louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04902430: Evaluation of the Rate of En-masse Retraction in Orthodontic Patients With Maxillary Protrusion
Official title: Evaluation of the Rate of En-masse Retraction in Orthodontic Patients With Maxillary Protrusion Using Friction Versus Frictionless Mechanics: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bimaxillary Protrusion
Keywords: En-masse Retraction
Friction
Fricitionless
Lateral Cephalometric
Rate
Dental Models
Lead sponsor: Future University in Egypt
Sponsor class: OTHER
First posted: 2021-05-26
Enrollment: 30
Sex: ALL
Minimum age (years): 14
Maximum age (years): 24
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: There's a scarcity in literature concerning en-masse retraction and its effect on the rate of tooth movement. The purpose of this study is to determine, In orthodontic patients with maxillary protrusion, which form of mechanics in en-masse retraction offers a faster rate of retraction; Friction or Frictionless Mechanics.

Detailed description: The en-masse technique can be done in one of two ways: through friction or frictionless mechanics. Both are viable options, but, ideally, we want to retract and complete the orthodontic treatment as quickly as possible, in order to decrease the negative effects that may occur during treatment. Which of these mechanics results in a decreased treatment time is still up for debate.

Eligibility criteria: Inclusion Criteria:

* Adults and Adolescent patients (both genders)
* Age range (14-24)
* Patients with maxillary protrusion requiring first premolars extraction (Bimaxillary Protrusion or Class II division 1 cases).
* Patients with fully erupted permanent teeth (not necessarily including the third molar).
* Cases requiring maximum anchorage during retraction.
* Good general and oral health

Exclusion Criteria:

* Patients suffering from any systemic diseases interfering with tooth movement.
* Patients with extracted or missing permanent teeth. (except for third molars).
* Patients with badly decayed teeth.
* Patients with any parafunctional habits (i.e. Bruxism, tongue thrusting, mouth breathing, etc...).
* Patients with previous orthodontic treatment

Primary outcomes:
measure: Retraction Rate
timeFrame: From pre to post retraction (an average of 6 - 8 months)
Secondary outcomes:
measure: Anchorage Loss
timeFrame: From pre to post retraction (an average of 6 - 8 months)
measure: Molar Rotation
timeFrame: From pre to post retraction (an average of 6 - 8 months)
measure: Pain of intervention
timeFrame: From pre to post retraction/intervention (an average of 6 - 8 months)
measure: Anterior teeth torque, extrusion/intrusion
timeFrame: From pre to post retraction (an average of 6 - 8 months)
Other outcomes:
Locations:
city: New Cairo
country: Egypt
facility: Future University in Egypt
state: Cairo
Study officials:
affiliation: Future University in Egypt
name: Yehia Mostafa, Professor and Chairman
role: STUDY_DIRECTOR
References:
Clinical trial NCT07003230: Effect of Vegan Diet on Microbiome and Metabolism
Official title: Effect of Vegan Diet on Microbiome and Metabolism
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Vegan Diet
Lead sponsor: Zhujiang Hospital
Sponsor class: OTHER
First posted: 2025-06-04
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The goal of this interventional study is to investigate how vegan diet affects health in healthy volunteers, Men and women ages 20 - 30 years old. The main questions it aims to answer are:

Change in Microbial community composition and metabolic alterations Changes in plasma metabolic profile. Researchers will compare changes in microbiota and plasma metabolites profile to see the influence of vegan diet in health. In the dietary trial, participants were first assigned to a 2-week omnivorous diet phase, then switched to a 2-week vegetarian diet phase


Eligibility criteria: Inclusion Criteria: healthe Participants, ages 20-30 years old

Exclusion Criteria:

1. Oral antibiotic use or acute/chronic inflammation within the past 3 months;
2. Hormone intake within the past 3 months;
3. Use of any known interfering medications (e.g., insulin, glibenclamide, indomethacin, phentolamine, furosemide, phenytoin sodium, cortisone, etc.) or probiotics within the past month that may affect glucose or lipid metabolism;
4. Smoking or alcohol consumption;
5. Uncontrolled mental disorders (including a history of psychiatric hospitalization);
6. Currently participating in a weight loss or weight management program;
7. Following a special or medically prescribed diet (e.g., for celiac disease);
8. Comorbid cardiac or renal insufficiency;
9. Chronic constipation;
10. Hypertension;
11. Diabetes mellitus.

Primary outcomes:
measure: Gut microbiota composition in twenty participants
timeFrame: 14days，28days
Secondary outcomes:
measure: Metabolomic profile of twenty participants in serum and feces
timeFrame: 14days, 28days
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Zhujiang hospital
state: Guangdong
Study officials:
References:
citation: Link VM, Subramanian P, Cheung F, Han KL, Stacy A, Chi L, Sellers BA, Koroleva G, Courville AB, Mistry S, Burns A, Apps R, Hall KD, Belkaid Y. Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans. Nat Med. 2024 Feb;30(2):560-572. doi: 10.1038/s41591-023-02761-2. Epub 2024 Jan 30.
Clinical trial NCT04556630: Experience of Lock Down Related to the Covid-19 Epidemic and Its Impact on the Project of Parenthood
Official title: Evaluation of the Experience of Lock Down Related to the Covid-19 Epidemic and Its Impact on the Project of Parenthood of the Couples Followed in Assisted Reproduction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Assisted Reproduction
Lead sponsor: University Hospital, Lille
Sponsor class: OTHER
First posted: 2020-09-21
Enrollment: 400
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: couples followed up in Assisted Reproduction and CECOS Nord

Brief summary: Observational, descriptive, cross-sectional, monocentric study, This Study is proposed to all couples followed in Assisted Reproduction and CECOS Nord for whom the protocols were stopped when they entered into confinement related to the Covid-19 epidemic on 13 March 2020.


Eligibility criteria: Inclusion Criteria:

* couples followed up in Assisted Reproduction and CECOS Nord
* the cessation of assistance reproduction protocols related to the Covid-19 outbreak on March 13, 2020.
* acceptance of teleconsultation

Exclusion Criteria:

* Individuals refusing to participate in the study during the teleconsultation with the referring practitioner.

I- ndividuals who do not respond to the questionnaire

Primary outcomes:
measure: Level of anxiety and/or depression of MPA patients (male and female couples) by Hospital Anxiety and Depression Scale (HAD) score.
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Lille
country: France
facility: Hop Calmette Chu Lille
Study officials:
affiliation: University Hospital, Lille
name: Bérengère DUCROCQ, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00374530: Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2
Official title: Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Headache
Migraine
Lead sponsor: Danish Headache Center
Sponsor class: OTHER
First posted: 2006-09-11
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: Before, during and after intravenous administration of PGE2 we score/measure headache, rCBF, blood flow in the middle cerebral artery and diameter of superficial temporal artery and correlate that to known pathophysiology of headache to see if PGE2 is involved in headache pathophysiology.


Eligibility criteria: Inclusion Criteria:

* Healthy volunteers

Exclusion Criteria:

* Primary Headache, headache on the day of the investigation, hypertension, hypotension, pregnant/nursing, daily intake of medication (except oral contraceptives), Cardiovascular or CNS disease, drug/alcohol abuse, psychiatric disease

Primary outcomes:
measure: Headache
Secondary outcomes:
measure: rCBF, blood flow, diameter of STA/RA, HR, BP
Other outcomes:
Locations:
city: Glostrup
country: Denmark
facility: Danish Headache Center
Study officials:
affiliation: Danish Headache Center
name: Troels Wienecke, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03130530: Retrospective Study on Colorectal Robotic Surgery Results Obtained Using a New Robotic Platform
Official title: Retrospective Study on Colorectal Robotic Surgery Results Obtained Using a New Robotic Platform
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Colorectal Surgery
Keywords: robotic
colorectal
surgery
Lead sponsor: Istituto Clinico Humanitas
Sponsor class: OTHER
First posted: 2017-04-26
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients indicated for colorectal surgery using ALF-X Robotic surgery system

Brief summary: The ALF-X (Advanced Laparoscopy through Force reflection) Robotic Surgery System is a medical device that is available for distribution in the EU (European Union) under CE Mark for use in general surgery, thoracic surgery, gynecological surgery and urological surgery. The main research question is to assess, from a retrospective poit of view, the safety and feasibility of this new robotic platform in the colorectal surgery.

Detailed description: The rationale of this study is to investigate the perioperative and the short term perioperative outcomes of this new robotic Platform in minimally invasive colorectal surgery. Tha ALF-X utilizes fully reusable along with haptic feedback and an innovative vision control system.

Eligibility criteria: Inclusion Criteria:

* Patients affected by colorectal disease (benign or malignant) having undergone surgery using ALF-X platform

Exclusion Criteria:

* none

Primary outcomes:
measure: Evaluation adverse events
timeFrame: from the surgery up to 30 days after the surgery
Secondary outcomes:
measure: Duration of hospitalisation
timeFrame: from surgery to hospital discharge, up to 30 days
measure: Duration of surgery
timeFrame: from to the start to the end of the surgery
measure: Setup for surgery - collision rate
timeFrame: from to the start to the end of the surgery
measure: Setup for surgery - reduced mobility
timeFrame: from to the start to the end of the surgery
measure: Adverse events
timeFrame: Up to 30 days post-surgery
Other outcomes:
Locations:
Study officials:
affiliation: Istituto Clinico Humanitas
name: Antonino Spinelli, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02431130: Low-fidelity Simulation to Teach Anesthetists' Non-technical Skills in Rwanda
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: Training Program
Lead sponsor: Dalhousie University
Sponsor class: OTHER
Collaborators: name: Grand Challenges Canada
First posted: 2015-04-30
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT

Brief summary: The goal of this study is to examine whether low-fidelity instructor-driven simulation can provide effective teaching of anesthetists' non-technical skills in a developing world context. Human factors, such as communication, planning, and team working are considered nontechnical skills which contribute greatly to patient safety in "complex hazardous systems" such as aviation, nuclear power industry, and operating rooms. Simulation began in the aviation industry to train pilots in human factors. In the past two decades simulation has been valued in medical education as it allows the learner to rehearse skills in an environment that is similar to the workplace but without the threat of harm to patients. High Fidelity simulators involve computer driven interactive mannequins that recreate an authentic environment. This has been used successfully to teach anesthetists' non-technical skills (ANTS) such as: decision making, team working, task management, and situation awareness. Anesthetists' non-technical skills are particularly important in developing countries where the shortage of supplies, equipment, and qualified personnel can lead to a perilous working environment making team work and communication vital for patient safety. The costs of high fidelity simulation are prohibitive for many developing countries. This study seeks to examine whether low fidelity instructor driven simulation can provide an effective intervention to teach anesthetists' non-technical skills in Rwanda. If found to be effective, this method of training could be applied to other developing countries to improve non-technical skills for anesthesia providers with the goal of making surgery safer.


Eligibility criteria: Inclusion Criteria:

* anesthesia providers (resident or technician) that provides anesthesia for caesarean section

Exclusion Criteria:

* anesthesia providers that do not provide anesthesia for caesarean section

Primary outcomes:
measure: Improvement in overall ANTS score after simulation training
timeFrame: two weeks after training
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01673230: Hemodynamic Indices Predictive of a Beneficial Response to Fluid Expansion in Case of Hemodynamic Failure After Cardiac Surgery With Altered Preoperative Ejection Fraction (LVEF≤45%)
Official title: Hemodynamic Indices Predictive of a Beneficial Response to Fluid Expansion in Case of Hemodynamic Failure After Cardiac Surgery With Altered Preoperative Ejection Fraction (LVEF≤45%): Sensibility and Specificity of Respiratory Variations of Pulse Pressure (∆PP), Photoplethysmography (∆POP), Perfusion Index (PVI), Before and After Fluid Expansion.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ventricular Dysfunction
Lead sponsor: Rennes University Hospital
Sponsor class: OTHER
First posted: 2012-08-27
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Low Cardiac Output Syndrome occurs frequently after cardiac surgery, especially when pre-operative LVEF is altered (LVEF≤45%). The correction of hemodynamic failure requires adapted treatments: fluid expansion and/or inotropic or vasoactive drugs. Predictive indices of a response to fluid challenge may allow an earlier hemodynamic optimization, which has not been showed until now when LVEF is altered.


Eligibility criteria: Inclusion Criteria:

* patients \>18 years old in the immediate post-operative period after cardiac surgery
* ASA 1 - 3
* Pre-operative LVEF≤45%
* Sedated with Ramsay score: 6
* Mechanically ventilated with tidal volume at 8ml/kg, PEEP at 0mmHg, I/Eat 0,5
* With hemodynamic failure: SAP≤90mmHg and/or inotropic or vasoactive drug started in the operating room and/or clinical sign of shock and/or CI ≤2,3l/min/m2
* Affiliation to Health Insurance
* Consent form signed

Exclusion Criteria:

* Cardiac arrhythmia: frequent atrial or ventricular extra systoles, atrial fibrillation
* Intracardiac shunt
* Weight less than 50 kg
* History of central nervous system illness
* Pulmonary oedema (clinical and/or radiological and/or wedge pressure\>18mmHg)
* Right ventricular failure suspected (CVP\> wedge pressure) or diagnosed (trans thoracic and/or transesophageal echocardiography)
* Acute kidney injury with oligoanuria
* Severe post operative bleeding (chest tubes volume of \>200ml/h for 3 hours or more)
* Severe hypoxia (PaO2/FIO2\< 100)
* Administrative control (patient under guardianship or curatorship)

Primary outcomes:
measure: Measure of ∆PP, ∆POP, PVI and Cardiac index (CI)
timeFrame: 2 hours
Secondary outcomes:
measure: Measure of Systolic, diastolic and mean arterial pressure (SAP, DAP, MAP), Central venous pressure (CVP) and wedge pressure.
timeFrame: 2 hours
Other outcomes:
Locations:
city: Rennes
country: France
facility: Rennes University Hospital
state: Brittany
Study officials:
affiliation: Rennes University Hospital
name: patrick guinet
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04127630: MRI STUDY OF THE LPEC
Official title: Evaluation in MRI of the Impact of the Sellick Manoeuvre or Para-tracheal Compression of the Cervical Esophagus on the Displacement of the Laryngeal Mass and the Visualization of the Vocal Cords
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: MRI
Lead sponsor: University of Liege
Sponsor class: OTHER
First posted: 2019-10-15
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults

Brief summary: Cricoid pressure is still considered as a standard of care in order to prevent the gastric regurgitation in full stomach surgery1.

However, this attitude has been challenged in several case reports as oesophageal rupture, difficult intubation, and even failing to occlude the oesophagus. Moreover, in a large prospective randomized study , this maneuver has failed to show a definite benefit2.

The lateral deviation to the left of the oeso deviate to the left side3,4 has led to the description of a new maneuver to compress directly the oesophagus at the low left paratracheal level. This maneuver has been shown to prevent gastric air insuflation during the ventilation.

In the present study, the investigators aim to asses with an magnetic resonance imaging the compressibility of the oesophagus.


Eligibility criteria: Inclusion Criteria:

* Adults Volunteers

Exclusion Criteria:

* Pregnancy
* Claustrophob
* Thyroid goiter

Primary outcomes:
measure: Oesophagus compressibility
timeFrame: End of the MRI
Secondary outcomes:
Other outcomes:
Locations:
city: Liège
country: Belgium
facility: Javillier
Study officials:
References:
Clinical trial NCT01972230: Sevoflurane Protective Effect on Ischemia Reperfusion Injury in Microvascular Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Microvascular Breast Flap in Plastic Surgery
Lead sponsor: Regina Elena Cancer Institute
Sponsor class: OTHER
First posted: 2013-10-30
Enrollment: 128
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aimed to evaluate the possible protective effect of anesthetic technique balanced (BAL) compared to total intravenous anesthetic technique (TIVA-TCI) in ischemia reperfusion injury in microvascular flap in plastic surgery. The investigators will evaluate the viability of the flap using tissue oximetry monitoring and the level of biochemical markers in a circle at the end of the intervention.


Eligibility criteria: Inclusion Criteria:

* age \> 18 yr
* ASA (American Society of Anesthesiology) I-II

Exclusion Criteria:

* Known unusual reaction to anesthetic drugs
* Evaluation of anesthesia increased risk for malignant hyperthermia.
* History of vascular disease.
* History of bleeding diathesis.
* Tabagism

Primary outcomes:
measure: tissutal oximetry average value of the flap measured with INVOS (In Vivo Optical Spectroscopy) system continuously.
timeFrame: 24 hours from the end of intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Rome
country: Italy
facility: Regina Elena Cancer Institute
state: RM
Study officials:
References:
Clinical trial NCT02332330: CD0104 VEST II Post Marketing Surveillance Study
Official title: A Post-market Prospective Study of the VGS VEST (Venous External Support), Supporting Saphenous Vein Grafts for Coronary Bypass Graft Surgery in Patients With Severe Coronary Heart Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Coronary Artery Bypass Surgery
Lead sponsor: Vascular Graft Solutions Ltd.
Sponsor class: INDUSTRY
First posted: 2015-01-06
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study is designed to collect post market data on use of the VEST, particularly on saphenous vein grafts to the right territory of the heart.

Detailed description: The primary objective is to test the early-mid term patency rate of VEST supported Right Coronary Artery (RCA) bypass grafts. The research participants will undergo CABG preparations and CABG procedure routinely as is the standard of care. During the procedure the VEST will be implanted on the vein graft to the Right Coronary Artery according to the IFU. Perioperative care is according to standard of care. Upon discharge patient will be prescribed statins and aspirin for 6 months. Patient will attend a routine clinic visit 4-6 weeks post operatively. The last study visit will occur 3-6 months post operatively. Patients will undergo a noninvasive coronary CT angiography.

Eligibility criteria: Inclusion Criteria:

1. Patient scheduled for on-pump CABG on clinical grounds
2. At least one vein graft bypass indicated for right coronary artery and LIMA indicated for the LAD on clinical grounds
3. Appropriately sized and accessible target coronary arteries, with a minimum diameter of 1.5 mm and adequate vascular bed, as assessed from the pre-operative cardiac angiography.

Exclusion Criteria:

1. Concomitant non-CABG cardiac procedure
2. Prior cardiac surgery
3. Emergency CABG surgery (cardiogenic shock, inotropic pressure support, IABP)
4. Contraindication for on-pump CABG with cardioplegic arrest (e.g. severely calcified aorta)
5. Calcification at the intended anastomotic sites, as assessed upon opening of the chest and before VEST implantation.
6. Prior debilitating stroke less than 1 year before surgery
7. Severe renal dysfunction (Cr\>2.0 mg/dL)
8. Concomitant life-threatening disease likely to limit life expectancy to less than 2 years.

Primary outcomes:
measure: Vein graft patency by CT angiography
timeFrame: 3-6 monthws
measure: MACCE
timeFrame: 3-6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Trier
country: Germany
facility: Krankenhaus der Barmherzigen Bruder
city: Oxford
country: United Kingdom
facility: The John Radcliffe Hospital
Study officials:
affiliation: Oxford University Hospitals NHS Trust
name: David P Taggart, Professor
role: PRINCIPAL_INVESTIGATOR
References: