louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00809666: Measuring Blood Pressure in Pregnancy Using Mercury and Automated Device
Official title: A Prospective Randomised Study of Automated Versus Mercury Blood Pressure Recordings in Pregnancy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertension
Pregnancy
Pre Eclampsia
Keywords: pregnancy
hypertension
mercury sphygmomanometry
blood pressure
automated blood pressure
pre eclampsia
Hypertension in pregnancy
Lead sponsor: St George Hospital, Australia
Sponsor class: OTHER
First posted: 2008-12-17
Enrollment: 220
Sex: FEMALE
Minimum age (years): 16
Maximum age (years): 45
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The aim of the PRAM study was to determine whether women diagnosed with hypertension in pregnancy, using the traditional mercury device, have the same pregnancy outcomes when blood pressure is measured by either an automated device or a mercury device throughout the pregnancy.


Eligibility criteria: Inclusion Criteria:

* women with a diagnosis of hypertension in pregnancy

Exclusion Criteria:

* non-pregnant and normotensive pregnancy women

Primary outcomes:
measure: The primary maternal outcome measure was the number of women having any episode of severe hypertension (BP ³ 170/110mmHg).
Secondary outcomes:
measure: Secondary end points included gestation at birth, caesarean section and induction of labour rates.
Other outcomes:
Locations:
city: Sydney
country: Australia
facility: St George Hospital
state: New South Wales
Study officials:
References:
citation: High blood pressure research Council of Australia. Position Statement on the replacement of mercury sphygmomanometers. September 2006. www.hbprca.com.au
citation: Ashworth DC, Maule SP, Stewart F, Nathan HL, Shennan AH, Chappell LC. Setting and techniques for monitoring blood pressure during pregnancy. Cochrane Database Syst Rev. 2020 Jul 23;8(8):CD012739. doi: 10.1002/14651858.CD012739.pub2.
Clinical trial NCT06998966: Optimizing Proton Pump Inhibitors (PPI) Prescribing With EHR-Based Decision Support
Official title: Quality Improvement Initiative Leveraging Electronic Healthcare Records to Reduce Inappropriate Proton Pump Inhibitors (PPI) Prescribing at UCLA.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Prescribing Patterns, Physician
Physician&#39;s Practice Patterns
Drug Utilization Review
Keywords: Proton Pump Inhibitors
Quality Improvement
Healthcare Utilization
Clinical Decision Support
resource utilization
Lead sponsor: University of California, Los Angeles
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
First posted: 2025-05-31
Enrollment: 372
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The proposed study is a quality improvement initiative designed to rigorously evaluate new variations of UCLA Health's proton pump inhibitor (PPI) order panels, building on internal quality improvement efforts to optimize prescribing workflows within the Electronic Health Record (EHR). PPIs are notoriously overprescribed, and the study team has identified that the CareConnect default prescription setting of 90 days with three refills (360 pill days) exceed standard guidelines (in most cases, 60 pill days). It is unclear whether this is the most appropriate workflow. Given that deprescribing PPIs carries minimal risk for most patients, this initiative will assess whether modifying defaulted prescription lengths influences prescribing behavior while ensuring physicians retain full decision-making authority.

This evaluation of PPI order panel variations is embedded within UCLA's existing EHR system, ensuring that changes are tested pragmatically within routine workflows. The study aims to determine whether small adjustments to the order panel can better align prescribing patterns with clinical best practices while maintaining physician autonomy.


Eligibility criteria: Inclusion Criteria:

* UCLA Health primary care physicians who have a clinical full-time equivalency of at least 25%.

Exclusion Criteria:

* Physicians with a clinical full-time equivalency of less than 25%

Primary outcomes:
measure: Inappropriate Pill Days
timeFrame: 12 months
Secondary outcomes:
measure: Prescription Discontinuations
timeFrame: 12 months
measure: Prescription Refills
timeFrame: 12 months
measure: Overall Average Pill Days
timeFrame: 12 months
measure: GI Bleeding Hospitalization
timeFrame: 12 months
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: UCLA Health System
state: California
Study officials:
References:
Clinical trial NCT03616366: The Mechanism and Prognosis of Pulmonary Circulation Dysfunction
Official title: The Mechanism and Prognosis of Pulmonary Circulation Dysfunction in Pulmonary Injury and Recovery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: VTE
Keywords: VTE
SNP
biomarkers
Lead sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital
Sponsor class: OTHER
First posted: 2018-08-06
Enrollment: 1000
Sex: ALL
Minimum age (years): 14
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Acute VTE patients and healthy controls

Brief summary: Venous thromboembolism (VTE) is a condition which influenced by both environmental and genetic factors. This study is going to explore new significant Single nucleotide polymorphisms (SNPs) associated with VTE by Genome-Wide Association Studies (GWAS) and bioinformatics analysis. Transcriptomics and cytokine antibody array are also used to find new biomarkers of VTE's early diagnosis, severity and prognosis.


Eligibility criteria: Inclusion Criteria:

* Chinese Han population older than 14 years old
* Acute VTE patients diagnosed in 1 month
* With informed consent

Exclusion Criteria:

* Patients with psychosis
* Patients with contraindications for computed tomographic pulmonary angiography (CTPA)
* Chronic VTE
* Recurrence of chronic VTE

Primary outcomes:
measure: All cause death
timeFrame: 6 months
Secondary outcomes:
measure: Venous thromboembolism (VTE) recurrence
timeFrame: 6months
measure: chronic thromboembolism pulmonary hypertension(CTEPH)
timeFrame: 6 months
Other outcomes:
Locations:
city: Beijing
country: China
facility: Cardiovascular Institute and Fu Wai Hospital
state: Beijing
Study officials:
References:
Clinical trial NCT02965066: Clinical Study Investigating Safety and Performance of a New Urinary Intermittent Catheter in Healthy Volunteers
Official title: Clinical Study Investigating Safety and Performance of a New Urinary Intermittent Catheter in Healthy Volunteers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Incontinence, Urinary
Lead sponsor: Coloplast A/S
Sponsor class: INDUSTRY
First posted: 2016-11-16
Enrollment: 28
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The aim of the study is to test the performance and safety of a newly developed intermittent catheter in healthy volunteers.


Eligibility criteria: Inclusion Criteria:

1. Have given written informed consent and signed letter of authority
2. Be at least 18 years of age and have full legal capacity
3. Be a male
4. Willing to refrain from using analgetics up to 24 hours prior to catheterization visits
5. Have a negative urine multistix - erythrocytes (Microscopic haematuria)
6. Have a negative urine multistix:

   * Leukocytes
   * Nitrite Or if positive, subsequent negative for bacterial growth in urine culture

Exclusion Criteria:

1. Abnormalities, diseases or surgical procedures performed in the lower urinary tract
2. Symptoms of urinary tract infections (at least one of the following: frequent urination, stinging or pain at urination)
3. Participating in other clinical investigations related to urinary tracts system during this investigation (inclusion to termination) or have previously participated in this investigation
4. Known hypersensitivity toward any of the test products -

Primary outcomes:
measure: Pain
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Coppenhagen
country: Denmark
facility: Rigshospitalet
Study officials:
affiliation: MD at the clinic of urology at Rigshospitalet
name: Per Bagi, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04917666: Process and Outcomes of Horticultural Therapy for People With Disabilities
Official title: Examining the Process and Outcomes of Horticultural Therapy for People With Severe Mental Illness, Intellectual, and Multiple Disabilities
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mental Disorders, Severe
Intellectual Disability
Keywords: horticultural therapy
severe mental illness
care home residents
Lead sponsor: The Hong Kong Polytechnic University
Sponsor class: OTHER
First posted: 2021-06-08
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Horticultural therapy (HT) "is the engagement of a client in horticulture activities facilitated by a trained therapist to achieve specific and documented treatment goals" (American Horticultural Therapy Association, 2012). People's interactions with plants, through goal-orientated horticultural activities in the form of active gardening, as well as the passive appreciation of nature, could be therapeutic to people with mental or intellectual disabilities in many ways (Eling, 2006; Parkinson, Lowe, \& Vecsey, 2011). This study aims to conduct evaluation studies of HT group programmes for care home residents with severe mental illness.

Detailed description: This is a randomized, single-blind, controlled study in which the outcomes of the horticultural therapy program is compared with a comparison group. Outcome measures were compared at Pre-intervention and post-intervention.

Eligibility criteria: Inclusion Criteria:

* diagnosis of severe mental disorder, e.g. schizophrenia, schizoaffective disorder, bipolar disorder.
* age 18 - 65.
* care home resident

Exclusion Criteria:

* organic brain disorder
* difficulties in communication for joining horticultural activity.

Primary outcomes:
measure: Change in Mental Well-being
timeFrame: Pre-test, Postest (8 weeks from pre-test), Change from Pretest to Posttest is assessed
measure: Change in Engagement in Meaningful Activity Scale (EMAS)
timeFrame: Pre-test, Postest (8 weeks from pre-test), Change from Pretest to Posttest is assessed
measure: Change in Perceived Benefits of Horticultural Therapy
timeFrame: Pre-test, Postest (8 weeks from pre-test), Change from Pretest to Posttest is assessed
Secondary outcomes:
Other outcomes:
Locations:
city: Wong Chuk Hang
country: Hong Kong
facility: Tung Wah Group of Hospitals Wong Chuk Hang Complex
Study officials:
affiliation: The Hong Kong Polytechnic University
name: Andrew MH Siu, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02760966: Effectiveness of Alcohol 70º vs Soap on Cord Separation Time and the Complication in the Newborn
Official title: Effectiveness of Alcohol 70º Compared With Soap on Cord Separation Time and the Complication Rate in the Newborn
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Umbilical Cord
Lead sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Sponsor class: OTHER
First posted: 2016-05-04
Enrollment: 34
Sex: ALL
Minimum age (years): 6
Maximum age (years): 20
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Evaluate the effectiveness of alcohol 70º compared with soap on cord separation time and the complication rate in the newborn.

Detailed description: Randomized clinical trial, which objective is to assess the effectiveness of 70º alcohol compared with neutral soap on the cord separation time of a selection of newborns. 34 newborns admitted to the maternity ward of the hospital have participated. The study is divided into two phases, hospital and home. The first stage is located in the hospital, where the patients who will become part of the study are chosen. After receiving the informed letting of the legal guardian the second part of this phase is started; which aim is to explain the steps to be followed to make a correct cleaning cord technique. The home phase consists of being in contact with the family through Whatsapp on the 5th day from birth, the day of the cord fall and 5 days after this fall. Making some simple questions with simple answers such as yes or no and with the possibility, or not, of sending a picture of the cord state in each follow-up visit.

Eligibility criteria: Inclusion Criteria:

* Availability of legal guardians with knowledge and access to Whatsapp.

Exclusion Criteria:

* Admission in the newborn's room.
* Patients with strong concomitant illness, that limits the planned activities or whose current state contraindicates the incorporation of the program.
* Mother's age \< 18 years old.
* Bad controlled mother's diabetes (at least two digits of blood glucose \<180 mg/dl per day), bad alimentation control and/or non-adherence.

Primary outcomes:
measure: Time of cord separation
timeFrame: 15 days
Secondary outcomes:
measure: Umbilical cord infection
timeFrame: 28 days
measure: Omphalitis
timeFrame: 28 days
measure: Pneumonia
timeFrame: 28 days
measure: Diarrhea
timeFrame: 28 days
measure: Tetanus
timeFrame: 28 days
measure: Neonatal mortality
timeFrame: 60 days
measure: Hospital admissions
timeFrame: 60 days
measure: Emergency department admissions
timeFrame: 60 days
measure: Unscheduled consultations
timeFrame: 60 days
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
Study officials:
affiliation: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
name: Lara Perez
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05893966: Prospective Cohort for Tumor Bed Boost Radiotherapy in HER2 Positive Breast Cancer
Official title: Prospective Cohort for Tumor Bed Boost Radiotherapy in HER2 Positive Breast Cancer
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Breast Cancer
Lead sponsor: Samsung Medical Center
Sponsor class: OTHER
First posted: 2023-06-08
Enrollment: 400
Sex: FEMALE
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Any HER2+ invasive breast cancer patient with eligible performance except previous history of radiation therapy to ipsilateral breast

Brief summary: The purpose of this study is to analyze treatment outcomes related to tumor bed boost of postoperative radiation therapy in patient with HER2+ breast cancer who underwent breast conserving surgery.

The main questions it aims to answer are:

* 7-year ipsilateral breast tumor recurrence
* 7-year disease-free survival
* 7-year locoregional recurrence
* 7-year overall survival
* Adverse events of radiation therapy

Participants will be assessed by multi-dimensional methods after radiation therapy:

* Assessment for the disease status (disease-free or recurrence) including physical and radiologic examination
* Assessment for the adverse events according to CTCAE version 5.0


Eligibility criteria: Inclusion Criteria:

* Female patients with age minimum 19
* Pathological confirmation of HER2+ invasive breast cancer
* Eastern Cooperative Oncology Group performance status 0-2
* Informed consent of the participant

Exclusion Criteria:

* Pathological confirmation of ductal carcinoma in situ of the breast
* Previous history of radiation therapy to ipsilateral breast

Primary outcomes:
measure: Ipsilateral breast tumor recurrence
timeFrame: 7 years from the start of the postoperative radiation therapy
Secondary outcomes:
measure: Disease-free survival
timeFrame: 7 years from the start of the postoperative radiation therapy
measure: Locoregional recurrence
timeFrame: 7 years from the start of the postoperative radiation therapy
measure: Overall survival
timeFrame: 7 years from the start of the postoperative radiation therapy
measure: Adverse events
timeFrame: 7 years from the start of the postoperative radiation therapy
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
Study officials:
affiliation: Samsung Medical Center
name: Haeyoung Kim, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02003066: Effect of Goal-directed Fluid Therapy Using Stroke Volume Variation in Patients Undergoing Free Flap Reconstruction After Head and Neck Cancer Resection
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: General Anesthesia
Keywords: Fluid Therapy
Head and Neck Neoplasms
Surgical Flaps
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2013-12-06
Enrollment: 62
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Investigators hypothesized that goal-directed fluid therapy using stroke volume variation will improve postoperative recovery in patients undergoing free flap reconstruction after head and neck cancer resection. Investigators will compare the effect of goal-directed fluid therapy using stroke volume variation on recovery in patients undergoing free flap reconstruction after head and neck cancer resection.


Eligibility criteria: Inclusion Criteria:

* adult patients of age over 20 years scheduled for free flap reconstruction after head and neck cancer resection

Exclusion Criteria:

* valvular heart disease
* congestive heart failure
* liver failure
* renal failure
* pregnant woman
* allergy to hydroxyethyl starch solutions
* coagulation abnormalities

Primary outcomes:
measure: Length of hospital stay
timeFrame: 1 month after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Department of Anesthesiology and Pain Medicine, Yonsei University Health System
Study officials:
References:
citation: Kim HJ, Kim EJ, Lee HJ, Min JY, Kim TW, Choi EC, Kim WS, Koo BN. Effect of goal-directed haemodynamic therapy in free flap reconstruction for head and neck cancer. Acta Anaesthesiol Scand. 2018 Aug;62(7):903-914. doi: 10.1111/aas.13100. Epub 2018 Mar 25.
Clinical trial NCT06033066: Financial Incentives and Recruitment to the APT Webstudy
Official title: A Randomized Trial of Financial Incentives for the Recruitment of County Health System Patients to the Alzheimer Prevention Trials (APT) Webstudy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Alzheimer Disease
Dementia
Preclinical Alzheimer's Disease
Prodromal Alzheimer's Disease
Keywords: Alzheimer's
Prevention
Observational
Trial-Ready Cohort
Lead sponsor: University of Southern California
Sponsor class: OTHER
Collaborators: name: American Heart Association
name: Schaeffer Center for Health Policy & Economics
name: Alzheimer's Therapeutic Research Institute
First posted: 2023-09-13
Enrollment: 48000
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This single-blind, three-arm, randomized, controlled trial will assess the impact of messages and financial incentives on the enrollment of demographically diverse individuals to the Alzheimer Prevention Trials (APT) Webstudy. The APT Webstudy is a novel, online registry that employs quarterly cognitive testing using validated platforms. The APT Webstudy implements fully remote assessments, coordinated by the Alzheimer's Therapeutic Research Institute (ATRI) under USC IRB #HS-17-00746. The purpose of the current study is to test whether we can increase enrollment of diverse individuals into the registry. To do this, we will work with Contra Costa Regional Medical Center (CCRMC), the county public hospital and its affiliated health centers in Contra Costa County, California, to test whether sending messages with and without financial incentives to patients who receive primary care with the health system can increase enrollment to the APT Webstudy. The investigators hypothesize that 1) a certain small financial incentive and an award opportunity based incentive (or a drawing with a prize) will increase enrollment rates of CCHS members into the APT Webstudy relative to the control group. The investigators further hypothesize that the award opportunity incentive will increase the enrollment rate of CCRMC patients into the APT Webstudy more than a certain financial incentive with the same expected value.


Eligibility criteria: Inclusion Criteria:

To be eligible to participate in this study, an individual must meet all of the following criteria:

* Patients empaneled at Contra Costa Regional Medical Center (CCRMC), the county public hospital and its affiliated health centers.
* Age 50 or older
* Literate in either English or Spanish

Exclusion Criteria:

* Below age 50
* Documentation of prior dementia diagnosis

Primary outcomes:
measure: Enrollment status into the APT Webstudy
timeFrame: 2-weeks
Secondary outcomes:
measure: Cost per enrollee
timeFrame: annual
measure: Completion of cognitive assessments within the APT Webstudy
timeFrame: 2-weeks
Other outcomes:
Locations:
city: Martinez
country: United States
facility: Contra Costa Health Plan
state: California
Study officials:
References:
Clinical trial NCT04821466: VR for Symptom Control and Wellbeing
Official title: The Use of Virtual Reality for Symptom Control and Wellbeing in Palliative Care and Oncology Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Oncology
End Stage Cancer
Palliative Care
Hematologic Malignancy
Keywords: Virtual Reality
Lead sponsor: Royal Cornwall Hospitals Trust
Sponsor class: OTHER
First posted: 2021-03-29
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Cohort interrupted time series study
Primary purpose: SUPPORTIVE_CARE

Brief summary: To investigate the effect that a Virtual Reality experience can have on patient symptoms and wellbeing for palliative care and oncology inpatients


Eligibility criteria: Inclusion criteria

* \> 18 years of age
* Inpatient at RCHT know to the palliative care team
* Able to consent
* Able to speak and understand the English language
* Able to use the virtual reality system
* Able to complete ESAS-r Questionnaire

Exclusion criteria

* \<18 years of age
* Patient unable to consent
* Patient unable to speak English
* Unable to use the virtual reality system (e.g. visually impaired)
* Known Epilepsy or seizures or suspected predisposition to seizures (e.g. Brain metastasis)

Primary outcomes:
measure: ESAS-r Quality of Life Scores
timeFrame: Time 0 & Time 60 minutes
Secondary outcomes:
measure: Quantitative clinician experience of VR intervention
timeFrame: Time 60 minutes
measure: Quantitative clinician experience of VR intervention
timeFrame: Time 60 minutes
Other outcomes:
measure: Qualitative patient experience of VR interventions
timeFrame: Time 60 minutes
measure: Repeat VR experiences
timeFrame: 12 Months
Locations:
city: Truro
country: United Kingdom
facility: Royal Cornwall Hospital
state: Cornwall
Study officials:
affiliation: Doctor
name: Niall O Moon, BMBCh
role: PRINCIPAL_INVESTIGATOR
References: