louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04268043: Comparation of Proseal Laryngeal Mask Airway With Flexible Laryngeal Airway Mask
Official title: Comparation of Efficacy and Safety of Proseal Laryngeal Mask Airway With Flexible Laryngeal Airway Mask in Otitis Media Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Anesthesia Intubation Complication
Lead sponsor: Eye & ENT Hospital of Fudan University
Sponsor class: OTHER
First posted: 2020-02-13
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Objective To investigate the comparative effect of proseal laryngeal mask airway and flexible laryngeal airway mask during otitis media surgery. Methods 200 patients of ASA I or II classification, 18-65 years old, BMI\<30 kg/m2 undergoing otitis media surgery are randomly divided into two groups (Group P with proseal laryngeal mask airway and Group F with flexible laryngeal airway mask, respectively). After induction, selecting a appropriate size of LMA to patient,s weight, using the standard index finger-guided technique inserting the LMA, and then the patients were ventilated mechanically. The success rate of inserting laryngeal mask, the intubation time, surgery time and wake time were also recorded. Tidal volume and leakage pressure in patients with supine and lateral positioning were assessed respectively. The scale of fiberoptic bronchoscopy was also recorded to show airway exposure. Related complications such as sore throat, hoarseness, cough, laryngospasm, bloating, nausea and vomiting, soft tissue injury, blood residue after pulling out the LMA were analyzed.Postoperative voice and laryngopharyngeal symptom are also recorded.


Eligibility criteria: Inclusion Criteria:

Clinical diagnosis of otitis media.

Exclusion Criteria:

Problems with the upper airway. Gastric carcinoma. Reflux esophagitis.

Primary outcomes:
measure: successful insert rate
timeFrame: 0 minute after insertion
measure: tidal volume
timeFrame: 5 minute afer successful insertion
measure: leakage pressure
timeFrame: 5 minute afer successful insertion
measure: The scale of fiberoptic bronchoscopy
timeFrame: 0 minute afer successful insertion
measure: Number of Participants with cranial nerve injury
timeFrame: 1hours after the surgery
Secondary outcomes:
measure: Number of Participants with sore throat
timeFrame: 1hours after the surgery
measure: Number of Participants with hoarseness
timeFrame: 1hours after the surgery
measure: Number of Participants with cough
timeFrame: 1hours after the surgery
measure: Number of Participants with laryngospasm
timeFrame: 1hours after the surgery
measure: Number of Participants with soft tissue injury
timeFrame: 1hours after the surgery
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04372043: Evaluation of the Sleep Hygiene in the Lebanese Population During the COVID-19 Confinement Period.
Official title: Evaluation of the Sleep Hygiene in the Lebanese Population During the COVID-19 Confinement Period.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Sleep Hygiene
Lead sponsor: Saint-Joseph University
Sponsor class: OTHER
First posted: 2020-05-01
Enrollment: 1200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The Lebanese population living in Lebanon during the confinement period of the COVID-19 pandemic.

Brief summary: The term "sleep hygiene" refers to a series of healthy sleep habits that can improve the ability to fall asleep. These habits are the most effective long-term treatment for people with chronic insomnia. The "Sleep Hygiene Index" is a 13-item questionnaire that evaluates these habits. We are in the process of validation of this questionnaire in the arabic language.

We will evaluate these habits in the Lebanese population during the COVID-19 confinement period.

Detailed description: The sleep hygiene will be evaluated during the COVID-19 confinement period. The "Sleep Hygiene Index" with other questions will be applied to the Lebanese population in english and arabic. It will be distributed by the means of WhatsApp and Facebook.

Eligibility criteria: Inclusion Criteria:

* Lebanese living in Lebanon, 18 YO and over, understanding written english or arabic.

Exclusion Criteria:

* Not having the inclusion criteria.

Primary outcomes:
measure: Sleep Hygiene
timeFrame: 30/04/2020 to 30/12/2020
Secondary outcomes:
Other outcomes:
Locations:
city: Beirut
country: Lebanon
facility: Saint Joseph University
Study officials:
affiliation: USJ
name: Jeanine El Helou, MD, MSc
role: STUDY_CHAIR
References:
Clinical trial NCT01387243: Survey on the Pharmacy Follow-up of Alli Purchasers
Official title: Survey on the Pharmacy Follow up of Alli Purchasers
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Overweight
Keywords: behavior modification
overweight
orlistat
Lead sponsor: GlaxoSmithKline
Sponsor class: INDUSTRY
First posted: 2011-07-04
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Consumers purchasing orlistat in a pharmacy setting

Brief summary: To assess the feasibility and acceptability of genuine pharmacy follow up of people wishing to lose weight.


Eligibility criteria: Inclusion Criteria:

* Individuals who have been recognized as being eligible for treatment, who have agreed to pharmacy follow up, and have given their informed consent to take part in the survey.

Primary outcomes:
measure: Change in Physical activity
timeFrame: baseline to 1 year
Secondary outcomes:
measure: Change in dietary behavior
timeFrame: baseline to 1 year
measure: Evaluation of care pathway (e.g., consultation with doctors, use of nutritional information)
timeFrame: baseline to 1 year
measure: Satisfaction with management (i.e., results on weight and treatment comfort)
timeFrame: baseline to 1 year
Other outcomes:
Locations:
Study officials:
affiliation: GlaxoSmithKline
name: GSK Clinical Trials
role: STUDY_DIRECTOR
References:
Clinical trial NCT04313543: Glycemic Index of Longan Syrup in Healthy Volunteers
Official title: Determination of Glycemic Index of Longan Syrup in Healthy Volunteers
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Healthy
Keywords: Longan
Glycemic
Glucose
Lead sponsor: Chulalongkorn University
Sponsor class: OTHER
First posted: 2020-03-18
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: Volunteers take 50 g of glucose in 250 ml of water in 5 minutes.Then, they are tested blood glucose levels (taken from the fingertips) at 15, 30 ,45, 60, 90, and 120 minutes. There is 3 days for wash out period. These tests will be repeated for 3 times for baseline glucose calculation. After that, volunteers take 50 g of longan syrup in 250 ml of water in 5 minutes.Then, they are tested blood glucose levels (taken from the fingertips) at 15, 30 ,45, 60, 90, and 120 minutes. Glycemic index of longan syrup is calculated from area under the curved of blood glucose after longan syrup taking divided to mean of area under the curved of blood glucose after glucose taking.


Eligibility criteria: Inclusion Criteria:

* Ages 18-60 years
* Never diagnosis as diabetes mellitus of thyroid dysfunction
* Fasting plasma glucose less than 100 mg/dl
* Body mass index 18.5-24.9 kg/m2
* Be willing to be subjects in this study

Exclusion Criteria:

* Know longan allergy or have history of adverse events from longan
* Take medicines, herbs, or food supplements including thiazide diuretics, beta-blockers ,and estrogen that have an effect on blood sugar level in 1 month before this study starting
* Severe comorbidity or uncontrolled diseases
* Pregnancy and lactation
* Participated in other studies

Primary outcomes:
measure: Blood glucose
timeFrame: Change from glucose baseline in 120 minutes
Secondary outcomes:
measure: Adverse events
timeFrame: 12 days
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06428643: A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities
Official title: A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities in Black Youth Living in the Deep South
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Chlamydia
Gonorrhea
Hiv
Syphilis
Keywords: Screening
Expedited Treatment
Lead sponsor: Tulane University
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
name: National Institute of Allergy and Infectious Diseases (NIAID)
First posted: 2024-05-24
Enrollment: 2322
Sex: ALL
Minimum age (years): 15
Maximum age (years): 26
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Community based screening of young men for chlamydia, gonorrhea, HIV, and syphilis. Expedited treatment for positive subjects and their sexual partners.
Primary purpose: SCREENING

Brief summary: This study includes testing for four STIs (chlamydia, gonorrhea, syphilis, and HIV) at no cost. If positive, individual subjects will also be counseled and offered options for treatment for themselves and their sex partners that may include no cost expedited treatment and the option to be rescreened 3 months after treatment.


Eligibility criteria: Inclusion Criteria:

* Identifies as African American or Black
* 15-26 years of age
* Lives or spends most of their time in Orleans Parish
* Had vaginal sex at least once

Exclusion Criteria:

* Unwilling or unable to provide informed consent
* Unable to speak or understand English
* Previously enrolled in the study
* Known to be pregnant
* Known HIV positive status

Primary outcomes:
measure: Rate of chlamydia in women
timeFrame: up to 60 months
Secondary outcomes:
measure: Rate of gonorrhea in women
timeFrame: up to 60 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04509843: Impact of Socioeconomic Status and Oral Hygiene Practice on Periodontal Health of Egyptian Adults
Official title: Impact of Socioeconomic Status and Oral Hygiene Practice on Periodontal Health of Egyptian Adults: A Hospital Based Cross-sectional Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Periodontal Health
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-08-12
Enrollment: 456
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: patients will be recruited in a consecutive manner from the outpatient Diagnostic center, Faculty of Dentistry, Cairo University.

Brief summary: evaluation the relationship between the socioeconomic status and periodontal health of Egyptian adults.

Detailed description: It is a cross-sectional study for evaluation and assessment of periodontal health, socioeconomic status and oral hygiene measurements among Egyptian adults recruiting from the outpatient clinic and the payed treatment clinics at faculty of Dentistry, Cairo University.

The faculty of Dentistry, Cairo University is an open public facility, a tertiary healthcare and a referral center.

Eligibility criteria: Inclusion Criteria:

* -Patients whose age is 18-70 years old recruiting from the outpatient clinic and the payed clinic
* Provide informed consent.

Exclusion Criteria:

* Patients having problem in opening their mouth or undergoing intermaxillary fixation where oral examination will not be possible.
* Patients diagnosed with psychiatric problems or intoxicated with alcohol or drugs.
* pregnant patients.
* patients undergoing orthodontic treatment.
* patients who had undergone periodontal treatment over the past six months.

Primary outcomes:
measure: Periodontal health
timeFrame: "through study completion, an average of 1 year"
measure: periodontal disease
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
measure: Impact of sociodemographic factors on periodontal health
timeFrame: through study completion, an average of 1 year
measure: impact of periodontal practice on periodontal health
timeFrame: through study completion, an average of 1 year
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Dentistry
Study officials:
References:
Clinical trial NCT00838643: Invasive Aspergillosis After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Official title: Incidence of Invasive Aspergillosis in Allogeneic Stem Cell Transplantation Patients: an Italian Prospective Multicentre Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hematological Diseases
Invasive Aspergillosis
Keywords: allogeneic transplantation
Invasive aspergillosis
Lead sponsor: Ospedale Santa Croce-Carle Cuneo
Sponsor class: OTHER
First posted: 2009-02-06
Enrollment: 220
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients given allogeneic HSCT in tertiary care centers or university hospitals in Piedmont

Brief summary: Evaluation of incidence of invasive aspergillosis in patients who have undergone an allogeneic stem cell transplantation, with particular regard to the role of galactomannan assay and of early TC scan in asymptomatic patients.


Eligibility criteria: Inclusion Criteria:

* Age \> 16 years
* Allogeneic HSCT for a haematological disease
* Written informed consent to the study

Exclusion Criteria:

* Pediatric patients

Primary outcomes:
measure: Incidence of invasive aspergillosis
timeFrame: 1 year
Secondary outcomes:
measure: Clinical applicability of the EORTC/MSG criteria in a prospective multicenter trial
timeFrame: 1 year
Other outcomes:
Locations:
city: Cuneo
country: Italy
facility: Azienda Sanitaria Ospedaliera santa Croce e Carle
Study officials:
References:
Clinical trial NCT02210143: An Explorative Study To Develop A Predictive Model Based On Avascular Exposed Root Surface Area For Root Coverage
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Gingival Recession
Lead sponsor: Cukurova University
Sponsor class: OTHER
First posted: 2014-08-06
Enrollment: 91
Sex: ALL
Minimum age (years): 21
Maximum age (years): 41
Standard ages: ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Ninety one patients, 41 females and 50 males, aged between 21-41 years, with 91 isolated single gingival recessions (32 Miller I, 29 Miller II, 30 Miller III defects) located at upper and lower incisors and canines.

Brief summary: The aim of this study was to evaluate the reliability of the avascular root surface area as a prognostic identification criterion for gingival recessions and to compare the predictive value of the Miller classification and avascular root surface area (AERSA) calculation on the final root coverage outcomes.


Eligibility criteria: Inclusion Criteria:

* Presence of isolated Miller I, II or III recession, (Miller 1985a)
* Presence of identifiable cementoenamel junction (CEJ); presence of a step ≤ 2mm at CEJ level and/or the presence of a root abrasion, but with an identifiable CEJ,
* Full-mouth plaque score and Full-mouth bleeding score of \< 15% (four sites/tooth),
* No occlusal interferences;
* Non-smokers

Exclusion Criteria:

* Tooth with a prosthetic restoration involving CEJ,
* Patients with a history of periodontitis or abscess formation,
* Presence of systemic disease or taking medications known to interfere with periodontal tissue health
* Pregnant or nursing patients

Primary outcomes:
measure: Complete root coverage
timeFrame: 6 months
Secondary outcomes:
measure: mean root coverage
timeFrame: 6 months
Other outcomes:
Locations:
city: Adana
country: Turkey
facility: Cukurova University Ethics Comitee
state: Balcali
Study officials:
References:
Clinical trial NCT01123343: Clinical Evaluation of TrueVision System: LRI and Capsulorhexis Templates
Official title: CLINICAL EVALUATION OF THE TRUEVISION 3D VISUALIZATION AND GUIDANCE SYSTEM FOR MICROSURGERY: LRI AND CAPSULORHEXIS TEMPLATES
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Subjects Undergoing Cataract Surgery and Insertion of IOL
Keywords: limbal relaxing incision
LRI
capsulorhexis
surgical guidance
3d visualization
Lead sponsor: TrueVision Systems, Inc
Sponsor class: INDUSTRY
First posted: 2010-05-14
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To evaluate the ability of the TRUEVISION 3D VISUALIZATION AND GUIDANCE SYSTEM FOR MICROSURGERY to provide the ophthalmic surgeon appropriate alignment, orientation and sizing information during cataract or refractive lens exchange surgery. Device images, safety results and surgeon questionnaire will demonstrate that the TrueVision system provides clear images to assist surgeons during LRI or capsulorhexis procedures.


Eligibility criteria: Inclusion Criteria:

* Healthy eye with no previous ocular surgery
* Natural lens for which phacoemulsification extraction and posterior IOL implantation is planned
* Clear intraocular media other than cataract
* Potential visual acuity 20/30 or better
* Able to comply with preop and postop examination procedures
* Signed and dated informed consent

Exclusion Criteria:

* Keratometric astigmatism \> 2.5 diopters
* Corneal pathology potentially affecting topography including corneal degeneration
* Irregular astigmatism
* Macular degeneration or any other macular disease which reduces potential acuity
* Previous corneal surgery (including LASIK, radial keratotomy, penetrating keratoplasty, etc)
* Use of systemic or ocular medications that affects vision
* Acute or chronic systemic or ocular disease or illness that would increase risk or confound study results
* Use of Flomax or any other medication which negatively impacts surgical outcomes
* History of ocular trauma or ocular surgery

Primary outcomes:
measure: Demonstrate that the TrueVision system provides clear images to assist during LRI or capsulorhexis procedures
timeFrame: one month
Secondary outcomes:
Other outcomes:
Locations:
city: Eugene
country: United States
facility: Drs. Fine, Hoffman and Packer
state: Oregon
Study officials:
affiliation: Oregon Eye Associates
name: Mark Packer, MD
role: STUDY_DIRECTOR
affiliation: Eye Institute of West Florida
name: Robert Weinstock, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Durrie Vision
name: Jason Stahl, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Sansum Clinic
name: Douglas Katsev, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05850143: EFFECTIVENESS OF SINGLE DOSE ORAL DEXAMETHASONE VERSUS MULTIDOSE PREDNISOLONE FOR TREATMENT OF ACUTE EXACERBATIONS OF ASTHMA AMONG CHILDREN ATTENDING THE EMERGENCY DEPARTMENT OF CHILDREN HOSPITAL, ISLAMABAD
Official title: EFFECTIVENESS OF SINGLE DOSE ORAL DEXAMETHASONE VERSUS MULTIDOSE PREDNISOLONE FOR TREATMENT OF ACUTE EXACERBATIONS OF ASTHMA AMONG CHILDREN ATTENDING THE EMERGENCY DEPARTMENT OF CHILDREN HOSPITAL, ISLAMABAD
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Asthma in Children
Lead sponsor: Shaheed Zulfiqar Ali Bhutto Medical University
Sponsor class: OTHER
First posted: 2023-05-09
Enrollment: 192
Sex: ALL
Minimum age (years): 2
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: OTHER

Brief summary: In this Study i'll compare the effectiveness of two drugs used in acute exacerbation of asthma by their sideffects, complaince and improvement in the PRAM score. The better one would be adapted in our clinical practice.


Eligibility criteria: Inclusion Criteria:

* i.Ages 2 to 12years ii. Previous history of asthma as diagnosed by a physician. iii. Presentation with acute exacerbation of asthma with symptoms of cough, wheeze, dyspnoea and oxygen saturation of less than 95% and with PRAM score of more than or equal to 6

Exclusion Criteria:

* i.Critical or life-threatening asthma i.e. patient with silent chest, cyanosis, drowsy, unable to verbalize, marked tachycardia and respiratory distress. ii.Known TB exposure iii.Fever more than 39. 5°C iv.Use of corticosteroids in previous 4 weeks v.Significant co-morbid disease: lung, cardiac, immune, liver, endocrine, neurological or psychiatric

Primary outcomes:
measure: Improvement in PRAM score
timeFrame: 4 days
Secondary outcomes:
Other outcomes:
Locations:
city: Islamabad
country: Pakistan
facility: Asim Nawaz Niazi
Study officials:
References:
Clinical trial NCT03894943: Quantitative Sensory Testing and PET/CT Scanning in Assessment of Surgical Outcome for Lumbar Disc Herniation
Official title: Quantitative Sensory Testing and PET/CT Scanning in Assessment of Surgical Outcome for Lumbar Disc Herniation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lumbar Disc Herniation
Radiculopathy Lumbar
Keywords: PET/CT
Lead sponsor: Spine Centre of Southern Denmark
Sponsor class: OTHER
Collaborators: name: Odense University Hospital
First posted: 2019-03-29
Enrollment: 61
Sex: ALL
Minimum age (years): 40
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Patients with lumbar disc herniation suffer from pain and morbidity. Surgical intervention can be a quick and effective relief, however some individuals experience less favorable outcome.

This study tries to investigate and test the differences in pain perception and pain modulation between individuals. Using PET/CT scans the investigators try to visualize pain perception and -modulation in the CNS. This is subsequently correlated with a battery of pain tests and the surgical outcome of disc herniation surgery.


Eligibility criteria: Inclusion Criteria:

* Informed consent
* Clinical and radiological indication for LDH surgery, assessed by an experienced spinal surgeon
* Age 40-65 years
* Able to comply with regulations regarding medicine consumption (stated below)

Exclusion Criteria:

* History of previous spine surgery
* General contra-indication for spine surgery
* Greatly reduced kidney function
* Diagnosis of psychiatric disorder
* Current malignant disease
* History of radiation therapy
* Current chemotherapy
* History of spinal fracture
* Hematologic disease
* Current pregnancy or breast-feeding
* Chronic, generalized connective tissue disorders or chronic, non-specific pain disorders (fibromyalgia, whiplash (WAD I-V), etc.)

Primary outcomes:
measure: EuroQol-5D 3L
timeFrame: 1 year
measure: Oswestry Disability Index
timeFrame: 1 year
measure: Visual Analogue Scale
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Sygehus Lillebælt
name: Christian Støttrup, MD
role: PRINCIPAL_INVESTIGATOR
References: