Clinical trial NCT04967404: The Effect of Phosphatidylserine on Time Trial Performance in Trained Male Cyclists
Official title: The Effect of Phosphatidylserine on Time Trial Performance in Trained Male Cyclists
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: The Focus of the Study is to Investigate the Effects of Phosphatidylserine Supplementation on Exercise Physiology and Cycling Time-trial Performance
Lead sponsor: St Mary's University College
Sponsor class: OTHER
First posted: 2021-07-19
Enrollment: 20
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants matched on cycling time-trial performance and then randomly assigned to treatment or placebo groups
Primary purpose: BASIC_SCIENCE

Brief summary: Phosphatidylserine is a phospholipid found in high concentrations in the brain and nervous tissues along with naturally occurring in many foods. It has been extensively studied for its effects on improving cognitive function, learning, memory and alleviating stress. However, more recently it has been proposed that phosphatidylserine could improve exercise capacity. The mechanisms of proposed action are difficult to distinguish because of the limited research and therefore the purpose of this study is to identify the proposed mechanism of action of phosphatidylserine supplementation and to establish whether these mechanisms will have an effect on time trial performance in trained male cyclists.


Eligibility criteria: Inclusion Criteria:

* Cyclists
* Maximum oxygen uptake of at least 55 mL/kg/min

Exclusion Criteria:

Primary outcomes:
measure: 30 minute cycling time-trial power output on an electromagnetically-braked cycle ergometer
timeFrame: From baseline to 11 days post supplementation
Secondary outcomes:
measure: Oxygen consumption at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
timeFrame: From baseline to 11 days post supplementation
measure: Respiratory exchange ratio at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
timeFrame: From baseline to 11 days post supplementation
measure: Breathing frequency at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
timeFrame: From baseline to 11 days post supplementation
measure: Minute ventilation at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
timeFrame: From baseline to 11 days post supplementation
measure: Blood lactate concentration at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
timeFrame: From baseline to 11 days post supplementation
measure: Blood glucose concentration at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
timeFrame: From baseline to 11 days post supplementation
measure: Rating of perceived exertion at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
timeFrame: From baseline to 11 days post supplementation
measure: Heart rate at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
timeFrame: From baseline to 11 days post supplementation
Other outcomes:
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