Clinical trial NCT00093626: Sorafenib in Treating Patients With Persistent or Recurrent Ovarian Epithelial or Peritoneal Cancer
Official title: A Phase II Evaluation of BAY 43-9006 (Sorafenib, Nexavar®, NCI-Supplied Agent, NSC #724772) in the Treatment of Persistent or Recurrent Epithelial Ovarian or Primary Peritoneal Carcinoma
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Primary Peritoneal Carcinoma
Recurrent Ovarian Carcinoma
Lead sponsor: National Cancer Institute (NCI)
Sponsor class: NIH
Collaborators: name: Gynecologic Oncology Group
First posted: 2004-10-08
Enrollment: 73
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Sorafenib may stop the growth of tumor cells by stopping blood flow to the tumor and by blocking the enzymes necessary for their growth. This phase II trial is studying how well sorafenib works in treating patients with persistent or recurrent ovarian epithelial or peritoneal cancer.

Detailed description: PRIMARY OBJECTIVES:

I. Determine the efficacy of sorafenib in patients with persistent or recurrent ovarian epithelial or primary peritoneal carcinoma.

II. Determine 6-month progression-free survival of patients treated with this drug.

III. Determine the toxicity of this drug, in terms of frequency and severity of adverse events encountered, in these patients.

SECONDARY OBJECTIVES:

I. Determine the clinical response rate (partial and complete response) in patients treated with this drug.

II. Determine the duration of progression-free and overall survival of patients treated with this drug.

III. Correlate prognostic variables (platinum sensitivity, performance status, and histology \[clear cell and mucinous type\]) with response in patients treated with this drug.

OUTLINE: This is a multicenter study.

Patients receive oral sorafenib twice daily on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Patients are followed every 3 months for 2 years and then every 6 months for 3 years.

PROJECTED ACCRUAL: Approximately 22-60 patients will be accrued for this study within 6-13 months.

Eligibility criteria: Inclusion Criteria:

* Histologically confirmed ovarian epithelial or primary peritoneal carcinoma

  * Persistent or recurrent disease
* Measurable or evaluable disease

  * Measurable disease is defined as at least 1 unidimensionally measurable lesion ≥ 20 mm by conventional techniques (including palpation, plain x-ray, CT scan, or MRI) OR ≥ 10 mm by spiral CT scan
  * Evaluable disease is defined as at least 1 of the following:

    * CA 125 ≥ 2 times upper limit of normal (ULN)
    * Ascites and/or pleural effusion attributed to tumor
    * Solid and/or cystic abnormalities on radiographic imaging that do not meet RECIST definition for target lesions
* Must have received 1 prior platinum-based chemotherapeutic regimen for primary disease, including carboplatin, cisplatin, or another organoplatinum compound

  * Initial treatment may have included high-dose therapy, consolidation, or extended therapy administered after surgical or non-surgical assessment
  * Platinum-resistant according to 1 of the following criteria:

    * Treatment-free interval of \< 12 months after platinum therapy
    * Disease progression during platinum-based therapy
    * Persistent disease after a platinum-based regimen
* Ineligible for higher priority GOG protocol (e.g., any active phase III GOG protocol for the same patient population)
* No brain metastases
* Performance status - GOG 0-2 (for patients who received 1 prior treatment regimen)
* Performance status - GOG 0-1 (for patients who received 2 prior treatment regimens)
* Absolute neutrophil count ≥ 1,500/mm\^3
* Platelet count ≥ 100,000/mm\^3
* No known bleeding diathesis
* Bilirubin ≤ 1.5 times ULN
* SGOT ≤ 2.5 times ULN
* Alkaline phosphatase ≤ 2.5 times ULN
* Creatinine ≤ 1.5 times ULN
* No symptomatic congestive heart failure
* No unstable angina pectoris
* No cardiac arrhythmia
* No uncontrolled hypertension
* Able to take oral medication
* No bowel obstruction or persistent vomiting
* No requirement for parenteral feedings
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective barrier contraception during and for 3 months after study participation
* No sensory or motor neuropathy \> grade 1
* No active or ongoing infection requiring antibiotics
* No history of allergic reaction attributed to compounds of similar chemical or biological composition to sorafenib
* No serious chronic skin conditions (i.e., psoriasis or dermatitis) that would preclude study participation
* No psychiatric illness or social situation that would preclude study compliance
* No other uncontrolled illness
* No other invasive malignancy within the past 5 years except nonmelanoma skin cancer
* At least 3 weeks since prior immunologic agents for the malignancy
* More than 4 weeks since prior mouse antibodies (for patients with evaluable disease only)
* No concurrent prophylactic growth factors (e.g., filgrastim \[G-CSF\])
* No concurrent prophylactic thrombopoietic agents except in the case of recurrent grade 4 thrombocytopenia
* No other concurrent biological agents for the primary tumor
* See Disease Characteristics
* More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) and recovered
* No prior non-cytotoxic chemotherapy for persistent or recurrent disease
* No concurrent chemotherapy for the primary tumor
* At least 1 week since prior hormonal therapy for the malignancy
* No concurrent hormonal therapy for the primary tumor

  * Concurrent hormone replacement therapy allowed
* More than 4 weeks since prior radiotherapy and recovered
* No prior radiotherapy to \> 25% of marrow-bearing areas
* No concurrent radiotherapy
* More than 4 weeks since prior surgery involving the peritoneum or pleura (for patients with evaluable disease only)
* Recovered from prior surgery
* At least 3 weeks since other prior therapy for the malignancy
* No more than 1 additional prior cytotoxic regimen for persistent or recurrent disease
* No prior sorafenib
* No prior anticancer treatment that would preclude study participation
* No concurrent therapeutic oral anticoagulation therapy (i.e., warfarin)

  * Concurrent prophylactic anticoagulation (i.e., low-dose warfarin) for central venous access devices allowed provided INR is \< 1.5
* No concurrent combination antiretroviral therapy for HIV-positive patients
* No other concurrent investigational or commercial agents or therapies for the malignancy

Primary outcomes:
measure: Frequency and severity of adverse events as assessed by CTCAE v3.0
timeFrame: Up to 5 years
measure: Progression-free survival
timeFrame: 6 months
Secondary outcomes:
measure: Duration of overall survival
timeFrame: Up to 5 years
measure: Duration of progression-free survival
timeFrame: Up to 5 years
measure: Frequency of clinical response (complete and partial response) defined by RECIST criteria
timeFrame: Up to 5 years
measure: Prognostic variables (platinum sensitivity, performance status, and cellular histology [clear cell or mucinous type])
timeFrame: Up to 5 years
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Gynecologic Oncology Group
state: Pennsylvania
Study officials:
affiliation: Gynecologic Oncology Group
name: Daniela Matei
role: PRINCIPAL_INVESTIGATOR
References: