Clinical trial NCT04968665: The Mechanism for the Effects of Joint Biomechanical Properties on Medial Cartilage of Tibiofemoral Joint Degeneration
Official title: The Mechanism for the Effects of Joint Biomechanical Properties on Medial Cartilage of Tibiofemoral Joint Degeneration
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Anterior Cruciate Ligament Injuries
Cartilage Degeneration
Keywords: sports biomechanics
joint loading
anterior cruciate ligament reconstruction
cartilage degeneration
functional MRI
Lead sponsor: Peking University Third Hospital
Sponsor class: OTHER
First posted: 2021-07-20
Enrollment: 60
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Thirty patients with ACL rupture undergoing ACL reconstruction surgery at the Institute of Sports Medicine, Peking University Third Hospital would be included in the study cohort were included, A total of 30 healthy volunteers with no history of musculoskeletal system injury or surgery in bilateral lower extremities would be included

Brief summary: Explore The Mechanism for the Effects of Joint Biomechanical Properties on Medial Cartilage of Tibiofemoral Joint Degeneration

Detailed description: Cartilage degeneration in the medial tibiofemoral joint is common after anterior cruciate ligament reconstruction (ACLR), which may develop into knee osteoarthritis (disability rate 21.3%). Alterations in joint biomechanical properties play an important role in cartilage degeneration after ACLR. However, the mechanism remains unclear.

Our research studied the joint kinematics and kinetics properties after ACLR and found significant changes in biomechanics in the ACLR knees. Therefore, this study will combine longitude biochemical changes in the cartilage to explore how the alterations in biomechanics would influence biochemical changes in the joint cartilage.

This study will explore the joint biomechanical properties during functional activities by motion analysis, the effects of biomechanical properties on cartilage stress distribution by finite element analysis, the long-term biochemical changes in the joint cartilage by functional MRI. This study will establish prediction models for cartilage biomechanical changes in the mid-term based on joint biomechanical properties in the early stage after ACLR, and cartilage biomechanical changes in the long-term based on joint biomechanical properties in the mid-term after ACLR. The study aims to clarify the mechanism of cartilage degeneration after ACLR and search biomechanical risk factors, in order to provide methods for clinical prevention of cartilage degeneration after ACLR.

Eligibility criteria: Inclusion Criteria:

Unilateral ACL rupture of the knee

Exclusion Criteria:

concomitant with other ligament injury or rupture, with history of surgery or musculoskeletal system injury of the contralateral knee, and the time from injury to operation more than 8 weeks

Primary outcomes:
measure: knee T1 rho value
timeFrame: On the day of enrollment.
measure: knee T1 rho value
timeFrame: At 6 months post operation.
measure: knee T1 rho value
timeFrame: At 12 months post operation.
measure: knee T1 rho value
timeFrame: At 2 years post operation.
measure: knee T2 value
timeFrame: On the day of enrollment.
measure: knee T2 value
timeFrame: At 6 months post operation.
measure: knee T2 value
timeFrame: At 12 months post operation.
measure: knee T2 value
timeFrame: At 2 years post operation.
measure: knee extension angles
timeFrame: On the day of enrollment.
measure: knee extension angles
timeFrame: At 6 months post operation.
measure: knee extension angles
timeFrame: At 12 months post operation.
measure: knee extension angles
timeFrame: At 2 years post operation.
measure: knee moments
timeFrame: On the day of enrollment.
measure: knee moments
timeFrame: At 6 months post operation.
measure: knee moments
timeFrame: At 12 months post operation.
measure: knee moments
timeFrame: At 2 years post operation.
measure: ground reaction force
timeFrame: On the day of enrollment.
measure: ground reaction force
timeFrame: At 6 months post operation.
measure: ground reaction force
timeFrame: At 12 months post operation.
measure: ground reaction force
timeFrame: At 2 years post operation.
measure: knee rotation angles
timeFrame: On the day of enrollment.
measure: knee rotation angles
timeFrame: At 6 months post operation.
measure: knee rotation angles
timeFrame: At 12 months post operation.
measure: knee rotation angles
timeFrame: At 2 years post operation.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Peking University Third Hospital
name: Shuang Ren
role: PRINCIPAL_INVESTIGATOR
References: