Clinical trial NCT06260280: Chronic Sleep Deprivation and Changes in Cortical and Hippocampal Volume
Official title: Relationship Between Chronic Sleep Deprivation and Changes in Cortical and Hippocampal Volume Assessed by Nuclear Magnetic Resonance in First-Year Medical Residents
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Sleep Deprivation
Hippocampal Atrophy
Cortical Irregularity
Keywords: Sleep Deprivation
Hippocampal Atrophy
Cortical Irregularity
First-year medical residents
Lead sponsor: Instituto Mexicano del Seguro Social
Sponsor class: OTHER_GOV
First posted: 2024-02-15
Enrollment: 37
Sex: ALL
Minimum age (years): 24
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All first-year medical residents admitted to our hospital unit who meet the inclusion criteria will be informed of the purpose of the study and, after signing the informed consent, will undergo cranial magnetic resonance imaging.

Brief summary: Sleep is a physiological state that is essential for human performance, including academic, occupational, interpersonal, and psychological aspects. Sleep disruption or deprivation leads to a loss of psychomotor skills and an increased association with various diseases. Therefore, it is critical to assess how chronic sleep deprivation affects medical residents who work long shifts, including those assigned during their training.

Detailed description: Objective: To determine if there is an association between chronic sleep deprivation and changes in cortical and hippocampal volume, assessed by nuclear magnetic resonance, in first-year medical residents assigned to the High Specialty Medical Unit, Specialty Hospital No. 1, National Medical Center of Bajío, during a period of 2 months after their admission.

Materials and Methods: This is a retrospective cohort study of first-year residents at UMAE T1, with a calculated sample size of 37 patients. Results are presented using descriptive statistics with mean and standard deviation or median with confidence intervals, depending on the type of variable. The relationship between MRI values and sleep deprivation will be assessed using Pearson's correlation coefficient or its non-parametric equivalent.

Ethical considerations: The study will be conducted with the informed consent of the patients in accordance with the General Health Law on Research and the Helsinki Declaration of 1975. The risk associated with this study is more than minimal.

Resources: Magnetic resonance studies will be performed at the High Specialty Medical Unit, Specialty Hospital No. 1, National Medical Center of Bajio, under the supervision of affiliated physicians specializing in the field of radiology and a fourth year resident in Diagnostic and Therapeutic Imaging.

Eligibility criteria: Inclusion Criteria:

* New resident physicians assigned to the High Specialty Medical Unit, Hospital de Especialidades No. 1 Centro Médico Nacional Del Bajío.

Exclusion Criteria:

* - Patients who have ingested caffeine, nicotine or alcohol in the last 24 hours.
* Patients with sleep disorders who present a score greater than 5 in the initial assessment of the Pittsburgh Sleep Quality Index.
* Patients with psychiatric treatment.
* Patients ingesting medications that intervene in the awake state.
* Patients with drug abuse (marijuana, cocaine, etc.).
* Patients with claustrophobia.
* Patients with metallic implants.

Primary outcomes:
measure: Change in Hippocampal volumetry.
timeFrame: 2 months
measure: Change in cortical volumetry
timeFrame: 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: Leon
country: Mexico
facility: Unidad Medica de Alta Especialidad No. 1, Bajío
state: Guanajuato
Study officials:
affiliation: Instituto Mexicano del Seguro Social
name: Hilda E Macias, PhD
role: PRINCIPAL_INVESTIGATOR
References:
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