Clinical trial NCT01883674: Milk and Milk-produce to Counteract the Loss of Muscle Mass and Function in Exercising Older Adults.
Official title: Milk and Milk-produce to Counteract the Loss of Muscle Mass and Function in Exercising Older Adults.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sarcopenia
Keywords: Sarcopenia
Physical capacity
Muscle force
Muscle quality
Milk proteins
Essential amino acids
Proteins
Resistance training
Exercise
Lead sponsor: Université de Sherbrooke
Sponsor class: OTHER
Collaborators: name: Dairy Farmers of Canada
First posted: 2013-06-21
Enrollment: 41
Sex: MALE
Minimum age (years): 65
Maximum age (years): 75
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This project evaluates the use of different types of proteins from various food sources after an exercise session, on muscle mass and physical capacity in aged sarcopenic men (who have low muscle mass). Specifically, researchers want to:

* Examine the efficiency of protein intake after exercise on muscle mass and physical abilities;
* Examine the impact of exercise and proteins on blood lipids (LDL cholesterol, HDL cholesterol, total cholesterol and triglycerides);
* Examine the impact of exercise and proteins on liver enzymes;
* Examine the impact of exercise and proteins on a hormone that controls hunger;
* Evaluate the program's impact on the ability of the body to produce energy.

All participants are exercising (resistance training) and ingest one of the 3 different sources of proteins, immediately after training:

* Milk proteins (from milk beverage)
* Essential amino acids (added to a soya beverage)
* No protein (rice beverage - control group)

Our hypothesis is that proteins from milk will induce a gain in muscle mass and physical function equivalent to the essential amino acids (EAA). We anticipate that both milk proteins and EAA will be both superior to control group.

This would represent an interesting finding since milk is more accessible, palatable and cheaper than essential amino acids commercial mix.


Eligibility criteria: Inclusion Criteria:

* 65-75 years
* francophone or understanding French
* muscle mass index \< 10.75 kg/m2 (Janssen et al, 2004)
* body mass index \<30kg/m²
* weight stable (\< 2 kg) for 6 mo
* no resistance exercise for 3 years
* controlled blood pressure for at least 6 months

Exclusion Criteria:

* major physical disability
* medical treatment influencing metabolism
* statin treatment
* diagnosis or any sign of kidney disease

Primary outcomes:
measure: Muscle mass
timeFrame: At baseline and post intervention (17th week)
Secondary outcomes:
measure: Relative strength
timeFrame: At baseline and post intervention (17th week)
measure: Blood markers of inflammation
timeFrame: At baseline and post intervention (17th week)
measure: Plasma Lipid profile
timeFrame: At baseline and post intervention (17th week)
measure: Plasma creatinine
timeFrame: At baseline, mid (8th week) and post intervention (17th week)
measure: Blood markers of fatty liver
timeFrame: At baseline and post intervention (17th week)
measure: extracellular HSP72
timeFrame: At baseline and post intervention (17th week)
Other outcomes:
measure: Dietary intakes
timeFrame: At baseline, mid (8th week) and post intervention (17th week)
measure: Physical activity level
timeFrame: At baseline and post intervention (17th week)
Locations:
city: Sherbrooke
country: Canada
facility: Centre de recherche sur le vieillissement
state: Quebec
Study officials:
affiliation: Université de Sherbrooke
name: Isabelle J. Dionne, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: