Clinical trial NCT05402462: Esophageal Motility Disorders in Patients With Non-cardiac Chest Pain at Assiut University Hospital
Official title: Esophageal Motility Disorders in Patients With Non-cardiac Chest Pain at Assiut University Hospital
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Esophageal Motility Disorders
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2022-06-02
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: to determine the prevalence and distribution of esophageal motility disorders in NCCP patients who presented after a negative cardiac evaluation and underwent esophageal manometry, esophageal pH monitoring

Brief summary: to determine the prevalence and distribution of esophageal motility disorders in NCCP patients who presented after a negative cardiac evaluation and underwent esophageal manometry, esophageal pH monitoring

Detailed description: Non-cardiac chest pain (NCCP) is defined as recurrent anginalike pain without evidence of cardiac disease \[1\]. NCCP is a common disorder and accounts for 14-33% of patient visits to gastroenterologists \[2\]. These patients frequently undergo testing for reflux and esophageal motility as gastroesophageal reflux disease (GERD) is seen in 50-60% and esophageal motility disorders in 15-18% of the patients \[3,4\]. Nutcracker esophagus was thought to be the classic manometric finding in NCCP \[5\] but other studies have reported ineffective esophageal motility (IEM) as the most common motility disorder in NCCP \[6,7\]. Furthermore, up to one-third of patients do not have any GERD or motility disorders and are labeled as functional chest pain \[8\]. Suggested causes in these patients include esophageal hypersensitivity \[9\], abnormal cerebral pain processing and psychological comorbidity \[10\]. The clinical predictors of abnormal esophageal function tests in NCCP have not been identified. Identifying these factors would lead to limited use of testing in those with risk factors and faster institution of pain modulator therapy in patients who are most likely to have functional chest pain.

Eligibility criteria: Inclusion Criteria:

1. Age above 18 years
2. Patients presented with non-cardiac chest pain

Exclusion Criteria:

* 1- age below 18. 2- cardiac chest pain patients

Primary outcomes:
measure: Esophageal motility disorders in patients with non-cardiac chest pain at Assiut University hospital
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
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citation: Fass R, Dickman R. Non-cardiac chest pain: an update. Neurogastroenterol Motil. 2006 Jun;18(6):408-17. doi: 10.1111/j.1365-2982.2006.00787.x.
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citation: Ribolsi M, Balestrieri P, Biasutto D, Emerenziani S, Cicala M. Role of Mixed Reflux and Hypomotility with Delayed Reflux Clearance in Patients with Non-cardiac Chest Pain. J Neurogastroenterol Motil. 2016 Oct 30;22(4):606-612. doi: 10.5056/jnm15182.
citation: Barret M, Herregods TV, Oors JM, Smout AJ, Bredenoord AJ. Diagnostic yield of 24-hour esophageal manometry in non-cardiac chest pain. Neurogastroenterol Motil. 2016 Aug;28(8):1186-93. doi: 10.1111/nmo.12818. Epub 2016 Mar 27.
citation: Remes-Troche JM. How to Diagnose and Treat Functional Chest Pain. Curr Treat Options Gastroenterol. 2016 Dec;14(4):429-443. doi: 10.1007/s11938-016-0106-y.
citation: Farmer AD, Ruffle JK, Aziz Q. The Role of Esophageal Hypersensitivity in Functional Esophageal Disorders. J Clin Gastroenterol. 2017 Feb;51(2):91-99. doi: 10.1097/MCG.0000000000000757.
citation: Zhang L, Tu L, Chen J, Song J, Bai T, Xiang XL, Wang RY, Hou XH. Health-related quality of life in gastroesophageal reflux patients with noncardiac chest pain: Emphasis on the role of psychological distress. World J Gastroenterol. 2017 Jan 7;23(1):127-134. doi: 10.3748/wjg.v23.i1.127.