louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06715774: Impact of Twin Block and Motion Class II Appliances on Hyoid Bone Position - A Retrospective Clinical Study
Official title: Impact of Twin Block and Motion Class II Appliances on Hyoid Bone Position - A Retrospective Clinical Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hyoid Bone
Keywords: Hyoid bone, twin block, motion,
Lead sponsor: University of Salamanca
Sponsor class: OTHER
First posted: 2024-12-04
Enrollment: 82
Sex: ALL
Minimum age (years): 10
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children bewten 10-16 years old

Brief summary: Analyse the impact Twin block appliance and Motion on Hyoid Bone

Detailed description: Patients were selected, divided en two homogenous groups and underwent preoperative and postoperative lateral teleradiograph scans. The datasets were subsequently uploaded into a digital treatment planning software to record the position changes of the hyoid bone at horizontal, vertical, angular, and airway complex level; additionally, the effect of gender, age at onset, treatment time, biotype, and their interactions with the group, have been also statistically evaluated.

Eligibility criteria: Inclusion Criteria:

* 10 and 16 years old, with sketelal class II, a ANB angle ≥4° according to the Steiner cephalometric analysis, with Twin block or Motion appliance

Exclusion Criteria:

* without previous orthodontic treatment, without systemic disesases and adenotonsillar hypertrophy.

Primary outcomes:
measure: Impact of Twin Block and Motion Class II Appliances on Hyoid Bone Position - A Retrospective Clinical Study
timeFrame: 2023-2024
Secondary outcomes:
Other outcomes:
Locations:
city: Salamanca
country: Spain
facility: University of Salamanca
Study officials:
References:
Clinical trial NCT06628674: Developing and Testing the Effect of Online Interactive Videos in Improving Low Anterior Resection Syndrome.
Official title: Developing and Testing the Effect of Online Interactive Videos in Improving Low Anterior Resection Syndrome, Psychological Distress,and Quality of Life
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Rectal Cancer
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2024-10-08
Enrollment: 110
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study aims to develop and test the effect of online interactive videos in improving LARS.


Eligibility criteria: Inclusion Criteria:

1. Stage I-III rectal cancer.
2. Patients already know their condition.
3. Aged 20 years and older.
4. Consciously communicate in Mandarin or Taiwanese.
5. Agreed with the interview and had signed the permit.

Exclusion Criteria:

1. Recurrent rectal cancer.
2. Stage IV rectal cancer.

Primary outcomes:
measure: Self-report Questionnaire
timeFrame: Change from baseline symptom to 6 months after intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Taoyuan
country: Taiwan
facility: Chang Gung Memorial Hospital, Linkou
state: 中和區
Study officials:
References:
Clinical trial NCT04254874: A Prospective/Retrospective,Randomized Controlled Clinical Study of Interferon Atomization in the 2019-nCoV Pneumonia
Official title: An Open, Prospective/Retrospective, Randomized Controlled Cohort Study to Compare the Efficacy of Two Therapeutic Schemes(Abidol Hydrochloride,Abidol Hydrochloride Combined With Interferon Atomization)in the Treatment of 2019-nCoV Pneumonia.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: 2019-nCoV
Lead sponsor: Tongji Hospital
Sponsor class: OTHER
First posted: 2020-02-05
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: At present, there is no specific and effective antiviral therapy.In this study, an open, prospective/retrospective, randomized controlled cohort study was designed to compare the efficacy of two therapeutic schemes(abidol hydrochloride,abidol hydrochloride combined with interferon atomization)in the treatment of 2019-nCoV viral pneumonia, so as to provide reliable evidence-based medicine for the treatment of viral pneumonia caused by 2019-nCoV.


Eligibility criteria: Inclusion Criteria:

1)2019-nCoV nucleic acid test was positive. 2)CT of the lung conformed to the manifestation of viral pneumonia.

Exclusion Criteria:

1. Patients who meet any of the contraindications in the experimental drug labeling
2. Patients who do not want to participate in this clinical study

Primary outcomes:
measure: Rate of disease remission
timeFrame: two weeks
measure: Time for lung recovery
timeFrame: two weeks
Secondary outcomes:
measure: Rate of no fever
timeFrame: two weeks
measure: Rate of respiratory symptom remission
timeFrame: two weeks
measure: Rate of lung imaging recovery
timeFrame: two weeks
measure: Rate of CRP,ES,Biochemical criterion (CK,ALT,Mb)recovery
timeFrame: two weeks
measure: Rate of undetectable viral RNA
timeFrame: two weeks
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Department and Institute of Infectious Disease
state: Hubei
Study officials:
References:
Clinical trial NCT04776174: Efficacy and Tolerance of Telerobotic vs Standard Ultrasound Exam in Children
Official title: Crossover Comparison of the Efficacy and Tolerance of Telerobotic vs Standard Ultrasound Exam in Children
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Covid19
Lead sponsor: Centre Hospitalier Intercommunal Creteil
Sponsor class: OTHER
Collaborators: name: ADECHOTECH
First posted: 2021-03-01
Enrollment: 40
Sex: ALL
Minimum age (years): 1
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Children will be initially scanned with a telerobotic ultrasound system. Within 3 hours after the telerobotic examination, patients will be scanned by a different sonographer with similar experience and qualifications using the conventional ultrasound, who will be blinded to the findings of the telerobotic examination.
Primary purpose: DIAGNOSTIC

Brief summary: In children with Covid-19, the diagnosis of Kawasaki Disease (KD) and pneumonia should be made very quickly. However, the regional hospitals surrounding Paris don't have the required expertise. The use of MELODY allows the paediatric team to quickly carry out the necessary examinations while avoiding the movement of patients and the risk of contamination.

The MELODY remote system developed by the company AdEchoTech is a CE marking telemedicine technique, allowing an expert to perform an ultrasound scan on a distant patient (several hundred/thousands of kms). The Melody system makes it possible to optimize ultrasound expertise resources wherever they are located (all specialties combined) The feasibility of the clinical use of telerobotic sonography has been demonstrated in adults for abdominal, cardiac and prenatal exam. Thus, the aim of this study is to assess the feasibility of this system in children.


Eligibility criteria: Inclusion Criteria:

* Patient from 1 year to 10 years
* Patient requiring an ultrasound exam (thoracic, abdominal or cardiac)
* French social security affiliation

Exclusion Criteria:

* Obesity defined by a BMI greater than 30
* Open wound making it impossible to carry out an ultrasound scan
* Algetic patient
* Instability of vital functions
* Impossible to remain in a seated position
* Refusal to participate in the study

Primary outcomes:
measure: Number of normal and abnormal standard and telerobotic ultrasound examinations
timeFrame: 1 day
Secondary outcomes:
measure: Age of participants
timeFrame: At baseline
measure: Number of anomalies found
timeFrame: Up to 4 hours
measure: Parent satisfaction
timeFrame: Up to 4 hours
measure: Medical assistant satisfaction
timeFrame: Up to 4 hours
measure: Sonographer satisfaction
timeFrame: Up to 4 hours
Other outcomes:
Locations:
city: Créteil
country: France
facility: CHI Créteil
city: Villeneuve-Saint-Georges
country: France
facility: CHI Villeneuve-Saint-Georges
Study officials:
References:
Clinical trial NCT02195674: EMBARK Follow-up Project
Official title: Exploring Massage Benefits for Arthritis of the Knee (EMBARK): Post-study Massage Questionnaire
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Osteoarthritis of the Knee
Lead sponsor: Duke University
Sponsor class: OTHER
Collaborators: name: National Center for Complementary and Integrative Health (NCCIH)
First posted: 2014-07-21
Enrollment: 240
Sex: ALL
Minimum age (years): 35
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants in the EMBARK parent study.

Brief summary: The purpose of the EMBARK Follow-up Project (EFP) is to determine if there is a significant correlation between post-study massage-seeking and changes in pain reported by participants during the Exploring Massage Benefits for Osteoarthritis of the Knee (EMBARK) parent study (NCT00970008). The EFP hypothesizes that a positive correlation exists between pain relief during the parent study and post-study massage-seeking behavior.


Eligibility criteria: Inclusion Criteria:

* Completed in the EMBARK parent study.

Exclusion Criteria:

* Did not complete the EMBARK parent study.

Primary outcomes:
measure: EMBARK Follow-up Project Questionnaire (EFPQ)
timeFrame: Eight weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Duke University
name: Adam I Perlman, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00262574: Effect of BNP (Brain Natriuretic Peptides) on Endothelial Dysfunction Induced by Coronary Angioplasty
Official title: Phase 4 Study of Patients Receiving BNP or NTG (IV) During Angioplasty, Re-examined 24 Hours Later Using the Flow-mediated Brachial Artery Dilation Study, and Blood Assays for Pro BNP and ET1
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Coronary Artery Disease
Keywords: endothelial disfunction
BNP
PCI
coronary artery disease
Lead sponsor: The Baruch Padeh Medical Center, Poriya
Sponsor class: OTHER_GOV
First posted: 2005-12-07
Enrollment: 500
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: Patients receiving BNP or nitroglycerin (IV) during the angioplasty procedure. 24 h after the procedure, vascular reactivity will be re-examined using the brachial artery flow-mediated dilatation study. Blood assays for ET-1, pro-BNP, and various inflammatory markers will be checked before and 24 h after the procedure. It is our hypothesis that endothelial function will be better in the BNP treated patients compared to the NTG treated patients


Eligibility criteria: Inclusion Criteria:coronary artery disease -

Exclusion Criteria:CHF and/or reduced LV function, or renal failure with Creatinine \>2mg%

-

Primary outcomes:
measure: FMD
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Tiberias
country: Israel
facility: The Baruch Pade medical center, Poriya
Study officials:
affiliation: Ministry of Health, Israel
name: Mina Arinos
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00071474: Shamanic Healing for Women With Temporomandibular Joint Disorders (TMDs)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Temporomandibular Disorders
Keywords: temporomandibular disroders
shamanism
chronic pain
Lead sponsor: National Center for Complementary and Integrative Health (NCCIH)
Sponsor class: NIH
First posted: 2003-10-24
Enrollment: 25
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a Phase I study to examine the feasibility and safety of shamanic (spiritual) healing for treating temporomandibular joint disorders (TMDs).

Detailed description: Traditional systems of healing, such as shamanism, do not readily lend themselves to conventional research methods, yet studying their effectiveness is especially germane in the case of chronic conditions that involve an emotional component and that elude allopathic treatment regimens. Temporomandibular joint disorders (TMDs), which affect up to 10% of the adult population, are a prime example of such conditions. Traditional treatment outcomes for TMD pain are often unsatisfactory. Moreover, in women age 25-55 (the age-sex group most affected), TMD is often found in association with depression, anxiety, sleep disturbances, gastrointestinal symptoms, frequent infection,and fibromyalgia. Because these multiple and complex symptoms suggest a loss of spirit or life energy, they may be particularly susceptible to treatment by shamanic (spiritual) healing, which aims to bring disturbed physical, mental, and emotional systems into balance. This phase I study will develop methods to evaluate shamanic healing as an intervention for TMD and will evaluate the feasibility of conducting randomized clinical trials of shamanic healing.

Eligibility criteria: Inclusion criteria:

* Females Age 25-55
* TMD Research Diagnosis Criteria (RDC) clinical diagnosis of myofacial pain with or without disc displacement, arthralgia, arthritis, or arthosis
* Three or more significant systemic conditions, e.g. depression, fibromyalgia, GI or reproductive disturbances, upper respiratory problems, etc. in the preceding 2 years.

Exclusion criteria:

* Diagnosed organic or medication induced major mental illness (e.g., schizophrenia, bipolar)
* Other neurological diagnoses (epilepsy, Parkinsons)
* Pregnancy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Portland
country: United States
facility: Center for Health Research, Northwest
state: Oregon
Study officials:
affiliation: Center for Health Research, Northwest
name: Nancy Vuckovic, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06718374: Chest Pain Symptoms Differences Between Diabetic Patients and Non
Official title: Chest Pain Symptoms Differences Between Diabetes Mellitus and Non-diabetes Mellitus Patients with Acute Coronary Syndrome
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Chest Pain
Diabetes Mellitus
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2024-12-05
Enrollment: 50
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All cases admitted to ED who meet the eligibility criteria will be recruited in this study after obtaining an informed consent chest pain of DM and non-DM patients with the acute coronary syndrome

Brief summary: Cardiovascular disease is the most severe cause of death among all non-infectious diseases and accountable for 17.5 million deaths in the world. Heart mortality in patients with DM is frequently associated with prevalence silent ischemia, which is triggered by autonomic neuropathy, thereby decreasing the chest pain felt by them


Eligibility criteria: Inclusion Criteria:

i) Patients diagnosed with STEMI and NSTEMI ii) Both genders iii) above the age of 30 years iv) Patients with acute myocardial infarction with or without chest pain (angina) for 24 hours v) patients who are hemodynamically stable vi) patients without acute decompensated heart failure (ADHF) vii) patients without malignant arrhythmias viii) patients without in Acute Lung Oedem (ALO) condition ix) patients not using ventilator x) patient willing to and become respondents.

Exclusion Criteria:

i) Patients with several complications, thereby making it impossible to interview them ii) patients who have never undergone CABG surgery iii) patients who refuse to be respondents

Primary outcomes:
measure: Hospital admission
timeFrame: 1 day
measure: Intensive Care Unit admission
timeFrame: One week
measure: Mortality
timeFrame: One month
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut university
Study officials:
affiliation: Assiut University
name: Essam El-dien M Abdullah, MD
role: STUDY_DIRECTOR
affiliation: Ismailia Universiry
name: Zeinab Abd-Elatiff, MD
role: STUDY_DIRECTOR
affiliation: Assiut University
name: Khalid Abdelbaky, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01185574: Vitamin D for Improving Metabolic Control and Depressive Symptoms
Official title: Vitamin D for Improving Metabolic Control and Depressive Symptoms in Women With Diabetes; The Sunshine Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Depressive Symptoms
Diabetes
Lead sponsor: Loyola University
Sponsor class: OTHER
First posted: 2010-08-20
Enrollment: 50
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study will examine whether weekly vitamin D supplementation in women with significant depressive symptoms and diabetes will exhibit improved mood and metabolic control. If supplementation with Vitamin D is beneficial, it will be a simple and cost-effective method for treatment. Women will be targeted since they have greater depression and worse metabolic control than men with diabetes.


Eligibility criteria: Inclusion Criteria:

1. Women aged 18 and older
2. medically stable type 2 diabetes with HBA1c \<9%.
3. significantly elevated depressive symptoms as measured by a score greater than or equal to 14 using the Center for Epidemiologic Studies Depression Tool (CES-D.

Exclusion Criteria:

1. vitamin D levels of 32 ng/dl or greater
2. malabsorption problems (e.g., crohn's disease, celiac sprue)
3. hypercalcemia-level greater than 10.5 mg/dl
4. Severe complications of diabetes (amputation, blindness, or renal problems) 5) Women with low thyroid function

6) active suicidal ideation, a history of bipolar depression, psychotic disorders, and current alcohol or substance disorders. Active treatment for depression (e.g., antidepressant therapy) will not be exclusion criteria 7) Any serious chronic illness that may impact on their health-related quality of life and treatment effect 8) Women who are pregnant 9) Women who have had bariatric surgery.

Primary outcomes:
measure: Metabolic control
timeFrame: 6 months
Secondary outcomes:
measure: depressive symptoms
timeFrame: 6 months
Other outcomes:
Locations:
city: Maywood
country: United States
facility: Loyola University Medical Center
state: Illinois
Study officials:
References:
Clinical trial NCT02956174: Posterior CAD/CAM Cobalt-chromium Alloy Single Crowns: 4-year Prospective Clinical Study
Official title: Posterior CAD/CAM Cobalt-chromium Alloy Single Crowns: 4-year Prospective Clinical Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Single Tooth Lost
Lead sponsor: Federico II University
Sponsor class: OTHER
First posted: 2016-11-06
Enrollment: 89
Sex: ALL
Minimum age (years): 21
Maximum age (years): 68
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Objectives - To evaluate the 4-year clinical outcomes of ceramic veneered Computer Aided Design/Computer Aided Manufacturing (CAD/CAM) Co-Cr single crowns supported by natural teeth in posterior regions.

Material and methods - Eighty-nine patients were provided with 120 ceramic veneered CAD/CAM Co-Cr single crowns replacing either premolars and molars. Specific inclusion criteria were needed and tooth preparations were standardized and performed by 2 expert prosthodontists. CAD/CAM Co-Cr frameworks were fabricated and veneered with ceramics. The restorations were cemented using a eugenol-free zinc oxide luting agent. The patients were recalled after 1, 6, 12, 24, 36 and 48 months. The survival and success of the restorations were evaluated. The technical and esthetic outcomes were examined using the United States Public Health Service criteria. The biologic outcomes were analyzed at abutment and contralateral teeth and descriptive statistics were performed.


Eligibility criteria: Inclusion criteria:

* good general health
* American Society of Anesthesiologists (ASA) ASA I or ASA II condition; periodontal health
* Angle class I occlusal relationship
* minimum of 10 couples of opponent teeth
* good oral hygiene
* no evident signs of parafunctions and/or temporomandibular disorders.
* periodontal health of abutment teeth (absence of tooth mobility, absence of furcation involvement);
* proper positioning of abutment teeth in the dental arch (tooth axis adequate for a SC)
* sufficient occlusal-cervical height of the clinical crown of abutment teeth (≥ 4 mm) for the retention of a SC
* vital or endodontically treated to a clinically sound state abutment teeth;
* abutment teeth opposing natural teeth.

Exclusion criteria:

* high caries activity
* presence of periodontal disease on the abutment tooth
* occlusal-cervical height of the abutment tooth \< 4 mm
* reduced interocclusal distance or supraerupted opposing teeth
* unfavorable crown-to-root ratio
* severe were facets, clenching and/or bruxism
* presence of removable partial dentures (RPDs)
* pregnancy or lactation
* alcohol and/or drug addiction

Primary outcomes:
measure: Survival percentage
timeFrame: 4 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: