Clinical trial NCT03356340: The Singapore Chinese Health Study
Official title: The Singapore Chinese Health Study
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Cancer
End Stage Renal Disease
Diabetes
Cardiovascular Diseases
Lead sponsor: Duke-NUS Graduate Medical School
Sponsor class: OTHER
Collaborators: name: National University of Singapore
First posted: 2017-11-29
Enrollment: 63257
Sex: ALL
Minimum age (years): 45
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study was established between April 1993 and December 1998 through the recruitment of a residential cohort of 63,257 Chinese men (n=27,959) and women (n=35,298), who were aged 45-74 years, and residing in public housing estates.

Brief summary: The "Singapore Chinese Health Study" is a cohort study established by the Department of Epidemiology and Public Health in National University of Singapore, together with collaborators from several universities in the United States of America. This is a long-term study to help doctors and scientists understand the influence of diet, lifestyle and environment on the development of common diseases among Singaporean men and women. This includes cancer, heart disease, stroke, dementia, osteoporosis, high cholesterol and diabetes. The aim is to help us understand the causes of these diseases and to discover effective and efficient approaches for prevention and treatment.

Detailed description: The cohort consists of more than 60,000 men and women who were enrolled in the Singapore Chinese Health Study during 1993-1998. At the time of enrollment, participants were interviewed in-person regarding their dietary habits and other lifestyle factors. About half of them also donated small amounts of blood and urine for research between 2000 and 2004.

Eligibility criteria: Inclusion Criteria:

* Housing estate residents, ages 45-74 years, Chinese

Exclusion Criteria:

* None

Primary outcomes:
measure: Cancer incidence
timeFrame: 1993 to 2025
measure: End-stage Renal Disease
timeFrame: 1993 to 2025
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Seah JYH, Ong CN, Koh WP, Yuan JM, van Dam RM. A Dietary Pattern Derived from Reduced Rank Regression and Fatty Acid Biomarkers Is Associated with Lower Risk of Type 2 Diabetes and Coronary Artery Disease in Chinese Adults. J Nutr. 2019 Nov 1;149(11):2001-2010. doi: 10.1093/jn/nxz164.
citation: Seah JYH, Koh WP, Yuan JM, van Dam RM. Rice intake and risk of type 2 diabetes: the Singapore Chinese Health Study. Eur J Nutr. 2019 Dec;58(8):3349-3360. doi: 10.1007/s00394-018-1879-7. Epub 2018 Dec 10.
citation: Lew QJ, Jafar TH, Jin A, Yuan JM, Koh WP. Consumption of Coffee but Not of Other Caffeine-Containing Beverages Reduces the Risk of End-Stage Renal Disease in the Singapore Chinese Health Study. J Nutr. 2018 Aug 1;148(8):1315-1322. doi: 10.1093/jn/nxy075.
citation: Neelakantan N, Koh WP, Yuan JM, van Dam RM. Diet-Quality Indexes Are Associated with a Lower Risk of Cardiovascular, Respiratory, and All-Cause Mortality among Chinese Adults. J Nutr. 2018 Aug 1;148(8):1323-1332. doi: 10.1093/jn/nxy094.