Clinical trial NCT01840865: Effects of Brain Stimulation During Daytime Nap on Memory Consolidation in Younger, Healthy Subjects
Official title: Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Daytime Slow Wave Sleep in Younger, Healthy Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Subjects
Keywords: young healthy subjects
brain stimulation
tSOS
tDCS
sleep
daytime sleep
nap
memory
memory consolidation
Lead sponsor: Charite University, Berlin, Germany
Sponsor class: OTHER
First posted: 2013-04-26
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The beneficial effect of daytime sleep on memory consolidation has been shown in young, healthy subjects. Especially, periods rich in slow-wave sleep (SWS) have shown a memory enhancing effect on hippocampus-dependent declarative memory. Slow oscillatory activity typically occuring during SWS has been implicated in the consolidation effect. In this study we investigate if the consolidation effect can be amplified by the application of a weak transcranial oscillatory electric current within the frequency range of SWS in humans (0,7-0,8 Hz) during daytime SWS.


Eligibility criteria: Inclusion Criteria:

* healthy Subjects
* unobtrusive, neuropsychological screening
* age: 18-35 years
* right handed

Exclusion Criteria:

* untreated severe internal or psychiatric diseases
* epilepsy
* other severe neurological diseases eg., previous major stroke, brain tumour
* contraindications to MRI

Primary outcomes:
measure: Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS
timeFrame: 4 weeks
Secondary outcomes:
measure: Amount of Slow wave Sleep
timeFrame: 4 weeks
measure: 2. sleep spindles
timeFrame: 4 weeks
measure: 3. EEG-correlates
timeFrame: 4 weeks
measure: 4. further memory systems
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Berlin
country: Germany
facility: Charite CCM Neurologie Berlin
Study officials:
affiliation: Charite Universitätsmedizin Berlin - Neurologie
name: Agnes Flöel, Professor
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Diekelmann S, Born J. The memory function of sleep. Nat Rev Neurosci. 2010 Feb;11(2):114-26. doi: 10.1038/nrn2762. Epub 2010 Jan 4.
citation: Mednick SC, Cai DJ, Kanady J, Drummond SP. Comparing the benefits of caffeine, naps and placebo on verbal, motor and perceptual memory. Behav Brain Res. 2008 Nov 3;193(1):79-86. doi: 10.1016/j.bbr.2008.04.028. Epub 2008 May 8.
citation: Mander BA, Santhanam S, Saletin JM, Walker MP. Wake deterioration and sleep restoration of human learning. Curr Biol. 2011 Mar 8;21(5):R183-4. doi: 10.1016/j.cub.2011.01.019. No abstract available.
citation: Mednick S, Nakayama K, Stickgold R. Sleep-dependent learning: a nap is as good as a night. Nat Neurosci. 2003 Jul;6(7):697-8. doi: 10.1038/nn1078.
citation: Ladenbauer J, Ladenbauer J, Kulzow N, Floel A. Memory-relevant nap sleep physiology in healthy and pathological aging. Sleep. 2021 Jul 9;44(7):zsab002. doi: 10.1093/sleep/zsab002.