Clinical trial NCT00590291: Molecular Determinants of Coronaruy Artery Disease
Official title: Genetic Studies of Coronary Artery Disease and Arteriovenous Malformation (GeneQuest) Molecular Determinants of Coronary Artery Disease
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Coronary Artery Disease
Arteriovenous Malformations
Myocardial Infarction
Keywords: Coronary Artery Disease
Arteriovenous Malformations
Myocardial Infarction
CAD
MI
Heart Attack
AVM
genetic
familial
Lead sponsor: The Cleveland Clinic
Sponsor class: OTHER
Collaborators: name: National Heart, Lung, and Blood Institute (NHLBI)
First posted: 2008-01-10
Enrollment: 1461
Sex: ALL
Minimum age (years): 45
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: FAMILY_BASED
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with CAD or AVM and their family members and 500 normal control individuals The total number enrolled is 2,980, and approximately 2,000 recruited at the Cleveland Clinic.

We will comply with the NIH guidelines by including women and members of minority groups and their subpopulations in the study.

Brief summary: The purpose of this study is to discover genes that may cause Coronary Artery Disease (CAD) or Arteriovenous Malformation (AVM).

Detailed description: The purpose of this study is to discover genes that may cause Coronary Artery Disease (CAD) or Arteriovenous Malformation (AVM). Many human diseases are inherited or passed from parent to child in families. These diseases occur because of damage to a gene(s), the genetic material that is also called DNA. Scientists can now use modern molecular techniques to locate and to find certain genes within the DNA (genetic material) of a person, and to follow their inheritance in a family. To find these disease-causing genes requires studies of many affected with the disease and their family members. The purpose of this study is to locate and to find the genes for coronary artery disease (CAD) which occurs when one or more of the arteries that carry oxygen-rich blood from your heart to the rest of your body develop blockages; or, arteriovenous malformation (AVM) which causes abnormal vascular connections between arteries and veins, particularly near the heart. Findings of the genes causing CAD and AVM will have far-reaching effect on the diagnosis, treatment, and prevention of coronary artery disease and arteriovenous malformation. These studies will lead to possible genetic diagnosis, early detection of persons at risk for developing CAD or AVM (even in the absence of symptoms), development of effective drugs, more rational and specific therapeutic interventions, treatments and ultimately, prevention of coronary heart disease. Approximately 3-5 years are required to find one human disease gene.

Eligibility criteria: Inclusion Criteria:

* Males at least 45 years old and premenopausal females at least 50 years old at the time of onset of any of the following:
* PTCA
* MI
* CABG
* Must have a living sibling meeting the same criteria.

Exclusion Criteria:

* Substance Abuse in the absence of angiographic coronary stenosis
* Congenital Heart Disease

Primary outcomes:
measure: Coronary Artery Disease
timeFrame: 2009
measure: Arteriovenous Malformation
timeFrame: 2009
Secondary outcomes:
measure: Myocardial Infarction
timeFrame: 2009
Other outcomes:
Locations:
city: Cleveland
country: United States
facility: Cleveland Clinic
state: Ohio
Study officials:
affiliation: The Cleveland Clinic
name: John Barnard, PhD
role: PRINCIPAL_INVESTIGATOR
References: