louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02700126: Impact of Genetic Polymorphism on Propofol Requirement and Recovery for Total Intravenous Anesthesia for Clipping of Unruptured Cerebral Aneurysm in Korean Population
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Unruptured Cerebral Aneurysm
Keywords: propofol
total intravenous anesthesia
cerebral aneurysm
single nucleotide polymorphism
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2016-03-07
Enrollment: 118
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Korean adult population undergoing propofol based total intravenous anesthesia for clipping of unruptured cerebral aneurysm.

Brief summary: In neurosurgical anesthesia, propofol based total intravenous anesthesia (TIVA) is frequently used due to brain relaxation and less effect on electrophysiologic monitoring. Response to propofol can vary between individuals and be associated with clinical factors including age and weight, and genetic polymorphism. Because the importance of rapid recovery in neurosurgery with long operation time is emphasized recently, the choice and dose adjustment of anesthetics should be determined according to clinical and genetic factors. Recently, researches about genetic variations have been performed with single nucleotide polymorphism (SNP). The aim of this study is to determine SNPs associated with propofol recovery and response in Korean adult population undergoing propofol based TIVA for clipping of unruptured cerebral aneurysm.


Eligibility criteria: Inclusion Criteria:

1. Korean adult population undergoing propofol based TIVA for clipping of unruptured cerebral aneurysm

Exclusion Criteria:

1. patients not able to read, or understand the consent form
2. ethnicity, other than Korean population
3. patients refusal
4. patients not to perform total intravenous anesthesia

Primary outcomes:
measure: Time of eye opening after stopping propofol infusion
timeFrame: within about one hour from end of surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine
Study officials:
References:
citation: Iohom G, Ni Chonghaile M, O'Brien JK, Cunningham AJ, Fitzgerald DF, Shields DC. An investigation of potential genetic determinants of propofol requirements and recovery from anaesthesia. Eur J Anaesthesiol. 2007 Nov;24(11):912-9. doi: 10.1017/S0265021507000476. Epub 2007 Jun 7.
Clinical trial NCT06897826: Effect of Hamstring Stretching on Cervical Flexor Muscle Endurance
Official title: Acute Effect of Hamstring Stretching Performed With Proprioceptive Neuromuscular Facilitation Technique on the Endurance of Neck Deep Flexor Muscles in Healthy Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: Deep Neck Flexors
Hamstrings
Superficial Back Line
proprioceptive neuromuscular stimulation
Lead sponsor: Abant Izzet Baysal University
Sponsor class: OTHER
First posted: 2025-03-27
Enrollment: 66
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 24
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: The superficial posterior line is one of the eight main fascial lines defined on the body. One of the important muscle groups on this line is the hamstring muscle group. Studies have shown that various stretching methods applied to the hamstring muscle group affect the cervical region both in terms of range of motion and posture. As a result of this study, it was shown that deep neck flexor endurance increased in women who applied the PNF hold-relax method.

Detailed description: The superficial posterior line is one of the eight main fascial lines defined on the body. One of the important muscle groups on this line is the hamstring muscle group. Studies have shown that various stretching methods applied to the hamstring muscle group affect the cervical region both in terms of range of motion and posture. Our aim in our study is to examine the effect of the proprioceptive neuromuscular stretching (PNF) method applied to the hamstring muscle group on the endura of the deep neck flexors based on these data.

Eligibility criteria: Inclusion Criteria:

* being female
* being healthy in musculoskeletal conditions

Exclusion Criteria:

* being hypermobile

Primary outcomes:
measure: Deep Neck Flexor Before and After
timeFrame: Two times in one day (before intervention, immediately after intervention)
Secondary outcomes:
Other outcomes:
Locations:
city: Bolu
country: Turkey
facility: Bolu Abant Izzet Baysal University
state: Merkez
Study officials:
affiliation: Abant Izzet Baysal University
name: Ömer Osman PALA, phd
role: STUDY_DIRECTOR
References:
Clinical trial NCT00352326: Optimizing Assisted Communication Devices for Children With Motor Impairments Using a Model of Information Rate and Channel Capacity
Official title: Optimizing Assisted Communication Devices for Children With Motor Impairments Using a Model of Information Rate and Channel Capacity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cerebral Palsy
Lead sponsor: University of Southern California
Sponsor class: OTHER
First posted: 2006-07-14
Enrollment: 29
Sex: ALL
Minimum age (years): 5
Maximum age (years): 25
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: For children who depend on devices to communicate, the rate of communication is a primary determinant of success. For children with motor impairments, the rate of communication may be limited by inability to contact buttons or cells rapidly or accurately. It is therefore essential to know how to adjust the device interface in order to maximize each child's rate of communication. The optimal rate of communication is determined by the Channel Capacity, which is the maximum value of the Information Rate for all possible keyboard button or cell layouts for the communication device. We construct a mathematical model for the information rate based on the relationship between movement time and the number of buttons per screen, the size of the buttons, and the length of a sequence of buttons that must be pressed to communicate each word in the vocabulary. We measure the parameters of the model using a custom-programmed touch-screen interface.


Eligibility criteria: Inclusion Criteria:- Use of Dynavox ability to follow two-step commands impairment in arm function Exclusion Criteria:- increased risks of study

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University School of Medicine
state: California
Study officials:
affiliation: Stanford University
name: Terence D. Sanger
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00249626: Therapists to Administer Contingency Management-Therapist Phase - 1
Official title: Therapists to Administer Contingency Management-Therapist Phase
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Substance Abuse
Keywords: Contingency management
substance abuse treatment
Lead sponsor: UConn Health
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
First posted: 2005-11-07
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: The purpose of this study is to train therapists to administer contingency management (CM). This project will train up to 42 community-based treatment providers about the rationale for and the specifics of administering CM. Initial training will occur in 2-day workshops, followed by weekly supervision in delivery of CM with test cases. We expect that the majority of therapists will achieve high levels of competence and adherence in administering CM treatment within 3-5 test cases, as measured by ratings of audiotapes. To examine the efficacy of CM, each therapist who achieves adherence and competence in delivering CM will administer standard treatment alone or standard treatment plus CM to substance-abusing outpatients. In the CM condition, patients will have the opportunity to win prizes for submission of negative samples, and the treatment will be in effect for 12 weeks. In total, up to 200 patients will be randomly assigned to one of the two conditions. A research evaluator will conduct follow-up assessments, scheduled for 3, 6 and 9 months after treatment initiation.


Eligibility criteria: Inclusion Criteria:

Therapists who volunteer must have:

* at least one-year experience treating substance abusers, and at least 6 months employment at that center
* must commit to being available for both the workshop and individual training
* must be willing to allow random assignment of their patients to CM and non-CM treatments

Primary outcomes:
measure: urinalysis results
timeFrame: baseline and at each follow-up
Secondary outcomes:
Other outcomes:
Locations:
city: Farmington
country: United States
facility: University of Connecticut Health Center
state: Connecticut
Study officials:
affiliation: UConn Health
name: Nancy Petry, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04608526: Relationship Between Tooth Decay and Trabecular Bone
Official title: Evaluation of the Relationship Between Tooth Decay and Trabecular Bone Structure in Pediatric Patients by Fractal Analysis Method: A Retrospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dental Caries in Children
Pediatric Patients
Radiology
Keywords: Disturbances in dental development
fractal analysis
pediatric patients
radiology
Lead sponsor: Recep Tayyip Erdogan University Training and Research Hospital
Sponsor class: OTHER
First posted: 2020-10-29
Enrollment: 120
Sex: ALL
Minimum age (years): 8
Maximum age (years): 13
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: * systemically healthy,
* 8-13 years-old,
* applied to the Clinic between January 2018 and April 2020 patients

Brief summary: Chewing, a movement that matures with experiences, has effects on the growth and development of the stomatognathic system. Tooth decay, which is known to have effects on chewing, can affect the jaw bone due to its indirect effect on the mechanical forces transmitted to the jaw bone. This study was aimed to evaluate the relationship between dental caries and jaw bone trabeculation during the growth and development processes in children by fractal dimension analysis method. 40 patients with deep-dentin caries / apical rarefying osteitis on the right or left side, 40 patients with deep-dentin caries / apical rarefying osteitis on either the right and left sides and 40 patients without deep-dentin caries / apical rarefying osteitis between 8-13 ages were randomly selected. Digital panoramic images of the selected patients were analyzed with fractal dimension analysis.


Eligibility criteria: Inclusion Criteria:

* Panoramic radiographs of systemically healthy 8-13 years-old patients,
* Who applied to the Clinic between January 2018 and April 2020 were retrospectively scanned.
* Patients with 1st molars whose root development was completed and the 2nd molars not erupted yet were included.

Exclusion Criteria:

* Patients with temporomandibular joint disorders, any systemic disease, exposed to trauma in the area to be measured, received orthodontic treatment for the last 2 years or had an ongoing orthodontic treatment, unilateral / bilateral cross-bite and had parafunctional habits in their anamnesis were excluded.

Primary outcomes:
measure: The effects of dental caries on the jawbone in children aged between 8-13 years
timeFrame: for two months from the beginning of the study
Secondary outcomes:
Other outcomes:
Locations:
city: Rize
country: Turkey
facility: Sema Aydinoğlu
Study officials:
affiliation: Recep Tayyip Erdogan University Training and Research Hospital
name: SEMA AYDINOĞLU
role: STUDY_DIRECTOR
References:
Clinical trial NCT00895726: Pilot Study of APD209 in Cancer Cachexia
Official title: Open-Label, Pilot Phase I/II Study of the Efficacy and Safety of APD209 in Patients With Cachexia and Advanced Malignancy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Cancer-related Cachexia
Keywords: cachexia
neoplasms
Lead sponsor: Acacia Pharma Ltd
Sponsor class: INDUSTRY
First posted: 2009-05-08
Enrollment: 13
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Primary Objective:

To assess the efficacy of APD209 in adult patients with active cachexia associated with advanced malignancy and not caused by simple starvation.

Secondary Objective:

To assess the safety of APD209 in patients with advanced malignancy and active cachexia.


Eligibility criteria: Inclusion Criteria:

* Involuntary loss of weight of \>= 2% in 2 months or \>= 5% in 6 months, and ongoing in recent weeks, without (or with successfully treated) secondary causes of impaired oral nutritional intake (simple starvation).

Primary outcomes:
measure: Muscle size and function
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Edinburgh
country: United Kingdom
facility: Royal Infirmary Edinburgh
Study officials:
affiliation: Acacia Pharma Ltd
name: Gabriel Fox, MB BChir
role: STUDY_DIRECTOR
References:
Clinical trial NCT01454726: Clinical Trial of Traditional Chinese Diaoshi Jifa Therapy of Meniere's Disease
Official title: A Random Controlled Clinical Trial:l Traditional Chinese Diaoshi Jifa Therapy of Meniere's Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Meniere's Disease
Keywords: Dizziness
Meniere's disease
Diaoshi Jifa therapy
Lead sponsor: Beijing Administration of Traditional Chinese Medicine Bureau
Sponsor class: OTHER_GOV
Collaborators: name: Beijing Hospital of Traditional Chinese Medicine
First posted: 2011-10-19
Enrollment: 27
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The hypothesis of this study is that DiaoShi Jifa reduces the symptoms, such as dizziness in patients with Meniere's disease.

Detailed description: Created by Dr. Diao, DiaoShi Jifa is a well-known traditional Chinese Medicine approach to treat dizziness in patients with chronic diseases. The investigators designed this randomized clinical trial to examine whether Diaoshi Jifa significantly decreases dizziness in patients with Meniere's disease. There are 2 arms in this trial: One arm is DiaoShi Jifa plus conventional Western medical treatment, another is conventional Western medical treatment only. The dizziness handicap inventory (DHI) will be used to evaluate the treatment effect.

Eligibility criteria: Inclusion Criteria:

1. Clinical diagnosis of probable Meniere's disease
2. Must be able to receive manual treatment
3. Dizziness Patients receiving other treatment longer than 5 days before entering the study.

Exclusion Criteria:

1. Patients with critical illness of internal medicine and surgery
2. Patients with spinal disease or other conditions that cannot receive manual treatment.

Primary outcomes:
measure: Change in Dizziness Handicap Inventory (DHI) Questionnaire Score
timeFrame: 0 and 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Xuan Wu Hosipital
state: Beijing
Study officials:
affiliation: Beijing Xuan Wu Hosipital
name: Jianping Jia, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01600326: A Prospective Comparison of Ultrasound-Guided Percutaneous Platelet-Rich Plasma Injection
Official title: A Prospective Comparison of Ultrasound-Guided Percutaneous Platelet-Rich Plasma Injection Versus Tenotomy for Treatment of Gluteus Minimus and Medius Tendinosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Tendinosis
Tendinitis
Lead sponsor: University of Michigan
Sponsor class: OTHER
First posted: 2012-05-17
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the effectiveness of various treatment soft tendinosis also known as tendinitis.

Detailed description: Currently there are three treatments that are considered standard of care; rest, tenotomy and tenotomy with injections of platelet-rich plasma (PRP). Tenotomy is performed by passing a needle through the abnormal tendon repeatedly until the needle has passed through all areas of the abnormal tendon with softening of the tendon. Tenotomy with PRP injections is performed in the same manner but includes an injection of platelet-rich plasma (PRP) into the tendon. This study will evaluate the effectiveness of tenotomy versus PRP treatment.

Eligibility criteria: Inclusion Criteria:

* Adult subjects with a diagnosis of tendinosis of the hip.
* Adult subjects who have been referred to Dr. Jacobson for the treatment of tendinosis by tenotomy.

Exclusion Criteria:

* pregnancy
* risk of bleeding due to anticoagulant medication
* presence of malignancy
* steroid injection less than 3 months before enrollment

Primary outcomes:
measure: Pain Level and Interference With Activity
timeFrame: Up to 23 days
Secondary outcomes:
measure: Number of Participants Showing Symptomatic Improvement as Assessed in Patient Chart
timeFrame: 15 to 555 days post treatment
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan Hospital
state: Michigan
Study officials:
affiliation: University of Michigan Hospital
name: Jon Jacobson, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05367726: The Contributions of the Multidisciplinary Management of Prosthesis Knee Infections in a Reference Center: A Retrospective Study About 52 Cases.Skin Coverage in a Reference Center: A Retrospective Study About 52 Cases
Official title: The Contributions of the Multidisciplinary Management of TKA Infections in a Reference Center: A Retrospective Study About 52 Cases.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Knee Joint Prosthesis Infection
Flap Necrosis
Skin Graft Complications
Keywords: knee joint prosthesis
Flap
Skin Graft
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2022-05-10
Enrollment: 52
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with a prosthesis knee infection infection whose management requires skin covering plastic surgery

Brief summary: Acute and chronic infection of knee joint prosthesis can have several outcomes, the most feared of which is trans-femoral amputation. In order to save the limb while maintaining function, the management of these infections involves several specialists. Orthopedic surgeons are on the front line for carrying out bacteriological samples as well as for changing the material when necessary. The infectiologists coordinate this care by supervising each of the interventions by an antibiotic therapy adapted to the germs and by ensuring the occurrence of adverse events related to the treatment. Plastic surgeons intervene when the skin cover of the knee is deemed to be precarious or when there is an identified loss of substance that could affect the prognosis of the prosthesis. The main objective of our study is to evaluate the success rate of skin coverage and functional recovery for patients cured of their infection. The secondary objective is the identification of risk factors for skin coverage in this population.


Eligibility criteria: Inclusion Criteria:

* Patients with a prosthesis knee infection whose management requires skin covering plastic surgery
* Surgical procedures performed at the Croix Rousse Hospital

Exclusion Criteria:

* none

Primary outcomes:
measure: rate of patients with prosthesis knee infection requiring skin coverage
timeFrame: 2011-2021
Secondary outcomes:
measure: description of the population at risk of coverage after prosthesis knee infection
timeFrame: 2011-2021
Other outcomes:
Locations:
city: Lyon
country: France
facility: Hospices Civils de Lyon
Study officials:
References:
Clinical trial NCT05930626: Biomarkers of Acrylamide, Glycidol, POPs, PFAS and Disease Outcomes and OMICs Signatures
Official title: Biomarkers of Acrylamide, Glycidol, POPs, PFAS and Disease Outcomes and OMICs Signatures
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Disease
Cardiovascular Diseases
Cancer
Environmental Exposure
Lead sponsor: Karolinska Institutet
Sponsor class: OTHER
Collaborators: name: The Swedish Research Council
First posted: 2023-07-05
Enrollment: 9254
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 60YO: Men and women of 60 years of age living in Stockholm SMC-C: Women living in Uppsala

Brief summary: The aim of the project is to assess the associations between biomarkers of acrylamide and glycidol exposure and disease outcomes in a case-cohort study based on two prospective cohorts with biobanks. The investigators also aim to assess the exposure-affected OMICS signatures and molecular pathways underlying disease development (specifically cardiovascular diseases such as myocardial infarction and stroke and cancer such as breast-, endometrial and colorectal cancer) for these exposures along with persistent organic pollutants (POPs) and per- and polyflouroalkyl substances (PFAS) using a prospective cohort study utilizing and integrating various 'OMICs' technologies.


Eligibility criteria: Inclusion Criteria:

* 60YO: Men and women of 60 years old residing in Stockholm
* SMC-C: Women residing in Uppsala

Exclusion Criteria:

* Subjects will be excluded if they had the outcome under investigation at baseline

Primary outcomes:
measure: Cardiovascular disease
timeFrame: From baseline beginning in 2003 through 2017
measure: Cancer
timeFrame: From baseline (2003 for SMC-C and 1997 for 60YO) until the latest available follow-up, currently 2021
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: