Clinical trial NCT00542048: A Trial Evaluating the Pharmacokinetics and Mode of Action of EndoTAG®-1 in Tumor Patients With Hepatic Metastases
Official title: An Open-label, Uncontrolled, Phase II Trial Evaluating the Single-dose and Steady-state Pharmacokinetics of EndoTAG®-1 and Its Effect on the Blood Supply and the Angiogenesis of Hepatic Metastases in Patients With a Carcinomatous Primary Tumor Other Than Hepatocellular (HCC), Biliary or Bile Duct Carcinoma
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Liver Cancer
Neoplasm Metastasis
Keywords: Hepatic metastases
Angiogenesis
EndoTAG-1
Pharmacokinetics
Pharmacodynamics
Metastases of the liver
Lead sponsor: MediGene
Sponsor class: INDUSTRY
First posted: 2007-10-10
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The primary objective of study CT 4003 is to assess the behavior of EndoTAG®-1 in the body (making a so-called pharmacokinetic profile). Therefore, the course of the drug in the body is examined, i.e. the amount and speed of the drug uptake as well as the distribution and the elimination of the drug is being investigated. Further objectives of the study are to assess the effect of EndoTAG®-1 on liver metastases concerning size and blood supply measured by imaging techniques (contrast-enhanced ultrasound and magnetic resonance imaging as well as duplex sonography) and to assess the effect on blood markers which are indicators for the destruction and neoplasm of blood vessels (so-called markers of angiogenesis).

Detailed description: Liver metastases are among the most frequent neoplasms of the liver and represent a quite uniform clinical entity regardless from which carcinoma they originate. The treatment is dependent on number and size of the hepatic lesions but still, none of the therapeutic options leads to satisfying results. The growth of tumors and metastases is dependent on blood vessels, which supply the tumors and metastases with nutrients. Liver metastases, independent from which original tumor they come from, are especially well supplied with blood. The aim of the treatment with the investigational medicinal product EndoTAG®-1 is to target the blood vessels, which supply the metastases, and destroy them. Consequently, the metastases themselves will be damaged.

Eligibility criteria: Inclusion Criteria:

* Unresectable hepatic metastases of a carcinomatous origin with exception of HCC, biliary or bile duct carcinoma
* At least one measurable hepatic metastases \> 20 mm in diameter (measured in MRI)
* Last application of palliative chemotherapy (drug dependent on the primary tumor) at least 7 days ago
* Gender: male and female (at least 6 individuals of each gender)
* Age \>= 18 years
* Negative pregnancy test (females of childbearing potential)
* Willingness to perform double-barrier-contraception during the study and for 6 month post study medication
* ECOG performance status 0,1 or 2
* Assumed life expectancy of \> 3 month
* Signed informed consent

Exclusion Criteria:

* History of significant liver pathology (other than metastases, e.g. cirrhosis of the liver, PSC, PBC) or liver transplantation
* Laboratory tests (hematology, chemistry) outside specific limits:
* ANC \<= 1.0 x 10\^9/L
* Platelets \<= 100 x 10\^9/L
* Hb \<= 9.0 g/dL (\<= 5.6 mmol/L)
* Total Bilirubin \> 2.0 mg/dL
* Serum Creatinine \> 1.5 mg/dL
* Renal insufficiency with a GFR \< 60 mL/min
* Currently ongoing taxane-containing palliative chemotherapy regimen or history of taxane administration within 4 weeks prior to study entry
* Pregnancy or nursing status
* Positive HIV, HBV or HCV testing
* The patient has a contraindication for MRI or CEUS according to accepted clinical guidelines
* Known hypersensitivity to any component of the EndoTAG®-1 formulation, gadolinium-based MR-contrast media or sulphur hexafluoride
* Claustrophobia or history of active or significant neurological disorder and/or psychiatric disorder that would prohibit the understanding and giving of informed consent, or would interfere in the clinical and radiological evaluation of the patient during the trial
* Concurrent treatment with other experimental drugs. Participation in another clinical trial with any investigational drug within 30 days prior to study entry

Primary outcomes:
measure: Pharmacokinetic profile
timeFrame: Last patient out
Secondary outcomes:
measure: Tumor response, Tumor perfusion, Soluble markers of angiogenesis, Pharmacodynamics, Safety
timeFrame: Last patient out
Other outcomes:
Locations:
city: Freiburg Im Breisgau
country: Germany
facility: Klinik für Internistische Onkologie in der KTB Klinik für Tumorbiologie an der Albert-Ludwigs-Universität Freiburg
state: Baden-Würtemberg
Study officials:
affiliation: Klinik für Tumorbiologie an der Albert-Ludwigs-Universität Freiburg
name: Klaus Mross, PD
role: PRINCIPAL_INVESTIGATOR
References: