louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05097638: Lung Health After Tuberculosis: Clinical and Functional Assessment in Post Pulmonary Tuberculosis Egyptian Patients.
Official title: Lung Health After Tuberculosis: Clinical and Functional Assessment in Post Pulmonary Tuberculosis Egyptian Patients.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pulmonary Tuberculoses
Pulmonary Function; Newborn, Abnormal
Keywords: pulmonary Tuberculosis
Spirometry
Pulmonary Function
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2021-10-28
Enrollment: 210
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient more than 18 years old had been newly diagnosed drug-sensitive first episode pulmonary tuberculosis, confirmed by sputum smear microscopy were included in the study. He completed an outpatient course of standard first line anti-tuberculosis therapy (6 months) and declared as cured without radiological change over the past year (in comparable with chest X-ray at the end of TB treatment).

Brief summary: Some of pulmonary tuberculous patients who completed their medication course experience lung function impairment

Detailed description: Some of pulmonary tuberculous patients who completed their medication course experience lung function impairment which may influence their quality of life. However, the pattern and nature of post-tuberculosis lung impairment is still not identified. Thus, the aim of this study was to determine the type and degree of lung physiology changes in previously treated tuberculous patients which latter may affect their quality of life; thus helping clinicians for early diagnosis of lung impairment, especially in tuberculous endemic areas.

Eligibility criteria: Inclusion Criteria:

* Patient completed an outpatient course of standard first line anti-tuberculosis therapy and declared as cured

Exclusion Criteria:

* Smoker (to avoid spirometry biases).
* Extrapulmonary tuberculosis cases
* Multidrug resistant tuberculosis
* known contraindications to spirometry testing
* Individuals with chest wall deformities or neuromuscular diseases
* Patients who failed to achieve acceptability and reproducibility criteria of the spirometry test
* Defaulter cases or irregular treatment,
* known coexisting chronic lung disease as history of asthma or interstitial lung diseases
* A history of illicit drug use
* Patients with comorbidities: renal and hepatic insufficiency, heart diseases and metabolic disorders.

Primary outcomes:
measure: Post tuberculosis lung functional impairment
timeFrame: 6 months
measure: post tuberculosis persistent clinical symptoms
timeFrame: 6 months
measure: Grading of obstruction function:
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Assuit
country: Egypt
facility: Chest Department-faculty of medicine-Assuit university
Study officials:
References:
Clinical trial NCT04759638: Short Running Head Obesity in Rectal Cancer Patients
Official title: Body Mass Index Role in the Oncological Outcome of Locally Advanced Rectal Cancer: The Two BMI Extremes as Comparative Groups, A Retrospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rectal Cancer
Keywords: Oncology
Colorectal Cancer
Surgery
Surgical Oncology
Obesity
Lead sponsor: King Hussein Cancer Center
Sponsor class: OTHER
First posted: 2021-02-18
Enrollment: 294
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 294 patients included in the study

Brief summary: There is a controversy regarding the effect of the two Body Mass Index (BMI) extremes on the oncological outcome of rectal cancer.

The obesity paradox appears to exist in rectal cancer patients treated with nCRT and surgery, as it was associated with significantly higher rates of pathological complete response and R0 resection.

Underweight patients were at higher risk for anastomotic leak and R1 resection.

Detailed description: Background:

Obesity and underweight are associated with increased risk of postoperative morbidity in colorectal cancer patients undergoing surgery. There is a controversy regarding the effect of the two Body Mass Index (BMI) extremes on the oncological outcome of rectal cancer.

Objective:

The aim of this study was to evaluate the effect of BMI on short- and long-term oncological outcomes as well as postoperative complications in rectal cancer patients who received neoadjuvant chemoradiotherapy (nCRT) followed by surgery.

Setting:

Tertiary Cancer Center serving pediatric and adult patients in Jordan and the Middle East.

Patients:

The medical records of patients with stage II-III rectal cancer who received nCRT followed by surgery during 2006 to 2018 were retrospectively reviewed. The patients were subdivided according to their BMI into less than 20 kg/m2 defined as underweight; between 20 to 30 kg/m2 defined as normal range weight, above 30 kg/m2 defined as obese.

Main Outcome Measures:

Disease-Free Survival (DFS), Overall Survival, Pathological Complete Response (CR)

Eligibility criteria: Inclusion Criteria:

* Patients who underwent rectal surgery at King Hussein Cancer Center (KHCC) from 2006 to 2018 were identified. Those with locally advanced rectal cancer (stages II and III) who underwent nCRT followed by surgery with curative intent were included.

Exclusion Criteria:

* Patients with early rectal cancer (stage I) who did not require nCRT and those who underwent rectal surgery as part of a staged or simultaneous approach for metastatic disease (stage IV) were excluded.

Primary outcomes:
measure: Disease-Free Survival (DFS)
timeFrame: 5 yers
measure: Overall Survival (OS)
timeFrame: 5 years
Secondary outcomes:
measure: Pathological Complete Response (CR)
timeFrame: 5 years
Other outcomes:
Locations:
city: Amman
country: Jordan
facility: King Hussein Cancer Center
Study officials:
References:
Clinical trial NCT00363038: Effects of Topical Vitamin K, Vitamin K and Retinol, and Arnica on Post-Laser Bruising
Official title: Effects of Topical Vitamin K, Vitamin K and Retinol, and Arnica on Post-Laser Bruising
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ecchymosis
Keywords: Bruising
Topical 20% arnica
Lead sponsor: Northwestern University
Sponsor class: OTHER
First posted: 2006-08-15
Enrollment: 16
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The objective of this study is to assess the comparative utility of topical formulations in hastening the resolution of skin bruising. For each subject, four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser. Randomization was used to assign one topical agent (5% vitamin K, 1% vitamin K and 0.3% retinol, 20% arnica or white petrolatum) to exactly one bruise per subject, which was then treated under occlusion twice a day for 2 weeks. A dermatologist rated bruises in standardized photographs immediately after bruise creation and at week 2.


Eligibility criteria: Inclusion Criteria:

* Age 20-60
* Subjects are in good health.
* Subjects have willingness and the ability to understand and provide informed consent for participation in the study.

Exclusion Criteria:

* Subjects who are currently using any anticoagulation therapy (Warfarin, Heparin, Aspirin)
* Subjects who have a history of bleeding disorders.
* Subjects who are unable to understand the protocol or to give informed consent
* Subjects with mental illness
* Subjects who are pregnant or nursing.
* Subjects who have active systemic or local infection
* Subjects with systemic or local skin disease.
* Subjects with systemic illness.

Primary outcomes:
measure: Average Bruise Change
timeFrame: Baseline and 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Northwestern University Feinberg School of Medicine, Department of Dermatology
state: Illinois
Study officials:
affiliation: Northwestern University
name: Murad Alam, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Leu S, Havey J, White LE, Martin N, Yoo SS, Rademaker AW, Alam M. Accelerated resolution of laser-induced bruising with topical 20% arnica: a rater-blinded randomized controlled trial. Br J Dermatol. 2010 Sep;163(3):557-63. doi: 10.1111/j.1365-2133.2010.09813.x.
Clinical trial NCT04122638: Prevalence of Sarcopenia and Sarcopenic Obesity in Older Adults
Official title: Prevalence of Sarcopenia and Sarcopenic Obesity in Community-dwelling Outpatient Older Adults
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sarcopenia
Sarcopenic Obesity
Osteopenia, Osteoporosis
Keywords: Older adults
Lead sponsor: Goztepe Training and Research Hospital
Sponsor class: OTHER
Collaborators: name: Istanbul Medeniyet University
name: Istanbul University
First posted: 2019-10-10
Enrollment: 572
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Community-dwelling older adults

Brief summary: Syndromes such as sarcopenia, sarcopenic obesity and osteosarcopenic obesity are commonly seen in older adults. They result from the impairment of muscle, bone and adipose tissue. Thus, they lead to a decrease in quality of life and increase morbidity and mortality. The aim of this study is to report the prevalence of sarcopenia, sarcopenic obesity and osteosarcopenic obesity in community-dwelling outpatient older adults and to investigate the related factors.


Eligibility criteria: Inclusion Criteria:

* Being at the age of 65 or older
* Being able to complete 4-m walk test

Exclusion Criteria:

* \<24 points on Mini-Mental State Examination
* 12 points or higher on Geriatric Depression Scale

Primary outcomes:
measure: Handgrip Strength
timeFrame: 10 minutes
measure: Muscle mass
timeFrame: 5 minutes
measure: Bone density
timeFrame: 30 minutes
measure: Percentage of body fat
timeFrame: 5 minutes
Secondary outcomes:
measure: Gait speed
timeFrame: 3 minutes
measure: Physical Activity
timeFrame: 5-10 minutes
measure: Nutritional Status
timeFrame: 10 minutes
measure: Activities of Daily Living
timeFrame: 10 minutes
measure: Instrumental Activities of Daily Living
timeFrame: 10 minutes
measure: Depression
timeFrame: 10 minutes
measure: Mini-Mental State Examination
timeFrame: 10-15 minutes
measure: Blood Sample Analysis
timeFrame: 5 minutes
measure: Comorbidities
timeFrame: 5 minutes
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Goztepe Training and Research Hospital
Study officials:
References:
citation: Demirdag F, Kolbasi EN, Aykut GB, Guler KY, Murat S, Ozturk GB, Oguz A. Nutritional status as a mediator between the age-related muscle loss and frailty in community-dwelling older adults. Arch Gerontol Geriatr. 2022 Jan-Feb;98:104569. doi: 10.1016/j.archger.2021.104569. Epub 2021 Nov 3.
Clinical trial NCT03601338: Low Molecular Weight Heparin in Pregnancies With Unexplained Stillbirths
Official title: Second Generation Low Molecular Weight Heparin (Bemiparin) as a Prophylactic for Management of Subsequent Pregnancy After an Unexplained Stillbirth: A Clinical Comparative Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Unexplained Stillbirth
Keywords: Unexplained stillbirth
Low molecular Weight Heparin
Umbilical artery
Doppler Ultrasound
Antenatal care
Lead sponsor: Hawler Medical University
Sponsor class: OTHER
First posted: 2018-07-26
Enrollment: 140
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 44
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: pregnant women with history of unexplained fetal death
Primary purpose: PREVENTION

Brief summary: Bemiparin for pregnant women with abnormal umbilical artery Doppler ultrasound

Detailed description: 152 women with history of unexplained stillbirths were identified , umbilical arty Doppler ultrasound was conducted for them at 20-22 weeks gestation . they were divided into two group , group one are those with abnormal resistant index (= or more than 0.6) thy received Bemiparin 2500 IU subcutaneously daily up to 24 hours before delivery .

Group 2 with normal umbilical artery resistant index received no any interventions just routine antenatal follow up .

Eligibility criteria: Inclusion Criteria:

* Second pregnancy after previous unexplained fetal death
* Singleton pregnancy
* No any medical disorders during pregnancy like diabetes or Systemic Lupus Erythematosus
* Normally located placenta
* No congenital fetal anomalies
* Patient accept to participate

Exclusion Criteria:

* Confirmed thrombophilia
* Twin pregnancies
* Refused to participate

Primary outcomes:
measure: Stillbirth
timeFrame: after 20 weeks gestation to the delivery of fetus
measure: Early neonatal death
timeFrame: First week of life
measure: Low birth weight
timeFrame: first hour of life
Secondary outcomes:
measure: Preterm labor
timeFrame: 20-37 weeks
measure: Pre-eclampsia
timeFrame: 20-41 week gestation
measure: major abruptio placenta
timeFrame: 20-41 week gestation
Other outcomes:
Locations:
city: Erbil
country: Iraq
facility: Hawler Medical University
state: Kurdistan Region
Study officials:
affiliation: Hawler Medical University, college of Medicine, department of Obstetrics and Gynecology
name: shahla k. Alalaf, M.D
role: PRINCIPAL_INVESTIGATOR
affiliation: Kurdistan Board for Medical Specialist
name: Ariana K. Jawad, CABOG
role: STUDY_DIRECTOR
affiliation: Maternity Teaching Hospital
name: Mahabad S. Ali, Diploma
role: STUDY_CHAIR
References:
Clinical trial NCT04211038: Assessment of Neural Inspiratory Time Through sEMG and EMGdi
Official title: Assessment of Neural Inspiratory Time Through Transesophageal and Surface Electromyography
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Copd
Ventilation
Rehabilitation
Lead sponsor: Guangzhou Medical University
Sponsor class: OTHER
Collaborators: name: Guangzhou Medical University
First posted: 2019-12-26
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The onset and offset of the neural inspiratory time are fundamentally important measurements in studies of patientventilator interaction, where the level of assistance delivered by the ventilator is controlled by the patient's demand. The onset of neural inspiratory time can be determined in esophageal pressure, transdiaphragmatic pressure, and EMG signals. The investigator compare the onset measured by EMG, esophageal and transdiaphragmatic pressure, and consider that the correlation between them is well in different conditions.

Detailed description: The onset and offset of the neural inspiratory time are fundamentally important measurements in studies of patien-tventilator interaction, where the level of assistance delivered by the ventilator is controlled by the patient's demand. Patient-ventilator asynchrony evaluated using the time lag between onset of the neural inspiratory time and the onset of a mechanical ventilation signal. The onset of neural inspiratory time can be determined in esophageal pressure, transdiaphragmatic pressure, and EMG signals. The investigator compare the onset measured by EMG, esophageal and transdiaphragmatic pressure, and consider that the correlation between them is well in three different conditions.

Eligibility criteria: Inclusion Criteria:

* normal cardio-pulmonary function
* without low inspiratory muscle strength
* non-smoker
* without history of the nervous system and respiratory system disease
* sever to very severe stable stage

Exclusion Criteria:

* systemic application of corticosteroids nearly 4 weeks

Primary outcomes:
measure: the onset and duration of neural inspiratory time
timeFrame: through study completion, an average of 5 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Guangzhou Medical University.
state: Guangdong
Study officials:
References:
Clinical trial NCT01135238: Adrenalectomy for Solitary Adrenal Gland Metastases
Official title: The Use of Adrenalectomy in Patients With Solitary Adrenal Gland Metastases
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Adrenal Gland Metastases
Adrenalectomy
Keywords: adrenalectomy
metastasis
morbidity
mortality
survival
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2010-06-02
Enrollment: 168
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing adrenalectomy for metastatic disease.

Brief summary: The adrenal glands are one of the most common organs involved in metastatic disease. Metastases are the second most common type of adrenal mass, second only to adenomas. It is a frequent finding during autopsy with a reported rate as high as 27% in patients with known primary malignancy. Although several studies have found an increased survival in patients who undergo resection of solitary adrenal metastases the indications for adrenalectomy in cases of metastatic adrenal tumor remain controversial. Collinson et al reported an increased survival in patients with melanoma. Median survival was 16 months for patients who underwent adrenalectomy compared to 5 months for patients with documented adrenal metastases treated non surgically.

The aim of this study is to compare retrospectively in case and control study, performing adrenalectomy, open or laparoscopic, versus supportive treatment for patients with solitary adrenal gland metastases. The investigators will review charts of patients between January 1994 and November 2009 who had adrenal gland metastases. The variables the inevstigators will compare are mortality, morbidity, primary tumour sites, histological cell type, age, tumour size, presence of synchronous metastases, mean time from diagnosis of primary tumor to treatment of adrenal metastases, indication for adrenalectomy, partial versus total adrenalectomy, suspected versus confirmed metastatic disease.


Eligibility criteria: Inclusion Criteria:

* Metastatic disease to the adrenal gland

Exclusion Criteria:

* Primary adrenal neoplasm

Primary outcomes:
measure: Adrenalectomy improves overall survival in patients with solitary metastasis
timeFrame: 25 years
Secondary outcomes:
measure: Adrenalectomy can be performed with minimal morbidity in patients with metastatic lesions to the adrenal gland.
timeFrame: 25 years
Other outcomes:
Locations:
Study officials:
affiliation: Mayo Clinic
name: Melanie L Richards, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01256138: Allogene MSCs Transplantation in Liver for Patients With Chronic Liver Diseases Through Portal Vein by Ultrasound Guiding
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Allogene Transplantation
Chronic Liver Diseases Patients
Through Portal Vein by Ultrasound Guiding
Keywords: Allogene MSCs
transplantation
chronic liver diseases
portal vein
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2010-12-08
Enrollment: 60
Sex: ALL
Minimum age (years): 15
Maximum age (years): 65
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with chronic liver diseases including: viral hepatitis, alcoholic liver disease, autoimmune liver disease and so on.

Brief summary: Allogene MSCs transplantation will be performed in patients with chronic liver diseases through portal vein by ultrasound guiding and therapeutic effects including short-term effects and long-term follow-up will be compared and investigated.


Eligibility criteria: Inclusion Criteria:

1. chronic liver diseases including: viral hepatitis, alcoholic liver disease, autoimmune liver disease.
2. age: 15-65 years old.

Exclusion Criteria:

1. pregnant women and women in lactation.
2. other systems and organs disfunction
3. space-occupying lesion were found in liver.
4. concurrent infection with HIV and other immunodeficiency diseases.
5. DIC and active bleeding were confirmed.

Primary outcomes:
measure: Short-term therapeutic effects at 1-8 weeks after Allogene MSCs transplantation
timeFrame: 1-8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Department of Infectious Diseases, 3rd Affiliated Hospital of Sun Yat-sen University
state: Guangdong
Study officials:
References:
Clinical trial NCT06636279: A Randomized Study of Gas Bubble Technique in Cataract Surgery
Official title: Clinical Effects of "Gas Bubble Technique" on Corneal Endothelial Recovery After Cataract Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Corneal Edema After Cataract Surgery
Lead sponsor: Sichuan Provincial People's Hospital
Sponsor class: OTHER
First posted: 2024-10-10
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To investigate the efficiency and safety of using "Gas Bubble Technique" to reduce corneal endothelial damage in hard nucleus cataract patients.

Detailed description: The study is designed to: Test the hypothesis that the "Gas Bubble Technique" is an effective method for reducing corneal endothelial damage. Describe and evaluate the effects of "Gas Bubble Technique" on a well-defined group of patients over a 1-month period following treatment.

Eligibility criteria: Inclusion Criteria:

* Sign the informed consent approved by the Ethics Committee
* Over 18 years of age
* Catract patients with hard nucleus (LOSIII N Score ≥4) who are scheduled for phacoemulsification
* Feasible for all visits and willing to follow instructions from the study investigator

Exclusion Criteria:

* Any ocular surgery history
* Currently diagnosis of severe ocular disease and under medication
* Uncontrolled systemic diseases

Primary outcomes:
measure: central corneal thickness (CCT)
timeFrame: 1 week and 1 month
measure: endothelial cell count (ECC)
timeFrame: 1 week and 1 month
measure: coefficient of variation (CV)
timeFrame: 1 week and 1 month
measure: hexagonality (HEX)
timeFrame: 1 week and 1 month
Secondary outcomes:
measure: Intraocular pressure
timeFrame: 1day, 1 week and 1 month
Other outcomes:
Locations:
city: Chengdu
country: China
facility: Sichuan Provincial People's Hospital
state: Sichuan
Study officials:
References: