louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04944667: Use of Virtual Reality for Procedural Planning of Transcatheter Aortic Valve Replacement
Official title: Use of Virtual Reality for Procedural Planning of Transcatheter Aortic Valve Replacement (TAVR)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aortic Stenosis, Severe
Lead sponsor: Centro Medico Teknon
Sponsor class: OTHER
Collaborators: name: Techer Team SL. Valencia. Spain
First posted: 2021-06-29
Enrollment: 11
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: This study sought to evaluate the impact of Virtual Reality (VR) tools in procedural planning of transcatheter aortic valve replacement (TAVR).

Detailed description: A prospective study involving 11 patients referred for TAVR was conducted. A multidetector computed tomography (MDCT) was used to acquire and segment the anatomy of the access route and landing zone. From the information obtained with the MDCT in DICOM format, the investigators built a virtual platform (VisuaMed, Teacher Team. Valencia. Spain) that contains all the clinical information of the patients and a virtualized model of their anatomy. Wearing VR devices, the professional was able to "walk inside " the anatomy in an interactive and immersive way. Decisions after the evaluation of routine clinical images were compared with those after experience with VR models and intraprocedural findings.

Eligibility criteria: Inclusion Criteria:

* Severe aortic stenosis considered for TAVR procedure at a single Institution

Exclusion Criteria:

* None

Primary outcomes:
measure: TAVR procedure planning (prosthesis size, implant technique requirements, potential risks)
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: CentroMT (Centro Médico Teknon)
Study officials:
References:
Clinical trial NCT05042167: The Effect of Resistance Exercise on Inflammation in Young and Older Adults
Official title: The Acute Effect of High-load Resistance Exercise on Inflammation in Young and Older Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aging
Inflammatory Response
Lead sponsor: National Taiwan Normal University
Sponsor class: OTHER
First posted: 2021-09-13
Enrollment: 16
Sex: MALE
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Healthy young and older adults will complete two trials in a randomized crossover counter-balanced order, including resistance exercise and sedentary control. During each trial, blood samples will be collected.

The investigators hypothesized that an acute bout of resistance exercise exert different inflammation responses in young and older adults.


Eligibility criteria: Inclusion Criteria:

* Age: 20-80
* Healthy male
* Without experience of resistance training

Exclusion Criteria:

* No acute or chronic musculoskeletal symptoms
* Smoking
* Alcohol or drug abuse
* Fail to conduct resistance exercise

Primary outcomes:
measure: Changes in biomarkers of inflammation
timeFrame: 24-hour during each study intervention
Secondary outcomes:
measure: Changes in glucose
timeFrame: 24-hour during each study intervention
measure: Changes in metabolic parameters
timeFrame: 24-hour during each study intervention
measure: Changes in biomarkers of muscle damage
timeFrame: 24-hour during each study intervention
measure: Changes in molecular markers in peripheral blood mononuclear cells (PBMC)
timeFrame: 24-hour during each study intervention
measure: Changes in complete blood count (CBC)
timeFrame: 24-hour during each study intervention
measure: Borgs Ratings of Perceived Exertion (RPE)
timeFrame: 1-hour during each exercise intervention
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan Normal University
Study officials:
affiliation: National Taiwan Normal University
name: Hung-Wen Liu, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05368467: National Registry and Cohort Study of Pulmonary Vascular Disease
Official title: National Registry and Cohort Study of Pulmonary Vascular Disease
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Pulmonary Arterial Hypertension
Lead sponsor: Nanjing First Hospital, Nanjing Medical University
Sponsor class: OTHER
First posted: 2022-05-10
Enrollment: 1000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with Pulmonary Hypertension from China based PH centers.

Brief summary: This is a observational、multicenter, prospective cohort study for patients with pulmonary hypertension (PH). The purposes of this study were to evaluate the etiology、clinical characteristics、treatment modalities, and outcomes of patients with PH；also to set up registration system of PH in China, to build a database of Chinese PH, to establish a web-based international standard data acquisition system for PH and a multicenter clinical research platform. The results of the study will provide a basis for the future national health policy for prevention and treatment of PH.


Eligibility criteria: Inclusion Criteria:

* Newly diagnosed or previously diagnosed patients with PH.
* Documentation of mean pulmonary arterial pressure (mPAP) \>20 mm Hg by right heart catheterization, performed at any time prior to study enrollment.

Exclusion Criteria:

* Have not had documentation of hemodynamic criteria for PH by right heart catheterization at some time preceding study entry and following development of symptoms associated with PH.
* Do not meet the required hemodynamic criteria for entry into the study.

Primary outcomes:
measure: All-cause Death
timeFrame: 5 years
Secondary outcomes:
measure: Number of Participants with Clinical Worsening
timeFrame: 5 years
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Guangdong Provincial Peoples Hospital
state: Guangdong
city: Nanjing
country: China
facility: Nanjing First Hospital
state: Jiangsu
city: Tianjin
country: China
facility: General Hospital of Tianjin Medical University
state: Tianjin
city: Beijing
country: China
facility: Beijing Anzhen Hospital of Capital Medical University
city: Beijing
country: China
facility: China-japan Friendship Hospital
city: Changsha
country: China
facility: Xiangya Second Hospital, Central South University
city: Chendu
country: China
facility: West China Hospital, Sichuan University
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital
city: Shenyang
country: China
facility: General Hospital of Northen Theater of Command
city: Wuhan
country: China
facility: Tongji Hospital, Huazhong University of Science and Technology
city: Wuhan
country: China
facility: Zhongnan Hospital of Wuhan University
city: Xi'an
country: China
facility: First Affiliated Hospital of Xi'An Jiaotong University
city: Zhengzhou
country: China
facility: First Hospital of Zhengzhou University
Study officials:
References:
Clinical trial NCT01666067: Vascular and Metabolic Effects of Vytorin vs Simvastatin
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Hypercholesterolemia
Keywords: insulin resistance
Lead sponsor: Gachon University Gil Medical Center
Sponsor class: OTHER
First posted: 2012-08-16
Enrollment: 204
Sex: ALL
Minimum age (years): 25
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators hypothesize that vytorin will improve insulin resistance compared with simvastatin


Eligibility criteria: Inclusion Criteria:

* hypercholesterolemic patients (LDL cholesterol levels\>100 mg/dl)

Exclusion Criteria:

* overt liver disease, chronic renal failure, hypothyroidism, myopathy, uncontrolled diabetes (HbA1c \> 9%), severe hypertension, stroke, acute coronary events, coronary revascularization within the preceding 3 months, or alcohol abuse

Primary outcomes:
measure: flow-mediated dilation
timeFrame: 8 weeks of treatment
Secondary outcomes:
measure: insulin resistance
timeFrame: 8 weeks of treatment
Other outcomes:
Locations:
city: Incheon
country: Korea, Republic of
facility: Gil Medical Center
Study officials:
References:
Clinical trial NCT03651167: Skin Tone Preferences and Their Influence on Skin Care Behaviors
Official title: Skin Tone Preferences and Their Influence on Skin Care Behaviors
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dermatology/Skin - Other
Keywords: skin care
skin tone
tanning
skin tone preference
Lead sponsor: Northwestern University
Sponsor class: OTHER
First posted: 2018-08-29
Enrollment: 619
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Adult self-identified minorities (African, Asian, Hispanic/Latino, American Indian, Alaskan native, etc.)

Brief summary: The purpose of this study is to classify participants by actual skin tone and skin tone preference and identify whether an association exists between these skin tone preferences and knowledge of skin care recommendations, attitudes towards healthy skin care, or skin care behaviors.

Detailed description: This study seeks to examine if there is a difference between ideal and actual skin tone among minority populations. In addition, we hope to assess whether various demographic factors as well as disparity between ideal and actual skin tone effect skin protective behaviors (i.e. sun screen use, dermatologist appointments, skin self-exams) or skin destructive behaviors (i.e. outdoor tanning, tanning salon use, use of skin lightening products) in minority populations.

Eligibility criteria: Inclusion Criteria:

* Subjects age 18 years old or older
* Self-identified members of a minority (African, Asian, Hispanic/Latino, American Indian, Alaskan native, etc.) population
* Subjects who are capable of completing an online, English survey

Exclusion Criteria:

* Subjects age 17 years old or younger
* Subjects not self-identified members of a minority (African, Asian, Hispanic/Latino, American Indian, Alaskan native, etc.) population
* Subjects who are incapable of completing an online, English survey

Primary outcomes:
measure: Frequency of skin tone differences between ideal and actual
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Northwestern University Feinberg School of Medicine Department of Dermatology
state: Illinois
Study officials:
References:
Clinical trial NCT03941067: Effects of Pre-event Massage Over the Neuromuscular Response
Official title: Effects of Pre-event Massage Over the Neuromuscular Response of Gastrocnemius Muscles
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Neuromuscular Diseases
Keywords: Neuromuscular response
pre-competition massage
pre-event massage
Lead sponsor: Universitat Internacional de Catalunya
Sponsor class: OTHER
First posted: 2019-05-07
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study observes the effect of a pre-event massage on the gastrocnemius muscles over the neuromuscular response of the gastrocnemious muscles.


Eligibility criteria: Exclusion Criteria:

* Muscle injury in the last two months
* To not understand the study orders
* Suffer a musculoskeletal disorder that doesn't allow the subject to do the study protocol

Primary outcomes:
measure: Delay time change
timeFrame: 2 minutes before the intervention, and 8 minutes after the intervention
measure: Contraction time change
timeFrame: 2 minutes before the intervention, and 8 minutes after the intervention
measure: Sustain time change
timeFrame: 2 minutes before the intervention, and 8 minutes after the intervention
measure: Relaxation time change
timeFrame: 2 minutes before the intervention, and 8 minutes after the intervention
measure: Maximal displacement change
timeFrame: 2 minutes before the intervention, and 8 minutes after the intervention
Secondary outcomes:
measure: Gastrocnemious strength change
timeFrame: 8 minutes before the intervention, and 2 minutes after the intervention
measure: Passive ankle dorsiflexion change
timeFrame: 6 minutes before the intervention, and 4 minutes after the intervention
measure: Jump height change
timeFrame: 10 minutes before the intervention, and 1 minute after the intervention
measure: Stiffness change
timeFrame: 5 minute before the intervention, and 5 minute after the intervention
measure: Elasticity change
timeFrame: 5 minute before the intervention, and 5 minute after the intervention
measure: Relaxation change
timeFrame: 5 minute before the intervention, and 5 minute after the intervention
Other outcomes:
Locations:
city: Sant Cugat Del Vallès
country: Spain
facility: Universitat Internacional de Catalunya
state: Barcelona
Study officials:
affiliation: Universitat Internacional de Catalunya
name: Albert Pérez-Bellmunt
role: PRINCIPAL_INVESTIGATOR
References:
citation: Perez-Bellmunt A, Labata-Lezaun N, Llurda-Almuzara L, Rodriguez-Sanz J, Gonzalez-Rueda V, Bueno-Gracia E, Celik D, Lopez-de-Celis C. Effects of a Massage Protocol in Tensiomyographic and Myotonometric Proprieties. Int J Environ Res Public Health. 2021 Apr 8;18(8):3891. doi: 10.3390/ijerph18083891.
Clinical trial NCT06344767: Positive ER Expression Assessed by 18F-FES PET/CT in the MBC with ER-negative Primary Tumor
Official title: Positive Estrogen Receptor (ER) Expression Assessed by 18F-fluoroestradiol Positron Emission Tomography/Computed Tomography (18F-FES PET/CT) in the Metastatic Breast Cancer (MBC) with ER- Negative Primary Tumor
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Breast Cancer
Lead sponsor: Fudan University
Sponsor class: OTHER
First posted: 2024-04-03
Enrollment: 19
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: MBC patients with ER-negative primary tumor who detected positive ER expression in metastatic disease using 18F-FES PET/CT at the Fudan University Shanghai Cancer Center

Brief summary: To investigate the treatment pattern and efficacy of patients with negative primary ER lesion but positive ER expression in MBC using a novel convenient way of 18F-fluoroestradiol positron emission tomography/computed tomography (18F-FES PET/CT).


Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with breast cancer (according to International Classification of Diseases 10th Revision) with confirmed metastasis, regardless of being de novo diagnosed or progressed from a nonmetastatic stage.
* MBC patients who underwent 18F-FES PET/CT at the Fudan University Shanghai Cancer Center between 2012 and 2023
* Patients diagnosed with primary ER-negative tumor and who were yet to receive any systemic therapy during the advanced stage

Exclusion Criteria:

Patients with incomplete medical records and those diagnosed with secondary primary tumors

Primary outcomes:
measure: Progression free survival (PFS)
timeFrame: 6 weeks
Secondary outcomes:
measure: Adverse events
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Shanghai
country: China
facility: China,Shanghai
state: Shanghai
Study officials:
References:
Clinical trial NCT06842667: Development and Preliminary Testing of a "Papageno"-Story Interview Intervention- Aim 3
Official title: Development and Preliminary Testing of a "Papageno"-Story Interview Intervention- Aim 3
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Suicide Prevention
Lead sponsor: University of Michigan
Sponsor class: OTHER
Collaborators: name: American Foundation for Suicide Prevention
name: Ouida Scholar Award
First posted: 2025-02-24
Enrollment: 600
Sex: ALL
Minimum age (years): 18
Maximum age (years): 24
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to determine the effects of a short "Papageno story" video of a compilation of interviews on proximal risk factors for suicide. The researchers believe that the intervention may increase protective factors related to suicide.


Eligibility criteria: Inclusion Criteria:

* People who are part of an existing cohort within DesignXM
* They will also answer yes to the question: "In the past 1 year, have you wished you were dead or wished you could go to sleep and not wake up?"

Exclusion Criteria:

* No exclusions if all inclusion criteria is met

Primary outcomes:
measure: Suicidal ideation
timeFrame: Immediately before and after watching the video and at 3 months
measure: Hopelessness
timeFrame: Immediately before and after watching the video and at 3 months
Secondary outcomes:
measure: Participant perceived agency
timeFrame: Immediately before and after watching the video and at 3 months
measure: Participant perception that help is available
timeFrame: Immediately before and after watching the video and at 3 months
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
Study officials:
affiliation: University of Michigan
name: Jane Harness, DO
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Michigan
name: Cheryl King, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02735967: The Use of Diadynamic in Association With a Manual Therapy Program for Patients With Impingement Syndrome
Official title: The Use of Diadynamic in Association With a Manual Therapy Program for Patients With Impingement Syndrome: a Randomized Blind Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Shoulder Impingement Syndrome
Lead sponsor: University of Nove de Julho
Sponsor class: OTHER
First posted: 2016-04-13
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 59
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study will be to evaluate the effects of the use of manual therapy and diadynamic in muscle trigger points in the upper trapezius muscle in individuals diagnosed with shoulder impingement syndrome, unilateral shoulder as functional capacity, pain intensity and pain threshold the pressure.


Eligibility criteria: Inclusion Criteria:

* history of anterior lateral and unilateral shoulder pain
* with more than 3 months duration
* intensity of at least 4 points on the Numerical Rating Pain Scale
* positivity in at least 2 of 3 orthopedic tests for impingement syndrome: Neer, Hawkins or Jobe
* Associated with these characteristics volunteers should submit myofascial trigger points unilateral and active, centrally located in the trapezius muscle descending fibers associated with painful shoulder

Exclusion Criteria:

* diagnosis of bilateral impingement syndrome shoulder
* fibromyalgia
* muscle injury
* history of trauma on the shoulder
* ruptured tendons
* ligamentous laxity
* symptoms of numbness and / or tingling in the upper limbs
* corticosteroid injection use shoulder
* making use of anti-inflammatory
* they performed surgery or physical therapy treatment in the last 6 months in the affected shoulder.

Primary outcomes:
measure: shoulder disability
timeFrame: Change from Baseline in the Shoulder Pain and Disability Index at 4 weeks
Secondary outcomes:
measure: intensity of pain
timeFrame: Change from Baseline in The Numerical rating pain scale at 4 weeks
measure: level of pressure pain
timeFrame: change from Baseline in ThePressure Pain Threshold at 4 weeks
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Cid André Fidelis de Paula Gomes
Study officials:
References:
Clinical trial NCT03586167: Clinical Performance of a Monthly Replacement Silicone Hydrogel Lens
Official title: Clinical Performance of a Monthly Replacement Silicone Hydrogel Lens
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Refractive Errors
Lead sponsor: Alcon Research
Sponsor class: INDUSTRY
First posted: 2018-07-13
Enrollment: 88
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the clinical performance of an investigational, coated silicone hydrogel contact lens over approximately 30 days of daily wear.


Eligibility criteria: Inclusion Criteria:

* Able to understand and sign an informed consent form approved by an Institutional review board (IRB);
* Successful wear of spherical monthly replacement soft contact lenses in both eyes for a minimum of 5 days per week and 8 hours per day during the past 3 months;
* Best-corrected visual acuity (BCVA) 20/25 or better in each eye;
* Willing to stop wearing habitual contact lenses for the duration of study participation.

Exclusion Criteria:

* Any conditions or use of medications that could contraindicate contact lens wear;
* History of or plan to have refractive surgery in either eye;
* Irregular cornea in either eye;
* Ocular or intraocular surgery (excluding placement of punctal plugs) within the previous 12 months or planned during the study;
* Current or history of intolerance, hypersensitivity or allergy to any component of the study products;
* Wearing habitual contact lenses in an extended wear modality (routinely sleeping in lenses for at least 1 night per week) over the last 3 months prior to enrollment;
* Use of topical ocular medications and artificial tear or rewetting drops requiring instillation during contact lens wear;
* Habitual Biofinity contact lens wearers.

Primary outcomes:
measure: Distance Visual Acuity (VA)
timeFrame: Day 30
Secondary outcomes:
Other outcomes:
Locations:
city: Maitland
country: United States
facility: Alcon Investigative Site
state: Florida
city: Johns Creek
country: United States
facility: Alcon Investigative Site
state: Georgia
city: Bloomington
country: United States
facility: Alcon Investigative Site
state: Illinois
city: Memphis
country: United States
facility: Alcon Investigative Site
state: Tennessee
Study officials:
affiliation: Alcon Research
name: Alcon Research
role: STUDY_DIRECTOR
References: