Clinical trial NCT03556176: The Influence of 5-HTTLPR and BDNF Polymorphisms on Anxiety and Mood After Acute Exercise
Official title: The Influence of 5-HTTLPR and BDNF Polymorphisms on Anxiety and Mood After Acute Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Polymorphisms
Exercise
Mood
Keywords: Anxiety
Mood
Physical activity
Polymorphisms
Lead sponsor: Universidade Federal de Goias
Sponsor class: OTHER
First posted: 2018-06-14
Enrollment: 180
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: The Influence of 5-HTTLPR and BDNF Polymorphisms on Anxiety and Mood After Acute Exercise.

Introduction: The 5-HTTLPR (SLC6A4) and BDNF (Val66Met) polymorphism presents an action on the modulation of human behavior and has received great attention as a risk factor for several psychiatric disorders. In recent years, a growing number of studies have evaluated the association between these polymorphisms and personality traits related to anxiety and depression. Objectives: To determine the frequencies of 5-HTTLPR and BDNF polymorphisms in a college students population; To determine the influence of 5-HTTLPR and BDNF polymorphisms on mood states and anxiety after acute physical exercise. Material and Methods: Four hundred (400) College students will be assessed.

In the first phase of the study, the following procedures will be performed: Screening, Aerobic Fitness Assessment (Step Test), Questionnaires (PAR-Q, Habitual Physical Activity Level, Beck Anxiety and Depression Scale, State-Trait Anxiety, and Perceived Stress Scale), blood sample collection and genotyping. In the second phase of the study, two (2) groups with or without polymorphisms will be selected (for each gene). These groups will be submitted to four conditions (three experimental conditions and one control condition), carried out randomly and separated by an interval of 1 week. In the experimental Conditions the volunteers will perform treadmill exercises sessions (30 minutes) in three different intensities (light, moderate and vigorous) and will respond to the Borg Scale at 10, 20 e 30 minutes. In the control condition the volunteers will be instructed to remain seated (quiet rest), relaxed and silent for 30 minutes. In both conditions, the volunteers will complete the Profile of Mood States (POMS) and State-Anxiety (STAY), 05 (five) minutes before and, 5 (five) and 20 (twenty) minutes following the interventions.


Eligibility criteria: Inclusion criteria:

* 18-30 years of age;
* able to perform physical activities;

Non-inclusion criteria:

* history of cardiovascular or respiratory diseases;
* smoking;
* use of psychiatric drugs;
* psychotherapy treatment in the last six months.

Primary outcomes:
measure: Response of mood states after interventions
timeFrame: Change from 5 minutes before the treatments to 5 and 20 minutes after three exercise intensities and quiet rest
measure: Response of anxiety after interventions
timeFrame: Change from 5 minutes before the treatments to 5 and 20 minutes after three exercise intensities and quiet rest
Secondary outcomes:
measure: Evaluation safety or possible risk of exercising
timeFrame: baseline
measure: Habitual Physical Activity Level
timeFrame: Baseline
measure: Evaluation of depression and anxiety symptoms
timeFrame: Baseline
measure: Estimation the aerobic capacity
timeFrame: Baseline
measure: Detection of the polymorphism in the SLC6A4
timeFrame: Baseline
measure: Detection of the polymorphism BDNF Val66Met SNP rs6265 genotype (G196A)
timeFrame: Baseline
Other outcomes:
Locations:
city: Jataí
country: Brazil
facility: UFG
state: Goiás
Study officials:
References: