Clinical trial NCT04445376: Effect of Physical Therapy Exercises on Cardiorespiratory Fitness Level in COVID19 Patients After Recovery.
Official title: Effect of Aerobic Exercises on Cardio-respiratory Fitness and Quality of Life in Recovered COVID 19 Recovered Patients.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Covid19
Keywords: Cardiorespiratory fitness
Lead sponsor: Government College University Faisalabad
Sponsor class: OTHER
First posted: 2020-06-24
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In some patients, lung function declined by about 20 to 30% after recovery. Computer tomography of COVID-19 patients revealed a ground glass opacity in both lungs. We will measure the Cardiorespiratory fitness according to American College of Sports medicine guidline and provide physiotherapy exercise to the patients to measure the improvement.

Detailed description: In December 2019, the first reports emerged of a novel severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) in Wuhan, China. The virus, which causes atypical pneumonia progressing to acute lung injury and acute respiratory distress syndrome (ARDS) in some individuals, was named COVID-19. The burden of fibrotic lung disease following SARS-CoV-2 infection is likely to be high; therefore, given the scale of the pandemic, the global burden of fibrotic lung disease will probably increase considerably. The aim of this study is to check the cardiorespiratory fitness level and the effect of Physical therapy intervention to improve the Cardiorespiratory fitness level in patients recovered from COVID-19. Quality of life has also been affected due to COVID19 due to decreased Cardiorespiratory fitness level, and this study also aims to improve the quality of life of people recovered from COVID19.

Eligibility criteria: Inclusion Criteria:

* Recovered from COVID 19 disease (PCR report).
* Sub-normal performance as compared to normative data.
* Do not have any Respiratory Problem.
* Consent to participate in the study.
* Able to understand and perform the exercise.
* Age from 18 to 75.
* Dyspnea due to COVID19.
* Modified Borg Dyspnea Scale score at least 2 but less than 7.

Exclusion Criteria:

* Not suffered from COVID 19.
* Respiratory Problem.
* Resting Blood Pressure greater than 160/100 instead of taking medicine
* Greater than 1-month post COVID19 Recovery.
* Cardiorespiratory comorbidities which limit participation in exercise.
* Any Musculoskeletal problem which limit participation in Training.
* Other cardiovascular morbidity which would limit exercise tolerance (heart failure, abnormal blood pressure responses or ST-segment depression \> 2mm, symptomatic aortic stenosis, complex arrhythmias).
* Unstable angina
* Orthostatic blood pressure decrease of \>20 mmHg with symptoms
* Hypertropic cardiomyopathy

Primary outcomes:
measure: 6 minute walk test
timeFrame: 5 weeks
measure: Modified Borg Dyspnea Scale
timeFrame: 5 weeks
Secondary outcomes:
measure: SF-36 QUESTIONNAIRE
timeFrame: 5 weeks
Other outcomes:
Locations:
city: Faisalābad
country: Pakistan
facility: Bin Inam Rehabilitation Center.
state: Punjab
Study officials:
affiliation: Government College University
name: Ishtiaq Ahmed, DPT
role: PRINCIPAL_INVESTIGATOR
References:
citation: George PM, Wells AU, Jenkins RG. Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy. Lancet Respir Med. 2020 Aug;8(8):807-815. doi: 10.1016/S2213-2600(20)30225-3. Epub 2020 May 15.
citation: Belli S, Balbi B, Prince I, Cattaneo D, Masocco F, Zaccaria S, Bertalli L, Cattini F, Lomazzo A, Dal Negro F, Giardini M, Franssen FME, Janssen DJA, Spruit MA. Low physical functioning and impaired performance of activities of daily life in COVID-19 patients who survived hospitalisation. Eur Respir J. 2020 Oct 15;56(4):2002096. doi: 10.1183/13993003.02096-2020. Print 2020 Oct.