Clinical trial NCT01294930: Indicators of Operative and Postoperative Complications in Patients Operated for Hip Fracture
Official title: Indicators of Operative and Postoperative Complications in Patients Operated for Hip Fracture
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hip Fracture
Keywords: hip fracture
mortality
complications
Lead sponsor: University Hospital, Linkoeping
Sponsor class: OTHER
Collaborators: name: Vrinnevi Hospital
First posted: 2011-02-14
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with hip fracture operated at the hospital in Norrkoeping

Brief summary: Patients operated for hip fractures are older and have several conditions that have negative influences on the perioperative and postoperative prognosis.

Hip fractures can also be painful, which is stressful for the physiology of the patient. Many old patients have received to little fluid intake. They often have diuretic therapy, which even worsens dehydration/hypovolemia.

Some patients have to wait several days for surgery. Several studies have shown a high degree of complications and an increased mortality in this patient group.

Early preoperative optimization can improve the outcome. The available methods for optimization of the patient are complicated and time consuming.

The investigators wish with this study to try new approaches to find which patients still are dehydrated when they come to the operation ward.

The aim is to measure the color and density of the urine as well as to register the the variability in the plethysmographic curve before spinal anaesthesia.

These results will be compared to circulatory instability during and after surgery as well as to postoperative complications.

Detailed description: All patients with hip fractures planed fore surgery at the Hospital in Norrkoping will come into consideration to participate in study.

Many will however not be able to give consent. These will not be included in the study.

Directly preoperatively urine will be collected. Color and density will be measured/registered.

The pulseoximeter reading will be registered (Saturation, pulse, PI and PVI) before spinal anaesthesia and after spinal anaesthesia as well as during the surgery.

Two to three days postoperatively a follow up will be performed, to register complications (Circulatory instability, confusion, infection, affected kidney function/creatinine rise).

30 day postoperative mortality will also be controlled.

These results will be compared, to see if pulse oximeter readings or urine concentration can predict complications.

Eligibility criteria: Inclusion Criteria:

* patients with hip fracture
* operation for the hip fracture
* informed consent

Exclusion Criteria:

* patients not giving consent
* patients not being able to understand information

Primary outcomes:
measure: mortality
timeFrame: 30 days
Secondary outcomes:
measure: operative and postoperative complications
timeFrame: 3 days
Other outcomes:
Locations:
city: Norrkoeping
country: Sweden
facility: Anaesthesia dept, Vrinnevisjukhuset
Study officials:
affiliation: University Hospital, Linkoeping
name: Robert Hahn, MD PhD Prof
role: STUDY_DIRECTOR
References:
citation: Ylinenvaara SI, Elisson O, Berg K, Zdolsek JH, Krook H, Hahn RG. Preoperative urine-specific gravity and the incidence of complications after hip fracture surgery: A prospective, observational study. Eur J Anaesthesiol. 2014 Feb;31(2):85-90. doi: 10.1097/01.EJA.0000435057.72303.0e.