Clinical trial NCT05817357: Use of Air Purifiers to Improve Respiratory Health in Children
Official title: Use of Air Purification Devices in the Homes of Children and Young People to Improve Respiratory Health - a Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Asthma in Children
Lead sponsor: University of Liverpool
Sponsor class: OTHER
First posted: 2023-04-18
Enrollment: 20
Sex: ALL
Minimum age (years): 5
Maximum age (years): 15
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The goal of this pilot study is to investigate if installing an air purifier in the homes of children and young people with asthma improves their asthma outcomes.

The main questions it aims to answer are:

* Does installing an air purifier in the homes of children and young people with asthma improve their asthma outcomes
* Is the use of an air purifier in the home acceptable to children and young people and their families?

Children and young people with asthma attending our clinic will be selected at random to be invited to take part. For those that take part, an air purifier (Rensair Ltd. - Rensair Compact) will be installed in their home for a one-year period. Data will be collected on numbers of asthma attacks, rescue oral steroids, quality of life, symptoms, lung function at the beginning and at three-monthly intervals throughout the study period. The acceptability to children and young people and their families taking part in this study of using an air purifier in their home will also be assessed.

Detailed description: The goal of this pilot study is to investigate if installing an air purifier in the homes of children and young people with asthma improves their asthma outcomes.

The main questions it aims to answer are:

* Does installing an air purifier in the homes of children and young people with asthma improve their asthma outcomes (including reduction in asthma exacerbations, improvement in symptom control, improvement in quality of life).
* Is the use of an air purifier in the home acceptable to children and young people and their families?

Eligibility criteria: Inclusion Criteria:

* Aged 5 to 15 years old
* Attend the asthma clinic in our hospital
* Have a confirmed physician-diagnosis of asthma from the asthma clinic
* Live in mainland England (this is due to delivery of the air purification units and also associated maintenance of them)

Exclusion Criteria:

* Nil specific other than not meeting inclusion criteria

Primary outcomes:
measure: Number of asthma exacerbations (asthma attacks)
timeFrame: 12 months
measure: Number of rescue oral steroid courses
timeFrame: 12 months
measure: Quality of life - mini paediatric asthma quality of life questionnaire score
timeFrame: 12 months
measure: Asthma control test score
timeFrame: 12 months
measure: Amount of asthma reliever medication use per week
timeFrame: 12 months
measure: Number of school days absent due to asthma
timeFrame: 12 months
measure: Number of parent/carer work days missed due to their child's asthma
timeFrame: 12 months
measure: Forced expired volume in one second (FEV1)
timeFrame: 12 months
measure: Forced vital capacity (FVC)
timeFrame: 12 months
measure: FEV1:FVC
timeFrame: 12 months
measure: Measurement of fraction of exhaled nitric oxide (FeNO)
timeFrame: 12 months
measure: Acceptability to children and families participating of using an air purifier in their home
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Liverpool
country: United Kingdom
facility: Alder Hey Children's Hospital
state: Merseyside
Study officials:
affiliation: University of Liverpool
name: karl A Holden
role: PRINCIPAL_INVESTIGATOR
References: