Clinical trial NCT06844591: Effects of Conditioning Exercises and Resistance Interval Training on Post CABG Patients.
Official title: Comparison Between Conditioning Exercises and Resistance Interval Training on Quality of Life, Cardiorespiratory Fitness and Endurance in Post-CABG Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Coronary Artery Disease
Keywords: Coronary Artery Bypass Grafting
Conditioning Therapy
Quality of Life
Resistance Training.
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2025-02-25
Enrollment: 60
Sex: ALL
Minimum age (years): 40
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants will complete a well-tested Performa. Basic parameters will be collected through the outcome measure tool. Group A will be given a Conditioning exercise protocol while the other Group B will be given resistance interval training for 6 weeks. The difference in improvement before and after 6 weeks will be documented and compared.
Primary purpose: TREATMENT

Brief summary: Coronary artery disease (CAD) is a global health challenge influenced by diabetes, hypertension, and psychosocial stress, with women having a higher prevalence of Coronary microvascular disease. Promoting coronary collateral circulation offers an alternative coronary artery disease CAD treatment. Invasive interventions like PCI and CABG aim to enhance coronary flow, restoring blood flow to ischemic myocardium. Post-CABG challenges include depression, anxiety, and factors affecting quality of life. Physiotherapy impacts heart rate variability, with virtual reality physiotherapy reducing both heart rate variability and hospital stay. Cardiac rehabilitation involves lifestyle changes, enhancing functional capacity, and supporting early recovery. Pre-operative respiratory muscle training improves outcomes. Acute high-intensity interval exercise and mild continuous exercise benefit exercise recovery. This research compares conditioning exercises and resistance interval training effects on post-CABG patients' well-being.

Detailed description: The randomized clinical trial will be conducted in physical therapy department at the District Headquarters (DHQ) in Gujranwala, employing a non-probability convenience sampling technique. The study aims to include individuals aged 40-55 years. Participants in phase IV cardiac rehabilitation. Both female and male will be included.Exclusion criteria involve individuals with another clinical trial involving physical protocols. Regular practice of physical exercise of more than 150min per week in last 3 months. Decompensated heart failure. Further exclusions encompass individuals who have had an acute myocardial infarction or cardiac surgery within the last 6 months, severe valvular heart diseases, uncontrolled cardiac arrhythmias, asymmetric septal hypertrophic cardiomyopathy with dynamic obstruction in the outflow pathway, musculoskeletal disorders limiting completion of the exercise program, and impaired cognitive status affecting understanding and adherence to the study protocol. Group A will be given a Conditioning exercise protocol while the other Group B will be given resistance interval training. The difference in improvement before and after 6 weeks will be documented and compared.

Eligibility criteria: Inclusion Criteria:

* age 40-55 years
* post-coronary artery bypass graft (CABG) patients both females and males were included
* New York Heart Association criteria IV
* Hemodynamically stable patient

Exclusion Criteria:

* Fall in New York Heart Association criteria II III;
* Hemoglobin \< 9 g/dL;
* Patients with peripheral or vascular problems of the lower limb,
* Cognitive and/or mental disorders;
* Exercise limiting comorbidities (primarily orthopedic, neurological condition)
* Enrollment in another clinical trial involving physical training protocols.
* Not willing to participate

Primary outcomes:
measure: SF-36 Questionnaire
timeFrame: 6 weeks
measure: 6-minute walk test
timeFrame: 6 weeks
measure: 30-second stand chair
timeFrame: 6 Weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Gujrānwāla
country: Pakistan
facility: Cheema Heart complex, Hospital Gujranwala
state: Punjab
Study officials:
affiliation: Riphah International University
name: Qurat ul Ain
role: PRINCIPAL_INVESTIGATOR
References:
citation: Terada T, Cotie L, Noda T, Vidal-Almela S, O'Neill CD, Reed JL. Effects of High-Intensity Interval Training, Moderate-to-Vigorous Intensity Continuous Training, and Nordic Walking on Functional Fitness in Patients with Coronary Artery Disease. J Cardiopulm Rehabil Prev. 2023 May 1;43(3):224-226. doi: 10.1097/HCR.0000000000000775. Epub 2023 Mar 2. No abstract available.
citation: Kambic T, Bozic Mijovski M, Jug B, Hadzic V, Lainscak M. Anabolic and Inflammatory Response to High- and Low-Load Resistance Training in Patients with Coronary Artery Disease: A Randomized Controlled Trial. J Cardiopulm Rehabil Prev. 2023 Jul 1;43(4):307-309. doi: 10.1097/HCR.0000000000000783. Epub 2023 Mar 6. No abstract available.
citation: McGregor G, Powell R, Begg B, Birkett ST, Nichols S, Ennis S, McGuire S, Prosser J, Fiassam O, Hee SW, Hamborg T, Banerjee P, Hartfiel N, Charles JM, Edwards RT, Drane A, Ali D, Osman F, He H, Lachlan T, Haykowsky MJ, Ingle L, Shave R. High-intensity interval training in cardiac rehabilitation: a multi-centre randomized controlled trial. Eur J Prev Cardiol. 2023 Jul 12;30(9):745-755. doi: 10.1093/eurjpc/zwad039.
citation: Rengo JL, Savage PD, Hirashima F, Leavitt BJ, Ades PA, Toth MJ. Assessment of the Early Disabling Effects of Coronary Artery Bypass Graft Surgery Using Direct Measures of Physical Function. J Cardiopulm Rehabil Prev. 2022 Jan 1;42(1):28-33. doi: 10.1097/HCR.0000000000000587.
citation: Kristiansen J, Sjuretharson T, Grove EL, Rasmussen J, Kristensen SD, Hvas AM, Mohr M. Feasibility and impact of whole-body high-intensity interval training in patients with stable coronary artery disease: a randomised controlled trial. Sci Rep. 2022 Oct 14;12(1):17295. doi: 10.1038/s41598-022-21655-w.