Clinical trial NCT01531101: First Experimental Study of Transference Work - In Teenagers (FEST-IT)
Official title: First Experimental Study of Transference Work - In Teenagers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Depression
Keywords: Transference work
Psychodynamic
Depression
Treatment
Adolescent
Lead sponsor: Sykehuset i Vestfold HF
Sponsor class: OTHER
Collaborators: name: University of Oslo
First posted: 2012-02-10
Enrollment: 70
Sex: ALL
Minimum age (years): 16
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The First Experimental Study on Transference work - In Teenagers (FEST-IT) will be a randomized clinical trial, which will be designed to explore effects of transference work in dynamic psychotherapy in adolescents with major depressive disorder (MDD). The design of the study is a so-called dismantling design, in which a single component is added and/or varied to an existent treatment method (psychodynamic psychotherapy). Thus, the efficiency of a specific technique (transference interventions) can be identified.

The primary hypothesis is that the transference group may have a more favorable course over time than will the comparison group.

The second hypothesis is that patients with a history of low Quality of Object Relations score and/or personality disorders-might benefit more from therapy with transference work than from therapy without.

The third hypothesis is that female adolescents may have better treatment effect of transference work than male adolescents.

Detailed description: The effect of transference interventions in depressed adolescents and the moderator moderating effect of quality of object relations, personality disorder and gender will be explored. Methods and study design: The First Experimental Study of Transference Work-In Teenagers (FEST-IT) will be a randomized clinical trial with a dismantling design. The study is aimed to explore the effects of transference work in psychodynamic psychotherapy for adolescents with depression. One hundred patients ages 16 to 18 years old will be randomized to one of two treatment groups, in both of which general psychodynamic techniques will be used. The quality of adolescents' relationships will be a central focus of the study.The patients will be treated over 28 weeks with either a moderate level of transference intervention or no transference intervention. Follow-up will be at 1 year after treatment termination.

Gender personality disorder (PD) and quality of object relations (QOR) will be the preselected moderators.

The object of this clinical trial is to explore the effect of transference interventions in psychodynamic psychotherapy in adolescents with a major depressive disorder. Using a randomized and dismantling design, we hope that the study will add more specific knowledge to the evidence base.

Eligibility criteria: Inclusion Criteria:

* Adolescents aged 16 - 18 years

Exclusion Criteria:

* Pervasive developmental disorder,
* psychosis, or substance abuse

Primary outcomes:
measure: Psychodynamic Functioning Scales (PFS)
timeFrame: 3 months
measure: Inventory of Interpersonal Problems-Circumplex Version (IIP-C)
timeFrame: Currentl
Secondary outcomes:
measure: Global Assessment of Functioning (GAF)
timeFrame: One week
measure: Symptom Checklist-90 (Global Severity Index; GSI)
timeFrame: Current
measure: Beck Depression Inventory (BDI)
timeFrame: Current
measure: Montgomery Åsberg Rating Scale (MADRS)
timeFrame: Current
Other outcomes:
measure: Adolescent Relationship Scale (ARS)
timeFrame: Current
Locations:
city: Tønsberg
country: Norway
facility: Research Unit, Division of
state: Vestfold
city: Oslo
country: Norway
facility: BUP vest, Diakonhjemmet sykehus
city: Oslo
country: Norway
facility: Nic Walls Institutt, Lovisenberg Diakonale Sykehus
city: Oslo
country: Norway
facility: Oslo University Hospital
city: Oslo
country: Norway
facility: Spcialist in psychiatry and clinical psychiatry
city: Oslo
country: Norway
facility: University of Oslo
Study officials:
affiliation: Vestfold Hospital Trust and University of Oslo
name: Randi Ulberg, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Brosholen P, Ulberg R, Dahl HJ, Thoren A. Therapists' Emotional Responses in Individual Therapy with Depressed Adolescents: An Evaluation of the Data Structure of the Feeling-Word Checklist-28. Int J Environ Res Public Health. 2022 Aug 2;19(15):9496. doi: 10.3390/ijerph19159496.
citation: Henriksen AK, Ulberg R, Tallberg BPU, Lovgren A, Johnsen Dahl HS. Conflicted Anger as a Central Dynamic in Depression in Adolescents-A Double Case Study. Int J Environ Res Public Health. 2021 Jun 15;18(12):6466. doi: 10.3390/ijerph18126466.
citation: Ulberg R, Hummelen B, Hersoug AG, Midgley N, Hoglend PA, Dahl HJ. The first experimental study of transference work-in teenagers (FEST-IT): a multicentre, observer- and patient-blind, randomised controlled component study. BMC Psychiatry. 2021 Feb 17;21(1):106. doi: 10.1186/s12888-021-03055-y.
citation: Lovgren A, Rossberg JI, Nilsen L, Engebretsen E, Ulberg R. How do adolescents with depression experience improvement in psychodynamic psychotherapy? A qualitative study. BMC Psychiatry. 2019 Mar 21;19(1):95. doi: 10.1186/s12888-019-2080-0.
citation: Ness E, Dahl HJ, Tallberg P, Amlo S, Hoglend P, Thoren A, Egeland J, Ulberg R. Assessment of dynamic change in psychotherapy with asdolescents. Child Adolesc Psychiatry Ment Health. 2018 Jul 30;12:39. doi: 10.1186/s13034-018-0246-z. eCollection 2018.
citation: Ulberg R, Hersoug AG, Hoglend P. Treatment of adolescents with depression: the effect of transference interventions in a randomized controlled study of dynamic psychotherapy. Trials. 2012 Sep 6;13:159. doi: 10.1186/1745-6215-13-159.