Clinical trial NCT04791657: Outcome of Elderly Patients With Appendicitis
Official title: Factors Associated With Postoperative Complications After the Surgical Treatment of Appendicitis in Elderly Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Appendicitis Acute
Keywords: appendicitis
geriatrics
Lead sponsor: Gulhane Training and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2021-03-10
Enrollment: 80
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients aged 65 years and older undergoing appendectomy for acute appendicitis are included in this study

Brief summary: This study aims to evaluate factors that predict 30-day complications after the surgical treatment of appendicitis in elderly patients.

Detailed description: Appendicitis in elderly patients is more challenging due to delayed presentation and higher comorbidities, which is associated with increased postoperative morbidity and mortality. In this study, we aim to investigate the factors that predict 30-day complications after the surgical treatment of appendicitis in elderly patients. Records of patients who underwent appendectomy for appendicitis will be extracted. The primary outcome is 30-day postoperative complications. Independent variables examined include demographics, comorbidities, preoperative laboratory values, pathological findings, and surgical features. Both univariate and multivariate regression will be performed to identify factors associated with postoperative complications.

Eligibility criteria: Inclusion Criteria:

* Patients aged 65 years and older
* Patients undergoing appendectomy for acute appendicitis (pathologically confirmed)
* Patients having complete records of clinical data and postoperative follow-up records

Exclusion Criteria:

* Patients younger than 65 years
* Patients undergoing an appendectomy as part of another major operation or those with appendiceal malignancy
* Patients who are treated nonoperatively for acute appendicitis

Primary outcomes:
measure: 30-day postoperative complication rate
timeFrame: 30 days
Secondary outcomes:
measure: In-hospital mortality rate
timeFrame: 30 days
measure: 30-day readmission rate
timeFrame: 30 days
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gulhane Training and Research Hospital
Study officials:
affiliation: Gulhane Training and Research Hospital
name: Suleyman U Celik, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Angeramo CA, Dreifuss NH, Giacone J, Schlottmann F. Outcomes of Acute Appendicitis in Elderly Patients: a Single Center Analysis of 2000 Laparoscopic Appendectomies. J Gastrointest Surg. 2020 Dec;24(12):2859-2861. doi: 10.1007/s11605-020-04726-z. Epub 2020 Aug 31. No abstract available.
citation: Yang J, Yu K, Li W, Si X, Zhang J, Wu W, Cao Y. Laparoscopic Appendectomy for Complicated Acute Appendicitis in the Elderly: A Single-center Experience. Surg Laparosc Endosc Percutan Tech. 2017 Oct;27(5):366-368. doi: 10.1097/SLE.0000000000000447.
citation: Hui TT, Major KM, Avital I, Hiatt JR, Margulies DR. Outcome of elderly patients with appendicitis: effect of computed tomography and laparoscopy. Arch Surg. 2002 Sep;137(9):995-8; discussion 999-1000. doi: 10.1001/archsurg.137.9.995.
citation: Pokharel N, Sapkota P, Kc B, Rimal S, Thapa S, Shakya R. Acute appendicitis in elderly patients: a challenge for surgeons. Nepal Med Coll J. 2011 Dec;13(4):285-8.