Clinical trial NCT01508026: Study of the Efficacy and Safety of the Combination of Two FDA Approved Oral Medications, Nebivolol and Valsartan for Treatment of Stage 1 or 2 Hypertension
Official title: A Multicenter, Randomized, Double-blind, Placebo-Controlled, 8-Week Study to Evaluate the Safety and Efficacy of Nebivolol and Valsartan Given as a Fixed Dose Combination in Patients With Stage 1 or 2 Essential Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Stage 1 Hypertension
Stage 2 Hypertension
Keywords: Stage 1
Stage 2
Hypertension
Lead sponsor: Forest Laboratories
Sponsor class: INDUSTRY
First posted: 2012-01-11
Enrollment: 4161
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To evaluate the efficacy and safety of fixed-dose combination of nebivolol and valsartan compared to monotherapy and placebo in patients with stage 1 and stage 2 hypertension.


Eligibility criteria: Inclusion Criteria:

* Male or female outpatients of age 18 years or above
* Patients diagnosed with stage 1 or stage 2 essential hypertension
* Normal physical examination findings, electrocardiogram (ECG) results and chest x-ray; or abnormal findings judged by the Investigator to be not clinically significant

Exclusion Criteria:

* Secondary hypertension or severe hypertension
* Clinically significant cardiovascular disease or heart failure
* Clinical significant respiratory disease that would prohibit the use of a beta blocker
* A medical contraindication to discontinuing a current antihypertensive therapy
* History of Type 1 diabetes mellitus
* History of Severe Mental Illness except mild depression

Primary outcomes:
measure: Change in Sitting Diastolic Blood Pressure (DBP)
timeFrame: from basline to Week 8
Secondary outcomes:
measure: Change in Sitting Systolic Blood Pressure (SBP)
timeFrame: from baseline to Week 8
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Forest Investigative Site 1750
state: Alabama
city: Birmingham
country: United States
facility: Forest Investigative Site 1038
state: Alabama
city: Birmingham
country: United States
facility: Forest Investigative Site 1308
state: Alabama
city: Birmingham
country: United States
facility: Forest Investigative Site 1192
state: Alabama
city: Birmingham
country: United States
facility: Forest Investigative Site 1005
state: Alabama
city: Foley
country: United States
facility: Forest Investigative Site 1047
state: Alabama
city: Gulf Shores
country: United States
facility: Forest Investigative Site 1717
state: Alabama
city: Mobile
country: United States
facility: Forest Investigative Site 1056
state: Alabama
city: Muscle Shoals
country: United States
facility: Forest Investigative Site 1719
state: Alabama
city: Glendale
country: United States
facility: Forest Investigative Site 1145
state: Arizona
city: Goodyear
country: United States
facility: Forest Investigative Site 1703
state: Arizona
city: Mesa
country: United States
facility: Forest Investigative Site 1757
state: Arizona
city: Phoenix
country: United States
facility: Forest Investigative Site 1170
state: Arizona
city: Phoenix
country: United States
facility: Forest Investigative Site 1238
state: Arizona
city: Phoenix
country: United States
facility: Forest Investigative Site 1204
state: Arizona
city: Phoenix
country: United States
facility: Forest Investigative Site 1755
state: Arizona
city: Phoenix
country: United States
facility: Forest Investigative Site 1259
state: Arizona
city: Phoenix
country: United States
facility: Forest Investigative Site 1001
state: Arizona
city: Scottsdale
country: United States
facility: Forest Investigative Site 1078
state: Arizona
city: Tempe
country: United States
facility: Forest Investigative Site 1225
state: Arizona
city: Tempe
country: United States
facility: Forest Investigative Site 1712
state: Arizona
city: Tempe
country: United States
facility: Forest Investigative Site 1089
state: Arizona
city: Tucson
country: United States
facility: Forest Investigative Site 1065
state: Arizona
city: Tucson
country: United States
facility: Forest Investigative Site 1340
state: Arizona
city: Tucson
country: United States
facility: Forest Investigative Site 1331
state: Arizona
city: Little Rock
country: United States
facility: Forest Investigative Site 1290
state: Arkansas
city: Little Rock
country: United States
facility: Forest Investigative Site 1138
state: Arkansas
city: Pine Bluff
country: United States
facility: Forest Investigative Site 1371
state: Arkansas
city: Searcy
country: United States
facility: Forest Investigative Site 1220
state: Arkansas
city: Buena Park
country: United States
facility: Forest Investigative Site 1063
state: California
city: Burbank
country: United States
facility: Forest Investigative Site 1743
state: California
city: Carmichael
country: United States
facility: Forest Investigative Site 1006
state: California
city: Chino
country: United States
facility: Forest Investigative Site 1384
state: California
city: Chula Vista
country: United States
facility: Forest Investigative Site 1190
state: California
city: Costa Mesa
country: United States
facility: Forest Investigative Site 1178
state: California
city: Diamond Bar
country: United States
facility: Forest Investigative Site 1043
state: California
city: Encinitas
country: United States
facility: Forest Investigative Site 1362
state: California
city: Fresno
country: United States
facility: Forest Investigative Site 1144
state: California
city: Fresno
country: United States
facility: Forest Investigative Site 1095
state: California
city: Garden Grove
country: United States
facility: Forest Investigative Site 1710
state: California
city: Greenbrae
country: United States
facility: Forest Investigative Site 1022
state: California
city: Huntington Beach
country: United States
facility: Forest Investigative Site 1370
state: California
city: Huntington Park
country: United States
facility: Forest Investigative Site 1704
state: California
city: Huntington Park
country: United States
facility: Forest Investigative Site 1725
state: California
city: La Mesa
country: United States
facility: Forest Investigative Site 1742
state: California
city: Lomita
country: United States
facility: Forest Investigative Site 1381
state: California
city: Long Beach
country: United States
facility: Forest Investigative Site 1706
state: California
city: Los Angelas
country: United States
facility: Forest Investigative Site 1248
state: California
city: Los Angelas
country: United States
facility: Forest Investigative Site 1785
state: California
city: Los Angeles
country: United States
facility: Forest Investigative Site 1029
state: California
city: Los Angeles
country: United States
facility: Forest Investigative Site 1361
state: California
city: Los Angeles
country: United States
facility: Forest Investigative Site 1102
state: California
city: Mission Hills
country: United States
facility: Forest Investigative Site 1054
state: California
city: Moreno Valley
country: United States
facility: Forest Investigative Site 1386
state: California
city: Newport Beach
country: United States
facility: Forest Investigative Site 1756
state: California
city: Northridge
country: United States
facility: Forest Investigative Site 1181
state: California
city: Orange
country: United States
facility: Forest Investigative Site 1212
state: California
city: Palm Springs
country: United States
facility: Forest Investigative Site 1101
state: California
city: Paramount
country: United States
facility: Forest Investigative Site 1014
state: California
city: Pismo Beach
country: United States
facility: Forest Investigative Site 1150
state: California
city: Riverside
country: United States
facility: Forest Investigative Site 1009
state: California
city: Roseville
country: United States
facility: Forest Investigative Site 1241
state: California
city: Sacramento
country: United States
facility: Forest Investigative Site 1046
state: California
city: Sacramento
country: United States
facility: Forest Investigative Site 1193
state: California
city: Sacramento
country: United States
facility: Forest Investigative Site 1296
state: California
city: Sacramento
country: United States
facility: Forest Investigative Site 1716
state: California
city: San Bernardino
country: United States
facility: Forest Investigative Site 1096
state: California
city: San Diego
country: United States
facility: Forest Investigative Site 1189
state: California
city: San Diego
country: United States
facility: Forest Investigative Site 1279
state: California
city: San Diego
country: United States
facility: Forest Investigative Site 1354
state: California
city: San Diego
country: United States
facility: Forest Investigative Site 1724
state: California
city: San Diego
country: United States
facility: Forest Investigative Site 1106
state: California
city: San Francisco
country: United States
facility: Forest Investigative Site 1027
state: California
city: San Marino
country: United States
facility: Forest Investigative Site 1017
state: California
city: San Ramon
country: United States
facility: Forest Investigative Site 1158
state: California
city: Santa Ana
country: United States
facility: Forest Investigative Site 1318
state: California
city: Spring Valley
country: United States
facility: Forest Investigative Site 1239
state: California
city: Stockton
country: United States
facility: Forest Investigative Site 1792
state: California
city: Sylmar
country: United States
facility: Forest Investigative Site 1301
state: California
city: Temecula
country: United States
facility: Forest Investigative Site 1066
state: California
city: Tustin
country: United States
facility: Forest Investigative Site 1729
state: California
city: Westlake Village
country: United States
facility: Forest Investigative Site 1783
state: California
city: Colorado Springs
country: United States
facility: Forest Investigative Site 1162
state: Colorado
city: Denver
country: United States
facility: Forest Investigative Site 1270
state: Colorado
city: Denver
country: United States
facility: Forest Investigative Site 1711
state: Colorado
city: Northglenn
country: United States
facility: Forest Investigative Site 1013
state: Colorado
city: Thornton
country: United States
facility: Forest Investigative Site 1400
state: Colorado
city: Bridgeport
country: United States
facility: Forest Investigative Site 1324
state: Connecticut
city: Cromwell
country: United States
facility: Forest Investigative Site 1045
state: Connecticut
city: Stamford
country: United States
facility: Forest Investigative Site 1059
state: Connecticut
city: Waterbury
country: United States
facility: Forest Investigative Site 1072
state: Connecticut
city: Boca Raton
country: United States
facility: Forest Investigative Site 1159
state: Florida
city: Bradenton
country: United States
facility: Forest Investigative Site 1007
state: Florida
city: Brandon
country: United States
facility: Forest Investigative Site 1042
state: Florida
city: Brooksville
country: United States
facility: Forest Investigative Site 1702
state: Florida
city: Clearwater
country: United States
facility: Forest Investigative Site 1764
state: Florida
city: Coral Gables
country: United States
facility: Forest Investigative Site 1182
state: Florida
city: Coral Gables
country: United States
facility: Forest Investigative Site 1249
state: Florida
city: Cutler Bay
country: United States
facility: Forest Investigative Site 1221
state: Florida
city: Daytona Beach
country: United States
facility: Forest Investigative Site 1793
state: Florida
city: Deerfield Beach
country: United States
facility: Forest Investigative Site 1266
state: Florida
city: DeFuniak Springs
country: United States
facility: Forest Investigative Site 1100
state: Florida
city: Deland
country: United States
facility: Forest Investigative Site 1734
state: Florida
city: Doral
country: United States
facility: Forest Investigative Site 1775
state: Florida
city: Doral
country: United States
facility: Forest Investigative Site 1378
state: Florida
city: Edgewater
country: United States
facility: Forest Investigative Site 1237
state: Florida
city: Fort Lauderdale
country: United States
facility: Forest Investigative Site 1068
state: Florida
city: Fort Lauderdale
country: United States
facility: Forest Investigative Site 1330
state: Florida
city: Ft. Lauderdale
country: United States
facility: Forest Investigative Site 1026
state: Florida
city: Gainsville
country: United States
facility: Forest Investigative Site 1794
state: Florida
city: Hallandale Beach
country: United States
facility: Forest Investigative Site 1261
state: Florida
city: Hialeah
country: United States
facility: Forest Investigative Site 1240
state: Florida
city: Hialeah
country: United States
facility: Forest Investigative Site 1260
state: Florida
city: Hollywood
country: United States
facility: Forest Investigative Site 1155
state: Florida
city: Jacksonville
country: United States
facility: Forest Investigative Site 1233
state: Florida
city: Jacksonville
country: United States
facility: Forest Investigative Site 1253
state: Florida
city: Jacksonville
country: United States
facility: Forest Investigative Site 1264
state: Florida
city: Jacksonville
country: United States
facility: Forest Investigative Site 1256
state: Florida
city: Jupiter
country: United States
facility: Forest Investigative Site 1077
state: Florida
city: Kissimmee
country: United States
facility: Forest Investigative Site 1041
state: Florida
city: Kissimmee
country: United States
facility: Forest Investigative Site 1399
state: Florida
city: Miami Springs
country: United States
facility: Forest Investigative Site 1297
state: Florida
city: Miami
country: United States
facility: Forest Investigative Site 1784
state: Florida
city: Miami
country: United States
facility: Forest Investigative Site 1364
state: Florida
city: Miami
country: United States
facility: Forest Investigative Site 1206
state: Florida
city: Miami
country: United States
facility: Forest Investigative Site 1397
state: Florida
city: Miami
country: United States
facility: Forest Investigative Site 1180
state: Florida
city: Miami
country: United States
facility: Forest Investigative Site 1396
state: Florida
city: Miami
country: United States
facility: Forest Investigative Site 1154
state: Florida
city: Miami
country: United States
facility: Forest Investigative Site 1788
state: Florida
city: Miami
country: United States
facility: Forest Investigative Site 1223
state: Florida
city: Miami
country: United States
facility: Forest Investigative Site 1707
state: Florida
city: Miami
country: United States
facility: Forest Investigative Site 1282
state: Florida
city: New Port Richey
country: United States
facility: Forest Investigative Site 1708
state: Florida
city: North Miami Beach
country: United States
facility: Forest Investigative Site 1176
state: Florida
city: Oldsmar
country: United States
facility: Forest Investigative Site 1284
state: Florida
city: Opa-Locka
country: United States
facility: Forest Investigative Site 1232
state: Florida
city: Orlando
country: United States
facility: Forest Investigative Site 1802
state: Florida
city: Orlando
country: United States
facility: Forest Investigative Site 1049
state: Florida
city: Orlando
country: United States
facility: Forest Investigative Site 1235
state: Florida
city: Ormond Beach
country: United States
facility: Forest Investigative Site 1741
state: Florida
city: Oviedo
country: United States
facility: Forest Investigative Site 1003
state: Florida
city: Palm Harbor
country: United States
facility: Forest Investigative Site 1369
state: Florida
city: Pembroke Pines
country: United States
facility: Forest Investigative Site 1079
state: Florida
city: Pembroke Pines
country: United States
facility: Forest Investigative Site 1053
state: Florida
city: Pembroke Pines
country: United States
facility: Forest Investigative Site 1055
state: Florida
city: Pembroke Pines
country: United States
facility: Forest Investigative Site 1161
state: Florida
city: Pembroke Pines
country: United States
facility: Forest Investigative Site 1166
state: Florida
city: Pembroke Pines
country: United States
facility: Forest Investigative Site 1224
state: Florida
city: Pembroke Pines
country: United States
facility: Forest Investigative Site 1075
state: Florida
city: Pinellas Park
country: United States
facility: Forest Investigative Site 1368
state: Florida
city: Plant City
country: United States
facility: Forest Investigative Site 1023
state: Florida
city: Ponte Vedra
country: United States
facility: Forest Investigative Site 1737
state: Florida
city: Port Orange
country: United States
facility: Forest Investigative Site 1749
state: Florida
city: South Miami
country: United States
facility: Forest Investigative Site 1739
state: Florida
city: St. Cloud
country: United States
facility: Forest Investigative Site 1069
state: Florida
city: St. Cloud
country: United States
facility: Forest Investigative Site 1315
state: Florida
city: St. Petersburg
country: United States
facility: Forest Investigative Site 1243
state: Florida
city: St. Petersburg
country: United States
facility: Forest Investigative Site 1723
state: Florida
city: St. Petersburg
country: United States
facility: Forest Investigative Site 1730
state: Florida
city: Tamarack
country: United States
facility: Forest Investigative Site 1076
state: Florida
city: Tampa
country: United States
facility: Forest Investigative Site 1032
state: Florida
city: Tampa
country: United States
facility: Forest Investigative Site 1302
state: Florida
city: Winter Haven
country: United States
facility: Forest Investigative Site 1120
state: Florida
city: Atlanta
country: United States
facility: Forest Investigative Site 1281
state: Georgia
city: Atlanta
country: United States
facility: Forest Investigative Site 1745
state: Georgia
city: Blue Ridge
country: United States
facility: Forest Investigative Site 1080
state: Georgia
city: Lilburn
country: United States
facility: Forest Investigative Site 1236
state: Georgia
city: Marietta
country: United States
facility: Forest Investigative Site 1389
state: Georgia
city: Marietta
country: United States
facility: Forest Investigative Site 1002
state: Georgia
city: Oakwood
country: United States
facility: Forest Investigative Site 1390
state: Georgia
city: Sandy Springs
country: United States
facility: Forest Investigative Site 1333
state: Georgia
city: Savannah
country: United States
facility: Forest Investigative Site 1332
state: Georgia
city: Snellville
country: United States
facility: Forest Investigative Site 1252
state: Georgia
city: Snellville
country: United States
facility: Forest Investigative Site 1353
state: Georgia
city: Stockbridge
country: United States
facility: Forest Investigative Site 1740
state: Georgia
city: Woodstock
country: United States
facility: Forest Investigative Site 1173
state: Georgia
city: Honolulu
country: United States
facility: Forest Investigative Site 1018
state: Hawaii
city: Blackfoot
country: United States
facility: Forest Investigative Site 1398
state: Idaho
city: Boise
country: United States
facility: Forest Investigative Site 1727
state: Idaho
city: Hayden Lake
country: United States
facility: Forest Investigative Site 1387
state: Idaho
city: Meridian
country: United States
facility: Forest Investigative Site 1004
state: Idaho
city: Nampa
country: United States
facility: Forest Investigative Site 1039
state: Idaho
city: Addison
country: United States
facility: Forest Investigative Site 1790
state: Illinois
city: Arlington Heights
country: United States
facility: Forest Investigative Site 1093
state: Illinois
city: Chicago
country: United States
facility: Forest Investigative Site 1747
state: Illinois
city: Chicago
country: United States
facility: Forest Investigative Site 1071
state: Illinois
city: Chicago
country: United States
facility: Forest Investigative Site 1752
state: Illinois
city: Hazel Crest
country: United States
facility: Forest Investigative Site 1403
state: Illinois
city: Morton
country: United States
facility: Forest Investigative Site 1126
state: Illinois
city: O'Fallon
country: United States
facility: Forest Investigative Site 1283
state: Illinois
city: Evansville
country: United States
facility: Forest Investigative Site 1091
state: Indiana
city: Evansville
country: United States
facility: Forest Investigative Site 1103
state: Indiana
city: Muncie
country: United States
facility: Forest Investigative Site 1147
state: Indiana
city: Augusta
country: United States
facility: Forest Investigative Site 1107
state: Kansas
city: Hutchinson
country: United States
facility: Forest Investigative Site 1345
state: Kansas
city: Lenexa
country: United States
facility: Forest Investigative Site 1805
state: Kansas
city: Mission
country: United States
facility: Forest Investigative Site 1255
state: Kansas
city: Newton
country: United States
facility: Forest Investigative Site 1092
state: Kansas
city: Crestview Hills
country: United States
facility: Forest Investigative Site 1801
state: Kentucky
city: Lexington
country: United States
facility: Forest Investigative Site 1366
state: Kentucky
city: Louisville
country: United States
facility: Forest Investigative Site 1770
state: Kentucky
city: Madisonville
country: United States
facility: Forest Investigative Site 1177
state: Kentucky
city: Baton Rouge
country: United States
facility: Forest Investigative Site 1251
state: Louisiana
city: Covington
country: United States
facility: Forest Investigative Site 1215
state: Louisiana
city: Eunice
country: United States
facility: Forest Investigative Site 1274
state: Louisiana
city: Metairie
country: United States
facility: Forest Investigative Site 1323
state: Louisiana
city: Metairie
country: United States
facility: Forest Investigative Site 1795
state: Louisiana
city: New Orleans
country: United States
facility: Forest Investigative Site 1285
state: Louisiana
city: New Orleans
country: United States
facility: Forest Investigative Site 1779
state: Louisiana
city: Auburn
country: United States
facility: Forest Investigative Site 1769
state: Maine
city: Baltimore
country: United States
facility: Forest Investigative Site 1125
state: Maryland
city: Baltimore
country: United States
facility: Forest Investigative Site 1263
state: Maryland
city: Lutherville
country: United States
facility: Forest Investigative Site 1128
state: Maryland
city: Haverhill
country: United States
facility: Forest Investigative Site 1726
state: Massachusetts
city: Hyannis
country: United States
facility: Forest Investigative Site 1061
state: Massachusetts
city: North Dartmouth
country: United States
facility: Forest Investigative Site 1728
state: Massachusetts
city: Watertown
country: United States
facility: Forest Investigative Site 1356
state: Massachusetts
city: Chelsea
country: United States
facility: Forest Investigative Site 1336
state: Michigan
city: Flint
country: United States
facility: Forest Investigative Site 1097
state: Michigan
city: Kalamazoo
country: United States
facility: Forest Investigative Site 1165
state: Michigan
city: Stevensville
country: United States
facility: Forest Investigative Site 1337
state: Michigan
city: Traverse City
country: United States
facility: Forest Investigative Site 1768
state: Michigan
city: Troy
country: United States
facility: Forest Investigative Site 1064
state: Michigan
city: Belzoni
country: United States
facility: Forest Investigative Site 1025
state: Mississippi
city: Jackson
country: United States
facility: Forest Investigative Site 1057
state: Mississippi
city: Olive Branch
country: United States
facility: Forest Investigative Site 1034
state: Mississippi
city: Picayune
country: United States
facility: Forest Investigative Site 1271
state: Mississippi
city: Kansas City
country: United States
facility: Forest Investigative Site 1782
state: Missouri
city: St. Louis
country: United States
facility: Forest Investigative Site 1250
state: Missouri
city: Missoula
country: United States
facility: Forest Investigative Site 1326
state: Montana
city: Bellevue
country: United States
facility: Forest Investigative Site 1028
state: Nebraska
city: Fremont
country: United States
facility: Forest Investigative Site 1388
state: Nebraska
city: Fremont
country: United States
facility: Forest Investigative Site 1313
state: Nebraska
city: Omaha
country: United States
facility: Forest Investigative Site 1035
state: Nebraska
city: Omaha
country: United States
facility: Forest Investigative Site 1016
state: Nebraska
city: Omaha
country: United States
facility: Forest Investigative Site 1254
state: Nebraska
city: Omaha
country: United States
facility: Forest Investigative Site 1148
state: Nebraska
city: Henderson
country: United States
facility: Forest Investigative Site 1044
state: Nevada
city: Henderson
country: United States
facility: Forest Investigative Site 1052
state: Nevada
city: Las Vegas
country: United States
facility: Forest Investigative Site 1011
state: Nevada
city: Las Vegas
country: United States
facility: Forest Investigative Site 1376
state: Nevada
city: Las Vegas
country: United States
facility: Forest Investigative Site 1019
state: Nevada
city: Las Vegas
country: United States
facility: Forest Investigative Site 1807
state: Nevada
city: Las Vegas
country: United States
facility: Forest Investigative Site 1048
state: Nevada
city: Edison
country: United States
facility: Forest Investigative Site 1709
state: New Jersey
city: Haddon Heights
country: United States
facility: Forest Investigative Site 1132
state: New Jersey
city: Linden
country: United States
facility: Forest Investigative Site 1141
state: New Jersey
city: Paramus
country: United States
facility: Forest Investigative Site 1227
state: New Jersey
city: Trenton
country: United States
facility: Forest Investigative Site 1169
state: New Jersey
city: Union
country: United States
facility: Forest Investigative Site 1338
state: New Jersey
city: Albuquerque
country: United States
facility: Forest Investigative Site 1761
state: New Mexico
city: Brooklyn
country: United States
facility: Forest Investigative Site 1796
state: New York
city: Buffalo
country: United States
facility: Forest Investigative Site 1151
state: New York
city: Glen Falls
country: United States
facility: Forest Investigative Site 1021
state: New York
city: Rochester
country: United States
facility: Forest Investigative Site 1115
state: New York
city: Asheboro
country: United States
facility: Forest Investigative Site 1040
state: North Carolina
city: Burlington
country: United States
facility: Forest Investigative Site 1073
state: North Carolina
city: Cary
country: United States
facility: Forest Investigative Site 1142
state: North Carolina
city: Charlotte
country: United States
facility: Forest Investigative Site 1733
state: North Carolina
city: Charlotte
country: United States
facility: Forest Investigative Site 1067
state: North Carolina
city: Dunn
country: United States
facility: Forest Investigative Site 1342
state: North Carolina
city: Greensboro
country: United States
facility: Forest Investigative Site 1088
state: North Carolina
city: Greensboro
country: United States
facility: Forest Investigative Site 1385
state: North Carolina
city: Greensboro
country: United States
facility: Forest Investigative Site 1309
state: North Carolina
city: Hickory
country: United States
facility: Forest Investigative Site 1306
state: North Carolina
city: Hickory
country: United States
facility: Forest Investigative Site 1098
state: North Carolina
city: Lenoir
country: United States
facility: Forest Investigative Site 1110
state: North Carolina
city: Mooresville
country: United States
facility: Forest Investigative Site 1272
state: North Carolina
city: Raleigh
country: United States
facility: Forest Investigative Site 1024
state: North Carolina
city: Raleigh
country: United States
facility: Forest Investigative Site 1789
state: North Carolina
city: Salisbury
country: United States
facility: Forest Investigative Site 1715
state: North Carolina
city: Shelby
country: United States
facility: Forest Investigative Site 1123
state: North Carolina
city: Wilmington
country: United States
facility: Forest Investigative Site 1081
state: North Carolina
city: Wilmington
country: United States
facility: Forest Investigative Site 1705
state: North Carolina
city: Winston-Salem
country: United States
facility: Forest Investigative Site 1319
state: North Carolina
city: Winston-Salem
country: United States
facility: Forest Investigative Site 1405
state: North Carolina
city: Winston-Salem
country: United States
facility: Forest Investigative Site 1778
state: North Carolina
city: Akron
country: United States
facility: Forest Investigative Site 1203
state: Ohio
city: Canal Fulton
country: United States
facility: Forest Investigative Site 1210
state: Ohio
city: Cincinnati
country: United States
facility: Forest Investigative Site 1012
state: Ohio
city: Cincinnati
country: United States
facility: Forest Investigative Site 1721
state: Ohio
city: Cincinnati
country: United States
facility: Forest Investigative Site 1280
state: Ohio
city: Cincinnati
country: United States
facility: Forest Investigative Site 1798
state: Ohio
city: Cincinnati
country: United States
facility: Forest Investigative Site 1732
state: Ohio
city: Cincinnati
country: United States
facility: Forest Investigative Site 1718
state: Ohio
city: Cincinnati
country: United States
facility: Forest Investigative Site 1062
state: Ohio
city: Cincinnati
country: United States
facility: Forest Investigative Site 1050
state: Ohio
city: Cleveland
country: United States
facility: Forest Investigative Site 1084
state: Ohio
city: Columbus
country: United States
facility: Forest Investigative Site 1765
state: Ohio
city: Columbus
country: United States
facility: Forest Investigative Site 1395
state: Ohio
city: Delaware
country: United States
facility: Forest Investigative Site 1209
state: Ohio
city: Lyndhurst
country: United States
facility: Forest Investigative Site 1201
state: Ohio
city: Maumee
country: United States
facility: Forest Investigative Site 1246
state: Ohio
city: Mt. Gilead
country: United States
facility: Forest Investigative Site 1135
state: Ohio
city: Perrysburg
country: United States
facility: Forest Investigative Site 1322
state: Ohio
city: Willoughby
country: United States
facility: Forest Investigative Site 1231
state: Ohio
city: Zanesville
country: United States
facility: Forest Investigative Site 1713
state: Ohio
city: Norman
country: United States
facility: Forest Investigative Site 1195
state: Oklahoma
city: Oklahoma City
country: United States
facility: Forest Investigative Site 1184
state: Oklahoma
city: Oklahoma City
country: United States
facility: Forest Investigative Site 1305
state: Oklahoma
city: Oklahoma City
country: United States
facility: Forest Investigative Site 1759
state: Oklahoma
city: Yukon
country: United States
facility: Forest Investigative Site 1392
state: Oklahoma
city: Ashland
country: United States
facility: Forest Investigative Site 1116
state: Oregon
city: Eugene
country: United States
facility: Forest Investigative Site 1379
state: Oregon
city: Eugene
country: United States
facility: Forest Investigative Site 1780
state: Oregon
city: Hillsboro
country: United States
facility: Forest Investigative Site 1108
state: Oregon
city: Portland
country: United States
facility: Forest Investigative Site 1294
state: Oregon
city: Bensalem
country: United States
facility: Forest Investigative Site 1109
state: Pennsylvania
city: Bensalem
country: United States
facility: Forest Investigative Site 1291
state: Pennsylvania
city: Broomall
country: United States
facility: Forest Investigative Site 1090
state: Pennsylvania
city: Carnegie
country: United States
facility: Forest Investigative Site 1218
state: Pennsylvania
city: Downington
country: United States
facility: Forest Investigative Site 1163
state: Pennsylvania
city: Erie
country: United States
facility: Forest Investigative Site 1118
state: Pennsylvania
city: Erie
country: United States
facility: Forest Investigative Site 1171
state: Pennsylvania
city: Holland
country: United States
facility: Forest Investigative Site 1383
state: Pennsylvania
city: Jenkintown
country: United States
facility: Forest Investigative Site 1720
state: Pennsylvania
city: Lansdale
country: United States
facility: Forest Investigative Site 1207
state: Pennsylvania
city: Norristown
country: United States
facility: Forest Investigative Site 1314
state: Pennsylvania
city: Penndel
country: United States
facility: Forest Investigative Site 1198
state: Pennsylvania
city: Philadelphia
country: United States
facility: Forest Investigative Site 1293
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Forest Investigative Site 1137
state: Pennsylvania
city: Red Lion
country: United States
facility: Forest Investigative Site 1247
state: Pennsylvania
city: Tipton
country: United States
facility: Forest Investigative Site 1791
state: Pennsylvania
city: Upper St. Clair
country: United States
facility: Forest Investigative Site 1196
state: Pennsylvania
city: Warminster
country: United States
facility: Forest Investigative Site 1172
state: Pennsylvania
city: West Chester
country: United States
facility: Forest Investigative Site 1278
state: Pennsylvania
city: Warwick
country: United States
facility: Forest Investigative Site 1375
state: Rhode Island
city: Charleston
country: United States
facility: Forest Investigative Site 1760
state: South Carolina
city: Charleston
country: United States
facility: Forest Investigative Site 1363
state: South Carolina
city: Columbia
country: United States
facility: Forest Investigative Site 1122
state: South Carolina
city: Greenville
country: United States
facility: Forest Investigative Site 1133
state: South Carolina
city: Greenville
country: United States
facility: Forest Investigative Site 1809
state: South Carolina
city: Greer
country: United States
facility: Forest Investigative Site 1327
state: South Carolina
city: Mt. Pleasant
country: United States
facility: Forest Investigative Site 1127
state: South Carolina
city: Murrells Inlet
country: United States
facility: Forest Investigative Site 1310
state: South Carolina
city: Pelzer
country: United States
facility: Forest Investigative Site 1152
state: South Carolina
city: Simpsonville
country: United States
facility: Forest Investigative Site 1114
state: South Carolina
city: Spartanburg
country: United States
facility: Forest Investigative Site 1149
state: South Carolina
city: Summerville
country: United States
facility: Forest Investigative Site 1113
state: South Carolina
city: Union
country: United States
facility: Forest Investigative Site 1806
state: South Carolina
city: Dakota Dunes
country: United States
facility: Forest Investigative Site 1185
state: South Dakota
city: Rapid City
country: United States
facility: Forest Investigative Site 1753
state: South Dakota
city: Bristol
country: United States
facility: Forest Investigative Site 1402
state: Tennessee
city: Chattanooga
country: United States
facility: Forest Investigative Site 1037
state: Tennessee
city: Clarksville
country: United States
facility: Forest Investigative Site 1031
state: Tennessee
city: Collierville
country: United States
facility: Forest Investigative Site 1074
state: Tennessee
city: Fayetteville
country: United States
facility: Forest Investigative Site 1033
state: Tennessee
city: Kingsport
country: United States
facility: Forest Investigative Site 1763
state: Tennessee
city: Knoxville
country: United States
facility: Forest Investigative Site 1744
state: Tennessee
city: Memphis
country: United States
facility: Forest Investigative Site 1358
state: Tennessee
city: Memphis
country: United States
facility: Forest Investigative Site 1082
state: Tennessee
city: Arlington
country: United States
facility: Forest Investigative Site 1094
state: Texas
city: Austin
country: United States
facility: Forest Investigative Site 1245
state: Texas
city: Austin
country: United States
facility: Forest Investigative Site 1311
state: Texas
city: Beaumont
country: United States
facility: Forest Investigative Site 1174
state: Texas
city: Boerne
country: United States
facility: Forest Investigative Site 1762
state: Texas
city: Bryan
country: United States
facility: Forest Investigative Site 1244
state: Texas
city: Carrollton
country: United States
facility: Forest Investigative Site 1776
state: Texas
city: Corpus Christi
country: United States
facility: Forest Investigative Site 1205
state: Texas
city: Corsicana
country: United States
facility: Forest Investigative Site 1268
state: Texas
city: Dallas
country: United States
facility: Forest Investigative Site 1213
state: Texas
city: Houston
country: United States
facility: Forest Investigative Site 1228
state: Texas
city: Houston
country: United States
facility: Forest Investigative Site 1372
state: Texas
city: Houston
country: United States
facility: Forest Investigative Site 1777
state: Texas
city: Houston
country: United States
facility: Forest Investigative Site 1157
state: Texas
city: Houston
country: United States
facility: Forest Investigative Site 1360
state: Texas
city: Houston
country: United States
facility: Forest Investigative Site 1230
state: Texas
city: Houston
country: United States
facility: Forest Investigative Site 1774
state: Texas
city: Irving
country: United States
facility: Forest Investigative Site 1262
state: Texas
city: Longview
country: United States
facility: Forest Investigative Site 1229
state: Texas
city: New Braunfels
country: United States
facility: Forest Investigative Site 1199
state: Texas
city: Plano
country: United States
facility: Forest Investigative Site 1214
state: Texas
city: San Antonio
country: United States
facility: Forest Investigative Site 1129
state: Texas
city: San Antonio
country: United States
facility: Forest Investigative Site 1766
state: Texas
city: San Antonio
country: United States
facility: Forest Investigative Site 1797
state: Texas
city: San Antonio
country: United States
facility: Forest Investigative Site 1295
state: Texas
city: San Antonio
country: United States
facility: Forest Investigative Site 1167
state: Texas
city: San Antonio
country: United States
facility: Forest Investigative Site 1186
state: Texas
city: San Antonio
country: United States
facility: Forest Investigative Site 1257
state: Texas
city: San Antonio
country: United States
facility: Forest Investigative Site 1317
state: Texas
city: San Antonio
country: United States
facility: Forest Investigative Site 1758
state: Texas
city: Sugar Land
country: United States
facility: Forest Investigative Site 1334
state: Texas
city: Tomball
country: United States
facility: Forest Investigative Site 1269
state: Texas
city: Waco
country: United States
facility: Forest Investigative Site 1349
state: Texas
city: Clinton
country: United States
facility: Forest Investigative Site 1015
state: Utah
city: Draper
country: United States
facility: Forest Investigative Site 1187
state: Utah
city: Draper
country: United States
facility: Forest Investigative Site 1226
state: Utah
city: Magna
country: United States
facility: Forest Investigative Site 1086
state: Utah
city: Ogden
country: United States
facility: Forest Investigative Site 1216
state: Utah
city: Orem
country: United States
facility: Forest Investigative Site 1219
state: Utah
city: Riverton
country: United States
facility: Forest Investigative Site 1328
state: Utah
city: Salt Lake City
country: United States
facility: Forest Investigative Site 1771
state: Utah
city: Salt Lake City
country: United States
facility: Forest Investigative Site 1175
state: Utah
city: Salt Lake City
country: United States
facility: Forest Investigative Site 1197
state: Utah
city: Salt Lake City
country: United States
facility: Forest Investigative Site 1194
state: Utah
city: South Jordan
country: United States
facility: Forest Investigative Site 1202
state: Utah
city: St. George
country: United States
facility: Forest Investigative Site 1773
state: Utah
city: Arlington
country: United States
facility: Forest Investigative Site 1786
state: Virginia
city: Arlington
country: United States
facility: Forest Investigative Site 1130
state: Virginia
city: Burke
country: United States
facility: Forest Investigative Site 1020
state: Virginia
city: Danville
country: United States
facility: Forest Investigative Site 1343
state: Virginia
city: Manassas
country: United States
facility: Forest Investigative Site 1164
state: Virginia
city: Norfolk
country: United States
facility: Forest Investigative Site 1767
state: Virginia
city: Petersburg
country: United States
facility: Forest Investigative Site 1292
state: Virginia
city: Suffolk
country: United States
facility: Forest Investigative Site 1131
state: Virginia
city: Virginia Beach
country: United States
facility: Forest Investigative Site 1099
state: Virginia
city: Port Orchard
country: United States
facility: Forest Investigative Site 1119
state: Washington
city: Seattle
country: United States
facility: Forest Investigative Site 1394
state: Washington
city: Spokane
country: United States
facility: Forest Investigative Site 1085
state: Washington
city: Walla Walla
country: United States
facility: Forest Investigative Site 1335
state: Washington
city: Charleston
country: United States
facility: Forest Investigative Site 1377
state: West Virginia
city: Milwaukee
country: United States
facility: Forest Investigative Site 1367
state: Wisconsin
Study officials:
affiliation: Forest Laboratories
name: David B Bharucha, MD, PhD, FACC
role: STUDY_DIRECTOR
References:
citation: Giles TD, Weber MA, Basile J, Gradman AH, Bharucha DB, Chen W, Pattathil M; NAC-MD-01 Study Investigators. Efficacy and safety of nebivolol and valsartan as fixed-dose combination in hypertension: a randomised, multicentre study. Lancet. 2014 May 31;383(9932):1889-98. doi: 10.1016/S0140-6736(14)60614-0.