louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02236767: Transcranial Magnetic Stimulation Treatment of Hoarding Disorder
Official title: Transcranial Magnetic Stimulation Treatment of Hoarding Disorder
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hoarding
Lead sponsor: Hartford Hospital
Sponsor class: OTHER
Collaborators: name: Neuronetics
First posted: 2014-09-11
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is multiple baseline study including up to three participants with a primary diagnosis of hoarding disorder. All patients will receive unblinded repetitive transcranial magnetic stimulation study intervention.

Detailed description: Study assessments will be conducted at pre-baseline, weekly during baseline assessment (until a stable baseline is established, but not less than 2, 4, and 6 weeks for patients respectively), weekly during treatment, and at post-treatment. Magnetic resonance imaging (MRI) will be competed at pre-baseline, pre-treatment, and post-treatment. Treatment will entail daily (5 days/week) sessions of repetitive transcranial magnetic stimulation using the Neurostar Therapy System for 6 weeks employing right-sided, low frequency stimulation (1 Hz, 900 pulses/session for 30 sessions, 27,000 total pulses, intensity at 90% of the passive motor threshold) to the dorsolateral prefrontal cortex (DLPFC). Neuronavigation will direct coil placement over the DLPFC based upon structural MRI.

Eligibility criteria: Inclusion Criteria:

* Diagnosed with hoarding disorder as primary disorder
* Clinical Global Impression Score \> 3
* Saving Inventory-Revised score \> 39

Exclusion Criteria:

* Any contraindication for participation in magnetic resonance imaging or transcranial magnetic stimulation
* Severe and/or unstable medical or psychiatric condition that require immediate medical attention
* Diagnosed with current major depressive episode
* Currently taking psychiatric medication

Primary outcomes:
measure: The Saving Inventory-Revised (SI-R) Total Score
timeFrame: Pre-baseline, Post-baseline/Pre-treatment, Post-treatment, 2-Month Follow-up
Secondary outcomes:
Other outcomes:
Locations:
city: Hartford
country: United States
facility: Hartford Hospital
state: Connecticut
Study officials:
affiliation: Hartford Hospital
name: Gretchen J Diefenbach, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Diefenbach GJ, Tolin DF, Hallion LS, Zertuche L, Rabany L, Goethe JW, Assaf M. A case study of clinical and neuroimaging outcomes following repetitive transcranial magnetic stimulation for hoarding disorder. Am J Psychiatry. 2015 Nov 1;172(11):1160-2. doi: 10.1176/appi.ajp.2015.15050602. No abstract available.
Clinical trial NCT06745167: Comparative Efficacy and Safety of Extensive Electro-Anatomical Guided Pulsed Field Ablation Versus Radiofrequency Ablation in Persistent Atrial Fibrillation
Official title: Comparative Efficacy and Safety of Electro-Anatomical Guided Pulsed Field Ablation Versus Radiofrequency Ablation in the Treatment of Persistent Atrial Fibrillation: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Atrial Fibrillation (AF)
Keywords: atrial fibrillation
pulsed field ablation
radiofrequency ablation
Lead sponsor: Shanghai Chest Hospital
Sponsor class: OTHER
Collaborators: name: Albert Einstein College of Medicine and Montefiore Medical Center
name: Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine
name: Shandong University of Traditional Chinese Medicine
name: Yuhuan Second People's Hospital
name: Changshu Hospital of Traditional Chinese Medicine
name: The PLA Navy Anqing Hospital
name: Jinan People's Hospital
name: Xuzhou Central Hospital
First posted: 2024-12-20
Enrollment: 600
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This multicenter, randomized controlled trial aims to compare the efficacy and safety of extensive electro-anatomical guided pulsed field ablation (EXT-PFA) with traditional radiofrequency ablation (RF) in treating persistent atrial fibrillation (PeAF). The trial seeks to determine if EXT-PFA, which integrates anatomical and electrogram-guided strategies, can provide superior outcomes in terms of safety and effectiveness compared to the standard RF ablation approach.


Eligibility criteria: Inclusion Criteria:

1.Adults aged 18-80 years diagnosed with persistent atrial fibrillation. 2.Ineffectiveness or intolerance to at least one Class I or III anti-arrhythmic drug.

Exclusion Criteria:

1. Major valvular diseases needing surgical intervention.
2. Presence of a left atrial thrombus on recent imaging.
3. Recent myocardial infarction or severe heart failure (LVEF ≤ 30%).
4. Current Severe Infection.

Primary outcomes:
measure: Freedom from Atrial Arrhythmia Recurrence at 12 Months
timeFrame: 12 months after ablation procedure
Secondary outcomes:
measure: Procedural Safety
timeFrame: From enrollment to completion of follow-up（at least 12 months）
measure: Symptom Relief (EHRA scores)
timeFrame: From enrollment to completion of follow-up（at least 12 months）
measure: Quality of Life (Short Form 36 Health Survey).
timeFrame: From enrollment to completion of follow-up（at least 12 months）
measure: Atrial Fibrillation Burden Reduction
timeFrame: From enrollment to completion of follow-up（at least 12 months）
Other outcomes:
Locations:
city: Shanghai
country: China
facility: No. 241, West Huaihai Road
state: Shanghai
Study officials:
affiliation: Shanghai Chest Hospital
name: Xu Liu
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05881967: Molecular Mechanism Study of Uterine Sarcoma
Official title: Molecular Mechanism Study of Uterine Sarcoma
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Uterine Sarcoma
Lead sponsor: Tongji Hospital
Sponsor class: OTHER
First posted: 2023-05-31
Enrollment: 300
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 400 patients who met the requirements includ 200 uterine sarcomas, 200 uterine leiomyomas.

Brief summary: The purpose of this project was to use multi-omics technology to screen the key factors for the occurrence and development of uterine sarcoma.

Detailed description: Uterine sarcomas are rare mesenchymal neoplasms in the female genital system, accounting for about 1% of female reproductive tract malignancies and 3%\~7% of uterine malignancies. Subtypes of uterine sarcoma are leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. Uterine leiomyosarcoma is the most common uterine sarcoma, accounting for about 1% to 2% of all uterine malignancies.

Uterine sarcomas differ in histologic appearance and clinical behavior. The incidence of uterine sarcoma is low and the prognosis is poor. Its manifestations mainly include abnormal vaginal bleeding, abdominal pain and abdominal mass, but none of these symptoms are specific.

For uterine sarcoma, there are no diagnostic serum markers and imaging features and the diagnosis of uterine sarcoma still mainly depends on postoperative pathological results. However, with the development of omics technology, immunophenotypes and molecular characterization of uterine sarcomas have increasingly been utilized to improve diagnostic classification and prognostication in uterine sarcomas. Uterine leiomyosarcoma, the most common subtype of uterine sarcoma, does not have a single defining molecular abnormality.

This project intends to use multi-omics technology to screen the key factors for the occurrence, development, and malignant transformation of uterine sarcoma, especially uterine leiomyosarcoma, and to map the interaction network of cell signaling pathways. It provides key molecular markers for the early assessment of recurrence and malignant transformation of uterine myoma after conservative treatment, and provides a molecular mechanism basis for finding solutions to prevent the progression and malignant transformation.

Eligibility criteria: Inclusion Criteria:

1. Age 18 or older;
2. Newly treated or recurenced uterine sarcoma.

Exclusion Criteria:

1. Diagnosis of other malignancies within the past 5 years;
2. history of pelvic or vaginal radiation therapy;
3. Known high-grade lesions of the cervix and endometrium.

Primary outcomes:
measure: Susceptible gene in women with uterine sarcoma
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Yan Li
state: Hubei
Study officials:
References:
Clinical trial NCT01625767: Tobacco Approach Avoidance Training for Adolescent Smokers-1
Official title: Tobacco Approach Avoidance Training for Smoking Cessation in Adolescent Smokers-Study 1
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Tobacco Use Disorder
Keywords: Nicotine
Smoking
Adolescent
Tobacco
Lead sponsor: Yale University
Sponsor class: OTHER
Collaborators: name: VU University of Amsterdam
First posted: 2012-06-21
Enrollment: 40
Sex: ALL
Minimum age (years): 13
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a two part study. Study 1 will compare Approach Avoidance Training (AAT) responses in smokers and nonsmokers in order to confirm that adolescent smokers experience cognitive bias towards tobacco-related stimuli.


Eligibility criteria: Inclusion Criteria:

* Between ages 13-18 years
* Able to read and write in English.
* Smokers: Smoking 5 or more cigarettes daily for at least 6 months; Baseline urine cotinine levels \> 500 ng/ml
* Nonsmokers: Never smokers; Baseline urine cotinine levels \< 50 ng/ml

Exclusion Criteria:

* Current criteria for dependence on another psychoactive substance
* Current diagnosis of psychosis, major depression or panic disorder
* Regular use of any psychoactive drugs including anxiolytics and antidepressants unless the medication has been taken consistently for 2 months, is currently being monitored by a physician, and the condition for which the medication is taken is considered to be stable
* Pregnant or lactating girls, based on self report.

Primary outcomes:
measure: automatic approach tendencies towards smoking-related stimuli
timeFrame: at end of AAT at Day 1
measure: automatic approach tendencies towards smoking-related stimuli
timeFrame: at end of AAT at Day 8
measure: automatic approach tendencies towards smoking-related stimuli
timeFrame: at end of AAT at Day 15
measure: automatic approach tendencies towards smoking-related stimuli
timeFrame: at end of AAT at Day 22
measure: automatic approach tendencies towards smoking-related stimuli
timeFrame: at end of AAT at Day 29
Secondary outcomes:
Other outcomes:
Locations:
city: New Haven
country: United States
facility: Yale University, School of Medicine, Dpeartment of Psychiatry
state: Connecticut
Study officials:
affiliation: Yale University
name: Suchitra Krishnan-Sarin, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00584467: Genetic and Inflammatory Markers in Cardiovascular Disease (GEM) Registry
Official title: Genetic and Inflammatory Markers in Cardiovascular Disease (GEM) Registry
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Atherosclerosis
Keywords: GEM
Arteriosclerosis
biomarkers
Atherosclerosis
Lead sponsor: University of California, Davis
Sponsor class: OTHER
Collaborators: name: University of California, San Francisco
First posted: 2008-01-02
Enrollment: 21
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects will mainly include individuals who are scheduled to undergo cardiac catheterization at UC Davis Medical Center, but may include other eligible individuals. Subjects may also include individuals who have objective evidence of the extent of arteriosclerosis of the coronary, femoral or carotid arteries.

Brief summary: This is an investigator initiated registry aimed at assembling a blood/serum and genomic resource (bank) of human blood samples with accompanying clinical data mainly from patients who are scheduled to undergo cardiac catheterization at UC Davis Medical Center, but may also include other eligible individuals. Funding is from institutional/divisional research funds.

Detailed description: This study is aimed at assembling a blood/serum and genomic resource (bank) of human samples with accompanying clinical data mainly from patients who are scheduled to undergo cardiac catheterization at UC Davis Medical Center, but may also include other eligible individuals. These samples will be analyzed at UC Davis Medical Center for determination of biomarker levels, and concomitantly analyzed at UC San Francisco in an IRB-approved protocol at that institution for genetic analysis (UCSF IRB approval # for this study is H711-15138-03; protocol name is "Discovery of Gene Mutations and Polymorphisms that Contribute to the Risk of Atherosclerosis"; principal investigator is John P. Kane, MD). All samples sent to UCSF will be de-identified and catalogued using an alphanumeric code. A number of candidate genes will be studied to detect mutations and polymorphisms that could contribute to the risk of atherosclerosis. The technique of hybridization sequencing will be employed for this. The techniques of classical statistical genetics will be employed for both cosegregation analysis and for the genome search approach. Clinical follow-up may be obtained at 6 and 12 months.

Eligibility criteria: Inclusion Criteria:

* Any individual cared for in the UC Davis Health System
* disorders of lipoproteins or arteriosclerosis

Exclusion Criteria:

* Subjects will be excluded only if they refuse to be in the study

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University of California, Davis
name: Jason Rogers, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06762067: Exercise Training on a Mirror for Intermittent Exotropia Control Post Strabismus Surgery
Official title: Exercise Training in Front of a Mirror for Intermittent Exotropia Control Post Strabismus Surgery: A Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Exercise Training
Intermittent Exotropia
Strabismus
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2025-01-07
Enrollment: 40
Sex: ALL
Minimum age (years): 5
Maximum age (years): 15
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study aims to explore the impact of mirror therapy on exodeviation control, near and far strabismus angles, and quality of life in intermittent exotropia control post strabismus surgery, as well as its effects on near and far strabismus angles.

Detailed description: Strabismus is a common childhood disorder causing eye deviation, affecting life quality and cosmetic appearance. Early detection and management improve binocular function and psychosocial problems. Intermittent exotropia is a common type. Surgery is the most common method for correcting strabismus, but complications can be difficult to treat. Physical therapy programs are limited in treating strabismus after surgery, and adding mirror therapy to traditional treatments may help maintain surgery results. This thesis aims to decrease this knowledge gap and improve the treatment of strabismus.

Eligibility criteria: Inclusion Criteria:

1. 40 boys and girls with ages from 5 to 15 years
2. History of strabismus surgery from 6 months presence of intermittent exotropia.
3. Normal sensory and motor fusion, equal visual acuity. Good general health condition.
4. Ability to understand and do the exercises at home

Exclusion Criteria:

1. systemic diseases as myasthenia gravis, multiple sclerosis and diabetes
2. Optic nerve injury, organic ocular disease, attention disorder and mental disorders
3. Attention disorder and learning disability

Primary outcomes:
measure: Assessment of change of the exodeviation control
timeFrame: at baseline and after 3 months
Secondary outcomes:
measure: Assessment of change of the near strabismus angles
timeFrame: at baseline and after 3 months
measure: Assessment of change of the far strabismus angles
timeFrame: at baseline and after 3 months
measure: Assessment of change of questions of Child and Proxy health related quality of life
timeFrame: at baseline and after 3 months
measure: Assessment of change of questions of health-related quality of life questionnaire for Parents of children with intermittent exotropia
timeFrame: at baseline and after 3 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03687567: A Retrospective Study on the Effect of HBA or HBB Genetic Defects on Early Embryonic Development
Official title: A Retrospective Study on the Effect of HBA or HBB Genetic Defects on Early Embryonic Development
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Thalassemia,Embryonic Development,Reproductive Sterility and Infertility
Lead sponsor: Reproductive & Genetic Hospital of CITIC-Xiangya
Sponsor class: OTHER
First posted: 2018-09-27
Enrollment: 737
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: One or both of infertility couples with thalassemia take PGD treatment.

Brief summary: Thalassemia is an anemia or pathological state caused by compounding absently or inadequately of one or more globin chains of hemoglobin due to the defects of the globin gene,and the carrying rate is high in southern China. Although there are many studies of Thalassemia, the relationship between the globin gene defects and the early embryo development has not been reported.

This study intends to carry out a retrospective analysis on the embryonic development of the patients with thalassemia assisted by PGD from January 1, 2011 to now in our hospital, to explore whether the HBA or HBB gene defects have a certain influence on the early embryo development, so as to accumulate certain data for reproductive health research.


Eligibility criteria: Inclusion Criteria:

* infertility couples with thalassemia(one or both )
* infertility couples treat by PGD

Exclusion Criteria:

* abortion of amplification for blastula biopsy
* PGD without diagnostic results or with unclear diagnostic results
* embryos with both HBA and HBB genetic defect

Primary outcomes:
measure: Gardner grading of blastocysts
timeFrame: embryo cultured in-vitro for 5-7 days
Secondary outcomes:
Other outcomes:
Locations:
city: Changsha
country: China
facility: Reproductive & Genetic Hospital of CITIC-XIANGYA
state: Hunan
Study officials:
affiliation: Reproductive & Genetic Hospital of CITIC-Xiangya
name: Liang Hu, MD,PHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03024567: Randomized Study on Salt Intake and Energy Metabolism
Official title: Effects of Increased Salt Intake on Energy Metabolism in Healthy Volunteers - a Randomized Clinical Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: Calorimetry
Blood pressure
Immunophenotyping
Gut microbial composition
Lead sponsor: Charite University, Berlin, Germany
Sponsor class: OTHER
First posted: 2017-01-19
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: To perform a randomized, double-blind clinical study on the effects of an increased salt intake on metabolic, cardiovascular and immunological parameters and the gut microbiota


Eligibility criteria: Inclusion Criteria:

* Healthy men and women
* 18 - 50 years
* Body mass index 18.5 - 29.9 kg/m2

Exclusion Criteria:

* Clinically relevant heart, lung, liver, and kidney diseases
* Current or chronic infection
* Habitual use of probiotics or dietary supplements
* Pregnancy, lactation

Primary outcomes:
measure: Dietary induced thermogenis (%)
timeFrame: 14 days
Secondary outcomes:
measure: Systolic blood pressure (mmHg)
timeFrame: 14 days
measure: Lymphocytic pro-inflammatory mediators
timeFrame: 14 days
measure: Gut microbiome
timeFrame: 14 days
Other outcomes:
Locations:
city: Berlin
country: Germany
facility: Experimental and Clinical Research Center
Study officials:
References:
citation: Mahler A, Klamer S, Maifeld A, Bartolomaeus H, Marko L, Chen CY, Forslund SK, Boschmann M, Muller DN, Wilck N. Increased Salt Intake Decreases Diet-Induced Thermogenesis in Healthy Volunteers: A Randomized Placebo-Controlled Study. Nutrients. 2022 Jan 7;14(2):253. doi: 10.3390/nu14020253.
Clinical trial NCT01008267: Shockwave Lithotripsy (SWL) Under Selective, General Anesthesia.
Official title: Shockwave Lithotripsy (SWL) Under Regular General Anesthesia and Under General Anesthesia Using Bronchial Blocker.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Renal Calculi
Ureteral Calculi
Lead sponsor: Assaf-Harofeh Medical Center
Sponsor class: OTHER_GOV
First posted: 2009-11-05
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who failed in SWL process taken under sedation (standard protocol)

Brief summary: SWL is widely used in the treatment of patients with renal and ureteral calculi. Several factors determine the success of extracorporeal shockwave lithotripsy (SWL) for kidney stones: stone size, stone location within the collecting system, stone type, and the SWL machine used. Moreover, in some cases it is very difficult to focus on the stone because of its movement as a results of breathing. In order to prevent stone movement we want to use a bronchial blocker, processing a selective ventilation of the opposite side of stone location.


Eligibility criteria: Inclusion Criteria:

* Older than 18 years old
* Not pregnant
* All patients who failed in SWL process, taken under sedation (standard protocol)

Exclusion Criteria:

* Age \< 18
* Pregnancy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Beer-Yaakov, Zrifin
country: Israel
facility: Anesthesiology department, Assaf-Harofeh MC
Study officials:
References: