louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05892367: Transbrachial Access for Interventions in Patients With Peripheral Arterial Occlusive Disease
Official title: Transbrachial Access for Interventions in Patients With Peripheral Arterial Occlusive Disease: Evaluation of Local Complications With or Without Post-interventional Immobilization of the Upper Extremity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Complication of Treatment
Keywords: transbrachial access, intervention, bleeding, hematoma
Lead sponsor: Wilhelminenspital Vienna
Sponsor class: OTHER
First posted: 2023-06-07
Enrollment: 95
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Control group: compression bandage Study group: compression bandage and positioning splint
Primary purpose: PREVENTION

Brief summary: The aim of the present study is an evaluation, whether an immobilization of the upper extremity by means of a positioning splint can help to reduce the incidence of local complications after transbrachial puncture for peripheral arterial interventions, or not.

Detailed description: Increasing numbers of peripheral arterial interventions are performed via transbrachial access leading to a higher number of local complications at the puncture site. Patients are demonstrating complications, such as hematoma, false aneurysm, secondary hemorrhage and arterial stenosis or occlusion.

Due to not standardized post-interventional procedure regarding to immobilization a higher risk for local puncture site complication can occur. Usually, a compression bandage its applied to the brachial puncture site. Within this randomized study, patients randomized to the study group will receive an additional splint for 24 hours to ensure an immobilization of the affected arm.

Following the removal of the compression dressing, and the splint in the study group, a duplex ultrasound its performed in order to detect local alterations and pathologies of the brachial artery.

This examination is repeated for each patient in the course of an outpatient control six weeks post-interventionally. Pathologies are documented and treated if necessary.

Eligibility criteria: Inclusion Criteria:

* Female and male patients suffering from peripheral arterial occlusive disease with indicated interventions via an transbrachial access (puncture of the left or right brachial artery)
* age \> 18 years
* approval to participate

Exclusion Criteria:

* unability or refusal to participate
* dialysis patients/AV-fistula interventions
* usage of closure devices

Primary outcomes:
measure: Occurrence of local complications at the puncture site
timeFrame: 6 weeks
Secondary outcomes:
measure: Post-interventional pain at puncture site
timeFrame: 24 hours
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: Department of Vascular and Endovascular Surgery
Study officials:
affiliation: Vascular and Endovascular Surgery, Klinik Ottakring
name: Afshin Assadian, Prim. PD Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05025267: Ability to Meet Enteral Nutritional Needs with a Peptide-based, High Protein Formula
Official title: Prospective Study of Ability to Meet Nutritional Needs with a Peptide-based, High Protein Enteral Formula
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Enteral Feeding
Lead sponsor: Société des Produits Nestlé (SPN)
Sponsor class: INDUSTRY
First posted: 2021-08-27
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Prospective, single-arm, non-randomized, open-label observational study
Primary purpose: SUPPORTIVE_CARE

Brief summary: This is a prospective, open-label single-arm observational clinical trial to assess enteral feeding nutrition goals with a peptide-based, high protein enteral formula.

Detailed description: This is a prospective, observational study to assess the ability to meet enteral nutrition goals and tolerance of a peptide-based, high protein tube feeding product in adult, tube-fed patients living in the community setting. In addition, the study will explore metabolic and inflammatory markers.

Eligibility criteria: Inclusion Criteria:

* Adults with established enteral access
* Anticipated to require enteral nutrition to provide 90% or more of their nutritional needs
* Signed informed consent

Exclusion Criteria:

* Condition which contraindicates enteral feeding (i.e. intestinal obstruction)
* Any condition that would contraindicate use of the study product
* Patients with active colitis, radiation enteritis, SBS, undergoing active cancer treatment
* Judged to be at risk for poor compliance to the study protocol
* Participating in a conflicting clinical trial

Primary outcomes:
measure: Calorie nutritional goals
timeFrame: 14 days
Secondary outcomes:
measure: Protein nutritional goals
timeFrame: 14 days
measure: Daily reports of gastrointestinal intolerance
timeFrame: 14 days
measure: Adverse events
timeFrame: 14 days
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
Study officials:
affiliation: Nestle Health Science
name: Krysmaru Araujo Torres, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT03904667: Application of Watson for Oncology in Hepatocellular Carcinoma Surgery
Official title: Application of Watson for Oncology in Hepatocellular Carcinoma Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Liver Resection
Keywords: Watson artificial intelligence
hepatocellular carcinoma
surgical decisions
Lead sponsor: Zhujiang Hospital
Sponsor class: OTHER
First posted: 2019-04-05
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A total of 150 hepatocellular carcinoma patients admitted to the department of hepatobiliary surgery of zhujiang hospital of southern medical university from January 2017 to December 2021 were selected and divided into experimental group and control group

Brief summary: The aim of this study was to evaluate the surgical decisions of Watson artificial intelligence in patients with hepatocellular carcinoma.

Detailed description: Hepatectomy is an effective treatment for patients with hepatocellular carcinoma, but liver failure after hepatectomy may lead to increased postoperative mortality. Therefore, it is very important to make preoperative surgical decisions, evaluate the safety of the operation and identify which patients are likely to suffer from liver failure. The artificial intelligence platform developed by IBM Watson for Watson tumor treatment decisions can provide treatment decisions and corresponding theoretical basis to guide surgical decisions based on the key clinical data of liver cancer patients.

Eligibility criteria: Inclusion Criteria:

1. 18 years≤ Age ≤80 years
2. Compling with the diagnosis criteria of complex hepatic carcinoma.
3. Primary hepatic carcinoma without intrahepatic or extrahepatic extensive cancer metastasis, the metastatic hepatic carcinoma whose primary focal has been controlled
4. Preoperative liver function is Child - Pugh grade A or B.
5. The patients are volunteered for the study.

Exclusion Criteria:

1. Patients with mental illness.
2. Patients can't tolerate the operation owe to a variety of basic diseases (such as severe cardiopulmonary insufficiency, renal insufficiency, cachexia and blood system diseases, etc.)
3. The patients refused to take part in the study.
4. There are other co-existed malignant tumors.
5. Benign liver diseases

Primary outcomes:
measure: Operative outcomes
timeFrame: intraoperative
Secondary outcomes:
measure: Postoperative survival
timeFrame: 3 years
Other outcomes:
measure: Disease-free survival
timeFrame: 3 years
Locations:
city: Guangzhou
country: China
facility: Zhujiang Hospital of Southern Medical University
state: Guangdong
Study officials:
References:
Clinical trial NCT02555267: Geriatric Assessments in Elderly Diffuse Large B-cell Lymphoma
Official title: Multi-center, Prospective Cohort Study to Investigate the Impact of Comprehensive Geriatric Assessments on Survival and Toxicities in Elderly Diffuse Large B-cell Lymphoma Patients Treated With R-CHOP
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lymphoma, Large B-cell, Diffuse
Keywords: geriatric assessment
diffuse large B-cell lymphoma
activity of daily living
instrumental activity of daily living
Charlson's comorbidity index
Lead sponsor: Chonbuk National University Hospital
Sponsor class: OTHER
Collaborators: name: The Catholic University of Korea
name: Kyungpook National University Hospital
name: Keimyung University Dongsan Medical Center
name: Korea University Anam Hospital
name: Korea University Guro Hospital
name: Kosin University Gospel Hospital
name: Pusan National University Hospital
name: Soonchunhyang University Hospital
name: Ajou University School of Medicine
name: Chonnam National University Hospital
First posted: 2015-09-21
Enrollment: 148
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Elderly patients (≥ 65 years) with DLBCL treated with R-CHOP

Brief summary: This study investigate the impact of comprehensive geriatric assessments using activity of daily living (ADL), instrumental activity of daily living (IADL), and Charlson's comorbidity index (CCI) on survival and toxicities in Korean patients with diffuse large B-cell lymphoma (DLBCL) treated with R-CHOP.


Eligibility criteria: Inclusion Criteria:

* Patients with newly diagnosed CD20+ DLBCL
* 65 years old or over
* Scheduled to receive R-CHOP chemotherapy
* Informed consent

Exclusion Criteria:

* Other histology than CD20+ DLBCL
* Primary central nervous system DLBCL
* Patients with a diagnosis of cancer (other than basal or squamous cell carcinoma of the skin, cervical carcinoma in situ, well differentiated thyroid cancer \[papillary or follicular thyroid cancer\]) within 3 years before the study entry or with any treatment for cancer within 3 years before entry
* Consent withdrawal

Primary outcomes:
measure: Event-free survival
timeFrame: 2 years
Secondary outcomes:
measure: Overall survival
timeFrame: 5 years
measure: Progression-free survival
timeFrame: 5 years
measure: Cumulative incidence of grade 3/4 adverse events and premature treatment discontinuation
timeFrame: 1 year
Other outcomes:
measure: Average received relative dose intensity
timeFrame: 6 months
Locations:
city: Jeonju
country: Korea, Republic of
facility: Chonbuk National University Hospital
Study officials:
affiliation: Chonbuk National University Hospital
name: Ho-Young Yhim, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06205667: Computer Guided Versus Conventional Arthrocentesis in Management of Internal Derangements: A Randomized Clinical Study
Official title: Computer Guided Versus Conventional Arthrocentesis in Management of Internal Derangements: A Randomized Clinical Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: TMJ - Oral &Maxillofacial Surgery
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2024-01-16
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to evaluate the applicability, accuracy, benefits and the efficacy of 3-dimensional, printed, patient-specific guides to direct TMJ access for arthrocentesis when performed in contrast with conventional arthrocentesis of TMJ.


Eligibility criteria: Inclusion Criteria:

* Patients who complain from signs and symptoms of internal derangements and were diagnosed by the RDC/TMD as having disc displacement with/ without reduction with / without limitation associated with arthralgia or as having disc displacement with reduction associated with arthralgia in a presence or absence of joint sounds.
* Patients who did not responded to conservative treatment for a minimum of 3 months.
* Obtaining written informed consents signed by the patients.

Exclusion Criteria:

* Patients suffering from any muscular disorders as myofascial pain or myofascial pain with limitations
* If the disc was not visible in the MRI examination.
* Patients who previously received intra-articular injection of any medication or exposed to any other TMJ invasive procedure.
* Patients who suffer from any connective tissue diseases as rheumatoid arthritis or neurologic disorders.
* Patients with history of major jaw trauma, bisphosphonate-derived drug use, pregnancy, alcohol or drug dependence.
* Patients with gross mechanical restrictions or history of adhesion (fibrous or bony).
* Patients with psychiatric disease or substance abuse or have an allergy to the substance used in the study.

Primary outcomes:
measure: Attempts number of needle puncture
timeFrame: intraoperative
measure: Operation time started from first needle insertion.
timeFrame: intaoperative
Secondary outcomes:
measure: Maximum mouth opening
timeFrame: 1week, 1, 3 and 6
measure: Pain reduction
timeFrame: 1week, 1, 3 and 6
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ainshams university
Study officials:
References:
Clinical trial NCT03877367: Comparison of Balance Changes After Chiropractic Adjustments in Health Adults.
Official title: Immediate Impact of Extremity Manipulation on an Upper Extremity (UE) Balancing Task
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postural Balance
Musculoskeletal Manipulation
Keywords: Chiropractic manipulation
Extremity manipulation
Balance task
Lead sponsor: Parker University
Sponsor class: OTHER
Collaborators: name: University of Houston
name: Whittier University
name: University of Miami
name: Private Practice
First posted: 2019-03-15
Enrollment: 23
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: The study will be a patient and outcome assessor blinded, cross-over randomized clinical trial. Participants will randomized into two groups.
Primary purpose: TREATMENT

Brief summary: This study will examine the effect of upper and lower extremity manipulations on an upper extremity balancing task.

Detailed description: Spinal manipulation has long been thought to have beneficial effects on posture, balance and proprioception; however, only a single study has investigated the effect of chiropractic treatment of the extremities on balance and posture. In a previous study, it was noted that lower extremity manipulation led to more ordered behavior on a dynamic, lower extremity balance task. It was also found that upper extremity manipulation led to less ordered behavior with same lower extremity balance task. Further studies are needed not only to validate this theory, but to further clarify the mechanism regarding specificity of manipulation to task.

Eligibility criteria: Inclusion Criteria:

* Between the age 18 years old and 35 years old
* Cleared to be treated in Parker Wellness Clinic

Exclusion Criteria:

* Hx of neurological disorders
* Hx of musculoskeletal disorders/injuries that could impact his/her ability to stand upright
* Currently known to be pregnant
* Compromised vision (beyond the wearing of corrective lenses)

Primary outcomes:
measure: Head Sensor to calculate angle of head inclination
timeFrame: 30 seconds
Secondary outcomes:
measure: Ground reaction force
timeFrame: less than 1 minute
measure: Center of pressure
timeFrame: less than 1 minute
measure: Velocity to measure sway.
timeFrame: less than 1 minute
measure: Sway: measuring distance
timeFrame: less than 1 minute
measure: acceleration to measure sway
timeFrame: less than 1 minute
Other outcomes:
Locations:
city: Dallas
country: United States
facility: Parker University
state: Texas
Study officials:
References:
citation: Malaya CA, Haworth J, Pohlman KA, Smith DL. Immediate impact of extremity manipulation on dual task performance: a randomized, crossover clinical trial. Chiropr Man Therap. 2021 Feb 5;29(1):6. doi: 10.1186/s12998-021-00366-5.
Clinical trial NCT06023667: SMART-IBD App Trial
Official title: Self-Management Assistance for Recommended Treatement (SMART) App Randomized Control Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Inflammatory Bowel Diseases
IBD
Crohn Disease
Ulcerative Colitis
Keywords: IBD
Lead sponsor: Children's Hospital Medical Center, Cincinnati
Sponsor class: OTHER
First posted: 2023-09-05
Enrollment: 45
Sex: ALL
Minimum age (years): 13
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this trial is to test whether a smartphone app, SMART-IBD, is effective in improving medication adherence and self-management skills in adolescents with IBD. The investigators will conduct a randomized control trial to compare a sample of 15 youth (ages 13-17) with IBD using an app that has educational content and medication reminders to 15 youth in an attention control group. The length of the intervention will include one month of baseline adherence data collection, one month of intervention, and one month of post-treatment adherence data collection.


Eligibility criteria: Inclusion Criteria:

* Patient diagnosed with Crohn's disease, ulcerative colitis, or indeterminate colitis (collectively IBD)
* Prescribed at least one medication used to treat IBD, regardless of route of administration
* Access to internet or wi-fi or data plan and access to smartphone
* English fluency for patient and clinician

Exclusion Criteria:

* Diagnosis of pervasive developmental disorder in patient or caregiver as determined by medical chart review
* Diagnosis of serious mental illness (e.g., schizophrenia) in patient or caregiver as determined by medical chart review

Primary outcomes:
measure: Medication adherence
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cincinnati
country: United States
facility: Cincinnati Children's Hospital Medical Center
state: Ohio
Study officials:
References:
Clinical trial NCT03012867: Enteral Nutrition and Glucose Homeostasis
Official title: Effect of Different Enteral Nutrition Formulas on Glucose Homeostasis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Hyperglycemia Stress
Keywords: criticall illness
enteral nutrition
Lead sponsor: Medical University of Vienna
Sponsor class: OTHER
First posted: 2017-01-06
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Different enteral nutrition formulas are tested on their effect on glucose homeostasis in critically ill medical patients.

Detailed description: To assess whether enteral nutrition fomulas based either on fat or glucose influence glucose homeostasis differently in critically ill medical patients. All patients are admitted to a tertiary ICU and require mechanical ventilation.

Resting energy expenditure is assessed at baseline in the fasting state by indirect calorimetry. Total energy demand is calculated and patients are randomized to receive fat-based or glucose-based nutrition which is administered continously for 7 days. Indirect calorimetry is repeated on days 3 and 7 under continous nutrition. During the study period, various parameters of glucose homeostasis are assessed. Daily, there will be at least 3 measurements of blood glucose, more if the treating physician deems it necessary. Daily average glucose, daily glucose variability, overall area under the curve for glucose are calculated. Furthermore, energy intake by nutrition, medications (i.e. propofol), and glucose infusion, as well as substrate intake, and insulin demand per 24hrs are determined daily. Adverse effects such as episodes of hyper- or hypoglycemia, cholestasis, hypertriglyceridemia, diarrhea, vomiting, and the amount of gastric residual volume are noted.

Eligibility criteria: Inclusion Criteria:

* medical patient with need for mechanical ventilation
* FiO2 requirement \< 60%
* need for nutritional support

Exclusion Criteria:

* contraindications against nutritional therapy
* hemodynamic shock (lactate of ≥ 4 mmol/l)
* severe hypertriglyceridemia (≥ 450 mg/dl)
* contraindications against enteral nutrion (intestinal obstruction, disruption or severe bleeding of upper gastrointestinal tract)

Primary outcomes:
measure: average daily glucose
timeFrame: up to 7 days
Secondary outcomes:
measure: insulin demand per 24 hrs
timeFrame: up to 7 days
measure: glucose variability
timeFrame: up to 7 days
measure: nutrition-related side effects
timeFrame: 7 days
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: Medical University of Vienna
Study officials:
affiliation: Medical University of Vienna, Department of Internal Medicine III, Division of Gastroenterology and Hepatology
name: Christian Zauner, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02746640: Prospective Assessment Project About Cardiac Arrest Resuscitation
Official title: Prospective Assessment Project About Cardiac Arrest Resuscitation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiac Arrest
Lead sponsor: Insel Gruppe AG, University Hospital Bern
Sponsor class: OTHER
First posted: 2016-04-21
Enrollment: 148
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Every patient, for which the alarm button for a cardiopulmonary arrest gets triggered will be included and observate.

Brief summary: In case of a cardiac arrest it is very important to quickly provide high quality cardiopulmonary resuscitation (CPR). For reasons of patient safety the investigators want to assess the frequency, the quality and the outcome of cardiopulmonary resuscitations in the Inselspital Bern.


Eligibility criteria: Inclusion Criteria:

* Every patient for which the alarm button for a cardiopulmonary arrest gets triggered

Exclusion Criteria:

* None

Primary outcomes:
measure: Number of reanimation alarms during a time period of 1 year.
timeFrame: up to 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Berne
country: Switzerland
facility: University Hospital
Study officials:
References:
citation: Fuchs A, Kaser D, Theiler L, Greif R, Knapp J, Berger-Estilita J. Survival and long-term outcomes following in-hospital cardiac arrest in a Swiss university hospital: a prospective observational study. Scand J Trauma Resusc Emerg Med. 2021 Aug 11;29(1):115. doi: 10.1186/s13049-021-00931-0.