louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03204526: Low Frequency Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease
Official title: Safety and Feasibility of Using Low Frequency Deep Brain Stimulation of the Subthalamic Nucleus to Improve Cognitive Performance in Patients With Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Parkinson Disease
Cognitive Impairment
Lead sponsor: University of California, Davis
Sponsor class: OTHER
First posted: 2017-07-02
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Prospective trial of low frequency deep brain stimulation of the ventral subthalamic nucleus to improve cognitive performance in patients with advanced Parkinson's disease. All study participants have undergone DBS implantation surgery as part of their routine care for motor manifestations of Parkinson's disease. In this study, a temporary low frequency period of stimulation will be applied to determine its effects on cognition.

Detailed description: In this randomized cross-over pilot study, our primary aim was to determine the effect of theta (5 Hz), and gamma (130 Hz) frequency stimulation in the ventral STN on cognitive control in patients with PD. This study provides a first look at frequency dependent modulation of cognitive function and provides important insights into the utility of DBS for non-motor symptoms of PD and other neuropsychiatric disorders.

Eligibility criteria: Inclusion Criteria:

* Parkinson's disease, undergoing deep brain stimulation implantation as part of their routine management of motor symptoms.

Exclusion Criteria:

Primary outcomes:
measure: Mean Reaction Time for Computerized Color Naming Stroop Task
timeFrame: 2 days
measure: Mean Accuracy Rates Using Computerized Color Naming Stroop Task
timeFrame: 2 days
Secondary outcomes:
measure: Number of Participants With Worsening Depression Using Beck's Depression Index
timeFrame: 2 days
measure: Number of Participants Showing Motor Worsening Using the Unified Parkinson's Disease Rating Scale (UPDRS-III)
timeFrame: 2 days
Other outcomes:
Locations:
city: Sacramento
country: United States
facility: University of California, Davis
state: California
Study officials:
References:
Clinical trial NCT01021826: Perioperative Hyperglycaemia in Primary Total Hip and Knee Replacement
Official title: Determinants of Perioperative Hyperglycaemia in Primary Hip and Knee Replacement
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Knee Replacement
Hip Replacement
Hyperglycemia
Keywords: knee replacement
hip replacement
hyperglycemia
diabetes
osteoarthritis
Lead sponsor: Coxa, Hospital for Joint Replacement
Sponsor class: OTHER
Collaborators: name: Tampere University
First posted: 2009-11-30
Enrollment: 193
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: tertiary care clinic

Brief summary: The purpose of this study is to analyze how common stress hyperglycaemia (abnormally high blood glucose) is in primary hip and knee replacement surgeries and which factors predispose to hyperglycaemia.

Detailed description: Postoperative infections remain one of the most frequent reasons of failure of hip and knee prostheses. Diabetes increases the risk of infections. In other fields of surgery, hyperglycemia induced by surgical stress (stress/perioperative hyperglycemia) has been associated with higher rates of postoperative infections and complications. Such studies have not yet been performed in the field of joint replacement surgery. Unlike several other risk factors of infected joint replacements, hyperglycemia is potentially modifiable and therefore its prevalence, predisposing factors and association with postoperative infections are of interest.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of osteoarthritis
* Scheduled for primary hip or knee replacement

Exclusion Criteria:

* Arthritis other than osteoarthritis
* Medication affecting glucose metabolism (excl. antidiabetic agents)
* Not undergoing hip or knee replacement

Primary outcomes:
measure: Occurrence (and severity) of hyperglycemia following primary hip or knee replacement
timeFrame: 3 days (average)
Secondary outcomes:
measure: Incidence of surgical-site infections
timeFrame: 1 year
measure: Prevalence of glucose metabolism disorders and metabolic syndrome
timeFrame: Baseline
Other outcomes:
Locations:
city: Tampere
country: Finland
facility: Coxa, Hospital for Joint Replacement
Study officials:
affiliation: Coxa, Hospital for Joint Replacement
name: Teemu Moilanen, MD, PhD
role: STUDY_DIRECTOR
affiliation: Coxa, Hospital for Joint Replacement
name: Esa Jämsen, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Tampere University Hospital
name: Pasi Nevalainen, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Jamsen E, Nevalainen PI, Eskelinen A, Kalliovalkama J, Moilanen T. Risk factors for perioperative hyperglycemia in primary hip and knee replacements. Acta Orthop. 2015 Apr;86(2):175-82. doi: 10.3109/17453674.2014.987064. Epub 2014 Nov 18.
Clinical trial NCT06892457: PHArmacotherapy Assessed Using Neuroprobing With TransOsseal Magnetic Stimulation
Official title: PHArmacotherapy Assessed Using Neuroprobing With TransOsseal Magnetic Stimulation
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Epilepsy
Keywords: Brain Excitability
Anti-Seizure Medication
Transcranial Magnetic Stimulation
Lead sponsor: Insel Gruppe AG, University Hospital Bern
Sponsor class: OTHER
First posted: 2025-03-24
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients (≥ 18j) with epilepsy receiving a prescription for an anti-seizure medication for clinical reasons.

Brief summary: The goal of this observational study is to investigate how prescribed anti-seizure medications (ASMs) affect cortical excitability in adults with epilepsy. The main questions it aims to answer are:

1. Does the magnitude of transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) measured with electroencephalography (EEG) change between OFF and ON medication states?
2. Do these changes in TEP amplitude persist over time? Researchers will compare each participant's measurements in the OFF state with those in the ON state to see if TEPs change following ASM (re)start.

Participants will undergo one TMS-EEG session scheduled around their prescribed ASM (re)start and one 1-6 months later.


Eligibility criteria: Inclusion Criteria:

* Adult patients (≥ 18j) with epilepsy receiving a prescription for an anti-seizure medication for clinical reasons
* Written informed consent

Exclusion Criteria:

* Presence of any electrical implants (e.g. neurostimulator or drug delivery system) or any metallic implants anywhere in the head (excluding teeth)
* Increased intracranial pressure
* Uncontrolled psychiatric disorder
* Use of any kind of drug or alcohol, nicotine allowed
* For female participants: If pregnancy cannot be ruled out with sufficient certainty, a pregnancy test (urine) will be carried out before using TMS
* Inability to give consent

Primary outcomes:
measure: Change in TEP magnitude
timeFrame: 1 day
Secondary outcomes:
measure: Persistence of TEP changes over time.
timeFrame: 1-6 months
Other outcomes:
Locations:
city: Bern
country: Switzerland
facility: University Hospital Bern
Study officials:
affiliation: Bern University Hospital
name: Cecilia Friedrichs-Maeder, MD, MSc.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03101657: Evaluation of Total Disability (I.T.T.) in Victims of Psychotraumatism.
Official title: Evaluation of the Total Incapacity of Work (I.T.T.) in the Victims of Psychotraumatism Taken Care of in the Medico-judicial Unit of the CHU of Montpellier by Forensic Doctors and Psychologists
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Psychotraumatism
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2017-04-05
Enrollment: 250
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients suffering from psychotraumatism.

Brief summary: The increase in psychological violence in our society, but also and above all the search for the best possible reparation for this violence, leads increasingly to questioning the evaluation of psychotraumatisms. In practice, there is no consensus as to the method of assessing psychological repercussions and determining ITI. This topic concerns any physician

Detailed description: The increase in psychological violence in our society (psychological repercussions of physical violence, situations of harassment, psychotraumatism linked to the series of attacks suffered in France), but also and above all, the search for the best possible reparation for this violence The victims and the society), leads increasingly to question the evaluation of psychotraumatisms. In practice, there is no consensus as to the method of assessing psychological repercussions and determining ITI. This topic concerns any physician involved in the care of victims, whether he is a doctor in primary care or in specialized care.

Eligibility criteria: Inclusion criteria:

* Patients over 18 years of age taken in charge at the Médico-Judiciaire Unit of the CHU Montpellier following a physical and / or psychological traumatism. - - Starting up between 01.01.2016 and 31.12.2016.
* Patients who have undergone a double assessment (medical and psychological).

Exclusion criteria:

* Patients under the age of 18 years.
* Consultation within the framework of a takeover started before 01.01.2016.
* Absence of double medical and psychological evaluation.

Primary outcomes:
measure: Medico-psychological interviews
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University Hospital, Montpellier
name: thomas PERROT, Interne
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06164366: Patient Satisfaction and Adaptation of Dentures Printed at 0 Versus 45 Degrees
Official title: Patient Satisfaction and Adaptation of Maxillary Resin Dentures Printed at 0 Versus 45 Degrees Build Angle: A Randomized Pilot Cross-over Clinical Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Edentulous Jaw
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-12-11
Enrollment: 10
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: This pilot study aims to compare the difference, if present in patient satisfaction, denture base adaptation and retention in 3d printed maxillary complete dentures fabricated at a build angle of 0 degrees versus 45 degrees.

Detailed description: This pilot study aims to compare the difference, if present in patient satisfaction, denture base adaptation and retention in 3d printed maxillary complete dentures fabricated at a build angle of zero degrees versus forty five degrees. Since there is no sufficient evidence surrounding the topic at hand, a randomized clinical trial must be conducted in an attempt to gap the clinical knowledge regarding printing orientation and its effect on denture base adaptation and patient satisfaction. The main question and the one that needs further investigations as stated by Goodacre would these differences in these build up angles have a true clinical effect on denture adaptation and denture retention

Eligibility criteria: Inclusion Criteria:

1. Patients above the age of 40
2. Patients with opposing full natural dentition or completely or partially edentulous arches
3. Opposing arch should be either having a set of full natural dentition or is restored by fixed partial dentures or implants
4. Cooperative patients that are willing to attend all follow-up periods.
5. Patients with healthy attached mucosa of appropriate thickness free from any inflammation.

6- Patients free from any systemic disease that might affect the health of the bone or of the mucosa eg diabetes

Exclusion Criteria:

1. Patients with any temporomandibular joint disorder or parafunctional habits
2. Patients with flabby or flat ridges
3. Patients with extreme anatomical limitations such as a large torus that requires surgical excision.
4. Patients with a history of allergy to dentures made of resins.
5. Patients with pathological changes of residual ridges as recurrent or persistent ulcers, osteomyelitis and infections.
6. Patients with medical or psychological conditions as physical disability or mental retardation that hinder cooperation in the follow up visits and answering the questionnaires.

Primary outcomes:
measure: patient satisfaction
timeFrame: 6 months
measure: denture adaptation
timeFrame: 4 weeks
Secondary outcomes:
measure: Denture retention
timeFrame: 6 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03468166: Data Collection for Motor Function and Gait Pattern Analysis of Patients With Chronic Stroke
Official title: Data Collection for Motor Function and Gait Pattern Analysis of Patients With Chronic Stroke
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Stroke
Keywords: Motor function
Gait pattern
Lead sponsor: Samsung Medical Center
Sponsor class: OTHER
First posted: 2018-03-16
Enrollment: 120
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Subjects with chronic stroke who can walk outdoors

Brief summary: In chronic stroke patients, the data for motor function and gait pattern analysis was obtained.


Eligibility criteria: Inclusion Criteria:

* Stroke patients with hemiplegia over 19 years old
* Ischemic or hemorrhagic stroke patients over 6 months of onset
* Functional Ambulation Category Scale with 3 or more scales and a person who can walk independently regardless of using of walking aids
* A person who understands and voluntarily participates in this study and signs a research agreement

Exclusion Criteria:

* Patients of artificial heartbeat
* Patients with claustrophobia
* Patients with intracranial metal implants
* Patients who are contraindicated for other common MRI scans
* Patients difficult to walk due to problems such as visual field defect, fracture, severe muscle paralysis, cognitive impairment
* Those who have a score of FMA score of 80 or more and have very slight motor impairment

Primary outcomes:
measure: Gait analysis
timeFrame: 1 hour
Secondary outcomes:
measure: Fugl-Meyer assessment for lower extremity (FMA)
timeFrame: 20 minutes
measure: The Timed Up and Go test (TUG)
timeFrame: 10 minutes
measure: 10 meter walk test (10MWT)
timeFrame: 5 minutes
measure: Manual Muscle Test (MMT)
timeFrame: 15 minutes
measure: Range of Motion (ROM)
timeFrame: 15 minutes
measure: Functional Ambulation Classification (FAC)
timeFrame: 10 minutes
measure: Modified Bathel index (MBI)
timeFrame: 10 minutes
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
Study officials:
References:
Clinical trial NCT06456866: Assessing the Accuracy of ChatGPT-4 in Interpreting Arterial Blood Gas Results
Official title: Assessing the Accuracy of ChatGPT-4 in Interpreting Arterial Blood Gas Results
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Blood Gases
Keywords: artificial intelligence
Lead sponsor: Kanuni Sultan Suleyman Training and Research Hospital
Sponsor class: OTHER
First posted: 2024-06-13
Enrollment: 398
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: A minimum of 398 arterial blood gas samples from patients in the intensive care unit will be included in the study

Brief summary: Assessment of Acidosis and Alkalosis, Evaluation of Hypoxemia and Hyperoxemia, Evaluation of Hemoglobin Parameters, Assessment of Electrolytes, Evaluation of Metabolic Parameters (Glucose, Lactate, Bilirubin)

Detailed description: Model Training:

The collected data will be used to train the artificial intelligence model. Utilizing the deep learning infrastructure provided by ChatGPT Plus, our model will be optimized to produce highly accurate results in interpreting blood gases.

During the training process, our model will be taught to interpret various blood gas samples, including assessments of acidosis-alkalosis, hypoxemia-hyperoxemia, hemoglobin, electrolytes, and metabolic parameters.

Model Testing and Validation:

The trained model will be tested on previously unseen test datasets to evaluate its performance. This step is crucial for understanding how the model will perform in real-world scenarios.

The accuracy of the model will be assessed by comparing its interpretations with feedback provided by expert anesthesiologists.

Furthermore, to comprehensively evaluate ChatGPT's effectiveness in this domain, the daily arterial blood gas results obtained in the intensive care unit will be submitted to ChatGPT for interpretation. The same questions will be posed, and the responses will be evaluated by an anesthesiology and reanimation specialist. These questions will be asked to the model:

Assessment of Acidosis and Alkalosis, Evaluation of Hypoxemia and Hyperoxemia, Evaluation of Hemoglobin Parameters, Assessment of Electrolytes, Evaluation of Metabolic Parameters (Glucose, Lactate, Bilirubin)

Eligibility criteria: Inclusion Criteria:

* Patients aged 18 and above will be included in the study.
* The study will evaluate arterial blood gas results.

Exclusion Criteria:

* Venous blood gas results,
* Blood gas results with calibration errors,
* Blood gas results with incomplete data

Primary outcomes:
measure: blood gases sample interpretation
timeFrame: 10 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital
Study officials:
References:
Clinical trial NCT00005666: Utility of Anatometabolic Imaging for Radiation Treatment Planning for Lung Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Carcinoma, Non-Small-Cell Lung
Keywords: Diagnostic imaging
Lead sponsor: National Center for Research Resources (NCRR)
Sponsor class: NIH
First posted: 2000-05-22
Sex: ALL
Minimum age (years): 0
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: This is a research study for patients with inoperable lung cancer called non-small cell lung cancer (NSCLC). Currently, the information from a radiological test, computed tomography (CT) scan of the chest, is used to design the best arrangement of radiation beams which will kill tumor cells and still spare the normal parts of lungs and other normal organs in the chest. The purpose of this study is to explore whether adding information from another radiological test, called positron emission tomography (PET), will improve the accuracy of the radiation beam arrangement designed to treat lung cancer. A PET scan is a way to picture the biochemistry of tissues and organs: of how tissues in the body take up glucose, a normal nutrient of the body. The researchers will attempt to create radiation treatment plans from PET images alone and compare differences between hypothetical plans and standard-of-care CT-based radiation treatment plans. Because there is honest uncertainty about the contribution of PET to radiation treatment planning, it is possible that there will be no difference between a CT-based treatment plan and one resulting from PET information. It is also possible that the addition of PET may result in a radiation beam arrangement that may better control lung cancer. The addition of PET may also result in treating less normal tissues, which may lower the risk of radiation side effects. This study will provide the preliminary data necessary to design a larger clinical trial that may define the role of PET in radiation treatment planning.


Eligibility criteria: Inclusion Criteria:

* Histologically confirmed locally advanced NSCLC (squamous, large cell undifferentiated or adenocarcinoma).
* Disease limited to the thorax, adjacent mediastinum and neurovascular structures, and supraclavicular or scalene lymph node area, as defined by the AJCC Staging System. This includes patients with Stage IIIA and IIIB disease.
* Performance status of 0-2 by Southwest Oncology Group criteria.
* Medically inoperable patients (Stage I or II)
* Locoregional recurrent tumor following surgery will be eligible provided they meet other eligibility criteria.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: UH B2 C490 Box 0010 E. Medical Center Drive
state: Michigan
Study officials:
References:
Clinical trial NCT06752226: Effect of AO Training on Gross Motor Function in Children with Spastic Cerebral Palsy
Official title: Effect of Action Observation Training on Gross Motor Function in Children with Spastic Cerebral Palsy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diplegic Spastic Cerebral Palsy
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-12-30
Enrollment: 30
Sex: ALL
Minimum age (years): 4
Maximum age (years): 7
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: parallel study is a type of clinical study in which two or more groups of participations receive different interventions
Primary purpose: TREATMENT

Brief summary: The study was conducted to examine the impact of the action observation training (AOT) on gross motor function in children with spastic cerebral palsy.

Detailed description: Thirty children with spastic diplegic cerebral palsy aged from 4 to 7 years were randomly allocated into two groups of equal number; study group (A) and control group (B). Both groups received designed physical therapy program for 45 minutes, three times/ per week for two successive months. In addition, study group received action observation (AO) training for 30 minutes per session. All phases of gait cycle and functional ability of all children participating in both groups was assessed by kenovia software and gross motor function measure (GMFM) walking, running and jumping domain.

Eligibility criteria: Inclusion Criteria:

Age ranges from 4 - 7 years. Level Ι - Π according to Gross Motor Functional Classification System (GMFCS) (Appendix II).

Grade 1, +1 and 2 of the Modified Ashworth Scale (Appendix III). Able to follow verbal commands and instructions.

Exclusion Criteria:

* Significant visual or auditory impairments Structural or fixed soft tissue deformities of Lower extremities. Perception disorders. Botox injection in the lower extremity in the past 6 months.

Primary outcomes:
measure: Primary Outcome Measure
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: El giza
country: Egypt
facility: Faculty of physical therapy , Cairo university
Study officials:
References: