louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03497520: The Effect of Asymmetric Spinal Stabilization Exercise on Scoliosis
Official title: The Effect of Asymmetric Spinal Stabilization Exercise on Scoliosis
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Scoliosis Idiopathic
Keywords: surface EMG
cobb angle
exercise
Spinal Curvatures
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2018-04-13
Enrollment: 150
Sex: ALL
Minimum age (years): 8
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the effect of asymmetric spinal stabilization exercise on scoliosis

Detailed description: * Design: Prospective study
* Setting: hospital rehabilitation department
* Intervention: Participants are educated asymmetric spinal stabilization exercise along scoliosis curve patterns, including the location of apex and the direction of convexity. After performing asymmetric spinal stabilization exercise, participants are compared the main outcome measures.
* Main outcome measures: Cobb angle, Apical vertebral rotation in Adam's test, surface EMG, Scoliosis Research Society-22(SRS-22) quastionnaire

Eligibility criteria: Inclusion Criteria:

* who have idiopathic scoliosis, showing at Cobb's angle over 10 degrees on X-ray

Exclusion Criteria:

* Patients who underwent spinal surgery
* Patients with spinal scoliosis due to cerebral palsy, muscle paralysis, polio, congenital spinal abnormalities
* Patients observed with Cobb's angle less than 10 degrees, over 40 degrees
* Patients complaining of acute low back pain

Primary outcomes:
measure: cobb angle
timeFrame: through study completion, an average of 6 months
measure: Apical vertebral rotation
timeFrame: through study completion, an average of 1 year
measure: surface electromyography
timeFrame: through study completion, an average of 6 months
Secondary outcomes:
measure: Scoliosis Research Society-22(SRS-22) quastionnaire
timeFrame: through study completion, an average of 1 year
Other outcomes:
Locations:
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyeonggi-do
Study officials:
affiliation: Seoul National University Bundang Hospital
name: Jusuk Ryu, M.D. PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT06693674: A Study of Entresto in Tetralogy of Fallot (TOF) and Ebstein's Anomaly (EA)
Official title: Role of Sacubitril-Valsartan for Right Ventricular Reverse Remodeling in Adults With Tetralogy of Fallot and Ebstein's Anomaly: A Randomized Controlled Pilot Clinical Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Tetralogy of Fallot
Ebstein's Anomaly
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
Collaborators: name: National Heart, Lung, and Blood Institute (NHLBI)
First posted: 2024-11-18
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare changes in RV structure and function, biomarkers, and patient reported outcomes between TOF patients randomized to an ARNI vs placebo.


Eligibility criteria: Inclusion Criteria:

* TOF or EA
* Age 18 or Older

Exclusion Criteria:

* Stage IV chronic kidney disease defined as creatinine clearance \<30 ml/min
* Hyperkalemia defined as serum potassium \>5.2 mmol/l,
* Hypotension defined as systolic blood pressure \<100 mmHg,
* History of angioedema related to previous ACE or ARB therapy
* Patients diagnosed with diabetes using Aliskiren,
* Pregnancy.
* Drug Therapies

  * Amifostine
  * Droperidol
  * Dantrolene
  * CYP3A4 Inhibitors
  * Obinutuzumab
  * Aliskiren
  * Lithium
  * Sparsentan
  * ACE inhibitor
  * ARB
  * ARNI

Primary outcomes:
measure: Ventricular function
timeFrame: Baseline, Week 52
measure: Ventricular remodeling
timeFrame: Baseline, Week 52
measure: Change from baseline in Hs-Troponin
timeFrame: Baseline, Week 52
measure: Change from baseline in Galectin 3
timeFrame: Baseline, Week 52
measure: Change from baseline in Cystatin C
timeFrame: Baseline, Week 52
measure: Change in baseline in Soluble ST-2 (sST-2)
timeFrame: Baseline, Week 52
measure: Patient reported outcomes
timeFrame: Baseline, Week 52
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Alexander Egbe
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01104974: HIV Physician's Survey
Official title: Canadian Health Care Providers' Attitudes of Pregnancy, Fertility Care, and Assisted Reproductive Technologies for HIV-Positive Individuals
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: HIV
Keywords: HIV
HIV providers
Infectious Disease
HIV and pregnancy
Lead sponsor: Unity Health Toronto
Sponsor class: OTHER
First posted: 2010-04-16
Enrollment: 167
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: HIV Providers in Canada

Brief summary: This is a survey study to assess the variability in the current management of pregnancy, reproductive care and assisted reproductive technologies for HIV-positive individuals in Canada to estimate interest for further projects.


Eligibility criteria: Inclusion Criteria:

* any HIV health care provider

Exclusion Criteria:

* none

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00999674: The Effect of an Exercise Program on the Health-quality of Life (HQL) in Older Adults
Official title: The Effect of an Exercise Program on the Health-quality of Life (HQL) in Older
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: Exercise
Lead sponsor: Shahrekord University
Sponsor class: OTHER
First posted: 2009-10-22
Enrollment: 60
Sex: ALL
Minimum age (years): 55
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The present study aimed to investigate the effect of exercise program on health-quality of life (HQL) in older adults.

Detailed description: The questionnaire consisted of demographic data (such as age, gender, educational level, and employment) and the LEIPAD questionnaire used to measure HQL.

Eligibility criteria: Inclusion Criteria:

* sixty healthy adults volunteers
* over the age of 55 years

Exclusion Criteria:

* neurological disorder
* acute heart impairment
* unstable chronic illness
* severe musculo-skeletal impairment

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Health Ministry
name: M. Saeed Heydarnejad, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Heydarnejad S, Dehkordi AH. The effect of an exercise program on the health-quality of life in older adults. A randomized controlled trial. Dan Med Bull. 2010 Jan;57(1):A4113.
Clinical trial NCT05205174: Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury
Official title: Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: TBI (Traumatic Brain Injury)
Lead sponsor: University of Minnesota
Sponsor class: OTHER
First posted: 2022-01-25
Enrollment: 15
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Preliminary evaluation of depth electrode recording and novel algorithms to determine Cortical Spreading Depolarization's (CSD) following traumatic brain injury (TBI) requiring neurosurgical intervention.

Detailed description: During the standard of care External Ventricular Drain (EVD) placement, a depth electrode with minimal modification to the standard surgical procedure will be placed. This will allow electrocorticogram (ECoG) recordings. An ECoG will be reviewed by a study Neurosurgeon to understand the association between cortical spreading depression and pathological findings on imaging. The recordings help create a novel algorithm in order to detect CSD's. This may ultimately provide significant benefit to society through the diagnosis and treatment of secondary injury associated with traumatic brain injury.

Eligibility criteria: Inclusion Criteria:

* Patient recommended to undergo EVD placement for the monitoring and possible treatment of Intracranial pressure (ICP) after TBI

Exclusion Criteria:

* Contaminated scalp lacerations
* Known systemic infection
* Non-English speaking
* Fixed, uncorrectable coagulopathy

Primary outcomes:
measure: Detecting CSDs in TBI patients
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Minneapolis
country: United States
facility: Hennepin County Medical Center
state: Minnesota
Study officials:
affiliation: University of Minnesota
name: David Darrow, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06973174: Bacillus Cereus Invasive Infections in Preterm Neonates Hospitalized in French Hospitals
Official title: Bacillus Cereus Invasive Infections in Preterm Neonates Hospitalized in French Hospitals
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sepsis
Infections
Lead sponsor: Centre Hospitalier Universitaire de Nice
Sponsor class: OTHER
First posted: 2025-05-15
Enrollment: 40
Sex: ALL
Maximum age (years): 143
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The premature newborn included in the study were recruited from 14 NICU in 14 Tertiary Care center in France. This study is a national retrospective study

Brief summary: Background. Bacillus cereus group (Bc) comprises twenty-six closely related species of spore-forming environmental bacteria. Recently, increased sepsis and septic shock caused by Bc were reported in preterm neonates (PN), and the mortality rate can reach up to 30%. Using Whole Genome Sequencing (WGS) increasingly used to characterize Bc strains, The team aimed to determine an accurate identification to the species level of the strains involved in Bc invasive infections in preterm neonates in France and study their virulome profile.Methods. The team performed WGS for 40 neonate clinical strains responsible for invasive infections in PN. A screening of virulence genes was performed to characterize strains associated with poor prognosis. Clinical data were collected and all clinical and genomic findings were analyzed for risk factors for death.

"


Eligibility criteria: Inclusion Criteria:

* Premature newborn (i.e born before 37 last menstrual periods) with invasive infection caused by B. cereus (strains isolated from blood culture and cerebrsopinal fluid)

Exclusion Criteria:

* None

Primary outcomes:
measure: Mortality
timeFrame: 28 days after birth
Secondary outcomes:
Other outcomes:
Locations:
city: Nice
country: France
facility: CHU NICE
state: Alpes Maritimes
Study officials:
References:
Clinical trial NCT01760174: Comparing the Effect of TAP-catheter and Epidural Catheter on Postoperative Pain After Open Gynecologic Surgery
Official title: A Randomized Double Blind Trial Comparing the Effect of Transversus Abdominal Plane-catheter and Epidural Catheter on Postoperative Pain After Open Gynecologic Surgery
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Pain, Postoperative
Keywords: Transversus abdominis plane catheter
Lead sponsor: Aalborg University Hospital
Sponsor class: OTHER
Collaborators: name: Aarhus University Hospital
First posted: 2013-01-04
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study compares the effect on postoperative pain of bolus administration of ropivacaine in Transversus abdominis plane catheter and continuous bupivacain-infusion in epidural catheters following open gynecologic surgery.The study is double blind. The hypothesis is that the effect of the two modes of pain treatment are equal.

Detailed description: Patients for open gynecologic surgery will all receive both an epidural catheter and bilateral transversus abdominis plane (:TAP) catheters. After randomization in to two groups the patients receive either 1) intermittent boluses of ropivacaine in the TAP-catheters and isotonic potassium chloride-infusion i the epidural catheters or 2) intermittent isotonic potassium chloride-boluses i the TAP-catheters and bupivacain-infusion in the epidural catheters.

The investigators record pain-score and consumption of opioids in the first 24 hours postoperatively as well as thermoanalgesia at dermatome-levels th10-th12.

The investigators assume that the effect on postoperative pain after open gynecologic surgery is equal in the two groups.

Eligibility criteria: Inclusion Criteria:

* patients scheduled for open gynecologic surgery
* acceptance to participate

Exclusion Criteria:

* allergies to local analgetics
* daily use of strong opioids

Primary outcomes:
measure: Pain-score on numerical rating scale
timeFrame: 4 hours after first bolus in tranversus abdominis catheters
Secondary outcomes:
measure: Administration of opioids
timeFrame: The first 24 hours after surgery.
measure: Pain-score on numerical rating scale
timeFrame: 8 hours after first bolus in tranversus abdominis catheters
measure: Pain-score on numerical rating scale
timeFrame: 24 hours after first bolus in tranversus abdominis catheters
Other outcomes:
measure: Thermoanalgesia at dermatome-level th10-th12
timeFrame: 4 hours after first bolus in TAP-catherter
Locations:
city: Aalborg
country: Denmark
facility: Aalborg Hospital
state: Region Nord
Study officials:
affiliation: Aalborg University Hospital
name: Nils F Bjerregaard, M.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: Aalborg Sygehus
name: Bodil S Rasmussen, M.D. + PhD
role: STUDY_DIRECTOR
affiliation: Aarhus University Hospital
name: Lone Nikolajsen, M.D, PhD
role: STUDY_CHAIR
affiliation: Aarhus University Hospital
name: Thomas F Bendtsen, MD, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT04239274: Spectral Correlates of Impulsivity in Patients With Traumatic Brain Injury
Official title: Spectral Correlates of Impulsivity in Patients With Traumatic Brain Injury: A Study of the Effect of Transcranial Electrical Stimulation of the Ventrolateral Prefrontal Cortex on Response Inhibition
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Traumatic Brain Injury
Lead sponsor: Medical University of South Carolina
Sponsor class: OTHER
First posted: 2020-01-27
Enrollment: 0
Sex: ALL
Minimum age (years): 25
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Transcranial electrical stimulation (tES) is a non-invasive form of brain stimulation that has previously been to shown to have therapeutic potential in traumatic brain injury (TBI) patients. In this study, the study team will use a brain activity monitor (electroencephalogram, EEG) and a computer-based task to observe the effects of different forms of tES, like transcranial direct current stimulation (tDCS) and transcranial pulsed current stimulation (tPCS), on impulse control and sustained attention in people with TBI. Additionally, the study team will measure how much tDCS and tPCS affect the brain activity of a specific area of the brain associated with impulse control and attention. Problems with response inhibition have been shown to make rehabilitation more difficult for people with TBI. It also reduces social functioning and can also negatively affect job performance, which ultimately lead to a decreased quality of life. A better understanding of the effects of tES in TBI patients could be informative in finding out what its therapeutic potential is for this population.


Eligibility criteria: Inclusion Criteria:

* Subjects referred to the PI for management of TBI
* Subject is at least 3 months post-injury at the time of consent
* Ages 25-70

Exclusion Criteria:

* Subjects with the inability to consent for themselves
* Subjects with body habitus that does not allow the EEG cap to be properly placed
* Presence of scalp injury or disease
* Allergic reaction to topical lidocaine jelly
* Prior intracranial surgery or skull-fracture over VLPFC
* Presence of hemorrhage on intracranial imaging
* Prior brain radiotherapy
* Prior history of intracranial tumor, intracranial infection, or cerebrovascular malformation
* Subjects with the inability to see and read from a computer screen
* History of any form of seizures prior to TBI or within 6 months of study participation
* Pregnancy

Primary outcomes:
measure: Average Reaction Time During Stop Signal Task
timeFrame: Throughout study (1 hour)
measure: EEG power in all frequency bands
timeFrame: Baseline and immediately post Stimulation
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Medical University of South Carolina
name: Nathan Rowland, MD,PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02924974: Spinal Morphine in Robotic Assisted Radical Prostatectomy
Official title: Spinal Morphine in Robotic Assisted Radical Prostatectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Morphine
Injections, Spinal
Prostatectomy
Patient Satisfaction
Lead sponsor: Maasstad Hospital
Sponsor class: OTHER
First posted: 2016-10-05
Enrollment: 160
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will investigate if a single shot of spinal morphine will increase patient satisfaction when compared to intravenous morphine in Robot-Assisted Radical Prostatectomy

Detailed description: This study is a randomized controlled trial. It will randomize 160 patients who are scheduled for Robot-Assisted Radical Prostatectomy. The intervention group will receive a single spinal injection of a bupivacaine (12,5 mg)/morphine(300 mcg) mixture. Controlgroup will receive a subcutaneous injection of lidocaïne for placebo purposes and an intravenous loading dose of morphine at the end of surgery.

Both groups will receive general anesthesia during surgery in a standardized fashion.

After the surgery, both groups will receive a Patient-Controlled Analgesia pump for post-operative pain control.

Primary outcome is patient satisfaction as measured by the Quality-of-Recovery-15 questionnaire. This questionnaire will be taken at baseline, day 2 and 1 week after surgery.

Secundary outcomes are morphine use per PCA, duration of hospital stay, side-effects and ease of surgery.

Eligibility criteria: Inclusion Criteria:

* Scheduled for Robot-Assisted Radical Prostatectomy

Exclusion Criteria:

* Contra-indications to spinal anesthesia (severe aortic stenosis, coagulation disorders)
* Contra-indications to study medication (local anesthetics, morphine, paracetamol, metamizol)
* Conversion to an open procedure
* Post-operative ICU-admission

Primary outcomes:
measure: Patient satisfaction
timeFrame: day 1
Secondary outcomes:
Other outcomes:
Locations:
city: Rotterdam
country: Netherlands
facility: Maasstad Hospital
Study officials:
affiliation: Maasstad Ziekenhuis
name: Seppe Koopman, MD, PhD
role: STUDY_CHAIR
affiliation: Maasstad Ziekenhuis
name: Aart Jan W Teunissen, MD
role: STUDY_CHAIR
affiliation: Maasstad Ziekenhuis
name: Mark V Koning, MD, DESA
role: PRINCIPAL_INVESTIGATOR
References:
citation: Koning MV, de Vlieger R, Teunissen AJW, Gan M, Ruijgrok EJ, de Graaff JC, Koopman JSHA, Stolker RJ. The effect of intrathecal bupivacaine/morphine on quality of recovery in robot-assisted radical prostatectomy: a randomised controlled trial. Anaesthesia. 2020 May;75(5):599-608. doi: 10.1111/anae.14922. Epub 2019 Dec 17.
Clinical trial NCT06165874: [68Ga]Ga-NOTA-RW102 PET Imaging in the Diagnosis of PD-L1-expressing Lung Cancer
Official title: [68Ga]Ga-NOTA-RW102 PET Imaging in the Diagnosis of PD-L1-expressing Lung Cancer
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Non-small Cell Lung Cancer
Keywords: non-small cell lung cancer
Positron-Emission Tomography
Lead sponsor: Huashan Hospital
Sponsor class: OTHER
First posted: 2023-12-12
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The aim of this study was to establish and optimize the imaging method of \[68Ga\]Ga-NOTA-RW102, as well as its physiological and pathological distribution characteristics, on the basis of which the diagnostic efficacy of the above imaging agent was evaluated in patients with non-small cell lung cancer


Eligibility criteria: Inclusion Criteria:

* Patients with PD-L1-positive non-small cell lung cancer

  1. Age between 18 and 65 years old, gender is not limited.
  2. Patients with CT findings that can be occupied on the lung with a diameter greater than 1cm or more who have not undergone surgery.
  3. Lung cancer patients with a clinical diagnosis of positive PD-L1 expression;
  4. Written informed consent must be signed by the subject or his/her legal guardian or caregiver.
  5. Willingness and ability to cooperate with all programs of this study.

Exclusion Criteria:

* Subjects meeting any of the following criteria will be excluded from the study:

  1. Severe hepatic and renal insufficiency;
  2. Targeted therapy prior to radiotherapy or PET/CT scan. PD-L1 expression in existing lesions was assessed by immunohistochemistry using antibody clone 22C3. Renal function: serum creatinine less than or equal to the upper limit of the normal range;
  3. Liver function: bilirubin, AST(SGOT)/ALT(SGPT) less than or equal to the upper limit of the normal range.
  4. History of serious surgery in the last month.
  5. Those who have participated in other clinical trials during the same period.

Primary outcomes:
measure: Calculation and comparison of [68Ga]Ga-NOTA-RW102 radioactivity concentrations in focal and non-focal tissues
timeFrame: 90mins from time of injection
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Huashan Hospital
Study officials:
affiliation: Huashan Hospital
name: Fang Xie, PhD
role: PRINCIPAL_INVESTIGATOR
References: