Clinical trial NCT05608291: A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery
Official title: A Phase 3 Trial of Fianlimab (Anti-LAG-3) and Cemiplimab Versus Pembrolizumab in the Adjuvant Setting in Patients With Completely Resected High-risk Melanoma
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Melanoma
Keywords: Resected High Risk Melanoma
Skin Cancer
Stage IIB
Stage IIC
Stage III
Stage IV
LAG-3 Lymphocyte activation gene 3
Adjuvant Setting
anti-PD-1 Monoclonal Antibody
Lead sponsor: Regeneron Pharmaceuticals
Sponsor class: INDUSTRY
First posted: 2022-11-08
Enrollment: 1564
Sex: ALL
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is researching an experimental drug called REGN3767, also known as fianlimab (R3767), when combined with another medication called cemiplimab (each individually called a "study drug" or called "study drugs" when combined) compared with an approved medication called pembrolizumab.

The objective of this study is to see if the combination of fianlimab and cemiplimab is an effective treatment compared to pembrolizumab in patients that have had melanoma removal surgery but are still at high risk for the recurrence of the disease. Pembrolizumab is an approved treatment in some countries in this clinical setting.

The study is looking at several other research questions, including:

* What side effects may happen from receiving the study drugs.
* How much study drug is in the blood at different times.
* Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects). Antibodies are proteins that are naturally found in the blood stream that fight infections.
* How administering the study drugs might improve quality of life.


Eligibility criteria: Key Inclusion Criteria:

1. All patients must be either stage IIB, IIC, III, or stage IV per American Joint Committee on Cancer (AJCC) 8th edition and have histologically confirmed melanoma that is completely surgically resected in order to be eligible as defined by the protocol
2. Complete surgical resection must be performed within 12 weeks prior to randomization, and enrollment may occur only after satisfactory wound healing from the surgery
3. All patients must have disease-free status documented by a complete physical examination and imaging studies within 4 weeks prior to randomization, as described in the protocol

Key Exclusion Criteria:

1. Uveal melanoma
2. Any evidence of residual disease after surgery by imaging, pathology, or cytology.
3. Ongoing or recent (within 2 years) evidence of clinically significant autoimmune disease that required treatment
4. Uncontrolled infection with human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C (HCV) infection; or diagnosis of immunodeficiency that is related to, or results in chronic infection, as described in the protocol
5. Another malignancy that is currently progressing or that required active treatment in the past 5 years, as described in the protocol
6. Participants with a history of myocarditis
7. Adolescent patients (≥12 to \<18 years old) with body weight \<40 kg

Note: Other Protocol Defined Inclusion/ Exclusion Criteria Apply

Primary outcomes:
measure: Relapse free survival (RSF)
timeFrame: Up to 5 Years
Secondary outcomes:
measure: Distant metastasis-free survival (DMFS)
timeFrame: Up to 5 Years
measure: Overall survival (OS)
timeFrame: Up to 5 Years
measure: Occurrence of treatment-emergent adverse events (TEAEs)
timeFrame: Up to 5 Years
measure: Occurrence of immune-mediated EAEs (im-EAEs)
timeFrame: Up to 5 Years
measure: Occurrence of serious adverse events (SAEs)
timeFrame: Up to 5 Years
measure: Occurrence of adverse events of special interest (AESIs)
timeFrame: Up to 5 Years
measure: Occurrence of TEAEs resulting in death
timeFrame: Up to 5 Years
measure: Occurrence of dose-limiting toxicity (DLT)
timeFrame: Up to 5 Years
measure: Occurrence of interruption or discontinuation of study drug(s) due to TEAE
timeFrame: Up to 5 Years
measure: Occurrence of laboratory abnormalities
timeFrame: Up to 5 Years
measure: Concentrations of fianlimab in serum over time
timeFrame: Up to 5 Years
measure: Concentrations of cemiplimab in serum over time
timeFrame: Up to 5 Years
measure: Concentration of finalimab anti-drug antibodies (ADA) and neutralizing antibodies
timeFrame: Up to 5 Years
measure: Concentration of cemiplimab anti-drug antibodies (ADA) and neutralizing antibodies
timeFrame: Up to 5 Years
measure: Patient report outcomes (PRO) for adults as measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC-QLQ-C30)
timeFrame: Up to 5 Year
measure: PRO for adults as measured by the European Quality of Life Dimension 5 (EQ-5D-5L)
timeFrame: Up to 5 Years
measure: PRO for adults as measured by the Functional Assessment of Cancer Therapy (FACT) - melanoma
timeFrame: Up to 5 Years
measure: PRO for adults as determined by the Patient Global Impressions Scale (PGIS)
timeFrame: Up to 5 Years
measure: PRO for adults as determined by the Patient Global Impressions of Change Scale (PGIC)
timeFrame: Up to 5 Years
measure: Time to global health status/quality of life deterioration per EORTC QLQ-C30
timeFrame: Up to 5 years
measure: Time to physical functioning deterioration per EORTC QLQ-C30
timeFrame: Up to 5 Years
measure: Time to role functioning deterioration per EORTC QLQ-C30
timeFrame: Up to 5 Years
Other outcomes:
Locations:
city: La Jolla
country: United States
facility: UC San Diego
state: California
city: San Francisco
country: United States
facility: UCSF Medical Center at Mission Bay
state: California
city: Santa Monica
country: United States
facility: John Wayne Cancer Institute (JWCI)
state: California
city: Englewood
country: United States
facility: The Melanoma And Skin Cancer Institute
state: Colorado
city: Miami
country: United States
facility: Miami Cancer Institute at Baptist Health, Inc.
state: Florida
city: Orlando
country: United States
facility: Orlando Health
state: Florida
city: Tampa
country: United States
facility: Moffitt Cancer Center
state: Florida
city: Chicago
country: United States
facility: Northwestern University
state: Illinois
city: Boston
country: United States
facility: Massachusetts General Hospital
state: Massachusetts
city: Boston
country: United States
facility: Dana-Farber Cancer Institute
state: Massachusetts
city: Detroit
country: United States
facility: Karmanos Cancer Institute
state: Michigan
city: New Brunswick
country: United States
facility: Rutgers Cancer Institute of New Jersey
state: New Jersey
city: New York
country: United States
facility: Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
state: New York
city: New York
country: United States
facility: Columbia University
state: New York
city: Rochester
country: United States
facility: University of Rochester
state: New York
city: Chapel Hill
country: United States
facility: Lineberger Comprehensive Cancer Center
state: North Carolina
city: Durham
country: United States
facility: Duke Cancer Institute, University Hospital
state: North Carolina
city: Cleveland
country: United States
facility: University Hospitals Cleveland Medical Center
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic Foundation
state: Ohio
city: Columbus
country: United States
facility: The Ohio State University James Comprehensive Cancer Center
state: Ohio
city: Easton
country: United States
facility: St Lukes University Health Network
state: Pennsylvania
city: Pittsburgh
country: United States
facility: University Of Pittsburgh
state: Pennsylvania
city: Knoxville
country: United States
facility: University of Tennessee Medical Center
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology - Centennial Clinic Location
state: Tennessee
city: Nashville
country: United States
facility: Verdi Oncology
state: Tennessee
city: Dallas
country: United States
facility: UT Southwestern Medical Center
state: Texas
city: Murray
country: United States
facility: Intermountain Medical Center
state: Utah
city: Charlottesville
country: United States
facility: University of Virginia Medical Center
state: Virginia
city: Caba
country: Argentina
facility: Fundacion Centro de Investigaciones para la Transformacion (CENIT)
state: Buenos Aires
city: Pergamino
country: Argentina
facility: Centro de Investigacion Pergamino
state: Buenos Aires
city: Viedma
country: Argentina
facility: Clinica Viedma S.A.
state: Rio Negro
city: Rosario
country: Argentina
facility: Instituto de Oncologia de Rosario
state: Santa Fe
city: San Miguel de Tucuman
country: Argentina
facility: Centro Medico San Roque
state: Tucuman
city: Caba
country: Argentina
facility: DIABAID - Instituto de Asistencia Integral en Diabetes
city: Blacktown
country: Australia
facility: Blacktown Cancer and Haematology Centre - Blacktown Hospital
state: New South Wales
city: Lismore
country: Australia
facility: Lismore Base Hospital
state: New South Wales
city: Liverpool
country: Australia
facility: Liverpool Hospital - Cancer Therapy Centre
state: New South Wales
city: Wollstonecraft
country: Australia
facility: Melanoma Institute of Australia
state: New South Wales
city: Bedford Park
country: Australia
facility: Flinders Medical Centre
state: South Australia
city: North Adelaide
country: Australia
facility: Calvary North Adelaide Hospital
state: South Australia
city: Box Hill
country: Australia
facility: Eastern Health
state: Victoria
city: Geelong
country: Australia
facility: Andrew Love Cancer Centre
state: Victoria
city: Melbourne
country: Australia
facility: Alfred Hospital
state: Victoria
city: Nedlands
country: Australia
facility: One Clinical Research at Hollywood Private Hospital
state: Western Australia
city: Sint-Niklaas
country: Belgium
facility: Vitaz campus Sint-Niklaas Moerland
state: Oost-Vlaanderen
city: Kortrijk
country: Belgium
facility: AZ Groeninge
state: West-Vlaanderen
city: Bruxelles
country: Belgium
facility: Cliniques Universitaires Saint-Luc
city: Belo Horizonte
country: Brazil
facility: Hospital das Clinicas da Universidade Federal de Minas Gerais
state: Minas Gerais
city: Curitiba
country: Brazil
facility: Liga Paranaense de Combate ao Cancer - Hospital Erasto Gaertner
state: Parana
city: Santo Cristo
country: Brazil
facility: INCA Instituto Nacional de Cancer
state: Rio De Janeiro
city: Ijui
country: Brazil
facility: Oncosite Centro De Pesquisa Em Oncologia
state: Rio Grande Do Sul
city: Passo Fundo
country: Brazil
facility: Instituto do Cancer em Hospital Sao Vicente de Paulo
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Moinhos de vento
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Centro de Pesquisa em Oncologia PUCRS
state: Rio Grande Do Sul
city: Itajai
country: Brazil
facility: Catarina Pesquisa Clinica
state: Santa Catarina
city: Joinville
country: Brazil
facility: Instituto Joinvilense de Hematologia e Oncologia
state: Santa Catarina
city: Lages
country: Brazil
facility: Animi Unidade de Tratamento Oncologico
state: Santa Catarina
city: Barretos
country: Brazil
facility: Fundacao Pio XII - Hospital de Amor
state: Sao Paulo
city: Sao Jose do Rio Preto
country: Brazil
facility: Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto - Hospital de Base
state: Sao Paulo
city: Sorocaba
country: Brazil
facility: Unimed Sorocaba
state: Sao Paulo
city: Rio de Janeiro
country: Brazil
facility: Instituto COI
city: Sao Paulo
country: Brazil
facility: Hemomed
city: Sao Paulo
country: Brazil
facility: Hospital Sirio Libanes
city: Sao Paulo
country: Brazil
facility: Sao Camilo Oncologia
city: Fredericton
country: Canada
facility: Dr. Everett Chalmers Hospital
state: New Brunswick
city: Barrie
country: Canada
facility: Royal Victoria Regional Health Centre
state: Ontario
city: Toronto
country: Canada
facility: Sunnybrook Health Sciences Centre
state: Ontario
city: Toronto
country: Canada
facility: Princess Margaret Cancer Centre
state: Ontario
city: Santiago
country: Chile
facility: Clinica UC San Carlos de Apoquindo
state: Region Metropolitana
city: Santiago
country: Chile
facility: Centro Oncologia de Precision Universidad Mayor
state: Region Metropolitana
city: Vina del Mar
country: Chile
facility: Oncocentro APYS
state: Valparaiso
city: Brno
country: Czechia
facility: Masaryk Memorial Cancer Institute
state: Brno Mesto
city: Hradec Kralove
country: Czechia
facility: University Hospital Hradec Kralove
state: North Central Czech Republic
city: Ostrava
country: Czechia
facility: University Hospital Ostrava
city: Dijon
country: France
facility: Centre Georges Francois Leclerc
state: Bourgogne
city: Dijon
country: France
facility: CHU-Dijon
state: Burgundy
city: Besancon
country: France
facility: Besancon Regional University Hospital Center
state: Doubs
city: Bordeaux
country: France
facility: Chu De Bordeaux
state: Gironde
city: Toulouse
country: France
facility: Institut Claudius Regaud, IUCT-Oncopole
state: Haute-Garonne
city: Lille
country: France
facility: CHU de Lille
state: Hauts-de-France
city: Montpellier Cedex 5
country: France
facility: Service de Dermatologie CHU Saint Eloi
state: Herault
city: Bobigny
country: France
facility: Hopital Avicenne
state: Ile De France
city: Creteil
country: France
facility: Hospital Henri Mondor
state: Ile De France
city: Paris
country: France
facility: Saint Louis Hospital
state: Ile De France
city: La Tronche
country: France
facility: Centre Hospitalier Universitaire Grenoble Alpes
state: Isere
city: Caen
country: France
facility: Centre Francois Baclesse (CFB)
state: Normandy
city: Le Mans
country: France
facility: Centre Hospitalier Le Mans
state: Pays De La Loire
city: Nantes
country: France
facility: Nantes University Hospital
state: Pays De La Loire
city: Amiens
country: France
facility: CHU Amiens-Picardie
state: Picardie
city: Avignon
country: France
facility: Sainte Catherine Institut du Cancer Avignon Provence
city: Boulogne Billancourt
country: France
facility: N_Hôpital Ambroise-Paré
city: Clermont Ferrand
country: France
facility: CHU Estaing
city: Nice
country: France
facility: Centre Hospitalier Universitaire De Nice Hopital De L Archet
city: Valence
country: France
facility: Centre Hospitalier de Valence
city: Villejuif
country: France
facility: Institut Gustave Roussy
city: Tbilisi
country: Georgia
facility: Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic
state: Caucasus
city: Batumi
country: Georgia
facility: Cancer Center of Adjara
city: Tbilisi
country: Georgia
facility: Acad.Fridon Todua Medical Center- Research Institute of Clinical Medicine
city: Tbilisi
country: Georgia
facility: Israeli Georgian Medical Research Clinic Helsicore
city: Tbilisi
country: Georgia
facility: LTD New Hospitals
city: Tbilisi
country: Georgia
facility: JSC K. Eristavi National Center of Experimental and Clinical Surgery
city: Tbilisi
country: Georgia
facility: TIM - Tbilisi Institute of Medicine
city: Mannheim
country: Germany
facility: University Medical Center Mannheim
state: Baden Wurttemberg
city: Tuebingen
country: Germany
facility: University of Tuebingen
state: Baden Wurttemberg
city: Augsburg
country: Germany
facility: University Hospital Augsburg
state: Bavaria
city: Erlangen
country: Germany
facility: Dermatology Erlangen
state: Bavaria
city: Regensburg
country: Germany
facility: University Hospital of Regensburg
state: Bavaria
city: Munich
country: Germany
facility: LMU Klinikum
state: Bayern
city: Darmstadt
country: Germany
facility: Klinikum Darmstadt GmbH
state: Hessen
city: Frankfurt
country: Germany
facility: University Clinic Frankfurt
state: Hessen
city: Gottingen
country: Germany
facility: University Medical Center Goettingen
state: Lower Saxony
city: Schwerin
country: Germany
facility: Helios Kliniken Schwerin
state: Mecklenburg / Vorpommern
city: Munster
country: Germany
facility: University Hospital Muenster
state: North Rhine Westphalia
city: Essen
country: Germany
facility: Universitatsklinikum Essen
state: North Rhine-Westphalia
city: Muenster
country: Germany
facility: Fachklinik Hornheide
state: North Rhine-Westphalia
city: Bochum
country: Germany
facility: Ruhr University Bochum
state: Northrhine Westphalia
city: Ludwigshafen
country: Germany
facility: Hautklinik
state: Rheinland-Pfalz
city: Quedlinburg
country: Germany
facility: Skin Cancer Center Harz
state: Saxony-Anhalt
city: Dresden
country: Germany
facility: University Hospital Dresden
state: Saxony
city: Kiel
country: Germany
facility: University Hospital of Universitatsklinikum Schleswig Holstein (UKSH) Campus Kiel
state: Schleswig Holstein
city: Luebeck
country: Germany
facility: Universitatsklinikum Schleswig Holstein Campus Luebeck
state: Schleswig Holstein
city: Erfurt
country: Germany
facility: Helios Klinikum Erfurt
state: Thuringia
city: Berlin
country: Germany
facility: Charite Universitaetsmedizin Berlin
city: Bremen
country: Germany
facility: Klinikum Bremen Ost
city: Athens
country: Greece
facility: National and Kapodistrian University of Athens
state: Attica
city: Neo Faliro
country: Greece
facility: Metropolitan Hospital
state: Attica
city: Thessaloniki
country: Greece
facility: Ongology Theageneio Thessaloniki
city: Thessaloniki
country: Greece
facility: BioClinic Thessaloniki
city: Thessaloniki
country: Greece
facility: Interbalkan Medical Center
city: Galway
country: Ireland
facility: Galway University Hospital
state: Connacht
city: Cork
country: Ireland
facility: Cork University Hospital
city: Dublin
country: Ireland
facility: Beaumont Hospital
city: Dublin
country: Ireland
facility: St Vincents University Hospital
city: Afula
country: Israel
facility: Haemek Medical Center
state: Northern District
city: Jerusalem
country: Israel
facility: Hadassah Medical Organization
city: Tel Hashomer
country: Israel
facility: Sheba Medical Center
city: Ancona
country: Italy
facility: Clinica Oncologica, AOU Riuniti Ancona
state: An
city: Naples
country: Italy
facility: U.O.C. Oncologia Medica ed Ematologia (U.O.C Medical Oncology and Hematology)
state: Campania
city: Meldola
country: Italy
facility: Istituto Romagnolo per lo Studio dei Tumori (IRST)
state: Forli Cesena
city: Milan
country: Italy
facility: Istituto Clinico Humanitas
state: Lombardy
city: Bari
country: Italy
facility: Istituto dei Tumori
city: Cuneo
country: Italy
facility: Azienda Ospedaliera Santa Croce i Carle
city: Milano
country: Italy
facility: Istituto Europeo di Oncologia
city: Naples
country: Italy
facility: Instituto Nazionale Tumori Fondazione Giovanni Pascale
city: Perugia
country: Italy
facility: University of Perugia
city: Rome
country: Italy
facility: Fondazione Policlinico Universitrio a. Gemelli - IRCCS
city: Rome
country: Italy
facility: Campus Bio-Medico di Roma
city: Rome
country: Italy
facility: Istituto Dermopatico dell'Immacolata
city: Trento
country: Italy
facility: Santa Chiara Hospital
city: Udine
country: Italy
facility: Azienda Sanitaria Universitaria del Friuli Centrale
city: Leon
country: Mexico
facility: Preparaciones Oncologica SC
state: Guanajuato
city: Guadalajara
country: Mexico
facility: Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde
state: Jalisco
city: Guadalajara
country: Mexico
facility: Pan American Clinical Research
state: Jalisco
city: Monterrey
country: Mexico
facility: iCan Oncology
state: Nuevo Leon
city: Culiacan
country: Mexico
facility: Neurociencias Estudios Clinicos SC
state: Sinaloa
city: Merida
country: Mexico
facility: Centro De Atencion E Investigacion Clinica En Oncologia SCP
state: Yucatan
city: Veracruz
country: Mexico
facility: Faicic Centro de Investigacion Clinica de Veracruz
city: Siedlce
country: Poland
facility: Mazowiecki Szpital Wojewodzki, Siedleckie Centrum Onkologii
state: Mazxowieckie
city: Gdansk
country: Poland
facility: UCK
state: Pomerania
city: Gdansk
country: Poland
facility: Copernicus Podmiot Leczniczy Sp. z o.o.Wojewodzie Centrum Onkologii
state: Pomorskie
city: Slupsk
country: Poland
facility: Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Słupsku Sp. z o.o.
state: Pomorskie
city: Poznan
country: Poland
facility: Poznan University of Meidcla Science
state: Wielkopolska
city: Bucharest
country: Romania
facility: Institute of Oncology Bucharest
state: Bucuresti
city: Floresti
country: Romania
facility: Radiotherapy Center Cluj
state: Cluj County
city: Cluj-Napoca
country: Romania
facility: Cardiomed
state: Cluj
city: Cluj-Napoca
country: Romania
facility: Institute of Oncology Prof. Dr Ion Chirircuta
state: Cluj
city: Craiova
country: Romania
facility: Sfantul Nectarie Oncology Center
state: Dolj
city: Timisoara
country: Romania
facility: Oncocenter Oncologie Clinica S.R.L
state: Timis
city: Timisoara
country: Romania
facility: Oncomed
state: Timis
city: Iasi
country: Romania
facility: Centrul De Oncologie Euroclinic
city: Johannesburg
country: South Africa
facility: The Medical Oncology Centre of Rosebank
state: Gauteng
city: Pretoria
country: South Africa
facility: Wilgers Oncology Centre
state: Gauteng
city: Cape Town
country: South Africa
facility: Groote Schuur Hospital
state: Western Cape
city: Kraaifontein
country: South Africa
facility: Cape Town Oncology Trials
state: Western Cape
city: Oviedo
country: Spain
facility: Hospital Universitario Central De Asturias
state: Asturias
city: Badalona
country: Spain
facility: H. Germans Trias i Pujol, ICO-Badalona
state: Barcelona
city: Santander
country: Spain
facility: Hospital Universitario Marques de Valdecilla
state: Cantabria
city: Barcelona
country: Spain
facility: Instituto Oncologico Dr Rosell Hospital Universitari Quiron Dexeus Location
state: Catalunya
city: Barcelona
country: Spain
facility: Hospital Vall d'Hebron
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona
city: Barcelona
country: Spain
facility: Catalan Institute of Oncology (ICO) Hospitalet
city: Granada
country: Spain
facility: Hospital Universitario Virgen de las Nieves
city: Lugo
country: Spain
facility: Hospital Universitario Lucus Augusti
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Maranon
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre Universidad Complutense de Madrid UCM
city: Madrid
country: Spain
facility: Hospital Universitario La Pa<
city: Madrid
country: Spain
facility: Centro Integral Oncologico HM Clara Campal
city: Seville
country: Spain
facility: Hospital Universitario Virgen Macarena
city: Valencia
country: Spain
facility: Instituto Valenciano de Oncologia
city: Valencia
country: Spain
facility: Incliva - Instituto de Investigacion Sanitaria
city: Yuregir
country: Turkey
facility: Baskent University
state: Adana
city: Sur
country: Turkey
facility: Dicle University - Medical Faculty Campus
state: Diyarbakir
city: İzmit
country: Turkey
facility: Kocaeli University
state: Kocaeli
city: Gaziantep
country: Turkey
facility: Gaziantep Medicalpoint Hospital
state: Sehitkamil
city: Ankara
country: Turkey
facility: Gulhane Research And Training Hospital
city: Ankara
country: Turkey
facility: Ozel Liv Hospital
city: Ankara
country: Turkey
facility: Sbu Doctor Abdurrahman Yurtaslan Ankara Onkoloji Suam
city: Ankara
country: Turkey
facility: Memorial Ankara Hospital
city: Edirne
country: Turkey
facility: Trakya University
city: Istanbul
country: Turkey
facility: Istanbul University Cerrahpasa at Cerrahpasa Medical Faculty
city: Istanbul
country: Turkey
facility: Istanbul Medeniyet University - Prof Dr Suleyman Yalcin Sehir Hospital
city: Exeter
country: United Kingdom
facility: Royal Devon and Exeter Hospital NHS Trust
state: Devon
city: Edinburgh
country: United Kingdom
facility: Edinburgh Cancer Centre
state: Lothian
city: Bristol
country: United Kingdom
facility: Bristol Haematology And Oncology Centre (BHOC) - Bristol Cancer Institute
state: Somerset
city: Sutton
country: United Kingdom
facility: The Royal Marsden NHS Foundation Trust
state: Surrey
city: Coventry
country: United Kingdom
facility: University Hospital Coventry and Warwickshire Nhs Trust
state: West Midlands
city: London
country: United Kingdom
facility: Saint Bartholomew's Hospital
city: London
country: United Kingdom
facility: University College London Hospitals
city: Manchester
country: United Kingdom
facility: The Christie
city: Taunton
country: United Kingdom
facility: Taunton and Somerset NHS Foundation Trust
Study officials:
affiliation: Regeneron Pharmaceuticals
name: Clinical Trial Management
role: STUDY_DIRECTOR
References: