Clinical trial NCT06736067: Effects of a Single-bout of Moderate-intensity Aerobic Exercise on Mood and Mental Health Biomarkers in Adults with Depressive And/or Anxiety Symptoms
Official title: Effects of a Single-bout of Moderate-intensity Aerobic Exercise on Mood and Mental Health Biomarkers in Adults with Depressive And/or Anxiety Symptoms
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Depression Symptoms
Anxiety Symptoms
Lead sponsor: The Hong Kong Polytechnic University
Sponsor class: OTHER
First posted: 2024-12-16
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: This study investigates whether a single session of aerobic exercise (like running) can improve the participants' mood and whether such benefits can be explained by changes in the blood factors (like hormones) and brain activity.

The main questions this study aims to answer are:

* Can a single session of aerobic exercise improve mood?
* Which changes in the blood and brain could explain the effects of exercise on mood?

Researchers will compare the participants' mood states before and after exercise to see whether exercise can improve mood.

The participants will:

* Answer questionnaires, collect blood, and undergo magnetic resonance imaging (MRI) before exercise.
* Perform 30 minutes of running on a treadmill.
* Answer the same questionnaires, collect blood, and undergo magnetic resonance imaging (MRI) after exercise.

The entire assessment will last for about 2h45min and will be performed on a single day.


Eligibility criteria: Inclusion Criteria:

* Healthy subjects within the stipulated age range

Exclusion Criteria:

* Acute injury or illness that impairs the ability to safely exercise and/or inability to exercise with a moderate intensity;
* Metabolic and/or neurologic disorders;
* Iron implants;
* People who cannot stay still, are intolerant of noise or fearful of enclosed spaces (due to the small space inside the scanner).

Primary outcomes:
measure: Profile of Mood States (POMS)
timeFrame: From before to immediately after a single session of exercise
Secondary outcomes:
measure: Subjective Exercise Experience Scale (SEES)
timeFrame: From before to immediately after a single session of exercise
measure: Subject Happiness Scale (SHS)
timeFrame: From before to immediately after a single session of exercise
measure: Blood biomarkers
timeFrame: From before to immediately after a single session of exercise
measure: Cardiovascular parameters
timeFrame: Before, during, and immediately after a single session of exercise
measure: BOLD-weighted fMRI images
timeFrame: From before to immediately after a single session of exercise
measure: Diffusion-weighted image (DWI)
timeFrame: From before to immediately after a single session of exercise
measure: Magnetic resonance spectroscopy (MRS)
timeFrame: From before to immediately after a single session of exercise
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: The Hong Kong Polytechnic University
Study officials:
References: