Clinical trial NCT02282748: Swiss Longitudinal Cohort
Official title: Swiss Longitudinal Cohort
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cardiovascular Risk Factors
Lead sponsor: Hypertension Excellence Centre Lucerne
Sponsor class: OTHER
First posted: 2014-11-04
Enrollment: 1000
Sex: ALL
Minimum age (years): 6
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Population of four Swiss municipalities

Brief summary: The planned research project is a prospective population-based cohort study, similar to the well-known Framingham study in the United States. So far, there is no similar research project in Switzerland.

It is planned to examine of three Swiss municipalities. Recruitment in a first Swiss municipality (Lostallo/Cama GR) started 2014 and ended in 2019. Overall, 496 participants were recruited in this municipality. The five-year follow-up in this municipality started in 2019. It is planned to start recruitment in a second Swiss municipality (Uznach SG) in 2020.

The examinations embrace a broad spectrum of measurements (for details the investigators refer to the published study protocol).


Eligibility criteria: Inclusion Criteria:

* Resident of Cama GR, Lostallo GR, or Uznach SG
* Age ≥6 years (no upper age limit), for voluntary blood sample ≥18 years
* Willing to participate in long-term study
* Written informed consent (in participants ≥6 years and \<18 years signed by parents)

Exclusion Criteria:

* No exclusion criteria

Primary outcomes:
measure: Mortality
timeFrame: 10 years
Secondary outcomes:
measure: Cardiovascular events
timeFrame: 10 years
measure: Heart function
timeFrame: 10 years
measure: Cognitive function
timeFrame: 10 years
measure: Kidney function
timeFrame: 10 years
measure: Autonomy
timeFrame: 10 years
measure: Nursing home admission
timeFrame: 10 years
Other outcomes:
measure: Changes in cardiovascular risk factors
timeFrame: 10 years
Locations:
city: Cama
country: Switzerland
facility: Cama
state: Graubünden
city: Lostallo
country: Switzerland
facility: Lostallo
state: Graubünden
city: Uznach
country: Switzerland
facility: Linth Hospital
state: Saint Gallen
Study officials:
affiliation: Hypertension Excellence Centre Lucerne
name: Paul Erne, MD
role: STUDY_CHAIR
affiliation: University Department of Geriatrics, University of Bern
name: Andreas W Schoenenberger, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Zurich
name: Paolo Suter, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Swiss Society of Hypertension
name: Franco Muggli, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hypertension Excellence Centre Lucerne
name: Renate Schoenenberger, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Linth Hospital
name: Pierre-Alexandre Krayenbühl, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Pusterla L, Radovanovic D, Muggli F, Erne P, Schoenenberger AW, Schoenenberger-Berzins R, Parati G, Suter P, Lava SAG, Gallino A, Bianchetti MG. Impact of Cardiovascular Risk Factors on Arterial Stiffness in a Countryside Area of Switzerland: Insights from the Swiss Longitudinal Cohort Study. Cardiol Ther. 2022 Dec;11(4):545-557. doi: 10.1007/s40119-022-00280-8. Epub 2022 Sep 24.
citation: Schoenenberger AW, Radovanovic D, Muggli F, Suter PM, Schoenenberger-Berzins R, Parati G, Bianchetti MG, Gallino A, Erne P. Prevalence of ideal cardiovascular health in a community-based population - results from the Swiss Longitudinal Cohort Study (SWICOS). Swiss Med Wkly. 2021 Sep 28;151:w30040. doi: 10.4414/smw.2021.w30040. eCollection 2021 Sep 27.
citation: Schoenenberger AW, Muggli F, Parati G, Gallino A, Ehret G, Suter PM, Schoenenberger-Berzins R, Resink TJ, Erne P. Protocol of the Swiss Longitudinal Cohort Study (SWICOS) in rural Switzerland. BMJ Open. 2016 Nov 28;6(11):e013280. doi: 10.1136/bmjopen-2016-013280.