Clinical trial NCT01832467: Cetuximab Rechallenge Study
Official title: A Pilot Case-control Study of Second or Third Line Treatment With Cetuximab-containing Chemotherapy in Patients With Metastatic Colorectal Cancer Who Were Previously Treated With Cetuximab-based Chemotherapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Metastatic Colorectal Cancer
Keywords: cetuximab-based chemotherapy
previously treated
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2013-04-16
Enrollment: 17
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To determine the objective overall response of re-treatment with cetuximab-based chemotherapy in patients upon disease progression while under observation, who had previously responded to first-line or second-line treatment with cetuximab-based chemotherapy for metastatic colorectal cancer (mCRC), but had stopped treatment for reasons other than disease progression.


Eligibility criteria: Inclusion Criteria:

* Age 18 years or older.
* Able to give written informed consent.
* Histologically confirmed colorectal adenocarcinoma: must be either metastatic disease or unresectable recurrent disease.
* KRAS mutation status of the primary or metastastic CRC tumor must be wild-type.
* ECOG performance status of 0-1 at study entry.
* Must have measurable disease by RECIST (ver 1.1) criteria.
* Have progressive disease based on all of the following criteria (from a-d):

  (a) Previously received cetuximab-based chemotherapy as first- or second-line treatment for metastatic or recurrent disease with, any one of the following drug combinations: (i) Cetuximab, fluoropyrimidines and oxaliplatin; or, (ii) Cetuximab, fluoropyrimidines and irinotecan; or (iii) Cetuximab and irinotecan. (b) Must have achieved at least stable disease, partial or complete response to treatment stated in '(a)' above.

  (c) Experienced disease progression after more than 60 days from the last date of administration of the treatment stated in '(a)' above.

  (d) 'Disease progression' can be defined as radiological or clinical progression.
* Adequate hematologic, renal, hepatic function as defined by: absolute neutrophil count \>= 1.5 x 109/L, hemoglobin \>= 9 g/L, platelets \>= 100 x 109/L, calculated creatinine clearance \>=55 ml/min, total bilirubin \<= 2 x the upper limit of normal (ULN), alanine aminotransferase (ALT) \<2.5 upper limit of normal or \<= 5 x ULN in the presence of liver metastases.
* Must have recovered to grade 0-1 in severity, any toxicity related to previous cetuximab.

Exclusion Criteria:

* Disease progression during first-line or second-line treatment with cetuximab and chemotherapy in combination.
* Patients who had prior cetuximab in BOTH first and second-line setting.
* Previous use of bevacizumab.
* Prior grade 3 to 4 hypersensitivity reaction to cetuximab.
* Clinically significant and poorly controlled medical illnesses within the last 6 months which may be exacerbated by study treatment.
* Estimated life expectancy of less than 3 months.
* Radiotherapy, surgery (excluding prior diagnostic biopsy) or any investigational drug in the 30 days before enrollment. Radiotherapy for pain relief is allowed as long as not targeted at an index or non-index lesion, e.g., bone metastases.
* Known brain and/or leptomeningeal metastases.
* Severe or uncontrolled cardiovascular disease (congestive heart failure NYHA III or IV, unstable angina pectoris, history of myocardial infarction within the last twelve months, significant arrhythmias
* Pregnancy or lactation
* Previous malignancy other than colorectal cancer in the last 5 years except basal cell cancer of the skin or preinvasive cancer of the cervix. The non-CRC malignancy must be in known complete remission for at least 5 years prior to enrollment.
* The presence of KRAS mutation in any of the CRC tumor tissue(s) - for example, patients with synchronous primary CRCs with different KRAS mutation status.
* Participants with reproductive potential who are unwilling to perform effective contraception.

Primary outcomes:
measure: overall response of re-treatment with cetuximab-based chemotherapy
timeFrame: 2 years
Secondary outcomes:
measure: Adverst event and toxicity during treatment period
timeFrame: 2 years
measure: disease control rate
timeFrame: 2 years
measure: progression-free survival
timeFrame: 2 years
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: Department of Clinical Oncology, Prince of Wales Hospital
Study officials:
affiliation: Chinese University of Hong Kong
name: Brigette MA, MD, FRCP
role: PRINCIPAL_INVESTIGATOR
References: