Clinical trial NCT05652140: Cardiorespiratory Fitness, Apolipoprotein E Genotype, and Cognitive Functions: A Prospective Study
Official title: Cardiorespiratory Fitness and the Apolipoprotein E (ApoE) Genotype and Its Interaction With Cognitive Functions and Cognitive Decline in Late-Middle-Aged Older Adults: A Prospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Aging
Cognitive Change
Keywords: physical fitness
Apolipoprotein E
event-related potential
Lead sponsor: National Taiwan Normal University
Sponsor class: OTHER
First posted: 2022-12-15
Enrollment: 159
Sex: ALL
Minimum age (years): 50
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cognitively healthy late-middle-aged older adults recruited from the northern part of Taiwan.

Brief summary: The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions.

Detailed description: The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions. The three main purposes of the current research project seek to achieve:

1. An exploration of the associations of, as well as the interactions between, CRF assessed at the Baseline Stage, and the ApoE genotype, along with cognitive functions in cognitively healthy late-middle-aged older adults.
2. The employing of an event-related potential (ERP) to investigate the associations between the baseline CRF, the ApoE genotype, and cognitive functions in cognitively healthy late-middle-aged older adults, as well as the potential underlying neuroelectrical mechanisms.
3. An investigation of the interactions between the changes of CRFs assessed at the Baseline and the Follow-Up Stages and the ApoE genotype in relation to neurocognitive function, as well as the underlying neuroelectrical mechanisms, in cognitively healthy late-middle-aged older adults.

Eligibility criteria: Inclusion Criteria:

* right handed
* no history of cardiorespiratory disease
* normal or corrected-to-normal vision based on the 20/20 standard
* no risk of performing physical activities, as measured by the Physical Activity Readiness Questionnaire

Exclusion Criteria:

* the scores of Mini-Mental Status Examination (MMSE) \< 25 and cognitively intact upon study entry
* history of psychiatric or neurological diseases
* color-blindness

Primary outcomes:
measure: Changes in Inhibitory Performance: Stroop Task
timeFrame: 30 minutes each at the Baseline and the Follow-Up visit at Month 18
measure: Changes in Neuroelectrical Activities
timeFrame: 30 minutes each at the Baseline and the Follow-Up visit at Month 18
Secondary outcomes:
measure: Number of Participants for Whom ApoE Genotype Was Determined
timeFrame: 5 minutes at the Baseline Stage.
measure: Physical Fitness Measurements: Changes in Aerobic Fitness
timeFrame: 30 minutes each at the Baseline and the Follow-Up visit at Month 18
Other outcomes:
measure: Changes in Higher Order Executive Performance: Tower of London Test
timeFrame: 30 minutes each at the Baseline and the Follow-Up Stages.
Locations:
city: Taipei
country: Taiwan
facility: Department of Physical Education and Sport Sciences, National Taiwan Normal University
Study officials:
affiliation: Department of Physical Education and Sport Sciences, National Taiwan Normal University
name: Yu-Kai Chang, Ph.D.
role: STUDY_DIRECTOR
References: