Clinical trial NCT03601104: Effects of Low Intensity, High Intensity Eccentric Resistance Training Associated With Blood Flow Restriction
Official title: Effects of Low Intensity, High Intensity Eccentric Resistance Training Associated With Blood Flow Restriction: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise
Keywords: Eccentric Training
Resistance Training
Lead sponsor: Paulista University
Sponsor class: OTHER
First posted: 2018-07-26
Enrollment: 61
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Introduction: studies on resistance training of low intensity associated with blood flow restriction in recent years, although there are still gaps that can be explored in relation to their physiological phenomena when associated with eccentric training. In this way, from there the exploration becomes relevant the investigation of eccentric training associated to an RFS. Objective: To analyze and compare the effects of a high intensity and low intensity intensive resistance training associated with an RFS (TREAI-RFS and TREBI-RFS) with a high intensity eccentric resistance training without RFS (TREAI) in knee extensors. Method: The study will consist of 45 male participants, allocated from a stratified randomization into three groups: TREAI (n = 15), TREAI-RFS (n = 15) and TREBI-RFS (n = 15). Participants underwent a training program with a minimum of 40% without RFS, 80% with RFS and 40% with CVS of CVIM, 3 times a week, and the outcomes of muscle strength, muscle structure, power test and Endothelial growth will be assessed one week before, the fourth week and one week after the end of the training program. In addition, clinical markers of perception and recovery effort are investigated before and after a session. The graph used is descriptive and descriptive, as it is used as a model of analysis of variance for the analysis of replications without a two-factor scheme, which provides detailed information on how the measures are repeated, neither. A whole statistical analysis can reach the level of significance of 5%.


Eligibility criteria: Inclusion Criteria:

* male sex;
* healthy;
* aged between 18 and 35 years

Exclusion Criteria:

* smokers;
* alcoholics;
* use drugs that influenced cardiac autonomic activity;
* cardiovascular, metabolic or endocrine diseases.

Primary outcomes:
measure: Change in muscle strength torque peaks at dinamometer isokinetic
timeFrame: baseline, fourth week and one week after sixth week
measure: Change in muscular structure with ultrasonography
timeFrame: baseline, fourth week and one week after sixth week.
measure: Change in Vascular Endothelial Growth Factor (VEGF)
timeFrame: baseline, fourth week and one week after sixth week.
measure: Change in muscle power test
timeFrame: baseline, fourth week and one week after sixth week.
Secondary outcomes:
measure: Pain threshold
timeFrame: Assessed at baseline, 4th week, and 6th week.
measure: Analog Visual Scale
timeFrame: Assessed at baseline, 4th week, and 6th week.
measure: Perceived Effort Scale (Borg)
timeFrame: Assessed at baseline, 4th week, and 6th week.
measure: Recovery Perception Scale
timeFrame: Assessed at baseline, 4th week, and 6th week.
Other outcomes:
Locations:
city: Presidente Prudente
country: Brazil
facility: Franciele Marques Vanderlei
state: SP
Study officials:
affiliation: Universidade Estadual Paulista - FCT / UNESP
name: Franciele Marques Vanderlei, PhD
role: PRINCIPAL_INVESTIGATOR
References: