Clinical trial NCT07004426: Symptomatic and Incidental RCC Detection
Official title: Assessment of Symptomatic and Incidental Detection of Renal Cell Carcinoma Using Standard Imaging Modalities
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Renal Cell Carcinoma (Kidney Cancer)
Benign Renal Neoplasm
Renal Carcinoma
Keywords: Renal cell carcinoma
Detection
Imaging modalities
Non-neoplastic renal lesions
Lead sponsor: Charles University, Czech Republic
Sponsor class: OTHER
Collaborators: name: University Hospital Kralovske Vinohrady
First posted: 2025-06-04
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients treated for renal lesions at the Urology Department of University Hospital Královské Vinohrady

Brief summary: Evaluation of the frequency of symptomatic and incidental detection of renal carcinoma at different stages depending on the imaging modality used

Detailed description: In the Czech Republic, there is no screening program for renal cell carcinoma. Existing evidence suggests that incidental detection of this cancer tends to occur in its early stages, which are more manageable due to effective treatment options, ultimately reducing renal cancer mortality. This highlights the potential value of evaluating current imaging modalities and determining their role in secondary prevention. This cross-sectional study, based on hospital data, aims to contribute to a better understanding of this issue and to assess the effectiveness of imaging techniques in the early detection of renal cell carcinoma. Furthermore, data analysis may reveal the influence of risk factors on the detection of tumors at various stages.

Eligibility criteria: Inclusion Criteria:

* patients over 18 years of age undergoing surgical treatment for renal lesions

Exclusion Criteria:

* patients undergoing surgery for non-renal and urotelial carcinoma, including unknown
* patients with recurrent renal lesions

Primary outcomes:
measure: Detection-specific renal cell carcinoma (RCC) proportions
timeFrame: From 2011 to 2020
Secondary outcomes:
measure: Proportion of RCC among neoplastic and non-neoplastic renal lesions
timeFrame: From 2011 to 2020
Other outcomes:
Locations:
city: Prague
country: Czechia
facility: University Hospital Královské Vinohrady
Study officials:
affiliation: Vascular surgery, University hospital Královské Vinohrady, Prague
name: Jindřich Šonský, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Vascular surgery, University hospital Královské Vinohrady, Prague
name: Alexandra Gregušová, MD
role: STUDY_CHAIR
affiliation: Vascular surgery, University hospital Královské Vinohrady, Prague
name: Jakub Hanych, MD
role: STUDY_CHAIR
affiliation: Vascular surgery, University hospital Královské Vinohrady, Prague
name: Robert Grill, assoc. prof., MD, PhD
role: STUDY_DIRECTOR
affiliation: Vascular surgery, University hospital Královské Vinohrady, Prague
name: Kateřina Licková, MD, PhD
role: STUDY_CHAIR
affiliation: Vascular surgery, University hospital Královské Vinohrady, Prague
name: Jana Malinová, MD, PhD
role: STUDY_CHAIR
affiliation: Ostrava University Hospital
name: Tomáš Blažek, MD, PhD
role: STUDY_CHAIR
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