Clinical trial NCT05808426: Benefits of Online Mahjong by Older Adults
Official title: Randomized Trial of Online Mahjong Intervention to Promote Cognitive Function and Health Status in Community-dwelling Middle Aged and Older Adults.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aged
Keywords: online Mahjong
physical activity
cognitive function
quality of life in older adults
Lead sponsor: National Yang Ming Chiao Tung University
Sponsor class: OTHER
First posted: 2023-04-11
Enrollment: 60
Sex: ALL
Minimum age (years): 55
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This study is a single-blind, parallel-group randomized controlled trial. Eligible participants were allocated randomly 1:1, without stratification, to either the intervention or the control group, according to a computer-generated random number sequence.
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study aims to examine the clinical efficacy of online Mahjong in improving physical health, cognitive performance, happiness, laboratory biomarkers, and structural brain imaging (magnetic resonance imaging, MRI) by a randomized controlled trial design, and hopefully to expand the scope of healthy aging intervention activities with strong scientific evidence.

Detailed description: Psychomotor function among older adult's decline was associated with reducing people interaction during pandemic has been reported. The research focused on examining the benefit and efficacy of digital based Mahjong games with 6-month intervention is very limited or none. A random control design was conducted with comparing intervention group and with control group, followed the CONSORT guidelines. Six months program was intervened to ensure the impact of the intervention. Primary outcome is brain imagery changes between groups, which showed changes in temporal fusiform cortex but not in resting-state fMRI. The total score of MoCA, delayed recall was increase from baseline to after intervention in experimental group. Overall cognitive function and visuospatial/executive, in experimental group improved more than control group. Improving self-rating daily health status as associated with achievement rate of Mahjong game. Increasing level of resilience was associated with demoralization level, subtraction of cognitive function, and 5th month walking steps. In addition, affecting incased self -rate overall heath was related to demoralization. In short, online mahjong intervention has positive impact on older adults in cognitive function , resilience, demoralization and overall quality of life.

Eligibility criteria: Inclusion Criteria:

1. Age ≥ 55 years old.
2. More than 6 years of formal education.
3. Can communicate in Mandarin and Taiwanese.
4. Can accept MRI examination without claustrophobia.
5. Can understand the research process, meet the requirements of the research, and can sign the consent form and participate in the subject.

Exclusion Criteria:

1. Have engaged in any Mahjong games in the past three months.
2. Engaged in Mahjong games more than three times per year in the past three years.

Primary outcomes:
measure: Change in MRI study from baseline to 6 months in the intervention group.
timeFrame: baseline and 6 months
Secondary outcomes:
measure: Montreal Cognitive Assessment (MoCA)
timeFrame: baseline and 6 months
measure: EuroQol instrument (EQ-5D)
timeFrame: baseline and 6 months
measure: International Physical Activity Questionnaire (IPAQ)
timeFrame: baseline and 6 months
measure: Brief Resilience Scale (BRS)
timeFrame: baseline and 6 months
measure: Demoralization Scale-Mandarin Version (DS-MV)
timeFrame: baseline and 6 months
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Center for Geriatrics and Gerontology, Taipei Veterans General Hospital
Study officials:
affiliation: Center for Healthy Longevity and Aging Sciences,National Yang Ming Chiao Tung University
name: Liang-Kung Chen, PhD
role: PRINCIPAL_INVESTIGATOR
References: