Clinical trial NCT05073874: Attentional Focus and Prefrontal Cortical Activation in Older Adults and Patients With Parkinson's Disease (PD)
Official title: Effects of Different Attentional Focus During Walking on Prefrontal Cortical Activation in Older Adults and Patients With Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Parkinson Disease
Keywords: Attention
NIRS
Gait
Prefrontal cortex
Parkinson's disease
Lead sponsor: Centre Hospitalier Régional d'Orléans
Sponsor class: OTHER
First posted: 2021-10-12
Enrollment: 45
Sex: ALL
Minimum age (years): 60
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Attention may influence the motor performance and frontal activity. This study will examine the effect of different attentional focus: internal, external and divided attention (dual task) on prefrontal cortical activation (fNIRS) and on gait performance. Thirty older adults and thirty PD will participate in this study.

Detailed description: The subjects will be guided to walk at a normal pace while maintaining the required attentional focus. Subjects will walk on 20 m four times in each of the four different focus conditions :

1. no instructions about the attentional focus
2. internal focus on their feet movements,
3. external focus on two lines drawn on the floor,
4. divided attention (walking while performing an arithmetic task).

A fNIRS system will be used for the prefrontal cortex activation evaluation and FeetMe soles for gait analyses.

Eligibility criteria: Inclusion Criteria:

* For 2 groups :

  * Man or woman 60-85 years old
  * Informed consent obtained
* Group Parkinson : clinical diagnosis of idiopathic Parkinson's Disease, according to the UK Brain Bank criteria.

Exclusion Criteria:

* For 2 groups :

  * Assisted walker
  * Neurological (other than those resulting from Parkinson's disease), cardiologic, rheumatologic disorders
  * Disorders affecting gait.
  * Montreal Cognitive Assessment (MOCA) \< 24.
  * Concomitant medication likely to interfere with the results.
* Group Parkinson:

  * freezing
  * Hoehn et Yahr \> III

Primary outcomes:
measure: Effects of oxyhemoglobin variations on hemodynamic response in prefrontal cortex
timeFrame: Baseline
measure: Effects of deoxyhemoglobin variations on hemodynamic response in prefrontal cortex
timeFrame: Baseline
Secondary outcomes:
measure: Effects of speed on gait.
timeFrame: baseline
measure: Effects of cadence on gait.
timeFrame: baseline
measure: Effects of stride length on gait.
timeFrame: baseline
measure: Effects of double support time on gait.
timeFrame: baseline
Other outcomes:
Locations:
city: Orléans
country: France
facility: CHR Orléans
Study officials:
affiliation: CHR d'ORLEANS
name: Canan OZSANCAK, Dr
role: PRINCIPAL_INVESTIGATOR
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