Clinical trial NCT06627491: Influence of Fast and Slow Imagined Muscle Contractions on Muscle Function or Central Nervous System Properties
Official title: Does the Speed of Imagined Muscle Contractions Affect Muscle Function and Central Nervous System Excitability?
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Healthy
Keywords: Muscle strength
Nervous System
Motor Imagery
Lead sponsor: Kennesaw State University
Sponsor class: OTHER
First posted: 2024-10-04
Enrollment: 18
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The goal of this randomized clinical trial is to learn if imagining fast or slow muscle contractions causes different responses for nervous system excitability and muscle function in young, healthy males and females in. The main questions are:

Does imagining fast muscle contractions cause greater nervous system excitability compared to imagining slow muscle contractions?

Does imagining fast muscle contractions increase muscle function compared to imagining slow muscle contractions?

A control condition (rest) will be compared with two intervention conditions: imagining fast and imagining slow conditions, to determine if the fast and slow increase outcomes more than control and if fast has the greatest response.

Participants will:

* Attend 4 laboratory visits
* Perform 50 imagined contractions fast or slow, but with no physical movement
* Physical muscle contractions and non-invasive brain stimulation would be completed before and after each condition.

Detailed description: Participants will complete 4 laboratory visits in a randomized order, including a familiarization session, a control condition, and 2 conditions involving imaginary muscle contractions. During visits involving imaginary muscle contractions, participants will complete 2 sets of 25 repetitions of either fast (i.e., less than 1 second to peak torque increase torque as fast as possible) or slow (i.e., 3 seconds to peak torque) isometric elbow flexions. Before and after each condition, single-pulse transcranial magnetic stimulation will be delivered to the primary motor cortex to measure the amplitude of motor-evoked potentials and the duration of the resulting silent periods in the bicep brachii to quantify changes in corticospinal excitability and inhibition, respectively. Rapid maximal voluntary isometric contractions will be used to measure changes in rate of torque development, peak torque, and rate of muscle activation.

Eligibility criteria: Inclusion Criteria:

* Be between the ages of 18 - 30
* Healthy (no medical conditions)
* If female, must be taking the same monophasic oral contraceptive for the past 6 months
* Have a body mass index between 18.5 - 30 kg/m2
* Have not performed structured cardiovascular or resistance exercise in past 3 years
* Be right-handed
* Not currently taking stimulants, antipsychotic, anxiety, or depression medications
* Have not suffered an upper extremity musculoskeletal injury within the past year

Exclusion Criteria:

* If transcranial magnetic stimulation (TMS) is not deemed appropriate depending on your responses to the TMS-specific questionnaire
* Being ambidextrous
* Although rare, you will be excluded if discernable muscle activation responses are not possible via TMS

Primary outcomes:
measure: Change in rate of torque development as measured by newton-meters per second
timeFrame: Baseline, minute 20
measure: Change in nervous system excitability as measured by electromyographic waveform aplitude following motor cortex stimulation
timeFrame: Baseline, minute 20
Secondary outcomes:
measure: Change in isometric bicep strength as measured by newton-meters of torque
timeFrame: Baseline, minute 20
measure: Change in agonist muscle activation as measured by electromyography amplitude
timeFrame: Baseline, minute 20
measure: Change in antagonist co-activation as measured by electromyography amplitude
timeFrame: Baseline, minute 20
measure: Change in rate of agonist muscle activation as measured by electromyography amplitude
timeFrame: Baseline, minute 20
measure: Change in nervous system inhibition as measured by electromyographic waveform aplitude following motor cortex stimulation
timeFrame: Baseline, minute 20
Other outcomes:
measure: Self-reported ability to imagine movements as measured by Movement Imagery Questionnaire-Revised as measured on a scale from 8 to 56
timeFrame: Baseline
measure: Level of vividness for imagining the imagined contractions as measured by 7-point likert scale as measured from 1 to 7
timeFrame: 20 minutes after baseline
Locations:
city: Kennesaw
country: United States
facility: Kennesaw State University
state: Georgia
Study officials:
References: