Clinical trial NCT05047367: The Relationship of Psychological Factors and Sleep Quality With the Severity of Carpal Tunnel Syndrome
Official title: The Relationship of Psychological Factors and Sleep Quality With the Severity of Carpal Tunnel Syndrome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Depressive Symptoms
Sleepiness
Anxiety
Sleep
Pain, Neuropathic
Keywords: CTS,Psychological factors,Sleep quality,Daytime Sleepiness
Lead sponsor: Cumhuriyet University
Sponsor class: OTHER
First posted: 2021-09-17
Enrollment: 149
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients diagnosed with CTS

Brief summary: The most common entrapment neuropathy symptoms, the diagnosis of CTS, is determined by examination findings and by means of the results of electro-diagnostic test. With an increase in disease severity, trap neuropathy, whose symptoms are more pronounced at night, negatively affects the daily life of the person. Deterioration in sleep quality may cause depression and anxiety. Conflicting results have been found in the studies related to these findings. However, no study was found in which daytime sleepiness was evaluated in terms of CTS. The investigators aim in this study is to evaluate the relationship between CTS severity and depression, anxiety, sleep quality and daytime sleepiness.

Detailed description: Carpal tunnel syndrome (CTS) is the most common peripheral neuropathy with an incidence of 2.7-4%. CTS, resulting from compression of the median nerve in the wrist, clinically progresses with tingling, numbness matching the nerve trace, and motor deficit in the presence of progressive nerve damage. Accordingly, the incidence of neuropathic pain is increasing. In addition to these symptoms mentioned, electro-diagnostic tests are used for diagnostic purposes and to determine the severity of nerve compression, and as a result, there are different types of classification, but most commonly CTS is classified as mild, moderate and severe. This classification is of great importance for the regulation of the follow-up and treatment protocol and making the association of existing complaints with the disease. Studies have shown that approximately 80% of CTS patients wake up at night due to numbness in the hand, resulting in deterioration in sleep quality. Impairment of sleep quality may cause increased sympathetic nervous system activity and awakening of physical and psychological stressors. Deterioration in sleep quality may cause depression and anxiety. Conflicting results have been found in the studies related to these findings. However, no study was found in which daytime sleepiness was evaluated in terms of CTS. The investigators aim in this study is to evaluate the relationship between CTS severity and depression, anxiety, sleep quality and daytime sleepiness. This study;149 patients with a diagnosis of CTS were prospectively included in the study. Electro-diagnostic test results were used to determine the severity of the disease. In this context, Boston CTS rating scale was used to evaluate the functional and symptomatic effects, Pittsburgh sleep quality scale and Epworth sleepiness scale were used to evaluate sleep quality and daytime sleepiness, and pain DETECT questionnaire was used to evaluate pain type.

Eligibility criteria: Inclusion Criteria:

* Patients aged 18-75 years diagnosed with CTS.
* Patients who were mentally able to respond to the assessment questionnaires were also included

Exclusion Criteria:

* Clinical diagnosis of cervical radiculopathy/plexopathy findings
* Pregnancy
* Diabetes mellitus
* thyroid diseases
* amyloidosis
* collagen tissue diseases
* Obstructive sleep apnea
* History of the upper extremity trauma

Primary outcomes:
measure: Severity of Carpal Tunnel Syndrome
timeFrame: study completion,an average of six months
measure: The correlation between severity of Carpal Tunnel Syndrome and psychological evaluation
timeFrame: study completion,an average of six months
measure: The correlation between severity of Carpal Tunnel Syndrome and pain intensity
timeFrame: study completion,an average of six months
measure: The correlation between severity of Carpal Tunnel Syndrome and neuropathic pain
timeFrame: study completion,an average of six months
measure: The correlation between severity of Carpal Tunnel Syndrome and sleep quality
timeFrame: study completion,an average of six months
measure: The correlation between severity of Carpal Tunnel Syndrome and sleepiness
timeFrame: study completion,an average of six months
Secondary outcomes:
Other outcomes:
Locations:
city: Sivas
country: Turkey
facility: Emel Guler
Study officials:
References:
citation: Rubin G, Orbach H, Rinott M, Rozen N. Relationship between electrodiagnostic findings and sleep disturbance in carpal tunnel syndrome: A controlled objective and subjective study. J Int Med Res. 2020 Feb;48(2):300060519862673. doi: 10.1177/0300060519862673. Epub 2019 Jul 18.