Clinical trial NCT06089226: Parameters Related to Physical Activity Level in SCI
Official title: The Relationship Between Physical Activity Level and Cardiovascular Fitness and Respiratory Parameters in Individuals With Spinal Cord Injury
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Spinal Cord Injuries
Respiratory Complication
Cardiovascular Complication
Lead sponsor: Istinye University
Sponsor class: OTHER
First posted: 2023-10-18
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Participants diagnosed with spinal cord injury classified as group A, B, C or D according to the American Spinal Injury Association (ASIA)

Brief summary: Spinal cord injury (SCI) is a devastating health condition associated with permanent disability and reduced life expectancy. It is stated that its annual incidence worldwide varies between 12.1 and 57.8 per million, and its prevalence varies between 236 and 1009 per million.

SCI negatively affects the physical, psychological, and social well-being of individuals by causing sensory, motor, and autonomic dysfunction. The level of disability associated with SCI is different for each injury and varies depending on the level and type of injury. However, physical activity (PA), cardiovascular fitness, and respiratory system are commonly observed to be affected in most individuals with SCI.

Due to inadequate control of somatic and autonomic systems, a decrease in the cardiovascular response to PA and exercise occurs. A decrease in PA level and systemic disorders after injury promote sedentary behavior and negatively affect cardiovascular fitness in individuals with SCI. Cervical and thoracic spinal cord injuries compromise the function of the respiratory muscles and significantly impair both inspiratory and expiratory function. It also interrupts the sympathetic innervation of the lungs and creates restrictive changes in the physiological and mechanical properties of the lungs. The broad effects of SCI on lung capacity may have implications for cardiovascular fitness. Adequate ventilation is critical to provide adequate oxygen to working muscles during prolonged physical activities. During moderate and high-intensity physical activities, ventilation increases in proportion to oxygen consumption to maintain arterial oxygen concentration and allow continuous PA.

Knowing the relationship between PA, cardiovascular fitness, and respiratory parameters after SCI is essential in guiding the course of rehabilitation after SCI. Battikha et al. They reported that respiratory capacity plays an important role in limiting exercise capacity in individuals with SCI. However, the relationship between PA and cardiovascular fitness and respiratory parameters has not been fully examined in individuals with SCI.

In this study, the investigators hypothesize the relationship between PA, cardiovascular fitness and respiratory parameters. Accordingly, this study aims to determine the relationship between PA, cardiovascular fitness and respiratory parameters in individuals with SCI.


Eligibility criteria: Inclusion Criteria:

* Classified as group A, B, C or D (diagnosed with spinal cord injury) according to the American Spinal Injury Association (ASIA),
* Fully or partially wheelchair dependent
* Having the upper extremity muscle strength required to use a wheelchair
* Those who are over 18 years old
* Patients without cognitive impairment

Exclusion Criteria:

* Those with any progressive disease
* Bedridden,
* Patients with severe cognitive impairment

Primary outcomes:
measure: Physical Activity Scale for Individuals with Physical Disabilities
timeFrame: 1 week
measure: The Wheelchair Propulsion Test
timeFrame: 1 week
measure: Forced vital capacity
timeFrame: 1 week
measure: Forced expiratory volume in the first second
timeFrame: 1 week
measure: Forced vital capacity/Forced expiratory volume Ratio
timeFrame: 1 week
measure: Peak expiratory flow rat
timeFrame: 1 week
measure: Respiratory muscle strength
timeFrame: 1 week
Secondary outcomes:
measure: Sociodemographic Information and Health Status Information
timeFrame: 4 weeks
measure: Body Weight Measurement
timeFrame: 1 week
measure: Height Measurement
timeFrame: 1 week
measure: Body mass index
timeFrame: 1 week
measure: Waist Circumference Measurement
timeFrame: 1 week
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istinye University
Study officials:
References: