Clinical trial NCT03094962: Development of a Musculoskeletal Model of the PIP Joint
Official title: Development of Parametric Musculoskeletal Models to Investigate the Anatomy and the Function of the PIP
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Patient Specific Computational Modeling
Keywords: Kinematics
MRI Scans
CT Scan, Single-Photon Emission
finger interphalangeal joint
Lead sponsor: University of Southampton
Sponsor class: OTHER
First posted: 2017-03-29
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The proximal interphalangeal (PIP) joint is the second joint in the finger from the finger tip. The outcome following replacement surgery of this joint is considered unsatisfactory. In order to improve these outcomes, it would be helpful to understand the geometry of the joint, how it moves and the forces that are involved. This can be achieved using computer models that model the bones and the soft tissues - musculoskeletal models. In order to make these models as representative as possible, they should be generated using anatomical data.

Data will initially be extracted from patients' existing magnetic resonance imaging (MRI) and computed tomography (CT) scans. This will enable the computer model to begin being constructed. In parallel to the model initialisation, anatomical and motion data of the PIP joint of healthy volunteers will be collected. The necessary data will be collected using CT and MRI scans, as well as optical motion tracking methods. These data will then be used to populate the musculoskeletal model.

Once the model is constructed, it will be used to simulate the motion of the joint and look at the effect of a simulated PIP joint replacement. This information should then provide insight as to how PIP joint replacements might be improved in future.


Eligibility criteria: Inclusion Criteria:

* In general good health
* University of Southampton members of staff
* Over 18 years old and able to provide informed consent
* No known problems relating to the PIP joint

Exclusion Criteria:

* Volunteers involved in other studies concerned with the function and anatomy of the PIP joint which would have adverse effects on this study and/or the study in which they are currently involved.
* Those undergoing treatment related to the PIP joint
* No metallic object should be present in the scanner and therefore those with any implanted metallic devices, or other devices which may cause or be caused adverse effects (e.g. metal plate, pacemaker)

Primary outcomes:
measure: Capturing hand kinematics using Vicon optical motion capture
timeFrame: 3 years
measure: Capturing images of the soft tissue in the hand using MR imaging
timeFrame: 3 years
measure: Capturing images of the bony structures in the hand using CT scanning
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Southampton
country: United Kingdom
facility: University Hospital Southampton
state: Hampshire
Study officials:
affiliation: University of Southampton
name: Christopher WG Phillips, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Adams J, Ryall C, Pandyan A, Metcalf C, Stokes M, Bradley S, Warwick DJ. Proximal interphalangeal joint replacement in patients with arthritis of the hand: a meta-analysis. J Bone Joint Surg Br. 2012 Oct;94(10):1305-12. doi: 10.1302/0301-620X.94B10.29035.