Clinical trial NCT02850367: Effect of NO Precursors on Physiological Responses to Exercise
Official title: The Effect of NO Precursors on Physiological Responses to Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Physiology
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2016-08-01
Enrollment: 63
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: NO is an ubiquitous molecule contributing to many physiological functions such as vasodilation, immune and oxidative stress responses. NO production can be supplemented either by providing substrate to the NO-synthase (L-Arginine and L-Citruline) or by providing nitrate which can lead to NO. In the present project the investigators evaluate the effect of various acute and chronic oral NO precursors supplementation on exercise performance and responses in healthy young and older subjects.


Eligibility criteria: Inclusion Criteria:

* Sedentary subjects
* No cardiovascular, respiratory, metabolic and neurological disorders

Exclusion Criteria:

* Body mass index \> 28 kg.m-2
* Smoker
* Alcool intake \> 10g/day
* Psychiatric diseases
* Subjects under treatment able to interfere with their cardiovascular, metabolic and neurological status

Primary outcomes:
measure: Neuromuscular evaluations
timeFrame: 3 half days
measure: Evaluation of post-ischemic vascular reactivity
timeFrame: 3 half days
Secondary outcomes:
Other outcomes:
Locations:
city: Grenoble
country: France
facility: Grenoble University Hospital
state: Rhone Alpes
Study officials:
affiliation: University Hospital, Grenoble
name: Stéphane Doutreleau, PhD
role: PRINCIPAL_INVESTIGATOR
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