Clinical trial NCT00889057: Sorafenib in Relapsed High Grade Osteosarcoma
Official title: Phase II, Open Label, Non-randomized Study of Second or Third Line Treatment With Sorafenib (BAY 43-9006) in Patients Affected by Relapsed High-grade Osteosarcoma.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Osteosarcoma
Keywords: osteosarcoma
sorafenib
target therapy
Lead sponsor: Italian Sarcoma Group
Sponsor class: NETWORK
First posted: 2009-04-28
Enrollment: 35
Sex: ALL
Minimum age (years): 15
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Aim of this exploratory phase II study is to assess the clinical activity of sorafenib as single agent, in terms of percentage of patients with high grade advanced osteosarcoma free from progression following 4 months of therapy


Eligibility criteria: Inclusion Criteria:

* histologically documented and not surgically resectable or metastatic high-grade osteosarcoma which progressed after first or second line treatments for relapsing disease.
* measurable disease as defined by having at least one lesion that can be accurately measured by means of CT or MRI.
* ECOG PS of 0, 1 and an estimated life expectancy of at least 3 months. ECOG P.S. 2 is acceptable provided that it depends solely on orthopedic problems
* Age ≥15 years.
* Adequate bone marrow, liver and renal function
* Written informed consent

Exclusion Criteria:

* Dementia or significantly altered mental status that would prohibit the understanding or rendering of informed consent and compliance with the requirements of this protocol.
* Coexisting malignancies, except for basal or epithelial cell carcinoma of the skin or other solid tumors curatively treated with no evidence of disease for ≥3 years.
* History of cardiac disease: congestive heart failure \>NYHA class 2; active CAD (MI more than 6 months prior to study entry is allowed); cardiac arrhythmias requiring anti-arrhythmic therapy (beta blockers or digoxin are permitted) or uncontrolled hypertension.
* History of HIV infection or chronic hepatitis B or C.
* Active clinically serious infections (\> grade 2 NCI-CTC version 3.0)
* Symptomatic metastatic brain or meningeal tumors (unless the patient is \> 6 months from definitive therapy, has a negative imaging study within 4 weeks of study entry and is clinically stable with respect to the tumor at the time of study entry)
* Patients with seizure disorders requiring medication (such as steroids or anti-epileptics)
* Pregnant or breast-feeding patients. Women of childbearing potential must have a negative pregnancy test performed within 7 days of the start of treatment. Both men and women enrolled in this trial must use adequate barrier birth control measures during the course of the trial and two weeks after the completion of trial.
* Patients with evidence or history of bleeding diathesis
* Patients undergoing renal dialysis
* Patients unable to swallow oral medications

Primary outcomes:
measure: Tumor assessment through radiologic evaluation.
timeFrame: every 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Candiolo
country: Italy
facility: I.R.C.C. - Unit of Medical Oncology
state: Torino
city: Bologna
country: Italy
facility: Istituti Ortopedici Rizzoli - Unit of Chemotherapy of Muscoloskeletal Tumors
city: Milano
country: Italy
facility: Istituto Nazionale Tumori - Unit of Medical Oncology
city: Torino
country: Italy
facility: Ospedale Infantile Regina Margherita - Unit of Paediatric Oncoematology
Study officials:
affiliation: I.R.C.C - FPO Candiolo
name: Massimo Aglietta, MD
role: STUDY_CHAIR
affiliation: I.R.C.C. - FPO Candiolo
name: Giovanni Grignani, MD
role: PRINCIPAL_INVESTIGATOR
References: