Clinical trial NCT00664157: Facial Expression Recognition of Emotion and Categorization of Emotional Words in Parkinson's Disease. Impact of L-Dopa and Deep Brain Stimulation of Subthalamic Nucleus
Official title: Facial Expression Recognition of Emotion and Categorization of Emotional Words in Parkinson's Disease. Impact of L-Dopa and Deep Brain Stimulation of Subthalamic Nucleus .
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Idiopathic Parkinson's Disease
Keywords: Idiopathic Parkinson's disease
L-Dopa
Deep Brain stimulation
Facial expression recognition of emotion
Frequency levels
Automatic and voluntary information treatment
Patient with an Idiopathic Parkinson's disease
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
First posted: 2008-04-22
Enrollment: 80
Sex: ALL
Minimum age (years): 30
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: DIAGNOSTIC

Brief summary: Parkinson'disease is a neurodegenerative disorder characterised by bradykinesia, rigidity, rest tremor and postural instability. Dopaminergic therapy such as L-Dopa and dopamine agonists usually leads to a dramatic improvement of symptoms, but disease progression nevertheless remains inevitable. Bilateral Deep brain stimulation in subthalamic nucleus is now considered the gold standard surgical treatment.

Parkinson'disease mainly affects the nigrostriatal dopaminergic system which is linked to the limbic system and could be responsible of a specific trouble in the recognition in some facial expression.

We hypothesise that patients with Parkinson'disease present a dysfunction of voluntary and automatic treatment of emotional information.

The main purpose of this study is to show if patients with Parkinson'disease present a lack of specific facial expression recognition of emotion and determinate more precisely if this alteration involves the cortical way (high frequency way) or the under cortical way (low frequency way).

We also examine the role of L-Dopa and the deep brain stimulation on emotion perception

Detailed description: 40 patients with an Idiopathic Parkinson's disease divided in two groups :

* 20 patients evaluated before surgery and 6 month after surgery
* 20 patients only evaluated after surgery.

  40 paired healthy volunteers

  1) Study progress (patients):

Inclusion visit :

Neurological evaluations .

Neuropsychological evaluations : MMS, MADRS, MATTIS, BREF, Wisconsin test, Apathy test, Benton....

Ophthalmic visit : VISTECH

Protocol :

1. for patients evaluated before surgery Facial expression recognition test Lexical decision test Made in two conditions : without the treatment (Med OFF) and one hour after the L-Dopa administration (MED ON)
2. for patients evaluated after surgery Facial expression recognition test Lexical decision test Made in four conditions

   * Without stimulation (STIM OFF) and medication (MED OFF)
   * MED OFF and STIM ON
   * MED ON and STIM OFF
   * MED ON and STIM ON

     2) Study progress (healthy volunteers): Ophthalmic visit MMS Facial expression recognition test Lexical decision test

Eligibility criteria: Inclusion Criteria:

* Age : 30-75 years
* Patient with an idiopathic Parkinson's disease according to the criteria of the "Parkinson's Disease Society Brain Bank" (Hughes et al., 1992)
* Patient treated with a deep brain stimulation according to the French consensus conference of treatment of Parkinson's disease (Consensus Conference Proceeding, 2000)
* Effect of the stimulation 50%
* Affiliation to social security
* Agreement of patients

Exclusion Criteria:

* Patients suffering of an atypical Parkinson syndrome
* Patients with severe tremor before surgery
* Patients with a vision contrast altered.
* Patients who do not understand the words associated with an emotion
* Pregnant women
* Person who participate to an other study

Primary outcomes:
measure: Facial expression recognition test
timeFrame: % of exact responses
Secondary outcomes:
measure: Lexical decision test
timeFrame: The time to respond
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU
Study officials:
affiliation: University Hospital, Clermont-Ferrand
name: Franck Durif, PUPH
role: PRINCIPAL_INVESTIGATOR
References: