louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01876394: Comparison of Dietary Fats on Vascular Parameters
Official title: Acute Effects of Dietary Fats on Postprandial Vascular Function in Healthy Individuals: Pilot Double Blind, Randomized, Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Healthy
Keywords: Healthy
Arterial Stiffness
Blood Pressure
Blood Glucose
Vascular Function
Lead sponsor: Unity Health Toronto
Sponsor class: OTHER
First posted: 2013-06-12
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: The purpose of the study is to examine the effect of consuming 50g of fat from 5 different sources (coconut, canola, grapeseed, chia, and butter) on arterial stiffness, blood pressure and blood glucose levels. It is hypothesized that butter will have the most detrimental effect on acute vascular function. Canola, grapeseed and chia oil with their decreased content of SFA are hypothesized to impair vascular function to a lesser extent.


Eligibility criteria: Inclusion Criteria:

* Healthy
* Age 18-65 years
* BMI \< 30 kg/m2
* Brachial systolic blood pressure ≤ 140 mmHg
* Brachial diastolic blood pressure ≤ 90 mmHg

Exclusion Criteria:

* Women of childbearing age must not be pregnant or breastfeeding at the time of the study
* BMI \>35kg/m2
* Hypertensive as defined by brachial SBP \>140mmHg and/or DBP \>90mmHg
* Sensitivity to the study product or its sources
* Presence of chronic conditions or illnesses
* Having any gastrointestinal complication or condition
* Chronic use of dietary supplements that alter fat absorption

Primary outcomes:
measure: To compare 5 different dietary fat sources in a liquid meal on postprandial changes in augmentation index (AIx)
timeFrame: 5 separate mornings, measurements taken at baseline and at 60, 120 and 180 minutes
Secondary outcomes:
measure: To investigate whether these dietary fat sources will result in blood pressure changes and a differential glycemic response
timeFrame: 5 separate mornings, blood pressure measurements will be taken at baseline, 60, 120 and 180 minutes. Blood samples will be taken at baseline 15, 30, 45, 60, 90 and 120 minutes
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Risk Factor Modification Centre, St. Michael's Hospital
state: Ontario
Study officials:
affiliation: Risk Factor Modification Centre - St. Michael's Hospital
name: Vuksan Vladimir, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Unity Health Toronto
name: Alexandra Jenkins (Co-investigator), PhD, RD
role: PRINCIPAL_INVESTIGATOR
affiliation: Unity Health Toronto
name: William Watson (Qualified investigator), MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Unity Health Toronto
name: Elena Jovanovski (Co-investigator), MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05091294: The Effect of Injection Rate of Local Anesthetic in Caesarean Section
Official title: Does the Injection Rate of Local Anesthetic Affect the Onset of Sensory Block and Incidence of Hypotension in Caesarean Section
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anesthesia, Spinal
Anesthesia, Obstetrical
Lead sponsor: Karadeniz Technical University
Sponsor class: OTHER
First posted: 2021-10-25
Enrollment: 67
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This randomized double-blind study aimed to compare the effects of two different subaracnoid lokal anesthetic injection rate in cesarean section. Totally 67 patients were included. The groups were compared in terms of maximum sensory and motor block level, time to reach T6 level, hemodynamic changes and nausea- vomiting saved.

Detailed description: A total of 67 patients 18-40 years undergoing cesarean, who were graded as American Society of Anesthesiologists physical status were randomly allocated into two groups, 120-sn injection time (n=34, Group F), 15-sn injection time (n=33, Group S). When the level of the sensory block achieve the T6 level the surgery was let to begin. The groups were compared in terms of hemodynamic values, use of efedrin, the time to achieve sensory block to the T6 level, maximum sensory block level and motor block level.

Eligibility criteria: Inclusion Criteria:

* Anesthesiologists risk score (ASA) I-II risk status
* Singleton pregnancy aged
* Between 18-40 years

Exclusion Criteria:

* Pregnant women with contraindications for spinal anesthesia;
* Placental anomaly;
* Hypertension
* Cardiac disease
* Vascular disease
* Hepatic disease
* Renal disease
* Hemodynamic instability
* Spinal deformity;
* Severe mental retardation
* Weight \< 50 kg or \>110 kg; height \< 140 cm or \> 180 cm
* Metabolic and Acid-base balance disorders
* Emergency patients

Primary outcomes:
measure: sensory block
timeFrame: 2 minutes interval
measure: Hypotension
timeFrame: 2 minutes interval
Secondary outcomes:
Other outcomes:
Locations:
city: Trabzon
country: Turkey
facility: Karadeniz Technical University
Study officials:
affiliation: KARADENİZ TEKNİK ÜNİVERSİTESİ DEPARTMENT OF ANESTHESİOLOGİA AND REANİMATİON
name: Ersagun tugcugil
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05132894: An Osteopathic Assessment of Lower Extremity Somatic Dysfunction in Runners
Official title: An Osteopathic Assessment of Lower Extremity Somatic Dysfunction in Runners
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Somatic Dysfunction of Sacral Region
Somatic Dysfunction of Both Sacroiliac Joints
Somatic Dysfunction of Bilateral Lower Extremities
Keywords: somatic dysfunction
runners
osteopathic
osteopathic assessment
lower extremity
lower extremity somatic dysfunction
running injury
Lead sponsor: The Touro College and University System
Sponsor class: OTHER
First posted: 2021-11-24
Enrollment: 103
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population includes any adult-aged males and females that are self-proclaimed runners confirming that they run at least 1 mile per week. The runners will be categorized based on the quantity of miles run weekly.

The sampling method is non-probability for convenience to easily gather data.

Brief summary: Runners often experience acute/chronic pain due to pre-existing structural somatic dysfunction and/or acquired various overuse injuries of the lower extremity, specifically affecting the ligaments, tendons, muscles and bones. Common structural and function dysfunctions include but are not limited to patellofemoral pain syndrome (PFPS), Achilles tendonitis, iliotibial band syndrome (ITBS), ligamentous and muscle tears, muscle sprains/strains, stress fractures, pes planus, plantar fasciitis, and shin splints.

The purpose of this study is to assess the correlation between acute and chronic pain, overuse injuries, and observational and palpatory findings upon evaluation. With an understanding of the common trends of somatic dysfunctions and etiology of the pain/injury, modified regimen/routine and improved treatment plans can be developed and recommended for runners to better rehabilitate, minimize relapse and reduce compensatory injuries. No medical or osteopathic treatment will be provided.


Eligibility criteria: Inclusion Criteria:

* Self-proclaimed runners that run at least 1 mile per week consistently
* Minimum 18 years old

Exclusion Criteria:

* Non-runners
* Inconsistent runners, do not log at least 1 mile weekly

Primary outcomes:
measure: Structural exam to determine type of Lower Extremity Somatic Dysfunctions in participants
timeFrame: up to 8 weeks
measure: Questionnaire to analyze data on runners' background/history
timeFrame: up to 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Touro College of Osteopathic Medicine
state: New York
Study officials:
References:
Clinical trial NCT00785694: Recurrence of Bladder Cancer After Transurethral Resection With Hexvix
Official title: Recurrence of Bladder Cancer After Transurethral Resection With Hexvix
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE4
Conditions: Bladder Cancer
Lead sponsor: GE Healthcare
Sponsor class: INDUSTRY
First posted: 2008-11-05
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: This is a randomised, comparative, multicentre study to determine if the early recurrence rate of intermediate-risk bladder cancer is similar in subjects treated with multiple instillations of mitomycin C after resection conducted under white light cystoscopy (group A) and subjects treated with 1 instillation of mitomycin C after resection conducted under white light and blue light cystoscopy (group B).


Eligibility criteria: Inclusion Criteria:

* The subject is not of childbearing potential and signed informed consent.
* Subject with 1 or more primary bladder tumours, confirmed on an outpatient cystoscopy or subjects with 1 or more recurrent bladder tumours appearing within 12 months of removal of a previous bladder tumour, confirmed on an outpatient cystoscopy.

Exclusion Criteria:

* The subject was previously included in this study.
* The subject has a history/is suspected to have TaG3 or greater than or equal to T1 tumours or carcinoma in situ (CIS).
* The subject is suspected to have single primary or single recurrent TaG1 tumours when recurrence occurs more than 1 year after initial diagnosis or previous recurrence.
* The subject has known tumours in the prostatic urethra, distal urethra, or upper urinary tract.
* The subject has gross haematuria.
* The subject has a history of porphyria.

Primary outcomes:
measure: Rate of bladder cancer recurrence
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Velizy Cedex
country: France
facility: GE Healthcare Medical Diagnostics
state: Morane Saulnier
Study officials:
affiliation: GE Healthcare
name: Jean-Paul Antonini
role: STUDY_DIRECTOR
References:
Clinical trial NCT03128294: Long Term Survivors in Ovarian Cancer
Official title: Long Term Survivors in Ovarian Cancer
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Ovarian Cancer
Lead sponsor: University Medical Center Groningen
Sponsor class: OTHER
First posted: 2017-04-25
Enrollment: 69
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Long-term survivors of ovarian cancer (\>10 years).

Brief summary: In this study the investigators would like to explore the patient and tumour characteristics of long-term survivors of ovarian cancer (\>10 years). Indentifiying the characteristics of long-term survivors not only helps find prognostic factors for survival but may aid in generating hypotheses for novel therapeutic strategies.


Eligibility criteria: Inclusion Criteria:

To achieve a large enough study population of approximately 80 subjects, patients surviving \>10 years after treatment for stage IIIC/IV epithelial ovarian cancer in the past 25 years will be included from five hospitals. Patients were diagnosed between 1979 and 2006 and treated in the north of the Netherlands. A list of subjects fitting these inclusion criteria will be extracted from the National Cancer Registry (NKR).

Primary outcomes:
measure: Indentifiying the characteristics of long-term survivors
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Groningen
country: Netherlands
facility: University Medical Center Groningen
Study officials:
affiliation: University Medical Center Groningen
name: A.K.L. Reyners, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02951494: Impact of Lower Body Weight Support Treadmill on Cardiopulmonary Exercise Capacity and Trainability
Official title: Einfluss Der Körpergewichtsunterstützung Auf Einem AlterG®-Antigravitationslaufband Auf Die Kardiopulmonale Leistungsfähigkeit Und Trainierbarkeit
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Volunteers
Lead sponsor: University Medicine Greifswald
Sponsor class: OTHER
First posted: 2016-11-01
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The AlterG®-anti-gravity treadmill provides lower body weight support which enables individuals to exercise without feeling their full body weight. How this body weight support influences cardiovascular, respiratory, vascular and metabolic parameters is currently unclear. Further, whether body weight support influences the trainability in response to moderate continuous exercise is unknown. This investigation has two main goals. First, we explore the direct influence of lower body weight support on cardiometabolic parameters during maximal exercise testing. Second, we aim to compare changes in cardiorespiratory fitness in response to a structured exercise protocol using moderate intensity with and without lower body weight support.


Eligibility criteria: Inclusion Criteria:

* maximal oxygen consumption below age-sex specific standard

Exclusion Criteria:

* acute infection within the last four weeks
* anemia (males: Hb \< 8.1 mmol/L; females Hb \< 7.4 mmol/L)
* previous reports of myo-, endo, or pericarditis
* previous stroke or acute myocardial infarction
* heart failure (NYHA \> 1)
* aortic valve stenosis
* congenital heart disease
* cardiomyopathy
* severe left ventricular hypertrophy
* cardiac arrythmias
* hypertension
* diabetes
* BMI \> 35
* cancer
* pregnancy
* aneurysm of aorta or cerebral arteries

Primary outcomes:
measure: Maximal oxygen consumption
timeFrame: 12 weeks
Secondary outcomes:
measure: Oxygen consumption at anaerobic threshold
timeFrame: 12 weeks
measure: Pulse wave velocity
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Greifswald
country: Germany
facility: Cardiovascular examination center of the University Medicine Greifswald
Study officials:
affiliation: University Medicine Greifswald
name: Marcus Dörr, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Brussau T, Oehring R, Felix SB, Dorr M, Bahls M. Cardiorespiratory and metabolic responses to exercise testing during lower-body positive pressure running. J Appl Physiol (1985). 2020 Apr 1;128(4):778-784. doi: 10.1152/japplphysiol.00328.2019. Epub 2020 Feb 13.
Clinical trial NCT06677294: The Effects of Intrauterine Interventions During Placenta Removal on Pain, Perception of Traumatic Birth, and Early Postpartum Health Indicators in Women
Official title: The Effects of Intrauterine Interventions During Placenta Removal on Pain, Perception of Traumatic Birth, and Early Postpartum Health Indicators in Women
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Placenta, Retained
Lead sponsor: Kahramanmaras Sutcu Imam University
Sponsor class: OTHER
First posted: 2024-11-06
Enrollment: 64
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The inclusion criteria required participants to be 18 years or older, to have delivered at term (38-40 weeks), to have had a vaginal delivery, and to have a singleton pregnancy.

Brief summary: A prospective cohort study was conducted with 64 women who had vaginal deliveries at Adana City Training and Research Hospital between October 2023 and May 2024. Women who received intrauterine interventions during the third stage of labor formed the case group (n=32), and those who did not formed the control group (n=32). Data were collected using the Pregnant Information Form, Labor Observation Form, Early Postpartum Period Follow-up Form, Visual Analog Scale (VAS), and Traumatic Birth Perception Scale (TBPS). Findings were determined through regular monitoring and follow-ups during the first 24 hours postpartum.


Eligibility criteria: Inclusion Criteria:

The inclusion criteria required participants to be 18 years or older, to have delivered at term (38-40 weeks), to have had a vaginal delivery, and to have a singleton pregnancy. Additionally, participants must not have been using analgesic medications, must not have had hypertension or preeclampsia, and must not have experienced atony in a previous pregnancy. Participants also needed to be free from infections, placental anomalies, genital lesions, or coagulation disorders, and they had to agree to participate in the study

Exclusion Criteria:

Exclusion criteria included women who experienced a difficult labor or whose delivery involved the use of forceps or vacuum assistance.

Primary outcomes:
measure: Women&#39;s pain levels
timeFrame: VAS scores were recorded at 10 minutes, 30 minutes, 1 hour, 12 hours, and 24 hours postpartum
measure: Traumatic Birth Perception
timeFrame: At 24 hours postpartum
measure: Early postpartum health characteristics
timeFrame: 10th minute, 15th minute, 20th minute, 30th minute, 45th minute, 60th minute, 90th minute, 2nd hour, 3rd hour, 4th hour, 5th hour, 6th hour, 12th hour, 18th hour and 24th hour
Secondary outcomes:
Other outcomes:
Locations:
city: Kahramanmaraş
country: Turkey
facility: Kahramanmaras Sutcu Imam University
Study officials:
References:
Clinical trial NCT01687894: Vasopressin to Prevent Hypotension During Beach Chair Surgery
Official title: Clinical Trials of Vasopressin for Prevention of Hypotension During Shoulder Surgery in Beach Chair Position Under General Anesthesia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rotator Cuff Tear Arthropathy
Keywords: cerebral oxygen saturation
beach chair position
hemodynamic
jugular venous oximetry
Lead sponsor: Chonnam National University Hospital
Sponsor class: OTHER
Collaborators: name: Chonnam National University
First posted: 2012-09-19
Enrollment: 74
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing shoulder surgery in the beach chair position under the general anesthesia

Brief summary: Patients undergoing surgery in beach chair position (BCP) are at risk for cerebral ischaemia. The impacts of arginine vasopressin (AVP) on haemodynamics and cerebral oxygenation are evaluated during surgery in BCP.

Detailed description: Patients undergoing shoulder surgery in BCP under general anaesthesia are randomly allocated to receive i.v. normal saline (control group) or AVP 0.05 or 0.07 U kg-1 (AVP group, n = 15 each) 2 min before moving into BCP. Mean arterial pressure (MAP), heart rate (HR), jugular venous bulb oxygen saturation (SjvO2) and regional cerebral tissue oxygen saturation (SctO2) are measured before (pre-sitting in supine position) and after patients assumed BCP.

Eligibility criteria: Inclusion Criteria: elective arthroscopic shoulder surgery under general anesthesia in beach chair position

Exclusion Criteria: preexisting cerebrovascular diseases, history of orthostatic hypotension, age less than 18 yr, and the American Society of Anesthesiologists physical status IV or V

Primary outcomes:
measure: The magnitude of decrease of mean arterial pressure
timeFrame: Baseline (before positioning) and lowest value within 10 min into beach chair position
Secondary outcomes:
measure: Jugular venous oxygen desaturation
timeFrame: Up to 30 min after the positioning
Other outcomes:
measure: Cerebral oxygen desaturation
timeFrame: Up to 30 min after the position change
Locations:
city: Gwangju
country: Korea, Republic of
facility: Department of Anesthesiology and Pain Medicine
Study officials:
affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital
name: Kyung Y Yoo, M.D.,Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Jang EA, Song JA, Shin JY, Yoon JJ, Yoo KY, Jeong S. Background anaesthetic agents do not influence the impact of arginine vasopressin on haemodynamic states and cerebral oxygenation during shoulder surgery in the beach chair position: a prospective, single-blind study. BMC Anesthesiol. 2017 May 30;17(1):73. doi: 10.1186/s12871-017-0364-9.
Clinical trial NCT00742794: Frequency of Hymenoptera-stings in Patients Under Allergen-Specific Immunotherapy (SIT)
Official title: Frequency of Hymenoptera-stings in Patients Under and After Allergen-specific Immunotherapy: a Retrospective Data-analysis Considering Socio-economic Aspects
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hymenoptera Sting Allergy
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2008-08-28
Enrollment: 200
Sex: ALL
Minimum age (years): 5
Maximum age (years): 90
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Hymenoptera sting allergic patients under allergen specific immunotherapy

Brief summary: In Switzerland, 3.5% of the population are suffering from hymenoptera venom allergy. The only causal treatment of hymenoptera alelrty is venom specific immunotherapy. There are however several reasons, which question the relatively broad application of this expensive treatment. That's why we aim at investigating the actual risk for hymenoptera stings in patients undergoing allergen specific immunotherapy against hymenoptera sting allergy


Eligibility criteria: Inclusion criteria:

* Bee and/or Wasp allergic patients treated by SIT

Exclusion criteria:

* None

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Zurich
country: Switzerland
Study officials:
affiliation: UniversitaetsSpital Zuerich
name: 01 Studienregister MasterAdmins
role: STUDY_DIRECTOR
References: