Clinical trial NCT00830843: Inhalatorial Sedation in Patient With Subarachnoid Hemorrhage (SAH) Versus Conventional Intravenous Sedation
Official title: Inhalatorial Sedation in Patient With SAH Versus Conventional Intravenous Sedation (GAS-SAH)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Stroke
Subarachnoid Hemorrhage
Keywords: SAH
sedation
anesthesia
Lead sponsor: Azienda Ospedaliera San Gerardo di Monza
Sponsor class: OTHER
First posted: 2009-01-28
Enrollment: 13
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Recent study has shown that inhalatory sedation is a practicable, effective and not risky method in Intensive Care Unit. Sevoflurane effect on cerebral system have been described in previous studies: it causes an increasing of cerebral blood flow and a decrease of oxygen cerebral consumption. Clinical strategy for Subarachnoid Hemorrhage is orientated to increase cerebral blood flow to limit vasospasm phenomena after SAH. Scope of this study is to evaluate the Cerebral Blood Flow variation associated to Isoflurane sedation versus conventional sedation with propofol .


Eligibility criteria: Inclusion Criteria:

* diagnosis of aSAH
* indication to DVE positioning
* clinical indication to sedation and assisted ventilation
* indication to ICP and CBF monitoring
* age \> 18

Exclusion Criteria:

* documented cranial hypertension (ICP\>18) not controller by liquor drainage
* age \< 18.

Primary outcomes:
measure: Cerebral Blood Flow
timeFrame: after 2 hours of drug administration
Secondary outcomes:
Other outcomes:
Locations:
city: Monza
country: Italy
facility: Azienda Ospedaliera San Gerardo
Study officials:
affiliation: Azienda Ospedaliera San Gerardo Monza
name: Federico Villa, MD
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Villa F, Iacca C, Molinari AF, Giussani C, Aletti G, Pesenti A, Citerio G. Inhalation versus endovenous sedation in subarachnoid hemorrhage patients: effects on regional cerebral blood flow. Crit Care Med. 2012 Oct;40(10):2797-804. doi: 10.1097/CCM.0b013e31825b8bc6.