Clinical trial NCT01886326: Eating Peanuts for Health
Official title: Peanut Consumption and Human Weight Management
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Overweight
Hyperlipidemia
Keywords: Obesity
energy balance
variety
nut intake
Lead sponsor: Purdue University
Sponsor class: OTHER
Collaborators: name: United States Agency for International Development (USAID)
First posted: 2013-06-25
Enrollment: 196
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Evidence is accumulating that peanut consumption confers health benefits, such as reduction of cardiovascular disease risk and possibly diabetes risk (Jenkins et al., 2008; Mattes et al., 2008). However, peanuts are a high fat, energy dense food and concerns about weight gain are widespread. Although research indicates that other characteristics of peanuts offset these properties, and that peanuts may be incorporated into diets without posing a threat to weight gain (Mattes et al., 2008), concern remains among policymakers, healthcare providers, and consumers. Furthermore, worry exists that eating salted peanuts may elevate blood pressure and that eating honey-roasted peanuts make elevate blood sugar. These fears create substantial obstacles to increased peanut consumption.

Recommendations to increase peanut consumption may be made, but if they are not followed, there will be no impact on health. Additional knowledge is needed on: (1) the acceptability of peanuts consumed on a chronic basis, (2) the chronic intake of moderate levels of peanuts and body weight, and 3) the effects of peanuts on blood pressure and blood sugar. The proposed research will examine the acceptability of long-term inclusion of a single form versus varied forms of peanuts in the diet. It is expected that responses will be varied among individuals with different personality characteristics (e.g., prefer sweet versus savory foods, hedonic versus non-hedonic eaters). A better understanding of how different segments of the population choose to include peanuts in their diet and how to optimize long-term consumption should provide insights for better marketing and improved health. Furthermore, it is anticipated that eating salty peanuts will not raise blood pressure and that eating honey-roasted peanuts will not raise blood sugar. Documenting this will add credibility to the evidence that peanuts do not cause weight gain, as well as reinforce recommendations to increase peanut consumption for their health benefits.


Eligibility criteria: Inclusion Criteria:

* Between 18 and 50 years of age
* Weight stable (\< 3 kg weight change within last 3 months)
* Constant habitual activity patterns (no deviation \> 1x/wk at 30 min/session within last 3 months)
* Constant habitual diet patterns within last 3 months
* Willingness to eat all test foods (peanuts daily for 12 weeks)
* No allergy to foods provided in the study (peanuts)
* Not a daily peanut or tree nut consumer
* Not planning to change use of medications known to influence appetite or metabolism
* Not diabetic or hypertensive
* No history of gastrointestinal pathology
* Non-smoker for one year or more

Exclusion Criteria:

-

Primary outcomes:
measure: Change in Weight
timeFrame: 2, 4, 6, 8, 10, and 12 weeks
measure: Change in Blood Lipids
timeFrame: 4, 8, and 12 weeks
measure: Change in Blood Pressure
timeFrame: 2, 4, 6, 8, 10, and 12 weeks
measure: Change in Hedonics of peanut consumption
timeFrame: 12 weeks
measure: Change in Body Composition
timeFrame: 2, 4, 6, 8, 10, and 12 weeks
measure: Change in Fasting Blood Glucose
timeFrame: 4, 8, and 12 weeks
measure: Change in Cortisol
timeFrame: 4, 8, and 12 weeks
measure: Change in Insulin
timeFrame: 4, 8, and 12 weeks
measure: Change in Pulse
timeFrame: 2, 4, 6, 8, 10, and 12 weeks
Secondary outcomes:
measure: Personality Questionnaires
timeFrame: At baseline visit
measure: Flavor attribute liking measures
timeFrame: At baseline
measure: Compliance
timeFrame: 12 weeks
measure: Appetitive Ratings
timeFrame: 4, 8, and 12 weeks
measure: Consumption Parameters
timeFrame: 12 weeks
Other outcomes:
Locations:
city: West Lafayette
country: United States
facility: Purdue University
state: Indiana
Study officials:
affiliation: Purdue University
name: Richard D Mattes, RD, MPH, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Jones JB, Provost M, Keaver L, Breen C, Ludy MJ, Mattes RD. Effects of daily consumption of one or varied peanut flavors on acceptance and intake. Appetite. 2014 Nov;82:208-12. doi: 10.1016/j.appet.2014.07.023. Epub 2014 Jul 23.
citation: Jones JB, Provost M, Keaver L, Breen C, Ludy MJ, Mattes RD. A randomized trial on the effects of flavorings on the health benefits of daily peanut consumption. Am J Clin Nutr. 2014 Mar;99(3):490-6. doi: 10.3945/ajcn.113.069401. Epub 2013 Dec 18.