Clinical trial NCT03373357: Hypertension and Cardiovascular Risk Associated With Obstructive Sleep Apnea in Adult in Guadeloupe (French West Indies)
Official title: Hypertension and Cardiovascular Risk Associated With Obstructive Sleep Apnea in Adult in Guadeloupe (French West Indies)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Hypertension Arterial
Keywords: sleep apnea
arterial hypertension
cardiovascular risk
Lead sponsor: Centre Hospitalier Universitaire de la Guadeloupe
Sponsor class: OTHER
First posted: 2017-12-14
Enrollment: 220
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: All the patients will have sampling blood specific to the protocol:

* Insulinémie
* US CRP(TEACHERS' CENTRE)
* Implementation of a sérothèque
Primary purpose: OTHER

Brief summary: The MAPA is the reference method to estimate the PA during the SAHOS. The MAPA can be recommended over 48 hours: indeed, the PA falls at the beginning of every apnea then increases gradually up to a pressif peak arising at the time of the ventilatoire resumption. These variations arise under the influence of 4 stimulus: the désaturation in O2, the rise of the PaCO2, the increase of the respiratory effort and the microawakening of the end of apnea who are at the origin of a sympathetic stimulation.

Consequently a better diagnostic approach of the HTA (confirmation of a resistant HTA, an identification of the masked HTA and the patients " not dipper " by the MAPA), the identification of the SAHOS, and a better coverage) of the associated cardiovascular risk factors are essential and establish a stake in public health.

To investigator's knowledge, no datum or study on the association HTA-SAHOS and its consequences was until then realized in the French overseas departments.

Detailed description: In Guadeloupe, data on the relationships between arterial hypertension and obstructive sleep apnea are unavailable. The aim of this study was: to assess the frequency of hypertension and non-dipper pattern evaluated by 48-hour ambulatory blood pressure monitoring in an adult population identified obstructive sleep apnea/non-obstructive sleep apnea during overnight polygraphy ; to determine the cardio-metabolic factors associated with obstructive sleep apnea.

Eligibility criteria: Inclusion Criteria:

* Patient suspected of SAHOS;
* Patient or third-party responsible for receiving information on the study and who signed informed consent ;
* Patient age over 18 years; Patient living in Guadeloupe.

Exclusion Criteria:

* Patient non-affiliated to the social security scheme ;
* Patient with obstructive bronchopneumopathy, neuro-muscular pathology,
* central and mixed SAS, cardiac arrhythmia,
* systemic and chronic inflammatory syndrome ; -
* Pregnant and lactating patient ;
* patient in emergency.

Primary outcomes:
measure: the frequency of hypertension
timeFrame: At the of the enrollment period, an average of 3 years", etc.).
Secondary outcomes:
measure: The cardio-metabolic factors
timeFrame: "through study completion, an average of 8 years"
Other outcomes:
Locations:
city: Pointe-à-Pitre
country: Guadeloupe
facility: Hospital University Center of Pointe-à-Pitre
Study officials:
affiliation: Hospital University Center of Pointe-à-Pitre
name: Rachel BILLY BRISSAC, Dorctor cardiovascular
role: PRINCIPAL_INVESTIGATOR
References: