Clinical trial NCT01887457: Individualisation of Voriconazole Antifungal Therapy Antifungal Therapy
Official title: PIVOTAL: Pharmacological Individualisation of VOriconazole Therapy for AntifungaL Treatment
Study type: INTERVENTIONAL
Overall status: SUSPENDED
Phase: PHASE2
Conditions: Immunocompromised Patient
Aspergillosis
Fusarium
Keywords: voriconazole
VFEND
individualised
personalised
Lead sponsor: The Christie NHS Foundation Trust
Sponsor class: OTHER
Collaborators: name: The Christie NHS Foundation Trust
First posted: 2013-06-26
Enrollment: 33
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a trial to determine whether giving a patient a tailored dose of voriconazole is safe and effective.

Detailed description: Invasive fungal infections are a major cause of morbidity and mortality in patients with haematological malignancy and haematopoietic stem cell transplantation.

Voriconazole is routinely used as a first-line agent for the treatment of invasive aspergillosis, invasive fusariosis and scedosporiosis. Voriconazole has extreme pharmacokinetic variability. Adult patients with a trough concentration of \< 1 mg/L have a lower probability of clinical response whereas patients with trough concentrations \> 6 mg/L a higher probability of toxicity.

Therapeutic drug monitoring for dose adjustment is advocated but there are no algorithms that enable voriconazole dosage to be reliably adjusted to achieve desired trough concentrations in a timely and optimally precise manner.

Novel ways to deliver optimised antifungal therapy are urgently required and this trial will evaluate whether giving a patients a tailored dose of voriconazole is safe and effective.

Plasma concentrations will be taken in real time and inputted in dose software that will calculate an optimum dose for the required trough concentration of 1-3 mg/L.

The software has been developed using data from phase I and III trials of voriconazole.

Eligibility criteria: Inclusion Criteria:

* Any adult ≥18 years old
* Patients where a new course of voriconazole is indicated for suspected or confirmed invasive aspergillosis or other serious fungal infections that is deemed by the treating physician to be susceptible to voriconazole
* Patients must have venous access to permit the administration of voriconazole and enable the procurement of multiple plasma samples to measure voriconazole concentrations.
* Estimated creatinine clearance ≥ 50 mL/min
* Able to give written informed consent
* Considered fit to receive the trial treatment
* Able to remain in the hospital for at least 5 days or until they complete their trial treatment
* Female patients must satisfy the investigator that they are not pregnant, or are not of childbearing potential, or are using adequate contraception
* Men must also use adequate contraception

Exclusion Criteria:

* Patients with an estimated creatinine clearance \< 50 mL/minute (this precludes the use of intravenous voriconazole)
* Patients receiving any form of renal replacement therapy i.e. haemodialysis or haemofiltration
* Patients with hepatic insufficiency
* Female patients that are pregnant, breast feeding or planning pregnancy during the study
* Past history of intolerance to voriconazole
* Age \<18
* Evidence of a clinically relevant fungal isolate that is resistant to voriconazole
* QT prolongation on ECG
* Use of other medications that contraindicate the use of voriconazole
* Patients receiving any other medications that are contraindicated with the use of voriconazole i.e. terfenadine, long acting barbiturates, ergot alkaloids, etc. (Refer to SMPC). Only patients on rifampicin, rifabutin, phenytoin, and carbamazepine would have voriconazole precluded. Voriconazole influences with the pharmacokinetics of many additional agents- (see SMPC)- most importantly anti-rejection compounds- cyclosporine, tacrolimus\]
* Uncontrolled cardiac, respiratory or other disease or any serious medical or psychiatric disorder that would preclude trial therapy or informed consent.
* Hypersensitivity to Voriconazole, its excipients or other triazoles

Primary outcomes:
measure: Dose adjustment success
timeFrame: Day 5 of treatment
Secondary outcomes:
measure: Mortality of patients
timeFrame: 35 Day after starting treatment
measure: Toxicity
timeFrame: Day 5 of treatment and 35 day follow-up
Other outcomes:
Locations:
city: Manchester
country: United Kingdom
facility: The Christie NHS Foundation Trust
Study officials:
affiliation: University of Liverpool
name: William Hope
role: STUDY_CHAIR
References: