Clinical trial NCT04200820: Changing Vertical Self-motion Perception
Official title: Changing Vertical Self-motion Perception After Trampoline Jumping; Assessing Otolith Function in an Elevator
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vestibular Function Tests
Keywords: Sacculus
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2019-12-16
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The objective of this study is to explore the "vertical self-motion perception" on in healthy young individuals using an elevator as accelerator. Secondary aim is to explore the effects of repeated vertical acceleration on vertical vestibular sensibility.

Detailed description: The detection of displacement is important information to maintaining balance, postural control, and gait during daily living activities. This detection of displacement or self-motion perception is accomplished by the human vestibular system, particularly the otolith organs, the sacculus and utriculus. Both primarily respond to whole-body acceleration or tilt in gravity. The saccule and utricle detect linear motion as well as the static orientation of the head relative to gravity, which is itself a linear acceleration. The saccule is more sensitive to vertical acceleration (sensing elevator acceleration) and the utricle is more sensitive to horizontal acceleration (sensing a car accelerate). The signals from the vestibular system are transmitted o the central nervous system for further processing.

Testing the otolith function is difficult since it always a combination of the tested inertial acceleration (t) and gravity (g). Therefore the Vector of acceleration is skew. An isolated vertical direction testing of the saccule is to our knowledge not done. Testing the function of the saccule in an elevator would eliminate the any horizontal accelerations other than gravity. Using the decelerations phase of an elevator ride during both up and down ride could give important inside of the self-motion perception (sensation of acceleration of a subject). The reaction force F which accts on the otolith would be maximal when the elevator ride downwards would stop. The force acting on the otolith when the elevator got upwards is breaking is smaller than g.

A better understanding the adaption of the self-motion perception could be beneficial for patients with hypersensitive vestibular functioning, e.g. patients with vestibular migraine. We hypothesized that (a) healthy subjects change the self-motion perception after hyper-stimulation with repeated vertical acceleration.

The objective of this study is to explore the "vertical self-motion perception" on in healthy young individuals using an elevator as accelerator. Secondary aim is to explore the effects of repeated vertical acceleration on vertical vestibular sensibility.

Eligibility criteria: Inclusion Criteria:

* Healthy young adults
* Signed informed consent after being informed

Exclusion Criteria:

* Acute pain
* Chronic neck pain
* Undergone Neck surgery
* Any vestibular disorder
* Fear of elevators / claustrophobia
* Dizziness handicap inventory score \>30

Primary outcomes:
measure: Change of Vertical Self-Motion Perception Reaction Time (VSMPT)
timeFrame: Changes from before and after the elevator rides will be assessed. The assessments will be executed one minute before and after the trampoline intervention. One assessment will take 15 minutes.
Secondary outcomes:
measure: Self-administered neck mobility assessment tool (S-ROM-Neck)
timeFrame: 5 minutes. At the start of the study and before the first elevator measurements the participants are asked to fill out the questionnaire.
measure: Dizziness handicap inventory (DHI)
timeFrame: 5 minutes. At the start of the study and before the first elevator measurements the participants are asked to fill out the questionnaire.
Other outcomes:
Locations:
city: Zurich
country: Switzerland
facility: University Hospital Zurich, Directorate of Research and Education, Physiotherapy & Occupational Therapy Research
state: ZH
Study officials:
affiliation: University Hospital Zurich, Directorate of Research and Education
name: Jaap Swanenburg, PhD
role: PRINCIPAL_INVESTIGATOR
References: