louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05556330: Computer Guided Versus Free Hand Horizontal Ridge Augmentation in Anterior Mandible.
Official title: Assessment of Horizontal Ridge Augmentation in Anterior Mandible Using Computer Guided Autogenous Cortical Shell Technique Versus Free Hand Technique: Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Computer Guided Alveolar Bone Augmentaion
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2022-09-27
Enrollment: 24
Sex: ALL
Minimum age (years): 25
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Assessment of horizontal ridge augmentation in anterior mandible using computer guided autogenous cortical shell technique versus free hand technique:

randomized clinical trial

Detailed description: patients with deficient anterior mandible were included in this study where control group patients received free hand harvesting and fixation of cortical shells from the symphysis, while the study group patients received the same protocol using 2 patient specific guides (psg) the first guide used for safe and accurate graft harvesting with the proposed dimensions while the second guide used for shell fixation leaving the desired gap with the recipient site that was filled with a particulate mix of xeno and auto grafts .the first guide was fixed in place allowing for accurate harvesting of the cortical shell of desired dimensions from the symphysis Then; the harvested shell was fixed to the second guide outside the patients mouth using micro screws And this fixation guide was finally secured to its final position using two interlocking wings to lock into the first guide at the surgical site as a verification step for the accuracy of the whole procedure. Finally, the 2 guides were removed after shell fixation to the recipient site in a through and through manner st the proposed planed position.

Eligibility criteria: Inclusion Criteria:

* • Age ranges from 25-55 years. No sex predilection.

  * Patients free from any systemic conditions and bone metabolism diseases that might interfere with the surgical intervention, soft tissue or hard tissue healing.
  * Edentulous anterior mandible with horizontally deficient alveolar ridge that is less than 3mm width.
  * Normal vertical dimension with normal inter-arch space.
  * The minimum number of missing teeth in the anterior mandible alveolar ridge is two adjacent teeth.

Exclusion Criteria:

* • Intra-bony lesions (e.g., cysts) or infections (e.g., abscess) that may retard the osteotomy healing.

  * Previous grafting procedures in the edentulous area.

Primary outcomes:
measure: Alveolar ridge horizontal bone gain
timeFrame: one day
Secondary outcomes:
measure: Alveolar ridge horizontal augmentation accuracy in 3D space
timeFrame: one day
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Faculty of Dentistry Cairo University
Study officials:
References:
Clinical trial NCT03445130: A Study of the Effects of Lavender Aromatherapy on Preoperative Anxiety in Breast Surgery Patients
Official title: A Randomized Prospective Placebo-Controlled Study of the Effects of Lavender Aromatherapy on Preoperative Anxiety in Breast Surgery Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anxiety
Keywords: Preoperative Anxiety
Breast Surgery
Lavender Aromatherapy
Lead sponsor: NYU Langone Health
Sponsor class: OTHER
First posted: 2018-02-26
Enrollment: 200
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to determine the effects of lavender aromatherapy on preoperative anxiety by measuring changes in pulse rate and anxiety core using Spielberger State-Trait Anxiety Index questionnaires and on postoperative pain medicine usage. Study participants will then be randomized into one of four groups; either they will receive 2 drops of lavender (Lavandula Angustifolia) oil (LO) or 2 drops of Michelia Alba Leaf oil (MA) or 2 drops of unscented Almond oil (AO) or two drops water on the inside of an oxygen face mask for 15 minutes. Linalool makes up \~30% of Lavandula Angustifolia oil and is believed to be its most active anti-anxiety component. Before and after treatment, anxiety level will be measured using the Spielberger State-Trait Anxiety Inventory.


Eligibility criteria: Inclusion Criteria:

* Women, older than 18, American Society of Anesthesiologists (ASA) classification I-III, undergoing elective breast surgery on Tisch 10th floor Day Surgery. Cancer patients are included.

Exclusion Criteria:

* History of asthma, bronchitis, COPD, contact dermatitis to cosmetic fragrances, positive patch test, pregnancy, and significant laboratory abnormalities.

Primary outcomes:
measure: Reduction in anxiety as measured by the change in baseline STAI scores
timeFrame: 20 Minutes
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: NYU Langone Health
state: New York
Study officials:
affiliation: New York Langone Medical Center
name: Michael Wajda, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06838130: AI-Enhanced Analysis of Breast Density and Background Parenchymal Enhancement (BPE)
Official title: AI-Enhanced Analysis of Breast Density and Background Parenchymal Enhancement (BPE)
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Breast Parenchimal Enhancement
Artificial Intelligence (AI)
Lead sponsor: Link Campus University
Sponsor class: OTHER
Collaborators: name: University of Campania Luigi Vanvitelli
First posted: 2025-02-20
Enrollment: 213
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women aged 18 years and older who underwent CEM for diagnostic or surveillance purposes.

Patients with recorded BPE levels and BI-RADS breast density classification.

Relational database containing structured data for correlation matrix analysis and AI model training.

Brief summary: This study expands upon previous research investigating the correlation between breast density, Background Parenchymal Enhancement (BPE), and age in contrast-enhanced mammography (CEM). By integrating Artificial Intelligence (AI) methodologies, including Artificial Neural Networks (ANNs) and deep learning models, the study aims to optimize the accuracy of predictions and validate prior findings obtained through multiple linear regression.


Eligibility criteria: Patients who underwent CEM, mammography, and ultrasound between May 2022 and June 2023.

Availability of BPE assessment, BI-RADS density classification, and age data.

Complete dataset available for statistical and AI-based analysis.

Exclusion Criteria:

Patients with prior breast cancer treatment that could alter BPE.

Incomplete imaging or missing classification data.

Contraindications to contrast-enhanced imaging.

Primary outcomes:
measure: Correlation between breast density, BPE, and age using AI-driven analysis.
timeFrame: Data analysis within 12 months of study completion.
Secondary outcomes:
measure: AI-based optimization of breast density and BPE classification
timeFrame: Within 12 months of study completion
measure: Comparative performance of multiple linear regression vs. AI models.
timeFrame: Within 12 months of study completion.
measure: Mean Squared Error (MSE) and explained variance in predictive models
timeFrame: Within 12 months of study completion
Other outcomes:
Locations:
city: Naples
country: Italy
facility: University of Campania Luigi Vanvitelli
Study officials:
References:
Clinical trial NCT01639430: Diagnostic Accuracy of Body Temperature Measurement in Geriatric Patients
Official title: Diagnostic Accuracy of Body Temperature Measurement in Geriatric Patients Presenting to the Emergency Department
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Fever
Infection
Lead sponsor: Klinikum Nürnberg
Sponsor class: OTHER
First posted: 2012-07-12
Enrollment: 427
Sex: ALL
Minimum age (years): 75
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Consecutive patients \>= 75 years presenting to the emergency department of an urban university-affiliated hospital (80.000 attendees per year).

Brief summary: Retrospective analysis of a quality measurement project examining the quality of vital parameter measurement in consecutive patients \>= 75 years presenting to the emergency department.

Primary goal of the study is to evaluate the diagnostic accuracy of body temperature measurement using different methods to diagnose infection in patients \>= 75 years presenting to the emergency department. The secondary goal is to compare the reliability of tympanal and temporal artery thermometry with rectal temperature measurement.


Eligibility criteria: Inclusion Criteria:

* \>= 75 years
* given informed consent

Exclusion Criteria:

* patients who do not speak the German language
* patients with unstable cardiorespiratory status
* presence of contraindications to one of the temperature measurement methods

Primary outcomes:
measure: Diagnostic accuracy of rectal, tympanal and temporal artery thermometry to diagnose infection
timeFrame: June 2012
Secondary outcomes:
Other outcomes:
Locations:
city: Nuremberg
country: Germany
facility: Klinikum Nürnberg, emergency department
state: Bavaria
Study officials:
References:
Clinical trial NCT01427530: Local Field Potentials Recorded From Deep Brain Stimulating (DBS) Electrodes
Official title: Local Field Potentials Recorded From Deep Brain Stimulating Electrodes Implanted for the Treatment of Parkinson's Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Parkinson's Disease
Keywords: brain activity
implanted with DBS electrodes
Lead sponsor: University of Minnesota
Sponsor class: OTHER
First posted: 2011-09-01
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Parkinson's disease patients undergoing DBS implantation.

Brief summary: This study will be recording and evaluating brain activity from Deep Brain Stimulating (DBS) electrodes in patients with Parkinson's disease.


Eligibility criteria: Inclusion Criteria:

* Surgical Candidate for DBS implantation.

Primary outcomes:
measure: recording and evaluating brain activity from Deep Brain Stimulating (DBS) electrodes in patients with Parkinson's disease.
timeFrame: At baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Minneapolis
country: United States
facility: Department of Neurosurgery, University of Minnesota
state: Minnesota
Study officials:
affiliation: University of Minnesota
name: Aviva Abosch, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04910230: Nicotinamide-based Supportive Therapy in Lymphopenia for Patients With COVID-19
Official title: Efficiency and Safety of Nicotinamide-based Supportive Therapy in Lymphopenia for Patients With COVID-19: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Covid19
Lymphopenia
Keywords: nicotinamide
COVID19
lymphopenia
Lead sponsor: Shenyang Northern Hospital
Sponsor class: OTHER
First posted: 2021-06-02
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The mechanism of peripheral blood lymphocyte decline in COVID-19 patients is not yet clear. However, one theory demonstrated that in the whole progression of COVID-19, the extensive activation of poly-ADP-ribose polymerase (PARP) may reduce the cellular NAD+ and dampen the adaptive immune system. So investigators presume that replenishing the NAD+ using nicotinamide as the precursor may improve the lymphocyte counts and boost the adaptive immune system. As a result, the study using nicotinamide as a kind of supportive therapy provide further evidence of their efficiency and safety in treating lymphopenia in patients with COVID-19.


Eligibility criteria: Inclusion Criteria:

* the patients diagnosed as the common or severe cases of COVID-19
* aged 18-85
* the absolute lymphocyte counts below the normal value (\<1.1-3.2×109/L)

Exclusion Criteria:

* the patients who are diagnosed as critically ill cases or participating in other clinical trials
* women who are pregnant or lactating
* ALT/AST \> 5 times upper limit of normal (ULN), neutrophils counts \< 0.5×109/L, platelets counts\< 50×109/L
* patients diagnosed with rheumatoid immune-related diseases
* patients who take long-term oral anti-rejection drugs or immunomodulatory drugs
* hypersensitive reaction to nicotinamide or any auxiliary materials
* patients with active tuberculosis or combined with bacterial and fungal infections
* patients undergoing organ transplant
* patients with mental disorders.

Primary outcomes:
measure: changes in absolute lymphocyte counts
timeFrame: before and 48 hours after intervention
Secondary outcomes:
measure: the death in hospital
timeFrame: before and 48 hours after intervention
measure: the composite endpoint of aggravation
timeFrame: before and 48 hours after intervention
Other outcomes:
Locations:
city: Shenyang
country: China
facility: General Hospital of Northern Theater Command
state: Liaoning
Study officials:
affiliation: Department of Cardiology, General Hospital of Northern Theater Command, Shenyang 110016, China
name: Quan-Yu L Zhang, phD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hu Q, Zhang QY, Peng CF, Ma Z, Han YL. Efficiency of nicotinamide-based supportive therapy in lymphopenia for patients with ordinary or severe COVID-19: A randomized controlled trial. Medicine (Baltimore). 2022 Oct 28;101(43):e31138. doi: 10.1097/MD.0000000000031138.
Clinical trial NCT02071030: The Efficacy of Cone Beam Computed Tomography (CBCT) Compared to Panoramic Radiography Prior to Third Molar Removal
Official title: The Efficacy of Cone Beam Computed Tomography (CBCT) Compared to Panoramic Radiography Prior to Third Molar Removal; a Multicentre Randomised Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Inferior Alveolar Nerve Injury
Keywords: CBCT
Third molar removal
Inferior alveolar nerve injury
Lead sponsor: Radboud University Medical Center
Sponsor class: OTHER
First posted: 2014-02-25
Enrollment: 477
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to evaluate the efficacy and cost-effectiveness of Cone Beam Computed Tomography (CBCT) compared to panoramic radiography prior to removal of third molars in reducing patient's morbidity. Adults having a close relationship between the mandibular canal and one or both lower third molars, as diagnosed from digital panoramic radiographs will be recruited for this randomised controlled trial. In one trial arm, patients will receive the standard digital panoramic radiograph prior to third molar surgery. In the second arm, subjects will undergo an additional Cone Beam Computed Tomography (CBCT) prior to third molar surgery.

All patients require a postoperative visit one week after surgery to assess the outcome.


Eligibility criteria: Inclusion Criteria:

* Adults \>18 year
* mandibular canal is superimposed more than one half by the roots of the third molar as assessed on panoramic radiograph.

Exclusion Criteria:

* pregnancy
* radiological evidence of cyst an tumors
* indication for removal under general anesthesia
* preoperative neurosensory alterations
* existence of an external CBCT

Primary outcomes:
measure: Number of participants with inferior alveolar nerve (IAN) injury
timeFrame: 1 week after surgery
Secondary outcomes:
measure: Change in Oral Health related quality of life score
timeFrame: 1 week after surgery
Other outcomes:
measure: Costs of imaging, treatment and day's of work.
timeFrame: 2 weeks after surgery
Locations:
city: Nijmegen
country: Netherlands
facility: Radboud University Medical Centre. Department of Oral & Maxillofacial Surgery
Study officials:
References:
citation: Ghaeminia H, Gerlach NL, Hoppenreijs TJ, Kicken M, Dings JP, Borstlap WA, de Haan T, Berge SJ, Meijer GJ, Maal TJ. Clinical relevance of cone beam computed tomography in mandibular third molar removal: A multicentre, randomised, controlled trial. J Craniomaxillofac Surg. 2015 Dec;43(10):2158-67. doi: 10.1016/j.jcms.2015.10.009. Epub 2015 Oct 23.
Clinical trial NCT04440930: White Tea for Prevention of Chemotherapy Induced Mucositis
Official title: Can White Tea Prevent Oral Mucositis in Patients Receiving Neoadjuvant or Adjuvant Treatment With Paclitaxel for Breast Cancer? A Randomized Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Oral Mucositis
Keywords: mucositis
mouth
paclitaxel
Lead sponsor: Vejle Hospital
Sponsor class: OTHER
First posted: 2020-06-22
Enrollment: 88
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of this study is to determine the effectiveness of mouthwash with white tea in the prevention of paclitaxel induced oral mucositis in women with breast cancer.

Detailed description: Oral mucositis is a common side effect from paclitaxel treatment. It can be very painful and compromise nutrition and oral hygiene, and it may increase the risk of infection. Although oral mucositis is a common side effect to chemotherapy, no available treatment is yet available that can effectively prevent or treat oral mucositis.

Based on the knowledge that white tea has anti-inflammatory, anti-oxidant and anti-microbial effect, the current study aims to assess the effect of mouth wash with white tea on paclitaxel induced oral mucositis in women with breast cancer.

This study is a phase II randomized controlled trial in which eligible patients will be allocated to a control group (CG) and a study group (SG). The CG will use salt water with soda for mouthwash eight to ten times a day and the SG will use white tea for mouthwash five to six times a day.

Eligibility criteria: Inclusion Criteria:

* Woman with breast cancer
* Planned neoadjuvant or adjuvant paclitaxel treatment
* Age ≥ 18 years
* Understand and speak Danish
* Written and orally informed consent

Exclusion Criteria:

- Palliative treatment with paclitaxel

Primary outcomes:
measure: Incidence of oral mucositis grade 2 or higher as measured by the Revised Oral Assessment Guide.
timeFrame: up to nine weeks
Secondary outcomes:
measure: Frequency of daily mouthwashes
timeFrame: once a week over a period of nine weeks
measure: Frequency of daily tooth brushings
timeFrame: once a week over a period of nine weeks
measure: Pain intensity in the oral cavity as measured on the Numeric Rating Scale (NRS).
timeFrame: Once a week over a period of nine weeks
measure: Date of onset of oral mucositis grade 2 or higher as measured by Revised Oral Assessment Guide.
timeFrame: Once a week until oral mucositis occurs up to nine weeks
Other outcomes:
Locations:
city: Vejle
country: Denmark
facility: Department of Oncology, Vejle Hospital
Study officials:
affiliation: Vejle Hospital
name: Erik H Jakobsen, MD
role: STUDY_CHAIR
References:
Clinical trial NCT01175330: Omega 3 Fatty Acid Efficiency for Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting
Official title: Randomized Trial of Fish Oil Infusion to Prevent Atrial Fibrillation After Cardiac Surgery
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Ischemic Heart Disease
Atrial Fibrillation
Keywords: Omega-3 fatty acid
Ischemic Heart Disease
Atrial Fibrillation
Subcutaneous cardiac monitoring
Lead sponsor: Meshalkin Research Institute of Pathology of Circulation
Sponsor class: NETWORK
First posted: 2010-08-04
Enrollment: 39
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate efficacy of Polyunsaturated Fatty Acid for the prevention of Atrial Fibrillation and anti-inflammatory effects in patients after CABG surgery


Eligibility criteria: Inclusion Criteria:

* Elective CABG surgery.
* Signed, documented informed consent prior to admission to the study.

Exclusion Criteria:

* Unstable angina, requiring intervention or CABG \<24 hrs after screening.
* Decompensated congestive heart failure.
* Chronic, persistent, paroxysmal atrial fibrillation.
* Uncorrected significant valvular heart disease
* Known hypersensitivity to the study drug
* Left ventricular dysfunction (ejection fraction \<35%)
* Use of anti-arrhythmic drugs other than beta blockers
* Non-cardiac illness with a life expectancy of less than 1 year
* Bleeding diathesis or history of coagulopathy
* Significant renal and liver insufficiency
* Significant thyroid, pulmonary disease
* Uncontrolled diabetes mellitus
* Patients on anti-arrhythmic drugs
* Patients with pacemaker
* Patients unable to provide/sign informed consent.
* Patients currently taking marine based omega-three fish oil supplements.
* Disturbances in lipid metabolism, serum triglyceride value \>3 mmol/l

Primary outcomes:
measure: Freedom of Atrial Fibrillation or other atrial arrhythmias
timeFrame: 2 years
Secondary outcomes:
measure: All cause mortality
timeFrame: 3 years
Other outcomes:
Locations:
city: Novosibirsk
country: Russian Federation
facility: State Research Institute of Circulation Patholody
Study officials:
References:
citation: Lomivorotov VV, Efremov SM, Pokushalov EA, Romanov AB, Ponomarev DN, Cherniavsky AM, Shilova AN, Karaskov AM, Lomivorotov VN. Randomized trial of fish oil infusion to prevent atrial fibrillation after cardiac surgery: data from an implantable continuous cardiac monitor. J Cardiothorac Vasc Anesth. 2014 Oct;28(5):1278-84. doi: 10.1053/j.jvca.2014.02.019. Epub 2014 Jul 11.