Clinical trial NCT00794404: Evaluation of Power Doppler US Technique for the Diagnosis of Spondylarthropathy
Official title: Evaluation of Power Doppler US Technique for the Diagnosis of Spondylarthropathy in Patients With Uncertain Diagnosis Consulting for Clinical Symptoms Suggestive of Spondylarthropathy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Spondylarthropathy
Ankylosing Spondyloarthitis
Spondyloarthritis
Lead sponsor: Groupe Français d'Etude Génétique des Spondylarthropathies
Sponsor class: OTHER
Collaborators: name: Groupe Français d'Etude Génétique des Spondylarthropathies
name: French Society of Rheumatology
First posted: 2008-11-20
Enrollment: 489
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with a symptomatology which can lead to a SPA diagnosis but with no confirmed diagnosis yet for any rheumatic didease.

Brief summary: The purpose of this study is to evaluate the interest of enthesis sonography for the diagnosis of spondylarthritis, in patients with uncertain diagnosis consulting for clinical symptoms suggestive of spondylarthritis

Detailed description: Spondylarthritis (SPA) are the second most frequent inflammatory rheumatic disorders and, because it starts early in life and has a chronic progressive course, the impact of this disease on health resources and patient's life quality can be important. Because the characteritic signs of SPA, like radiological evidence of sacro-iliitis, appear late in time, the lag time between the onset first signs of SPA for the patient and the confirmed diagnosis can be very long (up to 8 years). Previous studies proved that patients who are affected by SPA are showing abnormal vascularization of peripheral enthesis more frequently than patients affected by other rheumatic diseases. Ultrasonography in B mode combined with power Doppler (PDUS) is a non invasive and highly sensitive toll which can detect enthesitis and abnormal vsacularization even for the patients who are not showing yet the evidence of SPA's symptomatology. Using PDUS as a early diagnosis tool could lead to the improvement of diagnostic procedures and therapeutic management of SpA and reduce the cost of diagnosis for patient and health insurances.

Eligibility criteria: Inclusion Criteria:

* patients \< 50 years old, consulting for spinal inflammatory symptoms \> 3 months duration
* patients consulting for arthritis or tenderness joints \> 3 months duration
* patients \< 50 years old consulting for enthesitis or dactylitis \> 3 months duration
* patients with uveitis and HLA-B27 positivity
* relatives of SpA patients consulting for symptoms suggestive of SpA

Exclusion Criteria:

* patient with confirmed diagnosis of rheumatic disease (included SpA)
* patient protected by law (patient \<18 years old, pregnant woman)
* patient who can't atempt the RMI
* patient who will have difficulties to complete the two years of follow-up

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Boulogne Billancourt
country: France
facility: Ambroise Paré Hospital
city: Brest
country: France
facility: Cavale Blanche Hospital
city: Caen
country: France
facility: Cote de Nacre Hospital
city: Echirolles
country: France
facility: South Hospital of Grenoble
city: Marseille
country: France
facility: Conception Hospital
city: VANDOEUVRE les NANCY
country: France
facility: Nancy Brabois Hospital
Study officials:
affiliation: Ambroise Paré Hospital
name: D'AGOSTINO Maria-Antonietta, MCUPH
role: PRINCIPAL_INVESTIGATOR
References:
citation: Devauchelle-Pensec V, D'Agostino MA, Marion J, Lapierre M, Jousse-Joulin S, Colin D, Chary-Valckenaere I, Marcelli C, Loeuille D, Aegerter P, Guis S, Gaudin P, Breban M, Saraux A; Study Group of Spondylarthritis. Computed tomography scanning facilitates the diagnosis of sacroiliitis in patients with suspected spondylarthritis: results of a prospective multicenter French cohort study. Arthritis Rheum. 2012 May;64(5):1412-9. doi: 10.1002/art.33466.