Clinical trial NCT05910762: Human Learning of New Structured Information Across Time and Sleep
Official title: Learning Novel Structure Across Time and Sleep
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Learning
Humans
Consolidation
Sleep
Keywords: memory
sleep
learning
Lead sponsor: University of Pennsylvania
Sponsor class: OTHER
Collaborators: name: National Institute of Mental Health (NIMH)
First posted: 2023-06-20
Enrollment: 105
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Acting adaptively requires quickly picking up on structure in the environment and storing the acquired knowledge for effective future use. Dominant theories of the hippocampus have focused on its ability to encode individual snapshots of experience, but the investigators and others have found evidence that it is also crucial for finding structure across experiences. The mechanisms of this essential form of learning have not been established. The investigators have developed a neural network model of the hippocampus instantiating the theory that one of its subfields can quickly encode structure using distributed representations, a powerful form of representation in which populations of neurons become responsive to multiple related features of the environment.

The first aim of this project is to test predictions of this model using high resolution functional magnetic resonance imaging (fMRI) in paradigms requiring integration of information across experiences. The results will clarify fundamental mechanisms of how humans learn novel structure, adjudicating between existing models of this process, and informing further model development. There are also competing theories as to the eventual fate of new hippocampal representations. One view posits that during sleep, the hippocampus replays recent information to build longer-term distributed representations in neocortex. Another view claims that memories are directly and independently formed and consolidated within the hippocampus and neocortex.

The second aim of this project is to test between these theories. The investigators will assess changes in hippocampal and cortical representations over time by re-scanning participants and tracking changes in memory at a one-week delay. Any observed changes in the brain and behavior across time, however, may be due to generic effects of time or to active processing during sleep.

The third aim is thus to assess the specific causal contributions of sleep to the consolidation of structured information. The investigators will use real-time sleep electroencephalography to play sound cues to bias memory reactivation. The investigators expect that this work will clarify the anatomical substrates and, critically, the nature of the representations that support encoding and consolidation of novel structure in the environment.


Eligibility criteria: Inclusion Criteria:

* Between 18 and 35 years of age (all aims)
* Not a member of a vulnerable population (all aims)
* Normal or corrected-to-normal vision (all aims)
* Normal hearing (all aims)
* Able to speak English fluently (all aims)
* No prior history of major psychiatric or neurological disorders (Aims 1 and 2; MRI-specific)
* Not currently taking any antidepressants or sedatives (Aims 1 and 2; MRI-specific)
* No known neurological disorders (Aim 3; EEG-specific)

Exclusion Criteria:

* The investigators will exclude individuals with MR contraindications such as non-removable biomedical devices or metal in or on the body (Aims 1 and 2; MRI-specific)
* Claustrophobia (Aims 1 and 2; MRI-specific)
* Pregnant women will also be excluded from neuroimaging, as the effects of MR on pregnancy are not fully understood (Aims 1 and 2; MRI-specific)

Primary outcomes:
measure: Changes in multivariate representations
timeFrame: Within first session (spanning 2-3 hrs.) and at approximately one week delay in second session (spanning 1-2 hrs.)
measure: Brain-behavior correlations
timeFrame: Within first session (spanning 2-3 hrs.) and at approximately one week delay in second session (spanning 1-2 hrs.)
measure: Correlations between activity across brain regions
timeFrame: Within first session (spanning 2-3 hrs.) and at approximately one week delay in second session (spanning 1-2 hrs.)
measure: Memory accuracy
timeFrame: Within single study session (spanning 4-5 hrs.)
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: University of Pennsylvania
state: Pennsylvania
Study officials:
affiliation: University of Pennsylvania
name: Anna C Schapiro, PhD
role: PRINCIPAL_INVESTIGATOR
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