Clinical trial NCT03633162: Maternal Grandmothers in the Born in Guangzhou Cohort Study
Official title: Maternal Grandmothers in the Born in Guangzhou Cohort Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Hereditary Transmission
Immune Development
Childhood Obesity
Host and Microbiome
Neurodevelopment
Keywords: Maternal Grandmother
Genes
Immune
Cohort
Child development
Lead sponsor: Guangzhou Women and Children's Medical Center
Sponsor class: OTHER
Collaborators: name: Children's Hospital Medical Center, Cincinnati
name: University of Birmingham
First posted: 2018-08-16
Enrollment: 5000
Sex: FEMALE
Minimum age (years): 36
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All maternal grandmothers of the children in the Born in Guangzhou Cohort Study (BIGCS) would be recruited.

Brief summary: The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.

Detailed description: It was previously believed that heredity strictly follows Mendel's laws, but recent studies have found that through placental material exchange, mammals may transfer maternal immune-related factors vertically, thus promoting the protection of "non-heredited maternal antigenic traits". Thus, the transmission of reproductive information across generations is realized. Since the unusual genetic pattern of the X chromosome, grandmother's influence may be gender specific. Since grandchildren were usually took care by grandparents in China, it could be achievable to attach and recruit maternal grandmother together with mother and children. Cohort including three generations of women is rare in Asia at present. In the MGBIG, extensive information including demographic characteristics, lifestyle, history of diseases, mental health, and behaviors is collected from the participants. Longitudinal follow up and surveillance of common chronic diseases are also to be conducted. The MGBIG intends to recruit maternal grandmothers to study the effects of maternal genetic and environmental exposure on the health of their children and grandchildren.

Eligibility criteria: Inclusion Criteria:

1. Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center
2. Baseline information of maternal grandmother's daughter during pregnancy available

Exclusion Criteria:

1. Significant cardiovascular abnormalities
2. Intelligent obstacle, intellectual disabilities or gawkish condition

Primary outcomes:
measure: Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring
timeFrame: From the date of her daughter get pregnant until the date her grandchild/grandchildren is/are given birth
Secondary outcomes:
measure: Serum levels of Inflammatory factors at grandchildren's birth and early neonatal life
timeFrame: At the birth date of her grandchild/grandchildren, at the date 42 days after the birth of the certain grandchild/grandchildren
measure: The prevalence of eczema of grandchildren
timeFrame: At the age of 6 weeks, 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
measure: The incidence of asthma of grandchildren
timeFrame: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
measure: The prevalence of Allergic rhinitis of grandchildren
timeFrame: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
measure: The prevalence of Food allergy of children and grandchildren
timeFrame: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
measure: Changes of body composition of grandchildren
timeFrame: At age of 3 years,6 years, 12years and 18years
measure: Changes of bone density of grandchildren
timeFrame: At age of 3 years,6 years, 12years and 18years
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Guangzhou Women and Children's Medical Center
state: Guangdong
Study officials:
affiliation: Guangzhou Women and Children's Medical Center, China
name: Xiu Qiu, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM. The Born in Guangzhou Cohort Study (BIGCS). Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-0239-x. Epub 2017 Mar 20.
citation: Kinder JM, Jiang TT, Ertelt JM, Xin L, Strong BS, Shaaban AF, Way SS. Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells. Cell. 2015 Jul 30;162(3):505-15. doi: 10.1016/j.cell.2015.07.006. Epub 2015 Jul 23.