Clinical trial NCT06611774: Metabolic Syndrome in Patients with Knee Osteoarthritis
Official title: Metabolic Syndrome in Patients with Knee Osteoarthritis
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis
Metabolic Syndrome
Keywords: knee osteoarthritis
metabolic syndrome
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2024-09-25
Enrollment: 174
Sex: ALL
Minimum age (years): 30
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients admitted in assiut university hospitals and presenting to its clinics

Brief summary: Study the prevalence of metabolic syndrome in patients with knee osteoarthritis and conclude the relationship between metabolic syndrome and the severity of knee osteoarthritis

Detailed description: Osteoarthritis is one of the most common clinical conditions causing severe chronic and restrictive disability, especially in elderly people.

Of those aged 60 years and older, 10% of men and 13% of women had symptomatic knee OA . As the population ages and the prevalence of obesity and overweight generaly rises , the percentage of persons affected with symptomatic knee OA will likely increase.

The clinical manifestations in patients are joint pain, stiffness, and functional limitation .

Among all body joints; knee joint is the most commonly affected joint with osteoarthritis and accounts almost for four-fifth of the osteoarthritis burden worldwide .

Epidemiological research has shown an encouraging relationship between OA and metabolic syndrome , MetS include hypertension, dyslipidemia, hyperglycemia, and obesity .Recently, metabolic OA has been nominated as the fifth component of MetS .

Studies reported that adipokines may contribute to the development of osteoarthritis (OA) by increasing inflammatory cytokines and growth factors, modifying insulin sensitivity, and triggering processes that break down cartilage.

Studies also reported that hypertension can be linked to osteoarthritis through astherosclerosis which cause subchondral bone ischemia accelerating OA progression.

Furthermore, researches have linked glucose levels to knee osteoarthritis , supporting the possibility of pathophysiological mechanisms such oxidative stress in the chondrocytes and Cartilage-associated production of advanced glycation end products (AGEs) .

Eligibility criteria: Inclusion

1. Both males and female .
2. Age between 30 and 70 years old.
3. Patient fulfill the criteria of knee osteoarthritis .

Exclusion Criteria:

1. Patients known to have rheumatological disease .
2. Patients with meniscal or cruciate ligament injury .
3. Patients with previous knee surgery .

Primary outcomes:
measure: Metabolic syndrome in patients with knee osteoarthritis
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Maddah S, Mahdizadeh J. Association of Metabolic Syndrome and Its Components with Knee Osteoarthritis. Acta Med Iran. 2015 Dec;53(12):743-8.
citation: Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010 Aug;26(3):355-69. doi: 10.1016/j.cger.2010.03.001.
citation: Goldring SR, Goldring MB. Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk. Nat Rev Rheumatol. 2016 Nov;12(11):632-644. doi: 10.1038/nrrheum.2016.148. Epub 2016 Sep 22.
citation: Xie DX, Wei J, Zeng C, Yang T, Li H, Wang YL, Long HZ, Wu ZY, Qian YX, Li KH, Lei GH. Association between metabolic syndrome and knee osteoarthritis: a cross-sectional study. BMC Musculoskelet Disord. 2017 Dec 16;18(1):533. doi: 10.1186/s12891-017-1890-9.
citation: Courties A, Sellam J. Osteoarthritis and type 2 diabetes mellitus: What are the links? Diabetes Res Clin Pract. 2016 Dec;122:198-206. doi: 10.1016/j.diabres.2016.10.021. Epub 2016 Nov 5.
citation: Tu C, He J, Wu B, Wang W, Li Z. An extensive review regarding the adipokines in the pathogenesis and progression of osteoarthritis. Cytokine. 2019 Jan;113:1-12. doi: 10.1016/j.cyto.2018.06.019. Epub 2018 Jun 28.