Clinical trial NCT04463862: COVID - AirPollution
Official title: Air Pollution and COVID-19 Mortality in Geriatric Patients: a Multicenter Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID-19 Confirmed Cases
COVID-19 Mortality
Keywords: Air pollution
COVID-19
Respiratory viral diseases
PM- NO2-Ozone
Lead sponsor: University Hospital, Strasbourg, France
Sponsor class: OTHER
First posted: 2020-07-09
Enrollment: 660
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients admitted in geriatric departments between 2020/01/01 to 2020/06/01

Brief summary: Epidemiological data have related particulate matter (PM), nitrogen dioxide (NO2) and ozone (O3) to COVID-19 morbidity and mortality at the population level. Air pollution may be related to an increase in the COVID-19 severity and lethality through its impact on chronic diseases such as cardiovascular and respiratory diseases and diabetes that are also the main comorbidities associated with COVID-19. Epidemiological studies using individual data are needed to provide more precise estimate of the association between air pollution exposure and COVID-19. In this multicenter prospective study, the investigators will analyze the number of deaths in COVID-19 confirmed cases in geriatric patients according to long-term exposure to air pollution, taking into account confounders such as diabetes, hypertension, age, and BMI. Exposure to air pollution will be estimated as the mean concentration of air pollutants at the residential address during the previous two years. In addition, the investigators will explore the relationship between short-term variations in air pollutants, relative humidity, temperature, UV radiations, pollen and the occurrence of COVID-19.


Eligibility criteria: Inclusion Criteria:

* Patient over 60 years old (or dementia patient over 50 years old)
* Patient hospitalized in a geriatric department over the period from 2020/01/01 to 2020/06/01
* Patient who underwent RT-PCR SARS-CoV-2
* Patient (or trusted person/ legal guardian/curator, if applicable) who has given consent to the re-use of his/her data (patient data) for research purposes

Exclusion Criteria:

None

Primary outcomes:
measure: COVID-19 related-mortality
timeFrame: COVID-19 mortality between 2020/01/01 and 2020/06/01
Secondary outcomes:
measure: COVID-19 confirmed cases
timeFrame: COVID-19 confirmed cases between 2020/01/01 and 2020/06/01
Other outcomes:
Locations:
city: Bruxelles
country: Belgium
facility: Unité de neurologie-gériatrie, Hôpital Erasme, Cliniques Universitaires de Bruxelles
city: Bischwiller
country: France
facility: Unité de soins palliatifs gériatriques, Centre Hospitalier Départemental de Bischwiller
city: La Roche Sur Yon
country: France
facility: Service de Gériatrie, Centre Hospitalier Départemental de Vendée
city: Nantes
country: France
facility: Service de médecine aigüe gériatrique, Hôpital Nord Laennec, Hôpitaux Universitaires de Nantes
city: Paris
country: France
facility: Service de Gériatrie, Hôpitaux Bichat et Bretonnaux, Assistance Publique des Hôpitaux de Paris
city: Reims
country: France
facility: Service de Médecine Interne et Gériatrie, Hôpitaux Universitaires de Reims
city: Strasbourg
country: France
facility: Service de Gériatrie, Hôpital de la Robertsau, Hôpitaux Universitaires de Strasbourg
city: Tours
country: France
facility: Service de médecine gériatrique, Hôpitaux Universitaires de Tours
Study officials:
affiliation: Hôpitaux Universitaires de Strasbourg
name: Frédéric BLANC, MD
role: PRINCIPAL_INVESTIGATOR
References: