louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06236074: Comparison of Modified Post-Anesthetic Discharge Scoring System (PADSS) Between 4 and 24 Hours in Patients Undergoing Laparoscopic Cholecystectomy
Official title: Comparison of Modified Post-Anesthetic Discharge Scoring System (PADSS) Between 4 and 24 Hours in Patients Undergoing Laparoscopic Cholecystectomy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Laparoscopic Cholecystectomy
Lead sponsor: Thammasat University Hospital
Sponsor class: OTHER
First posted: 2024-02-01
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: This study is compare of Modified Post-Anesthetic Discharge Scoring System (PADSS) between 4 and 24 hours in patients undergoing laparoscopic cholecystectomy


Eligibility criteria: Inclusion Criteria:

* Patient undergoing laparoscopic cholecystectomy
* 20-60 years old
* American Society of. Anesthesiologist physical status classification I-III

Exclusion Criteria:

* Turn to open cholecystectomy

Primary outcomes:
measure: Comparison of Modified Post-Anesthetic Discharge Scoring System (PADSS) Between 4 and 24 Hours in Patients Undergoing Laparoscopic Cholecystectomy
timeFrame: 4 vs 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Pathum Thani
country: Thailand
facility: Thammasat University hospital
state: Klongluang
Study officials:
References:
Clinical trial NCT03213574: Impact of GDT in Robot-assisted Laparoscopic Urological Surgery for Low to Moderate Risk Patients
Official title: Impact of Goal Directed Fluid Therapy in Robot-assisted Laparoscopic Urological Surgery for Low to Moderate Risk Patients
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Vascular Hypotension
Hypovolemia
Hypervolemia
Keywords: Goal directed fluid therapy
Lead sponsor: Loma Linda University
Sponsor class: OTHER
First posted: 2017-07-11
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Robot assisted urological procedures are often long surgical cases that can potentially result in complicated postoperative hospital course. The amount of intravenous (IV) fluids administered to patients during these operations fluctuates based on the length of the case, surgical blood loss, hemodynamic monitors, and the discretion of the anesthesiologist. The goal of intraoperative fluid therapy is to maintain optimal tissue perfusion without causing fluid overload. We plan to use a goal directed fluid therapy protocol to optimize fluid status and analyze post-operative outcomes.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing robot-assisted laparoscopic urological procedures in which the patient would have an arterial catheter placed as part of their routine inoperative anesthetic management

Exclusion Criteria:

* Age less than 18;
* current pregnancy;
* history of congestive heart failure, arrhythmias, coagulopathy, cerebral vascular disease , COPD, significant liver or renal impairment, required FloTrac per treating anesthesiologist;
* patient refusal to consent

Primary outcomes:
measure: Postoperative ileus
timeFrame: Up to 3 weeks postoperatively
Secondary outcomes:
measure: Acute kidney injury
timeFrame: Up to 3 weeks postoperatively
measure: Respiratory compromise
timeFrame: Up to 3 weeks postoperatively
measure: Need for diuresis
timeFrame: Up to 3 weeks postoperatively
measure: Hospital length of stay
timeFrame: Up to 4 weeks postoperatively
Other outcomes:
Locations:
city: Loma Linda
country: United States
facility: Loma Linda University
state: California
Study officials:
References:
Clinical trial NCT03560674: Evaluation of Intern Dentists in Emergency Management of Traumatic Dental Injuries in Primary Anterior Teeth
Official title: Evaluation of Knowledge- Attitude- Practice (KAP) of Intern Dentists in Emergency Management of Traumatic Dental Injuries in Primary Anterior Teeth: A Cross-sectional Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Traumatic Injury
Keywords: Dental trauma
emergency management
traumatic injures.
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2018-06-18
Enrollment: 500
Sex: ALL
Minimum age (years): 22
Maximum age (years): 23
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Dentists attending their internship in Cairo University and another private university (Modern Science and Arts University- MSA).

Brief summary: This study aim to evaluate knowledge, attitude, and practice of intern dentistry in emergency management of traumatic dental injures in primary anterior teeth in children aged from 3-5 years old. Questionnaire survey will be designed to evaluate Knowledge - Attitude - and practice of intern dentists who met the eligibility criteria

Detailed description: Questionnaire survey will be designed to evaluate Knowledge - Attitude - and practice of intern dentists toward different forms of traumatic dental injuries in primary anterior teeth in children aged from 3 to 5 years old.

Eligibility criteria: Inclusion Criteria:

* Intern dentists attending their internship in Faculty of Dentistry- Cairo University, other private university (Modern Science and Arts University- MSA).
* The intern dentists who agree to participate.
* Intern dentists who did not attend Pediatric Dentistry round, Endodontic round, Emergency round and Surgery round at Cairo University.
* Intern dentists irrespective of age and sex.

Primary outcomes:
measure: Knowledge, attitude and practice (KAP) of intern dentists
timeFrame: 1 year
measure: Knowledge, attitude and practice (KAP) of intern dentists
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo university
Study officials:
affiliation: Cairo University
name: Hassan Ahmed
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02354274: Novel Approach to Radiotherapy in Locally Advanced Lung Cancer Concomitant Navelbine®
Official title: Novel Approach to Radiotherapy in Locally Advanced Lung Cancer - Heterogeneous FDG-guided Dose Escalation With Concomitant Navelbine®
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: NSCLC
Lead sponsor: Odense University Hospital
Sponsor class: OTHER
Collaborators: name: Odense University Hospital
name: Aarhus University Hospital
name: Rigshospitalet, Denmark
name: Vejle Hospital
name: Naestved Hospital
name: Aalborg University Hospital
name: Herlev Hospital
First posted: 2015-02-03
Enrollment: 330
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To investigate the effect of escalation of radiation dose to tumor and lymph nodes based on an inhomogeneous dose distribution controlled by FDG-PET positive areas compared to a standard homogeneous dose spread

Detailed description: To investigate the effect of escalation of radiation dose to tumor and lymph nodes based on an inhomogeneous dose distribution controlled by FDG-PET-positive areas compared to a standard homogeneous dose spread.

Eligibility criteria: Inclusion Criteria:

* Patients with histologically or cytologically proven locally advanced NSCLC stage IIB to IIIB
* Performance status 0-1
* Able to comply with treatment and follow study and follow-up procedures
* Women must have negative pregnancy test
* Signed, informed consent
* Plan for radiotherapy with conventional 66 Gy/ 33 F, which meets all dosing limits two normal tissue must be available

Exclusion Criteria:

* Any unstable systemic disorder (including infection , unstable angina, congestive heart failure , severe liver , kidney or metabolic disease)
* Need for nasal oxygen
* Former thoracic radiotherapy, unless there is no significant overlap with previous fields
* Any other active malignant disease
* Unable to take oral medications or needing intravenous nutrition
* Ulcer
* Nursing women

Primary outcomes:
measure: Locoregional control (Tumor recurrency is assessed by scheduled CT (of the thorax and upper abdomen)
timeFrame: 5-7 years
Secondary outcomes:
measure: Toxicity (graded after CTCAE 4.0 assessed by physician)
timeFrame: 10 years
measure: Survival
timeFrame: 15 years
measure: Progression free survival
timeFrame: 15 years
Other outcomes:
Locations:
city: Aalborg
country: Denmark
facility: Aalborg University Hospital
city: Aarhus
country: Denmark
facility: Aarhus University Hospital
city: Copenhagen
country: Denmark
facility: Rigshospitalet
city: Herlev
country: Denmark
facility: Herlev University Hospital
city: Naestved
country: Denmark
facility: Department of Oncology, Naestved Hospital
city: Odense
country: Denmark
facility: Department of Oncology, Odense University Hospital
city: Vejle
country: Denmark
facility: Department of Oncology, Vejle Hospital
Study officials:
References:
Clinical trial NCT00790465: Efficacy of Dark Chocolate in Achalasia Patients
Official title: Efficacy of Dark Chocolate in Achalasia Patients: Placebo-Controlled Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
PHASE2
Conditions: Achalasia
Keywords: achalasia
lower esophageal sphincter
nitric oxide
dark chocolate
flavanols
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
First posted: 2008-11-13
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Flavanols, present in dark chocolate, were shown to induce Nitric Oxide synthesis. Since Nitric Oxide facilitates smooth muscle relaxation, it might ease the relaxation of the LES (lower esophageal sphincter)as well.

The objective of the present study is to evaluate tha efficacy of dark chocolate in improving LES relaxation in achalasia patients.


Eligibility criteria: Inclusion Criteria:

* clinical diagnosis of "achalasia"
* "Achalasia" diagnosis during manometry at day 1 of the study.

Exclusion Criteria:

* pregnancy
* pseudoachalasia
* consumption of GI-motility modifiers durin 72 hours preceding the study.

Primary outcomes:
measure: Lower Esophageal Sphincter relaxation before and after dark chocolate consumption.
timeFrame: day 1
Secondary outcomes:
measure: achalasia symptoms before and during dark-chocolate consumption
timeFrame: 2 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05153265: The CIA Score: a Learner's Tool
Official title: Critical, Intervention, Assess: Using the CIA System as a Learning Tool to Assess Bleeding Risk in Regional Anesthesia.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anesthesia, Local
Keywords: regional anesthesia
peripheral nerve block
acute pain medicine
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2021-12-10
Enrollment: 69
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Stanford Regional Anesthesia attending physicians and residents

Brief summary: The goal of this project is to use a previously described scoring system - the CIA system - as a teaching tool to help learners assess the bleeding risk of peripheral nerve blocks. We will teach the CIA system to residents, then they will complete a survey in which they apply the system to various peripheral nerve blocks. We hypothesize that the CIA system will allow learners to reach the same consensus about bleeding risk as expert opinions.

Detailed description: Prior survey of Stanford and Palo Alto VA regional anesthesiologists showed diverging assessments of whether various blocks are considered superficial or deep. Investigators hope to have a simple systematic approach to "scoring" regional anesthesia procedures which can be used as a basis for discussion and comparison of regional expert's opinions.

A scoring system using three categories of consideration to classify any regional procedure is proposed. The following three categories, Critical, Intervention, and Assess (CIA) can be used to analyze any procedure to determine bleeding risk. A score of 0 or 1, was given to each parameter depending on whether it was absent or present. A total score can be range from 0 to 3. From this, the risk can be categorized based on the total score as low-risk (0), intermediate-risk (1) or high-risk (2 or 3).

Eligibility criteria: Inclusion Criteria:

* Regional Anesthesiologist and interested staff from Stanford

Exclusion Criteria:

* Non-regional anesthesiologists and non-interested staff at Stanford

Primary outcomes:
measure: CIA score by trainees
timeFrame: 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University
state: California
Study officials:
References:
citation: Tsui BCH, Kirkham K, Kwofie MK, Tran Q, Wong P, Chin KJ, Sondekoppam RV. Practice advisory on the bleeding risks for peripheral nerve and interfascial plane blockade: evidence review and expert consensus. Can J Anaesth. 2019 Nov;66(11):1356-1384. doi: 10.1007/s12630-019-01466-w. Epub 2019 Aug 26.
citation: Tsui BCH. A systematic approach to scoring bleeding risk in regional anesthesia procedures. J Clin Anesth. 2018 Sep;49:69-70. doi: 10.1016/j.jclinane.2018.06.011. Epub 2018 Jun 15. No abstract available.
Clinical trial NCT03707665: Deep Venous Thrombosis Screening in the ICU by Nurses
Official title: Screening Ultrasound Compression Testing in Critically Ill Patients Performed by General Nurses - Validation Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Deep Venous Thrombosis
Keywords: Compression Ultrasound testing
Nurse
Lead sponsor: Emergency Medical Service of the Central Bohemian Region, Czech Republic
Sponsor class: OTHER
Collaborators: name: Masaryk Hospital Usti nad Labem
First posted: 2018-10-16
Enrollment: 115
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: ICU patients

Brief summary: Despite of preventive measures, the incidence of deep venous thrombosis (DVT) in ICU patients is estimated to range from 5-31%. While clinical diagnostics is unreliable, ultrasound compression test (UCT) has proven to be a highly sensitive and specific modality for the recognition of lower extremity DVT. Delegating this competence to ICU nurses can increase UCT availability and enable preventive DVT screening. Therefore, the investigators decided to conduct a clinical study to evaluate the sensitivity and specificity of UCT performed by general ICU nurse in ICU patients compared to an investigation by ICU physician certified in ultrasound. Prior to the study, each nurse-investigator participating in the study undergo one-hour training in UCT and examine 5 patients under supervision. Then, ICU patients without known DVT will be investigated by UCT in the femoral and popliteal region of both lower extremities by trained general ICU nurse-investigators. On the same day, the examination will be repeated by an ICU physician-investigator. The results of the examinations of each patient will be blinded to each other for both investigators until both tests are performed. The sensitivity and specificity of the test performed by general nurse will be calculated in comparison with the examination by a specialist.


Eligibility criteria: Inclusion Criteria:

* all ICU patients without known deep venous thrombosis, hospitalised more than 72 hours

Exclusion Criteria:

* contraindication of compression ultrasound testing
* end-of-life decision regimen of care

Primary outcomes:
measure: Validity of the compression ultrasound testing in the ICU patients performed by general nurses
timeFrame: One day
Secondary outcomes:
Other outcomes:
Locations:
city: Beroun
country: Czechia
facility: Emergency Medical Service of the Central Bohemian Region
state: Central Bohemian Region
Study officials:
affiliation: Department of Anesthesiology, Perioperative Medicine and Intensive Care, J.E. Purkinje University, Masaryk Hospital Usti nad Labem, Usti nad Labem, Czech Republic
name: Roman Skulec, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02096965: Use of Tolvaptan to Reduce Urinary Supersaturation: a Pilot Proof of Principle Study
Official title: Use of Tolvaptan to Reduce Urinary Supersaturation: a Pilot Proof of Principle Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Nephrolithiasis, Calcium Oxalate
Nephrolithiasis, Calcium Phosphate
Keywords: Calcium oxalate
Calcium phosphate
Kidney stone
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2014-03-26
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: In this study the investigators propose to use a daily dose of 45 mg (30 mg at 8 AM and 15 mg at 4 PM). This relatively small well-tolerated dose is likely to persistently increase urine volume and reduce urine supersaturation and to be well tolerated by patients with kidney stone disease and normal renal function (see below). The twice-daily (8 AM and 4 PM) regimen is designed to produce a maximal AVP inhibition on waking with a gradual fall-off of effect during the night. To this end, a higher dose is used in the morning, with a lower dose in the afternoon.


Eligibility criteria: Inclusion Criteria:

* History of calcium oxalate or calcium phosphate stone.
* Good renal function

Exclusion Criteria:

* History of hypo-or hypernatremia.
* History of hypotension or orthostatic dizziness.
* Clinical history of congestive heart failure.

Primary outcomes:
measure: Change in urinary calcium oxalate supersaturation (SS)
timeFrame: Baseline to 3 weeks
measure: Change in Calcium phosphate SS
timeFrame: Baseline to three weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: John Lieske, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03277365: MyGeneRank: A Digital Platform for Next-Generation Genetic Studies
Official title: MyGeneRank: A Digital Platform for Next-Generation Genetic Studies
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Heart Diseases
Lead sponsor: Scripps Translational Science Institute
Sponsor class: OTHER
First posted: 2017-09-11
Enrollment: 100000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Many conditions affecting health are caused by a combination of environment, behaviors, and genes. While individuals can alter some factors in their lives to reduce the chances of developing different diseases (e.g., not smoking cigarettes), the contribution from genetic risk encoded by DNA remains with people throughout their lives. Scientists are still trying to determine the entirety of genetic factors that influence disease, but for some conditions it has been shown that the factors identified thus far can begin to identify people at high to low genetic risk. Looking across the genome, scientists can calculate a cumulative genetic risk score - which can be used to rank genetic risk compared to other worldwide populations.

The goal of this study is to determine how genetic risk influences health decisions and other things that can be controlled in life. The first genetic risk score is calculated for coronary heart disease (CAD). CAD ultimately leads to heart attacks, heart failure and sometimes sudden cardiac death and is the main reason heart disease remains as the number one cause of death worldwide. Other researchers have shown that this genetic risk score can be used to identify people with low, intermediate, and high risk for coronary heart disease. It has also been shown that the use of statins (cholesterol lowering drugs) provides greater benefit and protection against heart attack for people with high genetic risk for coronary artery disease.

Leveraging the Apple ResearchKit and the ResearchKit linked 23andMe API, customers of 23andMe are able to provide researchers access to their genomic data. Participants will use the ResearchKit app to provide consent, view study information, answer surveys, and contact the study team.

Participants will be asked to complete 3 surveys. One before viewing genetic risk scores, one immediately after viewing scores, and one 6 months after viewing scores.


Eligibility criteria: Inclusion Criteria:

* Customer of 23andMe willing to share their 23andMe data
* User of Apple mobile device

Exclusion Criteria:

* Under 18 years old

Primary outcomes:
measure: Initiation of Statin Therapy
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: La Jolla
country: United States
facility: Scripps Translational Science Institute
state: California
Study officials:
References:
Clinical trial NCT02771665: Mammographic Density and the Risk of Tumor Recurrence in Asian Women: a Case-control Study
Official title: Mammographic Density and the Risk of Tumor Recurrence in Asian Women: a Case-control Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Case Control Study
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2016-05-13
Enrollment: 300
Sex: FEMALE
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women diagnosed with invasive breast cancer who had undergone surgery between 2004 and 2009

Brief summary: To evaluate the influence of mammographic breast density at diagnosis on the risk of cancer recurrence and survival outcome in patients with invasive breast cancer after surgery


Eligibility criteria: Inclusion Criteria:

* Women diagnosed with invasive breast cancer between 2004 and 2009 who had undergone surgery and had the mammographic breast density ascertained before, or at, diagnosis.

Exclusion Criteria:

* Women diagnosed with invasive breast cancer between 2004 and 2009 who had not undergone surgery or who had no mammographic breast density ascertained before, or at, diagnosis.

Primary outcomes:
measure: Hazard ratios for recurrence
timeFrame: 2004 to 2009
Secondary outcomes:
measure: Hazard ratios for death
timeFrame: 2004 to 2009
Other outcomes:
Locations:
Study officials:
affiliation: National Taiwan University Hospital
name: Jenny Ling-Yu Chen, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Huang YS, Chen JL, Huang CS, Kuo SH, Jaw FS, Tseng YH, Ko WC, Chang YC. High mammographic breast density predicts locoregional recurrence after modified radical mastectomy for invasive breast cancer: a case-control study. Breast Cancer Res. 2016 Dec 1;18(1):120. doi: 10.1186/s13058-016-0784-3.