louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02111148: Vaginal Fluid Wash in Pre-labour Rupture of Membranes
Official title: Urea and Creatinine Versus Nitrazine Test in Vaginal Fluid Wash in Diagnosed Pre Labour Rupture of Membranes
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Disorder of Amniotic Cavity and/or Membrane
Keywords: rupture of membranes, nitrazine, urea, creatinine
Lead sponsor: Beni-Suef University
Sponsor class: OTHER
Collaborators: name: Cairo University
First posted: 2014-04-11
Enrollment: 105
Sex: FEMALE
Minimum age (years): 30
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The investigators assess in this study the sensitivity of Urea and Creatinine and that of Nitrazine test in vaginal wash after injecting saline in the vagina of patients with pre-labour rupture of membranes

Detailed description: The aim of this study is to compare the accuracy of measuring the urea and creatinine level versus that of nitrazine test in vaginal wash of pre-labour rupture of membranes patients.Each patient with rupture of membranes will be assessed clinically and then if not in labour , patients will be divided into 2 groups, 5ml saline will be injected in the vagina of each patient in every group then the vaginal wash will be collected in a test tube. Urea and creatinine group, biochemical tests for urea and creatinine in mIU/ml to detect their presence in the wash will be done. In Nitrazine group wash will be assessed by nitrazine paper showing bluish discoloration in rupture membranes. Sensitivity of each test in diagnosed rupture of membranes will be assessed.Which means how many patients in each test show positive results in case of diagnosed case.

Eligibility criteria: Inclusion Criteria:

* Gestational age between 28 and 41 weeks
* Single intrauterine pregnancy
* History of gush of fluid
* Liquor detected on speculum examination

Exclusion Criteria:

* Vaginal bleeding
* Patients in labour
* Contaminated samples

Primary outcomes:
measure: Urea and creatinine in vaginal fluid
timeFrame: Within first 24 hours after rupture of membranes in third trimester
Secondary outcomes:
measure: Nitrazine test
timeFrame: Within first 24 hours after rupture of membranes in third trimester
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Nesreen Abdel Fattah Abdullah Shehata
Study officials:
affiliation: Beni-Suef University
name: Nesreen A Shehata, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06639048: Social Media and Eating Disorder Fear
Official title: Is There a Relationship Between Individuals' Social Media Use and Their Fears of Eating Disorders?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Eating Disorder
University Students
Social Media
Eating Behavior
Fear
Keywords: social media
eating disorder
fear
Lead sponsor: Ankara Yildirim Beyazıt University
Sponsor class: OTHER
First posted: 2024-10-15
Enrollment: 799
Sex: ALL
Minimum age (years): 19
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Ankara Yıldırım Beyazıt University, Faculty of Health Sciences students

Brief summary: The goal of this observational study is to learn about the relationship between social media use and fear of eating disorders in university students. The main question it aims to answer is:

Is there a relationship between social media use and eating disorder fears in university students?

University students will answer a questionnaire face to face, including questions about their social media usage habits, the impact of social media on eating behavior scale, and the fears of eating disorders scale.


Eligibility criteria: Inclusion Criteria:

* Using social media

Exclusion Criteria:

* Pregnant or lactating individuals

Primary outcomes:
measure: Social media usage habits
timeFrame: Baseline
measure: Eating Disorder Fear Questionnaire
timeFrame: Baseline
measure: Effects of social media on eating behavior scale
timeFrame: Baseline
Secondary outcomes:
measure: Demographic characteristics
timeFrame: Baseline
measure: Body weight
timeFrame: Baseline
measure: Height
timeFrame: Baseline
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara Yıldırım Beyazıt University
state: Çubuk
Study officials:
affiliation: Ankara Yildirim Beyazıt University
name: Rahime E Karakaya, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00478348: Should Prosthetic Repair of Incisional Abdominal Hernias be Drain or Not?
Official title: Adequacy of Drainage During Prosthetic Repair of Incisional Abdominal Hernias: a Randomized Controlled Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postoperative Complications
Hernia
Keywords: Postoperative Complications
Drainage
Infection
Seroma
Hematoma
Recurrence
Abdominal Wall
Hernia
Surgical Mesh
Lead sponsor: University of Lausanne Hospitals
Sponsor class: OTHER
First posted: 2007-05-24
Enrollment: 200
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to determine whether drainage after prosthetic repair of incisional abdominal hernias increases or decreases complications such as infection, seromas and hematomas.

Detailed description: Between 3 to 20% of patients who received a midline laparotomy will develop an incisional hernia.

Primary suture of the defect is associated with a recurrence rate between 25 and 50%.Mesh repair is superior with regard to the recurrence (12-20%), but early postoperative complications include infections, hematomas and seromas.

Some advocate the use of drains in order to diminish secretions and complications. Other claim that drains increase the complication's rate.

In the absence of a randomized controlled trial it's not clear whether drainage could influence positively or negatively the occurence of such complications when performing a prosthetic repair of abdominal incisional hernia.

The aim of this study is to answer this question, comparing prospectively two groups of operated patients: the former with drainage and the latter without.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of midline abdominal wall incisional hernia
* Adults of 20 to 80 years old
* ASA I to III
* Inform consent signed by the patient and investigators

Exclusion Criteria:

* Incisional hernia less than 2 cm
* Groin hernia
* Antibiotic treatment before and during hospital admission
* Emergency admission for strangulated incisional hernia
* Immunosuppressing treatment

Primary outcomes:
measure: Evidence of early clinical infection, hematoma, seroma or recurrence confirmed by ultrasonography or/and laboratory findings.
timeFrame: 30 days
Secondary outcomes:
Other outcomes:
Locations:
city: Lausanne
country: Switzerland
facility: Department of Visceral Surgery, University Hospital Center
state: Vaud
Study officials:
affiliation: Department of Visceral Surgery, University Hospital Center, Lausanne, Switzerland
name: Nicolas Demartines, MD
role: STUDY_CHAIR
References:
Clinical trial NCT00401648: Effect of Brivaracetam in Photosensitive Epileptic Subjects
Official title: A Placebo-controlled, Single-blind, Multi-center Study to Explore the Photoparoxysmal Response in Photosensitive Epileptic Subjects After One Single Oral Dose of Brivaracetam in Capsules.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Epilepsy
Keywords: POC
photosensitive
epileptic
brivaracetam
PPR
AED
Lead sponsor: UCB Pharma
Sponsor class: INDUSTRY
First posted: 2006-11-20
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: to assess the effect of brivaracetam on the photoparoxysmal EEG response in photosensitive epileptic subjects


Eligibility criteria: Inclusion Criteria:

* epileptic subjects with generalized PPR

Exclusion Criteria:

* more than 2 concomitant antiepileptic drugs

Primary outcomes:
measure: Identify lowest single oral dose producing maximal decrease or suppression of intermittent photic stimulation (IPS)photoparoxysmal response (PPR) in photosensitive epileptic subjects pre-dose
measure: post placebo during 24h and post brivaracetam for up to 72 h
Secondary outcomes:
measure: Assess relationship between plasma concentrations and changes in photosensitivity frequency range, time of onset and duration of suppressing effect
measure: Safety
Other outcomes:
Locations:
city: Marseille
country: France
city: Paris
country: France
city: Rouen
country: France
city: Strasbourg
country: France
city: Kork
country: Germany
Study officials:
affiliation: UCB Pharma
name: Philipp von Rosenstiel, MD.
role: STUDY_DIRECTOR
References:
Clinical trial NCT01463748: Effects of Graptopetalum Paraguayense E. Walther on the Oxidative Stress, Antioxidant Enzyme Activity and Inflammation in Subjects With Metabolic Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Metabolic Syndrome
Lead sponsor: Chung Shan Medical University
Sponsor class: OTHER
Collaborators: name: National Science and Technology Council, Taiwan
First posted: 2011-11-02
Enrollment: 54
Sex: ALL
Minimum age (years): 20
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Metabolic syndrome (MS) is a significant risk factor of cardiovascular disease. The purposes of this study are going to investigate the effects of Graptopetalum paraguayense E. Walther on the oxidative stress, antioxidant enzyme activity and inflammation in subjects with metabolic syndromerelation. The investigators will recruit MS patients(n=50)and the inclusion criteria of MS are according to the Bureau of Health Promotion, Department of Health in Taiwan (2007). The MS subjects are randomly assigned to placebo(n=25) and Graptopetalum paraguayense E. Walther supplements(n=25)groups. Hopefully, the results of this study could provide the information of Graptopetalum paraguayense E. Walther supplements to what has been know in MS subjects.


Eligibility criteria: Inclusion Criteria:

* The inclusion criteria of MS in adult are according to the Bureau of Health Promotion, Department of Health in Taiwan (2007), if subjects had 3 of the following 5 characteristics: (1) abdominal obesity (waist circumference \>= 90 cm in men and \>= 80 cm in women), (2) impaired fasting glucose ( \>= 5.6 mmol/L), (3) hypertriglyceridemia ( \>= 1.7 mmol/L), (4) low HDL-C (\< 1.0 mmol/L in men and \< 1.3 mmol/L in women), and (5) increased blood pressure (SBP \>= 130 mmHg and DBP \>= 85 mmHg). Subjects using antidiabetic or antihypertensive or lipid-lowering medications were considered to have elevated fasting blood glucose or elevated blood pressures or dyslipidemia, respectively.

Exclusion Criteria:

* Subjects with liver, renal diseases, undergoing statin therapy, pregnancy women, and taking antioxidant vitamins supplements were excluded.

Primary outcomes:
measure: Antioxidant and inflammation
timeFrame: 12 weeks
Secondary outcomes:
measure: Blood biochemical values
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: Chung Shan Medical University
Study officials:
References:
citation: Yen CH, Chen SJ, Liu JT, Tseng YF, Lin PT. Effects of water extracts of Graptopetalum paraguayense on blood pressure, fasting glucose, and lipid profiles of subjects with metabolic syndrome. Biomed Res Int. 2013;2013:809234. doi: 10.1155/2013/809234. Epub 2013 Nov 25.
Clinical trial NCT01654848: Heparin-induced Thrombocytopenia (HIT II) in Liver Transplant Recipients
Official title: Heparin-induced Thrombocytopenia (HIT II) in Liver Transplant Recipients: a Prospective Multivariate Analysis of Prognostic Factors and Haemostaseological Findings
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Heparin-induced Thrombocytopenia
Liver Transplantation
Keywords: liver transplantation
thrombocytes
heparin-induced thrombocytopenia
multivariate analysis of associated factors of HIT 2 after OLT
laboratory investigations of HIT-antibodies
Lead sponsor: CHIR-Net
Sponsor class: NETWORK
Collaborators: name: University Medicine Greifswald
First posted: 2012-08-01
Enrollment: 39
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: consecutive livertransplant recipients of our transplant center, organ allocation via Eurotransplant Foundation, Leiden, The Netherlands; Laboratory investigations performed at the Abteilung für Transfusionsmedizin am Institut für Immunologie und Transfusionsmedizin der Universitätsmedizin Greifswald, Greifswald, Germany

Brief summary: In a prospective observational study the incidence of Heparin-induced Thrombocytopenia (HIT) Type 2 after orthotopic liver transplantation, associated factors, and hemostaseological findings in thrombocytes and anti-body patterns is going to be investigated.

Detailed description: The investigators examined the frequency of anti-PF4/heparin antibodies (IgG/M/A; EIA) and their functional activity (HIPA) in 38 whole organ deceased donor liver transplant recipients. Additionally, demographic, clinical, donor- and recipient-specific parameters and laboratory findings (ALAT, ASAT, cholinesterase) were investigated.

Eligibility criteria: Inclusion Criteria:

* all consecutive liver transplant recipients between 01/2010 and 08/2011 who
* were transplanted at our center after allocation of a liver graft via Eurotransplant

Exclusion Criteria:

* patient's refusal to participate in prospective observation

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Munich
country: Germany
facility: Klinikum rechts der Isar der TU München
Study officials:
affiliation: Klinikum rechts der Isar, Dept. of Surgery
name: Volker Assfalg, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03171948: Effects of a Limited Almond Consumption After a Weight Loss Plan on Weight Maintenance
Official title: Effects of a Limited Almond Consumption After a Successful Weight Loss by a Comprehensive Weight Loss Plan on Weight Maintenance in Healthy Obese Female Adults: a Randomised Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Overweight
Keywords: almond
weight loss
Weight maintenance
hypoenergetic diet
Lead sponsor: Novindiet Clinic
Sponsor class: OTHER
Collaborators: name: University of Nottingham
name: Tehran University of Medical Sciences
First posted: 2017-05-31
Enrollment: 120
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Almond Group (AG) are asked to have a 30 gr. almond every day in their afternoon snack plus following the hypoenergetic diet Nut Free group (NFG), as control group, who continue their diet without any nut consumption.
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the effects of limited portion of almond consumption after a successful weight loss by a comprehensive weight loss plan (NovinDiet Plan) on weight maintenance in obese female adults.


Eligibility criteria: Inclusion Criteria:

* female
* 18-45 years of age.
* Body mass index (BMI) between 23-30 kg/ m² who lost at least 10% of her initial weight by the diet plan.
* Must be able to have moderate exercise.
* Must be interested to keep weight loss.

Exclusion Criteria:

* No Allergy to nut products
* Pregnancy or lactation during the previous 6 months, or planned pregnancy in the next 6 months.
* Taking medications that could affect metabolism or change body weight.
* Report heart problems, chest pain, and cancer within the last five years.
* Smoking
* Menopause
* Diagnosis of any chronic disease such as fatty liver, cancer, chemo/radio therapy, heart disease, immune compromised conditions, abnormal thyroid hormone level.

Primary outcomes:
measure: weight loss
timeFrame: 6 Month
Secondary outcomes:
measure: Waist circumference
timeFrame: 6 Month
measure: Fasting blood glucose
timeFrame: 6 Month
measure: Fasting insulin level
timeFrame: 6 Month
measure: HbA1c
timeFrame: 6 Month
measure: HOMA-IR
timeFrame: 6 Month
measure: lipid profiles
timeFrame: 6 Month
measure: liver function
timeFrame: 6 Month
Other outcomes:
Locations:
city: Tehran
country: Iran, Islamic Republic of
facility: NovinDiet Clinic
Study officials:
References:
Clinical trial NCT04635748: Feasibility of Collateral Information Review and Its Impact on Clinical Decision-Making
Official title: Feasibility of Collateral Information Review and Its Impact on Clinical Decision-Making
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Depressive Disorder
Anxiety Disorders
Lead sponsor: Mclean Hospital
Sponsor class: OTHER
Collaborators: name: Once Upon a Time Foundation
First posted: 2020-11-19
Enrollment: 89
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: - Clinicians from McLean Hospital Outpatient Programs (geriatric, child and adult) and the McLean Behavioral Health Partial Program, which predominantly treat patients with mood disorders.

Brief summary: This project will investigate how review of collateral information sources (CIS) may impact clinical decision-making across the lifespan.

Detailed description: This study aims to explore how reviewing collateral information sources (CIS) may affect clinical decision-making for clinicians treating participants with varied mood disorders. Investigators will assess the types of collateral information used in the clinical setting and treatment decisions made after a clinical session. We will gather this information from interested clinicians who will provide this information after each patient visit over the course of one week.

Eligibility criteria: Inclusion Criteria:

1. Credentialed to provide psychopharmacology or psychotherapy at McLean and Licensed by the State of Massachusetts
2. Practice pharmacotherapy and either adjunctive or stand-alone evidence-based psychotherapy (e.g., CBT, DBT, supportive psychotherapy, etc.)
3. Fluent in English

Exclusion Criteria:

* Clinicians who do not meet the inclusion criteria detailed above

Primary outcomes:
measure: McLean Treatment Tracking Survey
timeFrame: Over the course of 1 week
Secondary outcomes:
measure: Clinical Outcome - Increased treatment decisions made
timeFrame: Over the course of 1 week
Other outcomes:
Locations:
city: Belmont
country: United States
facility: McLean Hospital
state: Massachusetts
Study officials:
affiliation: Mclean Hospital
name: Ipsit V Vahia, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Mclean Hospital
name: Kerry J Ressler, MD; PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05812248: Prediction of Vascular Events After Major Non-Cardiac Surgery : an Observational Prospective Cohort Study
Official title: Prediction of Vascular Events After Major Non-Cardiac Surgery : an Observational Prospective Cohort Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Noncardiac Surgery
Lead sponsor: Nanfang Hospital, Southern Medical University
Sponsor class: OTHER
First posted: 2023-04-13
Enrollment: 20000
Sex: ALL
Minimum age (years): 45
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients undergoing major noncardiac suregry with medium-to-high risks for postoperative cardiac complications.

Brief summary: This observational study includes patients at medium-to-high cardiovascular risks undergoing major noncardiac surgery, measures their baseline demographic and clinical characteristics, preoperative cardiac biomarkers and intraoperative surgery/anesthesia related data, and screens them for the occurrence of myocardial injury and major adverse cardiac events after surgery. The primary aim is to develop and validate a pre- and an immediate postoperative prediction model for occurrence of major adverse cardiac events.


Eligibility criteria: Inclusion Criteria:

* Age ≥ 45 years;
* Undergoing major noncardiac surgery (expected procedure duration ≥2 h, expected length of postoperative stay ≥2 d);
* History of at least one cardiovascular disease (i.e., coronary artery disease, stroke, congestive heart failure, or peripheral arterial disease) or with at least two cardiovascular risk factors (i.e., hypertension, diabetes, chronic kidney disease, smoking in the past ≥2 years, ≥65 years of age, hypercholesterolemia, history of TIA, high-risk surgery (intrathoracic, intraperitoneal, or major vascular)).

Exclusion Criteria:

* History of acute cardiovascular events within 30 days prior to surgery;
* American Society of Anesthesiologists (ASA) physical status of 5 or greater;
* Previously enrolled in this study;
* Unable to understand or to sign informed consent.

Primary outcomes:
measure: Number of patients with major adverse cardiac event
timeFrame: Within 30 days after the index surgery
Secondary outcomes:
measure: Number of patients with myocardial injury after noncardiac suregry (MINS)
timeFrame: Within 30 days after the index surgery
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Nanfang Hospital, Southern Medical University
state: Guangdong
Study officials:
References:
Clinical trial NCT00000348: Infusion Laboratory: Protocol 4 (Dihydrexidine) - 13
Official title: Infusion Laboratory: Protocol 4 (Dihydrexidine)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Cocaine-Related Disorders
Keywords: cocaine dependence
Lead sponsor: National Institute on Drug Abuse (NIDA)
Sponsor class: NIH
First posted: 1999-09-21
Enrollment: 0
Sex: ALL
Minimum age (years): 21
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate safety issues pertaining to dihydrexidine (DHX), to cocaine, and to its interaction, and to determine how pretreatment with DHX modifies the subjective as well as physiological effects of cocaine infusion.


Eligibility criteria: Inclusion Criteria:

M/F, ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the study and sign informed consent.

Exclusion Criteria:

Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical condtions that deem participation to be unsafe.

Primary outcomes:
measure: Degree of drug craving
measure: Frequency of IV drug use and sexual risk behaviors
measure: History, incidence and amount of drug use
measure: Type and severity of stimulant withdrawal symptoms
measure: Characterization of study population
measure: Population incidence of symptoms of depression, po
measure: Evidence of change in neurophysiology and brain ac
measure: Evidence of change in subjective responses to coca
measure: Clinical physiological response to cocaine challen
measure: Degree to which study medication influences change
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: Friends Research Institute
state: California
Study officials:
affiliation: Friends Research Institute, Inc.
name: Walter Ling, M.D.
role: PRINCIPAL_INVESTIGATOR
References: