Clinical trial NCT01962857: Effect of 4 Weeks of Shuttle Run Training on Insulin Sensitivity in Sedentary Men
Official title: Effect of 4 Weeks of Shuttle Run Training on Insulin Sensitivity in Sedentary Men
Study type: INTERVENTIONAL
Overall status: SUSPENDED
Phase: NA
Conditions: Insulin Resistance
Obesity
Metabolic Syndrome
Keywords: Physical activity
Exercise
Insulin resistance
High intensity interval training
Fat oxidation
Fitness
Lipids
Blood pressure
Lead sponsor: University of Glasgow
Sponsor class: OTHER
First posted: 2013-10-14
Enrollment: 30
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: A number of studies have shown that short duration, high intensity interval training can improve health-related outcomes, such as insulin sensitivity and cardiorespiratory fitness. However, these often use specialized equipment, such as cycle ergometers, which makes it difficult to roll these interventions out for wide-scale use in the general population. This study aims evaluate the effects of a high intensity shuttle running intervention on insulin sensitivity, fitness and related cardiometabolic risk factors in men who are currently inactive. Participants will be randomized into intervention (4 weeks of shuttle running) and control groups. We hypothesize that the shuttle running programme will result in improved insulin sensitivity, fitness and increased fat oxidation at rest compared with the control group.


Eligibility criteria: Inclusion Criteria:

* male
* 18-40 years
* undertaking \< 1 hour per week of planned exercise

Exclusion Criteria:

* BMI \> 35 kg/m2
* Blood pressure \> 160/90 mm Hg (on anti-hypertensive medication)
* history of established coronary heart disease
* family history of early cardiac death (\<40 years)

Primary outcomes:
measure: Insulin sensitivity
timeFrame: Change from baseline immediately post-intervention (4 weeks after baseline)
Secondary outcomes:
measure: Resting substrate utilization
timeFrame: Change from baseline immediately post-intervention (4 weeks after baseline)
measure: Endurance exercise performance
timeFrame: Change from baseline immediately post-intervention (4 weeks after baseline)
measure: Sprint exercise performance
timeFrame: Change from baseline immediately post-intervention (4 weeks after baseline)
measure: Body weight
timeFrame: Change from baseline immediately post-intervention (4 weeks after baseline)
measure: Waist circumference
timeFrame: Change from baseline immediately post-intervention (4 weeks after baseline)
measure: Percentage body fat
timeFrame: Change from baseline immediately post-intervention (4 weeks after baseline)
measure: Clustered Cardiometabolic Risk Score
timeFrame: Change from baseline immediately post-intervention (4 weeks after baseline)
Other outcomes:
measure: Objectively measured physical activity
timeFrame: Change from baseline to week 4 of intervention
Locations:
city: Glasgow
country: United Kingdom
facility: University of Glasgow
Study officials:
affiliation: University of Glasgow
name: Jason Gill, PhD
role: PRINCIPAL_INVESTIGATOR
References: