louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06926257: Effects of VR-based Respiratory Training on Motor Reaction Time and Correctness, Stress Levels, Attention, Motor Skills, Postural Stability and Sleep Quality in Shift Healthcare Workers
Official title: Effects of VR-based Respiratory Training on Motor Reaction Time and Correctness, Stress Levels, Attention, Motor Skills, Postural Stability and Sleep Quality in Shift Healthcare Workers
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Healthcare Workers
Stress Level
Emergency Department
Shift Work Sleep Disorder
Postural Stability
VR Breathing Exercises
Attention
Time Reaction
Lead sponsor: Poznan University of Physical Education
Sponsor class: OTHER
First posted: 2025-04-13
Enrollment: 60
Sex: ALL
Minimum age (years): 23
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study investigates the effects of virtual reality (VR)-based respiratory training on various physiological and cognitive functions in shift-working healthcare professionals, including paramedics and nurses. The research will evaluate how VR-guided breathing exercises influence: stress levels, motor reaction time and accuracy, attention and cognitive performance, motor skills and postural stability, sleep quality

Participants will be divided into three groups:

VR-based respiratory training group - performing guided breathing exercises in a VR environment.

Music-based relaxation group - listening to relaxing music without structured breathing instructions.

Control group - no intervention.

The findings will help determine whether VR-based respiratory training is an effective method for improving stress resilience, cognitive function, and physical performance in shift-working healthcare professionals.


Eligibility criteria: The study will be conducted in a group of paramedics and nurses of both sexes, aged 23-45. It is expected that 60 people will be examined. The study will include hospital emergency department employees, working shifts, with a minimum of two years of work experience. Those who receive a doctor's consent to participate in the study and give informed consent will be admitted to the study.

Primary outcomes:
measure: Attention and reaction time
timeFrame: At the beginning of the study and after 4 weeks of breathing exercises.
measure: Postural stability
timeFrame: At the beginning of the study and after 4 weeks of breathing exercises.
measure: Sleep quality
timeFrame: At the beginning of the study and after 4 weeks of breathing exercises.
measure: Stress level and mood
timeFrame: At the beginning of the study and after 4 weeks of breathing exercises.
measure: Fine motor skills precision
timeFrame: At the beginning of the study and after 4 weeks of breathing exercises.
Secondary outcomes:
Other outcomes:
Locations:
city: Poznań
country: Poland
facility: Poznań University of Physical Education
Study officials:
References:
Clinical trial NCT01775657: Digital Versus Analog Pleural Drainage Following Pulmonary Resection
Official title: Digital Versus Analog Pleural Drainage Following Pulmonary Resection
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pulmonary Air Leak
Lobectomy
Wedge Resection
Segmentectomy
Keywords: pulmonary air leak
Thopaz
digital
analog
randomized
Lead sponsor: Ottawa Hospital Research Institute
Sponsor class: OTHER
First posted: 2013-01-25
Enrollment: 176
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study will evaluate the impact of continuous, digital pulmonary air leak monitoring on the duration of pleural drainage after lung resection in patients with and without a pulmonary air leak on postoperative day 1.

Patients undergoing pulmonary resection who fit the inclusion criteria will be identified pre-operatively. Patients within two groups (air leak and no air leak) will be randomized to receive either the analogue system or the digital system. Both systems are approved for use in hospitals by Health Canada. There will be 88 patients in each air leak group.

Hypothesis: Continuous, quantitative monitoring of PAL following lung resection leads to an improvement in primary outcomes.


Eligibility criteria: Inclusion Criteria:

Elective pulmonary resection (i.e. wedge, segmentectomy, lobectomy, bilobectomy) for benign or neoplastic disease

Exclusion Criteria:

1. Development of tension pneumothorax
2. Pneumonectomy
3. Patient no longer within planned randomization window
4. Plan to remove or removal of all chest drains within 36 hours of surgery
5. Inability to provide informed consent
6. Age \< 18 years
7. Patient was previously randomized following pulmonary resection

Primary outcomes:
measure: Overall length of hospitalization
timeFrame: Up to 5 days post-op (average)
Secondary outcomes:
measure: Time to first pleural drain removal
timeFrame: Over 24 hours post-op
Other outcomes:
Locations:
city: Ottawa
country: Canada
facility: Ottawa Hospital, General Campus
state: Ontario
Study officials:
affiliation: Ottawa Hospital Research Institute
name: Sebastien Gilbert, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gilbert S, McGuire AL, Maghera S, Sundaresan SR, Seely AJ, Maziak DE, Shamji FM, Villeneuve PJ. Randomized trial of digital versus analog pleural drainage in patients with or without a pulmonary air leak after lung resection. J Thorac Cardiovasc Surg. 2015 Nov;150(5):1243-9. doi: 10.1016/j.jtcvs.2015.08.051. Epub 2015 Aug 28.
Clinical trial NCT02744157: Long Term Effects of a Structured Lifestyle Program
Official title: Long Term Effects on Lifestyle Habits and Quality of Life in Individuals With Increased Cardiometabolic Risk Participating in a Structured Lifestyle Intervention Program
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lifestyle
Quality of Life
Lead sponsor: Karolinska University Hospital
Sponsor class: OTHER
Collaborators: name: Region Stockholm
First posted: 2016-04-20
Enrollment: 102
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The aim of the present study was to describe a structured intervention to reduce cardiovascular risk in a clinical setting and to study the effects of the program on lifestyle habits and quality of life in individuals at risk after six months and one year.


Eligibility criteria: Inclusion criteria:

(three risk factors )

* cardiovascular disease
* physical inactivity
* smoking
* risk consumption of alcohol
* unhealthy food habits
* stress
* overweight or abdominal obesity
* high lipids (cholesterol, LDL)
* high blood pressure
* diabetes/insulin resistance.

Exclusion criteria:

* Not understand Swedish language

Primary outcomes:
measure: Cardiovascular risk
timeFrame: change from baseline in waist circumference after one year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Karolinska Institutet, Department of medicine and Karolinska University Hospital,Department of Cardiology
name: Mai-Lis Hellenius, Professor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lidin M, Hellenius ML, Rydell-Karlsson M, Ekblom-Bak E. Long-term effects on cardiovascular risk of a structured multidisciplinary lifestyle program in clinical practice. BMC Cardiovasc Disord. 2018 Apr 2;18(1):59. doi: 10.1186/s12872-018-0792-6.
Clinical trial NCT02460757: Glottic Width and Respiratory Flow in Patients With Various Lung Diseases
Official title: Glottic Width and Respiratory Flow in Patients With Various Lung Diseases
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lung Diseases
Keywords: glottic movement
emphysema
copd
vocal cord
Lead sponsor: University Hospital, Essen
Sponsor class: OTHER
First posted: 2015-06-02
Enrollment: 56
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with various lung diseases in a primary care clinic

Brief summary: In this study the investigators examine the glottic width and the respiratory flow at rest in patients with various lung disease. The investigators postulated that a positive expiratory pressure is created through the narrowing of the glottic width in patients with hyperinflation.


Eligibility criteria: Inclusion Criteria:

* Clinical indication for a bronchoscopy
* Minimum age of 18 years
* Signed informed consent

Exclusion Criteria:

* Patients requiring mechanical ventilation during bronchoscopy
* Disease of the larynx
* Inability to breathe through the mouthpiece

Primary outcomes:
measure: Angle of the glottic width
timeFrame: 18 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Essen
country: Germany
facility: Ruhrlandklinik
Study officials:
References:
Clinical trial NCT04133857: Acute Effects of HIIT and SSMIT on Intraocular Pressure Among Sedentary Individuals
Official title: Acute Effects of High Intensity Interval Training (HIIT) and Steady State Moderate Intensity Training (SSMIT) on Intraocular Pressure Among Sedentary Individuals
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Intraocular Pressure
Lead sponsor: University of Malaya
Sponsor class: OTHER
First posted: 2019-10-21
Enrollment: 40
Sex: ALL
Minimum age (years): 21
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Purpose to study the acute effects of both forms of aerobic exercise (HIIT and SSMIT) on intraocular pressure among healthy sedentary individuals

Detailed description: 40 participants were recruited and divided into 2 groups. Each group performed 2 exercise protocols with a 4 day washout period between them.

The intraocular pressure was measured before the exercise and after the exercise in 5 minute periods up until 30 minutes post exercise.

The intraocular pressure was measured using a handheld rebound tonometer.

Eligibility criteria: Inclusion Criteria:

* all University hospital staff

Exclusion Criteria:

* previous ocular trauma
* surgery in the eligible eye
* known case of glaucoma or glaucoma suspect (IOP \> 21mmHg)
* history of glaucoma laser procedure/surgery within 6 months in eligible eye
* unable to undergo IOP measurements
* undiagnosed visual condition
* any uncontrolled medical condition such as end stage renal failure, uncontrolled diabetes and uncontrolled hypertension

Primary outcomes:
measure: Changes in intraocular pressure
timeFrame: 30 minutes
Secondary outcomes:
measure: compare which form of exercise (HIIT & SSMIT) is superior in reducing intraocular pressure
timeFrame: 30 days
Other outcomes:
Locations:
city: Kuala Lumpur
country: Malaysia
facility: University Malaya
state: Wilayah Perseketuan
Study officials:
References:
Clinical trial NCT05875857: Patient Utilization of Opioid Destruction Bags in the Post-op Period
Official title: Patient Utilization of Opioid Destruction Bags in the Post-op Period
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Opioid Use
Opioid Use, Unspecified
Patient Empowerment
Total Knee Arthoplasty
Total Hip Arthroplasty
Lead sponsor: University of Nebraska
Sponsor class: OTHER
First posted: 2023-05-25
Enrollment: 163
Sex: ALL
Minimum age (years): 19
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: This is a study on how patients use and store opioid pain medications at home after surgery and what happens to left over pills when patients are done taking them. Participants will be taught the proper storage and destruction of opioid pain medications, then contacted in 6-8 weeks about pain medication used, stored disposed of.

Detailed description: This is a randomized single-center prospective survey study to describe the utilization of opioid destruction bags in the post-operative period. Participants who underwent surgery for Total Knee Arthroplasty (TKA) or Total Hip Arthroplasty (THA) will be eligible for inclusion if discharging to home with an opioid prescription. Eligible participants will be randomized between two groups: 1) Control group will receive current standard of care 2) Intervention group will receive a specialized handout and patient education on the safe storage of opioid medications, importance of opioid destruction, opioid destruction options and medication destruction (Deterra) bag before discharge. Participants will be phoned/emailed six to eight weeks post-surgery to complete a survey. Attempts will be made on three separate days to reach the participant via phone. If email is preferred, three reminders will be sent to complete the survey. If participant is unreachable, they will be considered lost to follow up. Survey questions will be comprised of various question styles, including: yes/no, multiple choice, and free text answers.

Eligibility criteria: Inclusion Criteria:

19 years of age or older Discharging to home and prescribed opioids at discharge post total knee arthroplasty or total hip arthroplasty

Exclusion Criteria:

Under 19 years of age Opioid medication use prior to surgery Not prescribed an opioid to take after discharge

Primary outcomes:
measure: Opioid destruction
timeFrame: Six to Eight weeks post discharge
Secondary outcomes:
measure: Alternative opioid destruction methods
timeFrame: Six to Eight weeks post discharge
Other outcomes:
Locations:
city: Omaha
country: United States
facility: University of Nebraska Medical Center
state: Nebraska
Study officials:
affiliation: University of Nebraska
name: Kristin R Daniel, PharmD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06880965: Effect of Concentrated Growth Factors on Short Implant-Supported Overdentures
Official title: Effect of Concentrated Growth Factors on Short Implant-Supported Overdentures: a Split-Mouth Design Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Partially Edentulous Patients
Keywords: CGF, Overdenture
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2025-03-18
Enrollment: 10
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this study will be to evaluate the effect of concentrated growth factors on stability and radiographic outcome of short implant supported mandibular assisted overdenture

Detailed description: A controlled clinical trial will be performed upon patients attending the outpatient clinic of Faculty of Dentistry Tanta University.Ten male patients will be selected for this study. Split mouth study design will be used in this study where, Group I represented the right side of the patients' mandibular posterior region will be restored with short implant in place of first molar and Group II represented the left side of the patients' mandibular posterior region will be restored with short implant in place of first molar and concentrated growth factors. The patients will receive partial mandibular assisted overdenture with O-ring attachment on the implant. Stability of implant and Radiographic evaluations will be carried out for every patient at regular recall visits at the time of insertion, 6 and 12 months

Eligibility criteria: Inclusion Criteria:

* Patients between 20 to 65 years old. Class I Kennedy's classification Good oral hygiene.

Exclusion Criteria:

* Bad oral hygiene. Para functional habits ex. (bruxism, clenching,)

Primary outcomes:
measure: Concentrated growth factor (CGF) Effects
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Tanta university
state: Gharbiya
Study officials:
affiliation: Tanta University
name: Sherin F Donia, PHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01766466: Cangrelor Ticagrelor Transition Study
Official title: A Study of the Transition From Cangrelor to Ticagrelor, and Ticagrelor to Cangrelor in Patients With Coronary Artery Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Coronary Artery Disease
Lead sponsor: The Medicines Company
Sponsor class: INDUSTRY
First posted: 2013-01-11
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL

Brief summary: To demonstrate that patients treated with cangrelor can be directly switched to oral ticagrelor and that patients treated with ticagrelor can be switched to cangrelor without a significant decrease in the extent of inhibition of platelet aggregation.


Eligibility criteria: Inclusion Criteria:

* greater than / equal to 18 and less than 75 years of age

  1. Previous myocardial infarction defined by admission to the hospital with elevation of markers of injury or the presence of pathologic q waves on at least 2 contiguous electrocardiogram (ECG) leads.

     OR
  2. Previous revascularization by percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery.

     AND
  3. Treatment with aspirin (ASA) 81 mg daily.

     Exclusion Criteria:

Primary outcomes:
measure: Extent of Preservation of Inhibitory Effect Compared With Effect Observed With Cangrelor Alone (at Timepoint 1, Either at 0.5 Hours or 1.25 Hours) or Ticagrelor Alone (Measured 5.25 Hours After Initiation of Cangrelor on Day 1)
timeFrame: Day 1 measures taken at 2 timepoints after cangrelor infusion start: 0.5 or 1.5 hrs (Timepoint 1) and 5.25 hrs (TImepoint 2)
measure: Extent of Preservation of Inhibitory Effect Compared With Effect Observed During Cangrelor Treatment After Ticagrelor
timeFrame: Day 5 at 1.0 and 2.0 hours after the initiation of cangrelor infusion
measure: Extent of Aggregation Response During Ticagrelor Treatment
timeFrame: Day 1 at 2.25, 2.5, 2.75, 3 and 4 hrs following initiation of cangrelor infusion
Secondary outcomes:
Other outcomes:
Locations:
city: Burlington
country: United States
facility: Fletcher Allen Health Care
state: Vermont
Study officials:
affiliation: University of Vermont Medical Center
name: David J. Schneider, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01533766: A Safety, Efficacy Study of CombiflexOmega Versus SmofKabiven in Patients With Parenteral Nutrition
Official title: A Randomized, Open, Multicenter, Compared Phase III Trial to Evaluate the Safety, Efficacy of CombiflexOmega and SmofKabiven in Postoperative Patients Requiring Parenteral Nutrition
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Parent
Lead sponsor: JW Pharmaceutical
Sponsor class: INDUSTRY
First posted: 2012-02-15
Enrollment: 50
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the safety and efficacy of CombiflexOmega in comparison to SmofKabiven in postoperative patients requiring parenteral nutrition.


Eligibility criteria: Inclusion Criteria:

* Patients aged 20 and older
* Patients are expected to require PN for more than 5 days
* Patients who voluntarily signed the consent form

Exclusion Criteria:

* Patients are expected difficult to survive more than 5 days
* Pregnant or breast-feeding women
* BMI \> 30 kg/m2
* Patients with severe blood coagulation disorders
* Patients with congenital amino acid metabolism disorders
* Patients with acute shock
* Patients with uncontrollable diabetes mellitus
* Patients with hemophage syndrome
* Patients with hypopotassemia (K \< 3.0mEq/L)
* Patients having the history of myocardial infarction
* Patients reported the following laboratory value

  * fasting TG \> 250mg/dl, TC \> 300mg/dl
  * ALT/AST ≥ 2×ULN, Bilirubin ≥ 3mg/dl (Exception : patients with periampullary carcinoma including biliary tract or pancreas)
  * Creatinine ≥ 1.5mg/dl
  * Ca \> 11.2mg/dl, Na ≥ 145mEq/L, Mg ≥ 2.1mEq/L, K ≥ 5.5mEq/L
* Patients having hypersensitivity to any peanut-, fish-, soy-, egg protein, or investigational drug
* Patients having the history of drug or alcohol abuse
* General contraindications to infusion therapy: acute pulmonary oedema, hyperhydration, cardiac decompensation
* Patients are in unstable conditions
* Patients with difficult peripheral intravenous
* Patients with parenteral nutrition within 7 days prior to start of the trial
* Participation in another clinical study with an investigational drug or an investigational medical device within 28 days prior to start of study
* Patients judged to be unsuitable for this trial by investigators

Primary outcomes:
measure: Comparison of adverse drug reaction
timeFrame: 6days
Secondary outcomes:
measure: Changes of laboratory parameters (biochemistry, hematology, coagulation)
timeFrame: 7days
measure: Changes of vital signs
timeFrame: 7days
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
Study officials:
References: