Clinical trial NCT03912766: Serum Copeptin as a Predictor of the Risk of Hyponatremia After Transurethral Prostatectomy
Official title: Serum Copeptin as a Predictor of the Risk of Hyponatremia After Transurethral Prostatectomy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Keywords: transurethral prostatectomy
copeptin
hyponatremia
risk prediction
Lead sponsor: Medical University of Lodz
Sponsor class: OTHER
First posted: 2019-04-11
Enrollment: 43
Sex: MALE
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: male patients with benign prostatic hyperplasia (BPH) who wre undergoing transurethral resection of the prostate (TURP)

Brief summary: Hyponatremic hypovolemia is a frequent complication of transurethral resection of the prostate gland (TURP). Copeptin has been established as is a surrogate marker of vasopressin and is measured useful for thea clinical assessment of various sodium and water disturbances. The aim of our the study was to assess the utility of serum concentration of copeptin (CPP) and brain natriuretic peptide (NT-proBNP) for the prediction of postoperative alterations of serum sodium concentration. Study population comprised 43 patients with benign prostatic hyperplasia (BPH) undergoing transurethral resection of the prostate gland. In a forward stepwise multiple regression only serum copeptin before the surgery and the duration of TURP significantly explained the variation of sodium concentration for 12 hours from the start of the surgery. Serum NT-proBNP before the surgery did not predict hyponatremia 12 hours after TURP.Conclusion Serum copeptin before TURP surgery but not NT-proBNP may be a clinically useful marker of a decrease of serum sodium after TURP surgery.

Detailed description: Introduction.Hyponatremic hypovolemia is a frequent complication of transurethral resection of the prostate gland (TURP). Copeptin has been established as is a surrogate marker of vasopressin and is measured useful for thea clinical assessment of various sodium and water disturbances. The aim of our the study was to assess the utility of serum concentration of copeptin (CPP) and brain natriuretic peptide (NT-proBNP) for the prediction of postoperative alterations of serum sodium concentration.

Methods. Study population comprised 43 patients with benign prostatic hyperplasia (BPH) undergoing transurethral resection of the prostate gland (TURP) Serum sodium and copeptin (CPP) were measured before the procedure and 12 hours after its completion. and sSerum NT-proBNP was assessment at baseline. Total amount of fluids and sodium administered intravenously and to flush the bladder during TURP was calculated in each patient. Receiver operator characteristics (ROC) curve analysis was used to determine the value of of copeptin (CPP) and NT-proBNP for that could prediction of the decrease of serum sodium after TURP

Eligibility criteria: Inclusion Criteria:

- glomerular filtration rate estimated from serum creatinine with CKD-EPI formula (eGFR) \>45 ml/min.

Exclusion Criteria:

* acute infection
* heart failure (NYHA stage 3 or 4)
* diabetes insipidus
* nephrogenic diabetes insipidus
* other sodium homeostasis abnormalities
* impaired consciousness
* psychogenic polydipsia
* alcohol abuse.

Primary outcomes:
measure: change of serum sodium after surgery
timeFrame: change of serum sodium from baseline to 12 hours post surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Łódź
country: Poland
facility: Department of Nephrology, Hypertension and Kidney Transplantation
Study officials:
affiliation: Medical University of Lodz
name: Michal Nowicki, MD PhD
role: PRINCIPAL_INVESTIGATOR
References: