Clinical trial NCT02285257: Epidemiology of Sepsis at Yuetan Subdistrict in Beijing
Official title: Epidemiology of Sepsis at Yuetan Subdistrict in Beijing
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Sepsis
Keywords: Sepsis, Severe sepsis, septic shock, epidemiology, outcome
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2014-11-06
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Questionnaires were used to collect the characteristic information of people living in Yuetan subdistrict in Beijing for more than 1 years people who had been hospitalized because of any reasons between July 2012 and June 2014 were selected.Patients were included in the study cohort when having, in association with a documented or strongly suspected infection and fullfil the diagnostic criteria of sepsis according to the "Surviving Sepsis Campaign:International guidelines for management of severe sepsis and septic shock:2012".

Brief summary: The purpose of this study is to determine the epidemiology and outcome of sepsis at Yuetan subdistrict in Beijing in mainland China).

Detailed description: 1. Questionnaires were used to collect the characteristic information of people living in Yuetan subdistrict in Beijing and select people who had been hospitalized because of any reasons between July 2012 and June 2014.
2. Data were collected on all patients admitted into different hospitals during the study period. The following information was recorded:demographic characteristics and admission category (whether medical, scheduled surgery, nonoperative trauma, or unscheduled surgery), presence of preexisting organ insufficiency,using definitions included in the Acute Physiology and Chronic Health Evaluation (APACHE) II score11; co- morbidities and the estimated prognosis of any preexisting underlying disease, following the classification of McCabe and Jackson.
3. Patients were included in the study cohort when having, in association with a documented or strongly suspected infection and fullfil the diagnostic criteria of sepsis according to the "Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock:2012".

Eligibility criteria: Inclusion Criteria:

* Age≥18 years;
* Having lived in Yuetan Subdistirct for at least 1 year
* Having, in association with a documented or strongly suspected infection and fullfil the diagnostic criteria of sepsis according to the "Surviving Sepsis Campaign:International guidelines for management of severe sepsis and septic shock:2012"

Exclusion Criteria:

* Age\<18 years
* Lived in Yuetan Subdistrict less than 1 year

Primary outcomes:
measure: incidence of sepsis of people living in Yuetan subdistrict in Beijing
timeFrame: 2012-7-1~2014-6-30, up to 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: MICU of Peking Union Medical College Hospital
state: Beijing
Study officials:
affiliation: Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences
name: Bin Du, professor
role: STUDY_DIRECTOR
References:
citation: Tian HC, Zhou JF, Weng L, Hu XY, Peng JM, Wang CY, Jiang W, Du XP, Xi XM, An YZ, Duan ML, Du B; for China Critical Care Clinical Trials Group (CCCCTG). Epidemiology of Sepsis-3 in a sub-district of Beijing: secondary analysis of a population-based database. Chin Med J (Engl). 2019 Sep 5;132(17):2039-2045. doi: 10.1097/CM9.0000000000000392.