Clinical trial NCT03356301: Study of the Aorta Adaptations to Exercise in Triathletes During Sports Season (CoATri)
Official title: Study of the Remodeling of the Ascending Aorta During the Sports Season in Long Distance Triathletes Versus Controls
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stiffness, Aortic
Cardiac Remodeling, Ventricular
Vascular Remodeling
Magnetic Resonance Imaging, Functional
Athletes
Keywords: Aortic compliance
Aortic distensibility
CMR
Triathletes
Ventriculo-atrial coupling
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2017-11-29
Enrollment: 63
Sex: MALE
Minimum age (years): 18
Maximum age (years): 39
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Regular sustained physical activity creates a cardiac remodelling : it is athlete's heart. In our preliminary work published in 2016, the investigators demonstrated in a small population of triathletes that there is also a vascular remodelling named athlete's artery. Moreover, the investigators know that left ventricle and aorta behave together like a couple. So they want to study by Cardiovascular Magnetic Resonance Imaging the impact of triathlon on the cardiac AND aortic remodelling.


Eligibility criteria: Inclusion Criteria:

* to be enrolled in a social security plan.
* to have a BMI between 18,5 and 25 kg/m²
* to have received full information on the organization of the research and having signed its informed consent
* to have carried out a clinical screening adapted to the research

  \*\*\* Triathlete group:
* to have a minimum performance level: between 2h and 2h45 on an M triathlon during the past year (provide proof),
* to participate in 2018 in a long distance triathlon, i. e. at least distance L
* to have a defined training volume: less than 8 hours per week during the winter months and between 10 and 15 hours per week in preparation of the objective

  \*\*\*Control group:
* to have no more than 150 minutes of moderate physical activity per week (footing, brisk walking, cycling, etc.).

Exclusion Criteria:

* Persons referred to in Articles L. 1121-5 to L. 1121-8 and L1122-2 of the Public Health Code
* Cardiovascular history including Ii.e. known heart rhythm disorders
* Chronic disease: diabetes, high blood pressure...
* Long-term drug therapies that may modify cardiovascular remodeling such as Conversion Enzyme Inhibitor, Angiotensin II Receptor Antagonist,
* Active smoking, even if occasional
* Contraindication to MRI

Primary outcomes:
measure: Aortic compliance in triathletes in mm2/mmHG
timeFrame: at baseline, at the fitness peak (6 to 10 months later) and at recovery (3 to 6 months after the fitness peak)
Secondary outcomes:
Other outcomes:
Locations:
city: Nancy
country: France
facility: Central Hospital
Study officials:
affiliation: CHRU de Nancy
name: Damien MANDRY, MD,PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: CHRU de Nancy
name: Anne-Charlotte DUPONT, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Dupont AC, Poussel M, Hossu G, Marie PY, Chenuel B, Felblinger J, Mandry D. Aortic compliance variation in long male distance triathletes: A new insight into the athlete's artery? J Sci Med Sport. 2017 Jun;20(6):539-542. doi: 10.1016/j.jsams.2016.10.009. Epub 2016 Oct 29.