Clinical trial NCT06712667: The Effect of Coffee on People with High Intensity Exercise and the Characteristics of Caffeine Metabolism
Official title: The Effect of Coffee on People with High Intensity Exercise and the Characteristics of Caffeine Metabolism
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Healthy
Keywords: Coffee
Caffeine
Exercise
Caffeine metabolism
Lead sponsor: Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Sponsor class: OTHER
First posted: 2024-12-02
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this project is to explore the relationship between the effect of coffee on exercise performance and caffeine metabolism.

Detailed description: The investigators will study the relationship between the impact of coffee on exercise and caffeine metabolism. The investigators will recruit healthy elite athletes. Participants will be forbidden to consume stimulant drinks such as coffee for 24 hours before the experiment. When the participants arrive at the lab on the day of the experiment, they will sign an informed consent form, a health history questionnaire and a daily coffee consumption questionnaire. Each participant does six rides, with one day of caffeine washout before each ride. In all trials, each participant will ride at the same time of day. Before riding, drink 200 ml water, decaffeinated coffee or coffee in random order, and the caffeine content of coffee is 200 mg. After 60 minutes of drinking, they start riding, after the completion of the riding, the subjects perceived and judged the perception between the baseline load and the comparison load. After the completion of the judgment, the next level of stimulus parameters will randomly generated to conduct the experiment. Each person conducted 6 groups of intervention experiments. Changes in average exercise performance, heart rate, electrocardiogram and body temperature will be observed after drinking decaffeinated coffee or coffee compared with drinking water. The concentration of caffeine and its metabolites in urine before and after drinking within 3 hours will be measured by liquid chromatography-mass spectrometry (LC-MS) or gas chromatography-mass spectrometry (GC-MS).

Eligibility criteria: Inclusion Criteria:

Healthy adults 18-40 years old

Exclusion Criteria:

Diabetes Hypoglycemia Gout Osteoporosis Gastric ulcer Pancreatitis Intestinal obstruction Blood phobia Pathological hypo or hyper tension Impaired glucose tolerance Claustrophobia HIV,etc.

Primary outcomes:
measure: Exercise performance
timeFrame: On the experimental day, it lasts 2 weeks.
measure: Urine metabolites
timeFrame: On the experimental day, it lasts 2 weeks.
Secondary outcomes:
measure: Body temperature
timeFrame: On the experimental day, it lasts 2 weeks.
measure: Electrocardiogram (ECG)
timeFrame: On the experimental day, it lasts 2 weeks.
measure: Blood pressure
timeFrame: On the experimental day, it lasts 2 weeks.
measure: Height
timeFrame: The morning of the first day of the experiment, 5 mins
measure: Body weight
timeFrame: The morning of the first day of the experiment, 5 mins
measure: Fat mass
timeFrame: The morning of the first day of the experiment, 10 mins
measure: Fat free mass
timeFrame: The morning of the first day of the experiment, 10 mins
measure: Bone mass
timeFrame: The morning of the first day of the experiment, 10 mins
measure: Heart rate
timeFrame: 2 weeks
measure: Waist circumferences
timeFrame: The morning of the first day of the experiment,10 mins
Other outcomes:
Locations:
city: Shenzhen
country: China
facility: Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
state: Guangdong
Study officials:
affiliation: Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
name: John R Speakman, PhD
role: STUDY_CHAIR
References: