Clinical trial NCT01693926: Effect of Physical Activity an Stress in Children
Official title: Effect of Physical Activity an Stress in Children
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Children
Physical Activity
Stress
Snacking
Keywords: Obesity
Children
Physical activity
Stress
Snacking
Lead sponsor: University of Lausanne Hospitals
Sponsor class: OTHER
First posted: 2012-09-26
Enrollment: 50
Sex: ALL
Minimum age (years): 7
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of the study is to evaluate the impact of physical activity in obese and nonobese prepubertal children on:

1. biological stress responses during a psychosocial stress test
2. snacking and feeling of hunger in response to the same psychosocial stress test
3. the moderating factor of attachment on the biological stress responses and on snacking

Children will be investigated on one study day during 3.5 hours.

Detailed description: Hypotheses In this study, 3 primary hypotheses will be tested.

1. Moderate physical activity during 25 min in children decreases the cortisol levels in response to the Trier Social Stress Test TSST-C (for children).
2. Moderate physical activity during 25 min in children decreases the snacking (calorie consumption when corrected for expenditure and switch in quality of food intake) in response to the Trier Social Stress Test TSST-C (for children).
3. A secure attachment will be a moderating factor for the general increase in cortisol and the snacking in response to the psychosocial stress test (Trier Social Stress Test TSST-C).

Secondary objectives:

1. To test if the impact of physical activity on stress responses and snacking differs between obese and non-obese children
2. To test the impact of physical activity on the cardiovascular stress reactivity (blood pressure, heart rate) and the perceived stress (scale) in response to the Trier Social Stress Test TSST-C?
3. To test if the stress reactivity and its modulation by physical activity is different in anxious and in impulsives/labile children
4. To test if serious life events and parental worries and parental educational style influence the stress reactivity

Eligibility criteria: Inclusion Criteria:

* 7-10 year old children

Exclusion Criteria:

* Severe illness
* Medications interfering with study

Primary outcomes:
measure: Change in salivary Cortisol and maximal levels of salivary cortisol in response to the TSST stress test over 2 hours
timeFrame: 9 months
measure: Snacking (Caloric intake, corrected for energy expenditure)
timeFrame: 9 months
measure: Moderator effect of attachment (4 different attachment categories), i.e. children with a secure attachment will have lower rises in cortisol compared with children in the other 3 attachment categories
timeFrame: 9 months
Secondary outcomes:
measure: Moderator effect of obesity (WHO criteria)
timeFrame: 9 months
measure: Cardiovascular reactivity (changes and maximal levels of blood pressure, heart rate)
timeFrame: 9 months
measure: Perceived stress (stress scale from 1-7)
timeFrame: 9 months
measure: Moderator role of serious life events and parental worries
timeFrame: 9 months
Other outcomes:
Locations:
city: Lausanne
country: Switzerland
facility: Univeristy of Lausanne, SUPEA
state: VD
Study officials:
References:
citation: Horsch A, Wobmann M, Kriemler S, Munsch S, Borloz S, Balz A, Marques-Vidal P, Borghini A, Puder JJ. Impact of physical activity on energy balance, food intake and choice in normal weight and obese children in the setting of acute social stress: a randomized controlled trial. BMC Pediatr. 2015 Feb 19;15:12. doi: 10.1186/s12887-015-0326-7.