Clinical trial NCT04239794: The Influence of Type of Anesthesia on Postoperative Pain
Official title: The Influence of Type of Anesthesia on Postoperative Pain After Laparoscopic Colorectal Cancer Surgery: Multi-center Prospective Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Colo-rectal Cancer
Anesthesia
Keywords: Postoperative pain
Opioid consumption
Intraoperative anesthesia
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2020-01-27
Enrollment: 468
Sex: ALL
Minimum age (years): 19
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The investigators designed a multi-center prospective randomized controlled trial to study the influence of the type of anesthesia on postoperative pain after laparoscopic colorectal cancer surgery. Half of the participants will be anesthetized with propofol and remifentanil, while the other half will be anesthetized with sevoflurane and remifentanil during the surgery. The investigators will measure opioid consumption and pain score in the acute postoperative phase.

Detailed description: Previous studies showed that patients receiving total intravenous anesthesia (TIVA) with propofol are associated with less postoperative pain and less opioid consumption compared with inhalation anesthesia. However, some studies showed conflicting results. In colorectal surgery, there are only retrospective studies that showed the analgesic effect of TIVA and inhalation anesthesia. The investigators designed a multi-center prospective randomized controlled trial and hypothesized that TIVA with propofol would be associated with reduced postoperative opioid consumption and less postoperative pain compared with sevoflurane in laparoscopic colorectal cancer surgery.

Eligibility criteria: Inclusion Criteria:

* Adult patient scheduled for elective laparoscopic colorectal cancer surgery

Exclusion Criteria:

* Pregnant
* Conversion from laparoscopic to open surgery
* Allergy to anesthetics and analgesics
* Previous abdominal surgery
* Chronic pain
* Chronic analgesic usage

Primary outcomes:
measure: Postoperative 24 h opioid consumption
timeFrame: 24 hours after the surgery
Secondary outcomes:
measure: Postoperative 48 h opioid consumption
timeFrame: 48 hours after the surgery
measure: Numerical rating scale (NRS)
timeFrame: 24 and 48 hours after the surgery
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul Metropolitan Government Seoul National University Boramae Medical Center
city: Seoul
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
Study officials:
affiliation: Seoul National University Hospital
name: Jin-Tae Kim, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Wong SSC, Choi SW, Lee Y, Irwin MG, Cheung CW. The analgesic effects of intraoperative total intravenous anesthesia (TIVA) with propofol versus sevoflurane after colorectal surgery. Medicine (Baltimore). 2018 Aug;97(31):e11615. doi: 10.1097/MD.0000000000011615.