Clinical trial NCT06074172: The Effect of Cannabidiol in Learning and Memory of Adults
Official title: The Effect of Cannabidiol in Learning and Memory of Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Memory
Lead sponsor: Colorado State University
Sponsor class: OTHER
Collaborators: name: Institute of Cannabis Research
First posted: 2023-10-10
Enrollment: 57
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Two-arm Case-Crossover
Primary purpose: TREATMENT

Brief summary: The main objectives of this study were to test if a singular dose of Cannabidiol (1) enhances the learning and memory of healthy human subjects, (2) test if Cannabidiol has negative effects on Retroactive and Proactive Interference during learning, (3) and test if demographic factors will influence CBD's modulation of human learning and memory.

Detailed description: Using a randomized, double-blind, placebo-controlled two-arm case-crossover trial, this study investigates the effect of 246 milligrams (mg) of Cannabidiol (CBD) on the learning and memory scores of human subjects, as well as the effect of Cannabidiol on Proactive and Retroactive Interference. This study also investigated the influence of demographic factors on CBD's modulation of human learning and memory.

This study was conducted at Colorado State University-Pueblo (CSU Pueblo) with volunteers recruited from CSU Pueblo and the local Pueblo community. Fifty-seven subjects were randomized in a double-blind manner to receive either CBD or placebo before completing two versions of learning and memory assessments. Each version of the learning and memory assessment included the Montreal Cognitive Assessment (MOCA), the Rey Auditory Verbal Learning Task-Revised (RAVLT-R), and the Logical Memory Subject of the Weschler Memory Scale. Several components of the RAVLT-R were evaluated including the Sum of Trials (Trials I-V) score, Proactive Interference Ratio (PI Ratio), and Retroactive Interference (RI Ratio).

Eligibility criteria: Inclusion Criteria:

* Were 18 years of age or older

Exclusion Criteria:

* Were pregnant or breast-feeding
* Had been diagnosed with mental illness
* Didn't speak English fluently
* Had severe hearing problems
* Had recreational or opioid drug contaminants in their urine
* Were involved in criminal activity

Primary outcomes:
measure: Sum of Trials (I-V)
timeFrame: Each trial is 45 seconds for encoding and recall
measure: Proactive Interference Ratio (PI Ratio)
timeFrame: Each trial is 45 seconds for encoding and recall
measure: Retroactive Interference Ratio (RI Ratio)
timeFrame: Each trial is 45 seconds for encoding and recall
measure: Total Prose Recall
timeFrame: Each recall takes about 5 min for encoding and recall
measure: Montreal Cognitive Assessment Score
timeFrame: 10 minutes total for encoding and recall
Secondary outcomes:
Other outcomes:
Locations:
city: Pueblo
country: United States
facility: Colorado State University Pueblo
state: Colorado
Study officials:
affiliation: Colorado State University-Pueblo
name: Moussa M Diawara, PhD
role: PRINCIPAL_INVESTIGATOR
References: