Clinical trial NCT06009965: Efficacy of IST Combined With TPO-RA in the Treatment of AA and Establishment of a Recurrence Prediction System
Official title: Establishment of an Efficacy and Relapse Prediction System for Immunosuppressants Combined With Thrombopoietin Receptor Agonists in the Treatment of Aplastic Anemia
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE4
Conditions: Aplastic Anemia
CSA
Drug Therapy
Keywords: Aplastic Anemia
CsA
ATG
TPO-RA
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2023-08-24
Enrollment: 210
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: In this study, investigators intend to prospectively study treatment-naive AA patients (including SAA and NSAA) who are non-transplant candidates in northern China. Patients with SAA receive ATG+CsA+Herombopag, and patients with NSAA receive CsA+ Herombopag. Investigators explored possible indicators of participants' predictive efficacy and built predictive models. After the participants achieved response, they used a tapering regimen, observed relapse and clonal evolution, and developed a predictive model of relapse.

Detailed description: 1) Patients in the SAA group: CsA: 3-5mg/kg/day, monitor the trough concentration every month, and maintain the trough concentration at 100-200ng/ml. ATG: rabbit anti-thymocyte immunoglobulin (r-ATG) 3mg/kg/d×5 days, or porcine anti-lymphocyte immunoglobulin ((p-ATG) 25mg/kg/d×5 days; TPO-RA: Herombopag starts at 7.5 mg qd, monitor the blood picture every 2 weeks, if the effect is not good, add 1 tablet every 2 weeks, up to 6 tablets (15 mg) qd.

Patients in the NSAA group: CsA: 3-5mg/kg/day, monitor the trough concentration every month, and maintain the trough concentration at 100-200ng/ml. TPO-RA: start with 7.5mg qd of Herombopag, monitor the blood picture every 2 weeks, if the effect is not good, add 1 tablet every 2 weeks, up to 6 tablets (15mg) qd.

(2) Those who are effective after 6 months of treatment continue to receive sufficient CsA treatment for at least 1.5 years, and then slowly reduce the dose until the end of the reduction. Those who fail to withdraw from the clinical trial.

(3) Participants who achieve CR or PR after treatment, but when the curative effect does not increase after 3 months of maintenance treatment, start to reduce the dose of Herombopag, and reduce one tablet every 3 months until the reduction stops. If recurrence occurs, recover Up to the last dose or even increase the dose, after reaching the best curative effect, reduce one tablet every 3 months until the reduction stops, and those who cannot recover are defined as relapse.

Eligibility criteria: Inclusion Criteria:

1. Age: 18-75 years old, gender is not limited
2. Definite diagnosis of AA
3. No HSCT indication or unconditional HSCT
4. SAA/VSAA patients were willing to accept ATG+CsA+TPO-RA treatment, NSAA was willing to accept CsA+TPO-RA treatment, and were willing to follow up regularly
5. Baseline serum transaminase, total bilirubin and serum creatinine were less than 1.5 times the normal value
6. Baseline liver and kidney function was less than 1.5 times the normal value
7. Eastern Cancer Cooperation Group (ECOG) score status 0-2
8. Agree to sign the consent form

Exclusion Criteria:

1. Congenital AA
2. Cytogenetic evidence of clonal hematologic bone marrow disease
3. PNH clone ≥50%
4. Allergic to ATG, cyclosporine and hexapopal in the past
5. Uncontrolled infection or bleeding at enrollment
6. Received hematopoietic stem cell transplantation (HSCT) before enrollment
7. Any concomitant malignancy within 5 years, except for local skin basal cell carcinoma
8. A history of thromboembolic events, myocardial infarction, or stroke (including antiphospholipid antibody syndrome); Currently using anticoagulants
9. Pregnant or lactating women
10. Situations considered unsuitable for clinical research by other researchers

Primary outcomes:
measure: Overall response rate
timeFrame: 24 weeks after treatment
measure: 24-month recurrence rate
timeFrame: 96 weeks after treatment
Secondary outcomes:
measure: Overall response rate
timeFrame: 56 weeks after treatment
measure: 36-month recurrence rate
timeFrame: 144 weeks after treatment
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking union medical college hospital
Study officials:
affiliation: Peking Union Medical College Hospital
name: Bing Bing, PhD
role: PRINCIPAL_INVESTIGATOR
References: