Clinical trial NCT03679026: The "Motoric Cognitive Risk" Syndrome in the Canadian Population
Official title: The "Motoric Cognitive Risk" Syndrome in the Canadian Population: Analysis of Baseline Assessment of the Canadian Longitudinal Study on Aging (CLSA)
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Cognition Disorders in Old Age
Cardiovascular Diseases
Dementia
Lead sponsor: Jewish General Hospital
Sponsor class: OTHER
First posted: 2018-09-20
Enrollment: 1461
Sex: ALL
Minimum age (years): 45
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Individuals eligible for this study will be participants of the comprehensive Canadian Longitudinal Study on Aging (n=30,097). They are separated in four age groups (i.e.; 45-54, 54-64, 65-74 and 75-85). Each group will be divided in two subgroups: individuals with and without cardio-vascular risk factors and diseases.

Brief summary: Cognition and locomotion are two human abilities controlled by the brain. Their decline is highly prevalent with aging, and is greater than the simple sum of their respective prevalence, suggesting a complex age-related interplay between cognition and locomotion. Recently, a systematic review and meta-analysis has provided evidence that poor gait performance predicts dementia and, in particular, has demonstrated that "motoric cognitive risk" (MCR) syndrome, which has been described in cognitively healthy individuals and combines subjective cognitive complaint with objective slow gait speed, is a pre-dementia syndrome. The uniqueness of "motoric cognitive risk" (MCR)syndrome is that it does not rely on a complex evaluation or laboratory investigations. Thus, it is easy to apply in population-based settings. The overall objective of the proposal is to examine the epidemiology of the newly reported "motoric cognitive risk" (MCR) syndrome, in the Quebec population using the database of the NuAge study.


Eligibility criteria: Inclusion Criteria:

* Individuals eligible for this study will be participants of the NuAge study

Exclusion Criteria:

* Individuals not eligible for the NuAge study
* dementia
* mobility disability
* no information about cognitive complaint
* no measure of walking speed

Primary outcomes:
measure: Cardio-vascular risk factors and diseases assessed using reported health condition
timeFrame: 1 day
Secondary outcomes:
measure: Cardio-vascular risk factors and diseases assessed using physical examination: BMI
timeFrame: 1 day
measure: Cardio-vascular risk factors and diseases assessed using physical examination: HW ratio
timeFrame: 1 day
measure: Cardio-vascular risk factors and diseases assessed using physical examination: blood pressure
timeFrame: 1 day
measure: Disability and functional limitations
timeFrame: 1 day
measure: Disability and functional limitations
timeFrame: 1 day
measure: Disability and functional limitations
timeFrame: 12 months
measure: Depression
timeFrame: 1 day
measure: Cognitive performance
timeFrame: 1 day
measure: Cognitive performance
timeFrame: 1 day
measure: Cognitive performance
timeFrame: 1 day
measure: Cognitive performance
timeFrame: 1 day
measure: physical and mental health
timeFrame: 1 day
measure: physical and mental health
timeFrame: 1 day
measure: Physical performance
timeFrame: 1 day
measure: Physical performance
timeFrame: 1 day
measure: Physical performance
timeFrame: 1 day
Other outcomes:
Locations:
city: Montréal
country: Canada
facility: Jewish General Hospital
state: Quebec
Study officials:
References: