Clinical trial NCT03982394: Observational Study of Patients With Moderate to Severe Chronic Plaque Psoriasis
Official title: Multi-Country Prospective ObserVAtionaL, Cohort Study of Patients With Moderate to Severe Chronic PlaqUE Psoriasis (VALUE)
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Plaque Psoriasis
Keywords: Chronic Plaque Psoriasis Risankizumab Biologics Psoriasis Vulgaris
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2019-06-11
Enrollment: 2439
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study will enroll adult subjects with moderate to severe plaque psoriasis.

Brief summary: This study will assess the use of risankizumab in adult patients with moderate to severe chronic plaque psoriasis and compare risankizumab to other commonly used biologics.


Eligibility criteria: Inclusion Criteria:

* Confirmed diagnosis of moderate to severe chronic plaque-type psoriasis diagnosed by a specialist and presence of moderate to severe psoriasis symptoms according to physician's judgement at time of recruitment.
* Participant starting any approved treatment for psoriasis and physician's decision must be reached prior to recruitment in the study.
* Participant willing to continue with study documentation after cessation of therapy.

Exclusion Criteria:

* Unwillingness or inability to comply with study requirements.
* Participation in an interventional clinical trial, concurrently or within the last 30 days. Participation in a post-market observational study (PMOS) or Registry is acceptable.

Primary outcomes:
measure: Percentage of participants who achieved Psoriasis Area and Severity Index (PASI) 90
timeFrame: From Month 4 to 3 years
measure: Time to first treatment change
timeFrame: From Week 0 (Baseline) to first treatment change
Secondary outcomes:
measure: Time to first treatment change rate
timeFrame: At 1 year, 2 year, and 3 year
measure: Percentage of participants who achieved Static Physicians Global Assessment (sPGA) 0/1 or sPGA 0
timeFrame: Monthly for up to 3 years
measure: Percentage of participants who achieved Psoriasis Area and Severity Index (PASI) 75, 90, or 100
timeFrame: Monthly for up to 3 years
measure: Percentage of participants who achieved Absolute PASI<=5, <=3 or <=1
timeFrame: Monthly for up to 3 years
measure: Time to achieve sPGA 0/1 or sPGA 0
timeFrame: Up to 3 years
measure: Time to achieve PASI 75, 90,or 100
timeFrame: Up to 3 years
measure: Percentage of participants who achieve sPGA 0/1 or sPGA 0 at 4 Months and maintained the response status at 1 Year, 2 Years and 3 Years without increasing the dose or shortening the dose interval
timeFrame: At 4 months to 1 year, 2 years, and 3 years
measure: Percentage of participants who achieved PASI 90 or PASI 100 at 4 Months and maintained the response status at 1 Year, 2 Years, and 3 Years without changing the indicated dose or dosing interval
timeFrame: At 4 months and 1 year, 2 years, and 3 years
measure: Change in PASI
timeFrame: From Week 0 to up to 3 years
measure: Change in Body Surface Area (BSA)
timeFrame: From Week 0 to up to 3 years
measure: Change in Dermatology Quality of Life Index (DLQI) Score
timeFrame: From Week 0 to up to 3 years
measure: Percentage of participants who achieve DLQI 0/1
timeFrame: Monthly for up to 3 years
measure: Change in Treatment Satisfaction Questionnaire for Medication (TSQM) score
timeFrame: From Week 0 to up to 3 years
Other outcomes:
Locations:
city: Lomas de Zamora
country: Argentina
facility: Emiliano Baccarini Priv Practice /ID# 218581
state: Buenos Aires
city: Pilar
country: Argentina
facility: Hospital Universitario Austral /ID# 217540
state: Buenos Aires
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Stringa Dermatologia /ID# 218450
state: Ciudad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Stat Research /ID# 217185
state: Ciudad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Buenos Aires Skin /ID# 217657
state: Ciudad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: CEDIC Centro de Investigaciones Clinicas /ID# 217184
state: Ciudad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Instituto de Neumonologia y Dermatologia /ID# 217429
state: Ciudad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Psoriahue Med Interdisciplinar /ID# 217182
state: Ciudad Autonoma De Buenos Aires
city: Buenos Aires
country: Argentina
facility: Professional Skin Care /ID# 218514
city: Caba
country: Argentina
facility: Hospital Italiano /ID# 217000
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Private Office Cristina Echeverria /ID# 222082
city: Kogarah
country: Australia
facility: Premier Specialist /ID# 218158
state: New South Wales
city: Miranda
country: Australia
facility: Kingsway Dermatology & Aesthetics /ID# 217616
state: New South Wales
city: Chermside
country: Australia
facility: Northern Dermatology /ID# 218374
state: Queensland
city: Woolloongabba
country: Australia
facility: Veracity Clinical Research /ID# 217618
state: Queensland
city: Carlton
country: Australia
facility: Skin Health Institute Inc /ID# 217619
state: Victoria
city: Fremantle
country: Australia
facility: Fremantle Dermatology /ID# 217617
state: Western Australia
city: Wels
country: Austria
facility: Klinikum Wels-Grieskirchen GmbH /ID# 216140
state: Oberoesterreich
city: Graz
country: Austria
facility: Medizinische Universitaet Graz /ID# 217702
state: Steiermark
city: Dornbirn
country: Austria
facility: Hautarzt Dr. Lukas Kraus /ID# 216139
state: Vorarlberg
city: Vienna
country: Austria
facility: Klinik Landstrasse /ID# 217684
state: Wien
city: Vienna
country: Austria
facility: Medizin am Hauptbahnhof /ID# 218837
state: Wien
city: Vienna
country: Austria
facility: EZW HAUT Entzuendungszentrum Wien /ID# 215488
state: Wien
city: Vienna
country: Austria
facility: Klinik Hietzing /ID# 217685
state: Wien
city: Vienna
country: Austria
facility: Klinik Donaustadt /ID# 218842
state: Wien
city: Hainfeld
country: Austria
facility: Haut Trattner Dermatologie /ID# 216138
city: Calgary
country: Canada
facility: Beacon Dermatology Inc /ID# 213524
state: Alberta
city: Edmonton
country: Canada
facility: Duplicate_Stratica Medical /ID# 213526
state: Alberta
city: Edmonton
country: Canada
facility: Alberta DermaSurgery Centre /ID# 230114
state: Alberta
city: Vancouver
country: Canada
facility: University of British Columbia - Eye Care Centre, Vancouver General Hospital /ID# 213507
state: British Columbia
city: Brandon
country: Canada
facility: SKIN Clinics /ID# 213082
state: Manitoba
city: Winnipeg
country: Canada
facility: Winnipeg Clinic /ID# 212134
state: Manitoba
city: Fredericton
country: Canada
facility: Dr. Irina Turchin PC Inc. /ID# 212128
state: New Brunswick
city: St. John's
country: Canada
facility: Karma Clinical Trials /ID# 213522
state: Newfoundland and Labrador
city: St. John's
country: Canada
facility: NewLab Clinical Research Inc. /ID# 213521
state: Newfoundland and Labrador
city: St. John's
country: Canada
facility: Dr. Brown-Maher PMC INC. /ID# 212136
state: Newfoundland and Labrador
city: Ajax
country: Canada
facility: CCA Medical Research /ID# 214446
state: Ontario
city: Barrie
country: Canada
facility: SimcoDerm Medical and Surgical Dermatology Center /ID# 213081
state: Ontario
city: Hamilton
country: Canada
facility: LEADER Research /ID# 249701
state: Ontario
city: Hamilton
country: Canada
facility: Lima's Excellence in Allergy and Dermatology Research Inc /ID# 231973
state: Ontario
city: Hamilton
country: Canada
facility: Hamilton Health Sciences Corporation /ID# 214053
state: Ontario
city: Hamilton
country: Canada
facility: Dermatrials Research /ID# 213523
state: Ontario
city: Markham
country: Canada
facility: Lynde Institute for Dermatology /ID# 212124
state: Ontario
city: Mississauga
country: Canada
facility: Al-Mohammedi Medicine Professional Corporation /ID# 215408
state: Ontario
city: Mississauga
country: Canada
facility: DermEdge Research Inc. /ID# 213525
state: Ontario
city: Ottawa
country: Canada
facility: Angela Montgomery Medicine Professional Corporation /ID# 213615
state: Ontario
city: Peterborough
country: Canada
facility: Dr Melinda Gooderham Medicine Professional Corporation /ID# 212133
state: Ontario
city: Stoney Creek
country: Canada
facility: Farheen Mussani Medicine Professional Corporation /ID# 213811
state: Ontario
city: Toronto
country: Canada
facility: North York Research Inc /ID# 213486
state: Ontario
city: Waterloo
country: Canada
facility: Private Practice - Dr. Kim Papp Clinical Research /ID# 212130
state: Ontario
city: Whitby
country: Canada
facility: Dr Maksym Breslavets Medicine Professional Corporation /ID# 213338
state: Ontario
city: Laval
country: Canada
facility: Clinique D /ID# 212126
state: Quebec
city: Quebec City
country: Canada
facility: Centre de Recherche St-Louis /ID# 216325
state: Quebec
city: Medellin
country: Colombia
facility: Clinisalud del sur /ID# 222685
state: Antioquia
city: Medellin
country: Colombia
facility: IPS Universitaria /ID# 241832
state: Antioquia
city: Medellín
country: Colombia
facility: Fundacion hospitalaria San Vicente de Paul /ID# 222680
state: Antioquia
city: Soledad
country: Colombia
facility: Fundacion Hospital Universidad del Norte /ID# 223428
state: Atlantico
city: Bogota
country: Colombia
facility: Sociedad de Cirugía de Bogotá- Hospital de San José /ID# 222683
state: Cundinamarca
city: Bogotá
country: Colombia
facility: Caja de Compensación Familiar Cafam, Sede Centro de Atención En Salud Cafam Flor /ID# 222660
state: Cundinamarca
city: Bogotá
country: Colombia
facility: Centro Dermatológico Federico Lleras Acosta E.S.E /ID# 222686
state: Cundinamarca
city: Zipaquirá
country: Colombia
facility: Healthy Medical Center S.A.S /ID# 231909
state: Cundinamarca
city: Barranqulla
country: Colombia
facility: Ciensalud IPS S.A.S /ID# 244608
city: Ceske Budejovice
country: Czechia
facility: Nemocnice Ceske Budejovice a.s. /ID# 216310
city: Hradec Kralove
country: Czechia
facility: Fakultni nemocnice Hradec Kralove /ID# 222670
city: Olomouc
country: Czechia
facility: Fakultni nemocnice Olomouc /ID# 215901
city: Prague
country: Czechia
facility: Duplicate_Fakultni Nemocnice v Motole /ID# 215484
city: Praha
country: Czechia
facility: Fakultni nemocnice Kralovske Vinohrady /ID# 233184
city: Praha
country: Czechia
facility: Sanatorium profesora Arenbergera /ID# 215489
city: Marseille
country: France
facility: Hopital Saint Joseph /ID# 223149
state: Bouches-du-Rhone
city: Rennes
country: France
facility: CHU de Rennes - PONTCHAILLOU /ID# 218248
state: Bretagne
city: Dijon
country: France
facility: CHU Dijon /ID# 216247
state: Cote-d Or
city: Niort CEDEX
country: France
facility: CH Georges Renon /ID# 216174
state: Deux-Sevres
city: Romans Sur Isere
country: France
facility: Hopitaux Drome Nord /ID# 222586
state: Drome
city: Valence
country: France
facility: CH Valence /ID# 225877
state: Drome
city: Brest
country: France
facility: Hopital de la Cavale Blanche /ID# 216495
state: Finistere
city: Tarbes CEDEX 9
country: France
facility: CH Bigorre - Site de la Gespe /ID# 218563
state: Hautes-Pyrenees
city: La Tronche
country: France
facility: CHU Grenoble - Hopital Michallon /ID# 218437
state: Isere
city: Chalons en Champagne
country: France
facility: Ch Chalons En Champagne /Id# 216668
state: Marne
city: Le Mans CEDEX 9
country: France
facility: Centre Hospitalier du Mans /ID# 225729
state: Sarthe
city: Chambery CEDEX
country: France
facility: Centre Hospitalier Métropole Savoie - Site Hôpital de Chambéry /ID# 217572
state: Savoie
city: Amiens CEDEX 1
country: France
facility: CHU Amiens-Picardie Site Sud /ID# 216170
state: Somme
city: Pontoise
country: France
facility: CH Pontoise - Hopital René Dubos /ID# 216169
state: Val-d Oise
city: Auxerre
country: France
facility: Ch Auxerre /Id# 216175
state: Yonne
city: Aix En Provence Cedex 1
country: France
facility: CH du Pays d'AIX /ID# 216440
city: Angers
country: France
facility: Chu Angers /Id# 216244
city: Boulogne Billancourt
country: France
facility: Hopital Ambroise Pare /ID# 216439
city: Caen
country: France
facility: CHU de CAEN - Hopital de la Cote de Nacre /ID# 216245
city: Cannes
country: France
facility: Cabinet Dermatologie et Esthetique /ID# 229132
city: Chalon Sur Saone
country: France
facility: CH William Morey /ID# 225441
city: Epagny Metz Tessy
country: France
facility: CH Annecy Genevois - Site Annecy /ID# 225786
city: Lorient
country: France
facility: C.H. de Bretagne Sud /ID# 216243
city: Saint-Mandé cedex
country: France
facility: Hôpital d'instruction des armées Bégin /ID# 216167
city: St-Priest-en-Jarez
country: France
facility: Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord /ID# 216663
city: Thionville
country: France
facility: CHR Metz-Thionville - Hopital Bel-Air /ID# 225691
city: Toulon CEDEX 9
country: France
facility: Hôpital d'Instruction des Armées Sainte-Anne /ID# 218888
city: Mannheim
country: Germany
facility: Universitatsklinikum Mannheim /ID# 214569
state: Baden-Wuerttemberg
city: Erlangen
country: Germany
facility: Universitaetsklinikum Erlangen /ID# 213669
state: Bayern
city: Memmingen
country: Germany
facility: Beldio Research GmbH /ID# 213958
state: Bayern
city: Bramsche
country: Germany
facility: Studienzentrum an der Hase GbR Dr. Weyergraf/Dr. Frick/Thomas Heiber /ID# 214466
state: Niedersachsen
city: Mainz
country: Germany
facility: Universitaetsmedizin Mainz /ID# 222025
state: Rheinland-Pfalz
city: Selters
country: Germany
facility: CMS3 Company for Medical Study /ID# 213676
state: Rheinland-Pfalz
city: Merzig
country: Germany
facility: HMS GmbH Zimmer /ID# 225219
state: Saarland
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 213670
state: Schleswig-Holstein
city: Kiel
country: Germany
facility: DermaKiel Allergie und Haut Centrum /ID# 213977
state: Schleswig-Holstein
city: Jena
country: Germany
facility: Universitaetsklinikum Jena /ID# 214259
state: Thueringen
city: Andernach
country: Germany
facility: Bell, Andernach, DE /ID# 214545
city: Augsburg
country: Germany
facility: Praxis Dr. Mihaescu /ID# 213483
city: Bad Kreuznach
country: Germany
facility: Mauer, Bad Kreuznach, DE /ID# 224876
city: Bad Soden am Taunus
country: Germany
facility: Hautmedizin Bad Soden /ID# 213956
city: Bergen
country: Germany
facility: Timmel/Timm/Vorwerk, Bergen /ID# 214552
city: Berlin
country: Germany
facility: Hasert & Hasert, Berlin, DE /ID# 213641
city: Berlin
country: Germany
facility: Hautzentrum Friedrichshain /ID# 213981
city: Berlin
country: Germany
facility: Weihe/Stavermann, Berlin, DE /ID# 214550
city: Berlin
country: Germany
facility: Praxis Dr. med. Alexander Zich /ID# 245751
city: Berlin
country: Germany
facility: Hautarztzentrum Tegel /ID# 214849
city: Bielefeld
country: Germany
facility: Klinikum Rosenhoehe /ID# 215520
city: Blaubeuren
country: Germany
facility: Praxis fuer Innere Medizin/Rheumatologie /ID# 213653
city: Bogen
country: Germany
facility: Praxis T. Schadeck /ID# 213957
city: Borna
country: Germany
facility: Barth, Borna, DE /ID# 213643
city: Bremen
country: Germany
facility: Schwichtenberg, Bremen, DE /ID# 213650
city: Buxtehude
country: Germany
facility: Elbe Klinikum Buxtehude /ID# 213366
city: Darmstadt
country: Germany
facility: Praxis Herbst /ID# 222024
city: Deggendorf
country: Germany
facility: Praxis Dr. Sbornik /ID# 213668
city: Dessau-rosslau
country: Germany
facility: Heidlas, Dessau-Rosslau, DE /ID# 217691
city: Dresden
country: Germany
facility: Richter-Huhn, Dresden, DE /ID# 213659
city: Dueren
country: Germany
facility: Praxis Dr. Korge /ID# 213475
city: Essen
country: Germany
facility: Dres. Cesko u. Körber /ID# 214850
city: Freising
country: Germany
facility: Kurzen, Freising, DE /ID# 214567
city: Gelsenkirchen
country: Germany
facility: Gemeinschaftspraxis Rietkoetter und Jablonka /ID# 213482
city: Gera
country: Germany
facility: Praxis Dr. Lange /ID# 213984
city: Gernsbach
country: Germany
facility: Loth, Gernsbach, DE /ID# 214848
city: Giessen
country: Germany
facility: Gross/Braeu, Giessen, DE /ID# 213367
city: Gießen
country: Germany
facility: Hautarztpraxis Dr. Viehmann /ID# 213675
city: Gladbeck
country: Germany
facility: Brinkmann & Partner, Gladbeck, /ID# 214247
city: Hamburg
country: Germany
facility: Universitaetsklinikum Hamburg-Eppendorf /ID# 222464
city: Hamburg
country: Germany
facility: Dermatologikum Hamburg /ID# 213978
city: Hamburg
country: Germany
facility: Goldbek Medical /ID# 214570
city: Hannover
country: Germany
facility: Praxis Dres. Kaspari /Schenck /ID# 213649
city: Haßfurt
country: Germany
facility: Hautarztpraxis Haßberge /ID# 213644
city: Heilbad Heiligenstadt
country: Germany
facility: Gemeinschaftspraxis Dres. Anika Hünermund/Mario Pawlak /ID# 213113
city: Holzminden
country: Germany
facility: Reinecke, Holzminden, DE /ID# 215081
city: Karlsruhe
country: Germany
facility: Derma Sana /ID# 214544
city: Koblenz
country: Germany
facility: Grossmann, Koblenz, DE /ID# 214245
city: Krefeld
country: Germany
facility: Praxis Dres. Bornemann/Reinerth /ID# 213368
city: Kulmbach
country: Germany
facility: Dres. Jacobs & Kollegen /ID# 213652
city: Langenau
country: Germany
facility: Hautarztpraxis Langenau /ID# 213651
city: Leipzig
country: Germany
facility: Neubauer, Leipzig, DE /ID# 214548
city: Leipzig
country: Germany
facility: Noack-Wiemers, Leipzig, DE /ID# 213654
city: Loehne
country: Germany
facility: Hagemeier, Loehne, DE /ID# 214845
city: Luedenscheid
country: Germany
facility: Dlugosz-Wolf, Luedenscheid, DE /ID# 222000
city: Magdeburg
country: Germany
facility: Bruecher, Magdeburg, DE /ID# 213476
city: Magdeburg
country: Germany
facility: Praxis Dr. Raschke /ID# 225213
city: Magdeburg
country: Germany
facility: Universitaetsklinikum Magdeburg /ID# 215080
city: Mainz
country: Germany
facility: Dermatologie Quist-BAG Dres. med. Quist PartG /ID# 214249
city: Mönchengladbach
country: Germany
facility: ZENTderma /ID# 213959
city: Neuwied
country: Germany
facility: Duplicate_Praxis Dres. Kloss/Peterburgskiy /ID# 213960
city: Neuwied
country: Germany
facility: Zentrum fur Hautgesundheit /ID# 222001
city: Nuremberg
country: Germany
facility: Praxis Dr. Konstantin Ertner /ID# 213640
city: Nuremberg
country: Germany
facility: Voelkel, Nuremberg, DE /ID# 213671
city: Osnabrueck
country: Germany
facility: Breitsprecher, Osnabrueck, DE /ID# 213672
city: Remscheid
country: Germany
facility: Kramer/Mortazawi, Remscheid /ID# 213477
city: Schwelm
country: Germany
facility: Praxis Dr. Fränken /ID# 214546
city: Schwerin
country: Germany
facility: Praxis Dr. Langhoff /ID# 214253
city: Soest
country: Germany
facility: Karl, Soest, DE /ID# 214547
city: Stuttgart
country: Germany
facility: Praxis Dres. Ziegler & Partner /ID# 213647
city: Ueberlingen
country: Germany
facility: Braun, Ueberlingen, DE /ID# 213646
city: Waltershausen
country: Germany
facility: Barnikol, Waltershausen, DE /ID# 213219
city: Werdau
country: Germany
facility: Pfennig, Werdau, DE /ID# 213657
city: Wiesbaden
country: Germany
facility: Moeller, Wiesbaden, DE /ID# 213955
city: Witten
country: Germany
facility: Hautarztpraxis Dr. med. Matthias Hoffmann /ID# 213444
city: Wolfenbuettel
country: Germany
facility: Franz, Wolfenbuettel, DE /ID# 215355
city: Debrecen
country: Hungary
facility: Debreceni Egyetem-Klinikai Kozpont /ID# 212959
state: Hajdu-Bihar
city: Szombathely
country: Hungary
facility: Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 212961
state: Vas
city: Pecs
country: Hungary
facility: Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 212960
city: Szeged
country: Hungary
facility: Szegedi Tudományegyetem /ID# 212958
city: Tallaght
country: Ireland
facility: Tallaght University Hospital /ID# 212999
state: Dublin
city: Cork
country: Ireland
facility: South Infirmary Victoria University Hospital /ID# 213001
city: Limerick
country: Ireland
facility: University Hospital Limerick /ID# 216997
city: Torette
country: Italy
facility: Azienda Ospedaliero Universitaria Ospedali Riuniti Do Ancona /ID# 218720
state: Ancona
city: Germaneto
country: Italy
facility: Azienda Ospedaliera Universitaria Mater Domini- Campus Salvatore Venuta /ID# 218902
state: Catanzaro
city: Florence
country: Italy
facility: Università degli Studi di Firenze /ID# 221383
state: Firenze
city: Genoa
country: Italy
facility: Ospedale Policlinico San Martino /ID# 218844
state: Genova
city: L'Aquila
country: Italy
facility: Presidio Ospedaliero San Salvatore /ID# 218719
state: L Aquila
city: Rozzano
country: Italy
facility: Istituto Clinico Humanitas /ID# 218560
state: Milano
city: Rome
country: Italy
facility: Fondazione PTV Policlinico Tor Vergata /ID# 219031
state: Roma
city: Rome
country: Italy
facility: Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 218718
state: Roma
city: Perugia
country: Italy
facility: Azienda Ospedaliera di Perugia /ID# 219033
state: Umbria
city: Bari
country: Italy
facility: Azienda Ospedaliera Universitaria Consorziale Policlinico /ID# 218558
city: Brescia
country: Italy
facility: ASST Spedali civili di Brescia /ID# 218717
city: Catania
country: Italy
facility: Presidio Ospedaliero Gaspare Rodolico /ID# 219032
city: Milan
country: Italy
facility: IRCCS Policlinico San Donato /ID# 222002
city: Milan
country: Italy
facility: IRCCS Istituto Ortopedico Galeazzi /ID# 218867
city: Napoli
country: Italy
facility: Azienda Ospedaliera Universitaria Federico II /ID# 218808
city: Napoli
country: Italy
facility: AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 218546
city: Padova
country: Italy
facility: Azienda Ospedaliera di Padova /ID# 221299
city: Pisa
country: Italy
facility: Azienda Ospedaliero Universitaria Pisana /ID# 218555
city: Terracina
country: Italy
facility: Sapienza University of Rome - Polo Pontino /ID# 218557
city: Vicenza
country: Italy
facility: Azienda ULSS 8 Berica/Ospedale San Bortolo di Vicenza /ID# 218845
city: Nagoya shi
country: Japan
facility: Nagoya City University Hospital /ID# 213363
state: Aichi
city: Nagoya-shi
country: Japan
facility: Chukyo Hospital /ID# 213405
state: Aichi
city: Toyoake-shi
country: Japan
facility: Duplicate_Fujita Health University Hospital /ID# 224742
state: Aichi
city: Matsuyama-shi
country: Japan
facility: Matsuyama Red Cross Hospital /ID# 224745
state: Ehime
city: Fukuoka-shi
country: Japan
facility: Fukuoka University Hospital /ID# 213395
state: Fukuoka
city: Kurume-shi
country: Japan
facility: Kurume University Hospital /ID# 215034
state: Fukuoka
city: Asahikawa-shi
country: Japan
facility: Asahikawa Medical University Hospital /ID# 213409
state: Hokkaido
city: Obihiro-shi
country: Japan
facility: Takagi Dermatological Clinic Branch /ID# 213407
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: JR Sapporo Hospital /ID# 213406
state: Hokkaido
city: Takamatsu-shi
country: Japan
facility: Takamatsu Red Cross Hospital /ID# 222875
state: Kagawa
city: Takamatsu-shi
country: Japan
facility: Takamatsu Red Cross Hospital /ID# 241120
state: Kagawa
city: Kagoshima-shi
country: Japan
facility: Imamura General Hospital /ID# 228450
state: Kagoshima
city: Kyoto-shi
country: Japan
facility: University Hospital Kyoto Prefectural University of Medicine /ID# 213396
state: Kyoto
city: Kyoto-shi
country: Japan
facility: Kyoto University Hospital /ID# 213404
state: Kyoto
city: Tsu-shi
country: Japan
facility: Mie University Hospital /ID# 213387
state: Mie
city: Matsumoto-shi
country: Japan
facility: Shinshu University Hospital /ID# 213408
state: Nagano
city: Nakagami-gun
country: Japan
facility: University of the Ryukyus Hospital /ID# 213394
state: Okinawa
city: Hirakata-shi
country: Japan
facility: Kansai Medical University Hospital /ID# 213388
state: Osaka
city: Osaka-shi
country: Japan
facility: Nippon Life Saiseikai Public Interest Foundation Nippon Life Hospital /ID# 224743
state: Osaka
city: Shizuoka-shi
country: Japan
facility: Shizuoka General Hospital /ID# 224744
state: Shizuoka
city: Shimotsuke-shi
country: Japan
facility: Jichi Medical University Hospital /ID# 213403
state: Tochigi
city: Bunkyo-ku
country: Japan
facility: Nippon Medical School Hospital /ID# 213391
state: Tokyo
city: Chuo-ku
country: Japan
facility: St.Luke's International Hospital /ID# 213392
state: Tokyo
city: Minato-ku
country: Japan
facility: The Jikei University Hospital /ID# 213393
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Tokyo Medical University Hospital /ID# 217125
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Japan Community Health care Organization Tokyo Yamate Medical Center /ID# 213389
state: Tokyo
city: Tokyo
country: Japan
facility: Teikyo University /ID# 213362
city: Tijuana
country: Mexico
facility: Dermatologica Sc /Id# 225449
state: Baja California
city: Ciudad de México
country: Mexico
facility: Consultorio Privado /Id# 225457
state: Ciudad De Mexico
city: Ciudad de México
country: Mexico
facility: Clinica Los Arcos Iztapalapa /Id# 216982
state: Ciudad De Mexico
city: Mexico City
country: Mexico
facility: RM Pharma Specialists S.A de C.V. /ID# 225458
state: Ciudad De Mexico
city: Guadalajara
country: Mexico
facility: Centro Dermatologico Del Country S de Rl de Cv /Id# 225460
state: Jalisco
city: Guadalajara
country: Mexico
facility: Grupo Clinico Catei Sociedad Civil /Id# 216978
state: Jalisco
city: Mexico City
country: Mexico
facility: Centro Especializado en Diabetes, Obesidad y Prevencion de Enfermedades Cardiova /ID# 216979
city: Toluca
country: Mexico
facility: Neki Servicios Medicos Profesionales S D Rl de Cv /Id# 216977
city: Nijmegen
country: Netherlands
facility: Radboud Universitair Medisch Centrum /ID# 213592
state: Gelderland
city: Roermond
country: Netherlands
facility: Laurentius Ziekenhuis /ID# 230503
state: Limburg
city: Den Haag
country: Netherlands
facility: Haaglanden Medisch Centrum /ID# 232063
city: Leeuwarden
country: Netherlands
facility: Medisch Centrum Leeuwarden /ID# 215779
city: Warszawa
country: Poland
facility: Panstwowy Instytut Medyczny MSWiA w Warszawie /ID# 225415
state: Mazowieckie
city: Rzeszow
country: Poland
facility: KSW nr1 w Rzeszowie /ID# 225444
state: Podkarpackie
city: Gdansk
country: Poland
facility: COPERNICUS Podmiot Leczniczy Sp. z o.o. - Szpital sw. Wojciecha Adalberta /ID# 225446
state: Pomorskie
city: Ozarowice
country: Poland
facility: Labderm S.C. Beata Bergler-Czop, Barbara Sido-Bergler /Id# 225447
state: Slaskie
city: Bucuresti
country: Romania
facility: Spitalul Clinic Colentina /ID# 214307
city: Bucuresti
country: Romania
facility: Spitalul Clinic Colentina /ID# 224810
city: Bucuresti
country: Romania
facility: Spitalul Clinic Colentina /ID# 224811
city: Jassi
country: Romania
facility: Spitalul Clinic Județean de Urgențe "Sfântul Spiridon" /ID# 214335
city: Riyadh
country: Saudi Arabia
facility: King Abdulaziz Medical City- National Guard Hospital /ID# 224354
state: Ar Riyad
city: Makkah
country: Saudi Arabia
facility: Heraa General Hospital /ID# 217214
city: Riyadh
country: Saudi Arabia
facility: King Saud University Med City /ID# 219065
city: Riyadh
country: Saudi Arabia
facility: Security Forces Hospital /ID# 221073
city: Santiago de Compostela
country: Spain
facility: Hospital Clínico Universitario de Santiago-CHUS /ID# 225076
state: A Coruna
city: Manacor
country: Spain
facility: Hospital de Manacor /ID# 225083
state: Balears
city: Puerto Real
country: Spain
facility: Hospital Universitario de Puerto Real /ID# 225103
state: Cadiz
city: Palma de Mallorca
country: Spain
facility: Hospital Universitari Son Espases /ID# 233286
state: Illes Balears
city: Alcala de Henares
country: Spain
facility: Hospital Universitario Principe de Asturias /ID# 225085
state: Madrid
city: Arganda del Rey
country: Spain
facility: Hospital Universitario del Sureste /ID# 226561
state: Madrid
city: Getafe
country: Spain
facility: Hospital Universitario de Getafe /ID# 225086
state: Madrid
city: Leganes
country: Spain
facility: Hospital Universitario Severo Ochoa /ID# 225087
state: Madrid
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro - Majadahonda /ID# 225084
state: Madrid
city: Mostoles
country: Spain
facility: Hospital General de Mostoles /ID# 225088
state: Madrid
city: Cartagena
country: Spain
facility: Hospital Santa María del Rosell /ID# 225100
state: Murcia
city: Vigo
country: Spain
facility: Hospital Alvaro Cunqueiro CHUVI /ID# 225077
state: Pontevedra
city: Badajoz
country: Spain
facility: Hospital Universitario de Bajadoz /ID# 225091
city: Granada
country: Spain
facility: Hospital Universitario Virgen de las Nieves /ID# 225107
city: Huelva
country: Spain
facility: Hospital Juan Ramon Jimenez /ID# 225105
city: Leon
country: Spain
facility: Hospital de Leon /ID# 226559
city: Lugo
country: Spain
facility: Hospital Universitario Lucus Augusti /ID# 233282
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Maranon /ID# 231664
city: Madrid
country: Spain
facility: Hospital Universitario Ramon y Cajal /ID# 225093
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre /ID# 238474
city: Palencia
country: Spain
facility: Hospital San Telmo /ID# 233283
city: Salamanca
country: Spain
facility: Hospital Universitario de Salamanca /ID# 225078
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen de Valme /ID# 225104
city: Zamora
country: Spain
facility: Hospital Virgen de la Concha /ID# 233285
city: Zaragoza
country: Spain
facility: Hospital Clinico Universitario Lozano Blesa /ID# 231663
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet /ID# 225080
city: Zaragoza
country: Spain
facility: Hospital Royo Villanova /ID# 231665
city: Basel Town
country: Switzerland
facility: Universitätsspital Basel /ID# 212744
state: Basel-Stadt
city: Obburgen
country: Switzerland
facility: Waldhotel Health & Medical Excellence /Id# 212743
state: Nidwalden
city: Uster
country: Switzerland
facility: Haut. Venen. Allergie. Zentrum Brunnehof /ID# 212742
state: Zuerich
city: Zurich
country: Switzerland
facility: University Hospital Zurich /ID# 216539
state: Zuerich
city: Bern
country: Switzerland
facility: Inselspital, Universitaetsspital Bern /ID# 212741
city: Abu Dhabi
country: United Arab Emirates
facility: Mediclinic Khalifa Branch /ID# 217871
city: Abu Dhabi
country: United Arab Emirates
facility: New Medical Center Hospital /ID# 223681
city: Abu Dhabi
country: United Arab Emirates
facility: Skmc /Id# 217873
city: Abu Dhabi
country: United Arab Emirates
facility: Tawam Hospital /ID# 217872
city: Dubai
country: United Arab Emirates
facility: Mediclinic Welcare Hospital /ID# 223683
city: Cambridge
country: United Kingdom
facility: Addenbrooke's Hospital /ID# 215972
state: Cambridgeshire
city: London
country: United Kingdom
facility: Imperial College London - St Mary's Hospital /ID# 215978
state: London, City Of
city: Kings Lynn
country: United Kingdom
facility: The Queen Elizabeth Hospital, Kings Lynn NHS Foundation Trust /ID# 215476
state: Norfolk
city: Northampton
country: United Kingdom
facility: Northampton General Hospital NHS Trust /ID# 249297
state: Northamptonshire
city: Bury St Edmunds
country: United Kingdom
facility: West Suffolk Hospital /ID# 249283
state: Suffolk
city: Camberley
country: United Kingdom
facility: Frimley Health NHS Foundation Trust /ID# 215976
state: Surrey
city: Kingston upon Thames
country: United Kingdom
facility: Kingston Hospital NHS Foundation Trust /ID# 215973
state: Surrey
city: Kingston upon Thames
country: United Kingdom
facility: Kingston Hospital NHS Foundation Trust /ID# 230856
state: Surrey
city: Bridgend
country: United Kingdom
facility: Cwm Taf Morgannwg University Health Board /ID# 215974
state: Wales
city: Belfast
country: United Kingdom
facility: Ulster Hospital - South Eastern Health & Social Care Trust /ID# 215477
city: Dudley
country: United Kingdom
facility: The Dudley Group NHS Foundation Trust /ID# 215839
city: Edinburgh
country: United Kingdom
facility: NHS Lothian /ID# 249287
city: Lyndon
country: United Kingdom
facility: Sandwell and West Birmingham Hospitals NHS Trust /ID# 249294
city: Manchester
country: United Kingdom
facility: Northern Care Alliance NHS Group /ID# 218589
city: Newcastle upon Tyne
country: United Kingdom
facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 215479
city: York
country: United Kingdom
facility: York and Scarborough Teaching Hospitals NHS Foundation Trust /ID# 227940
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References: