Clinical trial NCT04277091: Upper-body High-intensity Interval Training and Mixed Meal Responses
Official title: The Effect of Upper-body High-intensity Interval Exercise vs. Moderate-intensity Continuous Exercise on Postprandial Metabolism
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: High-Intensity Interval Training
Keywords: postprandial metabolism
Lead sponsor: University of Bath
Sponsor class: OTHER
First posted: 2020-02-20
Enrollment: 11
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: Cycling and running-based high-intensity interval training are well-established to improve a variety of health outcomes. However, the efficacy of upper-body high-intensity interval training, vital for individuals with lower-body impairments, has yet to be well-characterized. The purpose of this study is to compare the effect of a single bout of upper-body high-intensity interval exercise (HIIE) in comparison to traditional moderate-intensity continuous exercise (MICE) on the blood response (e.g. glucose, insulin, fats) following a meal.

This study is recruiting able-bodied adults (aged 18-65 years). Participants will need to attend the laboratory at the University of Bath for two preliminary sessions, and three main study trials.

Detailed description: The aim of this research is to determine the metabolic responses to a mixed-meal tolerance test following an acute bout of HIIE and an energy-matched MICE bout in able-bodied persons. The hypothesis is that HIIE and MICE will be more effective at reducing the total triglyceride responses compared to a resting control condition.

Preliminary measurements:

Preliminary testing will include measurements of weight and height. There will also be an assessment of resting metabolic rate and maximal exercise capacity. On a second visit, a HIIE familiarisation session will be performed to determine total energy expenditure of the session. All of the exercise protocols will take place on an arm crank ergometer at the University of Bath.

Main trial days:

Before all main trials, participants will be asked to refrain from performing any strenuous physical activity in the 48-h prior (i.e. day 0 and 1) and consuming alcohol/caffeine in the 24-h prior (i.e. day 1). On day 1, participants will be asked to record/replicate their diet using a weighed food-diary. Participants will be asked perform exercise (HIIE and MICE only) at 18:00 on day 1, having consumed no food (other than plain water) from 14:00. They will be given a standardised dinner to eat at 20:00, and asked to avoid the ingestion of any further food (other than plain water) for the rest of the evening.

On day 2 and upon arrival to the laboratory, a cannula will be inserted into a vein, and a baseline blood sample and expired air sample will be taken. The participant will then be asked to consume a smoothie, consisting of peanut butter, banana, coconut oil, sugar, and chocolate-flavoured whey protein powder. The meal should be consumed within 10 minutes and blood samples will be taken from the cannula at 15, 30, 45 60, and 90 minutes and then at every hour for 5 hours after consumption of the meal to monitor changes in metabolic markers. Expired gas samples will also be taken hourly and indirect calorimetry will be used to estimate relative fat and carbohydrate metabolism in response to the meal.

Eligibility criteria: Inclusion Criteria:

* Non-smoker
* No history of cardiovascular, metabolic, or neuromuscular disease

Exclusion Criteria:

* Individuals with a nut allergy

Primary outcomes:
measure: Postprandial triglyceride concentrations
timeFrame: 5 hours
Secondary outcomes:
measure: Postprandial glucose concentrations
timeFrame: 5 hours
measure: Postprandial insulin concentrations
timeFrame: 5 hours
measure: Postprandial substrate oxidation
timeFrame: 5 hours
measure: Rating of Perceived Exertion
timeFrame: HIIE: End of Warm-Up, 8 min, 12 min, 16 min, 20 min, 24 min. MICE: 0, 20, 40, 60, 80, 100% through exercise session (exact time points dependent on exercise time for each participant)
measure: Heart Rate
timeFrame: HIIE: End of Warm-Up, 8 min, 12 min, 16 min, 20 min, 24 min. MICE: 0, 20, 40, 60, 80, 100% through exercise session (exact time points dependent on exercise time for each participant)
measure: Affect
timeFrame: HIIE: End of Warm-Up, 8 min, 12 min, 16 min, 20 min, 24 min. MICE: 0, 20, 40, 60, 80, 100% through exercise session (exact time points dependent on exercise time for each participant)
measure: Exercise Enjoyment
timeFrame: 30 min post-exercise
measure: Self-efficacy
timeFrame: 30 min post-exercise
Other outcomes:
Locations:
city: Bath
country: United Kingdom
facility: Department for Health
Study officials:
affiliation: University of Bath
name: James Bilzon
role: PRINCIPAL_INVESTIGATOR
References: