Clinical trial NCT03653494: the Clinicaltrail of the Effection Which of Phrenic Block Using in Non-intubated Video-assisted Thoracoscopic Surgery
Official title: Department of Anesthesiology in Shenzhen People's Hospital
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: EARLY_PHASE1
Conditions: Phrenic Nerve Paralysis
Keywords: non-intubated general anaesthesia
video-assisted thoracoscopic surgery
phrenic block
Lead sponsor: Shenzhen People's Hospital
Sponsor class: OTHER
First posted: 2018-08-31
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 1. Put 80 patients divided into group S（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia and Vagus block） and group D（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia、Vagus block and Phrenic block）randomly.
2. Compare the volume of anesthetic drugs between the two groups.
3. If the date of group S greater than group D，it shows that the effect of anesthetic effect of group D is better than group S.
Primary purpose: TREATMENT

Brief summary: Putting 80 patients divided into group S（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia and Vagus block） and group D（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia、Vagus block and Phrenic block）randomly,compare the volume of anesthetic and the number of increasing anesthetic during operation were compared between the two groups.If the date of group S greater than group D，it shows that the effect of anesthetic effect of group D is better than group S.

Detailed description: 1. Put 80 patients divided into group S（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia and Vagus block） and group D（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia、Vagus block and Phrenic block）randomly.
2. Compare the volume of anesthetic drugs between the two groups.
3. If the date of group S greater than group D，it shows that the effect of anesthetic effect of group D is better than group S.

Eligibility criteria: Inclusion Criteria:

* The patient agreed to perform non-intubated video-assisted thoracoscopic surgery, and informed the possibility of intraoperative tracheal intubation or thoracotomy.
* No conventional anesthesia contraindication, no history of thoracic surgery, good cardiopulmonary function.
* There is no severe adhesion and calcification in the thoracic cavity, and no artificial pneumothorax is affected.
* the patient has no serious anxiety or depression.
* Small surgical trauma, simple steps, short time.

Exclusion Criteria:

* Mallampati≥3.
* BMI≥26 kg/m2.
* Hemodynamic instability.
* INR≥1.5.
* Respiratory infection, persistent cough or airway mucus hypersecretion, high risk of reflux.
* nervous system disease,such as seizure or brain edema.
* Extensive pleural adhesions or once chest surgery.
* PaO2\<60mmHg or PaCO2\>50 mmHg.
* Central hypopnea syndrome.
* Lung isolation should be used to protect the healthy side of the lung.
* Complicated operation, large trauma, long time, lack of experience or poor cooperation in the surgical team.
* Contraindications to local anesthetic.

Primary outcomes:
measure: the volume of anesthetic drugs
timeFrame: the time of operation， an average of 4 hours
Secondary outcomes:
measure: the time to get out of bed after surgery
timeFrame: two days after surgery
measure: the cost of hospitalization
timeFrame: the time of hospitalization， an average of 7 days
Other outcomes:
Locations:
city: Shenzhen
country: China
facility: Shenzhen People's Hospital
state: Guangdong
Study officials:
affiliation: Shenzhen People's Hospital
name: Dai Z Liang, Doctor
role: STUDY_CHAIR
References: