Clinical trial NCT01684280: Obesity-related Genes in Taiwanese Undergoing Weight Loss
Official title: Searching for the Most Influential Obesity-related Diabetic Genes and Exploring the Expression Profiles of Those Genes in Taiwanese Undergoing Weight Loss
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Morbid Obesity
Keywords: abdominal adipose tissue; microRNA
Lead sponsor: Taipei Medical University Hospital
Sponsor class: OTHER
Collaborators: name: National Science and Technology Council, Taiwan
First posted: 2012-09-12
Enrollment: 20
Sex: ALL
Minimum age (years): 19
Maximum age (years): 63
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men (n = 9) and women (n =10) who underwent bariatric surgery. Their BMI were all over 40 kg/ m2, and ages between 19-63 years.

Brief summary: To investigate:

1. Associations between miRNA and insulin signaling-related gene expressions in abdominal adipose tissues in obese subjects.
2. Differences in miRNAs expressed by intrabdominal omental adipose tissues between genders.

Detailed description: Compared the differences in microRNA expressions of abdominal adipose tissue in morbid obese male and female subjects to elucidate the possible regulatory role of microRNA in insulin signaling-related gene expression levels and its association with biochemical markers. We hope to find a miRNA that can be used to predict the syndrome associated with obesity.

Eligibility criteria: Inclusion Criteria:

* Morbid obesity,BMIs\> 40 kg/m2
* Subjects who underwent bariatric surgery

Exclusion Criteria:

* Obese subjects with complicated metabolic disorders
* Thyroid disease

Primary outcomes:
measure: MicroRNA expression in abdominal omental adipose tissues
timeFrame: up to 28 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Medical University Hospital
Study officials:
affiliation: Comprehensive Weight Management Center Taipei Medical University Hospital
name: Wang Weu
role: STUDY_DIRECTOR
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