Clinical trial NCT03025438: Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation
Official title: Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hepatic Angiosarcoma
Keywords: angiosarcoma
Cytology
liver
cancer
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2017-01-19
Enrollment: 13
Sex: ALL
Minimum age (years): 20
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients of a medical center in Taiwan; National Taiwan University Hospital (NTUH)

Brief summary: Cytological diagnosis of hepatic angiosarcoma by fine-needle aspiration (FNA) or imprint cytology is difficult due not only to its various cytomorphologic features but also clinical rarity. Vasoformative features, such as pseudo-acini, branching pseudo-capillary structure, and intracytoplasmic lumina, are clues to achieve the diagnosis. But these features are not always present. In order to find clues for cytological diagnosis of angiosarcoma, we collected cases of hepatic angiosarcoma to study their cytological features. And then compared these features with those in their histopathological biopsy or resection.

Detailed description: Hepatic angiosarcoma is a rare hepatic malignant tumor. Although diagnosis of hepatic angiosarcoma by FNA cytology has been reported since 1982, followed by several studies, its cytomorphologic features were still not well recognized by cytopathologists because of its clinical rarity and various morphologic features.

We reviewed literatures about cytomorphology of hepatic angiosarcoma by FNA. There are only 11 cases retrieved in 10 articles searched from Medline. The sex M/F ratio was 6/4 (one unknown); age range was 56 to 79 years old. In initial cytological evaluation, four cases got angiosarcoma or consistent/suspicious angiosarcoma diagnosis. Positive for malignancy, sarcoma, and poorly differentiated spindle cell lesion were in one case respectively. One was diagnosed as atypical cells. Remaining three were unavailable by their reports.

In cytological morphologic features, all but one met least 2 of 3 cytological cellular criteria of angiosarcoma cells: spindle cells, epithelioid cells, and pleomorphic cells. In cytological architectural features, 7 of 11 cases showed vasoformative structures; 5 of 11 cases showed intracytoplasmic lumen or erythrophagocytosis. Ten of 11 cases had histologic/pathologic confirmation as angiosarcoma. One case reported interrelation of tumor structures and their own accompanied liver tissue in cell blocks.

Eligibility criteria: Inclusion criteria:

Consecutive patients of hepatic angiosarcoma performed FNA and/or imprint cytological examinations in our hospital.

Exclusion criteria:

1. Patients without pathological confirmation.
2. Patients who are not angiosarcoma by pathological reviews.

Primary outcomes:
measure: all cause mortality
timeFrame: about 10 years from the date of diagnosis to the last follow-up date by medical record
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital, Department of laboratory medicine
Study officials:
affiliation: National Taiwan University Hospital
name: Wern-Cherng Cheng, MD
role: PRINCIPAL_INVESTIGATOR
References: