louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03092401: Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study
Official title: Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hepatopulmonary Syndrome
Liver Cirrhosis
Keywords: Liver transplantation
Hepatopulmonary Syndrome
Liver Cirrhosis
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2017-03-27
Enrollment: 142
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients who underwent liver transplantation between 2010 and 2016

Brief summary: Hepatopulmonary Syndrome is a respiratory complication of liver cirrhosis defined as a triad: hypoxemia (PaO2 \< 80 mmHg in room air), chronic liver disease and intrapulmonary vasodilatations. Its prevalence varies between 4 and 32%. Numerous treatments have been tried but the only efficient therapy to cure the syndrome is liver transplantation. Without transplantation it is associated with a higher mortality which is the reason why hepatopulmonary syndrome patients have a higher priority to transplantation. However it appears in some restricted studies that hepatopulmonary syndrome is associated with more postoperative complications (infections, vascular and biliary complications, prolonged length of mechanical ventilation...).

The investigators hypothesised that hepatopulmonary syndrome patients have more postoperative complications after liver transplantation than non hepatopulmonary syndrome patients matched on age, MELD (Model for End-Stage Liver Disease) score, comorbidities, perioperative transfusion and noradrenaline doses.


Eligibility criteria: Inclusion Criteria:

* Liver transplanted patients

Exclusion Criteria:

* Living donor transplantation
* Bipartition transplantation
* Non-heat-beating donor transplantation
* Minor
* Double or multiple organ transplantation
* Non cirrhotic patients
* Retransplantation

Primary outcomes:
measure: Postoperative complication rates in hepatic transplant patients with or without hepatopulmonary syndrome
timeFrame: 1 year post liver transplantation
Secondary outcomes:
measure: Length of Mechanical Ventilation
timeFrame: 1 year post liver transplantation
measure: Length of ICU stay
timeFrame: 1 year post liver transplantation
measure: Length of Hospital Stay
timeFrame: 1 year post liver transplantation
measure: Delay of hepatopulmonary syndrome resolution
timeFrame: 1 year post liver transplantation
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05633901: Impact of Preop Video on Patient Anxiety
Official title: Evaluation of Preoperative Counseling Video on Anxiety in Patients Undergoing Vaginal Prolapse Surgery
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Prolapse, Vaginal
Prolapse, Uterine
Prolapse; Female
Keywords: Anxiety
Video
Prolapse
Urogynecology
Lead sponsor: TriHealth Inc.
Sponsor class: OTHER
First posted: 2022-12-01
Enrollment: 160
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: To determine whether a pre-operative educational video has an impact on the anxiety of patients undergoing vaginal prolapse surgery


Eligibility criteria: Inclusion Criteria:

* Prolapse surgery may include: apical repair with uterosacral ligament suspension, or sacrospinous/iliococcygeal ligament fixation, or sacrocolpopexy.
* They may also have a concomitant total vaginal hysterectomy with or without bilateral salpingectomy/oophorectomy, other compartment repairs for prolapse, or a suburethral sling for incontinence.
* Surgery by one of the fellowship trained Urogynecologists at TriHealth
* Age \>= 18
* English speaking
* Able to comprehend and answer the survey completely.

Exclusion Criteria:

* Concomitant procedure with another surgeon
* Resides in a nursing home
* Non-English speaking
* Patients with mental disability, Alzheimer's disease, dementia that would preclude complete answering of the survey or inability to answer the questions.

Primary outcomes:
measure: Pre-operative anxiety level in each group, as measured with the Surgical Anxiety Questionnaire.
timeFrame: Immediately Pre-op
Secondary outcomes:
measure: To assess a difference in anxiety levels, based on Surgical Anxiety Questionnaire score, in patients currently taking medication for anxiety
timeFrame: Immediately Pre-op
measure: To assess a difference in anxiety levels, based on Surgical Anxiety Questionnaire score, in patients that did or did not watch the video at home
timeFrame: Immediately Pre-op
Other outcomes:
Locations:
city: Cincinnati
country: United States
facility: Cincinnati Urogynecology Associates
state: Ohio
city: Cincinnati
country: United States
facility: Good Samaritan Hospital
state: Ohio
Study officials:
References:
Clinical trial NCT04453501: Anti Infective Agents Impact in COVID-19 Pneumonia
Official title: Interest of Azithromycin With or Without Hydroxychloroquine for the Treatment of COVID-19 Pneumonia : a Retrospective Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID
Pneumonia, Viral
Keywords: azithromycin
hydroxychloroquine
COVID-19
pneumonia
hospitalization
Lead sponsor: Centre d'Investigation Clinique et Technologique 805
Sponsor class: OTHER
First posted: 2020-07-01
Enrollment: 132
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients admitted at Hopital Raymond Poincaré, Garches, France in a medical ward for a COVID-19 pneumonia

Brief summary: During COVID-19 epidemic, hydroxychloroquine was proposed and authorized as a possible key agent in the treatment of COVID-19 hospitalized pneumonia, including in France. Gautret et al. proposed the combination regimen with azithromycin. However only one study reported the interest of azithromycin alone.

Retrospective study reporting the impact of the anti-infective agents used during the pandemic in a tertiary care hospital, using azithromycin with or without hydroxychloroquine.


Eligibility criteria: Inclusion Criteria:

* aged over 18 years old
* hospitalized for a COVID-19 pneumonia documented by PCR or lung tomodensitometry,
* admitted outside an intensive care unit, in a medicine ward

Exclusion Criteria:

* patient opposed to data collected, or who could not consent because of a serious presentation of the pneumonia

Primary outcomes:
measure: Favorable outcome
timeFrame: Assessed within 7 days after admission
Secondary outcomes:
measure: Risk factors 1
timeFrame: Assessed at day 1
measure: Risk factors 2
timeFrame: Assessed at day 1
measure: Interest of anti-infective agents
timeFrame: From date of inclusion until the date of first documented progression to ICU or date of death from any cause, whichever came first, assessed up to 2 months
Other outcomes:
Locations:
city: Garches
country: France
facility: Benjamin Davido
Study officials:
References:
Clinical trial NCT03322501: Pediatric Health Promotion Program
Official title: Pediatric Health Promotion Program
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tobacco Use
Lead sponsor: Georgetown University
Sponsor class: OTHER
First posted: 2017-10-26
Enrollment: 350
Sex: ALL
Minimum age (years): 13
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The purpose of the study is to determine if an Ask, Advise, Connect (AAC) intervention model benefits tobacco control outcomes for pediatric primary care providers (pPCP's) and their young patients.


Eligibility criteria: Inclusion Criteria:

* Well-child visit

Exclusion Criteria:

-

Primary outcomes:
measure: Tobacco Use
timeFrame: 1 Month
Secondary outcomes:
Other outcomes:
Locations:
city: Washington
country: United States
facility: MedStar Georgetown University Hospital
state: District of Columbia
Study officials:
References:
Clinical trial NCT02068001: Changes in Food Preference and Food Cue Responsivity After Bariatric Surgery
Official title: Changes in Food Preference and Food Cue Responsivity After Bariatric Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Roux-en-Y Gastric Bypass
Lead sponsor: Wageningen University
Sponsor class: OTHER
Collaborators: name: Rijnstate Hospital
First posted: 2014-02-20
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Morbidly obese individuals (age 18-55 years) scheduled for Roux-en-Y gastric bypass surgery at Rijnstate hospital, Arnhem

Brief summary: It has been suggested that obese people are more sensitive to sensory and rewarding effects of food, aspects that mediate food preferences and intake. Individuals that underwent Roux-en-Y gastric bypass surgery frequently report changes in food preference. They indicate a decreased preference for highly rewarding energy dense foods. Changes in food preference might be related to alterations in central (brain) mechanisms, related to reward sensing. The smell and sight of food can be considered as anticipatory cues for the rewarding effects of food intake. The aim of this study is to determine the effect of gastric bypass surgery on (alterations in) food preferences. Secondly, this study aims at assessing the effect of gastric bypass surgery on the brain reward response when exposed to sight and smell of food stimuli with different sugar and fat contents.


Eligibility criteria: Inclusion Criteria:

* Scheduled for Roux-en-Y Gastric Bypass Surgery at Rijnstate hospital

Exclusion Criteria:

* Lack of appetite
* Having difficulties swallowing/eating
* Being a vegetarian
* Allergic to food product used as stimuli in the study

Primary outcomes:
measure: Development of food preferences after Roux-en-Y gastric bypass surgery
timeFrame: Participants will be followed for two years after they undergo surgery
measure: Change in brain reward response to food cues
timeFrame: Before and 2 months after surgery
Secondary outcomes:
measure: Plasma levels of endocannabinoids and satiety hormones
timeFrame: Before and 2 months after surgery
Other outcomes:
measure: Descriptives
timeFrame: Before surgery
measure: Appetite ratings
timeFrame: During fMRI measurements, i.e., before and two months after surgery
measure: Olfactory performance
timeFrame: At each fMRI measurement, i.e., before and two months after surgery
measure: Development of BMI
timeFrame: Before and after surgery
Locations:
city: Arnhem
country: Netherlands
facility: Rijnstate Hospital
state: Gelderland
city: Ede
country: Netherlands
facility: Gelderse Vallei Hospital
state: Gelderland
city: Wageningen
country: Netherlands
facility: Wageningen University
state: Gelderland
Study officials:
affiliation: Wageningen University
name: Suzanne EM de Bruijn, MSc
role: PRINCIPAL_INVESTIGATOR
affiliation: Wageningen University
name: Harriët FA Zoon, MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01228201: Physical Exercise and Coronary Artery Plaque Composition
Official title: Physical Exercise and Coronary Artery Plaque Composition
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Coronary Artery Disease
Lead sponsor: Trondheim University Hospital
Sponsor class: OTHER
Collaborators: name: Norwegian University of Science and Technology
First posted: 2010-10-26
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to examine the effect of two different physical exercise protocols on changes in coronary artery plaque composition and development of in-stent restenosis in patients treated with percutaneous coronary intervention with stent implantation. The investigators will compare aerobic interval training and moderate continuous training. Both exercise protocols have a duration of 12 weeks. The investigators hypothesize that aerobic interval training is superior to moderate continuous training regarding effects on the composition of coronary artery plaques and a reduction in the development of in-stent restenosis.


Eligibility criteria: Inclusion Criteria:

* stable or unstable coronary artery disease treated with percutaneous coronary intervention with stent implantation,
* informed patient consent

Exclusion Criteria:

* ST-elevation myocardial infarction,
* inability to give informed consent,
* inability to participate in regular training due to residency, work situation or comorbidity,
* any known chronic inflammatory disease other than atherosclerosis,
* planned surgery within the next four months

Primary outcomes:
measure: Artery plaque composition evaluated by intravascular ultrasound and virtual histology
timeFrame: After 12 weeks
Secondary outcomes:
measure: Occurrence of in-stent restenosis related to endothelial dysfunction, inflammatory biomarkers and the dimension of the main left coronary artery
timeFrame: After 12 weeks
Other outcomes:
Locations:
city: Trondheim
country: Norway
facility: Department of Cardiology
Study officials:
affiliation: Department of Cardiology, Trondheim University Hospital
name: Rune Wiseth, M.D, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Munk PS, Staal EM, Butt N, Isaksen K, Larsen AI. High-intensity interval training may reduce in-stent restenosis following percutaneous coronary intervention with stent implantation A randomized controlled trial evaluating the relationship to endothelial function and inflammation. Am Heart J. 2009 Nov;158(5):734-41. doi: 10.1016/j.ahj.2009.08.021.
citation: Taraldsen MD, Wiseth R, Videm V, Bye A, Madssen E. Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise. Physiol Genomics. 2022 Apr 1;54(4):129-140. doi: 10.1152/physiolgenomics.00071.2021. Epub 2022 Feb 28.
Clinical trial NCT06360601: Intravenous Labetalol Versus Hydralazine in Preeclampsia
Official title: The Effect of Intravenous Infusion of Labetalol Versus Hydralazine on Cerebral Hemodynamics of Preeclampsia Patients Prospective Randamized Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE1
PHASE2
Conditions: Preeclampsia Severe
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2024-04-11
Enrollment: 40
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: We study the effect of intravenous labetalol versus hydralazine in sever preeclampsia patients on cerebral blood flow and neurological outcome


Eligibility criteria: Inclusion Criteria:

* patient with clinical diagnosis of sever preeclampsia

Exclusion Criteria:

Patient with history of previous intracranial lesion Patient with history of heart disease/allergy to drug Patient with history of arrhythmia/anticoagulation Any craniotemporal lesion

-

Primary outcomes:
measure: Cerebral blood flow
timeFrame: Pre intervention-after one hour of intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Tanta Univeristy hospitals
Study officials:
References:
Clinical trial NCT06035601: EHR-integrated rUTI Texting Platform
Official title: An EHR-integrated Texting Platform to Promote Self-management in Women With Recurrent Urinary Tract Infections
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Recurrent Urinary Tract Infection
Keywords: unnecessary antibiotics
self-management
digital platform
texting
implementation science
recurrent UTI
healthcare utilization
patient education
Lead sponsor: University of Pennsylvania
Sponsor class: OTHER
Collaborators: name: Independence Blue Cross
First posted: 2023-09-13
Enrollment: 104
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The goal of this clinical trial is to compare a texting platform to usual care for managing recurrent urinary tract infections (UTI).

The main question it aims to answer is:

• can a texting platform that integrates symptom triage and prevention education reduce the rate of unnecessary antibiotics for recurrent UTIs as compared to usual care?

Participants enrolled onto the texting platform will:

• receive evidence-based clinical guidance for the management of symptoms of UTI and receive educational videos on how to prevent UTIs. An important secondary outcome is to determine if the texting platform improves self-efficacy for the management of recurrent UTI.


Eligibility criteria: Inclusion Criteria:

1. Provision of signed and dated informed consent form
2. Stated willingness to comply with all study procedures and availability for the duration of the study
3. Females who currently meet the criteria for recurrent UTIs
4. Age 18 years or older
5. Owns a mobile device with text messaging capability
6. Ability to read and write English
7. Currently receiving care from a provider in Penn Urogynecology or Penn Urology

Exclusion criteria:

1. History of known multidrug resistant UTIs
2. History of interstitial cystitis/bladder pain syndrome or current diagnosis of chronic pelvic pain
3. On continuous suppressive antibiotics currently
4. Currently pregnant or within 6 weeks of pregnancy
5. Transplant patient on immunosuppressive medication currently
6. Practice of chronic self-catheterization

Primary outcomes:
measure: Rate of unnecessary antibiotics
timeFrame: 3 months
Secondary outcomes:
measure: Patient self-efficacy
timeFrame: 3 months
measure: Patient satisfaction: Patient Global Impression of Improvement score
timeFrame: 3 months
measure: Healthcare-related quality of life: EQ-5D-5L score
timeFrame: 3 months
measure: Healthcare-related quality of life: Recurrent UTI Impact Questionnaire score
timeFrame: 3 months
measure: Healthcare utilization
timeFrame: 3 months
measure: Antibiotic prescriptions
timeFrame: 3 months
measure: Patient medication compliance
timeFrame: 3 months
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: University of Pennsylvania
state: Pennsylvania
Study officials:
References:
Clinical trial NCT06337201: A Digital Life Story to Support Person-centred Care for Older Adults With Dementia Perspectives
Official title: A Digital Life Story to Support Person-centred Care for Older Adults With Dementia: Healthcare Professionals' Perspectives
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cognitive Impairment
Dementia
Lead sponsor: Blekinge Institute of Technology
Sponsor class: OTHER
First posted: 2024-03-29
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthcare professionals working in daycare center and residential care.

Brief summary: Person-centred care can be supported when healthcare professionals access and actively use the information recorded in a life story. Active use of the life story can create security for a person with dementia and their carers. The written life story describes the person and their life experiences, which can define the person's identity. National guidelines for care and nursing in dementia and Blekinge's regional guidelines emphasise the importance of care and nursing for people with dementia, which should be given with a person-centred approach, where the life story becomes a tool for healthcare professionals. Research shows that a life story can be designed in several ways. For example, in book form, as a brochure, collage, memory box or electronically. The life story is also intended as a tool for healthcare professionals to create security and facilitate communication with the individual. As more and more older adults are using computers and tablets as assistive devices, and it is also becoming more common for healthcare professionals to use, for example, tablets as assistive devices in nursing care, the life story could be shared in digital form as an application and become a living document.

Overall aim: To test an application for the life story with the intention of supporting person-centred care for older adults with dementia and to test whether the application can replace the written completion document. Study I: Exploring the research area of the life story in digital form. Study II: Focus group interviews with healthcare professionals. Study III: Test the application, Min Memoria. Study IV: Observations on the use of the application.


Eligibility criteria: Inclusion Criteria:

* Healthcare professionals using a life story in daily care.

Exclusion Criteria:

* N/A

Primary outcomes:
measure: Healthcare professionals' experiences using a written life story in the daily care of older adults with dementia
timeFrame: From October 2023 - August 2024
measure: Data on the use of a digital life story tool.
timeFrame: September 2024 - August 2025
measure: Observation when using a digital life story
timeFrame: September 2025 - December 2026
Secondary outcomes:
Other outcomes:
Locations:
city: Karlskrona
country: Sweden
facility: Blekinge Institute of Technology
state: Blekinge
Study officials:
References: