Clinical trial NCT06330467: Prevalence of Dissociative Identity Disorder in At-risk Outpatient Groups Reporting Childhood Trauma.
Official title: Prevalence of Dissociative Identity Disorder in At-risk Outpatient Groups Reporting Childhood Trauma.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Dissociative Disorder
Keywords: Dissociative Identity Disorder (DID)
Psychosis
Functional Dissociative Crises (FDC)
Complex PTSD
Borderline
Lead sponsor: Centre Psychothérapique de Nancy
Sponsor class: OTHER
First posted: 2024-03-26
Enrollment: 350
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 3 groups : borderline, early psychosis and FDC.
Primary purpose: DIAGNOSTIC

Brief summary: The investigators will study the prevalence of dissociative identity disorder (DID) in three populations at risk in cases of childhood psychotrauma : patients with a diagnosis of borderline personality, patients with a diagnosis of functional dissociative crises (FDC) and patients with early psychosis.

The investigators will also study the prevalence of other dissociative disorders and the frequency of complex post-traumatic stress disorder.

The investigators will also look for correlations between the type of maltreatment in childhood, the age of onset of trauma and the type of diagnosis of dissociative disorders.

The investigators hope to include 150 borderline patients, 150 FDC patients and 50 early psychosis patients.

Data collection will be done via a psychometric administration of 7 self-completion questionnaires as well as the completion of the SCID-D semi-structured interview.


Eligibility criteria: I - Inclusion Criteria:

I-1: For all groups:

* Male or female
* Age \> or = 18
* Enrolled in or benefiting from a social security scheme
* Patient fluent in French
* Patient willing to undergo a psychological evaluation between 1h30 and 3h30
* Patient with a known history of psychotrauma in childhood before the age of 18 (sexual abuse, mistreatment, school harassment, natural disasters, attacks, etc.).
* Patient having received and understood complete information on the organization of the research and having given written free and informed consent prior to participation in the study.

I-2 : Patients in the borderline group

* Patients with main diagnosis of emotionally labile personality
* Patients with at least one psychiatric hospitalization in the last 3 years

I-3 : Patients in the early psychosis group

Patient with a diagnosis of mental state at risk of psychosis according to the criteria defined by CAARMS (Comprehensive Assessment of At Risk Mental State) OR Patients diagnosed with a first psychotic episode on an outpatient basis or following a hospital stay

I-4 : Patients in the functional dissociative crises group

Patients diagnosed with functional dissociative crises by a specialized epileptologist

II- Non-inclusion criteria

* Impairment of the subject making it difficult or not impossible to participate in the trial or to understand the information provided to him/her
* Patients with specific difficulties in understanding SCID-D questions
* Psychiatric condition requiring hospitalization
* Patients with symptoms of recent toxic consumption (alcohol, cannabis, other ...) disrupting assessment responses
* Patient taking part in a pharmacological study involving a pro-dissociative molecule of the psychedelic type
* Pregnant, parturient or nursing mothers
* Person deprived of liberty by judicial or administrative decision
* Person in a life-threatening emergency
* An adult under legal protection (guardianship, curatorship, safeguard of justice)
* Person unable to give consent and not subject to a legal protection measure

Primary outcomes:
measure: SCID-D : Semi-structured Clinical Interview for diagnosing DSM-5 and ICD-11 Dissociative Disorders / DSM = Diagnostic and Statistical Manual of Mental Disorders / ICD = International Classification of Diseases
timeFrame: Inclusion visit
Secondary outcomes:
measure: SCID-D : Semi-structured Clinical Interview for diagnosing DSM-5 and ICD-11 Dissociative Disorders
timeFrame: Inclusion visit
measure: CTQ-28 : Childhood Trauma Questionnaire
timeFrame: Inclusion visit
measure: life events inventory DSM-5
timeFrame: Inclusion visit
measure: PCL-5 : Posttraumatic stress disorder CheckList-5
timeFrame: Inclusion visit
measure: ITQ : International Trauma Questionnaire
timeFrame: Inclusion visit
measure: SDQ-20 : Somatoform Dissociative questionnaire
timeFrame: Inclusion visit
measure: DIS-Q : Dissociation Questionnaire
timeFrame: Inclusion visit
measure: DES : Dissociative Experience Scale
timeFrame: Inclusion visit
Other outcomes:
Locations:
city: Nancy
country: France
facility: Centre Psychothérapique de Nancy - CLIP
city: Nancy
country: France
facility: Centre Psychothérapique de Nancy - CMP Jacquard et Des Près
city: Nancy
country: France
facility: CHRU Nancy - Neurology department
Study officials:
affiliation: Centre Psychothérapique de Nancy
name: Coraline HINGRAY
role: PRINCIPAL_INVESTIGATOR
References: