Clinical trial NCT02077530: Metabolic Syndrome Cohort in Korea
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Metabolic Syndrome
Keywords: Patients with metabolic syndrome age between 30 to 64: Central obesity (Men ≥ 90 cm Women ≥ 85 cm), Plasma triglycerides ≥ 150 mg/dL
HDL cholesterol Men < 40 mg/dL, Women < 50 mg/dL, Blood pressure ≥130/85 mm Hg (or treatment for hypertension),
Fasting plasma glucose ≥ 100 mg/dL
Lead sponsor: Korea University Anam Hospital
Sponsor class: OTHER
First posted: 2014-03-04
Enrollment: 0
Sex: ALL
Minimum age (years): 30
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with metabolic syndrome living in Seoul area

Brief summary: Patients with metabolic syndrome living in Seoul area are included in this prospective registry for more than 10 years. All enrolled patients undergo thorough medical history survey. Enrolled patients will have coronary CT, 2D echocardiogram, treadmill test, pulse wave velocity, augmentation index, carotid intima-media thickness, and abdominal fat mass evaluation. Moreover, lipid profiles and inflammatory markers such as hsCRP, IL-6, TNF-alpha, VCAM-1, ICAM-1, adiponectin, MMP-9 will be measured. All participants will repeat the test and survey every year in Korea University Hospital.


Eligibility criteria: Inclusion Criteria: 3 out of 5 criteria

* Central obesity: Men ≥ 90 cm Women ≥ 85 cm
* Plasma triglycerides ≥ 150 mg/dL
* HDL cholesterol Men \< 40 mg/dL, Women \< 50 mg/dL
* Blood pressure ≥130/85 mm Hg (or treatment for hypertension)
* Fasting plasma glucose ≥ 100 mg/dL
* Age between 30 to 64
* Consent to our registry protocol

Exclusion Criteria:

* Patients who could not undergo coronary CT, 2D echocardiogram, treadmill test, and pulse wave velocity.

Primary outcomes:
measure: Cardiovascular events
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital Metabolic Syndrome Research Center
Study officials:
References:
citation: Cho DH, Kim MN, Joo HJ, Shim WJ, Lim DS, Park SM. Visceral obesity, but not central obesity, is associated with cardiac remodeling in subjects with suspected metabolic syndrome. Nutr Metab Cardiovasc Dis. 2019 Apr;29(4):360-366. doi: 10.1016/j.numecd.2019.01.007. Epub 2019 Jan 29.
citation: Lee D, Joo HJ, Jung HW, Lim DS. Investigating potential mediator between statin and coronary artery calcification. PLoS One. 2018 Sep 18;13(9):e0203702. doi: 10.1371/journal.pone.0203702. eCollection 2018.
citation: Cho DH, Joo HJ, Kim MN, Lim DS, Shim WJ, Park SM. Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndrome. Cardiovasc Diabetol. 2018 Jun 30;17(1):95. doi: 10.1186/s12933-018-0735-7.
citation: Joo HJ, Cho SA, Cho JY, Lee S, Park JH, Yu CW, Hong SJ, Lim DS. Different Relationship Between Physical Activity, Arterial Stiffness, and Metabolic Status in Obese Subjects. J Phys Act Health. 2017 Sep;14(9):716-725. doi: 10.1123/jpah.2016-0595. Epub 2017 May 17.