louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00585767: Functional, Dynamic, and Anatomic MR Urography
Official title: Functional, Dynamic, and Anatomic MR Urography
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Hydronephrosis
Keywords: Hydronephrosis
Lead sponsor: University of California, Davis
Sponsor class: OTHER
First posted: 2008-01-03
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who have been diagnosed with obstructive uropathy

Brief summary: This is a clinical feasibility study to assess the value of MR imaging for obtaining functional, dynamic and anatomical information in a comprehensive imaging protocol in subjects having obstructive uropathy.


Eligibility criteria: Inclusion Criteria:

* Males or females 18 years of age or older.
* All female patients of childbearing potential must agree to use a medically accepted method of contraception at the time of the study.
* Patients must have the ability to understand the requirements of the study, provide written and informed consent to participate, and agree to abide by the study requirements.
* Patients who have known or suspected hydronephrosis or patients with solitary kidneys.

Exclusion Criteria:

* Patients with known or suspected hypersensitivity to gadolinium-based agents.
* Patients who are pregnant or lactating.
* Patients with a condition that is a contraindication to MRI (e.g., cardiac pacemaker, epicardial pacemaker leads, cochlear implants, ferromagnetic aneurysm clip, ferromagnetic halo device, or other conditions that would preclude patient proximity to a strong external magnetic field).
* Patients with a recent history of hemolytic anemia, sickle cell anemia or other hemoglobinopathy.
* Patients with a history of significant claustrophobia.
* Patients with impaired renal function based on 24-hr urine collection (creatinine clearance \<10 ml/min or serum creatinine \>1.8 mg/dl)

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University of California, Davis
name: Richard Katzburg, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06321367: Model to Predict Coinfection in Elderly Patients With COVID-19
Official title: Construction and Validation of a Predictive Model of Coinfections in Elderly COVID-19 Patients After Abandoning Zero Policy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Covid19
Keywords: COVID-19
elderly
nomogram
coinfections
diagnosis
Lead sponsor: Xiangya Hospital of Central South University
Sponsor class: OTHER
First posted: 2024-03-20
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Elderly COVID-19 patients admitted into Xiangya Hospital of Central South University (in Changsha, Hunan) and Xiangya Hospital of Central South University, Jiangxi (in Nanchang, Jiangxi)

Brief summary: The goal of this observational study is to learn about the clinical characteristics and construction of a predictive model in elderly COVID-19 patients. The main question it aims to answer is the main clinical characteristics and risk factors of elderly COVID-19 patients. Participants will not be asked to do any other intervening measure.


Eligibility criteria: Inclusion Criteria:

* Age greater than or equal to 65 years old;
* COVID-19 was diagnosed with SARS-CoV-2 reverse transcription-polymerase chain reaction positive or rapid antigen test positive or a clinical diagnosis made by the radiological responsible clinician based on signs, symptoms, or radiology consistent with COVID-19;
* Hospitalization more than one day, including patients in emergency.

Exclusion Criteria:

* Age less than 65 years old;
* Pregnancy;
* Hospitalization less than one day;
* Outpatients;
* Patients with missing or incomplete information.

Primary outcomes:
measure: Coinfection
timeFrame: from admission to 7 days after admission
Secondary outcomes:
Other outcomes:
Locations:
city: Changsha
country: China
facility: Xiangya Hospital of Central South University
state: Hunan
Study officials:
References:
Clinical trial NCT01663467: Efficacy of Internet and Smartphone Application-delivered Tinnitus Retraining Therapy
Official title: Efficacy of Internet and Smartphone Application-delivered TRT
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Tinnitus
Keywords: tinnitus
smartphone
Web
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: Soonchunhyang University Hospital
First posted: 2012-08-13
Enrollment: 0
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to prove the efficacy of the internet and smartphone application-delivered tinnitus retraining therapy (TRT).

Detailed description: to investigate the effect of TRT with minimized counseling

Eligibility criteria: Inclusion Criteria:

* chronic subjective tinnitus

Exclusion Criteria:

* THI \< 18

Primary outcomes:
measure: Tinnitus Handicap Inventory (THI)
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: YOUNG HO KIM, MD., PhD
role: STUDY_CHAIR
References:
Clinical trial NCT03476967: Effect of Laser Treatment for Diabetic Retinopathy on the Optic Disc Topography
Official title: Effect of Panretinal Photocoagulation on Confocal Laser Scanning Ophthalmoscopy and Stereo Photographic Parameters of the Optic Disc Topography in Diabetic Retinopathy Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Diabetic Retinopathy
Keywords: optic disc topography
panretinal photocoagulation
confocal scanning laser ophthalmoscopy
stereoscopic disc photographs
diabetic retinopathy
optic nerve head parameters
Lead sponsor: University of Sao Paulo General Hospital
Sponsor class: OTHER
Collaborators: name: Conselho Nacional de Desenvolvimento Científico e Tecnológico
First posted: 2018-03-26
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients followed in the ophthalmology department of Hospital das Clínicas da FMUSP who have type I or II diabetes mellitus and present severe or very severe non proliferative diabetic retinopathy or proliferative diabetic retinopathy in cases where retinal panphotocoagulation is indicated.

Brief summary: This study analyzed diabetic patients without evidence of glaucoma who underwent panretinal photocoagulation to determine the effect on optic disc topographic parameters in non-glaucomatous patients with proliferative diabetic retinopathy (PDR).

Detailed description: Glaucoma and proliferative diabetic retinopathy (PDR) are two very prevalent diseases that often coexist. Previous literature suggest that panretinal photocoagulation may somehow lead to optic disk cupping. Therefore, evaluation of the optic disc cupping and of possible glaucomatous damage in patients with diabetic retinopathy can be difficult, especially after PRP treatment. The purpose of this study is to determine the long-term effect of PRP on optic disc topographic parameters in non-glaucomatous patients with PDR using Heidelberg retina tomograph (HRT) parameters and stereo photography. The Investigators found that PRP does not cause morphological optic disk changes in diabetic PDR patients after one year of follow-up.

Eligibility criteria: Inclusion Criteria:

* diagnosis of PDR (due to type 1 or 2 diabetes mellitus)
* intraocular pressure \< 18 mmHg
* nonglaucomatous optic disc characteristics at fundus examination
* vertical cup-to-disc (C/D) ratio \<0.7
* absence of media opacities

Exclusion Criteria:

* previous diagnosis of glaucoma
* family history of glaucoma
* neuroophthalmic disease
* uveitis
* retinal artery or vein occlusion
* optic disc neovascularization
* diabetic macular edema (DME)
* corneal opacity
* previous laser photocoagulation treatment

Primary outcomes:
measure: Cup area
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil
name: Leandro Zacharias
role: STUDY_DIRECTOR
References:
Clinical trial NCT04422067: Usefulness of Cephalometry in the Second and Third Trimester of Pregnancy in the Diagnosis of Fetal Microretrognathia
Official title: Usefulness of Cephalometry in the Second and Third Trimester of Pregnancy in the Diagnosis of Fetal Microretrognathia : Prenatal Cephal
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pierre Robin Sequence
Keywords: with one or more fetuses suffering from a microretrognathia
Cephalometry
Prenatal Diagnosis
Facial angles
Fetal echography
Microretrognathia
diagnosed prenatally
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2020-06-09
Enrollment: 68
Sex: ALL
Minimum age (years): 18
Maximum age (years): 44
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All pregnant patients with one or more fetuses suffering from a microretrognathia, diagnosed prenatally and integrated into a Pierre Robin Sequence

Brief summary: Congenital retrognathia, with or without Pierre Robin Sequence (PRS), is a rare anomaly which can be associated with chromosomal abnormalities. Respiratory and feeding consequences can be present at birth. After birth, the diagnosis of retrognathia is based on the clinical examination. Cephalometry can be used to complete the diagnosis. Several authors have proposed the use of objective quantitative ultrasound parameters for the antenatal screening of PRS. In our study, the investigators evaluated fetal cephalometry.

The aim First, the investigators studied the inter- and intra-observer reproducibility of cephalometry. Second, the investigators established reference values for antenatal cephalometry in normal fetuses. Third, the investigators compared the diagnostic performance of cephalometry and the other angles described in the literature for the diagnosis of retrognathia.


Eligibility criteria: Inclusion criteria:

* Pregnant patient (Aged \>18years old)
* with one or more fetuses suffering from a microretrognathia
* diagnosed prenatally
* integrated into a Pierre Robin Sequence

Exclusion criteria:

* Uncvertain diagnosis
* Absence of 3D rendering volume

Primary outcomes:
measure: Reproducibility of cephalometry
timeFrame: During ultrasound
Secondary outcomes:
measure: Perfomance of several angle to diagnose retrognatism
timeFrame: During ultrasound
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
affiliation: University Hospital, Montpellier
name: Florent FUCHS, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00233467: Characterization of the Use of Antipsychotics in Posttraumatic Stress Disorder During the Past Decade
Official title: Characterization of the Use of Antipsychotics in Posttraumatic Stress Disorder During the Past Decade
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: PTSD
Posttraumatic Stress Disorder
Keywords: antipsychotics
PTSD
posttraumatic stress disorder
Lead sponsor: Tuscaloosa Research & Education Advancement Corporation
Sponsor class: OTHER
First posted: 2005-10-05
Enrollment: 0
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Chart review of Veterans on antipsychotics

Brief summary: The main purpose is to show the percentage of patients taking antipsychotics with PTSD by looking at approximately ten year's worth of data from 1994 through 2004. We will also determine the type and dose of antipsychotics the patients received, and to determine how many of those patients had psychotic versus nonpsychotic symptoms. We will be obtaining this data from the VISN 7 Corporate Data Warehouse. We hypothesize that there has been an overall increase in antipsychotic use in patient's with PTSD over the last 10 years.

Detailed description: This study is a retrospective chart review of patients, at the Tuscaloosa VA Medical Center, who were, treated with antipsychotics as monotherapy or adjunctive therapy.

The data will be retrieved from a computerized list of patients treated at the TVAMC for PTSD from 1994-2004 Charts will be reviewed by looking at approximately ten year's worth of data. Charts will then be examined to determine what type of antipsychotics patients were prescribed, the dose and duration of the antipsychotics, and the presence or absence of documented psychotic symptoms.

Eligibility criteria: Inclusion Criteria:

1. Have a diagnosis of PTSD (309.81)
2. Male or female patients at least 19 years of age

Exclusion Criteria:

• None

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Tuscaloosa
country: United States
facility: Tuscaloosa VA Medical Center
state: Alabama
Study officials:
affiliation: Tuscaloosa Veterans Affairs Medical Center
name: Rebecca Seamans, PharmD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kozaric-Kovacic D, Pivac N, Muck-Seler D, Rothbaum BO. Risperidone in psychotic combat-related posttraumatic stress disorder: an open trial. J Clin Psychiatry. 2005 Jul;66(7):922-7. doi: 10.4088/jcp.v66n0716.
Clinical trial NCT04477967: Design and Implementation of the Pediatric Liver Transplantation Biobank
Official title: Children's Hospital of Chongqing Medical University
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Liver Diseases
Liver Transplant; Complications
Pediatric ALL
Lead sponsor: Children's Hospital of Chongqing Medical University
Sponsor class: OTHER
First posted: 2020-07-20
Enrollment: 500
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children with end-stage liver disease who undergo liver transplantation in our hospital. Obtain their or their parents' informed consent before the project starts.

Brief summary: The purpose of the pediatric liver transplant biobank is to systematically collect clinical specimens from pediatric end-stage liver disease. It is expected to contribute to the research and development of paediatric end-stage liver disease in the future.


Eligibility criteria: Inclusion Criteria:

1. Children diagnosed with end-stage liver disease.
2. Liver transplantation in our hospital.
3. informed patient consent.
4. long-term follow-up in our hospital.

Exclusion Criteria:

No fixed contact information, difficult to follow up the patients.

Primary outcomes:
measure: Biological sample bank
timeFrame: 2 years
measure: Integrated health data platform
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Chongqing
country: China
facility: Children's Hospital of Chongqing Medical University
state: Chongqing
Study officials:
References:
citation: Xiang Z, Wang R, Lu Y, Li Y, Wang H, Xiong Q, Dai X, Guo H, Deng Y, Le Y, Zhang M, Zhao Y. Study Protocol: Design and Implementation of the Pediatric Liver Transplantation Biobank. Biopreserv Biobank. 2021 Apr;19(2):111-118. doi: 10.1089/bio.2020.0128. Epub 2021 Apr 12.
Clinical trial NCT01872767: Spectrum, Profile and Outcome of Infections in Patients With Cirrhosis and/ or Acute on Chronic Liver Failure
Official title: Spectrum, Profile and Outcome of Infections in Patients With Cirrhosis and/ or Acute on Chronic Liver Failure Admitted in Liver Specialty ICU (Intensive Care Unit)- An Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cirrhosis
Acute Liver Failure
Chronic Liver Failure
Keywords: Acute on Chronic Liver Failure (ACLF),Cirrhosis,
Institute of Liver & Biliary Sciences (ILBS)
Lead sponsor: Institute of Liver and Biliary Sciences, India
Sponsor class: OTHER
First posted: 2013-06-07
Enrollment: 522
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Tertiary Care Center.

Brief summary: After successful screening diagnosis of cirrhosis and/or acute or chronic liver failure will be made. These patients will undergo detail clinical, biochemical and microbiological examination at baseline. Clinical examination and Biochemical evaluation will be done daily and signs of infection will be noted. Patients will undergo microbiological screening for infection every 48 hours. Patients suspected or diagnosed to be suffering from infections will be treated as per ILBS (Institute of Liver and Biliary Sciences) antibiotic policy. Site and etiology (bacterial and/or fungal) of infections will be noted in all patients at admission in liver specialty ICU (Intensive Care Unit) and during the ICU (Intensive Care Unit) stay. All the patients will be followed until discharge or death in ICU (Intensive Care Unit).


Eligibility criteria: Inclusion Criteria:

* A clinical, radiological or histological diagnosis of cirrhosis and/or ACLF (Acute on Chronic Liver Failure).
* Age \> 18years

Exclusion Criteria:

* Previous liver transplantation.
* Patients who died within 8 hours of ICU (Intensive Care Unit) admission.
* Acute liver failure
* Lack of consent
* Patient on steroids/ or any other immunosuppressive medication

Primary outcomes:
measure: Mortality within 1 month during ICU (Intensive Care Unit) stay.
timeFrame: 30 days
Secondary outcomes:
measure: Number of days stayed in ICU (Intensive Care Unit).
timeFrame: 30 days
measure: Risk factors determination in development of multidrug resistance bacteria.Risk factors are defined as Nosocomial infection,Recent Hospitalization, recent antibiotic usage, SBP (spontaneous bacterial peritonitis)prophylaxis, diabetes etc
timeFrame: 30 days
measure: Proportion of patients with organ failure.
timeFrame: 30 days
Other outcomes:
Locations:
city: New Delhi
country: India
facility: Institute of Liver & Biliary Sciences.
state: Delhi
Study officials:
affiliation: Institute of Liver & Biliary Sciences.
name: Amrish Sahney, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03198767: Effects of Carbohydrate in Diet and Supplements on the Gastrointestinal Tolerability of LIK066
Official title: A Randomized, Open Label, Two-part, Three-period, Cross Over Study to Investigate the Effects of Carbohydrate in Diet and to Evaluate Supplements on the Gastrointestinal Tolerability of LIK066 in Overweight or Obese Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Obesity
Keywords: obesity
overweight
body mass index
BMI
diarrhea
Lead sponsor: Novartis
Sponsor class: INDUSTRY
First posted: 2017-06-26
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study was to determine if LIK066 taken with a meal containing low carbohydrate is associated with less diarrhea compared to a high carbohydrate meal and to assess the potential effects of supplements such as psyllium or calcium carbonate on alleviating diarrhea associated with LIK066.


Eligibility criteria: Inclusion Criteria:

* obese and overweight, BMI 25-50, HbA1C \<10%

Exclusion Criteria:

* Preexisting, clinically significant cardiovascular, liver, renal, or GI disease that is considered unstable; pregnancy, Type 1 diabetes; Other protocol-defined inclusion/exclusion criteria may apply

Primary outcomes:
measure: Number of Episodes of Diarrhea (Part A and Part B)
timeFrame: 24 hours on Day 3 of each treatment period
Secondary outcomes:
measure: Three-day Total Number of Episodes of Diarrhea (Part A and Part B)
timeFrame: Day 1 to 3 of each treatment period
measure: Average Consistency With Bristol Stool Chart (Part A and Part B)
timeFrame: 24 hours on Day 3 of each treatment period
measure: Average Stool pH (Part A and Part B)
timeFrame: 24 hours on Day 3 of each treatment period
measure: Average Stool Weight (Part A and Part B)
timeFrame: 24 hours on Day 3 of each treatment period
Other outcomes:
Locations:
city: Lincoln
country: United States
facility: Novartis Investigative Site
state: Nebraska
Study officials:
affiliation: Novartis Pharmaceuticals
name: Novartis Pharmaceuticals
role: STUDY_DIRECTOR
References:
Clinical trial NCT06866067: The Effect of Clip Material on the Retention of Implant Supported Mandibular Overdenture
Official title: The Effect of Clip Material on the Retention of Implant Supported Mandibular Overdenture: Clinical Comparative Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Denture Retention
Lead sponsor: MTI University
Sponsor class: OTHER
First posted: 2025-03-10
Enrollment: 12
Sex: MALE
Minimum age (years): 50
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is aiming to evaluate the retention of implant supported mandibular overdenture using two different clip materials namely polyoxymethylene (POM) and poly-ether-ether-ketone (PEEK) on PEEK bar at three-time intervals; immediately after placement, after 3 months and after 6 months.


Eligibility criteria: Inclusion Criteria:

* Inclusion criteria:

  * Male.
  * Completely edentulous.
  * Age: 50-60 years.
  * Free from any systemic diseases that affect bone metabolism.
  * Good intraoral condition.
  * Anterior mandibular bone height \> 13mm and width \> 5mm.
  * The inter-arch space from 15mm to 17mm.

Exclusion criteria:

* Smoking and drug abusing.
* Severe maxillomandibular skeletal discrepancy.
* Bone metabolic disorders.
* History of head and neck radiotherapy.
* Intravenous bisphosphonate therapy.
* Presence of para-functional habits.
* Temporomandibular joint disorders.
* Severe bony undercuts.

Primary outcomes:
measure: Overdenture retention assessed using Universal Testing Machine (Newton)
timeFrame: From enrollment and after 3 months and finally at the end of treatment at 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: MTI University
Study officials:
References: