Clinical trial NCT06804525: LHC-CIDI-5 in Hong Kong
Official title: Use of Life History Calendars to Enhance Measurement of Lifetime Experience With Mental Disorders in Hong Kong.
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Major Depressive Episode (MDE)
Major Depressive Disorder (MDD)
Persistent Depressive Disorder (PDD)
Suicidal Ideation
Suicidal Plan
Suicidal Attempt
Suicidal Gesture
Nonsuicidal Self-Injury
Manic Episode
Hypomanic
Bipolar I Disorder
Bipolar Sub Disorder
Bipolar II Disorder
Generalized Anxiety Disorder (GAD)
Intermittent Explosive Disorder (IED)
Panic Attack
Panic Disorder
Obsessive-Compulsive Disorder (OCD)
Posttraumatic Stress Disorder (PTSD)
PCL-SC PTSD
PCL-5 PTSD
Alcohol Use Disorder (AUD)
Substance Use Disorder (SUD)
Keywords: Life History Calendar
CIDI
Recall bias
Retrospective reporting
Lifetime prevalence
Mental disorders
Lead sponsor: The University of Hong Kong
Sponsor class: OTHER
First posted: 2025-02-03
Enrollment: 1000
Sex: ALL
Minimum age (years): 25
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: This study is a sub-study of the District Health Profile (DHP), which is a district-level representative descriptive cross-sectional study. In DHP, 1% of households in selected Hong Kong districts will be randomly selected from the Census and Statistics Department's list of quarters, with stratification based on districts and housing types; all persons aged 18 and above in the recruited households will be included and surveyed. For participants who consent to join the DHP study, a sub-sample of 1,000 participants aged 25 or above will be randomly selected and assigned to two groups through a random process. All 1,000 individuals will complete the survey for the DHP study, including the CIDI-5 section. When administering the CIDI-5, one group of 500 individuals will be interviewed using only the CIDI-5, while the other group of 500 individuals will be interviewed with LHC first, followed by the CIDI-5.

Brief summary: The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12 months, and lifetime) based on the diagnostic criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) and International Classification of Diseases 10th edition (ICD-10). However, retrospective measurements like the CIDI-5 are susceptible to recall bias, especially for the lifetime experience, which can hinder the reporting accuracy with mental disorders.

To mitigate this issue, the life history calendar (LHC) was introduced as an aid to assist respondents in recalling the timing of life events, enhancing the ability of the CIDI-5 to measure the lifetime prevalence of mental disorders. The LHC is a grid structure with columns representing time units and rows representing life domains under study.

In a study conducted in Nepal, combining the CIDI-5 with the LHC resulted in a significant increase in the detection of mental disorders compared to using the CIDI-5 alone. This approach did not lead to an increase in false positives after clinical validation.

This experiment aims to adapt a Hong Kong version of the LHC based on the Nepalese model and evaluate the effectiveness of the LHC-assisted CIDI-5 (LHC-CIDI-5) compared to the CIDI-5 alone in assessing mental disorders.


Eligibility criteria: Inclusion Criteria:

* All household members aged 25 years old and over are randomly sampled from the Census and Statistics Department List of Quarters
* Live in the address sampled from the Census and Statistics Department List of Quarters
* Reside in Hong Kong for at least six months in the past year
* Able to read and communicate in Chinese or English
* Without linguistic or cognitive difficulties

Exclusion Criteria:

* Domestic workers

Primary outcomes:
measure: Depression
timeFrame: Immediately following intervention or recruitment
measure: Persistent Depression
timeFrame: Immediately following intervention or recruitment
measure: Self Harm
timeFrame: Immediately following intervention or recruitment
measure: High Mood
timeFrame: Immediately following intervention or recruitment
measure: Worry and Anxiety
timeFrame: Immediately following intervention or recruitment
measure: Anger Attacks
timeFrame: Immediately following intervention or recruitment
measure: Panic Attacks
timeFrame: Immediately following intervention or recruitment
measure: Obsessions and Compulsions
timeFrame: Immediately following intervention or recruitment
measure: Stressful Experiences
timeFrame: Immediately following intervention or recruitment
measure: Tobacco, Alcohol, and Drugs
timeFrame: Immediately following intervention or recruitment
Secondary outcomes:
Other outcomes:
Locations:
city: Hong Kong, SAR
country: Hong Kong
facility: The University of Hong Kong
Study officials:
affiliation: The University of Hong Kong
name: Michael Y. Ni, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Amro I, Ali A, Hassan MHMO, Al Shawwaf M, Alhassan A, Al Bahari D, El Fakki H, Hijawi Z, Aly S, Amin A, Mohammed R, Nofal M, Abdelkader M, Salman S, Currie J, Alabdulla M, Sampson NA, First M, Kessler RC, Woodruff PW, Khaled SM. Design and field procedures for the clinical reappraisal of the Composite International Diagnostic Interview version 3.3 in Qatar's national mental health study. Int J Methods Psychiatr Res. 2023 Sep;32(3):e1958. doi: 10.1002/mpr.1958. Epub 2023 Jan 18.
citation: Axinn WG, Chardoul S, Gatny H, Ghimire DJ, Smoller JW, Zhang Y, Scott KM. Using life history calendars to improve measurement of lifetime experience with mental disorders. Psychol Med. 2020 Feb;50(3):515-522. doi: 10.1017/S0033291719000394. Epub 2019 Mar 11.