Clinical trial NCT05600673: Combined CO2 Fractional Laser With Bimatoprost 0.03% Treatment of Alopecia Areata
Official title: Efficacy of Combined CO2 Fractional Laser With Bimatoprost 0.03% in Treatment of Alopecia Areata
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Alopecia Areata
Keywords: Alopecia areata
Bimatoprost
CO2 Fractional Laser
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2022-10-31
Enrollment: 30
Sex: ALL
Minimum age (years): 16
Maximum age (years): 55
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: In this design, subjects are randomized to 2 study arms and each study arm will be allocated a different intervention. After randomization each participant will stay in their assigned treatment arm for the duration of the study.
Primary purpose: TREATMENT

Brief summary: The goal of this study is to evaluate the efficacy and safety of combined CO2 fractional laser with Bimatoprost 0.03% as novel treatment of alopecia areata.

The main question to study is will the bimatoprost facilitate hair growth if added to fractional CO2 laser treatment in Alopecia areata.

Detailed description: The study included 30 patients who were diagnosed clinically and dermoscopically as alopecia areata with age ranged between 16-55 years. The patients are divided into 2 groups: Group I, received fractional laser sessions with immediate and daily Bimatoprost application and Group II, received only frequent Laser sessions. Laser sessions were given to each patch once every 3 weeks, the procedure was repeated for 3 times.

Eligibility criteria: Inclusion Criteria:

* Patients with alopecia areata of the scalp (multilocuolaris or single patch).
* Patient aged from 16- 55 years old in both sex.
* Other treatment wash out period is two months.

Exclusion Criteria:

* Ophiasis pattern and other patterns of alopecia areata.
* Chronic diseases of liver, heart, kidney and blood
* Pregnant women
* Infections of skin in site of intervention

Primary outcomes:
measure: Hair regrowth
timeFrame: 9 weeks
Secondary outcomes:
measure: Side effects
timeFrame: 9 weeks
measure: Follow up assessment
timeFrame: 9 weeks
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: AL-Azhar University Hospital
Study officials:
References:
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citation: Alkhalifah A, Alsantali A, Wang E, McElwee KJ, Shapiro J. Alopecia areata update: part II. Treatment. J Am Acad Dermatol. 2010 Feb;62(2):191-202, quiz 203-4. doi: 10.1016/j.jaad.2009.10.031.
citation: Vila TO, Camacho Martinez FM. Bimatoprost in the treatment of eyelash universalis alopecia areata. Int J Trichology. 2010 Jul;2(2):86-8. doi: 10.4103/0974-7753.77511.
citation: Wang W, Gegentana, Tonglaga, Bagenna, Li Y. Treatment of alopecia areata with nonablative fractional laser combined with topical minoxidil. J Cosmet Dermatol. 2019 Aug;18(4):1009-1013. doi: 10.1111/jocd.12883. Epub 2019 Jun 6.
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