Clinical trial NCT02498730: Interval Training in Bipolar Disorder
Official title: Can the High Intensity Interval Training (HIIT) Deliver Superior and Rapid Decrease of Symptoms of Bipolar Disorder? a Controlled and Randomized Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bipolar Disorder
Keywords: bipolar disorder
VO2max
aerobic exercise
Lead sponsor: Universidade Federal do Rio de Janeiro
Sponsor class: OTHER
First posted: 2015-07-15
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Maximum age (years): 59
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized Controlled Trial
Primary purpose: TREATMENT

Brief summary: Our main objective will be to evaluate the chronic effects (12 weeks) of high-intensity interval training compared to moderate intensity (same total work) on reducing the symptoms of bipolar disorder, cortical changes, as well as on the VO2max. In addition, the investigators will establish what influence of gain to VO2max has on reducing symptoms.

Detailed description: Physical exercise has significant effects on health promotion and the consequent reduction of the severity of bipolar disorder (BD). This review establishes a pattern of response of exercise and potential impact on the pathophysiology of BD; , as well as, produces hypotheses on how acute and chronic effect of exercises may act differently; and provides future perspectives with the focus of the exercise as an important and innovative model of treatment for BD and mental disorder. A critical evaluation of the literature was undertaken including the influence of exercise on health promotion in patients with mental disorders, neurochemical behavior exercise-induced, as well as reflective introduction of news perspectives of training control in severe exercise domain. The exercise induces significant changes in monoaminergic after, and with long-term training, and work with a threshold of exercise can modulate positive effects on mood. Fast adaptive effects from the high intensity interval training should be considered in BD patients. However, there must be caution in his administration. We speculate that exercise may be a way of maintaining euthymia in the case of BD, making it less vulnerable patient to stay longer at a time of neutrality. Future research is needed to adopt a training strategy that is both time efficient in the different areas and adequate for the population in question.

Eligibility criteria: Inclusion Criteria:

* Bipolar Criteria (DSM-IV),
* sedentary lifestyle

Exclusion Criteria:

* 60 and over,
* Cardiovascular Disease,
* Panic disorder,
* Metabolic syndrome Diagnosis

Primary outcomes:
measure: Symptom Scales (Hamilton and Young)
timeFrame: 0 week, 6 week, 12 week
Secondary outcomes:
measure: Cortical Changes (EEG) - Loreta
timeFrame: 0 week, 6 week, 12 week
measure: VO2Max
timeFrame: 0 week, 6 week, 12 week
measure: Cognitive Function
timeFrame: 0 week, 6 week, 12 week
Other outcomes:
Locations:
city: Rio de Janeiro
country: Brazil
facility: Institute of Psychiatry (IPUB)
Study officials:
affiliation: Universidade Federal do Rio de Janeiro
name: Sérgio E. Machado, PhD
role: STUDY_DIRECTOR
References: