Clinical trial NCT06806943: How Avatar Can Enhance Autobiographical Memory of Patients With Substance Use Disorder
Official title: How Avatar Can Enhance Autobiographical Memory of Patients With Substance Use Disorder
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Substance Use Disorder (SUD)
Keywords: autobiographical memory
substance use disorder
Lead sponsor: Le.L.A.T. Lega Lotta Aids E Tossicodipendenza
Sponsor class: OTHER
Collaborators: name: Catholic University of the Sacred Heart
First posted: 2025-02-04
Enrollment: 42
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: within-subject design
Primary purpose: SUPPORTIVE_CARE

Brief summary: The goal of this study is to investigate whether the use of artificial intelligence platforms can promote the retrieval of specific positive autobiographical memories.

Detailed description: The decision to focus on the retrieval of positive autobiographical memories was made for ethical reasons and is not tied to any specific research hypothesis. Specifically, the study aims to assess whether artificial intelligence facilitates the sharing of personal experiences and reflection on autobiographical memories related to substance use disorders, taking into account the potential influence of individual characteristics such as recent mood state, and overall memory functioning.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of substance use disorder
* Admitted to the drug rehabilitation center for at least 3 months
* Aged 18 years or older

Exclusion Criteria:

* Previous neurological pathologies
* Previous cognitive deficits

Primary outcomes:
measure: Change in Specific Autobiographical Memory Recall
timeFrame: During the intervention sessions for both conditions (avatar-based and face-to-face). This outcome directly reflects the study's objective by quantifying the change of AM recall through avatar-based interventions.
Secondary outcomes:
measure: Latency of Autobiographical Memory Recall
timeFrame: During the intervention sessions for both conditions (avatar-based and face-to-face).
measure: Pleasantness of Autobiographical Memories Recalled
timeFrame: During the intervention sessions for both conditions (avatar-based and face-to-face).
measure: Change in Age Memory Recall
timeFrame: During the intervention sessions for both conditions (avatar-based and face-to-face).
Other outcomes:
Locations:
city: Messina
country: Italy
facility: Le.L.A.T. Lega Lotta Aids E Tossicodipendenza
Study officials:
affiliation: Catholic University of the Sacred Heart
name: Fabio Frisone, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Nandrino JL, Gandolphe MC, El Haj M. Autobiographical memory compromise in individuals with alcohol use disorders: Towards implications for psychotherapy research. Drug Alcohol Depend. 2017 Oct 1;179:61-70. doi: 10.1016/j.drugalcdep.2017.06.027. Epub 2017 Jul 21.
citation: Nandrino JL, Gandolphe MC. Characterization of Self-Defining Memories in Individuals with Severe Alcohol Use Disorders After Mid-Term Abstinence: The Impact of the Emotional Valence of Memories. Alcohol Clin Exp Res. 2017 Aug;41(8):1484-1491. doi: 10.1111/acer.13424. Epub 2017 Jun 14.
citation: De Groote C, Cottencin O, Tison P, Triquet C, Nandrino JL. Autobiographical memories cued by self-statements in patients with alcohol use disorder: linking self-conceptions to past events. Memory. 2023 May;31(5):732-746. doi: 10.1080/09658211.2023.2191899. Epub 2023 Mar 22.
citation: Nandrino JL, El Haj M, Torre J, Naye D, Douchet H, Danel T, Cottencin O. Autobiographical Memory Deficits in Alcohol-Dependent Patients with Short- and Long-Term Abstinence. Alcohol Clin Exp Res. 2016 Apr;40(4):865-73. doi: 10.1111/acer.13001. Epub 2016 Mar 17.
citation: Fernandez-Alvarez J, Colombo D, Suso-Ribera C, Chirico A, Serino S, Di Lernia D, Palacios AG, Riva G, Botella C. Using virtual reality to target positive autobiographical memory in individuals with moderate-to-moderately severe depressive symptoms: A single case experimental design. Internet Interv. 2021 May 27;25:100407. doi: 10.1016/j.invent.2021.100407. eCollection 2021 Sep.
citation: Lenormand D, Mentec I, Gaston-Bellegarde A, Orriols E, Piolino P. Decoding episodic autobiographical memory in naturalistic virtual reality. Sci Rep. 2024 Oct 27;14(1):25639. doi: 10.1038/s41598-024-76944-3.
citation: Frisone F, Brizzi G, Riva G. VR-MEM: Harnessing Virtual Reality for Autobiographical Memory Enhancement in High School Settings. Cyberpsychol Behav Soc Netw. 2024 Jan;27(1):91-93. doi: 10.1089/cyber.2023.29300.ceu. Epub 2023 Nov 16. No abstract available.
citation: Frisone F, Calabro G, Rossi C, Riva G. MEM-AV: A VR-Based Approach to Improve Autobiographical Memory Retrieval in Addiction. Cyberpsychol Behav Soc Netw. 2024 May;27(5):353-355. doi: 10.1089/cyber.2024.42624. Epub 2024 May 8. No abstract available.
citation: Pitel AL, Eustache F, Beaunieux H. Component processes of memory in alcoholism: pattern of compromise and neural substrates. Handb Clin Neurol. 2014;125:211-25. doi: 10.1016/B978-0-444-62619-6.00013-6.
citation: Conway MA, Pleydell-Pearce CW. The construction of autobiographical memories in the self-memory system. Psychol Rev. 2000 Apr;107(2):261-88. doi: 10.1037/0033-295x.107.2.261.