louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01872130: Reflectance Confocal Microscopy of Wounds During Moh's Surgery: Feasibility Testing of a Mosaicing Algorithm for Intraoperative Imaging of Cancer Margins
Official title: Reflectance Confocal Microscopy of Wounds During Moh's Surgery: Feasibility Testing of a Mosaicing Algorithm for Intraoperative Imaging of Cancer Margins
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Basal Cell Carcinoma
Squamous Cell Carcinoma
Keywords: Moh's Surgery
mosaicing algorithm
intraoperative imaging
12-239
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
First posted: 2013-06-07
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients in Dermatology clinics at MSKCC

Brief summary: The purpose of this study is to evaluate a new instrument that shines light and takes digital pictures of skin. The goal is to develop a technique that may enable fast and accurate assessment of surgical margins in the excision of basal cell carcinoma (BCC) or squamous cell carcinoma (SCC). The investigators will evaluate the pictures obtained by the confocal microscope to determine whether this technique may be useful in the future for helping Mohs surgeons remove cancers. In the future, patients may benefit with shorter surgery and improved care.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing Mohs surgery for basal cell carcinoma (BCC )or squamous cell carcinoma (SCC). .
* Ability to sign informed consent.
* Age ≥ 18 years.

Exclusion Criteria:

* Mohs surgery located on a site that may not be convenient to confocal imaging.
* Inability to give informed consent.
* Inability to tolerate imaging procedure (i.e., remain relatively still for multiple short durations of 3-4 minutes) over a total time of 20 minutes.

Primary outcomes:
measure: test feasibility of a mosaicing algorithm intraoperative
timeFrame: 1 year
Secondary outcomes:
measure: test feasibility of a mosaicing algorithm preoperative
timeFrame: 1 year
Other outcomes:
Locations:
city: Basking Ridge
country: United States
facility: Memorial Sloan Kettering at Basking Ridge
state: New Jersey
city: Harrison
country: United States
facility: Memorial Sloan Kettering West Harrison
state: New York
city: Hauppauge
country: United States
facility: Memorial Sloan Kettering Cancer Center Hauppauge
state: New York
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: Kishwer Nehal, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04693130: Mindfulness-based Prenatal Education on Women
Official title: Effects of Mindfulness-based Prenatal Education on Biopsychological Health for Prenatal Mental Disorders Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Depression, Anxiety
Lead sponsor: National Taipei University of Nursing and Health Sciences
Sponsor class: OTHER
First posted: 2021-01-05
Enrollment: 102
Sex: FEMALE
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to explore the differences between stress, anxiety, depression, mindfulness, mother and infants bonding, salivary amylase activity, and postnatal maternal outcomes for prenatal mental disorders in women with mindfulness prenatal education program

Detailed description: The aim of this study was to test the efficacy of a Mindfulness prenatal education program in reducing pregnant women's perceived stress, anxiety, depression, mindfulness, mother and infant bonding, and salivary alpha-amylase compared to a control group. The investigators hypothesize that using the mindfulness prenatal education program by the study group will lead to improved related mood symptoms compared with the control group.

Randomized Controlled Trial comparing two education programs with health and singleton pregnant women is run by the Random Allocation Software (Saghaei, 2004). Use the G-Power 3.1.9 windows: repeated measures and between factors among two groups to calculate the number of samples, and setting the power = .8, α = .05, effect size = .25. The estimated number of samples may be lost 30%, total 102 samples.

Eligibility criteria: Inclusion Criteria:

* Subjects were at the age over 20
* Could speak and read Chinese fluently
* Willing and be ale to attend the education program

Exclusion Criteria:

* Taking medication for diagnosing mental illness
* With complicated or high-risk pregnancies

Primary outcomes:
measure: stress
timeFrame: baseline , and at eight weeks (after the intervention), 36 weeks of gestation, and the follow-up at 2 , 4 months postpartum
Secondary outcomes:
measure: depression
timeFrame: baseline , and at eight weeks (after the intervention), 36 weeks of gestation, and the follow-up at 2 , 4 months postpartum
Other outcomes:
measure: mindfulness
timeFrame: baseline , and at eight weeks (after the intervention), 36 weeks of gestation, and the follow-up at 2 , 4 months postpartum
measure: anxiety
timeFrame: baseline , and at eight weeks (after the intervention), 36 weeks of gestation.
measure: bonding
timeFrame: the follow-up at 2 , 4 months postpartum.
Locations:
city: Taipei
country: Taiwan
facility: Wan-Lin Pan
Study officials:
affiliation: National Taipei University of Nursing and Health Sciences
name: Wan-Lin Pan, PHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02617030: Developing a Program for Transition to Adult Care for Youth With Chronic Conditions : a Mixed Method Study
Official title: Developing a Program for Transition to Adult Care for Youth With Chronic Conditions : a Mixed Method Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Transition Care
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2015-11-30
Enrollment: 390
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Youth with chronic diseases after transfer to adult care

Brief summary: Investigation in 3 steps the transition of young people with chronic diseases. FIRST STEP: qualitative survey. Interviews with carers, young people and parents. Chronic Diseases studied: epilepsy, HIV, sickle cell disease, obesity. SECOND STEP: Delphi consensus survey. Vote on internet : carers, patients' associations, young people and family. Chronic Diseases studied: all. THIRD STEP: validation survey. Vote on internet : young people. Chronic Diseases studied: all.


Eligibility criteria: Inclusion Criteria:

* Youth with chronic diseases after transfer to adult care
* Parents or guardians of these youth.
* Professionals caregivers from pediatric services and adult services involved in transition

Exclusion Criteria:

-

Primary outcomes:
measure: Agreement rate for each component of the transition program defined
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Robert Debré Hospital
Study officials:
affiliation: Assistance Publique - Hôpitaux de Paris
name: Serge Gottot, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Le Roux E, Mellerio H, Guilmin-Crepon S, Gottot S, Jacquin P, Boulkedid R, Alberti C. Methodology used in comparative studies assessing programmes of transition from paediatrics to adult care programmes: a systematic review. BMJ Open. 2017 Jan 27;7(1):e012338. doi: 10.1136/bmjopen-2016-012338.
citation: Le Roux E, Gottot S, Aupiais C, Girard T, Teixeira M, Alberti C. Professional's Perspectives on Care Management of Young People with Perinatally Acquired HIV during Transition: A Qualitative Study in Adult Care Setting. PLoS One. 2017 Jan 23;12(1):e0169782. doi: 10.1371/journal.pone.0169782. eCollection 2017.
citation: Le Roux E, Mellerio H, Jacquin P, Bourmaud A, Guilmin-Crepon S, Faye A, Matheron S, Boulkedid R, Alberti C. Practical generic guidelines for paediatric-to-adult transition for adolescents with chronic disease. Eur J Public Health. 2019 Jun 1;29(3):442-448. doi: 10.1093/eurpub/cky258.
Clinical trial NCT01630330: Contact Force Sensing Use in Atrial Fibrillation Ablation
Official title: The Role of Contact Force Sensing in Electrical Pulmonary Vein Isolation When Conducting Atrial Fibrillation Ablation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Atrial Fibrillation
Lead sponsor: Royal Brompton & Harefield NHS Foundation Trust
Sponsor class: OTHER
First posted: 2012-06-28
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: There are multiple important factors which need to be monitored when conducting ablation for atrial fibrillation. The contact between the catheter tip and the inside of the heart wall is now measurable and may improve the effectiveness of catheter ablation for atrial fibrillation patients.

Detailed description: This study compares patients who have this procedure where this contact information is known (unblinded) versus those where the contact information is not known (blinded). The outcome is the rate of acute reconnection at 1 hour after achieving pulmonary vein isolation.

Eligibility criteria: Inclusion Criteria:

* Patients with symptomatic AF

Exclusion Criteria:

* Recent CVA
* Contraindication to warfarin therapy

Primary outcomes:
measure: Rate of Acute Pulmonary Vein Reconnection
timeFrame: 1 hour post procedure
Secondary outcomes:
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: Royal Brompton & Harefield Hospital NHS Foundation Trust
Study officials:
References:
Clinical trial NCT06777030: Role of Exosomes in Pancreatic Cancer Progression
Official title: Role of Exosomes in Pancreatic Cancer Progression
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Pancreatic Cancer
Lead sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sponsor class: OTHER
First posted: 2025-01-15
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study involves the enrollment of patients hospitalized for diagnostic-therapeutic evaluation of pancreatic neoformation. In particular, patients will be included for whom biopsy sampling of the pancreatic lesion by means of an ultrasound-guided needle biopsy is planned during hospitalization.

Brief summary: The present pilot study is set up with the objective of identifying circulating markers in the biological fluids (blood and urine) of subjects with pancreatic carcinoma and their association with disease stage, to evaluate their potential use as predictive and diagnostic markers for this tumor of difficult early diagnosis and often inauspicious prognosis.

Detailed description: The study is cross-sectional, single-center, spontaneous, in human tissues. It is a pilot study to gather evidence on the content of extracellular vesicles/exosomes in patients with pancreatic cancer.

The study will be performed on tumor tissue, blood and urine samples. Tissue will be obtained by needle biopsy (fine needle biopsy - FNB) during echoendoscopic examination.

The study aims to characterize the content of extracellular vesicles/exosomes in the biological fluids of subjects with pancreatic cancer with the goal of identifying new markers for this disease. To this end, the following will be carried out:

* an ex vivo and in vitro characterization study of the secretion of these extracellular vesicles/exosomes with analysis of their contents in terms of proteins and nucleic acids;
* a study of the mechanisms of epithelial-mesenchymal transition (EMT), invasion and aggressiveness to highlight a possible association between the secretion of these vesicles and the oncological stage of pancreatic carcinoma;

Eligibility criteria: Inclusion criteria:

* People with pancreatic cancer
* 18 years old
* Obtaining informed consent.

Exclusion criteria:

* Patients who do not need or cannot perform endoscopy with biopsy sampling;
* patients with a previous or active neoplastic pathology, different from pancreatic neoplasia.

Primary outcomes:
measure: Characterise the extracellular vesicle/exosome content of patients with pancreatic carcinoma.
timeFrame: At baseline, visit V1.
Secondary outcomes:
Other outcomes:
Locations:
city: Bologna
country: Italy
facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Study officials:
affiliation: IRCCS Azienda Ospedaliero-Universitaria di Bologna
name: Leonardo Henry Umberto Eusebi, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05500430: Evaluation of Air Abrasion Surface Pretreatment in the Repairing Capacity of Defective Composite Restoration
Official title: Clinical Evaluation of Bioactive Injectable Hybrid Resin Composite Restoration With or Without Air Abrasion Surface Pretreatment in the Repairing Capacity of Defective Composite Restoration, A Randomized Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Repair
Keywords: repair
defective restoration
sandblasting
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2022-08-15
Enrollment: 39
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is conducted to compare the efficacy of surface pretreatment using air abrasion sandblasting aluminum oxide particles (Al2O3) versus not pretreatment in the repair capacity of defective composite restoration indicated for repair.

Detailed description: First the rationale for the repair, rather than the replacement of defective direct composite restorations proved a less invasive procedure with decreased tooth loss avoiding weakening and overtreatment of tooth. Less traumatic or stressful than replacement for patients with good acceptance; Increased longevity of the restoration; Reduction of potentially harmful effects on the dental pulp and Less risk of iatrogenic damage to adjacent teeth.

Secondary using surface treatment strategies aim to prepare a clean surface with high surface energy to provide better wettability with adequate surface roughness and surface area by removing the superficial layer of the aged composite which lead to increase integrity between old and new resin restoration.

Eligibility criteria: Inclusion Criteria:

* Co-operative patients approving to participate in the trial.
* patient with occlusal defects class I or class II composite resin restorations indicated for repair.

Exclusion Criteria:

* Allergic history concerning methacrylate.
* Rampant caries.

  * Disabilities patient
  * Pregnancy
  * Heavy smoking.
  * Xerostomia.
  * Lack of compliance.
  * Evidence of parafunctional habits.
  * Temporomandibular joint disorders.

Primary outcomes:
measure: Change in the clinical performance
timeFrame: Change from the baseline at 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Dentistry
Study officials:
affiliation: heba.hamza@dentistry.cu.edu.eg
name: heba hamza, Professor
role: STUDY_DIRECTOR
References:
Clinical trial NCT06848530: Neurophysiology of the Basal Ganglia, Thalamus, and Cerebellum in Patients With Movement Disorders
Official title: Neurophysiology of the Basal Ganglia, Thalamus, and Cerebellum in Patients With Movement Disorders
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Movement Disorders
Lead sponsor: University of Pennsylvania
Sponsor class: OTHER
First posted: 2025-02-27
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The research study is being conducted to better understand parts of the human brain called the cortex, basal ganglia, thalamus, and cerebellum in patients with movement disorders (such as Parkinson's disease, essential tremor, dystonia, or ataxia). These brain structures are involved in movement disorders. This study attempts to better understand the brain electrical activity associated with these disorders, both in patients with and without deep brain stimulation (DBS). Recordings are made from the scalp with a noninvasive electrode and/or through the DBS stimulator if the participant has a stimulator model that is able to sense brain activity. These recordings are analyzed along with measures of movement disorder symptoms to identify brain signal signatures of symptoms.


Eligibility criteria: Inclusion Criteria:

* Patients 18 years of age and above
* Any patient who has been diagnosed by a movement disorders neurologist with one of the following movement disorders:
* Parkinson's disease
* Dystonia
* Tremor, including essential tremor
* Cerebellar ataxia
* Other hyperkinetic movement disorders, such as chorea and tics

Exclusion Criteria:

- Patients with dementia

Primary outcomes:
measure: Neural signal biomarkers
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Pennsylvania Hospital
state: Pennsylvania
Study officials:
References:
Clinical trial NCT06188130: The Effects of rTMS and tDCS Combined With Robotic Rehabilitation In Patients With Spinal Cord Injury
Official title: The Effect of rTMS and tDCS Treatments Combined With Robotic Rehabilitation on Gait and Motor Recovery in Partial Chronic Spinal Cord Injury
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Chronic Spinal Cord Disorder
Lead sponsor: Ankara City Hospital Bilkent
Sponsor class: OTHER
First posted: 2024-01-03
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the effect of rTMS and tDCS combined with robotic therapy on motor functional recovery and gait parameters

Detailed description: After being informed about study and potential risks, all patient giving written informed consent will undergo screening period determine eligibility for study entry. The patients who meet the eligibility requirements will be randomized into four groups in a 1:1 ratio to active rTMS, sham rTMS, active tDCS and sham tDCS.

Eligibility criteria: Inclusion Criteria:

* Having traumatic SCI
* Between 6 months and 2 years after SCI
* 18-65 years old
* Signing an informed consent form showing his/her consent to participate in the study.
* Motor incomplete cervical or thoracic SCI
* Spasticity in the lower extremity ≤2 according to the Modified Ashworth Scale

Exclusion Criteria:

* History of epilepsy
* A cardiac pacemaker
* Pregnancy
* Neurological diseases other than SCI
* Metallic implant in brain or scalp (including cochlear implant)
* Previous brain surgery
* Orthopedic disease that prevents lower extremity movements
* Diagnosis of malignancy
* Receiving robotic /TMS/tDCS treatments in the last 6 months

Primary outcomes:
measure: Lower extremity motor scores according to ASIA examination
timeFrame: initial, 3th week 9th week changes
measure: Walking Index for SCI - II (WISCI-II)
timeFrame: initial, 3th week 9th week changes
measure: 10 meter walking test
timeFrame: initial, 3th week 9th week changes
Secondary outcomes:
measure: Modified Ashworth Scale
timeFrame: initial, 3th week 9th week changes
measure: Visual Analogue Scale
timeFrame: initial, 3th week 9th week changes
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara Bilkent City Hospital Pyhsical Treatment and Rehabilitation Hospital
Study officials:
affiliation: Ankara City Hospital Bilkent
name: Emre Adıgüzel
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03608930: Comparison of Using Regular or Rotary Polypectomy Snare for the Resection of Colorectal Polyps
Official title: Comparison of Hot Snare Polypectomy Using Regular or Rotary Polypectomy Snare for the Resection of Colorectal Polyps: a Prospective Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Polypectomy Snare
Lead sponsor: Ningbo No. 1 Hospital
Sponsor class: OTHER
First posted: 2018-08-01
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This clinical trial is being conducted to assess whether the rotary polypectomy snare could decrease the time to removal of colorectal polyps


Eligibility criteria: Inclusion Criteria:

18-85 year;

Patients with colorectal polyps ;

informed consent;

Exclusion Criteria:

patients taking antiplatelet or anticoagulant therapy during the past 1 week of the procedure;

known coagulopathy;

history of inﬂammatory bowel diseases;

Hemodynamically unstable;

pregnancy

Primary outcomes:
measure: the average time of each polyp removing
timeFrame: 1day
Secondary outcomes:
measure: Postpolypectomy bleeding
timeFrame: 2 weeks
Other outcomes:
measure: The procedure time
timeFrame: 1day
Locations:
city: Ningbo
country: China
facility: Ningbo NO.1 hospital
state: Zhejiang
Study officials:
affiliation: Department of Gastroenterology, Ningbo No. 1 Hospital, Ningbo, China
name: Lei XU, PHD
role: PRINCIPAL_INVESTIGATOR
References: