louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06169930: Development and Validation of a Survival Prediction Model for Esophageal Cancer Patients After Esophagectomy
Official title: Development and Validation of A Overall Survival Prediction Model for Esophageal Squamous Cell Carcinoma: A Novel pN Classification
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Survivorship
Keywords: survival
esophgeal cancer
Lead sponsor: Sichuan Cancer Hospital and Research Institute
Sponsor class: OTHER
First posted: 2023-12-14
Enrollment: 2957
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients from the Sichuan Cancer Hospital \& Institute Esophageal Cancer Case Management Database (SCH-ECCM Database) from January 2010 to December 2017.

Brief summary: In this retrospective study, we analyzed data from the Sichuan Cancer Hospital \& Institute Esophageal Cancer Case Management Database (SCH-ECCM Database) from January 2010 to December 2017. Our study focused on examining the clinicopathological characteristics, lymph node removal at each station, and treatment details of patients with esophageal squamous cell carcinoma (ESCC) who underwent esophagectomy. Using this data, we developed a prediction model for OS by considering a combination of clinical characteristics and details of lymphadenectomy variables.

Detailed description: In this retrospective study, we analyzed data from the Sichuan Cancer Hospital \& Institute Esophageal Cancer Case Management Database (SCH-ECCM Database) from January 2010 to December 2017. Our study focused on examining the clinicopathological characteristics, lymph node removal at each station, and treatment details of patients with esophageal squamous cell carcinoma (ESCC) who underwent esophagectomy. Using this data, we developed a prediction model for OS by considering a combination of clinical characteristics and details of lymphadenectomy variables. Additionally, the receiver operating characteristic curve demonstrated an area under the curve greater than 0.7 at 1, 3, and 5 years in both the verification and training groups. Furthermore, Kaplan-Meier (K-M) curves showed that our model effectively distinguished between high- and low-risk groups (p \< 0.01).

Eligibility criteria: Inclusion criteria:

* Patients underwent esophagectomy at our hospital.

Exclusion criteria:

* pathology confirmed a non-squamous cell carcinoma,
* the tumor was located outside of the thoracic region,
* R1/R2 resection was performed indicating incomplete tumor removal,
* evidence of distant tumor metastasis was observed, or
* they underwent preoperative neoadjuvant therapy

Primary outcomes:
measure: Survival
timeFrame: April 2022-April 2024
Secondary outcomes:
Other outcomes:
Locations:
city: Chengdu
country: China
facility: Sichuan Cancer Hospital and Research Institute
state: Sichuan
Study officials:
References:
Clinical trial NCT06622330: The Effect of Position Change on Pain and Cerebral Oxygen Saturation
Official title: The Effect of Position Change on Pain and Cerebral Oxygen Saturation After Endotracheal Aspiration
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Children
Keywords: Pediatrics
position
pain
oxygen saturation
Lead sponsor: Istanbul Medipol University Hospital
Sponsor class: OTHER
First posted: 2024-10-02
Enrollment: 70
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized controlled trial
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study is a randomized controlled experimental study to investigate the effect of position change on pain and cerebral oxygen saturation after endotracheal aspiration in pediatric patients.

Detailed description: This study is a randomized controlled experimental study to investigate the effect of position change on pain and cerebral oxygen saturation after endotracheal aspiration in pediatric patients. The study sample consisted of 70 pediatric patients (35 in the control group and 35 in the intervention group) who met the inclusion criteria and whose parents gave informed consent. The research data were collected using the "Child Identification Form" and the "Behavioral Pain Scale". SPSS 24 program was used to analyze the data obtained in the study. Children in the experimental group were given 30 minutes of wrapping and 30 minutes of fetal position after aspiration. Children in the control group did not receive any treatment.

Eligibility criteria: Inclusion Criteria:

* Pediatric patients whose consent form is signed by their legal guardian
* Intubated pediatric patients receiving mechanical ventilation support
* Non-sedatized pediatric patients
* Pediatric patients who have received only paracetamol and whose duration of action has exceeded 4-6 hours

Exclusion Criteria:

* Unconscious pediatric patients
* Pediatric patients receiving pharmacologic drugs other than paracetamol
* Unstable pediatric patients
* Pediatric patients with painful procedures during the procedure

Primary outcomes:
measure: Behavioral Pain Scale
timeFrame: Measured before aspiration, 1 and 2 hours after aspiration. Each measurement lasted 10 minutes.
measure: Cerebral oxygen saturation
timeFrame: Measured before aspiration, 1 and 2 hours after aspiration. Each measurement lasted 10 minutes.
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul Medipol University
state: Beykoz
Study officials:
affiliation: 444 85 44
name: Aysel Kökcü Doğan
role: STUDY_DIRECTOR
affiliation: Istanbul Medipol UniversityInstitute of Health Sciences
name: Aysel Kökcü Doğan
role: STUDY_DIRECTOR
References:
Clinical trial NCT04720430: Blood Sample Collection for Experimental Blood Test to Track Liver Cancer
Official title: Circulating MicroRNA Levels as a Predictor of Successful Bridging or Down-Staging Loco-Regional Therapy (LRT) to Liver Transplantation for Patients With Hepatocellular Carcinoma (HCC)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hepatocellular Carcinoma
Lead sponsor: Thomas Jefferson University
Sponsor class: OTHER
First posted: 2021-01-22
Enrollment: 7
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patientss with hepatocellular carcinoma felt to be reasonable candidate for liver transplantation, potentially contingent on success of down-staging therapy

Brief summary: This study investigates if an experimental blood test can help predict how well cancer will remain under control with treatment. Ther experimental blood test involves measuring mircoRNAs. MicroRNAs are small molecules which help regulate how genes are expressed. This information may help researchers guide treatment for other patients in the future.


Eligibility criteria: Inclusion Criteria:

* Provide signed and dated informed consent form
* Willing to comply with all study procedures and be available for the duration of the study
* Definite diagnosis of hepatocellular carcinoma established (by standard radiographic or histologic criteria)
* Felt to be reasonable candidate for liver transplantation, potentially contingent on success of down-staging therapy

Exclusion Criteria:

* Either active or recent solid organ cancer other than hepatocellur carcinoma (HCC) within the last 5 years, unless determined by transplant hepatology team not to represent contra-indication to liver transplantation
* Contra-indication to LRT (as assessed by interventional radiologist, for example severe thrombocytopenia, severe vascular disease precluding access, etc)
* History of prior liver transplantation
* Active or prior systemic therapy for HCC

Primary outcomes:
measure: Patient Clinical Status - Liver Transplant
timeFrame: At study completion, up to 12 months
measure: Patient Clinical Status - Death
timeFrame: At study completion, up to 12 months
measure: Patient Clinical Status - Candidacy
timeFrame: At study completion, up to 12 months
measure: Patient Clinical Status
timeFrame: At study completion, up to 12 months
measure: Incidence of "Wait List Drop Off"
timeFrame: At study completion, up to 12 months
Secondary outcomes:
measure: Time to "Wait List Drop Off"
timeFrame: Up to 12 months
measure: Clinical Status of the subset of patients successfully reaching liver transplant
timeFrame: At 1 year after transplantation
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Thomas Jefferson University Hospital
state: Pennsylvania
Study officials:
References:
Clinical trial NCT03823430: Pupillometry : Predictive Indicator in External Ventricular Drain Clamping ?
Official title: Pupillometry : Predictive Indicator in External Ventricular Drain Clamping ?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Brain Damage
External Ventricular Drain
Hydrocephalus
Lead sponsor: Association Pro-arte
Sponsor class: OTHER
First posted: 2019-01-30
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Any patient with an external ventricular drain in neurologic ICU can be recruited in the study if all the eligibility criteria are met.

Brief summary: Pupillar diameter variation to predict success or failure of external ventricular derivation clamping.

Pupillometry utilisation as a diagnostic tool in external ventricular clamping test in neurological ICU should improve patients care in several ways :

* earlier use of ventriculo-peritoneal or ventriculo-atrial shunts to shorten the external ventricular treatment duration and thus reduce risks of infection and hospital stay duration
* limit the medical imagery prescription and radiation exposition
* avoid neurological deterioration linked to the external ventricular drain clamping in case of the pupillometric parameters variation would be earlier than clinical signs


Eligibility criteria: Inclusion Criteria:

* Neurologic ICU hospitalization
* Traumatic brain injury
* External ventricular drain

Exclusion Criteria:

* Legal protection
* refusal
* therapeutics limitation
* craniectomy
* pupillar anomaly

Primary outcomes:
measure: Pupillar diameter variation to predict success or failure of external ventricular clamping
timeFrame: 24 hours after clamping
Secondary outcomes:
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU Clermont Ferrand
city: Grenoble
country: France
facility: Chu Grenoble Alpes
Study officials:
References:
Clinical trial NCT02507830: Mesh Fixation With a Synthetic Glue in Primary Inguinal Hernia Repair
Official title: Mesh Fixation With a Synthetic Glue in Primary Inguinal Hernia Repair
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Inguinal Hernia
Lead sponsor: Rambam Health Care Campus
Sponsor class: OTHER
First posted: 2015-07-24
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: adults older than 18 undergoing a primary inguinal hernia repair

Brief summary: Prospective observational study with mesh fixation using FDA approved synthetic glue,glubran 2 and standard mesh fixation with stiches in primary inguinal hernia repair surgery. The investigators aim is to recruit 150 patients for the study.

The outcomes The investigators would like to determine are : postoperative pain,recurrences and complication rates such as seromas.

Detailed description: Prospective observational study with mesh fixation using FDA approved synthetic glue,glubran 2 and standard mesh fixation with stiches in primary inguinal hernia repair surgery. The investigators aim is to recruit 150 patients for the study.

The outcomes The investigators would like to determine are : postoperative pain,recurrences and complication rates such as seromas.

Eligibility criteria: Inclusion Criteria:

* Primary Inguinal hernia

Exclusion Criteria:

* Recurrent hernia
* Large inguinoscrotal hernias
* Bilateral inguinal hernias

Primary outcomes:
measure: Postoperative pain (Evaluation will be conducted through scale and a questionnaire )
timeFrame: 2 years
Secondary outcomes:
measure: Hernia recurrence (Evaluation will be conducted through a questionnaire and physical examination )
timeFrame: 2 years
measure: Postoperative complications (Evaluation will be conducted through a questionnaire and physical examination )
timeFrame: 2 years
Other outcomes:
Locations:
city: Haifa
country: Israel
facility: Rambam Health Care Campus
Study officials:
affiliation: Rambam Health Care Campus
name: Adel Abu_Salih, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01337830: Pilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen in Reducing Cigarette Craving in Smokers
Official title: A Randomized, Double-Blind, Crossover, Pilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen, a Smoking Aversive Lozenge, in Reducing Craving for a Cigarette in Daily Smokers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Tobacco Use Disorder
Smoking
Keywords: smoking
smokeless
aversion
nicotine
nicotine replacement
Lead sponsor: Star Scientific, Inc
Sponsor class: INDUSTRY
First posted: 2011-04-19
Enrollment: 111
Sex: ALL
Minimum age (years): 23
Maximum age (years): 72
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: Study to determine the safety and effectiveness of Ariva® Silver Wintergreen lozenge on reducing craving for a cigarette in daily smokers.

Detailed description: Each subject will be given an Ariva® Silver Wintergreen lozenge or a Silver Wintergreen lozenge, which contains only silver salt, on a random basis.

Once the lozenge has dissolved in the mouth, subjects will smoke one of their own cigarettes, and will answer questions about the experience and their craving for a cigarette.

After a washout period, each subject will repeat the steps with the second type of lozenge.

Eligibility criteria: Inclusion Criteria:

* healthy adult smoker
* smoking for at least 5 years
* smoking at least one (1) pack of cigarettes a day
* interest in quitting smoking

Exclusion Criteria:

* known allergy to silver or silver salts
* pregnant or breast-feeding
* current drug or alcohol abuse, and/or history of drug or alcohol dependence within 3 months of study

Primary outcomes:
measure: Effectiveness of Ariva® Silver Wintergreen lozenge on reducing craving for a cigarette in daily smokers
timeFrame: 90 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Martinsburg
country: United States
facility: Comfort Inn
state: West Virginia
Study officials:
affiliation: Star Scientific, Inc
name: Maria Varga, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03790930: Deep-learning Based Classification of Spine CT
Official title: Deep-learning Based Classification of Spine CT
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Surgical Procedure, Unspecified
Lead sponsor: Shanghai 10th People's Hospital
Sponsor class: OTHER
Collaborators: name: Third Affiliated Hospital, Sun Yat-Sen University
First posted: 2019-01-02
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with thin layer spinal CT covering targeted level will be included.

Brief summary: It is time-consuming for spine surgeons or radiologists to conduct manual classifications of spinal CT, which may also be correlated with high inter-observer variance. With the development of computer science, deep learning has emerged as a promising technique to classify images from individual level to pixel level. The main of the study is to automatically identify and classify the lesions, or segment targeted structures on spinal CT with deep learning.

Detailed description: Computer tomography (CT) is one of the most important imaging tool to assist the diagnostic and treatment of spinal disease. Classification of specific targets (e.g. individuals, lesions, etc.) is one of the most common mission of medical image analysis. However, it is time-consuming for spine surgeons or radiologists to conduct manual classifications of spinal CT, which may also be correlated with high inter-observer variance. With the development of computer science, deep learning has emerged as a promising technique to classify images from individual level to pixel level. The main of the study is to automatically identify and classify the lesions, or segment targeted structures on spinal CT with deep learning.

Eligibility criteria: Inclusion Criteria:

- spinal thin layer CT

Exclusion Critera:

* medals or other implants induce artifact
* poor image quality

Primary outcomes:
measure: classification accuracy
timeFrame: 1 day
measure: segmentation accuracy
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai Tenth People's Hospital
state: Shanghai
Study officials:
affiliation: Shanghai 10th People's Hospital
name: Shisheng He, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04037930: Cardiovascular Response in Implant Surgery
Official title: Changes in Cardiovascular Response and Dental Anxiety in Multiple Implant Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Dental Anxiety
Cardiovascular Abnormalities
Lead sponsor: Erzincan University
Sponsor class: OTHER
First posted: 2019-07-30
Enrollment: 100
Sex: ALL
Minimum age (years): 30
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 100 patients over the age of 30 undergoing elective dental implant surgery

Brief summary: The aim of this study was to observe the level of anxiety and its relationship with cardiovascular changes in each implant.


Eligibility criteria: Inclusion Criteria:

* Over 30
* 4 years and older implant in the same session

Exclusion Criteria:

* patients with syndrome,
* having systemic disease,
* having heart problems,
* undergo another oral or maxillofacial procedure in the last 6 months,
* using medications that may cause changes in medical conditions and heart rate,

Primary outcomes:
measure: Heart rate
timeFrame: 4 months
Secondary outcomes:
Other outcomes:
Locations:
city: Erzincan
country: Turkey
facility: Erzincan University
Study officials:
affiliation: Erzincan University
name: ilke kupeli
role: PRINCIPAL_INVESTIGATOR
References:
citation: Corah NL. Development of a dental anxiety scale. J Dent Res. 1969 Jul-Aug;48(4):596. doi: 10.1177/00220345690480041801. No abstract available.
citation: CANDIDO, Milene Cardoso, et al. Clinical setting influences physiological responses in dental implant patients. Brazilian Journal of Oral Sciences, 2014, 13.2: 109-113.
citation: Newton JT, Buck DJ. Anxiety and pain measures in dentistry: a guide to their quality and application. J Am Dent Assoc. 2000 Oct;131(10):1449-57. doi: 10.14219/jada.archive.2000.0056.
citation: Nagao H, Munakata M, Tachikawa N, Shiota M, Kasugai S. [Clinical study of risk management for dental implant treatment--changes of blood pressure and pulse rate during implant surgery under local anesthesia]. Kokubyo Gakkai Zasshi. 2002 Mar;69(1):27-33. doi: 10.5357/koubyou.69.27. Japanese.
Clinical trial NCT01467830: Open Inguinal Hernia Repair With Mesh,the Use of Absorbable Versus Non Absorbable Fixation Sutures
Official title: Open Inguinal Hernia Repair With Mesh,the Use of Absorbable Versus Non Absorbable Fixation Sutures
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Inguinal Hernia
Keywords: absorbable sutures efficacy
reducing Adverse effect to be caused from surgery
Inguinal Hernia repair with mesh
Lead sponsor: Rambam Health Care Campus
Sponsor class: OTHER
First posted: 2011-11-09
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the efficacy of mesh fixation using absorbable versus non-absorbable sutures.


Eligibility criteria: Inclusion Criteria:

* all patients undergoing initial unilateral Open Inguinal Hernia Repair surgery.

Exclusion Criteria:

* patients having repeated Inguinal Hernia or bilateral Hernia
* patients undergoing laparoscopic surgery.

Primary outcomes:
measure: Impact of absorbable sutures in inguinal hernia repair on hernia recurrence and post operative outcome
timeFrame: two years
Secondary outcomes:
Other outcomes:
Locations:
city: Haifa
country: Israel
facility: Rambam Health Care Campus
Study officials:
affiliation: Rambam Health Care Campus
name: Adel Abu_salih, M.D
role: PRINCIPAL_INVESTIGATOR
References: