Clinical trial NCT05767138: STI Knowledge and HPV Vaccine Acceptance in Bamako, Mali in 2012
Official title: Knowledge, Attitudes, Practices and Willingness to Vaccinate in Preparation for the Introduction of HPV Vaccines in Bamako, Mali
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: HPV
HPV-Related Cervical Carcinoma
Keywords: Mali
Bamako
Survey
Lead sponsor: Global Alliance to Immunize Against AIDS Vaccine Foundation
Sponsor class: OTHER
Collaborators: name: Merck Sharp & Dohme LLC
First posted: 2023-03-14
Enrollment: 301
Sex: ALL
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants were recruited between May and June 2011 in Mèkin-Sikoro and Djikoroni, two peri-urban communities of Bamako that have been site for previous population surveys. Adolescents were eligible if aged 12-17 years and living in the household, and if a guardian was available to provide consent. Adults (male and female) were eligible if aged \>18 years and living in the household. A total of 301 participants participated (150 living in households in Djikoroni, 151 living in Me´kin-Sikoro)

Brief summary: Although screening for pre-cancerous cervical lesions and human papilloma virus (HPV) vaccination are accepted and effective means to prevent cervical cancer, women in Mali have limited access to these interventions. In addition, cervical cancer prevention by HPV vaccination has been controversial in some settings. To reduce cervical cancer prevalence and increase HPV vaccine uptake, it is important to understand the level of knowledge about cervical cancer screening and practices related to vaccination in at-risk populations. In this study, the level of knowledge about HPV and cervical cancer and attitudes towards vaccination were assessed among 301 participants (male and female, adults and adolescents) in a house-to-house survey in two urban neighborhoods in Bamako, Mali. The survey was combined with a brief educational session on HPV. Prior to the education session, overall knowledge of HPV infection and cervical cancer was very low: only 8% knew that HPV is a sexually transmitted infection (STI). Less than 20% of women had ever consulted a gynecologist and less than 3% had ever had cervical cancer screening. After hearing a description of HPV vaccine, more than 80% would accept HPV vaccination; fathers and husbands were identified as primary decisions makers and local clinics or the home as preferred sites for vaccination. This study provides information on STI knowledge and vaccine acceptance in Bamako, Mali in 2012, prior to the introduction of HPV vaccination.


Eligibility criteria: Inclusion Criteria:

* 12-17 years of age, with guardian consent
* 18 years or older
* Male or Female
* Living in Mèkin-Sikoro and Djikoroni

Exclusion Criteria:

* 12-17 years of age, without guardian consent
* \<12 years of age
* Living outside Mèkin-Sikoro and Djikoroni

Primary outcomes:
measure: Participants' acceptance of the vaccine
timeFrame: immediately after the intervention
Secondary outcomes:
measure: Knowledge of STIs, HPV, and Cervical Cancer
timeFrame: immediately after the intervention
Other outcomes:
Locations:
Study officials:
affiliation: GAIA Vaccine Foundation
name: Anne De Groot, MD
role: PRINCIPAL_INVESTIGATOR
References: