louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01853904: Utility of Syringe Based Suction Versus Channel Suction in Bronchoalveolar Lavage
Official title: Utility of Syringe Based Suction Versus Channel Suction in Bronchoalveolar Lavage
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bronchoscopy
Keywords: Bronchoscopy
BAL
Suction
Lead sponsor: University of Oklahoma
Sponsor class: OTHER
First posted: 2013-05-15
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Bronchoalveolar lavage (BAL) is a common technique among pulmonologists. Its goal is to collect cells from alveolar units. This is done by wedging a flexible bronchoscope in a bronchus, instilling saline, and removing the saline via suction. Two techniques are currently used for suctioning: syringe based and channel suction.

The investigators concern is that channel suction creates too much force and there is collapsing of the airways which results in decreased fluid removal as well as cell sampling. The investigators propose that syringe based suctioning will not only return more of the instilled fluid but also more cells from the alveoli.

Detailed description: The pulmonary segment with the most disease on imaging will be the segment sampled. The scope will be wedged in the airway leading to that segment and 100mL of saline will be instilled into the selected segment and collected via the syringe based or channel based suction. Prior to unwedging, another 100mL of saline will be instilled into the same segment and will be collected using the alternative method. There will not be randomization, but the investigators will alternate which method is used first to eliminate confounding variables. All patients will receive both modalities of suctioning. The wall suction used for the channel suction will be set at 80 mm Hg. Syringe based suctioning will be performed with 20mL syringe. Total amount of fluid collected will be recorded and samples will be sent for cell count and differential as well as Gram stain and culture. Results of the two techniques will then be compared to determine which is the superior suctioning modality for BAL.

Eligibility criteria: Inclusion Criteria:

* Bronchoscopy scheduled

Exclusion Criteria:

* None

Primary outcomes:
measure: Efficacy of Syringe Suction versus Channel Suction to retrieve volume
timeFrame: 24 hours
Secondary outcomes:
measure: Efficacy of Syringe suction versus Channel suction to retrieve alveolar cells
timeFrame: 24 hours
Other outcomes:
Locations:
city: Oklahoma City
country: United States
facility: OUHSC
state: Oklahoma
Study officials:
affiliation: OUHSC
name: Brent Brown, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00309504: Pulse Sequence Development on 3T Magnetic Resonance Imaging/Spectroscopy
Official title: Pulse Sequence Development on 3T Magnetic Resonance Imaging/Spectroscopy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: magnetic resonance imaging
magnetic resonance spectroscopy
Lead sponsor: AHS Cancer Control Alberta
Sponsor class: OTHER
Collaborators: name: Cross Cancer Institute
First posted: 2006-04-03
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Local Healthy volunteers

Brief summary: The purpose of this study is to find ways to improve the appearance of tumours or markers that indicate the presence of tumours in Magnetic Resonance Imaging (MRI). Although based on the same technology, there are many ways to obtain images using MRI. The type of image that will be produced by the scanner depends on the instructions sent to the machine. These instructions tell different components of the machine when to turn on and off and all together are called a pulse sequence. These pulse sequences can get quite lengthy and intricate and small changes in them can produce considerable changes in the resulting image. the aim of this protocol is to alter existing pulse sequences to improve image appearance. This protocol will involve only healthy volunteers.


Eligibility criteria: Inclusion Criteria:

* healthy adult

Exclusion Criteria:

* subject under 18 years of age
* subject pregnant, or may be pregnant

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Edmonton
country: Canada
facility: Cross Cancer Institute
state: Alberta
Study officials:
affiliation: AHS Cancer Control Alberta
name: Gino B. Fallone, PhD, FCCPH, DABR
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00000104: Does Lead Burden Alter Neuropsychological Development?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lead Poisoning
Keywords: lead overburden
Lead sponsor: National Center for Research Resources (NCRR)
Sponsor class: NIH
Collaborators: name: HRSA/Maternal and Child Health Bureau
First posted: 1999-11-04
Sex: FEMALE
Minimum age (years): 0
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: DEFINED_POPULATION
Time perspective: OTHER

Brief summary: Inner city children are at an increased risk for lead overburden. This in turn affects cognitive functioning. However, the underlying neuropsychological effects of lead overburden and its age-specific effects have not been well delineated. This study is part of a larger study on the effects of lead overburden on the development of attention and memory. The larger study is using a multi-model approach to study the effects of lead overburden on these effects including the event-related potential (ERP), electrophysiologic measures of attention and memory are studied. Every eight months, for a total of three sessions the subjects will complete ERP measures of attention and memory which require them to watch various computer images while wearing scalp electrodes recording from 11 sites. It is this test that we are going to be doing on CRC. There will be 30 lead overburdened children recruited from the larger study for participation in the ERP studies on CRC. These 30 children will be matched with 30 children without lead overburden. This portion of the study is important in providing an index of physiological functioning to be used along with behaviorally based measures of attention and memory, and for providing information about the different measures.


Eligibility criteria: Inclusion Criteria:

* Pregnant mothers of the Phillips neighborhood in Minneapolis, Minnesota. Subject recruitment will take place in local clinics which serve pregnant women and offspring

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Minneapolis
country: United States
facility: Department of Neurology 420 Delaware St. SE, Box 486 Mayo
state: Minnesota
Study officials:
References:
Clinical trial NCT02982304: Multi-Target Pallidal and Thalamic Deep Brain Stimulation for Hemi-Dystonia
Official title: Multi-Target Pallidal and Thalamic Deep Brain Stimulation for Hemi-Dystonia
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Dystonia
Dystonia, Secondary
Lead sponsor: University of British Columbia
Sponsor class: OTHER
First posted: 2016-12-05
Enrollment: 4
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Dystonia is increasingly being considered as a multi-nodal network disorder involving both basal ganglia and cerebellar dysfunction. The aim of this study is to determine if "Multi-Target" Thalamic and Pallidal Deep Brain Stimulation improves hemi-dystonia patients who are receiving inadequate therapy from GPi DBS.


Eligibility criteria: Inclusion Criteria:

1. Diagnosed with hemi-dystonia secondary to stroke
2. Candidate for GPi DBS
3. Able to provide informed consent

Exclusion Criteria:

1. History of intracranial pathology (such as multiple sclerosis, tumors, or aneurysms) that may account for dystonia or essential tremor.
2. History or evidence of ongoing psychiatric or neurodegenerative disorders (such as Parkinson's disease, Alzheimer's disease).
3. Incompetent adults or those unable to communicate.

Primary outcomes:
measure: Burke Fahn Marsden Disability Rating Scale (BFMDRS)
timeFrame: 3 months
measure: SF-36 Quality of Life Scale
timeFrame: 3 months
measure: Adverse effects of Vim or Vim + GPi Neuromodulation
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Vancouver
country: Canada
facility: Vancouver General Hospital
state: British Columbia
Study officials:
affiliation: University of British Columbia
name: Chris Honey, MD,DPhil,FRCSC
role: PRINCIPAL_INVESTIGATOR
References:
citation: Slotty PJ, Poologaindran A, Honey CR. A prospective, randomized, blinded assessment of multitarget thalamic and pallidal deep brain stimulation in a case of hemidystonia. Clin Neurol Neurosurg. 2015 Nov;138:16-9. doi: 10.1016/j.clineuro.2015.07.012. Epub 2015 Jul 29.
citation: Prudente CN, Hess EJ, Jinnah HA. Dystonia as a network disorder: what is the role of the cerebellum? Neuroscience. 2014 Feb 28;260:23-35. doi: 10.1016/j.neuroscience.2013.11.062. Epub 2013 Dec 11.
Clinical trial NCT04310904: Cardiac Output Assessment by Using Saline Contrast Injection
Official title: Cardiac Output Assessment by Using Saline Contrast Injection
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Echocardiography
Keywords: echocardiography
Doppler cardiac output
contrast
thermodilution
agitated saline
ICU
Lead sponsor: Centre Hospitalier Universitaire, Amiens
Sponsor class: OTHER
First posted: 2020-03-17
Enrollment: 65
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: all ICU patients intubated/ventilated with a central line and an arterial catheter who need trans esophageal echocardiography examination with a saline contrast test.

Brief summary: Cardiac output (CO) assessment is one of the cornerstone of hemodynamic evaluation in ICU patients. CO is usually measured using invasive methods or non-invasive methods. Thermodilution is considered as the gold standard for CO assessment. Cardiac Doppler as well demonstrated to be accurate but needs manipulations and good knowledge and skills. The investigators developed a new technique using injection of agitated saline solution to evaluate CO without any manual measurement and then observer independent.

Detailed description: The investigators decided to conduct a prospective observational study to compare contrast assessment of CO and cardiac Doppler technique. Patients hospitalized in ICU will be included if they need a trans esophageal echocardiographic evaluation and a research of intra cardiac shunt (using a saline contrast test). Patients with Swan Ganz catheter will be included as well. Cardiac output will be measured using cardiac Doppler. Simultaneously, 4.5 ml of saline with 0.5 ml of air will be agitated to have a contrast solution. This solution will be injected as usual and echocardiographic imaging will be recorded. These imaging will be analyzed off-line and CO will be calculated with an algorithm previously developed and compared with the reference method. In case of swan ganz catheter, the cardiac output will be also measured using the thermodilution technique.

Eligibility criteria: Inclusion Criteria:

* all ICU patients intubated/ventilated with a central line and an arterial catheter who need trans esophageal echocardiography examination with a saline contrast test.

Exclusion Criteria:

* patients under 18 years old
* pregnant patients
* moribund patients

Primary outcomes:
measure: variation of cardiac output assessment (CO)
timeFrame: day 0
Secondary outcomes:
measure: variation of cardiac output assessment (CO) in patients with a swan gaz catheter
timeFrame: day 0
Other outcomes:
Locations:
city: Amiens
country: France
facility: CHU Amiens
Study officials:
References:
Clinical trial NCT02311504: Eye Screening in German Secondary Diabetes Care Centers
Official title: OCT Screening of Diabetes Patients: Health Care Research in Secondary Diabetes Care Centers
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Diabetic Retinopathy
Lead sponsor: University Hospital Tuebingen
Sponsor class: OTHER
First posted: 2014-12-08
Enrollment: 831
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with diabetes in secondary care diabetes centers

Brief summary: In patients with confirmed diagnosis of diabetes, an eye examination and a comprehensive survey are conducted after recruitment in secondary diabetes care centers. All patients undergo a comprehensive eye examination including wide-angle fundus photograph and ocular cohaerence tomography. A questionnaire assesses the characteristics (history: diabetes duration, type of treatment), knowledge and personal attitudes of the persons affected. The relevant lab findings were collected from the electronic files.

Main focus of the study is the concordance to the national screening recommendations (last eye exam, presence of retinopathy).


Eligibility criteria: Inclusion Criteria:

- diabetes

Exclusion Criteria:

* mental handicap
* in the case of blindness absence of a caregiver

Primary outcomes:
measure: presence of diabetic retinopathy
timeFrame: day
Secondary outcomes:
Other outcomes:
Locations:
city: Tuebingen
country: Germany
facility: University Eye Hospital
state: BW
Study officials:
References:
citation: Marahrens L, Ziemssen F, Fritsche A, Ziemssen T, Kern R, Martus P, Roeck D. Limited Time from the Diabetes Patients' Perspective: Need for Conversation with the Eye Specialist. Ophthalmologica. 2016;236(3):154-158. doi: 10.1159/000450708. Epub 2016 Oct 5.
Clinical trial NCT03831204: Systolic Time Intervals a Prognostic Tool of Heart Failure in Emergency Departement (STI/AHF)
Official title: Systolic Time Intervals a Pronostic Tool of Heart Failure in Emergency Departement
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dyspnea
Heart Failure
Keywords: impedance
dyspnea
AHF
BNP
EFFECT
GWTG-HF
Lead sponsor: University of Monastir
Sponsor class: OTHER
First posted: 2019-02-05
Enrollment: 642
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: all patients aged more than 18 years admitted to the ED with the diagnosis of acute decompensated heart failure

Brief summary: The performance of STIs and clinical scores alone and their combination to predict short term prognosis of acute decompensated heart failure.

Detailed description: Acute heart failure is a leading cause of hospitalization and death.Prediction of these adverse events is still challenging.

STI is an old technique based on the recording of two parameters: electrocardiogram and phonocardiogram, and from them measuring the different systolic intervals:

pre-ejection period (PEP),electro-mechanic activation time (EMAT), Left ventricular ejection time (LVET) and systolic time ratio (RTS) were measured.

The aim of these study is to demonstrate whether systolic time intervals (STIs) can improve clinical scores EFFECT (Enhanced Feedback for Effective Cardiac Treatment) and GWTG-HF (Get With the Guidelines-Heart Failure) for predicting 30 day mortality and readmission in patients with acute decompensated heart failure (ADHF) in the ED.

Eligibility criteria: Inclusion Criteria:

* non traumatic dyspnea
* age more than 18 years old.

Exclusion Criteria:

* ECG diagnostic for acute myocardial infarction
* ischemic chest pain within the prior 24 hours
* history of a heart transplant
* pericardial effusion
* chest wall deformity suspected of causing dyspnea
* coma
* shock,Mechanical Ventilation, vasopressor drugs
* arrhythmia serious and sustained,
* pace maker
* severe mitral valve disease,
* severe pulmonary arterial hypertension
* renal failure with creatinine \>350micromol/l

Primary outcomes:
measure: compare the STIs prognostic performance against clinical scores
timeFrame: 30 days
Secondary outcomes:
measure: compare the STI prognostic performance between HFpEF and HFrEF patients
timeFrame: 30 days
Other outcomes:
Locations:
city: Monastir
country: Tunisia
facility: Emergency department of university hospital Fattouma Bourguiba of Monastir Monastir, Monastir Tunisia
Study officials:
affiliation: University hospital of Monastir
name: Nouira Semir, Pr
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01198704: Study of Factors Predicting Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma (HCC)
Official title: Study of Factors Predicting Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hepatocellular Carcinoma
Liver Cirrhosis
Evidence of Liver Transplantation
Keywords: Hepatocellular carcinoma
Cirrhosis
Transplantation
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2010-09-10
Enrollment: 372
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient notified on the waiting list for hepatic transplant

Brief summary: Results of liver transplantation, the best theoretical treatment for HCC, are limited by tumor recurrence. In order to limit this risk Milan criteria was proposed in 1996. However, these criteria are to restrictive and approximately 40% of patients denied by Milan criteria may be cured by liver transplantation.

The purpose of this study was thus to prospectively evaluate factors predicting tumor recurrence after liver transplantation for HCC and then to reassess criteria for liver transplantation.

Detailed description: In this study, the investigators studied the predictive value of imaging techniques such as CT, MRI, PET scan, of serological markers and molecular markers assessed before liver transplantation at listing.

The investigators also evaluated the predictive value of tumor growing during the waiting time (imaging and serological).

Finally, the investigators compared pre-LT data and explanted liver analysis to evaluate accuracy of liver biopsy and of imaging.

Eligibility criteria: Inclusion Criteria:

* Liver cirrhosis
* Hepatocellular carcinoma diagnosed by AASLD criteria or liver biopsy
* Listing for Liver transplantation for HCC fulfilling or not Milan criteria
* No extra-hepatic spread
* No vascular involvement

Exclusion Criteria:

* Salvage transplantation
* Transplantation contra-indication
* Evaluation for Liver transplantation older than 1 month
* Incidental HCC

Primary outcomes:
measure: Predictive factors of HCC recurrence
timeFrame: at 2 years after Liver transplantation for HCC (modified by amendment on 17/10/2013)
Secondary outcomes:
measure: Predictive factors of tumor-free recurrence
timeFrame: at 3 years
measure: Predictive factors of overall survival at 5 years
timeFrame: at 5 years
measure: Predictive factors of drop-out
timeFrame: during the waiting time
measure: Radio-pathological correlation
timeFrame: end of the study
measure: Correlation of HCC differentiation between liver biopsy and explant liver
timeFrame: at 32 month
Other outcomes:
Locations:
city: Grenoble
country: France
facility: Clinique Universitaire d'Hépato-gastroentérologie
Study officials:
affiliation: University Hospital, Grenoble
name: Thomas Decaens, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01262404: Imaging Cerebral and Sub-cerebral Correlates of Meditative States
Official title: Imaging Cerebral and Sub-cerebral Correlates of Meditative States
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Stress
Lead sponsor: Boston University
Sponsor class: OTHER
Collaborators: name: Emory University
First posted: 2010-12-17
Enrollment: 58
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Community Sample

Brief summary: Three groups of subjects are trained to practice mindfulness meditation, compassion meditation, or attend a health training control class. Individuals from each group will undergo structural and functional brain imaging before and after training. The hypothesis is that the compassion meditation group will show the largest changes in brain structure and function. In a second series of experiments, the subjects practicing a Tibetan meditation practice will be undergo MRI thermometry imaging to construct detailed three dimensional temperature maps of their bodies before, during, and after they perform this practice.

Detailed description: Structural (MRI) Imaging will be used to measure changes in cortical thickness in the pre and post training groups. Function (fMRI) Imaging will be used to measure changes in cortical and sub-cortical responses to a series of affectively controlled visual images, presented during scanning. MRI Thermometry Imaging will be used to construct three dimensional temperature maps of subjects while performing meditation in the scanner.

Eligibility criteria: Inclusion Criteria:

* Age 18-65 for the mindfulness-compassion study
* Prior training in gtummo meditation for the gtummo study

Exclusion Criteria:

* Previous experience with meditation for the mindfulness-compassion study

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: Boston University Dept. of Cognitive and Neural Systems
state: Massachusetts
Study officials:
affiliation: Boston University
name: Eric L Schwartz, PhD
role: PRINCIPAL_INVESTIGATOR
References: