Clinical trial NCT06414291: Rehydration Efficiency During Ad-libitum Fluid Intake
Official title: Rehydration Efficiency During Ad-libitum Fluid Intake
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Dehydration
Lead sponsor: Arizona State University
Sponsor class: OTHER
First posted: 2024-05-16
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: It is well established that rehydration with a carbohydrate-electrolyte solution is more effective in comparison to plain water. This is primarily based on the sodium-glucose co transporter, based on which the world health organization has based its oral rehydration solution recommendations. Also, rehydration with a solution that includes sodium and glucose plasma osmolality should not drop as much as it happens during rehydration with water. As a result, we should have higher fluid intake due to higher thirst perception and lower urinary output due to higher levels of vasopressin.

The present study aims to examine the effectiveness of a electrolyte-glucose drink on rehydration following exercise-induced dehydration.


Eligibility criteria: Inclusion Criteria:

* Age 18-60 years
* Training at least 2 times per week
* stable weight for the last 2 months (fluctuation less than 5 pounds)

Exclusion Criteria:

* Night shifting work
* Thyroid medication
* Bariatric surgery
* Cardiovascular disease
* Renal disease
* Hepatic disease
* Participating in another study at the same time
* Bodyweight over 110 pounds

Primary outcomes:
measure: Total fluid intake
timeFrame: 4 hours of rehydration
measure: Net fluid balance
timeFrame: at 4 hours of the rehydration period
measure: Net fluid balance
timeFrame: at 3 hours of the rehydration period
measure: Rate of absorption
timeFrame: during the first 30 minutes of rehydration
measure: Rate of absorption
timeFrame: during the first 60 minutes of rehydration
measure: Rate of absorption
timeFrame: during the first 120 minutes of rehydration
measure: Rate of absorption
timeFrame: during the first 180 minutes of rehydration
measure: Rate of absorption
timeFrame: during the first 240 minutes of rehydration
measure: Cumulative urine output
timeFrame: during the first 3 hours of rehydration
measure: Cumulative urine output
timeFrame: during the first 4 hours of rehydration
Secondary outcomes:
measure: Plasma copeptin
timeFrame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
measure: Plasma volume
timeFrame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
measure: Free water Clearance
timeFrame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
measure: Free Osmotic Clearance
timeFrame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
measure: Thirst
timeFrame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
measure: Stomach fullness
timeFrame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
measure: Taste Likeness
timeFrame: at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Interdisciplinary Science and Technology Building 8
state: Arizona
Study officials:
References: