Clinical trial NCT04853394: Tajik Migrant Health Education Study
Official title: MASLIHAT Intervention for Tajik Male Migrants Who Inject Drugs
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: HIV Infections
Hepatitis C
Risky Health Behavior
Risk Reduction Behavior
Keywords: injection drug use
migrant workers
risk behavior
Lead sponsor: University of Illinois at Chicago
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
name: Prisma Research Center
First posted: 2021-04-21
Enrollment: 420
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: cluster-randomized parallel groups
Primary purpose: PREVENTION

Brief summary: This study will test the efficacy of a peer-education prevention intervention to reduce risky drug, alcohol, and sexual behaviors among male Tajik labor migrants who inject drugs (MWID) while working in Moscow. The peer educator intervention will be compared to a health education control intervention. Each intervention consists of 5 weekly 2-hour small group sessions. Follow-up assessments will be conducted at 3, 6, 9, and 12 months after the intervention. It is hypothesized that, compared to MWID who receive the health education control intervention, those who receive the peer educator intervention will have a greater reduction in the frequency of risk behaviors. Similar effects are expected for network members of intervention participants.

Detailed description: The investigators will recruit male Tajik migrants who inject drugs from 12 different sites in Moscow, including bazaars and other work sites. In both study arms, the recruited men (index participants) will be required to recruit two eligible MWID peers for interviews prior to being interviewed themselves. Participants will be randomly assigned to either the peer educator intervention program or the health education intervention program. After peer-recruited network members are enrolled and interviewed, the index participant will participate in the peer educator training or the control group activities. All participants and recruited network members will then be followed and re-interviewed at 3-month intervals for one year to assess changes in risky drug, alcohol, and sexual behaviors due to intervention participation and through diffusion to network members. The investigators will also collect data from voluntary HIV and HCV testing conducted at 6 months (HCV only) and at 12 months (HIV and HCV) post-intervention.

Eligibility criteria: Inclusion Criteria:

* adult Tajik man
* injected drugs in past 30 days
* living and working as migrant laborer in Moscow

Exclusion Criteria:

* does not intend to stay in Moscow for the next 12 months

Primary outcomes:
measure: Syringe Sharing
timeFrame: 3 months
measure: Sex Without Condom
timeFrame: 3 months
measure: Alcohol Use
timeFrame: 30 days
Secondary outcomes:
measure: HIV Infection
timeFrame: 12 months
measure: Hepatitis C Infection
timeFrame: 12 months
Other outcomes:
measure: Injection Equipment Sharing
timeFrame: 3 months
Locations:
city: Moscow
country: Russian Federation
facility: PRISMA Research Center
Study officials:
affiliation: University of Illinois at Chicago
name: Mary E Mackesy-Amiti, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Mackesy-Amiti ME, Levy JA, Bahromov M, Jonbekov J, Luc CM. HIV and Hepatitis C Risk among Tajik Migrant Workers Who Inject Drugs in Moscow. Int J Environ Res Public Health. 2023 May 24;20(11):5937. doi: 10.3390/ijerph20115937.
citation: Luc CM, Levy J, Bahromov M, Jonbekov J, Mackesy-Amiti ME. HIV knowledge, self-perception of HIV risk, and sexual risk behaviors among male Tajik labor migrants who inject drugs in Moscow. BMC Public Health. 2024 Jan 11;24(1):156. doi: 10.1186/s12889-023-17543-1.
citation: Mackesy-Amiti ME, Bahromov M, Levy JA, Jonbekov J, Luc CM. Changes in risk behaviour following a network peer education intervention for HIV prevention among male Tajik migrants who inject drugs in Moscow: a cluster-randomized controlled trial. J Int AIDS Soc. 2024 Jul;27 Suppl 3(Suppl 3):e26310. doi: 10.1002/jia2.26310.