Clinical trial NCT05450757: Shanghai ST-segment Elevation Myocardial Infarction Cohort
Official title: A Prospective Multicentre Cohort Study of Acute ST-segment Elevation Myocardial Infarction
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: ST Elevation Myocardial Infarction
Keywords: Acute Myocardial Infarction
Cardiac Remodelling
Heart Failure
Lead sponsor: Ruijin Hospital
Sponsor class: OTHER
First posted: 2022-07-11
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: This is multi-center cohort study. Patients with acute ST elevation myocardial infarction undergo percutaneous coronary intervention within 12 hours of symptom onset at Ruijin Hospital, Minhang district Center Hospital, Yangpu district Center Hospital, Putuo district Center hospital,Jiading district Center Hospital, Fengxian district Center Hospital,and Shanghai Fifth people's Hospital, Shanghai, China are consecutively enrolled.

Brief summary: ST-segment elevation myocardial infarction(STEMI) remains a major cause of morbidity and mortality worldwide, despite of the early reperfusion therapy, including fibrinolysis, primary percutaneous coronary intervention (PCI),and standardized medical treatment.To improve the prognosis of STEMI patients, the management in their hospitalization should be optimized, including improvements in risk stratification, more widespread use of an invasive strategy, implementation of care delivery systems prioritising immediate revascularisation through PCI (or fibrinolysis), advances in antiplatelet agents and anticoagulants, and greater use of secondary prevention strategies such as lipid-lowering therapy.

This study aims to standardized the management of STEMI patients and improve the prognosis of the STEMI patients.

Detailed description: This study is a prospective cohort study. It aims to standardized the management of STEMI patients and improve the prognosis of the STEMI patients.

Eligibility criteria: Inclusion Criteria:

* ST elevation myocardial infarction
* Coronary angiography and percutaneous coronary intervention within 12 hours of symptom onset
* Capable and willing to provide informed conset and capable of completing study visits

Exclusion Criteria:

* Cardiovascular shock at admission
* Severe physical disability
* Active malignant tumors
* Active autoimmune diseases

Primary outcomes:
measure: MACE
timeFrame: 0-1 year
measure: Left Ventricular Function
timeFrame: 1 month, 6month and 1 year
measure: Coronary angiography
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
measure: Synchronized analysis of phonocardiogram and electrocardiogram
timeFrame: 1 day, 1 month, 6 months, 1 year
Locations:
city: Shanghai
country: China
facility: Ruijin hospital, Shanghai Jiaotong University School of Medicine
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Fengxian District Central Hospital
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Fifth People's Hospital, Fudan University
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Jiading District Central Hospital
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Minhang District Central Hospital
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Putuo District Central Hospital
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Yangpu District Central Hospital
state: Shanghai
Study officials:
affiliation: Ruijin Hospital
name: Wei Wei Quan, M.D.,Ph.D.
role: STUDY_CHAIR
affiliation: Ruijin Hospital
name: Tian Qi Zhu, M.D.,Ph.D.
role: STUDY_CHAIR
affiliation: Ruijin Hospital
name: Xiao Xiang Yan, M.D.,Ph.D.
role: STUDY_CHAIR
affiliation: Ruijin Hospital
name: Wen Li Zhang, M.D.,Ph.D.
role: STUDY_CHAIR
affiliation: Ruijin Hospital
name: Run Du, M.D.,Ph.D.
role: STUDY_CHAIR
affiliation: Fudan University
name: Ying Jia Xu, M.D.,Ph.D.
role: STUDY_CHAIR
affiliation: Shanghai Minhang District Central Hospital
name: Wei Hu
role: STUDY_CHAIR
affiliation: Tongji University
name: Yimeng Zhou
role: STUDY_CHAIR
affiliation: Shanghai Putuo District Central Hospital
name: Zongjun Liu
role: STUDY_CHAIR
affiliation: Shanghai Jiading District Central Hospital
name: Xiangdong Xu
role: STUDY_CHAIR
affiliation: Shanghai Fengxian District Central Hospital
name: Zengyong Qiao
role: STUDY_CHAIR
References: