Clinical trial NCT03653026: A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Ulcerative Colitis
Official title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study to Evaluate the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Moderately to Severely Active Ulcerative Colitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Ulcerative Colitis (UC)
Keywords: Upadacitinib
ABT-494
Ulcerative Colitis
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2018-08-31
Enrollment: 522
Sex: ALL
Minimum age (years): 16
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo in inducing clinical remission (per Adapted Mayo score) in participants with moderately to severely active ulcerative colitis (UC).

Detailed description: Study M14-675 consists of 2 parts, Part 1 and Part 2. Part 1 is a randomized, double-blind, placebo-controlled 8-week induction period. Part 2 is an open-label, 8-week extended treatment period for participants who did not achieve clinical response at Week 8 in Part 1.

Eligible participants are randomized in a 2:1 ratio to one of the two treatment groups (upadacitinib 45 mg or matching placebo) for 8 weeks. The randomization is stratified by biologic inadequate responder (bio-IR) status (bio-IR vs non-bio-IR), corticosteroid use (yes or no), and Adapted Mayo score (≤ 7 or \> 7) at Baseline. Within bio-IR, the randomization is further stratified by number of prior biologic treatments (≤ 1 or \> 1). Within non-bio-IR, the randomization is further stratified by previous biologic use (yes or no).

Participants who achieve clinical response defined by Adapted Mayo Score at Week 8 or Week 16 and do not meet any study discontinuation criteria are eligible to enroll into Study M14-234 Substudy 3 (NCT02819635; 52-week maintenance study) or Study M14-533 Cohort 1 (NCT03006068; long-term follow-up study).

Eligibility criteria: Inclusion Criteria:

- Male or female participants ≥ 16 and ≤ 75 years of age at Baseline Note: Adolescent participants at the age of 16 or 17 years old will be eligible to participate if approved by the country or regulatory/health authorities.

Note: Adolescent participants at the age of 16 or 17 years old must weigh ≥ 40 kilograms and meet the definition of Tanner Stage 5 at the Screening Visit.

* Diagnosis of Ulcerative Colitis (UC) for 90 days or greater prior to Baseline, confirmed by colonoscopy during the Screening Period, with exclusion of current infection, colonic dysplasia and/or malignancy. Appropriate documentation of biopsy results consistent with the diagnosis of UC, in the assessment of the Investigator, must be available.
* Active UC with an Adapted Mayo score of 5 to 9 points and endoscopic subscore of 2 to 3.
* Demonstrated an inadequate response, loss of response, or intolerance to at lease one of the following treatments including, oral aminosalicylates, corticosteroids, immunosuppressants, and/or biologic therapies.

Note: Participants who have had inadequate response, loss of response to conventional therapy but have not failed biologic therapy (Non-bio-IR) and have received a prior biologic for up to 1 year may be enrolled, however they must have discontinued the biologic for reasons other than inadequate response or intolerance (e.g., change of insurance, well controlled disease), and must meet criteria for inadequate response, loss of response, or intolerance as defined above.

* Female Participants of childbearing potential must have a negative serum pregnancy test at the Screening Visit and a negative urine pregnancy test at the Baseline Visit.
* If female, participant must meet the contraception recommendation criteria.

Exclusion Criteria:

* Participant with current diagnosis of Crohn's disease (CD) or diagnosis of indeterminate colitis (IC).
* Current diagnosis of fulminant colitis and/or toxic megacolon.
* Participant with disease limited to the rectum (ulcerative proctitis) during the Screening endoscopy.
* Received cyclosporine, tacrolimus, mycophenolate mofetil, or thalidomide within 30 days prior to Baseline.
* Participant who received azathioprine or 6-mercaptopurine (6-MP) within 10 days of Baseline.
* Received intravenous corticosteroids within 14 days prior to Screening or during the Screening Period.
* Participant with previous exposure to Janus Activated Kinase (JAK) inhibitor (e.g., tofacitinib, baricitinib, filgotinib, upadacitinib).
* Screening laboratory and other analyses show any prespecified abnormal hematologic results.

Primary outcomes:
measure: Percentage of Participants Who Achieved Clinical Remission Per Adapted Mayo Score at Week 8
timeFrame: Week 8
Secondary outcomes:
measure: Percentage of Participants With Endoscopic Improvement at Week 8
timeFrame: Week 8
measure: Percentage of Participants With Endoscopic Remission at Week 8
timeFrame: Week 8
measure: Percentage of Participants Who Achieved Clinical Response Per Adapted Mayo Score at Week 8
timeFrame: Week 8
measure: Percentage of Participants Who Achieved Clinical Response Per Partial Adapted Mayo Score at Week 2
timeFrame: Week 2
measure: Percentage Of Participants Who Achieved Histologic-Endoscopic Mucosal Improvement at Week 8
timeFrame: Week 8
measure: Percentage of Participants Who Reported No Bowel Urgency at Week 8
timeFrame: Week 8
measure: Percentage of Participants Who Reported No Abdominal Pain at Week 8
timeFrame: Week 8
measure: Percentage of Participants Who Achieved Histologic Improvement at Week 8
timeFrame: Week 8
measure: Change From Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score at Week 8
timeFrame: Baseline (Week 0) to Week 8
measure: Percentage of Participants Who Achieved Mucosal Healing at Week 8
timeFrame: Week 8
measure: Change From Baseline in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Score at Week 8
timeFrame: Baseline (Week 0) to Week 8
Other outcomes:
Locations:
city: Mobile
country: United States
facility: East View Medical Research, LLC /ID# 216933
state: Alabama
city: Mobile
country: United States
facility: CB Flock Research Corporation /ID# 206094
state: Alabama
city: Sun City
country: United States
facility: Arizona Arthritis & Rheumatology Research, PLLC /ID# 211030
state: Arizona
city: Tempe
country: United States
facility: Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211887
state: Arizona
city: Tucson
country: United States
facility: University of Arizona /ID# 208856
state: Arizona
city: Covina
country: United States
facility: Citrus Valley Gastroenterology /ID# 205627
state: California
city: Huntington Beach
country: United States
facility: Care Access Research /ID# 217003
state: California
city: La Jolla
country: United States
facility: Moore UC San Diego Cancer Center /ID# 204919
state: California
city: Los Alamitos
country: United States
facility: United Medical Doctors /ID# 207867
state: California
city: Los Angeles
country: United States
facility: TLC Clinical Research Inc /ID# 216831
state: California
city: Los Angeles
country: United States
facility: Gastrointestinal Biosciences Clinical Trials, LLC /ID# 205314
state: California
city: Mission Hills
country: United States
facility: Facey Medical Foundation /ID# 205301
state: California
city: Murrieta
country: United States
facility: United Medical Doctors - Murrieta /ID# 205313
state: California
city: Oxnard
country: United States
facility: InSite Digestive Health Care - Oxnard /ID# 205628
state: California
city: Rialto
country: United States
facility: Inland Empire Clinical Trials, LLC /ID# 216164
state: California
city: San Diego
country: United States
facility: San Diego Clinical Trials /ID# 212122
state: California
city: San Diego
country: United States
facility: Medical Assoc Research Grp /ID# 205626
state: California
city: Colorado Springs
country: United States
facility: Delta Waves, Inc. /ID# 206170
state: Colorado
city: Wheat Ridge
country: United States
facility: Western States Clinical Res /ID# 206091
state: Colorado
city: Danbury
country: United States
facility: Western Connecticut Medical Group /ID# 208290
state: Connecticut
city: Hamden
country: United States
facility: Gastroenterology Center of CT /ID# 208291
state: Connecticut
city: Clearwater
country: United States
facility: Gastro Florida /ID# 206174
state: Florida
city: Doral
country: United States
facility: Universal Axon Clinical Research /ID# 213462
state: Florida
city: Hialeah
country: United States
facility: Palmetto Research, LLC /ID# 208293
state: Florida
city: Inverness
country: United States
facility: Nature Coast Clinical Research - Inverness /ID# 206087
state: Florida
city: Jacksonville
country: United States
facility: Encore Borland-Groover Clinical Research /Id# 208128
state: Florida
city: Maitland
country: United States
facility: Cfagi Llc /Id# 207995
state: Florida
city: Miami
country: United States
facility: University of Miami /ID# 215445
state: Florida
city: Miami
country: United States
facility: Coral Research Clinic /ID# 208292
state: Florida
city: New Port Richey
country: United States
facility: Advanced Research Institute, Inc /ID# 206077
state: Florida
city: Orlando
country: United States
facility: Endoscopic Research, Inc. /ID# 207360
state: Florida
city: Orlando
country: United States
facility: Omega Research Consultants /ID# 206066
state: Florida
city: Tampa
country: United States
facility: Clinical Research Trials of Florida, Inc. /ID# 206068
state: Florida
city: Tampa
country: United States
facility: University of South Florida /ID# 214495
state: Florida
city: Tampa
country: United States
facility: AdventHealth Tampa /ID# 207363
state: Florida
city: Macon
country: United States
facility: Gastroenterology Associates of Central Georgia, LLC /ID# 216940
state: Georgia
city: Riverdale
country: United States
facility: Infinite Clinical Trials /ID# 215343
state: Georgia
city: Suwanee
country: United States
facility: Atlanta Gastroenterology Spec /ID# 206173
state: Georgia
city: Chicago
country: United States
facility: Next Innovative Clinical Research - Chicago /ID# 217324
state: Illinois
city: Chicago
country: United States
facility: The University of Chicago Medical Center /ID# 206172
state: Illinois
city: Effingham
country: United States
facility: Carle Foundation Hospital /ID# 207397
state: Illinois
city: Evansville
country: United States
facility: MediSphere Medical Research Center /ID# 206073
state: Indiana
city: Indianapolis
country: United States
facility: Indianapolis Gastroenterology /ID# 206381
state: Indiana
city: Iowa City
country: United States
facility: University of Iowa Hospitals and Clinics /ID# 206167
state: Iowa
city: Topeka
country: United States
facility: Cotton-O'Neil Clinical Res Ctr /ID# 206175
state: Kansas
city: Crestview Hills
country: United States
facility: Tri-State Gastroenterology /ID# 206124
state: Kentucky
city: Houma
country: United States
facility: Houma Digestive Health Special /ID# 206176
state: Louisiana
city: Shreveport
country: United States
facility: Louisana Research Center, LLC /ID# 206064
state: Louisiana
city: Columbia
country: United States
facility: Gastro Center of Maryland /ID# 206883
state: Maryland
city: Ann Arbor
country: United States
facility: University of Michigan Health Systems /ID# 206918
state: Michigan
city: Ann Arbor
country: United States
facility: Huron Gastroenterology Assoc /ID# 205109
state: Michigan
city: Chesterfield
country: United States
facility: Clin Res Inst of Michigan, LLC /ID# 207078
state: Michigan
city: Southfield
country: United States
facility: Revival Research Institute, LLC /ID# 207282
state: Michigan
city: Troy
country: United States
facility: Center for Digestive Health /ID# 207080
state: Michigan
city: Rochester
country: United States
facility: Mayo Clinic /ID# 205645
state: Minnesota
city: Jackson
country: United States
facility: University of Mississippi Medical Center /ID# 213116
state: Mississippi
city: Jackson
country: United States
facility: Southern Therapy and Advanced Research (STAR) LLC /ID# 206069
state: Mississippi
city: Las Vegas
country: United States
facility: Las Vegas Medical Research /ID# 206814
state: Nevada
city: Egg Harbor Township
country: United States
facility: AGA Clinical Research Associates, LLC /ID# 206880
state: New Jersey
city: Morristown
country: United States
facility: Atlantic Digestive Health Inst /ID# 208748
state: New Jersey
city: New Brunswick
country: United States
facility: Rutgers Robert Wood Johnson /ID# 207382
state: New Jersey
city: Albuquerque
country: United States
facility: University of New Mexico Department of Internal Medicine /ID# 214397
state: New Mexico
city: Bronx
country: United States
facility: Advantage Clinical Trials /ID# 206082
state: New York
city: Brooklyn
country: United States
facility: NY Scientific /ID# 206080
state: New York
city: Lake Success
country: United States
facility: NYU Langone Long Island Clinical Research Associates /ID# 206079
state: New York
city: North Massapequa
country: United States
facility: DiGiovanna Institute for Medical Education & Research /ID# 206885
state: New York
city: Poughkeepsie
country: United States
facility: Premier Medical Group - GI Division /ID# 206097
state: New York
city: Rochester
country: United States
facility: Gastro Group of Rochester /ID# 206881
state: New York
city: Staten Island
country: United States
facility: Richmond University Medical Center /ID# 213185
state: New York
city: Asheville
country: United States
facility: Digestive Health Partners, P.A /ID# 206842
state: North Carolina
city: Charlotte
country: United States
facility: Atrium Health Carolinas Medical Center /ID# 206085
state: North Carolina
city: Charlotte
country: United States
facility: Charlotte Gastroenterology and Hepatology, PLLC /ID# 206138
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest Baptist Medical Center /ID# 206067
state: North Carolina
city: Fargo
country: United States
facility: Duplicate_Plains Clinical Research Center, LLC /ID# 205111
state: North Dakota
city: Cincinnati
country: United States
facility: University of Cincinnati /ID# 205633
state: Ohio
city: Columbus
country: United States
facility: The Ohio State University /ID# 205637
state: Ohio
city: Columbus
country: United States
facility: Optimed Research, Ltd. /ID# 205638
state: Ohio
city: Dayton
country: United States
facility: Hometown Urgent Care and Resea /ID# 205630
state: Ohio
city: Englewood
country: United States
facility: Dayton Gastroenterology, Inc. /ID# 205639
state: Ohio
city: Mentor
country: United States
facility: Great Lakes Gastroenterology Research LLC /ID# 205631
state: Ohio
city: Oklahoma City
country: United States
facility: Hightower Clinical /ID# 216336
state: Oklahoma
city: Oklahoma City
country: United States
facility: Digestive Disease Specialists /ID# 206076
state: Oklahoma
city: Tulsa
country: United States
facility: Options Health Research, LLC /ID# 206707
state: Oklahoma
city: Tulsa
country: United States
facility: Healthcare Research Consultant /ID# 206706
state: Oklahoma
city: Sayre
country: United States
facility: Guthrie Medical Group, PC /ID# 206078
state: Pennsylvania
city: Charleston
country: United States
facility: Pharmacorp Clinical Trials /ID# 206074
state: South Carolina
city: Greenville
country: United States
facility: Gastroenterology Associates, P.A. of Greenville /ID# 206098
state: South Carolina
city: Germantown
country: United States
facility: Gastro One /ID# 206178
state: Tennessee
city: Johnson City
country: United States
facility: East Tennessee Research Institute /ID# 206169
state: Tennessee
city: Nashville
country: United States
facility: Quality Medical Research /ID# 206088
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center /ID# 210405
state: Tennessee
city: Arlington
country: United States
facility: TX Clinical Research Institute /ID# 206718
state: Texas
city: Baytown
country: United States
facility: Inquest Clinical Research /ID# 206132
state: Texas
city: Cedar Park
country: United States
facility: Texas Digestive Disease Consultants /ID# 209805
state: Texas
city: Cedar Park
country: United States
facility: Texas Digestive Disease Consultants /ID# 209948
state: Texas
city: Dallas
country: United States
facility: Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 207484
state: Texas
city: Garland
country: United States
facility: DHAT Research Institute /ID# 206716
state: Texas
city: Houston
country: United States
facility: Vilo Research Group Inc /ID# 212625
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine - Baylor Medical Center /ID# 206717
state: Texas
city: Houston
country: United States
facility: Centex Studies, Inc. - Houston /ID# 206168
state: Texas
city: Houston
country: United States
facility: GI Specialists of Houston /ID# 206090
state: Texas
city: Lubbock
country: United States
facility: Caprock Gastro Research /ID# 215115
state: Texas
city: San Antonio
country: United States
facility: Clinical Associates in Research Therapeutics of America, LLC /ID# 206710
state: Texas
city: San Antonio
country: United States
facility: Southern Star Research Institute, LLC /ID# 205379
state: Texas
city: Temple
country: United States
facility: Baylor Scott & White Center for Diagnostic Medicine /ID# 206096
state: Texas
city: Tyler
country: United States
facility: Duplicate_Tyler Research Institue /ID# 206075
state: Texas
city: Victoria
country: United States
facility: Gastro Health & Nutrition - Victoria /ID# 205378
state: Texas
city: Ogden
country: United States
facility: Advanced Research Institute /ID# 206133
state: Utah
city: Franklin
country: United States
facility: Ctr for Gastrointestinal Healt /ID# 208475
state: Virginia
city: Bellevue
country: United States
facility: Washington Gastroenterology Associates /ID# 206177
state: Washington
city: Seattle
country: United States
facility: Virginia Mason - Seattle Orthapedics /ID# 206070
state: Washington
city: Vancouver
country: United States
facility: The Vancouver Clinic, INC. PS /ID# 204973
state: Washington
city: Milwaukee
country: United States
facility: Wisconsin Center for Advanced Research, a division of GI Associates, LLC /ID# 206917
state: Wisconsin
city: Milwaukee
country: United States
facility: Froedtert Memorial Lutheran Hospital /ID# 206945
state: Wisconsin
city: San Isidro
country: Argentina
facility: Cardio Alem /ID# 211282
state: Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Mautalen Salud e Investigacion /ID# 206033
state: Ciuadad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Hospital Britanico de Buenos Aires /ID# 209497
state: Ciuadad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Gedyt /ID# 210017
state: Ciuadad Autonoma De Buenos Aires
city: Cordoba
country: Argentina
facility: Hospital Privado Univesitario /ID# 206030
city: Macquarie University
country: Australia
facility: Macquarie University Hospital /ID# 211955
state: New South Wales
city: South Brisbane
country: Australia
facility: Duplicate_Mater Misericordiae /ID# 212687
state: Queensland
city: Southport
country: Australia
facility: Griffith University /ID# 211956
state: Queensland
city: Fitzroy
country: Australia
facility: St Vincent's Hospital Melbourne /ID# 205758
state: Victoria
city: Melbourne
country: Australia
facility: Monash Medical Centre /ID# 206486
state: Victoria
city: Murdoch
country: Australia
facility: Fiona Stanley Hospital /ID# 211642
state: Western Australia
city: Vienna
country: Austria
facility: Klinik Landstrasse /ID# 205764
state: Wien
city: Vienna
country: Austria
facility: Medical University of Vienna /ID# 205763
state: Wien
city: Salzburg
country: Austria
facility: LKH Salzburg and Paracelsus /ID# 208788
city: Leuven
country: Belgium
facility: Universitair Ziekenhuis Leuven /ID# 205988
state: Vlaams-Brabant
city: Gent
country: Belgium
facility: AZ Maria Middelares /ID# 210928
city: Banja Luka
country: Bosnia and Herzegovina
facility: University Clinical Centre of the Republic of Srpska /ID# 208053
state: Republika Srpska
city: Banja Luka
country: Bosnia and Herzegovina
facility: University Clinical Centre of the Republic of Srpska /ID# 208055
state: Republika Srpska
city: Tuzla
country: Bosnia and Herzegovina
facility: University Clinical Center Tuzla /ID# 208057
state: Tuzlanski
city: Mostar
country: Bosnia and Herzegovina
facility: University Clinical Hospital Mostar /ID# 208054
city: Sarajevo
country: Bosnia and Herzegovina
facility: Clinical Center University of Sarajevo /ID# 208058
city: Curitiba
country: Brazil
facility: Hospital Nossa Senhora das Graças /ID# 206981
state: Parana
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre /ID# 206985
state: Rio Grande Do Sul
city: Botucatu
country: Brazil
facility: Upeclin Fmb - Unesp /Id# 206986
state: Sao Paulo
city: Ribeirão Preto
country: Brazil
facility: Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 206504
state: Sao Paulo
city: Santo André
country: Brazil
facility: Faculdade de Medicina do ABC /ID# 206984
state: Sao Paulo
city: Sao Jose Do Rio Preto
country: Brazil
facility: Kaiser Clinica e Hospital Dia /ID# 206982
state: Sao Paulo
city: Calgary
country: Canada
facility: University of Calgary - Cumming School of Medicine - Adult Cystic Fibrosis Clini /ID# 205755
state: Alberta
city: Edmonton
country: Canada
facility: Allen Whey Khye Lim Professional Corporation /ID# 211167
state: Alberta
city: Edmonton
country: Canada
facility: Covenant Health /ID# 205500
state: Alberta
city: Victoria
country: Canada
facility: Percuro Clinical Research, Ltd /ID# 205501
state: British Columbia
city: Vaughan
country: Canada
facility: Duplicate_Toronto Digestive Disease Asso /ID# 205498
state: Ontario
city: Montreal
country: Canada
facility: Crchum /Id# 207387
state: Quebec
city: Sherbrooke
country: Canada
facility: CIUSSS de l'Estrie - CHUS /ID# 205499
state: Quebec
city: Santiago
country: Chile
facility: Research Group /ID# 208037
state: Region Metropolitana De Santiago
city: Santiago
country: Chile
facility: M y F Estudios Clínicos Ltda. /ID# 208035
state: Region Metropolitana De Santiago
city: Concepción
country: Chile
facility: Hospital Guillermo Grant Benavente de Concepción /ID# 212426
city: Providencia
country: Chile
facility: CTR Estudios Clinicos /ID# 208036
city: Santiago
country: Chile
facility: Hospital Clinico Universidad De Los Andes /ID# 207426
city: Guangzhou
country: China
facility: Sun Yat-sen Memorial Hospital of Sun Yat-sen University /ID# 205267
state: Guangdong
city: Guangzhou
country: China
facility: The Sixth Affiliated Hosp Sun /ID# 205268
state: Guangdong
city: Shiyan
country: China
facility: Affiliated Taihe Hospital of Hubei University of Medicine /ID# 216406
state: Hubei
city: Wuhan
country: China
facility: Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 205266
state: Hubei
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University /ID# 212186
state: Jiangxi
city: Changchun
country: China
facility: The First Hospital of Jilin University /ID# 210088
state: Jilin
city: Shanghai
country: China
facility: Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 205333
state: Shanghai
city: Hangzhou
country: China
facility: The second Affiliated hospital of Zhejiang University school of Medicine /ID# 205271
state: Zhejiang
city: Chengdu
country: China
facility: West China Hospital, Sichuan University /ID# 205332
city: Tianjin
country: China
facility: Duplicate_Tianjin Med Univ General Hosp /ID# 205246
city: Wuhan
country: China
facility: Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 205265
city: Monteria
country: Colombia
facility: Instituto Medico de Alta Tecnologia Oncomédica S.A /ID# 208887
state: Cordoba
city: Bogota DC
country: Colombia
facility: Corporacion Hospitalaria Juan Cuidad Sede Denominada Hospital Universitario Mayo /ID# 208886
state: Cundinamarca
city: Medellin
country: Colombia
facility: Hospital Universitario San Vic /ID# 208888
city: Zagreb
country: Croatia
facility: Klinicka bolnica Dubrava Zagreb /ID# 208460
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Poliklinika Solmed /ID# 211568
state: Grad Zagreb
city: Rijeka
country: Croatia
facility: Klinicki bolnicki centar Rijeka /ID# 208650
state: Primorsko-goranska Zupanija
city: Split
country: Croatia
facility: Klinicki bolnicki centar Split /ID# 217027
city: Hradec Kralove
country: Czechia
facility: Hepato-Gastroenterologie HK, s.r.o. /ID# 205672
city: Olomouc
country: Czechia
facility: CTCenter MaVe s.r.o. /ID# 205671
city: Ostrava
country: Czechia
facility: Artroscan s.r.o. /ID# 205668
city: Pardubice
country: Czechia
facility: Nemocnice Pardubickeho kraje, a.s. /ID# 213540
city: Praha
country: Czechia
facility: Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 216223
city: Praha
country: Czechia
facility: Axon Clinical, s.r.o. /ID# 205670
city: Praha
country: Czechia
facility: ISCARE a.s. /ID# 209240
city: Tallinn
country: Estonia
facility: East Tallinn Central Hospital /ID# 207564
state: Harjumaa
city: Tallinn
country: Estonia
facility: West Tallinn Central Hospital /ID# 207356
city: Tallinn
country: Estonia
facility: North Estonia Medical Centre /ID# 207357
city: Tartu
country: Estonia
facility: Tartu University Hospital /ID# 212282
city: Tampere
country: Finland
facility: Tampere University Hospital /ID# 206161
state: Pirkanmaa
city: Jyvaskyla
country: Finland
facility: Keski-Suomen Sairaala Nova /ID# 206159
city: Mikkeli
country: Finland
facility: Laakarikeskus Ikioma /ID# 205814
city: Turku
country: Finland
facility: Tyks /Id# 205813
city: Nice CEDEX 3
country: France
facility: Chu de Nice-Hopital L'Archet Ii /Id# 209118
state: Alpes-Maritimes
city: Pierre Benite CEDEX
country: France
facility: Centre Hospitalier Lyon Sud /ID# 209121
state: Rhone
city: Mannheim
country: Germany
facility: Universitatsklinikum Mannheim /ID# 206811
state: Baden-Wuerttemberg
city: Tübingen
country: Germany
facility: Duplicate_Universitaetsklinikum Tuebingen /ID# 206737
state: Baden-Wuerttemberg
city: Herne
country: Germany
facility: Gastroenterologische Gemeinschaftspraxis Herne /ID# 214576
state: Nordrhein-Westfalen
city: Saarbrücken
country: Germany
facility: Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 215813
state: Saarland
city: Berlin
country: Germany
facility: Duplicate_Praxis am Bayrischen Platz /ID# 206733
city: Frankfurt am Main
country: Germany
facility: Agaplesion Markus Krankenhaus /ID# 206731
city: Kiel
country: Germany
facility: Duplicate_Univ Hosp Schleswig-Holstein /ID# 206791
city: Muenster
country: Germany
facility: Medizinisches Versorgungszentrum Portal 10 /ID# 207137
city: Athens
country: Greece
facility: General Hospital of Athens Laiko /ID# 208671
state: Attiki
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 207061
state: Kriti
city: Athens
country: Greece
facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 206332
city: Thessaloniki
country: Greece
facility: Duplicate_General Hospital of Thessaloniki Hippokrateio /ID# 208822
city: Bekescsaba
country: Hungary
facility: Bekes Megyei Kozponti Korhaz /ID# 205885
city: Budapest
country: Hungary
facility: Semmelweis Egyetem /ID# 205883
city: Sopron
country: Hungary
facility: Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet /ID# 207992
city: Szekesfehervar
country: Hungary
facility: Mentahaz Maganorvosi Kozpont /ID# 205882
city: Dublin
country: Ireland
facility: Beaumont Hospital /ID# 206509
city: Galway
country: Ireland
facility: University Hospital Galway /ID# 218035
city: Haifa
country: Israel
facility: Rambam Health Care Campus /ID# 206362
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center /ID# 206365
city: Bologna
country: Italy
facility: A.O.U. Policlinico S.Orsola-Malpighi /ID# 206351
state: Emilia-Romagna
city: Rho
country: Italy
facility: ASST Rhodense/Presidio Ospedaliero di Rho /ID# 216611
state: Milano
city: Rozzano
country: Italy
facility: Istituto Clinico Humanitas /ID# 206346
state: Milano
city: Rome
country: Italy
facility: Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 206347
state: Roma
city: Negrar
country: Italy
facility: IRCCS Ospedale Sacro Cuore Don Calabria /ID# 206354
state: Verona
city: Milan
country: Italy
facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 206349
city: Palermo
country: Italy
facility: A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 206350
city: Nagoya shi
country: Japan
facility: Nagoya City University Hospital /ID# 206058
state: Aichi
city: Nagoyashi
country: Japan
facility: Nagoya University Hospital /ID# 206355
state: Aichi
city: Toyohashi-shi
country: Japan
facility: Toyohashi Municipal Hospital /ID# 207625
state: Aichi
city: Toyota-shi
country: Japan
facility: Ieda Hospital /ID# 207479
state: Aichi
city: Hirosaki-shi
country: Japan
facility: Hirosaki National Hospital /ID# 206387
state: Aomori
city: Abiko-shi
country: Japan
facility: Tokatsu Tsujinaka Hospital /ID# 214963
state: Chiba
city: Kashiwa-shi
country: Japan
facility: Tsujinaka Hospital Kashiwanoha /ID# 209573
state: Chiba
city: Sakura-shi
country: Japan
facility: Toho University Medical Center Sakura Hospital /ID# 207705
state: Chiba
city: Urayasu-shi
country: Japan
facility: Juntendo University Urayasu Hospital /ID# 208784
state: Chiba
city: Fukui-shi
country: Japan
facility: Fukui Prefectural Hospital /ID# 210449
state: Fukui
city: Chikushino-shi
country: Japan
facility: Fukuoka University Chikushi Hospital /ID# 214405
state: Fukuoka
city: Fukuoka-shi
country: Japan
facility: Saiseikai Fukuoka Genaral Hospital /ID# 209482
state: Fukuoka
city: Kurume-shi
country: Japan
facility: Kurume University Hospital /ID# 206385
state: Fukuoka
city: Ogaki-shi
country: Japan
facility: Ogaki Municipal Hospital /ID# 208227
state: Gifu
city: Fukuyama-shi
country: Japan
facility: NHO Fukuyama Medical Center /ID# 206295
state: Hiroshima
city: Hiroshima-shi
country: Japan
facility: Hiroshima University Hospital /ID# 206464
state: Hiroshima
city: Midorigaokahiga-shi
country: Japan
facility: Asahikawa Medical University Hospital /ID# 206404
state: Hokkaido
city: Obihiro-shi
country: Japan
facility: Obihiro kosei Hospital /ID# 210424
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo Tokushukai Hospital /ID# 209448
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 206059
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo Medical University Hospital /ID# 206314
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo Higashi Tokushukai Hospital /ID# 208494
state: Hokkaido
city: Kobe-shi
country: Japan
facility: Aoyama Clinic /ID# 206452
state: Hyogo
city: Nishinomiya-shi
country: Japan
facility: Hyogo College of Medicine Hospital /ID# 206455
state: Hyogo
city: Kanazawa-shi
country: Japan
facility: Kanazawa University Hospital /ID# 206316
state: Ishikawa
city: Morioka-shi
country: Japan
facility: Iwate Medical University Uchimaru Medical Center /ID# 207051
state: Iwate
city: Kagoshima-shi
country: Japan
facility: Idzuro Imamura Hospital /ID# 207639
state: Kagoshima
city: Kagoshima-shi
country: Japan
facility: Sameshima Hospital /ID# 207935
state: Kagoshima
city: Kawasaki-shi
country: Japan
facility: St. Marianna University School of Medicine Hospital /ID# 209451
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Showa University Fujigaoka Hospital /ID# 208224
state: Kanagawa
city: Kyoto-shi
country: Japan
facility: Kyoto University Hospital /ID# 211809
state: Kyoto
city: Tsu-shi
country: Japan
facility: Mie University Hospital /ID# 206803
state: Mie
city: Yokkaichi-shi
country: Japan
facility: Yokkaichi Hazu Medical Center /ID# 214348
state: Mie
city: Sendai-shi
country: Japan
facility: National Hospital Organization Sendai Medical Center /ID# 209528
state: Miyagi
city: Omura-shi
country: Japan
facility: NHO Nagasaki Medical Center /ID# 210822
state: Nagasaki
city: Yamatotakada-shi
country: Japan
facility: Kenseikai Dongo Hospital /ID# 208101
state: Nara
city: Niigata-shi
country: Japan
facility: Saiseikai Niigata Hospital /ID# 209921
state: Niigata
city: Niigata-shi
country: Japan
facility: Niigata University Medical & Dental Hospital /ID# 218049
state: Niigata
city: Oita-shi
country: Japan
facility: Ishida Clinic of IBD and Gastroenterology /ID# 210119
state: Oita
city: Kurashiki-shi
country: Japan
facility: Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 206646
state: Okayama
city: Okayama-shi
country: Japan
facility: Okayama University Hospital /ID# 217925
state: Okayama
city: Osaka-shi
country: Japan
facility: Kinshukai Infusion Clinic /ID# 207865
state: Osaka
city: Osaka-shi
country: Japan
facility: Kitano Hospital /ID# 210397
state: Osaka
city: Osaka-shi
country: Japan
facility: Japanese Red Cross Osaka Hospital /ID# 209478
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka City University Hospital /ID# 206457
state: Osaka
city: Toyonaka-shi
country: Japan
facility: Toyonaka Municipal Hospital /ID# 217082
state: Osaka
city: Saga-shi
country: Japan
facility: Saga University Hospital /ID# 209270
state: Saga
city: Kawagoe-shi
country: Japan
facility: Saitama Medical Center /ID# 206393
state: Saitama
city: Saitama-shi
country: Japan
facility: Tokitokai Tokito clinic /ID# 206313
state: Saitama
city: Higashi-ohmi-shi
country: Japan
facility: National Hospital Organization Higashi-Ohmi General Medical Center /ID# 210710
state: Shiga
city: Izumo-shi
country: Japan
facility: Shimane University School of Medicine /ID# 208905
state: Shimane
city: Hamamatsu-shi
country: Japan
facility: Hamamatsu University Hospital /ID# 206459
state: Shizuoka
city: Sunto-gun
country: Japan
facility: NHO Shizuoka Medical Center /ID# 208785
state: Shizuoka
city: Bunkyo-ku
country: Japan
facility: Tokyo Medical And Dental University, Medical Hospital /ID# 206453
state: Tokyo
city: Chuo-ku
country: Japan
facility: St.Luke's International Hospital /ID# 208076
state: Tokyo
city: Hachioji-shi
country: Japan
facility: Tokai University Hachioji Hospital /ID# 208903
state: Tokyo
city: Itabashi-ku
country: Japan
facility: Teikyo University Hospital /ID# 209866
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Center Hospital of the National Center for Global Health and Medicine /ID# 209532
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Tokyo Women's Medical University Hospital /ID# 206460
state: Tokyo
city: Yamagata-shi
country: Japan
facility: Yamagata University Hospital /ID# 206465
state: Yamagata
city: Shunan-shi
country: Japan
facility: Tokuyama Central Hospital /ID# 216994
state: Yamaguchi
city: Takatsuki-shi
country: Japan
facility: Shoyukai Fujita Gastroenterological Hospital /ID# 216493
city: Seoul
country: Korea, Republic of
facility: Kangbuk Samsung Hospital /ID# 206960
state: Seoul Teugbyeolsi
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital /ID# 206955
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital /ID# 206956
city: Daegu
country: Korea, Republic of
facility: Yeungnam University Medical Center /ID# 206959
city: Seongnam-si, Gyeonggi-do
country: Korea, Republic of
facility: Duplicate_CHA Bundang Medical Center /ID# 207432
city: Seoul
country: Korea, Republic of
facility: Yonsei University Health System, Severance hospital /ID# 206958
city: Riga
country: Latvia
facility: Riga East Clinical Univ Hosp /ID# 206828
city: Riga
country: Latvia
facility: P. Stradins Clinical Univ Hosp /ID# 206827
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 209052
city: Klaipeda
country: Lithuania
facility: Klaipeda Seamens Hospital /ID# 208791
city: Klaipeda
country: Lithuania
facility: Klaipeda University Hospital /ID# 208790
city: Vilnius
country: Lithuania
facility: Vilnius University Hospital /ID# 209051
city: Kuala Lumpur
country: Malaysia
facility: Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 207662
state: Selangor
city: Kuala Lumpur
country: Malaysia
facility: Duplicate_Uni Malaya MC /ID# 208936
city: Leon
country: Mexico
facility: Morales Vargas Centro de Investigacion S.C. /ID# 211326
state: Guanajuato
city: Guadalajara
country: Mexico
facility: Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 208068
state: Jalisco
city: Monterrey
country: Mexico
facility: Centro Regiomontano de Estudios Clínicos ROMA S.C /ID# 208067
state: Nuevo Leon
city: Rotterdam
country: Netherlands
facility: Erasmus Medisch Centrum /ID# 205280
city: Lorenskog
country: Norway
facility: Akershus Universitetssykehus_MAIN /ID# 205293
state: Akershus
city: Tromsø
country: Norway
facility: Universitetssykehuset Nord-Norge /ID# 205691
state: Troms
city: Torun
country: Poland
facility: Gastromed /Id# 216108
state: Kujawsko-pomorskie
city: Warsaw
country: Poland
facility: Centrum Medyczne Reuma Park w Warszawie /ID# 212913
state: Mazowieckie
city: Warszawa
country: Poland
facility: Centrum Zdrowia MDM /ID# 205874
state: Mazowieckie
city: Warszawa
country: Poland
facility: NZOZ Vivamed /ID# 216697
state: Mazowieckie
city: Warszawa
country: Poland
facility: Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 215070
state: Mazowieckie
city: Sopot
country: Poland
facility: Endoskopia Sp. z o.o. /ID# 212964
state: Pomorskie
city: Guimaraes
country: Portugal
facility: Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 205554
state: Braga
city: Santa Maria Da Feira
country: Portugal
facility: Centro Hospitalar de Entre Douro e Vouga /ID# 205563
state: Porto
city: Ponte de Lima
country: Portugal
facility: Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 205556
state: Viana Do Castelo
city: Almada
country: Portugal
facility: Hospital Garcia de Orta, EPE /ID# 206143
city: Braga
country: Portugal
facility: CCA Braga - Hospital de Braga /ID# 206144
city: Lisboa
country: Portugal
facility: Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 206117
city: Lisbon
country: Portugal
facility: Hospital Santo Antonio dos Cap /ID# 206145
city: Porto
country: Portugal
facility: Centro Hospitalar Universitario de Sao Joao, EPE /ID# 206142
city: San Juan
country: Puerto Rico
facility: School of Medicine University of Puerto Rico-Medical Science Campus /ID# 209626
city: Kaliningrad
country: Russian Federation
facility: Immanuel Kant Baltic Federal University /ID# 208264
state: Kaliningradskaya Oblast
city: St. Petersburg
country: Russian Federation
facility: NW State Medical Univ na Mechn /ID# 208258
state: Leningradskaya Oblast
city: Perm
country: Russian Federation
facility: Perm Clinical Center of the Federal Medical and Biological Agency /ID# 211653
state: Permskiy Kray
city: Samara
country: Russian Federation
facility: Medical Company Hepatolog /ID# 208261
state: Samarskaya Oblast
city: Stavropol
country: Russian Federation
facility: Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 211652
state: Stavropol Skiy Kray
city: Kazan
country: Russian Federation
facility: Kazan State Medical University /ID# 208256
state: Tatarstan, Respublika
city: Moscow
country: Russian Federation
facility: Olla-Med Clinic /ID# 215335
city: Petrozavodsk
country: Russian Federation
facility: Republican hospital named after V.A. Baranov /ID# 206507
city: Pushkin
country: Russian Federation
facility: Euromedservice /ID# 208265
city: Pyatigorsk
country: Russian Federation
facility: LLC Novaya Clinica /ID# 208260
city: Belgrade
country: Serbia
facility: Clinical Hosp Center Zvezdara /ID# 205258
state: Beograd
city: Belgrade
country: Serbia
facility: Military Medical Academy /ID# 205257
state: Beograd
city: Belgrade
country: Serbia
facility: University Clinical Center Serbia /ID# 205256
state: Beograd
city: Belgrade
country: Serbia
facility: Clin Hosp Ctr Bezanijska Kosa /ID# 206413
state: Beograd
city: NIS
country: Serbia
facility: University Clinical Center of Nis /ID# 206411
state: Nisavski Okrug
city: Kragujevac
country: Serbia
facility: University Clinical Center Kragujevac /ID# 206410
state: Sumadijski Okrug
city: Novi Sad
country: Serbia
facility: Clinical Center Vojvodina /ID# 205259
state: Vojvodina
city: Leskovac
country: Serbia
facility: General Hospital Leskovac /ID# 217881
city: Singapore
country: Singapore
facility: National University Hospital /ID# 209099
city: Singapore
country: Singapore
facility: Gleneagles Medical Centre /ID# 206954
city: Singapore
country: Singapore
facility: Tan Tock Seng Hospital /ID# 207663
city: Bratislava
country: Slovakia
facility: Medak s.r.o. /ID# 205191
state: Bratislavsky Kraj
city: Banska Bystrica
country: Slovakia
facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 205147
city: Kosice
country: Slovakia
facility: B+B MED, s.r.o. /ID# 205213
city: Nove Zamky
country: Slovakia
facility: Fakultna nemocnica s poliklini /ID# 211372
city: Presov
country: Slovakia
facility: GASTRO I., s.r.o. /ID# 205148
city: Boksburg North
country: South Africa
facility: MD Search /ID# 208084
state: Gauteng
city: Johannesburg
country: South Africa
facility: Clinresco Centers /ID# 208083
state: Gauteng
city: Johannesburg
country: South Africa
facility: Lenasia Clinical Trial Centre /ID# 214359
state: Gauteng
city: Johannesburg
country: South Africa
facility: Wits Clinical Research , Wits Health Consortium (PTY) Ltd /ID# 208082
state: Gauteng
city: Johannesburg
country: South Africa
facility: Wits Clinical Research Site /ID# 208949
state: Gauteng
city: CAPE TOWN Milnerton
country: South Africa
facility: Mediclinic Milnerton /ID# 207979
state: Western Cape
city: Cape Town
country: South Africa
facility: Kingsbury Hospital /ID# 205281
state: Western Cape
city: Cape Town
country: South Africa
facility: Private Practice Dr MN Rajabally /ID# 205273
state: Western Cape
city: Santiago de Compostela
country: Spain
facility: Hospital Clínico Universitario de Santiago-CHUS /ID# 204411
state: A Coruna
city: Santander
country: Spain
facility: Hospital Unversitario Marques de Valdecilla /ID# 216622
state: Cantabria
city: Las Palmas de Gran Canaria
country: Spain
facility: Hospital Universitario Dr. Negrin /ID# 206905
state: Las Palmas
city: A Coruna
country: Spain
facility: Hospital Universitario A Coruna - CHUAC /ID# 206907
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona /ID# 206906
city: Cordoba
country: Spain
facility: Hospital Universitario Reina Sofia /ID# 204412
city: Madrid
country: Spain
facility: Hospital Universitario Ramon y Cajal /ID# 204410
city: Madrid
country: Spain
facility: Hospital Universitario La Paz /ID# 214540
city: Salamanca
country: Spain
facility: Hospital Clinico Universitario de Salamanca /ID# 205013
city: Valencia
country: Spain
facility: Hospital Universitario y Politecnico La Fe /ID# 206904
city: St. Gallen
country: Switzerland
facility: Kantonsspital St. Gallen /ID# 211310
state: Sankt Gallen
city: Basel
country: Switzerland
facility: Universitaetsspital Basel /ID# 211381
city: Bern
country: Switzerland
facility: Inselspital, Universitaetsklinik /ID# 211312
city: Zurich
country: Switzerland
facility: Universitaetsspital Zuerich /ID# 211308
city: Taichung City
country: Taiwan
facility: China Medical University Hosp /ID# 207845
state: Taichung
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital /ID# 207847
state: Taipei
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 207848
city: Taipei City
country: Taiwan
facility: Taipei Veterans General Hosp /ID# 207849
city: Melikgazi
country: Turkey
facility: Erciyes University Medical Fac /ID# 207506
state: Kayseri
city: Ankara GAZI
country: Turkey
facility: Gazi University Med. Faculty /ID# 208040
city: Istanbul
country: Turkey
facility: Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 207507
city: Istanbul
country: Turkey
facility: Umraniye Training and Res Hosp /ID# 208206
city: Mersin
country: Turkey
facility: Mersin University Medical /ID# 208039
city: Kharkiv
country: Ukraine
facility: Communal Non-Commercial Enterprize of Kharkiv Regional Council Regional Clinical /ID# 206939
state: Kharkivska Oblast
city: Kyiv
country: Ukraine
facility: Kyiv Regional Hospital /ID# 217373
state: Kyivska Oblast
city: Kropyvnytskyi
country: Ukraine
facility: PE PMC Acinus, Medical and Diagnostic Center /ID# 217218
city: Kyiv
country: Ukraine
facility: Medical centre of CONSILIUM MEDICAL LLC /ID# 217447
city: Vinnytsia
country: Ukraine
facility: Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 216300
city: Basingstoke
country: United Kingdom
facility: Basingstoke & North Hampshire /ID# 207985
city: Glasgow
country: United Kingdom
facility: Queen Elizabeth University Hos /ID# 205154
city: Huddersfield
country: United Kingdom
facility: Huddersfield Royal Infirmary /ID# 217660
city: London
country: United Kingdom
facility: St. George's Healthcare NHS /ID# 208375
city: Whitechapel
country: United Kingdom
facility: Barts and the London NHS Trust /ID# 205153
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References:
citation: Danese S, Vermeire S, Zhou W, Pangan AL, Siffledeen J, Greenbloom S, Hebuterne X, D'Haens G, Nakase H, Panes J, Higgins PDR, Juillerat P, Lindsay JO, Loftus EV Jr, Sandborn WJ, Reinisch W, Chen MH, Sanchez Gonzalez Y, Huang B, Xie W, Liu J, Weinreich MA, Panaccione R. Upadacitinib as induction and maintenance therapy for moderately to severely active ulcerative colitis: results from three phase 3, multicentre, double-blind, randomised trials. Lancet. 2022 Jun 4;399(10341):2113-2128. doi: 10.1016/S0140-6736(22)00581-5. Epub 2022 May 26.