Clinical trial NCT06647667: High Interval Versus Moderate Intensity Continuous Training on Soluble st2 Biomarkers in Chronic Heart Failure
Official title: High Interval Versus Moderate Intensity Continuous Training on Soluble st2 Biomarkers in Chronic Heart Failure
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Heart Failure
Keywords: sST2 biomarker
Minnesota Questionare
HIITS
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-10-18
Enrollment: 60
Sex: MALE
Minimum age (years): 50
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 1. Patients will receive high intensity interval training (HIIT)
2. Patients will receive moderate intensity continuous training (MICT)
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study was designed to compare between the effect of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on soluble ST2 biomarkers among chronic heart failure patients, also measure the improvement in the quality of life with different modes of exercise and with of it is more benifitial for the heart failure patient

Detailed description: The data concerned with the study including soluble ST2 biomarker levels, ejection fraction and MLHFQ was measured before and after twelve weeks of treatment.In this study a total sixty male patients with chronic heart failure NYHA class (I \&II) were selected from the outpatient clinic, El-Demerdash hospital, Ain-shams University. Their age ranged from 50-60 years. Patients were randomly assigned into two groups, group A receiving HIIT along with prescribed medical treatment and group B receiving MCT along with prescribed medical treatment.

Eligibility criteria: Inclusion Criteria:

* The patients selection was according to the following criteria:

  * Patients diagnosed with chronic heart failure (New York heart association class I\& II) with systolic left ventricular dysfunction.
  * Their left ventricular ejection fraction (LVEF) \<40%.
  * Medical treatment was optimized at least three months prior to study entry.
  * All patients didn't participate in any rehabilitation programs prior to the study.

Exclusion Criteria:

* Patients who had met one of the following criteria were excluded from the study:

  1. Signs of acute heart failure, unstable angina or severe arrhythmia three months prior to enrolment in the study.
  2. Pacemakers.
  3. Chronic obstructive pulmonary disease.
  4. Other disorders counteracting exercise testing conditions that limit lower limb mobility (for example, burns, fractures)
  5. Pre-existing neuromuscular diseases (for example Myasthenia Gravis).

Primary outcomes:
measure: soluble ST2 biomarker level
timeFrame: before the start of the trail and at the end of the trail 3 months
Secondary outcomes:
measure: ejection fraction
timeFrame: before the start of the trail and at the end of the trail 3 months
measure: mannisota of daily living questionnaire score
timeFrame: before the start of the trail and at the end of the trail 3 months
measure: peak exercise response
timeFrame: before the start of the trail and at the end of the trail 3 months
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Faculty of physical therapy Cairo University
Study officials:
affiliation: Cairo University
name: Donia M Elmasry, Doctorate
role: STUDY_DIRECTOR
References: