louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06891391: Comparison of Dynamic Neuromuscular Stabilization Exercises and Deep Cervical Muscle Exercises on Muscle Fat Infiltration in Individuals With Neck Pain
Official title: Comparison of Dynamic Neuromuscular Stabilization Exercises and Deep Cervical Muscle Exercises on Muscle Fat Infiltration in Individuals With Neck Pain
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Non-specific Neck Pain
Keywords: Dynamic neuromuscular stabilization
Deep neck muscle exercise
Fatty infiltration
Medical resonance imaging
Non-specific neck pain
Lead sponsor: Tokyo Metropolitan University
Sponsor class: OTHER
First posted: 2025-03-24
Enrollment: 42
Sex: ALL
Minimum age (years): 20
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This clinical trial study aims to compare the effects of DNS (Dynamic Neuromuscular Stabilization) exercises and deep cervical muscle exercises on fat infiltration, disability, and posture in individuals with chronic non-specific neck pain. The clinical questions of this study are as follows:

* Can DNS and deep cervical muscle exercises decrease muscle fat infiltration?
* Can DNS and deep cervical muscle exercises improve neck disability?
* Can DNS and deep cervical muscle exercises improve neck posture?

Researchers will compare DNS and deep cervical muscle exercises to people with non-specific neck pain. DNS exercises are hypothesized to significantly reduce fat infiltration and improve neck disability and neck posture compared to deep cervical muscle exercises.

The participants will undergo an MRI scan and clinical assessment, such as NDI (Neck Disability Index) and posture checking, before being randomly divided into two groups. The first group will perform DNS exercises, and the second group will engage in deep cervical muscle exercises. Both sets of exercises will be performed for 16 weeks as part of a daily routine. After the 16-week exercises, the participants will undergo a follow-up MRI, NDI, and posture checking.


Eligibility criteria: Inclusion Criteria:

* Non-specific neck pain condition for three months or more
* Mild to moderate disability ( more than 10% of NDI)
* Mild to moderate pain level(2-8/10 of NRS)

Exclusion Criteria:

* A history of spine surgery or cervical injury
* Participated in a neck exercise program in the past three months
* Upper extremity problems
* Radiating pain, numbness, and weakness of the upper extremities
* A detectable pathological spinal condition
* Metabolic disorders, diabetes, and hypertension Obesity

Primary outcomes:
measure: Change of muscle fat infiltration in the flexor and extensor muscles
timeFrame: 16 weeks
measure: Change of disability level
timeFrame: 16 weeks
measure: Change of posture
timeFrame: 16 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Arakawa
country: Japan
facility: Tokyo Metropolitan University
state: Tokyo
Study officials:
affiliation: Tokyo Metropolitan University
name: Hardianty A.M Abduh, M. Sc
role: STUDY_CHAIR
References:
Clinical trial NCT05371691: A Comparison of the Effectiveness of Two Types of Myofunctional Appliances
Official title: A Comparison of the Effectiveness of Two Types of Myofunctional Appliances: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Tooth Position Anomalies
Keywords: Myofunctional appliance
Myobrace.
Twin-block
Cl II div I malocclusion
Lead sponsor: University of Baghdad
Sponsor class: OTHER
First posted: 2022-05-12
Enrollment: 30
Sex: ALL
Minimum age (years): 8
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A randomized clinical trial is set out to compare the effectiveness of two types of functional appliances in the correction of a Class II malocclusion. (Class II malocclusions are where upper front teeth bite significantly further forward in relation to lower front teeth).

Detailed description: It is a multicenter randomized clinical trial with two arms parallel group. The patients will be randomly divided into two groups, group one: Myobrace appliance will be used while, and group two Twin-block appliances will be used. Cephalometric x-ray will be taken before starting the treatment (T1) and at the end of treatment (T2) at 9 months. The effectiveness of the two appliances will be assessed and measured comparing the difference in the cephalometric X-ray before and after treatment.

Eligibility criteria: Inclusion Criteria:

1. Growing children who need myofunctional appliance.
2. Cl II div. 1 malocclusion.
3. No previous orthodontic or orthopaedic treatments.

Exclusion Criteria:

1. Patients with systemic involvement.
2. Congenital malformations such as cleft lip and palate.
3. Facial deformities.
4. Finger sucking habit will be excluded

Primary outcomes:
measure: Dentoskeletal changes
timeFrame: T1 at the start of treatment and T2 at the end of treatment around 9 months
Secondary outcomes:
measure: Soft tissue changes
timeFrame: T1 at the start of treatment and T2 at the end of treatment around 9 months
measure: Patient satisfaction
timeFrame: At the end of treatment (around 9 months)
Other outcomes:
Locations:
city: Baghdad
country: Iraq
facility: College of Dentistry-University of Baghdad
state: Al-Rusafa
city: Baghdad
country: Iraq
facility: College of Dentisry-University of Baghdad
Study officials:
References:
Clinical trial NCT05785091: the Degree of Forward Head Posture and Hamstring Muscles Tightness
Official title: Correlation Between the Degree of Forward Head Posture and Hamstring Muscles Tightness in Non Specific Neck Pain
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Forward Head Posture
Keywords: hamstring muscles tightness
calf muscles tightness
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-03-27
Enrollment: 122
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: university students

Brief summary: is the degree of forward head posture correlated with the degree of hamstring muscles tightness

Detailed description: I will measure the degree of forward head posture by photogrammetry method and classify the degree according to its severity measuring the hamstring muscles tightness and classify it too according to its severity and calf muscle tightness lumber flexibility and correlate the to the degree of forward the forward head posture and the degree

Eligibility criteria: Inclusion Criteria:

1. Adult participants 18-30 of age
2. Craniovertebral angle \< 490
3. With or without neck pain

   * subjects with mechanical neck pain (in individual with chronic non-specific neck pain)
   * Subjects are not engaged in any sports or athletic routine Neck disability index \>5 points

Exclusion Criteria:

.Prevalence of serious pathology (rheumatoid arthritis, ankylosing spondylitis, malignancy, infection, inflammatory disorders).

Vascular syndrome such as vertebrobasilar insufficiency Cervical spine history of trauma, fracture, congenital anomalies, or surgical intervention .

Progressive neurological deficits .

.History of lumbar and cervical herniated intervertebral disc with spinal stenosis History of neurological (Guillain-Barre, peripheral neuritis) or orthopedic disorders (osteoporosis, osteoarthritis) Moderate or severe scoliosis History of lower extremity fracture and surgery with malunion Leg length discrepancy BMI \<18 or BMI \>29.9

Primary outcomes:
measure: correlation between the degree of forward head posture and hamstring muscles tightness in non specific neck pain
timeFrame: 6 month
Secondary outcomes:
measure: correlation between the degree of forward head posture and hamstring muscles tightness in non specific neck pain
timeFrame: 6 month
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: CairoU
Study officials:
References:
Clinical trial NCT02208791: Effects of the Quadruple Immunosuppression on Peripheral Blood Lymphocytes and Development of Anti-HLA Antibodies in Kidney Transplant
Official title: Evaluation of the Effects of Sirolimus Addition to the Triple Immunosuppression Protocol on Peripheral Blood Lymphocytes and Development of Anti-HLA Antibodies in Sensitized Kidney Transplant Recipients - a Pilot Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Kidney Transplantation
Keywords: Kidney Transplantation
Graft Rejection
Immunossupression
Lead sponsor: University of Sao Paulo General Hospital
Sponsor class: OTHER
First posted: 2014-08-05
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the effects of sirolimus in the phenotype of peripheral blood T and B lymphocytes regarding their naïve, memory, effector end regulatory phenotype and in the development of anti-HLA antibodies among kidney transplant recipients with high immunological risk for graft rejection.


Eligibility criteria: Inclusion Criteria:

* Men and women, ages 18 to 60 years inclusive
* Percentage of Panel Reactive Antibodies at transplantation \> 20%
* Estimated glomerular filtration rate using MDRD formula at inclusion \>29ml/min

Exclusion Criteria:

* Subjects with a history of cancer
* Subjects with a previous non kidney transplantation
* Subjects receiving any immunosuppression different of tacrolimus/prednisone/mycophenolate
* Subjects with a urinary protein/creatinine ratio greater than 0.3
* Subjects with active HBV, HCV and HIV infection

Primary outcomes:
measure: A composite of graft loss and/or death with graft function
timeFrame: up to one year
Secondary outcomes:
measure: Number of participants with serious and non-serious adverse events and the incidence of biopsy proven acute allograft rejection
timeFrame: Up to one year
Other outcomes:
Locations:
city: Sao Paulo
country: Brazil
facility: Hospital das Clinicas - Faculdade de Medicina da Universidade de São Paulo
Study officials:
References:
Clinical trial NCT01686191: Genetic Predictors of Renal Dysfunction Following Heart Transplantation
Official title: Pharmacogenomics of Calcineurin Inhibitor Nephrotoxicity in Cardiac Transplantation
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Heart Transplantation
Chronic Renal Insufficiency
Keywords: heart transplantation
chronic renal insufficiency
pharmacogenomics
cyclosporine
tacrolimus
Lead sponsor: University of Colorado, Denver
Sponsor class: OTHER
Collaborators: name: National Jewish Health
First posted: 2012-09-17
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cardiac transplant clinic

Brief summary: Kidney disease is a common problem after heart transplantation. It may be caused by anti-rejection medications such as cyclosporine or tacrolimus. However, the reason why some people develop kidney problems after a heart transplant, but other people do not, is not fully known. This study plans to learn more about the relationship between a person's genetic make-up (DNA; deoxyribonucleic acid) and the risk of kidney problems after a heart transplant. The long-term goal of this research is to identify genetic variations that may help predict the development of kidney problems after heart transplantation.


Eligibility criteria: Inclusion Criteria:

* cardiac-only transplant
* 18 years of age or older at the time of cardiac transplant
* 1 year or more post-cardiac transplant
* treatment with cyclosporine or tacrolimus following transplant

Exclusion Criteria:

* combined organ transplant
* decisionally impaired
* unable to read or speak English
* unable or unwilling to provide written informed consent

Primary outcomes:
measure: Chronic renal dysfunction
timeFrame: year 2 post-transplant
Secondary outcomes:
Other outcomes:
Locations:
city: Aurora
country: United States
facility: University of Colorado Anschutz Medical Campus
state: Colorado
Study officials:
affiliation: University of Colorado, Denver
name: Christina L Aquilante, Pharm.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02314091: Long Term Results of Randomized Prospective Comparison of Onlay and Sublay Mesh Repair Techniques for Incisional Hernia
Official title: Long Term Results of Randomized Prospective Comparison of Onlay and Sublay Mesh Repair Techniques for Incisional Hernia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Incisional Hernia
Lead sponsor: Konya Meram State Hospital
Sponsor class: OTHER
First posted: 2014-12-10
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Randomised prospective comparison of onlay and sublay mesh repair techniques in incisional hernia


Eligibility criteria: Inclusion Criteria:

* Incisional hernia
* Acceptance of the trial

Exclusion Criteria:

* BMI\>40
* ASA score of 4
* Severe pulmonary or cardiac disease

Primary outcomes:
measure: recurrence
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Konya
country: Turkey
facility: Konya Training and Research Hospital
Study officials:
References:
Clinical trial NCT04195191: Intervention to Improve the Adherence in Community Pharmacies
Official title: Effectiveness of an Intervention to Improve the Adherence to Treatment of New Medicines From the Community Pharmacy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Chronic Obstructive Pulmonary Disease (COPD
Arterial Hypertension
Diabetes Mellitus
Lead sponsor: Andalusian School of Public Health
Sponsor class: OTHER_GOV
First posted: 2019-12-11
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: cluster randomized controlled trial.
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The ANM is the first initiative that puts advanced pharmaceutical care into practice in Andalusia (Spain). The aim of this is study is to evaluate the effectiveness of the intervention Assistance to New Medicines (ANM) in the improvement of adherence to treatment in community pharmacies.

Detailed description: Design: parallel cluster pragmatic randomized controlled trial. The study includes patients users of a community pharmacies, who meet the following inclusion criteria: patient who starts treatment of any of the following pathologies: Chronic Obstructive Pulmonary Disease (COPD), Arterial Hypertension or Diabetes Mellitus in Andalusia (Spain).

In order to avoid possible contamination between patients assigned to the control and intervention group, randomization will be carried out at the pharmacy level; preventing the pharmacist from applying part of the intervention to the control group.

Interventions: patients randomized: (i) current practice; or (ii) ANM intervention thru a pharmacist delivered support for a newly prescribed medicine.

Eligibility criteria: Inclusion Criteria: patient who starts treatment of any of the following diseases:

* Chronic Obstructive Pulmonary Disease (COPD).
* Arterial Hypertension
* Diabetes Mellitus.
* Anticoagulants

Exclusion Criteria:

* those users who do not know how to read and write in Spanish,
* Suffer from a physical or mental disorder that makes it impossible to perform the

Primary outcomes:
measure: Adherence to treatment
timeFrame: Ten weeks
measure: Adherence to treatment
timeFrame: Six months
Secondary outcomes:
measure: Satisfaction with the service
timeFrame: Ten weeks and six months
Other outcomes:
Locations:
city: Granada
country: Spain
facility: Andalusian School of Public Health & CIBER en Epidemiología y Salud Pública (CIBERESP).
Study officials:
References:
Clinical trial NCT01449591: Safety, Tolerability and Efficacy of BFH772 in Rosacea Patients
Official title: A Proof of Concept (PoC) Study to Evaluate the Safety, Tolerability, and Efficacy of 12 Week Administration of BFH772 Ointment in Rosacea Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Erythemato-telangiectatic Rosacea
Keywords: BFH772
rosacea
erythemato-telangiectatic rosacea
Lead sponsor: Novartis
Sponsor class: INDUSTRY
First posted: 2011-10-10
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will evaluate the safety, tolerability and efficacy of BFH772 after 12 weeks of treatment as compared to an active control and vehicle in patients with erythemato-telangiectatic rosacea.


Eligibility criteria: Inclusion Criteria:

* Have persistent facial erythema on the cheeks of at least moderate severity.
* Women must not be able to bear children

Exclusion Criteria:

* Have more than 12 inflammatory lesions on the face
* Previous treatment of facial skin with lasers or electrocauterisation within 2 months prior to entering the study
* Have facial hair that makes it difficult to evaluate rosacea on the face Other protocol-defined inclusion/exclusion criteria may apply

Primary outcomes:
measure: To assess the effect of BFH772 treatment compared to vehicle on non-transient facial erythema using the Investigator's assessment of facial erythema score
timeFrame: 12 weeks
Secondary outcomes:
measure: To evaluate a patient's assessment of flushing frequency via patient reported episodes and facial redness via a patient reported score
timeFrame: 12 weeks
measure: To measure blood levels of BFH772 in patients
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Hot Springs
country: United States
facility: Novartis Investigative Site
state: Arkansas
city: Ann Arbor
country: United States
facility: Novartis Investigative Site
state: Michigan
city: Paramus
country: United States
facility: Novartis Investigative Site
state: New Jersey
city: Portland
country: United States
facility: Novartis Investigative Site
state: Oregon
city: Austin
country: United States
facility: Novartis Investigative Site
state: Texas
city: Spokane
country: United States
facility: Novartis Investigative Site
state: Washington
Study officials:
affiliation: Novartis Pharmaceuticals
name: Novartis Pharmaceuticals
role: STUDY_DIRECTOR
References:
Clinical trial NCT02529891: Identification of Volatile Organic Compounds in Exhaled Air During Exacerbation of Chronic Obstructive Pulmonary Disease
Official title: Identification of Volatile Organic Compounds in Exhaled Air During Exacerbation of Chronic Obstructive Pulmonary Disease
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Keywords: Chronic Obstructive Pulmonary Disease
COPD
Volatile Organic Compounds
Exacerbation
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
Collaborators: name: Aide à la Recherche Médicale Ondaine et Environs
First posted: 2015-08-20
Enrollment: 19
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with exacerbation of COPD and Healthy volonteers

Brief summary: Exacerbations of the disease are a hallmark of Chronic Obstructive Pulmonary Disease (COPD), affecting the decline of pulmonary function, quality of life and increasing morbidity. The use of validated biomarkers could help to identify the etiology of exacerbation and to prescribe antibiotherapy when indicated.

The analysis of exhaled air allows measuring different volatile organic compounds (VOC) which reflect local or systemic inflammation and oxidative stress. The relationship between the presence of some of these compounds and the exacerbation of COPD has never been studied.

The aim of this study is to identify a cluster of VOC in COPD patients during an acute exacerbation of the disease, compared to a stable condition (3 months after discharge). Investigators also will seek for a relationship between VOC and the etiology of exacerbation (bacterial, viral, inflammatory).


Eligibility criteria: Inclusion Criteria of COPD group:

* COPD stages 2 and 3 of GOLD score (30 ≤ forced expiratory volume at one second (FEV1) \< 80% of predicted value),
* exacerbation confirmed clinically (increased dyspnea, cough or expectorations \> 48 hours)

Inclusion Criteria of non COPD group:

* No smoker (\<100 cigarettes/year)

Exclusion Criteria of COPD group:

* Diagnosis of COPD not confirmed.
* Instable clinical status with respiratory failure and indication of mechanical ventilation.
* Bronchodilator treatment changed
* Antibiotic treatment started in the 10 last days before admission

Exclusion Criteria of non COPD group:

* Chronic inflammatory disease
* Any respiratory disease
* Oral corticosteroid treatment during the last month

Primary outcomes:
measure: Spectrum of VOC measured with a portable mass spectrometer system
timeFrame: Day 1 (within 48 hours after hospital admission for exacerbation of COPD)
Secondary outcomes:
measure: Variation in VOC spectrum in COPD patients measured with a portable mass spectrometer system
timeFrame: 3 months after hospital discharge
Other outcomes:
Locations:
city: Saint-etienne
country: France
facility: CHU de SAINT-ETIENNE
Study officials:
affiliation: CHU de SAINT-ETIENNE
name: Frederic COSTES, MD PhD
role: PRINCIPAL_INVESTIGATOR
References: