louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06890403: Can Stories Encourage the Elderly to Vaccinate? Combining Viewer-tailored Personal Narrative Videos With Informational Videos to Improve Vaccine Uptake Among Older Adults
Official title: Can Stories Encourage the Elderly to Vaccinate? Combining Viewer-tailored Personal Narrative Videos With Informational Videos to Improve Vaccine Uptake Among Older Adults
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Vaccination
Keywords: vaccine
narrative
communication
videos
Lead sponsor: Johns Hopkins Bloomberg School of Public Health
Sponsor class: OTHER
Collaborators: name: Merck Sharp & Dohme LLC
First posted: 2025-03-24
Enrollment: 6000
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study will compare the use of informational videos only, personal story videos only, and the combination of both, to see which is most effective in increasing vaccination among older adults.


Eligibility criteria: Inclusion Criteria:

* U.S. adults aged 50 and older

Exclusion Criteria:

* Participants who do not complete the survey
* Participants who are unable or refuse to view and listen to videos on the participant's device

Primary outcomes:
measure: Number of participants who receive vaccine
timeFrame: 9-month follow-up
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Johns Hopkins University
name: Daniel Salmon, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05465603: Rationale and Analysis of the Use of ETDNO in the Treatment of PIPJ Flexion Contracture:
Official title: Rationale for the Use of Elastic Tension Digital Neoprene Orthoses in the Treatment of Proximal Interphalangeal Joint Flexion Contracture: Long Term Results
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Flexion Contracture of Proximal Interphalangeal Joint
Joint Deformities, Acquired
Lead sponsor: Hand Therapy Barcelona
Sponsor class: OTHER
First posted: 2022-07-20
Enrollment: 60
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Introduction: Flexion contracture is one of the most frequent complications in finger trauma. The use of orthoses to obtain the best total end range time (TERT) is the most popular method to treat this pathology . Until now, no orthosis applied for longer than 3 weeks had been able to achieve TERT longer than 12 hours.

Purpose of the study: To assess whether the elastic tension digital neoprene orthosis (ETDNO), using a serial dynamic program, can achieve a better result in ROM and TERT than other orthoses described in the literature.

Methods: analysis of outcomes in a sample of 30 patients with PIP joint flexion contracture treated with the ETDNO and serial dynamic program.

Detailed description: In this study the researcher will compare the efect of daily TERT treatment on the proximal interphalangeal joint contracture using an ETDNO. The investigator will treat two different groups one with a dose of from 11 to 13 hours of the ETDNO while the other one is treated with a dose of from 20 to 22 hours of daily TERT with the same device. This treatment will last three weeks and will be evalauted the first day, the he first week and the third week. At the end of the study the researcher will quantify the improvement on both groups to know which dailyTERT dose is the best option.

Eligibility criteria: Inclusion Criteria:

* PIP flexion contracture

Exclusion Criteria:

* more than 6 month of contracture and more than 45º of flexion contracture

Primary outcomes:
measure: Extension improvement
timeFrame: 3 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: Hand Therapy Barcelona
state: Catalonia
Study officials:
affiliation: Hand Therapy Barcelona
name: Vicenç Punsola-Izard
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01871103: The Dorsal Homodigital Island Flap Based on the Dorsal Branch of the Digital Artery: A Review of 171 Cases
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Soft Tissue Defect
Sensory Reconstruction of Digits
Multiple Digital Defects
Keywords: Soft tissue defect
dorsal branch of the digital artery
dorsal branch of the digital nerve
dorsal homodigital island flap
Lead sponsor: The Second Hospital of Tangshan
Sponsor class: OTHER
Collaborators: name: Chinese PLA General Hospital
First posted: 2013-06-06
Enrollment: 173
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Soft tissue reconstruction in the finger continues to evolve. The dorsum of the finger is a reliable flap donor site in reconstructive hand surgery because of its similar quality to the original. The dorsal homodigital island flap can be used as a reliable alternative for reconstructing small to moderate defects of the fingers. In this retrospective study, the investigators would evaluate the efficacy of the technique for tissue reconstruction in different regions of the finger, with an emphasis on sensibility, pain and donor site morbidity.

Detailed description: At final follow-up, sensory restoration of the flap is measured using the static 2-point discrimination test and Semmes-Weinstein monofilament test. We evaluate pain sensations of the reconstructed fingers and donor sites with a visual analog scale. The system consist of a 10 cm line that is grouped into mild (0-3 cm), moderate (4-6 cm) and severe (7-10 cm). Active motion of the joints is measured using a goniometer. The motion arcs of the reconstructed fingers are compared with the opposite side.

Eligibility criteria: Inclusion Criteria:

* the soft tissue defect in one finger or in multiple fingers
* a defect \> 1.5 cm and \< 3 cm in length
* necessity to preserve finger length
* a patient between 15 and 60 years of age

Exclusion Criteria:

* injuries to the dorsum of the finger or to the course of the vascular pedicle that precluded its use as the donor
* a defect≤1.5 cm or ≥3 cm in length
* a soft tissue defect of the thumb

Primary outcomes:
measure: Static 2-point discrimination test
timeFrame: 18 months to 24 months
Secondary outcomes:
measure: Cold intolerance
timeFrame: 18 months to 24 months
Other outcomes:
Locations:
city: Tangshan
country: China
facility: The Second Hospital of Tangshan
state: Hebei
Study officials:
References:
citation: Chen C, Tang P, Zhang X. Sensory reconstruction of a finger pulp defect using a dorsal homodigital island flap. Plast Reconstr Surg. 2012 Nov;130(5):1077-1086. doi: 10.1097/PRS.0b013e318267ef99.
citation: Chen C, Tang P, Zhang X. The dorsal homodigital island flap based on the dorsal branch of the digital artery: a review of 166 cases. Plast Reconstr Surg. 2014 Apr;133(4):519e-529e. doi: 10.1097/PRS.0000000000000016.
Clinical trial NCT03401203: Debulking With Rotational Atherectomy Versus Balloon Angioplasty In Patients With In-stent Restenosis
Official title: A Prospective, Open Label, Multi-center, Dual Arm, Randomized Trial : The ROTA-ISR (Debulking With Rotational Atherectomy Versus Balloon Angioplasty In Patients With In-stent Restenosis) Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Coronary Vessels
Keywords: ISR
ROTA
DEB
PCI
Lead sponsor: Asan Medical Center
Sponsor class: OTHER
Collaborators: name: CardioVascular Research Foundation, Korea
First posted: 2018-01-17
Enrollment: 95
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is to establish the primary hypothesis that debulking with rotational atherectomy (RA) followed by balloon angioplasty (BA) is superior to BA alone for lesion preparation in patients with coronary in-stent restenosis (ISR) regarding angiography-measured in-segment minimal lumen area at 1 year.


Eligibility criteria: Inclusion Criteria:

* Men or women at least 19 years of age
* Subjects with coronary In-stent restenosis planned revascularization
* In-stent restenosis with neointimal hyperplasia evaluated by intravascular imaging
* The patient or guardian agrees to the study protocol and the schedule of clinical follow-up, and provides informed, written consent, as approved by the appropriate Institutional Review Board/Ethical Committee of the respective clinical site.

Exclusion Criteria:

* Complex lesion anatomy that disables rotational atherectomy
* Any clinically significant abnormality identified at the screening visit, physical examination, laboratory tests, or electrocardiogram which, in the judgment of the Investigator, would preclude safe completion of the study.
* Life expectancy \< 1 years for any non-cardiac or cardiac causes
* Unwillingness or inability to comply with the procedures described in this protocol.

Primary outcomes:
measure: In-segment minimal lumen diameter on angiographic
timeFrame: 1 year
Secondary outcomes:
measure: Device success rate
timeFrame: 1 year
measure: Angiographic outcomes immediate after procedure
timeFrame: 1 hour
measure: OCT outcomes immediate after procedure : In-segment and in-stent minimal lumen area
timeFrame: 1 hour
measure: OCT outcomes immediate after procedure : In-segment and in-stent neointimal volume
timeFrame: 1 hour
measure: Angiographic outcomes : In-segment and in-stent late loss, diameter stenosis
timeFrame: 1 year
measure: OCT outcomes : in-segment and in-stent late lumen area, minimal lumen area loss
timeFrame: 1 year
measure: composite event rate
timeFrame: 1 year
Other outcomes:
Locations:
city: Bucheon
country: Korea, Republic of
facility: Soon Chun Hyang University Hospital Bucheon
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Hospital
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
Study officials:
References:
Clinical trial NCT05778903: Maxillary Nerve Blocks in Children - An MRI Study of the Suprazygomatic Approach
Official title: Maxillary Nerve Blocks in Children - An MRI Study of the Suprazygomatic
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Nerve Block
Cleft Palate
Analgesia
Lead sponsor: Oslo University Hospital
Sponsor class: OTHER
First posted: 2023-03-21
Enrollment: 20
Sex: ALL
Minimum age (years): 10
Maximum age (years): 24
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Ultrasound-guided suprazygomatic maxillary nerve block (SMNB) will be performed in paediatric patients with or without the aid of ultrasound guidance. Magnetic resonance imaging (MRI) is used to visualize the spread of the local anaesthetic (LA) spread after suprazygomatic injection and to verify LA contact with the maxillary nerve in the pterygopalatine fossa (PPF).


Eligibility criteria: Inclusion Criteria:

* Paediatric patients scheduled for cleft palate (CP) surgery with SMNB as part of their perioperative pain treatment
* American Society of Anesthesiologists physical status 1 - 2
* Age 10 to 24 months
* Given informed written consent by legal guardian

Exclusion Criteria:

* American Society of Anesthesiologists physical status \> 2
* Patients with cranial deformation
* Patients with concomitant medical treatments or medical conditions interfering with peripheral nerve block treatment
* Patients with concomitant medical treatments or medical conditions interfering with MRI
* Patients that are allergic to bupivacaine or other local anaesthetic agents.

Primary outcomes:
measure: Rate of LA spread into the PPF
timeFrame: day one - within an hour after intervention (peripheral nerve block)
Secondary outcomes:
measure: Rate of LA spread to other anatomical areas and structures
timeFrame: day one - within an hour after intervention (peripheral nerve block)
measure: Rate of hematoma
timeFrame: day one - within an hour after intervention (peripheral nerve block)
measure: Superior-inferior needle angle
timeFrame: day one - immediately after intervention (peripheral nerve block)
measure: Anterior-posterior needle angle
timeFrame: day one - immediately after intervention (peripheral nerve block)
measure: Needle depth
timeFrame: day one - immediately after intervention (peripheral nerve block)
measure: Side effects and adverse events
timeFrame: day one
measure: Postoperative analgesic consumption
timeFrame: day one and day two
measure: MRI time
timeFrame: day one
Other outcomes:
Locations:
city: Oslo
country: Norway
facility: Oslo University Hospital
Study officials:
affiliation: Oslo University Hospital
name: Axel Sauter, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02478203: Intubation on a Paediatric Manikin by Emergency Staff: a Comparison of Airtraq and Glidescope
Official title: Intubation on a Pediatric Manikin by Emergency Medical Staff: a Comparison of Direct Laryngoscopy, Airtraq and Glidescope in Normal, Tongue Edema and Face-to-face Intubation Models
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Difficult Intubation
Keywords: Airtraq
Glidescope
pediatric
face-to-face
Lead sponsor: Kocaeli University
Sponsor class: OTHER
First posted: 2015-06-23
Enrollment: 13
Sex: ALL
Minimum age (years): 2
Maximum age (years): 7
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: DIAGNOSTIC

Brief summary: After Local Human Research Ethics Committee approval, emergency medical staff enrolled in this study. After watching a video about the intubation using Airtraq, Glidescope or direct laryngoscopy, they attempted to intubate a pediatric manikin in three different airway models.

Detailed description: After Local Human Research Ethics Committee approval, emergency medical staff enrolled in this study. After watching a video about the intubation using Airtraq , Glidescope or direct laryngoscopy, they attempted to intubate a pediatric manikin in three different airway models; normal airway, tongue edema and an entrapped model by face-to-face approach. Intubation attempts, insertion and intubation times, success rates, Cormack-Lehane grades and the need for maneuvers of these devices were recorded.

Eligibility criteria: Inclusion Criteria:

* pediatric

Exclusion Criteria:

* adult

Primary outcomes:
measure: intubation time
timeFrame: 120 seconds
Secondary outcomes:
measure: need of maneuvers (mender applied or not)
timeFrame: intraoperative
measure: esophageal intubation (eosophageal intubation occured or not)
timeFrame: intraoperative
measure: intubation attempts (is it increased or not)
timeFrame: intraoperative
measure: cormack-lehane grade (which one improves the cormack- lehane grade)
timeFrame: intraoperative
measure: insertion time
timeFrame: 30 seconds
Other outcomes:
Locations:
city: Kocaeli
country: Turkey
facility: Kocaeli University School of Medicine
Study officials:
affiliation: Anesthesiology and Reanimation
name: Zehra I Arslan
role: STUDY_DIRECTOR
References:
Clinical trial NCT04153903: Integrated Coronary Multicenter Imaging Registry - Extended
Official title: Integrated Coronary Multicenter Imaging Registry - Extended
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Coronary Artery Disease
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2019-11-06
Enrollment: 200
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Coronary artery disease

Brief summary: The coronary images of invasive angiography and optical coherence tomography (or Coronary CT angiography) with FFR(Fractional Flow Reserve) values of the intermediate lesions (50-70% stenosis) will be prospectively registered.


Eligibility criteria: Inclusion Criteria:

1. Patients who underwent coronary CT angiography because of chest pain
2. Patients who need OCT or FFR evaluation because of intermediate lesions according to invasive angiography (diameter stenosis of 50-70%)
3. Age: 20-80 yrs
4. Patients who consent and fully understand the protocol
5. Patients who consent the clinical follow-up
6. Patients who can be followed-up

Exclusion Criteria:

1. Patients who had contrast allergy
2. Patients who had unstable blood pressure needing the vasopressors
3. Patients who had severe left ventricular function (left ventricular ejection fraction\<30%)
4. Chronic kidney disease who had Cr level of greater than 2.0 mg/dl
5. Patients whose expected survival is less than 12 months
6. Patients who had a severe valvular disease

Primary outcomes:
measure: Comparison of computed FFR derived by coronary images and real FFR values
timeFrame: at registration
Secondary outcomes:
measure: Adverse event (Death, acute myocardial infarction)
timeFrame: 2 years after registration
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Division of Cardiology, Cardiovascular Hospital, Yonsei University
Study officials:
References:
Clinical trial NCT04777903: The Relationship Between Pre-pregnancy BMI and Weight Gain and Outcomes in Women With Twin Pregnancy
Official title: The Relationship Between Pre-pregnancy Body Mass Index (BMI) and Pregnancy Weight Gain and Pregnancy Outcomes in Women With Twin Pregnancy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Twin Pregnancy; Body Mass Index; Weight Gain; Pregnancy Outcome
Lead sponsor: Second Affiliated Hospital of Wenzhou Medical University
Sponsor class: OTHER
First posted: 2021-03-02
Enrollment: 250
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The participants include women with twin pregnancy meeting the inclusion criteria

Brief summary: Prepregnancy body mass index (BMI) and gestational weight gain (GWG) have Significant effects on the risk of pregnancy outcomes such as gestational hypertension disease and gestational diabetes mellitus in singleton pregnancies. This paper is to investigate the relationship between pre-pregnancy body mass index (BMI) and weight gain during pregnancy and pregnancy outcomes in women with twin pregnancy.


Eligibility criteria: Inclusion Criteria:

* Age 18 \~ 41 years old;
* The gestational age of the first diagnosed twin pregnancy is ≤10weeks;
* Double chorionic double amniotic sac pregnancy;

Exclusion Criteria:

* with heart disease, liver disease, kidney disease, complications (chronic hypertension, hyperthyroidism, diabetes and others ), genetic diseases, psychological and mental diseases;
* with history of habitual abortion and cervical insufficiency;

Primary outcomes:
measure: the incidence of gestational diabetes mellitus, gestational hypertension and small for gestational age
timeFrame: 35 weeks to 40 weeks gestation
Secondary outcomes:
Other outcomes:
Locations:
city: Wenzhou
country: China
facility: department of obstetrics of Second Affiliated Hospital of Wenzhou Medical University
state: Zhejiang
Study officials:
affiliation: Second Affiliated Hospital of Wenzhou Medical University
name: Ying Hua
role: STUDY_DIRECTOR
References:
Clinical trial NCT05203003: Prospective Evaluation of the Prognostic Impact of Measurable Residual Disease (MRD) Within a Phase III Study Comparing a Fixed Duration Therapy Versus Continuous Therapy With Daratumumab, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma Requiring a First Salvage Treatment.
Official title: Prospective Evaluation of the Prognostic Impact of Measurable Residual Disease (MRD) Within a Phase III Study Comparing a Fixed Duration Therapy Versus Continuous Therapy With Daratumumab, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma Requiring a First Salvage Treatment.
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Multiple Myeloma
Keywords: multiple myeloma
measurable residual disease
daratumumab
lenalidomide
dexamethasone
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2022-01-24
Enrollment: 260
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients who are included in the CONFIRM phase III trial

Brief summary: We propose to conduct an ancillary prospective evaluation of the impact of Dara-Len-Dex discontinuation after 2 years, on the persistence of MRD negativity in patients that were MRD negative at 2 years.


Eligibility criteria: Inclusion Criteria:

* Adult patients (≥ 18 years old) who are included in the CONFIRM phase III trial (ClinicalTrials.gov Identifier: NCT03836014).
* Subject that are still under therapy at 2 years (+/- 3 month) after randomization, either in the fixed duration therapy group or in the continuous therapy group of the CONFIRM protocol
* Subject in complete response at 2 years (+/- 3 month) after randomization.
* Signed informed consent
* Affiliation to a social security system or equivalent

Exclusion Criteria:

* None

Primary outcomes:
measure: Rate of patients that maintain MRD negativity
timeFrame: 3 and 4 years after inclusion
Secondary outcomes:
measure: PFS at 2 years
timeFrame: 2 years
Other outcomes:
Locations:
city: Paris
country: France
facility: Department of Hematology, Hospital Saint Antoine
Study officials:
affiliation: Assistance Publique - Hôpitaux de Paris
name: Mohamad MOHTY, PUPH
role: PRINCIPAL_INVESTIGATOR
References: