louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05775926: The Effect of Training Given to Nurses Caring for Dying Cancer Patients and Their Families on Care and Difficulties
Official title: The Effect of Training Given to Nurses Caring for Dying Cancer Patients and Their Families on Care and Difficulties
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dying Patient
Nursing Caries
Keywords: Nursing care
Dying patient
Cancer
Lead sponsor: Cukurova University
Sponsor class: OTHER
First posted: 2023-03-20
Enrollment: 52
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Nursing is a profession that is human and is based on nursing care. Humans are social creatures that need care from the moment they are born.Today's scientific developments and changing technology have affected the health system.Many dying patients want to be hospitalized in order to receive better care and treatment. Depending on this situation, the frequency of nurses giving care to dying patients and their families has increased in hospitals. In order to increase the quality of the care given to the dying patient and his family and to reduce the difficulties experienced while giving this care, the nurse who provides the care should have sufficient knowledge and skills about the care of the dying patient and his family.

This research will be conducted as a randomized controlled experimental study in order to determine the effect of education on the nursing care given and the difficulties experienced by the nurses who care for the dying cancer patients and their families.

Detailed description: The research was carried out to determine the effect of the training given to the nurses who care for the dying cancer patients and their families, on the nursing care and the difficulties experienced.

H1: There is a significant difference between the "Nursing Care Scale for Dying Patients and Their Families" pre- and post-test scores of the intervention and control groups.

H2: There is a significant difference between the pre-test and post-test scores of the "Nurse Difficulty Scale for Dying Patients and Their Families" of the intervention and control groups.

Eligibility criteria: Inclusion Criteria:

* Volunteer
* Working in a clinic where adult cancer patients are hospitalized for at least 1 year

Exclusion Criteria:

* On leave
* Not volunteering

Primary outcomes:
measure: The Nursing Care Scale for Dying Patients and Their Families [NCD]
timeFrame: 1 month
measure: The Nurse's Difficulty Scale for Dying Patients and Their Families [NDD]
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Adana
country: Turkey
facility: Cukurova University
Study officials:
affiliation: Cukurova University
name: Meltem Akbaş, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02843126: Combination of Trastuzumab and NK Immunotherapy for Recurrent Breast Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Recurrent Breast Cancer
Keywords: recurrent breast cancer
Her-2 positive
Trastuzumab
NK immunotherapy
Lead sponsor: Fuda Cancer Hospital, Guangzhou
Sponsor class: OTHER
Collaborators: name: Shenzhen Hank Bioengineering Institute
First posted: 2016-07-25
Enrollment: 30
Sex: FEMALE
Minimum age (years): 30
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is the safety and efficacy of Trastuzumab plus natural killer(NK) immunotherapy to recurrent breast cancer.

Detailed description: By enrolling patients who have breast cancer of Her-2 positive adapted to enrolled criteria, this study will document for the first time the safety and the short and long term efficacy of the combined therapy using Trastuzumab and NK cells.

The safety will be evaluated by statistics of adverse reactions. The efficacy will be evaluated according to local relief degree, progress free survival (PFS) and overall survival (OS).

Eligibility criteria: Inclusion Criteria:

* All standard therapies have failed according to NCCN guidelines or the patient refuses standard therapies after cancer recurrence
* Body tumor 1-6, the maximum tumor length \< 5 cm
* KPS ≥ 70, lifespan \> 6 months
* Platelet count ≥ 80×109/L，white blood cell count ≥ 3×109/L, neutrophil count ≥ 2×109/L, hemoglobin ≥ 80 g/L

Exclusion Criteria:

* Patients with cardiac pacemaker
* Patients with brain metastasis
* Patients with grade 3 hypertension or diabetic complication, severe cardiac and pulmonary dysfunction

Primary outcomes:
measure: Relief degree evaluated by the RECIST
timeFrame: 3 months
Secondary outcomes:
measure: Progress free survival (PFS)
timeFrame: 1 year
measure: Overall survival (OS)
timeFrame: 3 years
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Fuda cancer institute in Fuda cancer hospital
state: Guangdong
Study officials:
affiliation: Fuda Cancer Hospital, Guangzhou
name: Jibing Chen, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06748326: Laparoscopic Reduction of Intussusception in Children: Role in Primary Reduction After Failed Non-Surgical Therapies
Official title: Laparoscopic Reduction of Intussusception in Children: Role in Primary Reduction After Failed Non-Surgical Therapies
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Intussusception
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2024-12-27
Enrollment: 20
Sex: ALL
Minimum age (years): 1
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Children with intussusception that failed non surgical procedures and whose with recurrence
Primary purpose: TREATMENT

Brief summary: Laparoscopic Reduction of Intussusception in Children: Role in Primary Reduction after Failed Non-Surgical Therapies.

Detailed description: Intussusception is one of the main abdominal emergencies in children. Its diagnosis is usually based on the clinical features and confirmed either by U/S and /or barium enema and CT scan in rare occasion. Since the introduction of the hydrostatic reduction of intussusceptions by Ravitch in 1848, it became the gold standard management. However surgical intervention is required if this and other non-operative approaches fail. This typically involves 10 to 20% of cases. Early on, the approach has been through an open laparotomy and manual reduction of intussusception. Later, the introduction of the laparoscopy in the paediatric surgical field has added another dimension to the management of intussusception. In addition to its confirmed general benefits of less pain, better cosmoses, and low long-term risk of adhesive bowel obstruction, it also can be a diagnostic modality in certain cases, primary reduce the intussusception and in some cases to resect the pathological lead point or the damaged segment of bowel. The laparoscope allowed the surgeons to avoid unnecessary open procedures in cases of spontaneous reduction following enema reductions, obviating the need for an open procedure in up to 30% of cases. Despite of all mentioned above, its effectiveness has been questioned.

Eligibility criteria: Inclusion Criteria:

* 1. childs aged 1 year to 12 years with intussusception who failed the hydrostatic reduction.

Exclusion Criteria:

- 1. Childs with Bad general conditions ( coagulopathy, haemodynamic instability, and severe cardiopulmonary diseases).

2. Known primary disease e.g. lymphoma and major congenital anomalies. 3. Previous abdominal surgeries.

Primary outcomes:
measure: Results of Laparoscopy using in reduction of intussusception in children.
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06578026: Developing Resilience Skills and Social Competence in Youth in a School Setting
Official title: Developing Resilience Skills and Social Competence in Youth in a School Setting
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Psychosocial Functioning
Keywords: resilience
Lead sponsor: The Catholic University of America
Sponsor class: OTHER
First posted: 2024-08-29
Enrollment: 169
Sex: ALL
Minimum age (years): 9
Maximum age (years): 11
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Intervention model description: randomized control trial
Primary purpose: TREATMENT

Brief summary: Our study aimed to answer the question: Can a resilience-based intervention improve the psychosocial and educational outcomes of students with psychosocial difficulties? We examined the effectiveness of a resilience-based group intervention, the Resilience Builder Program® (RBP), with students in low-SES school settings to determine if this treatment improves psychosocial and educational outcomes.

Detailed description: Enhancing resilience is valuable to youth from economically marginalized communities given that they often face greater challenges and hardships than their peers from more affluent communities.

Efforts to increase resilience skills in these youth are hampered because they disproportionately encounter barriers in access to mental health interventions. Implementing school-based services may be optimal to address these inequalities. This project explores the effectiveness of a school-based group intervention (the Resilience Builder Program®) related to resilience and academic functioning in a sample of children from economically marginalized communities. Students (N = 169) with social-emotional difficulties were recruited from five elementary schools and randomly assigned to participate in the Resilience Builder Program® (RBP) immediately or following a semester delay. Participants, their parents, and teachers completed measures of resilience and academic functioning. Repeated-measures analysis of variance compares groups across time (pre-, post-intervention) on psychosocial and academic outcomes.

Eligibility criteria: Inclusion Criteria:

* psychosocial deficits

Exclusion Criteria:

* psychosis
* extreme aggression
* autism

Primary outcomes:
measure: Resiliency scales for children and adolescent (RSCA)
timeFrame: 1 month
Secondary outcomes:
measure: Behavior assessment system for children, 2nd edition (BASC)
timeFrame: 1 month
Other outcomes:
measure: Academic competence evaluation scales (ACES)
timeFrame: 1 month
Locations:
city: Rockville
country: United States
facility: Montgomery County Public Schools
state: Maryland
Study officials:
References:
Clinical trial NCT02382926: Reha Drive: Capacitive Electrocardiography in Car Seat in Cardiological Patients
Official title: Capacitive Electrocardiography in the Driver's Seat and Elevation of Vital Signs Via Camera During Cardiac Rehabilitation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiac Events
Keywords: capacitive electrocardiography
Eulerian Magnification Method
Lead sponsor: RWTH Aachen University
Sponsor class: OTHER
Collaborators: name: RWTH Aachen Institute of Medical Information Technology
First posted: 2015-03-09
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: In this trial contactless heart rate, electrocardiography and breathing rate measurements are elevated during car simulation in cardiac rehabilitation via automotive sensors and camera.

Detailed description: Increasing number of elderly people with cardiovascular diseases and the wish to drive a car need recommendations corresponding to their fitness of driving during cardiac rehabilitation. Little trial data are known, only a position paper of the German Cardiac Society (DGK) of 2010 discusses the aptitude of driving a car of cardiovascular patients on experience. For judgement and recommendations automotive monitoring via contactless sensors might be helpful. Therefore while "driving" in a simulator distinct heart circulation situations will be created. Vital signs will be measured via long term electrocardiography (ECG) in comparison to contactless capacitive ECG (cECG) measurements via embedded sensors in the car seat as well as heart rate and breathing rate measurements via camera.

Eligibility criteria: Inclusion Criteria:

* cardiologic diseases after acute event (e. g. myocard infarction, bypass surgery)
* rehabilitation in clinic "An der Rosenquelle"

Exclusion Criteria:

* dementia
* lack of language ability
* pregnancy
* implanted electric devices (as e.g. heart pacemaker, inverted cardiodefibrillator)

Primary outcomes:
measure: arrhythmia
timeFrame: 30 minutes
Secondary outcomes:
measure: Heart rate via contactless camera
timeFrame: 30 minutes
Other outcomes:
measure: Breathing rate via contactless camera
timeFrame: 30 minutes
Locations:
city: Aachen
country: Germany
facility: Clinic of Rehabilitation "An der Rosenquelle", Kurbrunnenstreet 5
state: North Rhine Westphalia
city: Aachen
country: Germany
facility: University Hospital Aachen, Department of Cardiology, Angiology, Pneumology and Intensive Medicine
state: North Rhine Westphalia
Study officials:
affiliation: University Hospital Aachen, Clinic of Cardiology, Angiology, Pneumology and Intensive Care Medicine
name: Sebastian Reith, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00748826: Remicade Safety Line (Study P03236)(COMPLETED)
Official title: Remicade Safety Line
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Arthritis, Rheumatoid
Lead sponsor: Merck Sharp & Dohme LLC
Sponsor class: INDUSTRY
First posted: 2008-09-09
Enrollment: 576
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The goal is to document all patients in the clinic that meet the inclusion criteria within the scope of the project.

Brief summary: The goal of this study is to implement instruments that would increase the treating physician's awareness of the necessary tuberculosis screening when starting a new patient on infliximab (Remicade) therapy who has not reacted sufficiently to disease-modifying preparations, including methotrexate.

Detailed description: This study used a non-probability sampling method.

Eligibility criteria: Inclusion Criteria:

* Patients with active rheumatoid arthritis confirmed with adequate clinical response(ACR) criteria who did not react sufficiently to disease-modifying preparations, including methotrexate, and who are receiving new treatment with infliximab.

Exclusion Criteria:

* As per Summary of Product Characteristics (SmPC)

Primary outcomes:
measure: Number of Participants Who Had the Mendel Mantoux Test as the First Screening Test for Active or Latent Tuberculosis (TB) Before Starting Treatment
timeFrame: Baseline
measure: Number of Participants Who Had the Tine Test as the First Screening Test for Active or Latent Tuberculosis Before Starting Treatment
timeFrame: Baseline
measure: Number of Participants Who Had the In-vitro TB Test as the First Screening Test for Active or Latent Tuberculosis Before Starting Treatment
timeFrame: Baseline
measure: Number of Participants Who Had a Chest X-ray as Part of TB Screening for Active or Latent Tuberculosis Before Starting Treatment
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02233426: Effect of Hypertonic Solutions on Allergic Rhinitis Patients
Official title: Do Hypertonic Solutions Have an Impact on Nasal Eosinophilia in Allergic Rhinitis Patients?
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Allergic Rhinitis
Keywords: allergic rhinitis
nasal steroid
hypertonic saline
eosinophil
symptom score
Lead sponsor: Namik Kemal University
Sponsor class: OTHER
First posted: 2014-09-08
Enrollment: 1000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Medical records of patients who admitted to the outpatient clinic of a tertiary referral center was enrolled.

Brief summary: The purpose of this study is to assess the effectivity of using hypertonic nasal solutions alone on the symptom scores and nasal eosinophil levels of allergic rhinitis patients, retrospectively.

Detailed description: The medical records of the patients who admitted to outpatient clinic of otorhinolaryngology department of a tertiary referral center were retrospectively investigated. The symptom scores and nasal eosinophil levels of the patients were recorded. Patients using hypertonic solutions alone or steroid nasal spray alone were compared.

Eligibility criteria: Inclusion Criteria:

* Patients with positive Prick's test to at least one allergen and diagnosed as having allergic rhinitis were included
* Patients who used hypertonic nasal solution alone for at least one month were included as sthe study group
* Patients who used nasal steroid spray alone or at least one month were included as sthe study group

Exclusion Criteria:

* Patients with a history of asthma, urticeria, eczama, diabetes mellitus, hypertension, COPD and other systemic diseases were excluded

Primary outcomes:
measure: The number of eosinophils in nasal secretions
timeFrame: The number of eosinophils in nasal secretions that was counted before the therapy and after the first month of therapy would be recorded
Secondary outcomes:
measure: Sinonasal Outcome Test (SNOT-22) questionairre scores
timeFrame: SNOT-22 scores obtained before the treatment and after the first month of treatment would be recorded
Other outcomes:
Locations:
city: Tekirdag
country: Turkey
facility: Namik Kemal University, Department of Otorhinolaryngology
Study officials:
affiliation: Namik Kemal University
name: Zafer Ciftci, Assist. Prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06360926: Improvement Image Quality for SuperSonic® MACH Ultrasound System
Official title: Improvement Image Quality for SuperSonic® MACH Ultrasound System
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Diagnosis
Lead sponsor: SuperSonic Imagine
Sponsor class: INDUSTRY
First posted: 2024-04-11
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The aim of this Study is to collect radiologist feedback to support the further development and improvement of the imaging modes implemented on the embedded software in the SuperSonic® Ultrasound System (including the probe).


Eligibility criteria: Inclusion Criteria:

* Subject is ≥ 18 years old and is able to understand and sign the informed consent form.
* Subject is a minor \< 18 years old and the legal representative has signed the informed consent form.
* Subject is scheduled for at least one or more routine ultrasounds.
* Subject is affiliated to National Social Insurance or a Health Insurance Regimen.

Exclusion Criteria:

* Subject is unable or unwilling to adhere to Study procedures.
* Subject or his/her legal representative if a minor is unable to express or understand informed consent.
* Subject is under legal protection
* Subject is deprived of liberty by judicial or administrative decision
* Subject undergoes psychiatric treatment under constraint
* Subject is admitted to a health or social establishment for purposes other than research
* Subject has latex allergy.
* Subject has an open wound, cut, and/or a rash which would preclude an ultrasound imaging procedure

Primary outcomes:
measure: Qualitative assessment of image quality
timeFrame: During ultrasound procedure
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Hôpital Necker-Enfants malades
state: Ile De France
Study officials:
References:
Clinical trial NCT07018726: Addressing Emotional Distress in Dyads of Persons With a Young Onset Dementia (YOD) and Their Care-partners
Official title: Addressing Emotional Distress in Dyads of Persons With a Young Onset Dementia (YOD) and Their Care-partners
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Young Onset Dementia
Keywords: Emotional Distress
Dyadic Intervention
Young Onset Dementia
Caregiving
Lead sponsor: Massachusetts General Hospital
Sponsor class: OTHER
First posted: 2025-06-12
Enrollment: 388
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the present investigation is to test the efficacy of a virtual, brief (6 sessions) dyadic (patient and care-partner together) intervention to prevent chronic emotional distress in dyads where one person is diagnosed with Young Onset Dementia (YOD). Through this study, we seek to address the unmet need of preventing chronic emotional distress in YOD dyads through a feasible, acceptable and credible program, and ideally enhance resiliency and improve wellbeing and quality of life in both members of the dyad.


Eligibility criteria: Inclusion Criteria:

* Between the ages of 18-65 at the time of enrollment \[both patient and care-partner\]
* Diagnosis of young-onset dementia (FTD, PPA, AD, PCA, etc.) with symptom onset prior to age 65 \[patient\]
* A designated care-partner willing and interested to participate \[both patient and care-partner\]
* Received YOD diagnosis in the past 6 month \[patient\]
* English fluency and literacy \[both patient and care-partner\]
* Cognitive ability to understand study and research protocol in order to consent to study participation \[both patient and care-partner\]
* Patient and/or caregiver exhibit emotional distress on screening (using HADS D and/or HADS A scores \> 7)

Exclusion Criteria:

* And additional, terminal diagnosis such as cancer
* Lack of access to internet and/or a device with a camera
* Current untreated or unstable severe mental health conditions like bipolar disorder, schizophrenia, or active substance use

Primary outcomes:
measure: Change in Emotional Distress
timeFrame: 0 weeks, 6 weeks, 12 weeks
Secondary outcomes:
measure: Change in Resiliency Factors (Mindfulness)
timeFrame: 0 weeks, 6 weeks, 12 weeks
measure: Change in Resiliency Factors (Individual Coping)
timeFrame: 0 week, 6 weeks, 12 weeks
measure: Change in Self-Efficacy
timeFrame: 0 weeks, 6 weeks, 12 weeks
measure: Changes in Relationship Quality
timeFrame: 0 weeks, 6 weeks, 12 weeks
Other outcomes:
Locations:
city: Boston
country: United States
facility: Massachusetts General Hospital (MGH)
state: Massachusetts
Study officials:
References: