Clinical trial NCT03482726: Cadence Modulation to Improve Well-Being, Kinematics and Aerobic Performance in Cyclists
Official title: Cadence Modulation to Improve Well-Being, Kinematics and Aerobic Performance in Cyclists
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: bicycle
cadence
cyclist
modulation
Lead sponsor: University of Wisconsin, Madison
Sponsor class: OTHER
First posted: 2018-03-29
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 89
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: This study will utilize a combination of cardiovascular analysis, 3D motion capture, and a software package, Metrifit, to monitor measures of well-being to comprehensively evaluate both the musculoskeletal and physiological responses following a HIIT training intervention at EOC as a means of improving performance and potentially reducing injury risk factors. This holistic approach of physiological and biomechanical factors is unprecedented. This is the first interventional study to determine the effect of high intensity training at EOC on cardiovascular performance, kinematics and well-being which may minimize risk of injury factors.

Detailed description: In the first session, each individual will be asked to fill out a questionnaire to regarding cycling experience, prior bike fits (with data sheets when available), and injury history. Maximal aerobic capacity (VO2max) will be determined. During the test, subjects will be asked rate exertion. Before testing, the system will be calibrated with known oxygen and carbon dioxide concentrations. During the test, subjects will be asked to breathe normally through a low dead space bidirectional turbine. Inspired and expired gases will be analyzed for concentrations of O2 and CO2, to determine alveolar gas exchange. Total ventilation (VE), respiratory rate, oxygen consumption (VO2), carbon dioxide (VCO2) will be measured, and respiratory exchange ratio (RER; VCO2/VO2) will be calculated continuously during the test and expressed as a 30-second rolling average.

Participants will return 48 hours later, at which time EOC will be determined after a moderate intensity prolonged cycling exercise (PCE) at seven different cadences. Cadences from 50rpm to 110rpm will be randomly generated and introduced every 3 minutes, followed by a 3 minute cool down at FCC at 40% PP (Figure Subjects will then be pair matched by gender and randomized into control (FCC) or EOC modulation groups.

48 hours following EOC testing, subject will return for a second progressive maximal cycling test performed at FCC or EOC based on group assignment.

Subjects will then participate in a 6 week high intensity training (HIIT) indoor cycling program at their prescribed cadence (FCC or EOC), using cadence meters. Training will consist of three non-consecutive days each week for 60 min, and alternate between two HIIT workouts. Resistance will be increased to meet the HIIT requirement, while cadence will remain at FCC or EOC. Subjects will be asked to warm-up at a light (3/10) workload for 10 minutes, followed by HIIT consisting of 4 minutes at an intensity of 8/10 on the modified Borg, and 90 seconds recovery (2/10). This will be repeated 8 times, followed by 10 minutes of cool down. The alternating HIIT workout will include a 10 minute warm up, followed by 12 intervals lasting 2 minutes at an RPE of 9/10 and 3 minutes of recovery. The session will conclude with a 10 minute cool down.

Within one week of completing their training program, subjects will return for their fourth and final study visit, at which time a VO2max test and kinematic data collection will be repeated at FCC or EOC.

Eligibility criteria: Inclusion Criteria:

1. An experienced cyclist will be defined as one with at least 5 years of cycling experience and 5000 miles of training on a road bike with a clipless pedal system.
2. Able to tolerate strenuous, maximal exercise and comply with a 6 week training protocol
3. Have access to an indoor trainer or spin bike with a cadence sensor in order to train 3 times per week for 60 minutes

Exclusion Criteria:

1. Taking medication which could impact cardiovascular function or performance (stimulants, beta-blockers, e.g.)
2. Significant cardiac or pulmonary disease (congenital cardiac disease, uncontrolled hypertension, uncontrolled asthma, e.g.)
3. Musculoskeletal injuries that preclude a maximal cycling effort and participation in training program

Primary outcomes:
measure: Time to exhaustion T(max)
timeFrame: Baseline
measure: Ventilatory threshold (VT)
timeFrame: Baseline
measure: Maximal cardiac output
timeFrame: Baseline
measure: Maximal stroke volume
timeFrame: Baseline
measure: decreased trunk lean
timeFrame: Baseline
measure: decreased ankle dorsiflexion
timeFrame: Baseline
measure: decreased knee splay
timeFrame: Baseline
Secondary outcomes:
measure: Improved VO2 max
timeFrame: 6 weeks
measure: Increased O2 consumption at VT
timeFrame: 6 weeks
measure: Time to VT
timeFrame: 6 weeks
measure: Time to T(max)
timeFrame: 6 weeks
measure: decreased trunk lean
timeFrame: 6 weeks
measure: decreased ankle dorsiflexion
timeFrame: 6 weeks
measure: decreased knee splay
timeFrame: 6 weeks
measure: change in overall soreness and fatigue
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Madison
country: United States
facility: University of Wisconsin
state: Wisconsin
Study officials:
affiliation: University of Wisconsin, Madison
name: Andrew M Watson, MD
role: PRINCIPAL_INVESTIGATOR
References: