louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05912725: Conventional Impressions Versus Digital Impression Techniques for Implant Supported Screw Retained Prosthesis
Official title: Evaluation of the Accuracy of Conventional and Digital Implant Impression Techniques in Bilateral Distal Extension Cases
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Partial Edentulism Class 1
Keywords: Digital impression
implant impression
impression accuracy
Digital work flow
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2023-06-22
Enrollment: 8
Sex: ALL
Minimum age (years): 30
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose was to evaluate the accuracy of traditional and digital implant level impression procedures by using three-dimensional superimposition analysis , and evaluate the passive fit of screw- retained implant supported restorations fabricated using conventional and digital impression techniques in bilateral distal extension cases (class I kennedy classification)

Detailed description: Eight patients who had missing all mandibular posterior teeth except first premolars were included in this study. In each patient, 4 implants were placed, 2 in each side to support 3 units screw retained zirconia restorations. Three months after implant placement, each patient underwent two implant level impression techniques (n=8) for each technique: Conventional implant impressions CII (pick-up, splinted transfers), and digital implant impressions DII were captured with TRIOS 3 Shape intraoral optical scanner. In this study, digital impression was considered as a reference data.

Eligibility criteria: Inclusion Criteria:

* All participants have sufficient bone length and width for implant insertion.
* General health of the patients was evaluated by taking a full medical history to ensure that these patients were free from any systemic conditions that would have impaired implant osseointegration
* Good oral hygiene
* Sufficient inter-arch spaces
* The opposing arch was almost dentulous, and any missing teeth were restored using a fixed partial denture.

Exclusion Criteria:

* parafunctional habits
* Heavy smoking
* Those patients with systemic diseases that may influence soft or hard tissue healing.
* Patients with a history of radiation therapy in the head and neck region.
* Patients with a history of radiation therapy in the head and neck region.

Primary outcomes:
measure: Accuracy of digital and conventional implant impression techniques in partially edentulous patient
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Wafaa youssif El ashry
Study officials:
affiliation: Tanta university ,Faculty of Dentistry, Prosthodontics department
name: Wafaa Y El ashry, MSc
role: PRINCIPAL_INVESTIGATOR
affiliation: Tanta university, Faculty of Dentistry, Prosthodontics department
name: Wafaa Y El ashry
role: PRINCIPAL_INVESTIGATOR
affiliation: Tanta University
name: Wafaa Y El ashry, MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04663425: Outcome of Bariatric Surgery in Patients With BMI Greater Than 60 .
Official title: Is Bariatric Surgery Effective in Super-super Morbid Obese Patients?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bariatric Surgery Candidate
Lead sponsor: Assuta Medical Center
Sponsor class: OTHER
First posted: 2020-12-11
Enrollment: 59
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients accepted to underwent bariatric surgery with BMI equal or above 60

Brief summary: Patients that underwent any type of bariatric surgery with BMI more than 60 will recruited for follow up that includes: actual weight, other surgeries and conversions, co-morbidities status, medications and satisfaction.

Detailed description: Patients that underwent bariatric surgery for BMI =60 or greater were considered for the study. The type of surgery were be analyze related to weight loss. Complication and operation difficulty will be assessed.

Co morbidities and treatment results post surgery will be considered as also, need for revisional surgery/

Eligibility criteria: Inclusion Criteria:

BMI above 60 Any bariatric surgery performed including revision

Exclusion Crite ria: Tourist patients Patients under 18 years old

-

Primary outcomes:
measure: Weight loss after bariatric surgery
timeFrame: from 1 to 12 years
measure: co-morbidities rate following surgery
timeFrame: from 1 to 12 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06476925: Role of Left Stellate Ganglion Block in Offering Myocardial Protection in On-pump Mitral Valve Replacement? A Histopathological and Clinical Assessment
Official title: Role of Left Stellate Ganglion Block in Offering Myocardial Protection in On-pump Mitral Valve Replacement? A Histopathological and Clinical Assessment
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Open Mitral Cardiac Surgery
Lead sponsor: Minia University
Sponsor class: OTHER
First posted: 2024-06-27
Enrollment: 100
Sex: ALL
Minimum age (years): 25
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Can pre-operative left stellate ganglion block offer myocardial protection in on-pump mitral valve replacement? A histopathological and clinical assessment.


Eligibility criteria: Inclusion Criteria:

* Adult population of both sex, between 25-50 years, will undergo elective on pump mitral valve replacement

Exclusion Criteria:

* -Combined valve replacement ( mitral and aortic or mitral and tricuspid valves replacement).
* Emergency valve replacement ( stuck valve, infective endocarditis).
* Pre-operative cardiomyopathy (Ejection fraction less than 45%).
* Recent myocardial infarction ( within 6 months)
* Redo mitral valve replacement.
* Pre-operative pacing, or cardioverter, any form arrhythmia ( tachy or brady).
* Previous history of carotid endarterectomy or presence of carotid stent.
* On thrombolytic therapy.
* Severe chronic obstructive airway disease,
* Patient refusal

Primary outcomes:
measure: Number of patients with microscopic myocardial injury
timeFrame: intra-operative
Secondary outcomes:
measure: Intra-operative arrhythmia
timeFrame: intraoperatively
measure: postoperative arrhythmia
timeFrame: first, second and third day after bypass
measure: Troponin I
timeFrame: before operation, immediately after ICU admission and 3 days post-operative
measure: Myocardial function
timeFrame: pre-operative, one week
measure: weaning from mechanical ventilation
timeFrame: 24 hours post-operative
measure: Time of cardiopulmonary bypass
timeFrame: Intraoperative
measure: Length of ICU stay
timeFrame: one week
measure: Need for pacing
timeFrame: intraoperative and one week after
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01559025: Evaluation of Vildagliptin (Galvus®) as add-on to Insulin in New-onset Type 1 Diabetes Mellitus
Official title: Evaluation of Vildagliptin (Galvus®) as add-on to Insulin in Residual β-cell Function and Inflammatory Markers in New-onset Type 1 Diabetes Mellitus.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Type 1 Diabetes
Insulin Dependent Diabetes
Juvenile Onset Diabetes Mellitus
Autoimmune Diabetes
Keywords: Type 1 diabetes
Vildagliptin
Galvus
Lead sponsor: Federal University of São Paulo
Sponsor class: OTHER
Collaborators: name: Novartis
First posted: 2012-03-20
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary objective of this study is to evaluate the action of DPP-IV inhibitors in the prevention of progressive beta cell dysfunction in patients with type 1 diabetes mellitus newly diagnosis ( less than 6 months).

The secondary objectives are:

1. To define the immune and inflammatory profile
2. To define the secretion of glucagon and GLP-1
3. To assess the glycemic variability

Detailed description: Clinical and autopsy studies show that up to 30% of patients with type 1 diabetes mellitus show a detectable β-cell function at clinical diabetes. The preservation of this endogenous insulin production, even if it is small, can have a great impact on the evolution of long-term disease through improving glycemic control, reducing chronic diabetes complications and hypoglycemia. Strategies for preventing the loss of beta cell are based on stopping the autoimmune process and also in the preservation and regeneration of beta cells. Currently have been questioned the potential use of GLP-1 for new-onset type 1 diabetes. The justification for this issue is based on the fact that this class of drugs, besides acting on insulin secretion and glucose regulation, may be effective to preserve and expand beta cell mass, which has been shown in animals. Ideal candidates for this treatment are newly diagnosed patients who still have significant viable beta cell mass.

Eligibility criteria: Inclusion Criteria:

* Aged 18 to 35 years
* Up to 6 months of clinical diagnosis
* Fasting C-peptide ≥ 0.25 ng / ml
* HbA1C \<9.0%
* Positive autoantibodies (anti-GAD, Anti-Insulin and Anti-IA2)
* Without chronic complications

Exclusion Criteria:

* Hepatic, cardiac, pulmonary and hematologic disease

Primary outcomes:
measure: Beta cell function
timeFrame: C peptide will be measured by the area under the curve of stimulated C peptide within the first 2 hours every 3 months up to one year
Secondary outcomes:
measure: Immune and inflammatory profile
timeFrame: 0,3,6,9,12th months
measure: Secretion of Glucagon and GLP-1
timeFrame: 0,3,6, 9 and 12months
measure: Glycemic variability
timeFrame: 0, 6 and 12months
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Federal University of São Paulo
Study officials:
affiliation: FUSãoPaulo
name: Sérgio Dib
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03394625: Evaluate Marginal B. Loss in Immediate Implant Placement in Maxillary Esthetic Zone Using Socket Shield Versus Xenograft
Official title: Evaluation of Marginal Bone Loss in Immediate Implant Placement in Maxillary Esthetic Zone Using Socket Shield Technique Versus Xenogenous Bone Substitute Material
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Marginal Bone Loss in Socket Shield Technique
Keywords: Socket Shield
immediate implant
ridge preservation
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2018-01-09
Enrollment: 18
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Anterior maxilla (Esthetic zone) is very challenging area because of thin buccal plate of bone. After tooth extraction physiological process occur causing alteration of bone and soft tissue so, delayed placement of implant lead to loss of bone height and width. Immediate placement of implant is become essential to preserve the bone and soft tissue from loss.

Socket shield technique is a recent technique which is by sectioning the root and extraction of palatal part and leaving buccal part of the root with its attachment of periodontal ligament and vascularization still intact then placing implant in palatal socket. This technique allow preservation of buccal plate of bone and soft tissue with minimum loss allowing better result in esthetic zone.


Eligibility criteria: Inclusion Criteria:

* Patients with badly broken teeth in upper esthetic zone with intact periodontal condition indicated for extraction, presence of at least 4 mm of bone beyond the root apex to guarantee implant primary stability, implant placement within the alveoli confines.
* Both sexes.
* No intraoral soft and hard tissue pathology.
* Physically able to tolerate conventional surgical and restorative procedures.
* Signing of an informed consent form.

Exclusion Criteria:

* Presence of fenestrations or dehiscence of the residual bony walls after extraction.
* Heavy smokers more than 20 cigarettes per day .(24)
* Patients with systemic disease that may affect normal healing e.g. uncontrolled diabetes.
* Psychiatric problems e.g. severe bruxism.
* Disorders to implant are related to history of radiation therapy to the head and neck neoplasia, or bone augmentation to implant site.
* Active infection in the teeth to be treated
* Vertical root fractures with displacement in the teeth of the surgical area

Primary outcomes:
measure: marginal bone loss
timeFrame: 4 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo University
Study officials:
References:
Clinical trial NCT04270825: Group Treatment for Hoarding Disorder
Official title: Group Treatment for Hoarding Disorder
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hoarding Disorder
Lead sponsor: Florida State University
Sponsor class: OTHER
First posted: 2020-02-17
Enrollment: 8
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Participants will receive a novel treatment for hoarding disorder.
Primary purpose: TREATMENT

Brief summary: This study assesses the effectiveness of a novel group treatment for hoarding disorder.

Detailed description: The primary aim of this study is to investigate the effectiveness of a novel group treatment for hoarding disorder. Participants will be randomized to receive either treatment as usual (cognitive behavioral therapy: CBT) or treatment as usual augmented by interpersonal psychotherapy (IPT). It is hypothesized that group CBT with IPT will result in greater decreases in hoarding symptoms, as compared to standard group CBT. It is further hypothesized that CBT with IPT will result in greater reductions in object attachment and maladaptive beliefs about relationships with others, as well as greater increases in interpersonal attachment.

Eligibility criteria: Inclusion Criteria:

-Clinical diagnosis of HD

Exclusion Criteria:

* Evidence of a severe mental illness or substance use disorder that would impede the completion of the treatment
* Current receipt of CBT for HD
* Initiation of new psychotropic medications for symptoms of HD

Primary outcomes:
measure: Changes in Hoarding Rating Scale (HRS)
timeFrame: Baseline, 10 weeks, 20 weeks, 24 weeks
measure: Changes in Reciprocal Attachment Questionnaire Adapted (RAQ-A)
timeFrame: Baseline, 10 weeks, 20 weeks, 24 weeks
measure: Changes in Adult Attachment Scale (AAS)
timeFrame: Baseline, 10 weeks, 20 weeks, 24 weeks
measure: Changes in Interpersonal Needs Questionnaire (INQ)
timeFrame: Baseline, 10 weeks, 20 weeks, 24 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Tallahassee
country: United States
facility: Florida State University
state: Florida
Study officials:
References:
Clinical trial NCT06726525: Hydroxypropyl-methylcellulose and GlicoPro® Eyedrops in the Treatment of Dry Eye Disease: Clinical Study
Official title: Hydroxypropyl-methylcellulose and GlicoPro® Eyedrops in the Treatment of Dry Eye Disease: Clinical Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Dry Eye
Keywords: dry eye disease
GlicoPro®
Hydroxypropyl-methylcellulose
Lead sponsor: University of Milan
Sponsor class: OTHER
Collaborators: name: FB VISION, Ascoli Piceno, Italy
name: University of Messina
First posted: 2024-12-10
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to learn if Hydroxypropyl-methylcellulose and GlicoPro® eyedrops work to treat mild-to-moderate dry eye disease in adult patients. The main questions it aims to answer are:

Do Hydroxypropyl-methylcellulose and GlicoPro® eyedrops reduce patients' symptoms? Do Hydroxypropyl-methylcellulose and GlicoPro® eyedrops increase patients' tear film stability? Researchers will compare Hydroxypropyl-methylcellulose and GlicoPro® eyedrops to Hydroxypropyl-methylcellulose without GlicoPro® eyedrops to see if Hydroxypropyl-methylcellulose and GlicoPro® formulation works better to treat dry eye..

Participants will

* Take Hydroxypropyl-methylcellulose and GlicoPro® eyedrops or Hydroxypropyl-methylcellulose eyedrops every day for 3 months
* Visit the clinic 3 times in 3 months for checkups and tests


Eligibility criteria: Inclusion Criteria:

* Age \>18 years
* Ocular Surface Disease Index (OSDI) \>12 AND \<65
* Fluorescein breakup time (FBUT) \<10 seconds OR (Oxford staining Score \>1 AND \<4).

Exclusion Criteria:

* Systemic or ocular diseases with known effect on tear film and ocular surface
* Systemic or ocular medications with known effect on tear film and ocular surface
* Contact lens wearing,
* Ocular surgery in the 12 months before enrollment
* Known allergy or poor tolerance to any ingredient of the study products
* Presumed poor compliance to study procedures.

Primary outcomes:
measure: Ocular Surface Disease Index (OSDI) overall treatment effect
timeFrame: From enrollment to the end of treatment at 3 months
measure: Symptom Assessment iN Dry Eye (SANDE) overall treatment effect
timeFrame: From enrollment to the end of treatment at 3 months
measure: Fluorescein Break-up time (FBUT) overall treatment effect
timeFrame: From enrollment to the end of treatment at 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Mesina
country: Italy
facility: Ophthalmology Clinic, Dept. of Biomedical Sciences, University of Messina, Messina, Italy
Study officials:
affiliation: University of Milan
name: Edoardo Villani, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT03901625: Halitosis During Active Orthodontic Treatment
Official title: The Efficacy of Different Methods of Teeth Cleaning on the Levels of Volatile Sulfur Compounds in Patients With Orthodontic Fixed Appliances
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Halitosis
Lead sponsor: Riyadh Colleges of Dentistry and Pharmacy
Sponsor class: OTHER
First posted: 2019-04-03
Enrollment: 60
Sex: ALL
Minimum age (years): 14
Maximum age (years): 50
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: To determine the effect of different cleaning methods and devices in reducing halitosis during active orthodontic treatment.

Detailed description: . Observer - blind clinical trial, randomly divided into four groups, A, B, C and D. each group will undergo clinical evaluation and oral malodor assessment and they will be assigned electric or manual toothbrushes with super floss or water floss respectively.clinical evaluation will include plaque index (PI), gingival bleeding index (GBI), bracket index.and halitosis will be measured by halimeter .

Measurements and time frame: Initial measurements (T0), after two weeks (T1), and after four weeks (T2) ( according to previous studies that uses the same period of time for measurements),17, 18 plaque index (PI), gingival bleeding index (GBI), bracket index and halimeter reading .

During the first week after the start of the study (T0)

Eligibility criteria: Inclusion Criteria:

1. participants with fixed orthodontic appliance.
2. participants age 14 years and above and didn't have mental of physical disabilities.
3. participants willing to comply with given oral hygiene instructions.

Exclusion Criteria:

1. patients with mental retardation.
2. patients with systematic diseases.

Primary outcomes:
measure: Change in volatile sulphur compounds causing halitosis at four weeks.
timeFrame: At baseline then and after four weeks then
measure: Change in volatile sulphur compounds causing halitosis at eight weeks.
timeFrame: At four weeks from baseline and after eight weeks then
Secondary outcomes:
Other outcomes:
Locations:
city: Riyadh
country: Saudi Arabia
facility: Riyadh Elm University
state: Ar Riyad
Study officials:
References:
Clinical trial NCT05737225: Regional Anesthesia for Percutaneous Transluminal Angioplasty
Official title: The Effect of Regional Anesthesia Method on Tissue Oxygenation in Patients Who Will Undergo Percutaneous Transluminal Angioplasty
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Peripheral Artery Occlusive Disease
Percutaneous Transluminal Angioplasty
Keywords: percutaneous transluminal angioplasty
tissue oxygenation
Lead sponsor: Gazi University
Sponsor class: OTHER
First posted: 2023-02-21
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: ASA I-III patients over the age of 18 who have been decided to perform elective PTA as a treatment method for peripheral arterial disease will be included in the study.

Brief summary: In this study, the effects of regional anesthesia method applied in patients who will undergo percutaneous transluminal angioplasty for lower extremity revascularization will be investigated comparatively.


Eligibility criteria: Inclusion Criteria:

* Age: \> 18 years
* Peripheral artery occlusive disease
* Eligibility for PTA

Exclusion Criteria:

* Patients' refusal
* Under the age of 18
* Language problems (not knowing turkish)
* Psychological or mental disorders.
* Disturbance of Conscious level.
* Uncooperative patients
* Those who are allergic to anesthetic drugs to be used
* Those with contraindications for the application of peripheral nerve block (coagulopathy, skin infection at the block site)
* need for endotracheal intubation or general anesthesia

Primary outcomes:
measure: Tissue Oxygenation
timeFrame: During procedure
Secondary outcomes:
measure: Body Temperature of Lower Extremities
timeFrame: During procedure
measure: Patient Satisfaction Score
timeFrame: 15 minutes after procedure
measure: Surgeon Satisfaction Score
timeFrame: 15 minutes after procedure
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gazi University
Study officials:
References: