Clinical trial NCT01107691: Comparison of 1 vs 3 Sets of Resistance Training on Muscular Hypertrophy
Official title: Resistance Training Energy Balance & Weight Management
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Keywords: resistance and weight loss training
Lead sponsor: University of Kansas
Sponsor class: OTHER
Collaborators: name: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
First posted: 2010-04-21
Enrollment: 169
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study is designed to investigate the effects of two levels of resistance weight training on body composition, energy expenditure, and energy intake in men and women. The weight training will take about one hour to complete. Participants will perform the training 3 days per week for 9 months in a private exercise room equipped with state of the art equipment and a personal trainer to help guide you through the exercises.

The project lasts 21 months total with one follow-up visit 1-year from your last training date. You will be required to stay in the Lawrence area and train 3 day/week over the summer \& holidays.

Detailed description: We propose to conduct a randomized controlled efficacy trial (RT-1 set vs. RT-3 sets vs. non exercise control) to evaluate the potential for a longer intervention (9 months RT with body composition assessments 1 yr post RT completion) with a higher volume of RT (3 sets) to enhance the effects on body composition and energy expenditure observed in the pilot, and to determine the impact of the 2 levels of RT on free-living energy balance (expenditure by doubly labeled water and intake by digital photography and 24-hr recalls). This investigation will be conducted in a sample of healthy, normal and overweight, sedentary, young adult men and women; a group at high risk for development of overweight and obesity. The specific aims of this project are to determine the impact of the volume (1 vs. 3 sets) of a progressive RT protocol for inducing muscular hypertrophy, as recommended by the American College of Sports Medicine, on body weight and body composition (fat mass, fat-free mass (FFM), % body fat) and energy balance. Our results will provide information relative to the minimum volume of RT that may be associated with body weight/fat gain which may inform the development of guidelines for RT to prevent weight gain or to alter body composition. If RT has a favorable impact on energy balance and body composition, it may provide an attractive alternative to aerobic exercise for weight management for busy young adults, as RT requires minimal time, and no need to change clothes or shower (i.e. minimal or no sweating).

Eligibility criteria: Inclusion Criteria:

* BMI 22-\<30
* 18- 30 years old
* sedentary
* no medications
* weight stable for at least 3 months

Exclusion Criteria:

* Tobacco/Drug user
* metabolism altering medication
* gain/lost 10lbs in the last 3 months
* current exerciser

Primary outcomes:
measure: Body Composition
timeFrame: 21 Months
Secondary outcomes:
measure: Resting Metabolic Rate
timeFrame: 9 months
measure: Muscular Strength
timeFrame: 9 months
measure: Daily Energy Expenditure
timeFrame: 9 months
Other outcomes:
Locations:
city: Lawrence
country: United States
facility: Energy Balance Lab, The University of Kansas
state: Kansas
Study officials:
affiliation: University of Kansas
name: Richard A Washburn, PhD
role: PRINCIPAL_INVESTIGATOR
References: