Clinical trial NCT00345943: An fMRI Study of Self-regulation in Adolescents With Bulimia Nervosa
Official title: An fMRI Study of Self-regulation in Adolescents With Bulimia Nervosa
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Eating Disorders
Keywords: Eating Disorders
Bulimia Nervosa
Bulimia
fMRI
Magnetic Resonance Imaging
Lead sponsor: New York State Psychiatric Institute
Sponsor class: OTHER
Collaborators: name: National Institute of Mental Health (NIMH)
First posted: 2006-06-29
Enrollment: 71
Sex: FEMALE
Minimum age (years): 12
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adolescents (ages 12-17 years) with bulimia nervosa and age, gender, and weight-matched controls

Brief summary: The aim of this project is to use both multimodal MRI and behavioral measures to investigate how changes in frontostriatal neural systems contribute to the development and persistence of Bulimia Nervosa (BN). Findings from this study will have wide-ranging importance for our understanding of the development and treatment of BN.

Detailed description: Patients with Bulimia Nervosa (BN) have difficulty regulating impulsive behaviors as suggested by their binge-eating and purging, as well as the high incidence of drug abuse and shoplifting in this population. Understanding dysfunction in the frontostriatal circuitry that mediates self-regulatory control processes will aid development of new therapeutics for the impulsivity associated with BN. We are conducting a longitudinal study to better understand the development and persistence of BN.

Participation in this study includes 4 sections: Neuropsychological Tests, Diagnostic interviews, Pregnancy Test, and MRI scan. All efforts are made to coordinate procedures into one day, and they require between 4 and 5 hours of the participant's time. The option of splitting participation into two study days is also offered for participants who find it more convenient. Participants are compensated with $100 in the form of a check, which is mailed to their home address. Participants will be invited back for follow-up visits.

Eligibility criteria: Inclusion Criteria:

* Current or prior DSM IV diagnosis of Bulimia Nervosa or Sub-threshold Bulimia Nervosa (those who meet all DSM-IV criteria for BN, but engage in subjective binge-eating episodes and binge/purge at a frequency of at least once per week for 3 months, whereas meeting full DSM-IV criteria for BN requires binge eating and purging twice per week for 3 months)
* Major Depression
* For control adolescents, no current or past history of an eating disorder

Exclusion Criteria:

* Ferromagnetic implants (e.g., pacemaker)
* Metal braces or retainers
* IQ less than 80
* Any other current major Axis I disorder, other than major depressive disorder (MDD)
* History of concussion, seizure disorder, or other neurological illness
* Claustrophobia
* Pregnant

Primary outcomes:
measure: Magnetic Resonance Imaging Scans
timeFrame: Baseline
Secondary outcomes:
measure: Conners Continuous Performance Test-II (CPT-II)
timeFrame: Baseline
measure: Stroop Word-Color Interference
timeFrame: Baseline
measure: Weather Prediction Task
timeFrame: Baseline
Other outcomes:
Locations:
city: New York
country: United States
facility: New York State Psychiatric Institute at Columbia University Medical Center
state: New York
Study officials:
affiliation: Columbia University
name: Rachel Marsh, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Berner LA, Wang Z, Stefan M, Lee S, Huo Z, Cyr M, Marsh R. Subcortical Shape Abnormalities in Bulimia Nervosa. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Dec;4(12):1070-1079. doi: 10.1016/j.bpsc.2018.12.011. Epub 2019 Jan 4.
citation: Cyr M, Wang Z, Tau GZ, Zhao G, Friedl E, Stefan M, Terranova K, Marsh R. Reward-Based Spatial Learning in Teens With Bulimia Nervosa. J Am Acad Child Adolesc Psychiatry. 2016 Nov;55(11):962-971.e3. doi: 10.1016/j.jaac.2016.07.778. Epub 2016 Sep 8.
citation: Marsh R, Maia TV, Peterson BS. Functional disturbances within frontostriatal circuits across multiple childhood psychopathologies. Am J Psychiatry. 2009 Jun;166(6):664-74. doi: 10.1176/appi.ajp.2009.08091354. Epub 2009 May 15.