Clinical trial NCT00929994: Effects of Cardiac Rehabilitation for Individuals With Transient Ischemic Attack
Official title: Effects of Cardiac Rehabilitation for Individuals With Transient Ischemic Attack
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Transient Ischemic Attack
Keywords: cardiac rehab
Lead sponsor: Toronto Rehabilitation Institute
Sponsor class: OTHER
Collaborators: name: Heart and Stroke Foundation of Canada
First posted: 2009-06-30
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: TIA

Brief summary: It is hypothesized that the addition of formal cardiac rehabilitation to standard care will result in long-term improvements in cardiovascular fitness and functional capacity in individuals who have suffered a transient ischemic attack (TIA) or minor stroke.

Furthermore, it is proposed that the addition of cardiac rehabilitation will influence depressive symptoms and cognition.

Detailed description: A transient ischemic attack (TIA) is defined as an episode of neurological dysfunction caused by focal brain ischemia lasting less than 24 hours. Once an individual has suffered a TIA, preventative measures can be taken to target modifiable risk factors, one of which is physical inactivity. The current proposal focuses on the use of an established model of care (cardiac rehabilitation (CR)) and applies it to those who have suffered a TIA in order to maximize physical activity and minimize risk of future cardiovascular events. This will be a one-group pre/post design study with a 3 month non-intervention period. Participants will undergo measures at baseline and 3 months (non intervention period) then after 6 months of cardiac rehabilitation (cardiovascular fitness, 6 minute walk test, cognition, and depressive symptoms).

Eligibility criteria: Inclusion Criteria:

* Diagnosed with TIA
* Three months post-TIA
* Ability to understand the process and instructions for exercise training and provide informed consent

Exclusion Criteria:

* Resting Blood Pressure greater than 160/100 despite medication
* Other cardiovascular morbidity which would limit exercise tolerance (heart failure, abnormal BP responses or STsegment depression \> 2 mm, symptomatic aortic stenosis, complex arrhythmias)
* Current and extensive exercise participation
* Hypertrophic Cardiomyopathy
* Unstable Angina
* Orthostatic BP decrease of \> 20 mm Hg with symptoms
* Other musculoskeletal impairments which would limit the participants ability to walk sufficient durations
* Pain or other co-morbidities (e.g., unclipped aneurysms, uncontrolled seizures etc.) which would preclude participation
* Cognitive or behavioural issues that would limit participation in exercise testing and training

Primary outcomes:
measure: Functional Walk Test
timeFrame: Baseline, 3 months, 6 months (Six Minute Walk Distance)
measure: Cardiovascular Fitness (VO2peak)
timeFrame: Baseline (after the 3 month non-intervention period) and after 6 months of participation.
Secondary outcomes:
measure: Center for Epidemiologic Studies Depression Scale (CES-D).
timeFrame: Baseline and 3 months (non-intervention period), after 6 months of cardiac rehabilitation participation
measure: Cognition
timeFrame: Baseline and 3 months (non-intervention period), after 6 months of cardiac rehabilitation participation
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Toronto Rehabilitation Institute - Rumsey Center
state: Ontario
Study officials:
affiliation: Toronto Rehabilitation Institute
name: Dina Brooks, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Waterloo
name: William E McIllroy, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Toronto Rehabilitation Institute
name: Paul Oh, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Sunnybrook and Women's College Health Centre
name: Sandra Black, MD
role: PRINCIPAL_INVESTIGATOR
References: