Clinical trial NCT04432831: A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Diabetic Macular Edema
Official title: A Multicenter, Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Patients With Diabetic Macular Edema
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Diabetic Macular Edema
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2020-06-16
Enrollment: 1479
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a multicenter long-term extension study designed to evaluate the long-term safety and tolerability of faricimab administered by intravitreal (IVT) injection at a personalized treatment interval (PTI) to participants who enrolled in and completed one of the two Phase III studies, GR40349 (NCT03622580) or GR40398 (NCT03622593), also referred to as the parent studies.


Eligibility criteria: Inclusion Criteria:

* Previous enrollment in and completion of Study GR40349 (NCT03622580) or GR40398 (NCT03622593), without study or study drug discontinuation
* Ability to comply with the study protocol, in the investigator's judgment
* For women of childbearing potential: agreement to remain abstinent or use acceptable contraceptive methods that result in a failure rate of \<1% per year during the treatment period and for at least 3 months after the final dose of study treatment

Exclusion Criteria:

* Pregnant or breastfeeding, or intending to become pregnant during the study or within 3 months after the final intravitreal injection of faricimab
* Presence of other ocular diseases that give reasonable suspicion of a disease or condition that contraindicates the use of faricimab, that might affect interpretation of the results of the study or that renders the patient at high risk for treatment complications
* Presence of other diseases, metabolic dysfunction, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of faricimab and that might affect interpretation of the results of the study or that renders the patient at high risk of treatment complications
* History of a severe allergic reaction or anaphylactic reaction to a biologic agent or known hypersensitivity to any component of the faricimab injections, study treatment procedure, dilating drops, or any of the anesthetic and antimicrobial preparations used by a patient during the study
* Requirement for continuous use of any medications or treatments indicated as prohibited therapy

Primary outcomes:
measure: Incidence and Severity of Ocular Adverse Events in the Study Eye, With Severity Determined According to Adverse Event Severity Grading Scale
timeFrame: From the day of the first dose of faricimab until the end of the study (up to 108 weeks)
measure: Incidence of Ocular Adverse Events in the Fellow Eye
timeFrame: From the day of the first dose of faricimab until the end of the study (up to 108 weeks)
measure: Incidence and Severity of Non-Ocular Adverse Events, With Severity Determined According to Adverse Event Severity Grading Scale
timeFrame: From the day of the first dose of faricimab until the end of the study (up to 108 weeks)
Secondary outcomes:
Other outcomes:
Locations:
city: Mesa
country: United States
facility: Barnet Dulaney Perkins Eye Center
state: Arizona
city: Phoenix
country: United States
facility: Retinal Research Institute, LLC
state: Arizona
city: Phoenix
country: United States
facility: Arizona Retina and Vitreous Consultants
state: Arizona
city: Tucson
country: United States
facility: Retina Associates Southwest PC
state: Arizona
city: Bakersfield
country: United States
facility: California Retina Consultants.
state: California
city: Beverly Hills
country: United States
facility: Retina-Vitreous Associates Medical Group
state: California
city: Campbell
country: United States
facility: Retinal Diagnostic Center
state: California
city: Encino
country: United States
facility: The Retina Partners
state: California
city: Fresno
country: United States
facility: Eye Medical Center
state: California
city: Fullerton
country: United States
facility: Retina Consultants of Orange County
state: California
city: Los Angeles
country: United States
facility: Southern California Permanente Medical Group
state: California
city: Mountain View
country: United States
facility: Northern California Retina Vitreous Associates
state: California
city: Oakland
country: United States
facility: East Bay Retina Consultants
state: California
city: Palm Desert
country: United States
facility: Southern CA Desert Retina Cons
state: California
city: Pasadena
country: United States
facility: California Eye Specialists Medical group Inc.
state: California
city: Poway
country: United States
facility: Retina Consultants, San Diego
state: California
city: Redlands
country: United States
facility: Retina Consultants of Southern California
state: California
city: Sacramento
country: United States
facility: Retinal Consultants Med Group
state: California
city: San Francisco
country: United States
facility: West Coast Retina Medical Group
state: California
city: Santa Ana
country: United States
facility: Orange County Retina Med Group
state: California
city: Santa Barbara
country: United States
facility: California Retina Consultants
state: California
city: Santa Maria
country: United States
facility: California Retina Consultants - Santa Maria
state: California
city: Walnut Creek
country: United States
facility: Bay Area Retina Associates
state: California
city: Aurora
country: United States
facility: University of Colorado; dept of ophthalmology
state: Colorado
city: Colorado Springs
country: United States
facility: Retina Consultants of Southern
state: Colorado
city: Lakewood
country: United States
facility: Colorado Retina Associates, PC
state: Colorado
city: Waterford
country: United States
facility: Retina Group of New England
state: Connecticut
city: Deerfield Beach
country: United States
facility: Rand Eye
state: Florida
city: Fort Lauderdale
country: United States
facility: Retina Group of Florida
state: Florida
city: Fort Myers
country: United States
facility: National Ophthalmic Research Institute
state: Florida
city: Melbourne
country: United States
facility: Florida Eye Associates
state: Florida
city: Palm Beach Gardens
country: United States
facility: Retina Care Specialists
state: Florida
city: Pensacola
country: United States
facility: Retina Specialty Institute
state: Florida
city: Plantation
country: United States
facility: Fort Lauderdale Eye Institute
state: Florida
city: Saint Petersburg
country: United States
facility: Retina Vitreous Assoc of FL
state: Florida
city: Tallahassee
country: United States
facility: Southern Vitreoretinal Assoc
state: Florida
city: Tampa
country: United States
facility: Retina Associates of Florida, LLC
state: Florida
city: Augusta
country: United States
facility: Southeast Retina Center
state: Georgia
city: Marietta
country: United States
facility: Georgia Retina PC
state: Georgia
city: 'Aiea
country: United States
facility: Retina Consultants of Hawaii
state: Hawaii
city: Oak Forest
country: United States
facility: University Retina and Macula Associates, PC
state: Illinois
city: Springfield
country: United States
facility: Prairie Eye & LASIK Center / Prairie Retina Center
state: Illinois
city: Indianapolis
country: United States
facility: Midwest Eye Institute
state: Indiana
city: West Des Moines
country: United States
facility: Wolfe Eye Clinic
state: Iowa
city: Lenexa
country: United States
facility: Retina Associates
state: Kansas
city: Wichita
country: United States
facility: Vitreo-Retinal Consultants
state: Kansas
city: Lexington
country: United States
facility: Retina Associates of Kentucky
state: Kentucky
city: Portland
country: United States
facility: Maine Eye Center
state: Maine
city: Baltimore
country: United States
facility: The Retina Care Center
state: Maryland
city: Baltimore
country: United States
facility: Johns Hopkins Med; Wilmer Eye Inst
state: Maryland
city: Chevy Chase
country: United States
facility: Retina Group of Washington
state: Maryland
city: Hagerstown
country: United States
facility: Cumberland Valley Retina PC
state: Maryland
city: Towson
country: United States
facility: Retina Specialists
state: Maryland
city: Boston
country: United States
facility: Tufts Medical Center; Ophthalmology
state: Massachusetts
city: Boston
country: United States
facility: Ophthalmic Consultants of Boston
state: Massachusetts
city: Boston
country: United States
facility: Beetham Eye Institute, Joslin Diabetes Center
state: Massachusetts
city: Worcester
country: United States
facility: Vitreo-Retinal Associates, PC
state: Massachusetts
city: Grand Rapids
country: United States
facility: Associated Retinal Consultants
state: Michigan
city: Grand Rapids
country: United States
facility: Foundation for Vision Research
state: Michigan
city: Grand Rapids
country: United States
facility: Vitreo-Retinal Associates
state: Michigan
city: Royal Oak
country: United States
facility: Assoc Retinal Consultants PC
state: Michigan
city: Traverse City
country: United States
facility: Associated Retinal Consultants, P.C.
state: Michigan
city: Edina
country: United States
facility: VitreoRetinal Surgery, PLLC.; DBA Retina Consultants of Minnesota
state: Minnesota
city: Chesterfield
country: United States
facility: Midwest Vision Research Foundation
state: Missouri
city: Reno
country: United States
facility: Sierra Eye Associates
state: Nevada
city: Edison
country: United States
facility: NJRetina
state: New Jersey
city: Northfield
country: United States
facility: Retinal & Ophthalmic Cons PC
state: New Jersey
city: Teaneck
country: United States
facility: Retina Associates of NJ
state: New Jersey
city: Albuquerque
country: United States
facility: University of New Mexico
state: New Mexico
city: Albany
country: United States
facility: Capital Region Retina
state: New York
city: Hauppauge
country: United States
facility: Long Is. Vitreoretinal Consult
state: New York
city: Liverpool
country: United States
facility: Retina Vit Surgeons/Central NY
state: New York
city: New York
country: United States
facility: New York University
state: New York
city: Oceanside
country: United States
facility: Ophthalmic Cons of Long Island
state: New York
city: Rochester
country: United States
facility: Retina Associates of Western New York
state: New York
city: Shirley
country: United States
facility: Island Retina
state: New York
city: Slingerlands
country: United States
facility: The Retina Consultants
state: New York
city: Asheville
country: United States
facility: Western Carolina Retinal Associate PA
state: North Carolina
city: Charlotte
country: United States
facility: Char Eye Ear &Throat Assoc
state: North Carolina
city: Hickory
country: United States
facility: Graystone Eye
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest Baptist Health Eye Centre
state: North Carolina
city: Cincinnati
country: United States
facility: Cincinnati Eye Institute
state: Ohio
city: Cleveland
country: United States
facility: Retina Assoc of Cleveland Inc
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic Foundation; Cole Eye Institute
state: Ohio
city: Columbus
country: United States
facility: The Ohio State University Havener Eye Institute
state: Ohio
city: Dublin
country: United States
facility: Midwest Retina
state: Ohio
city: Edmond
country: United States
facility: Retina Vitreous Center
state: Oklahoma
city: Portland
country: United States
facility: Retina Northwest
state: Oregon
city: Philadelphia
country: United States
facility: Mid Atlantic Retina - Wills Eye Hospital
state: Pennsylvania
city: Philadelphia
country: United States
facility: Mid-Atlantic Retina
state: Pennsylvania
city: Greenville
country: United States
facility: Retina Consultants Of Carolina
state: South Carolina
city: Ladson
country: United States
facility: Charleston Neuroscience Inst
state: South Carolina
city: West Columbia
country: United States
facility: Palmetto Retina Center
state: South Carolina
city: Chattanooga
country: United States
facility: Southeastern Retina Associates Chattanooga
state: Tennessee
city: Germantown
country: United States
facility: Charles Retina Institute
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Retina PC
state: Tennessee
city: Abilene
country: United States
facility: Retina Res Institute of Texas
state: Texas
city: Austin
country: United States
facility: Austin Retina Associates
state: Texas
city: Austin
country: United States
facility: Austin Clinical Research LLC
state: Texas
city: Bellaire
country: United States
facility: Retina & Vitreous of Texas
state: Texas
city: Dallas
country: United States
facility: Texas Retina Associates
state: Texas
city: Harlingen
country: United States
facility: Valley Retina Institute P.A.
state: Texas
city: San Antonio
country: United States
facility: Medical Center Ophthalmology Associates
state: Texas
city: Southlake
country: United States
facility: Retina Center of Texas
state: Texas
city: The Woodlands
country: United States
facility: Retina Consultants of Texas
state: Texas
city: Tyler
country: United States
facility: Eye Care Assoc of East Texas
state: Texas
city: Willow Park
country: United States
facility: Strategic Clinical Research Group, LLC
state: Texas
city: Salt Lake City
country: United States
facility: Retina Associates of Utah, PLLC
state: Utah
city: Salt Lake City
country: United States
facility: University of Utah; Division of Gastroenterology/Hepatology
state: Utah
city: Burlington
country: United States
facility: Uni of Vermont Medical Center;
state: Vermont
city: Charlottesville
country: United States
facility: Univ of Virginia Ophthalmology
state: Virginia
city: Falls Church
country: United States
facility: Emerson Clinical Research Institute
state: Virginia
city: Lynchburg
country: United States
facility: Piedmont Eye Center
state: Virginia
city: Norfolk
country: United States
facility: Wagner Kapoor Institute
state: Virginia
city: Richmond
country: United States
facility: Retina Institute of Virginia
state: Virginia
city: Morgantown
country: United States
facility: West Virginia University Eye Institute
state: West Virginia
city: Madison
country: United States
facility: University of Wisconsin
state: Wisconsin
city: Caba
country: Argentina
facility: Fundacion Zambrano
city: Capital Federal
country: Argentina
facility: Oftalmos
city: Mendoza
country: Argentina
facility: Oftar
city: Rosario
country: Argentina
facility: Centro Oftalmólogos Especialistas
city: Rosario
country: Argentina
facility: Grupo Laser Vision
city: San Nicolás
country: Argentina
facility: Organizacion Medica de Investigacion
city: Strathfield
country: Australia
facility: Strathfield Retina Clinic
state: New South Wales
city: Sydney
country: Australia
facility: Sydney Eye Hospital
state: New South Wales
city: Sydney
country: Australia
facility: Sydney Retina Clinic and Day Surgery
state: New South Wales
city: Westmead
country: Australia
facility: Sydney West Retina
state: New South Wales
city: East Melbourne
country: Australia
facility: Centre For Eye Research Australia
state: Victoria
city: Rowville
country: Australia
facility: Retina Specialists Victoria
state: Victoria
city: Nedlands
country: Australia
facility: The Lions Eye Institute
state: Western Australia
city: Graz
country: Austria
facility: LKH-Univ.Klinikum Graz; Universitäts-Augenklinik
city: Linz
country: Austria
facility: Kepler Universitätskliniken GmbH - Med Campus III; Abt. für Augenheilkunde
city: Wien
country: Austria
facility: Medizinische Universität Wien; Universitätsklinik für Augenheilkunde und Optometrie
city: Wien
country: Austria
facility: Hanusch Krankenhaus; Abteilung für Augenkrankheiten mit Augen-Tagesklinik
city: Aparecida de Goiania
country: Brazil
facility: Hospital de Olhos de Aparecida - HOA
state: GO
city: Goiania
country: Brazil
facility: Centro Brasileiro de Cirurgia
state: GO
city: Porto Alegre
country: Brazil
facility: Hospital das Clinicas - UFRGS
state: RS
city: Blumenau
country: Brazil
facility: Botelho Hospital da Visao
state: SC
city: Santo Andre
country: Brazil
facility: Faculdade de Medicina do ABC - FMABC
state: SP
city: Sao Paulo
country: Brazil
facility: Universidade Federal de Sao Paulo - UNIFESP*X; Oftalmologia
state: SP
city: Sao Paulo
country: Brazil
facility: CEMAPE - Centro Médico
state: SP
city: Sao Paulo
country: Brazil
facility: Hospital das Clinicas - FMUSP
state: SP
city: Sorocaba
country: Brazil
facility: Hosp de Olhos de Sorocaba
state: SP
city: Sofia
country: Bulgaria
facility: Medical Center for Eye Health ? Focus Ltd
city: Sofia
country: Bulgaria
facility: Pentagram Eye Hospital (Medical Center "Pentagram")
city: Sofia
country: Bulgaria
facility: Spec. Ophth. Hospital for Active Treatment- Academic Pashev
city: Sofia
country: Bulgaria
facility: Specialized Hospital for Active Treatment of Eye Diseases Zora
city: Calgary
country: Canada
facility: Calgary Retina Consultants
state: Alberta
city: Halifax
country: Canada
facility: QEII - HSC Department of Ophthalmology
state: Nova Scotia
city: London
country: Canada
facility: Ivey Eye Institute
state: Ontario
city: Toronto
country: Canada
facility: Toronto Retina Institute
state: Ontario
city: Toronto
country: Canada
facility: St. Michael's Hospital; Department of Ophthalmology
state: Ontario
city: Toronto
country: Canada
facility: University Health Network Toronto Western Hospital
state: Ontario
city: Boisbriand
country: Canada
facility: Institut De L'Oeil Des Laurentides
state: Quebec
city: Hradec Králové
country: Czechia
facility: FN Hradec Králové, O?ní klinika; Ophthalmology clinic
city: Ostrava
country: Czechia
facility: Faculty Hospital Ostrava; Ophthalmology clinic
city: Prague
country: Czechia
facility: Faculty Hospital Kralovske Vinohrady; Ophthalmology clinic
city: Prague
country: Czechia
facility: AXON Clinical
city: Sokolov
country: Czechia
facility: Nemocnice Sokolov
city: Aalborg
country: Denmark
facility: Aalborg Universitetshospital; Øjenafdelingen
city: Roskilde
country: Denmark
facility: Sjællands Universitetshospital, Roskilde; Øjenafdelingen
city: Bordeaux
country: France
facility: Centre Hospitalier Universitaire de Bordeaux Hopital Pellegrin
city: Creteil
country: France
facility: Chi De Creteil; Ophtalmologie
city: Ecully
country: France
facility: Pole Vision Val d'Ouest; Ophtalmologie
city: Nantes
country: France
facility: CHU Nantes - Hôtel Dieu; Ophthalmology
city: Paris
country: France
facility: Hopital Lariboisiere; Ophtalmologie
city: St Cyr Sur Loire
country: France
facility: Centres Ophtalmologique St Exupéry; Ophtalmologie
city: Dresden
country: Germany
facility: Universitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Augenheilkunde
city: Freiburg
country: Germany
facility: Universitätsklinikum Freiburg, Klinik für Augenheilkunde
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover, Klinik für Augenheilkunde
city: Homburg/Saar
country: Germany
facility: Universitätsklinikum des Saarlandes; Klinik für Augenheilkunde
city: Magdeburg
country: Germany
facility: Universitätsklinikum Magdeburg A.ö.R., Universitätsaugenklinik
city: München
country: Germany
facility: LMU Klinikum der Universität, Augenklinik
city: München
country: Germany
facility: Klinikum rechts der Isar der TU München; Augenklinik
city: Münster
country: Germany
facility: Augenabteilung am St. Franziskus-Hospital
city: Münster
country: Germany
facility: Universitätsklinikum Münster; Augenheilkunde
city: Würzburg
country: Germany
facility: Universitätsklinikum Würzburg, Augenklinik und Poliklinik
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital; Department of Ophthalmology
city: Mongkok
country: Hong Kong
facility: Hong Kong Eye Hospital; CUHK Eye Centre
city: Budapest
country: Hungary
facility: Eszak-Pesti Centrumkorhaz - Honvedkorhaz; Szemeszet
city: Budapest
country: Hungary
facility: Peterfy Sandor utcai Korhaz-Rendelointezet es Baleseti Kozpont, Szemeszet KR
city: Budapest
country: Hungary
facility: Semmelweis Egyetem Szemészeti Vizsgálóhely
city: Budapest
country: Hungary
facility: Bajcsy-Zsilinszky Hospital
city: Budapest
country: Hungary
facility: Budapest Retina Associates Kft.
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Kozpont; Szemeszeti Klinika
city: Pécs
country: Hungary
facility: Ganglion Medial Center
city: Szeged
country: Hungary
facility: Szegedi Tudományegyetem ÁOK; Department of Ophtalmology
city: Szombathely
country: Hungary
facility: Markusovszky Egyetemi Oktatokorhaz ; SZEMESZET; Intezeti Gyogyszertar
city: Zalaegerszeg
country: Hungary
facility: Zala Megyei Kórház; SZEMESZET
city: Haifa
country: Israel
facility: Rambam Medical Center; Opthalmology
city: Jerusalem
country: Israel
facility: Hadassah MC; Ophtalmology
city: Petach Tikva
country: Israel
facility: Rabin MC; Ophtalmology
city: Rehovot
country: Israel
facility: Kaplan Medical Center; Ophtalmology
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky MC; Ophtalmology
city: Roma
country: Italy
facility: Fondazione G.B. Bietti Per Lo Studio E La Ricerca in Oftalmologia-Presidio Ospedaliero Britannico
state: Lazio
city: Genova
country: Italy
facility: UNIVERSITA' DEGLI STUDI DI GENOVA - Di.N.O.G.;CLINICA OCULISTICA
state: Liguria
city: Milano
country: Italy
facility: Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico-Clinica Regina Elena;U.O.C Oculistica
state: Lombardia
city: Milano
country: Italy
facility: Irccs Ospedale San Raffaele;U.O. Oculistica
state: Lombardia
city: Firenze
country: Italy
facility: Azienda Ospedaliero-Universitaria Careggi; S.O.D. Oculistica
state: Toscana
city: Pisa
country: Italy
facility: Nuovo Ospedale S. Chiara - A.O.U.P Presidio Ospedaliero di Cisanello; U.O. Oculistica Universitaria
state: Toscana
city: Perugia
country: Italy
facility: Azienda Ospedaliera di Perugia Ospedale S. Maria Della Misericordia; Clinica Oculistica
state: Umbria
city: Negrar Di Valpolicella (VR)
country: Italy
facility: Ospedale Classificato Equiparato Sacro Cuore ? Don Calabria; Presso Ufficio Cassa
state: Veneto
city: Aichi
country: Japan
facility: Sugita Eye Hospital
city: Aichi
country: Japan
facility: Nagoya University Hospital
city: Aichi
country: Japan
facility: Nagoya City University Hospital
city: Aichi
country: Japan
facility: Aichi Medical University Hospital
city: Chiba
country: Japan
facility: Toho University Sakura Medical Center
city: Fukuoka
country: Japan
facility: Hayashi Eye Hospital
city: Fukuoka
country: Japan
facility: Kurume University Hospital
city: Hokkaido
country: Japan
facility: Hokkaido University Hospital
city: Hokkaido
country: Japan
facility: Asahikawa Medical University Hospital
city: Hyogo
country: Japan
facility: Hyogo Prefectural Amagasaki General Medical Center (Hyogo AGMC)
city: Ibaraki
country: Japan
facility: Kozawa eye hospital and diabetes center
city: Kumamoto
country: Japan
facility: Ideta Eye Hospital
city: Kyoto
country: Japan
facility: Kyoto University Hospital
city: Mie
country: Japan
facility: Mie University Hospital
city: Miyazaki
country: Japan
facility: University of Miyazaki Hospital
city: Nara
country: Japan
facility: Nara Medical University Hospital
city: Osaka
country: Japan
facility: Kitano Hospital
city: Osaka
country: Japan
facility: Osaka Metropolitan University Hospital
city: Saitama
country: Japan
facility: National Defense Medical College Hospital
city: Shiga
country: Japan
facility: Shiga University Of Medical Science Hospital
city: Tokyo
country: Japan
facility: Tokyo Women's Medical University
city: Tokyo
country: Japan
facility: Kyorin University Hospital
city: Tokyo
country: Japan
facility: Tokyo Medical University Hachioji Medical Center
city: Seongnam-si
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Seoul
country: Korea, Republic of
facility: Kyung Hee University Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Del. Cuauhtemoc
country: Mexico
facility: Centro Oftalmológico Mira, S.C
state: Mexico CITY (federal District)
city: Mexico, D.F.
country: Mexico
facility: Macula Retina Consultores
state: Mexico CITY (federal District)
city: Mexico, D.F.
country: Mexico
facility: Hospital de la Ceguera APEC
state: Mexico CITY (federal District)
city: Querétaro
country: Mexico
facility: Instituto de la retina del Bajio
state: Queretaro
city: Lima
country: Peru
facility: Mácula D&T
city: Lima
country: Peru
facility: TG Laser Oftalmica
city: Lima
country: Peru
facility: Oftalmolaser
city: Bielsko-Biala
country: Poland
facility: Szpital sw. Lukasza
city: Bydgoszcz
country: Poland
facility: Specjalistyczny O?rodek Okulistyczny Oculomedica
city: Bydgoszcz
country: Poland
facility: OFTALMIKA Sp. z o.o
city: Bytom
country: Poland
facility: Szpital Specjalistyczny nr 1; Oddzial Okulistyki
city: Gda?sk
country: Poland
facility: Dobry Wzrok Sp Z O O
city: Gda?sk
country: Poland
facility: Optimum Profesorskie Centrum Okulistyki
city: Gliwice
country: Poland
facility: Poradnia Okulistyczna i Salon Optyczny w Gliwicach- PRYZMAT
city: Katowice
country: Poland
facility: Gabinet Okulistyczny Prof Edward Wylegala
city: Krakow
country: Poland
facility: Centrum Medyczne UNO-MED
city: Krakow
country: Poland
facility: SP ZOZ Szpital Uniwersytecki w Krakowie Oddzia? Kliniczny Okulistyki i Onkologii Okulistycznej
city: Rybnik
country: Poland
facility: Optomed Sp. z o.o.
city: Rzeszów
country: Poland
facility: Osrodek Chirurgii Oka prof. Zagorskiego Rzeszow
city: Rzeszów
country: Poland
facility: Kliniczny Szpital Wojewodzki nr 1 im. F. Chopina; Klinika Okulistyki
city: Tarnowskie Góry
country: Poland
facility: Caminomed
city: Warszawa
country: Poland
facility: Centrum Zdrowia MDM
city: Wroclaw
country: Poland
facility: SPEKTRUM Osrodek Okulistyki Klinicznej
city: Braga
country: Portugal
facility: Hospital de Braga; Servico de Oftalmologia
city: Coimbra
country: Portugal
facility: AIBILI - Association for Innovation and Biomedical Research on Light
city: Coimbra
country: Portugal
facility: Espaco Medico Coimbra
city: Lisboa
country: Portugal
facility: Hospital de Santa Maria; Servico de Oftalmologia
city: UFA
country: Russian Federation
facility: Clinic Optimed
state: Baskortostan
city: Cheboksary
country: Russian Federation
facility: Intersec Research and Technology Complex ?Eye Microsurgery? n.a. S.N. Fyodorov; Cheboksary Branch
state: Marij EL
city: Moscow
country: Russian Federation
facility: FSBI ?Scientific Research Institute of Eye Diseases? of Russian Academy of medical Sciences
state: Moskovskaja Oblast
city: St.Petersburg
country: Russian Federation
facility: Medical Military Academy n.a S.M.Kirov
state: Sankt Petersburg
city: Kazan
country: Russian Federation
facility: Clinics of Eye Diseases, LLC
state: Tatarstan
city: Irkutsk
country: Russian Federation
facility: ?Intersec. Research and Technology Complex ?Eye Microsurgery? n a Fyodorov Irkutsk branch
city: Novosibirsk
country: Russian Federation
facility: ?Intersec Research and Technology Complex Eye Microsurgery n a Fyodorov Novosibirsk Branch
city: Singapore
country: Singapore
facility: National University Hospital; Ophthalmology Department
city: Singapore
country: Singapore
facility: Singapore Eye Research Institute
city: Singapore
country: Singapore
facility: Tan Tock Seng Hospital; Ophthalmology Department
city: Trebišov
country: Slovakia
facility: Nemocnica s poliklinikou Trebišov, a.s.
city: Trencin
country: Slovakia
facility: Fakultna nemocnica Trencin Ocna klinika
city: Zilina
country: Slovakia
facility: Fakultna nemocnica s poliklinikou Zilina; Ocne oddelenie
city: Oviedo
country: Spain
facility: Instituto Oftalmologico Fernandez Vega; Servicio de oftalmologia
state: Asturias
city: Hospitalet de Llobregat
country: Spain
facility: Hospital Universitario de Bellvitge
state: Barcelona
city: San Cugat Del Valles
country: Spain
facility: Hospital General de Catalunya
state: Barcelona
city: Santiago de Compostela
country: Spain
facility: Instituto Oftalmologico Gomez Ulla; Servicio de Oftalmologia
state: LA Coruña
city: Las Palmas de Gran Canaria
country: Spain
facility: Hospital Universitario de Gran Canaria; Servicio de oftalmologia
state: LAS Palmas
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro
state: Madrid
city: Pamplona
country: Spain
facility: Clinica Universitaria de Navarra; Servicio de Oftalmologia
state: Navarra
city: Pamplona
country: Spain
facility: Complejo Hospitalario de Navarra; Servicio de oftalmologia
state: Navarra
city: Burjassot
country: Spain
facility: Oftalvist Valencia
state: Valencia
city: Albacete
country: Spain
facility: Complejo Hospitalario Universitario Albacete; Servicio de oftalmologia
city: Alicante
country: Spain
facility: VISSUM Instituto Oftalmológico de Alicante
city: Barcelona
country: Spain
facility: Centro de Oftalmologia Barraquer; Servicio Oftalmologia
city: Barcelona
country: Spain
facility: Hospital dos de maig; servicio de oftalmologia
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona; Consultas Externas Oftalmologia
city: Barcelona
country: Spain
facility: Hospital de Santa Creu I Sant Pau; Servicio de Oftalmologia
city: Madrid
country: Spain
facility: Clinica Baviera; Servicio Oftalmologia
city: Valencia
country: Spain
facility: Fisabio-Ofalmologia Medica; Servicio de Oftalmología
city: Valladolid
country: Spain
facility: Hospital Universitario Rio Hortega; Servicio de Oftalmologia
city: Binningen
country: Switzerland
facility: Vista Klinik Ophthalmologische Klinik
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital; Ophthalmology
city: Taoyuan
country: Taiwan
facility: Chang Gung Medical Foundation - Linkou; Ophthalmology
city: Zhongzheng Dist.
country: Taiwan
facility: National Taiwan University Hospital; Ophthalmology
city: Bangkok
country: Thailand
facility: King Chulalongkorn Memorial Hospital; Ophthalmology Department
city: Bangkok
country: Thailand
facility: Rajavithi Hospital; Ophthalmology Department
city: ChiangMai
country: Thailand
facility: Maharaj Nakorn ChiangMai Hospital; Ophthalmology Department
city: Ankara
country: Turkey
facility: Hacettepe University Medical Faculty; Department of Ophthalmology
city: Ankara
country: Turkey
facility: Ankara University Medical Faculty; Department of Ophthalmology
city: Ankara
country: Turkey
facility: Ankara Baskent University Medical Faculty; Department of Ophthalmology
city: Istanbul
country: Turkey
facility: Beyoglu Goz Training and Research Hospital; Department Of Ophthalmology
city: Izmir
country: Turkey
facility: Ege University Medical Faculty; Department of Ophthalmology
city: Kocaeli
country: Turkey
facility: Kocaeli Üniversitesi T?p Fakültesi; Department of Ophthalmology
city: Konya
country: Turkey
facility: Selcuk University Faculty of Medicine; Department Of Ophthalmology
city: Belfast
country: United Kingdom
facility: Belfast Health and Social Care Trust, ROYAL VICTORIA HOSPITAL
city: Bradford
country: United Kingdom
facility: Bradford Royal Infirmary
city: Canterbury
country: United Kingdom
facility: East Kent Hospitals University NHS Foundation Trust
city: Frimley
country: United Kingdom
facility: Frimley Park Hospital
city: Gloucestershire
country: United Kingdom
facility: Gloucestershire Hospitals NHS Foundation Trust
city: Leeds
country: United Kingdom
facility: St James University Hospital
city: Liverpool
country: United Kingdom
facility: Royal Liverpool University Hospital; St Paul's Clinical Eye Research Centre
city: London
country: United Kingdom
facility: Moorfields Eye Hospital NHS Foundation Trust
city: London
country: United Kingdom
facility: Royal Free Hospital
city: London
country: United Kingdom
facility: Kings College Hospital
city: Manchester
country: United Kingdom
facility: Manchester Royal Eye Hospital
city: Middx
country: United Kingdom
facility: Hillingdon Hospital
city: Newcastle upon Tyne
country: United Kingdom
facility: Royal Victoria Infirmary
city: Norfolk
country: United Kingdom
facility: James Paget University Hospitals NHS Foundation Trust
city: Southampton
country: United Kingdom
facility: University Hospital Southampton NHS Foundation Trust; Southampton Eye Unit
city: Sunderland
country: United Kingdom
facility: Sunderland Eye Infirmary
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
References: