louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05392660: Upright Position During First Stage of Labour
Official title: Effect of Upright Position During First Stage of Labour On Labour Outcome: An Evidence Based Approach
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Effects of Movement
Keywords: First stage of labor
Upright position
Labor outcomes
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2022-05-26
Enrollment: 100
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: There are several physiological advantages for being upright during labour. These include the effect of gravity on the fetus within the uterus; reduced risk of aorto-caval compression this maximizes uterine blood ﬂow to the placenta and fetus during labour and more efficient contractions which lead to shorter first and second stage of labor. In addition, being upright during labour provide better alignment of the fetus; and increased pelvic outlet when the woman is in squatting and kneeling positions


Eligibility criteria: Inclusion Criteria:

* Primipara parturient women who admitted to delivery unit;
* in early active phase of 1st stage of labor (not more than 4cm),
* age between 20-35 years,
* had a single, viable, and full term (≥ 37 weeks),
* with normal fetal heart rate pattern (120-160 b/min),
* fetus in occipto anterior position
* free from medical or obstetrical disorders that may interrupt labor progress

Exclusion Criteria:

* Any women out of inclusion criteria

Primary outcomes:
measure: Intensity of labor pain assessed by Visual analogue pain intensity scale
timeFrame: during the procedure
measure: duration of first stage of labor
timeFrame: during the procedure
Secondary outcomes:
measure: duration of second stage of labor
timeFrame: immediately after intervention
measure: fetal outcome
timeFrame: during the procedure
measure: Neonatal outcome
timeFrame: immediately after intervention
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of nursing Cairo university
Study officials:
References:
Clinical trial NCT04365660: 18F-FTC-146 PET/CT in Newly-Diagnosed Osteosarcoma
Official title: A Phase 2 Study of 18F FTC 146 PET/CT in Patients With Newly Diagnosed Osteosarcoma
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
Conditions: Osteosarcoma
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2020-04-28
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this research is to evaluate the study drug, 18F FTC-146, as a positron emission tomography (PET) / computed tomography (CT) radiotracer imaging agent to evaluate tumor status in patients newly diagnosed with osteosarcoma ("bone cancer").

Detailed description: Primary Objective: Demonstrate correlation of pre-post reduction in 18F-FTC-146 PET/CT with amount of post-treatment tumor necrosis in newly-diagnosed and treated osteosarcoma patients.

Secondary Objective: Demonstrate correlation of pre-post reduction in 18F-FTC-146 PET/CT with amount of post-treatment pain reduction in newly-diagnosed and treated osteosarcoma patients.

Eligibility criteria: Inclusion Criteria:

* Patients with biopsy proven osteosarcoma requiring local surgical intervention.
* ECOG ≤ 2
* Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

* Chemotherapy in the past 2 months.
* Prior history of allergic reaction to 18F FTC 146.
* Pregnant or nursing

Primary outcomes:
measure: Detection of Tumor Necrosis Post-chemotherapy
timeFrame: 12 weeks
Secondary outcomes:
measure: Maximum Standardized Uptake Value (SUVmax)
timeFrame: 12 weeks
measure: Use of Patient Reported Outcomes Measurement Information System (PROMIS) to Assess Treatment Effect
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University
state: California
Study officials:
affiliation: Stanford Universiy
name: Kristen N Ganjoo
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03893994: Effect Of Stretching Programme On Shoulder Performance In Volleyball Players With Posterior Shoulder Tightness
Official title: Effect Of Stretching Programme On Shoulder Performance In Volleyball Players With Posterior Shoulder Tightness
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Posterior Shoulder Tightness
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2019-03-28
Enrollment: 34
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: When the dominant arm is compared with the non-dominant arm in overhead athletes there is a serious internal rotation limitation in the dominant arm. Due to overhead activity, adaptive changes in shoulder joint mobility and flexibility are indicated. Internal rotation limitation is often associated with increased external rotation. One of the reason of this adaptive change is posterior shoulder tightness which is common in overhead athletes as well as in volleyball players. The aim of this study is to determine the effect of stretching program on the range of motion, flexibility of posterior shoulder muscles and functional performance.


Eligibility criteria: Inclusion Criteria:

* Posterior shoulder tightness ( 15 degree internal rotation limitation compared with non dominant side)
* Being a professional volleyball player ( at least 3 years experience in the professional league)
* At least having 4 training days in a week
* negative impingement tests ( Hawkins, Neer or Jobe)
* No shoulder pain

Exclusion Criteria:

* Having any shoulder surgery
* Having a shoulder injury in last 6 months
* Having any neck problem or neck pain
* Having a systemic illness
* Sublocated shoulder

Primary outcomes:
measure: Mean change from baseline in shoulder internal ROM measurement with digital inclometery at 6 weeks
timeFrame: 6 weeks
Secondary outcomes:
measure: Mean change from baseline in muscle hardness (kPA) with elastography at 6 weeks
timeFrame: 6 weeks
measure: Mean change from baseline in distance scores on single arm shot put test at 6 weeks
timeFrame: 6 weeks
measure: Mean change from baseline in velocity (km/h) of spike with radar at 6 weeks
timeFrame: 6 weeks
measure: Mean change from baseline in strength ( Nm/kg) of shoulder internal rotation and external rotation at 6 weeks
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Turkish Volleyball Federation
Study officials:
References:
Clinical trial NCT00082160: Brain Imaging Technology to Examine the Effects of Meditation
Official title: fMRI Investigation of Meditation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: Meditation
Relaxation
Lead sponsor: National Center for Complementary and Integrative Health (NCCIH)
Sponsor class: NIH
First posted: 2004-05-04
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: DEFINED_POPULATION
Time perspective: OTHER

Brief summary: The purpose of this study is to use brain imaging technology to identify the parts of the brain that are activated during meditation and to compare these parts to those activated during other activities. This study will also determine the effects of meditation on involuntary functions, such as breathing.

Detailed description: Meditation and relaxation-based interventions are becoming more widely accepted in clinical settings because of their low cost, low risk, and proven effectiveness as a complementary intervention in a wide range of diseases. Despite the success and growing use of relaxation-based treatments, few studies have addressed the basic mechanism by which these treatments work. This study will use functional magnetic resonance imaging (fMRI) to define the brain mechanisms underlying the meditative state, to differentiate this state from other states, and to determine how meditation-induced brain changes affect autonomic function.

Participants in this study will have an fMRI brain scan. Brain activity, breathing rate, and heart rate will be measured while the participant engages in three different activities: lying quietly, meditating, and mentally generating numbers.

Eligibility criteria: Inclusion Criteria:

* Daily practice of Vipassana or Kundalini meditation for at least 1 year and participation in at least one 1-week meditation retreat

Exclusion Criteria:

* Current medical or psychological illness
* Use of antidepressants, antianxiolytics, or compounds that alter cerebral blood flow
* Claustrophobia
* Pregnancy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: Massachusetts General Hospital
state: Massachusetts
Study officials:
affiliation: Massachusetts General Hospital Department of Psychiatry
name: Sara Lazar, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01029860: The Impact of Hospitalization on Ambulatory Blood Pressure and Intraocular Pressure
Official title: A Study Investigating the Impact of Hospitalization on Ambulatory Blood Pressure and Intraocular Pressure in Subjects With Mild to Moderate Arterial Hypertension and Untreated Ocular Hypertension
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Blood Pressure
Keywords: Hypertension
Ambulatory measurement
Lead sponsor: Aristotle University Of Thessaloniki
Sponsor class: OTHER
First posted: 2009-12-10
Enrollment: 40
Sex: ALL
Minimum age (years): 30
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Subjects with untreated ocular hypertension and stage 1 arterial hypertension with or without treatment with anti-hypertensive agents.

Brief summary: The purpose of this study is to assess the effect of hospital admission on 24-hour ambulatory blood pressure (ABP) in hypertensive subjects.Treated or untreated hypertensive adults with open angle glaucoma underwent in-hospital and outpatient 24-hour ABP monitoring, in random order 4 weeks apart.


Eligibility criteria: Inclusion Criteria:

* age \>30 years old.
* subject has signed an informed consent.
* patient has untreated ocular hypertension (IOP at 10:00 between 22-34 mm Hg)
* patient has stage 1 arterial hypertension with or without therapy

Exclusion Criteria:

* secondary hypertension.
* stage 2 or 3 hypertension, history of renal disease.
* sleep apnea.
* diabetes mellitus
* acute or chronic inflammation.
* myocardial infarction or unstable angina within the past 6 months.
* heart failure NYHA class III-IV.
* active liver disease.
* pregnancy.
* history of drug or alcohol abuse, or any other condition with poor prognosis.
* treatment with non-steroid anti-inflammatory agents, corticosteroids, beta-blockers, or any other regimen that could affect BP levels.
* smoking

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04515160: Correlation of Clinical Frailty Scale and Modified Frailty Index in Intensive Care Patients
Official title: Correlation of Clinical Frailty Scale and Modified Frailty Index in Intensive Care Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Frailty
Lead sponsor: Diskapi Yildirim Beyazit Education and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2020-08-17
Enrollment: 200
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: intensive care patients

Brief summary: The purpose of our study is to evaluate the correlation of the Clinical Frailty Scale, which is a judgment-based measure, and the Modified Frailty Index, which interrogates the patient's current diseases, in the frailty assessment of intensive care patients and the effect on the estimation of mortality, mechanical ventilation need, intensive care stay, hospital stay and discharge status.


Eligibility criteria: Inclusion Criteria:

* intensive care patients

Exclusion Criteria:

* patients with a life expectancy of less than 24 hours
* Do not speak Turkish

Primary outcomes:
measure: Frailty
timeFrame: in the first 24 hours of intensive care admissions
Secondary outcomes:
measure: mortality
timeFrame: the patient will be monitored for 1 year and the exitus time will be recorded
measure: intensive care stay
timeFrame: the patient will be monitored for 1 year and the intensive care stay will be recorded
measure: discharge status
timeFrame: the patient will be monitored for 1 year and the discharge status will be recorded
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: DiskapiYBERH
Study officials:
References:
Clinical trial NCT00716560: Nausea and Vomiting In Patients Receiving Consecutive Days of Cisplatin
Official title: Nausea and Vomiting In Patients Receiving Consecutive Days of Cisplatin
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Metastatic Melanoma
Nausea
Lead sponsor: Thomas Jefferson University
Sponsor class: OTHER
Collaborators: name: Merck Sharp & Dohme LLC
First posted: 2008-07-16
Enrollment: 8
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: University practice patients with metastatic melanoma

Brief summary: The purpose of this study is to observe the incidence of nausea with systemic chemotherapy that includes consecutive days (more than one day)of cisplatin medication.

Detailed description: Questionnaires are completed on week of chemotherapy treatment referred to as Dartmouth regimen.

Eligibility criteria: Inclusion Criteria:

* confirmed diagnosis metastatic melanoma
* 18 years and older
* undergoing chemotherapy with Dartmouth regimen
* medically stable to receive chemotherapy per physical and clinical laboratory tests

Exclusion Criteria:

* No medical conditions that interfere with assessment of nausea and vomiting during chemotherapy
* No cognitive disorder that impairs symptom assessment
* No other investigational agent
* Inability to swallow medications for nausea and vomiting
* No gastric outlet obstruction

Primary outcomes:
measure: Determine incidence of nausea when receiving Dartmouth regimen chemotherapy for metastatic melanoma
timeFrame: Week of treatment
Secondary outcomes:
measure: Assess the impact of systemic chemotherapy with Dartmouth regimen on quality of life of patients
timeFrame: week of treatment
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Thomas Jefferson University Hospital
state: Pennsylvania
Study officials:
affiliation: Thomas Jefferson University
name: Takami Sato, M.D.,Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03486860: A Multi-Method Early Intervention Program for Inhibited and Anxious Preschoolers
Official title: A Multi-Method Early Intervention Program for Inhibited and Anxious Preschoolers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Behavioral Inhibition
Anxiety
Lead sponsor: University of Maryland, College Park
Sponsor class: OTHER
First posted: 2018-04-03
Enrollment: 51
Sex: ALL
Minimum age (years): 42
Maximum age (years): 60
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This project aims to develop and evaluate a novel early intervention program that targets the specific risk factors implicated in the development and persistence of shyness, social reticence, and withdrawal in children. The project includes a program development phase, Phase I (pilot test of full study procedures using developed treatment protocol), and Phase II (randomized controlled trial/RCT). Outcomes that will be assessed include change in child behavioral inhibition and parenting, using parent and teacher reports and observational data. Families are assessed at three time points: baseline, post-treatment (or at approximately 8 weeks for the control group), and 2 month follow-up.


Eligibility criteria: Inclusion Criteria:

* Child must be attending preschool; child must score within top 15% on parent-rated Behavioral Inhibition Questionnaire; child has a biological parent with at least 50% physical custody who consents to participate

Exclusion Criteria:

* Child has a diagnosis of pervasive developmental disorder or mental retardation; child scores above clinical cutoff on Social Communication Questionnaire; child is currently receiving treatment for anxiety

Primary outcomes:
measure: Change in child anxiety disorder symptoms
timeFrame: Pre-treatment (baseline), post-treatment (week 8), and 2-month follow-up
Secondary outcomes:
Other outcomes:
Locations:
city: College Park
country: United States
facility: University of Maryland
state: Maryland
Study officials:
affiliation: University of Maryland
name: Andrea Chronis-Tuscano, Ph.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Maryland
name: Kenneth Rubin, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06349460: Trial to Optimize Just-in-Time Adaptive Intervention for Binge Eating & Weight-related Behaviors
Official title: A Micro-Randomized Trial to Optimize Just-in-Time Adaptive Intervention for Binge Eating & Weight-related Behaviors
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Binge Eating
Obesity
Lead sponsor: Northwestern University
Sponsor class: OTHER
Collaborators: name: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
First posted: 2024-04-05
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Intervention model description: In this micro-randomized trial, participants will have 2 consecutive, independent micro-randomizations at the time of target selection each week for 16 weeks: namely, 1 of 5 treatment targets will be randomly delivered, either as a recommended or assigned target, to each user, of equal probability per randomization.
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to conduct a micro-randomized trial to learn which evidence-based targets within a mobile intervention for binge eating and weight-related behaviors are most impactful for which people and in what sequence.


Eligibility criteria: Inclusion Criteria:

* Adults age 18 years or older
* Obesity (BMI ≥30)
* Recurrent binge eating (≥12 episodes in the past 3 months)
* Interested in losing weight and reducing binge eating
* Willing to use a mobile application
* Has a smartphone with Internet access and capacity for calls and text messaging
* Has a valid email address
* Has access to a scale
* Not pregnant
* English-speaking

Exclusion Criteria:

* Diagnosis for which the study/intervention is not clinically indicated
* Not currently receiving clinical services for weight management or binge eating

Primary outcomes:
measure: Weekly change in binge eating
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Northwestern University Feinberg School of Medicine
state: Illinois
Study officials:
References:
Clinical trial NCT03822260: Evaluation of Neuroinflamation of SAH
Official title: Comparasion of Bio-markers and Neuroimaging Changes Caused by Neuroenflamation After the Aneurysmal Subarachnoid Hemorrhage
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Lead sponsor: Bezmialem Vakif University
Sponsor class: OTHER
First posted: 2019-01-30
Enrollment: 54
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients admitted to the emergency room of the universty hospital with aSAH have a CBC and blood sample performed on admission. Blood samples are obtained significant days (1,4-14 days) thereafter during their hospitalization.

Brief summary: The investigators are planning that can these markers be used a predictive marker at SAH and for this aim we will study both patiens' blood sample and their CT image.

Detailed description: An ideal marker which could be used clinically should meet numerous criteria, such as high sensitivity or the possibility of easy and quick assessment of its concentration in blood or blood plasma.The Fisher's scale presents an alternative for evaluating patients with subarachnoid hemorrhage . The investigator are going to evaluate both plasma markers and fishers scale at SAH.

Eligibility criteria: Inclusion Criteria:

* Ruptured Subarachnoid Aneursym

Exclusion Criteria:

* without aneursymal sah
* Patient's positive for rheumatoid factor and anti-CCP or with chronic inflammatory diseases (such as ankylosing spondylitis or rheumatoid arthritis), systemic diseases (such as hypercholesterolemia, hypertension, diabetes mellitus, myocardial infarction, stroke, peripheral artery disease), active infection, a history of term medication, trauma to the hip and smoking were excluded from the study.

Primary outcomes:
measure: Diagnostic marker identification
timeFrame: 24 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01833260: Music and Perceived Rate of Exertion
Official title: Influence of a Distractive Auditory Stimulus on the Rate of Exertion During Pulmonary Rehabilitation Sessions
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COPD
Lead sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sponsor class: OTHER
First posted: 2013-04-16
Enrollment: 50
Sex: ALL
Minimum age (years): 45
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The aim of this study was to evaluate the effect of listening to ambient music on the perceived exertion rate during pulmonary rehabilitation for chronic obstructive pulmonary disease patients.


Eligibility criteria: Inclusion Criteria:

* participate in the program for at least one month after the initial medical investigation, be free of exacerbations for 1 month and have maintained exactly the same program session for both evaluated sessions

Exclusion Criteria:

* participate to only session of one condition

Primary outcomes:
measure: Rate of exertion
timeFrame: After 1 hour
Secondary outcomes:
measure: Dyspnea
timeFrame: After 1 hour
measure: Hospital Anxiety Depression Scale
timeFrame: After 1 hour
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: Cliniques universitaires Saint-Luc
Study officials:
References:
citation: Reychler G, Mottart F, Boland M, Wasterlain E, Pieters T, Caty G, Liistro G. Influence of ambient music on perceived exertion during a pulmonary rehabilitation session: a randomized crossover study. Respir Care. 2015 May;60(5):711-7. doi: 10.4187/respcare.03671. Epub 2015 Jan 13.