Clinical trial NCT06595394: Effect of Combined Exercise Training in Patients With Multiple Sclerosis
Official title: Investigation of the Effect of Exercise Training in Patient With Sarcopenic Multiple Sclerosis
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Multiple Sclerosis
Keywords: Sarcopenia
Exercise
Lead sponsor: Uskudar University
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this clinical trial is exercise in sarcopenic MS patients to demonstrate the effectiveness of education. The main questions it aims to answer are: -Can exercise training make a change in muscle thickness in sarcopenic MS patients?

--Does exercise training have an effect on balance in sarcopenic MS patients?

- Does exercise training have an effect on the risk of falling in sarcopenic MS patients?

Participants will:

They will continue combined exercise applications 3 days a week for 8 weeks. Evaluations will be made before the application and at the end of the 8 weeks. The data will be analyzed afterwards.

Detailed description: A significant decrease in physical performance is observed in MS patients. The reasons for this can be changes in muscle contractile structures and symptoms such as sarcopenia. Sarcopenia is a disorder characterized by loss of skeletal muscle mass and decrease in muscle strength and physical performance. Loss of muscle mass seen outside of old age is defined as secondary sarcopenia. In recent years, studies on neurological disorders and their relationship with sarcopenia have increased. Early diagnosis of sarcopenia in neurological patients and implementation of applications aimed at this are important from an early stage. The aim of this study is to examine the effect of exercise training in sarcopenic MS patients. In the study, participants will be applied a combined exercise program 3 days a week for 8 weeks. Parameters such as muscle thickness, balance, and fall risk will be evaluated before and after physiotherapy application including aerobic exercise, balance exercises, and strengthening exercises.

Eligibility criteria: Inclusion Criteria:

* People diagnosed with MS by a neurologist
* People with ambulation whose EDSS is 4.5 or below
* People between the ages of 18-50
* People who do not exercise regularly and are not included in an exercise program

Exclusion Criteria:

* Having been diagnosed with sarcopenia before MS diagnosis
* Having had an MS attack within the last 30 days
* Having any musculoskeletal problems that may affect walking and balance
* Having a diagnosed psychiatric disease that may affect cognitive status
* Having a neurological disease other than MS

Primary outcomes:
measure: Muscle thickness
timeFrame: 8 weeks
Secondary outcomes:
measure: SARC -F
timeFrame: 8 weeks
measure: Hand grip strength measurement
timeFrame: 8 weeks
measure: Bioelectrical impedance analysis
timeFrame: 8 weeks
measure: Timed Up and Go (TUG)
timeFrame: 8 weeks
measure: Berg Balance Scale (BBS)
timeFrame: 8 weeks
measure: Fatigue Severity Scale (FSS)
timeFrame: 8 weeks
measure: 6 Minute Walk Test
timeFrame: 8 weeks
Other outcomes:
Locations:
Study officials:
affiliation: Hacettepe University
name: Sibel Aksu Yıldırım, Prof.
role: PRINCIPAL_INVESTIGATOR
References: