Clinical trial NCT05869526: A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults
Official title: A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults: a Randomised Controlled Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sarcopenia
Keywords: muscle mass
strength
omega-3
ageing
Lead sponsor: University of Glasgow
Sponsor class: OTHER
First posted: 2023-05-22
Enrollment: 61
Sex: ALL
Minimum age (years): 60
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 1:1:1 basis
Primary purpose: PREVENTION

Brief summary: The aim of the study is to compare the effects of Krill Oil and Fish Oil supplementation on muscle function in older adults. The secondary aim is to investigate the mechanisms underlying the beneficial effects previously observed.


Eligibility criteria: Inclusion Criteria:

* Older adults (aged 60 years or older). BMI less than 30kg/m2

Exclusion Criteria:

* Participants (diagnosed and being treated for a pre-existing medical condition (cancer, kidney disease, liver disease, diabetes mellitus and cardiovascular disease, uncontrolled hypertension, gait disturbances limiting the ability to perform assessments of muscle function, dementia, affecting muscles known to use drugs (e.g., steroids). History of allergy to fish or fish oil and regular consumption of more than1portion of oily fish per week or use of fish oil or krill oil supplements will also be excluded.

Primary outcomes:
measure: Change in knee extensor maximal isometric torque ( MVC)
timeFrame: Change from baseline to 16 weeks
Secondary outcomes:
measure: Change in fat mass
timeFrame: Change from baseline to 16 weeks
measure: Change in lean mass
timeFrame: Change from baseline to 16 weeks
measure: Blood sample
timeFrame: Change from baseline to 16 weeks
measure: Change in Grip strength
timeFrame: Change from baseline to 16 weeks
measure: Change in Muscle thickness
timeFrame: Change from baseline to 16 weeks
measure: Force steadiness during submaximal isometric knee extensor contractions
timeFrame: Change from baseline to 16 weeks
measure: Neuromuscular Junction (NMJ)
timeFrame: Change from baseline to 16 weeks
measure: Change in gait speed
timeFrame: Change from baseline to 16 weeks
measure: Change in Chair rise time
timeFrame: Change from baseline to 16 weeks
Other outcomes:
measure: Step Time (Sec)
timeFrame: Change from baseline to 16 weeks
measure: Cycle Time (Sec)
timeFrame: Change from baseline to 16 weeks
measure: Step Length (CM)
timeFrame: Change from baseline to 16 weeks
measure: Stride Length (CM)
timeFrame: Change from baseline to 16 weeks
measure: H-H Base Support (CM)
timeFrame: Change from baseline to 16 weeks
measure: Single Support (%GC)
timeFrame: Change from baseline to 16 weeks
measure: Double Support (%GC)
timeFrame: Change from baseline to 16 weeks
measure: Swing (%GC)
timeFrame: Change from baseline to 16 weeks
measure: Stance (%GC)
timeFrame: Change from baseline to 16 weeks
measure: Step/ Extremity Ratio
timeFrame: Change from baseline to 16 weeks
measure: Toe In/ Out (deg)
timeFrame: Change from baseline to 16 weeks
measure: Distance (CM)
timeFrame: Change from baseline to 16 weeks
measure: Ambulation Time (Sec)
timeFrame: Change from baseline to 16 weeks
measure: Velocity (CM/Sec)
timeFrame: Change from baseline to 16 weeks
measure: Mean Normalized Velocity
timeFrame: Change from baseline to 16 weeks
measure: Number of Steps
timeFrame: Change from baseline to 16 weeks
measure: Cadence (Steps/Min)
timeFrame: Change from baseline to 16 weeks
measure: Step Time Differential (Sec)
timeFrame: Change from baseline to 16 weeks
measure: Step Length Differential (CM)
timeFrame: Change from baseline to 16 weeks
measure: Cycle Time Differential (Sec)
timeFrame: Change from baseline to 16 weeks
Locations:
city: Glasgow
country: United Kingdom
facility: Stuart Robert Gray
state: Scotland
Study officials:
References: