louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01425762: Influence of Patient Choice of Intrathecal Morphine on Post-cesarean Delivery Pain.
Official title: Influence of Patient Choice of Intrathecal Morphine on Post-cesarean Delivery Pain.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2011-08-30
Enrollment: 120
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a randomized controlled study that will place patients into a "choice" and a "no choice" group. The choice group will be able to choose between receiving 100 mcg or 200 mcg intrathecal morphine. The no choice group will be randomized to receive either 100 mcg or 200 mcg of intrathecal morphine. Following casarean delivery, pain scores will be measured at 3, 6, 12, 24, and 36 hours.

Detailed description: This randomised controlled study will include pre-operative screening with a 2 simple questionnaires and the patient will be randomised into a "choice" and "no choice" groups.

The group with the choice will be offered 2 different doses of intrathecal morphine (100, 200 mcg) which they can decide on after being given a standard script explaining advantages and disadvantages of each dose. Following cesarean section patients will be followed up at 3, 6, 12, 24, 36, 48 hours following spinal injection to assess severity of pain, time to first analgesia, total analgesia requirements, treatment of nausea, vomiting and pruritus.

Eligibility criteria: Inclusion Criteria:

* Women age 18-50 with singleton, term gestation fetuses and scheduled for their 1st, 2nd, or 3rd elective CS (not in labor) will be included.

Exclusion Criteria:

* Patient refusal.

Primary outcomes:
measure: pain scores (0-10) and analgesic use (morphine mg-equivalents) between the groups that have analgesic choice vs. no choice and among the actual doses received.
timeFrame: up to 6 months
Secondary outcomes:
measure: preoperative questionnaire predictor scores versus postoperative pain and analgesic consumption post cesarean delivery.
timeFrame: Baseline and day 1
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University School of Medicine
state: California
Study officials:
affiliation: Stanford University
name: Brendan Carvalho
role: PRINCIPAL_INVESTIGATOR
References:
citation: Carvalho B, Mirza F, Flood P. Patient choice compared with no choice of intrathecal morphine dose for caesarean analgesia: a randomized clinical trial. Br J Anaesth. 2017 May 1;118(5):762-771. doi: 10.1093/bja/aex039.
Clinical trial NCT00081562: Genetics of Ankylosing Spondylitis
Official title: Family Studies of the Genetics of Ankylosing Spondylitis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Spondylitis
Ankylosing Spondylitis
Lead sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Sponsor class: NIH
First posted: 2004-04-19
Enrollment: 1600
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes

Brief summary: Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the joints between the vertebrae of the spine and the joints between the spine and the pelvis. The purpose of this study is to collect information and blood samples from patients with AS and their relatives for use in genetic studies.

Detailed description: AS is a chronic inflammatory disease that eventually causes the affected vertebrae to fuse or grow together. The cause of AS is unknown, but genetic factors seem to play a role. Risk factors include a family history of ankylosing spondylitis and male gender.

This study will collect patient information and blood samples from affected patients (and when available, both parents of the affected patients) of 400 families with children fulfillling the modified New York criteria for AS. Diagnosis of AS will be verified by patient questionnaire, medical record review, and pelvic radiographs. Information from these patients will be used to search the human genome for disease-associated loci and/or genes. This study will also utilize contributions of investigators who have conducted recent clinical or genetic research in AS at 10 academic medical centers throughout North America (the North American Spondylitis Consortium, or NASC).

Eligibility criteria: Inclusion Criteria:

* Meet modified New York criteria for ankylosing spondylitis (AS)
* AS as confirmed by X-rays of sacroiliac joints (between the pelvis and spine)
* At least two siblings in family with AS
* Parents of the participants with AS have the option of also being enrolled

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: Cedars-Sinai Medical Center
state: California
city: Houston
country: United States
facility: University of Texas - Health Science Center at Houston
state: Texas
Study officials:
affiliation: The University of Texas Health Science Center, Houston
name: John D. Reveille, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Brown MA, Wordsworth BP, Reveille JD. Genetics of ankylosing spondylitis. Clin Exp Rheumatol. 2002 Nov-Dec;20(6 Suppl 28):S43-9.
citation: Tsui FW, Tsui HW, Cheng EY, Stone M, Payne U, Reveille JD, Shulman MJ, Paterson AD, Inman RD. Novel genetic markers in the 5'-flanking region of ANKH are associated with ankylosing spondylitis. Arthritis Rheum. 2003 Mar;48(3):791-7. doi: 10.1002/art.10844.
citation: Reveille JD. The genetic basis of spondyloarthritis. Curr Rheumatol Rep. 2004 Apr;6(2):117-25. doi: 10.1007/s11926-004-0056-6.
Clinical trial NCT05254262: Multicenter National Trial of Clinical Results of Surgical Elderly Patients
Official title: An Observational Multicenter National Trial of Clinical Results and Morbimortality of Surgical Elderly Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Surgery--Complications
Age Problem
Lead sponsor: Germans Trias i Pujol Hospital
Sponsor class: OTHER
First posted: 2022-02-24
Enrollment: 2000
Sex: ALL
Minimum age (years): 70
Maximum age (years): 100
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Elderly patients with and age of 70 years old or older

Brief summary: The aim of this study is to study clinical results including mrobidity and mortality of elderly patients (age \> 75 years) in Spain during a 3-month period.

Detailed description: The aim of the study it is to analyze the morbidity and mortality of patients older tha 70 admitted on hospital and who needs surgical operation. The results will be analysed in relationship with surgical risk calculator in order to know if it would be posssible to predict morbi-mortality of these cohort of patirents.

Eligibility criteria: Inclusion Criteria:

* Patients with an age of 70 years old or older
* Admitted on hospital (minimum 1 day of hospital length)
* Needing surgery

Exclusion Criteria:

* Day case -surgery

Primary outcomes:
measure: Mortality
timeFrame: 30 day
measure: Complications
timeFrame: 30 day
Secondary outcomes:
measure: ASA score
timeFrame: preoperative
measure: ACS NSQIP surgical risk score
timeFrame: preoperative
Other outcomes:
Locations:
city: Murcia
country: Spain
facility: Universidad de Murcia
Study officials:
affiliation: Department of Surgery, Hospital Germans Trias i Pujol
name: David Parés, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06777862: Chronic Non-Specific Neck Pain and Quality of Life
Official title: Investigation of Factors Affecting Quality of Life in Chronic Non-Specific Neck Pain
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Neck Pain
Quality of Life
Keywords: chronic neck pain
quality of life
depression
proprioception
muscle strength
Lead sponsor: Kirsehir Ahi Evran Universitesi
Sponsor class: OTHER
First posted: 2025-01-16
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The sample of this study consists of individuals who applied to the Kırşehir Ahi Evran University Physical Medicine and Rehabilitation Polyclinic in Kırşehir province with complaints of neck pain and were diagnosed with chronic non-specific neck pain by specialist physicians.

Brief summary: The factors affecting the quality of life in individuals with chronic non-specific neck pain are not fully known in the studies conducted to date. The aim of this study was to examine the factors affecting the quality of life of individuals with chronic non-specific neck pain.


Eligibility criteria: Inclusion Criteria:

No history of radicular pain, trauma or surgery in the cervical region,

* Between the ages of 18-65,
* Having neck pain for at least 6 months,
* Not having received any treatment for neck pain in the last year
* Volunteers with chronic non-specific neck pain

Exclusion Criteria:

* Those with any systemic disease
* Those with cervical pathology
* Previous surgery in the neck region
* Those with neuromuscular disease
* Those with rheumatology disease
* Infection

Primary outcomes:
measure: Pain Level
timeFrame: 6 weeks
Secondary outcomes:
measure: RANGE OF MOTION
timeFrame: 6 weeks
measure: MUSCLE STRENGTH
timeFrame: 6 weeks
measure: Cervical Region Proprioception Sense
timeFrame: 6 weeks
measure: Depression symptoms
timeFrame: 6 weeks
measure: Quality of Life Level
timeFrame: 6 weeks
measure: Sleep Quality
timeFrame: 6 weeks
measure: Neck Disability Level
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Kırşehir
country: Turkey
facility: Kirsehir Ahi Evran University
state: Merkez
Study officials:
References:
Clinical trial NCT00370591: Study Of Airway Physiology In Adults. SERETIDE DISKUS® Inhaler and FLIXOTIDE® Inhaler Are Trademarks of GSK Croup of Companies.
Official title: Randomised, Double Blind, Parallel Group Study to Assess the Bronchodilative and Bronchoprotective Properties of SERETIDE DISKUS® Inhaler 50/100 mcg Twice Daily vs FLIXOTIDE® Inhaler 200 mcg Twice Daily
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Asthma
Keywords: Inhaled corticosteroids
Asthma
Lead sponsor: GlaxoSmithKline
Sponsor class: INDUSTRY
First posted: 2006-08-31
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Comparison of two asthma treatments by lung function measures.

Detailed description: Single centre, randomised, double-blind, comparator study to demonstrate superiority of salmeterol/fluticasone propionate combination product 50/100mcg bd over fluticasone propionate 100mcg bd with respect to improvements in airway physiology (sRAW) in adults with persistent asthma treated for 4 weeks.

Eligibility criteria: Inclusion:

* Physician documented diagnosis of asthma which has been present for at least 6 months.
* Receiving a total daily dose of 200-500mcg/day beclomethasone dipropionate or equivalent for at least 4 weeks prior to the start of the run-in period.

Exclusion:

* Has had 3 or more courses of oral corticosteroids in the 12 months previous to visit 1

Primary outcomes:
measure: Specific airway resistance (sRAW kPa.L.s) measured before the study medication dose at the end of treatment (week 4)
Secondary outcomes:
measure: sRAW measured post-dose at Week 2 and week 4. % symptom-free days over Weeks 1-4. % symptom-free nights over Weeks 1-4. Type and frequency of adverse events.
Other outcomes:
Locations:
city: Manchester
country: United Kingdom
facility: GSK Investigational Site
state: Lancashire
Study officials:
affiliation: GlaxoSmithKline
name: GSK Clinical Trials
role: STUDY_DIRECTOR
References:
citation: This study has not been published in the scientific literature.
citation: Houghton CM, Lawson N, Borrill ZL, Wixon CL, Yoxall S, Langley SJ, Woodcock A, Singh D. Comparison of the effects of salmeterol/fluticasone propionate with fluticasone propionate on airway physiology in adults with mild persistent asthma. Respir Res. 2007 Jul 14;8(1):52. doi: 10.1186/1465-9921-8-52.
Clinical trial NCT05677191: PFNA vs Dual Mobility in Treatment of Unstable Trochanteric Fractures
Official title: The Usage Of Proximal Femoral Nail Versus Dual Mobility Arthroplasty In Treatment Of Unstable Trochanteric Fractures
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Trochanteric Fractures
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-01-10
Enrollment: 40
Sex: ALL
Minimum age (years): 60
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Proximal femoral nail \[PFNA\] versus dual mobility arthroplasty in treatment of unstable trochanteric fractures

Detailed description: compare clinial outcome between two different procdures either using pfna or arthroplasty in the treatment of unstable trochaneric fractures

Eligibility criteria: Inclusion Criteria:

* patients with trochanteric unstable fractures.
* age 60 or above
* recent fracture time within 2 weeks time period
* trochanteric starting point in pfna
* patients medical condition is stable

Exclusion Criteria:

* stable trochanteric fractures
* delayed or neglected fractures
* unstable patients medical conditions
* pirformis fossa starting point in pfna

Primary outcomes:
measure: Hip score
timeFrame: Through study completion, an average of 1 year"
measure: Operation time
timeFrame: During surgery
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04147091: Nano-hydroxyapatite and Ozone - Effect on Approximal Initial Caries
Official title: Influence of Nano-hydroxyapatite and Ozone on Approximal Initial Caries
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Caries,Dental
Lead sponsor: Pomeranian Medical University Szczecin
Sponsor class: OTHER
First posted: 2019-10-31
Enrollment: 92
Sex: ALL
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Objectives: to assess the efficiency of three methods of enamel remineralization on initial approximal caries: 1. a nano-hydroxyapatite gel, 2. gaseous ozone therapy 3. combination of a nano-hydroxyapatite gel and ozone.

Materials and Methods: Patients (n=92, age 20-30y) with initial approximal enamel lesions on premolar and molar teeth (n=546) randomly allocated to three groups subjected to a 6-months treatment: Group I: domestic nano-hydroxyapatite remineralizing gel, group II: in-office ozone therapy, group III: both remineralizing gel and ozone therapy. Caries lesions assessed on bitewing radiographs at baseline, after 1 year and after 2 years.


Eligibility criteria: Inclusion Criteria:

-initial approximal enamel lesions on premolar and molar teeth

Exclusion Criteria:

* distal surface of the last tooth in arch, overlapping teeth
* fillings on approximal surfaces of teeth of interest
* ongoing orthodontic therapy with braces or other appliances

Primary outcomes:
measure: Remineralizing effect
timeFrame: baseline
Secondary outcomes:
measure: Remineralizing effect - follow-up
timeFrame: after 1 year and after 2 years
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03640091: Pre-extractive Inter-radicular Implant Bed Preparation Versus Conventional Post-extractive Inter-radicular Implant Bed Preparation in Mandibular Molars
Official title: Implant in Mandibular Molars
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Randomized Clinical Trial
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2018-08-21
Enrollment: 2
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Pre-extractive Inter-radicular Implant Bed Preparation versus Conventional Post-extractive Inter-radicular Implant Bed Preparation in Mandibular Molars


Eligibility criteria: Inclusion Criteria:

* Patients with badly decayed posterior molar teeth.
* Distance from height of inter-radicular furcation of mandibular molars to the mandibular canal should be equal to or more than 10 mm

Exclusion Criteria:

* Distance from height of inter-radicular furcation of mandibular molars to the mandibular canal equal to or less than 8 mm.
* Heavy smokers more than 20 cigarettes per day.

Primary outcomes:
measure: Implant stability
timeFrame: 1 year
Secondary outcomes:
measure: Marginal bone loss
timeFrame: 1 year
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo University
Study officials:
References:
Clinical trial NCT06812091: Human Microbiome Research and Development for Overcoming Pediatric Diseases
Official title: Prediction and Treatment of Pediatric Diseases and Long-term Outcomes Through Microbiome and Multi-Omics Study by Life Cycle
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Human Microbiome
Pediatrics
Disease
Growth & Development
Lead sponsor: Hanyang University
Sponsor class: OTHER
First posted: 2025-02-06
Enrollment: 500
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Control group: healthy infants without any diagnosed diseases, born full-term, exhibiting normal growth and development.

Case group: infants with diagnosed diseases, including those born prematurely, those with a history of neonatal intensive care unit (NICU) admission, and those exhibiting neurodevelopmental impairments.

Brief summary: Prediction and treatment of pediatric diseases and long-term outcomes through microbiome and multi-omics analysis by life cycle: We aim to demonstrate that a wide range of diseases are associated with gut microbiome dysbiosis and to investigate the subsequent recovery (restoration) or further deterioration of the gut microbiome over time. This study seeks to offer a novel perspective on changes in the gut microbiome, particularly in the context of the gut-lung and gut-brain axes.

Detailed description: Fecal samples are collected and analyzed from birth through childhood, including those from both preterm and term infants. Based on these collected samples, groups are categorized into disease groups commonly observed in children. Genomic DNA is extracted from the fecal samples, followed by high-throughput 16S rRNA amplicon sequencing to analyze the microbial composition. Additionally, multiomics analyses, including metabolomics, are conducted to provide a comprehensive understanding of gut microbiome dynamics. The impact on the microbiome is further investigated in vitro using a fermenter-based intestinal microbiota model system.

Eligibility criteria: Inclusion Criteria:

* children (including newborns) who have obtained their consent from their guardians

Exclusion Criteria:

* subjects who did not obtain consent

Primary outcomes:
measure: Follow-up of growth percentile in height, weight, and head circumference
timeFrame: 2 months old, 4 months old, 6 months old, 1 year old, and then every year until the age of ten years
measure: Obervation of age-specific developmental milestones
timeFrame: 4 months old, 1 year old, 3 years old, school age
measure: Observations on the incidence and frequency of enteritis, sepsis, and respiratory diseases
timeFrame: 2 months old, 4 months old, 6 months old, 1 year old, and then every year until the age of ten years
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Hanyang University Medical Center
Study officials:
affiliation: Hanyang University
name: Hyun-Kyung Park, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00421291: Effect of Information on Service Delivery in Rural India
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Delivery of Services to Rural Populations in India
Lead sponsor: Johns Hopkins University
Sponsor class: OTHER
Collaborators: name: World Bank
name: Sahbhagi Shikshan Kendra
First posted: 2007-01-11
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: A lack of public awareness about entitled health and social services may contribute to poor delivery of services in developing countries. We sought to determine the impact of educating villagers about entitled services.

Detailed description: 105 gram panchayats (village clusters) were randomized to receive information about their guaranteed health, education, and village governance rights. We then selected households within each treatment and control village to assess whether the information had made an impact.

Eligibility criteria: Inclusion Criteria:

* Gram panchayats in Uttar Pradesh

Primary outcomes:
measure: visits by nurse midwife
measure: prenatal exams, tetanus vaccinations, & iron tablets received by pregnant women
measure: infant vaccinations
measure: educational scholarships and fees for children
measure: occurrence of village council meetings
measure: development work in villages
Secondary outcomes:
Other outcomes:
Locations:
city: Multiple Villages
country: India
facility: No facility, this is a community based trial
state: Uttar Pradesh
Study officials:
affiliation: World Bank
name: Priyanka Pandey, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Pandey P, Sehgal AR, Riboud M, Levine D, Goyal M. Informing resource-poor populations and the delivery of entitled health and social services in rural India: a cluster randomized controlled trial. JAMA. 2007 Oct 24;298(16):1867-75. doi: 10.1001/jama.298.16.1867.