Clinical trial NCT03013725: The Hordaland Health Study
Official title: The Hordaland Health Studies (HHS)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Disease
Lead sponsor: University of Bergen
Sponsor class: OTHER
Collaborators: name: Part of CONOR, and participates in the Norwegian Epidemiologic Osteoporosis Studies
First posted: 2017-01-06
Enrollment: 36000
Sex: ALL
Minimum age (years): 40
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Approximately 36,000 residents of Hordaland county participated in the studies (both men and women), ca. 18,000 in 1992-93 and ca. 26,000 in 1997-99. About 7,000 of those who participated in the 1992-93 survey also participated in 1997-99.

Brief summary: The Hordaland Health Studies (HHS) were conducted in 1992-93 (The Homocysteine study) and in 1997-99 (HUSK). Both surveys were conducted as a joint project between the University of Bergen, the Norwegian Health Screening Service (SHUS) (now part of the National Institute of Public Health) and the Municipal Health Service in Hordaland.

The main focus of the studies is on chronic diseases including cardiovascular disease, cancer, osteoporosis, anxiety and depression. Some projects focus on psychosocial factors, occupational research, musculoskeletal diseases, urinary incontinence and mapping of drug use. The main purpose of the surveys is to gather information so that disease ultimately can be prevented.

Approximately 36,000 residents of Hordaland county participated in the studies, ca. 18,000 in 1992-93 and ca. 26,000 in 1997-99. About 7,000 of those who participated in the 1992-93 survey also participated in 1997-99.


Eligibility criteria: Inclusion Criteria:

* Born in a specific time-period
* From Hordaland County
* Community-dwelling people who were able to come to the study site on their own, and able to fill out questionnaires.

Exclusion Criteria:

* Not born within the specific time-period
* Not from Hordaland County
* Institutionalized People
* People who were not able to fill out questionnaires

Primary outcomes:
measure: Total mortality.
timeFrame: Participants are followed from baseline (1992-93 or 1997-99) until death or December 31st, 2015.
Secondary outcomes:
measure: Mortality or morbidity from chronic diseases (for example cardiovascular disease, cancer). Also, award of disability pension are used as an outcome.
timeFrame: Participants are followed from baseline (1992-93 or 1997-99) until time of diagnosis/death from disease or the last day of follow-up.
Other outcomes:
Locations:
Study officials:
References:
citation: Haugsgjerd TR, Egeland GM, Nygard OK, Vinknes KJ, Sulo G, Lysne V, Igland J, Tell GS. Association of dietary vitamin K and risk of coronary heart disease in middle-age adults: the Hordaland Health Study Cohort. BMJ Open. 2020 May 21;10(5):e035953. doi: 10.1136/bmjopen-2019-035953.
citation: Zuo H, Tell GS, Ueland PM, Nygard O, Vollset SE, Midttun O, Meyer K, Ulvik A. The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK). Am J Clin Nutr. 2018 Jan 1;107(1):105-112. doi: 10.1093/ajcn/nqx012.