Clinical trial NCT04941326: The Effect of Spinal Mobilization on Respiratory Parameters in Parkinson's Disease Patients
Official title: Investigation of the Effect of Spinal Mobilization and Respiration Techniques on Posture and Respiratory Function in Parkinson's Patients
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Parkinson Disease
Camptocormia
Restrictive Lung Disease
Keywords: Rehabilitation
Posture
Lead sponsor: Abant Izzet Baysal University
Sponsor class: OTHER
First posted: 2021-06-28
Enrollment: 63
Sex: ALL
Minimum age (years): 50
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Two groups with sham control group
Primary purpose: TREATMENT

Brief summary: Parkinson's patients suffer from respiratory distress for different reasons. It is thought that physiotherapy methods that have an indirect effect on the diaphragm can improve respiratory functions. The aim of this study is to investigate the effects of spinal mobilization and diaphragmatic breathing techniques on respiratory function.

Detailed description: Respiratory complications are one of the most common causes of death in Parkinson's patients. Camptocormia may develop in Parkinson's disease and other pathological conditions involving the basal ganglia, which can be defined as an abnormal flexion of the thoracolumbar spine of 45° or more, which increases during walking or standing and disappears completely in the supine position. Parkinson's patients with camptocormia often complain of dyspnea, which can be attributed to reduced lung capacity due to limited chest expansion.

Restrictive changes due to respiratory muscle dysfunction in Parkinson's disease, upper airway obstruction, abnormal ventilatory control, and drug use such as levodopa have an effect on respiratory functions.

Restrictive dysfunction has been reported in 28-94% of patients with Parkinson's.

Postural disorders such as camptocormia can also lead to restriction. One study found that the lung volumes of Parkinson's disease patients with camptocormia decreased, although it was not associated with major clinical changes.

Diaphragmatic dyskinesia in Parkinson's patients may also lead to a restrictive deterioration in respiratory functions.

Studies examining the effects of chest and diaphragm mobilization on spirometric parameters in patients with cerebral palsy reported that the applied mobilization and soft tissue techniques improved FEV1 and FVC. The effect of indirect diaphragmatic treatments with vertebral mobilization in individuals with Parkinson's who are at risk of experiencing restrictive respiratory problems is unknown. The aim of this study is to examine the effects of spinal mobilization techniques for the diaphragm on respiratory function parameters and posture.

Eligibility criteria: Inclusion Criteria:

* Have been diagnosed with Parkinson's disease
* Volunteering to participate in the study
* Modified Medical Research Council (MMRC) score \>2

Exclusion Criteria:

* Those with COVID-19
* Diseases that increase intra-abdominal pressure
* Diseases affecting diaphragmatic motility
* Those who had a recent thoracic or abdominal operation
* Those who have a parenchymal, pleural or chest wall mass that will cause restriction on a recent chest X-ray or CT will not be included in the study

Primary outcomes:
measure: Pulmonary Function Test
timeFrame: Four weeks
Secondary outcomes:
measure: Spinal Mouse Evaluation
timeFrame: Four weeks
measure: Camptocormia and Range of Motion Evaluations
timeFrame: Four weeks
measure: Ultrasonography
timeFrame: Four weeks
Other outcomes:
Locations:
city: Bolu
country: Turkey
facility: Abant Izzet Baysal University Faculty of Health Science
city: Bolu
country: Turkey
facility: AIBU Physical Therapy and Rehabiltiation Department
Study officials:
affiliation: Abant Izzet Baysal University
name: Ramazan Kurul, Ph.D
role: PRINCIPAL_INVESTIGATOR
References: