Clinical trial NCT07011901: Precision Analytic Research Methods in OCD
Official title: Dissecting Neurocognitive Components of Compulsivity Using Computational Modeling and EEG
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Obsessive Compulsive Disorder
Keywords: Obsessive Compulsive Disorder
Exposure and response prevention
Cognitive Behavioral Therapy
Electroencephalogram
Lead sponsor: Icahn School of Medicine at Mount Sinai
Sponsor class: OTHER
Collaborators: name: National Institute of Mental Health (NIMH)
First posted: 2025-06-10
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Psychiatric disorders characterized by compulsivity, such as obsessive-compulsive disorder (OCD), result in considerable functional impairment and many individuals do not respond to gold-standard treatments. Compulsivity has long been thought to occur due to exaggerated habits and reduced goal-directed control, although more recently, this conceptualization of compulsivity as an imbalance of two cognitive systems has been challenged as overly narrow. This study will recruit 100 individuals (50 adults diagnosed with OCD, 50 healthy controls) and leverage the measurement precision offered by theory-driven computational modeling in combination with electroencephalogram (EEG) to go beyond this binary theory of compulsivity, revealing how more complex interactions of neurocognitive subcomponents contribute to compulsivity-information that could ultimately lead to improved treatment personalization and clinical outcomes.


Eligibility criteria: Inclusion Criteria:

Participants must be:

* between the ages 18-55 years old
* English-speaking
* right-handed
* able to provide consent

Exclusion Criteria:

Individuals diagnosed with OCD will be excluded if:

* they meet diagnostic criteria for certain other psychiatric disorders
* are taking psychiatric medication or have received behavioral treatment for OCD within a certain timeframe
* if it is unsafe for them to participate in research

Healthy control participants will be excluded if:

* they have a current psychiatric disorder
* a lifetime history of certain psychiatric disorders
* are taking psychiatric medication or have in the past
* have a parent or sibling who has been diagnosed with OCD
* if it is unsafe for them to participate in research

Primary outcomes:
measure: Yale Brown Obsessive Compulsive Scale
timeFrame: Week 1, Week 5, Week 10
Secondary outcomes:
measure: Obsessive Compulsive Inventory- Revised
timeFrame: Week 1, Week 5, Week 10
measure: Cambridge-Chicago Compulsivity Trait Scale
timeFrame: Week 1, Week 5, Week 10
measure: Self-Report Habit Index
timeFrame: Week 1, Week 5, Week 10
measure: Dimensional Obsessive- Compulsive Scale
timeFrame: Week 1, Week 5, Week 10
Other outcomes:
Locations:
city: New York
country: United States
facility: Icahn School of Medicine at Mount Sinai
state: New York
Study officials:
affiliation: Icahn School of Medicine at Mount Sinai
name: Amy Rapp, PhD
role: PRINCIPAL_INVESTIGATOR
References: