Clinical trial NCT06096662: Effects of Verb Network Strengthening Treatment (VNeST) Via Telerehabilitation on Word Finding in Post-stroke Aphasia.
Official title: Effects of Verb Network Strengthening Treatment (VNeST) Provided Via Telerehabilitation on Word Finding in Individuals With Post-stroke Aphasia: a Group Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aphasia
Anomia
Stroke
Lead sponsor: Vastra Gotaland Region
Sponsor class: OTHER_GOV
Collaborators: name: The Swedish Research Council
First posted: 2023-10-24
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Parallel assignment
Primary purpose: TREATMENT

Brief summary: Despite evidence showing that speech and language intervention may improve language and communication abilities in people with acquired language disorders (aphasia), there is still need for evidence for which types of therapy are effective. Further, to improve accessibility of care, there is increasing need for evidence of intervention effects when therapy is provided online, via telerehabilitation. Therefore, the project aims at evaluating the effects of telerehabilitation with a specific speech-language therapy intervention for improving word-finding in individuals with aphasia due to stroke. The intervention Verb Network Strengthening Treatment (VNeST) trains word finding at sentence level, and the treatment effect is expected to generalize to the production of connected speech.

Detailed description: Every year in Sweden, thousands of people suffer from stroke, often resulting in aphasia. One of the most common and persistent symptoms in aphasia is anomia, i.e., word finding difficulties. Anomia affects an individual's ability to communicate and can constitute an obstacle to active participation in social activities and working life with reduced quality of life as consequence.

Speech and language therapy has proved to be effective with significant training outcomes for people with aphasia (Brady, Kelly, Godwin, Enderby, \& Campbell, 2016). However, concerning treatment of anomia a major challenge is to achieve generalization to untrained items and to connected speech. Most interventions train to name single words, with very little improvement in naming of untrained items, or generalization in daily language use (Kiran \& Thompson, 2003; Kristensson et al., 2022). Typically, word-finding therapies target nouns. Training effects of verbs have been reported to a lesser extent and found to be smaller than that of nouns (Webster \& Whitworth, 2012). Edmonds and coworkers (2009, 2011, 2014; Furnas \& Edmonds, 2014) have developed an intervention protocol called Verb Network Strengthening Treatment (VNeST) which aims at improving production of nouns and verbs in sentence context by stimulating retrieval of verbs and possible subjects/agents and objects/patients for the given verbs (e.g., "The pupil writes a letter"). So far, results from single-case experimental design studies performed by Edmonds and colleagues are promising, showing generalization to untrained items and to other tasks (object naming, verb naming, and partly connected speech). The same promising results were observed even when Verb Network Strengthening Treatment (VNeST) was delivered remotely via a computer program (Furnas \& Edmonds, 2014). In a single case experimental design study carried out by our group via telerehabilitation (Torinsson et al., submitted) in two individuals with mild-to-moderate and moderate-to-severe aphasia, we found that one participant improved significantly in word retrieval when producing sentences containing either trained verbs or semantically related verbs that were not targeted in treatment, suggesting generalization to untrained words. The other participant did not show any significant improvement for either trained or untrained items. Yet, an increase of production of correct information units (a measure of how informative verbal production is in an individual) could be observed in this participant four weeks after treatment. The results of this Swedish study seem to be in line with previous findings by Edmonds and colleagues. However, to our knowledge, the effects of intervention have not been investigated in larger groups of patients in a randomized controlled trial. Hence, this study aims to evaluate treatment effects of the VNeST protocol via telerehabilitation in individuals with post-stroke aphasia through a randomized controlled trial (RCT).

Outcome measures include measures of naming ability on word and sentence level as well as in connected speech. Measures of participant reported perception of functional communication as well as health related quality of life (PROMs) are also included.

Eligibility criteria: Inclusion Criteria:

* Aphasia and subjective experience of word finding difficulties
* Diagnosed left hemisphere stroke at least six months post-onset
* With correction, sufficient hearing and vision to be able to participate in training and assessment.
* Sufficient stamina to be able to participate in training and assessment.
* Swedish as one of the first languages.

Exclusion Criteria:

* Other known neurological conditions
* Untreated epilepsy
* Severely impaired comprehension
* Moderate-severe dysarthria or apraxia of speech which may interfere with assessment.
* Speech-language treatment targeting specifically word finding during participation in the study.
* Participation in other studies/clinical treatment using Verb Network Strengthening Treatment (VNeST) during three months prior to the study.
* Active substance dependence

Primary outcomes:
measure: Change from baseline in naming ability of trained items at week 10.
timeFrame: Baseline, 10 weeks
measure: Change from baseline in naming ability of trained items at week 14.
timeFrame: Baseline, 14 weeks
Secondary outcomes:
measure: Change from baseline in naming ability of untrained items at week 10.
timeFrame: Baseline, 10 weeks.
measure: Change from baseline in naming ability of untrained items at week 14.
timeFrame: Baseline, 14 weeks.
measure: Change from baseline in confrontation naming of single words (objects and actions) at week 10.
timeFrame: Baseline, 10 weeks.
measure: Change from baseline in confrontation naming of single words (objects and actions) at week 14.
timeFrame: Baseline, 14 weeks.
measure: Change from baseline in confrontation naming of single words (objects) at week 10.
timeFrame: Baseline, 10 weeks
measure: Change from baseline in confrontation naming of single words (objects) at week 14.
timeFrame: Baseline, 14weeks
measure: Change from baseline in connected speech at week 10.
timeFrame: Baseline, 10 weeks
measure: Change from baseline in connected speech at week 14.
timeFrame: Baseline, 14 weeks
measure: Change from baseline in self-perceived functional communication abilities at week 10
timeFrame: Baseline, 10 weeks
measure: Change from baseline in self-perceived functional communication abilities at week 14
timeFrame: Baseline, 14 weeks
measure: Change from baseline in proxy's reports of participants' communicative ability at week 10.
timeFrame: Baseline, 10 weeks
measure: Change from baseline in proxy's reports of participants' communicative ability at week 14.
timeFrame: Baseline, 14 weeks
measure: Change from baseline in self reported quality of life at week 10.
timeFrame: Baseline, 10 weeks
measure: Change from baseline in self reported quality of life at week 14.
timeFrame: Baseline, 14 weeks
Other outcomes:
Locations:
city: Gothenburg,
country: Sweden
facility: University of Gothenburg and Västra Götalandsregionen
state: Västra Götaland
Study officials:
affiliation: Inst of Neurosci & Physiology, Speech & Language Pathology Unit, University of Gothenburg
name: Francesca Longoni, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Brady MC, Kelly H, Godwin J, Enderby P, Campbell P. Speech and language therapy for aphasia following stroke. Cochrane Database Syst Rev. 2016 Jun 1;2016(6):CD000425. doi: 10.1002/14651858.CD000425.pub4.
citation: Edmonds LA, Babb M. Effect of verb network strengthening treatment in moderate-to-severe aphasia. Am J Speech Lang Pathol. 2011 May;20(2):131-45. doi: 10.1044/1058-0360(2011/10-0036). Epub 2011 Mar 8.
citation: Edmonds LA, Nadeau SE, Kiran S. Effect of Verb Network Strengthening Treatment (VNeST) on Lexical Retrieval of Content Words in Sentences in Persons with Aphasia. Aphasiology. 2009 Mar 1;23(3):402-424. doi: 10.1080/02687030802291339.
citation: Edmonds LA, Mammino K, Ojeda J. Effect of Verb Network Strengthening Treatment (VNeST) in persons with aphasia: extension and replication of previous findings. Am J Speech Lang Pathol. 2014 May;23(2):S312-29. doi: 10.1044/2014_AJSLP-13-0098.
citation: Goodglass, H., Kaplan, E., & Weintraub, S. (1983). Boston naming test. Philadelphia, PA: Lea & Febiger.
citation: Hilari K, Lamping DL, Smith SC, Northcott S, Lamb A, Marshall J. Psychometric properties of the Stroke and Aphasia Quality of Life Scale (SAQOL-39) in a generic stroke population. Clin Rehabil. 2009 Jun;23(6):544-57. doi: 10.1177/0269215508101729. Epub 2009 May 15.
citation: Kiran S, Thompson CK. The role of semantic complexity in treatment of naming deficits: training semantic categories in fluent aphasia by controlling exemplar typicality. J Speech Lang Hear Res. 2003 Aug;46(4):773-87. doi: 10.1044/1092-4388(2003/061).
citation: Kristensson J, Saldert C, Ostberg P, Smith SR, Ake S, Longoni F. Naming vs. non-naming treatment in aphasia in a group setting-A randomized controlled trial. J Commun Disord. 2022 May-Jun;97:106215. doi: 10.1016/j.jcomdis.2022.106215. Epub 2022 Mar 17.
citation: Long A, Hesketh A, Paszek G, Booth M, Bowen A. Development of a reliable self-report outcome measure for pragmatic trials of communication therapy following stroke: the Communication Outcome after Stroke (COAST) scale. Clin Rehabil. 2008 Dec;22(12):1083-94. doi: 10.1177/0269215508090091.
citation: Long A, Hesketh A, Bowen A; ACT NoW Research Study. Communication outcome after stroke: a new measure of the carer's perspective. Clin Rehabil. 2009 Sep;23(9):846-56. doi: 10.1177/0269215509336055. Epub 2009 May 29.
citation: Masterson, J., & Druks, J. (1998). Description of a set of 164 nounsand 102 verbs matched for printed word frequency, familiarityand age-of-acquisition. Journal of Neurolinguistics, 11(4), 331-354
citation: Nicholas LE, Brookshire RH. A system for quantifying the informativeness and efficiency of the connected speech of adults with aphasia. J Speech Hear Res. 1993 Apr;36(2):338-50. doi: 10.1044/jshr.3602.338.
citation: Torinsson, M., Saldert, C., Rödseth Smith, S., Kristensson, J., & Longoni, F. (2023). Telerehabilitation with Verb Network Strengthening Treatment (VNeST) in two persons with mild-to-moderate and moderate-to-severe aphasia: A single-case experimental design study. Submitted manuscript.
citation: Webster J, Whitworth A. Treating verbs in aphasia: exploring the impact of therapy at the single word and sentence levels. Int J Lang Commun Disord. 2012 Nov-Dec;47(6):619-36. doi: 10.1111/j.1460-6984.2012.00174.x. Epub 2012 Jul 18.