Clinical trial NCT02073630: Contribution of the Cerebellum In Sensory-motor Adaptation Via Gamma Oscillations: the Case of Dystonia
Official title: Contribution du Cervelet Dans l'Adaptation Sensori-motrice Via Les Oscillations Gamma : le Cas de la Dystonie
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Primary Dystonia
Keywords: magnetoencephalography
non invasive brain stimulation
cerebellum
gamma rhythms
Lead sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Sponsor class: OTHER_GOV
First posted: 2014-02-27
Enrollment: 63
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Dystonia, a disabling disease with uncontrolled movement disorders was considered to be a manifestation of basal ganglia dysfunction, yet there is accumulating evidence from animal and human experiments that the cerebellum plays a prominent role in the pathophysiology of dystonia. Our recent results suggest a deficient cerebellar sensory encoding in dystonia, resulting in a decoupling of the motor component from the afferent information flow resulting from changes in the environment. An overall loss of gabaergic-mediated inhibition is at the forefront in dynamic changes in neural circuitry described in dystonia. In the mature brain gabaergic control the generation of temporal synchronies and oscillations in the glutamatergic neurons. Taken these all together with the results of a pilot experiment, the investigators hypothesize that deficient synchronies in the fast gamma range are one of the key mechanisms leading to abnormal communication inside the cerebello-cortical network in dystonia. The investigators aim first to demonstrate it by means of MEG (Magneto encepholography) recordings allowing to reconstruct the spatio-temporal dynamics of gamma oscillations in the nodes of the cerebello-cortical network. The investigators then aim to re-establish (if lost) or boost (if decreased) the defective synchronies by applying to the cerebellum at high gamma frequency a non invasive transcranial alternative current stimulation.


Eligibility criteria: Inclusion Criteria:

* primary upper limb dystonia
* normal physical and neurological examination except for dystonia
* no treatment with botulinum toxin during the three months preceding the study

Exclusion Criteria:

* Writing tremor
* current neurological or psychiatric illness other than dystonia
* uncontrollable medical problems not related to dystonia
* pregnancy, breast feeding women and women who are of childbearing age and not practicing adequate birth control

Primary outcomes:
measure: change in gamma oscillations power in the cerebellum during a sensorimotor adaptation task
timeFrame: measures will be done at each of 3 visits: visit1, visit2 at expected average 7 days after visit1 and visit3 at expected average 14 days after visit1
Secondary outcomes:
measure: synchrony in the gamma band between the cerebellum and the sensorimotor cortex
timeFrame: measures will be done at each of 3 visits: visit1, visit2 at expected average 7 days after visit1 and visit3 at expected average 14 days after visit1
Other outcomes:
measure: behavioral performances at a sensorimotor adaptation task
timeFrame: measures will be done at each of 3 visits: visit1, visit2 at expected average 7 days after visit1 and visit3 at expected average 14 days after visit1
Locations:
city: Paris
country: France
facility: ICM GH Pitié Salpetrière
Study officials:
affiliation: Institut National de la Santé Et de la Recherche Médicale, France
name: sabine meunier, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: