Clinical trial NCT02677467: Correlation Between Epistaxis and Cardiovascular Disease
Official title: Epistaxis Correlate With Cardiovascular Disease?
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cardiovascular Disease
Epistaxis
Lead sponsor: Hanyang University
Sponsor class: OTHER
First posted: 2016-02-09
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Group A : A participant enroll if their age is over 18 with spontaneous epistaxis and their cause of visiting ER is spontaneous epistaxis. Exclusion criteria is that they needs immediately treatment for hypertensive urgency. And, they don't want to participate in this investigation.

Group B : A participant enroll if their age is over 18 with bleeding of wound and their cause of visiting ER is to bleed on wound. Exclusion criteria is that their wounds' condition is serious or their pain is much severe. And, they don't want to participate in this investigation.

Brief summary: Investigators examine blood-pressure variance, several cardiovascular risk factors of patient with epistaxis. As a result of collected data, investigators look into correlation between epistaxis and hypertensive cardiovascular disorder.

Detailed description: This study is prospective observational single blinded study.

A participant is visit in the ER who patient with epistaxis.

Investigators will enroll 50 patients with epistaxis. Exclusion criteria is that patient needs immediately treatment for hypertensive urgency or patient with nasal trauma.

Investigators examine blood-pressure (BP) at five times in Emergency Department (ED) and out-patient department (opd) of Otorhinolaryngology (OL) . Investigators explain this study and ask to write consent for participant. After proper management of epistaxis, investigators get blood sampling of the participant and, the participant has a reservation to "opd of cardiovascular division of Internal Medicine" (CV opd) in the hospital.

When the participant visit CV opd, the participant undergo 24-hours-BP-monitoring and Pulse wave velocity (PWV).

After that, the participant will be follow-up for 3 months.

Investigators collect 50 data from 50 participants as a registry and analyze the data.

Eligibility criteria: Group A

Inclusion Criteria:

* age is over 18 with spontaneous epistaxis

Exclusion Criteria:

* they needs immediately treatment for hypertensive urgency.
* they don't want to participate in this investigation.

Group B

Inclusion Criteria:

* age is over 18 with bleeding of wound

Exclusion Criteria:

* their wounds' condition is serious or their pain is much severe.
* they don't want to participate in this investigation.

Primary outcomes:
measure: Cholesterol level in each group
timeFrame: 1 day
measure: BP variability level in each group
timeFrame: 1 day
measure: Pulse wave velocity in each group
timeFrame: 1 day
Secondary outcomes:
measure: Smoking History in each group
timeFrame: 1 day
measure: Body Mass Index in each group
timeFrame: 1 day
Other outcomes:
Locations:
city: Guri-si
country: Korea, Republic of
facility: Hanyang University Guri Hospital
state: Gyeonggi-do
Study officials:
affiliation: Hanyang University
name: JUNGHOON SHIN, M.D., Ph.D.
role: STUDY_CHAIR
References: