louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01747694: Respiratory Muscle Exercise Training in COPD Patients
Official title: The Effectiveness of Multi-respiratory Muscle Training on Respiratory Function in Patients With COPD
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: COPD
Keywords: COPD,Respiratory muscle training,Exercise tolerance
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2012-12-12
Enrollment: 60
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: COPD patients often suffer from dyspnea and exercise intolerance which lower their quality of life.The aim of this proposed study is to examine the effectiveness of multi-respiratory muscle training on respiratory function of COPD patients.

Detailed description: The respiratory muscle training is an important part of pulmonary rehabilitation. Subjects will be recruited from the chest medicine clinic of a medical center in Northern Taiwan, randomly assigned to control and experimental groups by severity status for a 12-week muscle training intervention.The outcome measures will be performed to evaluate respiratory function, depression status and quality of life at baseline, 4, 8 and 12 weeks of training.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of Chronic Obstructive Pulmonary Disease
* Must be stable
* Never participate in respiratory muscle trainig program

Exclusion Criteria:

* Infection or acute excerbation condition
* Abdominal surgical
* Severe neuromuscular, cardiac disease or dementia

Primary outcomes:
measure: PE max
timeFrame: three months
Secondary outcomes:
measure: PI max
timeFrame: three months
measure: 6MWT
timeFrame: three months
measure: MVV
timeFrame: three months
Other outcomes:
measure: St. George's Respiratory Questionnaire
timeFrame: three months
measure: CES-D
timeFrame: three months
Locations:
city: Taoyuan
country: Taiwan
facility: Chang Gung Memorial Hospital
Study officials:
affiliation: Chang Gung Memorial Hospital
name: Shu-Chuan Ho, PhD
role: STUDY_CHAIR
affiliation: Department of Healthcare Administration,Asia University
name: Min-Fang Hsu, PhD student
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03409094: Dongguan Eye Study of Schoolchildren and Adolescents（DESSA）
Official title: A Study on Ocular Biometry Measurement of Schoolchildren and Adolescents in China
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Child Development
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2018-01-24
Enrollment: 0
Sex: ALL
Minimum age (years): 7
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Schoolchildren and adolescents ranging from 7 to 18 years old in Dongguan.

Brief summary: This is a study to report the change of ocular biometry of schoolchildren and adolescents as well as its association with birth parameters in China.


Eligibility criteria: Inclusion Criteria:

* Schoolchildren and adolescents aged 7 to18 years in Dongguan
* Parents are willing to sign the informed written consent.

Exclusion Criteria:

* Those without informed written consent or unable to obey the study procedures

Primary outcomes:
measure: Changes of ocular fundus parameter in schoolchildren and adolescents
timeFrame: 3 years
Secondary outcomes:
measure: Changes of ocular biometry measurement in schoolchildren and adolescents
timeFrame: 3 years
measure: Changes of ocular anterior segment in schoolchildren and adolescents
timeFrame: 3 years
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Zhongshan Ophthalmic Center
state: Guangdong
Study officials:
affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University
name: Xiulan Zhang, MD,PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02501694: Evaluation of Patients With Suspected Endofibrosis
Official title: Enregistrement Des Bruits Vasculaires de l'artère Iliaque Externe Par STETHOscope électronique en Post - Effort Chez le SPORTif
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Peripheral Artery Disease
Lead sponsor: University Hospital, Angers
Sponsor class: OTHER_GOV
First posted: 2015-07-17
Enrollment: 96
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Athletes referred for exercise tests

Brief summary: Define responses to exercise on both arterial bruits and oxymetry in patients referred for suspected endofibrosis.

Detailed description: Recording of oxymetry during exercise and recovery. Recording of vascular bruits at rest ajnd post exercise.

Eligibility criteria: Inclusion Criteria:

Referred for exercise test -

Exclusion Criteria:

None

-

Primary outcomes:
measure: Caracteristics of sound
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Angers
country: France
facility: Centre hospitalier universitaire
Study officials:
affiliation: University Hopistal Angers, France
name: Antoine BRUNEAU, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04924894: Determinants of Obtaining Covid Vaccination Among Health Care Workers
Official title: Determinants of Obtaining COVID-19 Vaccination Among Health Care Workers Accessible to Free COVID-19 Vaccination: a Cross Sectional Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: COVID-19 Vaccination
Keywords: COVID-19, Vaccine, acceptance, attitude
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2021-06-14
Enrollment: 350
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: All healthcare workers in Assiut university hospitals how are eligible for COVID-19 vaccination and the vaccine is freely offered to them

Brief summary: Despite the global preventive efforts (physical distancing, face, mask, travel constraints, and quarantine) to contain the infection, COVID-19 is continuing with its devastating consequences on health, life, and economics. The world's hopes are attached to a successful preventive measure that is the vaccination which has proved its capability to stop infections and save lives over the years. World Health Organization (WHO) declared vaccination hesitancy as one of the top 10 obstacles for global health. Multicentric study involved Arab countries measure hesitancy of HCWs toward vaccine, it reported the highest rates of hesitancy were among participants from the western regions of the Arab world (Egypt, Morocco, Tunisia, and Algeria). This study aims to evaluate the attitude and the determinants of this attitude of HCWs towards receiving or refusing to have their first dose of vaccination.


Eligibility criteria: Inclusion Criteria:

* All staff how are working in AUH and offered to receive the first dose of AstraZeneca \& Sino pharm vaccine.

Exclusion Criteria:

* Those who are not eligible to receive the vaccine
* Those who are not freely offered to receive the vaccine

Primary outcomes:
measure: The rate of acceptance among HCWs who offered COVID-19 vaccine
timeFrame: baseline
Secondary outcomes:
measure: 1. Reasons for acceptance 2. Reasons for refusal 1. Reasons for acceptance 2. Reasons for refusal the response for COVID-19 vaccination acceptance or refusal
timeFrame: baseline
Other outcomes:
Locations:
Study officials:
References:
citation: Qunaibi E, Basheti I, Soudy M, Sultan I. Hesitancy of Arab Healthcare Workers towards COVID-19 Vaccination: A Large-Scale Multinational Study. Vaccines (Basel). 2021 May 2;9(5):446. doi: 10.3390/vaccines9050446.
citation: Pogue K, Jensen JL, Stancil CK, Ferguson DG, Hughes SJ, Mello EJ, Burgess R, Berges BK, Quaye A, Poole BD. Influences on Attitudes Regarding Potential COVID-19 Vaccination in the United States. Vaccines (Basel). 2020 Oct 3;8(4):582. doi: 10.3390/vaccines8040582.
Clinical trial NCT05089994: Comparison of Two Approaches of Quadratus Lumborum Block for Post-operative Analgesia in Radical Cystectomy
Official title: Comparison of Two Approaches of Quadratus Lumborum Block for Post-operative Analgesia in Radical Cystectomy: Prospective-randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Quadratus Lumborum Block
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2021-10-22
Enrollment: 60
Sex: ALL
Minimum age (years): 40
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare the postoperative analgesic effect of two ultrasound guided approaches of quadratus lumborum block (QLB) (anterior and intramuscular) for radical cystectomy.

Detailed description: The quadratus lumborum block (QLB) is one of the abdominal wall block techniques used to anesthetize thoracolumbar nerves . The QLB technique was described initially by Blanco et al. in 2007 (not published), then reported initially by Kadam in 2013. Since then, QLB has evolved with the development of the ultrasound-guided nerve block. To date, several randomized controlled trials have reported effective postoperative analgesia, with non-intramuscular QLB for cesarean sections, laparoscopic gynecologic surgery and hip hemiarthroplasty .

The intramuscular QLB (QLBi) technique was first reported by. This approach is different from others in tubouchi for QLB; although the injection target sites of the other approaches are planes around the quadratus lumborum muscle, the intramuscular approach penetrates the fascia of the quadratus lumborum muscle, where local anesthetics are injected. Therefore, QLBi is relatively easier to perform compared with other QLB approaches.

The incidence of urinary bladder cancer in the Middle East and Africa is greater in areas with high rather than low SH prevalence.

Eligibility criteria: Inclusion Criteria:

* Age: 40-70years.

  * BMI: 20-30 kg.m2
  * Sex: both males and females.
  * American Society of Anesthesiologists (ASA )physical status: I-III.
  * Operation: radical cystectomy

Exclusion Criteria:

* • Patient's refusal to participate in the study.

  * known allergy to local anesthesia (LA),
  * coagulopathy or thrombocytopenia,
  * body mass index (BMI) above 30 kg .m 2, and infection at site of injection.
  * Chronic pain syndromes,
  * Prolonged opioid medication,
  * Patients on regular use of analgesic or who received analgesic 24 h before surgery

Primary outcomes:
measure: Evaluate the first call for rescue analgesia
timeFrame: 24hours after recovery From anesthesia
Secondary outcomes:
measure: Total doses of morphine required
timeFrame: 24hours after recovery from anesthesia
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assuit university urology hospital
Study officials:
References:
Clinical trial NCT06989294: Effect of Lean Leadership Training Program on Head Nurses' Lean Performance and Staff Nurses' Workplace Safety at Mansoura Children Hospital
Official title: Effect of Lean Leadership Training Program on Head Nurses' Lean Performance and Staff Nurses' Workplace Safety at Mansoura Children Hospital
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Safety Issues
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2025-05-25
Enrollment: 200
Sex: ALL
Minimum age (years): 22
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Effect of Lean Leadership Training Program on Head Nurses' Lean Performance and Staff Nurses' Workplace Safety at Mansoura Children Hospital

Detailed description: Many global healthcare challenges, such as infections, preventable errors, growing healthcare costs, and changing patient expectations, have a negative impact on health outcomes. Lean management provides a solution to these problems by reducing costs and eliminating waste . So, implementation of lean practices improves staff performance, adapt to new competitors, and foster flexibility. They are beneficial for economic growth. Research shows that lean practices improve knowledge and skills of head nurses, improve environmental quality, and create a safer and more productive work environment . This study will provide more focus on the value of lean leadership as a new approach to be implemented in Egyptian hospitals to improve leader's competencies, capacity, and skills in determining wastes in care processes by using lean tools and for continuous improvement. Also, it will help in enhancing workplace safety and to provide safe and appropriate care for patient which result in improving health care system as a general. Hence the present study aims to evaluate the effect of a lean leadership training program on workplace safety.

Eligibility criteria: Inclusion Criteria:

* Agree to participate in the study.
* Head nurses have at least one year of job experience.

Exclusion Criteria:

* Agree to involve in the study. - Staff nurses have at least one year of job experience in the current job

Primary outcomes:
measure: Staff Nurses' perception about work environment safety as assessed by Practice Environment Scale of the Nursing Work Index (PES - NWI
timeFrame: from start to finish, up to three month
Secondary outcomes:
Other outcomes:
Locations:
city: Mansoura University
country: Egypt
facility: Mansoura University Children Hospital
Study officials:
References:
citation: Alshyyab, M. A., FitzGerald, G., Ababneh, E. Y., Zghool, A. W., & Albsoul, R. A. (2023). Nurses' perceptions regarding the impact of teamwork on patient safety culture in the operating room: A qualitative study. Perioperative Care and Operating Room Management, 33, 100345.
Clinical trial NCT01226160: Pilot Randomised Controlled Trial of Posturing Following Surgery for Full-thickness Macular Hole
Official title: Pilot Randomised Controlled Trial of Posturing Following Surgery for Full-thickness Macular Hole
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Full Thickness Macular Hole
Lead sponsor: Moorfields Eye Hospital NHS Foundation Trust
Sponsor class: OTHER
First posted: 2010-10-22
Enrollment: 30
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a pilot randomised controlled trial (RCT) to investigate the effect of postoperative face-down positioning on the outcome of macular hole surgery.


Eligibility criteria: Inclusion Criteria:

* full thickness macular hole
* \>16 years old

Exclusion Criteria:

* any history of previous intraocular surgery (including cataract surgery)
* history of ocular trauma
* history of visual loss greater than 1 year

Primary outcomes:
measure: Anatomical closure of the macula hole assessed 6 weeks following surgery by ocular coherence tomography.
timeFrame: 6 weeks
Secondary outcomes:
measure: Visual acuity assessed 6 weeks following surgery by Snellen charts.
timeFrame: 6 weeks
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: Moorfileld's Eye Hospital
Study officials:
References:
Clinical trial NCT02013960: Misoprostol vs. Sublingual Misoprostol and Laminaria For Second Trimester Termination of Pregnancy
Official title: Comparison Between Sublingual Misoprostol vs. Sublingual Misoprostol and Laminaria For Second Trimester Termination of Pregnancy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Other Abortion
Lead sponsor: Rambam Health Care Campus
Sponsor class: OTHER
First posted: 2013-12-17
Enrollment: 100
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: 1. Comparison between the duration of time from the beginning of cervical preparation until abortion, between sublingual misoprostol and the combination of sublingual misoprostol with laminaria for second trimester medical termination of pregnancy (TOP).
2. Comparison between the adverse event rate following Sublingual misoprostol only vs. Sublingual misoprostol and laminaria given for pregnancy termination.
3. Comparison between the levels of satisfaction rate of women who underwent pregnancy termination with sublingual misoprostol vs. sublingual misoprostol with laminaria.

Detailed description: A prospective randomized control trial; 50 women undergoing pregnancy termination in the second trimester (14-28 weeks)in each group.

Following receiving an ethical approval by the local institutional review board (IRB), committee, consecutively all women in between 14 weeks to 28 weeks; that have a reason for termination of pregnancy like: intrauterine fetal death or medical or genetic indications for termination of pregnancy or socioeconomic termination of pregnancy will be offered to take part in the study. If eligible according to the inclusion and exclusion criteria, women will be asked to sign a consent form.

All participants will undergo blood exams (CBC, Prothrombin time, Partial thromboplastin time , and BLOOD TYPING) and ultrasound exam for Confirmation of diagnosis as routinely indicated for missed abortion at our department

Eligibility criteria: Inclusion Criteria:

Second trimester pregnancy No evidence of chorioamnionitis

Exclusion Criteria:

Allergy to misoprostol. Evidence for infection. Asthma

Primary outcomes:
measure: Duration of time until pregnancy termination
timeFrame: Average time 12 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Haifa
country: Israel
facility: Rambam Health Campus
Study officials:
affiliation: Rambam Health Care Campus
name: Nibal Awad, MD
role: STUDY_CHAIR
References:
Clinical trial NCT05158660: Assessment of Intracerebral Hematoma
Official title: Assessment of Intracerebral Hematoma Using Transcranial Duplex _ Hospital Based Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Intracerebral Hematoma
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2021-12-15
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The study will assess acute intracerebral hematoma expansion within the first 48 hours from the onset using transcranial duplex sonography in patients who have acute intracerebral hematoma , and will also assess the correlation between the transcranial duplex sonography measurements and the clinical outcome of these patients .


Eligibility criteria: Inclusion Criteria:

1. first ever non traumatic supratentorial primary intracerebral haemorrhage on non contrast CT brain
2. admitted within 24 hours of symptom onset

Exclusion Criteria:

1. blood diseases, decompansated hepatic or renal impairment, or encephalopathy caused by electrolyte disturbance
2. on anticoagulant treatment
3. if devolped major complications during hospitalization ( e.g sever chest infection, hypoxia, or deep venous thrombosis )
4. comorbid neurological or psychiatric disorders

Primary outcomes:
measure: change from baseline in volume of intracerebral hematoma
timeFrame: at baseline, then 24 hour after the baseline, and finally 48 hours after the baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01698060: Immunogenicity of ND1.1 by Delivery Directly to the Ileum
Official title: An Open Label Phase I Substudy to Evaluate the Safety and Ability to Enhance Immunogenicity of ND1.1 by Delivery Directly to the Ileum Using the InteliSite® Companion Capsule in Healthy Adult Males
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Avian Influenza
Keywords: Prevention of Avian Influenza
Lead sponsor: Vaxart
Sponsor class: INDUSTRY
First posted: 2012-10-02
Enrollment: 12
Sex: MALE
Minimum age (years): 18
Maximum age (years): 49
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The purpose of the study is to determine the safety and tolerability of ND1.1, an adjuvanted adenoviral-based avian influenza vaccine, when delivery is targeted to the ileum, using a radio controlled capsule. The secondary objective is to evaluate the immune response (cellular and humoral) of two doses of ND1.1 oral vaccine.


Eligibility criteria: Inclusion Criteria:

* Able and willing to complete informed consent
* Healthy, as established by medical history, physical exam, and laboratory assessments
* Has normal bowel movements
* Willing to abstain from caffeine and xanthine containing substances for 24 hours before procedure until after discharge

Exclusion Criteria:

* Ability to donate up to 550 ml of blood over several months
* Exposure to any investigational drug or vaccine 8 weeks prior to study
* Has traveled to Asia within 8 weeks of enrollment
* Abnormal ECG findings
* History of irritable bowl or any other inflammatory gastrointestinal disorder
* Any individual with increased risk for bowl obstruction
* Radiation exposure above target values 50 mSv within the past 30 days or a cumulative dose above 150 mSv in the past 12 months
* History of substance abuse
* Subject unwilling to use an approved method of contraception during study and for 2 months after study
* Positive for HCV, HIV, or HBV
* Presence of an implantable device that is sensitive to radio frequencies (e.g. pacemakers)
* History of an autoimmune disorder, or an immunosuppressive disorder
* Stool sample with occult blood at baseline
* Any other medical, psychiatric, social condition, or occupation, in the judgement of the investigator, is a contraindication to the compliance of the protocol or informed consent

Primary outcomes:
measure: Safety
timeFrame: 1 year
Secondary outcomes:
measure: Immunogenicity
timeFrame: 1 year
Other outcomes:
Locations:
city: Lexington
country: United States
facility: Scintipharma
state: Kentucky
Study officials:
affiliation: Vaxart, Inc.
name: David Liebowitz, MD, PhD
role: STUDY_DIRECTOR
References: