louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03180567: Pharmacogentic Screening of Coumarine Based Oral Anticoagulant Using Next Generation Seguencer
Official title: Pharmacogentic Screening of Coumarine Based Oral Anticoagulant Using Next Generation Seguencer
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Thrombosis
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2017-06-08
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: As drug response is a complex trait in the majority of cases using an optimal starting dose for an individual may reduce the time taken to reach a stable INR, and reduce the risk of having either a high INR (with a risk of bleeding) or a low INR (with a risk of thrombosis)

Detailed description: The results of this project will benefit in (1) Identification of novel features or mutation types in warfarin resistance genomes. (2) To determine whether other polymorphisms in noncoding regions or their unique haplotype combinations contribute to the variability in the maintenance dose of warfarin, and (3)personalization of the drug and deciding the correct dose from the start.

Eligibility criteria: Inclusion Criteria:

* Patients with thrombosis and warfarin resistance

Exclusion Criteria:

* less than 18 years

Primary outcomes:
measure: number of patients with genetic polymorphism
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Sherief Abd-Elsalam
state: Tanta
Study officials:
affiliation: Hematology Dept. - Tanta University
name: Amr Gawaly, Consultant
role: PRINCIPAL_INVESTIGATOR
affiliation: Clinical Pathology dept.- Tanta University
name: Said Hammad Abdou, Prof
role: PRINCIPAL_INVESTIGATOR
affiliation: Biology and Genetics- Tanta University
name: Enas Abdul-Raouf, Lecturer
role: STUDY_DIRECTOR
affiliation: Genetics-Damanhour University
name: Abdelaziz Zidane, Lecturer
role: STUDY_CHAIR
References:
Clinical trial NCT05988567: Efficacy Testing of Melon Oil Olive Pressed Candy Products
Official title: Efficacy Testing of Melon Oil Olive Pressed Candy Products
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Skin Condition
Lead sponsor: TCI Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2023-08-14
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: To assess melon and oil olive pressed candy on skin condition improvement


Eligibility criteria: Inclusion Criteria:

* Healthy adults aged above 18 years old
* ITA° value 20°-41°

Exclusion Criteria:

* Involuntary subjects.
* Subjects who have a history of skin diseases such as psoriasis, eczema, atopic dermatitis, severe acne; or suffer from other chronic systemic disease.
* Those with known cosmetic, drug or food allergies.
* Female who is pregnant or nursing or planning to become pregnant during the course of the study.
* Subjects who have taken oral or topical corticosteroids and other anti-inflammatory drugs in the past 1 month.
* Use of any products or drugs that affect skin color such as fruit acid, salicylic acid (such as Hydroquinone preparations) in the past 2 months.
* In the past 3 months, the test site has used retinoic acid preparations or undergone chemical peeling, laser, pulse light and other medical aesthetic therapists
* Subjects who can not avoid long-term sun exposure

Primary outcomes:
measure: The change of skin wrinkles
timeFrame: Change from Baseline skin wrinkles at 12 weeks
measure: The change of skin texture
timeFrame: Change from Baseline skin texture at 12 weeks
measure: The change of skin melanin index
timeFrame: Change from Baseline skin melanin index at 12 weeks
measure: The change of skin erythema index
timeFrame: Change from Baseline skin erythema index at 12 weeks
measure: The change of skin L* value
timeFrame: Change from Baseline L* value at 12 weeks
measure: The change of skin b* value
timeFrame: Change from Baseline b* value at 12 weeks
measure: The change of skin ITA° value
timeFrame: Change from Baseline ITA° value at 12 weeks
measure: The change of skin spots
timeFrame: Change from Baseline skin spots at 12 weeks
measure: The change of skin UV spots
timeFrame: Change from Baseline skin UV spots at 12 weeks
measure: The change of skin brown spots
timeFrame: Change from Baseline skin brown spots at 12 weeks
Secondary outcomes:
measure: The change of TEAC of blood
timeFrame: Change from Baseline TEAC at 12 weeks
measure: The change of SOD of blood
timeFrame: Change from Baseline SOD at 12 weeks
measure: The change of GSH-Px of blood
timeFrame: Change from Baseline GSH-Px at 12 weeks
Other outcomes:
measure: The change of self-assessment skin and hair condition
timeFrame: Change from Baseline skin and hair condition at 12 weeks
Locations:
city: Tainan City
country: Taiwan
facility: Chia Nan University of Pharmacy & Science
Study officials:
affiliation: Chia Nan University of Pharmacy ＆ Science
name: Chia-Hua Liang, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05794867: Ultrasonic Weaning Criteria in Prolonged Ventilation
Official title: Comparative Study Between Use of Ultrasonic Criteria of Weaning Versus the Conventional Criteria of Weaning in Post-traumatic Acute Respiratory Distress Syndrome Patients Who Were Ventilated for a Long Time
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Lead sponsor: King Abdul Aziz Specialist Hospital
Sponsor class: NETWORK
First posted: 2023-04-03
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: It is a prospective double blind study done on total 200 patients. Who were weaned from ventilator after being ventilated for \> one week due to respiratory failure. This respiratory failure was selected in our study to be from severe lung contusion and post-traumatic acute respiratory distress syndrome.

Brief summary: compare and evaluate the effect of use of ultrasonic criteria of weaning versus the conventional ways of weaning in post-traumatic acute respiratory distress syndrome (ARDS) patients who were ventilated for a long time. And compare their effect on the duration of ICU stay.

Detailed description: It is a prospective double blind study done on total 200 patients. Who were weaned from ventilator after being ventilated for \> one week due to respiratory failure. This respiratory failure was selected in our study to be from severe lung contusion and post-traumatic acute respiratory distress syndrome. Patients were randomly allocated in one of two groups each group contain 100 patients. Group A considered control group. Those patients weaned from the ventilator by the conventional criteria of weaning. While group B weaned from the ventilator by the ultrasound criteria of weaning. All patients weaned from both groups followed for six days for signs of failure of weaning ,signs of post-extubation respiratory failure. And number of patients who were re-ventilated and who discharged from ICU in both groups recorded and compared.

Eligibility criteria: Inclusion Criteria:

* adult patients between 18-65 years old,
* with Acute respiratory distress syndrome,
* any ventilated patients for more than one week

Exclusion Criteria:

* young or pediatric patients below 18 years.
* patients older than 65 years
* patients had Chronic Respiratory Disease

Primary outcomes:
measure: The number of patients who had no failure of weaning
timeFrame: 6 days
Secondary outcomes:
measure: The number of patients who discharged early from ICU
timeFrame: 6 days
Other outcomes:
Locations:
city: Ta'if
country: Saudi Arabia
facility: King abd el Aziz specialist hospital
Study officials:
References:
Clinical trial NCT02826967: Feasibility and Effectiveness of Colonic Irrigation
Official title: Feasibility and Effectiveness of Colonic Irrigation as a Non-oral, Same-day Bowel Preparation Option in Patients Undergoing Screening or Surveillance Colonoscopy
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Colonic Irrigation
Keywords: Hydro-San Plus colonic irrigation system
Screening colonoscopy
Lead sponsor: NYU Langone Health
Sponsor class: OTHER
First posted: 2016-07-11
Enrollment: 36
Sex: ALL
Minimum age (years): 50
Maximum age (years): 84
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: This study will allow investigators to determine whether colonic irrigation may allow for a non-oral, same-day alternative to traditional oral bowel prep regimens. This in turn could lead to more persons able to undergo screening colonoscopy for colorectal cancer and thus increased cancer prevention and early detection.

Detailed description: The primary endpoints for this study are:

* Overall quality of bowel cleansing for each of the three segments of the colon (ascending, transverse, and descending) as measured by the Boston Bowel Preparation Score (BBPS), a validated numerical scale for bowel cleanse (0-3 for each colon segment; 0-9 total score) (6).
* Patient satisfaction, as measured by a questionnaire administered by a study investigator via follow-up phone call after completion of the colonic irrigation and subsequent colonoscopy.

Eligibility criteria: Inclusion Criteria:

* Outpatients age 50-84 years old, who require a screening or surveillance colonoscopy
* Ability to give consent

Exclusion Criteria:

* Pregnancy
* History of ulcerative colitis or Crohn's disease
* History of surgical ostomy
* History of colorectal surgery

Primary outcomes:
measure: Overall quality of bowel cleansing for each of the three segments of the colon (ascending, transverse, and descending) as measured by the Boston Bowel Preparation Score (BBPS)
timeFrame: 15 Minutes
measure: Patient satisfaction, as measured by a questionnaire administered by a study investigator via follow-up phone call after completion of the colonic irrigation and subsequent colonoscopy.
timeFrame: 15 Minutes
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: New York University School of Medicine
state: New York
Study officials:
affiliation: New York University Medical School
name: Mark Pochapin, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01324167: Effects of Gene Polymorphisms on Metabolic Features in Clozapine-treated Patients With Schizophrenia
Official title: Effects of Gene Polymorphisms on Metabolic Features in Clozapine-treated Patients With Schizophrenia
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Schizophrenia
Schizoaffective Disorder
Keywords: schizophrenia
schizoaffective disorder
Lead sponsor: Taipei Medical University WanFang Hospital
Sponsor class: OTHER
First posted: 2011-03-28
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: schizophrenia or schizoaffective disorder patients

Brief summary: The investigators would like to know the association of gene polymorphisms and metabolic adversities in clozapine-treated patients with schizophrenia in Taiwan.

Detailed description: The atypical antipsychotics, such as olanzapine, risperidone, quetiapine, and ziprasidone, are effective in treating both the positive and negative symptoms in schizophrenia (Kelleher et al., 2002). However, atypical antipsychotics have been linked to several forms of morbidity, including obesity, hyperlipidemia, and type 2 diabetes mellitus (DM) (Bergman and Ader, 2005; Jin et al., 2004; Melkersson and Dahl, 2004). Compared with the general population, life expectancy in schizophrenic patients is shorter by as much as 20%, attributable to higher rates of suicide, accidental deaths, and natural causes such as cardiovascular disease and DM (Harris and Barraclough, 1998). Several studies have suggested that these metabolic abnormalities may lead to a greater vulnerability to cardiovascular disease and thus may contribute to the excessive mortality among schizophrenic patients.

Eligibility criteria: Inclusion Criteria:

* fulfilled DSM-IV criteria of schizophrenia or schizoaffective disorder
* 18-65 year of age
* receiving clozapine for at least 6 months

Exclusion Criteria:

* diabetes mellitus patients

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Medical University-WanFang Hospital
Study officials:
affiliation: Taipei Medical University WanFang Hospital
name: Chun-Hsin Chen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06210867: Factors Associated With Occluding the Upper Esophagus by Paratracheal Force
Official title: Factors Associated With Occluding the Upper Esophagus by Paratracheal Force
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Intubation Complication
Lead sponsor: SMG-SNU Boramae Medical Center
Sponsor class: OTHER
First posted: 2024-01-18
Enrollment: 180
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The patients were scheduled for general anesthesia without a risk of difficult intubation or a history of head and neck surgery.

Brief summary: We aim to identify anatomical factors that affect upper esophageal occlusion during the application of paratracheal pressure.

Detailed description: Measure the sternomental distance, thyromental distance, neck length, neck circumference, Mallampati score, BMI, Neck motion, inter-incisor gap, thyrosternal distance. And analysis these factors are associated with upper esophageal occlusion or not.

Eligibility criteria: Inclusion Criteria:

* ≥ 19 years old
* schedule for general anesthesia

Exclusion Criteria:

* Limited neck extension
* Abnormality or anomaly, history of surgery in the neck, esophagus, face, upper airway part.
* Who has weak teeth
* Who has pulmonary aspiration risk

Primary outcomes:
measure: Percentage of esophageal occlusion rate
timeFrame: 10 sec
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Jin-Young Hwang
Study officials:
affiliation: SMG-SNU Boramae Medical Center
name: Jin-Young Hwang, MD,PhD
role: STUDY_CHAIR
References:
citation: Warner MA, Warner ME, Weber JG. Clinical significance of pulmonary aspiration during the perioperative period. Anesthesiology. 1993 Jan;78(1):56-62. doi: 10.1097/00000542-199301000-00010.
citation: Lienhart A, Auroy Y, Pequignot F, Benhamou D, Warszawski J, Bovet M, Jougla E. Survey of anesthesia-related mortality in France. Anesthesiology. 2006 Dec;105(6):1087-97. doi: 10.1097/00000542-200612000-00008.
citation: Landreau B, Odin I, Nathan N. [Pulmonary aspiration: epidemiology and risk factors]. Ann Fr Anesth Reanim. 2009 Mar;28(3):206-10. doi: 10.1016/j.annfar.2009.01.020. Epub 2009 Mar 21. French.
citation: Van de Putte P, Vernieuwe L, Jerjir A, Verschueren L, Tacken M, Perlas A. When fasted is not empty: a retrospective cohort study of gastric content in fasted surgical patientsdagger. Br J Anaesth. 2017 Mar 1;118(3):363-371. doi: 10.1093/bja/aew435.
citation: Gautier N, Danklou J, Brichant JF, Lopez AM, Vandepitte C, Kuroda MM, Hadzic A, Gautier PE. The effect of force applied to the left paratracheal oesophagus on air entry into the gastric antrum during positive-pressure ventilation using a facemask. Anaesthesia. 2019 Jan;74(1):22-28. doi: 10.1111/anae.14442. Epub 2018 Oct 4.
Clinical trial NCT00538967: The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm
Official title: The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Aortic Aneurysm, Abdominal
Keywords: Collagenases
MMP
Cathepsins
Doxycycline
Aneurysm
Lead sponsor: Leiden University Medical Center
Sponsor class: OTHER
First posted: 2007-10-03
Enrollment: 60
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The matrix metalloproteinase-9 (MMP-9) is considered to play a central role in abdominal aortic aneurysm (AAA) initiation. Doxycycline has direct MMP-9 inhibiting properties in vitro, and it effectively suppresses AAA development in rodents. Observed inhibition of AAA progression, and contradictory findings in human studies evaluating the effect of doxycycline therapy on aortic wall MMP-9 suggest that the effects of doxycycline extend beyond MMP-9 inhibition, and that the effect may be dose dependent.

Detailed description: In this clinical trial, we evaluated the effect of two weeks of low (50 mg/day), medium (100 mg/day) or high dose (300 mg/day) doxycycline versus no medication in patients undergoing elective AAA repair. The effect of doxycycline treatment on MMP and cysteine proteases, and their respective inhibitors was evaluated in an integrative approach.

Eligibility criteria: Inclusion Criteria:

* Elective open aneurysm repair

Exclusion Criteria:

* Severe kidney and liver dysfunction

Primary outcomes:
measure: Collagenase mRNA and protein expression
timeFrame: 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Leiden
country: Netherlands
facility: Leiden University Medical Center
Study officials:
affiliation: Leiden University Medical Center
name: Jan HN Lindeman, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06993467: Oxygen Delivery During Cardiopulmonary Bypass And Inflammatory Reaction After Cardiac Surgery
Official title: Oxygen Delivery During Cardiopulmonary Bypass And Inflammatory Reaction After Cardiac Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiopulmonary Bypass
Cardiac Surgery
Systemic Inflammatory Response Syndrome (SIRS)
Keywords: cardiopulmonary bypass
oxygen delivery
systemic inflammatory reaction syndrome
cardiac surgery
Lead sponsor: Azienda Ospedaliero, Universitaria Ospedali Riuniti
Sponsor class: OTHER
First posted: 2025-05-28
Enrollment: 908
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adult cardiac surgery patients undergoing elective cardiopulmonary bypass-assisted procedures

Brief summary: Cardiac surgery, especially when involving cardiopulmonary bypass (CPB), has long been associated with a systemic inflammatory response that can lead to a range of complications, from mild symptoms to severe organ dysfunction, and mortality. The exact mechanisms behind this response remain a topic of extensive research, but it's clear that the body's reaction to the extracorporeal circulation, combined with surgical trauma, plays a significant role. Factors such as genomics, age, specific preoperative conditions, and the duration of operations have been associated with significant clinical responses.

A pivotal insight into this response comes from recent genome-wide transcriptional analyses. Perioperative ischemia and ischemia-reperfusion injury (IRI) have been suggested as hub-nodes in a hierarchic structure evaluating the response to cardiac surgery. This suggests that IRI isn't just a side effect of the surgery but might be a central player in the body's inflammatory response. The role of perioperative ischemia and its potential as a significant contributor to the postoperative inflammatory response cannot be understated. This study aims to delve deeper into the role of oxygen delivery and its implications in the systemic inflammatory response post- cardiac surgery.


Eligibility criteria: Inclusion Criteria:

* Adult patients (18-90 years)
* Elective surgery
* CPB-assisted

Exclusion Criteria:

* Age \< 18 or \> 90 years
* Infective endocarditis
* Hypothermia during surgery (\<34°C)
* Emergency surgery

Primary outcomes:
measure: SIRS
timeFrame: 12 hours after surgery
Secondary outcomes:
measure: Composite outcome
timeFrame: Up to 30 days
Other outcomes:
Locations:
city: Bari
country: Italy
facility: Anthea Hospital
state: Italia
city: Bari
country: Italy
facility: Santa Maria Hospital, GVM Care & Research
state: Italia
Study officials:
References:
Clinical trial NCT01487967: Preference and Goal Directed Attention Deficit Hyperactivity Disorder Care- Pilot Study
Official title: Preference and Goal-Directed Primary Care to Minimize Disparities and Improve Outcomes in ADHD
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Attention Deficit Hyperactivity Disorder
Keywords: Attention Deficit Hyperactivity Disorder
ADHD
Preferences
Goals
Decision Making
Lead sponsor: Children's Hospital of Philadelphia
Sponsor class: OTHER
First posted: 2011-12-08
Enrollment: 120
Sex: ALL
Minimum age (years): 6
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This pilot intervention study will test the feasibility and acceptability and explore the outcomes of an urban, primary care-based intervention to measure families' preferences and goals for Attention-Deficit/Hyperactivity Disorder (ADHD) treatment and structure clinical care to reach these goals.

Detailed description: The intervention includes provision of enhanced, culturally appropriate education about ADHD and its treatment, completion of a validated preference and goal instrument, use of this instrument in the ADHD treatment decision-making process, and tracking of preferences and goals over time.

Eligibility criteria: Inclusion Criteria:

* All interested non-trainee clinicians at study sites
* Parents/legal guardians of children age 6-12, in K-6 grade, diagnosed with ADHD.

Exclusion Criteria:

* child diagnosed with autism or a psychotic disorder
* parents non-English speaking
* parents unable to provide consent
* pediatric residents

Primary outcomes:
measure: Feasibility of family recruitment and follow-up
timeFrame: Up to 24 months
Secondary outcomes:
measure: Joint Participation in Decision-Making and Partnership
timeFrame: Baseline
measure: Treatment Acceptability
timeFrame: Baseline, after 3 months, after 6 months
measure: Parent Engagement
timeFrame: Up to 24 months
measure: Treatment Adherence/Receipt
timeFrame: Up to 24 months
measure: Clinical Outcomes
timeFrame: Baseline, after 3 months, after 6 months
measure: Goal Attainment
timeFrame: after 3 months, after 6 months
measure: Acceptability of the intervention to parents and clinicians
timeFrame: Up to 24 months
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Children's Hospital of Philadelphia
state: Pennsylvania
Study officials:
affiliation: Children's Hospital of Philadelphia
name: Alexander G Fiks, MD, MSCE
role: PRINCIPAL_INVESTIGATOR
References: