Clinical trial NCT03810404: Acute Sodium Bicarbonate Supplementation in Athletes
Official title: The Effect of Acute Sodium Bicarbonate Supplementation on Buffering Potential Kinetics, Physical Capacity and Discipline-Specific Performance
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Supplementation
Sport
Keywords: Sports nutrition
Sodium bicarbonate
Physical capacity
Exercise performance
Buffering potential
Biochemical markers
Lead sponsor: Poznan University of Physical Education
Sponsor class: OTHER
First posted: 2019-01-18
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to verify the effect of acute sodium bicarbonate (SB) and placebo (PLA) supplementation on buffering potential kinetics, physical capacity, discipline-specific performance as well as concentration of diagnostically significant blood biochemical indices in athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Detailed description: Effective muscle work is conditioned by maintaining the proper range of muscles pH, regulated by buffering systems, in which the main role is played by bicarbonates (HCO3-). For this reason, sodium bicarbonate (SB) is often proposed as an ergogenic agent, especially during high-intensity efforts. Until now the major limitation to SB supplementation has been the gastrointestinal (GI) side effects. There is also a lack of data of the individual SB-induced changes of buffering potential kinetics and its actual connection with physical capacity and discipline-specific performance. Therefore, this study aims to examine the effect of acute, different-dose SB ingestion on buffering potential kinetics, physical capacity, discipline-specific performance as well as changes of diagnostically significant blood biochemical indices concentration in athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Eligibility criteria: Inclusion Criteria:

* written consent to participate,
* a current medical clearance to practice sports,
* training experience: at least 2 years,
* minimum of 4 workout sessions (in the discipline covered by the study) a week.

Exclusion Criteria:

* current injury,
* any health-related contraindication,
* declared general feeling of being unwell,
* unwilling to follow the study protocol.

Primary outcomes:
measure: Changes in anaerobic capacity after sodium bicarbonate supplementation and placebo treatment
timeFrame: Baseline and during 1 day of acute SB and PLA supplementation
measure: Changes in discipline-specific exercise capacity after sodium bicarbonate supplementation and placebo treatment
timeFrame: Baseline and during 1 day of acute SB and PLA supplementation
measure: Changes of bicarbonate concentration in blood after sodium bicarbonate supplementation and placebo treatment
timeFrame: Baseline and during 1 day of acute SB and PLA supplementation
measure: Changes of base excess concentration in blood after sodium bicarbonate supplementation and placebo treatment
timeFrame: Baseline and during 1 day of acute SB and PLA supplementation
Secondary outcomes:
measure: Changes of pH in blood after sodium bicarbonate supplementation and placebo treatment
timeFrame: Baseline and during 1 day of acute SB and PLA supplementation
measure: Changes of lactate concentration in blood after sodium bicarbonate supplementation and placebo treatment
timeFrame: Baseline and during 1 day of acute SB and PLA supplementation
measure: Changes of pyruvate concentration in blood after sodium bicarbonate supplementation and placebo treatment
timeFrame: Baseline and during 1 day of acute SB and PLA supplementation
measure: Changes in blood glucose concentration after sodium bicarbonate supplementation and placebo treatment
timeFrame: Baseline and during 1 day of acute SB and PLA supplementation
measure: Changes in hemoglobin concentration after sodium bicarbonate supplementation and placebo treatment
timeFrame: Baseline and during 1 day of acute SB and PLA supplementation
measure: Changes of blood cells concentration in blood after sodium bicarbonate supplementation and placebo treatment
timeFrame: Baseline and during 1 day of acute SB and PLA supplementation
measure: Changes of creatine kinase activity in blood after sodium bicarbonate supplementation and placebo treatment
timeFrame: Baseline and during 1 day of acute SB and PLA supplementation
measure: Changes of lactate dehydrogenase activity in blood after sodium bicarbonate supplementation and placebo treatment
timeFrame: Baseline and during 1 day of acute SB and PLA supplementation
Other outcomes:
Locations:
city: Poznań
country: Poland
facility: Department of Sports Dietetics, Poznan University of Physical Education
Study officials:
affiliation: Department of Sports Dietetics, Poznan University of Physical Education
name: Krzysztof Durkalec-Michalski, Prof., PhD
role: PRINCIPAL_INVESTIGATOR
References: