Clinical trial NCT00391872: A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome
Official title: A Randomised, Double-blind, Parallel Group, Phase 3, Efficacy and Safety Study of Ticagrelor Compared With Clopidogrel for Prevention of Vascular Events in Patients With Non-ST or ST Elevation Acute Coronary Syndromes (ACS) [PLATO- a Study of PLATelet Inhibition and Patient Outcomes]
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Acute Coronary Syndrome
Keywords: ACS
Acute coronary syndrome
Heart attack
Unstable angina
Coronary artery disease
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2006-10-25
Enrollment: 18624
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Ticagrelor is a new, reversible binding, anti-platelet medication. Anti-platelet medications work to prevent the formation of blood clots. Ticagrelor is being developed as a treatment for patients with acute coronary syndrome (ACS). ACS is a term that is used to describe both heart attacks in progress or the imminent threat of a heart attack. ACS is usually caused by the formation of a blood clot in an artery that partially or totally blocks the blood supply to a portion of the heart muscle. Ticagrelor will be compared with clopidogrel to determine which drug, when either is used in conjunction with aspirin, is better at reducing deaths from vascular causes, future heart attacks and/or strokes in patients with ACS.


Eligibility criteria: Inclusion Criteria:

* Male or female 18 years or older who has been hospitalised for chest pain and potential ACS
* Females of child-bearing potential must have a negative pregnancy test at enrollment and be willing to use 2 methods of reliable contraception

Exclusion Criteria:

* Persons with moderate or severe liver disease
* Persons who have already been treated with an invasive (angioplasty) procedure for the current episode of ACS
* Persons who are being treated with blood clotting agents that cannot be stopped

Primary outcomes:
measure: Participants With Any Event From the Composite of Death From Vascular Causes, Myocardial Infarction (MI), and Stroke
timeFrame: Randomization up to 12 months
measure: Participants With Any Major Bleeding Event
timeFrame: First dosing up to 12 months
Secondary outcomes:
measure: Participants With Any Event From the Composite of Death From Vascular Causes, MI, and Stroke for the Subgroup of Patients With Intent for Invasive Management at Randomization
timeFrame: Randomization up to 12 months
measure: Participants With Any Event From the Composite of All-cause Mortality, MI, and Stroke
timeFrame: Randomization up to 12 months
measure: Participants With Any Event From the Composite of Death From Vascular Causes, MI (Including Silent), Stroke, Recurrent Ischemia, Transient Ischemic Attack (TIA) and Other Arterial Thrombotic Events.
timeFrame: Randomization up to 12 months
measure: Participants With MI Event
timeFrame: Randomization up to 12 months
measure: Participants With Death From Vascular Causes
timeFrame: Randomization up to 12 months
measure: Participants With Stroke
timeFrame: Randomization up to 12 months
measure: Participants With Death From Any Cause
timeFrame: Randomization up to 12 months
measure: Participants With Non-CABG (Coronary Artery Bypass Graft) Related Major Bleeding
timeFrame: First dosing up to 12 months
measure: Participants With Major or Minor Bleeding
timeFrame: First dosing up to 12 months
measure: Participants With Non-procedural Major Bleeding
timeFrame: First dosing up to 12 months
measure: Participants With Coronary Artery Bypass Graft (CABG) Major Bleeding
timeFrame: First dosing up to 12 months
measure: Participants With Coronary Artery Bypass Graft (CABG) Major Fatal/Life-threatening Bleeding
timeFrame: First dosing up to 12 months
measure: Participants With Ventricular Pauses of Greater Than or Equal to 3 Seconds in Patients Monitored by Holter 24-hour ECG Recorders for 1 Week Following Randomization
timeFrame: 1-week period following randomization
measure: Participants With Ventricular Pauses of Greater Than or Equal to 3 Seconds in Patients Monitored by Holter 24 Hour ECG Recorders for 1 Week at 1 Month Following Randomization
timeFrame: 1-week period following randomization
Other outcomes:
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city: Aracaju
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city: S.j.rio Preto
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country: Czech Republic
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country: Denmark
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country: France
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country: France
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country: France
facility: Research Site
city: Paris
country: France
facility: Research Site
city: PAU
country: France
facility: Research Site
city: Pessac
country: France
facility: Research Site
city: Quincy Sous Senart
country: France
facility: Research Site
city: Rennes
country: France
facility: Research Site
city: Rouen
country: France
facility: Research Site
city: Senlis
country: France
facility: Research Site
city: Strasbourg
country: France
facility: Research Site
city: Toulouse
country: France
facility: Research Site
city: Tourcoing
country: France
facility: Research Site
city: Valenciennes
country: France
facility: Research Site
city: Tbilisi
country: Georgia
facility: Research Site
city: Aschaffenburg
country: Germany
facility: Research Site
city: Bad Mergentheim
country: Germany
facility: Research Site
city: Bad Nauheim
country: Germany
facility: Research Site
city: Bad Rothenfelde
country: Germany
facility: Research Site
city: Berlin
country: Germany
facility: Research Site
city: Bochum
country: Germany
facility: Research Site
city: Bonn
country: Germany
facility: Research Site
city: Cloppenburg
country: Germany
facility: Research Site
city: Coburg
country: Germany
facility: Research Site
city: Dortmund
country: Germany
facility: Research Site
city: Dresden
country: Germany
facility: Research Site
city: Duisburg
country: Germany
facility: Research Site
city: Erfurt
country: Germany
facility: Research Site
city: Essen
country: Germany
facility: Research Site
city: Esslingen
country: Germany
facility: Research Site
city: Frankfurt
country: Germany
facility: Research Site
city: Gottingen
country: Germany
facility: Research Site
city: Greifswald
country: Germany
facility: Research Site
city: Halle
country: Germany
facility: Research Site
city: Hamburg
country: Germany
facility: Research Site
city: Hannover
country: Germany
facility: Research Site
city: Heidelberg
country: Germany
facility: Research Site
city: Jena
country: Germany
facility: Research Site
city: Kiel
country: Germany
facility: Research Site
city: Krefeld
country: Germany
facility: Research Site
city: Limburg
country: Germany
facility: Research Site
city: Lubeck
country: Germany
facility: Research Site
city: Mainz
country: Germany
facility: Research Site
city: Merseburg
country: Germany
facility: Research Site
city: Monchengladbach
country: Germany
facility: Research Site
city: Muhlheim An Der Ruhr
country: Germany
facility: Research Site
city: Munster
country: Germany
facility: Research Site
city: Regensburg
country: Germany
facility: Research Site
city: Rostock
country: Germany
facility: Research Site
city: ULM
country: Germany
facility: Research Site
city: Warendorf
country: Germany
facility: Research Site
city: Witten
country: Germany
facility: Research Site
city: Wuppertal
country: Germany
facility: Research Site
city: Wurzburg
country: Germany
facility: Research Site
city: Heraklion
country: Greece
facility: Research Site
state: Crete
city: Athens
country: Greece
facility: Research Site
city: Larissa
country: Greece
facility: Research Site
city: Patra
country: Greece
facility: Research Site
city: Piraeus
country: Greece
facility: Research Site
city: Thessaloniki
country: Greece
facility: Research Site
city: Hong Kong
country: Hong Kong
facility: Research Site
city: Budapest
country: Hungary
facility: Research Site
city: Cegled
country: Hungary
facility: Research Site
city: Debrecen
country: Hungary
facility: Research Site
city: Gyula
country: Hungary
facility: Research Site
city: Hodmez-vasarhely
country: Hungary
facility: Research Site
city: Kaposvar
country: Hungary
facility: Research Site
city: Kecskemet
country: Hungary
facility: Research Site
city: Mosonmagyarovar
country: Hungary
facility: Research Site
city: Pecs
country: Hungary
facility: Research Site
city: Szekesfehervar
country: Hungary
facility: Research Site
city: Zalaegerszeg
country: Hungary
facility: Research Site
city: Hyderabad
country: India
facility: Research Site
state: Andhrapradesh
city: Vijayawada
country: India
facility: Research Site
state: Andhrapradesh
city: New Delhi
country: India
facility: Research Site
state: Delhi
city: Ahmedabad
country: India
facility: Research Site
state: Gujarat
city: Gandhinagar
country: India
facility: Research Site
state: Gujarat
city: Vadodara
country: India
facility: Research Site
state: Gujarat
city: Bangalore
country: India
facility: Research Site
state: Karnataka
city: Kochi
country: India
facility: Research Site
state: Kerala
city: Thrissur
country: India
facility: Research Site
state: Kerala
city: Bhopal
country: India
facility: Research Site
state: Madhya Pradesh
city: Mumbai
country: India
facility: Research Site
state: Maharashtra
city: Nagpur
country: India
facility: Research Site
state: Maharashtra
city: Patiala
country: India
facility: Research Site
state: Punjab
city: Bikaner
country: India
facility: Research Site
state: Rajasthan
city: Jaipur
country: India
facility: Research Site
state: Rajasthan
city: Chennai
country: India
facility: Research Site
state: Tamilnadu
city: Coimabatore
country: India
facility: Research Site
state: Tamilnadu
city: Kolkata
country: India
facility: Research Site
state: West Bengal
city: Denpasar
country: Indonesia
facility: Research Site
state: Bali
city: Bandung
country: Indonesia
facility: Research Site
state: Jawa Barat
city: Surabaya
country: Indonesia
facility: Research Site
state: Jawa Timur
city: Jakarta
country: Indonesia
facility: Research Site
city: Makassar
country: Indonesia
facility: Research Site
city: Semarang
country: Indonesia
facility: Research Site
city: Afula
country: Israel
facility: Research Site
city: Ashkelon
country: Israel
facility: Research Site
city: Beer Sheva
country: Israel
facility: Research Site
city: Hadera
country: Israel
facility: Research Site
city: Haifa
country: Israel
facility: Research Site
city: Holon
country: Israel
facility: Research Site
city: Jerusalem
country: Israel
facility: Research Site
city: Poriya M.p. Lower Galilee
country: Israel
facility: Research Site
city: Rehovot
country: Israel
facility: Research Site
city: Tel Aviv
country: Israel
facility: Research Site
city: Zerifin
country: Israel
facility: Research Site
city: Ancona
country: Italy
facility: Research Site
state: AN
city: Bari
country: Italy
facility: Research Site
state: BA
city: Bergamo
country: Italy
facility: Research Site
state: BG
city: Caserta
country: Italy
facility: Research Site
state: CE
city: Catania
country: Italy
facility: Research Site
state: CT
city: Ferrara
country: Italy
facility: Research Site
state: FE
city: Foggia
country: Italy
facility: Research Site
state: FG
city: San Giovanni Rotondo
country: Italy
facility: Research Site
state: FG
city: Bagno A Ripoli
country: Italy
facility: Research Site
state: FI
city: Firenze
country: Italy
facility: Research Site
state: FI
city: Legnano
country: Italy
facility: Research Site
state: MI
city: Milano
country: Italy
facility: Research Site
state: MI
city: Monza
country: Italy
facility: Research Site
state: MI
city: Rozzano
country: Italy
facility: Research Site
state: MI
city: Mantova
country: Italy
facility: Research Site
state: MN
city: Modena
country: Italy
facility: Research Site
state: MO
city: Pescara
country: Italy
facility: Research Site
state: PE
city: Parma
country: Italy
facility: Research Site
state: PR
city: Pavia
country: Italy
facility: Research Site
state: PV
city: Ostia Lido
country: Italy
facility: Research Site
state: Roma
city: Sassari
country: Italy
facility: Research Site
state: SS
city: Treviso
country: Italy
facility: Research Site
state: TV
city: Varese
country: Italy
facility: Research Site
state: VA
city: Mestre
country: Italy
facility: Research Site
state: VE
city: Verona
country: Italy
facility: Research Site
state: VR
city: Massa Carrara
country: Italy
facility: Research Site
city: Napoli
country: Italy
facility: Research Site
city: Novara
country: Italy
facility: Research Site
city: Roma
country: Italy
facility: Research Site
city: Seongnam
country: Korea, Republic of
facility: Research Site
state: Gyeonggido
city: Daegu
country: Korea, Republic of
facility: Research Site
city: Gwangju
country: Korea, Republic of
facility: Research Site
city: Seoul
country: Korea, Republic of
facility: Research Site
city: Suwon
country: Korea, Republic of
facility: Research Site
city: Wonju
country: Korea, Republic of
facility: Research Site
city: Kuching
country: Malaysia
facility: Research Site
state: Sarawak
city: Kuala Lumpur
country: Malaysia
facility: Research Site
state: Wilayah Persekutuan
city: Penang
country: Malaysia
facility: Research Site
city: Mexico
country: Mexico
facility: Research Site
state: Distrito Federal
city: Guadalajara
country: Mexico
facility: Research Site
state: Jalisco
city: Zapopan
country: Mexico
facility: Research Site
state: Jalisco
city: Monterrey
country: Mexico
facility: Research Site
state: Nuevo Leon
city: Durango
country: Mexico
facility: Research Site
city: Puebla
country: Mexico
facility: Research Site
city: Alkmaar
country: Netherlands
facility: Research Site
city: Almelo
country: Netherlands
facility: Research Site
city: Amersfoort
country: Netherlands
facility: Research Site
city: Amsterdam
country: Netherlands
facility: Research Site
city: Apeldoorn
country: Netherlands
facility: Research Site
city: Arnhem
country: Netherlands
facility: Research Site
city: Assen
country: Netherlands
facility: Research Site
city: Blaricum
country: Netherlands
facility: Research Site
city: Breda
country: Netherlands
facility: Research Site
city: Capelle Aan Den Ijssel
country: Netherlands
facility: Research Site
city: Delft
country: Netherlands
facility: Research Site
city: Den Haag
country: Netherlands
facility: Research Site
city: Deventer
country: Netherlands
facility: Research Site
city: Dordrecht
country: Netherlands
facility: Research Site
city: Drachten
country: Netherlands
facility: Research Site
city: EDE
country: Netherlands
facility: Research Site
city: Eindhoven
country: Netherlands
facility: Research Site
city: Goes
country: Netherlands
facility: Research Site
city: Gorinchem
country: Netherlands
facility: Research Site
city: Gouda
country: Netherlands
facility: Research Site
city: Haarlem
country: Netherlands
facility: Research Site
city: Hardenberg
country: Netherlands
facility: Research Site
city: Harderwijk
country: Netherlands
facility: Research Site
city: Heerlen
country: Netherlands
facility: Research Site
city: Helmond
country: Netherlands
facility: Research Site
city: Hilversum
country: Netherlands
facility: Research Site
city: Leeuwarden
country: Netherlands
facility: Research Site
city: Maastricht
country: Netherlands
facility: Research Site
city: Nieuwegein
country: Netherlands
facility: Research Site
city: Nijmegen
country: Netherlands
facility: Research Site
city: Rotterdam
country: Netherlands
facility: Research Site
city: Spijkenisse
country: Netherlands
facility: Research Site
city: Tiel
country: Netherlands
facility: Research Site
city: Tilburg
country: Netherlands
facility: Research Site
city: Veldhoven
country: Netherlands
facility: Research Site
city: Vlaardingen
country: Netherlands
facility: Research Site
city: Arendal
country: Norway
facility: Research Site
city: Bergen
country: Norway
facility: Research Site
city: Bodo
country: Norway
facility: Research Site
city: Drammen
country: Norway
facility: Research Site
city: Flekkefjord
country: Norway
facility: Research Site
city: Gjovik
country: Norway
facility: Research Site
city: Hamar
country: Norway
facility: Research Site
city: Kongsberg
country: Norway
facility: Research Site
city: Kristiansand
country: Norway
facility: Research Site
city: Lillehammer
country: Norway
facility: Research Site
city: Nordbyhagen
country: Norway
facility: Research Site
city: Notodden
country: Norway
facility: Research Site
city: Oslo
country: Norway
facility: Research Site
city: RUD
country: Norway
facility: Research Site
city: Tromso
country: Norway
facility: Research Site
city: Tynset
country: Norway
facility: Research Site
city: Cebu
country: Philippines
facility: Research Site
city: Davao City
country: Philippines
facility: Research Site
city: Manila
country: Philippines
facility: Research Site
city: Pasig City
country: Philippines
facility: Research Site
city: Quezon City
country: Philippines
facility: Research Site
city: Bialystok
country: Poland
facility: Research Site
city: Bielsko-biala
country: Poland
facility: Research Site
city: Bydgoszcz
country: Poland
facility: Research Site
city: Bytom
country: Poland
facility: Research Site
city: Czestochowa
country: Poland
facility: Research Site
city: Elblag
country: Poland
facility: Research Site
city: Gda?sk
country: Poland
facility: Research Site
city: Gdynia
country: Poland
facility: Research Site
city: Grodzisk Mazowiecki
country: Poland
facility: Research Site
city: Inowroclaw
country: Poland
facility: Research Site
city: Katowice
country: Poland
facility: Research Site
city: Krakow
country: Poland
facility: Research Site
city: Lodz
country: Poland
facility: Research Site
city: Lublin
country: Poland
facility: Research Site
city: Olawa
country: Poland
facility: Research Site
city: Olsztyn
country: Poland
facility: Research Site
city: Opole
country: Poland
facility: Research Site
city: Ostrowiec Swietokrzyski
country: Poland
facility: Research Site
city: Plock
country: Poland
facility: Research Site
city: Poznan
country: Poland
facility: Research Site
city: Radom
country: Poland
facility: Research Site
city: Szczecin
country: Poland
facility: Research Site
city: Tarnow
country: Poland
facility: Research Site
city: Torun
country: Poland
facility: Research Site
city: Walbrzych
country: Poland
facility: Research Site
city: Warszawa
country: Poland
facility: Research Site
city: Wejherowo
country: Poland
facility: Research Site
city: Wloclawek
country: Poland
facility: Research Site
city: Wroclaw
country: Poland
facility: Research Site
city: Zamosc
country: Poland
facility: Research Site
city: Amadora
country: Portugal
facility: Research Site
city: Aveiro
country: Portugal
facility: Research Site
city: Braga
country: Portugal
facility: Research Site
city: Coimbra
country: Portugal
facility: Research Site
city: Leiria
country: Portugal
facility: Research Site
city: Lisboa
country: Portugal
facility: Research Site
city: Penafiel
country: Portugal
facility: Research Site
city: Santa Maria Da Feira
country: Portugal
facility: Research Site
city: Santarem
country: Portugal
facility: Research Site
city: Setubal
country: Portugal
facility: Research Site
city: Vila Nova de Gaia
country: Portugal
facility: Research Site
city: Vila Real
country: Portugal
facility: Research Site
city: San Juan
country: Puerto Rico
facility: Research Site
city: Pitesti
country: Romania
facility: Research Site
state: Arges
city: Cluj Napoca
country: Romania
facility: Research Site
state: Cluj
city: Braila
country: Romania
facility: Research Site
city: Brasov
country: Romania
facility: Research Site
city: Bucharest
country: Romania
facility: Research Site
city: Buzau
country: Romania
facility: Research Site
city: Craiova
country: Romania
facility: Research Site
city: Iasi
country: Romania
facility: Research Site
city: Suceava
country: Romania
facility: Research Site
city: Khanty-mansiysk
country: Russian Federation
facility: Research Site
state: Khanty-mansiysk Autonomous Dis
city: Barnaul
country: Russian Federation
facility: Research Site
city: Ekaterinburg
country: Russian Federation
facility: Research Site
city: Irkutsk
country: Russian Federation
facility: Research Site
city: Kaliningrad
country: Russian Federation
facility: Research Site
city: Kazan
country: Russian Federation
facility: Research Site
city: Kemerovo
country: Russian Federation
facility: Research Site
city: Krasnodar
country: Russian Federation
facility: Research Site
city: Krasnoyarsk
country: Russian Federation
facility: Research Site
city: Moscow
country: Russian Federation
facility: Research Site
city: Murmansk
country: Russian Federation
facility: Research Site
city: Nizhniy Novgorod
country: Russian Federation
facility: Research Site
city: Novosibirsk
country: Russian Federation
facility: Research Site
city: Rostov-na-donu
country: Russian Federation
facility: Research Site
city: Samara
country: Russian Federation
facility: Research Site
city: St. Petersburg
country: Russian Federation
facility: Research Site
city: Tomsk
country: Russian Federation
facility: Research Site
city: Tyumen
country: Russian Federation
facility: Research Site
city: Vladivostok
country: Russian Federation
facility: Research Site
city: Singapore
country: Singapore
facility: Research Site
city: Bratislava
country: Slovakia
facility: Research Site
city: Kosice
country: Slovakia
facility: Research Site
city: Liptovsky Mikulas
country: Slovakia
facility: Research Site
city: Martin
country: Slovakia
facility: Research Site
city: Nitra
country: Slovakia
facility: Research Site
city: Nove Zamky
country: Slovakia
facility: Research Site
city: Piestany
country: Slovakia
facility: Research Site
city: Ruzomberok
country: Slovakia
facility: Research Site
city: Trnava
country: Slovakia
facility: Research Site
city: Zilina
country: Slovakia
facility: Research Site
city: Somerset West
country: South Africa
facility: Research Site
state: Cape Town
city: Bloemfontein
country: South Africa
facility: Research Site
state: Free State
city: Cape Town
country: South Africa
facility: Research Site
city: Pretoria
country: South Africa
facility: Research Site
city: Malaga
country: Spain
facility: Research Site
state: Andalucia
city: Sevilla
country: Spain
facility: Research Site
state: Andalucia
city: Gijon
country: Spain
facility: Research Site
state: Asturias
city: Barcelona
country: Spain
facility: Research Site
state: Cataluna
city: Lerida
country: Spain
facility: Research Site
state: Cataluna
city: Terrassa
country: Spain
facility: Research Site
state: Cataluna
city: Madrid
country: Spain
facility: Research Site
state: Comunidad de Madrid
city: Valencia
country: Spain
facility: Research Site
state: Comunidad Valenciana
city: Caceres
country: Spain
facility: Research Site
state: Extremadura
city: Vigo(pontevedra)
country: Spain
facility: Research Site
state: Galicia
city: Palma de Mallorca
country: Spain
facility: Research Site
state: Islas Baleares
city: Boras
country: Sweden
facility: Research Site
city: Eksjo
country: Sweden
facility: Research Site
city: Eskilstuna
country: Sweden
facility: Research Site
city: Falun
country: Sweden
facility: Research Site
city: Halmstad
country: Sweden
facility: Research Site
city: Jonkoping
country: Sweden
facility: Research Site
city: Kalmar
country: Sweden
facility: Research Site
city: Karlskrona
country: Sweden
facility: Research Site
city: Lidkoping
country: Sweden
facility: Research Site
city: Linkoping
country: Sweden
facility: Research Site
city: Ljungby
country: Sweden
facility: Research Site
city: Lund
country: Sweden
facility: Research Site
city: Ostersund
country: Sweden
facility: Research Site
city: Skovde
country: Sweden
facility: Research Site
city: Stockholm
country: Sweden
facility: Research Site
city: Sundsvall
country: Sweden
facility: Research Site
city: Uppsala
country: Sweden
facility: Research Site
city: Vasteras
country: Sweden
facility: Research Site
city: Mendrisio
country: Switzerland
facility: Research Site
state: Ticino
city: Bellinzona
country: Switzerland
facility: Research Site
city: Bern
country: Switzerland
facility: Research Site
city: Geneve
country: Switzerland
facility: Research Site
city: Kreuzlingen
country: Switzerland
facility: Research Site
city: Lugano
country: Switzerland
facility: Research Site
city: Niao-song-shiang
country: Taiwan
facility: Research Site
state: Kaohsiung
city: Kweishan Shiang
country: Taiwan
facility: Research Site
state: Taoyuan Hsien
city: Taipei
country: Taiwan
facility: Research Site
city: Bangkok
country: Thailand
facility: Research Site
city: Chiang Mai
country: Thailand
facility: Research Site
city: Khon Kaen
country: Thailand
facility: Research Site
city: Istanbul
country: Turkey
facility: Research Site
state: Kartal
city: Ankara
country: Turkey
facility: Research Site
state: Sihhiye
city: Adana
country: Turkey
facility: Research Site
city: Antalya
country: Turkey
facility: Research Site
city: Mersin
country: Turkey
facility: Research Site
city: Dnepropetrovsk
country: Ukraine
facility: Research Site
city: Donetsk
country: Ukraine
facility: Research Site
city: Kharkov
country: Ukraine
facility: Research Site
city: Kiev
country: Ukraine
facility: Research Site
city: Makiyivka
country: Ukraine
facility: Research Site
city: Airdrie
country: United Kingdom
facility: Research Site
state: Lanarkshire
city: Belfast
country: United Kingdom
facility: Research Site
state: Northern Ireland
city: Basingstoke
country: United Kingdom
facility: Research Site
city: Birmingham
country: United Kingdom
facility: Research Site
city: Blackpool
country: United Kingdom
facility: Research Site
city: Dundee
country: United Kingdom
facility: Research Site
city: Edinburgh
country: United Kingdom
facility: Research Site
city: Glasgow
country: United Kingdom
facility: Research Site
city: Leicester
country: United Kingdom
facility: Research Site
city: London
country: United Kingdom
facility: Research Site
city: Manchester
country: United Kingdom
facility: Research Site
city: Middlesborough
country: United Kingdom
facility: Research Site
city: Poole
country: United Kingdom
facility: Research Site
city: Sheffield
country: United Kingdom
facility: Research Site
city: Swansea
country: United Kingdom
facility: Research Site
Study officials:
affiliation: Duke Clinical Research Institute
name: Robert Harrington, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Uppsala Clinical Research Centre
name: Lars Wallentin, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: AstraZeneca
name: Jonathan C. Fox, MD
role: STUDY_DIRECTOR
References:
citation: Natale P, Palmer SC, Saglimbene VM, Ruospo M, Razavian M, Craig JC, Jardine MJ, Webster AC, Strippoli GF. Antiplatelet agents for chronic kidney disease. Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD008834. doi: 10.1002/14651858.CD008834.pub4.
citation: Samman KN, Mehanna P, Takla E, Grenier JC, Chan MY, Lopes RD, Neely ML, Wang TY, Newby LK, Becker RC, Lordkipanidze M, Ruiz M, Hussin JG, Jolicoeur EM. Differential modulation of polyunsaturated fatty acids in patients with myocardial infarction treated with ticagrelor or clopidogrel. Cell Rep Med. 2021 Jun 4;2(6):100299. doi: 10.1016/j.xcrm.2021.100299. eCollection 2021 Jun 15.
citation: Thi Thu Nguyen T, Van Do D, Mellstrom C, Quang Nguyen T, Manh Pham H, Van Hoang S, Cong Luu T, Le Phuong T. Cost-Effectiveness of Ticagrelor Compared with Clopidogrel in Patients with Acute Coronary Syndrome from Vietnamese Healthcare Payers' Perspective. Adv Ther. 2021 Jul;38(7):4026-4039. doi: 10.1007/s12325-021-01743-5. Epub 2021 Jun 11.
citation: Mahmoodi BK, Eriksson N, Vos GJA, Meijer K, Siegbahn A, James S, Wallentin L, Ten Berg JM. Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis. J Am Heart Assoc. 2021 Jun;10(11):e020025. doi: 10.1161/JAHA.120.020025. Epub 2021 May 17.
citation: Gregersen I, Michelsen AE, Lunde NN, Akerblom A, Lakic TG, Skjelland M, Ryeng Skagen K, Becker RC, Lindback J, Himmelmann A, Solberg R, Johansen HT, James SK, Siegbahn A, Storey RF, Kontny F, Aukrust P, Ueland T, Wallentin L, Halvorsen B. Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial. J Am Heart Assoc. 2020 Sep;9(17):e016360. doi: 10.1161/JAHA.120.016360. Epub 2020 Aug 15.
citation: Sumaya W, Wallentin L, James SK, Siegbahn A, Gabrysch K, Himmelmann A, Ajjan RA, Storey RF. Impaired Fibrinolysis Predicts Adverse Outcome in Acute Coronary Syndrome Patients with Diabetes: A PLATO Sub-Study. Thromb Haemost. 2020 Mar;120(3):412-422. doi: 10.1055/s-0039-1701011. Epub 2020 Jan 23.
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citation: Bellavia A, Wallentin L, Orsini N, James SK, Cannon CP, Himmelmann A, Sundstrom J, Renlund H, Lytsy P. Time-based measures of treatment effect: reassessment of ticagrelor and clopidogrel from the PLATO trial. Open Heart. 2017 Jun 1;4(2):e000557. doi: 10.1136/openhrt-2016-000557. eCollection 2017.
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