Clinical trial NCT06030401: Role Of Transthoracic Ultrasound in Predicting Post-extubation Distress During Successful Weaning
Official title: Role Of Transthoracic Ultrasound in Predicting Post-extubation Distress During Successful Weaning
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Transthoracic US
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-09-11
Enrollment: 51
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: .Any Patient Has Successful Weaning Trial above18Years old in Respiratory ICU

Brief summary: -To Assess Value of Transthoracic Ultrasound In Predicting Post-extubation Distress in Respiratory ICU Using Ultrasound Parameters As Diaphragmatic Excursion ,Diaphragmatic,Diaphragmatic Thickness Fraction,Diaphragmatic Thickness.

Detailed description: Establishing the correct time to extubate mechanically ventilated patients is a crucial issue in the critical care practice. Both premature and delayed extubation prolong the duration of mechanical ventilation and the intensive care unit (ICU) length of stay and increase morbidity and mortality. Therefore, accurate prediction of post-extubation distress and the early diagnosis of the causes responsible for failure of a trial of pressure support ventilation or a trial of totally unsupported respiration are of paramount importance to improve the outcome of mechanically ventilated patients in the ICU.

The Investigators hypothesized that the use of an integrative thoracic ultrasound assessment, encompassing bedside respiratory, and diaphragm sonographic data, could accurately predict post-extubation distress in patients who succeeded in a pressure support ventilation trial. In addition, The Investigators suggest that the use of appropriate analytical methods, that is, machine-learning methods, could permit the evaluation of the specific impact of respiratory and diaphragm sonographic data on the final estimation of a likelihood of post-extubation distress .

Eligibility criteria: Inclusion Criteria:

* Patients above 18 yrs. old who admitted to respiratory ICU and mechanically ventilated due to chest diseases and passed weaning trials

Exclusion Criteria:

* Pregnancy.
* Neuromuscular disorders.
* Psychiatric instability.
* Uncontrolled cardiovascular disease.
* Tracheostomy.
* patints with failed weaning trials.
* Inability to provide informed consent.

Primary outcomes:
measure: post-extubation distress
timeFrame: "through study completion, an average of 3 year".
Secondary outcomes:
measure: Evaluation of different factors that affect weaning outcome as diaphragmatic dysfunction,ventilator associated pneumonia,electrolyte disturbances and so on.
timeFrame: Doing Transthoracic US 48 hour after Starting of Mechanical Ventilation when Patient becomes Weanable during Weaning Trials,and 48 hour Postextubation Weaning and 48 hour postextubation.
Other outcomes:
Locations:
Study officials:
affiliation: Respiratory ICU of Assiut University Hospital
name: Hoda Ahmad Ali, prof
role: STUDY_DIRECTOR
affiliation: Respiratory ICU of Assiut University Hospital
name: Ali Abdelazeem Hassan, prof
role: STUDY_DIRECTOR
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