Clinical trial NCT05067062: Intake Duration Effects of Blackcurrant on Cardiovascular and Metabolic Responses
Official title: Effects of Intake Duration of New Zealand Blackcurrant Extract on Physiological, Cardiovascular and Metabolic Responses at Rest and During Moderate-intensity Exercise in Healthy Males
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: no Conditions
Lead sponsor: University of Chichester
Sponsor class: OTHER
First posted: 2021-10-04
Enrollment: 15
Sex: MALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: Study will examine the metabolic, physiological and cardiovascular changes by intake of New Zealand blackcurrant extract at rest and during moderate-intensity treadmill walking in healthy males.

Detailed description: The investigators will examine effects of acute intake, intermittent intake and chronic intake of New Zealand blackcurrant extract using indirect calorimetry and hemodynamic measurements.

Eligibility criteria: Inclusion Criteria:

* Healthy
* Non-smokers
* Not taking any supplements
* No known allergy to berries or berry products

Exclusion Criteria

* Sedentary
* Known high blood pressure
* Smoking
* On medication

Primary outcomes:
measure: Changes in heart rate from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract
timeFrame: baseline, acute, one week and two weeks
measure: Changes in stroke volume from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract
timeFrame: baseline, acute, one week and two weeks
measure: Changes in cardiac output from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract
timeFrame: baseline, acute, one week and two weeks
measure: Changes in blood pressure from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract
timeFrame: baseline, acute, one week and two weeks
measure: Changes in total peripheral resistance from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract
timeFrame: baseline, acute, one week and two weeks
Secondary outcomes:
measure: Changes in oxygen consumption from baseline with acute intake, one week and two weeks intake.
timeFrame: baseline, acute, one week and two weeks
measure: Changes in carbon dioxide production from baseline with acute intake, one week and two weeks intake.
timeFrame: baseline, acute, one week and two weeks
measure: Changes in respiratory exchange ratio from baseline with acute intake, one week and two weeks intake.
timeFrame: baseline, acute, one week and two weeks
measure: Changes in carbohydrate oxidation from baseline with acute intake, one week and two weeks intake.
timeFrame: baseline, acute, one week and two weeks
measure: Changes in fat oxidation from baseline with acute intake, one week and two weeks intake.
timeFrame: baseline, acute, one week and two weeks
Other outcomes:
Locations:
city: Chichester
country: United Kingdom
facility: Mark Willems
state: West Sussex
Study officials:
affiliation: University of Chichester
name: Mark E Willems, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Sahin PhD MA, Bilgic PhD P, Montanari MSc S, Willems PhD MET. Intake Duration of Anthocyanin-Rich New Zealand Blackcurrant Extract Affects Metabolic Responses during Moderate Intensity Walking Exercise in Adult Males. J Diet Suppl. 2021;18(4):406-417. doi: 10.1080/19390211.2020.1783421. Epub 2020 Jun 24.
citation: Sahin PhD MA, Bilgic PhD P, Montanari MSc S, Willems PhD MET. Daily and Not Every-Other-Day Intake of Anthocyanin-Rich New Zealand Blackcurrant Extract Alters Substrate Oxidation during Moderate-Intensity Walking in Adult Males. J Diet Suppl. 2022;19(1):49-61. doi: 10.1080/19390211.2020.1841356. Epub 2020 Oct 29.