Clinical trial NCT01580566: Renal Acute MI Study
Official title: Renal Structural, Functional and Cytokine Responses to Acute Myocardial Injury in Man
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Myocardial Infarction
Kidney Function
Keywords: Myocardial Infarction (MI)
Kidney function
bio-markers
Lead sponsor: Monash University
Sponsor class: OTHER
First posted: 2012-04-19
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients who have presented to the Emergency Department with chest pain caused by a possible myocardial infarction.

Brief summary: The purpose of this study is to determine if a sizable myocardial infarction (heart attack) results in negative changes to renal structure and function (i.e. has a negative impact on the kidneys).

To determine if the renal response to a myocardial infarction is a predictor of the patients future health.

Detailed description: Chronic heart and kidney disease are increasingly common in Western society. Both conditions are associated with frequent hospitalisation and increased mortality. Furthermore, there are mechanistic reasons why one condition may beget the other; the so-called "cardiorenal syndrome". The investigators therefore wish to determine if a sizable myocardial infarction (heart attack) results in negative changes to renal structure and function (i.e. has a negative impact on the kidneys). The investigators also wish to determine if the renal response to a myocardial infarction is a predictor of the patients future health. To do this the investigators will measure markers of kidney function at the time of the heart attach, at discharge, 1 month, 6 months and 12 months and correlate this with the patients clinical condition.

Eligibility criteria: Inclusion Criteria:

Age \> 18 years

Have provided written informed consent

Group 1:

* Non-Q wave MI patients
* normal cardiac and renal function
* No use of contrast
* eGFR \> 60ml/min

Group 2:

* Patients undergoing coronary angiography +/- PCI for stable CAD or non-Q wave MI
* normal cardiac and renal function
* eGFR \> 60ml/min

Group 3:

* Acute STEMI Full thickness infarct (STEMI)
* eGFR ≥ 60ml/min

Group 4:

* Acute STEMI Full thickness infarct (STEMI)
* eGFR \< 60ml/min

Exclusion Criteria:

* Unable or unwilling to comply with the study protocol
* Underlying medical condition which, in the opinion of the investigator, will effect the safely or efficacy of the study

Primary outcomes:
measure: changes in renal function and structure
timeFrame: Baseline, discharge, 1 month, 6 months and 12 months
Secondary outcomes:
measure: renal response to myocardial infarction
timeFrame: baseline, discharge, 1 month, 6 months and 12 months
Other outcomes:
Locations:
city: Melbourne
country: Australia
facility: Alfred Hospital
state: Victoria
Study officials:
affiliation: Alfred Hospital/Monash.University
name: Henry Krum, MBBS FRACP PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Alfred Hospital/Monash University
name: Henry Krum, MBBS FRACP PhD
role: PRINCIPAL_INVESTIGATOR
References: