Clinical trial NCT00673374: Correlation of Location of Abdominal Tenderness With Acute CT Abnormalities in Emergency Department Patients
Official title: Correlation of Location of Abdominal Tenderness With Acute CT Abnormalities in Emergency Department Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Abdominal Pain
Keywords: emergency
acute
nontraumatic
abdominal pain
tenderness
CT scan
radiation
diagnosis
Lead sponsor: Duke University
Sponsor class: OTHER
First posted: 2008-05-07
Enrollment: 102
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All consecutive emergency department patients undergoing abdominal CT for non-traumatic abdominal pain and tenderness will be prospectively enrolled, with the following exceptions. For study purposes, "abdominal pain and tenderness" is defined as pain and tenderness to direct palpation in the region anterior to the mid-axillary line bilaterally, and extending from the costal margins to the inguinal ligaments. Consequently, patients undergoing CT for indications such as isolated vomiting, fever without source, staging of malignancies, isolated flank pain or suspected renal colic, or other indications that do not meet the above definition will not be enrolled.

Brief summary: To determine the correlation between the region of abdominal tenderness determined by the examining physician and the location of acute pathology diagnosed on abdominal CT. We hypothesize that the acute pathology diagnosed by CT will lie within the region marked on the abdominal wall by the examining physician prior to CT.


Eligibility criteria: Inclusion Criteria:

* All consecutive emergency department patients undergoing abdominal CT for non-traumatic abdominal pain and tenderness will be prospectively enrolled, with the following exceptions. For study purposes, "abdominal pain and tenderness" is defined as pain and tenderness to direct palpation in the region anterior to the mid-axillary line bilaterally, and extending from the costal margins to the inguinal ligaments. Consequently, patients undergoing CT for indications such as isolated vomiting, fever without source, staging of malignancies, isolated flank pain or suspected renal colic, or other indications that do not meet the above definition will not be enrolled.

Exclusion Criteria:

* Pregnant women do not routinely undergo abdominal CT due to radiation concerns and will be excluded from the study.
* Patients with altered mental status or altered abdominal sensation (due to neurological conditions such as paraplegia) that may prevent assessment of the location of abdominal tenderness will be excluded.
* Preverbal children will be excluded as they rarely undergo CT and will be unable to indicate the region of maximal tenderness.

Primary outcomes:
measure: sensitivity and specificity of a hypothetical limited CT restricted to the region of abdominal tenderness for detection of acute pathology on CT on the entire abdomen.
timeFrame: immediate
Secondary outcomes:
measure: the percentage decrease in radiation exposure which could be achieved by performing a CT restricted to the region of abdominal tenderness, compared with CT of the entire abdomen
timeFrame: immediate
Other outcomes:
Locations:
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
Study officials:
affiliation: Duke Health
name: Joshua S Broder, MD
role: PRINCIPAL_INVESTIGATOR
References: