Clinical trial NCT06924294: Pattern and Short Term Outcomes of Renal Affection in Patients With Liver Cirrhosis in Al-Rajhi Liver Hospital
Official title: Pattern and Short Term Outcomes of Renal Affection in Patients With Liver Cirrhosis in Al-Rajhi Liver Hospital
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Liver Cirrhosis
Keywords: renal affection in patients with liver cirrhosis
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-04-11
Enrollment: 290
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with liver cirrhosis admitted to the department .

Brief summary: * To characterize the pattern and the prevalence of renal affection among liver cirrhosis patients.
* To evaluate the short-term outcomes of those patients.

Detailed description: Liver cirrhosis is a chronic liver disease characterized by significant scarring and dysfunction. One of its common complications is renal affection , which can significantly impact patient outcomes .

Aetiology of AKI can be categorized into three main types. These are prerenal (results from decreased renal perfusion), intrinsic renal (acute tubular necrosis), and postrenal AKI. In patients on admission, acute tubular necrosis is a common type of intrinsic AKI .

The development of portal hypertension in patients with liver cirrhosis leading to a reduction in systemic vascular resistance as a result of primary arterial vasodilation in the splanchnic circulation is the primary cause of AKI in cirrhotics. This mechanism primarily leads to hepatorenal syndrome. In addition, the underlying causes of liver cirrhosis can be the cause of intrinsic renal disease .

Early identification and management of AKI may improve outcomes. AKI in patients with liver cirrhosis in Egypt and their impact on inpatient mortality are largely unknown. This study was aimed at determining the prevalence, precipitating factors, predictors, and in-hospital mortality of AKI in patients with liver cirrhosis admitted at Al-Rajhi liver hospital at Egypt .

Eligibility criteria: Inclusion Criteria:

* Patients with liver cirrhosis admitted to the department .

Exclusion Criteria:

1. Patients with known preexisting chronic kidney disease according to KDIGO and EASL 2018 definitions ( defined as functional GFR \<60 ml/min per 1.73 m 2 for ≥3 months or structural kidney damage for ≥3 months ).
2. Patient refusal to give informed consent ( or his first degree relatives in case of disturbed conscious level).

Primary outcomes:
measure: In-hospital mortality
timeFrame: Through the study completion , average 6 months
measure: Phenotypes of acute kidney injury across geographic areas
timeFrame: Baseline ( at admission ), then through the study completion, average 6 months
Secondary outcomes:
measure: 28-day mortality
timeFrame: 28 days
measure: Resolution of AKI
timeFrame: Hospital stay (up to 90 days)
measure: Development of CKD
timeFrame: 90 days
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Al-Raghi liver hospital
state: Assuit
Study officials:
affiliation: Assiut University
name: Mohamed Omar Abd El-Malek, professor
role: STUDY_DIRECTOR
References:
citation: Choi YJ, Kim JH, Koo JK, Lee CI, Lee JY, Yang JH, Ko SY, Choe WH, Kwon SY, Lee CH. Prevalence of renal dysfunction in patients with cirrhosis according to ADQI-IAC working party proposal. Clin Mol Hepatol. 2014 Jun;20(2):185-91. doi: 10.3350/cmh.2014.20.2.185. Epub 2014 Jun 30.
citation: Duah A, Nkrumah KN. Prevalence and predictors for spontaneous bacterial peritonitis in cirrhotic patients with ascites admitted at medical block in Korle-Bu Teaching Hospital, Ghana. Pan Afr Med J. 2019 May 16;33:35. doi: 10.11604/pamj.2019.33.35.18029. eCollection 2019.