louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02749266: The Impact of Chiropractic Activator Adjustments on Mental Rotation and Line Judgment Reaction Time
Official title: The Impact of Chiropractic Activator Adjustments on Mental Rotation and Line Judgment Reaction Time: A Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cognition - Other
Keywords: chiropractic, cognition
Lead sponsor: Life University
Sponsor class: OTHER
Collaborators: name: University of Georgia
First posted: 2016-04-22
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this pilot study will be to assess the impact of chiropractic Activator adjustments on spatial cognitive abilities through initial assessment and testing in a healthy population aged 18 to 35.

Detailed description: This study seeks to assess the impact of chiropractic on cognition. Participants must be between 18 and 35 years of age. Within the past six months individuals may not participate if they have had any broken bones, accidents, or surgeries to their spine. Additionally, participants cannot have any mental disabilities, be pregnant, or have other conditions of the spine such as bone mineral loss.

Patients will receive a chiropractic exam and will be randomized to a sham (simulated chiropractic adjustment) or chiropractic adjustment intervention group. Prior to receiving either the sham or chiropractic adjustment, the participants will sit in front of a computer screen and will be asked to follow instructions and press a button on a keypad. There will be three different types of computer assessments that will take approximately fifteen minutes total. After the computer assessments the participant will receive either the sham or chiropractic adjustment. The chiropractic adjustment and the sham will both utilize a handheld instrument called an Activator. After the adjustment or sham the participant will take the computer assessments again. The total time this may take is ninety minutes.

Eligibility criteria: Inclusion Criteria:

* Age 18 to 35
* In good health

Exclusion Criteria:

* pregnant
* medically diagnosed cognitive deficits
* medically diagnosed learning disabilities
* fractures, traumas, or surgeries to the spine within the past six months
* diagnosed osteoporosis, articular instability

Primary outcomes:
measure: Reaction time
timeFrame: Pre and Post intervention (average of 90 minutes)
Secondary outcomes:
measure: Response correctness
timeFrame: Pre and post intervention (average of 90 minutes)
Other outcomes:
Locations:
city: Marietta
country: United States
facility: Life University
state: Georgia
Study officials:
affiliation: Life University
name: Stephanie Sullivan, D.C.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03079466: Effect of CPAP Treatment on the Elderly With Mild to Moderate Sleep Apnea
Official title: Effect of CPAP Treatment on the Elderly With Mild to Moderate Sleep Apnea
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Unrecognized Condition
Keywords: Sleep apnea
Elderly
CPAP
Lead sponsor: Hospital Universitario Doctor Peset
Sponsor class: OTHER
First posted: 2017-03-14
Enrollment: 96
Sex: ALL
Minimum age (years): 70
Maximum age (years): 100
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized clinical trial
Primary purpose: TREATMENT

Brief summary: Objective: To analyze the impact of CPAP treatment on cognitive, clinical and quality of life domains in patients over 70 years of age with mild-to-moderate OSA

Primary Outcome: Epworth scale and QSQ domains

Secondary Outcomes: Neurocognitive variables and CPAP adherence


Eligibility criteria: Inclusion Criteria:

* Age equal or greater than 70 years of both sexes
* Patients with sleep study results with AHI ≥ 15 and \< 30

Exclusion Criteria:

* Alternative diagnoses of other non-respiratory sleep disorders that are also cause of pathological somnolence (eg, sdr restless legs, narcolepsy, etc.)
* Don't sign informed consent
* Acute or chronic respiratory insufficiency requiring home oxygen therapy
* Patients with Obesity Hypoventilation Syndrome
* Diagnosis of neuro-psychiatric diseases with the exception of anxiety - depression or diagnosis of dementia.
* Diseases of any origin in the acute phase
* Heart failure or recent stroke (less than 3 months).
* Central SAHS (more than 50% of the registry with central apneas or Cheyne-Stokes breathing)
* Pre-treatment with CPAP
* Inability to perform the diagnostic study of sleep due to the patient's condition
* Hipersomniaincapacitante (Epworth≥18) with no known or most likely cause related to SAHS

Primary outcomes:
measure: Epworth Sleepiness Scale
timeFrame: 3 months
measure: Quebec Sleep Questionnaire domains
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Martinez-Garcia MA, Oscullo G, Ponce S, Pastor E, Orosa B, Catalan P, Martinez A, Hernandez L, Muriel A, Chiner E, Vigil L, Carmona C, Mayos M, Garcia-Ortega A, Gomez-Olivas JD, Beauperthuy T, Bekki A, Gozal D. Effect of continuous positive airway pressure in very elderly with moderate-to-severe obstructive sleep apnea pooled results from two multicenter randomized controlled trials. Sleep Med. 2022 Jan;89:71-77. doi: 10.1016/j.sleep.2021.11.009. Epub 2021 Nov 24.
Clinical trial NCT00357526: Oral Contraceptive Pills Compared to Vaginal Rings
Official title: YOUNG WOMEN'S EXPERIENCES: ORAL CONTRACEPTIVE PILLS VS The VAGINAL RING
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pregnancy
Keywords: vaginal ring
Oral contraceptive pills
Teenagers
Young women
Patient satisfaction
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
Collaborators: name: Organon
First posted: 2006-07-27
Enrollment: 130
Sex: FEMALE
Minimum age (years): 15
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether teens and young women would prefer the Nuvaring to oral contraceptive pills after having tried both methods.

Detailed description: Sexually active young women (n=130), aged 15-21 years, were randomly assigned to use either the vaginal ring or oral contraceptive pills for an initial study interval of three 28-day cycles, followed by three cycles of the alternate method. Participants completed surveys about method use, acceptability and side effects at baseline, after three cycles, and after six cycles, as well as in a follow up telephone interview one month after study completion.

Eligibility criteria: Inclusion Criteria:

* Sexually active young women (n=130), English or Spanish speaking, aged 15-21 years, able and willing to try oral contraceptives and vaginal rings for 6 months

Exclusion Criteria:

* Not able or willing to use hormonal contraceptives, moving out of the area, pregnant or intending to become pregnant during the study time frame, not sexually active

Primary outcomes:
measure: Satisfaction
Secondary outcomes:
measure: Compliance
measure: Acceptability
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: New Generation Health Center
state: California
Study officials:
affiliation: University of California, San Francisco
name: Felicia Stewart, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05210426: The Effects of Pilates on Posture and Physical Fitness Parameters in 5-6 Years Old Children
Official title: The Effects of Pilates on Posture and Physical Fitness Parameters in 5-6 Years Old Children: a Non-randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Posture
Physical Fitness
Keywords: Pilates
Posture
Child
Physical Fitness
Preschool
Lead sponsor: Aydin Adnan Menderes University
Sponsor class: OTHER
Collaborators: name: Pamukkale University
First posted: 2022-01-27
Enrollment: 66
Sex: ALL
Minimum age (years): 5
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this non-randomized controlled study was to investigate the effects of Pilates on posture and physical fitness parameters in 5-6 years old healthy children.

As a result of this study, pilates can be applied as an alternative exercise that improves posture and physical fitness in children.

Detailed description: The purpose of this non-randomized controlled study was to investigate the effects of Pilates on posture and physical fitness parameters in 5-6 years old healthy children.

As a result of this study, pilates can be applied as an alternative exercise that improves posture and physical fitness in children.

This study will answer whether pilates practice has an effect on posture and whether pilates has an effect on physical fitness parameters.Demographic information of the participants was recorded. Postural assessments were evaluated by the New York Posture Rating (NYPR) chart test and fitness was evaluated by the Eurofit test battery.

Eligibility criteria: Inclusion Criteria:

* Attending Aydın Bahçeşehir Kindergarten,
* Being allowed by her family to participate in the study
* Being a volunteer,
* Not having a diagnosed physical or mental illness that would prevent her from exercising.

Exclusion Criteria:

* Not being a volunteer,
* Having a health problem that prevents exercise.

Primary outcomes:
measure: New York Posture Rating
timeFrame: immediately after application
measure: Eurofit test battery
timeFrame: immediately after application
Secondary outcomes:
Other outcomes:
Locations:
city: Aydın
country: Turkey
facility: Bahcesehir Preschool
state: Efeler
Study officials:
References:
citation: Ozturk N, Unver F. The effects of pilates on posture and physical fitness parameters in 5-6 years old children: A non-randomized controlled study. J Bodyw Mov Ther. 2022 Jul;31:153-158. doi: 10.1016/j.jbmt.2022.03.009. Epub 2022 Mar 20.
Clinical trial NCT00731926: Effect of Antioxidant on Endurance Performance in Healthy Men
Official title: Effect of Antioxidant on Endurance Performance in Healthy Men -Double Blind Randomized Placebo and Active Controlled Trial-
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Exercise Tolerance
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: University of California, Davis
First posted: 2008-08-11
Enrollment: 69
Sex: MALE
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: oligomerized litchi fruit extract may enhance the submaximal endurance exercise performance

Detailed description: Regular physical exercise has many beneficial effects, but it has been reported that strenuous exercise could elevate the production of free radical and other reactive oxygen species (ROS) which eventually injure the tissues and decrease the muscle function.So many kinds of antioxidant supplementations have been tried to decrease the muscle fatigue and enhance the exercise performance. polyphenolic flavonoids abundant in fruits and leafy vegetables have strong antioxidant effect. oligomerized litchi fruit extract has strong antioxidant capacity and higher bioavailability compared to that of grape seed polyphenol. The aim of this study was to determine whether oligomerized litchi fruit extract could induce endurance exercise performance more than Vit C + Vit E mixture or placebo could do. Therefore, we designed double blind randomized controlled trial, setting the change of running time to exhaustion under submaximal treadmill test as the primary endpoint.

Eligibility criteria: Inclusion Criteria:

* healthy men over 20 years old non-smoker

Exclusion Criteria:

* BMI\>25 or body fat\>25% he who intakes the antioxidant supplement in recent 2 weeks

Primary outcomes:
measure: change of running time to exhaustion under 80% of maximal heart rate
timeFrame: 1 month
Secondary outcomes:
measure: VO2max, anaerobic threshold
timeFrame: 1 month
Other outcomes:
Locations:
Study officials:
affiliation: Institute of Complementary Alternative Medicine SNUMC
name: Sang-chul Lee, professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02475226: Cases With Traumatic and Non Traumatic Brain Damage Treated in the Intensive Care
Official title: Distribution and Mortality Factors of Cases With Traumatic and Non Traumatic Brain Damage Treated in Intensive Care; Retrospective Clinical Trial
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Brain Injuries
Keywords: Traumatic Brain Injury
Brain Damage
Mortality
C10.228.140.199
Lead sponsor: Umraniye Education and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2015-06-18
Enrollment: 135
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: a total of 1004 patients treated in the ICU in a 2-year period were retrospectivly reviewed. 135 patients, determined with traumatic or nontraumatic brain damage, with a more than 24-hour stay in the ICU, included the study.

Brief summary: Cases of traumatic and nontraumatic brain damage have high rates of morbidity and mortality. In this study of cases being treated in the ICU for a diagnosis of brain damage, it was aimed to evaluate the relationship between mortality and the distribution of reason for and resulting type of brain damage and to determine other factors affecting mortality.

Detailed description: After local ethics committee approval, a total of 1004 patients treated in the ICU in a 2-year period were retrospectively reviewed. 135 patients, determined with traumatic or nontraumatic brain damage, with a more than 24-hour stay in the ICU, included the study. Reasons for brain damage were determined as brain damage associated with pure head trauma (Group HT), head trauma accompanying general body trauma (Group HT+GBT) and spontaneous haemorrhage (Group SH). The type of brain damage was defined from the radiological diagnosis as subarachnoid haemorrhage, intracranial haemorrhage (ICH), subdural haematoma(SDH), epidural haematoma(EDH), skull fracture, brain contusion or a combination of these (COM).

Eligibility criteria: Inclusion Criteria:

* Patients treated in the ICU with the diagnose of traumatic or nontraumatic brain damage, with a more than 24-hour stay.

Exclusion Criteria:

* Patients admitted less than 24 hour.

Primary outcomes:
measure: number of patients by brain damage types
timeFrame: 2 years
Secondary outcomes:
measure: Number of factors effecting the mortality
timeFrame: 2 years
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul Umraniye Education and Research Hospital
Study officials:
affiliation: Umraniye Education and Research Hospital
name: Nurten Bakan, MD
role: STUDY_CHAIR
References:
citation: Sacco S, Marini C, Toni D, Olivieri L, Carolei A. Incidence and 10-year survival of intracerebral hemorrhage in a population-based registry. Stroke. 2009 Feb;40(2):394-9. doi: 10.1161/STROKEAHA.108.523209. Epub 2008 Nov 26.
citation: Schwarz S, Hafner K, Aschoff A, Schwab S. Incidence and prognostic significance of fever following intracerebral hemorrhage. Neurology. 2000 Jan 25;54(2):354-61. doi: 10.1212/wnl.54.2.354.
Clinical trial NCT00018226: Effect Of Case Management Following Discharge From Methadone Treatment
Official title: Enhanced Outreach Counseling Following Methadone Treatment Discharge
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Opioid-Related Disorders
Lead sponsor: VA Office of Research and Development
Sponsor class: FED
First posted: 2001-07-05
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this project is to assess whether enhanced outreach counseling (EOC) is an effective outreach strategy for discharged methadone maintenance patients compared to a standard referral procedure. EOC is a brief (30 minute) face-to-face intervention, followed by six weeks of ongoing telephone counseling/case management designed to help eligible out-of-treatment methadone patients re-enter treatment. Several studies have shown those patients who voluntarily re-enter treatment improve significantly following re-enrollment.


Eligibility criteria: Patients who have been discharged from methadone maintenance treatment at the PVAMC who consented (as active patients) to be contacted for follow-up upon discharge.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Drug Dependent Treatment Unit
state: Pennsylvania
Study officials:
References:
Clinical trial NCT01199926: Effect of Vitamin D Supplementation on Muscle Mass and Function
Official title: Impact of Vitamin D Supplementation on Strength and Lean Mass Accumulation During an Exercise Intervention
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Obesity
Insulin Resistance
Inflammation
Keywords: 25-hydroxyvitamin D
Parathyroid hormone
Lean mass
Muscular strength
Glucose tolerance
Lead sponsor: Purdue University
Sponsor class: OTHER
First posted: 2010-09-13
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The study was designed to assess the effects of vitamin D supplementation during exercise training on body composition, muscle function, and glucose tolerance. The investigators hypothesis for these studies is that vitamin D supplementation enhances exercise-induced increases in strength and lean mass, potentially through enhancing insulin sensitivity and reducing inflammation.

Detailed description: The study was designed to assess the effects of vitamin D supplementation during exercise training on body composition, muscle function, and glucose tolerance. It was a double-blind, randomized, placebo-controlled, clinical trial with participants randomized into either a 4,000 IU/day vitamin D or placebo group and all participants completed 12 wks (3 d/wk) of exercise training.

Eligibility criteria: Inclusion Criteria:

* Physical activity scores in the "low" to "very low" category
* Fitness estimations in the "below average" or lower categories
* body mass index scores \>24.9 indicating overweight or obesity.

Exclusion Criteria:

* Use of tanning booths or other artificial UV light exposure
* High baseline vitamin D and calcium intake
* Plans to visit sunny/warm destinations during the winter months/study period
* History or presence of metabolic disease, type 2 diabetes, eating disorders, gastrointestinal disorders, pregnancy or lactation
* Use of drugs to treat obesity (last 12 weeks)
* Use of over the counter anti-obesity agents (last 12 weeks)
* Recent initiation of an exercise program (last four weeks).

Primary outcomes:
measure: Muscle Function
timeFrame: three months
measure: Glucose Tolerance
timeFrame: three months
measure: Inflammation
timeFrame: three months
Secondary outcomes:
Other outcomes:
Locations:
city: West Lafayette
country: United States
facility: Wastl Human Performance Laboratory, Purdue University
state: Indiana
Study officials:
affiliation: Purdue University
name: Dorothy Teegarden, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: College of Charleston
name: Michael G Flynn, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Carrillo AE, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Clin Nutr. 2013 Jun;32(3):375-81. doi: 10.1016/j.clnu.2012.08.014. Epub 2012 Aug 31.
Clinical trial NCT02952326: Comparing Between XP Endo Finisher and Conventional Irrigation Method On Post-Operative Flare Ups In Necrotic Teeth
Official title: Comparison Of The Effect of Adding XP Endo Finisher To The Irrigation Protocol Versus Conventional Irrigation Method On Post-Operative Flare Ups In Necrotic Teeth
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Dental Pulp Necroses
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2016-11-02
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Comparing the postoperative flare ups and pain after adding the XP Endo Finisher to the final irrigation protocol on necrotic mandibular premolars.

Detailed description: patients are randomized into 2 groups after meeting the eligibility criteria,

1. Each patient will be given pain scale chart in order to record his /her pain level before any intervention.
2. The tooth is anesthetized, accessed and mechanical instrumentation to be made 3 A) For the experimental group: The canals will be thoroughly irrigated using 3ml syringe of 2.5% Sodium hypochlorite between every subsequent instrument. XP Endo finisher is used after the last instrument in preparation

B) For the control group :

The canals will be thoroughly irrigated using 3ml syringe of 2.5% Sodium hypochlorite between every subsequent instrument.

4) Obturation is done and postoperative instructions are given to the patient

Eligibility criteria: Inclusion Criteria:

i. Age between 18-50 years old. ii. Males or Females. iii. mandibular Premolars

* Asymptomatic.
* Non-vital response of pulp tissue (negative response).
* With or without periapical radiolucency.

Exclusion Criteria:

i. Patients allergic to penicillin. ii. Pregnant females. iii. Patients having significant systemic disorder. iv. If antibiotics have been administrated during the past two weeks preoperatively.

v. Patients having bruxism or clenching. vi. Teeth that have :

* Vital pulp tissues.
* Association with swelling
* Acute peri-apical abscess
* Periodontally affected teeth
* No possible restorability
* Previous endodontic treatment.

Primary outcomes:
measure: Post-operative pain recorded by the patient using a four step pain scale (0-3)
timeFrame: up to 5 days after the treatment
Secondary outcomes:
measure: Post-operative swelling
timeFrame: up to 5 days after the treatment
measure: Need\ number of Analgesic tablets
timeFrame: up to 5 days after the treatment
measure: Need for systemic antibiotics
timeFrame: up to 5 days after the treatment
Other outcomes:
Locations:
Study officials:
References:
citation: Elnaghy AM, Mandorah A, Elsaka SE. Effectiveness of XP-endo Finisher, EndoActivator, and File agitation on debris and smear layer removal in curved root canals: a comparative study. Odontology. 2017 Apr;105(2):178-183. doi: 10.1007/s10266-016-0251-8. Epub 2016 May 20.
citation: Siqueira JF Jr. Microbial causes of endodontic flare-ups. Int Endod J. 2003 Jul;36(7):453-63. doi: 10.1046/j.1365-2591.2003.00671.x.