Clinical trial NCT06478303: LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension
Official title: LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Corticospinal Excitability
Cortical Activation
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
Collaborators: name: University of Burgundy
First posted: 2024-06-27
Enrollment: 105
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects will be aged between 18 and 40, reading and understanding French, with no neurological or psychiatric disorders, no uncorrected vision deficits, and meeting all MRI or TMS examination criteria. they were recruited at the University of Burgundy (TMS measures only) and the University of Grenoble Alpes (fMRI measures only).

Brief summary: Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research. An illustrative example is the interaction between language comprehension and motor representations. For instance, motor training (e.g., sports, origami training) can facilitate action verb recognition, whereas motor deficits (e.g., upper limb immobilization) can hinder the processing of action language. Similarly, action language has been shown to affect motor performance. These effects are attributed to an implicit form of motor imagery, an automatic simulation of motor experience (without actual movement) evoked by action words. Interestingly, literature supports the idea that the motor simulations used for imagining an action are also engaged during the reading of action language, leading to similar neurophysiological and behavioral changes in both processes. However, questions remain about the similarity of the simulations generated by motor imagery and action language. This project, encompassing three experimental sequences, aims to address these questions to achieve significant scientific advancements in both theoretical and applied domains.


Eligibility criteria: Inclusion Criteria:

* persons who have given written consent,
* healthy subjects
* subjects reading and understanding French
* right-handed,
* affiliated with a social security system,
* between 18 and 40 years old,
* had completed the TMS inclusion questionnaire or had undergone a medical examination prior to participation in the MRI study.

Exclusion Criteria:

* Existence of a severe general medical condition: cardiac, respiratory, hematological, renal, hepatic, cancerous,
* Regular use of anxiolytics, sedatives, antidepressants, neuroleptics,
* Characterized psychiatric pathology,
* Ingestion of alcohol prior to the examination,
* Persons covered by articles L1121-5 to L1121-8 of the CSP,
* Presence of contraindications to MRI or TMS.

Primary outcomes:
measure: Level of corticospinal excitability
timeFrame: 1 hour and 30 minutes
measure: Cortical activation (BOLD signal)
timeFrame: 1 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Grenoble
country: France
facility: CHU Grenoble Alpes
state: Grenob
city: Dijon
country: France
facility: Université de Bourgogne
Study officials:
affiliation: CHU Grenoble Alpes
name: Laurent VERCUEIL
role: PRINCIPAL_INVESTIGATOR
References: