Clinical trial NCT05296694: Mortality Predictors in Coronary Care in Turkey
Official title: Predictors of In-hospital MORtality in CORonary Care Patients in TURKey
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Death, Cardiac
Keywords: Coronary Care Unit
Mortality
Predictors
Lead sponsor: Afyonkarahisar Health Sciences University
Sponsor class: OTHER
First posted: 2022-03-25
Enrollment: 2560
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients (age≥18) admitted to the coronary intensive care unit for cardiovascular reasons in all centers participating in the study between the dates specified.

Brief summary: This study was undertaken to investigate and document the mortality rates and predictors in coronary care unit (CCU) patients in Turkey.

It is designed to be a multicenter, observational, cross-sectional, and descriptive study. It will be conducted in 50 centers in 12 regions of Turkey. The study does not include any interventional or treatment procedures.

At the end of the study, clinicians will have up-to-date information about predictors of mortality in CCU patients.

Detailed description: The MORCOR-TURK study will be conducted as a nationwide registry in 50 tertiary cardiology centers selected from each EuroStat NUTS region in Turkey according to their population sample weight, prioritizing the volume of hospitals in each region. All consecutive patients admitted to the coronary care units (CCU) will be prospectively admitted during a predefined period of 1 month. The study will be conducted by cardiologists in hospitals who regularly treat cardiac patients. Led by the Cardiology Department of Kutahya Evliya Celebi Research and Training Hospital, 50 centers will be included in the study.

There has not been any large-scale epidemiological study on coronary care patients in Turkey recently. Therefore, up-to-date information in this group of patients is lacking. In particular, significant reductions in mortality and morbidity are expected, thanks to improved medical and interventional facilities. In the light of current data, the investigators designed a large-scale study to document mortality rates and predictors in CCU patients.

In this study, the investigators will include consecutive patients admitted to CCU with cardiovascular indications in all participating centers. Patients will be followed and treated by experienced cardiologists and no further experimental intervention will be planned. In the first part of the study, the investigators will record in-hospital mortality rates and try to identify the best predictors. In the second part of the MORCOR-TURK trial which will have a cohort design, the investigators will follow the successfully discharged patients for 1 year. At the end of the follow-up, investigators will assess the risk factors and predictors of cardiovascular events as secondary endpoints.

Eligibility criteria: Inclusion Criteria:

* 18 years of age or older
* hospitalized with cardiovascular diseases
* individuals (or relatives for unconscious patients) who gave written informed consent

Exclusion Criteria:

* younger than 18 years of age
* rejecting to sign an informed consent
* hospitalized to CCU by other departments with noncardiac indications
* patients with active severe noncardiac chronic disease (chronic obstructive pulmonary disease, systemic diseases, and malignancy)
* no vital signs despite adequate cardiopulmonary resuscitation during hospitalization
* rejected to stay in CCU and discharged with his/her own request

Primary outcomes:
measure: All cause mortality
timeFrame: In-hospital (up to two-weeks)
Secondary outcomes:
Other outcomes:
Locations:
city: Afyonkarahisar
country: Turkey
facility: Afyonkarahisar Health Sciences University
city: Kütahya
country: Turkey
facility: Kutahya Evliya Celebi Research and Training Hospital
Study officials:
affiliation: Kutahya Health Sciences University Evliya Celebi Research and Training Hospital
name: Fatih Kahraman, MD
role: STUDY_DIRECTOR
References:
citation: Ratcliffe JA, Wilson E, Islam S, Platsman Z, Leou K, Williams G, Lucido D, Moustakakis E, Rachko M, Bergmann SR. Mortality in the coronary care unit. Coron Artery Dis. 2014 Jan;25(1):60-5. doi: 10.1097/MCA.0000000000000043.
citation: Filizcan U, Kurc E, Cetemen S, Soylu O, Aydogan H, Bayserke O, Yilmaz M, Uyarel H, Ergelen M, Orhan G, Ugurlucan M, Eren E, Yekeler I. Mortality predictors in ST-elevated myocardial infarction patients undergoing coronary artery bypass grafting. Angiology. 2011 Jan;62(1):68-73. doi: 10.1177/0003319710369103. Epub 2010 May 12.
citation: Hayiroglu MI, Keskin M, Uzun AO, Yildirim DI, Kaya A, Cinier G, Bozbeyoglu E, Yildirimturk O, Kozan O, Pehlivanoglu S. Predictors of In-Hospital Mortality in Patients With ST-Segment Elevation Myocardial Infarction Complicated With Cardiogenic Shock. Heart Lung Circ. 2019 Feb;28(2):237-244. doi: 10.1016/j.hlc.2017.10.023. Epub 2017 Nov 14.
citation: Campanile A, Castellani C, Santucci A, Annunziata R, Tutarini C, Reccia MR, Del Pinto M, Verdecchia P, Cavallini C. Predictors of in-hospital and long-term mortality in unselected patients admitted to a modern coronary care unit. J Cardiovasc Med (Hagerstown). 2019 May;20(5):327-334. doi: 10.2459/JCM.0000000000000785.