Clinical trial NCT05704738: A Study to Evaluate Rocatinlimab (AMG 451) in Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)
Official title: A Phase 3, Randomized, 52-week, Placebo-controlled, Double-blind Study With Re-randomization to Assess the Efficacy, Safety, and Tolerability of Rocatinlimab (AMG 451) in Adolescent Subjects With Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-ASTRO)
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Atopic Dermatitis
Keywords: Atopic Dermatitis
AMG 451
KHK4083
Rocatinlimab
Lead sponsor: Amgen
Sponsor class: INDUSTRY
First posted: 2023-01-30
Enrollment: 532
Sex: ALL
Minimum age (years): 12
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy and safety of rocatinlimab in monotherapy and combination therapy treatment in adolescent participants.


Eligibility criteria: Inclusion Criteria:

* Age ≥ 12 to \< 18 years at Day 1.
* Diagnosis of AD (according to American Academy of Dermatology Consensus Criteria \[Eichenfield et al, 2014\]) that has been present for at least 12 months before signing of informed consent.
* Body weight ≥ 40 kg at screening.
* History of inadequate response to TCS of medium to higher potency (with or without TCI).
* EASI score ≥ 12 at initial screening.
* EASI score ≥ 16 at Day 1.
* vIGA-AD score ≥ 3.
* ≥10% body surface area of AD involvement.
* Worst pruritus NRS ≥ 4.

Exclusion Criteria:

* Treatment with a biological product within 12 weeks or 5 half-lives, whichever is longer, prior to Day 1.
* Treatment with any of the following medications or therapies within 4 weeks or 5 half-lives, whichever is longer, prior to Day 1:

  1. Systemic corticosteroids
  2. Non-biologic, non-targeted systemic immunosuppressants
  3. Phototherapy
  4. Oral or Topical Janus kinase inhibitors
* Treatment with any of the following medications or therapies within 1 week, prior to Day 1:

  1. TCS of any potency
  2. TCI
  3. Topical phosphodiesterase 4 inhibitors
  4. Other topical immunosuppressive agents

Primary outcomes:
measure: Achievement of a Validated Investigator's Global Assessment for Atopic Dermatitis Score of 0 (Clear) or 1 (Almost Clear) with a ≥ 2 Point Reduction From Baseline (vIGA-AD 0/1) at Week 24
timeFrame: Baseline and Week 24
measure: Achievement of ≥ 75% Reduction From Baseline in EASI Score (EASI 75) at Week 24
timeFrame: Baseline and Week 24
Secondary outcomes:
measure: Achievement of EASI 75 at Week 16
timeFrame: Baseline and Week 16
measure: Achievement of a vIGA-AD 0/1 at Week 16
timeFrame: Baseline and Week 16
measure: Achievement of a ≥ 4-point Reduction From Baseline in Weekly Average of Daily Worst Pruritus Numeric Rating Scale (NRS) Score at Week 16 in Participants with Baseline Weekly Average of Daily Worst Pruritus NRS Score ≥ 4
timeFrame: Baseline and Week 16
measure: Achievement of a ≥ 4-point Reduction From Baseline in Weekly Average of Daily Worst Pruritus NRS Score at Week 24 in Participants with Baseline Weekly Average of Daily Worst Pruritus NRS Score ≥ 4
timeFrame: Baseline and Week 24
measure: Achievement of ≥ 90% Reduction From Baseline in EASI Score (EASI 90) at Week 24
timeFrame: Baseline and Week 24
measure: Achievement of a ≥ 4-point Reduction From Baseline in Weekly Average of AD Skin Pain NRS Score at Week 24 in Participants with Baseline Weekly Average of AD Skin Pain NRS Score ≥ 4
timeFrame: Baseline and Week 24
measure: Achievement of a vIGA-AD Score of 1 with Presence of Only Barely Perceptible Erythema or vIGA-AD Score of 0 (revised Investigator's Global Assessment [rIGA™] 0/1) at Week 24
timeFrame: Baseline and Week 24
measure: Initiation of rescue therapy for AD at or before Week 16
timeFrame: Baseline to Week 16
measure: Initiation of rescue therapy for AD at or before Week 24
timeFrame: Baseline to Week 24
measure: Change From Baseline in Weekly Average of Daily Worst Pruritus NRS Score at Week 16
timeFrame: Baseline to Week 16
measure: Change From Baseline in Weekly Average of Daily Worst Pruritus NRS Score at Week 24
timeFrame: Baseline to Week 24
measure: Change From Baseline in Scoring of Atopic Dermatitis (SCORAD) Itch Visual Analog Scale (VAS) Score at Week 16
timeFrame: Baseline to Week 16
measure: Change From Baseline in SCORAD Itch VAS Score at Week 24
timeFrame: Baseline to Week 24
measure: Achievement of a ≥ 4-point Reduction from Baseline in Dermatology Life Quality Index (DLQI) Score at Week 24 in Participants with Baseline DLQI ≥ 4 in Participants ≥ 16 Years of Age at Enrollment
timeFrame: Baseline and Week 24
measure: Change From Baseline in DLQI Score at Week 24 in Participants ≥ 16 Years of Age at Enrollment
timeFrame: Baseline to Week 24
measure: Change From Baseline in CDLQI Score at Week 24 in Participants < 16 Years of Age at Enrollment
timeFrame: Baseline to Week 24
measure: Achievement of a ≥ 4-point Reduction From Baseline in Patient Oriented Eczema Measure (POEM) Score at Week 24 in Participants with Baseline POEM Score ≥ 4
timeFrame: Baseline and Week 24
measure: Change From Baseline in POEM Score at Week 24
timeFrame: Baseline to Week 24
measure: Achievement of a ≥ 4-point Reduction From Baseline in Weekly Average of Daily AD Skin Pain NRS Score at Week 16 in Participants with Baseline Weekly Average of Daily AD Skin Pain NRS Score ≥ 4
timeFrame: Baseline and Week 16
measure: Change From Baseline in Weekly Average of Daily AD Skin Pain NRS Score at Week 24
timeFrame: Baseline and Week 24
measure: Change From Baseline in Weekly Average of Daily AD Skin Pain NRS Score at Week 16
timeFrame: Baseline and Week 16
measure: Achievement of a ≥ 3-point Reduction From Baseline in Weekly Average of Daily AD Skin Pain NRS Score at Week 24 in Participants with Baseline Weekly Average of Daily AD Skin Pain NRS Score ≥ 3
timeFrame: Baseline and Week 24
measure: Achievement of a ≥ 3-point Reduction From Baseline in Weekly Average of Daily AD Skin Pain NRS Score at Week 16 in Participants with Baseline Weekly Average of Daily AD Skin Pain NRS Score ≥ 3
timeFrame: Baseline and Week 16
measure: Change From Baseline in Weekly Average of Sleep Disturbance NRS Score at Week 24
timeFrame: Baseline to Week 24
measure: Achievement of a Hospital Anxiety and Depression Scale (HADS)-anxiety Subscale Score < 8 at Week 24 in Participants with Baseline HADS-anxiety Subscale Score ≥ 8
timeFrame: Baseline and Week 24
measure: Change From Baseline in HADS-anxiety Subscale Score at Week 24
timeFrame: Baseline to Week 24
measure: Achievement of a HADS-depression Subscale Score < 8 at Week 24 in Participants with Baseline HADS-depression Subscale Score ≥ 8
timeFrame: Baseline and Week 24
measure: Change From Baseline in HADS-depression Subscale Score at Week 24
timeFrame: Baseline to Week 24
measure: Achievement of a ≥ 8.7-point Reduction from Baseline in Severity SCORAD Score at Week 24 in Participants with Baseline SCORAD Score ≥ 8.7
timeFrame: Baseline and Week 24
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Cahaba Dermatology and Skin Health Center
state: Alabama
city: Cullman
country: United States
facility: AllerVie Clinical Research- Cullman
state: Alabama
city: Tucson
country: United States
facility: Eclipse Clinical Research
state: Arizona
city: North Little Rock
country: United States
facility: Arkansas Research Trials, LLC
state: Arkansas
city: Fremont
country: United States
facility: Center for Dermatology Clinical Research Inc
state: California
city: Fullerton
country: United States
facility: Doc1 Healthcare Systems Incorporated
state: California
city: Inglewood
country: United States
facility: Axon Clinical Research
state: California
city: Laguna Niguel
country: United States
facility: Avance Clinical Trials
state: California
city: Palmdale
country: United States
facility: Cura Clinical Research
state: California
city: Sacramento
country: United States
facility: Integrative Skin Science and Research
state: California
city: Sacramento
country: United States
facility: University of California at Davis Medical Center
state: California
city: San Diego
country: United States
facility: Allergy and Asthma Medical Group and Research Center
state: California
city: San Diego
country: United States
facility: University of California at San Diego Rady Childrens Hospital San Diego
state: California
city: Santa Monica
country: United States
facility: Clinical Science Institute
state: California
city: Sherman Oaks
country: United States
facility: Cura Clinical Research Sherman Oaks
state: California
city: Denver
country: United States
facility: Velocity Clinical Research - Denver
state: Colorado
city: Washington
country: United States
facility: Childrens National Medical Center
state: District of Columbia
city: Brandon
country: United States
facility: Clinical Research of Brandon
state: Florida
city: Clearwater
country: United States
facility: Academic Alliance in Dermatology - Saint Petersburg Office
state: Florida
city: Coral Springs
country: United States
facility: Corazon United States of America, LLC doing business as Life Clinical Trials
state: Florida
city: Delray Beach
country: United States
facility: Palm Beach Dermatology Group
state: Florida
city: Hialeah
country: United States
facility: Direct Helpers Research Center
state: Florida
city: Margate
country: United States
facility: Glick Skin Institute
state: Florida
city: Miami Lakes
country: United States
facility: Deluxe Health Care LLC
state: Florida
city: Miami Lakes
country: United States
facility: Savin Medical Group LLC
state: Florida
city: Miami Lakes
country: United States
facility: Angels Clinical Research Institute
state: Florida
city: Miami
country: United States
facility: Miami Clinical Research
state: Florida
city: Miami
country: United States
facility: ara Professionals Limited Liability Corporation
state: Florida
city: Orange City
country: United States
facility: Optimal Research Sites, LLC
state: Florida
city: Orlando
country: United States
facility: Clinical Associates of Orlando Limited Liability Company
state: Florida
city: Orlando
country: United States
facility: Clinical Research Investments
state: Florida
city: Tampa
country: United States
facility: University of South Florida
state: Florida
city: Columbus
country: United States
facility: Centricity Research Columbus
state: Georgia
city: Sandy Springs
country: United States
facility: Advanced Medical Research PC
state: Georgia
city: Savannah
country: United States
facility: Divine Dermatology and Aesthetics
state: Georgia
city: Thomasville
country: United States
facility: McIntosh Clinic PC
state: Georgia
city: Boise
country: United States
facility: Treasure Valley Medical Research
state: Idaho
city: Meridian
country: United States
facility: Velocity Clinical Research - Boise
state: Idaho
city: Skokie
country: United States
facility: NorthShore University HealthSystem Clinical Trials Center
state: Illinois
city: Indianapolis
country: United States
facility: Dawes Fretzin Clinical Research Group, LLC
state: Indiana
city: New Albany
country: United States
facility: Southern Indiana Clinical Trials
state: Indiana
city: Plainfield
country: United States
facility: The Indiana Clinical Trials Center PC
state: Indiana
city: Bowling Green
country: United States
facility: Equity Medical
state: Kentucky
city: Murray
country: United States
facility: Kentucky Advanced Medical Research LLC
state: Kentucky
city: Monroe
country: United States
facility: Industrial Medicine Associates Clinical Research Advanced Dermatology Care
state: Louisiana
city: Rockville
country: United States
facility: Aesthetic and Dermatology Center
state: Maryland
city: Rockville
country: United States
facility: Derm Associates, PC
state: Maryland
city: Auburn Hills
country: United States
facility: Oakland Hills Dermatology
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Health System
state: Michigan
city: Flint
country: United States
facility: Onyx Clinical Research
state: Michigan
city: Saint Joseph
country: United States
facility: MediSearch Clinical Trials
state: Missouri
city: Saint Louis
country: United States
facility: Saint Louis University
state: Missouri
city: Lincoln
country: United States
facility: Somnos Clinical Research
state: Nebraska
city: Reno
country: United States
facility: Skin Cancer and Dermatology Institute
state: Nevada
city: Portsmouth
country: United States
facility: Allcutis Research
state: New Hampshire
city: Bridgewater
country: United States
facility: The Dermatology Center of New Jersey
state: New Jersey
city: Albuquerque
country: United States
facility: University of New Mexico
state: New Mexico
city: Bronx
country: United States
facility: Yeshiva University - Montefiore Medical Center
state: New York
city: Brooklyn
country: United States
facility: Ace Clinical Trials
state: New York
city: East Syracuse
country: United States
facility: Empire Dermatology
state: New York
city: Jackson Heights
country: United States
facility: Smart Medical Research Inc
state: New York
city: Kew Gardens
country: United States
facility: Forest Hills Dermatology Group
state: New York
city: New York
country: United States
facility: Pioneer Clinical Research New York
state: New York
city: New York
country: United States
facility: Cornell University - Weill Cornell Medicine
state: New York
city: Rochester
country: United States
facility: Rochester Clinical Research
state: New York
city: Durham
country: United States
facility: Duke South Durham
state: North Carolina
city: Boardman
country: United States
facility: Optima Research
state: Ohio
city: Mayfield Heights
country: United States
facility: Apex Clinical Research Center LLC
state: Ohio
city: Chickasha
country: United States
facility: Epic Medical Research - Oklahoma
state: Oklahoma
city: Oklahoma City
country: United States
facility: Lynn Health Science Institute
state: Oklahoma
city: Oklahoma City
country: United States
facility: Dermatology and Aesthetics of Oklahoma
state: Oklahoma
city: Tulsa
country: United States
facility: Dermatology Research Center of Oklahoma, PLLC
state: Oklahoma
city: Tulsa
country: United States
facility: Essential Medical Research LLC
state: Oklahoma
city: Grants Pass
country: United States
facility: Velocity Clinical Research - Grants Pass
state: Oregon
city: Portland
country: United States
facility: Oregon Health and Science University
state: Oregon
city: Philadelphia
country: United States
facility: Paddington Testing Company Inc
state: Pennsylvania
city: Providence
country: United States
facility: Rhode Island Hospital, Lifespan
state: Rhode Island
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
city: North Charleston
country: United States
facility: National Allergy and Asthma Research, LLC
state: South Carolina
city: Summerville
country: United States
facility: Coastal Pediatric Research
state: South Carolina
city: Morristown
country: United States
facility: HealthStar Physicians Dermatology
state: Tennessee
city: Bellaire
country: United States
facility: The University of Texas Health Science Center at Houston
state: Texas
city: Cedar Park
country: United States
facility: US Dermatology Partners Cedar Park
state: Texas
city: Cypress
country: United States
facility: Studies in Dermatology LLC
state: Texas
city: Houston
country: United States
facility: MedCare Pharma - Houston
state: Texas
city: Houston
country: United States
facility: Tranquil Clinical Research
state: Texas
city: Kerrville
country: United States
facility: Sante Clinical Research
state: Texas
city: Lubbock
country: United States
facility: Long and Harris Dermatology
state: Texas
city: Mesquite
country: United States
facility: Sms Clinical Research Limited Liability Company
state: Texas
city: Missouri City
country: United States
facility: Sienna Dermatology Research
state: Texas
city: San Antonio
country: United States
facility: Texas Dermatology and Laser Specialists
state: Texas
city: Southlake
country: United States
facility: Epiphany Dermatology
state: Texas
city: Sugar Land
country: United States
facility: Pioneer Research Solutions
state: Texas
city: Murray
country: United States
facility: Tanner Clinic
state: Utah
city: Providence
country: United States
facility: Dermatology Research of Utah, dba Providence Dermatology
state: Utah
city: South Jordan
country: United States
facility: Jordan Valley Dermatology Center
state: Utah
city: Franklin
country: United States
facility: Maria M Ona MD PC
state: Virginia
city: Bellevue
country: United States
facility: Northwest Clinical Research Center
state: Washington
city: Bruxelles
country: Belgium
facility: Hopital Erasme
city: Bruxelles
country: Belgium
facility: Universite Catholique de Louvain Cliniques Universitaires Saint Luc
city: Gent
country: Belgium
facility: Universitair Ziekenhuis Gent
city: Liege
country: Belgium
facility: Centre Hospitalier Universitaire de Liege - Sart Tilman
city: Maldegem
country: Belgium
facility: Dermatologie Maldegem
city: Salvador
country: Brazil
facility: Clinica Instituto Bahiano de Imunoterapia - Medicina, Reumatologia e Dermatologia ltda
state: Bahia
city: Vitória
country: Brazil
facility: Centro do Diagnostico e Pesquisa da Osteoporose do Espirito Santo
state: Espírito Santo
city: Belo Horizonte
country: Brazil
facility: Centro de Pesquisa Clínica da Universidade de Belo Horizonte - Unibh
state: Minas Gerais
city: Porto Alegre
country: Brazil
facility: Irmandade da Santa Casa de Misericordia de Porto Alegre
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre
state: Rio Grande Do Sul
city: Jau
country: Brazil
facility: Cecip Centro Est Clin Int Paulista
state: São Paulo
city: Ribeirão Preto
country: Brazil
facility: Le Plume Dermatologia- Clinica de Dermatologia Dra Beatriz Elias Eirelli
state: São Paulo
city: Sao Paulo
country: Brazil
facility: Instituto Pesquisa e Ensino em Saúde Infantil
state: São Paulo
city: Sao Paulo
country: Brazil
facility: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
state: São Paulo
city: São José do Rio Preto
country: Brazil
facility: Hospital de Base de Sao Jose do Rio Preto
state: São Paulo
city: Rio de Janeiro
country: Brazil
facility: IBPClin Instituto Brasil de Pesquisa Clinica
city: Calgary
country: Canada
facility: Rejuvenation Dermatology Laser Calgary North
state: Alberta
city: Markham
country: Canada
facility: Lynderm Research Inc
state: Ontario
city: Newmarket
country: Canada
facility: Dr SK Siddha Medicine Professional Corporation
state: Ontario
city: Niagara Falls
country: Canada
facility: Allergy Research Canada Incorporated
state: Ontario
city: Windsor
country: Canada
facility: XLR8 Medical Research, Incorporated
state: Ontario
city: Saskatoon
country: Canada
facility: Skinsense Medical Research
state: Saskatchewan
city: Osorno
country: Chile
facility: Centro Dermatologico Dermisur
city: Santiago
country: Chile
facility: Centro Medico Skinmed Spa
city: Santiago
country: Chile
facility: Clinica Dermacross SA
city: Santiago
country: Chile
facility: Fundacion Innovacion Cardiovascular
city: Santiago
country: Chile
facility: Centro Internacional de Estudios Clinicos
city: Beijing
country: China
facility: Childrens Hospital Capital Institute of Pediatrics
state: Beijing
city: Beijing
country: China
facility: Peking University Peoples Hospital
state: Beijing
city: Beijing
country: China
facility: Beijing Childrens Hospital, Capital Medical University
state: Beijing
city: Beijing
country: China
facility: Peking University Third Hospital
state: Beijing
city: Chongqing
country: China
facility: Childrens Hospital of Chongqing Medical University
state: Chongqing
city: Guangzhou
country: China
facility: The First Affiliated Hospital Sun-Yat Sen University
state: Guangdong
city: Guangzhou
country: China
facility: Dermatology Hospital of Southern Medical University
state: Guangdong
city: Guangzhou
country: China
facility: Sun Yat-sen Memorial Hospital Sun Yat-sen University
state: Guangdong
city: Nanyang
country: China
facility: Nanyang First Peoples Hospital
state: Henan
city: Wuhan
country: China
facility: The Central Hospital of Wuhan
state: Hubei
city: Wuhan
country: China
facility: Union Hospital Tongji Medical College Huazhong University of Science and Technology
state: Hubei
city: Jiangyin
country: China
facility: Jiangyin Hospital of Traditional Chinese Medicine
state: Jiangsu
city: Changchun
country: China
facility: The First Bethune Hospital of Jilin University
state: Jilin
city: Dalian
country: China
facility: Dalian Women and Childrens Medical Group
state: Liaoning
city: Yinchuan
country: China
facility: General Hospital of Ningxia Medical University
state: Ningxia
city: Shanghai
country: China
facility: Shanghai Skin Disease Hospital
state: Shanghai
city: Chengdu
country: China
facility: Chengdu Second Peoples Hospital
state: Sichuan
city: Suining
country: China
facility: Suining Central Hospital
state: Sichuan
city: Kunming
country: China
facility: Kunming Childrens Hospital
state: Yunnan
city: Hangzhou
country: China
facility: Affiliated Hangzhou First Peoples Hospital School of Medicine Westlake University
state: Zhejiang
city: Ningbo
country: China
facility: Ningbo NO 2 Hospital
state: Zhejiang
city: Taizhou
country: China
facility: Taizhou Central Hospital
state: Zhejiang
city: Changsha
country: China
facility: Hunan Childrens Hospital
city: Shenzhen
country: China
facility: Shenzhen Childrens Hospital
city: Ivanic-Grad
country: Croatia
facility: Special Hospital for Medical Rehabilitation Naftalan
city: Osijek
country: Croatia
facility: University Hospital Centre Osijek
city: Zagreb
country: Croatia
facility: Children s Hospital Zagreb
city: Zagreb
country: Croatia
facility: Sestre milosrdnice University Hospital Center
city: Zagreb
country: Croatia
facility: University Hospital Centre Zagreb
city: Antony
country: France
facility: Hopital Prive d Antony
city: Brest
country: France
facility: Centre Hospitalier Regional Universitaire Brest Hopital Morvan
city: Marseille Cedex 8
country: France
facility: Hôpital Saint-Joseph
city: Nantes
country: France
facility: Centre Hospitalier Universitaire de Nantes Hôtel Dieu
city: Rennes Cedex 9
country: France
facility: Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
city: Rouen Cedex
country: France
facility: Centre Hospitalier Universitaire de Rouen - Hôpital Charles Nicolle
city: Toulouse
country: France
facility: Centre Hospitalier Universitaire de Toulouse, Hopital Larrey
city: Bad Bentheim
country: Germany
facility: Fachklinik Bad Bentheim
city: Bonn
country: Germany
facility: Universitaetsklinikum Bonn
city: Darmstadt
country: Germany
facility: Rosenpark Research GmbH
city: Dresden
country: Germany
facility: Universitaetsklinikum Dresden
city: Erlangen
country: Germany
facility: Universitaetsklinikum Erlangen
city: Frankfurt am Main
country: Germany
facility: Klinikum und Fachbereich Medizin Johann Wolfgang Goethe-Universitaet Frankfurt am Main
city: Leipzig
country: Germany
facility: Velocity Clinical Research
city: Mainz
country: Germany
facility: Johannes Gutenberg Universitaet Mainz
city: Athens
country: Greece
facility: Athens Naval Hospital
city: Athens
country: Greece
facility: Athens General Childrens Hospital Panagioti And Aglaia Kyriakou
city: Athens
country: Greece
facility: Thoracic General Hospital Of Athens Sotiria
city: Thessaloniki
country: Greece
facility: Ippokratio General Hospital of Thessaloniki
city: Budapest
country: Hungary
facility: Clinexpert Kft
city: Debrecen
country: Hungary
facility: Derma-B Egeszsegugyi es Szolgaltato Kft
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Kozpont
city: Kaposvar
country: Hungary
facility: Somogy Varmegyei Kaposi Mor Oktato Korhaz
city: Bear Sheva
country: Israel
facility: Soroka Medical Center
city: Ramat Gan
country: Israel
facility: Sheba Medical Center
city: Tel Aviv
country: Israel
facility: Sourasky Medical Center
city: Milano
country: Italy
facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
city: Napoli
country: Italy
facility: Azienda Ospedaliera Universitaria Luigi Vanvitelli
city: Perugia
country: Italy
facility: Azienda Ospedaliera di Perugia Ospedale Santa Maria della Misericordia
city: Torino
country: Italy
facility: Presidio Molinette Azienda Ospedaliera Citta della Salute e della Scienza di Torino
city: Nagoya-shi
country: Japan
facility: Central Clinic
state: Aichi
city: Matsudo-shi
country: Japan
facility: Miyata Dermatology Clinic
state: Chiba
city: Fukuoka-shi
country: Japan
facility: Matsuo Clinic
state: Fukuoka
city: Asahikawa-shi
country: Japan
facility: Asahikawa City Hospital
state: Hokkaido
city: Obihiro-shi
country: Japan
facility: Takagi Dermatological Clinic
state: Hokkaido
city: Akashi-shi
country: Japan
facility: Yoshimura Child Clinic
state: Hyogo
city: Kagoshima-shi
country: Japan
facility: Katahira Dermatology Urology Clinic
state: Kagoshima
city: Yokohama-shi
country: Japan
facility: Nomura Dermatology Clinic
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Yokohama City Minato Red Cross Hospital
state: Kanagawa
city: Kumamoto-shi
country: Japan
facility: Jouzan Hihuka Hinyoukika Clinic
state: Kumamoto
city: Kumamoto-shi
country: Japan
facility: Suizenji Dermatology Clinic
state: Kumamoto
city: Neyagawa-shi
country: Japan
facility: Yoshioka Dermatology Clinic
state: Osaka
city: Sakai-shi
country: Japan
facility: Dermatology and Ophthalmology Kume Clinic
state: Osaka
city: Hamamatsu-shi
country: Japan
facility: Hamamatsu University Hospital
state: Shizuoka
city: Setagaya-ku
country: Japan
facility: Naoko Dermatology Clinic
state: Tokyo
city: Shinagawa-ku
country: Japan
facility: NTT Medical Center Tokyo
state: Tokyo
city: Ansansi, Gyeonggido
country: Korea, Republic of
facility: Korea University Ansan Hospital
city: Seoul
country: Korea, Republic of
facility: Nowon Eulji Medical Center, Eulji University
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital Yonsei University Health System
city: Seoul
country: Korea, Republic of
facility: National Medical Center
city: Seoul
country: Korea, Republic of
facility: Kyung Hee University Hospital at Gangdong
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea Seoul St Marys Hospital
city: Seoul
country: Korea, Republic of
facility: Chung-Ang University Hospital
city: Seoul
country: Korea, Republic of
facility: Hallym University Kangnam Sacred Heart Hospital
city: Seoul
country: Korea, Republic of
facility: Ewha Womans University Seoul Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
city: Toluca
country: Mexico
facility: Phylasis Clinicas Research Toluca
city: Gdansk
country: Poland
facility: Uniwersyteckie Centrum Kliniczne
city: Gdansk
country: Poland
facility: AKK Medical Spolka z ograniczona odpowiedzialnoscia Centrum Medyczne Tu sie leczy
city: Katowice
country: Poland
facility: GynCentrum Sp zoo NZOZ Holsamed
city: Katowice
country: Poland
facility: Centrum Medyczne Angelius Provita
city: Krakow
country: Poland
facility: Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy Marek Brzewski Pawel Brzewski SpCywilna
city: Krakow
country: Poland
facility: Diamond Clinic Spolka z Ograniczona Odpowiedzialnoscia Diamond Medical Center
city: Lodz
country: Poland
facility: AppleTreeClinics Network Spzoo
city: Lodz
country: Poland
facility: Amicare Spolka z ograniczona odpowiedzialnoscia Spolka Komandytowa Amicare Centrum Medyczne
city: Lublin
country: Poland
facility: Clinical Best Solutions Sp zoo Spolka Komandytowa
city: Sosnowiec
country: Poland
facility: Centrum Zdrowia Dziecka i Rodziny Im Jana Pawla II w Sosnowcu Osrodek Badan Klinicznych
city: Tarnow
country: Poland
facility: Alergo-Med Specjalistyczna Przychodnia Lekarska Spzoo
city: Warszawa
country: Poland
facility: Klinika Osipowicz and Turkowski Sp zoo
city: Warszawa
country: Poland
facility: High Med Przychodnia Specjalistyczna
city: Warszawa
country: Poland
facility: Klinika Ambroziak Dermatologia
city: Warszawa
country: Poland
facility: Royalderm Agnieszka Nawrocka
city: Wroclaw
country: Poland
facility: Dermatologiczna Praktyka Lekarska Michal Torz Dermaceum Centrum Badan Klinicznych
city: San Juan
country: Puerto Rico
facility: Clinical Research of Puerto Rico
city: San Juan
country: Puerto Rico
facility: Gcm Medical Group, Psc
city: Bucharest
country: Romania
facility: Dr Leventer Centre Clinica Dermatologie Bucuresti
city: Cluj-Napoca
country: Romania
facility: Derma Cluj
city: Cluj-Napoca
country: Romania
facility: Institutul Regional de Gastroenterologie si Hepatologie Prof Dr Octavian Fodor
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
state: Cataluña
city: Esplugues de Llobregat
country: Spain
facility: Hospital Sant Joan de Deu
state: Cataluña
city: Pamplona
country: Spain
facility: Clinica Universidad de Navarra
state: Navarra
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Maranon
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Chang Gung Memorial Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taoyuan
country: Taiwan
facility: Linkou Chang Gung Memorial Hospital
city: Bangkok
country: Thailand
facility: King Chulalongkorn Memorial Hospital
city: Bangkok
country: Thailand
facility: Siriraj Hospital
city: Chiang Mai
country: Thailand
facility: Maharaj Nakorn Chiang Mai Hospital
city: Pathum Thani
country: Thailand
facility: Thammasat University Hospital
Study officials:
affiliation: Amgen
name: MD
role: STUDY_DIRECTOR
References: