louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05141565: The Kunshan Elderly Health Study
Official title: The Kunshan Elderly Health Study - a Community-based Prospective Cohort Study of Chronic Disease, Mortality and Associated Factors Among Elderly Chinese
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases
Diabetes Mellitus
Cancer
Cognitive Impairment
Sarcopenia
Frailty
Depression
Keywords: Nutrition
Lifestyle
Cohort
Elderly
Lead sponsor: Soochow University
Sponsor class: OTHER
Collaborators: name: Kunshan Center for Disease Control and Prevention
name: Suzhou Center for Disease Control and Prevention
First posted: 2021-12-02
Enrollment: 5945
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Approximately 8,000 elderly residents (both men and women) aged 65 years and above in communities in Kunshan, Eastern China.

Brief summary: The Kunshan Elderly Health Study (KEHS) is a community-based prospective cohort study of chronic disease, mortality and associated factors among elderly adults in Kunshan, Eastern China.

Detailed description: The Kunshan Elderly Health Study (KEHS) is a project organized by the Soochow University, in collaboration with the Kunshan \& Suzhou Centers for Disease Control and Prevention. It was primarily designed to assess risk factors (nutritional, metabolic, lifestyle, etc.) for chronic diseases and mortality among community residents aged 65 years and above, and explore effective intervention measures, so as to ultimately reduce the burden of disease and promote healthy aging. In addition, findings of this study would contribute to further understanding of pathogenesis of the chronic diseases and provide new ideas for precise prevention, drug development and risk prediction.

Eligibility criteria: Inclusion Criteria:

* Locally registered-residents in Kunshan
* Aged 65 years or above
* Voluntary agreement to participate in the study (with written informed consent)

Exclusion Criteria:

* Patients with stroke, coronary heart disease or cancer
* Patients with severe physical or mental illness
* People unable to complete the survey

Primary outcomes:
measure: Incidence of chronic diseases
timeFrame: Trough study completion, an average of 10 years
measure: Mortality
timeFrame: Trough study completion, an average of 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Kunshan
country: China
facility: Kunshan Center for Disease Control and Prevention
state: Jiangsu
Study officials:
affiliation: Soochow University
name: Hui Zuo, M.D., Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04332965: Periostin and Non-Surgical Periodontal Treatment
Official title: The Effect of Non-Surgical Periodontal Treatment on Gingival Crevicular Fluid Periostin Levels in Patients With Gingivitis and Chronic Periodontitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Periodontal Diseases
Keywords: Chronic periodontitis
Gingival crevicular fluid
Gingivitis
Non-surgical periodontal treatment
Periostin
Lead sponsor: Kırıkkale University
Sponsor class: OTHER
First posted: 2020-04-03
Enrollment: 90
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment. Gingival crevicular fluid periostin levels were assessed at baseline, at the 6th week and the 3rd month after treatment.

Detailed description: Periostin is commonly found in collagen-rich tissues, which is thought to affect the production of collagen fibers. Additionally, periostin is synthesized in tissues exposed to constant mechanical forces such as the periosteum, periodontal ligament, tendon, heart valve and skin. Periostin mediates inflammation and fibrosis during diseases of various organs, including the heart, lung, kidney, skin, liver, skeletal muscle and retina.

This study evaluated periostin levels in gingival crevicular fluid from patients with chronic periodontitis, gingivitis and periodontally healthy as well as the effect of non-surgical periodontal treatment on gingival crevicular fluid periostin levels.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of chronic periodontitis
* Clinical diagnosis of gingivitis
* Clinical diagnosis of periodontal health

Exclusion Criteria:

* have any systemic disease
* to be alcohol consumer
* to receive any periodontal therapy in the past 6 months
* to take any drugs regularly
* to be pregnant and/or lactate

Primary outcomes:
measure: Change in periostin
timeFrame: Baseline, 6th week and 3rd month
Secondary outcomes:
measure: Change in periodontal clinical parameter
timeFrame: Baseline, 6th week and 3rd month
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03945565: FiO2 and Outcomes After OPCAB (the CARROT Trial)
Official title: Effect of Intraoperative Oxygen Tension on Patient Outcomes After Off-pump Coronary Artery Bypass Grafting (the CARROT Trial)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Coronary Artery Disease
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: Asan Medical Center
name: Severance Hospital
First posted: 2019-05-10
Enrollment: 414
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Conventionally, a relatively high level of fraction of inspired oxygen (FiO2) has been used for secure a margin of safety in patients undergoing cardiac surgery including off-pump coronary artery bypass grafting (OPCAB). Since the potential adverse effects of hyperoxemia (via reactive oxygen species, vasocontriction, perfusion heterogeneity, myocardiac injury, etc.), various studies on this topic has been performed. However, the results are conflicting and inconsistent, and the consensus about whether the use of additional oxygen supply in cardiac surgery has not been reached among practitioners yet. This study is a multicenter study (Seoul National University, Asan Medical Center, Severance Hospital) where the effect of different level of FiO2 on postoperative clinical outcomes is evaluated.

Detailed description: A sub-study will also be conducted in part of patients of the present study. In 40 out of 500 (expected) patients, two different levels of FiO2 will be sequentially set with a 5-minute interval after the induction of general anesthesia. Mixed venous and regional cerebral oxygen saturation will then be recorded according to the change of FiO2.

Eligibility criteria: Inclusion Criteria:

* All patients scheduled for elective off-pump coronary artery bypass grafting

Exclusion Criteria:

* emergency
* robot-assisted surgery
* minimally invasive cardiac surgery requiring thoracotomy/one-lung anesthesia
* preoperative pulmonary morbidity requiring oxygen therapy
* preoperative use of ECMO or IABP
* preoperative tracheal intubation or mechanical ventilation

Primary outcomes:
measure: hospital LOS
timeFrame: From the beginning of surgery until the hospital discharge after surgery through study completion, an expected average of two weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Department of Anesthesiology and Pain Medicine, Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: Yunseok Jeon
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00911365: Trial of Autologous Mesenchymal Stem Cells in Patients With Multiple System Atrophy
Official title: A Double-blind Placebo-controlled Randomized Clinical Trial of Autologous Mesenchymal Stem Cells in Patients With Multiple System Atrophy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Multiple System Atrophy
Keywords: voluntary participants
75 years old or less
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2009-06-01
Enrollment: 27
Sex: ALL
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is based on positive results in open label trial of mesenchymal stem cells therapy in patients with Multiple System Atrophy (MSA).


Eligibility criteria: Inclusion Criteria:

* 75 Years Old or Less
* Multiple System Atrophy
* Voluntary Participants

Exclusion Criteria:

* Doubted dementia (MMSE \< 24)
* Severe febrile condition
* Serum SGOT/SGPT three times above
* Malignant mass

Primary outcomes:
measure: Scores on unified MSA rating scale
timeFrame: one month
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
Study officials:
References:
Clinical trial NCT00694265: Sonographic Follow-up of Patients With Carpal Tunnel Syndrome Undergoing Surgical or Conservative Treatment
Official title: Sonographic Follow-up of Patients With Carpal Tunnel Syndrome Undergoing Surgical or Conservative Treatment: Prospective Cohort Study.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Keywords: Carpal Tunnel Syndrome
Median Nerve
Ultrasonography
Prospective cohort study
Lead sponsor: University of Bern
Sponsor class: OTHER
First posted: 2008-06-10
Enrollment: 55
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with suspected CTS

Brief summary: In wrists with carpal tunnel syndrome (CTS) the sonographically measured largest cross-sectional area (CSA) of the median nerve is increased. We compared the changes in largest CSA in wrists undergoing surgical decompression and wrists undergoing conservative treatment of CTS.

Detailed description: Objective:

In wrists with carpal tunnel syndrome (CTS) the sonographically measured largest cross-sectional area (CSA) of the median nerve is increased. We compared the changes in largest CSA in wrists undergoing surgical decompression and wrists undergoing conservative treatment of CTS.

Methods:

Prospective cohort study in 55 consecutive patients with 78 wrists with established CTS, including 60 wrists with surgical decompression and 18 wrists with conservative treatment. A sonographic examination was scheduled before and at 4 months after initiation of treatment. Changes in CSA between wrists with surgical and wrists with conservative treatment were compared using linear regression models.

Eligibility criteria: Inclusion Criteria:

* wrists with established CTS

Exclusion Criteria:

* prior surgery for CTS
* traumatic lesions
* coexistent neurological disease

Primary outcomes:
measure: Measure of the largest cross-sectional area (CSA) of the median nerve
timeFrame: Before and 4 months after initiation of treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Bern
country: Switzerland
facility: Dep. of Plastic and Hand Surgery, Bern University Hospital
Study officials:
affiliation: Institute of Social and Preventive Medicine, University of Bern, Switzerland
name: Peter Jüni, MD
role: STUDY_DIRECTOR
affiliation: Dep. of Rheumatology, Immunology and Allergology, Bern University Hospital, Switzerland
name: Hans-Rudolf Ziswiler, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ziswiler HR, Reichenbach S, Vogelin E, Bachmann LM, Villiger PM, Juni P. Diagnostic value of sonography in patients with suspected carpal tunnel syndrome: a prospective study. Arthritis Rheum. 2005 Jan;52(1):304-11. doi: 10.1002/art.20723.
citation: Bachmann LM, Juni P, Reichenbach S, Ziswiler HR, Kessels AG, Vogelin E. Consequences of different diagnostic "gold standards" in test accuracy research: Carpal Tunnel Syndrome as an example. Int J Epidemiol. 2005 Aug;34(4):953-5. doi: 10.1093/ije/dyi105. Epub 2005 May 23.
Clinical trial NCT03230565: Continuous Infusions Vs Scheduled Bolus Infusions
Official title: A Prospective Comparison of Pain and Analgesia in Patients with Continuous Peripheral Nerve Block Catheters Using Continuous Infusion or Scheduled Bolus Infusion
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE4
Conditions: Surgical Procedure, Unspecified
Pain, Postoperative
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2017-07-26
Enrollment: 240
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Comparison of two groups: 1) Continuous infusion group 2) Bolus Infusion group
Primary purpose: TREATMENT

Brief summary: To compare continuous infusions to bolus infusions and there affect on post-surgical pain.

Detailed description: Regional anesthetic techniques are an integral part to many anesthetic approaches, providing both intraoperative and postoperative anesthesia and analgesia. Regional anesthesia peripheral nerve blocks have been shown to reduce postoperative pain and improve measures such as opioid requirements and readiness for discharge. By using a catheter technique for continuous peripheral nerve blocks, analgesia can be extended well into post-operative days 2 and 3, further extending these benefits. Historically these catheters have implemented a continuous dosing regimen of local anesthetic, but increasingly there is evidence of improved analgesic outcomes without adverse effects by using a scheduled bolus dosing regimen. Many institutions have implemented this new protocol for catheter dosing. The beneficial effect of scheduled bolus dosing has not been studied in all blocks and all surgical procedures.

Eligibility criteria: Inclusion Criteria: Enrollment will be offered to adult patients with ASA physical status I, II, or III, presenting for nerve block catheters for post-operative analgesia.

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Exclusion Criteria: Exclusion criteria will include: pregnancy, incarceration, age \<18, BMI \>35, pre-operative opioid use \>30 mg morphine equivalents per day, inability to communicate with investigators by telephone, and pre-existing neuropathy of the operative extremity.

Primary outcomes:
measure: Post-surgical pain
timeFrame: 2-3 days after surgery
Secondary outcomes:
measure: Opioid Consumption
timeFrame: 2-3 days after surgery
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University
state: California
Study officials:
affiliation: Stanford University
name: Jean Louis-Horn, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03347565: Brain Function in Adolescent Eating Disorders and Healthy Peers
Official title: Neurocircuitry of Temperament and Motivated Behavior in Adolescent Eating Disorders
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Eating Disorder
Keywords: adolescents, healthy controls
Lead sponsor: University of California, San Diego
Sponsor class: OTHER
First posted: 2017-11-20
Enrollment: 155
Sex: FEMALE
Minimum age (years): 14
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study is currently enrolling adolescent females between the ages of 14-17 who are right handed and who are either currently ill with an eating disorder or who have never had an eating disorder or any other mental illness

Brief summary: This study of adolescent eating disorders (ED) will examine the association of temperament-based classifications, brain activation during incentive processing, and ED symptoms at time of scan and 1 year later to better understand the neurobiology and symptoms of ED. We will recruit 150 females currently ill with an ED and 50 controls ages 14-17 to investigate how temperaments reflecting greater inhibition, impulsivity, or effortful control correspond to 1) clinical symptoms and 2) the brain's response to anticipation and outcome of salient stimuli, and 3) by collecting follow-up clinical data one year later, identify how temperament-based subtypes predict ED symptom change (e.g., clinical prediction). Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).


Eligibility criteria: Inclusion Criteria:

* Female
* Meet DSM-V criteria for an Eating Disorder or Never met criteria for an Eating disorder
* Medically stable
* Post-Pubertal (must have started menses, but subsequent loss of menses secondary to ED is fine).

Exclusion Criteria:

* Psychotic illness/other mental illness requiring hospitalization
* Current dependence on drugs or alcohol
* Physical conditions known to influence eating or weight (e.g, diabetes mellitus, pregnancy).
* On psychoactive medication
* Organic brain syndromes, delirium, psychotic disorders, or intellectual disability
* Neurological or medical disorders such as seizure disorder
* Any contraindication to undergoing an MRI
* Major depressive disorder
* Left handed

Primary outcomes:
measure: Brain function
timeFrame: 1 year (fMRI Scan)
Secondary outcomes:
Other outcomes:
Locations:
city: San Diego
country: United States
facility: University of California San Diego
state: California
Study officials:
References:
Clinical trial NCT04282265: The Effects of Red Spinach Extract on Physical Performance Following Chronic Resistance Training in Trained Males
Official title: The Effects of Red Spinach Extract on Health on Physical Performance Following Chronic Resistance Training in Trained Males
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sports
Lead sponsor: Lipscomb University
Sponsor class: OTHER
First posted: 2020-02-24
Enrollment: 30
Sex: MALE
Minimum age (years): 18
Maximum age (years): 34
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Red Spinach is a natural food which is a rich source of nitrates, which are beneficial in hemodynamics, cardiovascular function, and have natural hypotensive and antianginal effects . In recent research, Red spinach extract has been shown to be beneficial in acute exercise performance. However, currently it is unclear how these acute increases in performance may translate to long term training adaptations.

This research study is designed to measure the effects of red spinach extract (RSE) on markers of physical performance, body composition, and health following chronic resistance training and anaerobic exercise.

Detailed description: The investigators aim to measure muscle strength, athletic performance, body composition, and muscle size in two groups of adults before and after 11 weeks of intervention in a randomized, double blinded study. One group (n=15 ) will receive an intervention of resistance exercise and a Red Spinach Extract supplement, and the other group (n=15) will receive resistance exercise and a placebo (maltodextrin).

Eligibility criteria: Inclusion Criteria:

* 18-35 years old
* At least 1 year of resistance training experience
* Are free of musculoskeletal injuries
* Are not taking medications that may interfere with study measurements

Exclusion Criteria:

* Participant that cannot take either the RSE or placebo supplement will be excluded, as this will be a double-blind study.
* Furthermore, participants that cannot participate in pre- and post-research testing, and/or those that cannot commit to regular training sessions will be excluded.
* Inability to perform physical exercise (determined by health and activity questionnaire)
* Taking any other nutritional supplement or performance enhancing drug.
* Any chronic illness that causes continuous medical care.

Primary outcomes:
measure: Muscular Strength
timeFrame: 11 weeks
measure: Muscular Hypertrophy
timeFrame: 11 weeks
measure: Body Composition
timeFrame: 11 weeks
measure: Wingate Anaerobic (WnT) Cycle test performance
timeFrame: 11 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Nashville
country: United States
facility: Jeremy Townsend
state: Tennessee
Study officials:
References:
Clinical trial NCT01623765: Lung Cancer Diagnosis and Staging Using Ultrasound Guidance
Official title: Diagnosis and Staging of Lung Cancer Using Minimally Invasive Technique With Ultrasound Guidance
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lung Cancer
Keywords: Endobronchial ultrasound, lung cancer
Lead sponsor: Singapore General Hospital
Sponsor class: OTHER
First posted: 2012-06-20
Enrollment: 680
Sex: ALL
Minimum age (years): 21
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with suspected lung cancer

Brief summary: To collect data of all patients who have undergone Endobronchial ultrasound for diagnosis or staging of suspected lung cancer

Detailed description: Introduction: Endobronchial Ultrasound (EBUS) is a procedure that is performed via flexible bronchoscopy under moderate sedation for visualization of lymph nodes in the chest and biopsy under real-time guidance for the staging of lung cancer or evaluation of enlarged lymph nodes. In addition, lung lesions or masses can be visualized and biopsied in the same sitting. The use of EBUS has enhanced the safety and diagnostic yield of flexible bronchoscopy.

Aim: The data of patients with suspected lung cancer or undiagnosed lymph node enlargement in whom bronchoscopy with EBUS guidance is clinically indicated will be collected prospectively.

Results from EBUS are considered positive if a specific diagnosis is obtained ( eg malignancy) or if lymphocytes are present in the lymph node biopsy, indicating accurate sampling of lymph node. In patients with non-diagnostic EBUS, the results from other procedures will be compared for analysis.

Eligibility criteria: Inclusion Criteria:

* Patients who have undergone endobronchial ultrasound

Exclusion Criteria: None

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: Singapore General Hospital
Study officials:
References: