louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05333094: Comparison Between the Effectiveness of Different Commercial Bracket Brands
Official title: Comparison Between the Effectiveness of Different Commercial Bracket Brands, Having Roth Prescription and 0.022" Bracket Slot: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Crowding, Tooth, Class I
Keywords: orthodontic bracket brands
torque prescription
tip prescription
levelling and Alignment
Lateral Cephalometric Radiographs
CBCT
VAS
Lead sponsor: Future University in Egypt
Sponsor class: OTHER
First posted: 2022-04-18
Enrollment: 30
Sex: ALL
Minimum age (years): 14
Maximum age (years): 19
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: There's a scarcity in literature concerning the comparison of the effectiveness of brackets in its torque and tip ability, the time takes for leveling and alignment comparing between different orthodontic bracket brands, and its effect on the rate of tooth movement. The purpose of this study is to determine, In orthodontic patients with Class I molar relation and teeth crowding, in which different bracket brands will be compared.

Detailed description: Bracket effectiveness can be measured in a variety of ways, including torque, tip, time required for levelling and alignment, bracket failure, and the patient's visual analogue scale. All are viable options; therefore, we want to complete the orthodontic treatment and determine which brackets fulfilled the built-in bracket prescription and achieved success in terms of aesthetics, better smiles, better patient judgement, and function.

Eligibility criteria: Inclusion Criteria:

* Patient with full set of permanent teeth
* Male and female (14-19 years old).
* Positive patients' acceptance for the study
* Patients have no history of previous orthodontic treatment.

Exclusion Criteria:

* Patients with enamel or dentin defect or any teeth anomaly will be eliminated.
* Patients having canine or lateral incisors peg shaped will be excluded from the research. - Medically compromised patients
* Patients unable to give an informed consent
* Patient with periodontal disease
* Patient taking long term medication
* Patients with any parafunctional habits (i.e. Bruxism, tongue thrusting, mouth Breathing)

Primary outcomes:
measure: Tip
timeFrame: From pre to post levelling and alignment (an average of 6 - 8 months)
measure: torque
timeFrame: 3 months after reaching 19x25 stainless steel wire (an average of 6 - 8 months)
Secondary outcomes:
measure: Levelling and alignment
timeFrame: upto 6 months from the start of orthodontic treatment.
Other outcomes:
measure: Pain of intervention
timeFrame: From pre to post levelling and alignment (an average of 6 - 8 months)
Locations:
city: Cairo
country: Egypt
facility: Future University In Egypt
Study officials:
affiliation: Future University in Egypt
name: Yehya A. Mostafa, Professor and Chairman
role: STUDY_DIRECTOR
References:
Clinical trial NCT02998294: Respiratory Volume Measure Using ExSpiron 1Xi
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: ICU(Intensive Care Unit) Patients
Mechanical Ventilation After Surgery
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2016-12-20
Enrollment: 63
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study was to determine the accuracy of one-time respiratory volume measured by RVM(Respiratory Volume Monitor) compared to the one-time respiratory volume measured by mechanical ventilation in post-operative ICU patients.

Detailed description: The purpose of this study was to determine the accuracy of one-time respiratory volume measured by RVM(Respiratory Volume Monitor) compared to the one-time respiratory volume measured by mechanical ventilation in post-operative ICU patients.

In addition, the investigators investigated the decrease in respiratory volume in opioid infusion after ventilator weaning in this patient, and to measure the one-time respiratory volume change by RVM during deep breathing induction using Inspirometry exercise.

Eligibility criteria: Inclusion Criteria:

* An adult patients ( ≥ age 19)
* patients who receive mechanical ventilation in the ICU of the Severance Hospital after surgery and plans to wean the mechanical ventilation within 3 days.

Exclusion Criteria:

* severe respiratory illness patients (pneumothorax, chest tube intubation status, severe restrictive respiratory disease, unilateral lung ventilation, lung transplantation status, chronic restrictive respiratory disease, hydrothorax, diaphragmatic movement disorder)
* If the candidate can not understand and carry out the experiment contents and process

Primary outcomes:
measure: Respiratory volume measure using ExSpiron 1Xi
timeFrame: during 10-minute
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine
Study officials:
References:
Clinical trial NCT01464294: Clinical Evaluation of Chairside CAD/CAM Nano-ceramic Restorations
Official title: Clinical Evaluation of Chairside CAD/CAM Nano-ceramic Restorations
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Restoration of Posterior Teeth
Keywords: CAD/CAM
crowns
onlays
composite block
milled restorations
Lead sponsor: Solventum US LLC
Sponsor class: INDUSTRY
Collaborators: name: 3M
First posted: 2011-11-03
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients attending and/or under clinical treatment at the University of Michigan Dental Clinics

Brief summary: Study aim is to test whether nano-composite CAD/CAM milled restorations have a similar performance in clinical service to conventional ceramic CAD/CAM restorations.


Eligibility criteria: Inclusion Criteria:

* Patient 18 years of age or over
* To have at least one carious lesion or defective restoration in a molar or premolar tooth, cavities to be large enough to warrant a milled restoration of either a crown or onlay
* Teeth to be vital and asymptomatic

Exclusion Criteria:

* Devital or sensitive teeth
* Teeth that have had root canal treatment
* Patients with significant untreated dental disease including periodontitis and rampant caries
* Pregnant or lactating women

Primary outcomes:
measure: clinical performance
timeFrame: 3 years
Secondary outcomes:
measure: Luting cement
timeFrame: 3 years
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: School of Dentistry, Unversity of Michigan
state: Michigan
Study officials:
affiliation: School of Dentistry, Univ of Michigan
name: Dennis Fasbinder, DDS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01039194: Drug-Drug Interaction to Study the Effect of BMS-708163 on Pharmacokinetics (PK) of Galantamine Extended Release (ER)
Official title: A Study of the Effect of Concomitant Administration of Multiple Doses of BMS-708163 on the Pharmacokinetics of Galantamine in Healthy Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Alzheimer Disease
Lead sponsor: Bristol-Myers Squibb
Sponsor class: INDUSTRY
First posted: 2009-12-24
Enrollment: 18
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: The purpose of the study is to find out if the plasma concentration of galantamine extended release is changed when BMS-708163 is administered at the same time.


Eligibility criteria: Inclusion Criteria:

* Healthy men and postmenopausal women

Exclusion Criteria:

* Gastrointestinal disorders
* Bleeding disorders
* Peptic ulcer disease
* Cholecystectomy
* Seizure disorder
* Asthma
* Chronic obstructive pulmonary disease
* Urinary tract obstruction
* Cardiac conduction abnormalities, including but not limited to "sick sinus syndrome" and those with unexplained syncopal episodes
* Inability to tolerate oral medication
* Inability to be venipunctured and/or tolerate venous access

Primary outcomes:
measure: Galantamine alone and with BMS-708163: Galantamine PK parameters (Cmax, Tmax, AUC(TAU) and Ctrough rations will be assessed without BMS-708163 Day 14) and with BMS708-163 (Ctrough Day 24)
timeFrame: Study Days 14 & 24
Secondary outcomes:
measure: Galantamine alone and with BMS 708163: Safety and tolerability (AE's, ECG, vital signs, safety labs)
timeFrame: Study Days 7, 14, 18, 25 and study discharge
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: Parexel International - Baltimore Epcu
state: Maryland
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References:
Clinical trial NCT06444594: Transient Receptor Potential Channels
Official title: Transient Receptor Potential Channels in Human Skin
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: EARLY_PHASE1
Conditions: Aging
Lead sponsor: Penn State University
Sponsor class: OTHER
First posted: 2024-06-05
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.


Eligibility criteria: Inclusion Criteria:

* 18-85 years old.
* Women will not be pregnant and/or breastfeeding.

Exclusion Criteria:

* Currently pregnant or breastfeeding
* Nicotine use (e.g., smoking, chewing tobacco etc.), quantified as more than 100 cigarettes or cigars in a lifetime)
* Known skin allergies or current rash, skin disease, disorders of pigmentation
* Diabetes
* Body mass index \>35kg\*m-2
* Using calcium channel blockers
* Raynaud's syndrome
* Allergy or hypersensitivity to menthol, camphor, capsaicin or adhesive
* Regular use (defined as greater than once a week) of topical analgesics that contain menthol, camphor or capsaicin

Primary outcomes:
measure: Skin blood flow during slow local heating
timeFrame: 75 minutes
measure: Somatosensory perception
timeFrame: every 5 minutes for 120 minues
measure: algometer measurement
timeFrame: every 30 minutes for 120 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: University Park
country: United States
facility: Noll Laboratory
state: Pennsylvania
Study officials:
affiliation: Penn State University
name: Lacy Alexander, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03763994: Reliability of an Objective Measurement to Assess Lumbar Spine Motion in Healthy Controls and in Low Back Pain Patients
Official title: Reliability of an Objective Measurement to Assess Lumbar Spine Motion in Healthy Controls and in Low Back Pain Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Reliability, Validity of Measurement to Assess Lumbar Spine Motion
Comparison of Healthy Subjects and Low Back Pain Patients
Lead sponsor: Ruhr University of Bochum
Sponsor class: OTHER
First posted: 2018-12-04
Enrollment: 102
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Low back pain patients were recruited among in-and outpatients of the Department of Pain Medicine at the Bergmannsheil, Bochum. The subjects of the control groups were recruited by distributing flyers in sport groups and among hospital staff and friends.

Brief summary: Main of the study is to assess the reliability of a new objective tool to measure lumbar spine motion. The data will be collected from healthy subjects and subjects with frequent or daily low back pain in the last three months. In addition we compare the results of the motion measurements with disability and pain questionnaires such as the Roland Morris, Oswestry Disability Index and the Brief Pain Inventory.


Eligibility criteria: Inclusion Criteria:

* older than 18 years, informed consent, sufficient German skills \<30 days low back pain in the last 90 days (control group) \>31days of low back pain in the last 90 days (low back pain group)

Exclusion Criteria:

* neurological disorder (including multiple sclerosis, Stroke, Parkinson´s disease), Current pain \>= 4 (NSR)/intake of analgesic in the last 24h/ previous low back surgery (control group), inability to perform choreography (LBP group)

Primary outcomes:
measure: reliability of measurement tool
timeFrame: February 2012-February 2013
Secondary outcomes:
Other outcomes:
Locations:
city: Bochum
country: Germany
facility: Berufsgenossenschaftliches Universitätklinikum Bergmannsheil
state: Northrine-Westfalia
Study officials:
References:
Clinical trial NCT02673294: Chronicity Dependence of a Balance Training in Adults Post-stroke
Official title: Chronicity Dependence of a Balance Training in Adults Post-stroke
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke, Postural Balance, Virtual Rehabilitation
Lead sponsor: Hospitales Nisa
Sponsor class: OTHER
Collaborators: name: Universitat Politècnica de València
First posted: 2016-02-03
Enrollment: 47
Sex: ALL
Minimum age (years): 50
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The level of stroke chronicity has been proposed as an influential variable related to functional balance. However, little is known about the effect of this variable on the effectiveness and maintenance of gains of physical therapy interventions on balance. The objective of this study is to determine the influence of time since injury on the rehabilitation of balance after stroke. Participants will be assigned to a least (6-12 months), a moderate (12-24 months), or a most chronic (\> 24 months) group. All the participants will train for 20 one-hour sessions, administered three to five times a week, combining conventional physical therapy exercises and customized exercises interfaced on a balance board that promotes the training of the ankle and hip strategies. Participants will be assessed before, after the intervention, and one month later with a posturography test (sway speed and limits of stability) and clinical scales (Berg Balance Scale, Functional Reaches Test, 30-Second Sit-to-Stand Test, Timed Up and Down Stairs Test, Stepping Test, Timed Up-and-Go Test, and the 10-meter Walking Test).


Eligibility criteria: Inclusion Criteria:

* Age ≥ 50 and ≤ 65 years old
* Chronicity \> six months
* Fairly good cognitive condition defined by scores in the Mini-Mental State Examination above 23
* Ability to walk 10 meters indoors with or without technical orthopaedic aids.

Exclusion Criteria:

* Impaired comprehension that hinder sufficient understanding of the instructions defined by Mississippi Aphasia Screening Test scores below 45
* Unilateral spatial neglect
* Ataxia or any other cerebellar symptom
* Severe auditory or visual impairments
* Motional or behavioural circumstances that impede adequate collaboration.

Primary outcomes:
measure: Balance Berg Scale
timeFrame: up to 1-month follow-up
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01630694: Three-dimensional Craniofacial Phenotyping of Patients With Difficult Airway
Official title: Three -Dimensional (3-D) Craniofacial Phenotyping of Patients With Difficult Airway
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Failed or Difficult Intubation
Keywords: Difficult airway management
anesthesia
difficult intubation
Lead sponsor: University of Rochester
Sponsor class: OTHER
First posted: 2012-06-28
Enrollment: 28
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to identify differences in craniofacial morphology and tongue size between patients who have a history of difficult airway management and a control group of patients who had an uneventful airway management during induction of general anesthesia. In this study the investigators want to validate the hypothesis that there are craniofacial phenotypic differences between patients who have a history of difficult airway management and a control group of patients who have had an uneventful airway management during the induction of general anesthesia.

Detailed description: Difficult airway management is one of the most challenging tasks for anesthesiologists. Recent data from the American Society of Anesthesiologists (ASA) Management Closed Claims Project \[1\] show that the percentage of claims resulting from adverse respiratory events, though on the decline (42% in the 1980s to 32% in the 1990s), continue to constitute a large source of morbidity and mortality in anesthetized patients. In 2005, a closed claims analysis of trends in anesthesia-related death and brain damage between 1975 and 2000 showed that out of all respiratory events (n=503) responsible for death and brain damage, difficult endotracheal intubation (n=115), inadequate oxygenation (n=111) and inadvertent esophageal intubation (n=66) were the top three causes \[2\].

Eligibility criteria: Inclusion Criteria:

* patients that had undergone or will undergo a surgery under general anesthesia .

Exclusion Criteria:

* known history of syndromal craniofacial abnormalities (e.g. Down syndrome)
* previous craniofacial surgery
* excessive facial hair which significantly obscure facial landmarks
* cervical spine fractures
* tracheostomy tube
* patients who are unable to give consent

Primary outcomes:
measure: Mean Hyomental Distance Ratio
timeFrame: end of study approximately one year
Secondary outcomes:
measure: Mean Tongue Volume
timeFrame: end of study approximately one year
Other outcomes:
Locations:
city: Rochester
country: United States
facility: University of Rochester Medical Center
state: New York
Study officials:
affiliation: University of Rochester
name: Jacek Wojtczak, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00168194: Cellular Immune Responses to Hepatitis B Virus (HBV)- Longitudinal Follow up and Natural History
Official title: Cellular Immune Responses to Hepatitis B Virus (HBV)- Longitudinal Follow up and Natural History
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hepatitis B
HIV Infections
Keywords: HIV
Lead sponsor: The Alfred
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
First posted: 2005-09-15
Enrollment: 104
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: HIV and hepatitis B co-infection

Brief summary: It remains unclear why some individuals are able to clear HBV from their bodies while in others HBV is a persistent infection. We plan to investigate this process by collecting blood and analysing how the patient's white blood cells respond to different pieces of the HBV virus. We will use new tools that can precisely tell us which component of the immune response may be different in individuals who are chronically infected with HBV and also in individuals who are also infected with HIV.

The primary aims are therefore:

1. To characterize HBV-specific T cell responses in HBV chronic carriers, and identify novel immunogenic regions in both HLA-A2+ and non-HLA-A2+ individuals.
2. To determine the effect of HIV infection on HBV-specific T-cell responses


Eligibility criteria: Inclusion Criteria:

There are two groups of patients in this study. Group A mono-infected with Hepatitis B, and those with co-infection HBV/HIV.

Group A inclusion criteria: (also split into 6 recruiting groups)

* Acute hepatitis B
* Chronic hepatitis B, HBV DNA+ve , normal ALT , HBeAg +ve
* Chronic hepatitis B, HBV DNA +ve , normal ALT, HBeAg -ve
* Chronic hepatitis , HBV DNA +ve, increased ALT, no HBV treatment B, HBeAg +ve
* Chronic hepatitis B, HBV DNA +ve , increased ALT, no HBV treatment B, HBeAg -ve
* Chronic hepatitis B, undergoing 'flare' of hepatitis

Group B inclusion criteria:

* To be HIV/HBV co-infected

All patients:

* To be over 18 years

Exclusion Criteria:

* Those who do not fit the inclusion criteria.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Melbourne
country: Australia
facility: The Alfred Hospital, Commercial Road
state: Victoria
Study officials:
affiliation: Burnet Institute, Melbourne
name: Sharon Lewin, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02701894: ALA on Glycemic Control in T2DM Participants
Official title: The Effect of Alpha-Linolenic Acid on Glycemic Control in Participants With Type 2 Diabetes
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Lead sponsor: Unity Health Toronto
Sponsor class: OTHER
First posted: 2016-03-08
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Participants with type 2 diabetes mellitus.

Brief summary: With the emerging worldwide epidemic of type 2 diabetes, dietary recommendations to improve diabetes management have been emphasized in the scientific community. Particular attention has been drawn to various benefits of replacing saturated fatty acids with unsaturated fatty acids. Alpha-linolenic acid, the only omega-3 fatty acid that is from plant sources, has been suggested by animal and cell studies to play a beneficial role in regulating blood glucose levels. However, human studies have been more inconsistent with their findings. The focus of this project is to investigate the evidence in the context of ALA and blood glucose parameters in participants with type 2 diabetes by conducting a systematic review and meta-analysis of randomized controlled trials.


Eligibility criteria: Inclusion Criteria:

* Controlled, randomized, clinical trials
* Trials greater than one month
* Focusing on ALA and T2DM participants
* Viable endpoint data

Exclusion Criteria:

* Non-human studies
* Non-random treatment allocation
* Less than 1 month
* Lack of suitable control
* Lack of endpoint data

Primary outcomes:
measure: HbA1c
timeFrame: 1 month
Secondary outcomes:
measure: Fructosamine
timeFrame: 1 month
measure: Fasting Blood Glucose
timeFrame: 1 month
measure: Fasting Blood Insulin
timeFrame: 1 month
measure: Glycated Albumin
timeFrame: 1 month
measure: HOMA- IR
timeFrame: 1 month
Other outcomes:
Locations:
Study officials:
affiliation: Unity Health Toronto
name: Vladimir Vuksan, PhD
role: PRINCIPAL_INVESTIGATOR
References: