Clinical trial NCT05748457: Akershus University Hospital Retrospective Cohort Study of Family Based Treatment
Official title: Changes in Outcomes of Treatment for Adolescent Anorexia Nervosa After Implementation of Family Based Treatment in a Norwegian Child and Adolescent Mental Health Service: A Retrospective Cohort Study With Prospective Follow-up
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Anorexia Nervosa
Atypical Anorexia Nervosa
Lead sponsor: University Hospital, Akershus
Sponsor class: OTHER
Collaborators: name: Rådgivning om Spiseforstyrrelser
First posted: 2023-02-28
Enrollment: 28
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients initiating treatment during the years 2015-2020 with the eating disorder team at Nedre Romerike outpatient clinic at Akershus university hospital, Department of child and adolescent mental health services.

Brief summary: The goal of this observational study is to compare short and long-term effects of manualised Family Based Treatment for adolescent anorexia nervosa to those of non-manualised family therapy. The study will approach former patients who were treated before and after Family Based Therapy was adopted in an outpatient clinic, and extract data from electronic health records and public registries.

Detailed description: A two-group retrospective exploratory cohort study with longitudinal follow-up comparing adolescents with anorexia nervosa treated with generic family therapy to those treated with the manualised Family Based Treatment (FBT). The primary aim is to investigate whether adoption of FBT has led to faster normalisation of weight and lower rates of eating disorder in early adulthood. Secondary aims are to investigate whether implementation of FBT has changed the time to discharge, heterogeneity of patient weight change across treatment, rates of adverse events, rates of readmission, patient experiences of the treatment, long term functional outcomes and mortality. Data are extracted from patient health records, reported by participants and extracted from public registries.

Eligibility criteria: Inclusion Criteria:

• Clinical diagnosis of F50.0 Anorexia nervosa or F50.1 Atypical anorexia nervosa according to the International Classification of Diseases-10.

Exclusion Criteria:

• Patient was treated during the years 2018-2020 and FBT was never initiated according to patient health records.

Primary outcomes:
measure: Time to weight restoration
timeFrame: Assessed retrospectively at enrolment.
Secondary outcomes:
measure: Time to discharge from treatment
timeFrame: Assessed retrospectively at enrolment.
measure: Time to readmission to treatment
timeFrame: Assessed retrospectively at enrolment.
measure: Mortality
timeFrame: Assessed 5, 10, 15 and 20 years post treatment.
measure: Level of education
timeFrame: Assessed 5, 10, 15 and 20 years post treatment.
measure: Employment status and welfare benefits
timeFrame: Assessed 5, 10, 15 and 20 years post treatment.
measure: Treatment for eating disorder in adulthood
timeFrame: Assessed 5, 10, 15 and 20 years post treatment.
Other outcomes:
measure: Participant experiences and satisfaction with services
timeFrame: Assessed retrospectively at enrolment.
Locations:
city: Lillestrøm
country: Norway
facility: Nedre Romerike BUP
Study officials:
affiliation: University Hospital, Akershus
name: Erling W Rognli, PhD
role: PRINCIPAL_INVESTIGATOR
References: