Clinical trial NCT02721030: Mbarara Acute Heart Failure Registry
Official title: Mbarara Acute Heart Failure Registry: Opportunities to Improve Care of Patients Hospitalized With Acute Decompensated Heart Failure in Mbarara Regional Referral Hospital, Uganda
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Heartfailure
Keywords: Heartfailure
1-year mortality
heartfailure quality of life
sub-Saharan Africa
Lead sponsor: Mbarara University of Science and Technology
Sponsor class: OTHER
Collaborators: name: University of Virginia
name: Abbott Point of Care
First posted: 2016-03-28
Enrollment: 217
Sex: ALL
Minimum age (years): 13
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Target Population: Patients hospitalized in a medical ward of a resource poor setting.

Accessible Population: Patients aged 13 years or more admitted with a diagnosis of acute decompensated Heart failure to the Medical ward of Mbarara Regional Referral Hospital.

Brief summary: This is a prospective cohort to describe clinical characteristics, predictors of poor outcomes both during hospitalization and at home, functional status, and quality of life among patients aged 13 years or more, consecutively admitted with acute decompensated heart failure at Mbarara Regional Referral Hospital.

Detailed description: This is a prospective observational cohort study to collect comprehensive data of heartfailure patients during and after hospitalization for acute heart failure at Mbarara Regional Referral Hospital (MRRH), Uganda. The investigators will collect sociodemographic, clinical, quality of life, functional status, and clinical cardiovascular disease measures during hospitalization and follow up for up to 1 year from the date of enrollment.

Eligibility criteria: Inclusion Criteria:

* Patients admitted with a confirmed clinical diagnosis of acute heartfailure aged 13 years or above at Mbarara Regional Referral Hospital, Uganda

Exclusion Criteria:

* Body swelling from kidney disease, liver disease or malnutrition.
* Acute kidney disease with no previous history/documentation of heart disease.
* History suggestive of chronic kidney disease with no previous history/documentation of heart disease.
* History suggestive of chronic liver disease with no previous history/documentation of heart disease.

Primary outcomes:
measure: All-cause mortality
timeFrame: 1 year
Secondary outcomes:
measure: Length of hospitalization
timeFrame: 1 year
measure: Quality of life using the SF-36 questionnaire
timeFrame: 1 year
measure: Functional status using the Kansas city cardiomyopathy questionnaire
timeFrame: 1 year
Other outcomes:
Locations:
city: Mbarara
country: Uganda
facility: Mbarara Regional Referral Hospital
state: N/A = Not Applicable
Study officials:
affiliation: Mbarara University of Science & Technology
name: Charles Fardous, MMED
role: STUDY_DIRECTOR
References:
citation: Abeya FC, Lumori BAE, Akello SJ, Annex BH, Buda AJ, Okello S. Incidence and predictors of 6 months mortality after an acute heart failure event in rural Uganda: The Mbarara Heart Failure Registry (MAHFER). Int J Cardiol. 2018 Aug 1;264:113-117. doi: 10.1016/j.ijcard.2018.03.110. Epub 2018 Mar 29.