louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05046691: Mindfulness, Compassion and Self-compassion
Official title: Mindfulness, Compassion and Self-compassion
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mental Health Issue
Keywords: mindfulness
teacher mental health
compassion
self-compassion
common humanity
mindfulness-based intervention for teachers
Lead sponsor: The University of Hong Kong
Sponsor class: OTHER
First posted: 2021-09-16
Enrollment: 328
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Teachers in Hong Kong are susceptible to professional stress and its associated psychosomatic illnesses. To enhance teachers' well-being, mindfulness training is conducted in local schools. The present study is a randomized controlled trial to explore 1) the relationship between mindfulness, common humanity, self-compassion, compassion, and well-being of school teachers; 2) whether mindfulness and common humanity are the antecedents of self-compassion and compassion; 3) the conditions under which compassion and self-compassion are highly correlated. Participants will be randomized to either intervention (8-week .b Foundations course) or waiting-list control condition. They will complete an online survey before (baseline), after (post-intervention), and two-months (follow-up) after the intervention.


Eligibility criteria: Inclusion Criteria:

* Aged 18 years old or above
* Working in local schools or education institutions
* Willing to participate in mindfulness training voluntarily

Exclusion Criteria:

* Experiencing severe or unstable mental health condition currently
* Completed 8-week mindfulness training previously
* Unwilling to go by random assignment

Primary outcomes:
measure: Change in General Health
timeFrame: Baseline, Immediately after intervention, Two-months after intervention
measure: Change in Stress
timeFrame: Baseline, Immediately after intervention, Two-months after intervention
Secondary outcomes:
measure: Change in Positive affect
timeFrame: Baseline, Immediately after intervention, Two-months after intervention
measure: Change in Negative affect
timeFrame: Baseline, Immediately after intervention, Two-months after intervention
measure: Change in Compassion
timeFrame: Baseline, Immediately after intervention, Two-months after intervention
measure: Change in Self-compassion
timeFrame: Baseline, Immediately after intervention, Two-months after intervention
measure: Change in Common humanity
timeFrame: Baseline, Immediately after intervention, Two-months after intervention
measure: Change in Mindfulness
timeFrame: Baseline, Immediately after intervention, Two-months after intervention
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: Jockey Club "Peace and Awareness" Mindfulness Culture in Schools Initiative, Faculty of Social Sciences, The University of Hong Kong
Study officials:
References:
Clinical trial NCT03589391: New Mechatronic Device for Epidural Space Detection
Official title: A New Pressure Guided Mechatronic Tool for Epidural Space Detection: Feasibility Assessment in a Clinical Scenario
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Non Invasive Monitoring of Loss of Resistance During Epidural Injection
Keywords: Epidural injection
loss of resistance detection
mechatronic device
Lead sponsor: Campus Bio-Medico University
Sponsor class: OTHER
First posted: 2018-07-17
Enrollment: 34
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DEVICE_FEASIBILITY

Brief summary: This study sought to perform the feasibility assessment of a new, non-invasive device for Loss of Resistance (LOR) detection in clinical settings. The device in charge is a mechatronic device optimized in its configurations in order to detect Loss of Resistance while performing epidural injections.


Eligibility criteria: Inclusion Criteria:

* patients whose pathology requires specific treatment such as epidural infiltration

Exclusion Criteria:

* coagulation abnormalities or assumption of anticoagulant drugs

Primary outcomes:
measure: Loss of resistance detection
timeFrame: throughout the epidural infiltration procedure
Secondary outcomes:
Other outcomes:
Locations:
city: Rome
country: Italy
facility: Campus Bio Medico
state: RM
city: Rome
country: Italy
facility: University Hospital Campus BioMedico
Study officials:
affiliation: University Campus Bio-Medico of Rome
name: Massimiliano Carassiti, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Tesei M, Saccomandi P, Massaroni C, Quarta R, Carassiti M, Schena E, Setola R. A cost-effective, non-invasive system for pressure monitoring during epidural needle insertion: Design, development and bench tests. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:194-197. doi: 10.1109/EMBC.2016.7590673.
citation: Carassiti M, Biselli V, Cecchini S, Zanzonico R, Schena E, Silvestri S, Cataldo R. Force and pressure distribution using Macintosh and GlideScope laryngoscopes in normal airway: an in vivo study. Minerva Anestesiol. 2013 May;79(5):515-24. Epub 2013 Feb 18.
citation: Carassiti M, Mattei A, Pizzo CM, Vallone N, Saccomandi P, Schena E. Bronchial blockers under pressure: in vitro model and ex vivo model. Br J Anaesth. 2016 Sep;117 Suppl 1:i92-i96. doi: 10.1093/bja/aew120. Epub 2016 Jun 14.
citation: Carassiti M, Mattei A, Quarta R, Massaroni C, Saccomandi P, Tesei M, Setola R, Schena E. A New Pressure Guided Management Tool for Epidural Space Detection: Feasibility Assessment on a Simulator. Artif Organs. 2017 Dec;41(12):E320-E325. doi: 10.1111/aor.13007. Epub 2017 Oct 25.
citation: Carassiti M, Quarta R, Mattei A, Tesei M, Saccomandi P, Massaroni C, Setola R, Schena E. Ex vivo animal-model assessment of a non-invasive system for loss of resistance detection during epidural blockade. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul;2017:759-762. doi: 10.1109/EMBC.2017.8036935.
Clinical trial NCT02285491: Local Anesthetic Injection Into Both Angles of the Rectus Sheath Incision
Official title: Efficacy of Local Anesthetic Injection Into Both Angles of the Rectus Sheath Incision for Postoperative Cesarean Delivery Analgesia.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Postoperative Cesarean Delivery Pain
Lead sponsor: Ain Shams Maternity Hospital
Sponsor class: OTHER
First posted: 2014-11-07
Enrollment: 225
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Local anesthetic will be injected into both angles of the rectus sheath incision in an attempt to block sensory nerves in this area that cause the sensation of pain from lscs wound.


Eligibility criteria: Inclusion Criteria:

* patients booked for lscs
* primisection
* singleton pregnancy

Exclusion Criteria:

* emergency cesarean section
* bleeding tendency
* hypersensitivity to local anesthetic

Primary outcomes:
measure: Pain assessment during rest and ambulation by visual analogue scale
timeFrame: for 24 hours after lscs
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams Maternity Hospital
Study officials:
References:
Clinical trial NCT00172991: Adiponectin Gene and Coronary Artery Disease
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Coronary Artery Disease
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2005-09-15
Sex: ALL
Minimum age (years): 20
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_CONTROL
Time perspective: OTHER

Brief summary: Genetic studies of coronary artery disease, restenosis after angioplasty or stenting, focusing on renin-angiotensin system genes and adiponectin gene, and their interactions.


Eligibility criteria: Inclusion Criteria:

* Patients receiving angiography

Exclusion Criteria:

* Patients receiving angioplasty and reluctant for the study

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital
name: Chia-Ti Tsai
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04820491: Efficient Anterior Shoulder Ultrasound Reduction Multicenter Prospective Randomized Trial
Official title: EASiUR Trial: Efficient Anterior Shoulder Ultrasound Reduction Multicenter Prospective Randomized Trial
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Shoulder Dislocation
Lead sponsor: Virginia Commonwealth University
Sponsor class: OTHER
First posted: 2021-03-29
Enrollment: 9
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of the study is to determine if using ultrasound to diagnosis and confirm reductions of shoulder dislocations impacts the length of an emergency department visit for this condition.

Detailed description: The purpose of the study is to determine if the length of the emergency department visit can be decreased and if patient exposure to x-rays can be reduced by utilizing an ultrasound to diagnose and confirm reduction in shoulder dislocations.

This study also seeks to determine if patients prefer ultrasound to x-ray when used to treat their shoulder dislocation.

Participants will be randomly assigned to one of two groups: either x-rays or ultrasound for the diagnosis and reduction confirmation of your shoulder dislocation.

Participant's shoulder dislocation will be treated per standard of care.

Participants will be asked to complete a short survey at the end of their visit.

Eligibility criteria: Inclusion Criteria:

1. Patients who are 18 years of age or older; and
2. Present to the VCU Emergency Department; and
3. Have clinical signs of uncomplicated shoulder dislocation; and
4. Agree to participation in the study; and
5. Provides a written consent to be included in the study.

Exclusion Criteria:

1. Patients who have a level 1 or 2 trauma activation, and/or;
2. Patients who are pregnant, incarcerated, or unable to consent, and/or;
3. Patients who have a past medical history of shoulder replacement in dislocated shoulder; and/or
4. Provider Discretion

Primary outcomes:
measure: Length of Stay in the Emergency Department (ED)
timeFrame: up to 8 hours or time to admission
Secondary outcomes:
measure: Patient Satisfaction
timeFrame: at discharge or admission - up to 8 hours
measure: Time to Diagnosis
timeFrame: up to 8 hours or time to admission
measure: Confirmation of Reduction
timeFrame: up to 8 hours or time to admission
measure: Cost of Treatment
timeFrame: up to 8 hours or time to admission
measure: Total Number of Xrays
timeFrame: up to 8 hours or time to admission
Other outcomes:
Locations:
city: Richmond
country: United States
facility: Virginia Commonwealth University
state: Virginia
Study officials:
affiliation: Virginia Commonwealth University
name: Jordan Tozer, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06646991: Comparison of Several Oxygenation Targets With Different Oxygen Interfaces - Impact on Oxygen Flow Rates
Official title: Comparison of Several Oxygenation Targets With Different Oxygen Interfaces - Impact on Oxygen Flow Rates
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Oxygen Toxicity
COPD Bronchitis
Respiratory Failure
Lead sponsor: Laval University
Sponsor class: OTHER
First posted: 2024-10-17
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: SUPPORTIVE_CARE

Brief summary: Oxygen therapy is at the heart of the healthcare system. Oxygen flow rates depend on a number of confounding factors confounding factors (target used, skin pigmentation, pulse oximeter used, etc.) The investigators have recently have recently demonstrated that the combination of these factors (different peripheral oxygen saturation (SpO2) targets and different oximeters) can have a significant impact on oxygen flows rates. The effect on oxygen flow was not simply additive .

The aim of this study is to evaluate the impact of the interface used on oxygen flow rates in different patient populations (main objective). The investigatoers also evaluate the impact of the interface on carbon dioxide (PaCO2), in particular with closed oxygen masks, with which rebreathing is theoretically possible (secondary objective).

secondary objective).


Eligibility criteria: Inclusion Criteria:

* Adult (\> or = 18 years old)
* Ongoing on conventional oxygen therapy with peripheral oxygen saturation (SpO2) between 88 and 100% with the usual oximeter
* SpO2 \< 92% ambient air with the usual oximeter

Exclusion Criteria:

* No SpO2 signal with with the usual oximeter
* False nails or nail polish
* Severe anemia documented on last blood count during current hospitalization (haemoglobin (Hb) \< 80g/L)
* Oxygen flow \> 6 L/min

Primary outcomes:
measure: Oxygen flow
timeFrame: Mean Oxygen flow in the five last minute of each study period (between minute 10 and 15)
Secondary outcomes:
measure: Partial oxygen weaning
timeFrame: Mean oxygen flow in the five last minute of each study period (between minute 10 and 15)
measure: Complete oxygen weaning
timeFrame: Mean oxygen flow in the five last minute of each study period (between minute 10 and 15)
Other outcomes:
measure: Gaps between the different oximeters
timeFrame: through period completion, minute 15
measure: Gaps between PaCO2
timeFrame: through period completion, minute 15
Locations:
city: Quebec
country: Canada
facility: Institut Universitaire de Cardiologie et de Pneumologie de Québec
Study officials:
References:
Clinical trial NCT02229591: Expiratory Flow Limitation and Postoperative Complications
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Postoperative Respiratory Complications
Lead sponsor: Università degli Studi di Ferrara
Sponsor class: OTHER
First posted: 2014-09-01
Enrollment: 330
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing abdominal, thyroid or vascular surgery in Sant'Anna Hospital

Brief summary: Expiratory flow limitation (EFL) occurs when flow ceases to increase with increasing expiratory effort. In any circumstances EFL predisposes to pulmonary dynamic hyperinflation and its unfavorable effects such as increased elastic work of breathing, inspiratory muscles dysfunction, and progressive neuroventilatory dissociation, leading to reduced exercise tolerance, marked breathlessness during effort, and severe chronic dyspnea. Our hypothesis is that EFL should affect post operative outcomes like incidence of pulmonary complication and length of stay in hospital


Eligibility criteria: Inclusion Criteria:

* General anesthesia
* Duration of the surgery \>2 hours

Exclusion Criteria:

* \<18 years
* Consensus not given

Primary outcomes:
measure: Pulmonary complication
timeFrame: 28 days
Secondary outcomes:
Other outcomes:
Locations:
city: Ferrara
country: Italy
facility: Azienda Ospedaliero Universitaria Sant'Anna
Study officials:
References:
Clinical trial NCT05029791: Variations of Immune Infiltrate and Cell Plasticity Markers in Treated Metastatic Melanoma Patients
Official title: Study of Variations of Immune Infiltrate and Cell Plasticity Markers in Patients With Metastatic Melanoma Under Treatment
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Melanoma
Keywords: Melanoma
Immune Infiltrate
Cell plasticity markers
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2021-09-01
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: COLEMAN is an opened prospective monocentric non-randomized study, initiated by the Hospices Civils de Lyon. Population targeted are patients from 18 years old with stage III or IV metastatic melanoma eligible for a metastatic melanoma treatment administered as part of usual care.

The objective is to study the variations of immune infiltrate and cell plasticity before and under immunotherapy or targeted therapy. Two biopsies are done before and one month after the treatment initiation and one blood sample is done after the treatment initiation.

100 patients will be included and followed during 5 years.


Eligibility criteria: Inclusion Criteria:

* Patient age ≥ 18
* Female patients must agree to the use of 2 methods of contraception. For man one method of contraception is needed if if his partner is in childbearing age throughout the study and for at least 5 months after last study treatment administration.
* Patients with metastatic stage III or IV melanoma relapse
* Eligible for a melanoma metastatic treatment indicated and administered as part of usual care
* Patients must be willing and able to undergo cutaneous tumor biopsies (except on the face and folds or lymph node) according to the study protocol
* Patient insured or beneficiary of a health insurance plan
* Patient able to provide informed consent and sign approved consent forms to participate in the study
* Patient accepting the conservation of biological samples and their use for clinical research including genetic research

Exclusion Criteria:

* Hematologic tumours under treatment
* Patients with a documented history of autoimmune pathology
* Ocular melanoma
* Persons placed under the safeguard of justice
* Use of immunosuppressants including corticosteroids 4 weeks before the inclusion

Primary outcomes:
measure: CD8+ T cells
timeFrame: Month 1 before chemotherapy
measure: CD8+ T cells
timeFrame: Month 1 after chemotherapy
measure: expression of ZEB1 protein
timeFrame: Month 1 before chemotherapy
measure: expression of ZEB1 protein
timeFrame: Month 1 after chemotherapy
Secondary outcomes:
measure: Clinical response
timeFrame: Week 13
measure: Progression free survival
timeFrame: Week 13
measure: Progression free survival
timeFrame: Every year until 5 years
measure: overall survival
timeFrame: Week 13
measure: overall survival
timeFrame: Every year until 5 years
Other outcomes:
Locations:
city: Lyon
country: France
facility: Service de dermatologie (Bâtiment 1A)
Study officials:
References:
Clinical trial NCT03660891: OS NMB Depth Measured by Central and Peripheral Monitor.
Official title: Observational Study Measuring Neuromuscular Block Depth by a TOF or PTC Monitor on the Thumb and on the Upper Arm of the Same Side.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Neuromuscular Blockade
Lead sponsor: AZ Sint-Jan AV
Sponsor class: OTHER
First posted: 2018-09-07
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: all patients undergo a laparoscopic surgery and require a deep NMB.

Brief summary: Comparing during anesthesia in the same patient 2 neuromuscular monitors on the same arm.

Detailed description: NMT (neuromuscular transmission) depth can be measured at the same arm with two different methods during clinical practice.

the first (TOF Watch) measures the musculus adductor pollicis acceleration while the second method (TOF Cuff Monitor) uses a blood pressure cuff to measure the pressure changes induced by the upper arm muscles.

During general anesthesia when NMB (neuromuscular block) is required both methods are used. Every 5 minutes, if clinical required, the NMB is monitored by TOF-PTC. If the measurement of TOF is zero the monitor continues by measuring PTC ( the system will measure TOF followed by PTC if TOF is zero) TOF-PTC is recorded and later compared for identity or systematic difference in one or the other direction.

The measured answer can be TOF 4 (4 answers) with a ratio between answer 1 and 4 expressed and a percentage, TOF 3 (3 answers), TOF 2, TOF 1, TOF 0 + PTC 20, TOF 0 + PTC 19, up to TOF 0 + PTC 0

Eligibility criteria: Inclusion Criteria: all patients scheduled for an elective surgery requiring neuromuscular block during anesthesia

* laparoscopic surgery of upper abdomen including all types of bariatric surgery.

Exclusion Criteria: not possible to measure NMT (neuromuscular transmission) by cuff or thumb monitor

* upper arm obesity excluding the use of an upper arm blood pressure cuff
* allergy to NMB (neuromuscular blockers)
* contra indication for a deep NMB

Primary outcomes:
measure: TOF-PTC value
timeFrame: From induction of anesthesia (intubation with ETT) till end of anesthesia (extubation of ETT) most frequent between 1 and 2 hours, max 6 hours in duration
Secondary outcomes:
Other outcomes:
Locations:
city: Brugge
country: Belgium
facility: Azsintjan
Study officials:
affiliation: AZSint Jan AV
name: Jan Paul Mulier
role: PRINCIPAL_INVESTIGATOR
References: