Clinical trial NCT06105866: Relationship of Preoperative Fasting With Tricuspid Annular Plane Systolic Excursion
Official title: Relationship of Preoperative Fasting With Tricuspid Annular Plane Systolic Excursion (TAPSE)
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: The Relationship Between TAPSE Value and Volume
Keywords: Tricuspid Annular Plane Systolic Excursion
Preoperative Fasting
Right ventricular functions
Lead sponsor: Aydin Adnan Menderes University
Sponsor class: OTHER
First posted: 2023-10-30
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients scheduled for surgery who have applied to Adnan Menderes University Hospital

Brief summary: The aim of our study is to try to establish a relationship between preoperative fasting-related volume changes and tricuspid annular plane systolic excursion (TAPSE), and to determine whether there are changes in right ventricular functions due to preoperative fasting.

Detailed description: TAPSE (Tricuspid Annular Plane Systolic Excursion) is a parameter that easily measures apex-base shortening and provides specific information about global right ventricular (RV) function. It is less dependent on optimal image quality and serves as an easily measurable criterion compared to other RV function measurements. In this study, one day before the operation, transthoracic echocardiography (TTE) will be conducted on fasting patients, and if the preoperative fasting duration is appropriate on the day of the surgery, TTE measurements will be repeated and recorded. The study aims to evaluate the relationship between TAPSE and volume and determine whether there are any changes in right ventricular functions due to preoperative fasting.

Eligibility criteria: Inclusion Criteria:

* ASA 1-2-3
* The patient must be between 18 and 75 years old.
* Perioperative hydration has not been administered.
* Preoperative sedatives have not been given.
* There should be no known heart disease.

Exclusion Criteria:

* The patient being pregnant
* Post-cardiac surgery
* Severe pulmonary hypertension
* Severe valve disease
* Hypertrophic or dilated cardiomyopathy
* Presence of acute myocardial infarction
* Non-sinus rhythm

Primary outcomes:
measure: The TAPSE value is related to volume
timeFrame: Patients who apply to our hospital for surgery within 6 months will be included in our study. Preoperative TAPSE measurements will be taken from the patients twice, first during admission and immediately before the operation
Secondary outcomes:
Other outcomes:
Locations:
city: Aydın
country: Turkey
facility: Sevil Gulasti
state: Zafer
Study officials:
References:
citation: Lee S, Kamdar F, Madlon-Kay R, Boyle A, Colvin-Adams M, Pritzker M, John R. Effects of the HeartMate II continuous-flow left ventricular assist device on right ventricular function. J Heart Lung Transplant. 2010 Feb;29(2):209-15. doi: 10.1016/j.healun.2009.11.599.
citation: Gullupinar B, Saglam C, Koran S, Turhan A, Unluer EE. The role of mitral annular plane systolic excursion in prediction of acute blood loss in healthy voluntary blood donors. J Ultrason. 2022 Feb 8;22(88):e33-e38. doi: 10.15557/JoU.2022.0006. eCollection 2022 Mar.
citation: Zhang H, Wang X, Chen X, Zhang Q, Liu D. Tricuspid annular plane systolic excursion and central venous pressure in mechanically ventilated critically ill patients. Cardiovasc Ultrasound. 2018 Aug 7;16(1):11. doi: 10.1186/s12947-018-0130-2.
citation: Newman K, Wilson R, Roberts JM, Mayo JR, Mohamed Ali AA, Brunner N, Sedlic A. Tricuspid annular plane systolic excursion for the evaluation of right ventricular function in functional cardiac CT compared to MRI. Clin Radiol. 2021 Aug;76(8):628.e1-628.e7. doi: 10.1016/j.crad.2021.02.018. Epub 2021 Apr 18.