Clinical trial NCT06900894: Effects of Platelet-Rich Fibrin and Kinesio Taping on Postoperative Recovery in Oral Surgery
Official title: Effectiveness of Platelet-Rich Fibrin and Elastic Bandaging on Postoperative Pain, Edema, and Recovery Following Impacted Molar Surgery: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Impacted Third Molar Tooth
Postoperative Pain
Postoperative Edema
Keywords: Impacted third molar
elastic bandage
platelet-rich fibrin
postoperative pain
quality of life
Postoperative Edema
Lead sponsor: Mustafa Kemal University
Sponsor class: OTHER
First posted: 2025-03-28
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This study follows a parallel assignment model in which participants are randomly allocated into three groups: Platelet-Rich Fibrin (PRF), Kinesio Taping, and Control. Each group receives a distinct intervention to evaluate the effectiveness of these non-pharmacological approaches in managing postoperative pain, edema, and recovery following impacted third molar surgery.
Primary purpose: TREATMENT

Brief summary: This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in reducing postoperative pain, edema, and improving recovery following impacted third molar surgery. A prospective, randomized clinical trial was conducted with 44 patients aged 18-35 years. Patients were assigned to three groups: (1) PRF applied locally to the extraction socket, (2) Kinesio Taping applied postoperatively and removed on the third day, and (3) a control group receiving standard postoperative care. Postoperative outcomes were assessed on days 3 and 7, including pain levels, edema, and quality of life. This study aims to evaluate PRF and Kinesio Taping as non-pharmacological adjuncts in oral and maxillofacial surgery.

Detailed description: This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in postoperative management following impacted mandibular third molar surgery. Postoperative complications, such as pain and edema, are commonly observed and may impact patient comfort and recovery. This study aims to evaluate the feasibility of two non-pharmacological approaches-PRF and Kinesio Taping (Elastic Bandaging)-in postoperative care.

A total of 44 patients aged 18-35 years participated in this prospective, randomized clinical trial. Patients were assigned to one of three groups:

PRF Group: Platelet-rich fibrin (PRF) was applied locally into the extraction socket.

Kinesio Taping Group: An elastic bandage was applied postoperatively to the surgical area and removed on the third day.

Control Group: Standard postoperative care was provided with no additional intervention.

Postoperative evaluations were conducted on the 3rd and 7th days. The measured parameters included:

Edema: Measured using anthropometric techniques.

Pain: Assessed with the Numerical Rating Scale (NRS).

Quality of Life: Evaluated using the Oral Health Impact Profile-14 (OHIP-14).

This study aims to assess the feasibility of PRF and Kinesio Taping in postoperative management.

Eligibility criteria: Inclusion Criteria:

* Ages 18-35 years
* Systemically healthy individuals
* Non-smokers
* No psychological disorders
* Preoperative pain level between 0-3 on the Numerical Rating Scale (NRS)
* No preoperative edema in the surgical area
* Impacted mandibular third molars classified as Class 1 or 2, Level B, and mesioangular according to the Pell-Gregory classification
* Signed an informed consent form

Exclusion Criteria:

* Under 18 or over 35 years old
* Presence of chronic or systemic diseases
* Pregnant or breastfeeding patients
* Surgical duration exceeding 45 minutes
* Smokers
* Patients requiring prophylactic antibiotics due to systemic health conditions
* Patients who did not meet the study criteria or did not sign the informed consent form

Primary outcomes:
measure: Postoperative Pain Assessment (NRS)
timeFrame: Preoperative day 1, postoperative days 3 and 7
measure: Postoperative Facial Swelling Assessment
timeFrame: Preoperative day 1, postoperative days 3 and 7
measure: Oral Health Impact Profile-14 (OHIP-14) Score
timeFrame: Postoperative days 3 and 7
Secondary outcomes:
Other outcomes:
Locations:
city: Hatay
country: Turkey
facility: Hatay Mustafa Kemal University, Faculty of Dentistry
Study officials:
affiliation: Mustafa Kemal University
name: züleyha başar karakuzu, DDS
role: PRINCIPAL_INVESTIGATOR
References: