Clinical trial NCT01135966: Resistance Training in Patients With Chronic Obstructive Lung Disease (COPD): Whole Body Vibration Versus Conventional Resistance Training
Official title: Resistance Training in Patients With Chronic Obstructive Lung Disease (COPD): Whole Body Vibration Versus Conventional Resistance Training
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: COPD
Keywords: COPD
Whole Body Vibration training
Conventional resistance training
Lead sponsor: University Hospital, Ghent
Sponsor class: OTHER
First posted: 2010-06-03
Enrollment: 62
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Pulmonary rehabilitation has been emerged as a recommended standard of care for patients with chronic lung disease based on a growing body of scientific evidence. A set of evidence-based guidelines were published in American College of Chest Physicians (ACCP) and the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR). Since then, the published literature in pulmonary rehabilitation has increased substantially, and other societies have published important statements about pulmonary rehabilitation (eg, the American Thoracic Society and the European Respiratory Society).

In patients with COPD, there is a strong scientific basis for implementing conventional resistance training (CRT) in addition to endurance training. Endurance training, such as walking, is a key component of pulmonary rehabilitation and improves in exercise tolerance and muscular endurance. However, this type of training may not reverse muscle weakness or atrophy. For that reason, strength training seems to be the optimum training modality to increase muscle mass and strength.

Recently, Whole-Body-Vibration (WBV) training has been promoted as an alternative for resistance training on multigym equipment. In WBV training, the subject stands on a platform that generates vertical sinusoidal vibration, during which static and dynamic exercises can be performed.

The present study is conducted to provide an answer on the following question: will a resistance training program, such as the whole body vibration, be even effective than a conventional resistance training program in patients with COPD.


Eligibility criteria: Inclusion Criteria:

* Patients with COPD candidate for pulmonary rehabilitation
* Men and female between 40 and 80 years of age
* Written informed consent to participate

Exclusion Criteria:

* Severe cardiac, neurological and orthopedic co-morbidity interfering with exercise training.
* Pacemaker
* Hip, knee of shoulder prosthesis or recently introduced spirals, metal pens, bolts or plates
* Uncontrolled diabetes, epilepsy or migraine
* Osteoporotic or metastatic fractures, acute hernia, discopathy, spondylitis

Primary outcomes:
measure: estimation of the change of 6 MWD before and after 12 weeks resistance training program (CRT versus WBV training)
timeFrame: before and after 12 weeks
Secondary outcomes:
measure: changes in muscle strength (quadriceps force)after CRT or after WBV training in patients with COPD
timeFrame: before and after 12 weeks
measure: changes in body composition after CRT or after WBV training in patients with COPD
timeFrame: before and after 12 weeks
measure: changes in maximal exercise capacity after CRT or after WBV training in patients with COPD
timeFrame: before and after 12 weeks
measure: changes in muscle force after CRT or after WBV training in patients with COPD
timeFrame: before and after 12 weeks
measure: changes in Quality of life after CRT or after WBV training in patients with COPD
timeFrame: beforer and after 12 weeks
measure: changes in Dyspnea scores after CRT or after WBV training in patients with COPD
timeFrame: before and after 12 weeks
measure: changes in 6MWD and the endurance test on the bicycle after CRT or after WBV training in patients with COPD
timeFrame: before and after 12 weeks
Other outcomes:
Locations:
city: Ghent
country: Belgium
facility: University Hospital Ghent
Study officials:
affiliation: University Hospital, Ghent
name: Eric Derom, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Salhi B, Malfait TJ, Van Maele G, Joos G, van Meerbeeck JP, Derom E. Effects of Whole Body Vibration in Patients With COPD. COPD. 2015;12(5):525-32. doi: 10.3109/15412555.2015.1008693. Epub 2015 Aug 4.