Clinical trial NCT06756230: Downhill Walking in IPF
Official title: Effects of Downhill Walking in Pulmonary Rehabilitation for Patients With Idiopathic Pulmonary Fibrosis
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Idiopathic Pulmonary Fibrosis (IPF)
Keywords: IPF
eccentric exercise training
pulmonary rehabilitation
Lead sponsor: Saglik Bilimleri Universitesi
Sponsor class: OTHER
First posted: 2025-01-01
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study; will examine the effects of downhill walking (eccentric exercise training) on exercise capacity, quality of life, and blood lactate levels in individuals with IPF. After the initial assessment, patients will be randomized into two groups: downhill walking PR group and Standard PR Group.

Detailed description: Individuals diagnosed with idiopathic pulmonary fibrosis who come to the Pulmonary Rehabilitation Unit of Istanbul Süreyyapaşa Chest Diseases and Chest Surgery Education and Research Hospital will be included in this study. Those who meet the inclusion criteria will be randomized into two groups: Downhill Walking Pr Group (n=17) and Standard Pr Group (n=17). Patients will have exercise sessions twice a week for 8 weeks. Patients will be evaluated immediately before the rehabilitation program and the end of 8 weeks exercise programme. In our study, downhill walking training will differ from traditional walking training only in terms of treadmill training protocol. Traditional walking training involves walking on a motorized treadmill with a neutral incline, progressing with increases in speed, while downhill walking training will be performed at a constant -10% incline.

Eligibility criteria: Inclusion Criteria:

* Having a diagnosis of IPF according to the clinical diagnostic criteria of the American Thoracic Society and/or the European Respiratory Society (ATS-ERS).
* Being between the ages of 18 and 75.
* Being able to walk on a treadmill.
* Having the ability to cooperate.
* No change in current medication in the last month.
* Not participating in a structured activity program for at least six months.
* Accepting the purpose and method of this study voluntarily and give informed consent for the study.

Exclusion Criteria:

* Presence of physical or mental impairment that prevents informed consent or compliance with the protocol.
* Inability to attend more than 20% of pulmonary rehabilitation sessions.
* Presence of major cardiovascular disease (coronary artery disease, uncontrolled hypertension, arrhythmias, or heart failure).
* Presence of existing orthopedic and neuromuscular exercise limitations.
* Acute exacerbation

Primary outcomes:
measure: 6 Minutes Walking Distance (6MWD)
timeFrame: Baseline and the end of the 8 weeks exercise program
measure: Saint George Quality of life questionnaire
timeFrame: Baseline and the end of the 8 weeks exercise program
Secondary outcomes:
measure: Spirometric measurements (Forced vital capacity)
timeFrame: Baseline and the end of the 8 weeks exercise program
measure: Spirometric measurements (First second forced expiratory volume)
timeFrame: Baseline and the end of the 8 weeks exercise program
measure: Spirometric measurements (FEV1/FVC ratio)
timeFrame: Baseline and the end of the 8 weeks exercise program
measure: Peripheral muscle strength
timeFrame: Baseline and the end of the 8 weeks exercise program
measure: Hand grip strength
timeFrame: Baseline and the end of the 8 weeks exercise program
measure: Modified Medical Research Council Dyspnea Score
timeFrame: Baseline and the end of the 8 weeks exercise program
measure: Fatigue severity scale
timeFrame: Baseline and the end of the 8 weeks exercise program
measure: Hospital anxiety depression scale (HADS)
timeFrame: Baseline and the end of the 8 weeks exercise program
measure: Determination of blood lactate level
timeFrame: Baseline and the end of the 8 weeks exercise program
measure: Carbon monoxide diffusion capacity
timeFrame: Baseline and the end of the 8 weeks exercise program
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Saglik Bilimleri Universitesi
state: Üsküdar
Study officials:
References: