Clinical trial NCT06147557: Effect of Passive Heat Therapy on Metabolism
Official title: Effect of Repeated Brief Passive Heat Therapy on Metabolism in Healthy Young Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Lead sponsor: Lithuanian Sports University
Sponsor class: OTHER
First posted: 2023-11-27
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The goal of this prospective interventional study is to examine if repeated brief hot stimuli affects glucose metabolism and substrate oxidation in young non-obese adults. Young adult participants were asked to participate in fourteen 5-min procedures involving whole body passive heating at 45°C water.

The main question it aims to answer is: "Does repeated brief noxious heat stimuli is sufficient to improve glucose tolerance, insulin sensitivity, and fat oxidation in young non-obese adults?"

Detailed description: No studies yet addressed whether brief heat stimuli could be viable time-efficient alternative approach in order to improve glucose metabolism and fat oxidation. Consequently, we aimed to examine the ability of brief noxious heat stimuli to improve glucose tolerance, insulin sensitivity, and fat oxidation in young adults. Non-obese males and females completed fourteen 5-min sessions involving whole body passive heating at 45°C water. Changes in catecholamines, cytokines, substrate oxidation, resting energy expenditure, glucose tolerance and insulin response were assessed.

Eligibility criteria: Inclusion Criteria:

* healthy non-obese (BMI between 18.5 and 29.9 kg/m2) males and females;
* no diseases, or conditions that could be worsened by exposure to acute hot water and affect experimental variables;
* no participation in any excessive formal physical exercise or sports program, temperature manipulation program or exposure to extreme temperatures.

Exclusion Criteria:

* smokers;
* obesity (BMI greater than 30 kg/m2);
* needle phobia;
* taking medication and/or dietary supplements that may affect experimental variables.

Primary outcomes:
measure: Changes in catecholamines concentration (ng/mL)
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
measure: Changes in cytokines concentration (pg/mL)
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
measure: Change in glucose concentration (mmol/L)
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
measure: Change in insulin concentration (μIU/mL)
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
measure: Change in insulin sensitivity
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
measure: Change in substrate oxidation
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
measure: Change in fat oxidation (g/min
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
measure: Change in fat oxidation (g/min)
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
measure: Change in resting energy expenditure (kcal/day)
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
Secondary outcomes:
measure: Change in body mass (kg)
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
measure: Change in fat mass (kg)
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
measure: Change in fat mass (%)
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
measure: Change in fat free mass (kg)
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
measure: Change in fat free mass (%)
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
measure: Change in body mass index (kg/m2)
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
measure: Change in oxygen consumption and carbon dioxide output (mL/min)
timeFrame: Pre-condition, post-condition (after 14 days), and after 1 month recovery
Other outcomes:
Locations:
city: Kaunas
country: Lithuania
facility: Institute of Sport Science and Innovations
Study officials:
affiliation: Lithuanian Sports University
name: Marius Brazaitis, PhD
role: PRINCIPAL_INVESTIGATOR
References: