Clinical trial NCT01836380: Regular Swimming, Vascular Function, and Arthritis
Official title: Effects of Swimming Exercise and Cycling Exercise Interventions on Vascular Function, Inflammation and Pain in Middle-aged and Older Adults With Osteoarthritis.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Osteoarthritis
Lead sponsor: University of Texas at Austin
Sponsor class: OTHER
First posted: 2013-04-19
Enrollment: 48
Sex: ALL
Minimum age (years): 40
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Hypothesis #1: The investigators hypothesize that both swimming training and cycling training will demonstrate significant improvements in endothelium-mediated vasodilation and central artery compliance in this population and that there will be no difference in the magnitude of increases between the water-based and land-based exercise interventions.

Hypothesis #2: The investigators hypothesize that the improvements in endothelium-dependent vasodilation and arterial compliance in response to exercise training interventions will be related to the corresponding reductions in inflammatory biomarkers.

Hypothesis #3: The investigators hypothesize that both swimming exercise and cycling exercise will improve functional capacities and disease progression in middle-aged and older adults with osteoarthritis.

Detailed description: Middle-aged and older men and women (40-90 years old) of all races and ethnic backgrounds will serve as subjects after obtaining their written, informed consent. All the subjects will have a radiological diagnosis of osteoarthritis according to American College of Rheumatology criteria.

Eligibility criteria: Inclusion Criteria:

* All the subjects will have a radiological diagnosis of osteoarthritis according to American College of Rheumatology criteria
* Subjects will be sedentary (i.e., no regular physical activity for at least the prior 1 year)

Exclusion Criteria:

* Subjects with significant intima thickening,
* plaque formation, and/or characteristics of atherosclerosis.
* unstable cardiac or pulmonary diseases.
* joint replacement surgery in the previous year.
* intraarticular injection nor systemic steroids within previous 3 months.
* severe disabling co-morbidity that disallows receiving exercise therapy.
* excess alcohol use (\>21 drinks/week).
* unwillingness to perform exercise.
* fear of water.
* mental incapability

Primary outcomes:
measure: Central Arterial Compliance
timeFrame: three months
measure: Inflammatory Markers
timeFrame: three months
measure: Flow-Mediated Dilatation
timeFrame: three months
Secondary outcomes:
measure: Mobility
timeFrame: three month
measure: Muscular Strength
timeFrame: three months
measure: Body Mass and Composition
timeFrame: three months
measure: Self-Reported Physical Function and Pain
timeFrame: three months
measure: Health-Related Quality of Life
timeFrame: three months
Other outcomes:
Locations:
city: Austin
country: United States
facility: The University of Texas at Austin
state: Texas
Study officials:
References:
citation: Alkatan M, Baker JR, Machin DR, Park W, Akkari AS, Pasha EP, Tanaka H. Improved Function and Reduced Pain after Swimming and Cycling Training in Patients with Osteoarthritis. J Rheumatol. 2016 Mar;43(3):666-72. doi: 10.3899/jrheum.151110. Epub 2016 Jan 15.
citation: Alkatan M, Machin DR, Baker JR, Akkari AS, Park W, Tanaka H. Effects of Swimming and Cycling Exercise Intervention on Vascular Function in Patients With Osteoarthritis. Am J Cardiol. 2016 Jan 1;117(1):141-5. doi: 10.1016/j.amjcard.2015.10.017. Epub 2015 Oct 22.