Clinical trial NCT06664567: Impact of a Proactive Strategy of General Practitioners on CRC Screening
Official title: Impact of a Proactive Strategy of General Practitioners on CRC Screening: a Registry-based Cluster-based Randomized Controlled Trial
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer
Keywords: colorectal cancer screening
general practitioner
social health inequalities
Lead sponsor: University Hospital, Bordeaux
Sponsor class: OTHER
First posted: 2024-10-29
Enrollment: 26260
Sex: ALL
Minimum age (years): 50
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patient between 50 and 74 years old

Brief summary: In this registry-based cluster randomized controlled trial, we will assess the impact of a proactive strategy of general practitioners (GP) who will systematically provide screening kits of colorectal cancer (CRC) to all patients of even age (50, 52, 54...up to 74 years) versus usual practice where the eligible population receive an invitation letter to visit the general practitioner and receive the screening kit.

Detailed description: Colorectal cancer is one of the leading causes of cancer and death in France in both men and women. The generalized screening rate is about 30% in France, far from the expected 65%, despite the fact that screening is free and a letter of invitation is sent to the individual's home, and despite the financial incentives provided to the practitioner. Different studies have looked for the causes of non-implementation by the individual: negligence, "dirty"; forgetfulness, and the practitioner: organizational problem, communication problem. A few intervention studies have been carried out with little success: sending the invitation to the individual's home, sending a letter of reminder, sending a letter of general information on screening to the practitioner, sending the list of patients who have not taken the test to the practitioner allows for a few percent improvement in screening. In this registry-based cluster randomized controlled trial, we will assess the impact of a proactive strategy of general practitioners who will systematically provide screening kits of colorectal cancer to all patients of even age (50, 52, 54 years...up to 74 years) versus usual practice where the eligible population receive an invitation letter to visit the general practitioner and receive the screening kit. The screening rate will be calculated for each arm at the end of the 2-year study with data from the health insurance.

Eligibility criteria: inclusion criteria:

- medical practices in Aquitaine region and their visiting patients eligible for colorectal cancer screening individuals aged between 50 and 74 years at intermediate risk of colorectal cancer).

Exclusion criteria:

* medical practices with less than five individual eligible for colorectal cancer screening.
* visiting patients aged less than 50 years or more than 74 years or at high or very high risk of colorectal cancer.

Primary outcomes:
measure: Participation rate in CRC screening
timeFrame: 2 years after the start of protocol
Secondary outcomes:
measure: Positive test results
timeFrame: 2 years after the start of protocol
measure: Positive test at an early stage
timeFrame: 2 years after the start of protocol
measure: Positive test at a last stage
timeFrame: 2 years after the start of protocol
Other outcomes:
Locations:
Study officials:
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