louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05836857: The Use of Cannabis (Marijuana) and Cannabidiol (CBD) Among Cancer Patients: A Pilot Study
Official title: The Use of Cannabis (Marijuana) and Cannabidiol (CBD) Among Cancer Patients: A Pilot Study
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Cancer
Lead sponsor: M.D. Anderson Cancer Center
Sponsor class: OTHER
First posted: 2023-05-01
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: M D Anderson Cancer Center

Brief summary: To collect information about how patients in the pain management clinic use cannabis/CBD, including how often it is used, why it is used (for example, to manage pain or other symptoms), and where patients get their information on cannabis/CBD for pain management

Detailed description: Objectives

Primary Objective:

The primary objective of this study is to investigate the prevalence of current and prior cannabis and/or CBD use in cancer patients who present to the pain management clinic at MDACC.

Secondary Objectives:

The secondary objective is to investigate the reason for cannabis/CBD use (e.g. pain, neuropsychiatric symptoms, recreational or other use), degree of symptom improvement with use, frequency of use, methods of use (e.g. inhaled vs. ingested), sources of information on cannabis/CBD, and patient interest in learning more from their physicians about cannabis/CBD for cancer pain.

Eligibility criteria: Inclusion Criteria:

1. Age 18 years or older
2. Cancer patients who present to the MD Anderson Pain Medicine Clinic as a new patient or consult
3. Willing to give informed consent
4. Willing to complete the survey

Exclusion Criteria:

1. Refusal of informed consent
2. Refusal to complete the survey
3. Patients who previously completed the survey
4. Patients who opt-out or change their mind after agreeing to participate
5. Already an established patient at MDACC Pain Medicine Clinic
6. Patients scheduled to see Dr Abdi (PI).

Primary outcomes:
measure: Cannabis (Marijuana) and CBD (Cannabidiol for Cancer Pain Survey
timeFrame: through study completion; an average of 1 year.
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: M D Anderson Cancer Center
state: Texas
Study officials:
affiliation: M.D. Anderson Cancer Center
name: Salahadin Abdi, MD,PHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06421857: Hemostatic Measures During Laparoscopic Cystectomy for Endometrioma
Official title: Bipolar Coagulation Versus Suturing During Laparoscopic Endometriotic Cystectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Endometrioma
Lead sponsor: Ain Shams Maternity Hospital
Sponsor class: OTHER
First posted: 2024-05-20
Enrollment: 48
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: laparoscopic excision of ovarian endometriotic cysts is generally recommended because it has been associated with a higher spontaneous conception rate, residual ovarian function after the procedure may be affected


Eligibility criteria: Inclusion Criteria:

* 18 to 35 years
* unilateral endometriotic cyst

Exclusion Criteria:

anovulatory women women with decreased ovarian reserve women receiving hormonal treatment three months prior to surgery women with any contraindication to laparoscopy women with previous ovarian surgery possible ovarian malignancy.

Primary outcomes:
measure: ovarian reserve
timeFrame: 6 weeks after procedure
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams university
Study officials:
affiliation: Ain Shams University
name: Osama Kamel, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT06037057: Application of Artificial Intelligence Deep Learning Technology in Magnetic Resonance Lumbar Imaging
Official title: Application of Artificial Intelligence Deep Learning Technology in Magnetic Resonance Lumbar Imaging
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Deep Learning,Lumbar Magnetic Resonance Imaging
Lead sponsor: RenJi Hospital
Sponsor class: OTHER
First posted: 2023-09-14
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients of both sexes, aged ≥18 years, with no history of lumbar surgery, underwent lumbar magnetic resonance imaging examination.

Brief summary: To study the comparative analysis of artificial intelligence deep learning technology in the image quality of under-artificial intelligence (AI) reconstruction images and the original acquisition images of magnetic resonance lumbar spine


Eligibility criteria: Inclusion Criteria:

* Patients of both sexes, aged ≥18 years, with no history of lumbar surgery, underwent lumbar magnetic resonance imaging examination.

Exclusion Criteria:

* With metal implants in the body, claustrophobic, unable to lie flat for 15 minutes, with a history of lumbar surgery.

Primary outcomes:
measure: Application of Artificial Intelligence Deep Learning Technology in Magnetic Resonance Lumbar Imaging
timeFrame: 2025.3-2025.6
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00266357: Sleep Laboratory Study of MK0928 in Adult Patients With Primary Insomnia (0928-041)(TERMINATED)
Official title: MK0928 Phase II Sleep Laboratory Study - Primary Insomnia
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
Conditions: Primary Insomnia
Lead sponsor: H. Lundbeck A/S
Sponsor class: INDUSTRY
First posted: 2005-12-16
Enrollment: 50
Sex: ALL
Minimum age (years): 20
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: A study to evaluate the efficacy, safety and tolerability of MK-0928 in Primary Insomnia.


Eligibility criteria: Inclusion Criteria:

* Patients with a diagnosis of primary insomnia

Exclusion Criteria:

* Patients with an active psychiatric disorder other than primary insomnia

Primary outcomes:
measure: Mean of total sleep time over 2 nights.
Secondary outcomes:
measure: Mean of other PSG sleep parameters over 2 nights, mean of subjective sleep parameters, and exploratory residual effect.
Other outcomes:
Locations:
Study officials:
affiliation: Merck Sharp & Dohme LLC
name: Medical Monitor
role: STUDY_DIRECTOR
References:
Clinical trial NCT02073357: The BALANCED Anaesthesia Study
Official title: The BALANCED Anaesthesia Study A Prospective, Randomised Clinical Trial of Two Levels of Anaesthetic Depth on Patient Outcome After Major Surgery
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Effect of General Anesthetic Dose on Recovery From Surgery
Lead sponsor: The Cleveland Clinic
Sponsor class: OTHER
Collaborators: name: National Health and Medical Research Council, Australia
First posted: 2014-02-27
Enrollment: 0
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: General anaesthesia is a reversible drug-induced coma. Too little can result in patients being partially conscious during surgery; too much can slow recovery after surgery. There is a range of drug doses that can be used and some anesthesiologists use more than others. There is no convincing evidence that any particular dose within the usual range is better. Consequently, there are no guidelines on the best depth of anaesthesia. This study will determine whether general anesthetic concentrations at the low end of the usual range are better than those at the high end.

Participants will randomly be assigned to lighter or deeper general anesthesia. The first day after surgery, two short questionnaires about recovery and memories of the surgery will be completed. During the rest of the participant's hospital stay, a survey about how one feels will be completed.

There will be two telephone contacts after discharge from the hospital. One month after surgery three questionnaires will be completed about performing daily tasks, how you feel and memories of the surgery. Then one year after surgery pain will be assessed.


Eligibility criteria: Inclusion Criteria:

* Age ≥60 years
* ASA physical status 3 or 4
* surgery expected to last ≥2 hours
* post-operative hospital stay expected to be ≥2 nights
* general anaesthesia with or without major regional block
* able to monitor BIS throughout anaesthesia

Exclusion Criteria:

* Unable to monitor BIS (e.g. cranial or intracranial surgery)
* unable to consent
* surgery with 'wake-up' test
* propofol infusion for part or all of maintenance of anaesthesia ('total intravenous anaesthesia')
* previous enrolment in Balanced study

Primary outcomes:
measure: One-year all-cause mortality
timeFrame: One year
Secondary outcomes:
Other outcomes:
Locations:
city: Cleveland
country: United States
facility: Cleveland Clinic
state: Ohio
Study officials:
affiliation: The Cleveland Clinic
name: Daniel Sessler
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04471857: Hypnosis for Children Undergoing Anorectal Manometry
Official title: Using Medical Hypnotherapy in Children With Defecation Disorders
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Constipation
Keywords: hypnosis
anorectal manometry
child
Lead sponsor: Nationwide Children's Hospital
Sponsor class: OTHER
Collaborators: name: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
First posted: 2020-07-15
Enrollment: 34
Sex: ALL
Minimum age (years): 4
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Partially blinded randomized controlled trial investigating the effect of a brief session of hypnosis prior to anorectal manometry in children


Eligibility criteria: Inclusion Criteria:

* Children aged 4-18 who are scheduled to undergo anorectal manometry testinf.
* ASA classification I to II.
* Both parents and children have sufficient English language proficiency.
* Both parents and children are willing to fill out the questionnaires involved in this study.

Exclusion Criteria:

* ASA classification III, IV (children with a chronic or severe disease).
* Children with a metabolic, endocrine or neuromuscular disorder or mental illness.
* Children with anorectal malformations or previous anorectal surgery.
* Children with developmental delay
* Children with diagnosed emotional or behavioral disorders

Primary outcomes:
measure: The primary outcome of this study will be the assessment of distress as measured by the non-blinded observer.
timeFrame: Periprocedural
Secondary outcomes:
measure: Periprocedural distress as measured by the blinded observer
timeFrame: Periprocedural
measure: Child-reported levels of distress
timeFrame: Right after anorectal manometry (same day)
measure: Parent-reported levels of distress
timeFrame: Right after anorectal manometry (same day)
measure: Difficulty of procedure
timeFrame: Right after anorectal manometry (same day)
measure: Difficulty of hypnosis
timeFrame: Right after anorectal manometry (same day)
measure: Manometry outcomes
timeFrame: Periprocedural
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05810857: Comparative Effects of Motor Relearning Programme Versus Mirror Therapy on Balance and Gait in Chronic Stroke Patients
Official title: Comparative Effects of Motor Relearning Programme Versus Mirror Therapy on Balance and Gait in Chronic Stroke Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Stroke
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2023-04-12
Enrollment: 36
Sex: ALL
Minimum age (years): 45
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: To determine the effect of Motor Relearning Program versus Mirror Therapy for balance and gait in chronic ischemic stroke patients


Eligibility criteria: Inclusion Criteria:

* • Chronic ischemic stroke of six or more than six months.

  * Patients with age - 45- 65 years.
  * Patients with good cognitive status i.e. 20 or more on MMSE.(Mini Mental Status Examination).
  * Patients of both genders
  * Patients with ambulation before stroke.

Exclusion Criteria:

* • Patients who have musculoskeletal disorder impending lower limb function.

  * Patient with any other Neurological disease.
  * Patients have severe lower limb deformities, and vestibular disorders.
  * Patients who have any joint disorder of lower limb.
  * Patients who have any cardiac problem.
  * Patients with history of recurrent stroke.

Primary outcomes:
measure: Mirror Therapy Techinique, Motor Relearning Programme Techinique
timeFrame: 6 Months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04557657: Evaluation of Marginal Integrity Using Bioactive Cement Incementation of Indirect Composite Blocks
Official title: Evaluation of Marginal Integrity Using Modified USPHS Criteria of a Bioactive Cement in Comparison to Resin Cement in Cementation of Indirect Composite Blocks: A Randomized Clinical Trial 12 Month Follow up
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Resin Cement
Keywords: Composite blocks
Cad/Cam
Cerec
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-09-21
Enrollment: 40
Sex: ALL
Minimum age (years): 16
Maximum age (years): 65
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 36 volunteer assigned randomly into 2 equal groups of 18
Primary purpose: TREATMENT

Brief summary: The aim of this study is to evaluate of marginal integrity of indirect composite restoration after cementation by a bioactive cement in comparison to dual cure resin cement using Modified USPHS criteria

Detailed description: The study will be conducted in Conservative Dentistry Department, Faculty of Dentistry, Cairo University, The operator in charge will be: Mohamed Sherif . The researcher will bear ultimate responsibility for all activities associated with the conduct of a research project including recruitment of patients, explaining and performing the procedures to them,A total of 36 volunteer patients with Patients with badly broken vital teeth with minimum of two remaining walls. Patients will be randomly divided into two groups according to type of cement (S) where in group S1, Restoration will be cemented with resin cement ; while group S2,Restoration will be cemented with active cement. Each restoration will be assessed after three, six months and one year using modified USPH Criteria Marginal Discoloration, Recurrent Caries and Marginal Chipping with scale of Alpha and non alpha

Eligibility criteria: Inclusion Criteria:

* Patients with badly broken vital teeth with minimum of two remaining walls
* Adult Males or female 16- 65 years old
* Good oral hygiene measures with a good gingival condition
* Cooperative patients approving to participate in the study
* Free of any medical condition that interfere with procedures

Exclusion Criteria:

* Patients with a compromised medical history.
* Severe or active periodontal disease
* Endodontically treated teeth
* Severe medical complications Lack of compliance

Primary outcomes:
measure: Marginal Discoloration
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo University
state: EL Manial
Study officials:
References:
Clinical trial NCT03782857: Prevention After Stroke - a Nurse-led Physician-supervised Model
Official title: Prevention After Stroke - a Nurse-led Physician-Supervised Model. A Feasibility Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke
Lead sponsor: Herlev Hospital
Sponsor class: OTHER
First posted: 2018-12-20
Enrollment: 78
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants were randomized 1:1 to intervention or control group
Primary purpose: PREVENTION

Brief summary: The study evaluates the effect of early follow up in a preventive clinic with stepwise treatment of high blood pressure and lowering blood cholesterol. Half the participants were randomized to the preventive clinic group and the other half to control group with the usual treatment: one visit to the outpatient clinic three months after discharge with a diagnosis of stroke or transient ischemic attack (TIA)

Detailed description: Hypertension is the most important modifiable risk factor for recurrent stroke. Several studies have shown that less than 40% of stroke survivors are treated to target one year after stroke The investigator performed a feasibility study to test a model of treating this important risk factor in a hospital setting The investigator used a stepwise escalation of treatment of both blood pressure and blood cholesterol to individual targets according to patients' diagnosis of stroke, comorbidity and age

Eligibility criteria: Inclusion Criteria: Patients diagnosed with a stroke during stay in the stroke unit of Herlev Hospital

Exclusion Criteria: Severe stroke giving a modified Rankin Scale score \>4, severe cognitive deficits or dementia, discharge to a nursing home

Primary outcomes:
measure: Blood pressure treated to target
timeFrame: At follow up 10 months after inclusion in the study
Secondary outcomes:
measure: Reduction in blood pressure
timeFrame: At follow up 10 months after inclusion in the study
Other outcomes:
measure: Reduction in LDL-cholesterol
timeFrame: At follow up 10 months after inclusion in the study
measure: LDL-cholesterol treated to target
timeFrame: At follow up 10 months after inclusion in the study
measure: Intensification of preventive treatment
timeFrame: From discharge from the stroke unit to final follow up in study
measure: Adherence with preventive medication
timeFrame: At follow up 10 months after inclusion in the study
measure: Healthy lifestyle
timeFrame: At follow up 10 months after inclusion in the study
measure: Time to cardiovascular complications
timeFrame: From inclusion in the study to a median of 65 (61-66) months after inclusion
Locations:
Study officials:
affiliation: Department of Neurology, Herlev Hospital, 2730 Herlev, Denmark
name: Nete Hornnes, MPH,Ph.d
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02352857: Glycaemic and Insulinaemic Responses After Consumption of FOS.
Official title: Postprandial Glycaemic and Insulinaemic Responses After Consumption of Minicakes Containing FOS in Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Glycaemia
Keywords: Fructo-oligosaccharides
Sugar-reduced foods
Postprandial glucose response
Lead sponsor: Institut Pasteur de Lille
Sponsor class: OTHER
Collaborators: name: Syral
First posted: 2015-02-02
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: The study aims to evaluate the glycaemic and insulinaemic response of short-chain fructo-oligosaccharides (scFOS) used to replace sugars (e.g. dextrose) in foods.


Eligibility criteria: Inclusion Criteria:

* Body mass index (BMI) between 18.0 and 25.0 kg/m² (included);
* Ready to keep the same volume of physical activity and the same dietary habits during the study and particularly 24 hours before each visit;
* Be used to have breakfast;
* Non-smoker for at least 3 months;
* For the female participant: not being pregnant or breastfeeding and using efficient birth control;
* Signed the consent form;
* Able to follow the instructions of the study;
* Health insured;
* Accepted to be included in the National Registry for biomedical research Volunteers (Fichier VRB, Volontaires Recherches Biomédicales).

Exclusion Criteria:

* Fasting blood glucose over 6.1 mmol/L (1.10 g/L) (or diabetes treated or not);
* Fasting blood cholesterol over 6.35 mmol/L;
* Fasting blood triglycerides over 1.70 mmol/L (or history of insulinoma);
* Fasting blood insulin under 20 mU/L;
* Fasting HbA1c under 7%;
* History of hypercholesterolemia, hypertension, diabetes or glucose intolerance treated or not;
* History of dietary allergies or coeliac disease;
* History of digestive system disease susceptible to modify digestion or absorption like Crohn's disease;
* Somatic or psychiatric disorders;
* Renal insufficiency (kidney failure);
* SGOT or ALAT over 52.5 U/L;
* Smoker;
* Consuming more than 3 alcoholic beverage a day;
* Weight varied 3 kg the last 3 months.

Primary outcomes:
measure: Glycaemic response
timeFrame: 2 hours and 5 minutes
Secondary outcomes:
measure: Insulinaemic response
timeFrame: 2 hours and 5 minutes
measure: Blood glucose peak (Cmax)
timeFrame: One-time data (the highest one) within the 2hrs 5mins kinetics.
measure: Blood insulin peak (Cmax)
timeFrame: One-time data (the highest one) within the 2hrs 5mins kinetics.
measure: Glucose Tmax : time to reach the peak of blood glucose
timeFrame: One time within the 2hrs 5mins kinetics.
measure: Insulin Tmax : time to reach the peak of blood insulin
timeFrame: One time within the 2hrs 5mins kinetics.
Other outcomes:
Locations:
city: Lille
country: France
facility: NutrInvest - Institut Pasteur de Lille
state: Nord
Study officials:
affiliation: Institut Pasteur de Lille
name: Jean-Michel LECERF, MD
role: PRINCIPAL_INVESTIGATOR
References: