Clinical trial NCT06606704: Effects of Resistance-band Training and Creatine Supplementation Strategies in Healthy Older Adults
Official title: Effects of Resistance-band Training and Creatine Supplementation in Healthy Older Adults
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Aging
Keywords: Aging
Creatine
Resistance-Bands
Muscle
Strength
Lead sponsor: University of Regina
Sponsor class: OTHER
Collaborators: name: Iovate Health Sciences International Inc
First posted: 2024-09-23
Enrollment: 52
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary purpose is to compare the effects of creatine supplementation (bolus ingestion of 5 grams vs. 3 grams) during 16 weeks of resistance-band training on measures of body composition (i.e., whole-body lean tissue mass, total body water), arm and leg muscle thickness (growth), muscle performance (i.e., power, strength, endurance) and functional ability (i.e., walking speed, balance).

A secondary purpose of this research is to examine the effects of bolus ingestion of creatine (5 grams) compared to intermittent ingestion of creatine (2 x 2.5 grams) during 16 weeks of resistance-band training on measures of body composition (i.e., whole-body lean tissue mass, total body water), arm and leg muscle thickness (growth), muscle performance (i.e., power, strength, endurance) and functional ability (i.e., walking speed, balance).

Detailed description: Resistance-band training is safe, conveient, easy-to-use, eliminates potential barriers to exercise participation (i.e., lack of transportation to and from commercial training facilities) and results in high exercise compliance and adherence. Further, resistance-band training results in similar improvements in muscle performance and functional ability compared to traditional resistance-type training using free-weights and machines.

Creatine is a naturally occurring nitrogen-containing compound produced in the body in the liver and brain and can also be found in food products such as red meat and seafood or through commercially available manufactured creatine products.

Evidence-based research shows that creatine supplementation, when ingested during a resistance exercise training program, improves measures of lean mass and muscle growth, muscle performance and functional ability. However, the optimal creatine supplementation protocol to achieve these benefits is unknown.

Eligibility criteria: Inclusion Criteria:

* if you are 50 years of age and older
* if you have not been performing more than 1 resistance training session per week for the past 6 weeks or more.

Exclusion Criteria:

* if you have taken creatine supplements within 30 days prior to the start of the study
* if you have pre-existing allergies to the placebo (corn-starch maltodextrin).

Primary outcomes:
measure: Whole-body lean mass (kg)
timeFrame: baseline, week 16
measure: Muscle Hypertrophy (cm)
timeFrame: baseline, week 16
measure: Strength (kg)
timeFrame: baseline, week 16
measure: Endurance (number of repetitions to fatigue)
timeFrame: baseline, week 16
measure: Power (feet)
timeFrame: baseline, week 16
measure: Balance (Centre of Pressure)
timeFrame: baseline, week 16
measure: Gait Speed (meters)
timeFrame: baseline, week 16
Secondary outcomes:
Other outcomes:
Locations:
city: Regina
country: Canada
facility: University of Regina
state: Saskatchewan
Study officials:
affiliation: University of Regina
name: Darren Candow
role: PRINCIPAL_INVESTIGATOR
References: