Clinical trial NCT06632067: Sugammadex and Time to Extubation in Ophthalmic Surgery
Official title: Comparison of Sugammadex and Neostigmine for Time to Extubation in Adult Patients Undergoing Routine Ophthalmic Surgery Under General Anesthesia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: General Anesthesia Using Endotracheal Intubation
Ophthalmologic Surgical Procedure
Sugammadex
Neostigmine
Extubation Readiness
Keywords: sugammadex
general anesthesia
ophthalmologic surgical procedures
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
First posted: 2024-10-08
Enrollment: 262
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study included patients aged 18 years or older who underwent ophthalmic surgeries under general anesthesia with tracheal intubation between 2020 and 2022. Patients who received rocuronium as the sole neuromuscular blocking agent and were maintained with sevoflurane or desflurane and intravenous fentanyl were included. Based on the choice of reversal agent for neuromuscular blockade, patients were divided into two groups: the sugammadex group or the neostigmine group. Patients who underwent emergency surgery or combined surgeries with other specialties were excluded.

Brief summary: This study is to invastigate if patients treated with sugammadex compared to neostigmine/atropine would be extubate faster upon emergence of anesthesia.

Detailed description: This is a retrospective case-control study including patients aged 18 years or older who underwent ophthalmic surgeries under general anesthesia with tracheal intubation between 2020 and 2022. Patients who received rocuronium as the sole neuromuscular blocking agent and were maintained with sevoflurane or desflurane and intravenous fentanyl were included. Based on the choice of reversal agent for neuromuscular blockade, patients were divided into two groups: the sugammadex group or the neostigmine group. Patients who underwent emergency surgery or combined surgeries with other specialties were excluded. Patient characteristics, including age, gender, ASA classification, weight, and height, were collected. Anesthesia-related medications were recorded. The time points of anesthesia induction, start and end of surgery, reversal agent administration, and tracheal extubation were documented.

Eligibility criteria: Inclusion Criteria:

aged 18 years or older ophthalmic surgeries under general anesthesia with tracheal intubation between 2020 and 2022 received rocuronium as the sole neuromuscular blocking agent maintained with sevoflurane or desflurane and intravenous fentanyl

Exclusion Criteria:

emergency surgery combined surgeries with other specialties

Primary outcomes:
measure: Time From reversal to extubation
timeFrame: Time From reversal to extubation
measure: Time From the end of surgery to reversal
timeFrame: Time From the end of surgery to reversal
Secondary outcomes:
measure: Time From induction to the end of surgery
timeFrame: Time From induction to the end of surgery
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: China Medical University Hospital
Study officials:
affiliation: China Medical Univerity Hospital
name: Yi-Ying Chiang, MD
role: PRINCIPAL_INVESTIGATOR
References: