Clinical trial NCT03567226: Leveraging WeChat Social-Media and Messaging Platform to Increase Physical Activity in Chinese Glaucoma Patients
Official title: Leveraging WeChat Social-Media and Messaging Platform to Increase Physical Activity in Chinese Glaucoma Patients: A Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Glaucoma
Lead sponsor: Johns Hopkins University
Sponsor class: OTHER
Collaborators: name: Wenzhou Medical University
First posted: 2018-06-25
Enrollment: 102
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The positive effects of exercise on ocular health are known, but modern lifestyles have made it difficult to incorporate physical activity into the daily lives of the Chinese population. Recent studies suggest that exercise plays an important role in lowering intraocular pressure (IOP) by protecting retinal ganglion cells (RGCs) in glaucoma patients as well as other potential neuroprotective benefits. Increasing the amount of physical activity within the Chinese glaucoma population may have marked effects on health outcomes and coincides with the Chinese government's efforts to make exercise an urgent public health priority. There is a need for innovative, cost-effective, and proven interventions to promote exercise behavior change and social media platforms may be able to fill this niche. WeChat is China's largest and most frequently used social media and messaging application with an estimated 570 million users. The platform has been found to be a useful tool in healthcare settings to promote weight-loss, health literacy, and patient adherence in Chinese populations. This study is a 5-weeks randomized control trial with three total study visits. 80 patients from an academic glaucoma clinic in Wenzhou Medical College will be randomized into two groups. The intervention group will be enrolled into an Official WeChat Group and receive periodic reminders to exercise, health education materials, and motivational incentives. The control group will receive weekly reminders and leaflets at the first clinic visit. Patients' daily step data will be monitored using an Accelerometer WGT3X-BT. The intervention duration will include an initial clinic visit, a one-week follow-up after wearing the accelerometer, and then a subsequent one-month follow-up visit after wearing the accelerometer. At the one-week visit the patient will be randomized and at the subsequent one-month visit there will be a close-out discussion about the study. In addition to collecting step data at clinic visits, investigators will also measure patients' visual field tests, optical coherence tomography angiography (angio-OCT), and intraocular pressure (IOP) using Goldmann Tonometry. The investigators' hypothesis is that using an Official WeChat Patient Group will be a robust and effective stimulus to increase physical exercise.


Eligibility criteria: Inclusion Criteria:

* Glaucoma diagnosis
* Age 40 years and above
* Ability to sign informed consent
* Ability to use WeChat

Exclusion Criteria:

* Patients with severe heart, lung, or kidney disease which may prevent them from exercising
* Patients who self-report walking 12,000 steps or more per day

Primary outcomes:
measure: Efficacy of using WeChat as an intervention to increase physical activity in Chinese glaucoma patients
timeFrame: 5 weeks
Secondary outcomes:
measure: Time spent in moderate to vigorous physical activity
timeFrame: 5 weeks
Other outcomes:
Locations:
city: Wenzhou
country: China
facility: The affiliated eye hospital of Wenzhou Medical University
state: Zhejiang
Study officials:
affiliation: Johns Hopkins University
name: David Friedman, MD, MPH, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Clinical & Epidemiological Eye Research Centre, The affiliated eye hospital of Wenzhou Medical University
name: Yuanbo Liang, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: