Clinical trial NCT06505343: Effect of Freezing Phenomenon in Patients With Parkinson's Disease
Official title: Investigation of the Effect of Freezing Phenomenon on Gait Parameters and Pedobarographic Pressure Distribution in Patients With Parkinson's Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Patients With Parkinson's Disease
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2024-07-17
Enrollment: 43
Sex: ALL
Minimum age (years): 50
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with Parkinson's disease

Brief summary: Although the literature review indicates that plantar pressure may be related to freezing, there are not enough studies examining the effect of freezing phenomenon on pedobarographic pressure distribution and gait parameters. Therefore, the aim of our study is to examine the effect of freezing phenomenon on gait parameters and pedobarographic pressure distribution in patients with Parkinson's Disease.

Detailed description: Individuals diagnosed with Idiopathic Parkinson's disease by a physician and healthy individuals with similar demographic characteristics will be included in the study. Individuals will be examined in 3 groups: a group of patients with Parkinson's Disease with freezing phenomenon, a group of patients with Parkinson's Disease without freezing phenomenon, and a healthy control group.

Eligibility criteria: Inclusion Criteria:

* Volunteering to participate in the study
* Being between stage 2-3 according to the Modified Hoehn-Yahr Staging Scale
* Having a score of 24 or above from the Standardized Mini Mental Test

Exclusion Criteria:

* Presence of an additional neurological or psychiatric disease other than Parkinson's disease
* Presence of uncontrollable dyskinesia or motor fluctuations
* Presence of postural hypotension, vision problems (that cannot be compensated with the correct lens) or vestibular disorders that may affect balance
* Presence of cardiopulmonary diseases that may affect walking
* Presence of orthopedic problems and inflammatory arthritis (such as fractures, osteoporosis, osteomyelitis) that may cause limitation of movement and affect gait and evaluations

Primary outcomes:
measure: Computerized Gait Evaluation System
timeFrame: Baseline
measure: Pressure distribution measurement platform
timeFrame: Baseline
measure: Kinematic analysis
timeFrame: Baseline
measure: The freezing of gait questionnaire
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hacettepe University
Study officials:
affiliation: Atılım University
name: Süleyman Korkusuz, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Ankara University
name: Büşra Seçkinoğulları Korkusuz, MSc
role: STUDY_CHAIR
affiliation: Çankırı Karatekin University
name: Ayşenur Özcan
role: STUDY_CHAIR
affiliation: Hacettepe University
name: Emine Nur Demircan, Msc
role: STUDY_CHAIR
affiliation: European University of Lefke
name: Ferdi Yavuz, Assoc.Prof
role: STUDY_CHAIR
affiliation: Hacettepe University
name: Bülent Elibol, Prof.Dr.
role: STUDY_CHAIR
affiliation: Hacettepe University
name: Gül Yalçın Çakmaklı, Assoc.Prof
role: STUDY_CHAIR
affiliation: Hacettepe University
name: Ayla Fil Balkan, Assoc.Prof
role: STUDY_CHAIR
References:
citation: Morris ME, Iansek R, Matyas TA, Summers JJ. The pathogenesis of gait hypokinesia in Parkinson's disease. Brain. 1994 Oct;117 ( Pt 5):1169-81. doi: 10.1093/brain/117.5.1169.
citation: Giladi N, Nieuwboer A. Understanding and treating freezing of gait in parkinsonism, proposed working definition, and setting the stage. Mov Disord. 2008;23 Suppl 2:S423-5. doi: 10.1002/mds.21927. No abstract available.