Clinical trial NCT06827340: Multiparametric Whole-Body MRI: a Game Changer in Metastatic Prostate Cancer
Official title: Multiparametric Whole-Body MRI: a Game Changer in Metastatic Prostate Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Prostate Cancer (Adenocarcinoma)
Lead sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sponsor class: OTHER
First posted: 2025-02-14
Enrollment: 104
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Literature with patients with metastatic prostate cancer.

Brief summary: WB-MRI is a next-generation imaging technique standardized with the first version of MET-RADs-P guidelines.This narrative review aims to analyse the main scientific evidence available in the literature, explaining what WB MRI is and showing its decisive role in metastatic PC.

Detailed description: Prostate cancer ranks among the most prevalent tumours globally. While early detection reduces the likelihood of metastasis, managing advanced cases poses challenges in diagnosis and treatment. Current international guidelines support the concurrent use of 99Tc-Bone Scintigraphy and Contrast-Enhanced Chest and Abdomen CT for the staging of metastatic disease and response assessment. However, emerging evidence underscores the superiority of next-generation imaging techniques including PSMA-PET/CT and whole-body MRI (WB-MRI). This review explores the relevant scientific literature on the role of WB-MRI in metastatic prostate cancer. This multiparametric imaging technique, combining the high anatomical resolution of standard MRI sequences with functional sequences such as diffusion-weighted imaging (DWI) and bone marrow relative fat fraction (rFF%) has proved effective in comprehensive patient assessment, evaluating local disease, most of the nodal involvement, bone metastases and their complications, and detecting the increasing visceral metastases in prostate cancer. It does have the advantage of avoiding the injection of contrast medium/radionuclide administration, spares the patient the exposure to ionizing radiation, and lacks the confounder of FLARE described with nuclear medicine techniques. Up-to-date literature regarding the diagnostic capabilities of WB-MRI, though still limited compared to PSMA-PET/CT, strongly supports its widespread incorporation into standard clinical practice, alongside the latest nuclear medicine techniques.

Eligibility criteria: Inclusion Criteria: Literature extracted through the PubMed search engine, following PRISMA checklist, using the keywords:

* "Whole Body MRI"
* "Diffusion Weighted Imaging"
* "PET-CT and WB-MRI"
* "Metastatic Prostate Cancer"
* "Biochemical Recurrence in Metastatic Prostate Cancer"
* "DWIBS"
* "Multiparametric MRI"
* "response assessment in metastatic prostate cancer"
* "Dixon Method",
* "bone biopsy in metastatic prostate cancer",
* "bone metastases in prostate cancer",
* "MET-RADs".
* analysis from 1995 to April 2024.

Exclusion Criteria:

* duplicates
* repetitive,
* irrelevant,
* unrelated,
* out-of-date guidelines,
* case reports

Primary outcomes:
measure: Identifying the imaging features of metastatic PC in WB-MRI
timeFrame: from 1995 to april 2024
measure: Evaluation of Bone Metastases with WB-MRI
timeFrame: from 1995 to April 2024
measure: Assessment of Nodal Disease
timeFrame: from 1995 to april 2024
measure: Assessment of Visceral Disease
timeFrame: from 1995 to april 2024
measure: Assessing Local Disease and Biochemical Recurrence
timeFrame: from 1995 to april 2024
measure: Response Assessment in Metastatic Prostate Cancer
timeFrame: from 1995 to april 2024
Secondary outcomes:
Other outcomes:
Locations:
city: Bologna
country: Italy
facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Study officials:
affiliation: IRCCS Azienda Ospedaliero-Universitaria di Bologna
name: Lorenzo Bianchi
role: PRINCIPAL_INVESTIGATOR
References: