Clinical trial NCT06825962: The Effect of Hydration on Postprandial Metabolic Responses
Official title: The Effect of Hydration on Postprandial Metabolic Responses
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Glycaemia
Keywords: Hydration
Dehydration
Hypohydration
Glycemia
Glycaemia
Glucose control
Lead sponsor: Loughborough University
Sponsor class: OTHER
Collaborators: name: National Institute for Health Research Leicester Biomedical Research Centre
First posted: 2025-02-13
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Randomised, crossover design
Primary purpose: BASIC_SCIENCE

Brief summary: Certain populations, such as industrial workers and endurance athletes are particularly susceptible to dehydration due to exposure to heat for long periods of time causing evaporative water loss via sweating. The physical and cognitive decrements associated with dehydration have been widely researched, however the effect of dehydration on metabolism is lesser known. As climate change is causing temperatures to rise, and metabolic diseases such as type 2 diabetes are more common, the effect of dehydration on metabolism, specifically glycemic response to meals, needs to be established for future recommendations in clinical, environmental and athletic settings.

Therefore, the aim of this study is to investigate the effect of acute exercise-induced dehydration on subsequent metabolic responses to feeding (i.e. glycaemia and insulinaemia).


Eligibility criteria: Inclusion Criteria:

* Male or female
* Generally fit and healthy
* Participate in endurance or intermittent exercise at least 3 times a week or minimum of 150 minutes moderate intensity activity per week

Exclusion Criteria:

* \< 18 or \> 45
* Any health condition that may affect study outcomes (e.g., endocrine/liver/renal/cardiovascular disease)
* Any morbidity that affects ability to cycle
* Smoker or vaper

Primary outcomes:
measure: Plasma glucose
timeFrame: 6 hours
Secondary outcomes:
measure: Plasma insulin
timeFrame: 6 hours
measure: Plasma osmolality
timeFrame: 6 hours
measure: Plasma volume change
timeFrame: 6 hours
measure: Urine volume
timeFrame: 6 hours
measure: Body mass
timeFrame: 6 hours
measure: Urine specific gravity/osmolality
timeFrame: 6 hours
measure: Thirst sensation
timeFrame: 6 hours
measure: Hunger sensation
timeFrame: 6 hours
measure: Fullness sensation
timeFrame: 6 hours
measure: Core body temperature
timeFrame: 6 hours
measure: Blood pressure
timeFrame: 6 hours
Other outcomes:
measure: N-back task for working memory (cognitive function)
timeFrame: 3 hours
measure: Go/no-go task for response inhibition (cognitive function)
timeFrame: 3 hours
measure: Oculomotor function antisaccade task
timeFrame: 3 hours
measure: Oculomotor function prosaccade task
timeFrame: 3 hours
measure: Oculomotor function smooth pursuit task
timeFrame: 3 hours
Locations:
city: Loughborough
country: United Kingdom
facility: Loughborough University
state: Leicestershire
Study officials:
References: