louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06526520: Relaxin Measurement in Different Endometrial Preparation Approaches for Frozen Embryo Transfer
Official title: Relaxin Measurement in Different Endometrial Preparation Approaches for Frozen Embryo Transfer
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Frozen Embryo Transfer
Keywords: frozen embryo transfer
hormonal replacement cycle
natural cycle
Relaxin
Lead sponsor: ART Fertility Clinics LLC
Sponsor class: OTHER
First posted: 2024-07-29
Enrollment: 5
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: - healthy volunteers with regular cycles

Brief summary: To investigate the levels of Relaxin in different types of endometrial preparation for a frozen embryo transfer cycle. Up to now it is unclear, whether ovulation with a functional corpus luteum (CL) will be present in a natural proliferative phase (NPP) endometrial preparation approach.

Detailed description: The last years have seen a distinct shift from fresh (fresh ET) to frozen embryo transfer (FET) cycles. Furthermore it became obvious, that the endometrial preparation approach has a significant impact on the course of the pregnancy and that a HRT endometrial preparation approach is associated with a higher risk for bleeding and miscarriages in early pregnancy and for the development of pregnancy induced hypertension and pre-eclampsia later in pregnancy.

These conditions are attributed to the absence of a CL in the HRT approach. Lately a new endometrial preparation approach is discussed and performed, the so called natural proliferative phase protocol, in which the follicle growth is monitored and when the lining is deemed to have a sufficient thickness and the triple lining pattern, exogeneous progesterone is started to induce secretory transformation before spontaneous ovulation. Despite some studies showing, that exogeneous progesterone administration might induce ovulation, it is not clear whether there will be a CL, producing Relaxin, in the NPP approach.

Eligibility criteria: Inclusion Criteria:

* regular menstrual cycles

Exclusion Criteria:

* abnormal findings of the ovaries (e.g endometriosis)
* Intake of any hormones within 3 months of study start
* desire to become pregnant

Primary outcomes:
measure: Relaxin measurement
timeFrame: 4 to 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Abu Dhabi
country: United Arab Emirates
facility: ART Fertiltiy Clinic
Study officials:
affiliation: ART Fertility Clinic
name: Barbara Lawrenz, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01650220: Cardiovascular Risk Markers in Veterans With Post Traumatic Stress Disorder
Official title: Cardiovascular Risk Markers in Veterans With PTSD
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Cardiovascular Disease
Post Traumatic Stress Disorder
Lead sponsor: INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Sponsor class: OTHER
Collaborators: name: U.S. Army Medical Research and Development Command
First posted: 2012-07-26
Enrollment: 13
Sex: ALL
Minimum age (years): 28
Maximum age (years): 38
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: OIF and OEF veterans within the VASDHS, who are between 28 and 38 years of age inclusively

Brief summary: This is an observational study designed to determine whether veterans with PTSD have a higher risk of heart disease than those without PTSD. Cardiovascular risk will be assessed by interview and review of medical records, carotid artery ultrasound, and blood tests measuring markers of inflammation. Study participation is approximately 6 months. The eligible study population is veterans of Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF), age 28 through 38 years.


Eligibility criteria: Inclusion Criteria:

* OEF/OIF veterans at the VASDHS
* Between 28 and 38 years of age
* Willing to complete structured diagnostic interview for PTSD, CIMT ultrasound and blood test
* Willing to have a review of their medical records
* Able to give informed consent
* Have a negative urine pregnancy test, if a woman of child-bearing age

Exclusion Criteria:

* Do not meet inclusion criteria
* History of schizophrenia, other neurocognitive illness (including severe TBI by INTRuST criteria)) or active alcohol and/or drug abuse determined by chart review, interview or AUDIT-C score
* Inability to complete study tests within 18 months of study start
* Pregnancy

Primary outcomes:
measure: Recruitment methods feasibility
timeFrame: 12 months
measure: Completion of structured diagnostic interview within 2hrs.
timeFrame: 12 months
measure: Ability to schedule Carotid Intima-Media Thickness (CIMT) ultrasound in the Vascular Lab at VA San Diego Healthcare Systems, within 4 months of enrollment
timeFrame: 18months
measure: Time from CIMT completion to completion of clinical read.
timeFrame: 18months
measure: Completion of serum lab measurements.
timeFrame: 18months
Secondary outcomes:
measure: Carotid Intimal Medial Thickness (CIMT) measurement
timeFrame: Within 4 months of subject recruitment
measure: Cardiovascular Disease Biomarkers
timeFrame: Within 6 months of subject recruitment
Other outcomes:
Locations:
city: San Diego
country: United States
facility: VASDHS
state: California
Study officials:
affiliation: University of California, San Diego
name: Vibha Bhatnagar, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00355420: Evaluation of the Change in Length of the Leg in Children After Treatment of Femur Fractures.
Official title: Evaluation of the Change in Length of the Femur and Tibia in Children After Treatment of Femur Fractures With External Fixators, Plaster of Paris or Internal Fixation
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Fractures
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2006-07-21
Enrollment: 0
Sex: ALL
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: children that sufferinf from LLD

Brief summary: Femur fractures are a common injury in the Pediatric population. Despite their high incidence little do we know about the long term implications on the bones' length. Our main goal is to clarify this obscure issue by assessing the femoral and tibial length as determined by the fractures, measuring techniques and treatment modalities


Eligibility criteria: Inclusion Criteria:

* Males between the ages 0-16.
* Females between the ages 0-14.
* Signed Informed consent

Exclusion Criteria:

* A refusal by the patient or his legal guardian to continue the follow-up with the
* Pediatric Orthopedic clinic, or to have the CT scanograms.
* Patients with severe contractures in the lower extremities
* Patients with multiple lower extremity fractures
* Pregnancy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Hadassah Medical Organization
Study officials:
affiliation: Hadassah Medical Organization
name: Ron Lamdan, Dr.
role: PRINCIPAL_INVESTIGATOR
affiliation: Hadassah Medical Organization
name: Shlomo Porat, Prof.
role: STUDY_CHAIR
affiliation: Hadassah Medical Organization
name: Naum Simanovski, Dr.
role: STUDY_DIRECTOR
References:
Clinical trial NCT00888420: The Application of Performance Improvement Principles to the Patient Throughput Process in an Adult Outpatient Pain Treatment Clinic
Official title: The Application of Performance Improvement Principles to the Patient Throughput Process in an Adult Outpatient Pain Treatment Clinic
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Pain
Keywords: Chronic Pain
Lead sponsor: University of Alabama at Birmingham
Sponsor class: OTHER
First posted: 2009-04-27
Enrollment: 1221
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Outpatient pain clinic patients

Brief summary: This study is undertaken to assess and improve the existing patient flow, or so-called throughput process, in an adult outpatient pain treatment clinic.


Eligibility criteria: Inclusion Criteria:

* 19-100 years of age.
* patient presenting to the UAB Highlands Pain Treatment Clinic for initial evaluation and treatment or subsequent follow-up evaluation and treatment.

Exclusion Criteria:

* \<19 or \>100 years of age
* a current prisoner

Primary outcomes:
measure: the total time patients spend to receive chronic pain treatment
timeFrame: prospective
Secondary outcomes:
measure: The total time health care providers must devote to delivering chronic pain treatment
timeFrame: prospective
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: UAB Highlands Pain Treatment Clinic
state: Alabama
Study officials:
affiliation: UAB Department of Anesthesiology
name: Thomas R. Vetter, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04731220: A Questionnaire Survey for Biliary Tract Cancers
Official title: A Questionnaire Survey Study for Establishment of Surveillance and Prevention Through the Analysis of Epidemiologic Risk Factors in Patients With Biliary Tract Cancers
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Biliary Tract Cancer
Lead sponsor: Kyungpook National University Chilgok Hospital
Sponsor class: OTHER
Collaborators: name: Kyungpook National University Hospital
name: Pusan National University Hospital
name: Pusan National University Yangsan Hospital
First posted: 2021-01-29
Enrollment: 12000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study population should be defined in advance, stating eligibility criteria.

Brief summary: The purpose of this study is:

* To evaluate risk factors for cancers of the biliary tract by registering new patients and their counterparts in a multi-center program
* Development of programs by creating a multi-center biliary tract cancer registration system


Eligibility criteria: Inclusion Criteria:

* Study population :

  * Newly diagnosis of biliary tract cancers - Pathological or Radiological or other clinical diagnosis of biliary tract cancers
  * Informed consent
* Control :

  * with no previous cancer diagnosis
  * Informed consent

Exclusion Criteria:

* Previous diagnosis of bile duct cancer with resection operation, endoscopic resection, chemotherapy or radiation therapy
* Prior diagnosis of other cancer in 5 years or ongoing cancer treatment
* Patients' refusal

Primary outcomes:
measure: Number and percentage of cases and controls who complete each part of the study
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Daegu
country: Korea, Republic of
facility: Kyungpook National University Chilgok Hospital
Study officials:
References:
Clinical trial NCT01075620: Comparison of Nonposterior- and Posterior-Stabilized Mobile-Bearing Total Knee Arthroplasty
Official title: Comparison of Nonposterior- and Posterior-Stabilized Mobile-Bearing Total Knee Arthroplasty A Prospective, Randomized Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Osteoarthritis
Keywords: rotating platform
posterior stabilized
non-posterior stabilized
Lead sponsor: Ewha Womans University
Sponsor class: OTHER
First posted: 2010-02-25
Enrollment: 126
Sex: ALL
Minimum age (years): 30
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine if there are any clinical or radiographic differences in non-posterior stabilized rotating mobile bearing design versus a posterior stabilized rotating mobile bearing designs.

Detailed description: Out comes measures were to determine

1. whether the knee and function scores and the radiographic results of the knees with a PFC Sigma RP knee prosthesis would be better than those with an LCS RP prosthesis.
2. whether the patients with a PFC RP knee prosthesis would have a better range of knee motion than those with an LCS RP prosthesis.
3. whether patient satisfaction and preference would be better in the patients having a PFC Sigma RP knee prosthesis than those of patients having an LCS RP knee prosthesis
4. whether complication rate would be less in the knees with a PFC sigma RP knee prosthesis than in the knees with an LCS RP prosthesis.

Eligibility criteria: Inclusion Criteria:

* End-stage osteoarthritis of the knee joint requiring total knee arthroplasty with bilateral disease

Exclusion Criteria:

* Inflammatory disease
* patient with other Lower extremity disease which may affect functional outcome
* Neurologic disease effecting patients lower extremity
* Revision surgery
* Patient not medically cleared for bilateral surgery

Primary outcomes:
measure: Knee Society knee score
timeFrame: at 3 months, 1 year, than annually
Secondary outcomes:
measure: Range of motion
timeFrame: at 3 months, 1 year, than annually
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Ewha Womans University Mokdong Hospital
Study officials:
affiliation: Ewha Womans University Mokdong Hospital
name: Yoowang Choi, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT07017920: Vitamin D and Hypertensive Disorders of Pregnancy
Official title: The Relationship Among Vitamin Deficiency/Insufficiency, Vitamin Supplementation, and Hypertensive Disorders of Pregnancy
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Hypertensive Disorders of Pregnancy
Keywords: vitamin D
Lead sponsor: TriHealth Inc.
Sponsor class: OTHER
First posted: 2025-06-12
Enrollment: 594
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to further investigate the association between vitamin D deficiency/insufficiency and hypertensive disorders of pregnancy by studying the impact of screening for vitamin D deficiency and supplementation when low levels of vitamin D are detected. Screening for vitamin D deficiency (less than 20 ng/mL) and insufficiency (less than 30 ng/mL) may determine the need for additional supplementation, as most prenatal vitamins only contain 400 IU of vitamin D. The rates of hypertensive disorders of pregnancy amongst patients who received supplementation and maintained adequate vitamin D levels will be followed.


Eligibility criteria: Inclusion Criteria:

* Pregnant women
* 18-45 years old
* Receiving care at outpatient OB office of TriHealth's Women's Services Comprehensive OB-GYN Team with a plan to deliver at Bethesda North Hospital

Exclusion Criteria:

* Non-English speaking
* Unable to provide consent to research study participation
* Diagnosis of preexisting renal disease
* Diagnoses of preexisting chronic hypertension
* Diagnosis of cardiovascular diseases
* Diagnosis of conditions limiting fat absorption
* Diagnosis of sarcoidosis

Primary outcomes:
measure: Hypertensive disorders of pregnancy
timeFrame: During pregnancy, up to 9 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02948920: Single Bolus Intravenous Ephedrine Attenuates Reduction of Core Body Temperature in Patients Undergoing Spinal Anesthesia for Arthroscopic Knee and Ankle Surgery
Official title: Single Bolus Intravenous Ephedrine Attenuates Reduction of Core Body Temperature in Patients Undergoing Spinal Anesthesia for Arthroscopic Knee and Ankle Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Body Temperature Changes
Keywords: ephedrine
core temperature
tympanic temperature
heat loss
spinal anesthesia
neuraxial
hypothermia
shivering
Lead sponsor: Ramathibodi Hospital
Sponsor class: OTHER
First posted: 2016-10-31
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: A prospective double-blinded randomized controlled study to determine efficacy of ephedrine in preserving core temperature in patients under neuraxial spinal anesthesia for knee and ankle arthroscopic surgery.

Detailed description: To determine the effect of ephedrine on preserving core temperature (tympanic) when given at finishing of local anesthetic administration for spinal neuraxial anesthesia comparing to normal saline (120 minutes period)

Eligibility criteria: Inclusion Criteria:

* Patient undergoing knee or ankle arthroscopic surgery under spinal block at department of orthopaedic Ramathibodi Hospital
* BMI 17-30 kg/m2
* ASA physical status 1-3
* Age 18-70
* Last oral intake more than 6 hours (2 hours for water)
* Consent form acquired

Exclusion Criteria:

* Patient who are contraindicated for spinal block
* Anesthesia level higher than T4 or lower than T10
* Tympanic temperature more than 37.5 or less than 35.5 degrees Celsius
* Otitis or other ear infection
* Patients who receive alpha adrenergic blocker or beta adrenergic blocker
* Initial blood pressure presenting in operating theater 140 90 mmHg repeat after rest 5 minutes
* Patient refusal

Primary outcomes:
measure: Tympanic temperature
timeFrame: 120 minutes
Secondary outcomes:
measure: Blood pressure
timeFrame: 120 minutes
measure: Shivering
timeFrame: 120 minutes
Other outcomes:
Locations:
city: Bankok
country: Thailand
facility: Department of Anesthesiology, Ramathibodi Hospital
state: Bangkok
Study officials:
affiliation: Department of Anesthesiology, Ramathibodi Hospital
name: Thanist Pravitharangul, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Thanist Pravitharangul, Wirakorn Koopinpaitoon, Rungruedee Kraisen, Rojnarin Komonhirun. Ephedrine and propofol for induction of general anesthesia can decrease intraoperative hypothermia in patients undergoing plastic and breast surgery: a randomized, controlled trial. Asian Biomedicine Vol. 9 No. 3 June 2015; 379 - 385
Clinical trial NCT03775720: Disclosure of Genetic Risk for Salt Sensitivity
Official title: Does Disclosing Genetic Risk to Salt Sensitivity Increase Compliance to Personalised Dietary Recommendations?
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Salt-sensitive Hypertension
Lead sponsor: St Mary's University College
Sponsor class: OTHER
First posted: 2018-12-14
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The global burden of cardiovascular disease (CVD) has decreased over the past 10 years. Nevertheless, the disease still kills one in three people. Hypertension is one of the leading causes of cardiovascular disease, with salt in the diet being a main contributor. Depending on an individual's DNA, participants may or may not be salt sensitive. Genotyping individuals for variants in a salt sensitivity gene (SLC4A5) may identify salt sensitive individuals which may benefit from a personalised dietary advice to reduce salt intake. Adherence to such advice can then be assessed which may aid in prevention of hypertension and CVD.

Detailed description: Salt sensitivity is a key risk factor for hypertension. However, population decrease in salt intake is less than optimal. Research suggests genetics-based personalised nutrition can positively impact health behaviours aiding in the prevention of chronic disease development. However, the effects of communicating such information are unclear. The aims of this study will be to analyse the impact of communicating genetic susceptibility to salt sensitivity on salt intake by assessing dietary salt intake before and after disclosure of genetic risk for hypertension according to the polymorphism in the SLC4A5. Participants will be normotensive, aged 18-35 years. All individuals will receive genetics-based personalised nutritional information. Participants displaying the risk genotype (AA + AC) will be advised to decrease salt intake to less than 4g/d and non-risk will be advised to adhere to government recommendations (6g/d). Dietary recall (24hrs) and 24-hour urine collection will be collected at baseline and four-weeks post-intervention to assess salt intake and excretion.

Eligibility criteria: Inclusion Criteria:

* healthy males and females, aged 18-35

Exclusion Criteria:

* pregnant, CVD events (Angina, myocardial infarction, heart failure) or stage 2, hypertension, a BMI ≥30kg/m2, or experiencing mental anguish.

Primary outcomes:
measure: Dietary salt intake
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: