louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06151860: Acute Effect of Static Stretching and Pilates Stretching on the Muscle Strength
Official title: Acute Effect of Static Stretching and Pilates Stretching on the Concentric Muscle Strength of the Knee Extensors and Flexors
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Muscle Strength
Muscle Strength Dynamometer
Lead sponsor: Universidade Estadual do Norte do Parana
Sponsor class: OTHER
First posted: 2023-11-30
Enrollment: 102
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Introduction: Studies have shown that static stretching performed immediately before strength exercises impairs performance. However, unlike static stretching, dynamic stretching performed immediately before muscular strength exercises does not seem to result in worse performance, and in some cases may even provide greater strength performance. Still, the literature is controversial and inconclusive to date.

Objective: To verify the acute effect of static stretching versus dynamic stretching on the muscle strength of young university students.

Methods: The sample will consist of 102 physically active young university students, of both sexes, aged between 18 and 25 years old, subdivided into three groups: Group 1 - static stretching; Group 2 - dynamic stretching; and Group 3 - control. Everyone will undergo assessment of the isokinetic peak torque of the knee extensor and flexor muscles at 60º/s and 180º/s in the dominant lower limb. Next, the experimental groups (Groups 1 and 2) will perform static or dynamic stretching exercises for the quadriceps and hamstring muscles, while the control group will not perform any activity. Finally, everyone will undergo muscle strength assessment again according to the same procedures used initially. Analysis of covariance (ANCOVA) will be used to compare groups, with data from the initial assessment as adjustment covariates.


Eligibility criteria: Inclusion Criteria:

* to practice systematic physical exercises at least three times a week over the last six months;
* healthy young adults, aged between 18 and 25 years;
* agree to participate in the study by signing the Free and Informed Consent Form.

Exclusion Criteria:

* musculoskeletal injuries in the lower limbs;
* pregnancy.

Primary outcomes:
measure: Muscle strength
timeFrame: Acute (immediate) effect: pre-intervention and post-intervention (10 minutes after pre-intervention)
Secondary outcomes:
Other outcomes:
Locations:
city: Jacarezinho
country: Brazil
facility: Universidade Estadual do Norte do Paraná
state: Paraná
Study officials:
References:
Clinical trial NCT01799460: Study on Single-nucleotide-polymorphism in Idiopathic Membranous Nephropathy
Official title: Mechanism Research of Traditional Chinese Medicine (the Comprehensive Treatment Regimen) in Treating Idiopathic Membranous Nephropathy by Genomewide Association Studies
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Idiopathic Membranous Nephropathy
Keywords: single-nucleotide-polymorphism
Traditional Chinese Medicine
the Comprehensive Treatment Regimen
Lead sponsor: Shanghai University of Traditional Chinese Medicine
Sponsor class: OTHER
First posted: 2013-02-26
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: idiopathic membranous nephropathy

Brief summary: The purpose of this study is to analysis the different genotype in the idiopathic membranous nephropathy patients which with different therapeutic outcomes after treated by the Comprehensive Treatment Regimen or immunosuppressive agents, and so as to looking for ideal markers to assess appropriate treatment approach and the long-term efficacy.

Detailed description: The primary objective of this study is to looking for the gene level predictors in the patients who suffered from idiopathic membranous nephropathy. And according to the predictors, the clinicians could make a decision which method should be taken on IMN patients, Traditional Chinese Medicine or western medicine, and could get better results.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of idiopathic membranous nephropathy
* Chronic Kidney Disease (CKD)≤3 stage（Glomerular Filtration Rate (GFR)≥30ml/min）and 24 hour urinary protein≥3g
* Voluntarily participated in the study and signed an informed consent

Exclusion Criteria:

* Combined life-threatening complications such as serious infection
* Abnormal glucose metabolism
* Patients with malignant tumors or malignancy , HIV infection and a history of mental illness , acute central nervous system disease , serious gastrointestinal diseases,etc
* Pregnancy or breast-feeding women
* Undergoing other clinical trials

Primary outcomes:
measure: Genome-wide single-nucleotide-polymorphism of IMN patients treated by the Comprehensive Treatment Regimen or conventional approach
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai University of Traditional Chinese Medicine
state: Shanghai
Study officials:
affiliation: Shanghai University of Traditional Chinese Medicine
name: Wang Lin, PHD,MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05518760: COVID-19 Effectiveness Study in the Philippines
Official title: A Multicenter Study to Assess the Effectiveness of an Inactivated COVID-19 Vaccine Against Hospitalized COVID-19
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: COVID-19
Vaccine Effectiveness Against COVID-19
Hospitalized COVID-19
Keywords: COVID-19
Vaccine effectiveness
hospitalized COVID-19
inactivated COVID-19 vaccine
Lead sponsor: University of the Philippines
Sponsor class: OTHER
Collaborators: name: Coalition for Epidemic Preparedness Innovations
name: Mahidol Oxford Tropical Medicine Research Unit
name: Fudan University
First posted: 2022-08-29
Enrollment: 3000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adult patients admitted for acute respiratory illness.

Brief summary: This is a multi-site, observational, prospective test negative design case-control study which primarily aims to determine the protective effectiveness of 2 doses of an inactivated COVID-19 vaccine at least 14 days after the second dose, against hospitalized virologically-confirmed SARS-CoV-2 infection.


Eligibility criteria: Inclusion Criteria:

* Written informed consent.
* Aged 18 years of age and above
* Residing in the catchment area of the participating hospital
* Admitted to the participating hospital with an acute respiratory illness
* Able and willing to provide a naso- and oro-pharyngeal swab for RT-PCR testing

Exclusion Criteria:

* 6.2.2.1 Refusal to participate

Primary outcomes:
measure: Number of hospitalized virologically-confirmed SARS-CoV-2 infection
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Cebu City
country: Philippines
facility: Vicente Sotto Memorial Medical Center
state: Cebu Province
Study officials:
affiliation: ICHHD, University of the Philippines - National Institutes of Health
name: Jacqueline Deen, MD, MSc
role: PRINCIPAL_INVESTIGATOR
affiliation: ICHHD, University of the Philippines - National Institutes of Health
name: Michelle Ylade, MD, MSc
role: PRINCIPAL_INVESTIGATOR
affiliation: ICHHD, University of the Philippines - National Institutes of Health
name: Kristal An C Agrupis, MD, MSc
role: PRINCIPAL_INVESTIGATOR
affiliation: ICHHD, University of the Philippines - National Institutes of Health
name: Maria Vinna Crisostomo, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: ICHHD, University of the Philippines - National Institutes of Health
name: Jedas Veronica Daag, RN, RMT
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06298591: The Efficacy of Combination Therapy in Atrophic Scars
Official title: The Efficacy of Subcision in Combination With PRP Injection and Fractional Co2 Laser in Treatment of Atrophic Scar: Clinical and Ultrasonic Study
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Atrophic Scar
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2024-03-07
Enrollment: 45
Sex: ALL
Minimum age (years): 12
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: There are more than 100 million patients who develop scar formation caused by various factors, such as post-inflammatory acne and trauma (1). They often have physical, aesthetic, psychological, and social barriers. Scar tissue is naturally a stage of wound healing. Abnormal wound healing produces a spectrum of scar tissue types such as atrophic, hypertrophic, and keloid scars (2).

Atrophic scars are dermal depressions, which are commonly caused by the destruction of collagen following inflammatory process. This permanent disfiguring sequelae correlates with the duration of pathology, severity of lesion, and delay in therapy (3).

Treatment of atrophic acne scars remains a therapeutic challenge, yet there is no standard option as the most effective treatment (4). A range of possible options has been investigated including surgical techniques (subcision, non-ablative laser treatment, resurfacing techniques (ablative laser treatment, dermabrasion), and injection or dermal fillers or fat, and a combination of two or more modalities (5).

Ultrasound is a unique non-invasive and non-radiating medical imaging tool in the investigation of dermatological diseases by providing detailed anatomic and physiologic data of skin lesions and deeper soft tissue changes. Lesion size in three dimensions-lengths, width, and depth, morphology, the detailed anatomic information provided by sonography is useful to assessment of effect of different types of treatment modality to improve atrophic scar and avoid invasive assessment tools as punch biopsy for histopathological examination (6)

Detailed description: atrophic scar mangment

Eligibility criteria: Inclusion Criteria:

- Patients aged from 12 to 60 years with

* post inflammatory atrophic scar.
* post traumatic atrophic scar.
* post operative atrophic scar

Exclusion Criteria:

* post acne scar.
* active skin infection.

Primary outcomes:
measure: change of dermal thickness in sonar and Vancouver scale
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04036591: Use Of The ABSS In Infants With ARIS Treated With Outpatient Respiratory Physiotherapy
Official title: Use Of The "Acute Bronchiolitis Severity Scale" In Infants With Acute Respiratory Infection Susceptible To Outpatient Respiratory PhysiotherapyTreatment
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acute Disease Respiratory
Keywords: Clinical scale
infant
respiratory therapy
Lead sponsor: FisioRespiración
Sponsor class: OTHER
Collaborators: name: Neumomadrid
name: Universidad Complutense de Madrid
First posted: 2019-07-30
Enrollment: 32
Sex: ALL
Minimum age (years): 1
Maximum age (years): 24
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All children who attend to FisioRespiración (Private respiratory physiotherapy unit in Madrid) to receive outpatient respiratory physiotherapy treatment and meet the inclusion/exclusion criteria will be selected until reaching the sample.

Brief summary: Background. Acute respiratory infections in childhood have high incidence and morbimortality rates, generating significant sanitary and social costs. Due to its diversity of manifestations and clinical forms, the degree of severity varies widely.

Published acute respiratory infections assessment severity scales are mainly focused on acute bronchiolitis, but there is no validated scale to evaluate the effects of respiratory physiotherapy in acute respiratory infections in children.

Objective. To study the usefulness of the Acute Bronchiolitis Severity Scale to assess children under 24 months suffering from acute respiratory infections susceptible to receive outpatient respiratory physiotherapy treatment.

Methods. Pre-post assessment descriptive study using the Acute Bronchiolitis Severity Scale. Children under 24 months suffering from acute respiratory infection will be evaluated during the first outpatient respiratory physiotherapy treatment.


Eligibility criteria: Inclusion Criteria:

* Under 24 months
* ARIS diagnosed
* Medical indication of respiratory physiotherapy
* Evaluated during the first outpatient respiratory physiotherapy treatment

Exclusion Criteria:

* Chronic desease
* ABSS ≥ 7
* Temperature≥ 38ºC
* Stridor
* Expiratory groan
* Sternal sinking
* Any sign or symptom indicative of need for urgent medical evaluation

Primary outcomes:
measure: Usefulness of Acute Bronchiolitis Severity Score (ABSS) to asses children under 24 months suffering from acute respiratory infection susceptible to receive outpatient respiratory physiotherapy treatment.
timeFrame: Through study completion, an average of 2 years.
measure: Immediate effectiveness of outpatient respiratory physiotherapy treatment.
timeFrame: Measurements will be taken during the outpatient respiratory physiotherapy treatment, 1 hour approximately. Pre treatment data will be collected before starting the treatment and post data 5 minutes after finishing the last manouver.
Secondary outcomes:
Other outcomes:
Locations:
city: Madrid
country: Spain
facility: FisioRespiración
Study officials:
References:
Clinical trial NCT01969591: Fast Track Laparoscopic Surgery: A Better Option for Treating Colorectal Cancer Than Conventional Laparoscopic Surgery
Official title: Fast Track Laparoscopic Surgery: A Better Option for Treating Colorectal Cancer Than Conventional Laparoscopic Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Colorectal Cancer
Keywords: Fast track surgery, Laparoscopic surgery, colorectal cancer
Lead sponsor: The First Hospital of Jilin University
Sponsor class: OTHER
First posted: 2013-10-25
Enrollment: 70
Sex: ALL
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: To compare the outcomes of fast track laparoscopic surgery and conventional laparoscopic surgery.

Detailed description: Method: This study is a blinded randomized trial. 70 patients with colorectal cancer will undergo laparoscopic colorectal resection, and will be divided into two groups. Protocols for fast-track group includes skipping preoperative mechanical bowel preparation, early restoration of diet and early postoperative ambulation. Outcome measures, length of hospital stay, postoperative surgical stress response (C reactive protein) and postoperative complications will be compared between the two groups.

Eligibility criteria: Inclusion Criteria:

* Age ≤75 years
* Good nutrition
* no systemic infection
* Elective laparoscopic surgery

Exclusion Criteria:

* Age \>75 years
* Malnutrition or an organ system infection
* Associated with obstruction, bleeding, emergency surgery or surgical intervention
* Tumor with extensive metastasis
* Before operation patient was fasting, underwent gastrointestinal decompression and received nutritional support
* Previous history of abdominal surgery
* Patient had previously undergone gastrostomy

Primary outcomes:
measure: Length of hospital stay
timeFrame: with the first 30 days(plus or minus 3days) after surgery
measure: Postoperative days
timeFrame: with the first 30 days(plus or minus 3days) after surgery
measure: First flatus time
timeFrame: with the first 30 days(plus or minus 3days) after surgery
measure: First defecation time
timeFrame: with the first 30 days(plus or minus 3days) after surgery
measure: solid diet time
timeFrame: with the first 30 days(plus or minus 3days) after surgery
Secondary outcomes:
measure: Analgesics
timeFrame: with the first 30 days(plus or minus 3days) after surgery
measure: CRP (mg/L)
timeFrame: with the first 30 days(plus or minus 3days) after surgery
measure: Complications:anastomotic leakage,intestinal obstruction,wound infection
timeFrame: one year
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00926991: Chest Wall Repair of Rib Fractures After Trauma
Official title: Chest Wall Stabilization for Traumatic Chest Wall Injuries: An Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rib Fractures
Lead sponsor: Vanderbilt University
Sponsor class: OTHER
First posted: 2009-06-24
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Vanderbilt University Trauma Center.

Brief summary: This is a prospective, observational trial of 50 patients who have multiple, severe rib fractures following trauma. The investigators will follow their hospital stay for outcomes (infections, length of stay and medical care) as well as their early post-hospital course.

Detailed description: Hypothesis:

Rib fracture repair utilizing open reduction and internal fixation with commercially available rib plating systems improves outcomes (i.e., infectious complications), decreases hospital stay and mortality.

Study Design:

This is a prospective, observational study of 50 patients who, due to their injury pattern, are operative candidates for open reduction and internal fixation with commercial available rib plating systems for one of the following indications:

1. Flail chest with/without failure to wean from the ventilator
2. Significantly displaced rib fractures with/without lung impalement
3. Symptomatic multiple rib fractures - Failure of pain control

Outcome measures to be evaluated include:

1. Hospital Mortality
2. Ventilator free days
3. Need for tracheotomy
4. Infectious Complications (pneumonia, bacteremia, UTI, empyema)
5. Hospital \& ICU Days
6. Disposition following discharge

Eligibility criteria: Inclusion Criteria:

* Subjects must be at least \>18 years of age
* Subjects must have one of the following clinical indications:
* \>3 rib flail segments with paradoxical chest wall movement
* Non-repair of defect may result in pulmonary hernia
* Minimal associated injuries
* Severely displaced fractures are significantly impeding lung expansion.
* Failure of narcotics or epidural pain catheter to control pain

Exclusion Criteria:

* Significant pulmonary contusion
* Significant brain injury (AIS 4 and/or ICP monitoring)
* Severe associated injuries which, in the opinion of the surgeon will preclude operative chest wall stabilization
* Subjects not expected to survive the 90-day follow-up period
* Known pregnancy
* Prisoners

Primary outcomes:
measure: pain scales
timeFrame: daily
measure: ventilator requirement
timeFrame: daily
measure: hospital days
timeFrame: discharge
Secondary outcomes:
Other outcomes:
Locations:
city: Nashville
country: United States
facility: Vanderbilt University Medical Center
state: Tennessee
Study officials:
affiliation: Vanderbilt University Medical Center
name: Jose J Diaz, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06567691: Endoscopic Gastroenterostomy Versus Surgical Gastrojejunostomy
Official title: Endoscopic Gastroenterostomy Versus Surgical Gastrojejunostomy for Treatment of Malignant Gastric Outlet Obstruction: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Malignant Gastric Outlet Obstruction
Lead sponsor: Vanderbilt University Medical Center
Sponsor class: OTHER
First posted: 2024-08-23
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Recent comparative data suggest that EUS gastroenterostomy offers more durable patency than enteral stents for treatment of malignant GOO, leading some endoscopists to suggest that EUS gastroenterostomy should be the preferred endoscopic treatment approach.

EUS gastroenterostomy and surgical gastrojejunostomy have been compared in retrospective cohort analysis, suggesting a high technical success rate a shorter hospital length of stay for the endoscopic approach \[4\]. Comparison of these techniques has not been reported in controlled prospective fashion. A prospective trial is necessary in order to define the optimal interventional management option for treatment of malignant GOO in the context of the contemporary and rapidly evolved range of available endoscopic and surgical treatment options.


Eligibility criteria: Inclusion Criteria:

* Age 18 years or older
* Able to provide informed consent
* Biopsy-proven cancer
* Cancer without surgical resection as a curative treatment option
* Clinical and radiographic presentation consistent with primary or metastatic tumor causing foregut obstruction at the level of the pylorus and/or duodenum

Exclusion Criteria:

* Age \<18 years
* Pregnancy
* Unable to provide informed consent
* White Blood Count \< 3,000
* Absolute Neutrophil Count \< 1,500
* International normalized ratio \> 1.6
* Platelet count \< 100,000
* Cancer with surgical resection as a curative treatment option
* Surgically altered foregut anatomy
* Multifocal intestinal obstruction
* Abdominal ascites prohibitive of surgical candidacy
* Abdominal wall mesh prohibitive of surgical candidacy
* Child's Class B or C cirrhosis
* Gastroesophageal varices or known portal hypertension
* Body mass index \>40

Primary outcomes:
measure: Compare of restoration of oral intake following EUS versus surgical gastrojejunostomy
timeFrame: 1 day post-operative
measure: Compare post procedure length of hospital stay
timeFrame: 14 days post-operative
Secondary outcomes:
Other outcomes:
Locations:
city: Nashville
country: United States
facility: Vanderbilt University Medical Center
state: Tennessee
Study officials:
affiliation: Vanderbilt University Medical Center
name: Patrick Yachimski, MD
role: PRINCIPAL_INVESTIGATOR
References: