louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00919243: Prednisone for Heart Failure Patients With Hyperuricemia
Official title: Prednisone Versus Allopurinol for Symptomatic Heart Failure Patients With Hyperuricemia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Heart Failure
Hyperuricemia
Keywords: prednisone
allopurinol
heart failure
hyperuricemia
Lead sponsor: Hebei Medical University
Sponsor class: OTHER
First posted: 2009-06-12
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Hyperuricemia is a very common finding in patients with heart failure. It is usually related to diuretic use and deteriorated renal function. The recently evidence showed that uric acid (UA) lowering therapy may improve clinical status in symptomatic heart failure patients with hyperuricemia. In their clinical practice, the investigators found that glucocorticoids could dramatically lower UA while improving renal function. Thus the investigators design this randomized head to head study to test our hypothesis that prednisone have the same efficacy to allopurinol on lowering UA and could improve renal function at the same time.


Eligibility criteria: Inclusion Criteria:

* 18-70 years old
* NYHA Class III-IV
* EF =\< 40%
* Uric acid =\> 9.5 mg/dL

Exclusion Criteria:

* Acute gouty arthritis
* Any condition (other than CHF) that could limit the use of prednisone or allopurinol
* Any concurrent disease likely to limit life expectancy.
* Active myocarditis, or an obstructive or restrictive cardiomyopathy
* Heart Attack, Stroke, Unstable Angina or Cardiac surgery within previous 3 months

Primary outcomes:
measure: Change from baseline in uric acid level
timeFrame: 4 weeks
Secondary outcomes:
measure: Change from baseline in creatinine clearance rate
timeFrame: 4 weeks
measure: Daily urine volume
timeFrame: 4 weeks
measure: Body weight
timeFrame: 4 weeks
measure: patient assessed dyspnea and physician assessed global clinical status
timeFrame: 4 weeks
measure: 6-minute walking distance
timeFrame: 4 weeks
measure: NYHA functional class
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Shijiazhuang
country: China
facility: Kunshen Liu
state: Hebei
Study officials:
References:
citation: Liu C, Zhao Q, Zhen Y, Gao Y, Tian L, Wang L, Ji L, Liu G, Ji Z, Liu K. Prednisone in Uric Acid lowering in Symptomatic Heart Failure Patients With Hyperuricemia (PUSH-PATH) study. Can J Cardiol. 2013 Sep;29(9):1048-54. doi: 10.1016/j.cjca.2012.11.008. Epub 2013 Feb 6.
Clinical trial NCT01252043: Retrospective Review of CT and MR in Pediatric Patients With Cholestasis
Official title: Retrospective Review of Computed Tomography and Magnetic Resonance Images in Pediatric Patients With Cholestasis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cholestasis
Children
Keywords: cholestasis
children
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2010-12-02
Enrollment: 80
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: younger than 18 years of age

Brief summary: The investigators will try to predict the risk of esophageal varices (EVs) in long-term BA survivors using noninvasive computed tomography (CT) or magnetic resonance (MR) indices and the measurement of transverse diameters of paraesophageal and gastroesophageal veins.

Detailed description: We intend to review retrospectively 80 pediatric patients on an average of 2 years, who underwent 64-slice CT or MR examinations between January 2005 and Oct 2010 and had EVs on esophagogastroduodenoscopy. Splenic diameters (mm) and hepatic diameters of all patients were measured. Splenic and hepatic volume indices also calculated. The transverse diameters of paraesophageal varices (PVs) and perigastric varices (PGVs) were measured adjacent to the lower thoracic esophagus and within the lesser sac, respectively.

We will try to find out the possible splenic, hepatic or vascular predicting factors useful to evaluate the risk of clinically evident esophageal varices.

Eligibility criteria: Inclusion Criteria:

* all cholestatic children with CT, MR and complete medical record

Exclusion Criteria:

* all cholestatic children without either CT, MR or complete medical record

Primary outcomes:
measure: esophageal variceal bleeding
timeFrame: retrospective review
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: Department of Medical Imaging, National Taiwan University Hospital
name: Tiffany TF Shih, M.D.
role: STUDY_CHAIR
References:
Clinical trial NCT00202943: Randomized Controlled Trial of TCRFVR and LAUP in Snorers
Official title: Comparison of Clinical Effect Between Temperature-Controlled Radio-Frequency Uvuloplasty and Laser Assisted Uvulo-Pharyngoplasty in Patients Who Snore
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Snorer
Keywords: TCRFVR, LAUP, Snorer
Lead sponsor: Taichung Veterans General Hospital
Sponsor class: OTHER
First posted: 2005-09-20
Enrollment: 40
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: We hypothesis that radiofrequency will cause less post-operative discomfort when compared with laser assited uvulopharyngoplasty. 40 patients with primary snore will be enrolled into this study. After overnight sleep test confimred that no obstructive sleep apnea existed, cases were informed consented. Then they were randomized into two groups. Post-operative pain, duration of analgesics were recorded.

Detailed description: Although Rf group was less effective, they felt less discomfort.

Eligibility criteria: Inclusion Criteria:

* RDI \< 5/h

Exclusion Criteria:

* Previous treated snoring, coagulation disorder

Primary outcomes:
measure: LAUP is more effective in eliminating snoring
Secondary outcomes:
measure: However, Rf cause less post-operative discomfort
Other outcomes:
Locations:
Study officials:
affiliation: Taichung Veterans General Hospital
name: Shih-An Liu, MD, MHA
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05168943: Nylon Versus Polyurethane Epidural Catheters In Patients Undergoing Major Orthopedic Surgery
Official title: Nylon Versus Polyurethane Epidural Catheters In Patients Undergoing Major Orthopedic Surgery
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Epidural; Anesthesia
Catheter Complications
Catheter Blockage
Catheter Dysfunction
Catheter Breakage
Keywords: Epidural Anesthesia
Nylon (Polyamide) Epidural Catheter
Polyurethane Epidural Catheter
Lead sponsor: Damanhour Teaching Hospital
Sponsor class: OTHER_GOV
First posted: 2021-12-23
Enrollment: 60
Sex: ALL
Minimum age (years): 21
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Objectives: To compare the safety and efficacy of nylon (polyamide) epidural catheter versus polyurethane epidural catheter in patients undergoing major orthopedic surgery under continuous epidural anesthesia.

Background: Continuous epidural anesthesia is the most common anesthetic technique used in orthopedic surgery. However, the use of epidural catheters is associated with complications. The insertion of the catheter may be associated with intravascular or intrathecal placement, nerve root irritation, paresthesia, kinking, hematoma, or breakage during catheter removal.

Patients and Methods: This was a prospective, randomized, double-blind clinical trial; carried out on 60 patients undergoing major orthopedic surgery under continuous epidural anesthesia. Patients were randomly allocated into two equal groups; group N, using Nylon catheter, and group P, using Polyurethane catheter.


Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists (ASA) physical status ≤ II
* Age from 21 to 60 years
* Body Mass Index (BMI) \< 35

Exclusion Criteria:

* American Society of Anesthesiologists (ASA) physical status \> II
* Age \< 21 years or \> 60 years
* Body Mass Index (BMI) ≥ 35
* Contraindications to regional anesthesia (including coagulopathy and infection at the injection site)
* Uncooperative patients
* Patients with known allergy to local anesthetics or opioids

Primary outcomes:
measure: Mean and Standard deviation of Time required for epidural catheter insertion (seconds) (mean±SD)
timeFrame: 2 minutes after identifying the epidural space by loss of resistance technique
Secondary outcomes:
measure: Mean and Standard deviation of Time required for epidural catheter to anchor with the catheter connector (seconds) (mean±SD)
timeFrame: 2 minutes after removal of the Tuohy needle through the epidural catheter
measure: Mean and Standard deviation of Time required for epidural catheter removal (seconds) (mean±SD)
timeFrame: 2 minutes after the end of the operation
measure: Number of participants and Rate of Catheter-related complications
timeFrame: 2 minutes after the end of the operation
Other outcomes:
Locations:
city: Damanhūr
country: Egypt
facility: Damanhour Teaching Hospital
state: El-Beheira
Study officials:
affiliation: Damanhour Teaching Hospital
name: Ahmed M Shaat, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04190043: Womens's Experiences of Pregnancy Loss Aftercare in the Gynecological Emergency
Official title: Womens's Experiences of Pregnancy Loss Aftercare in the Gynecological Emergency Department of Montpellier Hospital.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Miscarriage
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2019-12-09
Enrollment: 50
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women with diagnosis of pregnancy loss in the gynecological emergency department of Montpellier Hospital

Brief summary: Introduction: Scientific papers on the womens's experiences of pregnancy loss aftercare in the emergency department show that how announcement is made and how much caregivers show empathy to women, help women to face this difficult moment. However, in most studies, women say they did not have enough information nor support from the medical teams.

Diagnosis of miscarriage in the emergency department is the routine for the caregiver but is often experienced by the woman as the loss of a child.

This study has for goal to bring to light the discrepancy between the caregivers's experience and the women's experience :the given information, the time for consultation, the empathy.

Methods : 2 months after the diagnosis of miscarriage in the emergency room, patients receive a phone call with explanations about the project. If the patient gives her consent, she receives a computer questionnaire by email (questions about : reasons for coming to the emergency room, circumstances of announcement, information given in the emergency room, satisfaction with the care...) In parallel, caregivers have to complete a questionnaire about the same parameters.

The main objective of this study is to evaluate womens's experiences of pregnancy loss aftercare in the emergency department of Montpellier Hospital.

The second objective is to assess the discrepancy between the patient's experience and the caregivers' experience in this situation with the aim of suggesting improvement.


Eligibility criteria: Inclusion criteria :

An individual must fulfill all of the following criteria in order to be eligible for study enrollment:

* Women \> 18 years old
* French speaker
* Diagnosis and management of miscarriage / pregnancy loss in the emergency department
* Miscarriage / pregnancy loss \< 15 SA

Exclusion criteria:

* Subject unable to read or/and write
* Pregnancy loss \> 15 SA.

Primary outcomes:
measure: to evaluate womens's experiences of pregnancy loss aftercare
timeFrame: 1 day
Secondary outcomes:
measure: evaluate the discrepancy between the patient's experience and the caregivers' experience in front of diagnosis of miscarriage.
timeFrame: 1 day
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
affiliation: University Hospital, Montpellier
name: Clara Compan
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06749743: Accuracy Of Detection Of Dental Caries From Intraoral Images Using Different ArtificiaI Intelligence Models
Official title: Accuracy Of Dental Caries Detection From Intraoral Images Using Different Artificial Intelligence Models Versus Conventional Visual Examination Among A Group Of Children: A Diagnostic Accuracy Study
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Dental Caries (Diagnosis)
Artifical Intelligence
Intraoral Images
Keywords: artificial intelligence
dental caries
diagnosis
intraoral images
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-12-27
Enrollment: 398
Sex: ALL
Minimum age (years): 4
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Any child with at least one decayed tooth present at the time of recruitment at the Pediatric dental department diagnostic center, Faculty of Dentistry, Cairo University.

Brief summary: The goal of this observational study is to evaluate the diagnostic accuracy of different deep learning models in detecting dental caries from intra oral images taken by a professional intra oral camera in children. The main question it aims to answer is:

What is the diagnostic accuracy of different deep learning models in detecting dental caries from intra oral images taken by a professional intra oral camera in children compared to the conventional clinical visual examination?


Eligibility criteria: Inclusion Criteria:

* Child dentition having at least one decayed tooth.

Exclusion Criteria:

* Child dentition with developmental enamel defects.
* Children with any systemic medical condition.
* Parent / child refuse to participate in the study.
* Uncooperative child.

Primary outcomes:
measure: Accuracy Of Dental Caries Detection From Intraoral Images Using Different Artificial Intelligence Models Versus Conventional Visual Examination Among A Group Of Children: A Diagnostic Accuracy Study
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Cairo university
Study officials:
References:
Clinical trial NCT04156243: CD19 CARvac T Cells for Patients With Relapsed / Refractory B Cell Malignancies
Official title: Phase I, Interventional, Single Arm, Open Label, Treatment Study to Evaluate the Safety and Tolerability of CD19 CARvac in Patients With Relapsed and/or Refractory B Cell Malignancies
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: EARLY_PHASE1
Conditions: B Cell Lymphoma
B Cell Leukemia
Keywords: CD19
CD19 CAR T cell
Lead sponsor: iCell Gene Therapeutics
Sponsor class: INDUSTRY
Collaborators: name: Peking University Shenzhen Hospital
name: Chengdu Military General Hospital
name: iCAR Bio Therapeutics Ltd.
First posted: 2019-11-07
Enrollment: 20
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a phase I, interventional, single arm, open label, treatment study to evaluate the safety and tolerability of CD19 CARvac in patients with relapsed and/or refractory B cell malignancies.

Detailed description: CD19 CARvac is a chimeric antigen receptor immunotherapy treatment designed to treat

Eligibility criteria: Inclusion Criteria:

1. Diagnosis based on the World Health Organization (WHO) 2008
2. Patients have exhausted standard therapeutic options
3. Systematic usage of immunosuppressive drug or corticosteroid must have been stopped for more than 4 weeks
4. Female must be not pregnant during the study

Exclusion Criteria:

1. Prior solid organ transplantation
2. Potentially curative therapy including chemotherapy or hematopoietic cell transplant
3. Prior treatment with BCMAxCD3 or CS1xCD3 bispecific agents

Primary outcomes:
measure: Number of participants with dose limiting toxicity (DLT) as assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 5.0
timeFrame: 28 days
measure: Type of dose-limiting toxicity (DLT)
timeFrame: 28 days
measure: Number of participants with adverse event by severity as assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 5.0
timeFrame: 2 years
Secondary outcomes:
measure: Overall Response Rate (ORR)
timeFrame: 1 year
measure: Progression-free survival (PFS)
timeFrame: 1 year
measure: Overall survival
timeFrame: 1 year
Other outcomes:
Locations:
city: Chengdu
country: China
facility: The General Hospital of Western Theater Command
city: Shenzhen
country: China
facility: Peking University Shenzhen Hospital
Study officials:
affiliation: Peking University Shenzhen Hospital
name: Hongyu Zhang, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: The General Hospital of Western Theater Command
name: Fang Liu, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Liu F, Sha S, Ma G, Su Y, Xiong Y, He G, Li Y, Hanes WM, Tse W. Treatment of CML-transformed B Cell Acute Lymphoblastic Leukemia (B-ALL) in Adults with Anti-CD19 Chimeric Antigen Receptor T Cell (CAR T) Therapy. Stem Cell Rev Rep. 2020 Dec;16(6):1356-1358. doi: 10.1007/s12015-020-10008-7. No abstract available.
Clinical trial NCT05217043: Language Acquisition in the Brain and Algorithms: Towards Systematic Monitoring of the Evolution of Semantic Representations in Biological and Artificial Neural Networks
Official title: Language Acquisition in the Brain and Algorithms: Towards Systematic Monitoring of the Evolution of Semantic Representations in Biological and Artificial Neural Networks
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Language Acquisition in the Brain
Keywords: Intracranial recordings
Lead sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Sponsor class: NETWORK
First posted: 2022-02-01
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Any patient benefiting from a long-term intracranial brain recording

Brief summary: Speech depends on our ability to recursively combine successive words into a complex sense. Although the order of these putative operations (syntax) has been the subject of extensive examination in the way in which the human brain learns to perform a "Semantic composition" remains largely unknown.

The Rothschild Hospital houses a unit specializing in drug-resistant epilepsy in children from 2 to 20 years old.

The identification of the epileptogenic zone often requires making an iEEG recording for a week (implantation of intracerebral electrodes in depth).

Sometimes this recording has to be repeated, providing a unique opportunity to directly record brain activity at different periods of its development.

Children will listen to pre-recorded phrases and stories such as "The Little Prince of Antoine de Saint-Exupéry" while being recorded with iEEG.


Eligibility criteria: Inclusion Criteria:

* Any patient benefiting from a long-term intracranial brain recording.
* Non-opposition to participating in the study (adult patients)
* Non-opposition of at least one of the holders of the exercise of parental authority (minor patients)

Exclusion Criteria:

* Patient with complete deafness

Primary outcomes:
measure: This is a non-clinical research study investigating from intracranial recordings how speech representation changes throughout human development.
timeFrame: maximum 21 days
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Fondation Ophtalmologique de Rothschild
Study officials:
References:
Clinical trial NCT01448343: Effect of Rapid Transfusion With Fluid Management System 2000® (FMS)
Official title: Effect of Rapid Transfusion With FMS(Fluid Management System 2000®) on the Plasma Potassium Concentration in Adult Liver Transplantation Recipients)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Liver Transplantation
Keywords: transfusion
potassium
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2011-10-07
Enrollment: 10
Sex: ALL
Minimum age (years): 16
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Rapid infusion of red blood cells is known to result in the increase of plasma potassium. The researchers are trying to investigate the change in plasma potassium during rapid infusion of mixed blood components in the reservoir of the fluid management system (FMS) in liver transplant recipients.

Detailed description: FMS is a standard equipment to prepare for the massive bleeding during the liver transplant surgery. This device usually delivers a mixture of red blood cell (RBC), fresh frozen plasma and normal saline. Rapid infusion of RBC is known to result in the increase of potassium and the decrease of calcium in the plasma of the patient. However there is no report about the consequence of rapid transfusion of the blood mixture in the reservoir of the FMS, especially in the liver transplantation recipients. The primary end point of this study is to investigate the change in the plasma potassium and to assess the possibility of hyperkalemia and related morbidity. Changes of blood pH and plasma calcium will also be sought.

Eligibility criteria: Inclusion Criteria:

* liver transplantation recipients

Exclusion Criteria:

* hemoglobin \> 10 g/dL before surgery
* renal failure
* hyperkalemia
* chronic hyponatremia
* cardiac dysfunction

Primary outcomes:
measure: Plasma potassium
timeFrame: Transfusion and sampling of blood are made intraoperatively, mainly during the period of hepatectomy. Overall time of data collection is usually within 4 hrs.
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
References: