Clinical trial NCT06663267: Acute Effects of Meteorological Factors and Air Pollution on Cardiovascular Health
Official title: Acute Effects of Meteorological Factors and Air Pollution on Cardiovascular Health
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cardiovascular System
Health
Keywords: Cardiovascular System
Air Pollution Exposure
Acute effect
Weather
Lead sponsor: The Affiliated Hospital of Hangzhou Normal University
Sponsor class: OTHER
First posted: 2024-10-29
Enrollment: 350000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 1. Target population: adults who have been recorded at least three times in the physical examination database will be included in this study. This requirement aims to ensure that the participants\&amp;#39; health status can be fully evaluated historically, and then to study the changes of various health indicators over time.
2. Sample source and recruitment: Participants will be selected from the routine physical examination database of several hospital physical examination centers in Zhejiang, Henan, Anhui, Guizhou and other provinces.

Brief summary: The goal of this observational study is to analyze the acute effects of meteorological factors and air pollution on cardiovascular system. The main question it aims to answer is:

1. How do meteorological factors and air pollution affect cardiovascular system?
2. What is the interaction between meteorological factors and air pollution on cardiovascular system?

Participants will:

1. Provide their health data obtained in physical examination, including but not limited to blood pressure, blood routine, urine routine and B-ultrasound.
2. agree that the research team will use their personal identification number, gender, age, education level and other information for statistical analysis of the data.

Detailed description: The collected data include: ID number (or unique identification code similar to ID number), physical examination date, work unit, occupation, gender, age, systolic blood pressure, diastolic blood pressure, height, weight, blood routine, urine routine and blood biochemical examination results,Color Doppler (or B-ultrasound) examination results (thyroid color Doppler, abdominal color Doppler, urinary color Doppler, cardiac color Doppler, cervical vascular color Doppler, etc.), electrocardiogram, cardiac CTA, carbon 13 breath test, and written diagnosis results of liver fibrosis.

Eligibility criteria: Inclusion Criteria:

·Relevant records in the physical examination database shall be ≥3 times

·≥18 years old

Exclusion Criteria:

* Relevant records in the physical examination database shall be ≥３times
* Serious heart and lung diseases
* Malignant tumors
* Serious mental illness in the past

Primary outcomes:
measure: Troponin
timeFrame: The troponin data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.
measure: Blood pressure
timeFrame: The blood pressure data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.
Secondary outcomes:
measure: Left ventricular ejection fraction（LVEF）
timeFrame: The left ventricular ejection fraction（LVEF）data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.
measure: White cell count
timeFrame: The white cell count data were tested at baseline 3 months before exposure to meteorological factors or air pollution, and followed up for 1 year and 2 years after exposure.
measure: Controlled Attenuation Parameter（CAP）
timeFrame: The Controlled Attenuation Parameter（CAP）data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.
measure: ST segment of electrocardiogram
timeFrame: The ST segment of electrocardiogram were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.
measure: Degree of coronary artery stenosis
timeFrame: The degree of coronary artery stenosis data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.
measure: Weight
timeFrame: The weight data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.
measure: Height
timeFrame: The height data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.
measure: Urinary glucose
timeFrame: The urinary glucose data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.
Other outcomes:
Locations:
city: Hanzhou
country: China
facility: MingWei Wang
state: Zhejiang
Study officials:
References:
citation: Clement DL, De Buyzere ML, De Bacquer DA, de Leeuw PW, Duprez DA, Fagard RH, Gheeraert PJ, Missault LH, Braun JJ, Six RO, Van Der Niepen P, O'Brien E; Office versus Ambulatory Pressure Study Investigators. Prognostic value of ambulatory blood-pressure recordings in patients with treated hypertension. N Engl J Med. 2003 Jun 12;348(24):2407-15. doi: 10.1056/NEJMoa022273.
citation: McCarron P, Smith GD, Okasha M, McEwen J. Blood pressure in young adulthood and mortality from cardiovascular disease. Lancet. 2000 Apr 22;355(9213):1430-1. doi: 10.1016/S0140-6736(00)02146-2.
citation: Tandon S, Grande AJ, Karamanos A, Cruickshank JK, Roever L, Mudway IS, Kelly FJ, Ayis S, Harding S. Association of Ambient Air Pollution with Blood Pressure in Adolescence: A Systematic-review and Meta-analysis. Curr Probl Cardiol. 2023 Feb;48(2):101460. doi: 10.1016/j.cpcardiol.2022.101460. Epub 2022 Oct 18.