Clinical trial NCT06714201: CUrrent Practices of Intensive Care for the Management of Acute Respiratory Distress Syndrome in EurOpe.
Official title: CUrrent Practices of Intensive Care for the Management of Acute Respiratory Distress Syndrome in EurOpe.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: ARDS (Acute Respiratory Distress Syndrome)
Keywords: ARDS
Prone position
ECMO
ECCO2R
vvECMO
vv-ECMO
Mechanical Ventilation
Tidal volume
Lead sponsor: Universitätsklinikum Hamburg-Eppendorf
Sponsor class: OTHER
Collaborators: name: Università degli Studi di Trento
name: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
name: University of Genova
name: University of Hamburg-Eppendorf
First posted: 2024-12-03
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population consists of healthcare professionals directly involved in the management of ARDS patients in European ICUs. This includes a multidisciplinary group of:

* Physicians at various levels of responsibility and expertise, such as medical directors, senior physicians, attending consultants, and assistant physicians.
* ICU nurses actively participating in the care and management of ARDS patients. To ensure broad and representative participation, we will collaborate with national representatives who are engaged in ARDS research. These representatives will be instrumental in leveraging their professional networks to facilitate access to local clinicians working in ICUs. By doing so, we aim to capture a diverse and comprehensive range of clinical practices and insights into the management of ARDS across Europe.

Brief summary: This study seeks to gain a comprehensive understanding of current ARDS management practices across European ICUs, with a particular focus on the use of LTV and PP therapy, which have been shown to improve outcomes in ARDS patients. The primary objectives focus on evaluating how LTV and PP are implemented across different institutions, while secondary objectives encompass a broader assessment of other ARDS treatment strategies. These include mechanical ventilation approaches, including PEEP titration, the use of NMBAs, and advanced extra-corporal therapies like ECMO and extracorporeal carbon dioxide removal (ECCO2R). Additionally, the study will explore diagnostic methods and decision-making processes that guide ARDS management in diverse clinical settings.

Detailed description: This is a cross-sectional survey designed to collect data on the current practices of ARDS management in ICUs across Europe. The survey will be administered electronically, allowing for the efficient collection of responses from a broad and diverse group of healthcare professionals.

Eligibility criteria: Inclusion Criteria:

• Healthcare professionals (physicians and nurses) who are currently employed in an ICU that treats ARDS patients and are actively involved in their management.

Exclusion Criteria:

• There are no specific exclusion criteria for this study, as the aim is to gather as broad a range of perspectives and practices as possible from ICUs treating ARDS patients.

Primary outcomes:
measure: Proportion of ICUs utilising prone positioning for ARDS patients.
timeFrame: Survey period (December 2024 - March 2025)
measure: PaO2/FiO2 threshold for starting prone positioning.
timeFrame: Survey period (December 2024 - March 2025)
measure: Distribution of the extent of prone positioning used in participating ICUs.
timeFrame: Survey period (December 2024 - March 2025).
measure: Mean duration per prone positioning cycles.
timeFrame: Survey period (December 2024 - March 2025)
measure: Mean minimum number of prone position cycles.
timeFrame: Survey period (December 2024 - March 2025)
measure: Commonly reported criteria for ending prone positioning therapy.
timeFrame: Survey period (December 2024 - March 2025)
measure: Proportion of ICUs adhering to tidal volume restrictions
timeFrame: Survey period (December 2024 - March 2025)
measure: Mean tidal volumes used for mild, moderate, and severe ARDS.
timeFrame: Survey period (December 2024 - March 2025)
Secondary outcomes:
measure: Proportion of ICUs using volume-controlled vs pressure-controlled ventilation.
timeFrame: Survey period (December 2024 - March 2025)
measure: Types of PEEP titration methods and recruitment manoeuvres.
timeFrame: Survey period (December 2024 - March 2025)
measure: Proportion of ICUs using NMBAs for ARDS patients.
timeFrame: Survey period (December 2024 - March 2025).
measure: Frequency of corticosteroid and nitric oxide use.
timeFrame: Survey period (December 2024 - March 2025)
measure: Proportion of ICUs with ECMO/ECCO2R availability and implementation.
timeFrame: Survey period (December 2024 - March 2025).
measure: Variation in prone position extent by country.
timeFrame: Survey period (December 2024 - March 2025).
Other outcomes:
Locations:
Study officials:
References: