Clinical trial NCT03856801: Acute Effects of Whole-body Vibration Training in Hypoxia and Normoxia in Multiple Sclerosis Patients
Official title: Acute Effects of Whole-body Vibration Training in Hypoxia and Normoxia Condition on Neuromuscular Performance and Mobility in Patients With Multiple Sclerosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Multiple Sclerosis
Keywords: neuromuscular disease
whole-body vibration
hypoxia
strength
Lead sponsor: Universidad Católica San Antonio de Murcia
Sponsor class: OTHER
First posted: 2019-02-27
Enrollment: 13
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: SUPPORTIVE_CARE

Brief summary: Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Moderate intensity strength training has been shown to improve strength and mobility in persons with MS. It was suggested that whole-body vibration training (WBVT) is effective to improve muscle strength, such as resistance training, resulting from both neural and structural adaptations. On the other hand, traditional strength training in hypoxia has garnered much attention. This method has shown improvements in isometric strength and increases in muscle size.

Detailed description: * Crossover.
* 13 patients with multiple sclerosis were recruited.
* Patients performed two sessions: whole-body vibration training in normoxia condition and whole-body vibration in hypoxia condition.

Eligibility criteria: Inclusion Criteria:

* mild or moderate disability with clinical mild spastic-ataxic gait disorder.
* stable phase of the disease.

Exclusion Criteria:

* Expanded Disability Status Scale (EDSS) \< 6.
* relapsing disease within the preceding 12 months.
* corticosteroid treatment within the last months before study inclusion.

Primary outcomes:
measure: Maximal Voluntary Isometric Contraction of Knee Extension
timeFrame: Immediately before the training sessions
measure: Maximal Voluntary Isometric Contraction of Knee Extension
timeFrame: Immediately after the training sessions
measure: Rate of Force Development
timeFrame: Immediately before the training sessions
measure: Rate of Force Development
timeFrame: Immediately after the training sessions
measure: Central Activation Ratio
timeFrame: Immediately before the training sessions
measure: Central Activation Ratio
timeFrame: Immediately after the training sessions
measure: Biomechanical study of the walk by video recording
timeFrame: Immediately before the training sessions
measure: Biomechanical study of the walk by video recording
timeFrame: Immediately after the training sessions
measure: Biomechanical study of the walk by video recording
timeFrame: Immediately before the training sessions
measure: Biomechanical study of the walk by video recording
timeFrame: Immediately after the training sessions
measure: Spasticity
timeFrame: Immediately before the training sessions
measure: Spasticity
timeFrame: Immediately after the training sessions
Secondary outcomes:
measure: Rate of Perceived Exertion
timeFrame: Immediately before the training sessions
measure: Rate of Perceived Exertion
timeFrame: Immediately after the training sessions
measure: Walking speed
timeFrame: Immediately before the training sessions
measure: Walking speed
timeFrame: Immediately after the training sessions
measure: Static balance
timeFrame: Immediately before the training sessions
measure: Static balance
timeFrame: Immediately after the training sessions
measure: Muscle oxygenation in soleus
timeFrame: Immediately before the training sessions
measure: Muscle oxygenation in soleus
timeFrame: Immediately after the training sessions
Other outcomes:
Locations:
city: Murcia
country: Spain
facility: Universidad Católica San Antonio
Study officials:
References: