Clinical trial NCT00643266: Recollection Training in Healthy Older Adults and Older Adults With Amnestic Mild Cognitive Impairment
Official title: Memory Interventions for Older Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Amnestic Mild Cognitive Impairment
Aging
Keywords: recollection training
aging
amnestic mild cognitive impairment
fMRI
Lead sponsor: Baycrest
Sponsor class: OTHER
First posted: 2008-03-26
Enrollment: 91
Sex: ALL
Minimum age (years): 65
Maximum age (years): 90
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: We have developed a training intervention that successfully improves older adults' memory. We have also shown that older adults whose memory is as good as younger adults' memory (Hi-Old) use an altered pattern of memory-related brain activity compared to younger adults, whereas healthy older adults with poorer memory (Lo-Old) do not. We have also shown that individuals with amnestic Mild Cognitive Impairment (aMCI) have impairments of conscious, effortful, Recollection-based memory processes, whereas their automatic, Familiarity-based memory processes are intact. Our primary current goal is to investigate whether our successful memory intervention will improve Recollection and produce induce altered patterns of brain activity in the Lo-Old and aMCI.

Young, Lo-Old, Hi-Old, and aMCI will be scanned using functional magnetic resonance imaging while performing two memory tasks. Half of the Lo-Old and half of the aMCI will then receive the memory intervention, while the other half in each group will receive a control program consisting of information and games about aging. The Lo-Old and aMCI will then be rescanned while performing the two memory tasks. We predict that the memory intervention will improve performance on a number of memory tasks, and will induce altered patterns of brain activity. In the Lo-Old, their brain activity after the memory intervention will look more like the Hi-Old, while brain activity will become more focal in the aMCI.


Eligibility criteria: Inclusion Criteria:

* 65-90 years old
* English as a first language or learned before kindergarten
* Right handed

Exclusion Criteria:

* Neurologic disorder
* Major medical disorder affecting cognition
* Psychiatric disorder
* Metal in the body that poses a hazard in the MRI scanner

Primary outcomes:
measure: Recollection estimates
timeFrame: Immediately post-training and three months post-training
Secondary outcomes:
measure: Brain activation as assessed by functional magnetic resonance imaging
timeFrame: Immediately post-training
measure: Transfer to other recollection-dependent task and to subjective memory measures
timeFrame: Immediately post-training and three months post-training
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Baycrest
state: Ontario
Study officials:
affiliation: Baycrest
name: Nicole D Anderson, PhD, CPsych
role: PRINCIPAL_INVESTIGATOR
References:
citation: Anderson ND, Ebert PL, Jennings JM, Grady CL, Cabeza R, Graham SJ. Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment. Neuropsychology. 2008 Mar;22(2):177-87. doi: 10.1037/0894-4105.22.2.177.
citation: Guild EB, Vasquez BP, Maione AM, Mah L, Ween J, Anderson ND. Dynamic working memory performance in individuals with single-domain amnestic mild cognitive impairment. J Clin Exp Neuropsychol. 2014;36(7):751-60. doi: 10.1080/13803395.2014.941790. Epub 2014 Aug 30.
citation: Ebert PL, Anderson ND. Proactive and retroactive interference in young adults, healthy older adults, and older adults with amnestic mild cognitive impairment. J Int Neuropsychol Soc. 2009 Jan;15(1):83-93. doi: 10.1017/S1355617708090115.
citation: Anderson ND, Ebert PL, Grady CL, Jennings JM. Repetition lag training eliminates age-related recollection deficits (and gains are maintained after three months) but does not transfer: Implications for the fractionation of recollection. Psychol Aging. 2018 Feb;33(1):93-108. doi: 10.1037/pag0000214.
citation: Meusel LA, Grady CL, Ebert PE, Anderson ND. Brain-behavior relationships in source memory: Effects of age and memory ability. Cortex. 2017 Jun;91:221-233. doi: 10.1016/j.cortex.2016.12.023. Epub 2017 Jan 12.