louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05313126: Immuno-epidemiological and Socio-behavioral Evaluation of Release of Sterile Male Aedes Albopictus Mosquitoes on Human-vector Contacts
Official title: Immuno-epidemiological and Socio-behavioral Evaluation of Release of Sterile Male Aedes Albopictus Mosquitoes on Human-vector Contacts
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Mosquito Bite
Lead sponsor: Institut de Recherche pour le Developpement
Sponsor class: OTHER_GOV
First posted: 2022-04-06
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: A Cluster-Non Randomized Controlled Trial
Primary purpose: PREVENTION

Brief summary: This trial is based on 2 complementary components, named ExpAlbo Biomarker and CAPAlbo Questionnaire

1. ExpAlbo Biomarker (Exposure to the Aedes albopictus mosquito): This component concerns the epidemiological evaluation of the effectiveness of the release of sterile male mosquitoes on the level of exposure of individuals to the bites of the tiger mosquito through the use of a new immunological biomarker of the human-vector contact, developed over the past 20 years by the IRD-MIVEGEC team. Indeed, when a person is bitten by a mosquito, he or she develops a defence reaction, called an immune reaction, against the mosquito's saliva. The main objective of this study is to measure this immune response, and more specifically the antibody response specifically directed against compounds (peptide = small fragment of a protein) in mosquito saliva, and to determine whether this anti-saliva antibody response, and therefore exposure to mosquito bites, decreases when the mosquito control strategy is applied.
2. CAPAlbo Questionnaire: This component is concerned with assessing the impact of sterile male mosquito releases on perceptions and practices related to exposure to Aedes albopictus based on population-based questionnaire surveys. The main objective of these surveys is to determine whether changes in objective exposure to Aedes albopictus mosquitoes are associated with changes in the perception of the nuisance and in the lifestyle habits of respondents, particularly those related to the prevention of mosquito bites (such as the use of repellents or mosquito nets).


Eligibility criteria: Inclusion Criteria:

* To inhabit on a regular basis in the intervention/control area
* To speak French

Primary outcomes:
measure: Immunological indicators
timeFrame: 6 months
measure: Immunological indicators
timeFrame: 12 months
measure: Exposure to Aedes mosquito
timeFrame: 6 months
measure: Exposure to Aedes mosquito
timeFrame: 12 months
Secondary outcomes:
measure: Protective behavior
timeFrame: 6 months
measure: Protective behavior
timeFrame: 12 months
Other outcomes:
Locations:
city: La Réunion
country: France
facility: population générale (quartier Duparc (Sainte Marie) et Quartier Bois rouge)
Study officials:
References:
Clinical trial NCT05458726: Correlation Between Efficacy of Osimertinib and EGFR T790M Status and Ratio Via ddPCR in NSCLC
Official title: Research on the Correlation Between Efficacy of Osimertinib and EGFR T790M Status and Ratio Via Digital Droplet PCR (ddPCR) From Peripheral Blood in NSCLC Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: EGFR T790M
Osimertinib
Non-small Cell Lung Cancer
ddPCR
Lead sponsor: Peking Union Medical College
Sponsor class: OTHER
First posted: 2022-07-14
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: DIAGNOSTIC

Brief summary: Liquid biopsy is emerging as an essential tool in tumor monitoring and a potential alternative and supplement to tissue biopsy for tumor genotyping, especially in relapsed or metastatic diseases. Liquid biopsy methods for detecting T790M in ctDNA can be qualitative or quantitative, including amplification refractory mutation system PCR (ARMS-PCR), digital droplet polymerase chain reaction (ddPCR), and next generation sequencing (NGS)-based methods. Comparison of multiple detecting platform for EGFR mutations in plasma samples has been undertaken in studies to determine the most feasible assay in clinical practice. In this study, we will investigate the usefulness of ddPCR for quantitative detection of EGFR T790M mutation in peripheral blood, and compared the utility of ddPCR and NGS for guiding decisions regarding osimertinib therapy in NSCLC patients who had develop resistance to first- or second generation EGFR-TKIs.


Eligibility criteria: Inclusion Criteria:

* histologically/cytologically confirmed stage IV NSCLC patients harboring sensitizing EGFR mutations;
* progression from first or second-generation EGFR-TKI confirmed by radiographic imaging;
* received both NGS test and ddPCR from peripheral blood simultaneously.

Exclusion Criteria:

* progression from first- or second-generation EGFR-TKIs as adjuvant therapy;
* having received third-generation EGFR-TKIs prior to the gene tests;
* having received NGS test only or ddPCR test only.

Primary outcomes:
measure: PFS
timeFrame: up to 1 year
Secondary outcomes:
measure: ORR
timeFrame: up to 1 year
measure: DCR
timeFrame: up to 1 year
Other outcomes:
Locations:
city: Beijing
country: China
facility: Junling Li
state: Beijing
Study officials:
affiliation: Chinese Academy of Medical Sciences and Peking Union Medical College
name: Junling Li, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02984826: Muscle Strength in Shoulder and Neck Muscles in Tension Type Headache Patients. Effect of Specific Strength Training
Official title: Muscle Strength in Shoulder and Neck Muscles in Adult Tension Type Headache Patients, and the Effect of Specific Strength Training
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tension-Type Headache
Lead sponsor: Danish Headache Center
Sponsor class: OTHER
First posted: 2016-12-07
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Background:

Tension Type Headache (TTH) is highly frequent and is of great socio-economic importance. Andersen et al. 2008 has shown that maximal muscle strength is reduced in women with trapezius myalgia. It is shown that specific strength training leads to prolonged pain relief.

Aim:Test: To investigate the impact of TTH on shoulder, and neck muscle strength in patients with TTH compared to healthy controls.

Intervention: To investigate the effect of specific strength training on patients with TTH compared with control group, receiving training in ergonomics.

Method: Test part. 60 tension headache patients, 30 healthy. Muscle testing of neck and shoulder. Testing conducted by blinded research assistant.

Intervention group: 60 patients with tension headache randomly assigned to the intervention group or control group. Intervention with specific strength training program runs for 10 weeks. The control group will be trained in ergonomics. 3 months follow up.


Eligibility criteria: Inclusion Criteria:

* Tension-type headache(TTH), inclusion criteria were age between 18 and 65 years and for patients a diagnosis of TTH ≥8 headache days per month, and ≤3 migraine days per month according to ICHD-II -criteria.

Exclusion Criteria:

* Exclusion criteria were medication overuse headache (ICHD-II), previous whiplash or head trauma, other major physical or neurological diseases, depression, other mental illness, or being unable to understand and speak Danish. The patients were tested for cervicogenic headache according to Jull, et al 2007, and were excluded if the test was positive.

Primary outcomes:
measure: Headache frequency
timeFrame: Primary outcome headache frequency at (19-22 weeks)
measure: Headache Duration
timeFrame: Primary outcome duration of pain at (19-22 weeks)
Secondary outcomes:
measure: Intensity of headache
timeFrame: Intensity of pain at (19-22 weeks)
measure: Medication intake
timeFrame: Medication intake at (19-22 weeks)
Other outcomes:
Locations:
city: Glostrup
country: Denmark
facility: Danish Headache Center Rigshospitalet - Glostrup
Study officials:
affiliation: Danish Headache Center
name: Bjarne K K Madsen, phd stud.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Madsen BK, Sogaard K, Andersen LL, Tornoe B, Jensen RH. Efficacy of strength training on tension-type headache: A randomised controlled study. Cephalalgia. 2018 May;38(6):1071-1080. doi: 10.1177/0333102417722521. Epub 2017 Jul 27.
Clinical trial NCT01279226: Investigation of Radiofrequency Device for Treatment of Wrinkles and Rhytides
Official title: Radiofrequency Magnetic Induction Device for Use in Dermatologic Procedures for the Non-Invasive Treatment of Wrinkles and Rhytides
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Laxity of Skin
Lead sponsor: Rocky Mountain Biosystems, Inc.
Sponsor class: INDUSTRY
First posted: 2011-01-19
Enrollment: 40
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this pilot research study is to collect information on the safety and effectiveness of an experimental device intended to be used to improve the appearance of the skin by reducing the visibility of wrinkles and by reducing the looseness of skin.


Eligibility criteria: Inclusion Criteria:

* Male or female at least 21 years old,
* Apparently healthy,
* Informed consent signed by the subject.

Exclusion Criteria:

* Tobacco smokers,
* History of skin hypersensitivity,
* Current skin disorder or infection (e.g., herpes simplex),
* Prior cosmetic treatments to the face (e.g. Botox) or facial fillers (e.g. Restylane),
* Subjects with a pacemakers, internal defibrillators or electronically, magnetically, and mechanically activated implants,
* Subjects with implanted medical prostheses (such as clips, pins or plates) proximal to the treatment site,
* The current or recent use (within the past 12 months) of isotretinoin,
* Pregnancy or breast feeding,
* Insulin dependent diabetic subjects,
* Oxygen dependent subjects,
* Subjects with severe chronic illness, scleroderma, or lupus,
* Subjects with open sores or scars in the treatment region, or
* Subjects with ischemia in the treatment region.

Primary outcomes:
measure: Improved cosmesis
timeFrame: 2-6 timepoints from 4 days to 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Kirkland
country: United States
facility: Laser Treatment Center
state: Washington
Study officials:
affiliation: Laser Treatment Center
name: Peter Cooperrider, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Rocky Mountain Biosystems, Inc.
name: Stephen Flock, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01183026: V/Q SPECT for Diagnosis of Pulmonary Embolism
Official title: Performance of V/Q SPECT for the Diagnosis of Pulmonary Embolism
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pulmonary Embolism
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2010-08-17
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pulmonary embolism suspicion

Brief summary: The objective of the study was to assess diagnostic performance of V/Q SPECT for the diagnosis of pulmonary embolism by comparing V/Q SPECT results to a validated diagnostic strategy.


Eligibility criteria: Inclusion Criteria:

* Pulmonary embolism suspicion

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Le Duc-Pennec A, Le Roux PY, Cornily JC, Jaffrelot M, Delluc A, de Saint-Martin L, Guillo P, Le Gal G, Salaun PY, Leroyer C. Diagnostic accuracy of single-photon emission tomography ventilation/perfusion lung scan in the diagnosis of pulmonary embolism. Chest. 2012 Feb;141(2):381-387. doi: 10.1378/chest.11-0090. Epub 2011 Aug 18.
Clinical trial NCT01983826: Dietary Nitrates and Vascular Function in Patients With Peripheral Artery Disease
Official title: Dietary Nitrates and Vascular Function in Patients With Peripheral Artery Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Peripheral Artery Disease
Keywords: nitrates
blood flow
vascular function
exercise
Lead sponsor: University of Iowa
Sponsor class: OTHER
Collaborators: name: American Heart Association
First posted: 2013-11-14
Enrollment: 21
Sex: ALL
Minimum age (years): 50
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The overarching question addressed in the current project is: Does dietary nitrate supplementation (8 weeks) improve physiological function in patients with peripheral arterial disease (PAD)? The investigators will specifically address whether dietary nitrate supplementation enhances blood vessel function, blood pressure regulation, and exercise capacity. The proposed project uses an array of clearly defined measurements which will allow investigators to quantify blood vessel function (vasodilator responsiveness and arterial stiffness), blood pressure (variability and responsiveness to stress), and functional capacity before and after 8 weeks of dietary supplementation.


Eligibility criteria: Inclusion Criteria:

* Documented peripheral artery disease
* Ankle-Brachial Index (ABI) \< or = to 0.90

Exclusion Criteria:

* Non-atherosclerotic vascular disease
* Critical limb ischemia
* Active ischemic ulceration
* Recent (within one year) revascularization
* Symptomatic coronary artery disease (angina pectoris)
* Heart failure
* Resting systolic blood pressure \> 180 mmHg or diastolic pressure \> 100 mmHg
* Hypotension (resting systolic BP \< 90 mmHg)
* Smoking or history of smoking within past one year
* Use of phosphodiesterase V inhibitor drugs
* Women with history of hormone replacement therapy within the past 6 months

Primary outcomes:
measure: Change in Vasodilator Capacity
timeFrame: Pre and post 8 weeks of dietary nitrate supplementation
measure: Change in Arterial Stiffness
timeFrame: Pre and post 8 weeks of dietary nitrate supplementation
measure: Change in Functional Capacity - Distance Walked in 6 Minutes
timeFrame: Pre and post 8 weeks of dietary nitrate supplementation
Secondary outcomes:
Other outcomes:
Locations:
city: Iowa City
country: United States
facility: University of Iowa
state: Iowa
Study officials:
affiliation: University of Iowa
name: Darren P Casey, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hughes WE, Treichler DP, Ueda K, Bock JM, Casey DP. Sodium nitrate supplementation improves blood pressure reactivity in patients with peripheral artery disease. Nutr Metab Cardiovasc Dis. 2022 Mar;32(3):710-714. doi: 10.1016/j.numecd.2021.12.002. Epub 2021 Dec 8.
Clinical trial NCT05421026: Cyberbullying Among Sohag University Student
Official title: Cyberbullying Among Sohag University Students , Egypt .
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cyberbullying Among Sohag University Students
Keywords: cyberbullying
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2022-06-16
Enrollment: 500
Sex: ALL
Minimum age (years): 17
Maximum age (years): 25
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: The sample was taken by the mean of cluster random sampling technique among all sohag faculties. Four faculties were chosen; Two practical faculties and two theoritical faculties . Then a suitable random sample will be taken from the students of the determined faculties.

Brief summary: Cyberbullying can be defined as intentional aggression through electronic routes, such as text messages, e-mails, chat rooms, online games, and social websites. In comparison with traditional bullying, cyberbullying has many unique characteristics that boost its harmful effects, including the inability to avoid bullying, presence of larger and more potential audience, the continuity of bullying regardless of time or place, and the anonymity of perpetrator in many occasions .

Detailed description: In Egypt almost half of Beni-sueif university students (48.2%) reported experiencing cyberbullying victimization. Female students, students living in urban areas and those who spent more hours using the internet reported more exposure (p\<0.001). Harassment was the main type stated by females (79.8%) while flaming was excessively reported by males (51.8%). Students responded mostly by anger (63.1%), hatred (23.2%) and sorrow (22.6%) towards the worst victimization incidents.

In this study I want to study the situation of cyberbullying among Sohag University students .

, study patterns of cyberbullying among Sohag University students , determine of correlates of cyberbullying among Sohag University students such as family factors and study the implications of cyberbullying on victims .

Eligibility criteria: Inclusion Criteria:

* students of the selected faculties

Exclusion Criteria:

* students who will refuse to participate in this study.

Primary outcomes:
measure: study the situation of cyberbullying among Sohag University students
timeFrame: 2022-2023
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02104726: "Blind" vs. Fluoroscopy-Guided Steroid Injections for Knee Osteoarthritis
Official title: Prospective Randomized-Controlled Two-Arm Study of "Blind" vs. Fluoroscopy-Guided Steroid Injections for Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Osteoarthritis
Lead sponsor: Johns Hopkins University
Sponsor class: OTHER
First posted: 2014-04-04
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare relative efficacy of intraarticular steroid injection using anatomic landmarks vs. fluoroscopy guided technique in decreasing knee osteoarthritis pain 1 month after the procedure.


Eligibility criteria: Inclusion Criteria:

- Adults with knee OA clinically deemed to qualify for steroid injection

Exclusion Criteria:

- Children Non-English Speakers Pregnant

Primary outcomes:
measure: Numerical Rating Scale (pain)
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05941026: Developing Nursing Students' Intercultural Sensitivity Levels
Official title: Developing Nursing Students' Intercultural Sensitivity Levels: A Randomized Controlled Experimental Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nursing Caries
Education
Keywords: Nursing
Student
Culture
Intercultural
Sensitivity
Education
Lead sponsor: Aydin Adnan Menderes University
Sponsor class: OTHER
First posted: 2023-07-12
Enrollment: 117
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Following recruitment, students were divided into a study and a control group by randomization (1:1 randomization)
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study; This is a randomized controlled experimental type study designed to improve the intercultural sensitivity levels of nursing students.

Detailed description: Cultural sensitivity is extremely important for healthcare professionals. Understanding cultural differences can help build a trusting relationship between patients and healthcare professionals. This increases patient satisfaction and improves the quality of health services.

This work; This is a randomized controlled experimental type study designed to improve the intercultural sensitivity levels of nursing students.

Intercultural sensitivity training does not affect the intercultural sensitivity level of nursing students.

Eligibility criteria: Inclusion Criteria:

* Being a student of Aydın Adnan Menderes University Nursing Department
* Having successfully completed the basic practical courses of the first three classes
* Being enrolled in one of the Public Health Nursing or Mental Health and Diseases Nursing courses from the fourth year
* Volunteer to participate in the study

Exclusion Criteria:

• Not completing the training sessions of the research

Primary outcomes:
measure: Intercultural Sensitivity Scale and Personel Questions
timeFrame: Pre-test (Before the training)
measure: Intercultural Sensitivity Scale
timeFrame: four weeks after the pre-test (at the end of the training)
measure: Intercultural Sensitivity Scale
timeFrame: eight weeks after the pre-test (and one month after the training)
Secondary outcomes:
Other outcomes:
Locations:
city: Aydın
country: Turkey
facility: Aydın Adnan Menderes University Institute of Health Sciences Department of Public Health Nursing
Study officials:
affiliation: Aydın Adnan Menderes University Institute of Health Sciences Department of Public Health Nursing
name: Öner ALTINTOP, MsC
role: STUDY_CHAIR
References:
Clinical trial NCT00439426: A Study of Xeloda (Capecitabine) in Combination With XELOX (Oxaliplatin) in Patients With Metastatic Nasopharyngeal Cancer.
Official title: An Open Label Study of First Line Chemotherapy With Xeloda in Combination With Cisplatin on Treatment Response in Patients With Metastatic Nasopharyngeal Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Nasopharyngeal Cancer
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2007-02-23
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This single arm study will assess the efficacy and safety of Xeloda + oxaliplatin when given as first line treatment for patients with metastatic nasopharyngeal cancer. Patients will receive Xeloda (1000mg/m2 bid orally from day 1 to day 14, followed by a rest period of 7 days) plus oxaliplatin (130mg/m2 iv infusion on day 1 of each 21 day cycle) for 6-8 cycles. The anticipated time on study treatment is until disease progression, and the target sample size is \<100 individuals.


Eligibility criteria: Inclusion Criteria:

* adult patients, 18-75 years of age;
* history of nasopharyngeal cancer and distant metastases;
* no previous chemotherapy in past 6 months;
* recovery from previous radiotherapy;
* ability to swallow and retain oral medication.

Exclusion Criteria:

* previous cytotoxic chemotherapy;
* radiotherapy within 4 weeks of treatment start;
* history of another malignancy within the last 5 years;
* clinically significant cardiac disease.

Primary outcomes:
measure: Overall response rate
timeFrame: Event driven
Secondary outcomes:
measure: Time to disease progression or death, survival time, duration of response, complete response rate.
timeFrame: Event driven
measure: AEs, laboratory parameters.
timeFrame: Throughout study
Other outcomes:
Locations:
city: Agadir
country: Morocco
city: Casablanca
country: Morocco
city: Marrakech
country: Morocco
city: Rabat
country: Morocco
city: Rabat
country: Morocco
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
References: