louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04283357: Comparison Of Effects Virtual Reality and Short Foot Exercises On Balance and Performance in Pes Planus
Official title: Effect of Virtual Reality on Pes Planus
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Virtual Reality
Keywords: virtual reality
foot posture
navicular drop
short foot exercise
Lead sponsor: Hacettepe University
Sponsor class: OTHER
Collaborators: name: Kırıkkale University
First posted: 2020-02-25
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: One group only are treated with short foot exercises. Second group are treated with short foot exercises and virtual reality.
Primary purpose: TREATMENT

Brief summary: Virtual reality exercises have become increasingly popular in recent years. After the increase in usage areas in daily life, its use in healthcare has become widespread. Flatfoot is one of the orthopedic problems with high prevalence, especially in young individuals. In the literature, conservative treatment methods of flat soles are mentioned as exercise, shoe modifications, and orthotic methods. In the study, it is planned to investigate whether individuals with flat-footed virtual reality exercises contribute to conservative treatment.

The aim of this study was to investigate the effect of virtual reality exercises on individuals with pes planus.

Detailed description: To show whether virtual reality exercises will contribute to decrease of flat footing, improvement of balance and increase of performance of individuals with flat foot.

Eligibility criteria: Inclusion Criteria:

* Have pes planus,
* Volunteer for this study,
* Climb 10 stairs independently,
* Can stand one single leg

Exclusion Criteria:

* History of trauma, fracture or operation of the foot, knee, and hip that will affect the foot
* Having visual, hearing and mental problems that prevent participation in virtual reality exercises,
* Being diagnosed with orthopedic or neurological problems that prevent standing on a single leg

Primary outcomes:
measure: comparison of exercise and virtual reality treatment on balance
timeFrame: 15 minute
Secondary outcomes:
measure: Effect of exercise on performance
timeFrame: 10 minute
measure: Navicular Drop Test
timeFrame: 5 minute
measure: Femoral anteversion test
timeFrame: 5 minute
Other outcomes:
Locations:
city: Kırıkkale
country: Turkey
facility: Kırıkkale University
state: Yahşihan
Study officials:
affiliation: Kırıkkale University
name: Cevher Demirci, Dr
role: STUDY_DIRECTOR
References:
citation: Yildirim Sahan T, Aydogan Arslan S, Demirci C, Oktas B, Sertel M. Comparison Of Short-Term Effects Of Virtual Reality and Short Foot Exercises In Pes Planus. Foot (Edinb). 2021 Jun;47:101778. doi: 10.1016/j.foot.2021.101778. Epub 2021 Jan 21.
Clinical trial NCT02079857: Symptom Management for Irritable Bowel Syndrome
Official title: Symptom Management for Irritable Bowel Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Irritable Bowel Syndrome
Lead sponsor: NYU Langone Health
Sponsor class: OTHER
Collaborators: name: National Institute of Nursing Research (NINR)
First posted: 2014-03-06
Enrollment: 183
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this study is to test the efficacy of a symptom management treatment strategy, Acupuncture/Moxibustion (Acu/Moxa), to improve the symptoms associated with Irritable Bowel Syndrome (IBS) in adults.


Eligibility criteria: Inclusion Criteria:

* Men and women 18 to 70 years of age.
* Diagnosis of IBS based on ROME III criteria.
* Complete symptom diaries and return completed diaries at all sessions.

Exclusion Criteria:

* History of co-existing gastrointestinal, and/or gynecological, and/or urologic pathology.
* Alarm symptoms according to ROME III.
* Individuals currently receiving other types of complementary therapies.
* Individuals with an acute medical condition requiring acute medical attention.

Primary outcomes:
measure: Symptom severity-abdominal pain
timeFrame: week 1
measure: Symptom severity-abdominal pain
timeFrame: week 4
measure: Symptom severity-abdominal pain
timeFrame: week 8
measure: Symptom severity-abdominal pain
timeFrame: week 12
measure: Symptom severity-abdominal pain
timeFrame: week 24
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: NYU Division of Special Studies in Symptom Management
state: New York
Study officials:
affiliation: New York University
name: Joyce K Anastasi, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03416257: TMAO and Atherosclerosis in HIV
Official title: Gut Microbial-related Choline Metabolite Trimethylamine-N-oxide is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Carotid Artery Plaque
Lead sponsor: Albert Einstein College of Medicine
Sponsor class: OTHER
Collaborators: name: National Heart, Lung, and Blood Institute (NHLBI)
First posted: 2018-01-31
Enrollment: 737
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A total of 737 women and men with available baseline plasma choline metabolite data were included in this analysis. There were 520 HIV-infected (291 women, 229 men) and 217 HIV-uninfected (107 women, 110 men) participants included in this study. Baseline characteristics are shownin Table 1. HIV-infected and HIV-uninfected participants were generally similar in terms of demographic and behavioral variables, although HIV-infected participants were more likely to have a history of HCV infection. In addition, HIV-infected participants had lower total cholesterol and HDL cholesterol levels compared to those without HIV infection. The majority of HIV-infected individuals reported using potent ART at baseline (74% in women and 83% in men), and 46% of women and 66% of men had undetectable HIV-1 viral load (≤80 copies/mL). Compared to men, women were younger, more likely to be of black race or Hispanice thnicity and current smokers, and have a history of HCV infection and higher BMI.

Brief summary: In the present study, the investigators sought to prospectively examine the associations of plasma levels of TMAO (trimethylamine oxide), choline, betaine, dimethylglycine, and sarcosine with risk of incident carotid artery plaque, assessed by repeated B-mode carotid artery ultrasound imaging over a 7-year period, in women and men with and without HIV infection from the WIHS (Women Interagency HIV Study) and MACS (Multicenter Aids Cohort Study).


Eligibility criteria: Inclusion Criteria:

* participants who underwent carotid artery imaging for plaque assessment at a baseline visit (2004-2006) and at a follow-up visit (2011-2013).

Exclusion Criteria:

* a history of coronary heart disease, individuals with prevalent diabetes or prevalent carotid artery plaques at baseline

Primary outcomes:
measure: incident carotid artery plaque
timeFrame: 2011-2013
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02871557: Frailty and the Elderly in Martinique
Official title: Frail Elderly Subjects Martinique: Adverse Outcome After Hospitalisation in Geriatric Department
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Elderly People With Polypathology or Disabilities
Lead sponsor: Société Martiniquaise de Gérontologie et Gériatrie
Sponsor class: OTHER
Collaborators: name: CHU de Reims
First posted: 2016-08-18
Enrollment: 287
Sex: ALL
Minimum age (years): 75
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A group of elderly people hospitalised in acute care for elders

Brief summary: This was a prospective multicenter cohort study of elderly people admitted to the acute care for elders in Martinique. They were followed up to 36 months. It aimed to study the adverse outcomes. In all, 287 subjects were included. They were 85+/-6 years, and mainly women (61%).

Detailed description: The SAFMA cohort was an ad hoc study formed into the recruitment of the acute care for elders in the geriatric department of Martinique university Hospitals. The inclusion of subjects ran from January 1st 2012 to June 30th 2012. To be eligible, patients had to be 75 or over and hospitalised for acute condition. Each patient was visited by a specialist in geriatrics familiar with the survey procedures. In the course of this interview, patients were informed about the study, prior to signing the consent form. If the clinical status and/or the cognitive status of the patient did not enable informed consent, the interviewer referred to the subject's representative. Follow-up was performed by visits and telephone interview till 36 months.

Eligibility criteria: Inclusion Criteria:

* Age of 75 years or over
* Admitted to acute care for elders
* Consent to participate

Exclusion Criteria:

* Impossibility to perform the tests
* Refusals to participate

Primary outcomes:
measure: Mortality
timeFrame: 6 weeks
measure: Nursing home admission
timeFrame: 6 weeks
Secondary outcomes:
measure: Mortality
timeFrame: 6 month
measure: Mortality
timeFrame: 12 month
measure: Mortality
timeFrame: 24 month
measure: Mortality
timeFrame: 36 month
measure: Nursing home admission
timeFrame: 6 month
measure: Nursing home admission
timeFrame: 12 month
measure: Nursing home admission
timeFrame: 24 month
measure: Nursing home admission
timeFrame: 36 month
Other outcomes:
Locations:
Study officials:
References:
citation: Godard-Sebillotte C, Drame M, Basileu T, Fanon JL, Godaert L. Is self-rated health an independent prognostic factor of six-week mortality in older patients hospitalized for an acute condition? Qual Life Res. 2016 Sep;25(9):2335-40. doi: 10.1007/s11136-016-1252-3. Epub 2016 Feb 26.
Clinical trial NCT06531057: Determination Of Factors Affecting Mobility
Official title: Determination Of Factors Affecting Mobility In Patients Undergoing Abdominal Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Surgery
Keywords: postoperative care
Mobilization
Surgical Nursing
Lead sponsor: Sanko University
Sponsor class: OTHER
First posted: 2024-07-31
Enrollment: 152
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The population of the study consisted of 236 patients who underwent cholecystectomy, appendectomy, hernia surgery and bariatric surgery in the general surgery clinic of the specified hospital on the dates of data collection. Among these patients, 152 patients who met the sampling criteria and volunteered to participate in the study were included in the sample.

Brief summary: This descriptive study was conducted to determine the factors affecting mobility in patients undergoing abdominal surgery.

Detailed description: Surgical factors that may affect the mobility of patients undergoing abdominal surgery should be examined, as well as individual characteristics and characteristics related to the postoperative period. If nurses know about the factors that may affect the patient's mobility after surgery, this may be helpful in effectively managing these factors in clinics and encouraging the patient to be more active.

This study was conducted to determine the mobility of patients who underwent abdominal surgery in the early postoperative period and the factors affecting mobility.

Eligibility criteria: Inclusion Criteria:

* • had no chronic pain or no visual or hearing impairment,

  * were 18 years of age or older,
  * were conscious after surgery,
  * had walked for the first time in the patient room after the surgery according to the clinical routine,
  * were voluntary to participate in the study.

Exclusion Criteria:

Fifty four patients who did not speak Turkish and 28 patients who failed to walk for the first time after surgery were excluded from the study.

Primary outcomes:
measure: Patient Mobility Scale
timeFrame: at day 1
Secondary outcomes:
measure: Observer Mobility Scale
timeFrame: at day 1
measure: Questionnaire for Factors Affecting Movement
timeFrame: at day 1
Other outcomes:
Locations:
city: Şehitkamil
country: Turkey
facility: Ebru Karaaslan
state: Gazi̇antep
Study officials:
References:
Clinical trial NCT01657357: Routine Follow up After Total Hip Arthroplasty Prior Periacetabular Osteotomy
Official title: Routine Follow up After THA in PAO Patient
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hip Dysplasia
Osteotomy of Pelvis
Total Hip Arthroplasty
Lead sponsor: University of Aarhus
Sponsor class: OTHER
First posted: 2012-08-06
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients, who despite a joint preserving procedure(periacetabular osteotomy PAO) ended up with a total hip arthroplasty (THA).

Brief summary: Follow up study of patients, who despite periacetabular osteotomy, need a total hip arthroplasty, to see outcome.


Eligibility criteria: Inclusion Criteria:

* PAO and THA

Exclusion Criteria:

* time since THA less than 4 yrs

Primary outcomes:
measure: Does previous PAO compromise the function of a secondary THA
timeFrame: Up to 10 years after THA surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Aarhus
country: Denmark
facility: Orthopaedic department, Aarhus Universityhospital
Study officials:
affiliation: Orthopedic Research Unit, Aarhus University Hospital
name: Kjeld Soballe, Prof. D.Msc
role: STUDY_CHAIR
affiliation: Orthopedic Research Unit, Aarhus University Hospital
name: Charlotte Hartig-Andreasen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01389557: Impact of Dihydroartemisinin-piperaquine Plus Primaquine on Malaria Transmission in Lampung Province, Sumatra
Official title: Evaluation of Impact Dihydroartemisinin-piperaquine Plus Primaquine on Malaria Transmission in Lempasing Village, Lampung Province, Southern Sumatra
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Malaria
Keywords: malaria
DHP
PQ
MST
Lead sponsor: Indonesia University
Sponsor class: OTHER
First posted: 2011-07-08
Enrollment: 77
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Artemisinin-based combination therapy (ACT) has been known to be controversial for stopping malaria transmission. The addition of primaquine (PQ) - the only drug commercially available that kills mature transmission stage - to such treatments might be necessary to eliminate this stage. A study is conducted to evaluate the efficacy of dihydroartemisinin-piperaquine (DHP) regimens with PQ on malaria transmission on a community wide level in Lempasing, Lampung, Sumatra.

Detailed description: A mass screening baseline survey enabled the description of malaria prevalence (P. falciparum and P. vivax). Malaria infected asymptomatic (from the mass screening) and symptomatic (malaria infected people attending the health center) people were enrolled in the study. Enrolled malaria infected subjects were treated with DHP and PQ according to the treatment regimen. The community was mass screened for malaria infections every 3 months and an incidence cohort screened every month for infections. The 3 aims were to look at malaria antibodies, haemoglobin levels and the incidence of malaria before and after the drug intervention.

Eligibility criteria: Inclusion Criteria:

* All individuals residing Lempasing village, kecamatan Hanura, Lampung province during study period

Exclusion Criteria:

* Individuals with severe or chronic disease (liver, kidney), infant and pregnant or breastfeeding woman
* Individuals that refuse to sign informed consent are excluded.
* normal glucose-6-phosphate dehydrogenase enzyme level based on qualitative test (Trinity Biotech® no 203, USA)
* willingness to sign the informed-consent form

Primary outcomes:
measure: Presence of malaria (P. falciparum and P. vivax) parasites in blood spot
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Lampung
country: Indonesia
facility: Inge Sutanto, Hanura Primary Health Center
state: Sumatra
Study officials:
affiliation: Univesity of Indonesia
name: Inge Sutanto, Md PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00245557: Magnetic Resonance Imaging Study of Geriatric Depression
Official title: Nuclear Magnetic Resonance Imaging Study of Treatment With Sertraline in Geriatric Depression
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Major Depressive Disorder
Keywords: Depression
Geriatric
MRI
Sertraline
Lead sponsor: Mclean Hospital
Sponsor class: OTHER
Collaborators: name: Pfizer
name: National Alliance for Research on Schizophrenia and Depression
First posted: 2005-10-28
Enrollment: 43
Sex: ALL
Minimum age (years): 55
Maximum age (years): 89
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study was to use Magnetic Resonance Images to further our understanding of predictors and markers of treatment response and non-response in geriatric depression. We hypothesized that concentrations of high energy metabolites would be lower in depressed elderly compared to non-depressed.


Eligibility criteria: Inclusion Criteria:

* DSM- IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) diagnostic criteria for major depressive disorder
* Hamilton Depression Scale- 17 item version score of 18 or higher
* Must speak English
* Women must be post-menopausal

Exclusion Criteria:

* A current or pervious psychiatric disorder other than MDD
* A current unstable medical condition
* A pacemaker or metal implant
* History of alcohol or drug dependence or abuse within the past year
* Current prescription of excluded medications
* Use of a drug within the last 30 days that was not approved for use by governmental authorities.
* If you or a family member works at McLean Hospital

Primary outcomes:
measure: HAM-D 17 (Hamilton Depression Rating Scale)
timeFrame: baseline at study entry week 0
measure: Geriatric Depression Scale
timeFrame: baseline at study entry week 0
measure: Phosphorus Magnetic Resonance Spectroscopy (31P-MRS)
timeFrame: at week 0 for both control and depressed, and at week 12 for depressed
Secondary outcomes:
Other outcomes:
Locations:
city: Belmont
country: United States
facility: McLean Hospital
state: Massachusetts
Study officials:
affiliation: Mclean Hospital
name: Brent Forester, M.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Harper DG, Joe EB, Jensen JE, Ravichandran C, Forester BP. Brain levels of high-energy phosphate metabolites and executive function in geriatric depression. Int J Geriatr Psychiatry. 2016 Nov;31(11):1241-1249. doi: 10.1002/gps.4439. Epub 2016 Feb 18.
Clinical trial NCT06853457: A Transfer Learning Radiomics Model for Predicting Response to Initial Transarterial Embolization in Patients with Gastroenteropancreatic Neuroendocrine Tumor Liver Metastases
Official title: A Transfer Learning Radiomics Model for Predicting Response to Initial Transarterial Embolization in Patients with Gastroenteropancreatic Neuroendocrine Tumor Liver Metastases: from Lesion-targeted to Patient-targeted Prediction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Neuroendocrine Tumors, NET
Lead sponsor: First Affiliated Hospital, Sun Yat-Sen University
Sponsor class: OTHER
First posted: 2025-03-03
Enrollment: 257
Sex: ALL
Minimum age (years): 18
Maximum age (years): 78
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: This study retrospectively included gastroenteropancreatic neuroendocrine tumors liver metastasis patients who receive initial transarterial embolization from January 2014 to September 2022 at The First Affiliated Hospital of Sun Yat-sen University.

Brief summary: To develop and validate a CT-based transfer learning radiomics model for predicting response to initial TAE in GEP-NETLM patients and compare its performance with traditional radiomics and clinical models.


Eligibility criteria: Inclusion Criteria:

* (a) Clinical diagnosed as gastroenteropancreatic neuroendocrine tumor liver metastases; (b) Received initial transarterial embolization therapy; (c) Underwent multi-phase ceCT scans pre-TAE (≤1 month) and post-TAE (4-6 weeks).

Exclusion Criteria:

* (a) Neuroendocrine carcinoma (NEC) or other malignancies. (b) Received other liver metastasis treatments. (c) Lack of Multi-phase ceCT scans records. (d) CT images with artifacts or no visible lesions.

Primary outcomes:
measure: The efficacy of TAE
timeFrame: Within one month prior and 4-6 weeks following the initial TAE.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: