Clinical trial NCT01874691: China Acute Myocardial Infarction Registry
Official title: China Acute Myocardial Infarction Registry
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Myocardial Infarction
Keywords: acute myocardial infarction
China
Registry
Lead sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital
Sponsor class: OTHER
First posted: 2013-06-11
Enrollment: 20000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Eligible patients admitted within 7 days of acute ischemic symptoms and diagnosed acute ST-elevation or non ST-elevation myocardial infarction.

Brief summary: This study is to build a Chinese national registry and surveillance system for acute myocardial infarction(AMI) to obtain real-world information about current status of characteristics, risk factors, diagnosis, treatment and outcomes of Chinese AMI patients; And to propose scientific precaution strategies aimed to prevent effectively from the incidence of AMI; And to optimize the management and outcomes of AMI patients through implementation of guideline recommendations in clinical practice, and analysis and development of effective treatment strategies; And to create cost-effective assessment system.

Detailed description: The aim of the study is to establish the national platform for surveillance, clinical research and translational medicine in China, designed to facilitate efforts to improve the quality of AMI patient care and thus decrease morbidity and mortality associated with AMI.

Eligibility criteria: Inclusion Criteria:

* Eligible patients must be admitted within 7 days of acute ischemic symptoms and diagnosed acute ST-elevation or non ST-elevation myocardial infarction. Diagnosis criteria must meet Universal Definition for AMI (2012). All participating hospitals are required to enroll consecutive patients with AMI.

Exclusion Criteria:

* Myocardial infarction related to percutaneous coronary intervention and coronary artery bypass grafting.

Primary outcomes:
measure: In-hospital mortality of the patients with acute myocardial infarction in different-level hospitals across China
timeFrame: the duration of hospital stay, an expected average of 2 weeks
Secondary outcomes:
measure: The rate of the application of thrombolysis and primary percutaneous coronary intervention for Chinese patients with acute myocardial infarction in different-level hospitals
timeFrame: 24 hours
measure: provoking factors of Chinese patients with AMI across different areas and different population in China
timeFrame: 24 hours
Other outcomes:
measure: the in-hospital cost of Chinese patients with acute myocardial infarction
timeFrame: the duration of hospital stay, an expected average of 2 weeks
Locations:
city: Beijing
country: China
facility: Fuwai Hospital
state: Beijing
Study officials:
affiliation: Fuwai Hospital, Chinse Academy of Medical Sciences
name: Yuejin Yang, MD.
role: STUDY_CHAIR
References:
citation: Peterson ED, Roe MT, Rumsfeld JS, Shaw RE, Brindis RG, Fonarow GC, Cannon CP. A call to ACTION (acute coronary treatment and intervention outcomes network): a national effort to promote timely clinical feedback and support continuous quality improvement for acute myocardial infarction. Circ Cardiovasc Qual Outcomes. 2009 Sep;2(5):491-9. doi: 10.1161/CIRCOUTCOMES.108.847145.
citation: Cui K, Fu R, Yang J, Xu H, Yin D, Song W, Wang H, Zhu C, Feng L, Wang Z, Wang Q, Lu Y, Dou K, Yang Y. Admission Blood Glucose and 2-Year Mortality After Acute Myocardial Infarction in Patients With Different Glucose Metabolism Status: A Prospective, Nationwide, and Multicenter Registry. Front Endocrinol (Lausanne). 2022 Jun 15;13:898384. doi: 10.3389/fendo.2022.898384. eCollection 2022.
citation: Cui K, Fu R, Yang J, Xu H, Yin D, Song W, Wang H, Zhu C, Feng L, Wang Z, Wang Q, Lu Y, Dou K, Yang Y; CAMI Registry Investigators. Stress hyperglycemia ratio and long-term mortality after acute myocardial infarction in patients with and without diabetes: A prospective, nationwide, and multicentre registry. Diabetes Metab Res Rev. 2022 Oct;38(7):e3562. doi: 10.1002/dmrr.3562. Epub 2022 Jul 13.
citation: Shi W, Ni L, Yang J, Fan X, Yu M, Yang H, Yu M, Yang Y; China Acute Myocardial Infarction (CAMI) Registry study group. The Clinical Impact of Proton Pump Inhibitors When Co-Administered With Dual Antiplatelet Therapy in Patients Having Acute Myocardial Infarction With Low Risk of Gastrointestinal Bleeding: Insights From the China Acute Myocardial Infarction Registry. Front Cardiovasc Med. 2021 Sep 22;8:685072. doi: 10.3389/fcvm.2021.685072. eCollection 2021.
citation: Shi W, Fan X, Yang J, Ni L, Su S, Yu M, Yang H, Yu M, Yang Y; China Acute Myocardial Infarction(CAMI) Registry Study Group. In-hospital gastrointestinal bleeding in patients with acute myocardial infarction: incidence, outcomes and risk factors analysis from China Acute Myocardial Infarction Registry. BMJ Open. 2021 Sep 7;11(9):e044117. doi: 10.1136/bmjopen-2020-044117.
citation: Song CX, Fu R, Yang JG, Xu HY, Gao XJ, Wang CY, Zheng Y, Jia SB, Dou KF, Yang YJ; CAMI Registry study group. Angiographic characteristics and in-hospital mortality among patients with ST-segment elevation myocardial infarction presenting without typical chest pain: an analysis of China Acute Myocardial Infarction registry. Chin Med J (Engl). 2019 Oct 5;132(19):2286-2291. doi: 10.1097/CM9.0000000000000432.
citation: Song C, Fu R, Li S, Yang J, Wang Y, Xu H, Gao X, Liu J, Liu Q, Wang C, Dou K, Yang Y. Simple risk score based on the China Acute Myocardial Infarction registry for predicting in-hospital mortality among patients with non-ST-segment elevation myocardial infarction: results of a prospective observational cohort study. BMJ Open. 2019 Sep 12;9(9):e030772. doi: 10.1136/bmjopen-2019-030772.
citation: Song C, Fu R, Dou K, Yang J, Xu H, Gao X, Wang H, Liu S, Fan X, Yang Y. Association between smoking and in-hospital mortality in patients with acute myocardial infarction: results from a prospective, multicentre, observational study in China. BMJ Open. 2019 Aug 30;9(8):e030252. doi: 10.1136/bmjopen-2019-030252.
citation: Leng W, Yang J, Fan X, Sun Y, Xu H, Gao X, Wang Y, Li W, Xu Y, Han Y, Jia S, Zheng Y, Yang Y; behalf CAMI Registry investigators. Contemporary invasive management and in-hospital outcomes of patients with non-ST-segment elevation myocardial infarction in China: Findings from China Acute Myocardial Infarction (CAMI) Registry. Am Heart J. 2019 Sep;215:1-11. doi: 10.1016/j.ahj.2019.05.015. Epub 2019 Jun 6.
citation: Fu R, Song CX, Dou KF, Yang JG, Xu HY, Gao XJ, Liu QQ, Xu H, Yang YJ. Differences in symptoms and pre-hospital delay among acute myocardial infarction patients according to ST-segment elevation on electrocardiogram: an analysis of China Acute Myocardial Infarction (CAMI) registry. Chin Med J (Engl). 2019 Mar 5;132(5):519-524. doi: 10.1097/CM9.0000000000000122.
citation: Dai Y, Yang J, Gao Z, Xu H, Sun Y, Wu Y, Gao X, Li W, Wang Y, Gao R, Yang Y; CAMI Registry study group. Atrial fibrillation in patients hospitalized with acute myocardial infarction: analysis of the china acute myocardial infarction (CAMI) registry. BMC Cardiovasc Disord. 2017 Jan 4;17(1):2. doi: 10.1186/s12872-016-0442-9.
citation: Sun H, Yang YJ, Xu HY, Yang JG, Gao XJ, Wu Y, Li W, Wang Y, Liu J, Jin C, Song L; CAMI Registry Study Group. [Survey of medical care resources of acute myocardial infarction in different regions and levels of hospitals in China]. Zhonghua Xin Xue Guan Bing Za Zhi. 2016 Jul 24;44(7):565-9. doi: 10.3760/cma.j.issn.0253-3758.2016.07.003. Chinese.