louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03521167: Multimodal Analgesia Versus Traditional Opiate Based Analgesia
Official title: Multimodal Analgesia Versus Traditional Opiate Based Analgesia and Cardiac Surgery Outcome
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Cardiac Surgery
Lead sponsor: Shanghai Zhongshan Hospital
Sponsor class: OTHER
First posted: 2018-05-11
Enrollment: 225
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Pain after cardiac surgery can be moderate to severe with incisions to the sternum and lower extremities, and also the placement of chest tubes. Postoperative pain may contribute to delirium, stress, myocardial oxygen demand supply imbalance, etc. Traditionally postoperative pain management after cardiac surgery has been based on opiate analgesics. However, opiates have many deleterious side effects including nausea/vomiting, ileus, bladder dysfunction, and respiratory depression, which substantially influence patient recovery and may delay discharge after surgery.

The current study is designed to evaluate if an opiate sparing multimodal regimen of tylenol, gabapentin, ketamine, lidocaine and dexmedetomidine provided better analgesic effect (pain score, postoperative PCA opioid dose), less side effects (PONV) and improved cardiac surgery outcome (delirium, a-fib, AKI, dysglycemia) compared to a traditional fentanyl and hydromorphine regimen after cardiac surgery. Additionally, it aims to investigate if the benefit of multimodal regimen is achieved by combination of all drugs or all drugs except dexmedetomodine by introducing third group of study patients who will be randomized to all interventions except saline placebo instead of dexmedetomodine infusion.


Eligibility criteria: Inclusion Criteria:

* ASA II-III Grade
* BMI 18-31kg/m2
* Adult patients presenting for on-pump cardiac surgery through median sternotomy

Exclusion Criteria:

* Cardiac surgery without sternotomy
* emergency surgery
* h/o allergy to any of the medications in the research protocol
* hepatic disease with elevated liver enzymes (preoperative SGPT and SGOT elevated to 1.5 times maximum normal value)
* pregnancy
* unable to give consent
* preoperative mental disorders

Primary outcomes:
measure: Evaluation of analgesic effect
timeFrame: Within 3 months after surgery
Secondary outcomes:
measure: Additional opioid consumption
timeFrame: Within 3 days after operation
measure: postoperative delirium
timeFrame: Within 3 days after operation
Other outcomes:
Locations:
Study officials:
affiliation: Fudan University
name: Lin Jin, PHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01557101: Comparison Colon Capsule Endoscopy vs Optical Colonoscopy for Colorectal Cancer Screening in Familiar-Risk Population
Official title: Effectiveness of Colon Capsule Endoscopy as Colorectal Cancer Method of Screening in The Familiar-Risk Population
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Colorectal Cancer, Genetics of
Lead sponsor: Hospital Universitario de Canarias
Sponsor class: OTHER
First posted: 2012-03-19
Enrollment: 200
Sex: ALL
Minimum age (years): 40
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to determine if the adherence to screening in first grade relatives of patients with CCR is higher than optical colonoscopy.

Detailed description: The purpose of this study is to compare the adherence and effectiveness of colon capsule endoscopy (CCE-2) versus conventional colonoscopy to screen first-degree relatives of patients with colorectal cancer.

Eligibility criteria: Inclusion Criteria:

* Asymptomatic first-degree relatives (parents, siblings or children) of CRC patients aged less than 60 years or with two or more first-degree relatives of any age.
* Signing of informed consent.

Exclusion Criteria:

* Personal history of adenoma or CRC.
* History of hereditary CRC.
* Chronic inflammatory disease.
* Presence of digestive symptoms.
* Patients with swallowing problems (dysphagia).
* Personal history of gastrointestinal surgery.
* Enteritis radioactive.
* Renal failure.
* Congestive heart failure
* Allergy or other contraindication to Bysacodyl to PEG or phosphates.
* Pregnancy.
* Suspected bowel obstruction or intestinal strictures or fistulas known.
* Colectomy.
* Paralysis with impaired intestinal motility.
* Any other process that the investigator's discretion to make inadequate participation.

Primary outcomes:
measure: Participation to colorectal cancer screening in first-degree relatives of patients with colorectal cancer
timeFrame: 6 month follow up
Secondary outcomes:
Other outcomes:
Locations:
city: La Laguna
country: Spain
facility: Digestive Service, Huc
state: S/c de Tenerife
city: La Laguna
country: Spain
facility: Hospital Universitario de Canarias
state: S/c de Tenerife
Study officials:
affiliation: Hospital Universitario de Canarias
name: Enrique Quintero, MD. PhD.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Adrian-de-Ganzo Z, Alarcon-Fernandez O, Ramos L, Gimeno-Garcia A, Alonso-Abreu I, Carrillo M, Quintero E. Uptake of Colon Capsule Endoscopy vs Colonoscopy for Screening Relatives of Patients With Colorectal Cancer. Clin Gastroenterol Hepatol. 2015 Dec;13(13):2293-301.e1. doi: 10.1016/j.cgh.2015.06.032. Epub 2015 Jun 29.
Clinical trial NCT00523601: Quetiapine Efficacy in Bipolar Depression Study
Official title: A 8-Week, Multicenter, Open-Label, Observational Study of the Efficacy of Quetiapine Fumarate (SEROQUEL) Immediate-Release Tablets in Adult Patients With Bipolar Depression
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bipolar Depression
Keywords: Bipolar depression
quetiapine
observational
Naturalistic
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2007-08-31
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE

Brief summary: To reassure the clinical study data on Seroquel antidepressant efficacy in patients who are diagnosed as bipolar depression


Eligibility criteria: Inclusion Criteria:

* The patient and the patient's legal representative (if any) must understand the nature of the study and must have given written consent
* Meet DSM-IV-TR criteria for bipolar depression at the time of baseline

Exclusion Criteria:

* Since this programme intends to describe quetiapine use in routine clinical practice when prescribed as treatment of bipolar depression, there are no programme specific exclusion criteria, other than:

Or, any of the following is regarded as a criterion for exclusion from the programme:

1. Serious or unstable, medical illness. Subjects with chronic illness may be included but must be stable and otherwise physically healthy on the basis of a physical examination, medical history
2. Known intolerance for or lack of response to quetiapine, as judged by the investigator

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Kyungki-do
country: Korea, Republic of
facility: Research Site
state: Goyang-si
city: Daejun
country: Korea, Republic of
facility: Research Site
state: Kwangyuk-si
city: Kyungki-do
country: Korea, Republic of
facility: Research Site
state: Suwon-si
Study officials:
affiliation: AstraZeneca Korea
name: Joon-Woo Bahn
role: STUDY_DIRECTOR
References:
Clinical trial NCT02660801: Spinal Manipulation and Spinal Mobilization Effects in Participants With and Without Back Pain
Official title: Spinal Manipulation and Spinal Mobilization Effects in Participants With and Without Back Pain
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Back Pain
Keywords: spinal manipulation
spinal mobilization
spinal stiffness
Lead sponsor: Université du Québec à Trois-Rivières
Sponsor class: OTHER
Collaborators: name: Canadian Institutes of Health Research (CIHR)
name: Fonds de la Recherche en Santé du Québec
name: Unité de recherche en santé musculosqulettique
First posted: 2016-01-21
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The objective of the present study is to compare the neuromechanical responses to spinal manipulation and spinal mobilization in participants with chronic nonspecific middle back pain.

Detailed description: Although evidences suggest a similar effectiveness of spinal manipulation and spinal mobilization, there is no study that compares the neuromechanical effects of these manual therapies in a experimental context and with the standardization of both interventions. Therefore, the objective of the present study is to compare the neuromechanical responses to spinal manipulation (low-amplitude and high-velocity dynamic thrust) and spinal mobilization (repetitions of a low-amplitude and low-velocity nonthrust movement) in participants with and without chronic nonspecific back pain.

Eligibility criteria: Inclusion Criteria:

* presenting or not a history of chronic nonspecific back pain

Exclusion Criteria:

* History of back trauma or surgery
* Severe osteoarthritis
* Inflammatory arthritis
* Vascular conditions
* Contraindication to the use of spinal manipulation or spinal mobilization
* Pregnancy
* Scoliosis

Primary outcomes:
measure: Global Spinal Stiffness
timeFrame: two-minutes before spinal manipulation delivery up to two-minutes after
measure: Terminal Spinal Stiffness
timeFrame: two-minutes before spinal mobilization delivery up to two-minutes after
measure: Pressure Provoked Pain
timeFrame: immediately after the therapeutic modality application
measure: Muscular Response, Superior Level Ratio
timeFrame: During the spinal manipulation and mobilization
measure: Muscular Response, Inferior Level Ratio, Normalized RMS
timeFrame: During the spinal manipulation and mobilization
Secondary outcomes:
Other outcomes:
Locations:
city: Trois-Rivieres
country: Canada
facility: Université du Québec à Trois-Rivières
state: Quebec
Study officials:
affiliation: Université du Québec à Trois-Rivières
name: Martin Descarreaux, DC, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00631501: Doxycycline for Lateral Epicondylalgia - RCT
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Lateral Epicondylalgia (Tennis Elbow)
Keywords: tendinopathy
tennis elbow
lateral epicondylitis
lateral epicondylalgia
MMP-inhibitor
Lead sponsor: Kaunas University of Medicine
Sponsor class: OTHER
Collaborators: name: University Hospital, Linkoeping
First posted: 2008-03-07
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Matrix metalloproteinases are involved in the pathogenesis of tendinopathy. Doxycycline, a widely available pharmaceutical agent mostly used for its antibiotic properties, also functions as an inhibitor of MMPs.

This study aims to investigate the effect of doxycycline treatment on lateral epicondylalgia (tennis elbow). During three weeks, patients receive doxycycline tablets 100 mg twice daily, or placebo. Main outcome variable is pain (VAS) at three weeks.

Serum and/or plasma levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases are measured.


Eligibility criteria: Inclusion Criteria:

* Age 18-65
* Pain at the lateral side of the elbow ≥8 weeks
* Local tenderness on palpation of the lateral epicondyle
* Pain on resisted extension of the wrist

Exclusion Criteria:

* Rheumatic disorder
* History of fibromyalgia or generalised pain
* Elbow surgery (on the painful side)
* Active infection
* Glucocorticoid treatment during the duration of symtoms of epicondylalgia
* NSAID use within 1 w before presentation and during the study
* Pregnancy
* Taking drug that might interact with doxycycline

Primary outcomes:
measure: Pain (VAS)
Secondary outcomes:
Other outcomes:
Locations:
city: Kaunas
country: Lithuania
facility: Dept of Orthopaedics, Kaunas Medical University
Study officials:
References:
Clinical trial NCT05786001: Multimodal Noninvasive Assessment of Peripheral Circulation in Chronic Limb-threatening Ischemia
Official title: Evaluation of Lower Limb Angiosome Perfusion and Oxygenation Using Thermal and Hyperspectral Imaging
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Chronic Limb Threatening Ischemia
Keywords: hyperspectral imaging
thermal imaging
angiosomes
CLTI
diabetes
Lead sponsor: Tampere University
Sponsor class: OTHER
Collaborators: name: Tampere University Hospital
First posted: 2023-03-27
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: * patients at the Vascular Centre Polyclinic and Vascular Surgery Ward at Tampere University Hospital
* Orthopaedic patients, joint replacement hospital and orthopaedic ward at Tampere University Hospital
* students and staff from Tampere University and Tampere University Hospital

Brief summary: Assessment of a novel diagnostic method for screening and diagnosing chronic limb-threatening ischemia (CLTI). Using hyperspectral and thermal imaging, the perfusion and oxygenation in the lower limbs will be studied in healthy and unhealthy individuals.


Eligibility criteria: Inclusion Criteria:

* for CLTI patients age \>50
* for age control group age \>50 and not diagnosed with cardiovascular diseases. 0.9 \< ABI \< 1.3
* for healthy group 18 \<= age \<= 50 and no history of cardiovascular disease
* volunteering for study

Exclusion Criteria:

* inability to give informed consent
* denial

Primary outcomes:
measure: Perfusion in lower limb angiosomes assessed by thermal imaging
timeFrame: 45 minutes during the procedure starting from the first measurement and ending after the last measurement
measure: Oxygenation in lower limb angiosomes assessed by hyperspectral imaging.
timeFrame: 45 minutes during the procedure starting from the first measurement and ending after the last measurement
Secondary outcomes:
Other outcomes:
Locations:
city: Tampere
country: Finland
facility: Tampere University
state: Pirkanmaa
Study officials:
affiliation: Tampere University, Tampere University Hospital
name: Niku Oksala, MD, PhD, DSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05117801: Evaluation of Pétale® (Small Hearing Test Equipment for Children) for the Screening of Hearing Disorders in Children From 9 Months to 3 Years Old by the General Practitioner or Pediatrician
Official title: Evaluation of Pétale® (Small Hearing Test Equipment for Children) for the Screening of Hearing Disorders in Children From 9 Months to 3 Years Old by the General Practitioner or Pediatrician
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Petale
Hearing Disorders
Child Development
Lead sponsor: Ramsay Générale de Santé
Sponsor class: OTHER
Collaborators: name: European Clinical Trial Experts Network
First posted: 2021-11-11
Enrollment: 300
Sex: ALL
Minimum age (years): 9
Maximum age (years): 3
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The aim of this study is to confirm the value of this new version of Pétale® ((small equipment for testing the child's hearing) in the daily practice of general practitioners or pediatricians for the screening of hearing disorders in very young children.

Detailed description: The research procedure is auditory stimulation using Pétale® (small equipment for testing the child's hearing) based on the "orientation reflex" ("Ewing" test): the child is seated on the companion's knees between the two enclosures and the investigator observes whether or not he is attracted to a familiar calibrated noise coming from one side or the other.

Eligibility criteria: Inclusion Criteria:

* Chil, girl or boy between 9 months and 3 years-old
* Child seen in consultation by a general practitioner or a pediatrician whatever the reason for consultation
* Child attached to a beneficiary of a social security scheme
* Signature of informed consent by parents.

Exclusion Criteria:

* Age greater than 3 years and less than 9 months
* Refusal of one or more parents during the consultation
* State of the child which does not allow the screening test to be carried out

Primary outcomes:
measure: Sensitivity
timeFrame: 2 weeks
measure: Specificity
timeFrame: 2 weeks
measure: Positive Predictive Value (PPV):
timeFrame: 2 weeks
measure: Negative Predictive Value (NPV)
timeFrame: 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Lambres-lez-Douai
country: France
facility: Clinique Saint-Amé
Study officials:
References:
Clinical trial NCT05176301: Cervical Cord to Canal Diameter Ratio
Official title: Comparison Between the Coronal Diameters of the Cervical Spinal Canal and Spinal Cord Measured Using Computed Tomography and Magnetic Resonance Imaging in Korean Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cervical Pain
Keywords: Coronal
Cervical canal diameter
Cervical cord diameter
Lead sponsor: Daegu Catholic University Medical Center
Sponsor class: OTHER
First posted: 2022-01-04
Enrollment: 100
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients who visited Daegu catholic university hospital

Brief summary: Cervical epidural block could cause spinal cord injury if the epidural needle is over-inserted and punctures the spinal cord. Investigators retrospectively evaluated the imaging data of 100 patients (50 men and 50 women) who underwent both cervical computed tomography (CT) and cervical magnetic resonance imaging (MRI) at our hospital. Investigators measured the diameters of the spinal canal and spinal cord from the 3rd cervical vertebra to the 1st thoracic vertebra (T1) at each level by using the patients' cervical CT and MR images. The spinal cord and spinal canal diameters were measured in the transverse plane of cervical MR and CT images, respectively.

Detailed description: The spinal canal diameter, i.e., the epidural transverse diameter, was measured as the distance between the innermost border of the left and right pedicles at each upper pedicular level from C3 to T1 on transverse CT images by using a picture archiving and communication system (PACS; INFINITT PACS G3, INFINITT Healthcare, Korea) The spinal cord diameter was measured between the left and right outermost distances of the cord at each upper pedicular level, which were almost the same locations used for measuring the spinal canal diameter, from C3 to T1 on transverse MR images by using the PACS.

Eligibility criteria: Inclusion Criteria:

* 100 patients (50 men and 50 women aged 20 to 70 years old) who visited our hospital and underwent both cervical CT and MRI simultaneously

Exclusion Criteria:

* patients who had a history of cervical spine surgery or cervical cord edema, whose CT or MR images did not include all the cervical vertebrae from C3 to T1,
* patients who had at least one missing medical detail such as diagnosis, age, height, or weight.

Primary outcomes:
measure: the cord to canal diameter ratio
timeFrame: from December 1, 2020 through study completion, an average of 2 years were investigated retrospectively.
Secondary outcomes:
Other outcomes:
Locations:
city: Daegu
country: Korea, Republic of
facility: Daegu Catholic University Hospital
Study officials:
affiliation: Daegu Catholic University Medical Center
name: Jin Y Jung, M.D.
role: STUDY_CHAIR
References:
Clinical trial NCT06763601: Effect of Shoulder Symptom Modification Procedure (SSMP) in Managing Patients with Frozen Shoulder
Official title: Effect of Shoulder Symptom Modification Procedure (SSMP) in Managing Patients with Frozen Shoulder: a Pilot Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Frozen Shoulder
Keywords: SSMP
MWM
sham mobilization
frozen shoulder
Lead sponsor: Gulf Medical University
Sponsor class: OTHER
First posted: 2025-01-08
Enrollment: 36
Sex: ALL
Minimum age (years): 40
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: each participant will be randomly allocated one group. there are three groups in total
Primary purpose: TREATMENT

Brief summary: the study is about intervention to patient with frozen shoulder to help patients improve function and shoulder disability , reduce pain and improve range of motion, the main aim of this study is to find out which treatment intervention SSMP , MWM and sham mobilization give effective results


Eligibility criteria: Inclusion Criteria:

* • Diagnosis of adhesive capsulitis confirmed by a healthcare professional.

  * Scores more than 2 in adhesive capsulitis scale
  * Range of motion affected in capsular pattern
  * Age between 40-65 years.
  * Willingness to participate by signing informed consent

Exclusion Criteria:

* Having any history of shoulder dislocation
* Humerus fractures or trauma
* Diagnosed with any sort of cancer
* History of cardiovascular disease

Primary outcomes:
measure: Shoulder Pain And Disability Index
timeFrame: from enrollment to week 4,6,8
measure: Numeric Pain Rating Scale
timeFrame: from enrollment to 8 weeks
Secondary outcomes:
measure: Range Of Motion
timeFrame: week 4,6,8
measure: Patients' Global Impression of Change (PGIC) scale
timeFrame: at enrollment and on 8th week
Other outcomes:
Locations:
city: Ajman
country: United Arab Emirates
facility: Thumbay Physical Therapy and Rehabilitation Hospital
Study officials:
References: