Clinical trial NCT06270004: Effect of Nonsurgical Periodontal Therapy on Salivary Biomarkers Related to Bone Turnover in Smoker and Nonsmoker Periodontitis Patients
Official title: Effect of Nonsurgical Periodontal Therapy on Salivary Biomarkers Related to Bone Turnover in Smoker and Nonsmoker Periodontitis Patients
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Non Surgical Periodontal Therapy
Keywords: osteonectin
osteopontin
histatin1
Lead sponsor: University of Baghdad
Sponsor class: OTHER
First posted: 2024-02-21
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: smoker and non smoker patients with unstable periodontitis
Primary purpose: OTHER

Brief summary: 1. To assess the alteration in the level of salivary osteopontin (OPN), osteonectin(ON) and histatin-1 following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals(one month and three months) .
2. To evaluate the response of clinical periodontal parameters ( plaque index ,bleeding on probing ,probing pocket depth ,clinical attachment loss)following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals (one month and three months)

Detailed description: the study include nonsurgical periodontal therapy for smoker and non smoker patients with unstable periodontitis and evaluate the clinical periodontal parameters ( plaque index, bleeding on probing , probing pocket depth ,clinical attachment loss) and assess the alteration in the level of salivary osteopontin (OPN), osteonectin(ON) and histatin-1 following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals(one month and three months)

Eligibility criteria: Inclusion Criteria:

* participants will be systemically healthy without history of any systemic diseases.
* hadn't underwent periodontal treatment during the previous 6 months and not taken medication during the previous 3 months.
* present with at least 20 teeth, those who only diagnosed with 4-6 mm probing pocket depth, generalized ,unstable periodontitis who had bone loss \> 30% , probing probing pocket depth at ≥4mm . Periodontitis cases were defined if clinical attachment loss was detected at ≥2 non- adjacent teeth or when buccal (facial) showed clinical attachment loss ≥3mm associated with probing pocket depth \>3mm at ≥ 2 teeth .
* The patients in the smokers group will be current smokers ( cigarette smokers) with smoking habit for over 3 years

Exclusion Criteria:

* Subjects have any intraoral plaque retentive factors such as those wearing partial denture, crown and bridges, and orthodontic appliances ,furcation involved teeth, overhang filling, tooth anomaly.
* receiving antibiotic therapy during the previous 3 months.
* those with systemic diseases such as diabetes mellitus, cardiovascular or renal diseases, etc...., pregnant or lactating women, not willing to participate or continue to conduct the study.

Primary outcomes:
measure: Effect of nonsurgical periodontal therapy(NSPT) on salivary biomarkers related to bone turnover in smoker and nonsmoker periodontitis patients.
timeFrame: baseline, one month and three months
Secondary outcomes:
measure: Effect of nonsurgical periodontal therapy(NSPT) on salivary biomarkers related to bone turnover in smoker and nonsmoker periodontitis patients.
timeFrame: baseline, one month and three months
measure: Effect of nonsurgical periodontal therapy(NSPT) on salivary biomarkers related to bone turnover in smoker and nonsmoker periodontitis patients
timeFrame: baseline, one month and three months
Other outcomes:
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