Clinical trial NCT03843125: A Study of Baricitinib in Participants With Systemic Lupus Erythematosus (SLE)
Official title: A Phase 3, Double-Blind, Multicenter Study to Evaluate the Long-Term Safety and Efficacy of Baricitinib in Patients With Systemic Lupus Erythematosus (SLE)
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Systemic Lupus Erythematosus
Keywords: SLE
Lead sponsor: Eli Lilly and Company
Sponsor class: INDUSTRY
Collaborators: name: Incyte Corporation
First posted: 2019-02-15
Enrollment: 1147
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The reason for this long term study is to see how safe and effective the study drug known as baricitinib is in participants with systemic lupus erythematosus (SLE) who have completed the final treatment visit of study I4V-MC-JAHZ (NCT03616912) or study I4V-MC-JAIA (NCT03616964).


Eligibility criteria: Inclusion Criteria:

* Have completed the final treatment study visit of an originating study, such as study JAHZ (NCT03616912) or Study JAIA (NCT03616964).

Primary outcomes:
measure: Percentage of Participants With Treatment-Emergent Adverse Events (TEAEs)
timeFrame: Week 134
measure: Percentage of Participants With Adverse Events of Special Interest (AESIs)
timeFrame: Week 134
measure: Percentage of Participants With Serious Adverse Events (SAEs)
timeFrame: Week 134
measure: Percentage of Participants With Temporary Investigational Product Interruptions
timeFrame: Week 134
measure: Percentage of Participants With Permanent Investigational Product Discontinuations
timeFrame: Week 134
Secondary outcomes:
measure: Percentage of Participants Achieving a Systemic Lupus Erythematosus Responder Index 4 (SRI-4) Response
timeFrame: Week 134
measure: Percentage of Participants Achieving a Lupus Low Disease Activity State (LLDAS)
timeFrame: Week 48
measure: Change From Baseline in Prednisone Dose
timeFrame: Baseline through Week 48
measure: Annualized Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA)-Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) Flare Index Flare Rate
timeFrame: Baseline through Week 48
measure: Percentage of Participants With Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) Total Activity Score ≥10 at Baseline With ≥50% Reduction in CLASI Total Activity Score
timeFrame: Week 48
measure: Change From Baseline in Tender Joint Count
timeFrame: Baseline through Week 48
measure: Change From Baseline in Swollen Joint Count
timeFrame: Baseline trough Week 48
measure: Change From Baseline in Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index Total Score
timeFrame: Baseline through Week 48
measure: Change From Baseline in Worst Pain Numeric Rating Scale (NRS)
timeFrame: Baseline through Week 48
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Achieve Clinical Research, LLC
state: Alabama
city: Phoenix
country: United States
facility: Arizona Arthritis & Rheumatology Research
state: Arizona
city: Tucson
country: United States
facility: Arizona Arthritis & Rheumatology Associates, P. C.
state: Arizona
city: Beverly Hills
country: United States
facility: Wallace Rheumatic Studies Center
state: California
city: Covina
country: United States
facility: Medvin Clinical Research - Weidmann
state: California
city: Fullerton
country: United States
facility: Providence Medical Foundation
state: California
city: Hemet
country: United States
facility: MD Medical Corporation
state: California
city: Poway
country: United States
facility: ACRC Studies
state: California
city: Upland
country: United States
facility: Inland Rheumatology & Osteoporosis Medical Group
state: California
city: Whittier
country: United States
facility: Medvin Clinical Research - Weidmann
state: California
city: Denver
country: United States
facility: Denver Arthritis Clinic - Lowry
state: Colorado
city: Bridgeport
country: United States
facility: New England Research Associates
state: Connecticut
city: Aventura
country: United States
facility: Arthritis and Rheumatic Disease
state: Florida
city: Clearwater
country: United States
facility: Clinical Research of West Florida, Inc. (Clearwater)
state: Florida
city: Miami Lakes
country: United States
facility: Lakes Research, LLC
state: Florida
city: Ormond Beach
country: United States
facility: Millennium Research
state: Florida
city: Plantation
country: United States
facility: Integral Rheumatology & Immunology Specialists
state: Florida
city: Plantation
country: United States
facility: IRIS Research and Development, LLC
state: Florida
city: Tampa
country: United States
facility: ForCare Clinical Research
state: Florida
city: Tampa
country: United States
facility: Tampa Medical Group, P.A.
state: Florida
city: Atlanta
country: United States
facility: Piedmont Healthcare
state: Georgia
city: Atlanta
country: United States
facility: Emory University
state: Georgia
city: Lawrenceville
country: United States
facility: North Georgia Rheumatology, PC
state: Georgia
city: Lexington
country: United States
facility: Arthritis Center of Lexington
state: Kentucky
city: Baltimore
country: United States
facility: Johns Hopkins Asthma and Allergy Center
state: Maryland
city: Detroit
country: United States
facility: Henry Ford Health System
state: Michigan
city: Lansing
country: United States
facility: Advanced Rheumatology, PC
state: Michigan
city: Saint Clair Shores
country: United States
facility: Clinical Research Institute of Michigan, LLC
state: Michigan
city: Kalispell
country: United States
facility: Glacir View Research Institute
state: Montana
city: Reno
country: United States
facility: Allied Clinical Research
state: Nevada
city: Las Cruces
country: United States
facility: Arthritis and Osteoporosis Associates of New Mexico
state: New Mexico
city: Canton
country: United States
facility: St. Lawrence Health System
state: New York
city: Manhasset
country: United States
facility: The Feinstein Institute for Medical Research
state: New York
city: New York
country: United States
facility: Columbia University Medical Center
state: New York
city: New York
country: United States
facility: NYU Langone
state: New York
city: Syracuse
country: United States
facility: SUNY Upstate Medical University
state: New York
city: Charlotte
country: United States
facility: Joint and Muscle Medical Care
state: North Carolina
city: Charlotte
country: United States
facility: Box Arthritis & Rheumatology of the Carolinas, PLLC
state: North Carolina
city: Greensboro
country: United States
facility: Medication Management
state: North Carolina
city: Cincinnati
country: United States
facility: Cincinnati Rheumatic Disease Study Group
state: Ohio
city: Middleburg Heights
country: United States
facility: Paramount Medical Research
state: Ohio
city: Oklahoma City
country: United States
facility: Arthritis & Rheumatology Center of Oklahoma PLLC
state: Oklahoma
city: Oklahoma City
country: United States
facility: Oklahoma Medical Research Foundation
state: Oklahoma
city: Bethlehem
country: United States
facility: East Penn Rheumatology Associates
state: Pennsylvania
city: Wyomissing
country: United States
facility: Clinical Research Center of Reading,LLC
state: Pennsylvania
city: Summerville
country: United States
facility: Articularis Healthcare d/b/a/ Low Country Rheumatology, PA
state: South Carolina
city: Crossville
country: United States
facility: Eagle Medical
state: Tennessee
city: Jackson
country: United States
facility: West Tennessee Research Institute
state: Tennessee
city: Amarillo
country: United States
facility: Amarillo Center for Clinical Research
state: Texas
city: Baytown
country: United States
facility: Accurate Clinical Management
state: Texas
city: Colleyville
country: United States
facility: Dr. Dhiman Basu Private Practice
state: Texas
city: Dallas
country: United States
facility: Metroplex Clinical Research Center
state: Texas
city: Fort Worth
country: United States
facility: Precision Comprehensive Clinical Research Solutions
state: Texas
city: Houston
country: United States
facility: Rheumatology Center Of Houston
state: Texas
city: Houston
country: United States
facility: Accurate Clinical Research
state: Texas
city: Mesquite
country: United States
facility: Southwest Rheumatology, P.A.
state: Texas
city: San Antonio
country: United States
facility: Accurate Clinical Research, Inc.
state: Texas
city: The Woodlands
country: United States
facility: Advanced Rheumatology of Houston
state: Texas
city: Arlington
country: United States
facility: Arthritis Clinic of Northern VA, P.C.
state: Virginia
city: Danville
country: United States
facility: Spectrum Medical Inc.
state: Virginia
city: Glendale
country: United States
facility: Rheumatic Disease Center
state: Wisconsin
city: Ciudad Autónoma de Buenos Aire
country: Argentina
facility: Aprillus Asistencia e Investigacion de Arcis Salud SRL
state: Buenos Aires
city: Ciudad de Buenos Aires
country: Argentina
facility: DOM Centro de Reumatologia
state: Buenos Aires
city: La Plata
country: Argentina
facility: Framingham Centro Medico
state: Buenos Aires
city: Quilmes
country: Argentina
facility: CER Instituto Medico
state: Buenos Aires
city: Quilmes
country: Argentina
facility: Instituto de Investigaciones Clinicas Quilmes
state: Buenos Aires
city: Caba
country: Argentina
facility: Clinica Adventista Belgrano
state: Ciudad Autónoma De Buenos Aire
city: Rosario
country: Argentina
facility: Sanatorio Británico
state: Santa Fe
city: Buenos Aires
country: Argentina
facility: Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno" (CEMIC)
city: Mendoza
country: Argentina
facility: IR Medical Center S.A. Instituto de Reumatologia
city: Tucumán
country: Argentina
facility: Centro de Investigaciones Médicas Tucuman
city: Botany
country: Australia
facility: Optimus Clinical Research
state: New South Wales
city: Maroochydore
country: Australia
facility: The Rheumatology Research Unit Sunshine Coast
state: Queensland
city: Camberwell
country: Australia
facility: Emeritus Research
state: Victoria
city: Fitzroy
country: Australia
facility: St. Vincent's Hospital
state: Victoria
city: Linz
country: Austria
facility: A O Krankenhaus der Elisabethinen
state: Oberösterreich
city: Graz
country: Austria
facility: Medizinische Universität Graz
city: Leuven
country: Belgium
facility: UZ Leuven
state: Vlaams Brabant
city: Brussels
country: Belgium
facility: Cliniques Universitaires Saint-Luc
city: Salvador
country: Brazil
facility: SER - Serviços Especializados em Reumatologia da Bahia S/S - ME
state: Bahia
city: Belo Horizonte
country: Brazil
facility: Santa Casa de Misericordia de Belo Horizonte
state: MG
city: Curitiba
country: Brazil
facility: Centro de Estudos em Terapias Inovadoras-CETI
state: Paraná
city: Curitiba
country: Brazil
facility: EDUMED - Educação em Saúde Ltda.
state: Paraná
city: Porto Alegre
country: Brazil
facility: LMK Serviços Médicos S/S
state: Rio Grande Do Sul
city: Campinas
country: Brazil
facility: Hospital de Clinicas UNICAMP
state: SP
city: Cuiaba
country: Brazil
facility: Oncovida- Centro de Onco-Hematologia de Mato Grosso
city: Valdivia
country: Chile
facility: Clinical Research Chile SpA
state: Los Ríos
city: Providencia
country: Chile
facility: Enroll SpA
state: Región Metropolitana De Santia
city: Osorno
country: Chile
facility: Clinica Alemana de Osorno
city: Santiago
country: Chile
facility: Sociedad Medica Del Aparato Locomotor SA
city: Santiago
country: Chile
facility: Prosalud y cia. Ltda.
city: Vina del Mar
country: Chile
facility: CINVEC- Estudos Clínicos Quinta Región Limitada
city: Guangzhou
country: China
facility: First affiliated Hospital of Sun Yat-Sen University
state: Guangdong
city: Harbin
country: China
facility: First Affiliated Hospital of the Harbin Medical University
state: Heilongjiang
city: Wuhan
country: China
facility: Wuhan Union Hospital
state: Hubei
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
state: Jiangsu
city: Pingxiang
country: China
facility: Pingxiang People's Hospital
state: Jiangxi
city: Changchun
country: China
facility: China-Japan Union Hospital, CJUH.
state: Jilin
city: Shanghai
country: China
facility: Zhongshan Hospital, Fudan University
state: Shanghai
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital
state: Tianjin
city: Urumqi
country: China
facility: People's Hospital of Xinjiang Uygur Autonomous Region
state: Xinjiang
city: Hangzhou
country: China
facility: The Second Affiliated Hospital of Zhejiang University School of Medicine
state: Zhejiang
city: Ningbo
country: China
facility: Ningbo First Hospital
state: Zhejiang
city: Beijing
country: China
facility: Peking University First Hospital
city: Beijing
country: China
facility: Beijing Peking Union Medical College Hospital
city: Shanghai
country: China
facility: Shanghai Huashan Hospital Affil to Fu Dan University
city: Shenyang
country: China
facility: China Medical University (CMU) - First Affiliated Hospital
city: Suzhou Shi
country: China
facility: The First Affliated Hospital of Suzhou University
city: Zhengzhou
country: China
facility: The First Affiliated Hospital of Zhengzhou Universtiy
city: Medellin
country: Colombia
facility: HPTU-El Hospital con alma Pablo Tobon Uribe
state: Antioquia
city: Barranquilla
country: Colombia
facility: Clinica de la Costa
state: Atlantico
city: Barranquilla
country: Colombia
facility: Circaribe SAS
state: Atlántico
city: Bogota
country: Colombia
facility: Idearg S.A.S.
state: Cundinamarca
city: Bucaramanga
country: Colombia
facility: Servimed S.A.S.
state: Santander
city: Cali
country: Colombia
facility: Centro de Medicina Interna
state: Valle Del Cauca
city: Chia
country: Colombia
facility: Preventive Care Ltdac
city: Rijeka
country: Croatia
facility: Klinicki Bolnicki Centar Rijeka
city: Split
country: Croatia
facility: University Hospital Split
city: Praha 2
country: Czechia
facility: Revmatologicky ustav
state: Praha, Hlavní Mešto
city: Brno
country: Czechia
facility: Revmatologie.s.r.o.
city: Olomouc
country: Czechia
facility: Fakultni nemocnice Olomouc
city: Pardubice
country: Czechia
facility: ARTHROHELP s.r.o.
city: Praha 2
country: Czechia
facility: VFN a 1 LF University Karlovy
city: Brest Cedex
country: France
facility: CHRU Brest - Hopital Cavale Blanche
state: Finistère
city: Bordeaux
country: France
facility: Centre hospitalier universitaire Pellegrin
city: Lille Cedex
country: France
facility: CHRU Lille - Hopital Claude Huriez
city: Marseille
country: France
facility: Hopital Européen
city: Strasbourg
country: France
facility: Hôpital de HautePierre
city: Freiburg
country: Germany
facility: Universitätsklinikum Freiburg
state: Baden-Württemberg
city: Tübingen
country: Germany
facility: Universitätsklinikum Tübingen
state: Baden-Württemberg
city: München
country: Germany
facility: Klinikum der Universität München Großhadern
state: Bayern
city: Würzburg
country: Germany
facility: Universitätsklinikum Würzburg A. ö. R.
state: Bayern
city: Mainz
country: Germany
facility: Universitätsmedizin Johannes Gutenberg Universität Mainz
state: Rheinland-Pfalz
city: Dresden
country: Germany
facility: Universitätsklinikum Carl Gustav Carus
state: Sachsen
city: Leipzig
country: Germany
facility: Universitatsklinikum Leipzig
state: Sachsen
city: Berlin
country: Germany
facility: Charité Campus Virchow-Klinikum
city: Berlin
country: Germany
facility: Immanuel Krankenhaus Rheuma Klinik Berlin Buch
city: Berlin
country: Germany
facility: Schlosspark Klinik
city: Köln
country: Germany
facility: Universitaetsklinikum Koeln
city: Athens
country: Greece
facility: Gen Hospital of Athens G Gennimatas
state: Attiki
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion
state: Irakleío
city: Larissa
country: Greece
facility: Regional General University Hospital of Larissa
city: Thessaloniki
country: Greece
facility: Kianous Stavros
city: Thessaloniki
country: Greece
facility: Gen. Hosp. of Thessaloniki "Hippokration"
city: Gyula
country: Hungary
facility: Békés Megyei Központi Kórház Pándy Kálmán Tagkórház
state: Békés
city: Veszprem
country: Hungary
facility: Vital Medical Center
state: Veszprém City
city: Budapest
country: Hungary
facility: Budai Irgalmasrendi Korhaz
city: Budapest
country: Hungary
facility: Qualiclinic
city: Budapest
country: Hungary
facility: Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Orvos-es Egészsegtudomanyi Centrum
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Kozpont
city: Pecs
country: Hungary
facility: Pecsi Tudomanyegyetem Klinikai Kozpont
city: Szeged
country: Hungary
facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont I. Belgyogyaszati Klinika
city: Székesfehérvár
country: Hungary
facility: Vita Verum Egeszsegugyi Szolgaltato Bt
city: Ahmedabad
country: India
facility: Panchshil hospital
state: Gujarat
city: Ahmedabad
country: India
facility: CIMS Hospital Private Limited
state: Gujarat
city: Rajkot
country: India
facility: Shree Giriraj Hospital
state: Gujarat
city: Surat
country: India
facility: Nirmal Hospital Private Limited
state: Gujarat
city: Vadodara
country: India
facility: Sterling Hospital
state: Gujarat
city: Bangalore
country: India
facility: ChanRe Rheumatology And Immunology Center And Research
state: Karnataka
city: Bangalore
country: India
facility: St. John Medical College & Hospital
state: Karnataka
city: Hubli
country: India
facility: Sushruta Multispecialty Hospital & Research Center Pvt Ltd
state: Karnataka
city: Madhav Nagar, Manipal
country: India
facility: Kasturba Medical College Hospital, Mangalore
state: Karnataka
city: Nagpur
country: India
facility: Jasleen Hospital
state: Maharashtra
city: Nashik
country: India
facility: Synexus Affiliate - Sujata Birla Hospital & Medical Research Center
state: Maharashtra
city: Jaipur
country: India
facility: Fortis Escorts Hospital
state: Rajasthan
city: Secunderabad
country: India
facility: Krishna Institute of Medical Science
state: Telengana
city: Kfar Saba
country: Israel
facility: Meir Medical Center
city: Ramat Gan
country: Israel
facility: Sheba Medical Center
city: Haifa
country: Israel
facility: Carmel Hospital
state: Ḥeifā
city: Milano
country: Italy
facility: Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico
city: Pisa
country: Italy
facility: Azienda Ospedaliera Universitaria Pisana
city: Roma
country: Italy
facility: Azienda Policlinico Umberto I
city: Udine
country: Italy
facility: Azienda Ospedaliera Santa Maria Della Misericordia
city: Kitakyushu
country: Japan
facility: University of Occupational and Enviromental Health
state: Fukuoka
city: Asahikawa
country: Japan
facility: National Hospital Organization Asahikawa Medical Center
state: Hokkaido
city: Sapporo
country: Japan
facility: Hokkaido University Hospital
state: Hokkaido
city: Himeji
country: Japan
facility: Jp Red Cross Society Himeji Hp
state: Hyogo
city: Kobe
country: Japan
facility: Kobe University Hospital
state: Hyogo
city: Kita-gun
country: Japan
facility: Kagawa University Hospital
state: Kagawa
city: Sendai-shi
country: Japan
facility: Tohoku University Hospital
state: Miyagi
city: Tomigusuku
country: Japan
facility: Tomishiro Central Hospital
state: Okinawa
city: Hamamatsu
country: Japan
facility: Seirei Hamamatsu General Hospital
state: Shizuoka
city: Bunkyo-ku
country: Japan
facility: Juntendo University Hospital
state: Tokyo
city: Bunkyo-Ku
country: Japan
facility: Nippon Medical School Hospital
state: Tokyo
city: Shinagawa
country: Japan
facility: Showa University Hospital
state: Tokyo
city: Fukuoka
country: Japan
facility: National Hospital Organization Kyushu Medical Center
city: Fukuoka
country: Japan
facility: Hamanomachi Hospital
city: Hiroshima
country: Japan
facility: Hiroshima University Hospital
city: Tokyo
country: Japan
facility: St. Luke's International Hospital
city: Tokyo
country: Japan
facility: Keio university hospital
city: Seongnam-si
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyeonggi-do
city: Daegu
country: Korea, Republic of
facility: Kyung Pook National University Hospital
state: Korea
city: Daejeon
country: Korea, Republic of
facility: Chungnam National University Hospital
state: Korea
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Hospital
state: Korea
city: Seoul
country: Korea, Republic of
facility: Hanyang University Medical Center
state: Korea
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
state: Korea
city: Seoul
country: Korea, Republic of
facility: Seoul St. Mary's Hospital
state: Korea
city: Torreon
country: Mexico
facility: Dr. Alberto Esteban Bazzoni Ruiz
state: Coahuila
city: Mexico City
country: Mexico
facility: Clinica para el Diagnostico y Tratamiento de la Enfermedades
state: Distrito Federal
city: Leon
country: Mexico
facility: Morales Vargas Centro de Investigacion, S.C.
state: Guanajuato
city: Guadalajara
country: Mexico
facility: Centro Integral en Reumatologia SA de CV
state: Jalisco
city: Guadalajara
country: Mexico
facility: Clinica de Investigacion en Reumatologia y Obesidad S. C.
state: Jalisco
city: Guadalajara
country: Mexico
facility: Centro de Estudios de Investigacion Metabolicos y Cardiovasculares
state: Jalisco
city: Zapopan
country: Mexico
facility: Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V.
state: Jalisco
city: San Luis Potosi
country: Mexico
facility: Centro de Alta Especialidad Reumatologia Inv del Potosi SC
state: SLP
city: Villahermosa
country: Mexico
facility: Consultorio Jose Luis Garcia Figueroa
state: Tabasco
city: Merida
country: Mexico
facility: Köhler & Milstein Research
state: Yucatan
city: Merida
country: Mexico
facility: Centro Peninsular de Investigacion S.C.P
state: Yucatán
city: Merida
country: Mexico
facility: Cemdeicy S.C.P.
state: Yucatán
city: Ciudad De México
country: Mexico
facility: Centro de Investigación y Tratamiento Reumatológico S.C
city: Mexico City
country: Mexico
facility: Clinosar Mexico S.A. de C.V
city: Mexico City
country: Mexico
facility: Consultorio de Reumatologia
city: Oaxaca
country: Mexico
facility: Oaxaca Site Management Organization
city: Leeuwarden
country: Netherlands
facility: Medische Centrum Leeuwarden
state: Fryslân
city: Amsterdam
country: Netherlands
facility: Vrije Universiteit Medisch Centrum Amsterdam
city: Lipa
country: Philippines
facility: Mary Mediatrix Medical Center
state: Batangas
city: Cebu City
country: Philippines
facility: Cebu Doctors Hospital
state: Cebu
city: Cebu City
country: Philippines
facility: Chong Hua Hospital
state: Cebu
city: Davao
country: Philippines
facility: Southern Philippines Medical Center
state: Davao Del Norte
city: Makati
country: Philippines
facility: Makati Medical Center
state: Luzon
city: Quezon City
country: Philippines
facility: St. Luke's Medical Center
state: Luzon
city: Angeles City
country: Philippines
facility: Angeles University Foundation and Medical Center
state: Pampanga
city: Wroclaw
country: Poland
facility: Niepubliczny Zaklad Opieki Zdrowotnej Biogenes Sp. z o.o.
state: Dolnoslaskie
city: Bydgoszcz
country: Poland
facility: Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy, Klinika Reumatologii i Chorob Tkanki Lacznej
state: Kujawsko-pomorskie
city: Nowa Sol
country: Poland
facility: Twoja Przychodnia Centrum Medyczne Nowa Sol
state: Lubuskie
city: Warszawa
country: Poland
facility: Medycyna Kliniczna
state: Mazowieckie
city: Warszawa
country: Poland
facility: Reumatika - Centrum Reumatologii
state: Mazowieckie
city: Bialystok
country: Poland
facility: Gabinet Internistyczno- Reumatologiczny Piotr Adrian Klimiuk
state: Podlaskie
city: Lublin
country: Poland
facility: Zespol Poradni Specjalistycznych REUMED
state: Polska
city: Elblag
country: Poland
facility: Ambulatorium Barbara Bazela
state: Warminsko-Mazurki
city: Katowice
country: Poland
facility: Centrum Medyczne Pratia Katowice
city: Krakow
country: Poland
facility: MCM Krakow - PRATIA - PPDS
city: Krakow
country: Poland
facility: Centrum Medyczne Plejady
city: Nadarzyn
country: Poland
facility: NZOZ Lecznica MAK-MED s.c.
city: Poznan
country: Poland
facility: Klinika Reumatologii i Rehabilitacji
city: Szczecin
country: Poland
facility: Klinika Reumatologii, Chorob Wewnetrznych i Geriatrii PUM
city: Warszawa
country: Poland
facility: Centrum Medyczne AMED
city: Brasov
country: Romania
facility: C.M.D.T.A. Neomed
state: Brașov
city: Bucureti
country: Romania
facility: Spitalul Euroclinic
state: București
city: Napoca
country: Romania
facility: Napoca Emergency Clinical County Hospital
state: Cluj
city: Craiova
country: Romania
facility: Craiova Emergency Clinical County Hospital
state: Dolj
city: Bucharest
country: Romania
facility: SANA Medical Center
city: Bucuresti
country: Romania
facility: Spitalul Clinic Sf Maria Bucuresti
city: Bucuresti
country: Romania
facility: Spitalul Clinic "Dr. Ioan Cantacuzino"
city: Moscow
country: Russian Federation
facility: Moscow City Clinical Hospital Number 52
state: Moskva
city: St. Petersburg
country: Russian Federation
facility: LLC MK Med
state: Saint Petersburg
city: Chelyabinsk
country: Russian Federation
facility: Chelyabinsk Regional Clinical Hospital
city: Kazan
country: Russian Federation
facility: City Hospital # 7
city: Moscow
country: Russian Federation
facility: V.A. Nasonova Research Institute of Rheumatology
city: Moscow
country: Russian Federation
facility: Russian National Research Medical University n.a. N.I.Pirogov
city: Moscow
country: Russian Federation
facility: City Clinical Hospital 1 named after N.I. Pirogov
city: Novosibirsk
country: Russian Federation
facility: Research Institute of Clinical Immunology
city: Novosibirsk
country: Russian Federation
facility: Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Medical Sciences
city: Omsk
country: Russian Federation
facility: Regional Hospital - Omsk
city: Orenburg
country: Russian Federation
facility: Orenburg State Medical Academy of Roszdrav
city: Rursk
country: Russian Federation
facility: Kursk Regional Clinical Hospital
city: Ryazan
country: Russian Federation
facility: Ryazan State Medical University
city: Saint Petersburg
country: Russian Federation
facility: Russian Medical Military Academy n.a. S.M. Kirov
city: Smolensk
country: Russian Federation
facility: Departmental Hospital at Smolensk Station "rzhd" JSC
city: Ufa
country: Russian Federation
facility: Kuvatov Republican Clinical Hospital
city: Zonova
country: Russian Federation
facility: LLC Medical Center Zdorovaya Semiya
city: Belgrade
country: Serbia
facility: Institute of Rheumatology
city: Belgrade
country: Serbia
facility: Military Medical Academy
city: Belgrade
country: Serbia
facility: University Clinical Center of Serbia
city: Niska Banja
country: Serbia
facility: Institute for Treatment and Rehabilitation Niska Banja
city: Novi Sad
country: Serbia
facility: Clinical Center of Vojvodina
city: Umhlanga
country: South Africa
facility: Suite 509 Umhlanga Netcare Medical Centre
state: Durban
city: Johannesburg
country: South Africa
facility: WITS Clinical Research
state: Gauteng
city: Pretoria
country: South Africa
facility: Jakaranda Hospital
state: Gauteng
city: Cape Town
country: South Africa
facility: Vincent Pallotti Hospital
state: Western Cape
city: Cape Town
country: South Africa
facility: Panorama Medical Centre
state: Western Cape
city: Stellenbosch
country: South Africa
facility: Winelands Medical Research Centre
state: Western Cape
city: Pretoria
country: South Africa
facility: University Of Pretoria
city: La Vila Joiosa
country: Spain
facility: Hospital Marina Baixa
state: Alicante
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d'Hebron
state: Barcelona [Barcelona]
city: Sabadell
country: Spain
facility: Corporacion Sanitaria Parc Tauli
state: Barcelona
city: Fuenlabrada
country: Spain
facility: Hospital De Fuenlabrada
state: Madrid
city: Vigo
country: Spain
facility: Hospital do Meixoeiro
state: Pontevedra
city: Barcelona
country: Spain
facility: Corporació Sanitària Clínic
city: Sevilla
country: Spain
facility: Hospital Quiron Infanta Luisa
city: st.Gallen
country: Switzerland
facility: Cantonal Hospital St.Gallen
state: Sankt Gallen
city: Dalin Township
country: Taiwan
facility: Hualien Tzu-Chi Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Veterans General Hospital
city: Kaohsiung
country: Taiwan
facility: Chang Gung Memorial Hospital - Kaohsiung Branch
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Tainan City
country: Taiwan
facility: Chi-Mei Medical Center
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipei Medical University Hospital
city: Taoyuan City
country: Taiwan
facility: Chang Gung Memorial Hospital - Linkou
city: Maidstone
country: United Kingdom
facility: Maidstone Hospital
state: Kent
city: Leytonstone
country: United Kingdom
facility: Whipps Cross University Hospital
state: London
city: Tooting
country: United Kingdom
facility: St George's Hospital
state: London
city: London
country: United Kingdom
facility: Guys/St. Thomas Hospital
state: Surrey
city: Doncaster
country: United Kingdom
facility: Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust
city: Leeds
country: United Kingdom
facility: Leeds Teaching Hospital
Study officials:
affiliation: Eli Lilly and Company
name: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
role: STUDY_DIRECTOR
References: