Clinical trial NCT06121791: Abdominal Skeletal Muscle Compartments in Turkish Children
Official title: Establishment Reference Values for Abdominal Skeletal Muscle Compartments in Turkish Children
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Child Development
Sarcopenia
Keywords: children
Abdominal Skeletal Muscle
Sarcopenia
Lead sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2023-11-08
Enrollment: 2168
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy Turkish children

Brief summary: The aim of this study was to establish reference values for three compartments of the abdominal skeletal muscle area (psoas muscle area, paraspinal muscle area, and total skeletal muscle area) obtained from cross-sectional Computed tomography images in Turkish Children

Detailed description: The aim in this study is to determine reference values for Turkish children by evaluating the abdominal region skeletal muscle area (psoas muscle, paraspinal muscles and total skeletal muscle in the section) obtained from cross-sectional CT images.

Material Method of the Research The study was planned as a retrospective study. Patients under 18 years of age who are admitted to Istanbul Province Bağcılar Training and Research Hospital with acute abdominal pain or acute trauma between May 5, 2017 and May 5, 2023 and who underwent abdominal computed tomography (CT) imaging on this date of application will be scanned through the hospital information management system. Past diagnoses of these patients will be questioned and those with chronic diseases will be excluded from the study.

CT images of the patients will be retrieved from the PACS database. From the sections taken at the L3-L4, L4-L5 levels, the cross-sectional area of the psoas muscle, paraspinal muscles and the total skeletal muscles in that section will be measured using the hospital's SYNAPS system. The results will be recorded in cm2.

Eligibility criteria: Inclusion Criteria:

* No chronic disease
* Being under 18 years of age
* Being Turkish
* Determining that an abdominal CT was performed in the hospital records

Exclusion Criteria:

* Patients with malignancy or known chronic disease
* Patients with mental health problems

Primary outcomes:
measure: L3-L4 LEVEL: Psoas muscle area
timeFrame: 1 interview day
measure: L3-L4 LEVEL:Paraspinal muscle area
timeFrame: 1 interview day
measure: L3-L4 LEVEL: Abdominal muscle area,
timeFrame: 1 interview day
measure: L4-L5 LEVEL: Psoas muscle area
timeFrame: 1 interview day
measure: L4-L5 LEVEL: Paraspinal muscle area
timeFrame: 1 interview day
measure: L4-L5 LEVEL: Abdominal muscle area,
timeFrame: 1 interview day
Secondary outcomes:
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Istanbul Physical Medicine Rehabilitation Training & Research Hospital
Study officials:
affiliation: Istanbul Physical Medicine Rehabilitation Training and Research Hospital
name: TUGBA AYDIN
role: STUDY_CHAIR
affiliation: ISTANBUL BAĞCILAR TRAINING AND RESEARCH HOSPITAL RADIOLOGY UNIT
name: EDA CINGOZ
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kudo W, Terui K, Hattori S, Takenouchi A, Komatsu S, Oita S, Sato Y, Hishiki T. Establishment and validation of reference values for abdominal skeletal muscle compartments in children. Clin Nutr. 2023 May;42(5):653-660. doi: 10.1016/j.clnu.2023.02.022. Epub 2023 Mar 2.
citation: Harbaugh CM, Zhang P, Henderson B, Derstine BA, Holcombe SA, Wang SC, Kohoyda-Inglis C, Ehrlich PF. Personalized medicine: Enhancing our understanding of pediatric growth with analytic morphomics. J Pediatr Surg. 2017 May;52(5):837-842. doi: 10.1016/j.jpedsurg.2017.01.030. Epub 2017 Jan 29.
citation: Metzger GA, Sebastiao YV, Carsel AC, Nishimura L, Fisher JG, Deans KJ, Minneci PC. Establishing Reference Values for Lean Muscle Mass in the Pediatric Patient. J Pediatr Gastroenterol Nutr. 2021 Feb 1;72(2):316-323. doi: 10.1097/MPG.0000000000002958.
citation: Lurz E, Patel H, Lebovic G, Quammie C, Woolfson JP, Perez M, Ricciuto A, Wales PW, Kamath BM, Chavhan GB, Juni P, Ng VL. Paediatric reference values for total psoas muscle area. J Cachexia Sarcopenia Muscle. 2020 Apr;11(2):405-414. doi: 10.1002/jcsm.12514. Epub 2020 Jan 9.