Clinical trial NCT06739148: The Enhancement Effect of Low-Level Laser Therapy for Muscle Training with Combined NMES and BFR
Official title: The Enhancement Effect of Low-Level Laser Therapy for Muscle Training with Combined Neuromuscular Electrical Stimulation and Blood Flow Restriction
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Blood Flow Restriction Therapy
Neuromuscular Electrical Stimulation (NMES)
Laser Therapy, Low-Level
Muscle Strength
Keywords: Muscle strength
Training
Low-level laser Therapy
Blood flow restriction
Neuromuscular electrical stimulation
Lead sponsor: National Cheng-Kung University Hospital
Sponsor class: OTHER
First posted: 2024-12-18
Enrollment: 44
Sex: ALL
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Blood flow restriction training (BFR) with neuromuscular stimulation (NMES) is employed for individuals with limited mobility and joint issues. However, this approach is highly susceptible to muscle fatigue, despite its potential beneficial effects on muscle strength. Recently, there has been growing interest in using low-level laser therapy (LLLT) to address muscle fatigue. LLLT, known for improving microcirculation and mitochondrial function, shows promise in alleviating enhanced muscle fatigue associated with combined BFR and NMES training. Despite these positive effects, there is limited knowledge about the short-term training impact of combined BFR and NMES with LLLT preconditioning. This project aims to investigate whether the photobiomodulation effects of LLLT could further enhance the training benefits of combined BFR and NMES. The study will employ an integrated analysis of decomposition surface EMG, EEG, and mechanomyogram to explore the behavior and neuromuscular mechanisms underlying the training benefits. If additional benefits are identified, LLLT pre-conditioning is recommended to enhance the use of combined BFR and NMES.


Eligibility criteria: Inclusion Criteria:

1. Healthy adults aged 20-40, without a diagnosis of cardiovascular or neuromusculoskeletal diseases.
2. Normal vision range after visual correction.

Exclusion Criteria:

1. Exclude students who have a teacher-student relationship with the principal investigator to ensure the participants\&#39; autonomy.
2. History of brain injury, stroke, spinal cord injury, or other neuromuscular-related conditions.
3. Contraindications for laser therapy: pregnancy, malignant tumor tissues, bleeding areas, and photosensitive skin regions.
4. Presence of any contraindications for blood flow restriction training, such as a history of injury or strain in the non-dominant arm\&#39;s biceps, deep vein thrombosis or venous occlusion in the non-dominant arm, acute unstable fractures in the non-dominant arm, acute regional infections in the non-dominant arm, severe peripheral arterial occlusive disease in the non-dominant arm, complete lymphatic obstruction in the non-dominant arm, and edema due to acute pulmonary edema or congestive heart failure in the non-dominant arm.

Primary outcomes:
measure: Myoton
timeFrame: before training, 1week of training, 2 weeks of training, at the end of 3 weeks training
measure: Mechanomyogram
timeFrame: before training, 1week of training, 2 weeks of training, at the end of 3 weeks training
measure: Multi-electrode surface EMG
timeFrame: before training, at the end of 3 weeks training
measure: Dynamometer System
timeFrame: before training, 1week of training, 2 weeks of training, at the end of 3 weeks training
Secondary outcomes:
Other outcomes:
Locations:
city: Tainan
country: Taiwan
facility: National Chen Kong University Hospital, Tainan
Study officials:
affiliation: NCKU, Institute of Allied Health Sciences
name: Ing-Shiou Hwang, PhD
role: STUDY_CHAIR
References: