Clinical trial NCT03612440: Effects of Dexmedetomidine on OI, RI and Inflammatory Factors in Patients Undergoing Palatopalatyngoplasty.
Official title: Effects of Dexmedetomidine on Oxygenation Index, Respiratory Index and Inflammatory Factors in Patients Undergoing Palatopalatyngoplasty
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Adverse Effect
Keywords: dexmedetomidine
oxygenation index
respiratory index
inflammatory factors
Lead sponsor: General Hospital of Ningxia Medical University
Sponsor class: OTHER
First posted: 2018-08-02
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The purpose of this study is to investigate the efficacy of dexmedetomidine on oxygenation index, respiratory index and inflammatory factors, and to explore the protective effect of the dexmedetomidine on respiratory function in patients undergoing palatopalatyngoplasty.

Detailed description: Obstructive sleep apnea syndrome is common among people, especially among obese people, Which is characterized by periodic or complete upper airway obstruction and hypoxia during sleep. Intermittent hypoxia contributes to the lung damage by increased oxidative stress, inflammation. Some researchers suggested that dexmedetomidine can inhibit inflammatory reaction and lessen the damage of respiratory function. The aim of this study is to investigate the efficacy of dexmedetomidine on oxygenation index, respiratory index and inflammatory factors, and to explore the protective effect of the dexmedetomidine on respiratory function in patients undergoing palatopalatyngoplasty.

Eligibility criteria: Inclusion Criteria:

* Patients undergoing palatopalatyngoplasty
* ASA physical status II-III
* Aged 18-65 years
* BMI 18.5-30kg/m2

Exclusion Criteria:

* Bradycardia
* Atrioventricular block
* Allergic to the drugs
* Complicating pulmonary disease(including pulmonary infection,COPD, asthma and so on)

Primary outcomes:
measure: The Oxygenation Index
timeFrame: Intraoperative and immediately after surgery
measure: The Respiratory Index
timeFrame: Intraoperative and immediately after surgery
Secondary outcomes:
measure: Change of tumor necrosis factor-α before anesthesia and immediately after surgery
timeFrame: Intraoperative and immediately after surgery
measure: Change of interleukin-6 before anesthesia and immediately after surgery
timeFrame: Intraoperative and immediately after surgery
measure: Change of interleukin-10 before anesthesia and immediately after surgery
timeFrame: Intraoperative and immediately after surgery
Other outcomes:
Locations:
city: Yinchuan
country: China
facility: General Hospital of Ningxia Medical University
state: Ningxia
Study officials:
affiliation: General Hospital of Ningxia Medical University
name: Li Na
role: PRINCIPAL_INVESTIGATOR
References:
citation: Li N, Zhang Y, Yang F, Zhang H, Yu X, Lu K, Wang J, Ma H, Ni X. Effects of dexmedetomidine on oxygenation and inflammatory factors in patients undergoing uvulopalatopharyngoplasty: a prospective, randomized, placebo-controlled trial. Sleep Breath. 2023 Jun;27(3):1099-1106. doi: 10.1007/s11325-022-02711-1. Epub 2022 Sep 27.