Clinical trial NCT03491020: Emission Patterns of Respiratory Pathogens
Official title: Emission Patterns of Respiratory Pathogens
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Pathogen Transmission
Keywords: Emission Patterns
Respiratory
Aerosolization
Airborne
Lead sponsor: Wake Forest University Health Sciences
Sponsor class: OTHER
First posted: 2018-04-06
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients \>18 years of age admitted to the ED or an inpatient care unit of Wake Forest Baptist Medical Center (WFBMC) will be screened for respiratory pathogens (performed as part of standard clinical care). Participants with positive respiratory pathogen tests will be consecutively enrolled.

Brief summary: Airborne transmission represents one of the most rapidly spreading and dangerous dissemination mechanisms for pathogens. Public health strategies to prevent and control the often explosive outbreaks associated with such pathogens are: 1) vaccination and treatment, if available, 2) isolation and barrier precautions such as face masks, and 3) decontamination of the exposed areas and surfaces. A lack of understanding how these pathogens are transmitted hampers the ability to develop effective prevention measures. This study will be used to collect preliminary data of the emission patterns of respiratory pathogens.

Detailed description: Airborne transmission represents one of the most rapidly spreading and dangerous dissemination mechanisms for pathogens. The study team have been investigating bacterial and viral transmission routes and barrier precautions. In a recent clinical study, it was observed that Measles virus RNA was detected from a patient for at least up to 10 feet. In addition, the group has been studying barrier precautions (facemasks) for their ability to prevent the spread of aerosolized viruses. Finally, in a controlled lab setting the investigators have assessed the impact of environmental conditions (temperature, humidity) on pathogen transmission and the effect of UV-C light to prevent the spread of influenza. The purpose of this observational study is to describe the human aerosolization patterns of respiratory pathogens. The study team hypothesizes that the emission patterns of specific airborne pathogens varies between individual patients.

Eligibility criteria: Inclusion Criteria:

* patients \>18 years of age admitted to the ED or an inpatient care unit of Wake Forest Baptist Medical Center (WFBMC)
* Positive

Exclusion Criteria:

* positive respiratory pathogen tests

Primary outcomes:
measure: particle size distribution patterns: ICU
timeFrame: throughout study completion, up to 7 days
measure: particle size distribution patterns: non-ICU setting
timeFrame: throughout study completion, up to 7 days
measure: quantities of the pathogen: ICU
timeFrame: throughout study completion, up to 7 days
measure: quantities of the pathogen: non-ICU setting
timeFrame: throughout study completion, up to 7 days
measure: spatial model: ICU
timeFrame: throughout study completion, up to 7 days
measure: spatial model: non-ICU setting
timeFrame: throughout study completion, up to 7 days
measure: correlation between the human aerosolization patterns and the severity of illness
timeFrame: throughout study completion, up to 7 days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Wake Forest University Health Sciences
name: Werner Bischoff, MD
role: PRINCIPAL_INVESTIGATOR
References: