louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03160001: Niclosamide With Etanercept in Rheumatoid Arthritis
Official title: Adjuvant Use of Niclosamide With Etanercept in Rheumatoid Arthritis: Experimental and Clinical Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Rheumatoid Arthritis (RA)
Keywords: Niclosamide
Rheumatoid arthritis
diseases activity
Efficacy
Safety
Lead sponsor: University of Baghdad
Sponsor class: OTHER
First posted: 2017-05-19
Enrollment: 110
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 1 patient group and 1 placebo group
Primary purpose: OTHER

Brief summary: Assessment of the adjuvant use Niclosamide With Etanercept in Rheumatoid Arthritis

Detailed description: In this randomized double blind placebo-controlled pilot study (Phase I study) we will assess the efficacy and safety of adjuvant use Niclosamide With Etanercept in Rheumatoid Arthritis.

Eligibility criteria: Inclusion Criteria:

* Patients with RA, as defined by the American College of Rheumatology (ACR) 1987 revised criteria or ACR/EULAR 2010,
* Severly Active RA by calculating either DAS28 or SDAI or CDAI.
* Patient selected are those who started etanercept for less than 3months and still active.

Exclusion Criteria:

* Patients on nonsteroidal anti-inflammatory drugs (NSAID) 2 days before entry into this study. or methotrexate (MTX)..
* Patients with hypersensitivity or severe adverse effects to niclosamide .
* Renal impairment.
* Hepatic impairment.
* Pregnancy or a desire to become pregnant.
* Breast feeding.
* Patients with Juvenile RA \[16 years old or younger\].
* Patients using other conventional disease modifying antirheumatic drugs (DMARDs).
* Patients on steroid.
* Patients with coexistence other connective tissue diseases or hypothyroid disease.
* Patient with mild or inactive RA.

Primary outcomes:
measure: Change in disease activity scale
timeFrame: Day 1
Secondary outcomes:
measure: Change in disease activity score
timeFrame: Day 2
measure: disease activity change scale
timeFrame: Day 3
measure: The Change in disease activity scale
timeFrame: 24 hours to 48 hours day
measure: safety of niclosamide
timeFrame: Day 1
Other outcomes:
Locations:
city: Baghdad
country: Iraq
facility: Baghdad teaching Hospital
Study officials:
affiliation: Baghdad Teaching Hospital
name: Ahmed S Mahmood, MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00985101: Study of Cellular Impairments Involved in Diabetic Complications
Official title: Study of the Significance of Mitochondrial Dysfunction for Development of Diabetic Complications
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Diabetes Mellitus
Lead sponsor: Naestved Hospital
Sponsor class: OTHER
First posted: 2009-09-28
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: outpatient diabetes clinic Naestved Hospital, denmark

Brief summary: The purpose of this study is to examine if an early detectable dysfunction in a cellular component (mitochondria) may predict complications in diabetes mellitus.


Eligibility criteria: Inclusion Criteria:

* Diabetes mellitus

Exclusion Criteria:

* Age below 18 yrs
* Psychiatric disease
* Other metabolic disease

Primary outcomes:
measure: endothelial damage
timeFrame: 3 times pr years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05012501: Analysis of Neutrophil Extracellular Traps in Hypercoagulability and Portal Vein Thrombosis in Liver Cirrhosis Patients
Official title: Analysis of Neutrophil Extracellular Traps in Hypercoagulability and Portal Vein Thrombosis in Liver Cirrhosis Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Neutrophil Extracellular Trap Formation
Portal Vein Thrombosis
Liver Cirrhosis
Keywords: Neutrophil Extracellular Trap Formation
Portal Vein Thrombosis
Hypercoagulability
Lead sponsor: The Affiliated Hospital of Qingdao University
Sponsor class: OTHER
First posted: 2021-08-19
Enrollment: 79
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Seventy-nine patients with benign liver cirrhosis treated at the Affiliated Hospital of Qingdao University (China) from September 2020 to January 2021 were recruited for this study, including 26 patients with portal vein thrombosis and 53 patients without portal vein thrombosis.

Brief summary: The aim of this study was to investigate whether NETs markers can enhance procoagulant activity and predict portal vein thrombosis in patients with live cirrhosis, so as to establish a novel predictor to guide clinical decision-making.So we recruit liver cirrhosis with portal vein thrombosis and without portal vein thrombosis treated at the Affiliated Hospital of Qingdao University and collection of blood samples.

Detailed description: Seventy-nine patients with benign liver cirrhosis treated at the Affiliated Hospital of Qingdao University (China) from September 2020 to January 2021 were recruited for this study, including 26 patients with portal vein thrombosis and 53 patients without portal vein thrombosis. NETs markers (Myeloperoxidase, Neutrophil elastase, Citrate histone H3), tissue factor, endotoxin, factor X, TAT complex, and anti-β2 glycoprotein I were detected in plasma using capture ELISA and specific ELISA kits. T-test was performed to analyze whether there was a statistical difference between the two groups, and regression analysis was performed between NETs markers and tissue factor, endotoxin, factor X, TAT complex, and anti-β2 glycoprotein I to investigate whether there was a correlation. This study without any intervention measures, will not cause harm.

Eligibility criteria: Inclusion Criteria:

（1) Clinical diagnosis of liver cirrhosis (2) Clinical diagnosis of portal vein thrombosis

Exclusion Criteria:

1. primary or secondary liver malignancy
2. hematologic diseases
3. Bud-Chiah syndrome
4. incomplete data

Primary outcomes:
measure: Concentration of NETs markers
timeFrame: 1 year.
Secondary outcomes:
Other outcomes:
Locations:
city: Qingdao
country: China
facility: the Affiliated Hospital of Qingdao University
state: Shandong
Study officials:
References:
Clinical trial NCT05774301: Structured Training on Oncology Nurses' Performance Related Port A Cath Device
Official title: Effect of a Structured Simulation-based Training on Oncology Nurses' Performance Regarding Port A Cath Device.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Port a Cath
Keywords: simulated training, oncology nurses, port a cath device
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2023-03-17
Enrollment: 50
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: pre- and post-test
Primary purpose: SUPPORTIVE_CARE

Brief summary: evaluate the effect of structured simulation-based training on oncology nurses' performance regarding port A cath device.

Detailed description: All oncology nurses who are expected to deal with port a-cath device will be recruited in the study pre test will introduced first, then simulated based training will be placed related to port a-cath device care after that , post test will be done immediately and 3 months later to measure nurses knowledge and practice level

Eligibility criteria: Inclusion Criteria:

* Oncology nurses who are providing direct care for patients with port a-cath device

Exclusion Criteria:

* Participants who will not be able to complete the questionnaire

Primary outcomes:
measure: change in oncology nurses' knowledge and practice regarding port a-cath device care
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Heba Abubakr Salama
Study officials:
affiliation: Mansoura University
name: faculty of Nursing
role: STUDY_CHAIR
References:
Clinical trial NCT00636701: Improving Rehabilitation by Magnetic Brain Stimulation
Official title: Improving Rehabilitation by Magnetic Brain Stimulation: Improving Motor Recovery After Stroke
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Stroke
Keywords: Cerebrovascular Accident
rehabilitation
Lead sponsor: VA Office of Research and Development
Sponsor class: FED
First posted: 2008-03-14
Enrollment: 4
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: We hope to understand the properties of the motor cortex in the brain of people with stroke using non-invasive magnetic stimulation.

Detailed description: This case series assesses the effects of five consecutive days of low-frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) with and without a 6-Hz primer. Although this paper studies able-bodied individuals, similar rTMS protocols are used to facilitate motor recovery in patients with hemiplegia following stroke. However, the cortical mechanisms associated with repeated daily doses of rTMS are not completely understood.

Eligibility criteria: Inclusion Criteria:

* 3-24 months post stroke
* upper limb paresis
* CES-D below 16,

Exclusion Criteria:

* history of seizure
* metal in head
* score of less than 24 on the Folstein Mini-Mental Status Exam
* clinical judgement of excessive frailty or lack of stamina (e.g. cannot attend to instructions, stay awake, engage in functional activities)
* serious uncontrolled medical condition
* excessive pain in any joint of the more affected extremity that could limit ability to cooperate with the intervention as judged by the examining clinician

Primary outcomes:
measure: Percentage BOLD (Blood-oxygen-level Dependent Contrast Imaging) Signal From Baseline at 2 Weeks
timeFrame: Baseline (day 0) and 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Decatur
country: United States
facility: Atlanta VA Medical and Rehab Center, Decatur
state: Georgia
Study officials:
affiliation: Atlanta VA Medical and Rehab Center, Decatur
name: Andrew Butler, PhD MS BA
role: PRINCIPAL_INVESTIGATOR
References:
citation: Glielmi CB, Butler AJ, Niyazov DM, Darling WG, Epstein CM, Alberts JL, Hu XP. Assessing low-frequency repetitive transcranial magnetic stimulation with functional magnetic resonance imaging: a case series. Physiother Res Int. 2014 Jun;19(2):117-25. doi: 10.1002/pri.518. Epub 2011 Jul 18.
Clinical trial NCT03813901: Impact of 'Samalochana' Program on Women Who Have Experienced Intimate Partner Violence (IPV)
Official title: Advaita Vedanta and Counselling for Women Who Have Experienced Intimate Partner Violence: Impact on Women's Health
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Domestic Violence
Intimate Partner Violence
Lead sponsor: NMP Medical Research Institute
Sponsor class: OTHER
Collaborators: name: Warwick Research Services
name: Arsha Vidya Study Centre, Tamilnadu, India
First posted: 2019-01-23
Enrollment: 102
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Violence has immediate effects on women's health, which in some cases, is fatal. Physical, mental and behavioural health consequences can also persist long after the violence has stopped. Violence against women and girls occurs in every country and culture and is rooted in social and cultural attitudes and norms that privilege men over women and boys over girls.

Research consistently finds that the more severe the abuse, the greater its impact on women's physical and mental health. In addition, the negative health consequences can persist long after abuse has stopped.Present work shares the impact of arsha vidya counselling for women who has been victim of violence.


Eligibility criteria: Inclusion Criteria:

* Woman
* Able to attend regular counselling
* Planning to remain in area for next 6 months
* have experience intimate partner violence (physical, emotional, psychological, and/or sexual), including coercive control from a current or former partner in the previous 12 months and no later than 3 years.

Exclusion Criteria:

* Man
* Under 19 years of age
* Cannot attend at regular basis
* Living outside of the selected study sites, or planning to relocate in next 4 months
* Separated more than 3 years ago

Primary outcomes:
measure: Change in Quality of Life
timeFrame: Change from baseline to 12-week
Secondary outcomes:
measure: Change in Anxiety
timeFrame: Change from Baseline to 12-weeks
Other outcomes:
Locations:
city: Jaipur
country: India
facility: Divya
state: Rajasthan
Study officials:
affiliation: Warwick Research Services
name: Neha Sharma, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Arsha Vidya Study Centre, India
name: Buddhatmananda Saraswati
role: STUDY_CHAIR
affiliation: Sarvatra International, South Africa
name: Vandana Mishra
role: STUDY_DIRECTOR
References:
Clinical trial NCT04964401: US-Guided ESPB Versus TPVB on Acute and Chronic Pain After VATS
Official title: The Effect of Ultrasound Guided Erector Spinae Plane Block Versus Thoracic Paravertebral Block on Acute and Chronic Pain After Video-Assisted Thoracic Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postoperative Pain
Video-Assisted Thoracoscopic Surgery
Thoracic Paravertebral Block
Erector Spinae Plane Block
Acute Pain
Chronic Pain
Keywords: Chronic pain
Erector spinae plane block
Thoracic paravertebral block
Acute pain
Lead sponsor: Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Sponsor class: OTHER
First posted: 2021-07-16
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Postoperative acute and chronic pain is frequently observed in patients undergoing video assisted thoracoscopic surgery (VATS). This prolongs the discharge time of patients and increases the frequency of postoperative pulmonary complications. Recently, alternative analgesic methods such as thoracic paravertebral block (TPVB) and erector spinae plane block (ESPB), which are thought to have less side effects than thoracic epidural analgesia, have been used. Among these methods, ultrasound (US) guided TPVB is the most preferred method. In addition, ESPB application is increasing in patients undergoing VATS. In the literature, the number of cases performed with ESPB and randomized controlled prospective studies with ESPB are increasing. In this study, it is planned to compare the effects of US-guided TPVB and ESPB on postoperative acute and chronic pain in patients undergoing VATS.


Eligibility criteria: Inclusion Criteria:

* Age between 18 and 80 years
* American Society of Anesthesiologists physical status I-II-III
* Body mass index between 18-30 kg/m2
* Patients undergoing elective video assiste thoracoscopic surgery

Exclusion Criteria:

* Advanced cancer
* History of chronic analgesic therapy
* History of local anesthetic allergy
* Infection in the intervention area
* Patients with bleeding disorders

Primary outcomes:
measure: Pain scores
timeFrame: 24 hours after surgery
Secondary outcomes:
measure: Chronic pain
timeFrame: First and 3th month
Other outcomes:
Locations:
city: Kecioren
country: Turkey
facility: Ankara Atatürk Chest Disease and Chest Surgery Training and Research Hospital
state: Ankara
Study officials:
affiliation: Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
name: Musa Zengin, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00860301: Acupuncture in Infantile Colic
Official title: Acupuncture in Infantile Colic - a Randomised Controlled Double Blind Clinical Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Infantile Colic
Keywords: infantile colic
Lead sponsor: Lund University
Sponsor class: OTHER
Collaborators: name: Ekhagastiftelsen
name: Magn Bergvalls stiftelse
name: General Maternity Hospital Foundation
First posted: 2009-03-12
Enrollment: 90
Sex: ALL
Minimum age (years): 2
Maximum age (years): 8
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to investigate whether acupuncture influences:

* the rate of infants who still fulfil the colic criterion after three intervention weeks
* the time when the infants are crying, fussing or have intense bouts of colicky symptoms

Detailed description: Infantile colic is a common problem. Both the baby and the parents are suffering and there is a risk that the early relationship is disturbed. There is no known treatment that is both effective and harmless. Acupuncture releases different neurotransmitters and hormones, gives pain reduction and affects digestion. Acupuncture in infantile colic has not been studied in a scientific way even though the method is used in many countries. In this randomised study we will investigate if acupuncture affects symptoms in infantile colic.

Eligibility criteria: Inclusion Criteria:

* 2-8 weeks old otherwise healthy infants who are fussing/crying more than three hours/day, more than three days during one week

Exclusion Criteria:

* infants born before week 36
* infants who dont gain weight properly
* infants taking other medicine than dimethicone or lactobacillus reuteri

Primary outcomes:
measure: If the rate of infants who still fulfil the colic criterion in each of the intervention weeks differ between groups.
timeFrame: First, second and third intervention weeks
Secondary outcomes:
measure: If the time when infants are crying, fussing or have intense bouts of colicky symptoms in each of the intervention weeks differ between groups.
timeFrame: First, second and third intervention weeks
Other outcomes:
Locations:
city: Helsingborg
country: Sweden
facility: Acupuncture Clinic
Study officials:
affiliation: Lund University
name: Inger Hallström, Professor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Landgren K.& Hallström I. Akupunkturbehandling vid spädbarnskolik - föräldrars upplevelser av barnets beteende före och efter behandling. Vård i Norden, vol.1, 26-31, 2005.
citation: Landgren K, Kvorning N, Hallstrom I. Feeding, stooling and sleeping patterns in infants with colic--a randomized controlled trial of minimal acupuncture. BMC Complement Altern Med. 2011 Oct 11;11:93. doi: 10.1186/1472-6882-11-93.
Clinical trial NCT00517101: Presence of IBD Specific Antibodies (ASCA, ALCA, ACCA, AMCA) in the Sera of Patients With Spondyloarthropathy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Psoriatic Arthritis
Ankylosing Spondylitis
Undifferentiated Spondyloarthropathy
Keywords: spondyloarthropathy
inflammatory bowel disease
antibodies
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
First posted: 2007-08-16
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: DEFINED_POPULATION
Time perspective: PROSPECTIVE

Brief summary: A relationship between IBD and spondyloarthropathy is well recognized. ASCA ( anti saccharomyces cerevisiae antibodies)are considered to be a serological marker for Crohn's disease and have been studied in patients with spondyloarthropathy with conflicting results. More recently, new serological markers for IBD have been described. These markers are antibodies to certain defined glycans , and their use may permit an improved diagnosis of IBD.

The aim of our study is to investigate wether these new serological markers are present in the sera of patients with spondyloarthropathy.


Eligibility criteria: Inclusion Criteria:

* diagnosis of psoriatic arthritis, ankylosing spondylitis, or undifferentiated spondyloarthropathy

Exclusion Criteria:

* diagnosed inflammatory bowel disease

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Tel-Aviv Sourasky Medical Center
name: valerie aloush, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04209101: Medical Students and Psychoactive Substances Use
Official title: Medical Students and Psychoactive Substances Use: For Whom to Worry?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Psychoactive Substances Consumption
Keywords: Medical student
Psychoactive substances
Alcohol
Tobacco
At risk consumption
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2019-12-23
Enrollment: 942
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: To be included, students had to be aged 18 or more and to be medical students

Brief summary: Medical students are heavy users of psychoactive substances, and even if levels of use vary depending on the universities, the average levels are higher than most other students.

In France, however, the use of licit or illicit substance has not been precisely described in medical students. The aim of this study was therefore to define the different modes of consumption of medical students.

Methods: This study was a cross-sectional survey in medical students from the University of Montpellier, and the investigators performed a cluster analysis of data. Both medical students and residents were included. Socio-demographic, medico-psychological and addictological data were collected.


Eligibility criteria: Inclusion criteria:

* students had to be aged 18
* to be medical students

Exclusion criteria:

- refusal

Primary outcomes:
measure: Define the different modes of consumption
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
affiliation: University Hospital, Montpellier
name: Hélène Donnadieu-Rigole, MD PhD
role: PRINCIPAL_INVESTIGATOR
References: