Clinical trial NCT06825767: Comparison of the Effectiveness of High-Intensity and Low-Intensity Laser Therapies in Primary Knee Osteoarthritis
Official title: Comparison of the Effectiveness of High-Intensity and Low-Intensity Laser Therapies in Primary Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Primary Knee Osteoarthritis
Keywords: Osteoarthritis, Low level light therapy, high level light therapy,Muscle Skeletal; Ultrasonography
Lead sponsor: Ankara City Hospital Bilkent
Sponsor class: OTHER
First posted: 2025-02-13
Enrollment: 72
Sex: ALL
Minimum age (years): 55
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Our primary goal is to investigate the advantages of low-intensity laser therapy (LLLT) and high-intensity laser therapy (HILT) over conventional therapy in patients with knee osteoarthritis (OA), our secondary goal is to investigate the advantages of HILT and LLLT; to compare its analgesic effects, its effects on functional status and quality of life, and its effects on femoral cartilage thickness.

Detailed description: In the study, those who applied to Ankara City Hospital Physical Therapy and Rehabilitation Hospital outpatient clinic between 01.10.2020-01.10.2021, were between the ages of 55-75, were diagnosed with primary knee OA according to the American Rheumatology Association, stage 2-3 knee according to Kellgren and Lawrence radiological classification. with OA; 72 volunteer patients with knee pain with a visual pain score of 4 and above for at least 3 months were included. The study was designed as a prospective, randomized, controlled, single-center. Patients were randomly divided into 3 treatment groups. Conventional treatment including hotpack therapy, Transcutaneous Electrical Nerve Stimulation (TENS), joint range of motion exercises, straight leg lifting exercises, quadriceps strengthening exercises, pillow squeezing exercises, balance exercises on one leg for 4 weeks, 3 days a week for 4 weeks in 24 patients in the first group, conventional treatment and HILT were applied to 24 patients in the second group, and conventional treatment and LLLT were applied to 24 patients in the third group. All groups were evaluated clinically and ultrasonographically at the beginning of the treatment, at the end of the treatment and at the 3rd month after the treatment.

Eligibility criteria: Inclusion Criteria:

* Age range of 55-75 years
* Primary knee OA diagnosis according to ACR (American College of Rheumatology) and Knee OA classified as stage 2-3 according to the KL (Kellgren-Lawrence) radiological classification
* Visual pain score of 4 or higher for knee pain lasting for at least 3 months

Exclusion Criteria:

* Patients with secondary knee OA
* Patients who have undergone surgical operations related to the knee joint
* Patients with pathology in the hip and/or ankle on the same side
* Patients who have received intra-articular corticosteroid, hyaluronic acid, or PRP injections in the knee joint in the last 6 months
* Patients who have received physical therapy for the knee region in the last 6 months
* Patients with serious systemic diseases such as malignancy, congestive heart failure, or chronic obstructive pulmonary disease
* Patients with insufficient cognitive function

Primary outcomes:
measure: range of motion
timeFrame: Baseline, after 1 month and 3 month changes
measure: visual pain score (VAS)
timeFrame: Baseline, after 1 month and 3 month changes
Secondary outcomes:
measure: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
timeFrame: Baseline, after 1 month and 3 month changes
measure: Lequesne Index
timeFrame: Baseline, after 1 month and 3 month changes
measure: Short form SF-36 scale
timeFrame: Baseline, after 1 month and 3 month changes
measure: Femoral cartilage thickness
timeFrame: Baseline, after 1 month and 3 month changes
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara Bilkent City Hospital Phisical Therapy and Rehabilitation Hospital
state: Bilkent-Cankaya
Study officials:
References: