Clinical trial NCT05469191: Eight-week Effect of the Sit-to-stand Test on Muscle Architecture.
Official title: Effect of the Sit to Stand Test on Muscle Architecture After Eight Weeks.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Quality of Life
Quality Muscle
Arquitecture Muscle
Lead sponsor: Universidad de Granada
Sponsor class: OTHER
First posted: 2022-07-21
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: A group that will perform the 5 STS will be compared with a group that will perform the 10 STS for 8 weeks, and there will also be a control group.
Primary purpose: BASIC_SCIENCE

Brief summary: An 8-week intervention of the sit-to-stand test (STS) of 5 and 10 repetitions will be performed to two randomly selected groups to compare its effect on the muscle architecture of the vastus lateralis muscle.

H1: 10 STS significantly modifies vastus lateralis muscle architecture in adults compared to 5STS and the control group.

Detailed description: Participants will be required to attend the laboratory for a first familiarization visit, where descriptive, biometric, and medical variables will also be evaluated. In addition, during this first familiarization session, it will be previously determined if the participants present any exclusion criteria and their muscle architecture will also be evaluated. After the familiarization session and the participants have signed the informed consent form, they will be randomly assigned to a 5 STS, 10 STS, or control group. Each group (exception of the control group) will be asked to perform three times a week one of the STS modalities assigned to them for 8 weeks, to ensure that the test is completed correctly and also to maintain the planning, the evaluator will be connected virtually with the participants, where rest times will be controlled and a fatigue perception scale will be performed at the end of each session, which will allow controlling the process each session. Subsequently, participants will be asked to attend the laboratory to re-evaluate their architectural parameters ( pennation angle, fascicle length, and muscle thickness) of the quadriceps muscle, one week after performing the intervention.

Eligibility criteria: Inclusion Criteria:

* Adults, over 18 years of age.
* They must have signed the informed consent form.
* Who can perform the STS.
* In case of suffering from a chronic non-communicable disease, that it is under control.

Exclusion Criteria:

* Inability to perform the STS.
* Hypertension (\>200/110 mmHg).
* Acute neuromuscular or joint injury.
* Who have suffered a stroke in the last 6 months.
* Who have suffered a myocardial infarction or fracture in the last 6 months.
* Terminally ill.
* People who practice a sport professionally.

Primary outcomes:
measure: Change in the pennation angle of the vastus lateralis muscle.
timeFrame: Before, 1 week completion of the intervention.
measure: Change in the length of the fascicle of the vastus lateralis muscle
timeFrame: Before, 1 week after completion of the intervention.
measure: Change in vastus lateralis muscle thickness
timeFrame: Before, 1 week after completion of the intervention.
measure: Change in muscle quality index (MQI)
timeFrame: Before, 1 week after completion of the intervention.
Secondary outcomes:
measure: Change in STS mean velocity (m· s-1), STS mean force (N), STS mean power (W), and STS relative power (W·Kg-1)
timeFrame: Before, 1 week after completion of the intervention.
Other outcomes:
Locations:
city: Valdivia
country: Chile
facility: Universidad San Sebastián, sede Valdivia.
Study officials:
affiliation: Universidad de Granada
name: Rodrigo Lizama Pérez, M.Sc
role: PRINCIPAL_INVESTIGATOR
References: