Clinical trial NCT02239120: Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)
Official title: Randomized, Double-blind, Evaluation in Secondary Stroke Prevention Comparing the EfficaCy and Safety of the Oral Thrombin Inhibitor Dabigatran Etexilate (110 mg or 150 mg, Oral b.i.d.) Versus Acetylsalicylic Acid (100 mg Oral q.d.) in Patients With Embolic Stroke of Undetermined Source (RESPECT ESUS)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Stroke
Secondary Prevention
Lead sponsor: Boehringer Ingelheim
Sponsor class: INDUSTRY
First posted: 2014-09-12
Enrollment: 5390
Sex: ALL
Minimum age (years): 18
Maximum age (years): 150
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: This trial will enroll approximately 6,000 patients with recent embolic stroke of unknown source (ESUS). Patients will be randomized to dabigatran or acetylsalicyclic acid (ASA) (1:1 ratio) and have visits every three months. The study doctor may prescribe blinded concomitant ASA for pts with coronary artery disease but this is not mandatory. All Adverse Events (AEs), Serious Adverse Events (SAEs), outcome events will be recorded. The trial will conclude when the required number of stroke events are positively adjudicated which is estimated to take 3 years (including 2.5 years of enrollment).


Eligibility criteria: Inclusion criteria:

* Ischemic stroke with a brain lesion visualized by neuroimaging (either brain Computed Tomography (CT) or Magnetic Resonance Image (MRI)). The visualized stroke is a non-lacunar infarct , e.g. involving the cortex or \>1.5 cm (\>2.0 cm if measured on MRI diffusion-weighted images) in largest diameter if exclusively subcortical.Visualization by CT usually requires delayed imaging \>24-48 hours after stroke onset.
* The index stroke must have occurred either up to 3 months before randomization (Modified Rankin Scale(mRS) \<=3 at randomization) or up to 6 months before randomization (mRS \<=3 at randomization) in selected patients that are \>= 60 years plus at least one additional risk factor for recurrent stroke.
* Arterial imaging or cervical plus Transcranial Doppler (TCD) ultrasonography does not show extra-cranial or intracranial atherosclerosis with \>= 50% luminal stenosis in artery supplying the area of acute ischemia.
* As evidenced by cardiac monitoring for \>= 20 hours with automated rhythm detection, there is absence of AF \> 6 minutes in duration (within a 20 hour period, either as single episode or cumulative time of multiple episodes).

Further inclusion criteria apply.

Exclusion criteria:

* Modified Rankin Scale of \>=4 at time of randomization or inability to swallow medications.
* Major risk cardioembolic source of embolism such as: a) intracardiac thrombus as evidenced by transthoracic or transesophageal echocardiography, b) paroxysmal, persistent or permanent Atrial fibrillation (AF), c) atrial flutter, d) prosthetic cardiac valve (mitral or aortic, bioprosthetic or mechanical), e) atrial myxoma, f) other cardiac tumors, g) moderate or severe mitral stenosis, h) recent (\< 4weeks) myocardial infarction, i) valvular vegetations, or j) infective endocarditis.
* Any indication that requires treatment with an anticoagulant as per Investigator's judgment.
* History of atrial fibrillation (unless it was due to reversible causes such as hyperthyroidism or binge drinking, and has been permanently resolved).
* Other specific stroke etiology (i.e. cerebral arteritis or arterial dissection, migraine with aura/vasospasm, drug abuse).
* Renal impairment with estimated creatinine clearance (as calculated by Cockcroft-Gault equation) \<30mL/min at screening, or where Investigator expects creatinine clearance is likely to drop below 30mL/min during the course of the study.

Further exclusion criteria apply.

Primary outcomes:
measure: Adjudicated Recurrent Stroke
timeFrame: From randomisation until full follow up period, approximately 43 months.
measure: First Major Bleed (Adjudicated)
timeFrame: Between the first trial medication intake up to 6 days after the last trial medication intake, approximately 42 months.
Secondary outcomes:
measure: Adjudicated Ischaemic Stroke
timeFrame: From randomisation until full follow up period, up to 43 months
measure: Adjudicated Composite of Non-fatal Stroke, Non-fatal Myocardial Infarction, or Cardiovascular Death
timeFrame: From randomisation until full follow up period, up to 43 months
measure: Disabling Stroke
timeFrame: From randomisation until full follow up period, up to 43 months
measure: All-cause Death
timeFrame: From randomisation until full follow up period, up to 43 months
measure: Adjudicated Intracranial Hemorrhage
timeFrame: Between the first trial medication intake up to 6 days after the last trial medication intake, approximately 42 months.
measure: Adjudicated Fatal Bleed
timeFrame: Between the first trial medication intake up to 6 days after the last trial medication intake, approximately 42 months.
measure: Adjudicated Life-threatening Bleed
timeFrame: Between the first trial medication intake up to 6 days after the last trial medication intake, approximately 42 months.
measure: Any Bleed (Investigator-reported)
timeFrame: Between the first trial medication intake up to 6 days after the last trial medication intake, approximately 42 months.
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Bronislava Shafran, MD PC
state: Arizona
city: Beverly Hills
country: United States
facility: Westside Medical Associates of Los Angeles
state: California
city: El Cajon
country: United States
facility: TriWest Research Associates, LLC
state: California
city: Fresno
country: United States
facility: University of California
state: California
city: Glendale
country: United States
facility: Glendale Adventist Medical Center
state: California
city: Long Beach
country: United States
facility: Collaborative Neuroscience Network, LLC (CNS)
state: California
city: Los Angeles
country: United States
facility: Kaiser Permanente Los Angeles Medical Center
state: California
city: Los Angeles
country: United States
facility: University of California Los Angeles
state: California
city: Pasadena
country: United States
facility: Huntington Hospital
state: California
city: San Diego
country: United States
facility: University of California
state: California
city: San Francisco
country: United States
facility: University of California
state: California
city: Aurora
country: United States
facility: University of Colorado Denver
state: Colorado
city: Englewood
country: United States
facility: Colorado Neurological Institute
state: Colorado
city: Fort Collins
country: United States
facility: University of Colorado Denver
state: Colorado
city: Grand Junction
country: United States
facility: St. Mary's Hospital and Regional Medical Center
state: Colorado
city: Hartford
country: United States
facility: Hartford Hospital
state: Connecticut
city: Atlantis
country: United States
facility: JEM Research Institute
state: Florida
city: Boca Raton
country: United States
facility: Boca Raton Regional Hospital
state: Florida
city: Boynton Beach
country: United States
facility: Tenet Florida Physician Services
state: Florida
city: Bradenton
country: United States
facility: Nova Clinical Research, LLC
state: Florida
city: Deerfield Beach
country: United States
facility: Broward Health North
state: Florida
city: Hialeah
country: United States
facility: Center for Advanced Research Excellence
state: Florida
city: Miami
country: United States
facility: Bruce W. Carter, Miami VA Healthcare System
state: Florida
city: Miami
country: United States
facility: University of Miami
state: Florida
city: Panama City
country: United States
facility: Bay Neurological Institute
state: Florida
city: Saint Petersburg
country: United States
facility: Carol L Pappas, MD PhD PA
state: Florida
city: Tampa
country: United States
facility: University of South Florida
state: Florida
city: Vero Beach
country: United States
facility: Vero Beach Neurology and Research Institute
state: Florida
city: West Palm Beach
country: United States
facility: Palm Beach Neuroscience Institute
state: Florida
city: Augusta
country: United States
facility: Augusta University
state: Georgia
city: Marietta
country: United States
facility: WellStar Medical Group - Neurosurgery
state: Georgia
city: Honolulu
country: United States
facility: The Queen's Medical Center
state: Hawaii
city: Boise
country: United States
facility: Saint Alphonsus Medical Center-Neurology
state: Idaho
city: Arlington Heights
country: United States
facility: Northwest Heart Clinical Research, LLC
state: Illinois
city: Chicago
country: United States
facility: Northwestern University
state: Illinois
city: Chicago
country: United States
facility: Rush University Medical Center
state: Illinois
city: Chicago
country: United States
facility: University of Chicago
state: Illinois
city: Fairview Heights
country: United States
facility: Medicoricium, LLC
state: Illinois
city: Peoria
country: United States
facility: OSF Saint Francis Medical Center
state: Illinois
city: Quincy
country: United States
facility: Quincy Physicians and Surgeons Clinic, S.C.
state: Illinois
city: Springfield
country: United States
facility: Southern Illinois University School of Medicine
state: Illinois
city: Anderson
country: United States
facility: Community Clinical Research Center
state: Indiana
city: Des Moines
country: United States
facility: Ruan Neurology Clinic and Research Center
state: Iowa
city: Lexington
country: United States
facility: Associates in Neurology, PSC
state: Kentucky
city: Louisville
country: United States
facility: University of Louisville
state: Kentucky
city: Alexandria
country: United States
facility: Alexandria Cardiology Clinic
state: Louisiana
city: Marrero
country: United States
facility: Culicchia Neurological Clinic
state: Louisiana
city: New Orleans
country: United States
facility: Tulane University Hospital and Clinic
state: Louisiana
city: New Orleans
country: United States
facility: Ochsner Medical Center
state: Louisiana
city: Annapolis
country: United States
facility: Anne Arundel Medical Center
state: Maryland
city: Baltimore
country: United States
facility: Johns Hopkins Hospital
state: Maryland
city: Boston
country: United States
facility: Massachusetts General Hospital
state: Massachusetts
city: Boston
country: United States
facility: Beth Israel Deaconess Medical Center
state: Massachusetts
city: Newton
country: United States
facility: Newton-Wellesley Hospital
state: Massachusetts
city: Detroit
country: United States
facility: Henry Ford Health System
state: Michigan
city: Flint
country: United States
facility: McLaren Flint
state: Michigan
city: Grand Rapids
country: United States
facility: Mercy Health Saint Mary's
state: Michigan
city: Grand Rapids
country: United States
facility: Spectrum Health Medical Center
state: Michigan
city: Lansing
country: United States
facility: Sparrow Clinical Research Institute
state: Michigan
city: Pontiac
country: United States
facility: St. Joseph Mercy Oakland
state: Michigan
city: Duluth
country: United States
facility: The Duluth Clinic dba Essentia Health Duluth Clinic
state: Minnesota
city: Minneapolis
country: United States
facility: Abbott Northwestern Hospital, Radiology Department
state: Minnesota
city: Saint Paul
country: United States
facility: HealthPartners Neuroscience Center
state: Minnesota
city: Jackson
country: United States
facility: Jackson Heart Clinic, P.A.
state: Mississippi
city: Columbia
country: United States
facility: Boone Hospital Center
state: Missouri
city: Columbia
country: United States
facility: University of Missouri Health System
state: Missouri
city: Fenton
country: United States
facility: SSM Health St. Clare Hospital
state: Missouri
city: Kansas City
country: United States
facility: Saint Luke's Hospital of Kansas City
state: Missouri
city: Saint Louis
country: United States
facility: Saint Louis University
state: Missouri
city: Saint Louis
country: United States
facility: St. Louis Heart and Vascular, P.C.
state: Missouri
city: Omaha
country: United States
facility: The Nebraska Medical Center
state: Nebraska
city: Reno
country: United States
facility: Renown Institute for Neurosciences
state: Nevada
city: Brooklyn
country: United States
facility: NYC Health + Hospitals/Coney Island
state: New York
city: Cortlandt Manor
country: United States
facility: New York Presbyterian Hudson Valley Hospital
state: New York
city: Johnson City
country: United States
facility: UHS Wilson Medical Center,Office of Clin Trials
state: New York
city: Manhasset
country: United States
facility: North Shore University Hospital
state: New York
city: Mineola
country: United States
facility: Winthrop University Hospital
state: New York
city: New York
country: United States
facility: Mount Sinai Beth Israel
state: New York
city: Charlotte
country: United States
facility: Novant Health Neurology Specialists
state: North Carolina
city: Durham
country: United States
facility: Duke Clinic 1L
state: North Carolina
city: Greensboro
country: United States
facility: Cone Health System
state: North Carolina
city: Hickory
country: United States
facility: Novant Health Neurology Hickory
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest University Health Sciences
state: North Carolina
city: Grand Forks
country: United States
facility: Altru Health System
state: North Dakota
city: Columbus
country: United States
facility: The Ohio State University Wexner Medical Center
state: Ohio
city: Gallipolis
country: United States
facility: Holzer Clinic LLC
state: Ohio
city: Youngstown
country: United States
facility: Advanced Neurology Associates
state: Ohio
city: Portland
country: United States
facility: Oregon Health and Sciences University
state: Oregon
city: Portland
country: United States
facility: Veterans Affairs Portland Health Care System
state: Oregon
city: Springfield
country: United States
facility: Sacred Heart Medical Center at RiverBend
state: Oregon
city: Hershey
country: United States
facility: Penn State Milton S. Hershey Medical Center
state: Pennsylvania
city: Philadelphia
country: United States
facility: Thomas Jefferson University
state: Pennsylvania
city: Philadelphia
country: United States
facility: Temple University Hospital
state: Pennsylvania
city: Willow Grove
country: United States
facility: Abington Neurological Associates
state: Pennsylvania
city: Providence
country: United States
facility: Rhode Island Hospital
state: Rhode Island
city: Greenville
country: United States
facility: Greenville Memorial Hospital
state: South Carolina
city: Memphis
country: United States
facility: Methodist University Hospital
state: Tennessee
city: Nashville
country: United States
facility: Centennial Heart Cardiovascular Consultants, LLC
state: Tennessee
city: Nashville
country: United States
facility: Saint Thomas Health
state: Tennessee
city: Austin
country: United States
facility: Seton Medical Center Austin
state: Texas
city: Houston
country: United States
facility: Houston Methodist Hospital
state: Texas
city: Lubbock
country: United States
facility: Bhupesh Dihenia, M.D.,P.A.
state: Texas
city: Burlington
country: United States
facility: University of Vermont
state: Vermont
city: Richmond
country: United States
facility: Virginia Commonwealth University
state: Virginia
city: Roanoke
country: United States
facility: Carilion Riverside
state: Virginia
city: Seattle
country: United States
facility: Virginia Mason Medical Center
state: Washington
city: Seattle
country: United States
facility: Swedish Neuroscience Institute
state: Washington
city: Huntington
country: United States
facility: Marshall University
state: West Virginia
city: Green Bay
country: United States
facility: Aurora BayCare Medical Center
state: Wisconsin
city: Madison
country: United States
facility: University of Wisconsin
state: Wisconsin
city: Caba
country: Argentina
facility: STAT Research
city: Caba
country: Argentina
facility: Fundación Favaloro
city: Caba
country: Argentina
facility: Hospital Italiano de Buenos Aires
city: Cordoba
country: Argentina
facility: Instituto Médico DAMIC S.R.L.
city: Coronel Suarez
country: Argentina
facility: Clinica Coronel Suarez SA
city: Mar del Plata
country: Argentina
facility: Hospital Privado de Comunidad
city: Camperdown
country: Australia
facility: Royal Prince Alfred Hospital
state: New South Wales
city: Darlinghurst
country: Australia
facility: St Vincent's Hospital Sydney
state: New South Wales
city: Kanwal
country: Australia
facility: Kanwal Medical Complex
state: New South Wales
city: New Lambton
country: Australia
facility: John Hunter Hospital
state: New South Wales
city: St Leonards
country: Australia
facility: Royal North Shore Hospital
state: New South Wales
city: Birtinya
country: Australia
facility: Sunshine Coast University Hospital
state: Queensland
city: Herston
country: Australia
facility: Royal Brisbane and Women's Hospital
state: Queensland
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital
state: South Australia
city: Adelaide
country: Australia
facility: Calvary North Adelaide Hospital
state: South Australia
city: Box Hill
country: Australia
facility: Box Hill Hospital
state: Victoria
city: Heidelberg
country: Australia
facility: Austin Health
state: Victoria
city: Parkville
country: Australia
facility: Royal Melbourne Hospital
state: Victoria
city: Victoria
country: Australia
facility: Alfred Health
city: Graz
country: Austria
facility: LKH-Univ. Hospital Graz
city: Innsbruck
country: Austria
facility: Medical University of Innsbruck
city: Linz
country: Austria
facility: Kepler Univ. Klinikum Linz
city: Linz
country: Austria
facility: Kepler Univ. Klinikum Linz
city: Linz
country: Austria
facility: KH d. Barmherzigen Brüder Linz, Neurologie
city: Tulln
country: Austria
facility: Universitätsklinikum Tulln, Abteilung für Neurologie
city: Vienna
country: Austria
facility: Hosp.Hietzing with Neuro.Centr Rosenhuegel,II Neuro.dep,Wien
city: Wien
country: Austria
facility: Wilhelminenspital
city: Aalst
country: Belgium
facility: Aalst - HOSP Onze-Lieve-Vrouw
city: Arlon
country: Belgium
facility: Arlon - HOSP Sud Luxembourg - Vivalia
city: Brugge
country: Belgium
facility: AZ Sint-Jan Brugge
city: Brussel
country: Belgium
facility: Brussels-UNIV Brugmann -Horta
city: Brussel
country: Belgium
facility: Brussels - HOSP Europe (Ste-Elisabeth)
city: Bruxelles
country: Belgium
facility: Brussels - UNIV Saint-Luc
city: Gent
country: Belgium
facility: UNIV UZ Gent
city: Kortrijk
country: Belgium
facility: Kortrijk - HOSP AZ Groeninge Kennedylaan
city: Leuven
country: Belgium
facility: UZ Leuven
city: Liège
country: Belgium
facility: Liège - HOSP St-Joseph
city: Roeselare
country: Belgium
facility: Roeselare - HOSP AZ Delta
city: Rumst
country: Belgium
facility: Rumst - HOSP AZ Heilige Familie
city: Sint-Truiden
country: Belgium
facility: Sint-Truiden - HOSP St-Trudo (St-Jozef)
city: Wilrijk
country: Belgium
facility: Wilrijk - HOSP GZA (St-Augustinus)
city: Yvoir
country: Belgium
facility: Yvoir - UNIV UCL de Mont-Godinne
city: Botucatu
country: Brazil
facility: Hospital Clinicas de Botucatu
city: Curitiba
country: Brazil
facility: Instituto de Medicina Flumignano
city: Joinvile
country: Brazil
facility: Clinica Neurologica e Neurocirurgica de Joinvile
city: Porto Alegre
country: Brazil
facility: Hospital de Clínicas de Porto Alegre
city: Ribeirao Preto
country: Brazil
facility: H.C.da Fac. de Medicina de Ribeirao Preto
city: Rio de Janeiro
country: Brazil
facility: Hospital Quinta D¿Or
city: Calgary
country: Canada
facility: Foothills Medical Centre
state: Alberta
city: Edmonton
country: Canada
facility: University of Alberta Hospital (University of Alberta)
state: Alberta
city: Edmonton
country: Canada
facility: Grey Nuns Hospital
state: Alberta
city: Brandon
country: Canada
facility: Prairie Mountain Health
state: Manitoba
city: Montreal
country: Canada
facility: Hopital Notre-Dame du CHUM
state: Migration Data
city: Montreal
country: Canada
facility: Jewish General Hospital
state: Migration Data
city: Saint John
country: Canada
facility: Saint John Regional Hospital
state: New Brunswick
city: St. John's
country: Canada
facility: Eastern Health (MUN)
state: Newfoundland and Labrador
city: London
country: Canada
facility: Victoria Hospital (LHSC)
state: Ontario
city: Toronto
country: Canada
facility: St. Michael's Hospital
state: Ontario
city: Toronto
country: Canada
facility: Toronto Western Hospital
state: Ontario
city: Chicoutimi
country: Canada
facility: CSSS de Chicoutimi
state: Quebec
city: Greenfield Park
country: Canada
facility: Hopital Charles - LeMoyne
state: Quebec
city: Montreal
country: Canada
facility: Montreal General Hospital - McGill University Health Centre
state: Quebec
city: Sherbrooke
country: Canada
facility: CHUS Fleurimont
state: Quebec
city: St-Jerome
country: Canada
facility: St Jerome Medical Research Inc.
state: Quebec
city: Quebec
country: Canada
facility: CHU de Quebec-Universite Laval Research Centre
city: Santiago
country: Chile
facility: Clínica Alemana de Santiago S.A.
city: Santiago
country: Chile
facility: Clínica Dávila
city: Temuco
country: Chile
facility: Clinica Alemana de Temuco
city: Beijing
country: China
facility: Beijing Tiantan Hospital affiliated to Cap Med University
city: Beijing
country: China
facility: Peking University Third Hospital
city: Changchun
country: China
facility: First Hospital of Jilin University
city: Guangzhou
country: China
facility: First Affiliated Hospital of Guangzhou Medical University
city: Guangzhou
country: China
facility: First Affiliated Hospital of Guangzhou University of TCM
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Jinan University
city: Guiyang
country: China
facility: The Affiliated Hospital of Guizhou Medical University
city: Hangzhou
country: China
facility: 2nd Affiliated Hosp Zhejiang University College of Medical
city: Hangzhou
country: China
facility: Zhejiang Hospital
city: Hangzhou
country: China
facility: The Affiliated Hospital of Hangzhou Normal University
city: Hangzhou
country: China
facility: Zhejiang University School of Medicine SIR RUN RUN SHAW Hospital
city: Jilin
country: China
facility: Jinlin Central Hospital
city: Nanchang
country: China
facility: The Second Affiliated Hospital to Nanchang University
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital
city: Nanjing
country: China
facility: Zhongda Hospital Southeast University
city: Qingdao
country: China
facility: QingDao Municipal Hospital
city: Qingdao
country: China
facility: The affiliated hospital of medicalcollege qingdao university
city: Shanghai
country: China
facility: Huashan Hospital, Fudan University
city: Shanghai
country: China
facility: Tongji Hospital, Tongji University
city: Shenyang
country: China
facility: General Hospital of Shenyang Military Region
city: Xiamen
country: China
facility: First Affiliated Hospital of Xiamen University
city: Xuzhou
country: China
facility: Affiliated Hospital, Xuzhou Medical college
city: Bogotá
country: Colombia
facility: Servicios Médicos Muñoz Solano
city: Bogotá
country: Colombia
facility: Sociedad de Cirugia de Bogota Hospital de San José
city: Cali
country: Colombia
facility: Fundación Valle del Lili
city: Floridablanca
country: Colombia
facility: Fundación Cardiovascular de Colombia
city: Varazdin
country: Croatia
facility: General Hospital Varazdin
city: Zagreb
country: Croatia
facility: Clin.Hosp.Centre Zagreb,Cerebrovascul.disease w/ intens.care
city: Zagreb
country: Croatia
facility: University hospital center Zagreb
city: Zagreb
country: Croatia
facility: Univ. Hosp. Sisters of Mercy, Neurology Clinic, Zagreb
city: Brno
country: Czechia
facility: Cerebrovascular site, private prac., Brno
city: Jihlava
country: Czechia
facility: Hospital Jihlava
city: Olomouc
country: Czechia
facility: University Hospital Olomouc
city: Ostrava
country: Czechia
facility: Cerebrovascular site, Ostrava
city: Ostrava
country: Czechia
facility: Cerebrovascular site, Ostrava
city: Prague 5
country: Czechia
facility: Hospital Homolka, Prague
city: Praha 5
country: Czechia
facility: University Hospital Motol
city: Ahtme
country: Estonia
facility: East Estonia Central Hospital, Neurology Dept, Ahtme
city: Tallinn
country: Estonia
facility: West Tallinn Central Hospital, Neurology Dept.
city: Tallinn
country: Estonia
facility: North Estonia Medical Centre Foundation, Tallin
city: Tartu
country: Estonia
facility: Tartu University Hospital
city: Aix en Provence
country: France
facility: HOP Pays d'Aix
city: Bayonne
country: France
facility: HOP de Bayonne
city: Besançon
country: France
facility: HOP Jean Minjoz
city: Bordeaux
country: France
facility: HOP Pellegrin
city: Brest
country: France
facility: HOP de la Cavale Blanche
city: Bron
country: France
facility: HOP Pierre Wertheimer
city: Caen
country: France
facility: HOP Côte de Nacre
city: Grenoble
country: France
facility: HOP Grenoble, Neuro, Grenoble
city: Lille
country: France
facility: HOP Roger Salengro
city: Metz
country: France
facility: HOP Mercy
city: Paris
country: France
facility: HOP Paris Saint-Joseph
city: Paris
country: France
facility: GHU Paris Psychiatrie et Neurosciences
city: Toulouse
country: France
facility: HOP Purpan
city: Altenburg
country: Germany
facility: Klinikum Altenburger Land GmbH
city: Bad Neustadt
country: Germany
facility: Neurologische Klinik GmbH, Bad Neustadt
city: Berlin
country: Germany
facility: Vivantes Netzwerk für Gesundheit GmbH
city: Bielefeld
country: Germany
facility: Evangelisches Klinikum Bethel gGmbH
city: Bochum
country: Germany
facility: Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil gGmbH
city: Bochum
country: Germany
facility: St. Josef- und St. Elisabeth-Hospital gGmbH
city: Bremen
country: Germany
facility: Gesundheit Nord gGmbH | Klinikverbund Bremen
city: Bremen
country: Germany
facility: Klinikum Bremerhaven
city: Buchholz
country: Germany
facility: Krankenhäuser Buchholz und Winsen gGmbH
city: Celle
country: Germany
facility: Allgemeines Krankenhaus, Celle
city: Chemnitz
country: Germany
facility: Klinikum Chemnitz gGmbH
city: Coburg
country: Germany
facility: Klinikum Coburg gGmbH
city: Dortmund
country: Germany
facility: Klinikzentrum Mitte, Dortmund
city: Dresden
country: Germany
facility: Städtisches Klinikum Dresden
city: Dresden
country: Germany
facility: Universitätsklinikum Carl Gustav Carus Dresden
city: Düsseldorf
country: Germany
facility: Universitätsklinikum Düsseldorf
city: Düsseldorf
country: Germany
facility: Marien-Hospital, Düsseldorf
city: Erlangen
country: Germany
facility: Universitätsklinikum Erlangen
city: Essen
country: Germany
facility: Alfried Krupp Krankenhaus Essen
city: Essen
country: Germany
facility: Universitätsklinikum Essen AöR
city: Frankfurt am Main
country: Germany
facility: Universitätsklinikum Frankfurt
city: Frankfurt
country: Germany
facility: Klinikum Frankfurt Höchst GmbH
city: Friedrichshafen
country: Germany
facility: Klinikum Friedrichshafen
city: Fulda
country: Germany
facility: Klinikum Fulda gAG
city: Gelsenkirchen
country: Germany
facility: Evangelische Klinik Gelsenkirchen
city: Gera
country: Germany
facility: SRH Wald-Klinikum Gera GmbH
city: Gießen
country: Germany
facility: Universitätsklinikum Gießen und Marburg GmbH
city: Greifswald
country: Germany
facility: Universitätsmedizin Greifswald
city: Günzburg
country: Germany
facility: Bezirkskrankenhaus, Günzburg
city: Hamburg
country: Germany
facility: Asklepios Klinik St. Georg
city: Hamburg
country: Germany
facility: Universitätsklinikum Hamburg-Eppendorf
city: Hamburg
country: Germany
facility: Asklepios Klinik Harburg
city: Hamburg
country: Germany
facility: Asklepios Klinik Wandsbek
city: Hamburg
country: Germany
facility: Asklepios Klinik Barmbek
city: Hamburg
country: Germany
facility: Asklepios Klinik Altona
city: Hanau
country: Germany
facility: Klinikum Hanau GmbH
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover
city: Heidelberg
country: Germany
facility: Universitätsklinikum Heidelberg
city: Heilbronn
country: Germany
facility: SLK-Kliniken Heilbronn GmbH
city: Idar-Oberstein
country: Germany
facility: Klinikum Idar-Oberstein
city: Jena
country: Germany
facility: Universitätsklinikum Jena
city: Kiel
country: Germany
facility: Universitätsklinikum Schleswig-Holstein, Campus Kiel
city: Köln
country: Germany
facility: Universitätsklinikum Köln (AöR)
city: Leipzig
country: Germany
facility: Universitätsklinikum Leipzig
city: Ludwigshafen
country: Germany
facility: Klinikum der Stadt Ludwigshafen am Rhein gGmbH
city: Magdeburg
country: Germany
facility: Universitätsklinikum Magdeburg AöR
city: Mainz
country: Germany
facility: Universitätsmedizin der Johannes Gutenberg-Universität Mainz
city: Marburg
country: Germany
facility: Universitätsklinikum Gießen und Marburg GmbH
city: Meißen
country: Germany
facility: Elblandklinikum Meißen
city: Minden
country: Germany
facility: Johannes Wesling Klinikum
city: Moenchengladbach
country: Germany
facility: Kliniken Maria Hilf GmbH
city: Mühlhausen
country: Germany
facility: Ökumenisches Hainich Klinikum gGmbH
city: München
country: Germany
facility: Klinikum der Universität München - Campus Großhadern
city: München
country: Germany
facility: Klinikum rechts der Isar der Technischen Universität München
city: Münster
country: Germany
facility: Universitätsklinikum Münster
city: Nürnberg
country: Germany
facility: Klinikum Nürnberg
city: Offenbach
country: Germany
facility: Sana Klinikum Offenbach GmbH
city: Osnabrück
country: Germany
facility: Klinikum Osnabrück GmbH
city: Regensburg
country: Germany
facility: Universitätsklinikum Regensburg
city: Sande
country: Germany
facility: Nordwest-Krankenhaus Sanderbusch gGmbH
city: Siegen
country: Germany
facility: Kreisklinikum Siegen GmbH
city: Stuttgart
country: Germany
facility: Bürgerhospital, Stuttgart
city: Teupitz
country: Germany
facility: Nervenklinik Teupitz, Teupitz
city: Trier
country: Germany
facility: Krankenhaus der Barmherzigen Brüder Trier
city: Tübingen
country: Germany
facility: Universitätsklinikum Tübingen
city: Ulm
country: Germany
facility: RKU - Universitäts- und Rehabilitationskliniken Ulm gGmbH
city: Weimar
country: Germany
facility: Sophien- und Hufeland-Klinikum gGmbH
city: Wiesbaden
country: Germany
facility: Helios Dr. Horst Schmidt Kliniken Wiesbaden
city: Würzburg
country: Germany
facility: Universitätsklinikum Würzburg
city: Alexandroupolis
country: Greece
facility: Univ.Hosp. of Alexandroupolis
city: Athens
country: Greece
facility: Gen.Hosp.of Ath.Evangelismos
city: Athens
country: Greece
facility: Attikon University Hospital
city: Herakleion
country: Greece
facility: Gen.Univ. Hosp. of Herakleion
city: Larissa
country: Greece
facility: General University Hospital of Larissa
city: Patras
country: Greece
facility: Univ. Gen. Hosp. of Patras
city: Thessaloniki
country: Greece
facility: Univ.Gen.Hosp. of Thessaloniki
city: Hong Kong
country: Hong Kong
facility: Prince of Wales Hospital
city: Hong Kong
country: Hong Kong
facility: Pamela Youde Nethersole Eastern Hospital
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital
city: Budapest
country: Hungary
facility: Semmelweis University
city: Budapest
country: Hungary
facility: National Instit.of Neurosciences,Neurology Dept,Budapest
city: Debrecen
country: Hungary
facility: Univ. Debrecen Medical Health Science Center, Neurology Dept
city: Kistarcsa
country: Hungary
facility: Pest Megyei Flor Ferenc Hospital
city: Miskolc
country: Hungary
facility: CRU Hungary Ltd, Private Practice, Miskolc
city: Pecs
country: Hungary
facility: Univ. of Pecs Clinic for Neurology
city: Bangalore
country: India
facility: St. Johns medical College and Hospital
city: Chandigarh
country: India
facility: Post Graduate Institute of Medical Education and Research
city: Guntur
country: India
facility: Lalitha Super Specialities Hospital
city: Hyderabad
country: India
facility: Nizam's Institute of Medical Sciences
city: Karamsad
country: India
facility: Shree Krishna Hospital and Research Centre
city: Kottayam
country: India
facility: Caritas Hospital
city: Mangalore
country: India
facility: Mangala Hospital and Mangala Kidney Foundation
city: Mumbai
country: India
facility: LTMMC & GH Medical College,
city: Nashik
country: India
facility: Magnum Heart Institute
city: New Delhi
country: India
facility: All India Institute of Medical Sciences
city: Pune
country: India
facility: Sahyadri Speciality Hospital
city: Hadera
country: Israel
facility: Hillel Yaffe Medical Center, Hadera
city: Holon
country: Israel
facility: Wolfson Medical Center
city: Tel Hashomer, Ramat Gan
country: Israel
facility: The Chaim Sheba Medical Center Tel Hashomer
city: Telaviv
country: Israel
facility: Sourasky Medical Center
city: Avezzano
country: Italy
facility: Osp. SS Filippo Nicola
city: Bologna
country: Italy
facility: Policlinico S. Orsola Malpighi
city: Brescia
country: Italy
facility: A.O. Spedali Civili di Brescia
city: Cona (FE)
country: Italy
facility: Azienda Ospedaliero Universitaria di Ferrara
city: Genova
country: Italy
facility: Policlinico San Martino
city: Messina
country: Italy
facility: A.O.U.Policlinico G.Martino
city: Milano
country: Italy
facility: Fondazione Centro San Raffaele del Monte Tabor
city: Milano
country: Italy
facility: Istituto Auxologico Italiano
city: Modena
country: Italy
facility: Nuovo Ospedale Civile S. Agostino-Estense
city: Padova
country: Italy
facility: Azienda Ospedaliera Universitaria di Padova
city: Perugia
country: Italy
facility: Ospedale S.Maria della Misericordia, AO di Perugia
city: Piacenza
country: Italy
facility: Osp. Guglielmo da Saliceto AUSL di Piacenza
city: Pietra Ligure
country: Italy
facility: Ospedale Santa Corona Azienda Sanitaria Locale n.2 Savonese
city: Roma
country: Italy
facility: Università degli Studi Campus Bio-Medico
city: Roma
country: Italy
facility: A.O. San Camillo Forlanini
city: Roma
country: Italy
facility: Umberto I Pol. di Roma-Università di Roma La Sapienza
city: Roma
country: Italy
facility: Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
city: Siena
country: Italy
facility: A.O.U. Senese Policlinico Santa Maria alle Scotte
city: Torino
country: Italy
facility: Ospedale Molinette, AO Città della Salute e della
city: Torino
country: Italy
facility: Ospedale Maria Vittoria
city: Treviso
country: Italy
facility: Ospedale S. Maria di Ca' Foncello Azienda ULSS9 TREVISO
city: Varese
country: Italy
facility: A. O. Ospedale Circolo Fond. Macchi
city: Verona
country: Italy
facility: Ospedale Policlinico G.B. Rossi (Borgo Roma) di Verona
city: Aichi, Nagoya
country: Japan
facility: Chubu Rosai Hospital
city: Aichi, Toyohashi
country: Japan
facility: National Hospital Organization Toyohashi Medical Center
city: Aichi, Toyota
country: Japan
facility: Toyota Memorial Hospital
city: Akita, Akita
country: Japan
facility: Reserch Institute for Brain and Blood Vessels Akita
city: Chiba, Urayasu
country: Japan
facility: Juntendo University Urayasu Hospital
city: Fukuoka, Chikushi-gun
country: Japan
facility: Go Neurosurgical Clinic
city: Fukuoka, Chikushino
country: Japan
facility: Fukuoka University Chikushi Hospital
city: Fukuoka, Fukuoka
country: Japan
facility: National Hospital Organization Kyushu Medical Center
city: Fukuoka, Fukuoka
country: Japan
facility: Fukuoka Wajiro Hospital
city: Fukuoka, Fukuoka
country: Japan
facility: Fukuoka University Hospital
city: Fukuoka, Kasuga
country: Japan
facility: Fukuoka Tokushukai Medical Center
city: Fukuoka, Kitakyushu
country: Japan
facility: Steel Memorial Yawata Hospital
city: Fukuoka, Kitakyushu
country: Japan
facility: Japan Community Health Care Organization Kyushu Hospital
city: Fukuoka, Kurume
country: Japan
facility: St. Mary's Hospital
city: Fukuoka, Kurume
country: Japan
facility: Shin Koga Hospital
city: Fukuoka, Onga
country: Japan
facility: Fukuoka Shin Mizumaki Hospital
city: Fukuoka, Tagawa
country: Japan
facility: Social Insurance Tagawa Hospital
city: Fukuoka, Yukuhashi
country: Japan
facility: Shin Yukuhashi Hospital
city: Fukushima, Date-Gun
country: Japan
facility: Fujita General Hospital
city: Fukushima, Nihonmatsu
country: Japan
facility: Shinseikai Masu Memorial Hospital
city: Gifu, Gifu
country: Japan
facility: Asahi University Hospital
city: Gifu, Takayama
country: Japan
facility: Japanese Red Cross Takayama Hospital
city: Gunma, Isesaki
country: Japan
facility: Mihara Memorial Hospital
city: Gunma, Maebashi
country: Japan
facility: Maebashi Red Cross Hospital
city: Hiroshima, Hiroshima
country: Japan
facility: Medical corporation Suiseikai Suiseikai Kajikawa Hospital
city: Hiroshima, Hiroshima
country: Japan
facility: Araki Neurosurgical Hospital
city: Hiroshima, Hiroshima
country: Japan
facility: Hiroshima Prefectural Hospital
city: Hokkaido, Sapporo
country: Japan
facility: Sapporo Shiroishi Memorial Hospital
city: Hokkaido, Sapporo
country: Japan
facility: Nakamura Memorial Hospital
city: Hyogo, Kobe
country: Japan
facility: Kobe City Medical Center General Hospital
city: Ibaraki, Toride
country: Japan
facility: JA Toride Medical Center
city: Ibaraki, Tsukuba
country: Japan
facility: Tsukuba Medical Center Hospital
city: Iwate, Morioka
country: Japan
facility: Iwate Medical University Hospital
city: Kagoshima, Kagoshima
country: Japan
facility: Kagoshima City Hospital
city: Kagoshima, Kagoshima
country: Japan
facility: National Hospital Organization Kagoshima Medical Center
city: Kanagawa, Kamakura
country: Japan
facility: Shonan Kamakura General Hospital
city: Kumamoto, Kumamoto
country: Japan
facility: Saiseikai Kumamoto Hospital
city: Kumamoto, Kumamoto
country: Japan
facility: Japanese Red Cross Kumamoto Hospital
city: Kumamoto, Kumamoto
country: Japan
facility: Kumamoto City Hospital
city: Kyoto, Uji
country: Japan
facility: Uji-Tokushukai Medical Center
city: Miyagi, Sendai
country: Japan
facility: National Hospital Organization Sendai Medical Center
city: Miyagi, Shibata-gun
country: Japan
facility: South Miyagi Medical Center
city: Nagano, Ina
country: Japan
facility: Ina Central Hospital
city: Nagano, Naganoi
country: Japan
facility: Nagano Municipal Hospital
city: Nagasaki, Nagasaki
country: Japan
facility: Nagasaki University Hospital
city: Osaka, Daito
country: Japan
facility: Nozaki Tokushukai Hospital
city: Osaka, Higashiosaka
country: Japan
facility: Higashiosaka City Medical Center
city: Osaka, Higashiosaka
country: Japan
facility: Wakakusa Daiichi Hospital
city: Osaka, Izumisano
country: Japan
facility: Rinku General Medical Center
city: Osaka, Kishiwada
country: Japan
facility: Kishiwada Tokushukai Hospital
city: Osaka, Osaka
country: Japan
facility: Yagi Neurosurgical Hospital
city: Osaka, Osaka
country: Japan
facility: Tominaga Hospital
city: Osaka, Suita
country: Japan
facility: Osaka University Hospital
city: Saitama, Asaka
country: Japan
facility: TMG Asaka Medical Center
city: Saitama, Hidaka
country: Japan
facility: Saitama Medical University International Medical Center
city: Saitama, Saitama
country: Japan
facility: Sainokuni Higashiomiya Medical Center
city: Saitama, Saitama
country: Japan
facility: Saitama Municipal Hospital
city: Tokyo, Bunkyo-ku
country: Japan
facility: Nippon Medical School Hospital
city: Tokyo, Itabashi-ku
country: Japan
facility: Tokyo Metropolitan Geriatric Hospital
city: Tokyo, Mitaka
country: Japan
facility: Kyorin University Hospital
city: Tokyo, Shinjuku-ku
country: Japan
facility: Tokyo Women's Medical University Hospital
city: Wakayama, Wakayama
country: Japan
facility: Saiseikai Wakayama Hospital
city: Yamagata, Yamagata
country: Japan
facility: Yamagata City Hospital SAISEIKAN
city: Anyang
country: Korea, Republic of
facility: Hallym University Sacred Heart Hospital
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital
city: Daegu
country: Korea, Republic of
facility: Kyungpook National Univ. Hosp
city: Daejoen
country: Korea, Republic of
facility: Chungnam National University Hospital
city: Goyang
country: Korea, Republic of
facility: Inje University Ilsan Paik Hospital
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Hospital
city: Gwangju
country: Korea, Republic of
facility: Chosun University Hospital
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea, Seoul St.Mary's Hospital
city: Seoul
country: Korea, Republic of
facility: Chung-Ang University Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
city: Seoul
country: Korea, Republic of
facility: Kangdong Sacred Heart Hospital
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: SMG-SNU Boramae Medical Center
city: Suwon
country: Korea, Republic of
facility: Ajou University Hospital
city: Kuching
country: Malaysia
facility: Sarawak General Hospital
city: Pulau Pinang
country: Malaysia
facility: Hospital Seberang Jaya
city: Terengganu
country: Malaysia
facility: Hospital Sultanah Nur Zahirah
city: Culiacán
country: Mexico
facility: Hospital General de Culiacán "Dr. Bernardo J. Gastellum"
city: Morelia
country: Mexico
facility: Hospital General "Dr. Miguel Silva"
city: México, D.F.
country: Mexico
facility: Hospital Angeles del Pedregal
city: Nuevo Leon
country: Mexico
facility: Hospital Universitario Dr Jose Eleuterio Gonzalez
city: San Luis Potosi
country: Mexico
facility: H. Central Dr Ignacio M. P.
city: Grafton / Auckland
country: New Zealand
facility: Auckland City Hospital
city: Takpuna Auckland
country: New Zealand
facility: North Shore Hospital, Takapuna
city: Wellington
country: New Zealand
facility: Wellington Hospital
city: Barrios Altos
country: Peru
facility: Instituto Nacional de Ciencias Neurológicas
city: La Victoria
country: Peru
facility: Hospital Nacional Guillermo Almenara Irigoyen
city: Gdansk
country: Poland
facility: PI HOUSE Sp. z o.o., Gdansk
city: Grudziadz
country: Poland
facility: Spec.Hosp.of Dr. Wladyslaw Bieganski in Grudziadz
city: Katowice
country: Poland
facility: Univ.Clin.Centr Gibinski of Silesian Med,Neurol.dep,Katowice
city: Krakow
country: Poland
facility: University Hospital in Krakow
city: Krakow
country: Poland
facility: Center of Clinical Neurology, private prac, Krakow
city: Lublin
country: Poland
facility: Clin.Research Center,Leszek Szczepanski,Private Prac.,Lublin
city: Oswiecim
country: Poland
facility: Medicome Sp. z o.o.
city: Sandomierz
country: Poland
facility: Specialist Holy Spirit Hospital, Neurology Dept,Sandomierz
city: Warsaw
country: Poland
facility: Public Central Clinical Hosp,Neurology Clinic,Warsaw
city: Warsaw
country: Poland
facility: Military Institute of Medicine Neurology Clinic, Warsaw
city: Almada
country: Portugal
facility: Hospital Garcia de Orta, EPE
city: Amadora
country: Portugal
facility: Hospital Fernando Fonseca, EPE
city: Braga
country: Portugal
facility: Hospital de Braga - Centro Clínico Académico (2CA)
city: Coimbra
country: Portugal
facility: CHUC - Centro Hospitalar e Universitário de Coimbra, EPE
city: Lisboa
country: Portugal
facility: CHLC, EPE - Hospital de São José
city: Lisboa
country: Portugal
facility: CHLO, EPE - Hospital Egas Moniz
city: Lisboa
country: Portugal
facility: CHULN, EPE - Hospital de Santa Maria
city: Loures
country: Portugal
facility: Hospital Beatriz Ângelo
city: Matosinhos
country: Portugal
facility: USLM, EPE - Hospital Pedro Hispano
city: Porto
country: Portugal
facility: H. Santo António - Centro Hospitalar do Porto
city: Porto
country: Portugal
facility: Centro Hospitalar São João,EPE
city: Santa Maria da Feira
country: Portugal
facility: Centro Hospitalar de Entre o Douro e Vouga, E.P.E. - Hospital de São Sebastião
city: Kazan
country: Russian Federation
facility: Interreg. Clinical & Diagnostic Center, Neurol. Dept., Kazan
city: Krasnodar
country: Russian Federation
facility: Reg.Clin.Hosp#1 na S.V.Ochapovskiy,Neurology#1 Dep,Krasnodar
city: Kursk
country: Russian Federation
facility: City Clin.Emergency Hosp of Kursk, Neurology Department No.2
city: Moscow
country: Russian Federation
facility: Clin.Hosp#2,na.Semashko,Russ.Railways,Restorative Med&Rehab.
city: Moscow
country: Russian Federation
facility: CityClin.Hosp na I.V.Davydovsky of Dept of Healthcare Moscow
city: Moscow
country: Russian Federation
facility: Research&Clini Cent Neuropsychiatry Dep. Healthcare,Moscow
city: Moscow
country: Russian Federation
facility: City Clin.Hosp#1na N.I.Pirogov,Dept of Healthcare of Moscow
city: Novosibirsk
country: Russian Federation
facility: Ltd liabilityCom.CityNeurologic Cntr Sibneiromed,Novosibirsk
city: Saratov
country: Russian Federation
facility: Saratov State Med.Univ na V.I.Razumovsky,FacultyTherapy Clin
city: Smolensk
country: Russian Federation
facility: Reg.State Instit.of Healthc.Smolensk Reg.Clin.Hosp,Neurology
city: St. Petersburg
country: Russian Federation
facility: Research Inst. of Emerg. Med., Vascul. Center,St. Petersburg
city: St. Petersburg
country: Russian Federation
facility: Military Medical Academy n.a. C. M. Kirov, St. Petersburg
city: Yekaterinburg
country: Russian Federation
facility: Sverdlovsk Reg.Clin.Hosp.No.1
city: Belgrade
country: Serbia
facility: Clinical Center of Serbia
city: Belgrade
country: Serbia
facility: Special Hosp.for Cerebrovascul.Disease,'Sveti Sava,Belgrade
city: Nis
country: Serbia
facility: Clinical Centre Nis
city: Novi Sad
country: Serbia
facility: Clinical Center of Vojvodina
city: Singapore
country: Singapore
facility: National University Hospital
city: Singapore
country: Singapore
facility: Singapore General Hospital
city: Singapore
country: Singapore
facility: National Neuroscience Institute
city: Kosice
country: Slovakia
facility: Faculty Hospital L. Pasteura, Kosice
city: Nitra
country: Slovakia
facility: Faculty Hospital Nitra
city: Dobrna
country: Slovenia
facility: Instit.f.applicative Research in med.rehab.Dobrna
city: Ljubljana
country: Slovenia
facility: Cardial d.o.o., Specialist out-patient unit, Ljubljana
city: Maribor
country: Slovenia
facility: Univ. Medical Center Maribor
city: Pretoria
country: South Africa
facility: University of Pretoria
city: Tongaat
country: South Africa
facility: Dr. Moodley and Dr. Sarvan
city: Albacete
country: Spain
facility: Hospital General Universitario de Albacete
city: Barcelona
country: Spain
facility: Hospital del Mar
city: Barcelona
country: Spain
facility: Hospital Santa Creu i Sant Pau
city: Barcelona
country: Spain
facility: Hospital Vall d'Hebron
city: Girona
country: Spain
facility: Hospital Universitari de Girona Doctor Josep Trueta
city: Lleida
country: Spain
facility: Hospital Arnau de Vilanova
city: Madrid
country: Spain
facility: Hospital La Princesa
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañón
city: Madrid
country: Spain
facility: Hospital Ramón y Cajal
city: Madrid
country: Spain
facility: Hospital Clínico San Carlos
city: Madrid
country: Spain
facility: Hospital La Paz
city: Palma de Mallorca
country: Spain
facility: Hospital Son Espases
city: Pamplona
country: Spain
facility: Complejo Hospitalario de Navarra
city: San Sebastian
country: Spain
facility: Hospital Universitario Donostia
city: Santiago de Compostela
country: Spain
facility: Hospital Clínico de Santiago
city: Sevilla
country: Spain
facility: Hospital Virgen del Rocío
city: Tarragona
country: Spain
facility: Hospital Universitari Joan XXIII
city: Tarrasa (Barcelona)
country: Spain
facility: Hospital Mútua Terrassa
city: Valencia
country: Spain
facility: Hospital Clínico de Valencia
city: Valladolid
country: Spain
facility: Hospital Clínico Universitario de Valladolid
city: Göteborg
country: Sweden
facility: Sahlgrenska US, Göteborg
city: Göteborg
country: Sweden
facility: Sahlgrenska Universitetssjukhuset, Östra
city: Skövde
country: Sweden
facility: Skaraborgs Sjukhus
city: Stockholm
country: Sweden
facility: Karolinska Univ. sjukhuset
city: Stockholm
country: Sweden
facility: Karolinska Univ. sjukhuset
city: Stockholm
country: Sweden
facility: Danderyds Sjukhus
city: Aarau
country: Switzerland
facility: Canton Hospital Aarau, Neurology Dept., Stroke Center
city: Basel
country: Switzerland
facility: University Hospital Basel
city: Bern
country: Switzerland
facility: Univ. Hospital Bern, Neurology Dept, Stroke Center
city: Lausanne
country: Switzerland
facility: CHUV - Centre hospitalier universitaire vaudois
city: Lugano
country: Switzerland
facility: Regional Hospital Lugano,Neurocenter of Southern Switzerland
city: St. Gallen
country: Switzerland
facility: Kantonsspital St.Gallen
city: Zürich
country: Switzerland
facility: University Hosp. Zürich, Dept. of Neurology, Stroke Center
city: Changhua
country: Taiwan
facility: Chang-Hua Christian Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Chang Gung Memorial Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Tainan,
country: Taiwan
facility: Chi Mei Medical Center
city: Tainan
country: Taiwan
facility: NCKUH
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Mackay Memorial Hospital
city: Taipei
country: Taiwan
facility: Cheng Hsin General Hospital
city: Taipei
country: Taiwan
facility: Taipe Veterans General Hospital
city: Taipei
country: Taiwan
facility: Tri-Service General Hospital
city: Taoyuan
country: Taiwan
facility: Chang Gung Memorial Hospital(TaoYuan)
city: Bangkok
country: Thailand
facility: Chulalongkorn University
city: Bangkok
country: Thailand
facility: Ramathibodi Hospital
city: Bangkok
country: Thailand
facility: Siriraj Hospital
city: Lampang
country: Thailand
facility: Lampang Hospital
city: Ankara
country: Turkey
facility: Ankara Universitesi Tip Fakultesi
city: Ankara
country: Turkey
facility: Hacettepe Universitesi Tip Fakultesi Noroloji A.B.D.
city: Ankara
country: Turkey
facility: Gazi Universitesi Tip Fakultesi
city: Eskisehir
country: Turkey
facility: Eskisehir Osmangazi Universitesi Tip Fakultesi
city: Istanbul
country: Turkey
facility: Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi
city: Istanbul
country: Turkey
facility: Istanbul Universitesi Istanbul Tip Fakultesi Noroloji A.B.D.
city: Istanbul
country: Turkey
facility: Istanbul Universitesi Cerrahpasa Tip Fakultesi
city: Istanbul
country: Turkey
facility: Bakırkoy Dr. Sadi Konuk Egitim Ve Arastirma Hastanesi
city: Istanbul
country: Turkey
facility: Bakirkoy Prof. Dr. Mazhar Osman Ruh Sagligi ve Sinir Hastaliklari
city: Istanbul
country: Turkey
facility: Sisli Hamidiye Etfal Egitim ve Arastirma Hastanesi
city: Istanbul
country: Turkey
facility: Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi
city: Izmir
country: Turkey
facility: Dokuz Eylul Universitesi Tip Fakultesi Noroloji A.B.D.
city: Samsun
country: Turkey
facility: Ondokuz Mayis Universitesi Tip Fakultesi
city: Tekirdag
country: Turkey
facility: Namik Kemal Universitesi Tip Fakultesi
city: Chernivtsi
country: Ukraine
facility: Bukovinian Med.Univ.Chernivtsi Reg.Psychiatric Hosp,Neurolog
city: Kharkiv
country: Ukraine
facility: City Clinical Hospital No. 7, Kharkov
city: Kharkiv
country: Ukraine
facility: Instit.of Neurol,Psychiatry&Narcol,Vascul. Malformations Dep
city: Kyiv
country: Ukraine
facility: Instit.of Gerontology na D.F.Chebotarev,Brain Vascular Path.
city: Lviv
country: Ukraine
facility: Lviv Regional Clinical Hospital, Lviv
city: Ternopil
country: Ukraine
facility: Ternopil State Med.Univ.na Gorbachevskiy,Neurology Dept N3
city: Vinnitsia
country: Ukraine
facility: Vinnitsia Reg.Psychoneurol.Hosp.na Yushchenko,Dept.N3,Neurol
city: Zhytomyr
country: Ukraine
facility: Zhytomyr Reg.ClinHosp na Gerbachevskiy RegCouncil,Neurol.Dep
Study officials:
affiliation: Boehringer Ingelheim
name: Boehringer Ingelheim
role: STUDY_CHAIR
References:
citation: Del Brutto VJ, Diener HC, Easton JD, Granger CB, Cronin L, Kleine E, Grauer C, Brueckmann M, Toyoda K, Schellinger PD, Lyrer P, Molina CA, Chutinet A, Bladin CF, Estol CJ, Sacco RL. Predictors of Recurrent Stroke After Embolic Stroke of Undetermined Source in the RE-SPECT ESUS Trial. J Am Heart Assoc. 2022 Jun 7;11(11):e023545. doi: 10.1161/JAHA.121.023545. Epub 2022 Jun 3.
citation: Diener HC, Easton JD, Hart RG, Kasner S, Kamel H, Ntaios G. Review and update of the concept of embolic stroke of undetermined source. Nat Rev Neurol. 2022 Aug;18(8):455-465. doi: 10.1038/s41582-022-00663-4. Epub 2022 May 10.
citation: Bahit MC, Sacco RL, Easton JD, Meyerhoff J, Cronin L, Kleine E, Grauer C, Brueckmann M, Diener HC, Lopes RD, Brainin M, Lyrer P, Wachter R, Segura T, Granger CB; RE-SPECT ESUS Steering Committee and Investigators. Predictors of Atrial Fibrillation Development in Patients With Embolic Stroke of Undetermined Source: An Analysis of the RE-SPECT ESUS Trial. Circulation. 2021 Nov 30;144(22):1738-1746. doi: 10.1161/CIRCULATIONAHA.121.055176. Epub 2021 Oct 15.
citation: Uchiyama S, Toyoda K, Lee BC, Liou CW, Wong LKS, Grauer C, Brueckmann M, Taniguchi A, Urano Y, Easton JD; RE-SPECT ESUS Investigators. Dabigatran or Aspirin in East Asian Patients With Embolic Stroke of Undetermined Source: RE-SPECT ESUS Subgroup Analysis. Stroke. 2021 Mar;52(3):1069-1073. doi: 10.1161/STROKEAHA.120.031891. Epub 2021 Feb 16.
citation: Diener HC, Chutinet A, Easton JD, Granger CB, Kleine E, Marquardt L, Meyerhoff J, Zini A, Sacco RL. Dabigatran or Aspirin After Embolic Stroke of Undetermined Source in Patients With Patent Foramen Ovale: Results From RE-SPECT ESUS. Stroke. 2021 Mar;52(3):1065-1068. doi: 10.1161/STROKEAHA.120.031237. Epub 2021 Jan 28.
citation: Diener HC, Sacco RL, Easton JD, Granger CB, Bar M, Bernstein RA, Brainin M, Brueckmann M, Cronin L, Donnan G, Gdovinova Z, Grauer C, Kleine E, Kleinig TJ, Lyrer P, Martins S, Meyerhoff J, Milling T, Pfeilschifter W, Poli S, Reif M, Rose DZ, Sanak D, Schabitz WR. Antithrombotic Treatment of Embolic Stroke of Undetermined Source: RE-SPECT ESUS Elderly and Renally Impaired Subgroups. Stroke. 2020 Jun;51(6):1758-1765. doi: 10.1161/STROKEAHA.119.028643. Epub 2020 May 14.
citation: Diener HC, Sacco RL, Easton JD, Granger CB, Bernstein RA, Uchiyama S, Kreuzer J, Cronin L, Cotton D, Grauer C, Brueckmann M, Chernyatina M, Donnan G, Ferro JM, Grond M, Kallmunzer B, Krupinski J, Lee BC, Lemmens R, Masjuan J, Odinak M, Saver JL, Schellinger PD, Toni D, Toyoda K; RE-SPECT ESUS Steering Committee and Investigators. Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source. N Engl J Med. 2019 May 16;380(20):1906-1917. doi: 10.1056/NEJMoa1813959.