Clinical trial NCT06398704: Investigation of Inspiratory Muscle Strength and Cardiorespiratory Fitness in Sarcopenic Individuals
Official title: Investigation of the Effects of Sarcopenia and Dynapenia on Inspiratory Muscle Strength and Cardiorespiratory Fitness in Geriatric Individuals
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Geriatric Individuals
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2024-05-03
Enrollment: 75
Sex: ALL
Minimum age (years): 65
Maximum age (years): 85
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Geriatric Individuals

Brief summary: The aim of our study is to examine the effects of sarcopenia and dynapenia on inspiratory muscle strength and cardiorespiratory fitness in geriatric individuals.

Detailed description: Within the scope of the study, anterior thigh thicknesses of geriatric individuals will be evaluated by ultrasonography and individuals will be divided into 3 groups as dynapenic, sarcopenic and normal according to the ISarcoPRM algorithm, using the STAR method and Hand-grip. The Powerbreathe K5 device will be used to evaluate the inspiratory muscle strength of geriatric individuals in both groups, and the 2-minute step test will be used to evaluate cardiorespiratory fitness. The study will be carried out with 100 geriatric individuals. As a result of the study, first the inspiratory muscle strength and cardiorespiratory fitness of sarcopenic, dynapenic and non-sarcopenic groups will be compared. Afterwards, the relationship between anterior thigh thickness and inspiratory muscle strength of all geriatric individuals participating in the study will be examined.

Eligibility criteria: Inclusion Criteria:

* Getting a score between 24 and 30 on the Mini Mental State Assessment
* Ability to stand without assistance for at least 90 seconds

Exclusion Criteria:

* Inability to communicate verbally
* Using a walking aid
* Older adults with severe visual impairment, neurological disorders, and/or congestive heart failure
* Older adults for whom exercise is not recommended

Primary outcomes:
measure: Ultrasonography Evaluation
timeFrame: Baseline
measure: Evaluation of Inspiratory Muscle Strength
timeFrame: Baseline
measure: 2 Minute Step Test:
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Atılım University
Study officials:
affiliation: Atılım University
name: Süleyman Korkusuz, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Baskent University
name: Özlem Yürük, Prof.Dr
role: STUDY_CHAIR
affiliation: Hacettepe University
name: Büşra Seçkinoğulları Korkusuz, MSc
role: STUDY_CHAIR
affiliation: European University of Lefke
name: Ferdi Yavuz, Assoc.Prof.
role: STUDY_CHAIR
affiliation: Atılım University
name: Hülya Arıkan, Prof.Dr.
role: STUDY_CHAIR
References:
citation: Ohara DG, Pegorari MS, Oliveira Dos Santos NL, de Fatima Ribeiro Silva C, Monteiro RL, Matos AP, Jamami M. Respiratory Muscle Strength as a Discriminator of Sarcopenia in Community-Dwelling Elderly: A Cross-Sectional Study. J Nutr Health Aging. 2018;22(8):952-958. doi: 10.1007/s12603-018-1079-4.
citation: Sawaya Y, Shiba T, Ishizaka M, Hirose T, Sato R, Kubo A, Urano T. Sarcopenia is not associated with inspiratory muscle strength but with expiratory muscle strength among older adults requiring long-term care/support. PeerJ. 2022 Feb 17;10:e12958. doi: 10.7717/peerj.12958. eCollection 2022.
citation: Kara M, Kaymak B, Frontera W, Ata AM, Ricci V, Ekiz T, Chang KV, Han DS, Michail X, Quittan M, Lim JY, Bean JF, Franchignoni F, Ozcakar L. Diagnosing sarcopenia: Functional perspectives and a new algorithm from the ISarcoPRM. J Rehabil Med. 2021 Jun 21;53(6):jrm00209. doi: 10.2340/16501977-2851.
citation: Kara M, Kaymak B, Ata AM, Ozkal O, Kara O, Baki A, Sengul Aycicek G, Topuz S, Karahan S, Soylu AR, Cakir B, Halil M, Ozcakar L. STAR-Sonographic Thigh Adjustment Ratio: A Golden Formula for the Diagnosis of Sarcopenia. Am J Phys Med Rehabil. 2020 Oct;99(10):902-908. doi: 10.1097/PHM.0000000000001439.