louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04478929: Early Detection of Barrett's Esophagus Through Deep Image Retrieval
Official title: Early Detection of Cancer in Cases of Barrett's Esophagus Using Robotic Endoscopy Image Analysis Through Deep Image Retrieval
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Barrett Esophagus
Lead sponsor: University of the West of England
Sponsor class: OTHER
Collaborators: name: Cancer Research UK
First posted: 2020-07-21
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Attending NBT clinic for on OGD phase 1, then later attending NBT clinic due to suspected Barrett's.

Brief summary: Barrett's oesophagus is a condition in which the area between the oesophagus and stomach no longer closes, allowing acidic contents of the stomach to enter the oesophagus and damage the lining. The project aims to assist clinicians by offering informed biopsy process, in which the system presents the operator with clinical outcomes of patients with visually similar GI tracts. The project goal is to assess the use of artificial intelligence-based similarity detection systems to better inform biopsy placement, increasing the reliability of bi-yearly inspections.

Detailed description: The project intention is to acquire secondary endoscopy captured data from clinicians to create a sufficient dataset to train a learning system to achieve the stated objective. The data required will feature footage (images/videos) from inside the oesophagus. The preferred data would contain associated diagnosis notes and description, however, data without diagnosis can still be used. All data can and will be anonymised, as personal information will not be useful in this work.

The data will be labelled by either researchers, or professional clinicians and prepared ready to feed into a chosen learning AI system. Through an iterative learning process, the chosen AI system will learn to discriminate between severity of Barrett's oesophagus and output optimal biopsy target.

Eligibility criteria: Inclusion Criteria:

* Adult
* Attending Southmead Hospital for on OGD
* Has capacity
* Initially any indication, later patients with known Barrett's oesophagus

Exclusion Criteria:

* Children (\<18)
* Patients without capacity
* Urgent and emergency procedures
* Limited English

Primary outcomes:
measure: gastroscopy image data set
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Bristol
country: United Kingdom
facility: NBT, Southmead Hospital
state: Avon
Study officials:
References:
Clinical trial NCT01293929: Association of Circulating Chemerin Levels and Arterial Stiffness
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Obesity
Atherosclerosis
Lead sponsor: Korea University
Sponsor class: OTHER
First posted: 2011-02-11
Enrollment: 120
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Obese and age, gender matched non-obese group who underwent a medical health check in the Korea University Guro hospital

Brief summary: Chemerin is a novel adipokine that might provide a link between chronic inflammation and obesity. Pulse wave velocity(PWV) is a useful method for examining arterial stiffness, meaning early-stage atherosclerosis. Therefore, in the present study, the investigators examined the relationship between circulating chemerin and arterial stiffness measured using PWV in obese persons.


Eligibility criteria: Inclusion Criteria:

* Self referred persons for visiting routine medical check in our clinic

Exclusion Criteria:

* Malignancy
* Severe renal or hepatic disease

Primary outcomes:
measure: The difference of serum chemerin level between obese and non-obese groups
timeFrame: at the time of initial enrollment (4weeks)
Secondary outcomes:
measure: The correlation of serum chemerin levels with arterial stiffness
timeFrame: at the time of enrollment (4 weeks)
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Hye Jin Yoo
Study officials:
References:
Clinical trial NCT04372329: Promoting the Use of CPAP Therapy Among OSA Patients
Official title: A Tailored Sleep Behavior Change Support System to Promote the Use of Continuous Positive Airway Pressure Therapy: Theorizing the Solution
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obstructive Sleep Apnea
Lead sponsor: Claremont Graduate University
Sponsor class: OTHER
First posted: 2020-05-04
Enrollment: 59
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: Obstructive sleep apnea (OSA) is the most common sleep breathing disorder in the U.S. Continuous Positive Airway Pressure (CPAP) therapy is the most effective treatment for OSA. However, up to 50% of patients who accept using CPAP therapy fail to adhere to it. This study will evaluate an information systems (IS)-based solution that sends tailored, motivational, educational messages and tailored feedback messages to promote CPAP usage among noncompliant OSA patients. The primary aim of this study is to determine the efficacy of the proposed IS solution and its effect on fostering the use of CPAP therapy among OSA patients.


Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of OSA
* Prescribed treatment of CPAP therapy
* Possession of a mobile phone that has multimedia messaging capabilities
* Capacity to consent.

Exclusion Criteria:

* Unable to speak and read English

Primary outcomes:
measure: Change in CPAP usage
timeFrame: During 19 weeks
measure: CPAP compliance
timeFrame: 19 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Claremont
country: United States
facility: Pomona Valley Hospital Medical Center Adults and Children Sleep Disorders Center
state: California
Study officials:
affiliation: Claremont Graduate University
name: Sarah Alismail, MS, MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06681129: Study of Normal Intestinal Development and Disease in Premature and Term Neonates
Official title: Study of Normal Intestinal Development and Disease in Premature and Term Neonates - a Pathway for the Study of Premature and Neonatal Intestinal Disorders Including the Roles of Nutrition, Microbes, and Cellular Physiology, and Diseases Including Necrotizing Enterocolitis
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: NEC
Necrotizing Enterocolitis
Intestinal Disease
Human Development
Keywords: NEC
Early Intestinal Development
Intestinal Intervention
Necrotizing Enterocolitis
Lead sponsor: Boston Children's Hospital
Sponsor class: OTHER
First posted: 2024-11-08
Enrollment: 100
Sex: ALL
Maximum age (years): 2
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Neonates or infants that are admitted to the in-patient units for intestinal intervention.

Brief summary: Current research on early intestinal development is primarily performed in mouse models. While useful in many other ways, mouse models are not ideal for studying human intestine development as the timing of this process differs between the two species. Further, prior research has demonstrated that some proteins and pathways that are critical in human development have no clear role in mice.

This study aims to improve the overall understanding of critical aspects of intestinal development in humans. In addition, this study will investigate the impact of intestinal diseases that are found in the early stages of life such as necrotizing enterocolitis (NEC).


Eligibility criteria: Inclusion Criteria:

* Any neonate or infant through 2 years of age having intestinal surgery or intestinal biopsies from an esophogastroduodenoscopy (EGD) or colonoscopy.

Exclusion Criteria:

* Children \> 2 years of age.
* Infants 0-2 years old not undergoing GI surgery or intestinal scope with biopsy procedure.

Primary outcomes:
measure: Number of intestinal stem cells and mature epithelial cells
timeFrame: At the time of surgery for another clinical problem.
measure: Degree of Immune System Changes
timeFrame: Within 48 hours before or after the clinically-driven surgery.
measure: Fraction of Stool Microbiome that has beneficial microbes
timeFrame: Within 48 hours before or after the surgery from which the biopsy is obtained.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Boston Children's Hospital
name: Amy O'Connell, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02536729: Evaluation of the Quality of Life of Patients Requiring Intestinal Cleansing Using Oral Medications to Imaging Procedure by Patient Reported Outcome
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Bowel Preparation
Lead sponsor: Fundación Salutia
Sponsor class: OTHER
Collaborators: name: Tecnoquimicas S.A
First posted: 2015-09-01
Enrollment: 600
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults who are in diagnostic centers, which have order for an imaging procedure that requires intestinal cleansing conducted.

Brief summary: Objective: The primary objective of this study is to assess the quality of life of people treated with oral phosphate compared with polyethylene glycol + electrolytes to imaging procedures, according to the outcome variables reported by patients.

Type of study: A non-interventional observational analytic prospective cohort study.

Sample: We will include people who need bowel cleansing for the realization of imaging tests

Exposures: - oral sodium phosphate normal regimen

* Oral sodium phosphate with modified diet
* Polyethylene Glycol + electrolytes

Follow-up time: 8 days after the bowel preparation

Outcomes: Boston Scale measure Safety Differences between groups in blood test (Sodium, Potassium, Calcium)


Eligibility criteria: Inclusion Criteria:

* Patients which have order for an imaging procedure that requires bowel cleansing
* Older than 18 years and younger than 65 years old
* Accept to participate in this study

Primary outcomes:
measure: Boston scale for bowel cleansing
timeFrame: 2 days
Secondary outcomes:
measure: Number of adverse events
timeFrame: 8 days
measure: Quality of life
timeFrame: 8 days
measure: Blood creatinine
timeFrame: 8 days
measure: Blood urea nitrogen (BUN)
timeFrame: 8 days
measure: Blood Sodium
timeFrame: 8 days
measure: Blood Potassium
timeFrame: 8 days
measure: Blood Calcium
timeFrame: 8 days
measure: Blood Phosphorus
timeFrame: 8 days
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06023329: Superficial Cervical Plexus Block for Improved Outcomes in Pediatric Otolaryngologic Surgery
Official title: Superficial Cervical Plexus Block for Improved Outcomes in Pediatric Otolaryngologic Surgery
Study type: INTERVENTIONAL
Overall status: SUSPENDED
Phase: PHASE4
Conditions: Otolaryngologic Surgery
Lead sponsor: University of Minnesota
Sponsor class: OTHER
First posted: 2023-09-05
Enrollment: 36
Sex: ALL
Minimum age (years): 3
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Literature on the use of superficial cervical plexus blocks for ear surgery is sparse in general, and almost non-existent in the pediatric population. Overall, literature review supports the safety of performance of this block but there is minimal published literature on its utility despite anecdotal evidence of benefit. This study, especially its prospective randomized nature will allow for expansion of the evidence for or against addition of this block to the care of pediatric patients undergoing ear surgery. The purpose of this study is to determine if SCPB plus standard practices provides superior pain control, as measured by reduced opiate consumption, compared to standard practices alone when performed on pediatric patients undergoing surgery on the ear and mastoid process.


Eligibility criteria: Inclusion Criteria:

* Age: \<18 years and \>3 months
* Surgical procedure: Unilateral cochlear implant or tympanomastoidectomy

Exclusion Criteria:

* Preoperative opiate use within the last 30 days
* Bilateral surgery
* No English speaking caregiver
* Parental/patient refusal
* Severe preoperative respiratory compromise
* Allergy to ropivacaine
* Coagulopathy: Defined by INR\&gt;1.5 or Platelet count \&lt;100k
* Current Infection at site of injection
* VP Shunt on side of surgical procedure
* Pregnant patients: determined by patient history and available laboratory data. Patients will not be required to have pregnancy testing done if not otherwise indicated.

Primary outcomes:
measure: Opioid use
timeFrame: 30 days post surgery
Secondary outcomes:
measure: intraoperative opiate use
timeFrame: 30 days post surgery
measure: post-operative opiate use
timeFrame: 30 days post surgery
measure: Pain level
timeFrame: 30 days post surgery
measure: Quality of Recovery
timeFrame: 30 days post surgery
measure: Post Anesthesia Care Unit anti-emetic use
timeFrame: 30 days post surgery
Other outcomes:
Locations:
city: Minneapolis
country: United States
facility: University of Minnesota
state: Minnesota
Study officials:
affiliation: University of Minnesota
name: Benjamin Fuller, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03953729: Effectiveness of Pre-emptive Analgesia in Children With Molar-incisor Hypomineralization (MIH)
Official title: Effectiveness of Pre-emptive Analgesia in Children With Molar-incisor Hypomineralization (MIH): Triple-blind Clinal Study, Randomized and Controlled by Placebo
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: EARLY_PHASE1
Conditions: Pain
Anxiety
Lead sponsor: University of Sao Paulo
Sponsor class: OTHER
First posted: 2019-05-17
Enrollment: 50
Sex: ALL
Minimum age (years): 6
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: SUPPORTIVE_CARE

Brief summary: Pain is defined by IASP (International Association for the Study of Pain) as "an unpleasant sensory and emotional experience associated with the damage actual or potential tissue or described in terms that suggest such harm". Episodes of pain and discomfort experienced by children are one of the main factors for fear and anxiety in dentistry, especially those that present the condition of Molar-Incisive Hipomineralization, where we observed increased levels of anxiety in relation to the treatment. In order to improve the painful sensation that patients with Molar-Incisor Hipomineralization present as well as anxiety demonstrated by these patients in face of dental treatment, the objective of present study will be to evaluate the occurrence and degree of pain after procedures dentists with administration of pre-emptive analgesia or placebo, in children with Molar-Incisive Hipomineralization. Fifty patients will be selected in the Pediatric Dentistry courses of the FORP-USP undergraduate course, aged 6 to 12 years, of both sexes, who present at least 2 (two) upper and / or lower molars affected by Molar- Incisors that need some kind of restorative treatment, extraction or endodontic treatment. Also, these patients should present enamel and dentin fractures caused by MIH, atypical restoration and / or atypical caries, and that present pain above the moderate degree (6\>), after stimulation with air/water jet for 5 seconds.


Eligibility criteria: Inclusion Criteria:

* present at least 2 (two) upper molars and/or lower affected by Molar-Incisor Hypomineralization
* restorative treatment
* extraction
* endodontic treatment
* pain above the moderate degree (6\>)

Exclusion Criteria:

* patients with suspected of analgesics of any type or presence of acute pain in the last 24 hours before the procedure
* patient with history of hepatopathy
* bleeding hemorrhagic disorders
* hypersensitivity to components
* patients and family members who do not have a telephone or that the children will not under parental supervision in the first 24 hours after care.

Primary outcomes:
measure: Visual Pain Scale
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Ribeirão Preto
country: Brazil
facility: School of Dentistry of Ribeirao Preto
state: São Paulo
Study officials:
affiliation: University of Sao Paulo, School of Dentistry of Ribeirão Preto
name: Fabrício K de Carvalho, Professor
role: STUDY_DIRECTOR
References:
Clinical trial NCT01675180: Self Reported Oral Health, Awareness and Attitude Towards Dental Care Among Pregnant Women
Official title: Self Reported Oral Health, Awareness and Attitude Towards Dental Care and Risk of Dental Caries Among Pregnant Women in Norway
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pregnancy
Oral Health
Attitude
Oxidative Stress
Keywords: pregnancy, oral health, attitude, awareness, streptococcus mutans, lactobacilli, oxidative stress
Lead sponsor: University of Tromso
Sponsor class: OTHER
Collaborators: name: University Hospital of North Norway
First posted: 2012-08-29
Enrollment: 200
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Purpose/Objective of the study:

The main objective of the study is to investigate oral health awareness and attitudes towards oral health among Norwegian pregnant women and assess the impact of information about oral hygiene on the risk of dental caries during pregnancy.

The hypothesis of the study are:

1. The state of oral health during pregnancy depends on pregnant woman's preventive oral hygiene behaviour and practice.
2. Pregnant women with high level of oral health awareness and positive attitude towards oral health are more likely to visit their dentists regularly and have better oral hygiene compared to those with less awareness.
3. Proper information and guidance on oral hygiene care provided during pregnancy can help to improve oral bacteriological milieu and reduce the dental caries risk among pregnant women.


Eligibility criteria: Inclusion Criteria:

* Women with viable pregnancy ≥ 17 weeks gestation

Exclusion Criteria:

* Those not willing to participate in the study.
* Women who are unable to communicate well in Norwegian.
* Women who have been diagnosed to have a fetus with a chromosomal or structural fetal anomaly and do not plan to continue their pregnancy

Primary outcomes:
measure: Oral health
timeFrame: In 4 weeks interval after recrutiatment of study participants
Secondary outcomes:
measure: Attitude
timeFrame: After approximately 6 months
Other outcomes:
Locations:
city: Tromsø
country: Norway
facility: Department of Obstetrics and Gynaecology, University Hospital of Northern Norway (UNN)
state: Troms
Study officials:
affiliation: University of Tromsø and University Hospital of North Norway
name: Ganesh Acharya, Professor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Wagle M, D'Antonio F, Reierth E, Basnet P, Trovik TA, Orsini G, Manzoli L, Acharya G. Dental caries and preterm birth: a systematic review and meta-analysis. BMJ Open. 2018 Mar 2;8(3):e018556. doi: 10.1136/bmjopen-2017-018556.
Clinical trial NCT05425680: Remote Intelligent Interactive Virtual Reality Assessment in Patients With Degenerative Lumbar Spine Diseases
Official title: Clinical Effectiveness and Biomechanics Study for Remote Intelligent Interactive Virtual Reality Assessment and Rehabilitation in Patients With Degenerative Lumbar Spine Diseases
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Degenerative Lumbar Spine Diseases
Keywords: degenerative lumbar spine disease
virtual reality
telehealth
real-time detection
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2022-06-21
Enrollment: 120
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study will combine virtual reality (VR) technology with machine learning to focus on functional movement. Patients' symptoms will be evaluated, and exercise instruction with real-time feedback will be provided. The goals of this research are to: (1) develop a waist digital sensor for real-time monitoring as an evaluation tool, (2) apply a real-time monitoring system in conjunction with virtual reality for telerehabilitation, and (3) develop the standard model.

Detailed description: The remote assessment and training in this study can assist patients obtaining physical therapy care at home. It is suitable for patients who avoid going to the hospital due to the epidemic, and solve the problem of long-term treatment. The outcomes will provide DLSD patients tele-rehabilitation platform and system, help medical personnel to treat patients more effectively in the future, and reduce the burden of medical costs on close ones.

Eligibility criteria: Inclusion Criteria:

1. able to stand and walk for 5 minutes independently
2. aged between 50 and 80 years
3. received a diagnosis of DLSD based on imaging

Exclusion Criteria:

1. neurological disorder such as stroke or spinal cord injury
2. metabolic disease such as diabetes mellitus
3. vestibular disease such as Meniere's disease.

Primary outcomes:
measure: Functional assessment: Walking speed
timeFrame: 6 months
measure: Functional assessment: Walking distance
timeFrame: 6 months
measure: Functional assessment: Duration
timeFrame: 6 months
measure: Postural balance
timeFrame: 6 months
measure: Kinematic variables: Joint angles
timeFrame: 6 months
measure: Kinematic variables: Center of mass
timeFrame: 6 months
measure: Kinetic variables
timeFrame: 6 months
measure: Muscle activities
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital or Movement Science Lab of National Taiwan University
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University
name: Wei-Li Hsu, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: