Clinical trial NCT03812848: Clinical Pharmacist-led Inpatient Anticoagulation Stewardship Program
Official title: Implementation of Clinical Pharmacist-led Inpatient Anticoagulation Stewardship Program in An Egyptian Tertiary Care Hospital
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Deep Vein Thrombosis
Atrial Fibrillation
Mitral Valve Disease
Keywords: anticoagulation
stewardship program
anticoagulants
clinical pharmacist
heparin
warfarin
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2019-01-23
Enrollment: 233
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Intervention model description: Quasi experimental study (separate sample pre-test post-test design)
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study aims at evaluating the implementation of clinical-pharmacist-led anticoagulation stewardship program in Egyptian tertiary hospital to promote a culture of safety around anticoagulants.

Detailed description: One of the high-alert medication categories that may cause significant patient harm if not used correctly is anticoagulants. It is not clear if medication errors are more common with this category in specific compared to other medication categories, but the ramifications of a medication error with the use of anticoagulation agents is without a doubt detrimental to the patient's health and more serious than most of other drug categories.

This prospective study evaluates the impact of implementing an anticoagulation stewardship program, led by clinical pharmacists, on anticoagulation therapy outcomes during patient hospitalization by the percent of medication errors reduction, percent of adverse drug events reduction, and percent of evidence-based guidelines compliance improvement.

Eligibility criteria: Inclusion Criteria:

All hospitalized patients on therapeutic anticoagulant medication during their hospitalization period.

Exclusion Criteria:

1. Patients whose age is less than 18 years old.
2. Patients who were admitted for less than 24 hours for patient on parenteral anticoagulants and less than 48 hours for patient on warfarin.
3. Patients already admitted for bleeding or thrombosis.
4. Malignancy patients.

Primary outcomes:
measure: Percent of medication errors change
timeFrame: one year and half
measure: percent of adverse drug events change
timeFrame: one year and half
measure: Percent of evidence-based guidelines compliance improvement
timeFrame: one year and half
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Pharmacy, Ain Shams University
Study officials:
References:
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