Clinical trial NCT03275766: Transcranial Magnetic Stimulation (TMS) for Motor Symptoms in Psychiatric Disorders
Official title: Effects of Transcranial Magnetic Stimulation on Motor Symptoms of Patients With Psychiatric Disorders
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Psychomotor Retardation
Psychomotor Slowing
Schizophrenia and Related Disorders
Major Depressive Disorder
Lead sponsor: University of Bern
Sponsor class: OTHER
First posted: 2017-09-08
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Psychomotor slowing may occur in major psychiatric disorders, such as major depressive disorders or schizophrenia spectrum disorders. It refers to slowing of fine motor skills, motor planning and gross motor behavior. In major depression and schizophrenia, psychomotor slowing is associated with alterations of premotor cortex, dorsolateral prefrontal cortex and basal ganglia. This randomized, sham-controlled, prospective trial will test, whether 15 sessions of repetitive transcranial magnetic stimulation (rTMS) may ameliorate psychomotor slowing in schizophrenia or major depression.

Detailed description: Psychomotor slowing may occur in major psychiatric disorders, such as major depressive disorders or schizophrenia spectrum disorders. It refers to slowing of fine motor skills, motor planning and gross motor behavior. In major depression and schizophrenia, psychomotor slowing is associated with alterations of premotor cortex, dorsolateral prefrontal cortex and basal ganglia. This randomized, sham-controlled, prospective trial will test, whether 15 sessions of rTMS in 3 weeks may ameliorate psychomotor slowing in schizophrenia or major depression.

Eligible participants will be randomized to one of four arms:

Eligibility criteria: Inclusion Criteria:

* suffering from major depressive disorder or schizophrenia spectrum disorder according to DSM-5 criteria
* right handedness
* normal or corrected-to-normal vision and hearing

Exclusion Criteria:

* epilepsy
* history of severe head trauma
* current abuse of drugs or alcohol; past addiction to drugs or alcohol
* pregnancy
* incompatibility to cerebral MRI

Primary outcomes:
measure: Number of Responders at Week 3
timeFrame: week 3
Secondary outcomes:
measure: Change in Salpetriere Retardation Rating Scale Total Score From Baseline to Week 3
timeFrame: week 3
measure: Change in Activity Level From Baseline to Week 3
timeFrame: week 3
measure: Change in Catatonia Severity From Baseline to Week 3
timeFrame: week 3
measure: Change in Fingertapping Score From Baseline to Week 3
timeFrame: week 3
measure: Change in Coin Rotation From Baseline to Week 3
timeFrame: week 3
measure: Change in Hand Gesture Performance From Baseline to Week 3
timeFrame: week 3
measure: Change in SANS Total Score From Baseline to Week 3
timeFrame: week 3
measure: Change From HAMD Total Score From Baseline to Week 3
timeFrame: week 3
measure: Change in CAINS Total Score From Baseline to Week 3
timeFrame: week 3
measure: Change in PANSS Total and Subscores From Baseline to Week 3
timeFrame: week 3
Other outcomes:
Locations:
city: Bern
country: Switzerland
facility: University Hospital of Psychiatry, University of Bern
Study officials:
affiliation: University of Bern, University Hospital of Psychiatry
name: Sebastian Walther, MD
role: PRINCIPAL_INVESTIGATOR
References: