform for 7 weeks. The patients will assess for all outcome measures at baseline, 7 weeks of intervention, and 1- month follow-up

Eligibility criteria: Inclusion Criteria:

* Onset of back pain within 6 -12 weeks participants had no history of back pain for a period of 6 months prior to the current episode.
* Pain intensity measure by a numerical rating scale (0-10 NRS) and a score of pain at least 3 out of 10.
* Never receive the treatment by core stabilization exercise (CSE) during 3 months before participate in this study.

Exclusion Criteria:

* Pregnancy
* Onset of serious spinal pathology: spinal fracture, spinal tumor or spinal infection.
* Cauda equina syndrome.
* Presented at least 2 out of 3 signs of neurological deficit

Primary outcomes:
measure: Change From Baseline in Pain on 11- Point Numerical Rating Scale at Week 7
timeFrame: baseline an week 7
Secondary outcomes:
measure: Change From Baseline in Functional Disability on Roland-Morris Disability Questionnaire at Week 7
timeFrame: baseline and week 7
measure: Change From Baseline in Back Range of Motion (Flexion) on Modified-modified Schober's Test at Week 7
timeFrame: baseline and week 7
measure: Change From Baseline in Repositioning Error on Repositioning Test at Week 7
timeFrame: baseline and week 7
Other outcomes:
Locations:
city: Muang Khon Kaen
country: Thailand
facility: Faculty of Associated Medical Sciences, Khon Kaen University
state: Khon Kaen
Study officials:
affiliation: Faculty of Associated Medical Sciences, Khon Kaen University
name: Rungthip Chalermsan
role: STUDY_DIRECTOR
References:
Clinical trial NCT03601260: The Percentage of Cases of Acute Treatment With Allopurinol in Gout Patients
Official title: To Examine the Percentage of Cases of Acute Treatment With Allopurinol in Gout Patients as Secondary Treatment
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Gout
Lead sponsor: Hillel Yaffe Medical Center
Sponsor class: OTHER_GOV
First posted: 2018-07-26
Enrollment: 700
Sex: ALL
Minimum age (years): 25
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The aim of the study is to determine the percentage of cases of acute treatment with Allopurinol in gout patients who have been previously treated.


Eligibility criteria: Inclusion Criteria:

* Gout patients

Exclusion Criteria:

* Pregnant women
* Chronic renal failure
* Patients with Allopurinal hypersensitivity

Primary outcomes:
measure: Gout patients treated with Allopurinol
timeFrame: Six months
Secondary outcomes:
measure: Patients with contraindication to Allopurinol
timeFrame: Six months
Other outcomes:
Locations:
city: Hadera
country: Israel
facility: Hillel Yaffe Medical Center
Study officials:
References:
Clinical trial NCT04494360: Study to Estimate How Common it is to Have Genetic Variants Associated With NAFLD
Official title: Study for the Identification of Participants With Liver Steatosis Who Carry Genetic Variants Associated With Nonalcoholic Fatty Liver Disease (NAFLD)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Lead sponsor: Janssen Research & Development, LLC
Sponsor class: INDUSTRY
First posted: 2020-07-31
Enrollment: 830
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants, who are known to have, or are likely to have, NAFLD.

Brief summary: The purpose of this study is to estimate the prevalence of genetic variants associated with liver disease in participants who are known, or are likely to have NAFLD.


Eligibility criteria: Inclusion Criteria:

* No clinically significant abnormality based on medical history, physical exam, and 12-lead electrocardiogram (ECG) collected during Visit 1
* Women must be of non-childbearing potential, defined as either: a.) Postmenopausal or b.) Permanently sterile
* Must be willing to provide a deoxyribonucleic acid (DNA) sample for assessment of genetic variants associated with NAFLD
* Must sign an informed consent form (ICF) indicating that he or she understands the purpose of, and procedures required for, the study and is willing to participate in the study

Exclusion Criteria:

* History or presence of drug abuse within the 2 years prior to Visit 1
* Excessive use of alcohol within 2 years prior to the study
* Body mass index greater than (\>) 40 kilogram per meter square (kg/m\^2)
* Evidence of other active (acute or chronic) liver disease other than NAFLD/ Nonalcoholic steatohepatitis (NASH)
* History of bariatric surgery or planning to undergo bariatric surgery within the next year
* Inability to undergo magnetic resonance imaging (MRI)

Primary outcomes:
measure: Prevalence of Genetic Variants Associated with NAFLD
timeFrame: Up to 8 weeks
measure: Liver Fat Content Estimated with Fibroscan
timeFrame: Up to 8 weeks
Secondary outcomes:
measure: Liver Fibrosis Estimated with Fibroscan
timeFrame: Up to 8 weeks
measure: Hepatic Fat Fraction
timeFrame: Up to 8 weeks
Other outcomes:
Locations:
city: Hollywood
country: United States
facility: Research Centers of America, LLC
state: Florida
city: Lenexa
country: United States
facility: PRA Health Sciences
state: Kansas
city: San Antonio
country: United States
facility: Endeavor Clinical Trials, LLC
state: Texas
Study officials:
affiliation: Janssen Research & Development, LLC
name: Janssen Research & Development, LLC Clinical Trial
role: STUDY_DIRECTOR
References:
Clinical trial NCT05945160: Vestibular Function Using Mitochondrial Antioxidant Therapy
Official title: A Randomized Controlled Study Using Alpha Lipoic Acid and CoQ-10 to Determine if Vestibular Function Can be Improved or Maintained Over the Course of One Year
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: EARLY_PHASE1
Conditions: Vestibular Function Disorder
Keywords: Alpha lipoic acid
CoQ10
Lead sponsor: The University of Texas Health Science Center at San Antonio
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
First posted: 2023-07-14
Enrollment: 0
Sex: ALL
Minimum age (years): 65
Maximum age (years): 90
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Two arm non-blinded controlled clinical trial. Subjects will be randomized 1: 1 either into the investigational antioxidant arm or the standard of care, no study drug arm.
Primary purpose: TREATMENT

Brief summary: To determine if supplementation with known mitochondrial antioxidants (alpha lipoic acid (ALA) and CoQ-10) will stabilize or improve vestibular function in older adults.

Detailed description: The subjects will be divided into two groups, half will be given daily supplementation with ALA and CoQ-10. The second group will only receive standard of care treatment, with no study drug intervention.

Eligibility criteria: Inclusion Criteria:

1. Community dwelling non-gender specific aged 65-90 years of age
2. For female subjects, confirm that they are post-menopausal
3. Diagnosed with vestibular dysfunction
4. Able to provide informed consent
5. Prepared to adhere to study drug regimen and attend all study visits

Exclusion Criteria:

1. Unable to provide informed consent
2. Allergy/sensitivity to the study drugs or any of their ingredients
3. Unable to adhere to study drug regimen or to attend study visits.
4. Current or past participation within a specified timeframe in another clinical trial, as warranted by the administration of this intervention.
5. Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.
6. Anticoagulant drugs: Anisindione (Miradon), dicumarol and warfarin (Coumadin and Jantoven)
7. Participants who are currently undergoing treatment with Insulin, Levothyroxine or chemotherapy drugs.
8. Participants who are undergoing treatment with theophylline.

Primary outcomes:
measure: Slow Harmonic Acceleration
timeFrame: Baseline to 12 months
Secondary outcomes:
measure: Step Velocity Test
timeFrame: Baseline to 12 months
measure: Number of falls
timeFrame: Baseline to 12 months
measure: Tolerance of supplements
timeFrame: Baseline to 12 months
Other outcomes:
Locations:
city: San Antonio
country: United States
facility: University of Texas Health Science Center at San Antonio
state: Texas
Study officials:
affiliation: University of Texas Health Science Center San Antonio
name: Brian Perry, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04156360: Construction and Evaluation of the Liquid Biopsy-based Early Diagnostic Model for Lung Cancer
Official title: Construction and Evaluation of the Liquid Biopsy-based Early Diagnostic Model for Lung Cancer
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Healthy
Pulmonary Nodule
Lead sponsor: Shanghai Pulmonary Hospital, Shanghai, China
Sponsor class: OTHER
First posted: 2019-11-07
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects with pulmonary nodules diagnosed by chest CT or low-dose computed tomography (LDCT) scans

Brief summary: The purpose of this study is to detetct Circulating tumor cells(CTCs) and Cancer Associated Macrophage-Like cells (CAMLs) in patients with pulmonary nodules using a novel microfluidic CTC-detection system. Then construct an early diagnostic model for lung cancer.

Detailed description: Patients found pulmonary nodules by CT screening will be enrolled in this study prospectively. CTCs and CAMLs both are cancer specific biomarkers found in the peripheral blood of patients with solid tumors including lung cancer. Through detecting CTCs and CAMLs in healthy volunteers and patients with pulmonary nodules who undergo biopsy, determine the cut-off value of the test. Further analysis of the test specificity and sensitivity, and on this basis construct an early diagnostic model for lung cancer.

Eligibility criteria: Inclusion Criteria:

* Female or male, 18 years of age or older
* Pulmonary nodules diagnosed by chest CT or low-dose computed tomography (LDCT) scans

Exclusion Criteria:

* Prior diagnosis of lung cancer or other invasive malignancy within the past 5 years

Primary outcomes:
measure: Determination of prevalence of CTCs and CAMLs in patients with pulmonary nodules
timeFrame: 12 months
Secondary outcomes:
measure: Determination of optimal cut-off values for screening Lung Cancer paitents
timeFrame: 6 months
Other outcomes:
Locations:
Study officials:
affiliation: Shanghai Pulmonary Hospital, Tongji University
name: Yayi He, MD, PHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05318560: Efficacy of Local Anesthetic and Ozone Injection in Patients With Myofascial Pain Syndrome
Official title: Comparison of the Efficacy of Local Anesthetic and Ozone Injection in Patients With Myofascial Pain Syndrome
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Myofascial Pain Syndrome
Ozone
Keywords: Ozone
Pain
Lead sponsor: Pamukkale University
Sponsor class: OTHER
First posted: 2022-04-08
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study, the investigators planned to compare local anesthetic injection added to stretching exercise, ozone injection treatment added to stretching exercise, and only stretching exercise in patients with upper trapezius muscle myofascial pain syndrome.

Detailed description: The investigators will recruit 72 patients with at least one trigger point in the upper trapezius muscles and a clinically confirmed diagnosis of myofascial pain syndrome (MAS) (according to Travell-Simons' criteria) admitted to the physical medicine and rehabilitation outpatient clinic.

Age, gender, occupation, medications, duration of diagnosis, body mass index, comorbidity, functional status and pain of these patients will be questioned. Patients will be randomly divided into three groups. A total of 3 consecutive weeks of treatment were planned.

Eligibility criteria: Inclusion Criteria:

* With at least one trigger point in the upper trapezius muscles and a clinically confirmed diagnosis of MPS

Exclusion Criteria:

* Presence of any cervical radiculopathy or a history of degenerative conditions
* Presence of any cervical surgery or trauma in the past year,
* History of injection for the treatment of MAS in the last 6 months,
* Cognitive disorder,
* Rheumatological disease, fibromyalgia,
* History of metabolic diseases such as hypothyroidism and diabetes mellitus

Primary outcomes:
measure: Visual Analogue Scale (VAS)
timeFrame: Change from baseline VAS at the 1st week after the treatment.
Secondary outcomes:
measure: Neck Disability Index (NDI)
timeFrame: Change from baseline VAS at the 1st week after the treatment.
measure: Range of motion (ROM)
timeFrame: Change from baseline VAS at the 1st week after the treatment.
Other outcomes:
Locations:
Study officials:
affiliation: Pamukkale University
name: Hakan Alkan, Prof.
role: STUDY_DIRECTOR
References:
Clinical trial NCT01522560: Evaluation of Multiscore Feedback in Professionalism for Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: CA2 and CA3 Residents Doing a Two Month Rotation in
Pediatric Anesthesia Department
Keywords: CA2 and CA3 residents
Pediatric Anesthesia
Lead sponsor: The Cleveland Clinic
Sponsor class: OTHER
First posted: 2012-01-31
Enrollment: 28
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Professionalism is one of the six competences required by The Accreditation for Graduate Medical Education Outcome Project to be taught and evaluated during residency. Anesthesia residents are faced with unique communication challenges in their practice including brief contact time with their patients, operating room efficiency pressure, etc. To assess professionalism in Anesthesiology residents is important to obtain evaluations from people with whom they interact including patients, surgeons, colleagues and members of the support team. The Multisource feedback (MSF) approach has been used to evaluate communication skills and professionalism among practicing physicians and residents in a variety of settings. This evaluation model has never been used previously to evaluate anesthesia residents. The investigators propose a randomized controlled trial to validate and evaluate a MSF in professionalism for anesthesia residents. Participants include eighty residents doing two months rotation in Pediatric Anesthesia Department at The Cleveland Clinic Anesthesia Institute from July 1, 2011 and June 30, 2013. MSF questionnaires will be validated using face and content validity methods and comparing them with the current system of evaluation. Residents will be randomly assigned to a feedback group or to the control group. Both groups will receive MSF evaluation from the faculty, patients' parent and coworker. Only the group assigned to feedback is going to have a 'coaching meeting' every month to identify strengths and weaknesses and create strategies for improvement. The investigators are planning to compare the mean values of the baseline evaluations with the mean values obtained after the first and second months from the MSF.


Eligibility criteria: Inclusion Criteria:

* CA2 and CA3 residents doing a two month rotation in Pediatric Anesthesia Department

Exclusion Criteria:

* N/A

Primary outcomes:
measure: Validate Multiscore Feedback (MSF)
timeFrame: up to 60 days
Secondary outcomes:
measure: secondary goal is to test a Multiscore Feedback (MSF) as a method of evaluation in professionalism for anesthesia residents.
timeFrame: up to 18 months
Other outcomes:
Locations:
city: Cleveland
country: United States
facility: Cleveland Clinic Foundation
state: Ohio
Study officials:
affiliation: The Cleveland Clinic
name: Nelson Riveros, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02518360: Osteopathic Treatment in Patients With Low Back Pain: Stabilometry
Official title: Effect of Osteopathic Treatment in Patients With Nonspecific Low Back Pain: Stabilometry
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lower Back Pain
Keywords: NON SPECIFIC LOW BACK PAIN
OSTEOPATHY
FOOT PRESSURE PLATFORM
POSTURAL BALANCE
Lead sponsor: Universidad Miguel Hernandez de Elche
Sponsor class: OTHER
First posted: 2015-08-07
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Determine the improvement in nonspecific low back pain patients with osteopathic techniques (Body Adjustment Protocol) and know changes in stabilometric measures analyzed with a stabilometric platform (Footscan®).

Detailed description: Fifty patients participate in this study (25 experimental group with body adjustment protocol of osteopathy and 25 control group). For a first objective of this study, all the patients determine if the osteopathic approach to the body adjustment approach will improve low back pain (Oswestry Questionnaire). For the second aim, the investigators want to know if there are changes in the distribution of body weight in lower limbs in group experimental and control group, analyzed with a stabilometric platform (Footscan®).

The experimental group is treated with osteopathy, three sessions (20 minutes/session) and a frequency one session/week. The treatment osteopathic is the body adjustment protocol. In the other hand, the control group made 2 stretching global postures once a week (10 minutes for each posture) for three weeks: the first was for the anterior muscular chain and the second posture to stretch the posterior muscle chain. Before treatment, immediately after the last session and a month later, are measured stabilometric parameters, height and Oswestry.

The analysis will be made with Statistical Package for the Social Sciences (SPSS Statistics) 22.0

Eligibility criteria: Inclusion Criteria:

* Aged between 18 and 65 years.
* Patients with non-specific low back pain.
* Patients with alteration in the distribution of loads in a podiatric platform.

Exclusion Criteria:

* Specific low back pain diagnosed.
* Pregnancy.
* Recent surgery in the last year.
* Acute musculoskeletal disorders out of the lumbar region.
* Patients with vestibular and instability problems.
* Meniere syndrome.
* Oncologic patients.
* Patients with manual therapy treatment during the study.

Primary outcomes:
measure: Oswestry Questionnaire
timeFrame: 5 minutes
Secondary outcomes:
measure: Centre of Pressure Displacement
timeFrame: 5 minutes
Other outcomes:
Locations:
Study officials:
References: