Clinical trial NCT04484662: Potted Mint Plants
Official title: Effects of Potted Mint Plants on Indoor Air Quality and the Concentration of Bacterium and Fungus, and Evaluation of Cardiovascular Health
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Cardiovascular Diseases
Keywords: Potted mint plants
Indoor air quality
Fungus
Bacteria
Cardiovascular health
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2020-07-23
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: This study will recruit 60 subjects, in sum of 30 families.
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study will recruit 60 subjects, in sum of 30 families. We will measure 2 indoor environments (living room and bedroom) for All-in-one monitoring the indoor air quality, in which collected culturable fungus and bacteria indoor to calculate colony forming unit (CFU). We will apply Kore Technology (MS-200) (Electron Ionization time-of-flight mass spectrometry, EI-TOF-MS) to measure the indoor volatile organic chemicals (VOCs) before intervention and perform repeated measurements of VOCs and the concentration of phytoncides before intervention and one week later after placing potted plants into indoor environments (living room and bedroom).

In conclusion, this study aims to investigate the clinical utility of potted mint plants in reducing indoor bacterial and fungal growth and indoor air pollution, and cardiovascular benefits. Furthermore, the possible application of indoor potted mint plant in antiviral influenza or pneumonia in the future.

Detailed description: The contribution of air pollution is a very important public health issue for human health. Indoor air quality may have more influence on human health than outdoor air pollution. Previous studies indicate indoor air pollution which causes respiratory disease has been associated with cardiovascular disease. Besides, some studies showed that indoor CO2 concentration was positively correlated with virus detection and bacterial concentration in the air, and coagulase-negative staphylococci (CNS) was detected in many poorly ventilated indoor environments. Mint can release chemical substance to inhibit viruses and bacteria. Among the components, the menthol and terpineol induced vasodilation so as to reduce blood pressure. For the pilot study we have finished the qualitative and quantitative research in chemical components released by the mint.

Therefore, this study aims to evaluate the indoor air quality and the distribution of fungal and bacterial concentration in the indoor environment, analyze the effect of potted mint plants on indoor air quality, fungal and bacterial concentration, and explore the correlation between the intervention of potted mint plants and cardiovascular health.

This study will recruit 60 subjects, in sum of 30 families. We will measure 2 indoor environments (living room and bedroom) for All-in-one monitoring the indoor air quality, in which collected culturable fungus and bacteria indoor to calculate colony forming unit (CFU). We will apply Kore Technology (MS-200) (Electron Ionization time-of-flight mass spectrometry, EI-TOF-MS) to measure the indoor volatile organic chemicals (VOCs) before intervention and perform repeated measurements of VOCs and the concentration of phytoncides before intervention and one week later after placing potted plants into indoor environments (living room and bedroom).

Furthermore, we used matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS) to identify microbiology; simultaneously, we record the outdoor environment and indoor ventilation. To assess subjects' cardiovascular health, we use DynaPulse to evaluate their cardiovascular function, and make them equipped with Holter electrocardiography (ECG) to continuously monitor the trend of heart rate variability (HRV) before and after intervention.

In conclusion, this study aims to investigate the clinical utility of potted mint plants in reducing indoor bacterial and fungal growth and indoor air pollution, and cardiovascular benefits. Furthermore, the possible application of indoor potted mint plant in antiviral influenza or pneumonia in the future.

Eligibility criteria: Inclusion Criteria:

* in the Department of Cardiology or inpatients at National Taiwan University Hospital
* aged 20-80
* live in the Greater Taipei area

Exclusion Criteria:

* The research subjects must agree to cooperate with the health assessment.
* serious brain, heart disease and mental illness
* uncomfortable reactions

Primary outcomes:
measure: Improve Indoor Air Quality
timeFrame: one week
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
state: Chung-Shan
Study officials:
affiliation: NTUH
name: Su ta chen, PI
role: PRINCIPAL_INVESTIGATOR
References: