louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04690101: Treatment of Choledocolithiasis by Laparoscopic Exploration
Official title: Treatment of Choledocolithiasis by Laparoscopic Exploration of The Bile Tract After Failed Endoscopic Cholangiopancreatography
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Choledocholithiasis
Lead sponsor: Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Sponsor class: OTHER_GOV
First posted: 2020-12-30
Enrollment: 75
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_CROSSOVER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with a diagnosis of cholecyto-choledocholithiasis with failed ERCP and who were taken to LCDE in the General Surgery service of the General Ignacio Zaragoza

Brief summary: There are three treatment options for choledocholithiasis: endoscopic retrograde cholangiopancreatography (ERCP) followed by laparoscopic cholecystectomy; laparoscopic exploration of the main bile duct with concomitant cholecystectomy; and open cholecystectomy with exploration of the main bile duct. A retrospective, descriptive, observational study was taken of patients with a diagnosis of cholecystocholedocholithiasis that failed ERCP and who underwent laparoscopic cholecystectomy with exploration of the bile duct.

Detailed description: this study was revision of clinical files.

Eligibility criteria: Inclusion Criteria:

* Patients with a diagnosis of cholecyto-choledocholithiasis with failed ERCP and who were taken to LCDE in the General Surgery service

Exclusion Criteria:

* Less than 18 year old

Primary outcomes:
measure: TREATMENT OF CHOLEDOCOLITHIASIS
timeFrame: 2009-2018
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04184401: Effect of Ascites Replacement Strategy on Time to 1st Flatus After LDLT
Official title: Effect of Albumin Administration Strategy for Ascites Replacement on Time to 1st Flatus After Liver Transplantation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Living Donor Liver Transplantation
Keywords: Ascites
Albumin
Hartmann's solution
Postoperative ileus
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: GC Pharma
First posted: 2019-12-03
Enrollment: 72
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of this study is to evaluate difference in the rate of recovery of intestinal motility according to different ascites replacement strategy after living donor liver transplantation.


Eligibility criteria: Inclusion Criteria:

* Adults (19 years or older)
* Elective living donor liver transplantation

Exclusion Criteria:

* Previous abdominal surgery
* Renal failure requiring renal replacement therapy
* Contraindications for 5% albumin use

  1. Condition with potential risk caused by increased circulating plasma (heart failure, renal failure combined with oliguria, pulmonary edema)
  2. Hemolytic anemia
* Contraindications for Hartmann solution

  1. Progressive lactic acidosis
  2. Hypervolemia
  3. Hypernatremia

Primary outcomes:
measure: Time to 1st flatus
timeFrame: within 4 weeks
measure: Time to 1st diet
timeFrame: within 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: Ho Geol Ryu, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00209001: Efficacy of Acupuncture for Hot Flashes in Women Treated With Hormonal Therapy for Breast Cancer
Official title: Efficacy of Acupuncture for Hot Flashes in Women Treated With Hormonal Therapy for Breast Cancer
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Breast Cancer
Keywords: Breast Cancer
Lead sponsor: Emory University
Sponsor class: OTHER
First posted: 2005-09-21
Enrollment: 7
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine if acupuncture is effective in relieving hot flashes in women treated with hormonal therapy for breast cancer.

Detailed description: The purpose of this study is to determine if acupuncture is effective in relieving hot flashes in women treated with hormonal therapy for breast cancer.

Hormonal therapy is one of the most common treatments for breast cancer in women. Unfortunately, many women on hormonal therapy suffer from hot flashes (the sudden sensation of heat throughout the face, neck and chest, with or without shivering and sweating). Many medicines have been used to treat hot flashes, but no single medication has been found to work reliably.

Acupuncture has been shown to be effective for many conditions in Western medicine specifically for dry mouth in people who have received radiation to their head and neck, as well as for hot flashes in women during menopause (the "change of life"). In this study, we are investigating whether acupuncture is effective for women suffering hot flashes that result from their treatment of breast cancer.

Eligibility criteria: Inclusion Criteria:

* Female
* 18 years of age or older
* History of breast cancer who have received hormonal therapy
* Personal history of hot flashes
* Patients will be accepted if receiving therapy with traditional allopathic medicines if their hot flashes have persisted after two months

Exclusion Criteria:

* Receiving therapy with traditional allopathic medicines for hot flashes

Primary outcomes:
measure: Define efficacy of acupuncture to points of the enhanced Ming Men technique for relief of hot flashes after hormonal therapy for breast cancer.
timeFrame: weekly evaluation up to 9 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Atlanta
country: United States
facility: Emory University Winship Cancer Institute
state: Georgia
Study officials:
affiliation: Emory University Winship Cancer Institute
name: Peter Johnstone, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03707301: Post-SOPHrology Cancer Patients' anxieTY Report
Official title: Post-SOPHrology Cancer Patients' anxieTY Report
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Cancer
Keywords: Cancer
Sophrology
Anxiety
Hospital Anxiety and Depression scale
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
Collaborators: name: Institut de Cancérologie de la Loire
First posted: 2018-10-16
Enrollment: 17
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cancer patients performing sophrology sessions at the Lucien Neuwirth Cancer Institute will be recuited in this study.

Brief summary: Cancer is pathology with a high impact on patients and relatives quality of life. Most of the time, it is a stressful trial. Professionals have often resort to pharmaceutical solutions, but sometimes, it is not sufficient. So, patients resort to alternative and complementary medicines, as sophrology. In Lucien Neuwirth Cancer Institute, patients can benefit from sophrology.

Anxiety levels have never been reported before and after sessions. Indeed, the present study wants to report anxiety levels before, after, and one and three weeks after session. Levels of satisfaction will also be reported.

Detailed description: Cancer is pathology with a high impact on patients and relatives quality of life. Most of the time, it is a stressful trial. Professionals have often resort to pharmaceutical solutions, but sometimes, it is not sufficient. So, patients resort to alternative and complementary medicines, as sophrology. In Lucien Neuwirth Cancer Institute, patients can benefit from sophrology.

Anxiety levels have never been reported before and after sessions. Indeed, the present study wants to report anxiety levels before, after, and one and three weeks after session. Levels of satisfaction will also be reported.

Eligibility criteria: Inclusion Criteria:

- Patient performing at least one session of sophrology in the Lucien Neuwirth Cancer Institute

Exclusion Criteria:

* Protected patient (according to the law),
* Patient with incapacity to complete questionnaires,
* Patient with incapacity to perform sophrologic movements.

Primary outcomes:
measure: Level of anxiety difference
timeFrame: 1 hour
Secondary outcomes:
measure: Level of anxiety difference
timeFrame: 1 month
measure: Level of depression difference
timeFrame: 1 month
measure: Sessions duration
timeFrame: 1 hour
measure: Number of sessions
timeFrame: 1 month
measure: Patients satisfaction
timeFrame: 1 month
Other outcomes:
Locations:
city: Saint-Priest-en-Jarez
country: France
facility: Institut de Cancérologie Lucien Neuwirth
Study officials:
affiliation: Institut de Cancérologie Lucien Neuwirth
name: Stéphanie Morisson, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02671201: Training Concepts in Emergency Ultrasonography
Official title: Training Concepts in Emergency Ultrasonography for Medical Students
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Medical Education in Emergency Ultrasound
Lead sponsor: University of Cologne
Sponsor class: OTHER
First posted: 2016-02-02
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Undergraduate medical students

Brief summary: Emergency ultrasound examinations are increasingly important diagnostic tools in emergency and critical care medicine. This study wants to analyze different types of education for undergraduate students. Any method of medical training will be proved theoretical and in clinical practice.

Detailed description: This prospective educational study wants to analyze different methods of education for undergraduate medical students.

Method A: Theoretical training will be scheduled for 2 hours with lectures in basics of emergency ultrasound. After the theoretical education the students will obtain a bedside-teaching on intensive care unit for 4 hours.

Method B: Theoretical training will be scheduled for 3 hours and included lectures in echocardiography, lung ultrasound and abdominal ultrasound. After the theoretical education the students will obtain a bedside-teaching on intensive care unit for 3 hours.

Method C: Theoretical training will be scheduled for 3 hours and included lectures in echocardiography, lung ultrasound and abdominal ultrasound. After the theoretical education the students will obtain a hands-on-training in healthy volunteers for 3 hours. The acquired knowledge and practical skills will be analyzed by a multiple-choice exam (5 MC-questions, 5 video sequences) and a practical exam (five tasks).

Any method of training will be proved at the end theoretical and in clinical practice.

Eligibility criteria: Inclusion Criteria:

* Medical students

Exclusion Criteria:

* No

Primary outcomes:
measure: Improvement of the knowledge score with different training in emergency ultrasound
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Cologne
country: Germany
facility: Prof. Dr. Guido Michels
Study officials:
affiliation: Univesity of Cologne, Germany
name: Guido Michels, Prof. Dr.
role: STUDY_CHAIR
References:
Clinical trial NCT02584101: Acceptance and Commitment Therapy (ACT) and Carers
Official title: The Use of Acceptance and Commitment Therapy to Promote WellBeing and Psychological Flexibility in Carers: A Randomized Controlled Feasibility Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Brain Injuries
Keywords: Acceptance and Commitment Therapy
Lead sponsor: University of Glasgow
Sponsor class: OTHER
Collaborators: name: Brain Injury Rehabilitation Trust
First posted: 2015-10-22
Enrollment: 18
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Background: Research has extensively documented the adverse impact that caring for an individual with an acquired brain injury can have including financial difficulties, social isolation, family tension and conflict, relationship difficulties, role adjustment and psychological distress (Foster et al., 2012). Research has indicated that Acceptance and Commitment Therapy (ACT) shows promise for increasing wellbeing and psychological flexibility in caregivers and could be a useful intervention for use with this population.

Aims: The primary aim of this study is to investigate the feasibility of using an ACT intervention to enhance the wellbeing and the psychological flexibility of carers using the Population, Intervention, Control, and Outcomes (PICO) framework. Methods: The current study is a randomised control design, exploring the feasibility of comparing the efficacy of an ACT intervention to Enhanced Treatment As Usual (ETAU), to improve the wellbeing of the carers of adults with an acquired brain injury (ABI). Participants will be recruited from the Brain Injury Rehabilitation Trust (BIRT) in Glasgow, Scotland and randomly assigned to either an ACT intervention group or TAU control group. Both will be assessed in parallel to one another completing a range of baseline and post-baseline measures. Applications: This feasibility study will provide information for further research on the utilisation of an ACT intervention to improve the wellbeing of carers and whether this is an acceptable intervention for this population.


Eligibility criteria: Inclusion Criteria:

* full time or part time carer for an adult with an acquired brain injury

Exclusion Criteria:

* learning disability
* not proficient in English

Primary outcomes:
measure: Well-being
timeFrame: 4 weeks
Secondary outcomes:
measure: Psychological Flexibility
timeFrame: 4 weeks
measure: Values
timeFrame: 4 weeks
measure: Experiential Avoidance
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Glasgow
country: United Kingdom
facility: Brain Injury Rehabilitation Trust
Study officials:
affiliation: University of Glasgow
name: Ross White, BSc(Hons) PhD DClinPsy
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05038501: Prevalence of Comorbidities in Patients Undergoing Oncosurgeries at Tertiary Cancer Institute in North India.
Official title: Prevalence of Comorbidities in Patients Undergoing Oncosurgeries at Tertiary Cancer Institute in North India
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Comorbidities and Coexisting Conditions
Keywords: comorbidities
oncosurgery
Lead sponsor: Rajiv Gandhi Cancer Institute & Research Center, India
Sponsor class: OTHER
First posted: 2021-09-09
Enrollment: 150
Sex: ALL
Minimum age (years): 35
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients undergoing Oncosurgeries will be studied for prevalence of comorbidites.

Brief summary: Investigators plan to study the prevalence of comorbidities in patients undergoing oncosurgeries

Detailed description: Plan to study the prevalence of Coronary Artery Disease, Hypertension, Diabetes Mellitus, Hypothyroidism, History of Corona Virus infection in patients undergoing oncosurgeries.

In the Pre anesthesia checkup patients age , sex , Weight in kilograms, Height in centimeters , pulse rate, Blood Pressure will be noted and value\>140/90 mmHg will be taken as hypertensive. History will be obtained about diagnosed Coronary Artery Disease , Diabetes Mellitus, Hypertension , Hypothyroidism , History of previous Corona Virus Infection (RT-PCR Test Positive) .Relevant investigations Electrocardiography and Echocardiography for assessment of Coronary Artery Disease. Fasting or Random Blood Sugar , Thyroid Function Test will be done .

Fasting Blood Sugar \>126 milligram/ Decilitre and Random Blood sugar \>200mg/dL will be taken as diabetic. TSH more than 5 micro IU/mL will be hypothyroid .

Eligibility criteria: Inclusion Criteria: Patients undergoing Oncosurgeries Age above 40 years .

-

Exclusion Criteria:

Age below 40 years Emergency Surgery Patient Refusal

Primary outcomes:
measure: To study Coronary Artery disease in patients undergoing Oncosurgeries
timeFrame: 60 days
measure: To study Diabetes Mellitus in patients undergoing Oncosurgeries.
timeFrame: 60days
Secondary outcomes:
measure: To study Hypothyroidism in patients undergoing Oncosurgeries
timeFrame: 60 days
Other outcomes:
Locations:
city: Delhi
country: India
facility: Anita Kulkarni
Study officials:
affiliation: Rajiv Gandhi Cancer Institute and RC , Delhi, INDIA
name: Anita Kulkarni, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gupta R, Mohan I, Narula J. Trends in Coronary Heart Disease Epidemiology in India. Ann Glob Health. 2016 Mar-Apr;82(2):307-15. doi: 10.1016/j.aogh.2016.04.002.
citation: Ranasinghe P, Jayawardena R, Gamage N, Sivanandam N, Misra A. Prevalence and trends of the diabetes epidemic in urban and rural India: A pooled systematic review and meta-analysis of 1.7 million adults. Ann Epidemiol. 2021 Jun;58:128-148. doi: 10.1016/j.annepidem.2021.02.016. Epub 2021 Mar 13.
Clinical trial NCT00076401: A Study of Motexafin Gadolinium for the Treatment of Chronic Lymphocytic Leukemia (CLL)
Official title: Phase II Trial of Motexafin Gadolinium (MGd) in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
Conditions: Leukemia
Leukemia, Lymphocytic, Chronic
Keywords: CLL
chronic lymphocytic leukemia
relapsed chronic lymphocytic leukemia
refractory chronic lymphocytic leukemia
Leukemia
Motexafin gadolinium
Chronic leukemia
Lymphocytic leukemia, chronic
Lead sponsor: Pharmacyclics LLC.
Sponsor class: INDUSTRY
First posted: 2004-01-26
Enrollment: 27
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine if the drug motexafin gadolinium will be an effective treatment for patients who have chronic lymphocytic leukemia (CLL) that has come back after treatment or that has stopped responding to treatment.


Eligibility criteria: Inclusion Criteria:

* At least 18 years old
* Refractory or relapsed CLL
* ECOG performance status score of 0, 1, or 2
* Each patient must sign a study-specific informed consent form

Exclusion Criteria:

Laboratory values of:

* Platelet count \<30,000/uL
* AST or ALT \>2 x the upper limit of normal (ULN)
* Total bilirubin \>2 x ULN
* Creatinine \>2.0 mg/dL
* Chemotherapy, radiation therapy, immunotherapy, systemic corticosteroids, or systemic biologic anticancer therapy within 21 days before beginning study treatment
* Women who are pregnant or lactating

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Columbus
country: United States
facility: Ohio State University Medical Center
state: Ohio
Study officials:
References:
Clinical trial NCT04623801: Laser Ablation of Papillary Thyroid Microcarcinoma
Official title: Pilot Study to Evaluate the Safety and Efficacy of Percutaneous Laser Ablation of Thyroid Papillary Microcarcinoma
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE2
Conditions: Papillary Thyroid Microcarcinoma
Thyroid
Thyroid Cancer
Keywords: PTMC
Papillary Thyroid Microcarcinoma
Thyroid Cancer
Percutaneous Laser Ablation
PLA
19-438
Memorial Sloan Kettering Cancer Center
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
First posted: 2020-11-10
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to explore whether percutaneous laser ablation (PLA) is a safe and effective alternative to removing papillary thyroid microcarcinoma (PTMC) with surgery.


Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years
* Papillary thyroid cancer documented by

  * (a) Bethesda VI cytology,
  * (b) Bethesda III, IV, V, or VI cytology AND BRAF V600E mutation, or
  * (c) Bethesda V cytology AND high risk ultrasonographic features documented by either the ATA high suspicion or TIRADS 5 nodule characteristics

To ensure the majority of cases will be eligible based on criteria (a) or (b), we will enroll ≤ 2 patients based on criteria (c).

* Maximum diameter ≤ 13 mm
* Declined active surveillance
* The thyroid lesion must be primarily solid with ≤ 25% cystic compent
* No US evidence of extrathyroidal extension through the thyroid capsule
* No imaging evidence of lymph node metastasis
* Preserved contralateral vocal cord function prior to PLA

Exclusion Criteria:

* Thyroid cancer that is non papillary thyroid cancer (PTC)
* Thyroid lesion with \> 25% cystic component
* Lesion with US evidence of extrathyroidal extension through the thyroid capsule
* Clinical or ultrasonographic evidence of lymph node metastasis
* Pregnancy

Primary outcomes:
measure: Number of participants with complete thermal ablation
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: R. Michael Tuttle, MD
role: PRINCIPAL_INVESTIGATOR
References: