Clinical trial NCT05930262: Acupuncture Therapy Combined With Breathing Training for Patients With Stroke Complicated
Official title: Acupuncture Therapy Combined With Breathing Training for Patients With Stroke Complicated With Pulmonary Infection: A Clinical Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke
Lung Diseases
Keywords: Acupuncture therapy
Respiratory training
Seroinflammatory factors
Lung function
Lead sponsor: The Second Hospital of Hebei Medical University
Sponsor class: OTHER
First posted: 2023-07-05
Enrollment: 72
Sex: ALL
Minimum age (years): 28
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The goal of this prospective randomized controlled study is to explore the clinical efficacy of acupuncture therapy combined with breathing training in patients with stroke complicated with pulmonary infection. The intervention group and control group were treated with conventional drug therapy, rehabilitation therapy and breathing training for 2 consecutive weeks. On this basis, the intervention group additionally received acupuncture therapy. To evaluate the clinical efficacy of both groups.

Detailed description: To explore the clinical efficacy of acupuncture therapy combined with breathing training in patients with stroke complicated with pulmonary infection. Using a prospective randomized controlled study, 72 patients with pulmonary infection after stroke admitted to our hospital from May 2020 to May 2021 were randomly divided into the intervention group and control group, with 36 patients in each group. Both groups were treated with conventional drug therapy, rehabilitation therapy and breathing training for 2 consecutive weeks. On this basis, the intervention group additionally received acupuncture therapy. The traditional Chinese medicine (TCM) syndrome score and clinical pulmonary infection score (CPIS) before and after treatment, time of fever relieving, time for the disappearance of cough, expectoration and moist rales in the lung, white blood cell count (WBC), serum C-reactive protein (CRP) level, calcitonin (PCT) level and pulmonary indexes were compared between the 2 groups, respectively, to evaluate clinical efficacy.

Eligibility criteria: Inclusion Criteria:

* Meeting the diagnostic criteria of Western medicine for stroke complicated with pneumonia
* conforming to the TCM syndrome of vital qi deficiency and phlegm-heat obstructing the lung
* confirmed as the initial onset of stroke through CT or magnetic resonance imaging (MRI)
* clear consciousness, no cognitive impairment, and ability to cooperate with pulmonary function assessment and rehabilitation training
* willingness to participate in this study and sign the informed consent

Exclusion Criteria:

* Patients with systemic multi-organ failure such as the heart, brain, kidney, etc
* patients with a coronary metal stent or pacemaker implantation
* patients with malignant tumors
* patients with severe cognitive impairment, depression or mental disorders
* patients with pulmonary infections before stroke or caused by other causes
* patients in the acute phase of infection

Primary outcomes:
measure: Serum inflammatory factors：C-reactive protein (CRP) level
timeFrame: 2 Weeks
measure: Serum inflammatory factors：Calcitonin (PCT) level
timeFrame: 2 Weeks
measure: Serum inflammatory factors：WBC
timeFrame: 2 Weeks
measure: Improvement time for symptoms and signs of pulmonary infection：Time of fever relieving
timeFrame: 2 Weeks
measure: Improvement time for symptoms and signs of pulmonary infection：Time for the disappearance of cough
timeFrame: 2 Weeks
measure: Improvement time for symptoms and signs of pulmonary infection：Time for the disappearance of expectoration
timeFrame: 2 Weeks
measure: Improvement time for symptoms and signs of pulmonary infection：Time for the disappearance of moist rales
timeFrame: 2 Weeks
measure: TCM syndrome score
timeFrame: 2 Weeks
measure: Clinical pulmonary infection score (CPIS)
timeFrame: 2 Weeks
measure: Pulmonary indexes:forced vital capacity (FVC)
timeFrame: 2 Weeks
measure: Pulmonary indexes:forced expiratory volume in the first second (FEV1)
timeFrame: 2 Weeks
measure: Pulmonary indexes: peak expiratory flow (PEF)
timeFrame: 2 Weeks
measure: Efficacy evaluation:Number of patients with clinical efficacy（Cured，Effective，Remarkably effective，Invalid）
timeFrame: 2 Weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Shijiazhuang
country: China
facility: Acupuncture Therapy Combined with Breathing Training for Patients with Stroke Complicated with Pulmonary Infection: A Clinical Study
state: Hebei
Study officials:
References: