Clinical trial NCT01198730: Screen of DM by OGTT in Subjects Receiving CAG or MDCT for CAD
Official title: Screen of Diabetes Mellitus by Oral Glucose Tolerance Test in Subjects Receiving Catheterization or Multi-detector Computed Tomography (MDCT) for Coronary Artery Disease
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Diabetes Mellitus
Coronary Artery Disease
Keywords: DM
CAD
Meal tolerance test
Lead sponsor: Taichung Veterans General Hospital
Sponsor class: OTHER
First posted: 2010-09-10
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: In this prospective observational study, we screened adult patients admitted for coronary angiography due to angina

Brief summary: To determine the glucose regulation status of patients who were suspected to have CAD in central Taiwan.

Detailed description: It had been reported that high prevalence of IGT (impaired glucose tolerance) and unknown DM (diabetes mellitus) in patients with CAD (coronary artery disease). This study aimed to determine the glucose regulation status of patients who were suspected to have CAD in central Taiwan. In general, patient who were admitted for CAG (coronary angiography) or MDCT without known DM were eligible. After informed consent, OGTT (oral glucose tolerance test) was performed to determine the glucose regulation status. Study participants will be requested to complete questionnaires to assess their risk of diabetes and quality of sleep. Patients who were diagnosed as new DM would be asked to follow up in clinical service with diet control.

Eligibility criteria: Inclusion Criteria:

* Patient received CAG or MDCT for suspect CAD
* Without DM history

Exclusion Criteria:

* Known DM
* Unstable disease condition
* Pregnancy

Primary outcomes:
measure: Diabetes
timeFrame: 3 months
Secondary outcomes:
measure: Brain-derived neurotrophic factor
timeFrame: 3 months
measure: Coroanry artery disease
timeFrame: 3 months
measure: Mortality
timeFrame: 5 years
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
Study officials:
affiliation: Taichung Veterans General Hospital
name: Wayne H-H Sheu, MD, PHD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Liang KW, Lee WJ, Lee IT, Lee WL, Wang JS, Wu JP, Sheu WH. Subjects with microvascular angina have longer GT repeats polymorphism in the haem oxygenase-1 gene promoter. Biomarkers. 2020 Mar;25(2):144-148. doi: 10.1080/1354750X.2020.1713214. Epub 2020 Jan 20.
citation: Liang KW, Sheu WH, Lee WJ, Lee WL, Fu CP, Wang JS. Differential expression of circulating vascular cell adhesion molecule-1 in subjects with coronary artery disease and cardiac syndrome X without known diabetes mellitus. Biomarkers. 2017 Dec;22(8):798-804. doi: 10.1080/1354750X.2017.1351003. Epub 2017 Jul 18.
citation: Liang KW, Sheu WH, Lee WJ, Lee WL, Pan HC, Lee IT, Wang JS. Post-challenge insulin concentration is useful for differentiating between coronary artery disease and cardiac syndrome X in subjects without known diabetes mellitus. Diabetol Metab Syndr. 2017 Feb 8;9:10. doi: 10.1186/s13098-017-0209-1. eCollection 2017.
citation: Wang JS, Lee IT, Lee WJ, Lin SY, Fu CP, Ting CT, Lee WL, Liang KW, Sheu WH. Performance of HbA1c and fasting plasma glucose in screening for diabetes in patients undergoing coronary angiography. Diabetes Care. 2013 May;36(5):1138-40. doi: 10.2337/dc12-1434. Epub 2012 Dec 13.