Clinical trial NCT04742374: Effects of Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Official title: Comparison of the Effects of 2 Therapeutic Plasmapheresis Techniques: Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). A Monocentric Prospective Study With a Single-Case Experimental Design
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Keywords: Plasma exchange
Double filtration plasmapheresis
Lead sponsor: Centre Hospitalier Universitaire de Nīmes
Sponsor class: OTHER
First posted: 2021-02-08
Enrollment: 8
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Proof-of-concept, monocentric, prospective, Single-Case Experimental Design
Primary purpose: TREATMENT

Brief summary: CIDP, a rare disorder affecting young adults, causes gradual weakness of the limbs, areflexia and impaired sensory function. New CIDP phenotypes without antibodies but with modified cell profiles have been described. Treatments include corticotherapy, IVIg and plasmapheresis but the latter's action mechanisms remain unclear. Plasmapheresis supposedly removes toxic agents like antibodies from plasma but it is uncertain whether it has an immune-modulating effect. Also, the refining mechanisms of the two main plasmapheresis techniques - single plasma exchange and double filtration plasmapheresis (DFPP) - are different and unclear. This study aims to compare the evolution of peripheral lymphocyte profiles in patients with CIDP according to their treatment (single centrifugation plasmapheresis or DFPP) to better grasp the action mechanisms of both techniques.


Eligibility criteria: Inclusion Criteria:

* Patients with confirmed Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) without pathogenic antibodies and stable under therapeutic plasmapheresis with one session every 2-3 weeks for at least two months.
* Patients who have given free written informed consent.
* Patients who have signed the consent form.
* Patients affiliated to or beneficiaries of a health insurance scheme.
* Adult patients (≥18 ans).
* Healthy subjects of the same age and sex

Exclusion Criteria:

* Patients Under the age of 18.
* Patients under immunosuppressive treatment for less than 3 months.
* Patients participating in Category 1 research involving human subjects.
* Patients in an exclusion period determined by another study.
* Patients under legal protection, guardianship or curatorship.
* Patients unable to express consent.
* Patients for whom it is impossible to give informed information.
* Pregnant, parturient or breastfeeding patients.
* Healthy subject with chronic pathology or drug treatment

Primary outcomes:
measure: Cycle 1, Group A : TH1 cells BEFORE single plasma exchange
timeFrame: Day 0, Time 0
measure: Cycle 1, Group A : TH1 cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 1, Group A : TH1 cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7 -10
measure: Cycle 1, Group A : TH17 cells BEFORE first single plasma exchange
timeFrame: Day 0, Time 0
measure: Cycle 1, Group A : TH17 cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 1, Group A : TH17 cells 7 - 10 days AFTER single plasma exchange
timeFrame: Day 7 - 10
measure: Cycle 1, Group A : T-reg cells BEFORE first single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 1, Group A : T-reg cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 1, Group A : T-reg cells 7 - 10 days AFTER single plasma exchange
timeFrame: Day 7 - 10
measure: Cycle 1, Group B : TH1 cells BEFORE first double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 1, Group B : TH1 cells AFTER the first double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 1, Group B : TH1 cells 7-10 days AFTER the first double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 1, Group B : TH17 cells BEFORE the first double filtration plasmapheresis
timeFrame: Day0, Hour 0
measure: Cycle 1, Group B : TH17 cells AFTER the first double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 1, Group B : T17 cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 1, Group B : T-reg cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 1, Group B : T-reg cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 1, Group B : T-reg cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 2, Group A: TH1 cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 2, Group A: TH1 cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 2, Group A: TH1 cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 2, Group A: TH17 cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 2, Group A: TH17 cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 2, Group A: TH17 cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 2, Group A: T-reg cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 2, Group A: T-reg cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 2, Group A: T-reg cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 2, Group B: TH1 cells BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 2, Group B: TH1 cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 2, Group B: TH1 cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 2, Group B: T17 cells BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 2, Group B: TH17 cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 2, Group B: TH17 cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 2, Group B: T-reg cells BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 2, Group B: T-reg cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 2, Group B: T-reg cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 3, Group A: TH1 cells BEFORE single plasma exchange
timeFrame: Day 1, Hour 1
measure: Cycle 3, Group A: TH1 cells AFTER single plasma exchange
timeFrame: Day 1, Hour 3
measure: Cycle 3, Group A: T1 cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7 - 10
measure: Cycle 3, Group A: TH17 cells BEFORE single plasma exchange
timeFrame: Day 1, Hour 1
measure: Cycle 3, Group A: TH17 cells AFTER single plasma exchange
timeFrame: Day 1, Hour 3
measure: Cycle 3, Group A: TH17 cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7 - 10
measure: Cycle 3, Group A: T-reg cells BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 3, Group A: T-reg cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 3, Group A: T-reg cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 3, Group B: TH1 cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 3, Group B: TH1 cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 3, Group B: TH1 cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 3, Group B: TH17 cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 3, Group B: TH17 cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 3, Group B: TH17 cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 3, Group B: T-reg cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 3, Group B: T-reg cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 3, Group B: T-reg cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 4, Group A: T1 cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 4, Group A: T1 cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 4, Group A: TH1 cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 4, Group A: TH17 cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 4, Group A: TH17 cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 4, Group A: TH17 cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 4, Group A: T-reg cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 4, Group A: T-reg cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 4, Group A: T-reg cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 4, Group B : TH1 cells BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 4, Group B : TH1 cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 4, Group B : TH1 cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7 -10
measure: Cycle 4, Group B : TH17 cells BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 4, Group B : TH17 cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 4, Group B : T17 cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7 -10
measure: Cycle 4, Group B : T-reg cells BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 4, Group B : T-reg cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 4, Group B : T-reg cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7 - 10
measure: Cycle 5, Group A : TH1 cells BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group A : TH1 cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group A : TH1 cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7 - 10
measure: Cycle 5, Group A : TH17 cells BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group A : TH17 cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group A : TH17 cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7 - 10
measure: Cycle 5, Group A : T-reg cells BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group A : T-reg cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group A : T-reg cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7 - 10
measure: Cycle 5, Group B : TH1 cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group B : TH1 cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group B : TH1 cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 5, Group B : TH17 cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group B : TH17 cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group B : TH17 cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 5, Group B : T-reg cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group B : T-reg cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group B : T-reg cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 6, Group A : TH1 cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 6, Group A : TH1 cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 6, Group A : TH1 cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 6, Group A : TH17 cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 6, Group A : TH17 cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 6, Group A : TH17 cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 6, Group A : T-reg cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 6, Group A : T-reg cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 6, Group A : T-reg cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 6, Group B : TH1 cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 6, Group B : TH1 cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 6, Group B : TH1 cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 6, Group B : TH17 cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 6, Group B : TH17 cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 6, Group B : TH17 cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 6, Group B : T-reg cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 6, Group B : T-reg cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 6, Group B : T-reg cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
Secondary outcomes:
measure: Cycle 1, Group A : T4 lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group A : T4-DR+ lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group A : T8 lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group A : B lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group A : CD45RA+CCR7+ cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group A : CD45RA-CCR7+ cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group A : CD45RA-CCR7- cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group A : T4 lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group A : T4-DR+ lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group A : T8 lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group A : T8 DR+ lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group A : B lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group A : CD45RA-CCR7- cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group A : CR6-CXCR3- cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group A : T4 lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 1, Group A : T4-DR+ lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 1, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 1, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 1, Group A : B lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 1, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 1, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 1, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 1, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 1, Group B: T4 lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group B: T4 DR+ lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group B: T8 lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group B: T8 DR+ lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group B: B lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group B: CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group B: CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group B: CD45RA-CCR7- cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group B: CCR6-CXCR3- cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 1, Group B:T4 lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group B:T4 DR+ lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group B:T8 lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group B:T8 DR+ lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group B: B lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group B: CD45RA+CCR7+ cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group B: CD45RA-CCR7+ cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group B: CD45RA-CCR7- cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group B: CCR6-CXCR3- cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 1, Group B: T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 1, Group B: T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 1, Group B: T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 1, Group B: T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 1, Group B: B lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 1, Group B: CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 1, Group B: CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 1, Group B: CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 1, Group B: CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 2, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group A : B lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group A : T4 lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group A : T8 lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group A : B lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 2, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 2, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 2, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 2, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 2, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 2, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 2, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 2, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7 - 10
measure: Cycle 2, Group B : T4 lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group B : T4 DR+ lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group B : T8 lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group B : B lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 2, Group B : T4 lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group B : T4 DR+ lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group B : T8 lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group B : T8 DR+ lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group B : B lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group B : CD45RA-CCR7- cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group B : CCR6-CXCR3- cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 2, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 2, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 2, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 2, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 2, Group B : B lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 2, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 2, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 2, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 2, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 3, Group A : T4 lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group A : T4 DR+ lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group A : T8 lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group A : B lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group A : CC45RA+CCR7+ cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group A : CC45RA-CCR7+ cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group A : CC45RA-CCR7- cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group A : T4 lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group A : T4 DR+ lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group A : T8 lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group A : T8 DR+ lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group A : B lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group A : CD45RA-CCR7- cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group A : CCR6-CXCR3- cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group A : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 3, Group A : T4 lymphocytes 7 -10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 3, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 3, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 3, Group A : B lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 3, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 3, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 3, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 3, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 3, Group B : T4 lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group B : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group B : T8 lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group B : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group B : B lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group B : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group B : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group B : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group B : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 3, Group B : T4 lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group B : T4 DR+ lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group B : T8 lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group B : T8 DR+ lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group B : B lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group B : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group B : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group B : CD45RA-CCR7- cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group B : CCR6-CXCR3- cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 3, Group B : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 3, Group B : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 3, Group B : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 3, Group B : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 3, Group B : B lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 3, Group B : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 3, Group B : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 3, Group B : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 3, Group B : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 4, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group A : B lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group A : T4 lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group A : T8 lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group A : B lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 4, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 4, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 4, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 4, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 4, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 4, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 4, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 4, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 4, Group B : T4 lymphocytes BEFORE plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group B : T4 DR+ lymphocytes BEFORE plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group B : T8 lymphocytes BEFORE plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group B : B lymphocytes BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange
timeFrame: Day 0 Hour 0
measure: Cycle 4, Group B : T4 lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group B : T4 DR+ lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group B : T8 lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group B : T8 DR+ lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group B : B lymphocytes AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group B : CD45RA-CCR7- cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group B : CCR6-CXCR3- cells AFTER single plasma exchange
timeFrame: Day 0 Hour 3
measure: Cycle 4, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 4, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 4, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 4, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 4, Group B : B lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 4, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 4, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 4, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 4, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 5, Group A : T4 lymphocytes BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group A : T4 DR+ lymphocytes BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group A : T8 lymphocytes BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group A : B lymphocytes BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group A : CD45RA+CCR7+ cells BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group A : CD45RA-CCR7+ cells BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group A : CD45RA-CCR7- cells BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group A : T4 lymphocytes AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group A : T4 DR+ lymphocytes AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group A : T8 lymphocytes AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group A : T8 DR+ lymphocytes AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group A : B lymphocytes AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group A : CD45RA-CCR7- cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group A : CCR6-CXCR3- cells AFTER single plasma exchange
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group A : T4 lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 5, Group A : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 5, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 5, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 5, Group A : B lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 5, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 5, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 5, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 5, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 5, Group B : T4 lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group B : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group B : T8 lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group B : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group B : B lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group B : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group B : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group B : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group B : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 5, Group B : T4 lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group B : T4 DR+ lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group B : T8 lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group B : T8 DR+ lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group B : B lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group B : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group B : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group B : CD45RA-CCR7- cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group B : CCR6-CXCR3- cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 5, Group B : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 5, Group B : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 5, Group B : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 5, Group B : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 5, Group B : B lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 5, Group B : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 5, Group B : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 5, Group B : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 5, Group B : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 6, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 6, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 6, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 6, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 6, Group A : B lymphocytes BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 6, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 6, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 6, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 6, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis
timeFrame: Day 0, Hour 0
measure: Cycle 6, Group A : T4 lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 6, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 6, Group A : T8 lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 6, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 6, Group A : B lymphocytes AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 6, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 6, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 6, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 6, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis
timeFrame: Day 0, Hour 3
measure: Cycle 6, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 6, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 6, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 6, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 6, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 6, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 6, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 6, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 6, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis
timeFrame: Day 7-10
measure: Cycle 6, Group B : T4 lymphocytes BEFORE single plasma exchange
timeFrame: Day 0, H0
measure: Cycle 6, Group B : T4 DR+ lymphocytes BEFORE single plasma exchange
timeFrame: Day 0, H0
measure: Cycle 6, Group B : T8 lymphocytes BEFORE single plasma exchange
timeFrame: Day 0, H0
measure: Cycle 6, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange
timeFrame: Day 0, H0
measure: Cycle 6, Group B : B lymphocytes BEFORE single plasma exchange
timeFrame: Day 0, H0
measure: Cycle 6, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange
timeFrame: Day 0, H0
measure: Cycle 6, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange
timeFrame: Day 0, H0
measure: Cycle 6, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange
timeFrame: Day 0, H0
measure: Cycle 6, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange
timeFrame: Day 0, H0
measure: Cycle 6, Group B : T4 lymphocytes AFTER single plasma exchange
timeFrame: Day 0, H3
measure: Cycle 6, Group B : T4 DR+ lymphocytes AFTER single plasma exchange
timeFrame: Day 0, H3
measure: Cycle 6, Group B : T8 lymphocytes AFTER single plasma exchange
timeFrame: Day 0, H3
measure: Cycle 6, Group B : T8 DR+ lymphocytes AFTER single plasma exchange
timeFrame: Day 0, H3
measure: Cycle 6, Group B : B lymphocytes AFTER single plasma exchange
timeFrame: Day 0, H3
measure: Cycle 6, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange
timeFrame: Day 0, H3
measure: Cycle 6, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange
timeFrame: Day 0, H3
measure: Cycle 6, Group B : CD45RA-CCR7- cells AFTER single plasma exchange
timeFrame: Day 0, H3
measure: Cycle 6, Group B : CCR6-CXCR3- cells AFTER single plasma exchange
timeFrame: Day 0, H3
measure: Cycle 6, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 6, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 6, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 6, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 6, Group B : B lymphocytes 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 6, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 6, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 6, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
measure: Cycle 6, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange
timeFrame: Day 7-10
Other outcomes:
measure: Group A, Cycle 1 : Link between variations in lymphocyte sub-populations and the clinical evolution .
timeFrame: Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
measure: Group B, Cycle 1 : Link between variations in lymphocyte sub-populations and the clinical evolution .
timeFrame: Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
measure: Group A, Cycle 2 : Link between variations in lymphocyte sub-populations and the clinical evolution .
timeFrame: Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
measure: Group B, Cycle 2 : Link between variations in lymphocyte sub-populations and the clinical evolution .
timeFrame: Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
measure: Group A, Cycle 3 : Link between variations in lymphocyte sub-populations and the clinical evolution .
timeFrame: Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
measure: Group B, Cycle 3 : Link between variations in lymphocyte sub-populations and the clinical evolution .
timeFrame: Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
measure: Group A, Cycle 4 : Link between variations in lymphocyte sub-populations and the clinical evolution .
timeFrame: Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
measure: Group B, Cycle 4 : Link between variations in lymphocyte sub-populations and the clinical evolution .
timeFrame: Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
measure: Group A, Cycle 5 : Link between variations in lymphocyte sub-populations and the clinical evolution .
timeFrame: Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
measure: Group B, Cycle 5 : Link between variations in lymphocyte sub-populations and the clinical evolution .
timeFrame: Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
measure: Group A, Cycle 6 : Link between variations in lymphocyte sub-populations and the clinical evolution .
timeFrame: Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
measure: Group B, Cycle 6 : Link between variations in lymphocyte sub-populations and the clinical evolution .
timeFrame: Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
measure: Group A, Cycle 1 : Cost of single plasma exchange to the health institution.
timeFrame: Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
measure: Group B, Cycle 1 : Cost of double filtration plasmapheresis to the health institution.
timeFrame: Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
measure: Group A, Cycle 2 : Cost of double filtration plasmapheresis to the health institution.
timeFrame: Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
measure: Group B, Cycle 2 : Cost of single plasma exchange to the health institution.
timeFrame: Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
measure: Group A, Cycle 3 : Cost of single plasma exchange to the health institution.
timeFrame: Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
measure: Group B, Cycle 3 : Cost of double filtration plasmapheresis to the health institution.
timeFrame: Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
measure: Group A, Cycle 4 : Cost of double filtration plasmapheresis to the health institution.
timeFrame: Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
measure: Group B, Cycle 4 : Cost of single plasma exchange to the health institution.
timeFrame: Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
measure: Group A, Cycle 5 : Cost of single plasma exchange to the health institution.
timeFrame: Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
measure: Group B, Cycle 5 : Cost of double filtration to the health institution.
timeFrame: Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
measure: Group A, Cycle 6 : Cost of double filtration to the health institution.
timeFrame: Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
measure: Group B, Cycle 6 : Cost of double filtration to the health institution.
timeFrame: Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
measure: Constitution of a biological resource centre using the blood samples taken in view of future research, especially immunological phenotyping.
timeFrame: Day 0, Hour 0
measure: Constitution of a biological resource centre using the blood samples taken in view of future research, especially immunological phenotyping.
timeFrame: Day 0, Hour 3
measure: Constitution of a biological resource centre using the blood samples taken in view of future research, especially immunological phenotyping.
timeFrame: Day 7-10
measure: Compare lymphocyte phenotype between patients with PIDC and control subjects.
timeFrame: Day 0
Locations:
city: Nîmes
country: France
facility: Olivier MORANNE
Study officials:
References:
citation: Moranne O, Ion IM, Cezar R, Messikh Z, Prelipcean C, Chkair S, Thouvenot E, Tran TA, Corbeau P, Chevallier T. Protocol of comparison of the effects of single plasma exchange and double filtration plasmapheresis on peripheral lymphocyte phenotypes in patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy: a monocentric prospective study with single-case experimental design. BMC Neurol. 2022 Aug 5;22(1):293. doi: 10.1186/s12883-022-02816-w.