Clinical trial NCT03464994: Ophthalmological Abnormalities in Hereditary Ichthyosis (ICHTYO-KERATO)
Official title: Prevalence of Ophthalmological Abnormalities in Children and Adults Suffering From Hereditary Ichthyosis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Ichthyosis
Keywords: Hereditary ichthyosis
keratoconus
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
Collaborators: name: Association for the development of research in Dermatology
First posted: 2018-03-14
Enrollment: 152
Sex: ALL
Minimum age (years): 6
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Presence/absence of subclinical keratoconus with corneal topographic abnormalities (skewed radial axes for forme fruste keratoconus, and inferior steepening for keratoconus suspect) on axial specular topography (TMS-4 Tomey), and elevation topographies: Pentacam (Oculus) and Orbscan (Bausch \& Lomb).

Detailed description: Background: Hereditary ichthyosis are rare genetic diseases characterized by an abnormal epithelial keratinization due to mutations in gene involved in skin barrier. Patients present with scales on the whole body. Recent classification basically distinguishes syndromic from non-syndromic forms. Ichthyoses are severe diseases with significant impact on quality of life, due to troublesome symptoms (pruritus, pain), lack of effective therapy and complications such as ophthalmological anomalies. Among ophthalmological abnormalities, some are well known, such as eyelid abnormalities, including ectropion, and sicca syndrome. Conversely, corneal abnormalities such as keratoconus are not or very partially described in ichthyosis. The keratoconus is characterized by a corneal thickening and bulging with progressive loss of vision that may require a corneal transplantation. Its prevalence is 0.05% in its symptomatic presentation but may reach 10% when considering subclinical keratoconus diagnosed on basis of corneal topographies. These forme fruste keratoconus or keratoconus suspect may remain subclinical or instead progress to severe keratoconus. Corneal collagen crosslinking has been shown to strengthen the cornea in order to halt progressive keratoconus, justifying the need for early screening. Keratoconus is a complex condition of multifactorial etiology. With regards to the pathophysiology of the keratoconus, some hypotheses incriminate the corneal epithelial differentiation that is similar to the epidermal differentiation altered in ichthyosis. This link between both dermatological and ophthalmological abnormalities is supported by clinical experience. It's was observed that ichthyosis patients have frequently a subclinical keratoconus. In clinical practice, ophthalmological abnormalities are not commonly investigated in ichthyosis patients and there are no data on prevalence in the literature. Furthermore, there are no guidelines on screening or therapy of ophthalmological abnormities in ichthyosis.

The purpose of this project is to demonstrate that the prevalence of subclinical keratoconus (including forme fruste keratoconus and keratoconus suspect) is higher in ichthyosis compared to healthy controls.

Descriptive analysis of the studied population for primary outcome: The proportion of patients with subclinical keratoconus (including form fruste keratoconus and keratoconus suspect) will be described in each study-group and compared between study-groups using Mac Nemar Test.

Eligibility criteria: Inclusion Criteria:

For ichthyosis population:

* Hereditary ichthyosis, whatever form or ongoing therapy.
* Parental permission for minors

For controls:

* Patients who consult an ophthalmologist for refractive surgery screening or systematic eye examination
* Parental permission for minors

Exclusion Criteria:

For both populations:

* Patient who cannot stay seated
* Wearing contact lens within the last 7 days
* No social security
* Past medical history of corneal or eye surgery or eye condition (glaucoma, uveitis, keratoconus, retinal diseases)
* Impossibility to fill the questionnaires

Primary outcomes:
measure: Presence/absence of subclinical keratoconus
timeFrame: 10 mn
Secondary outcomes:
measure: Presence/absence of symptomatic keratoconus with irregular topographic maps
timeFrame: 10 mn
measure: Presence/absence of an abnormality of corneal transparency
timeFrame: 10 mn
measure: Presence/absence of sicca syndrome
timeFrame: 10 mn
measure: Evaluation of quality of vision
timeFrame: 10 mn
measure: Quality of life for adults
timeFrame: 10 mn
Other outcomes:
Locations:
city: Toulouse
country: France
facility: University Hospital of Toulouse
Study officials:
affiliation: University Hospital, Toulouse
name: Juliette MAZEREEUW, MD
role: PRINCIPAL_INVESTIGATOR
References: