Clinical trial NCT00249457: Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 2
Official title: A Therapeutic Workplace for Drug Abusers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Behavior, Addictive
Cocaine Abuse
Cocaine Dependence
Heroin Dependence
Opioid Dependence
Keywords: Behavior Therapy
Cocaine Abuse
Cocaine Dependence
Contingency Management
Heroin Dependence
Methadone
Opioid Dependence
Lead sponsor: Johns Hopkins University
Sponsor class: OTHER
First posted: 2005-11-07
Enrollment: 40
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether long-term exposure to the Therapeutic Workplace intervention could sustain drug abstinence over an extended period of time in heroin- and cocaine-dependent, unemployed, treatment-resistant young mothers.

Detailed description: The current study is a continuation of the research into the development and evaluation of a novel treatment designed to address the chronic, persistent nature of drug addiction. This treatment, called the Therapeutic Workplace, integrates abstinence reinforcement contingencies of proven efficacy into a model supported work program. Participants were paid to work or to train in the Therapeutic Workplace but had to provide drug-free urine samples to gain daily access. Forty participants were randomly assigned to a Therapeutic Workplace or usual care control group. Therapeutic Workplace participants could work for about 5 years. This study reports the effects of the intervention over a follow-up period of 8 years after treatment initiation.

Eligibility criteria: Inclusion Criteria:

* When originally enrolled in the study, participants were at least 18 years old, unemployed, and methadone maintenance patients of the Center for Addiction and Pregnancy (CAP) who continued to use opiates or cocaine during CAP treatment.

Exclusion Criteria:

* Participants were excluded if they were at risk for suicide at the time of intake or if they had serious psychiatric illness (e.g., schizophrenia).

Primary outcomes:
measure: Percentage of urine samples at the assessments that were negative for cocaine
timeFrame: every 30 days throughout fourth year
measure: Percentage of urine samples at the assessments that were negative for opiates
timeFrame: every 30 days throughout fourth year
measure: Percentage of urine samples at the assessments that were negative for cocaine and opiates
timeFrame: every 30 days throughout fourth year
Secondary outcomes:
measure: HIV risk behaviors
timeFrame: every 30 days throughout fourth year
measure: Percentage of participants employed each month
timeFrame: every 30 days throughout fourth year
measure: Number of days employed each month
timeFrame: every 30 days throughout fourth year
measure: Percentage of participants to self-report abstinence at all time points
timeFrame: every 30 days throughout fourth year
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: The Center for Learning and Health
state: Maryland
Study officials:
affiliation: Johns Hopkins University
name: Kenneth Silverman, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Aklin WM, Wong CJ, Hampton J, Svikis DS, Stitzer ML, Bigelow GE, Silverman K. A therapeutic workplace for the long-term treatment of drug addiction and unemployment: eight-year outcomes of a social business intervention. J Subst Abuse Treat. 2014 Nov-Dec;47(5):329-38. doi: 10.1016/j.jsat.2014.06.013. Epub 2014 Jul 12.