Clinical trial NCT04360291: Impact of Visual Field Restriction on Visual Exploration
Official title: Impact de la Restriction du Champ Visuel Sur l'Exploration Visuelle
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pigmentary Retinopathy
Lead sponsor: Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Sponsor class: OTHER
First posted: 2020-04-24
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects with pigmentary retinopathy

Brief summary: To communicate with the observer and guide his gaze on the canvas, painters have developed different stylistic processes that artists, in the manner of scientists, have acquired on the functioning of human visual perception. This direct communication between the artist and the observer is strongly impacted for people with visual impairments.

In order to improve the accessibility and autonomy of visually impaired people in museums and to allow each observer to feel the visual and emotional experience closest to the original work of the artist, it is essential to identify the modifications. perceptive generated by the constriction of vision

Detailed description: In this experiment, the investigators study the adaptive strategies developed by people with retinitis pigmentosa in the perception of figurative works of art. Peripheral vision is crucial for detecting objects and directing attention to the relevant areas of the environment, while central vision, of high spatial resolution, is especially essential for identifying the nature of objects. The integration of perceived information in peripheral vision and central vision makes it possible to quickly and effortlessly develop a spatial representation of the environment, to activate categorical knowledge on the observed scene and to relate the various objects perceived. However, with the progressive constriction of the visual field, the visual exploration of the subject RP can not be carried out with the strategies used by the healthy subjects, in which the targets of the saccades are in particular determined according to the information perceived in peripheral vision.

Through the recording of eye movements, the investigators compare the differences in visual explorations of people with retinitis pigmentosa and healthy people with or without a simulated deficit.

Eligibility criteria: Groupe 1

Inclusion Criteria:

* no visual pathology
* Age ≥ 18 and \<65 years
* Binocular visual acuity ≥8 / 10th or ≤ +0.10 logMAR
* Comprehension of the written and spoken French language
* Signed consent to participate in the study
* Health insurance affiliation
* Visit to an ophthalmologist less than a year old

Exclusion Criteria:

* Pregnant or lactating woman
* Ocular pathology that may interfere with planned assessments
* Treatment that may interfere with planned assessments
* Participation in another study that may interfere with this study.
* Severe pathology unbalanced or interfering with planned assessments.
* Neurological deficit including history of epileptic pathology, photosensitive epilepsy, sensory-motor coordination disorders, vestibular or cerebellar pathology
* Inability to give consent personally.
* Adults protected by law.

Groupe 2

Inclusion Criteria:

* Retinopathy pigmentary dystrophy rods-cones.
* Binocular visual acuity ≥4 / 10 (≤0.4 logMAR).
* Horizontal diameter of the residual Goldmann field of view ≤ 25 ° of binocular diameter at III4.
* Comprehension of the French language, written or oral.
* Signed consent
* Visual assessment less than 6 months old

Exclusion Criteria:

* Pregnant or nursing woman.
* Ocular pathology that may interfere with planned assessments.
* Treatment that may interfere with planned assessments.
* Severe pathology unbalanced or interfering with planned assessments.
* Participation in another study that may interfere with this study.
* Neurological deficit including antecedent of epileptic pathology, photosensitive epilepsies, non-visual sensory disturbances, motor disorders, or sensorimotor coordination disorders, vestibular or cerebellar pathology.
* Inability to give consent personally.
* Adults protected by law.

Primary outcomes:
measure: Eye movements
timeFrame: through study completion,, an average of 1 year
measure: Fixation strategy
timeFrame: through study completion,, an average of 1 year
measure: Target location accuracy
timeFrame: through study completion,, an average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Institut de la vision
Study officials:
affiliation: Institut de la vision
name: Avinoam Safran
role: PRINCIPAL_INVESTIGATOR
References: