Clinical trial NCT02867657: Bringing the Practice of Mindfulness Into Nature - Preventing Mental Fatigue in Healthcare Professionals.
Official title: Enhancement of Presence, Compassion and Resilience Bringing the Practice of Mindfulness Into Nature - Preventing Mental Fatigue in Healthcare Professionals.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stress, Psychological
Inflammation
Stress, Physiological
Lead sponsor: VIA University College
Sponsor class: OTHER
Collaborators: name: University of Copenhagen
name: University of Aarhus
First posted: 2016-08-16
Enrollment: 93
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of the study is to determine whether a five day mindfulness retreat in nature can increase measures of attention and self-compassion, and reduce stress among bachelor students at Danish Universities and University Colleges. Secondary whether the expression of inflammatory markers can be reduced .

It is the hypothesis that perceived stress is reduced and the expression of genetic markers of inflammation is reduced after a five day mindfulness retreat.


Eligibility criteria: Inclusion Criteria:

* Bachelor student at a Danish University or University College
* A score of 16 or above on the Perceived Stress Scale (PSS)

Exclusion Criteria:

* Smoking
* Psychiatric diagnosis (depression, anxiety, adjustment disorder, PTSD, personality disorder, psychosis).
* Untreated ADHD, autism, abuse and risk of suicide

Primary outcomes:
measure: Perceived Stress Scale
timeFrame: At the end of five days retreat
measure: Self-compassion
timeFrame: At the end of five days retreat
Secondary outcomes:
measure: Five Facet Mindfulness Questionnaire
timeFrame: At the end of five days retreat
measure: Breath Counting
timeFrame: At the end of five days retreat
measure: NF-kB gene expression
timeFrame: At the end of five days retreat
measure: IL-1 gene expression
timeFrame: At the end of five days retreat
measure: IL-6 gene expression
timeFrame: At the end of five days retreat
measure: cRP expression
timeFrame: At the end of five days retreat
measure: Heart Rate Variability
timeFrame: At the end of five days retreat
measure: Blood pressure
timeFrame: At the end of five days retreat
measure: Connectedness to Nature Scale
timeFrame: At the end of five days retreat
measure: GR gene expression
timeFrame: At the end of five days retreat
measure: RIPK2 gene expression
timeFrame: At the end of five days retreat
measure: TNF-α gene expression
timeFrame: At the end of five days retreat
measure: CCL5 gene expression
timeFrame: At the end of five days retreat
measure: IL-8 gene expression
timeFrame: At the end of five days retreat
measure: TERT gene expression
timeFrame: At the end of five days retreat
measure: TERC gene expression
timeFrame: At the end of five days retreat
measure: IL-1β protein expression
timeFrame: At the end of five days retreat
measure: IL-2 protein expression
timeFrame: At the end of five days retreat
measure: IL-4 protein expression
timeFrame: At the end of five days retreat
measure: IL-6 protein expression
timeFrame: At the end of five days retreat
measure: IL-8 protein expression
timeFrame: At the end of five days retreat
measure: IL-10 protein expression
timeFrame: At the end of five days retreat
measure: IL-12p70 protein expression
timeFrame: At the end of five days retreat
measure: IL-13 protein expression
timeFrame: At the end of five days retreat
measure: TNF-α protein expression
timeFrame: At the end of five days retreat
measure: IFN-γ protein expression
timeFrame: At the end of five days retreat
Other outcomes:
Locations:
city: Aarhus
country: Denmark
facility: VIA University College
city: Hoersholm
country: Denmark
facility: Nacadia, University of Copenhagen
Study officials:
References:
citation: Kunzler AM, Helmreich I, Konig J, Chmitorz A, Wessa M, Binder H, Lieb K. Psychological interventions to foster resilience in healthcare students. Cochrane Database Syst Rev. 2020 Jul 20;7(7):CD013684. doi: 10.1002/14651858.CD013684.