Clinical trial NCT03853174: Exercise Training and Inflammatory Mediators in COPD
Official title: Effect of Exercise Training on Inflammatory Mediators in COPD
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COPD
Keywords: COPD
Inflammation
exercise training
Lead sponsor: Faculty of Medicine, Sousse
Sponsor class: OTHER
First posted: 2019-02-25
Enrollment: 28
Sex: MALE
Minimum age (years): 40
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020\[1\]. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable\[2\].

Detailed description: Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable.Not only the long-term exposition to noxious particles and gases contributes to the development of COPD, but also so many others factors such as genetics and cigarette smoking. It has been shown that cigarettes are harmful and contributed to different extra pulmonary disorders. Indeed, it induced a systemic inflammation that was considered as a key process in the pathogenesis of COPD and triggered the activation of inflammatory cells and an abnormal increase of circulating cytokines such as CRP, interleukin (IL6), IL8, tumor necrosis factor alpha (TNF alpha) and leptin.

Eligibility criteria: Inclusion Criteria:

* COPD diagnosed by pulmonary function testing
* Clinically stable
* Abscence of other obstructive diseases
* Signed written consent

Exclusion Criteria:

* Neuromuscular diseases -Severe psychiatric, neurologic or musculoskeletal conditions and /or instable--- --
* cardiovascular diseases.
* Contre-indications to physical therapy
* Acute exacerbations a month before the intervention

Primary outcomes:
measure: Enzyme linked immunosorbent assay for serum cytokines levels change
timeFrame: Baseline, 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Sousse
country: Tunisia
facility: Amal Acheche
Study officials:
affiliation: Faculty of Medicine of Sousse Sousse, Tunisia
name: Amal Acheche, Phd
role: PRINCIPAL_INVESTIGATOR
References:
citation: authors non mentionned., global initiative for chronic lung disease. 2017
citation: Molfino NA, Jeffery PK. Chronic obstructive pulmonary disease: histopathology, inflammation and potential therapies. Pulm Pharmacol Ther. 2007;20(5):462-72. doi: 10.1016/j.pupt.2006.04.003. Epub 2006 May 6.
citation: Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016 Jul;138(1):16-27. doi: 10.1016/j.jaci.2016.05.011. Epub 2016 May 27.
citation: Barnes PJ. Cellular and molecular mechanisms of chronic obstructive pulmonary disease. Clin Chest Med. 2014 Mar;35(1):71-86. doi: 10.1016/j.ccm.2013.10.004. Epub 2013 Dec 12.