Clinical trial NCT04580862: Postoperative Pain Endodontic Retreatment
Official title: Incidence Postoperative Pain After Single Visit Versus Two Visit Nonsurgical Endodontic Retreatment
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Endodontically Treated Teeth
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-10-09
Enrollment: 62
Sex: ALL
Minimum age (years): 20
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare the incidence of post-operative pain after single-visit versus two-visit non-surgical endodontic retreatment.

Detailed description: Post treatment failure could be treated by two options including orthograde retreatment and apical surgery . In a previous study, orthograde retreatments presented a success rate of 81 % classified as healed and 93 % as no symptoms and fully functional. In a systematic review, it has also been concluded that endodontic surgery offers more favorable initial success but orthograde retreatment yields to a better long-term outcome . Although early results of single-visit treatments are contradictory ; Completing the treatment in a single appointment reduces the treatment time and cost, decreases micro leakage risk and avoids recontamination of root canals between appointments in multiple-visit treatments . Again, reviewing the literature concerning primary treatment showed that, no significant differences were observed in healing of periapical radiolucency between teeth treated in single-visit and those treated in two-visits. Even, after using calcium hydroxide for four weeks . The presence of a positive bacterial culture at the time of filling did not influence the outcome of treatment .

Thorough online search revealed that, few studies are found concerning post- operative pain after single visit retreatment . The present study is designed to compare the effects of single-visit and two-visit root canal treatments on postoperative pain in retreatment cases. The primary outcome measure of this study is proposed to be whether single-visit root canal retreatment influenced the occurrence of postoperative pain as compared to two-visit treatment.

Eligibility criteria: Inclusion Criteria:

* Clinically asymptomatic.
* Previously treated teeth in need of retreatment due to leakage and/or improper filling.
* No periapical radiolucency.
* No percussion pains.
* Age 20 - 45.
* Premolar teeth.
* Male \& female.

Exclusion Criteria:

* Complicating compromised patient.
* Tenderness to percussion and acute apical abscess.
* Presence of an associated sinus tract.
* Presence of swelling in adjacent soft tissue.
* Teeth with periodontal pathologies or mobility.
* Teeth representing root fracture.
* Pregnant women.
* If analgesics or antibiotics have been administrated by the patient during the past 24 hours.

Primary outcomes:
measure: Incidence and intensity of postoperative
timeFrame: At one week after each visit
Secondary outcomes:
measure: Number of analgesic tablets
timeFrame: baseline
Other outcomes:
Locations:
Study officials:
References:
citation: Erdem Hepsenoglu Y, Eyuboglu TF, Ozcan M. Postoperative Pain Intensity after Single- versus Two-visit Nonsurgical Endodontic Retreatment: A Randomized Clinical Trial. J Endod. 2018 Sep;44(9):1339-1346. doi: 10.1016/j.joen.2018.05.017. Epub 2018 Jul 24.