louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02834962: Study of Single And Double Bundle Anterior Cruciate Ligament (ACL) Graft Cross-sectional Dimensions
Official title: Study of Single And Double Bundle ACL Graft Cross-sectional Dimensions Compared With Native ACL
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Rupture of Anterior Cruciate Ligament
Keywords: Anterior Cruciate Ligament Reconstruction
Lead sponsor: Peking University Third Hospital
Sponsor class: OTHER
First posted: 2016-07-15
Enrollment: 100
Sex: ALL
Minimum age (years): 10
Maximum age (years): 50
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To study the difference between single and double bundle ACL graft cross-sectional dimensions compared with native ACL using postoperative 3-D MRI.

Detailed description: The investigators divide 100 patients with ACL rupture into 2 groups. Group A undergo single bundle anterior cruciate ligament reconstruction (ACLR). Group B undergo double bundle ACL reconstruction. At 3-6 weeks post operation, all the patients undergo 3-D MRI examination of both knees. The investigators reconstruct 3-D models of reconstructed ACL and native ACL, and compare the difference between single and double bundle graft.

Eligibility criteria: Inclusion Criteria:

* ACL rupture patients aged between 10 to 50 years

Exclusion Criteria:

* combined severe injuries to the operated knee (additional ligament rupture, major meniscus loss, patella instability, cartilage damage \>2°, pathologic leg axis deviation)
* any injury or surgery to the contralateral knee
* any inflammatory or systemic disease, neuromuscular disease in the lower limbs,any recent knee infection

Primary outcomes:
measure: cross-sectional area of the reconstructed ACL
timeFrame: 3-6 weeks
measure: long to short axis ratio of the cross-sectional area of the reconstructed ACL
timeFrame: 3-6 weeks
measure: long axis of the cross-sectional area of the reconstructed ACL
timeFrame: 3-6 weeks
measure: short axis of the cross-sectional area of the reconstructed ACL
timeFrame: 3-6 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Peking University Third Hospital
name: Jia-Kuo Yu
role: STUDY_CHAIR
References:
Clinical trial NCT06186362: Results of Distal Clavicle Graft in Shoulder Dislocation Clavicle Auto Graft in Patient With Recurrent Anterior Shoulder Dislocation
Official title: Clinical and Radiological Results of Distal Clavicle Auto Graft in Patient With Recurrent Anterior Shoulder Dislocation
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Shoulder Injuries
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2024-01-02
Enrollment: 30
Sex: ALL
Minimum age (years): 15
Maximum age (years): 55
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Range of motion "ROM" (Forward flexion, external rotation, internal rotation) Preoperative and postoperative ROM . Rowe score, Visual analogue score (VAS). Secondary outcomes postoperative complications will be evaluated.

Brief summary: to evaluate the clinical and radiological Outcome of Distal Clavicle Auto graft in patient with recurrent Shoulder dislocation

Detailed description: The glenohumeral joint is the most commonly dislocated joint of the human body,The stability of GH joint relies on a complex network of static and dynamic structures,The anterior labrum plays a key role in antero posterior stability as it deepens the glenoid cavity up to 50% There option for glenoid reconstruction including: Distal Clavicle Auto graft (DCA), proven is a good option to coracoid transfers

Eligibility criteria: Inclusion Criteria:

* Recurrent Traumatic anterior shoulder dislocation (≥ 3 times).

Exclusion Criteria:

.On-track Hill-Sachs lesion. .Multi directional instability.

* Voluntary dislocation.

Primary outcomes:
measure: Row score
timeFrame: At 2 months, 6 months post operative
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Kane P, Bifano SM, Dodson CC, Freedman KB. Approach to the treatment of primary anterior shoulder dislocation: A review. Phys Sportsmed. 2015 Feb;43(1):54-64. doi: 10.1080/00913847.2015.1001713. Epub 2015 Jan 6.
Clinical trial NCT03016962: Usefulness of Cap-assisted Colonoscopy in Patients With Prior Abdominal Surgery
Official title: Usefulness of Cap-assisted Colonoscopy in Patients With Prior Abdominal Surgery: A Randomized, Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Insertion Time
Lead sponsor: The Catholic University of Korea
Sponsor class: OTHER
First posted: 2017-01-11
Enrollment: 1046
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: The potential benefit of using the cap is that it helps in luminal orientation at bends by keeping the colonic mucosa away from the lens at the colonoscope tip. Colonoscopy in patients with a history of abdominal surgery is considered to be difficult due to adhesion-related bowel angulations. There were few study evaluating usefulness of cap-assisted colonoscopy in patients with prior abdominal surgery. The investigators designed a randomized, controlled trial to verify the usefulness of cap-assisted colonoscopy in patients with prior abdominal surgery.

Detailed description: The potential benefit of using the cap is that it helps in luminal orientation at bends by keeping the colonic mucosa away from the lens at the colonoscope tip. This assists in negotiating sharp turns by better anticipation of the direction. Cap-assisted colonoscopy can be tried as a salvage procedure in cases of failed cecal intubation with regular colonoscopy. Colonoscopy in patients with a history of abdominal surgery is considered to be difficult due to adhesion-related bowel angulations. There were few study evaluating usefulness of cap-assisted colonoscopy in patients with prior abdominal surgery. The investigators designed a randomized, controlled trial to verify the usefulness of cap-assisted colonoscopy in patients with prior abdominal surgery.

Eligibility criteria: Inclusion Criteria:

* Patients with history of abdominal or pelvic surgery

Exclusion Criteria:

* Previous colorectal resection

Primary outcomes:
measure: Insertion time
timeFrame: Day 1
Secondary outcomes:
measure: Patient discomfort
timeFrame: Day 1
measure: Overall technical ease
timeFrame: Day 1
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04991662: Effect of Three Weight-adjusted Vasopressors for Elective Cesarean Delivery
Official title: Effect of Three Weight-adjusted Vasopressors for With Combined Spinal-Epidural Anesthesia for Elective Cesarean Delivery: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Cesarean Section Complications
Lead sponsor: Xuzhou Medical University
Sponsor class: OTHER
First posted: 2021-08-05
Enrollment: 78
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study compared the effects of prophylactic infusion of metaraminol, phenylephrine and norepinephrine adjusted according to body weight on fetal acid-base balance and maternal hemodynamics.

Detailed description: At present, the ED90 of metaraminol, phenylephrine, and norepinephrine in the prevention of cesarean section hypotension has been explored. We compare the effects of three drugs on the fetus and mothers at the concentration of ED90 to provide advice on the use of vasoactive drugs for obstetrics anesthesia .

Eligibility criteria: Inclusion Criteria:

1. Singleton pregnancy at term scheduled to be delivered via elective cesarean delivery;
2. height 150-180 cm;
3. American Society of Anesthesiologists (ASA) physical status II-III;
4. body mass index (BMI) \<35 kg/m2.

Exclusion Criteria:

1. transverse presentation, fetal macrosomia;
2. uterine abnormalities (eg, large fibroids, bicornuate uterus);
3. polyhydramnios;
4. ruptured membranes, oligohydramnios;
5. intrauterine growth restriction;
6. gestational or nongestational hypertension, diabetes, or eclampsia;
7. hypertensive disorders or any condition associated with autonomic neuropathy (such as diabetes mellitus for \>10 years) or renal failure;
8. contraindications for combined spinal-epidural anesthesia;
9. participants who declined to sign informed consent forms.

Primary outcomes:
measure: Umbilical artery blood pH
timeFrame: 30 seconds after delivery
Secondary outcomes:
measure: hypotension
timeFrame: Intraoperative
measure: bradycardia
timeFrame: Intraoperative
measure: The incidence of nausea in pregnant women
timeFrame: Intraoperative
measure: Umbilical artery blood base excess
timeFrame: 30sec after delivery
measure: The incidence of vomiting in pregnant women
timeFrame: Intraoperative
Other outcomes:
Locations:
city: Peking
country: China
facility: Department of Anesthesiology and Operating Room, Affiliated Hospital of Peking University People's Hospital
state: Beijing
Study officials:
affiliation: Peking University People's Hospital
name: Feng Yi, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00804362: Validation of the Sickle Cell Disease Pain Burden Interview
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sickle Cell Disease
Pain
Lead sponsor: Connecticut Children's Medical Center
Sponsor class: OTHER
First posted: 2008-12-08
Enrollment: 131
Sex: ALL
Minimum age (years): 7
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children and adolescents diagnosed with sickle cell disease.

Brief summary: The purpose of this study is to validate a brief survey tool, the SCD Pain Burden Interview (SCPBI), which can be used in the clinical and/or research settings to assess the impact of pain on children with sickle cell disease.


Eligibility criteria: Inclusion Criteria:

* Documented sickle cell disease
* 7 years old or greater
* Primary caregiver present at the first visit for children \< 18 years of age

Exclusion Criteria:

* Primary language spoken other than English
* Patient is in acute pain episode at time of initial visit

Primary outcomes:
measure: Correlation with validated measures of pain interference, function, quality of life, and mood.
timeFrame: Quarterly
Secondary outcomes:
Other outcomes:
Locations:
city: Hartford
country: United States
facility: Connecticut Children's Medical Center
state: Connecticut
Study officials:
References:
Clinical trial NCT03427762: Compare the Effects of Agility and Cycling Exercise Training on Mobility and Balance in PD and Healthy Old Adults
Official title: Compare the Effects of Agility and Cycling Exercise Training on Mobility and Balance in PD and Healthy Old Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Movement Disorders
Parkinson Disease
Condition
Keywords: balance
postural controll
motor controll
posturgraphy
quality of life
Lead sponsor: Somogy Megyei Kaposi Mór Teaching Hospital
Sponsor class: OTHER
Collaborators: name: University of Groningen
First posted: 2018-02-09
Enrollment: 3
Sex: ALL
Minimum age (years): 55
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to compare the effectiveness and specificity of agility and cycling exercise training on balance and mobility outcomes in PD and age and gender matched healthy controls. The hypothesis is that due to being profoundly deconditioned, agility and cycling will be similarly effective in PD but agility will be more effective then cycling in healthy old adults, in improving mobility and balance.


Eligibility criteria: Inclusion Criteria:

* family doctor should be qualified as healthy.
* older adults had to have basic fitness
* weekly movement of at least 3 hours

Exclusion Criteria:

* Severe heart problems
* severe demeanor
* alcoholism
* drug problems

Primary outcomes:
measure: Postural instability
timeFrame: 5 weeks
measure: quality of life
timeFrame: 5 weeks
measure: balance test
timeFrame: 5 weeks
measure: mobility test
timeFrame: 5 weeks
Secondary outcomes:
measure: depression scale
timeFrame: 5 weeks
Other outcomes:
Locations:
city: Kaposvár
country: Hungary
facility: József Tollár
state: Somogy
Study officials:
affiliation: Somogy Megyei Kaposi Mór Teaching Hospital
name: József Tollár, MSC
role: PRINCIPAL_INVESTIGATOR
References:
citation: Tollar J, Nagy F, Moizs M, Toth BE, Sanders LMJ, Hortobagyi T. Diverse Exercises Similarly Reduce Older Adults' Mobility Limitations. Med Sci Sports Exerc. 2019 Sep;51(9):1809-1816. doi: 10.1249/MSS.0000000000002001.
Clinical trial NCT05887362: The Power of Hand Reflexology in Ameliorating Anxiety, Pain, and Fatigue Among Patients Undergoing Coronary Angiography
Official title: The Power of Hand Reflexology in Ameliorating Anxiety, Pain, and Fatigue Among Patients Undergoing Coronary Angiography
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Coronary Artery Disease
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2023-06-02
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Reflexology influences pain perception and pain-impulse transmission by releasing endorphins (12). Patients with a variety of medical illnesses can benefit from hand reflexology by lessening their physical and emotional discomfort (13, 14). Therefore, this study was done to investigate the power of hand reflexology in ameliorating anxiety, pain, and fatigue among patients undergoing coronary angiography


Eligibility criteria: Criteria:

Inclusion Criteria:

* Patients between the ages of 20 and 60 who were scheduled for non-emergency CA, Absence of any hands' sensory motor disorders, or upper limb vascular injuries.
* No abnormalities such as amputations, burns, skin lesions, and intervertebral disc herniation.
* No history of mental illnesses.

Exclusion Criteria:

Patients with severe mental problems

Primary outcomes:
measure: Pain intensity
timeFrame: 4 months
measure: Fatigue
timeFrame: 4 months
measure: Anxiety
timeFrame: 4 months
Secondary outcomes:
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Faculty of Nursing, Alexandria university
Study officials:
References:
Clinical trial NCT02556762: Simultaneous Modulated Accelerated Boost Versus Standard Dose Radiotherapy in Esophageal Cancer
Official title: Phase III Randomized Controlled Trial of Definite Chemoradiotherapy in Patients With Esophageal Cancer: Simultaneous Modulated Accelerated Boost Versus Standard Dose Radiotherapy
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Esophageal Cancer
Keywords: Esophageal cancer
Simultaneous modulated accelerated boost
Standard dose radiotherapy
Chemotherapy
Survival
Lead sponsor: Shantou University Medical College
Sponsor class: OTHER
First posted: 2015-09-22
Enrollment: 202
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This randomized phase III trial is to compare simultaneous modulated accelerated boost with standard dose radiotherapy given together with chemotherapy in treating patients with esophageal squamous cell carcinoma.


Eligibility criteria: Inclusion Criteria:

* Histologic proof of primary squamous cell carcinoma of the esophagus.
* Primary disease at cervical, upper or middle thoracic esophagus
* T1-4, N any, M0 (except supraclavicular lymph node).
* Age≥18 \& ≤75.
* ECOG score 0-2.
* Platelets ≥ 150,000, Hgb ≥ 10 gm%, ANC ≥ 1500, serum creatinine ≤ 1.5 mg/dl.
* Adequate liver function.
* Patients with prior malignancy are eligible if disease-free ≥ 5 years.
* No prior chest radiotherapy, systemic chemotherapy or major esophageal surgery.
* Signed study-specific informed consent form prior to study entry.

Exclusion Criteria:

* Patients with tracheo-esophageal fistula.
* Patients with invasion into mucosa of trachea or major bronchi.
* Patients with uncontrolled serious medical or mental illnesses.
* Prior RT that would result in overlap of planned RT fields.
* Pregnancy or women of childbearing potential and men who are sexually active
* Women who are breastfeeding a baby.

Primary outcomes:
measure: Overall survival
timeFrame: 2 years
Secondary outcomes:
measure: Local-regional control
timeFrame: 2 years
measure: Distant metastasis-free survival
timeFrame: 2 years
measure: Disease-free survival
timeFrame: 2 years after randomization
measure: Acute and late toxicities using CTCAE v4.0
timeFrame: 2 years
measure: Quality of life as assessed with FACT-E
timeFrame: 2 years
measure: Quality of life as measured with EQ-5D
timeFrame: 2 years
measure: Biomarkers
timeFrame: 2 years
Other outcomes:
Locations:
city: Shantou
country: China
facility: Cancer Hospital, Shantou University Medical College
state: Guangdong
Study officials:
affiliation: Cancer Hospital, Shantou University Medical College
name: Chuangzhen Chen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02100462: Chlorthalidone and HCTZ Impacts on Platelet Activation
Official title: Evaluation of Platelet Effects of Chlorthalidone and Hydrochlorothiazide
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Hypertension
Keywords: Hypertension
Platelet activation
Platelet aggregation
Chlorthalidone
Lead sponsor: Creighton University
Sponsor class: OTHER
Collaborators: name: Dialysis Clinic, Inc.
First posted: 2014-04-01
Enrollment: 30
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: This will be a randomized, double-blinded, three-period crossover study of platelet activation and aggregation in 30 non-smoking healthy volunteers comparing chlorthalidone (CTD), hydrochlorothiazide (HCTZ), and aspirin (ASA; active control). The study hypothesis is that CTD has different effects on platelet activation and aggregation than HCTZ.


Eligibility criteria: Inclusion Criteria:

* Men or women age 19 or older
* Not currently taking any routinely scheduled prescription or over the counter medications or herbal supplements
* No use of aspirin, clopidogrel, prasugrel, ticagrelor, cilostazol, dipyridamole, NSAID medications, or herbal supplements within the previous 7 days and able to refrain from use during the study period
* Systolic blood pressure \> 110 mmHg and diastolic blood pressure \> 60 mmHg
* Non-smoker

Exclusion Criteria:

* Previous adverse reaction or allergy to HCTZ, CTD, or ASA
* Severe sulfonamide hypersensitivity (anaphylaxis or Stevens-Johnson syndrome)
* Diagnosis of any chronic disease or condition
* History of gout or hyperuricemia
* History of pancreatitis
* History of systemic lupus erythematosus (SLE)
* History of hypokalemia requiring treatment
* Pregnant or planning to become pregnant during the study period
* Breastfeeding
* History of hypotension
* History of gastrointestinal bleeding

Primary outcomes:
measure: Change in mean fluorescence intensity of PAC-1
timeFrame: 2 weeks
Secondary outcomes:
measure: Change in CD62P expression
timeFrame: 2 weeks
measure: Change in platelet aggregation
timeFrame: 2 weeks
Other outcomes:
Locations:
city: Omaha
country: United States
facility: Creighton University
state: Nebraska
Study officials:
affiliation: Creighton University
name: Khalid Bashir, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Bashir K, Burns T, Pirruccello SJ, Aurit SJ, Hilleman DE. Comparative antiplatelet effects of chlorthalidone and hydrochlorothiazide. J Clin Hypertens (Greenwich). 2022 Oct;24(10):1310-1315. doi: 10.1111/jch.14564. Epub 2022 Sep 6.
Clinical trial NCT00220662: The Efficacy of Readiness and Motivation Therapy in Individuals With Anorexia Nervosa and Bulimia Nervosa
Official title: The Efficacy of Readiness and Motivation Therapy in Individuals With Anorexia Nervosa and Bulimia Nervosa
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Anorexia Nervosa
Bulimia Nervosa
Keywords: anorexia nervosa
bulimia nervosa
readiness and motivation
Lead sponsor: St. Paul's Hospital, Canada
Sponsor class: OTHER
First posted: 2005-09-22
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This research examines the efficacy of a 5-session individual psychotherapy intervention designed to enhance readiness and motivation for change in individuals with anorexia nervosa, bulimia nervosa, and eating disorder not otherwise specified.

It is hypothesized that individuals randomly assigned to receive Readiness and Motivation Therapy (RMT) will have higher readiness and motivation scores and improved eating disorder and psychiatric symptomatology following the intervention than individuals assigned to a no-treatment control condition.

Detailed description: Readiness and motivation for change is a significant concern in the treatment of individuals with eating disorders, as evidenced by frequent treatment drop-out, refusal, and relapse. This research examines the efficacy of a 5-session intervention designed to enhance readiness and motivation for change in individuals with anorexia nervosa. A manualized treatment protocol of Readiness and Motivation therapy (RMT) has been developed. It is hypothesized that individuals randomly assigned to RMT will have improved readiness and motivation for change as assessed using the Readiness and Motivation Interview (RMI) at post-treatment, 3-month, and one-year follow-up than individuals assigned to a no treatment control condition. If RMT proves to be effective, it could be added to the menu of treatment options, to permit for better tailoring of treatment to client readiness for change.

Eligibility criteria: Inclusion Criteria:

* meet DSM-IV diagnostic criteria for anorexia nervosa, bulimia nervosa, or eating disorder not otherwise specified

Exclusion Criteria:

* acute medical crisis
* acute psychiatric crisis

Primary outcomes:
measure: Readiness and Motivation Scores Post-treatment and at 3-month and one-year follow-up
Secondary outcomes:
measure: Psychiatric and eating disorder symptom severity Post-treatment and at 3-month and one-year follow-up
Other outcomes:
Locations:
city: Vancouver
country: Canada
facility: Eating Disorders Program, St. Paul's Hospital 1081 Burrard St.
state: British Columbia
Study officials:
affiliation: St. Paul's Hospital, Department of Psychiatry/University of British Columbia, Department of Psychiatry
name: Josie Geller, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: