Clinical trial NCT05010057: The Effect of New Zealand Blackcurrant (NZBC) Supplementation on Recovery Following Strenuous Exercise
Official title: The Effect of New Zealand Blackcurrant (NZBC) Supplementation on Indices of Muscle Damage Following Strenuous Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Muscle Damage
Keywords: Exercise-induced muscle damage
Recovery
Supplementation
Oxidative stress
Anthocyanin
New Zealand blackcurrant
Lead sponsor: University of Surrey
Sponsor class: OTHER
First posted: 2021-08-18
Enrollment: 27
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomised, parallel design.
Primary purpose: PREVENTION

Brief summary: The study aims to examine the effect of a New Zealand blackcurrant (NZBC) supplement on markers of muscle damage and recovery following strenuous resistance exercise. The investigation will compare responses between an experimental (NZBC capsule, 300 mg/day) and placebo (PLA capsule, 300 mg sugar) group. Participants will attend a screening session where they will consent to the study, complete a pre-activity medical questionnaire and have their height, weight and resting blood pressure measured. If the participants meet the inclusion criteria they will perform a familarisation session on the muscle strength assessment. Participants will be randomized to NZBC or placebo groups, and consume one capsule in the morning (between 6-10 am) for 12 days. This is a double-blinded study, which means that the participant and the study team will not know which group the participants are assigned to until the study is over. On day 8 participants will perform a strenuous bout of upper body resistance exercise on the isokinetic dynamometer (exercise device). Muscle strength and soreness, arm circumference, and elbow range of motion will be measured, and a fasted blood sample will be collected, before and 24, 48, 72 \& 96 hours after the muscle fatigue protocol (on days 9, 10, 11 \& 12). A marker of muscle damage (creatine kinase \[CK\] concentration) will be measured in the blood samples. Participants will also be asked to complete a 6-day dietary record, beginning on day 7 and ending on the final day of testing (day 12).


Eligibility criteria: Inclusion Criteria:

* Males and Females
* 18 - 45 years old
* BMI: 19 - 29.9 kg/m2
* Healthy: no active disease process that could interfere with endpoints measured as determined by medical history

Exclusion Criteria:

* Smoking and tobacco use
* Takes medication \[excluding contraception\]
* BMI ≥ 30 kg/m2
* Hypertensive (diastolic \> 90 and/or systolic blood pressure \> 140 mmHg)
* History of musculoskeletal upper limb injuries
* Performs regular resistance exercise (\> 2 sessions per week)
* Uses dietary supplements that could influence muscle recovery or function (e.g. protein supplements, antioxidants etc)

Primary outcomes:
measure: Change from baseline in creatine kinase (CK) concentration at 72 hours post-exercise
timeFrame: At baseline (pre-exercise) and 72 hours post-exercise.
measure: Change from baseline in creatine kinase (CK) concentration at 96 hours post-exercise
timeFrame: At baseline (pre-exercise) and 96 hours post-exercise..
Secondary outcomes:
measure: Change in maximum voluntary contraction (MVC) from baseline to 96 hours post-exercise
timeFrame: At baseline (pre-exercise) and post-exercise time points (at 0, 24, 48, 72 and 96 hours respectively).
measure: Change in rating of Delayed Onset of Muscle Soreness (DOMS) from baseline to 96 hours post-exercise
timeFrame: At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).
measure: Change in joint range of motion (ROM) from baseline to 96 hours post-exercise
timeFrame: At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).
measure: Change in mid arm circumference (MAC) from baseline to 96 hours post-exercise
timeFrame: At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).
Other outcomes:
Locations:
city: Guildford
country: United Kingdom
facility: Surrey Human Performance Institute
state: Surrey
Study officials:
affiliation: University of Surrey
name: Julie EA Hunt, PhD
role: PRINCIPAL_INVESTIGATOR
References: