Clinical trial NCT05210491: The Effect of Varying Brightness on Palpebral Aperture
Official title: The Effect of Varying Brightness Levels on Palpebral Aperture and the Point of Orbicularis Engagement Using EEG Signalling.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Eyelid Ptoses
Keywords: Palpebral Aperture measurements
Lead sponsor: University of Edinburgh
Sponsor class: OTHER
Collaborators: name: National Health Service, United Kingdom
name: Royal Free Hospital NHS Foundation Trust
First posted: 2022-01-27
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: We aim to establish the point at which glare from bright lights begins to engage our eyelids - causing us to "squint". We will be using a video camera with an LED ring light around it facing the volunteer and we will record the eyelid position as the light brightness is increased gradually. Many studies have looked at the effect glare has on a person through qualitative questionnaires but few have been able to quantify this.

Detailed description: Our study will aim to establish the point of orbicularis engagement based on luminous intensity Murray et al. created an Ocular Stress Monitor to see if the contracture of the muscles on the eyelid indicative of pain as a light source was increased in luminosity 8 Our study will go one step further by using video technology and a portable EEG machine to detect the pulses of lid contracture as luminosity of a ring light i s increased incrementally. An advanced calibrated datalogging LED light meter will simultaneously record the level of brightness to establish at which point the spike in EEG occurs. Screenshots from the video recording will be taken and accurate MRD1 measurements can be taken at the point of orbicular i s engagement.

The scientific justification for this research question is twofold We wish to establish the threshold at which orbicularis engages such that palpebral aperture and MRD measurements are altered. This is relevant to the technique of taking these measurements in the clinical environment and the light intensity at which these measurements are taken. We wish to establish the light intensity which should not be exceeded to take these measurements. As photography becomes increasingly used in oculoplastic s clinics we envisage palpebral aperture and MRD1 measurements being performed digitally rather than manually These measurements are relevant to pre operative and post operative imaging, and surgical planning. Furthermore, our results maybe applicable more widely to industry, for example vehicle headlights, bicycle lights, camera flash, workplace lighting.

Reference: Murray I, Plainis S, Carden D. The ocular stress monitor: a new device for measuring discomfort glare. Lighting Research Technology. 2002;34(3):231 239.

Eligibility criteria: Inclusion Criteria:

* Aged between 18 and 65 years of age
* A member of the Royal Free NHS trust

Exclusion Criteria:

* No known ocular pathology
* No lid problems/ptosis or previous lid surgery
* No contact lenses in for duration of experiment
* No pseudophakia
* No neurological disease

Primary outcomes:
measure: The point at which the eyelid begins to contract under what brightness level
timeFrame: All carried out within a 2 week period
Secondary outcomes:
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: Ophthalmology, Royal Free Hospital
Study officials:
References: