Clinical trial NCT05614791: Evaluation of Pediatric Measles Cases in 2019: Single-Center Experience
Official title: Evaluation of Pediatric Measles Cases in 2019: Single-Center Experience
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Measles
Keywords: Measles
Vaccine
Children
Vitamin A
Lead sponsor: Marmara University
Sponsor class: OTHER
First posted: 2022-11-14
Enrollment: 40
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Measles case according to with clinical features and attended Pediatric Clinic between 01 January-30 June 2019

Brief summary: Measles, can be prevented and eliminated by vaccination, is a highly contagious viral disease that can lead to serious complications, disability, and death. As a result of the World Health Organization (WHO) and United Nations International Children's Emergency Fund (UNICEF) strategic plans, the annual global incidence of measles decreased by 75% over the period 2000-2015, and the estimated global mortality rate fell by 73%. For the current 2019 period, the European and the Eastern Mediterranean Region has recorded respectively more than two-fold and 1.5-fold increase in reported measles cases. As it is known, no specific antiviral treatment exists for the measles virus therefore, vaccination is still the most effective method of preventing disease.

The aim of this study was to evaluate the measles cases in districts where the refugees live quite intensely.

Detailed description: Measles, can be prevented and eliminated by vaccination, is a highly contagious viral disease that can lead to serious complications, disability, and death. As a result of the World Health Organization (WHO) and United Nations International Children's Emergency Fund (UNICEF) strategic plans, the annual global incidence of measles decreased by 75% over the period 2000-2015, and the estimated global mortality rate fell by 73%. For the current 2019 period, the European and the Eastern Mediterranean Region has recorded respectively more than two-fold and 1.5-fold increase in reported measles cases. As it is known, no specific antiviral treatment exists for the measles virus therefore, vaccination is still the most effective method of preventing disease.

The aim of this study was to evaluate the measles cases in districts where the refugees live quite intensely.

This retrospective study was consecutively enrolled children who were considered as suspicious measles case according to with clinical features and attended in Esenler Gynecology and Pediatrics Hospital Pediatric Clinic between 01 January-30 June 2019.

Eligibility criteria: Inclusion Criteria:

* The suspicious case of measles
* Measles/Rubella Case Notification and Laboratory request and result form and Measles/ Rubella Case Study form must be filled
* Accept the informed consent form
* Positive Measles Ig M and Measles Ig G laboratory test

Exclusion Criteria:

* Rejected the informed consent form

Primary outcomes:
measure: Evaluate the effect of measles vaccination status on symptom duration
timeFrame: baseline
measure: Evaluate the effect of vitamin A treatment on symptom duration
timeFrame: in the first month after the first symptom observed
Secondary outcomes:
measure: Evaluate the effect of measles vaccination status on leucocyte count
timeFrame: baseline
measure: Evaluate the effect of vitamin A treatment on leucocyte count
timeFrame: baseline
Other outcomes:
measure: Evaluate the effect of measles vaccination status on cost of measles cases
timeFrame: in the first month after the first symptom observed
measure: Evaluate the effect of vitamin A treatment on cost of measles cases
timeFrame: in the first month after the first symptom observed
Locations:
city: Istanbul
country: Turkey
facility: Esenler Maternity and Child Health Hospital
state: Esenler
city: Istanbul
country: Turkey
facility: Haseki Training and Research Hospital
Study officials:
affiliation: haseki Education and Research Hospital
name: Mahmut Caner US, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lord H, Kok J, Fletcher S, Alexander K. Is it or is it not? Lessons learned from a case of suspected vaccine strain measles. Aust N Z J Public Health. 2020 Apr;44(2):160-162. doi: 10.1111/1753-6405.12969. Epub 2020 Mar 19.
citation: Lo Vecchio A, Krzysztofiak A, Montagnani C, Valentini P, Rossi N, Garazzino S, Raffaldi I, Di Gangi M, Esposito S, Vecchi B, Melzi ML, Lanari M, Zavarise G, Bosis S, Valenzise M, Cazzato S, Sacco M, Govoni MR, Mozzo E, Cambriglia MD, Bruzzese E, Di Camillo C, Pata D, Graziosi A, Sala D, Magurano F, Villani A, Guarino A, Galli L; SITIP Measles Study Group. Complications and risk factors for severe outcome in children with measles. Arch Dis Child. 2020 Sep;105(9):896-899. doi: 10.1136/archdischild-2018-315290. Epub 2019 Jan 12.
citation: Filia A, Bella A, Del Manso M, Baggieri M, Magurano F, Rota MC. Ongoing outbreak with well over 4,000 measles cases in Italy from January to end August 2017 - what is making elimination so difficult? Euro Surveill. 2017 Sep 14;22(37):30614. doi: 10.2807/1560-7917.ES.2017.22.37.30614.