louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05428046: Preventing Eating Disorders by Improving Mental Health Literacy in Chinese Adolescents
Official title: Preventing Eating Disorders by Improving Mental Health Literacy in Chinese Adolescents: A Non-randomized Cluster Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Eating Disorders
Mental Health Literacy
Lead sponsor: Peking University
Sponsor class: OTHER
First posted: 2022-06-22
Enrollment: 1395
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Mental health literacy (MHL) is necessary for the prevention, detection, and treatment of eating disorders, whereas the MHL about eating disorders is inadequate in China. Thus, the current study aimed to improve the MHL for eating disorders among Chinese adolescents via a brief online intervention.


Eligibility criteria: Inclusion Criteria:

* Middle school students

Exclusion Criteria:

-

Primary outcomes:
measure: Eating disorders mental health literacy
timeFrame: pre-intervention, post-intervention, 4 weeks follow-up, 12 weeks follow-up
measure: social distance scale
timeFrame: pre-intervention, post-intervention, 4 weeks follow-up, 12 weeks follow-up
Secondary outcomes:
measure: Weight Concerns Scale
timeFrame: pre-intervention, post-intervention, 4 weeks follow-up, 12 weeks follow-up
measure: The SCOFF
timeFrame: pre-intervention, post-intervention, 4 weeks follow-up, 12 weeks follow-up
measure: Actual help-seeking behavior
timeFrame: pre-intervention, post-intervention, 4 weeks follow-up, 12 weeks follow-up
measure: Patient Health Questionnaire-4
timeFrame: pre-intervention, post-intervention, 4 weeks follow-up, 12 weeks follow-up
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University
state: Beijing
Study officials:
References:
Clinical trial NCT06960746: Changing Lifestyle in OSA Males Who Suffer Metabolic Syndrome and Impotence: Is There a Response?
Official title: Effect of Addition of Changing Lifestyle to CPAP in OSA Males Who Suffer Metabolic Syndrome and Impotence
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Obstructive Sleep Apnea
Erectile Dysfunction
Metabolic Syndrome
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2025-05-07
Enrollment: 40
Sex: MALE
Minimum age (years): 40
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The problems like metabolic syndrome and sexual impotence in males with obstructive sleep apnea are common. continuous passive airway pressure (CPAP) is an authorized treatment for this type of apnea but still the recommendations of changing lifestyles are the suggested cornerstone therapies especially in obese males

Detailed description: Forty males with metabolic syndrome, sexual impotence (erectile dysfunction), and obstructive sleep apnea will be randomized to control group (CPAP will be applied in this group that will contain 20 males, CPAP will be applied five days weekly during night-sleeping for 4 hours for 12 weeks ) and study 20-patient group (also CPAP will be applied with the same protocol of control group plus lifestyle changes that will contain 3-session per-week 40-minute treadmill exercising and low-caloric/dietary 12-week restriction)

Eligibility criteria: Inclusion Criteria:

* moderate and severe obstructive sleep apnea
* erectile dysfunction (mild and moderate)
* metabolic syndrome men

Exclusion Criteria:

* cardiac patients
* psychiatric men
* autoimmune diseased men
* renal diseased men

Primary outcomes:
measure: international index of erectile function (five-item Arabic version)
timeFrame: it will be measured after 12 weeks
Secondary outcomes:
measure: index of apnea and hypopnea
timeFrame: It will be measured after 12 weeks
measure: ration of oxygen desaturation per hour
timeFrame: It will be measured after 12 weeks
measure: Epworth sleepiness scale
timeFrame: It will be measured after 12 weeks
measure: body mass index
timeFrame: it will be measured after 12 weeks
measure: neck circumference
timeFrame: It will be measured after 12 weeks
measure: fasting glycemia
timeFrame: It will be measured after 12 weeks
measure: high density lipoprotein
timeFrame: It will be measured after 12 weeks
measure: triglycerides
timeFrame: It will be measured after 12 weeks
measure: systolic blood pressure
timeFrame: It will be measured after 12 weeks
measure: diastolic blood pressure
timeFrame: It will be measured after 12 weeks
measure: waist circumference
timeFrame: It will be measured after 12 weeks
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Faculty of physical therapy
state: Dokki
Study officials:
affiliation: Cairo University
name: Ali MA Ismail, lecturer
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05307146: Brain Activity in Epilepsy
Official title: Study of Brain Activity in Candidates for Epilepsy Surgery
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Epilepsy
Lead sponsor: Universitaire Ziekenhuizen KU Leuven
Sponsor class: OTHER
First posted: 2022-04-01
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Prospective interventional study with implantation of micro-electrodes to study the brain networks in epilepsy at high spatiotemporal resolution.

Detailed description: The goal of this trial is to study brain activity in epilepsy at high spatiotemporal resolution. Apart from the epileptogenic network (dysfunctional areas), the investigators will study human brain function.

The use of micro-electrode arrays allows to study the human brain a high spatiotemporal resolution, even at the single neuron level.

Scientific objectives of the current project:

* To record neural signals from macro-electrodes and delineate the epileptogenic network and study brain function during specific tasks.
* To record neural signals from micro-electrodes and delineate the epileptogenic network and study brain function during specific tasks.
* Identifying pivotal regions for BMI applications and developing online decoding algorithms.
* Comparing neural recordings to fMRI activity

Eligibility criteria: Inclusion Criteria:

* Age ≥18 yo
* Epilepsy patients undergoing intracranial electrode placement.
* Able to understand the procedure involved and to consent.

Exclusion Criteria:

* Age \< 18 yo
* Pregnancy

Primary outcomes:
measure: Electrophysiological recordings: single neuron recordings
timeFrame: 15 years
measure: Electrophysiological recordings: LFP
timeFrame: 15 years
measure: fMRI recordings
timeFrame: 15 years
Secondary outcomes:
measure: Neurophysiological study of different brain areas: power gamma band
timeFrame: 15 years
measure: Neurophysiological study of different brain areas: spike activity
timeFrame: 15 years
measure: Neurophysiological study of different brain areas: fMRI
timeFrame: 15 years
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: UZ Leuven
Study officials:
References:
Clinical trial NCT04789746: Ready, Set, Go! A Physical Fitness Intervention for Children With Mobility Challenges
Official title: Ready, Set, Go! A Physical Fitness Intervention for Children With Mobility Challenges
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Cerebral Palsy
Myelomeningocele
Arthrogryposis
Motor Skills Disorders
Gross Motor Development Delay
Lead sponsor: Northwestern University
Sponsor class: OTHER
Collaborators: name: Chicago Run
name: American Academy of Cerebral Palsy and Developmental Medicine
name: Spencer Foundation
First posted: 2021-03-10
Enrollment: 25
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Barriers to keeping and maintaining fitness as a young person with a disability exist across many domains of access to community locations such as fitness centers, so looking outside of these establishments may be necessary to advance fitness. This study is aimed at piloting a program that would address some of these barriers by hosting a modified after school running program with an underserved population in an accessible way. There is a second option to participate outside of school.


Eligibility criteria: Inclusion Criteria:

* a medical diagnosis (for example, cerebral palsy) that causes them mobility limitations

Exclusion Criteria:

* concurrent medical condition that would make exercise unsafe,
* are unable to follow simple commands
* have behaviors that would potentially compromise safety of fellow runners or caregivers

Primary outcomes:
measure: Goal attainment scale
timeFrame: at 8 weeks.
measure: 6 min walk test
timeFrame: baseline
measure: 6 min walk test
timeFrame: at 8 weeks
measure: 30 second walk test
timeFrame: baseline
measure: 30 second walk test
timeFrame: at 8 weeks
measure: Resting heart rate
timeFrame: baseline
measure: Resting heart rate
timeFrame: at 8 weeks
Secondary outcomes:
measure: Surveys
timeFrame: baseline
measure: Surveys
timeFrame: at 8 weeks
measure: Selective Control Assessment of the Lower Extremity (SCALE)
timeFrame: baseline
measure: Selective Control Assessment of the Lower Extremity (SCALE)
timeFrame: at 8 weeks
Other outcomes:
Locations:
city: Chicago Heights
country: United States
facility: Northwestern University
state: Illinois
Study officials:
References:
Clinical trial NCT02132546: Spectrophotometric Evaluation of Chlorhexidine Pigmentations After Oral Surgery: a Prospective Randomized Clinical Trial
Official title: Spectrophotometric Evaluation of Chlorhexidine Pigmentations After Periodontal Flap Surgery: a Prospective Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Staining Effect of Chlorhexidine
Lead sponsor: University of Trieste
Sponsor class: OTHER
First posted: 2014-05-07
Enrollment: 60
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The aim of this clinical trial was to evaluate through a clinical spectrophotometric analysis the staining side effect of a 0.2% CHX mouthwash containing an anti discoloration system (ADS) compared with a 0.12% and a 0.2% CHX alone mouthwash after periodontal surgery. The efficacy of the products and the patient's opinion and acceptance were also assessed.


Eligibility criteria: Inclusion Criteria:

* Good general health conditions without a medical history of medication that might interfere with periodontal tissues
* Good plaque control (FMPS ≤ 25%) and low levels of infection (FMBS ≤ 25%)
* Need for periodontal surgery

Exclusion Criteria:

* Smokers
* Allergy to CHX
* Lack of written informed consent

Primary outcomes:
measure: Change in ΔE before and after the use of chlorhexidine
timeFrame: Change from Baseline of ΔE after the use of chlorhexidine mouthrinses; change from Baseline of ΔE after the use of chlorhexidine mouthrinses at 1 week; change from Baseline of ΔE after the use of chlorhexidine mouthrinses at 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Trieste
country: Italy
facility: Ospedale Maggiore
Study officials:
References:
Clinical trial NCT05933746: Sleep Hygiene Intervention on Undergraduate Students' Sleep and Stress
Official title: The Impact of a Remote, Brief, Sleep Hygiene Intervention on Undergraduate Students' Sleep and Stress: A Randomized, Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stress, Emotional
Sleep Disturbance
Lead sponsor: Wayne State University
Sponsor class: OTHER
First posted: 2023-07-06
Enrollment: 108
Sex: ALL
Minimum age (years): 18
Maximum age (years): 24
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Poor sleep is common among college students and likely contributes to stress. The investigators developed a brief, remotely-delivered intervention and tested whether it improves sleep hygiene and reduced sleep disturbance and stress among undergraduates.

Detailed description: Poor sleep is common among college students and likely contributes to stress. The investigators developed a brief, remotely-delivered sleep hygiene intervention, which is delivered via the internet, and tested in a randomized controlled trial, whether it improves sleep hygiene and reduced sleep disturbance and stress in a sample of undergraduates who report wanting to improve their sleep. This study compares the novel sleep hygiene intervention to an active, matched control condition--sleep education. Baseline and 2-week follow-up questionnaires assess sleep hygiene, sleep disturbance, and stress. ANCOVAs will compare conditions at follow-up, and mediation tests will explore whether the intervention reduced stress through improved sleep.

Eligibility criteria: Inclusion Criteria:

* Undergraduate students at Wayne State University
* Self-reported desire to improve their sleep

Exclusion Criteria:

* Graduate students / professional students

Primary outcomes:
measure: Sleep disturbance short-form b
timeFrame: Change from baseline to 2-week follow-up
Secondary outcomes:
measure: Perceived Stress Scale
timeFrame: Change from baseline to 2-week follow-up
measure: Sleep Hygiene Inventory
timeFrame: Change from baseline to 2-week follow-up
Other outcomes:
Locations:
city: Detroit
country: United States
facility: Wayne State University
state: Michigan
Study officials:
References:
Clinical trial NCT06860646: Myocardial Infarction in the Elderly
Official title: Hospital Registry of Patients with Myocardial Infarction in Individuals Aged 75 Years and Older
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Myocardial Infarction (MI)
Lead sponsor: Ryazan State Medical University
Sponsor class: OTHER
First posted: 2025-03-06
Enrollment: 1000
Sex: ALL
Minimum age (years): 75
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients hospitalized in the State Budgetary Institution of the Ryazan Region "Regional Clinical Cardiology Dispensary" with an established diagnosis of myocardial infarction

Brief summary: An observational registry study of patients aged 75 years and older with an established diagnosis of myocardial infarction, initiated in 2020, with an assessment of clinical, instrumental, demographic and prognostic data. Statistical analysis was performed using the StatTech v. 4.5.0 program (developer - StatTech LLC, Russia). Differences were considered statistically significant at p \<0.05.


Eligibility criteria: Inclusion Criteria:

- age 75 years and older, presence of an established diagnosis of myocardial infarction at the time of hospitalization.

Exclusion Criteria:

-

Primary outcomes:
measure: all-cause death, myocardial infarction, stroke, unplanned percutaneous coronary
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Ryazan
country: Russian Federation
facility: State Budgetary Institution of the Ryazan Region "Regional Clinical Cardiology Dispensary"
Study officials:
References:
Clinical trial NCT06813846: Assessment of Pink Esthetic Score After Using Two Papilla Reconstruction Exposure Techniques Versus Mid-Crestal Sulcular Incision in Second Stage Implant Surgery: a Randomized Controlled Clinical Trail
Official title: Assessment of Pink Esthetic Score After Using Two Papilla Reconstruction Exposure Techniques Versus Mid-Crestal Sulcular Incision in Second Stage Implant Surgery: a Randomized Controlled Clinical Trail
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Papilla Reconstruction
Lead sponsor: British University In Egypt
Sponsor class: OTHER
First posted: 2025-02-07
Enrollment: 33
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The purpose of this randomized clinical trial is to assess the pink esthetic score with three different techniques in second-stage implant surgery.


Eligibility criteria: Inclusion Criteria:

1. Patients who already received implants in the anterior and premolar region
2. All implants were placed 4 months prior to uncovering in the mandible and 6 months prior to uncovering in the maxilla.
3. Patients with good oral hygiene
4. Medically free patients
5. Adequate keratinized tissue

Exclusion Criteria:

1. Acute infection
2. Occlusal trauma
3. Smokers
4. Pregnancy and lactation
5. Severe gag reflex

Primary outcomes:
measure: Pink Esthetic Score
timeFrame: 6 Months
Secondary outcomes:
measure: Healing Index
timeFrame: 1 Month
measure: Volumetric Changes
timeFrame: baseline, 3, 6 and 9 months
measure: Visual analogue scale
timeFrame: 2 Weeks
measure: The Oral health impact profile (OHIP-14 questionnaire)
timeFrame: 6 Months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Dentistry - The British University in Egypt
Study officials:
References:
Clinical trial NCT02740946: Enhanced Function and Quality of Life Following 5 Months of Exercise Therapy for Patients With Rotator Cuff Tears
Official title: Enhanced Function and Quality of Life Following 5 Months of Exercise Therapy for Patients With Irreparable Rotator Cuff Tears - an Intervention Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Full Thickness Rotator Cuff Tear
Lead sponsor: Northern Orthopaedic Division, Denmark
Sponsor class: OTHER
First posted: 2016-04-15
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study aims to evaluate the effect of 5 months of exercise therapy for patients with irreparable rotator cuff tears.

Detailed description: All included patients will receive exercise therapy consisting of two exercises focusing on strengthening m. deltoideus anterior and m. teres minor.

Eligibility criteria: Inclusion Criteria:

* symptoms of rotator cuff rupture for at least three months with rupture of minimum musculus supraspinatus and musculus infraspinatus visualized by ultrasonography or arthroscopy
* no neurological conditions which could affect muscle strength or activity
* able to read and understand Danish
* both patients with and without a history of shoulder trauma were included

Exclusion Criteria:

* former rotator cuff surgery
* history of shoulder fracture or inflammatory conditions in the shoulder
* significant osteoarthritic changes on antero-posterior and/or lateral (outlet view) radiographs

Primary outcomes:
measure: Oxford Shoulder Score
timeFrame: Baseline, 3 months and 5 months
Secondary outcomes:
measure: EuroQuol 5 Dimensions 5 Level EQ-5D-5L
timeFrame: baseline and 5 months
measure: Range of motion
timeFrame: Baseline and 5 months
measure: Strength
timeFrame: Baseline and 5 months
measure: Dynamic flexion in degrees from 0 to 180
timeFrame: Baseline and 5 months
measure: Muscle activity using surface electromyography
timeFrame: Baseline and 5 months
measure: Pain
timeFrame: Baseline and 5 months
Other outcomes:
Locations:
city: Aalborg
country: Denmark
facility: Northern Orthopaedic Division, Aalborg University Hospital
state: North Denmark Region
Study officials:
affiliation: Northern Orthopaedic Division, Aalborg University Hospital
name: Sten Rasmussen, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Christensen BH, Andersen KS, Rasmussen S, Andreasen EL, Nielsen LM, Jensen SL. Enhanced function and quality of life following 5 months of exercise therapy for patients with irreparable rotator cuff tears - an intervention study. BMC Musculoskelet Disord. 2016 Jun 8;17:252. doi: 10.1186/s12891-016-1116-6.
Clinical trial NCT00264446: A Study of ADH300004 in Surgically Resected Primary or Metastatic Colorectal Cancer and Liver Biopsy, or Planned Hepatic Resection
Official title: Phase 1 Study of the Evaluation of Dihydropyrimidine Dehydrogenase (DPD), Uridine Phosphorylase (UP), Orotate Phosphoribosyl Transferase (OPRT), and Thymidine Phosphorylase (TP) Activity in Tissue Resected From Subjects Undergoing Planned Resection of Primary or Metastatic Colorectal Cancer and Liver Biopsy, or Planned Hepatic Resection, Following Administration of Oral ADH300004 (Adherex Protocol Number AHX-03-101)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Neoplasms
Keywords: Cancer; Tumors; Neoplasms; Anticarcinogenic Agents; Antineoplastic Agents;
Dihydrouracil dehydrogenase (NADP); Colorectal Carcinoma; Liver Cancer
Lead sponsor: Adherex Technologies, Inc.
Sponsor class: INDUSTRY
First posted: 2005-12-13
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: 5 fluorouracil (5 FU), one of the most actively investigated anti-cancer drugs, is rapidly inactivated by the enzyme dihydropyrimidine dehydrogenase (DPD). ADH300004 blocks DPD. This study will examine the kinetics of inhibition and recovery of the metabolic pathways for fluoropyrimidines in subjects who receive a single oral dose of ADH300004, and may allow optimization of oral 5 FU dosing to subjects in future studies.


Eligibility criteria: Inclusion Criteria:

* Signed written informed consent
* \> or = 19 years of age
* Patients with histologically confirmed:

  * primary or metastatic (known or suspected) colorectal carcinoma requiring planned surgical resection with hepatic biopsy and systemic chemotherapy , or
  * primary or metastatic neoplastic disease within the liver from any origin requiring planned surgical resection and systemic chemotherapy
* Adequate performance status and organ function, as evidenced by hematological and biochemical blood testing

Exclusion Criteria:

* Lack of known or suspected metastatic disease in the liver
* Known DPD deficiency
* Severe infection
* Inability to take oral medication
* The need for treatment with any fluoropyrimidine within 8 weeks of any ADH300004 dose
* Stroke, major surgery, or other major tissue injury within 30 days before study entry

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: UAB - Division of Surgery
state: Alabama
Study officials:
affiliation: University of Alabama at Birmingham
name: Martin Heslin, MD
role: PRINCIPAL_INVESTIGATOR
References: