Clinical trial NCT03088891: Effect of an Antioxidant-rich Diet During Moderate Altitude Training
Official title: The Effect of an Increased Intake of Antioxidant-rich Foods on Training Adaptation, Redox-balance and Inflammation Among Elite Athletes During a Moderate Altitude Training Camp
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Oxidative Stress
Adaptation Reaction
Inflammation
Keywords: altitude training
antioxidants
oxidative stress
elite athletes
inflammation
diet
Lead sponsor: University of Oslo
Sponsor class: OTHER
Collaborators: name: Norwegian School of Sport Sciences
name: Norwegian Olympic Federation, Oslo, Norway
First posted: 2017-03-23
Enrollment: 35
Sex: ALL
Minimum age (years): 16
Maximum age (years): 42
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Athletes, especially in endurance sports, are at increased risk of oxidative stress and inflammation-related diseases and injuries. The production of reactive oxygen and nitrogen species (RONS) and inflammatory markers increase during exercise and especially during altitude training. Antioxidant supplementation is commonly used among athletes in the belief that it prevents oxidative stress and oxidative damage. A transient increase of RONS is however necessary to activate signaling cascades initiating training adaptation. Antioxidant supplementation has been shown to inhibit the exercise effects in several independent studies, possibly by interfering/reducing the signal cascades initiated by RONS. However, it is unknown whether a high intake of antioxidant rich foods can affect the amount of RONS, inflammation markers and/or training adaptation. The investigators want to examine whether an increased intake of natural antioxidants in the form of antioxidant-rich foods fruits, vegetables and berries, in line with the official Norwegian dietary advice can affect antioxidant status, immune function and training adaptation associated with altitude training in Norwegian elite athletes.


Eligibility criteria: Inclusion Criteria:

* National team athletes, summer endurance sports

Exclusion Criteria:

* Allergies in conflict with the intervention foods
* Use of medication that could affect training and performance
* Injuries that could affect training and performance

Primary outcomes:
measure: Percent change in performance (sport specific tests will be aggregated to one outcome by the use of percent change)
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: Training adaptation
timeFrame: Measured one week before, and one week after the moderate altitude training camp
measure: Training adaptation for swimmers
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Secondary outcomes:
measure: Change in biomarkers of inflammation
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: change in lean body mass
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: Bone mineral density
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: change in fat mass
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: change in body composition
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: change in body weight
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: Dietary intake (change in food and nutrient intake)
timeFrame: Measured one and three week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: Change in antioxidant status
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: biomarkers of antioxidant-rich foods
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: Change in whole blood gene expression
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: Change in blood lipids
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: Change hormones
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: Change in micronutrients
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: change response to stress test
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: Change in hemoglobin
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: change in blood volume
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: change in plasma volume
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: Change in lactate
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
measure: Total training load
timeFrame: Measured one week before, during (in week 1 and 3 of the camp) and one week after the moderate altitude training camp
Other outcomes:
Locations:
city: Oslo
country: Norway
facility: University of Oslo
city: Oslo
country: Norway
facility: Norwegian Olympic Federation
Study officials:
References:
citation: Koivisto-Mork AE, Paur I, Paulsen G, Garthe I, Raastad T, Bastani NE, Blomhoff R, Bohn SK. Dietary Adjustments to Altitude Training in Elite Endurance Athletes; Impact of a Randomized Clinical Trial With Antioxidant-Rich Foods. Front Sports Act Living. 2020 Aug 26;2:106. doi: 10.3389/fspor.2020.00106. eCollection 2020.