louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01883440: Glucose Oxidase as Treatment Against Common Cold
Official title: A Placebo Controlled Study With a Nasal Spray Containing Glucose Oxidase, Aiming to Induce a Faster Recovery From an Episode of Common Cold
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Common Cold
Keywords: Duration
Lead sponsor: Umeå University
Sponsor class: OTHER
First posted: 2013-06-21
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Glucose oxidase is a hydrogen peroxide producing enzyme, which also is present in honey. Human rhinoviruses are sensitive to the action of hydrogen peroxide, which is documented in laboratory studies.

In the present study we aim to investigate if a nasal spray with glucose oxidase could treat a common cold, when the treatment is started even after the onset of the symptoms. The study is randomized and placebo controlled.

Detailed description: Persons that are convinced of that they have caught an episode of common cold can be included into the study within 24 hours after the onset of symptoms.

Before they start the treatment with the nasal spray they perform a viral sample from the nose and also fill in the WURSS-21 protocol. After this the persons spray with glucose oxidase+glucose/only saline+glucose 5 times the first day and thereafter 3 times daily for a total treatment of one week. Every day the included persons fill in the WURSS-21 protocol.

Eligibility criteria: Inclusion Criteria:

* Symptoms of a common cold within the last 24 hours

Exclusion Criteria:

* Use of a nasal steroid due to allergy

Primary outcomes:
measure: Sum of All Symptoms in Viruspositive Persons
timeFrame: One week
measure: Sum of All Symptoms of All Persons That Fullfilled the Study
timeFrame: 7 days
Secondary outcomes:
Other outcomes:
Locations:
city: Sunderbyn
country: Sweden
facility: Öronmottagningen
Study officials:
affiliation: Norrbottens Läns Landsting
name: Helena Toolanen, MD
role: STUDY_CHAIR
References:
Clinical trial NCT02728440: Effects of Gonadotropin Replacement Therapy on Metabolic Parameters in Patients With Hypogonadism
Official title: Lipid Profile and Oxidative Stress Parameters of Patients With Idiopathic Hypogonadotropic Hypogonadism and the Change of These Parameters With Gonadotropin Replacement Therapy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Idiopathic Hypogonadotropic Hypogonadism
Lead sponsor: Gulhane School of Medicine
Sponsor class: OTHER
First posted: 2016-04-05
Enrollment: 30
Sex: MALE
Minimum age (years): 22
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with Idiopathic Hypogonadotropic Hypogonadism and healthy control group

Brief summary: Effects of gonadotrophin replacement therapy Lipid Profile and Oxidative Stress Parameters of Patients with Idiopathic Hypogonadotropic Hypogonadism

Detailed description: 30 male patients diagnosed with IHH and a control group of 20 healthy cases with similar age and BMI were included in the study. The levels of advanced oxidation protein products (AOPP), thiol, malondialdehyde (MDA), nitric oxide (NO) and 8-hydroxydeoxyguanosine (8-OHdG) and the levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-K), low density lipoprotein (LDL-K), Apolipoprotein A1 (ApoA1) and Apolipoprotein B100 (ApoB100) were measured before and after gonadotrophin therapy.

Eligibility criteria: Inclusion Criteria:

Serum testosterone concentration \< 300ng/dL Absence of a pituitary or hypothalamic mass lesions, Presence of gonadotropin response to GnRH, -

Exclusion Criteria:

diabetes mellitus, arterial hypertension other hormone deficiencies

-

Primary outcomes:
measure: oxidative stress after hCG and HMG treatment
timeFrame: 2010-2012
measure: HDL levels after hCG treatment
timeFrame: 2010-2012
measure: total cholesterole levels after hCG treatment
timeFrame: 2010-2012
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04123340: Intraprocedural Assessment of Ablation Margins Using Computed Tomography Co-registration in Primary Liver Tumor Treatment With Percutaneous Ablation
Official title: Intraprocedural Assessment of Ablation Margins Using Computed Tomography Co-registration in Primary Liver Tumor Treatment With Percutaneous Ablation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: HCC
Lead sponsor: Leiden University Medical Center
Sponsor class: OTHER
Collaborators: name: Mirada Medical
First posted: 2019-10-10
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: prospective, single blind, single-arm, phase II stud
Primary purpose: TREATMENT

Brief summary: A pre- and postablation scan will be made intraprocedurally to investigate the feasibility of intraprocedural ablation verification assessment using coregistration software


Eligibility criteria: Inclusion Criteria:

* Age 18 yrs or above
* HCC very early (0) or early stage (A) according to the BCLC staging system
* Either de novo or recurrent HCC (prior locoregional therapy is allowed in the study)
* Candidate for percutaneous thermal ablation as discussed in a multidisciplinary tumor board. Ablation as 'bridge-to-transplant' is allowed in the study

Exclusion Criteria:

* Estimated GFR \<30 ml/min
* Morbid obesitas or any pulmonary condition that is a contraindication to prolonged apnea and high jet-ventilation
* Child Pugh C
* Portal vein tumor invasion
* Extrahepatic metastasis
* Uncorrectable coagulopathy
* Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule
* Inability or unwillingness to give informed consent

Primary outcomes:
measure: Feasibility of the use of co-registration software (>80%)
timeFrame: 1 year
Secondary outcomes:
measure: Inter and intra-observer variability
timeFrame: 1 year
measure: The time that is required for CT-CT co-registration
timeFrame: 1 year
measure: Quantitatively assessed ablation margin
timeFrame: 1 year
Other outcomes:
Locations:
city: Leiden
country: Netherlands
facility: Leiden University Medical Center
state: Zuid-Holland
Study officials:
References:
Clinical trial NCT00656240: To Investigate the Safety and Efficacy of DE-104 Ophthalmic Solution to Treat Open-Angle Glaucoma or Ocular Hypertension
Official title: A Randomized, Double-Masked, Parallel-Group Trial of DE-104 Ophthalmic Solution in Subjects With Open-Angle Glaucoma or Ocular Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Open-Angle Glaucoma
Ocular Hypertension
Lead sponsor: Santen Pharmaceutical Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2008-04-11
Sex: ALL
Minimum age (years): 20
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: To investigate the intraocular pressure (IOP)-lowering effect and safety of DE-104 ophthalmic solution in patients with Primary Open-Angle Glaucoma or Ocular Hypertension


Eligibility criteria: Inclusion Criteria:

* Diagnosed with primary open-angle glaucoma or ocular hypertension.
* Provided signed, written informed consent.
* If a subject is a female of childbearing potential, she must utilize reliable contraceptive throughout the study, and must have a negative urine pregnancy test prior to enrollment into this study.

Exclusion Criteria:

* Females who are pregnant, nursing or planning a pregnancy, or females of childbearing potential who are not using a reliable method of contraception.
* Presence of any abnormality or significant illness that could be expected to interfere with the study.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Osaka
country: Japan
facility: Osaka, Japan
Study officials:
References:
Clinical trial NCT06917040: Enhancing Protection Against Vector-borne Diseases in Forcibly Displaced Communities: Evaluating the Efficacy of Spatial Repellents for Cutaneous Leishmaniasis Control in North-East Syria
Official title: Enhancing Protection Against Vector-borne Diseases in Forcibly Displaced Communities: Evaluating the Efficacy of Spatial Repellents for Cutaneous Leishmaniasis Control in North-East Syria
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Leishmaniasis, Cutaneous
Vector Borne Diseases
Keywords: Conflict
Internally displaced people
temporary shelter
spatial repellants
Lead sponsor: The Mentor Initiative
Sponsor class: OTHER
Collaborators: name: University of Nevada, Las Vegas
name: Hacettepe University
First posted: 2025-04-08
Enrollment: 18404
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of this study is to determine the efficacy of Mosquito Shield (spatial repellent) in reducing cutaneous leishmaniasis case incidence among internally displaced persons and sandfly density in temporary shelters and camp settings in Ar-Raqqa governorate, North-East Syria.


Eligibility criteria: Inclusion Criteria:

Known history of cutaneous leishmaniasis in camp Sleeping under same shelter type (all UNHCR tents / plastic sheets) Camp easily accessible by road Camps a minimum of 5km apart Adequate security levels

Exclusion Criteria:

Camps closer than 5km from a camp included in the study Camps with no previously recorded cases of cutaneous leishmaniasis Displaced communities living outside of defined camp settings

Primary outcomes:
measure: Epidemiological outcome: cutaneous leishmaniasis incidence
timeFrame: 11 or 9 months
measure: Entomological outcome: phlebotomine sandfly density
timeFrame: 9 months
Secondary outcomes:
measure: Intervention feasibility, acceptability and uptake
timeFrame: 11 months
Other outcomes:
Locations:
city: Ar-Raqqa
country: Syrian Arab Republic
facility: The MENTOR Initiative, North East Syria
Study officials:
affiliation: The Mentor Initiative
name: Richard J Allan, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01048840: Natural History of Gastroesophageal Reflux (GER) in Children < 12 Years of Age
Official title: The Natural History of Children With Gastroesophageal Reflux Disease (Ages 15 Months to 11 Years)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Gastroesophageal Reflux
Keywords: Gastroesophageal Reflux
Lead sponsor: Massachusetts General Hospital
Sponsor class: OTHER
Collaborators: name: Takeda Pharmaceuticals North America, Inc.
First posted: 2010-01-14
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The subjects will be selected from a database of patients seen at Children's Hospital, Boston or Massachusetts General Hospital between 1977 and 1990 who had biopsies or pH probe for symptoms of GERD.

Brief summary: The goal of this project is to determine the long-term health outcome of children diagnosed with gastroesophageal reflux (GER). We are inviting subjects that were previously followed in the Pediatric GI programs at Massachusetts General and Children's Hospital, Boston. We have compiled a database of more than 200 subjects that completed diagnostic testing for GER in the 1970's and 1980's. Subjects are being contacted initially by mail using a previously approved recruitment letter. Subjects that fail to respond to this recruitment letter are called by phone. In each case, contact information has been abstracted from the Children's Hospital database. Subjects are then given the opportunity to complete a questionnaire either by phone or in hard copy. Subjects receive no compensation for their participation in this study. Subjects will be compared to controls. Controls will complete the same questionnaire as the subjects. Inclusion of potential controls will be determined by a lack of medical history of gastroenterological diseases before the age of 21 and whether the potential control was born within a year of a subject in the study. Controls will receive $25 to participate in the study.


Eligibility criteria: Inclusion Criteria for Subjects:

* Patients who were evaluated for GERD at the age of 12-17 years, inclusive at Children's Hospital, Boston or Massachusetts General Hospital
* Positive for GERD per biopsies or pH probe results

Inclusion Criteria for Controls:

* No GI diseases prior to age 21 including, but not limited to reflux, inflammatory bowel disease,Hirschsprung's disease
* Date of birth is within 1 year of a subject's date of birth

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: Children's Hospital
state: Massachusetts
Study officials:
affiliation: Massachusetts General Hospital
name: Harland S Winter, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01020240: Physiotherapy in Postpartum After a Cesarean
Official title: Effectiveness of an Orientation Guide for Puerperal Women After Cesarean.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postpartum Period
Keywords: Immediate puerperium
physiotherapy in postpartum
cesarean complications
Lead sponsor: Sao Marcos University
Sponsor class: OTHER
First posted: 2009-11-25
Enrollment: 45
Sex: FEMALE
Minimum age (years): 15
Maximum age (years): 35
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to promote a prevention of the complications using an elaborate guide effective and easy to understand.

Detailed description: The puerperium consists the period of pregnancy and postpartum cycle that the alterations provoked for pregnancy and delivery on the women organism return to your state before pregnancy. The physiotherapist can follow the puerperium since hospital phase until women has been recovered of pregnancy physiologist alterations.

Eligibility criteria: Inclusion Criteria:

* have between 15 and 35 yeas old
* has realize an emergency or elective cesarean
* being in immediate puerperium and did not have receive any orientation

Exclusion Criteria:

* complications in delivery and postpartum
* complications with the baby
* physicologics disease

Primary outcomes:
measure: Analogic Visual Scale
timeFrame: 6 months
Secondary outcomes:
measure: Analogic Visual Scale
timeFrame: 6 months
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Sepaco Hospital
Study officials:
affiliation: São Marcos University
name: Patricia Batista
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06403540: The Impact of Laparotomy and Analgesia Methods on Diaphragm
Official title: The Impact of Laparotomy and Analgesia Methods on Postoperative Diaphragm Muscle Contraction in Major Abdominal Surgeries.
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Colorectal Neoplasms
Gastrectomy
Lead sponsor: Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Sponsor class: OTHER
First posted: 2024-05-08
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients scheduled for major abdominal surgery due to gastrointestinal tumor

Brief summary: Major abdominal surgeries are traditionally performed via laparotomy. Analgesia is routinely administered during the postoperative period. The goal is to investigate the effects of laparotomy and analgesia methods on diaphragm function.

Detailed description: Laparotomy is typically performed through a midline incision during major abdominal surgeries. Patients have difficulty breathing deeply after surgery, particularly because of pain. Intravenous drug administration, epidural catheter placement, and abdominal plane blocks are common methods of analgesia. In this study, the investigators will measure the diaphragm muscle thickness at the xiphoid level at the anterior axillary line in the supine position in participants who underwent laparotomy before and one hour after the operation, using ultrasonography M mode during inspiration, expiration, and forced inspiration. the investigators will test the effects of analgesia methods on diaphragm contraction in participants undergoing laparotomy.

Eligibility criteria: Inclusion Criteria:

* over 18 years,
* major abdominal surgery cases

Exclusion Criteria:

* body mass index (BMI) \>35 kg/m2
* illiteracy,
* communication issues,
* neuromuscular disorders,
* Advanced chronic respiratory disease,
* Previous abdominal or thoracic surgery

Primary outcomes:
measure: The impact of laparotomy on diaphragm thickness.
timeFrame: Measurement at the 1st postoperative hour
Secondary outcomes:
measure: The effect of analgesia methods on diaphragm thickness in patients undergoing laparoscopic surgery.
timeFrame: Measurement at the 1st postoperative hour
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Prof. Dr. Cemil Taşcıoğlu City Hospital
Study officials:
References:
Clinical trial NCT01579240: Internet Intervention Promotes Physical Activity in Sedentary Older Adults
Official title: Internet Intervention Promotes Physical Activity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise
Sedentary Older Adults
Keywords: physical activity
older adults
Internet
sedentary
multi-week
internet intervention
Lead sponsor: Oregon Center for Applied Science, Inc.
Sponsor class: INDUSTRY
Collaborators: name: National Institute on Aging (NIA)
First posted: 2012-04-17
Enrollment: 368
Sex: ALL
Minimum age (years): 55
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: This study evaluated the efficacy of a 12-week Internet intervention to help sedentary older adults adopt and maintain an exercise regimen. A total of 368 men and women over 55 years of age (x = 60.3; SD 4.9 ) were recruited and screened on line. They randomized into treatment and control groups and assessed at pre-test, 12 weeks, and at six months.

The multivariate model was significant at posttest (p = .001; large effect size) and at six months (p = .001; medium effect size). At posttest, intervention participation showed significant improvement on 13 of 14 outcome measures compared to the control group. At six months, treatment group participants were found to maintain large gains compared to the Ctrl participants on all 14 measures.

Detailed description: Based on the treatment group users self reported fitness level, activity goals, and self-identified barriers to exercise, the program helped users select exercise activities in the areas of endurance, flexibility, strengthening, and balance enhancement. They returned weekly for automated video and text support and education, with the option to change or increase in their exercise plan, and on-going problem solving to overcome barriers to exercise.

Eligibility criteria: Inclusion Criteria:

* \> 54 years of age;
* \< 61 minutes of exercise per week;
* internet connection; email address

Exclusion Criteria:

* too young;
* too active;
* no web access;
* no email

Primary outcomes:
measure: Cardiovascular exercise
timeFrame: Baseline-6 months
Secondary outcomes:
measure: Psycho-social measures (attitudes, knowledge, self efficacy, intentions)
timeFrame: Baseline - 6 months.
Other outcomes:
Locations:
city: Eugene
country: United States
facility: ORCAS
state: Oregon
Study officials:
References:
Clinical trial NCT03444740: Lower Urinary Tract Symptoms in Women and Adjustment Disorder
Official title: Do Women Seeking Medical Assistance for Lower Urinary Tract Symptoms Have a High Prevalence of Adjustment Disorder?A Questionnaire Based Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Lower Urinary Tract Symptoms
Adjustment Disorders
Lead sponsor: Basel Women's University Hospital
Sponsor class: OTHER
First posted: 2018-02-23
Enrollment: 100
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All eligible female patients at first time visits or follow-up visits who present to the uro-gynecology department of the University Hospital of Basel with LUTS (such as incontinence, OAB or recurrent UTIs) will be asked to participate in the study. After counseling and agreement the patients will be asked to sign the informed consent

Brief summary: Our hypothesis that the prevalence of AD in uro-gynecologic patients with LUTS who are seeking medical help for their condition is higher than that of the general population (indicated by high scores at the ADNM-20; score above 48). Taking into consideration that affective disorders, anxiety and depression among patients with LUTS present with a prevalence of 17-23% \[20\] as well as through long personal experience, we hypothesize that the prevalence of AD in this group is 20%.


Eligibility criteria: Inclusion Criteria:

* Female patients seeking medical help for lower urinary tract symptoms
* German speaking

Exclusion Criteria:

* Pelvic floor Prolapse symptoms or Stage III or more by medical examination
* Inability to understand the purpose of the study

Primary outcomes:
measure: Prevalence of adjustment disorders among women with lower urinyry tract symptoms
timeFrame: 9 Months
Secondary outcomes:
measure: Correlation between ICIQ-FLUTS and ADNM-20 scores
timeFrame: 9 Months
Other outcomes:
Locations:
Study officials:
References: