Clinical trial NCT00849667: Efficacy and Safety of Farletuzumab (MORAb-003) in Combination With Carboplatin and Taxane in Participants With Platinum-sensitive Ovarian Cancer in First Relapse
Official title: A Randomized, Double-blind, Placebo-Controlled, Phase 3 Study to Assess the Efficacy and Safety of Weekly Farletuzumab (MORAb-003) in Combination With Carboplatin and Taxane in Subjects With Platinum-sensitive Ovarian Cancer in First Relapse
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Ovarian Cancer
Keywords: ovarian cancer
relapsed ovarian cancer
Platinum-sensitive Ovarian Cancer
Lead sponsor: Morphotek
Sponsor class: INDUSTRY
Collaborators: name: Eisai Europe Ltd. (United Kingdom)
First posted: 2009-02-24
Enrollment: 1100
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This research is being done to find out if Carboplatin and Taxane works better alone or when given with an experimental drug called MORAb-003(farletuzumab) in subjects with first platinum sensitive relapsed ovarian cancer.


Eligibility criteria: Inclusion Criteria:

* A histologically or cytologically confirmed diagnosis of non-mucinous epithelial ovarian cancer including primary peritoneal or fallopian tube malignancies
* Must have measurable disease by CT or MRI scan
* Must have relapsed radiologically with a randomization date within ≥6 and \< 24 months of completion of first-line platinum chemotherapy
* Have been treated with debulking surgery and first-line platinum and taxane based chemotherapy.
* Prior bevacizumbab maintenance is allowed. The last dose of bevacizumab must have been at least 30 days before study Day 1. No cytotoxic maintenance therapy (e.g. taxane) or cancer vaccine therapy is allowed.
* Must be a candidate for carboplatin and taxane therapy
* Neurologic function: neuropathy (sensory and motor) ≤CTCAE Grade 1

Exclusion Criteria:

* Subjects who never responded to first-line platinum-based therapy or whose first relapse occurs \<6 months or \>24 months from the last platinum therapy
* Subjects who have received other therapy to treat their ovarian cancer since relapse
* Known central nervous system (CNS) tumor involvement
* Evidence of other active invasive malignancy requiring treatment in the past 5 years
* Known allergic reaction to a prior monoclonal antibody therapy or have any documented HAHA
* Previous treatment with MORAb-003 (farletuzumab)
* Clinical contraindications to use of a taxane

Primary outcomes:
measure: Progression-free Survival (PFS)
timeFrame: From the date of randomization to the date of first documentation of disease progression, or date of death, whichever occurred first (up to 44 months)
Secondary outcomes:
measure: Overall Survival (OS)
timeFrame: From the date of randomization until date of death from any cause, or study termination by sponsor, whichever came first (up to 48 months)
measure: Cancer Antigen-125 (CA-125) Progression-Free Survival
timeFrame: From the date of randomization to the date of first documentation of disease progression, or date of death, whichever occurred first (up to 44 months)
measure: Progression-Free Survival Based on Gynecologic Cancer InterGroup (GCIG) Criteria
timeFrame: From the date of randomization to the date of first documentation of disease progression, or date of death, whichever occurred first (up to 44 months)
measure: Percentage of Participants With Length of Second Remission Greater Than First Remission
timeFrame: From the date of last dose of platinum-based chemotherapy to date of relapse and date of last dose of platinum-based chemotherapy to first observation of progression (up to 48 months)
measure: Percentage of Participants With Objective Response
timeFrame: From the date of randomization to the date of first documentation of disease progression, or date of death, whichever occurred first (up to 48 months)
measure: Duration of Tumor Response
timeFrame: From the first date of confirmed objective response (CR or PR) to first date of progression or death due to any cause (up to 48 months)
measure: Time to Tumor Response (TTR)
timeFrame: From the date of randomization to first documentation of objective response (up to 48 months)
measure: Percentage of Participants With Serologic Response (SR)
timeFrame: Up to 48 months
measure: Duration of 50% Serologic Response
timeFrame: From the first date of documentation of response to first documentation of serologic progression or death due to any cause (up to 48 months)
measure: Time to 50% Serologic Response (TSR)
timeFrame: From the date of randomization to first documentation of 50% SR (up to 48 months)
measure: Percentage of Participants With Clinical Benefit
timeFrame: Up to 48 months
measure: Cmax: Maximum Observed Plasma Concentration of Total Carboplatin and Total Paclitaxel
timeFrame: Cycle 2 Week 1 Day 1: 0-45 hours post-dose (cycle length=21 days)
measure: Tmax: Time to Reach the Maximum Plasma Concentration (Cmax) of Total Carboplatin and Total Paclitaxel
timeFrame: Cycle 2 Week 1 Day 1: 0-45 hours post-dose (cycle length=21 days)
measure: AUC (0-inf): Area Under the Concentration-time Curve From Zero (Pre-dose) Extrapolated to Infinite Time of Total Carboplatin and Total Paclitaxel
timeFrame: Cycle 2 Week 1 Day 1: 0-45 hours post-dose (cycle length=21 days)
measure: T1/2: Terminal Half-life of Total Carboplatin and Total Paclitaxel
timeFrame: Cycle 2 Week 1 Day 1: 0-45 hours post-dose (cycle length=21 days)
measure: CL: Clearance of Total Carboplatin and Total Paclitaxel
timeFrame: Cycle 2 Week 1 Day 1: 0-45 hours post-dose (cycle length=21 days)
measure: Vd: Volume of Distribution of Total Carboplatin and Total Paclitaxel
timeFrame: Cycle 2 Week 1 Day 1: 0-45 hours post-dose (cycle length=21 days)
measure: Mean Functional Assessment of Cancer Therapy-Ovarian Treatment Outcome Index (FACT-O TOI) Scores
timeFrame: Cycle 3, Cycle 6, Cycle 12 (each cycle length=21 days)
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University Of Alabama At Birmingham
state: Alabama
city: Huntsville
country: United States
facility: Oncology Specialties, PC
state: Alabama
city: Phoenix
country: United States
facility: Arizona Hematology & Oncology Associates
state: Arizona
city: Phoenix
country: United States
facility: St. Joseph's Hospital, Barrow Neurology Clinics
state: Arizona
city: Tucson
country: United States
facility: Arizona Oncology Associates
state: Arizona
city: Tucson
country: United States
facility: Arizona Cancer Center
state: Arizona
city: Burbank
country: United States
facility: Providence St. Joseph Medical Center
state: California
city: Greenbrae
country: United States
facility: California Cancer Care, Inc.
state: California
city: La Jolla
country: United States
facility: University of California San Diego
state: California
city: Los Angeles
country: United States
facility: University of California Los Angeles Medical Center
state: California
city: Newport Beach
country: United States
facility: Gynecologic Oncology Associates
state: California
city: Sacramento
country: United States
facility: University of California Davis Cancer Center
state: California
city: Stanford
country: United States
facility: Stanford University
state: California
city: Aurora
country: United States
facility: University of Colorado
state: Colorado
city: Colorado Springs
country: United States
facility: Catholic Health Initiatives
state: Colorado
city: Denver
country: United States
facility: Denver Health and Hospital Authority
state: Colorado
city: Stamford
country: United States
facility: Hematology Oncology P.C.
state: Connecticut
city: Washington
country: United States
facility: Washington Hospital Center
state: District of Columbia
city: Boynton Beach
country: United States
facility: Palm Beach Institute of Hematology and Oncology
state: Florida
city: Boynton Beach
country: United States
facility: University Cancer Institute
state: Florida
city: Gainesville
country: United States
facility: Gainsville Hematology Oncology Associates
state: Florida
city: Jacksonville
country: United States
facility: Baptist Cancer Institute
state: Florida
city: Jupiter
country: United States
facility: Jupiter Medical center Physician's Group
state: Florida
city: Lake Worth
country: United States
facility: Hematology/Oncology Associates
state: Florida
city: Lakeland
country: United States
facility: Lakeland Regional Cancer Center
state: Florida
city: Orlando
country: United States
facility: Florida Hospital
state: Florida
city: Saint Petersburg
country: United States
facility: Gulfcoast Oncology
state: Florida
city: Sarasota
country: United States
facility: Sarasota Memorial Healthcare System
state: Florida
city: Tamarac
country: United States
facility: Oncology-Hematology Associates of W. Broward P.A.
state: Florida
city: West Palm Beach
country: United States
facility: Palm Beach Cancer Institute
state: Florida
city: Augusta
country: United States
facility: Medical College of Georgia
state: Georgia
city: Savannah
country: United States
facility: Memorial Health University Medical Center
state: Georgia
city: Honolulu
country: United States
facility: Kaiser Permanente - Moanalua Medical Center
state: Hawaii
city: Honolulu
country: United States
facility: Kapi'olani Medical Center for Women and Children
state: Hawaii
city: Galesburg
country: United States
facility: Medical & Surgical Specialists, LLC
state: Illinois
city: Harvey
country: United States
facility: Ingalls Memorial Hospital
state: Illinois
city: Maywood
country: United States
facility: Loyola University Chicago
state: Illinois
city: Skokie
country: United States
facility: Midwest Cancer Research Group
state: Illinois
city: Winfield
country: United States
facility: Central DuPage Hospital
state: Illinois
city: Indianapolis
country: United States
facility: St. Francis Hospital & Health Centers
state: Indiana
city: Indianapolis
country: United States
facility: St. Vincent Gynecologic Oncology
state: Indiana
city: Lexington
country: United States
facility: Central Baptist Hospital
state: Kentucky
city: Louisville
country: United States
facility: University of Louisville
state: Kentucky
city: Louisville
country: United States
facility: Norton Healthcare
state: Kentucky
city: Metairie
country: United States
facility: Hematology & Oncology Specialists
state: Louisiana
city: Baltimore
country: United States
facility: Mercy Medical Center
state: Maryland
city: Baltimore
country: United States
facility: Greater Baltimore Medical Center
state: Maryland
city: Baltimore
country: United States
facility: John Hopkins University
state: Maryland
city: Baltimore
country: United States
facility: Weinberg Cancer Institute at Franklin Square
state: Maryland
city: Bethesda
country: United States
facility: Center for Cancer and Blood Disorders
state: Maryland
city: Frederick
country: United States
facility: Frederick Memorial Hospital
state: Maryland
city: Detroit
country: United States
facility: Barbara Ann Kamanos Cancer Center
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Health System
state: Michigan
city: Grand Rapids
country: United States
facility: Saint Mary's Health Care
state: Michigan
city: Lansing
country: United States
facility: Sparrow Regional Cancer Center
state: Michigan
city: Saint Louis Park
country: United States
facility: Park Nicollet Institute
state: Minnesota
city: Grand Island
country: United States
facility: Saint Francis Memorial Health Center
state: Nebraska
city: Kearney
country: United States
facility: Good Samaritan Hospital Cancer Center
state: Nebraska
city: Camden
country: United States
facility: The Center for Cancer and Hematologic Disease
state: New Jersey
city: Denville
country: United States
facility: Hematology-Oncolgy Associates of NNJ-PA
state: New Jersey
city: Hackensack
country: United States
facility: John Theurer Cancer Center at Hackensack University MC
state: New Jersey
city: Morristown
country: United States
facility: Morristown Memorial Hospital
state: New Jersey
city: Voorhees
country: United States
facility: Cooper Cancer Institute
state: New Jersey
city: Albuquerque
country: United States
facility: University of New Mexico Cancer Center
state: New Mexico
city: Buffalo
country: United States
facility: Roswell Park Cancer Institute
state: New York
city: Lake Success
country: United States
facility: Arena Oncology Associates
state: New York
city: New York
country: United States
facility: Columbia University Medical Center
state: New York
city: Syracuse
country: United States
facility: SUNY Upstate Medical University
state: New York
city: Charlotte
country: United States
facility: Carolinas Medical Center
state: North Carolina
city: Charlotte
country: United States
facility: Presbyterian Hospital
state: North Carolina
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
city: Winston-Salem
country: United States
facility: Piedmont Hematology & Oncology
state: North Carolina
city: Cincinnati
country: United States
facility: Catholic Health Initiatives
state: Ohio
city: Cleveland
country: United States
facility: University Hospitals of Cleveland
state: Ohio
city: Cleveland
country: United States
facility: MetroHealth Medical Center
state: Ohio
city: Dayton
country: United States
facility: Miami Valley Hospital
state: Ohio
city: Kettering
country: United States
facility: Kettering Medical Center
state: Ohio
city: Middletown
country: United States
facility: Signal Point Clinical Research Center, LLC
state: Ohio
city: Tulsa
country: United States
facility: Cancer Care Associates
state: Oklahoma
city: Portland
country: United States
facility: Providence Oncology & Hematology Care
state: Oregon
city: Portland
country: United States
facility: Kaiser Permanente Northwest
state: Oregon
city: Portland
country: United States
facility: Oregon Health & Science University
state: Oregon
city: Springfield
country: United States
facility: Willamette Valley Cancer Center
state: Oregon
city: Abington
country: United States
facility: Abington Memorial Hospital
state: Pennsylvania
city: Bethlehem
country: United States
facility: St. Luke's Hospital
state: Pennsylvania
city: DuBois
country: United States
facility: Oncology Hematology Associates
state: Pennsylvania
city: Gettysburg
country: United States
facility: Gettysburg Cancer Center
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Magee-Womens Hospital of UPMC
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Western Pennsylvania Hospital
state: Pennsylvania
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
city: Chattanooga
country: United States
facility: Chattanooga's Program in Women's Oncology
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center
state: Tennessee
city: Austin
country: United States
facility: Texas Oncology, PA
state: Texas
city: Bedford
country: United States
facility: Texas Oncology, P.A.
state: Texas
city: Dallas
country: United States
facility: Texas Oncology, PA
state: Texas
city: Dallas
country: United States
facility: Baylor Sammons Cancer Center
state: Texas
city: Harlingen
country: United States
facility: International Beneficence Clinical Research, L.L.C.
state: Texas
city: Houston
country: United States
facility: University of Texas Health Science Center at Houston Medical School
state: Texas
city: San Antonio
country: United States
facility: South Texas Oncology and Hematology, PA
state: Texas
city: Temple
country: United States
facility: Scott and White Memorial Hospital
state: Texas
city: Wichita Falls
country: United States
facility: US Oncology Research
state: Texas
city: Ogden
country: United States
facility: Northern Utah Associates
state: Utah
city: Salt Lake City
country: United States
facility: Utah Cancer Specialists
state: Utah
city: Annandale
country: United States
facility: Northern Virginia Pelvic Surgery Associates
state: Virginia
city: Newport News
country: United States
facility: Peninsula Cancer Institute - Riverside Gynecology Oncology
state: Virginia
city: Bremerton
country: United States
facility: Harrison Bremerton Hematology and Oncology
state: Washington
city: Everett
country: United States
facility: Providence Everett Medical Center
state: Washington
city: Spokane
country: United States
facility: Cancer Care Northwest-South
state: Washington
city: Vancouver
country: United States
facility: Northwest Cancer Specialists, PC
state: Washington
city: West Allis
country: United States
facility: Aurora Health Care
state: Wisconsin
city: Buenos Aires
country: Argentina
facility: Hospital Zonal Especializado en Oncología de Lanús
city: Buenos Aries
country: Argentina
facility: Consultorios Medicos Privados SA
city: Caba
country: Argentina
facility: Fundación Sanatorio Güemes
city: Códoba
country: Argentina
facility: Clinica Universitaria Reina Fabiola
city: La Plata
country: Argentina
facility: Instituto Medico Platense
city: La Rioja
country: Argentina
facility: Centro Oncologico Riojano Integral (CORI)
city: Loma Hermosa
country: Argentina
facility: Hospital Bocalandro
city: Mar Del Plata
country: Argentina
facility: Centro Oncologico Integral
city: Quilmes
country: Argentina
facility: CER Instituto Medico
city: San Miguel de Tucuman
country: Argentina
facility: Centro Médico San Roque
city: San Salvador de Jujuy
country: Argentina
facility: Centro Medico de Alta Complejidad Cemac
city: Santa Fe
country: Argentina
facility: ISIS Centro Especializado de LUCE SA
city: Tweed Heads
country: Australia
facility: Tweed Hospital
state: New South Wales
city: Westmead
country: Australia
facility: Westmead Hospital
state: New South Wales
city: Herston
country: Australia
facility: The Royal Brisbane and Women's Hospital
state: Queensland
city: South Brisbane
country: Australia
facility: Mater Adult Hospital
state: Queensland
city: North Adelaide
country: Australia
facility: North Adelaide Oncology Clinical Trials
state: South Australia
city: Nedlands
country: Australia
facility: Sir Charles Gairdner Hospital
state: Western Australia
city: Villach
country: Austria
facility: Landeskrankenhaus Villach
city: Wien
country: Austria
facility: Kaiser-Franz-Josef Spital
city: Wien
country: Austria
facility: Krankenhaus Wien-Hietzing
city: Bruxelles
country: Belgium
facility: Institut Jules Bordet
city: Bruxelles
country: Belgium
facility: Cliniques Universitaires Saint-Luc
city: Gent
country: Belgium
facility: UZ Gent
city: Kortrijk
country: Belgium
facility: AZ Groeninge - Campus Maria's Voorzienigheid
city: Leuven
country: Belgium
facility: UZ Leuven
city: Liège
country: Belgium
facility: CHU de Liège
city: Wilrijk
country: Belgium
facility: Sint-Augustinuskliniek
city: Barretos
country: Brazil
facility: Fundação Pio XII - Hospital de Câncer de Barretos
city: Caxias do Sul
country: Brazil
facility: Instituto de Pesquisas Clínicas para Estudos Multicêntricos
city: Curitiba
country: Brazil
facility: Santa Casa da Misericórdia de Curitiba
city: Fortaleza
country: Brazil
facility: Instituto do Câncer do Ceará - ICC
city: Goiania
country: Brazil
facility: Hosp. Araujo Jorge
city: Ijuí
country: Brazil
facility: Associação Hospital de Caridade Ijuí
city: Itajai
country: Brazil
facility: Clinica de Neoplasias Litoral
city: Jaú
country: Brazil
facility: Hospital Amaral Carvalho
city: Natal
country: Brazil
facility: Liga Norte-Riograndense Contra o Câncer
city: Porto Alegre
country: Brazil
facility: Irmandade Santa Casa de Misericórdia de Porto Alegre
city: Porto Alegre
country: Brazil
facility: Clínica de Oncologia de Porto Alegre S/S Ltda
city: Ribeirão Preto
country: Brazil
facility: Instituto Ribeirãopretano de Combate ao Câncer
city: Rio De Janeiro - RJ
country: Brazil
facility: INCA - Instituto Nacional do Câncer
city: Rio de Janeiro
country: Brazil
facility: Clínica Oncologistas Associados
city: Salvador
country: Brazil
facility: Hospital Santa Izabel - Santa Casa de Misericordia da Bahia
city: Salvador
country: Brazil
facility: Clínica AMO - Assistência Multidiciplinar em Oncologia
city: Santo André
country: Brazil
facility: Centro de Estudos de Oncologia da FMABC
city: Santo André
country: Brazil
facility: Saúde ABC Serviços Médicos Hospitalares Ltda
city: São Paulo
country: Brazil
facility: Instituto do Câncer Arnaldo Vieira de Carvalho
city: São Paulo
country: Brazil
facility: Certo Oncologia
city: São Paulo
country: Brazil
facility: Hospital Premier
city: Calgary
country: Canada
facility: Tom Baker Cancer Centre
state: Alberta
city: Kelowna
country: Canada
facility: Cancer Center For The Southern Interior
state: British Columbia
city: Surrey
country: Canada
facility: British Columbia Cancer Agency
state: British Columbia
city: Vancouver
country: Canada
facility: BCCA
state: British Columbia
city: Moncton
country: Canada
facility: The Moncton Hospital
state: New Brunswick
city: Ottawa
country: Canada
facility: Ottawa Hospital
state: Ontario
city: Santiago
country: Chile
facility: Instituto de Terapias Oncologicas
city: Temuco
country: Chile
facility: Instituto Clínico Oncológico del Sur
city: Viña del Mar
country: Chile
facility: Instituto Oncologico Ltda.
city: Angers Cedex 9
country: France
facility: Centre Régional de lutte contre le cancer Paul Papin
city: Le Coudray
country: France
facility: Centre Hospitalier Louis Pasteur
city: Marseille
country: France
facility: Institut Paoli Calmettes
city: Paris Cedex 10
country: France
facility: Hôpital Saint Louis
city: Reims
country: France
facility: Institut Jean Godinot - Centre de lutte contre le cancer
city: Berlin-Buch
country: Germany
facility: Helios Klinikum Berlin-Buch
city: Berlin
country: Germany
facility: Charité - Universitätsmedizin Berlin
city: Chemnitz
country: Germany
facility: Klinikum Chemnitz gGmbH
city: Düsseldorf
country: Germany
facility: Marien-Hospital Akademisches Lehrkrankenhaus
city: Ebersberg
country: Germany
facility: Frauenarztpraxis Dr. med. Gröll de Rivera
city: Essen
country: Germany
facility: Universitätsklinikum Essen
city: Frankfurt
country: Germany
facility: Krankenhaus Nordwest
city: Freiburg
country: Germany
facility: Universitätsklinikum Freiburg
city: Hamburg
country: Germany
facility: Kath. Marienkrankenhaus gGmbH
city: Heidelberg
country: Germany
facility: Universität Heidelberg
city: Karlsruhe
country: Germany
facility: St. Vincentius Kliniken Karlsruhe
city: Magdeburg
country: Germany
facility: Universitätsklinik Magdeburg
city: Mainz
country: Germany
facility: Universitätsmedizin der Johannes Gutenberg-Universität Mainz
city: München
country: Germany
facility: Klinikum der Universität München - Innenstadt
city: München
country: Germany
facility: Rotkreuzklinikum München
city: Rostock
country: Germany
facility: Klinikum Südstadt Rostock
city: Traunstein
country: Germany
facility: Klinikum Traunstein
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion
state: Crete
city: Athens
country: Greece
facility: Alexandra Hospital
city: Athens
country: Greece
facility: General Oncology Hospital Kifissias "Oi Agioi Anargyroi"
city: Patras
country: Greece
facility: University General Hospital of Patras
city: Thessaloniki
country: Greece
facility: Papageorgiou General Hospital
city: Pokfulam
country: Hong Kong
facility: Queen Mary Hospital
state: Islands
city: Tuen Mun
country: Hong Kong
facility: Tuen Mun Hospital
city: Budapest
country: Hungary
facility: Semmelweis Egyetem
city: Budapest
country: Hungary
facility: Semmelweis Egyetem
city: Gyor
country: Hungary
facility: Petz Aladár Megyei Oktató Kórház
city: Kecskemét
country: Hungary
facility: Bács-Kiskun Megyei Önkormányzat Kórháza
city: Miskolc
country: Hungary
facility: Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház
city: Szolnok
country: Hungary
facility: Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház-Rendelöintézet
city: Veszprém
country: Hungary
facility: Veszprém Megyei Önkormányzat Csolnoky Ferenc Kórház-Rendelöintézet
city: Gandhinagar
country: India
facility: Apollo Hospitals International Limited
state: Gujarat
city: Bangalore
country: India
facility: Kidwai Memorial Institute of Oncology
state: Karnataka
city: Bhopal
country: India
facility: Jawaharlal Nehru Cancer Hospital & Research Centre
state: Madhya Pradesh
city: Pune
country: India
facility: Jehangir, Clinical Development Centre
state: Maharashtra
city: Pune
country: India
facility: Ruby Hall Clinic
state: Maharashtra
city: Chennai
country: India
facility: Dr. Kamakshi Memorial Hospital
state: Tamil Nadu
city: Kolkata
country: India
facility: Chittaranjan National Cancer Institute
state: West Bengal
city: Bangalore
country: India
facility: M.S Ramaiah Medical College and Teaching Hospital Ethical Review Board
city: Cochin
country: India
facility: Amrita Institute of Medical Sciences and Research Centre
city: Hyderabaad
country: India
facility: MNJ Institute of Oncology and Regional Cancer Centre
city: Jaipur
country: India
facility: SK Soni Hospital
city: Jaipur
country: India
facility: Bhagwan Mahaveer Cancer Hospital and Research Centre
city: Kochi
country: India
facility: Lakeshore Hospital
city: Mumbai
country: India
facility: Tata Memorial Hospital
city: Nashik
country: India
facility: Shatabdi Superspeciality Hospital
city: Nasik
country: India
facility: Curie Manavata Cancer Centre
city: New Delhi
country: India
facility: All India Institute of Medical Sciences
city: Trivandrum
country: India
facility: Regional Cancer Centre
city: Haifa
country: Israel
facility: Rambam Medical Center
city: Haifa
country: Israel
facility: Linn Medical Center, Clalit Health Services
city: Holon
country: Israel
facility: Wolfson Centre
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
city: Jerusalem
country: Israel
facility: Hadassah University Hospital Ein Kerem
city: Kfar Saba
country: Israel
facility: Meir Medical Center
city: Petach Tikva
country: Israel
facility: Rabin Medical Center
city: Ramat-Gan
country: Israel
facility: The Chaim Sheba Medical Center
city: Rehovot
country: Israel
facility: Kaplan Medical Center
city: Zerifin
country: Israel
facility: Assaf Harofe Medical Center
city: Aviano
country: Italy
facility: Centro di Riferimento Oncologico
state: Pordenone
city: Alessandria
country: Italy
facility: Azienda Ospedaliera Santi Antonio, Biagio e Cesare Arrigo
city: Bologna
country: Italy
facility: Azienda Ospedaliero-Universitaria di Bologna - Policlinico S.Orsola-Malpighi
city: Brescia
country: Italy
facility: Istituto Ospedaliero Fondazione Poliambulanza
city: Campobasso
country: Italy
facility: Centro di Ricerca e Formazione ad Alta Tecnologia nelle Scienze Biomediche
city: Catania
country: Italy
facility: Azienda Ospedaliera Cannizzaro
city: Catania
country: Italy
facility: Humanitas Centro Catanese di Oncologia
city: Como
country: Italy
facility: Azienda Ospedaliera Sant'Anna
city: Faenza
country: Italy
facility: Ospedale di Faenza
city: Genova
country: Italy
facility: Azienda Ospedaliera Universitaria San Martino
city: Lecce
country: Italy
facility: Presidio Ospedaliero Vito Fazzi
city: Legnago
country: Italy
facility: Ospedale Mater Salutis ULSS 21 della regione Veneto
city: Meldola
country: Italy
facility: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori - IRST
city: Milano
country: Italy
facility: Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
city: Milano
country: Italy
facility: Fondazione Centro San Raffaele del Monte Tabor
city: Milano
country: Italy
facility: Istituto Nazionale dei Tumori
city: Milano
country: Italy
facility: Azienda Ospedaliera Niguarda Cà Granda
city: Napoli
country: Italy
facility: Istituto Nazionale per lo studio e la cura dei tumori "Fondazione Giovanni Pascale"
city: Negrar
country: Italy
facility: Ospedale Sacro Cuore Don Calabria
city: Padova
country: Italy
facility: Istituto Oncologico Veneto
city: Perugia
country: Italy
facility: Ospedale Santa Maria della Misericordia di Perugia
city: Ravenna
country: Italy
facility: Ospedale Santa Maria delle Croci
city: Reggio Emilia
country: Italy
facility: Arcispedale Santa Maria Nuova
city: Roma
country: Italy
facility: Azienda Policlinico Umberto I
city: Roma
country: Italy
facility: Policlinico Universitario "A. Gemelli"
city: Udine
country: Italy
facility: Azienda Ospedaliero-Universitaria di Udine
city: Akashi
country: Japan
city: Amagasaki
country: Japan
city: Chiba
country: Japan
city: Fukuoka
country: Japan
city: Hidaka
country: Japan
city: Hiroshima
country: Japan
city: Kagoshima
country: Japan
city: Kashiwa
country: Japan
city: Kawasaki
country: Japan
city: Koto-Ku
country: Japan
city: Kumamoto
country: Japan
city: Kure
country: Japan
city: Kurume
country: Japan
city: Matsuyama
country: Japan
city: Minato-Ku
country: Japan
city: Morioka
country: Japan
city: Nagoya
country: Japan
city: Nakano-Ku
country: Japan
city: Niigata
country: Japan
city: Okayama
country: Japan
city: Osakasayama
country: Japan
city: Osaka
country: Japan
city: Sapporo
country: Japan
city: Sendai
country: Japan
city: Shinjuku-Ku
country: Japan
city: Sunto-Gun
country: Japan
city: Tsukuba
country: Japan
city: Tsu
country: Japan
city: Yamagata
country: Japan
city: Yonago
country: Japan
city: Gyeonggi-do
country: Korea, Republic of
facility: National Cancer Center
city: In Cheon
country: Korea, Republic of
facility: Gachon University Gil Medical Center
city: Seoul
country: Korea, Republic of
facility: Cheil General Hospital & Women's Healthcare Center
city: Seoul
country: Korea, Republic of
facility: Seoul national univercity hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University College of Medicine
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Colima
country: Mexico
facility: Union Medica Quirurgica de Colima
city: Morelia
country: Mexico
facility: Triva Investigaciones Medicas Sociedad Anónima de Capital Variable
city: Veracruz
country: Mexico
facility: Hospital Regional de Veracruz
city: Amsterdam
country: Netherlands
facility: VU Medisch Centrum
city: Dordrecht
country: Netherlands
facility: Albert Schweitzer Ziekenhuis
city: Maastricht
country: Netherlands
facility: Academisch Ziekenhuis Maastricht
city: Sittard-Geleen
country: Netherlands
facility: Orbis Medisch Centrum
city: Cebu City
country: Philippines
facility: Perpetual Succour Hospital
state: Cebu
city: Cebu
country: Philippines
facility: Cebu Gynecologic Cancer Care Clinic
city: Manila
country: Philippines
facility: Manila Doctors Hospital
city: Pasay City
country: Philippines
facility: San Juan de Dios Hospital
city: Quezon City
country: Philippines
facility: St. Luke's Medical Center
city: Quezon City
country: Philippines
facility: National Kidney and Transplant Institute
city: Bialystok
country: Poland
facility: Bialostockie Centrum Onkologii
city: Gdansk
country: Poland
facility: Wojewodzkie Centrum Onkologii
city: Gliwice
country: Poland
facility: Centrum Onkologii, Instytut im. M. Sklodowskiej-Curie oddzial w Gliwicach
city: Lodz
country: Poland
facility: Wojewodzki Szpital Specjalistyczny im. M. Kopernika w Lodzi
city: Lublin
country: Poland
facility: Centrum Onkologii Ziemi Lubelskiej
city: Olsztyn
country: Poland
facility: Zaklad Opieki Zdrowotnej MSWiA z Warminsko-Mazurskim Centrum Onkologii
city: Olsztyn
country: Poland
facility: Olsztynski Osrodek Onkologiczny "Kopernik" Sp. z o.o.
city: Poznan
country: Poland
facility: Wielkopolskie Centrum Onkologii
city: Poznan
country: Poland
facility: Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w Pozna
city: Rybnik
country: Poland
facility: SPZOZ Wojewodzki Szpital Specjalistyczny nr 3
city: Szczecin
country: Poland
facility: Samodzielny Publiczny Szpital Kliniczny nr 2 PAM w Szczecinie
city: Warszawa
country: Poland
facility: Wojskowy Instytut Medyczny
city: Coimbra
country: Portugal
facility: Hospitais da Universidade de Coimbra
city: Coimbra
country: Portugal
facility: Instituto Português de Oncologia Francisco Gentil, Centro Regional de Oncologia de Coimbra, EPE
city: Lisboa
country: Portugal
facility: Instituto Portugues de Oncologia de Lisboa Francisco Gentil (IPOLFG, EPE)
city: Porto
country: Portugal
facility: Instituto Portugues de Oncologia do Porto Francisco Gentil (IPOPFG, EPE)
city: Porto
country: Portugal
facility: Hospital de São João
city: Kursk
country: Russian Federation
facility: Kursk Regional Oncology Centre
city: Moscow
country: Russian Federation
facility: Russian Oncology Research Center named after N.N. Blokhin
city: Moscow
country: Russian Federation
facility: Russian Oncology Research Center
city: Moscow
country: Russian Federation
facility: Moscow Research Oncology Institute n.a. P.A.Gertsen
city: Obninsk
country: Russian Federation
facility: Medical Radiology Research Center of RAMS
city: Ryazan
country: Russian Federation
facility: Ryazan Regional Clinical Oncology Dispensary
city: St. Petersburg
country: Russian Federation
facility: City Clinical Oncology Dispensary
city: Ufa
country: Russian Federation
facility: Republican Clinical Oncology Center of Bashkortostan Republic Ministry of Healthcare
city: Singapore
country: Singapore
facility: National University Hospital
city: Singapore
country: Singapore
facility: National Cancer Centre
city: Singapore
country: Singapore
facility: KK Women's and Children's Hospital
city: Córdoba
country: Spain
facility: Hospital Universitario Reina Sofia
state: Andalucía
city: Sevilla
country: Spain
facility: Hospital Virgen del Rocio
state: Andalucía
city: Palma de Mallorca
country: Spain
facility: Hospital Son Llatzer
state: Baleares
city: Barcelona
country: Spain
facility: Hospital Universitario Vall D'Hebron
state: Cataluna
city: Barcelona
country: Spain
facility: Hospital Clinic i Provincial
state: Cataluña
city: Mataró
country: Spain
facility: Hospital de Mataró
state: Cataluña
city: Sabadell
country: Spain
facility: Corporació Sanitaria Parc Taulí
state: Cataluña
city: Terrassa
country: Spain
facility: Hospital Mutua de Terrassa
state: Cataluña
city: Elche
country: Spain
facility: Hospital General Universitario de Elche
state: Comunidad Valenciana
city: Valencia
country: Spain
facility: Fundación Instituto Valenciano de Oncología
state: Comunidad Valenciana
city: Alcorcón
country: Spain
facility: Fundacion Hospital Alcorcon
state: Madrid, Communidad De
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañon
state: Madrid, Communidad De
city: Madrid
country: Spain
facility: Hospital Universitario Ramón y Cajal
state: Madrid, Communidad De
city: Madrid
country: Spain
facility: Hospital 12 de Octubre
state: Madrid, Communidad De
city: Madrid
country: Spain
facility: Hospital Clinico San Carlos
city: Zürich
country: Switzerland
facility: Universität Zürich
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hosptial
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Mackay Memorial Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taipei
country: Taiwan
facility: Tri-Service General Hospital
city: Taoyuan
country: Taiwan
facility: Chang Gung Memorial Hospital
city: Cherkasy
country: Ukraine
facility: Municipal Institution of Cherkasy Regional Counsil "Cherkasy Regional Oncology Dispensary"
city: Chernivtsi
country: Ukraine
facility: Chernivtsi Regional Clinical Oncology Dispansery
city: Kyiv
country: Ukraine
facility: Kiev City Oncology Hospital
city: Lutsk
country: Ukraine
facility: Volyn Regional Oncology Dispensary
city: Belfast
country: United Kingdom
facility: Belfast City Hospital
city: Cardiff
country: United Kingdom
facility: Velindre Hospital
city: Coventry
country: United Kingdom
facility: University Hospital Coventry
city: Dundee
country: United Kingdom
facility: Ninewells Hospital
city: Glasgow
country: United Kingdom
facility: Beatson Oncology Centre
city: Leicester
country: United Kingdom
facility: Leicester Royal Infirmary
city: London
country: United Kingdom
facility: Royal Marsden Hospital
city: London
country: United Kingdom
facility: Hammersmith Hospital
city: Plymouth
country: United Kingdom
facility: Derriford Hospital
city: Poole
country: United Kingdom
facility: Poole Hospital NHS Trust
city: Sheffield
country: United Kingdom
facility: Weston Park Hospital
city: Wirral
country: United Kingdom
facility: Clatterbridge Centre For Oncology
city: Wolverhampton
country: United Kingdom
facility: New Cross Hospital
Study officials:
References: