Clinical trial NCT05100862: A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
Official title: A Phase 3 Randomized, Open-Label Multicenter Study of Zanubrutinib (BGB-3111) Plus Anti-CD20 Antibodies Versus Lenalidomide Plus Rituximab in Patients With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Relapsed/Refractory Follicular Lymphoma
Marginal Zone Lymphoma
Keywords: Zanubrutinib
BGB-3111
Rituximab
Lenalidomide
Obinutuzumab
Lead sponsor: BeiGene
Sponsor class: INDUSTRY
First posted: 2021-10-29
Enrollment: 780
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to compare the efficacy of zanubrutinib plus obinutuzumab versus lenalidomide plus rituximab (R\^2) in participants with relapsed/refractory (R/R) follicular lymphoma (FL), as measured by progression-free survival as determined by an independent review committee in accordance with the 2014 modification of the International Working Group on non-Hodgkin lymphoma (NHL) Criteria based on n positron emission tomography and computed tomography (PET/CT), and to compare the efficacy of zanubrutinib plus rituximab versus R\^2 in participants with R/R marginal zone lymphoma (MZL), as measured by progression free survival (PFS) assessed by IRC in accordance with CT-based Lugano 2014 Criteria.


Eligibility criteria: Key Inclusion Criteria:

* Histologically confirmed grade 1-3a FL or MZL
* Previously treated with ≥ 1 line of systemic therapy including anti-CD20 agent. Must have a documented failure to achieve at least partial response during the most recent systemic therapy or documented progressive disease after the most recent systemic therapy
* Need for systemic therapy for FL or MZL
* Measurable disease by computed tomography or magnetic resonance imaging
* Adequate bone marrow, liver and renal function

Key Exclusion Criteria:

* Transformation to aggressive lymphoma
* Requiring ongoing need for corticosteroid treatment
* Clinically significant cardiovascular disease
* Prior malignancy within the past 2 years
* Active fungal, bacterial, and/or viral infection that requires systemic therapy
* Prior treatment with lenalidomide or drug from same class, if without response (partial or complete) or short remission duration (\< 24 months)

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Primary outcomes:
measure: Progression-free Survival As Determined By A Blinded Independent Review Committee (BIRC)
timeFrame: Approximately 78 months
Secondary outcomes:
measure: Progression-free Survival As Determined By Investigator Assessment
timeFrame: Approximately 87 months
measure: Duration Of Response As Determined By BIRC And By Investigator Assessment
timeFrame: Approximately 87 months
measure: Overall Response Rate As Determined By BIRC And By Investigator Assessment
timeFrame: Approximately 87 months
measure: Complete Response Rate As Determined By BIRC And By Investigator Assessment
timeFrame: Approximately 87 months
measure: Time To Response As Determined By BIRC And By Investigator Assessment
timeFrame: Approximately 87 months
measure: Time to Next Ant-Lymphoma Treatment
timeFrame: Approximately 87 months
measure: Overall Survival
timeFrame: Approximately 87 months
measure: Health-related Quality Of Life (HRQoL) Using EORTC QLQ-C30)
timeFrame: Approximately 87 months
measure: HRQoL Using European Quality of Life 5 Dimension 5 Level Questionnaire [EQ 5D 5L)
timeFrame: Approximately 87 months
measure: HRQoL Using National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy Lymphoma Symptom Index-18 [FLymSI 18)
timeFrame: Approximately 87 months
measure: Number of Participants Experiencing Adverse Events (AEs)
timeFrame: From first dose to 28 days after the last dose of zanubrutinib or lenalidomide, 90 days after the last dose of obinutuzumab or rituximab, or until the date of confirmed disease progression, whichever comes later (Approximately 87 months)
Other outcomes:
Locations:
city: Fresno
country: United States
facility: Ucsf Fresno University of California San Francisco Fresno
state: California
city: Irvine
country: United States
facility: Kaiser Permanente Southern California
state: California
city: Los Alamitos
country: United States
facility: Cancer and Blood Specialty Clinic
state: California
city: Los Angeles
country: United States
facility: Los Angeles Cancer Network
state: California
city: Los Angeles
country: United States
facility: Valkyrie Clinical Trials
state: California
city: Los Angeles
country: United States
facility: UCLA Hematologyoncology
state: California
city: San Diego
country: United States
facility: Scripps Health
state: California
city: San Diego
country: United States
facility: Sharp Healthcare Sharp Memorial Hospital
state: California
city: Jacksonville
country: United States
facility: Baptist Md Anderson Cancer Center
state: Florida
city: Pembroke Pines
country: United States
facility: Memorial Cancer Institute, Memorial Healthcare System
state: Florida
city: Pensacola
country: United States
facility: Ascension Sacred Heart
state: Florida
city: Marietta
country: United States
facility: Northwest Georgia Oncology Centers Marietta
state: Georgia
city: Decatur
country: United States
facility: Cancer Care Specialists of Illinois
state: Illinois
city: Fort Wayne
country: United States
facility: Fort Wayne Medical Oncology and Hematology
state: Indiana
city: Waukee
country: United States
facility: Mission Cancer and Blood
state: Iowa
city: Topeka
country: United States
facility: Cotton Oneil Cancer Center
state: Kansas
city: Wichita
country: United States
facility: Cancer Center of Kansas
state: Kansas
city: Lexington
country: United States
facility: Baptist Health Lexington
state: Kentucky
city: Shreveport
country: United States
facility: Christus Highland Cancer Treatment Center
state: Louisiana
city: Annapolis
country: United States
facility: Luminis Health Anne Arundel Medical Center
state: Maryland
city: Baltimore
country: United States
facility: University of Maryland Greenebaum Comprehensive Cancer Center
state: Maryland
city: Baltimore
country: United States
facility: Ascension St Agnes Hospital
state: Maryland
city: Bethesda
country: United States
facility: American Oncology Partners of Maryland Pa
state: Maryland
city: Detroit
country: United States
facility: Henry Ford Hospital
state: Michigan
city: Grand Rapids
country: United States
facility: Corewell Health the Michigan Cancer Consortium
state: Michigan
city: Grosse Pointe Woods
country: United States
facility: Ascension St John Hospital
state: Michigan
city: Hattiesburg
country: United States
facility: Hattiesburg Hematology and Oncology Clinic
state: Mississippi
city: Columbia
country: United States
facility: University of Missouri Hospital, Ellis Fischel Cancer Center
state: Missouri
city: Springfield
country: United States
facility: Oncology Hematology Associates
state: Missouri
city: Billings
country: United States
facility: St Vincent Frontier Cancer Center
state: Montana
city: Omaha
country: United States
facility: Nebraska Cancer Specialists (Satellite Site)
state: Nebraska
city: Omaha
country: United States
facility: Nebraska Cancer Specialists
state: Nebraska
city: Las Vegas
country: United States
facility: Comprehensive Cancer Centers of Nevada
state: Nevada
city: Bayonne
country: United States
facility: Iyengar Hematology Oncology Medical Center Pa
state: New Jersey
city: Bronx
country: United States
facility: North Shore Hematology Oncology Associates Eccc Bronx
state: New York
city: East Setauket
country: United States
facility: New York Cancer and Blood Specialists
state: New York
city: New Hyde Park
country: United States
facility: North Shore Hematology Oncology Associates New Hyde Park
state: New York
city: New York
country: United States
facility: North Shore Hematology Oncology Associates Dba New York Cancer and Blood Specialists (New York)
state: New York
city: Syracuse
country: United States
facility: Suny Upstate Medical University
state: New York
city: Westbury
country: United States
facility: Clinical Research Alliance, Inc
state: New York
city: Charlotte
country: United States
facility: Levine Cancer Institute Wake Forest
state: North Carolina
city: Cincinnati
country: United States
facility: Oncology Hematology Care Clinical Trials, Llc
state: Ohio
city: Wynnewood
country: United States
facility: Mainline Health Lankenau Institute For Medical Research
state: Pennsylvania
city: York
country: United States
facility: Cancer Care Associates of York
state: Pennsylvania
city: Watertown
country: United States
facility: Prairie Lakes Healthcare System
state: South Dakota
city: Dallas
country: United States
facility: Texas Oncology Baylorcharles A Sammons Cancer Center
state: Texas
city: Houston
country: United States
facility: Harris Health Lyndon B Johnson Hospital
state: Texas
city: Houston
country: United States
facility: Md Anderson Cancer Center
state: Texas
city: Longview
country: United States
facility: Texas Oncology Longview Cancer Center
state: Texas
city: Palestine
country: United States
facility: Texas Oncology Palestine Cancer Center
state: Texas
city: Paris
country: United States
facility: Texas Oncology Paris
state: Texas
city: Tyler
country: United States
facility: Northeast Texas Cancer and Research Institute
state: Texas
city: Puyallup
country: United States
facility: Northwest Medical Specialties
state: Washington
city: Seattle
country: United States
facility: University of Washington
state: Washington
city: Spokane
country: United States
facility: Medical Oncology Associates
state: Washington
city: Caba
country: Argentina
facility: Hospital Aleman
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Hospital Italiano de Buenos Aires
city: Concord
country: Australia
facility: Concord Repatriation General Hospital
state: New South Wales
city: Gosford
country: Australia
facility: Gosford Hospital
state: New South Wales
city: Kogarah
country: Australia
facility: St George Hospital
state: New South Wales
city: Orange
country: Australia
facility: Orange Health Hospital
state: New South Wales
city: Port Macquarie
country: Australia
facility: Port Macquarie Base Hospital
state: New South Wales
city: Westmead
country: Australia
facility: Westmead Hospital
state: New South Wales
city: Birtinya
country: Australia
facility: Sunshine Coast Hospital and Health Service
state: Queensland
city: Douglas
country: Australia
facility: Townsville University Hospital
state: Queensland
city: North Adelaide
country: Australia
facility: Genesiscare North Adelaide
state: South Australia
city: Clayton
country: Australia
facility: Monash Health
state: Victoria
city: East Melbourne
country: Australia
facility: Epworth Freemasons
state: Victoria
city: Fitzroy
country: Australia
facility: St Vincents Hospital Melbourne
state: Victoria
city: Heidelberg
country: Australia
facility: Austin Health
state: Victoria
city: Malvern East
country: Australia
facility: Cabrini Hospital Malvern
state: Victoria
city: Melbourne
country: Australia
facility: The Alfred Hospital
state: Victoria
city: Perth
country: Australia
facility: Royal Perth Hospital
state: Western Australia
city: West Perth
country: Australia
facility: Perth Blood Institute
state: Western Australia
city: Melbourne
country: Australia
facility: La Trobe Regional Hospital
city: Innsbruck
country: Austria
facility: Medizinische Universitatsklinik Innsbruck
city: St Polten
country: Austria
facility: Uk St Poelten
city: Wien
country: Austria
facility: Medical Univeristy Vienna
city: Wien
country: Austria
facility: Hanusch Krankenhaus
city: Wien
country: Austria
facility: Wiener Gesundheitsverbund Klinik Ottakring
city: Anderlecht
country: Belgium
facility: Institut Jules Bordet
city: Brugge
country: Belgium
facility: Az Sint Jan Brugge
city: Gand
country: Belgium
facility: Universitair Ziekenhuis Gent
city: Leuven
country: Belgium
facility: University Hospitals Leuven
city: Barretos
country: Brazil
facility: Hospital de Amor Barretos
city: Blumenau
country: Brazil
facility: Clinica de Oncologia Reichow
city: Botucatu
country: Brazil
facility: Unesp Faculdade de Medicina Da Universidade Estadual Paulista Campus Botucatu
city: Brasilia
country: Brazil
facility: Instituto Dor de Pesquisa E Ensino Distrito Federal
city: Campinas
country: Brazil
facility: Universidade de Campinas Centro de Hematologia E Hemoterapia
city: Caxias do Sul
country: Brazil
facility: Fundacao Universidade de Caxias Do Sul
city: Curitiba
country: Brazil
facility: Centro Integrado de Oncologia de Curitiba Ss Cionc
city: Curitiba
country: Brazil
facility: Hospital Erasto Gaertner
city: Florianopolis
country: Brazil
facility: Centro de Ensino E Pesquisa Em Oncologia de Santa Catarina (Cepen)
city: Niteroi
country: Brazil
facility: Complexo Hospitalar de Niteroi
city: Porto Alegre
country: Brazil
facility: Centro Gaucho Integrado de Oncologia Hospital Mae de Deus
city: Recife
country: Brazil
facility: Instituto Dor de Pesquisa E Ensino Pernambuco
city: Recife
country: Brazil
facility: Instituto Dor de Pesquisa E Ensino
city: Ribeirao Preto
country: Brazil
facility: Hospital Das Clinicas Da Faculdade de Medicina de Ribeirao Preto Usp
city: Rio de Janeiro
country: Brazil
facility: Instituto Americas Ensino, Pesquisa E Inovacao
city: Salvador
country: Brazil
facility: Hospital Sao Rafaelinstituto Dor de Pesquisa E Ensino
city: Salvador
country: Brazil
facility: Ensino E Terapia de Inovacao Clinica Amo Etica
city: Sao Paulo
country: Brazil
facility: Hospital Nove de Julho Dasa
city: Sao Paulo
country: Brazil
facility: Instituto Dor de Pesquisa E Ensino Sao Paulo
city: Sao Paulo
country: Brazil
facility: Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular
city: Sao Paulo
country: Brazil
facility: Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
city: Vitoria
country: Brazil
facility: Hospital Santa Rita de Cassia Afecc
city: Plovdiv
country: Bulgaria
facility: Umhat Svgeorgi Ead
city: Sofia
country: Bulgaria
facility: Acibadem City Clinic Tokuda Umhat Ead, Department of Medical Oncology
city: Sofia
country: Bulgaria
facility: University Multiprofile Hospital For Active Treatment Saint Ivan Rilski
city: Sofia
country: Bulgaria
facility: NHATHD
city: Vancouver
country: Canada
facility: British Columbia Cancer Agency the Vancouver Centre
state: British Columbia
city: St Johns
country: Canada
facility: Newfoundland and Labrador Health Services
state: Newfoundland and Labrador
city: Halifax
country: Canada
facility: Queen Elizabeth Ii Health Sciences Centre
state: Nova Scotia
city: Hamilton
country: Canada
facility: Juravinski Cancer Centre
state: Ontario
city: London
country: Canada
facility: London Health Sciences Centre
state: Ontario
city: Chicoutimi
country: Canada
facility: Ciusss Du Saguenay Lac St Jean
state: Quebec
city: Levis
country: Canada
facility: Centre Integre de Sante Et de Services Sociaux de Chaudiere Appalaches
state: Quebec
city: Montreal
country: Canada
facility: Ciusss de Lest de Lile de Montreal Hopital Maisonneuve Rosemont
state: Quebec
city: SaintJerome
country: Canada
facility: Unite de Recherche Clinique Du Cisss Des Laurentides
state: Quebec
city: Sherbrooke
country: Canada
facility: Ciusss de Lestrie Chus
state: Quebec
city: Quebec
country: Canada
facility: Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic)
city: Wuhu
country: China
facility: The First Affiliated Hospital of Wannan Medical College
state: Anhui
city: Beijing
country: China
facility: Beijing Friendship Hospital, Capital Medical University
state: Beijing
city: Beijing
country: China
facility: Beijing Cancer Hospital
state: Beijing
city: Beijing
country: China
facility: Beijing Friendship Hospital, Capital Medical University(Tongzhou)
state: Beijing
city: Chongqing
country: China
facility: Chongqing Cancer Hospital
state: Chongqing
city: Fuzhou
country: China
facility: Fujian Medical University Union Hospital
state: Fujian
city: Xiamen
country: China
facility: The First Affiliated Hospital of Xiamen University
state: Fujian
city: Foshan
country: China
facility: The First Peoples Hospital of Foshan
state: Guangdong
city: Guangzhou
country: China
facility: Sun Yat Sen University Cancer Center
state: Guangdong
city: Huizhou
country: China
facility: Huizhou Central Peoples Hospital
state: Guangdong
city: Meizhou
country: China
facility: Meizhou People Hospital
state: Guangdong
city: Zhanjiang
country: China
facility: Affiliated Hospital of Guangdong Medical University
state: Guangdong
city: Harbin
country: China
facility: Harbin Medical University Cancer Hospital
state: Heilongjiang
city: Anyang
country: China
facility: Anyang Tumor Hospital
state: Henan
city: Zhengzhou
country: China
facility: Henan Cancer Hospital
state: Henan
city: Wuhan
country: China
facility: Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
state: Hubei
city: Wuhan
country: China
facility: Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology
state: Hubei
city: Changde
country: China
facility: The First Peoples Hospital of Changde City
state: Hunan
city: Nanjing
country: China
facility: Jiangsu Province Hospital
state: Jiangsu
city: Nantong
country: China
facility: Affiliated Hospital of Nantong University
state: Jiangsu
city: Suzhou
country: China
facility: The First Affiliated Hospital of Soochow University
state: Jiangsu
city: Wuxi
country: China
facility: Wuxi Peoples Hospital
state: Jiangsu
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University Branch Donghu
state: Jiangxi
city: Nanchang
country: China
facility: Jiangxi Province Cancer Hospital
state: Jiangxi
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University Branch Xianghu
state: Jiangxi
city: Changchun
country: China
facility: The First Hospital of Jilin University
state: Jilin
city: Shenyang
country: China
facility: Shengjing Hospital of China Medical University
state: Liaoning
city: Shenyang
country: China
facility: Liaoning Cancer Hospital and Institute
state: Liaoning
city: Rizhao
country: China
facility: Peoples Hospital of Rizhao
state: Shandong
city: Taian
country: China
facility: The Second Affiliated Hospital of Shandong First Medical University
state: Shandong
city: Shanghai
country: China
facility: Fudan University Shanghai Cancer Center
state: Shanghai
city: Taiyuan
country: China
facility: Shanxi Provincial Cancer Hospital
state: Shanxi
city: Chengdu
country: China
facility: West China Hospital, Sichuan University
state: Sichuan
city: Dongyang
country: China
facility: Dongyang Peoples Hospital
state: Zhejiang
city: Hangzhou
country: China
facility: Zhejiang Cancer Hospital
state: Zhejiang
city: Jiaxing
country: China
facility: The First Hospital of Jiaxing
state: Zhejiang
city: Jinhua
country: China
facility: Jinhua Municipal Central Hospital
state: Zhejiang
city: Wenzhou
country: China
facility: The First Affiliated Hospital of Wenzhou Medical University
state: Zhejiang
city: Hradec Kralove
country: Czechia
facility: Fakultni Nemocnice Hradec Kralove
city: Olomouc
country: Czechia
facility: Fakultni Nemocnice Olomouc
city: Antony
country: France
facility: Hopital Prive Dantony, Departement Dhemathologie
city: Le Mans
country: France
facility: Centre Hospitalier Le Mans
city: Montpellier
country: France
facility: Chu Montpellier Hopital Saint Eloi
city: Nice
country: France
facility: Hopital Larchet Chu Nice
city: Paris
country: France
facility: Institut Curie
city: Paris
country: France
facility: Necker University Hospital
city: Strasbourg
country: France
facility: Icans Institut de Cancerologie Strasbourg Europe
city: VandoeuvrelesNancy
country: France
facility: Chu Nancy Hopital Brabois
city: Batumi
country: Georgia
facility: High Technology Hospital Medcenter Ltd
city: Kutaisi
country: Georgia
facility: JSC VIAN
city: Tbilisi
country: Georgia
facility: K Eristavi National Center of Experimental and Clinical Surgery Jsc
city: Tbilisi
country: Georgia
facility: Oncology Research Center Ltd
city: Essen
country: Germany
facility: Universitaetsklinikum Essen
city: Ulm
country: Germany
facility: Universitaetsklinikum Ulm
city: Alexandroupolis
country: Greece
facility: University Hospital of Alexandroupolis
city: Athens
country: Greece
facility: Evaggelismos
city: Athens
country: Greece
facility: General Hospital of Athens Alexandra
city: Patras
country: Greece
facility: University Hospital of Patra
city: Dublin
country: Ireland
facility: St Jamess Hospital
city: Waterford
country: Ireland
facility: University Hospital Waterford
city: Afula
country: Israel
facility: Haemek Medical Center
city: Ashdod
country: Israel
facility: Assuta Ashdod Medical Center
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
city: Jerusalem
country: Israel
facility: Hadassah En Karem Medical Center
city: Petach Tikva
country: Israel
facility: Rabin Medical Center
city: Ramat gan
country: Israel
facility: Chaim Sheba Medical Center
city: Tel Aviv Jaffa
country: Israel
facility: Assuta Medical Center
city: Tel Aviv Jaffa
country: Israel
facility: Sourasky Tel Aviv Medical Center
city: Aviano
country: Italy
facility: Cro Irccs Aviano
city: Bologna
country: Italy
facility: Irccs Azienda Ospedaliero Universitaria Bologna
city: Firenze
country: Italy
facility: Aou Careggi, Servizio Sanitario Toscana
city: Milano
country: Italy
facility: Istituto Europeo Di Oncologia
city: Milano
country: Italy
facility: Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
city: Novara
country: Italy
facility: Aou Maggiore Della Carita
city: Padova
country: Italy
facility: Azienda Ospedaliera Di Padova
city: Pavia
country: Italy
facility: Irccs Policlinico San Matteo, Universita Degli Studi Di Pavi
city: Reggio Emilia
country: Italy
facility: Arcispedale S Maria Nuova Ausl Reggio Emilia Hematology Unit
city: Udine
country: Italy
facility: Aou Santa Maria Della Misericordia Di Udine
city: Varese
country: Italy
facility: Ospedale Di Circolo E Fondazione Macchi
city: Nagoya
country: Japan
facility: Aichi Cancer Center Hospital Clinical Oncology
state: Aichi
city: Matsuyamashi
country: Japan
facility: Matsuyama Red Cross Hospital
state: Ehime
city: Hiroshimashi
country: Japan
facility: Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital
state: Hiroshima
city: SapporoShi
country: Japan
facility: National Hospital Organization Hokkaido Cancer Center
state: Hokkaido
city: SapporoShi
country: Japan
facility: Aiiku Hospital
state: Hokkaido
city: Yokohamashi
country: Japan
facility: Kanagawa Cancer Center
state: Kanagawa
city: KyotoShi
country: Japan
facility: University Hospital, Kyoto Prefectural Univ of Medicine
state: Kyoto
city: Sendaishi
country: Japan
facility: Tohoku University Hospital
state: Miyagi
city: Kurashikishi
country: Japan
facility: Kurashiki Central Hospital
state: Okayama
city: Hirakata
country: Japan
facility: Kansai Medical University Hospital
state: Osaka
city: Osakasayama
country: Japan
facility: Kindai University Hospital
state: Osaka
city: Bunkyoku
country: Japan
facility: Tokyo Metropolitan Komagome Hospital
state: Tokyo
city: ChuoKu
country: Japan
facility: National Cancer Center Hospital
state: Tokyo
city: Kotoku
country: Japan
facility: Cancer Institute Hospital of Jfcr
state: Tokyo
city: Yamagatashi
country: Japan
facility: Yamagata University Hospital
state: Yamagata
city: Kumamoto
country: Japan
facility: Kumamoto University Hospital
city: Okayama
country: Japan
facility: National Hospital Organization Okayama Medical Center
city: YokohamaShi
country: Japan
facility: Yokohama Municipal Citizens Hospital
city: BusanjinGu
country: Korea, Republic of
facility: Inje University Busan Paik Hospital
state: Busan Gwang'yeogsi
city: SeoGu
country: Korea, Republic of
facility: Dong A University Hospital
state: Busan Gwang'yeogsi
city: SeoGu
country: Korea, Republic of
facility: Pusan National University Hospital
state: Busan Gwang'yeogsi
city: BundangGu SeongnamSi
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyeonggi-do
city: BukGu
country: Korea, Republic of
facility: Kyungpook National University Chilgok Hospital
state: Gyeongsangbukdo
city: JinjuSi
country: Korea, Republic of
facility: Gyeongsang National University Hospital
state: Gyeongsangnamdo
city: HwasunGun
country: Korea, Republic of
facility: Chonnam National University Hwasun Hospital
state: Jeollanam-do
city: GangnamGu
country: Korea, Republic of
facility: Samsung Medical Center
state: Seoul Teugbyeolsi
city: SeochoGu
country: Korea, Republic of
facility: The Catholic University of Korea, Seoul St Marys Hospital
state: Seoul Teugbyeolsi
city: SeodaemunGu
country: Korea, Republic of
facility: Severance Hospital Yonsei University Health System
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
state: Seoul Teugbyeolsi
city: SongpaGu
country: Korea, Republic of
facility: Asan Medical Center
state: Seoul Teugbyeolsi
city: YongsanGu
country: Korea, Republic of
facility: Soon Chun Hyang University Hospital Seoul
state: Seoul Teugbyeolsi
city: Bydgoszcz
country: Poland
facility: Szpital Uniwersytecki Nr Im Dr Jana Biziela
city: Gdask
country: Poland
facility: Uniwersyteckie Centrum Kliniczne Klinika Hematologii I Transplantologii
city: Katowice
country: Poland
facility: Pratia Onkologia Katowice
city: Krakow
country: Poland
facility: Pratia McM Krakow
city: Poznan
country: Poland
facility: Uniwersytecki Szpital Kliniczny W Poznaniu, Oddzial Hematologii I Transplantacji Szpiku
city: Torun
country: Poland
facility: Wojewodzki Szpital Zespolony Im L Rydygiera W Toruniu
city: Warszawa
country: Poland
facility: Centralny Szpital Kliniczny Uck Wum
city: Warszawa
country: Poland
facility: Instytut Hematologii I Transfuzjologii
city: Warszawa
country: Poland
facility: Narodowy Instytut Onkologii Im Marii Skodowskiej Curie Hematology Unit
city: Braga
country: Portugal
facility: Hospital de Braga
city: Porto
country: Portugal
facility: Instituto Portugues de Oncologia Do Porto Francisco Gentil, Epe
city: VILA NOVA DE GAIA Porto
country: Portugal
facility: Unidade Local de Saude Gaia E Espinho
city: San Juan
country: Puerto Rico
facility: Auxilio Mutuo Cancer Center
city: Bucharest
country: Romania
facility: Coltea Clinical Hospital
city: ClujNapoca
country: Romania
facility: Institutul Oncologic Prof Dr Ion Chiricuta Cluj Napoca
city: Iasi
country: Romania
facility: Institutul Regional de Oncologie Iasi
city: Oradea
country: Romania
facility: Spitalul Clinic Judetean de Urgenta Bihor
city: Cape Town
country: South Africa
facility: University of Cape Town
city: Kuils River
country: South Africa
facility: Haemalife
city: Pretoria
country: South Africa
facility: Alberts Cellular Therapy
city: Badalona
country: Spain
facility: Ico Badalona
city: Burgos
country: Spain
facility: Hospital Universitario de Burgos
city: Cadiz
country: Spain
facility: Hospital Universitario Puerta Del Mar
city: Granada
country: Spain
facility: Hospital Universitario Virgen de Las Nieves
city: Hospitalet de LLobregat
country: Spain
facility: Institut Catala Doncologia Hospital Duran I Reynals
city: Leon
country: Spain
facility: Complejo Asistencial Universitario de Leon
city: Madrid
country: Spain
facility: Hospital de La Princesa
city: Madrid
country: Spain
facility: Clinica Universidad de Navarra
city: Madrid
country: Spain
facility: Hospital Universitario Infanta Leonor
city: Madrid
country: Spain
facility: Hospital Universitario Ramon Y Cajal
city: Majadahonda
country: Spain
facility: H Puerta de Hierro Majadahonda
city: Murcia
country: Spain
facility: Hospital Clinico Universitario Virgen de La Arrixaca
city: Pamplona
country: Spain
facility: Clinica Universidad de Navarra Pamplona
city: Pozuelo de Alarcon
country: Spain
facility: Hospital Universitario Quironsalud Madrid
city: Salamanca
country: Spain
facility: Hospital Universitario de Salamanca
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Del Rocio
city: Terrassa
country: Spain
facility: Hospital Universitari Mutua Terrassa
city: Basel
country: Switzerland
facility: St Claraspital
city: Fribourg
country: Switzerland
facility: Hfr Fribourg
city: La ChauxdeFonds
country: Switzerland
facility: Reseau Hospitalier Neuchatelois
city: Zurich
country: Switzerland
facility: Universitatsspital Zurich
city: Ankara
country: Turkey
facility: Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
city: Ankara
country: Turkey
facility: Ankara University Medical Faculty
city: AOCiftlii
country: Turkey
facility: Gazi University Medical School
city: Atakum Samsun
country: Turkey
facility: Ondokuz Mayis University Medicine Faculty Hospital
city: Balcova
country: Turkey
facility: Dokuz Eylul University
city: Istanbul
country: Turkey
facility: Bagcilar Medipol Mega Hospital
city: Kocaeli
country: Turkey
facility: Kocaeli Universitesi Tip Fakultesi
city: Tevikiye
country: Turkey
facility: Vkv American Hospital
city: Glasgow
country: United Kingdom
facility: Beatson West of Scotland Cancer Centre
city: Greater Manchester
country: United Kingdom
facility: The Christie Hospital
city: Huddersfield
country: United Kingdom
facility: Huddersfield Royal Infirmary
city: Inverness
country: United Kingdom
facility: Nhs Highland
city: Leeds
country: United Kingdom
facility: The Leeds Teaching Hospitals Nhs Trust
city: London
country: United Kingdom
facility: Barts Health Nhs Trust
city: London
country: United Kingdom
facility: University College Hospital
city: Plymouth
country: United Kingdom
facility: Derriford Hospital
city: Southampton
country: United Kingdom
facility: Southampton General Hospital
Study officials:
affiliation: BeiGene
name: Study Director
role: STUDY_DIRECTOR
affiliation: BeiGene
name: Study Director
role: PRINCIPAL_INVESTIGATOR
References: