Clinical trial NCT06386991: Effect of Different Irrigation Solutions on Postoperative Pain and Lesion Healing
Official title: Evaluation of the Effects of Different Irrigation Solutions Used in Regenerative Endodontic Treatment of Lower Molars With Open Necrotic Apexes on Postoperative Pain and Lesion Healing
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE4
Conditions: Endodontic Disease
Lead sponsor: TC Erciyes University
Sponsor class: OTHER
First posted: 2024-04-26
Enrollment: 39
Sex: ALL
Minimum age (years): 8
Maximum age (years): 15
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study researchers plan to conduct, three different irrigation solutions that are responsible for the release of growth factors necessary for the success of regenerative endodontic treatments will be used. These solutions; Ethylene Diamine Tetra Acetic Acid (EDTA), Etidronic Acid and Citric Acid. The aim of this study is to evaluate the effect of different irrigation solutions used in regenerative endodontic treatment of necrotic open apex molar teeth on postoperative pain. Additionally, the healing of these teeth will be monitored for 1 year.

Detailed description: Root canal treatment is a treatment method applied to milk and permanent teeth. The inflamed and necrotic pulp where the root canal is located is cleaned, debrided chemo-mechanically, and finally filled hermetically with a biocompatible material. Necrotic immature teeth lose their restorative and defensive abilities. Since the root canal walls of these teeth are thin and weak, regenerative endodontic procedures are applied more frequently in the treatment of immature teeth to ensure root development and to restore the vitality of the pulp tissue. In this study researchers plan to conduct, three different irrigation solutions that are responsible for the release of growth factors necessary for the success of regenerative endodontic treatments will be used. These solutions; Ethylene Diamine Tetra Acetic Acid (EDTA), Etidronic Acid and Citric Acid. The aim of this study is to evaluate the effect of different irrigation solutions used in regenerative endodontic treatment of necrotic open apex molar teeth on postoperative pain. Additionally, the healing of these teeth will be monitored for 1 year.

Eligibility criteria: Inclusion Criteria:• Molars with open apex

* Teeth with apical periodontitis
* Teeth for which prosthetic restoration is not planned
* Patients between the ages of 8-15 who do not have any significant health problems
* Patients who are not accompanied by periodontal problems and have good oral hygiene

Exclusion Criteria:• People with systemic disease and allergic reactions

* Severely damaged teeth
* If the tooth has previously undergone root canal treatment.
* Use of antibiotics, anti-inflammatory and painkillers in the last two weeks

Primary outcomes:
measure: Determining and recording pain levels on the pain scale between treatment sessions
timeFrame: 2 weeks
Secondary outcomes:
measure: In the follow-up sessions after the treatment, the size of the lesion in the bone (mm2) is measured by radiography.
timeFrame: 2 years
Other outcomes:
Locations:
city: Kayseri
country: Turkey
facility: Erciyes Üniversitesi Diş Hekimliği Fakültesi
Study officials:
affiliation: BAŞ ARAŞTIRMACI
name: ERASLAN AKYÜZ
role: PRINCIPAL_INVESTIGATOR
affiliation: YÜRÜTÜCÜ
name: ÜSTÜN
role: STUDY_DIRECTOR
affiliation: YARDIMCI ARAŞTIRMACI
name: EMİNSOY AVCI
role: STUDY_CHAIR
affiliation: YARDIMCI ARAŞTIRMACI
name: SOLAK KOLÇAKOĞLU
role: STUDY_CHAIR
affiliation: YARDIMCI ARAŞTIRMACI
name: KIZILCI
role: STUDY_CHAIR
References: