Clinical trial NCT04341766: Evolution of Pulmonary Ultrasound in Patients Hospitalized for Covid (Coronavirus Disease) 19
Official title: Prospective Descriptive Study on the Evolution of Pulmonary Ultrasound in Patients Hospitalized for Covid19
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pneumonia, Viral
COVID-19
Lead sponsor: Centre Hospitalier Intercommunal Creteil
Sponsor class: OTHER
First posted: 2020-04-10
Enrollment: 106
Sex: ALL
Minimum age (years): 18
Maximum age (years): 105
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient admitted to hospital with proven COVID-19 infection with respiratory signs and who need an hospitalization

Brief summary: Clinical thoracic ultrasound plays an important role in the exploration, diagnosis and follow-up of thoracic pathologies.

The COVID (Coronavirus Disease) epidemic is leading to a large influx of patients in the emergency department with respiratory disorders. The rapid diagnosis of respiratory disorders in infected patients is important for further management.

Chest ultrasound has already demonstrated its value in the diagnosis of pneumonia in the emergency department with superiority over chest X-ray.

However, there is little data on the thoracic ultrasound semiology of viral pneumonia in general and of COVID in particular.

Detailed description: Chest ultrasound has already shown its value in the diagnosis of pneumonia in the emergency department with superiority over chest X-ray.

However, there is little data on the thoracic ultrasound semiology of viral pneumonia in general and of COVID in particular.

Peng reported data from 20 patients and compared them to chest CT. The abnormalities are a thickening of the pleuropneumonia line, an interstitial syndrome with B lines, corresponding to frosted glass opacities, confluent B lines (snowstorm appearance) corresponding to interstitial infiltrate, sub-pleural alveolar opacities corresponding to sub-pleural condensations, more frank alveolar images corresponding to alveolar opacities. A multifocal aspect was associated with involvement of more than 2 lobes. However, the frequency of these abnormalities as well as the sensitivity of the echo are not detailed in this article.

Another Italian article describes a clinical case of COVID-19 pneumonia with sub-pleural involvement and irregularity of the pleuro-pulmonary line.

Clinical thoracic ultrasound has a major potential interest during the COVID epidemic: available at the patient's bedside, avoiding the need to move around, feasible for the physician during his visit, easy to clean especially if ultraportable devices are used, fast and not exposing the staff any more than the usual clinical examination.

In order to determine whether this technique is useful in the management of infected patients or patients suspected of COVID-19 infection with respiratory signs, we propose a descriptive prospective study evaluating the ultrasound semiology of COVID-19 pneumonia and the interest of ultrasound in the evolutionary follow-up of these patients.

Eligibility criteria: Inclusion Criteria:

* Patients admitted to hospital with proven COVID-19 infection with respiratory signs warranting a chest CT scan

Exclusion Criteria:

* Patient not agreeing to have his or her data collected for the study
* Unconscious patient

Primary outcomes:
measure: Characteristics of pulmonary ultrasound for Covid-19 patients
timeFrame: Day one
Secondary outcomes:
measure: Characteristics of pulmonary ultrasound for Covid-19 patients
timeFrame: Day 3
measure: Characteristics of pulmonary ultrasound for Covid-19 patients
timeFrame: Day 14
measure: Charateristics of pulmonary CT-scan for Covid-19 patients
timeFrame: Day 1
measure: Charateristics of pulmonary CT-scan for Covid-19 patients
timeFrame: Day 3
measure: Charateristics of pulmonary CT-scan for Covid-19 patients
timeFrame: Day 14
Other outcomes:
Locations:
city: Amiens
country: France
facility: CHU Amiens
city: Bayonne
country: France
facility: CH de la Côte Basque
city: Boulogne-Billancourt
country: France
facility: CHU Ambroise Paré
city: Caen
country: France
facility: CHU Caen
city: Chambéry
country: France
facility: CHG de Chambery
city: Créteil
country: France
facility: Centre Hospitalier Intercommunal de Créteil
city: Limoges
country: France
facility: CHU de Limoges
city: Marseille
country: France
facility: APHM - Hopital Nord
city: Nancy
country: France
facility: CHU de Nancy
city: Nîmes
country: France
facility: CHU Nîmes
city: Orléans
country: France
facility: CHR Orléans
city: Paris
country: France
facility: CHU Cochin
city: Poitiers
country: France
facility: CHU Poitiers
city: Rouen
country: France
facility: CHU Rouen
city: Saint-Quentin
country: France
facility: CH Saint-Quentin
city: Toulouse
country: France
facility: CHU Larrey - Toulouse
city: Tours
country: France
facility: CHU de Tours
Study officials:
References: