Clinical trial NCT05269004: A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis
Official title: A Multicenter, Single-Arm, Open-Label, Extension, Rollover Study To Evaluate The Long-Term Safety And Efficacy Of Ocrelizumab In Patients With Multiple Sclerosis
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Multiple Sclerosis
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2022-03-07
Enrollment: 1300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a Phase IIIb, single-arm, multicenter, OLE study. Participants receiving ocrelizumab as an investigational medicinal product (IMP) in a Roche sponsored Parent study who continue to receive ocrelizumab or are in safety follow-up at the time of the closure of their respective Parent study (WA21092, WA21093 or WA25046) are eligible for enrollment in this extension study. Participants who will continue ocrelizumab treatment will receive IMP based on the dosage and administration received at the time of rollover from the Parent study.


Eligibility criteria: Inclusion criteria

* Prior eligibility for and previous participation in 1 of the Roche-sponsored Parent Studies WA21092, WA21093, or WA25046 with the participant either receiving ocrelizumab as an investigational medicinal product (IMP) or being in safety follow-up after treatment discontinuation
* For female participants of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use adequate acceptable contraception during the treatment period and for at least 6 months or longer if the local label is more stringent after the final dose of ocrelizumab, as applicable in the ocrelizumab package leaflet

Exclusion criteria

* Concurrent participation in any clinical trial (other than the Parent study)
* Unable or unwilling to comply with the requirements of the protocol

Primary outcomes:
measure: Incidence and severity of adverse events, with severity determined according to the NCI CTCAE v5.0
timeFrame: Up to 44 months
Secondary outcomes:
measure: Change in Expanded Disability Status Scale (EDSS) score over time
timeFrame: Week 0, 24, 48, 72, 96, 120, 168
measure: Change in 9-Hole Peg Test (9HPT) over time
timeFrame: Week 0, 24, 48, 72, 96, 120, 168
measure: Change in Timed 25-Foot Walk Test (T25FWT) over time
timeFrame: Week 0, 24, 48, 72, 96, 120, 168
measure: The number of T1 lesions and number of new or enlarging T2 lesions
timeFrame: Week 0, 24, 48, 72, 96, 120, 168
measure: The change in total volume of T2 lesions and in total non-enhancing T1 lesion volume
timeFrame: Week 0, 24, 48, 72, 96, 120, 168
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Barrow Neurological Institute
state: Arizona
city: Phoenix
country: United States
facility: Arizona Neuroscience Research LLC
state: Arizona
city: Laguna Hills
country: United States
facility: MS Center of California
state: California
city: Palo Alto
country: United States
facility: Stanford Hospital and Clinics
state: California
city: San Francisco
country: United States
facility: University of California San Francisco
state: California
city: San Francisco
country: United States
facility: University of California San Francisco
state: California
city: Aurora
country: United States
facility: University of Colorado - Anschutz Medical Campus (University of Colorado Health Sciences Center)
state: Colorado
city: Fort Collins
country: United States
facility: Advanced Neurosciences Research LLC
state: Colorado
city: Maitland
country: United States
facility: Neurology Associates PA
state: Florida
city: Miami
country: United States
facility: University of Miami
state: Florida
city: Orlando
country: United States
facility: Neurological Services of Orlando
state: Florida
city: Tampa
country: United States
facility: University of South Florida
state: Florida
city: Vero Beach
country: United States
facility: Vero Beach Neurology and Research Institute
state: Florida
city: Atlanta
country: United States
facility: Atlanta Neuroscience Institute
state: Georgia
city: Chicago
country: United States
facility: Northwestern University
state: Illinois
city: Northbrook
country: United States
facility: Consultants in Neurology Ltd
state: Illinois
city: Indianapolis
country: United States
facility: Indiana Univ School of Med
state: Indiana
city: Kansas City
country: United States
facility: Kansas University Medical Center
state: Kansas
city: Boston
country: United States
facility: Massachusetts General Hospital
state: Massachusetts
city: Detroit
country: United States
facility: Wayne State University
state: Michigan
city: Farmington Hills
country: United States
facility: Michigan Institute for Neurological Disorders
state: Michigan
city: West Bloomfield
country: United States
facility: Henry Ford Hospital
state: Michigan
city: Golden Valley
country: United States
facility: Minneapolis Clinic of Neurology
state: Minnesota
city: Minneapolis
country: United States
facility: University of Minnesota
state: Minnesota
city: Saint Louis
country: United States
facility: Washington University
state: Missouri
city: Omaha
country: United States
facility: University of Nebraska Medical Center
state: Nebraska
city: Newark
country: United States
facility: Rutgers New Jersey Medical School Department of Neurology
state: New Jersey
city: Teaneck
country: United States
facility: Holy Name Hospital
state: New Jersey
city: Albuquerque
country: United States
facility: University of New Mexico
state: New Mexico
city: Patchogue
country: United States
facility: South Shore Neurologic Associates PC
state: New York
city: Stony Brook
country: United States
facility: SUNY at Stony Brook
state: New York
city: Charlotte
country: United States
facility: OnSite Clinical Solutions LLC
state: North Carolina
city: Charlotte
country: United States
facility: The Neurological Institute PA
state: North Carolina
city: Charlotte
country: United States
facility: Atrium Health
state: North Carolina
city: Raleigh
country: United States
facility: Raleigh Neurology Associates
state: North Carolina
city: Cincinnati
country: United States
facility: University Neurology Inc.
state: Ohio
city: Westerville
country: United States
facility: Columbus Neuroscience
state: Ohio
city: Oklahoma City
country: United States
facility: Oklahoma Medical Research Foundation
state: Oklahoma
city: Portland
country: United States
facility: Providence Neurological Specialties
state: Oregon
city: Abington
country: United States
facility: Abington Neurological Associates
state: Pennsylvania
city: Providence
country: United States
facility: Rhode Island Hospital
state: Rhode Island
city: Cordova
country: United States
facility: Neurology Clinic PC
state: Tennessee
city: Knoxville
country: United States
facility: Sibyl Wray MD Neurology PC
state: Tennessee
city: Houston
country: United States
facility: Baylor College of Medicine
state: Texas
city: Houston
country: United States
facility: Uni of Texas Health Science Center At Houston
state: Texas
city: Lubbock
country: United States
facility: Bhupesh Dihenia M.D. P.A.
state: Texas
city: San Antonio
country: United States
facility: Neurology Center of San Antonio
state: Texas
city: Burlington
country: United States
facility: University of Vermont Medical Center
state: Vermont
city: Seattle
country: United States
facility: Swedish Neuroscience Institute
state: Washington
city: Tacoma
country: United States
facility: MultiCare Health System Institute for Research and Innovation
state: Washington
city: Ciudad Autonoma Bs As
country: Argentina
facility: Hospital Español
city: Rosario
country: Argentina
facility: Fundacion Rosarina de Neurorehabilitacion
city: St Leonards
country: Australia
facility: Royal North Shore Hospital
state: New South Wales
city: Fitzroy
country: Australia
facility: St Vincent's Hospital Melbourne
state: Victoria
city: Innsbruck
country: Austria
facility: Medizinische Universität Innsbruck
city: Linz
country: Austria
facility: Barmherzige Brueder Konventspital
city: Wien
country: Austria
facility: AKH - Medizinische Universität Wien
city: Grodno
country: Belarus
facility: Grodno University Hospital
state: Brestskaya Voblasts'
city: Vitebsk
country: Belarus
facility: Vitebsk Regional Clinical Hospital
state: Vitsyebskaya Voblasts'
city: Minsk
country: Belarus
facility: State Institution Minsk Research and Practice Center of Surgery Transplantation and Hematology
city: Brugge
country: Belgium
facility: AZ Sint Jan
city: Brussels
country: Belgium
facility: Cliniques Universitaires Saint-Luc
city: Edegem
country: Belgium
facility: UZA
city: Eeklo
country: Belgium
facility: Algemeen Ziekenhuis Alma
city: Roeselare
country: Belgium
facility: AZ Delta Campus Westlaan
city: Goiania
country: Brazil
facility: HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
state: Goiás
city: Porto Alegre
country: Brazil
facility: IMV Pesquisa Neurologica Sociedade Simples Ltda
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Sao Lucas da PUCRS*X
state: Rio Grande Do Sul
city: Joinville
country: Brazil
facility: Clinica Neurológica e Neurocirúrgica de Joinville
state: Santa Catarina
city: Rio de Janeiro
country: Brazil
facility: Hospital Universitario Gaffree e Guinle
city: Rio de Janeiro
country: Brazil
facility: HUCFF-UFRJ - Hospital Universitário Clementino Fraga Filho Universidade Federal do Rio de Janeiro
city: Pleven
country: Bulgaria
facility: MHAT Avis Medica OOD Department of Neurology
city: Sofia
country: Bulgaria
facility: MHATNP Sveti Naum EAD
city: Sofia
country: Bulgaria
facility: University First MHAT-Sofia St. Joan Krastitel EAD
city: Sofia
country: Bulgaria
facility: National Heart Hospital EAD
city: Sofia
country: Bulgaria
facility: Acibadem City Clinic Tokuda Hospital Ead
city: Sofia
country: Bulgaria
facility: Military Medical Academy MHAT Sofia Department of Rheumatology
city: Calgary
country: Canada
facility: Calgary MS Clinic
state: Alberta
city: Edmonton
country: Canada
facility: University of Alberta
state: Alberta
city: Vancouver
country: Canada
facility: UBC Multiple Sclerosis & Neuromyelitis Optica NMO Clinical Trials
state: British Columbia
city: Ottawa
country: Canada
facility: The Ottawa Hospital - General Campus
state: Ontario
city: Toronto
country: Canada
facility: St Michael Hospital
state: Ontario
city: Gatineau
country: Canada
facility: Clinique Neuro Outaouais
state: Quebec
city: Greenfield Park
country: Canada
facility: Recherche Sepmus Inc.
state: Quebec
city: Montreal
country: Canada
facility: Montreal Neurological Institute and Hospital
state: Quebec
city: Varazdin
country: Croatia
facility: General Hospital Varazdin
city: Zagreb
country: Croatia
facility: University Hospital Center Zagreb
city: Brno
country: Czechia
facility: Fakultni nemocnice Brno
city: Brno
country: Czechia
facility: Fakultni nemocnice u sv. Anny v Brne
city: Havirov
country: Czechia
facility: Neurospol s.r.o.
city: Hradec Kralove
country: Czechia
facility: Fakultni nemocnice Hradec Kralove
city: Jihlava
country: Czechia
facility: Nemocnice Jihlava
city: Pardubice
country: Czechia
facility: Pardubicka krajska nemocnice a.s.
city: Praha 2
country: Czechia
facility: Vseobecna fakultni nemocnice v Praze
city: Teplice
country: Czechia
facility: Krajska zdravotni a.s. - Nemocnice Teplice o.z.
city: Tallinn
country: Estonia
facility: West Tallinn Central Hospital
city: Tartu
country: Estonia
facility: Tartu University Hospital
city: Tampere
country: Finland
facility: Tammer Tutka Oy
city: Caen Cedex 9
country: France
facility: CHU CAEN - Hôpital de la Côte de Nacre
state: Calvados
city: Bordeaux
country: France
facility: Groupe Hospitalier Pellegrin
city: Bron
country: France
facility: Hopital Neurologique Pierre Wertheimer
city: Clermont Ferrand Cedex
country: France
facility: CHU Hopital Gabriel Montpied
city: Lille
country: France
facility: Hopital Roger Salengro Service de Neurologie
city: Nancy
country: France
facility: CHU Nancy Hôpital Central
city: Nice Cedex 1
country: France
facility: CHU Nice - Hôpital Pasteur 2
city: Poissy
country: France
facility: Centre Hospitalier Intercommunal de Poissy
city: Strasbourg
country: France
facility: CHU Strasbourg Hpital Hautepierre
city: Duesseldorf
country: Germany
facility: Universitaetsklinikum Duesseldorf
state: Nordrhein Westfalen
city: Bayreuth
country: Germany
facility: Klinikum Bayreuth Standort Hohe Warte Klinik fur Neurologie
city: Berlin
country: Germany
facility: Charité Universitaetsmedizin Berlin - Campus Ch
city: Berlin
country: Germany
facility: Jüdisches Krankenhaus Berlin
city: Bonn
country: Germany
facility: Neurologie in Bonn
city: Dresden
country: Germany
facility: Universitaetsklinikum Carl Gustav Carus TU Dresden
city: Essen
country: Germany
facility: Zentrum fuer ambulante Neurologie
city: Frankfurt
country: Germany
facility: Klinikum der Johann Wolfgang Goethe-Universitaet
city: Gießen
country: Germany
facility: Universitaetsklinikum Giessen und Marburg GmbH
city: Leipzig
country: Germany
facility: Universitaetsklinikum Leipzig
city: Mittweida
country: Germany
facility: Pharmakologisches Studienzentrum
city: Muenster
country: Germany
facility: Universitaetsklinikum Muenster
city: München
country: Germany
facility: Klinikum rechts der Isar der TU Muenchen
city: Regensburg
country: Germany
facility: Medizinische Einrichtungen des Bezirks Oberpfalz GmbH
city: Tübingen
country: Germany
facility: Universitaetsklinikum Tuebingen
city: Ulm
country: Germany
facility: Universitätsklinikum Ulm
city: Westerstede
country: Germany
facility: Studienzentrum Nordwest Dr med Joachim Springub Herr Wolfgang Schwarz
city: Budapest
country: Hungary
facility: S-Medicon Egeszsegugyi Szolgaltato Kft.
city: Budapest
country: Hungary
facility: Jahn Ferenc Del-Pesti Korhaz es Rendelointezet
city: Pecs
country: Hungary
facility: Pecsi Tudomanyegyetem
city: Jerusalem
country: Israel
facility: Hadassah University Hospital - Ein Kerem
city: Petach Tikva
country: Israel
facility: Rabin Medical Center Beilinson Campus
city: Ramat Gan
country: Israel
facility: Chaim Sheba Medical Center
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center
city: Ponderano
country: Italy
facility: Ospedale degli Infermi
state: Friuli-Venezia Giulia
city: Roma
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico Tor Vergata
state: Lazio
city: Roma
country: Italy
facility: Azienda Ospedaliera Sant'Andrea-Universitr di Roma La Sapien
state: Lazio
city: Genova
country: Italy
facility: Ospedale Policlinico San Martino
state: Liguria
city: Milano
country: Italy
facility: Hospital San Raffaele
state: Lombardia
city: Milano
country: Italy
facility: Fondazione IRCCS Istituto Neurologico Carlo Besta
state: Lombardia
city: Montichiari
country: Italy
facility: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
state: Lombardia
city: Torrette Di Ancona
country: Italy
facility: Azienda Ospedaliero Universitaria Ospedali Riuniti
state: Marche
city: Orbassano
country: Italy
facility: Azienda Sanitaria Ospedaliera S Luigi Gonzaga
state: Piemonte
city: Cefalù
country: Italy
facility: Fondazione Istituto G. Giglio di Cefalu
state: Sicilia
city: Gallarate
country: Italy
facility: Azienda Socio Sanitaria Territoriale della Valle Olona (pres
state: Valle D?Aosta
city: Riga
country: Latvia
facility: Maritime Medicine Centre of Latvia Hospital of Vecmilgravis Department of Neurology
city: Riga
country: Latvia
facility: Pauls Stradins Clinical University Hospital
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics Public Institution
city: Klaipeda
country: Lithuania
facility: Klaipeda University Hospital Public Institution
city: Vilnius
country: Lithuania
facility: Vilnius University Hospital Santaros Klinikos
city: Ciudad de México
country: Mexico
facility: Mexico Centre for Clinical Research
state: Mexico CITY (federal District)
city: Guadalajara
country: Mexico
facility: Hospital Mexico Americano
state: Mexico CITY (federal District)
city: Tlalnepantla de Baz
country: Mexico
facility: Clinical Research Institute
state: Mexico CITY (federal District)
city: Monterrey
country: Mexico
facility: Hospital Universitario Dr Jose Eleuterio Gonzalez
state: Nuevo LEON
city: Monterrey
country: Mexico
facility: Centro de Estudios Clinicos y Especialidades Medicas S C
state: Nuevo LEON
city: Culiacan
country: Mexico
facility: Hospital Angeles Culiacan
state: Sinaloa
city: Aguascalientes
country: Mexico
facility: Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V. Aguascalientes
city: Chihuahua
country: Mexico
facility: Hospital Angeles Chihuahua
city: Mexico
country: Mexico
facility: Grupo Medico Camino
city: Sittard-Geleen
country: Netherlands
facility: Zuyderland Medisch Centrum - Sittard-Geleen'
city: Hamilton
country: New Zealand
facility: Waikato Hospital
city: Bergen
country: Norway
facility: Haukeland Universitetssykehus
city: Bydgoszcz
country: Poland
facility: NZOZ Vitamed
city: Gda?sk
country: Poland
facility: COPERNICUS Podmiot Leczniczy Sp z o o
city: Katowice
country: Poland
facility: M.A. LEK A.M.Maciejowscy SC.
city: Katowice
country: Poland
facility: Specjal. Praktyka Lekarska
city: Katowice
country: Poland
facility: Neuro-Medic Janusz Zbrojkiewicz
city: Krakow
country: Poland
facility: Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii K
city: Lodz
country: Poland
facility: Centrum Neurologii Krzysztof Selmaj
city: Lublin
country: Poland
facility: Uniwersytecki Szpital Kliniczny nr 4 w Lublinie
city: Olsztyn
country: Poland
facility: Wojewodzki Specjalistyczny Szpital w Olsztynie
city: Plewiska
country: Poland
facility: Neurologiczny NZOZ Centrum Leczenia SM
city: Siemianowice ?l?skie
country: Poland
facility: Neuro-Care Gabriela Klodowska
city: Warszawa
country: Poland
facility: Centrum Medyczne NeuroProtect
city: Braga
country: Portugal
facility: Hospital de Braga
city: Coimbra
country: Portugal
facility: Centro Hospitalar E Universitário de Coimbra EPE
city: Lisboa
country: Portugal
facility: Unidade Local de Saude de Santa Maria, E.P.E. - Hospital de Santa Maria
city: Pragal
country: Portugal
facility: Hospital Garcia de Orta
city: Bucuresti
country: Romania
facility: Spitalul Universitar de Urgenta Elias
city: Campulung
country: Romania
facility: SC Clubul Sanatatii SRL
city: Barnaul
country: Russian Federation
facility: Siberian Medical Center
state: Altaj
city: Saransk
country: Russian Federation
facility: SBIH of Republic Mordoviya "Republican Clinical Hospital # 4"
state: Mordovija
city: Moskva
country: Russian Federation
facility: FGBU FNKC FMBA of Russia
state: Moskovskaja Oblast
city: Moskva
country: Russian Federation
facility: SBIH City Polyclinic 2 of the Department of Health of the City of Moscow
state: Moskovskaja Oblast
city: Sankt-peterburg
country: Russian Federation
facility: FSBMEI HPE "Military Medical Academy n.a. S.M. Kirov" of the MoD of the RF
state: Sankt Petersburg
city: Sankt-peterburg
country: Russian Federation
facility: SPb SBIH "City Multy-field Hospital # 2"
state: Sankt Petersburg
city: St. Petersburg
country: Russian Federation
facility: Pavlov First Saint Petersburg State Medical University
state: Sankt Petersburg
city: Pyatigorsk
country: Russian Federation
facility: SBIH of Stavropol territory " City Hospital # 2" of Pyatigorsk
state: Stavropol
city: Yekaterinburg
country: Russian Federation
facility: Sverdlovsk Regional Clinical Hospital 1
state: Sverdlovsk
city: Tyumen
country: Russian Federation
facility: Regional Multiple Sclerosis Centre b/o CC ECM Neftyanik
state: Tjumen
city: Kazan
country: Russian Federation
facility: SAHI "Interregional Clinical and Diagnostic Center"
state: Vologda
city: Perm
country: Russian Federation
facility: Perm SMA n.a. academ. E.A. Vagner
state: Vologda
city: Kemerovo
country: Russian Federation
facility: SAIH "Kemerovo Regional Clinical Hospital"
city: Kirov
country: Russian Federation
facility: Kirov RSBIH "Kirov City Clinical Hospital # 1"
city: Novosibirsk
country: Russian Federation
facility: FSBIH Siberian Clinical Center of FMBA of Novosibirsk
city: Samara
country: Russian Federation
facility: SBEI HPE "Samara State Medical University" of the MoH of the RF
city: Saratov
country: Russian Federation
facility: Saratov State Medical University
city: Smolensk
country: Russian Federation
facility: RSBIH "Smolensk Regional Clinical Hospital"
city: Kragujevac
country: Serbia
facility: Clinical Center Kragujevac
city: NIS
country: Serbia
facility: Clinical Center Nis
city: Banska Bystrica
country: Slovakia
facility: MUDr. Beata Dupejova Neurologicka ambulancia s.r.o
city: Bratislava
country: Slovakia
facility: Univerzitna nemocnica Bratislava Nemocnica Ruzinov
city: Žilina
country: Slovakia
facility: Fakultna nemocnica s poliklinikou Zilina
city: L'Hospitalet de Llobregat
country: Spain
facility: Hospital Universitari de Bellvitge
state: Barcelona
city: Salt
country: Spain
facility: Hospital Santa Caterina
state: Girona
city: Santiago de Compostela
country: Spain
facility: Complejo Hospitalario Universitario de Santiago (CHUS) Servicio de Neurologia
state: LA Coruna
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro - Majadahonda
state: Madrid
city: Bilbao
country: Spain
facility: Hospital de Basurto
state: Vizcaya
city: Barcelona
country: Spain
facility: Hospital Vall d'Hebron
city: Madrid
country: Spain
facility: Hospital Universitario de la Princesa
city: Madrid
country: Spain
facility: Hospital Universitario Ramon y Cajal
city: Madrid
country: Spain
facility: Hospital Universitario Clínico San Carlos
city: Malaga
country: Spain
facility: Hospital Regional Universitario de Malaga
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena
city: Göteborg
country: Sweden
facility: Sahlgrenska Sjukhuset
city: Stockholm
country: Sweden
facility: Akademiskt Specialist Centrum
city: Basel
country: Switzerland
facility: Universitaetsspital Basel
city: Lugano
country: Switzerland
facility: Ospedale Regionale di Lugano
city: Mannouba
country: Tunisia
facility: Hopital Razi
city: Monastir
country: Tunisia
facility: Hopital Universitaire Fattouma Bourguiba
city: Istanbul
country: Turkey
facility: Istanbul University Cerrahpasa Medical Faculty
city: Samsun
country: Turkey
facility: Ondokuz Mayis Univ. Med. Fac.
city: Trabzon
country: Turkey
facility: Karadeniz Tecnical Uni. Med. Fac
city: Vinnytsia
country: Ukraine
facility: Medical Center of Limited Liability Company Medical Center Saliutem
state: Chernihiv Governorate
city: Dnipro
country: Ukraine
facility: Separated structural unit ?University hospital? of Dnipro State Medical University
state: Dnipropetrovs'ka Oblast
city: Kharkiv
country: Ukraine
facility: Institute of Neurology Psychiatry and Narcology of NAMS of Ukraine
state: Kharkiv Governorate
city: Lviv
country: Ukraine
facility: Communal noncommercial enterprise of Lviv Regional Council Lviv Regional Clinical Hospital
state: Kharkiv Governorate
city: Chernihiv
country: Ukraine
facility: CMPI Chernihiv Regional Hospital
state: KIEV Governorate
city: Ivano Frankivsk
country: Ukraine
facility: CNE Regional Clinical Hospital of Ivano-Frankivsk Regional Council
state: KIEV Governorate
city: Kyiv
country: Ukraine
facility: Medical Center of Limited Liability Company Medbud-Clinic
state: KIEV Governorate
city: Lviv
country: Ukraine
facility: CNE of Lviv Reg Clin Hospital Dept of Neurology D.Halytskyi Lviv NMU
state: KIEV Governorate
city: Odesa
country: Ukraine
facility: CNE Odesa Regional Clinical Hospital of Odesa Regional Council
state: KIEV Governorate
city: Nottingham
country: United Kingdom
facility: Nottingham University Hospitals Queen's Medical Centre
state: Nottinghamshire
city: Exeter
country: United Kingdom
facility: Royal Devon and Exeter Hospital (Wonford)
city: Liverpool
country: United Kingdom
facility: Walton Centre For Neurology and Neurosurgery
city: London
country: United Kingdom
facility: Barts Health NHS Trust
city: Newcastle
country: United Kingdom
facility: Royal Victoria Infirmary
city: Swansea
country: United Kingdom
facility: Morriston Hospital
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
References: