Clinical trial NCT01888991: Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men
Official title: Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Food Intake Regulation
Substrate Oxidation
Keywords: Glucose
Exercise
Metabolic flexibility
Substrate Oxidation
Food intake
Lead sponsor: University of Toronto
Sponsor class: OTHER
Collaborators: name: Canadian Institutes of Health Research (CIHR)
First posted: 2013-06-28
Enrollment: 30
Sex: MALE
Minimum age (years): 9
Maximum age (years): 29
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.

Detailed description: The relationship between substrate oxidation as measured by respiratory exchange ratio (RER) and food intake is undefined. This study is examining the effects of three modulators of substrate oxidation (RER), a glucose preload, exercise and age food intake regulation and net energy balance in normal-weight boys (9-12 y) and men (20-30 y).

Subjects (15 boys, 15 men) were measured in random order with treatments of beverages of either water or glucose followed by either moderate exercise or rest for 40 min. Measures included RER via indirect calorimetry, energy expenditure, subjective appetite, food intake measured at an ad libitum pizza meal and net energy balance as the sum of the calories of the glucose preload + calories from the pizza lunch minus energy expended at exercise or rest.

Eligibility criteria: Inclusion Criteria:

* Born at full term
* Men Age:20-29 years/BMI: 20-25
* Boys Age 9-11/BMI percentile: 15th to 85th:

Exclusion Criteria:

* Smokers
* Dieters
* Individuals with lactose intolerance, allergies to milk and dairy products
* Individuals with gastrointestinal problems
* Individuals with diabetes or other metabolic diseases
* Individuals scoring ≥ 11 on an Eating Habit Questionnaire

Primary outcomes:
measure: Food Intake
timeFrame: 60 - 90 min in the study
Secondary outcomes:
measure: Net Energy Balance
timeFrame: 0-90 min in the study
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Department of Nutritional Sciences, University of Toronto
state: Ontario
Study officials:
affiliation: University of Toronto
name: Harvey Anderson, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Tamam S, Bellissimo N, Patel BP, Thomas SG, Anderson GH. Overweight and obese boys reduce food intake in response to a glucose drink but fail to increase intake in response to exercise of short duration. Appl Physiol Nutr Metab. 2012 Jun;37(3):520-9. doi: 10.1139/h2012-038. Epub 2012 Apr 25.
citation: Bellissimo N, Thomas SG, Goode RC, Anderson GH. Effect of short-duration physical activity and ventilation threshold on subjective appetite and short-term energy intake in boys. Appetite. 2007 Nov;49(3):644-51. doi: 10.1016/j.appet.2007.04.004. Epub 2007 Apr 22.
citation: Bozinovski NC, Bellissimo N, Thomas SG, Pencharz PB, Goode RC, Anderson GH. The effect of duration of exercise at the ventilation threshold on subjective appetite and short-term food intake in 9 to 14 year old boys and girls. Int J Behav Nutr Phys Act. 2009 Oct 9;6:66. doi: 10.1186/1479-5868-6-66.
citation: Hunschede S, El Khoury D, Antoine-Jonville S, Smith C, Thomas S, Anderson GH. Acute changes in substrate oxidation do not affect short-term food intake in healthy boys and men. Appl Physiol Nutr Metab. 2015 Feb;40(2):168-77. doi: 10.1139/apnm-2014-0188. Epub 2014 Oct 22.