Clinical trial NCT06437691: Effect of Stent Placement on Short Term Survival of Left Sided Obstructive Colorectal Cancers
Official title: Effect of Stent Placement on Short Term Survival of Left Sided Obstructive Colorectal Cancers. Comparison of Bridge-To-Surgery Versus Emergency Surgery Approaches
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Colorectal Cancer
Keywords: Obstruction, Bridge To Surgery
Lead sponsor: Kanuni Sultan Suleyman Training and Research Hospital
Sponsor class: OTHER
First posted: 2024-05-31
Enrollment: 65
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients come to emergency department and diagnosed as left sided obstructive colorectal cancer

Brief summary: The aim of this observational study is to determine effect of stent placement on survival results in first three years in a patient who applied to the emergency department with obstruction due to colorectal cancer. Eligible patients divided into two groups. Group A includes patients underwent emergency surgery directly. Patients underwent elective surgery following stent placement as bridge-to-surgery. Patients underwent elective surgery following bridge-to-surgery stent placement were accepted as Group B.

Detailed description: Patients who applied to emergency department of a single tertiary referral center between January 2016 and December 2020 and diagnosed as left sided obstructive colorectal cancer were included in this retrospective study. All patients were equal or older than 18 years and histopathologically found to have primary colorectal malignant neoplasms.

Patients were excluded from the analysis if they met any of the following criteria:

* Who underwent emergency surgery due to unsuccessful stent application intervention or stent-related complications developed,
* Those with middle and lower rectum tumors or received neoadjuvant treatment,
* Perforation,
* Who underwent subtotal or total colectomy (as a result of colon ischemia in the cecum, microperforation, etc.),
* Recurrent disease patients
* Patients have metastasis

Eligibility criteria: Inclusion Criteria:

* All patients were equal or older than 18 years and histopathologically found to have primary colorectal malignant neoplasms and diagnosed as left sided (descending colon, sigmoid colon and upper rectum) obstructive colorectal cancer were included

Exclusion Criteria:

* Who underwent emergency surgery due to unsuccessful stent placement intervention
* Who underwent emergency surgery due to stent-related complications
* Those with middle and lower rectum tumors
* Those received neoadjuvant treatment,
* Patients have perforation,
* Who underwent subtotal or total colectomy (as a result of colon ischemia in the cecum, microperforation, etc.),
* Who has a recurrent disease or metastasis.

Primary outcomes:
measure: Overall Survival
timeFrame: 3 years
measure: Disease Free Survival
timeFrame: 3 years
Secondary outcomes:
measure: Mortality
timeFrame: 90 days
measure: Serious complications
timeFrame: 90 days
measure: Minimally invasive surgery
timeFrame: 90 days
measure: End colostomy rate
timeFrame: 90 days
Other outcomes:
Locations:
Study officials:
affiliation: Bakırköy Dr. Sadi Konuk Training and Research Hospital
name: Ahmet Sürek
role: STUDY_CHAIR
References: