louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04589780: Is There a Relationship Between the Risk of Injury and Posture in Wrestlers?
Official title: Is There a Relationship Between the Risk of Injury and Posture in Wrestlers?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sport Injury
Posture
Wrestling
Risk Reduction
Keywords: Wrestling
Functional movement screen
Injury risk
Posture
Lead sponsor: Ankara Yildirim Beyazıt University
Sponsor class: OTHER
First posted: 2020-10-19
Enrollment: 68
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: In this cross-sectional study, 18- to 40-year-old elite wrestler who have won medals in their championships from four different clubs will be tested

Brief summary: This study was planned to investigate the relationship between the risk of injury and posture in wrestlers. The study will be included male wrestlers. The spine posture and flexibility of the athletes will be measured during standing position with the Idiag M360® brand Spinal Mouse (SM), while the overall body posture will be measured from the anterior and lateral sides using the New York Posture Analysis Method (NYPAM). Injury risks of the athletes will be evaluated by Functional Movement Screen (FMS) which was consisting of seven basic movement patterns.


Eligibility criteria: Inclusion Criteria:

* Being between the ages of 18 and 40
* To be a professional wrestler who won medals in the Turkey championships

Exclusion Criteria:

* had injury for in the last 6 months
* had a history of surgery, or chronic and progressive disease
* had any orthopaedic or neurological problems

Primary outcomes:
measure: Posture Assessment
timeFrame: 2 weeks
measure: Sagittal spinal alignment and mobility
timeFrame: 2 weeks
measure: Injury risk assessment
timeFrame: 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara Yıldırım Beyazıt University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation
state: Etlik
Study officials:
References:
Clinical trial NCT04601480: PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Current Opioid-User Population
Official title: PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Current Opioid-User Population
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Opioid-use Disorder
Opioid Use
Opioid Abuse
Lead sponsor: University of Minnesota
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
First posted: 2020-10-23
Enrollment: 309
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 43 Primary Care Clinics will be randomized to be in one of 4 arms: 1) Care as usual, 2) Choice architecture nudge, 3) Prescription Drug Monitoring Program (PMP) Integration \& nudge, 4) Choice architecture nudge + PMP Integration \& nudge
Primary purpose: PREVENTION

Brief summary: The objective of this research is to assess the effects of electronic health record (EHR)-based decision support tools on primary care provider (PCP) decision-making around pain treatment and opioid prescribing. The decision support tools are informed by principles of "behavioral economics," whereby clinicians are "nudged," though never forced, towards guideline-concordant care.

Detailed description: To test the effects of these decision support tools for improving the quality of care for pain treatment, the investigators will implement a pragmatic clinic-randomized trial across the primary care clinics of Fairview Medical Group and University of Minnesota Physicians.

The study has two parallel components. The decision support tools to be tested will differ somewhat depending on whether a given patient is opioid-naïve, or whether a given patient is a current opioid-user. Four sets of analyses will be conducted separately: one for the opioid-naïve group using EHR data, one for the current opioid-user group using EHR data, one at the PCP-level using web survey data, and one at the PCP-level using MN Prescription Drug Monitoring Program (PDMP) data.

Eligibility criteria: Inclusion Criteria:

- All primary care providers from all of the Fairview and University of Minnesota Physicians study clinics

Exclusion Criteria:

- Primary care providers who work less than 20% full time equivalent (FTE)

Primary outcomes:
measure: Opioid Tapering Rate, Category 1
timeFrame: 12 months
measure: Opioid Tapering Rate, Category 2
timeFrame: 12 months
measure: Opioid Tapering Rate, Category 3
timeFrame: 12 months
Secondary outcomes:
measure: Prescription Reduction vs Discontinuation Rate
timeFrame: 12 months
Other outcomes:
measure: Prescription Increase Rate
timeFrame: 12 months
Locations:
city: Minneapolis
country: United States
facility: University of Minnesota
state: Minnesota
Study officials:
affiliation: University of Minnesota
name: Ezra Golberstein, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00388180: An Exploratory Study To Look At The Effect Of Two Investigational Drugs On Body Fat And Inflammation
Official title: A Randomized, Double-blind, Parallel Group Study to Evaluate the Effect of 12-week Treatment With GW590735X (20ug) or GW501516X (10mg) Relative to Placebo on Measures of Adiposity and Inflammation in Overweight and Obese Subjects
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hypercholesterolemia
Dyslipidaemias
Obesity
Keywords: cholesterol
inflammation
fat
Lead sponsor: GlaxoSmithKline
Sponsor class: INDUSTRY
First posted: 2006-10-16
Enrollment: 71
Sex: MALE
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes

Brief summary: The investigational drugs administered in this study activate proteins called PPARs. Data in the scientific literature on PPARs, as well as animal data and early clinical data generated by GSK with these drugs, suggest that activation of PPARs may cause the body to increase its use of fatty acids for energy, and lead to a reduction in body fat. There are also data to suggest a role for PPARs in regulating lipid (e.g., cholesterol) levels and inflammation. These and other activities of PPARs are being further explored in this clinical study.


Eligibility criteria: Inclusion criteria:

* Body Mass Index in the range of 27 - 43 kg/m2
* Waist circumference \> 95cm

Exclusion criteria:

* Clinically relevant abnormalities on screening ECG/holter, labs or medical examination
* Use of tobacco within 6 months of the study
* Regular strenuous exercise
* Use of prescription or non-prescription medications, including vitamins and herbal/dietary supplements
* LDL \< 80mg/dL; TG \<100mg/dL or \>400mg/dL

Primary outcomes:
measure: Body fat levels
Secondary outcomes:
measure: Levels of multiple proteins/biomarkers in blood and fat tissue, as well as specific lipid in muscle and liver (via imaging). Gene expression in blood and fat tissue.
Other outcomes:
Locations:
city: Baton Rouge
country: United States
facility: GSK Investigational Site
state: Louisiana
Study officials:
affiliation: GlaxoSmithKline
name: GSK Clinical Trials
role: STUDY_DIRECTOR
References:
citation: Olson EJ, Pearce GL, Jones NP, Sprecher DL. Lipid effects of peroxisome proliferator-activated receptor-delta agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2289-94. doi: 10.1161/ATVBAHA.112.247890. Epub 2012 Jul 19.
Clinical trial NCT03379480: Study on Examination of Therapeutic Efficacy and Potential Mechanisms of Yoga Treatment in Schizophrenia
Official title: Examination of Therapeutic Efficacy and Potential Mechanisms of Yoga Treatment in Schizophrenia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Schizophrenia
Keywords: Schizophrenia
Yoga
fMRI
Lead sponsor: National Institute of Mental Health and Neuro Sciences, India
Sponsor class: OTHER
Collaborators: name: SCARF (Schizophrenia Research Foundation ,India) Schizophrenia
First posted: 2017-12-20
Enrollment: 96
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to examine whether yoga is efficacious as an add-on treatment for negative symptoms of schizophrenia in a randomized multi-centric trial and also to examine functional brain changes associated with self-reflection after treatment with yoga.


Eligibility criteria: Inclusion Criteria:

Schizophrenia Subject

1. ICD (International Classification of Diseases) 10 diagnosis of schizophrenia
2. capacity to provide informed consent, as evaluated by the MacArthur Competence Assessment Tool for Clinical Research
3. no other current comorbid axis I diagnosis (except nicotine abuse/dependence) and no general impaired intellectual functioning

Healthy volunteers:

1. Males and females between 18 and 45 years
2. Capacity to provide informed consent
3. absence of past or present psychiatric illnesses including substance abuse 4) no general impaired intellectual functioning (MMSE above24)

Exclusion Criteria:

1. Other current comorbid axis I diagnosis (except nicotine abuse/dependence) and general impaired intellectual functioning
2. History of alcohol or substance abuse or dependence in the last 12 months (with the exception of nicotine)
3. Any Contraindication to MRI like metal implants or paramagnetic objects within the body or claustrophobia (only for patients undergoing fMRI at NIMHANS)
4. Past history of head injury resulting in loss of consciousness or neurosurgery
5. Concomitant severe medical conditions
6. Change in dose of antipsychotic medication or Electroconvulsive therapy in the past 6weeks
7. Pregnant or lactating -

Primary outcomes:
measure: Improvement in negative symptoms in patients with schizophrenia
timeFrame: At the end of 12 weeks of yoga
Secondary outcomes:
measure: fMRI changes
timeFrame: At the end of 12weeks
Other outcomes:
Locations:
city: Bangalore
country: India
facility: National Institute of Mental Health and Neurosciences
state: Karnataka
Study officials:
affiliation: National Institute of Mental Health and Neuro Sciences, India
name: Naren P Rao, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00198640: AMR of Streptococcus Pneumoniae Carriage Strains
Official title: Antimicrobial Resistance of Streptococcus Pneumoniae Carriage Strains Among Bangladeshi Neonates: Epidemiology, Determinants and Risk Factors
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Infection
Keywords: animal antibiotics
human antibiotics
Lead sponsor: Johns Hopkins Bloomberg School of Public Health
Sponsor class: OTHER
First posted: 2005-09-20
Sex: ALL
Minimum age (years): 0
Standard ages: CHILD
ADULT
OLDER_ADULT
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: ECT

Brief summary: This study looks at the usage of human antibiotics for treatment of animals in Bangladesh.


Eligibility criteria: Inclusion Criteria:

* Bangladesh location

Exclusion Criteria:

* none

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Johns Hopkins Bloomberg School of Public Health
name: Mathuram Santosham, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00527644: Clinical Evaluation of Spring-Type Laparoscopic Clip Technology
Official title: Clinical Evaluation of Spring-Type Laparoscopic Clip Technology
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Healthy
Keywords: biliary leaks after laparoscopic cholecystectomy
Lead sponsor: University of Missouri-Columbia
Sponsor class: OTHER
First posted: 2007-09-11
Enrollment: 14
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The Visu-Loc spring clip is being used to occlude the cystic duct at the time of laparoscopic cholecystectomy. A hepato-iminodiacetic acid (HIDA) scan will be completed on post operative day one to check for biliary leaks.

Detailed description: The purpose of this study is to evaluate how effective the Visu-Lock clip is at preventing leakage of bile (liquid made by liver and stored in gall bladder) after gallbladder surgery. It is not known if the Visu-Lock clip stops leaks better than other clips that have been used during gallbladder surgery.

Null hypothesis: There is no difference in subclinical or clinical leak rate between spring and crush clips used for cystic duct ligation.

Alternative hypothesis: Titanium spring clips decrease the rate of subclinical or clinical biliary leak from the cystic duct stump after laparoscopic cholecystectomy.

Eligibility criteria: Inclusion Criteria:

* Adult(18 or older)
* Diagnosis of cholelithiasis or cholecystitis
* Diagnosis of choledocholithiasis or biliary dyskinesia
* scheduled fo laparoscopic cholecystectomy
* Females: NOT pregnant

Exclusion Criteria:

* Breastfeeding
* Malignancy
* Inflammatory bowel disease (IBD)
* Ulcerative colitis (UC)
* Receiving steroids
* Severe chronic obstructive pulmonary disease (COPD) or pulmonary disorder
* History of connective tissue disorder

Primary outcomes:
measure: No Leak, Subclinical Leak or Clinical Bile Leak on Post-operative Hepato-iminodiacetic Acid (HIDA) Scan.
timeFrame: By post op day one HIDA scan.
Secondary outcomes:
measure: Any Other Evidence of Biliary Leak. Surgeon Assessments of Device Use: Ease of Use , Deployment and Clip Security.
timeFrame: By post op day one HIDA scan.
Other outcomes:
Locations:
city: Columbia
country: United States
facility: University of Missouri Hospital and Clinics
state: Missouri
Study officials:
affiliation: Chief, Division of General Surgery
name: Bruce Ramshaw, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01492244: Validation of an Online Knee Pain Map and Questionnaire: A Probabilistic Diagnostic Tool
Official title: Alidation of an Online Knee Pain Map and Questionnaire: A Probabilistic Diagnostic Tool
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Knee Pain
Keywords: Knee pain
map
questionnaire
survey
Lead sponsor: University of California, Los Angeles
Sponsor class: OTHER
First posted: 2011-12-14
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients older than 18 years old with knee pain that contains a known diagnosis for their pain.

Brief summary: "Blank" has designed a medical diagnostic system in the form of an unvalidated online questionnaire and drawing tool used to describe and identify the location of knee pain, respectively. A component of the survey includes the patient inputting their diagnosis as the etiology of their knee pain. Dr. Ivo Dinov's team has used the data from 100,000 patient surveys to construct a probabilistic model to diagnose those who fill out the questionnaire and knee pain map but do not have a diagnosis. However, the validity of the online survey and the accuracy of the probabilistic model has not been confirmed in patients with known diagnoses. Therefore, the purpose of this study will be to recruit patients with knee pain at UCLA orthopedic clinics to complete the online survey which will then be applied to the probabilistic model to output possible diagnoses. The results will be compared to the actual diagnosis assigned to that patient in the clinic. If validated, the online survey may serve as a tool for diagnostic and research purposes.


Eligibility criteria: Inclusion Criteria:

* patients with knee pain and a known diagnosis for their pain
* patients older than 18 years old

Exclusion Criteria:

* patients that are unable or unwilling to complete the online survey.
* patients who do not have a diagnosis for their knee pain

Primary outcomes:
measure: The ability of the UCLA modeling software to predict diagnosis based on questionnaire answers
timeFrame: One year
Secondary outcomes:
measure: Accuracy of patient input diagnosis compared to orthopedic surgeon diagnosis
timeFrame: One Year
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: UCLA
state: California
Study officials:
References:
Clinical trial NCT02770144: The Impact of Family Financial Support on Child Health
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Child Overall Health Related Quality of Life
Keywords: Child Quality of Life
Financial Coaching
Socioeconomic Status
Social Determinants of Health
Lead sponsor: University of California, Los Angeles
Sponsor class: OTHER
First posted: 2016-05-12
Enrollment: 150
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The investigators have partnered with financial coaching organizations to establish what the investigators have termed a "Medical-Financial Partnership (MFP)" that offers financial coaching to improve financial and mental health.The investigators will evaluate the MFP's impact on child overall health rating.

Detailed description: Financial coaching is a new tool in the field of community development, but it has already demonstrated significant financial impact in a number of studies, including one randomized trial conducted by the Urban Institute. Financial coaching improves participant financial literacy, budgeting, saving for financial emergencies, and debt level. The investigators' project will help clinicians and the field of community economic development understand health and well-being through a new economic lens and assess the health-related impacts of the emerging field of financial coaching. The investigators have partnered with financial coaching organizations to establish what they have termed a "Medical-Financial Partnership (MFP)" that offers financial coaching to improve financial and mental health. The investigators will evaluate the MFP's impact on parent-rated child overall health on a 5 point likert scale (Excellent to Poor).

Community-based participants will be recruited from South Los Angeles and randomized to receive either monthly financial coaching plus access to referral for social services (intervention) or access to referral for social services alone (control). Inclusion criteria include having dependents under age 18, having some form of income, and having a tax identification number (social security number or Individual Tax Identification Number). Participants will be surveyed quarterly regarding their parent-rated child overall health on a 5 point likert scale (Excellent to Poor).

Eligibility criteria: Inclusion Criteria:

* Participants will include caregivers and parents with one or more dependent children, some form of income, and a tax identification number.

Exclusion Criteria:

* Inability to take part in financial coaching or primary language other than English or Spanish.

Primary outcomes:
measure: Parent-Rated Child Overall Health
timeFrame: Up to One Year
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: LIFT-LA
state: California
Study officials:
affiliation: University of California, Los Angeles
name: Adam Schickedanz, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06271044: a. Reducing Radioiodine Treatment in Papillary Thyroid Cancer. RAILESS
Official title: Reducing Radioiodine Treatment in Low Risk Papillary Thyroid Cancer
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: to Omit Radioiodine Treatment Safely in Patients With Low -Risk Papillary Thyroid Cancer With Seize of 11-20mm
Keywords: radioiodine treatment, low risk thyroid cancer, papillary thyroid cancer
Lead sponsor: Helsinki University Central Hospital
Sponsor class: OTHER
First posted: 2024-02-21
Enrollment: 61
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Patients with low risk papillary thyroid cancer either received a radioiodine treatment according to the normal Finnish treatment schedule or were schedulded for only follow-up .
Primary purpose: OTHER

Brief summary: To study if its is safe to reduce the amount of postoperative treatments in those patients, who have been operated on because of a low-risk intrathyroidal papillary thyroid cancer with diameter of 11-20mm, and in whom postoperative thyroglobulin levels are of low level.

Detailed description: The purpose of the study : to enroll about 50 patients operated on because of a low-risk intrathyroidal papillary thyroid cancer with diameter of 11-20mm, and in whom postoperative thyroglobulin levels are of low level.

Methods: either to follow-up patients according to the study protocol without radioiodine treatment or to give a radioiodine treatment with a dose of 1.1 GBq according to the normal Finnish treatment protocol for papillary thyroid cancer to those patients who themselves preferred to have a normal postoperative treatment.

Eligibility criteria: Inclusion Criteria:

* low risk papillary intrathyroidal thyroid cancer with diameter of 11-20mm
* no lymphnode metastases

Exclusion Criteria:

* high risk papillary cancer
* mutlifocal papillary cancer

Primary outcomes:
measure: Event free situation during follow-up event free /disease free
timeFrame: 10 yrs
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Medical Oncologist
name: Päivi Halonen, MD
role: PRINCIPAL_INVESTIGATOR
References: