Clinical trial NCT03082326: The CCUS Based Characteristic of Hemodynamic and Lung Pathology in Early Stage of Shock in ICU: The Epidemic and Prognostic Value
Official title: The Critical Care Ultrasound Based Characteristic of Hemodynamic and Lung Pathology in Early Stage of Shock in ICU: The Epidemic and Prognostic Value
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Shock
Keywords: shock
critical care ultrasound
hemodynamics
lung pathology
epidemic
prognosis
Lead sponsor: West China Hospital
Sponsor class: OTHER
First posted: 2017-03-17
Enrollment: 181
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Shock patients with 6 hours admitted in ICU in west china hospital of sichuan university.

Brief summary: Shock is a common condition in critical care unit (ICU). It is extremely important that the patient accepts early goal-directed therapy (EGDT) treatment in the early stage of shock. However, several studies failed to demonstrate that the well used variables such as CVP and others could direct to a better treatment. In recent years, critical care ultrasound (CCUS) has been respected as a reliable noninvasive tool and widely used in ICU practice. With CCUS the investigators can accurately acquired the detailed information of the characteristic of the hemodynamics and lung pathology (the systole and diastole function, volume status, valve insufficiency, lung, edema, consolidation, and pleural effusion, etc.). To the investigators knowledge, there is no study investigating the epidemic of such ultrasonic variables and its value to predict to outcome. The aim of this study is to investigate the epidemic and the prognostic value of CCUS Based Characteristic of Hemodynamic and Lung pathology in Early Stage of Shock in patients admitted in ICU.

Detailed description: Adult patients who admitted to the intensive care unit of West China hospital of sichuan university with shock from April 2016 to April 2017 enrolled.

Eligibility criteria: Inclusion Criteria:

1. SBP\<90 mm Hg or MAP \<70 mm Hg or SBP decrease \>40mmHg or need vasoactive drugs;
2. Skin that is cold and clammy, capillary refill time \>4.5s, urine output of \<0.5ml/Kg.hr and lactate\>2mmol/L;
3. SHOCK presented within 6 hr.

Exclusion Criteria:

1. \<18 years old;
2. Pregnancy;
3. Patient or family member refuse to be enrolled.

Primary outcomes:
measure: all cause mortality
timeFrame: 28 days
Secondary outcomes:
measure: length of mechanical ventilation
timeFrame: through study completion, an average of 28 days
measure: ICU length of stay
timeFrame: through study completion, an average of 28 days
measure: hospital length of stay
timeFrame: through study completion, an average of 28 days
Other outcomes:
Locations:
city: Chengde
country: China
facility: West China Hospital,Sichuan University
state: Sichuan
Study officials:
affiliation: West China Hospital
name: yan kang, doctor
role: STUDY_CHAIR
References:
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citation: Zhou R, Zou T, Yin W, Wang X, Kang Y; Chinese Critical Ultrasound Study Group (CCUSG). Functional mitral regurgitation combined with increased early diastolic transmitral velocity to early mitral annulus diastolic velocity ratio is associated with a poor prognosis in patients with shock. Chin Med J (Engl). 2021 Sep 15;134(19):2299-2305. doi: 10.1097/CM9.0000000000001756.
citation: Zou T, Yin W, Li Y, Deng L, Zhou R, Wang X, Chao Y, Zhang L, Kang Y; Chinese Critical Ultrasound Study Group (CCUSG). Hemodynamics in Shock Patients Assessed by Critical Care Ultrasound and Its Relationship to Outcome: A Prospective Study. Biomed Res Int. 2020 Sep 15;2020:5175393. doi: 10.1155/2020/5175393. eCollection 2020.