Clinical trial NCT04933994: Comparison of COVID-19 and H1N1 Influenza Pneumonia
Official title: Comparison of the Clinical and CT Features Between COVID-19 Pneumonia and H1N1 Influenza Pneumonia in Zhejiang, China
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID-19
H1N1 Influenza
Keywords: COVID-19, H1N1, Tomography, X-ray computed
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
Collaborators: name: Yueqing People's Hospital of Zhejiang Province
name: Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
name: Ruian People's Hospital of Zhejiang Province
name: The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
name: First Affiliated Hospital of Zhejiang University
name: Kecheng People's Hospital of Quzhou city, Zhejiang Province
name: Pingyang People's Hospital of Zhejiang Province
name: The First People's Hospital of Yuhang District, Hangzhou, Zhejiang Province
First posted: 2021-06-22
Enrollment: 483
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: pneumonia with COVID-19 pneumonia or H1N1 influenza

Brief summary: To explore the different clinical and CT features distinguishing COVID-19 from H1N1 influenza pneumonia.

Detailed description: COVID-19 pneumonia patients showed less proportions of underlying diseases, fever and respiratory symptoms than those of H1N1 pneumonia patients (p\<0.01). White blood cell count, neutrophilic granulocyte percentage, C-reactive protein, procalcitonin, D-Dimer and lactate dehydrogenase in H1N1 pneumonia patients were higher than those of COVID-19 pneumonia patients (p\<0.05). H1N1 pneumonia were often symmetrically located in the dorsal part of lung inferior lobes, while COVID-19 pneumonia were unsually showed a peripheral but non-specific lobe distributions. Ground glass opacity was more common in COVID-19 pneumonia and consolidation lesions was more common in H1N1 pneumonia (p\<0.01). COVID-19 pneumonia lesions showed a relative clear margin compared with H1N1 pneumonia. Crazy-paving pattern, thickening vessels, reversed halo sign and early fibrotic leisions were more common in COVID-19 pneumonia than H1N1 pneumonia (p\<0.05). Pleural effusion in COVID-19 pneumonia was significantly less common than H1N1 pneumonia (p\<0.01).

Compared with H1N1 pneumonia in Zhejiang, China, the clinical manifestations of COVID-19 pneumonia was more concealed with less underlying diseases and slighter respiratory symptoms. The more common CT manifestations of COVID-19 pneumonia included ground glass opacity with a relative clear margin, crazy-paving pattern, thickening vessels, reversed halo sign and early fibrotic leisions, while the less common CT manifestations of COVID-19 pneumonia included consolidation and pleural effusion.

Eligibility criteria: Inclusion Criteria:

* pneumonia

Exclusion Criteria:

* no pneumonia

Primary outcomes:
measure: Comparison of the clinical and CT features between COVID-19 pneumonia and H1N1 influenza pneumonia in Zhejiang, China
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
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