Clinical trial NCT05294029: Neuro-Orthopaedic Disorders During Aging in Patients With Neuromotor Disability
Official title: Neuro-Orthopaedic Disorders During Aging in Patients With Neuromotor Disability
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Disability or Chronic Disease Leading to Disablement
Keywords: Neuromotor Disability, Neuro-Orthopaedics
Lead sponsor: Institut de Sante Parasport Connecte Synergies
Sponsor class: OTHER
Collaborators: name: Assistance Publique - Hôpitaux de Paris
First posted: 2022-03-24
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects with neuromotor disability

Brief summary: People with neuromotor disability (i.e. following an inborn or acquired spinal cord, cerebral or peripheral neurological lesion) are at risk of worsening their neuro-orthopaedic disorders during aging, including fracture risk. Nevertheless, at the present time, the natural evolution of their neuro-orthopedic disorders and the long-term functional impact of their medical and surgical treatments is unknown.

The aim of this study is to describe neuro-orthopedic disorders during aging of patients with neuromotor disability, their functional repercussions, their comorbidities and the therapeutic strategies used.

Detailed description: This is an ambispective, monocentric, cohort study of subjects with neuromotor disability followed in a Physical Medicine and Rehabilitation Department.

All consecutive eligible inpatient and outpatient subjects treated in the Neuro Orthopaedic Unit (UPOH) of the Physical Medicine and Rehabilitation Department of our university hospital will be included.

Data will be collected from the patients' medical records, in particular data related to their clinical, radiological, biological and physiological examinations.

Eligibility criteria: Inclusion Criteria:

* Patients \>= 18 years old ;
* Treated in the Neuro Orthopaedic Unit (UPOH) of the Physical Medicine and Rehabilitation Department of our university hospital ;
* Having a neuromotor disability ;
* No opposition to be enrolled in the study from the patient, or from a legally authorized close relative if the patient's state of health does not allow it ;
* Affiliation to a social security scheme.

Exclusion Criteria:

* Under court protection.

Primary outcomes:
measure: Evolution of mobility during aging
timeFrame: Through study completion, an average of 1 year
Secondary outcomes:
measure: Prevalence of falls and fractures
timeFrame: Through study completion, an average of 1 year
measure: Characteristics of infiltrative procedures and surgeries
timeFrame: Through study completion, an average of 1 year
measure: Changes of devices (orthoses and prostheses) and technical aids used during aging
timeFrame: Through study completion, an average of 1 year
measure: Changes of physical activity, as well as barriers and facilitators to physical activity, during aging
timeFrame: Through study completion, an average of 1 year
measure: Evolution of comorbidities during aging
timeFrame: Through study completion, an average of 1 year
measure: Medication
timeFrame: Through study completion, an average of 1 year
measure: Prevalence of pressure sores
timeFrame: Through study completion, an average of 1 year
Other outcomes:
Locations:
city: Garches
country: France
facility: Department of Physical Medicine and Rehabilitation, Raymond Poincaré Hospital, AP-HP
Study officials:
affiliation: Department of Physical Medicine and Rehabilitation, Raymond Poincaré Hospital, AP-HP, 92380 Garches, France
name: François Genêt, MD-PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Department of Physical Medicine and Rehabilitation, Raymond Poincaré Hospital, AP-HP, 92380 Garches, France
name: Vincent T Carpentier, MD-MSc
role: STUDY_DIRECTOR
References: