Clinical trial NCT04959357: The Evaluation of Left Ventricular Systolic Function in Different Types of Ischemic Heart Disease
Official title: The Evaluation of Left Ventricular Systolic Function in Different Types of Ischemic Heart Disease by Two-dimensional Speckle-tracking Echocardiography
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronary Microvascular Dysfunction
Obstructive Coronary Heart Disease
Keywords: two-dimensional speckle tracking imaging
strain
coronary microvascular dysfunction
Lead sponsor: Peking University Third Hospital
Sponsor class: OTHER
First posted: 2021-07-13
Enrollment: 242
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A total of 242 patients were enrolled, including 102 males (42.1%) and 140 females (57.9%). Their ages ranged from 44 to 81 years, with an average age of (62.6 + 8.3) years.

Brief summary: The study was designed to evaluate the left ventricular longitudinal strain and strain rate assessed by 2D-STI in patients with coronary microvascular dysfunction (CMD) or obstructive coronary artery disease (CAD) , to investigate the effect of different types of ischemic heart disease on the LV systolic function, and to explore the value of LS on the diagnosis of coronary microvascular dysfunction.

Detailed description: A total of 175 patients with chest pain, without wall motion abnormality and without significant coronary artery stenosis (\<50%) assessed by coronary angiography or coronary computed tomography were enrolled from July 2011 to December 2017. Coronary flow reserve (CFR) of these patients were detected by transthoracic Doppler echocardiography. The patients were divided into coronary microvascular dysfunction group ( CFR≤2.5, n=67) and control group (CFR\>2.5, n=108). At the same time, 67 age-matched patients with any major coronary arteries stenosis≥50% and without wall motion abnormality were involved into the obstructive coronary artery disease group. Parameters of global longitudinal strain (LS) and strain rate, subendocardial LS and subepicardial LS were quantified by 2D-STI, the differences of these parameters among three groups were analyzed，correlation analysis、univariate and multivariate analysis and receiver operating characteristic curve were used.

Eligibility criteria: Inclusion Criteria:

* age from 18-85 years

Exclusion Criteria:

* patients with history of myocardial infarction or abnormal wall motion suggested by conventional echocardiography
* patients with acute heart failure, chronic heart failure or LVEF values less than 50%
* patients with congenital heart disease, severe valvular disease, severe bradycardia, high atrioventricular block and atrial fibrillation
* patients who did not store ultrasound images or whose ultrasound images were unclear
* patients who had incomplete clinical data

Primary outcomes:
measure: global longitudinal strain
timeFrame: 15/3/2018-30/12/2018
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Department of Cardiology, Peking University Third Hospital, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides
state: Beijing
Study officials:
affiliation: Peking University Third Hospital
name: Li Zhaoping, professor
role: STUDY_CHAIR
References: