Clinical trial NCT05058001: Diagnosis Of Neurological Fetal Anomalies
Official title: Accuracy of Prenatal Ultrasonography in The Diagnosis Of Neurological Fetal Anomalies
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Fetal Anomaly of Central Nervous System
Keywords: Sonography ,neurlogical anomalies
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2021-09-27
Enrollment: 300
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: 300 pregnant women have mid anatomical scan at 20-22 weeks as routine antenatal care and Examination of the fetal CNS will be performed with a high resolution two dimintional ultrasound machine (Voluson E8) equipped with a RAB 4 to 8MHz multifrequency transabdominal Probe.

Brief summary: This is a descriptive cross-sectional study 300 patients coming for antenatal care at sohag governorate undergo mid anatomical scan.

Samples 300 pregnant women have mid anatomical scan at 20-22 weeks as routine antenatal care and Examination of the fetal CNS will be performed with a high resolution two dimensional ultrasound machine (Voluson E8) equipped with a RAB 4 to 8MHz multifrequency transabdominal Probe. Four standard recommended views-transventricular, falx, cavum, and posterior fossa or transcerebellar views-provide an overview of fetal intracranial anatomy during the second trimester anatomy scan.

Follow-up information will be obtained in all cases, and all infants will be considered healthy by pediatric examination. In selected cases, postnatal single-shot fast spin-echo magnetic resonance (MR) imaging will be performed as integrated, complementary investigation.to confirm diagnosis.

Detailed description: 1. Type of the study: This is a descriptive cross-sectional study
2. Study Setting: 300 patients coming for antenatal care at sohag governorate undergo routine second trimester scan.
3. patients and methods:

Inclusion criteria:

1. All pregnant females of 18 to 45 years old.
2. gestational age of 20- 22 gestational week .

Exclusion criteria:

1-age less than18years and more than 45 years. gestational age less or more than20- 22 weeks. Samples Methods 300 pregnant women low risk pregnancy will be scanned at 20-22 weeks as routine antenatal care and Examination of the fetal CNS will be performed with a high resolution two dimintional ultrasound machine (Voluson E8) equipped with a RAB 4 to 8MHz multifrequency transabdominal Probe. Four standard recommended views-transventricular, falx, cavum, and posterior fossa or transcerebellar views-provide an overview of fetal intracranial anatomy during the second trimester anatomy scan.

Follow-up information will be obtained in all cases, and all infants will be considered healthy by pediatric examination. In selected cases, postnatal single-shot fast spin-echo magnetic resonance (MR) imaging will be performed as integrated, complementary investigation.to confirm diagnosis.

Eligibility criteria: Inclusion Criteria:

* All pregnant females of 18 to 45 years old.
* gestatioal age of 20- 22 gestational week .

Exclusion Criteria:

* age less than18years and more than 45 years.
* gestational age less or more than20- 22 weeks.

Primary outcomes:
measure: Accuracy of sonography in the diagnosis of neurological fetal anomalies
timeFrame: From 20 _ 22 gestational age ...confirmation occursat birth till 1 week post natal
Secondary outcomes:
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Medicine
state: سوهاج
Study officials:
affiliation: Sohag University
name: Bothyna Za Elsayed, Assistant lecturer
role: PRINCIPAL_INVESTIGATOR
References: