Clinical trial NCT00089804: Study of LJP 394 in Lupus Patients With History of Renal Disease
Official title: A Randomized, Double-Blind, Placebo-Controlled, Three-Arm, Parallel-Group, Multicenter, Multinational Safety and Efficacy Trial of 300 mg and 900 mg of Abetimus Sodium in Systemic Lupus Erythematosus (SLE) Patients With a History of Renal Disease
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Lupus Erythematosus, Systemic
Lupus Nephritis
Keywords: Lupus
Nephritis
Kidney
SLE
Systemic Lupus Erythematosus
Nephritis, Lupus
Lead sponsor: La Jolla Pharmaceutical Company
Sponsor class: INDUSTRY
First posted: 2004-08-17
Enrollment: 943
Sex: ALL
Minimum age (years): 12
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary purpose of this study is to determine whether abetimus sodium is more effective than placebo in delaying time to renal flare in SLE patients with a history of renal disease.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of Systemic Lupus Erythematosus (SLE)
* Active SLE renal disease within past 4 years.
* Males or females between 12 and 70 years old.
* Females must be non-pregnant and non-lactating. Females and males must use adequate birth control methods during course of study.
* Ability to have weekly intravenous (IV) administration of study treatment.

Exclusion Criteria:

* Active SLE renal disease within past 3 months prior to entering study.
* Use of the following therapies within 3 months prior to entering the study: alkylating agents, e.g., cyclophosphamide, TNF inhibitors, cyclosporine.
* Use of mycophenolate mofetil that exceeds 1000 mg/day, azathioprine that exceeds 100 mg/day, methotrexate that exceeds 10 mg/week, leflunomide that exceeds 10 mg/day within 2 months prior to entering study.
* Use of rituximab within 6 months prior to entering study.
* Current abuse of drugs or alcohol.

Primary outcomes:
measure: To determine whether abetimus sodium is more effective than placebo in delaying the time to renal flare in SLE patients with a history of SLE renal disease. Weekly administration with a 52-week treatment duration.
timeFrame: Time to event (12 months fixed treatment duration)
Secondary outcomes:
measure: To determine whether treatment with abetimus sodium is more effective than placebo in delaying the time to Major SLE flare; and to determine whether treatment with abetimus sodium (LJP 394) is more effective than placebo in reducing proteinuria.
timeFrame: 12 month fixed treatment duration
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
city: Los Angeles
country: United States
facility: Wallace Rheumatic Study Center
state: California
city: San Leandro
country: United States
facility: East Bay Rheumatology Medical Group
state: California
city: San Mateo
country: United States
facility: Private Practice
state: California
city: Fort Lauderdale
country: United States
facility: CRIA Research
state: Florida
city: Miami
country: United States
facility: Miami Children's Hospital
state: Florida
city: Atlanta
country: United States
facility: Emory University School of Medicine, Renal Division
state: Georgia
city: Augusta
country: United States
facility: Private Practice
state: Georgia
city: Savannah
country: United States
facility: Southeast Regional Research Group
state: Georgia
city: Boise
country: United States
facility: Intermountain Orthopedics
state: Idaho
city: Chicago
country: United States
facility: Rheumatology Associates
state: Illinois
city: New Orleans
country: United States
facility: Ochsner Clinic Foundation
state: Louisiana
city: Greenbelt
country: United States
facility: SOMARC Trials, LLC
state: Maryland
city: Flushing
country: United States
facility: Nephrology Associates, PC
state: New York
city: Lake Success
country: United States
facility: North Shore - LIJ Health System
state: New York
city: Manhasset
country: United States
facility: Feinstein Institute for Medical Research
state: New York
city: New York
country: United States
facility: Seligman Center for Advanced Therapeutics, NYU Hospital for Joint Diseases
state: New York
city: Rochester
country: United States
facility: AAIR Research Center
state: New York
city: Syracuse
country: United States
facility: Suny Upstate Medical University
state: New York
city: Winston Salem
country: United States
facility: Wake Forest University Health Sciences
state: North Carolina
city: Columbus
country: United States
facility: Ohio State University Medical Center
state: Ohio
city: Tulsa
country: United States
facility: Healthcare Research Consultants
state: Oklahoma
city: Camp Hill
country: United States
facility: Private Practice
state: Pennsylvania
city: Duncansville
country: United States
facility: Altoona Center for Clinical Research
state: Pennsylvania
city: Jackson
country: United States
facility: Arthritis Clinic, 371 North Parkway, Suite 400
state: Tennessee
city: Amarillo
country: United States
facility: Amarillo Center for Clinical Research
state: Texas
city: Houston
country: United States
facility: Miracle Medical Clinic, 1170 Blalock Road
state: Texas
city: Houston
country: United States
facility: Renal Care Clinic, P.A., 17202 Red Oak Drive
state: Texas
city: Lubbock
country: United States
facility: Texas Tech University Health Sciences Center
state: Texas
city: San Antonio
country: United States
facility: San Antonio Kidney Disease Center
state: Texas
city: Fairfax
country: United States
facility: Clinical Research & Consulting Center
state: Virginia
city: Spokane
country: United States
facility: Arthritis Northwest PLLC
state: Washington
city: Buenos Aires
country: Argentina
facility: CIR Hospital Sirio Libanes. Campana 4658
state: Ciudad Autonma de
city: San Miguel de Tucumán
country: Argentina
facility: Centro de Investigaciones Reumatológicas
state: Provincia de Tucumán
city: Rosario
country: Argentina
facility: Instituto CAICI
state: Santa Fe
city: Buenos Aires
country: Argentina
facility: Organización Médica de la Investigación
state: Uruguay 725 P.B.
city: Buenos Aires
country: Argentina
facility: Unidad de Alergia, Asma e Inmunología Clínica
city: Buenos Aires
country: Argentina
facility: Centro de Investigaciones en Enfermedades Reumaticas (CIER)
city: Buenos Aires
country: Argentina
facility: Centro de Investigaciones Reumatologicas y Osteologicas
city: La Plata
country: Argentina
facility: Investigación Clínica Polivalente
city: Cairns
country: Australia
facility: Rheumatology Clinic
city: St Leonards
country: Australia
facility: Dept Medicine, Level 3 Wallace Freeborn Building, Royal North Shore Hospital, Pacific Highway
city: Victoria
country: Australia
facility: Vincents Hospital Daly Building, 41 Victoria Parade Fitzroy
city: Gomel
country: Belarus
facility: Gomel Regional Clinical Hospital
city: Minsk
country: Belarus
facility: Minsk City Clinical Hospital # 2
city: Minsk
country: Belarus
facility: Minsk City Clinical Hospital # 164
city: Minsk
country: Belarus
facility: Minsk City Clinical Hospital # 9
city: Minsk
country: Belarus
facility: Minsk Regional Clinical Hospital
city: Vitebsk
country: Belarus
facility: Vitebsk Regional Clinical Hospital
city: Porto Alegre-RS
country: Brazil
facility: Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul-PUCRS
state: Av. Ipiranga, 6690-Conj. 220-Jardim Botanico
city: Rio de Janeiro
country: Brazil
facility: Hospital Universitario Pedro Ernesto
state: Avenida 28 de Setembro, 77
city: Sao Paulo
country: Brazil
facility: Hospital Hehopolis
state: Avenida Almirante Delamare, 1534-Sacoman
city: Goiania-GO
country: Brazil
facility: Hospital Geral de Goiania, GO Av Anhanguera 6479 Setor Oeste
state: Goias
city: Belo Horizonte
country: Brazil
facility: Santa Casa de Misericórdia de BeloHorizonte, Av. Francisco Sales, n. 1111 9 andar Ala D/ CCIH
state: Minas Gerais
city: Goiänia, Goiás
country: Brazil
facility: Hospital das Clinicas da Faculdade de Medicina da Universidade, Federal de Goiás, Servico de Reumatologia / 2 andar
state: Primeira Avenida s/n Setor Universitário
city: Campinas - SP
country: Brazil
facility: Hospital de Clinicas - Universidade Estadual de Campinas - UNICAMP, Rua Vital Brasil, 250 - 3º andar - Cidade Universitária Zeferin
city: Campinas - Sāo Paulo
country: Brazil
facility: Hospital e Maternidade Celso Pierro - PUCCampinas, Av. John Boyd Dunlop, s/n
city: Curitiba - PR
country: Brazil
facility: Athritis Clinica de Doenças Reumaticas, Av. Padre Anchieta, 1846 cj 1108
city: Porto Alegre-RS
country: Brazil
facility: Hospital de Clinicas de Porto Alegre - HCPA
city: Ribeirão Preto
country: Brazil
facility: Hospital das Clínicas of Medicine School of University of São Paulo (USP) at Ribeirão Preto Rheumatology Department Avenida dos
city: Salvador - BA
country: Brazil
facility: Hospital Santa Izabel, Praca Almeida Couto, 500 - Naxaré
city: São Paulo
country: Brazil
facility: Irmandade da Santa Casa de Misericórdia de Sāo Paulo Rua, Dr. Cesário Motta Junior, 112
city: Săo Paulo - SP
country: Brazil
facility: Rua Pedro de Toledo 1800 9 andar/ Ala central - Diretoria de Servico de Reumatologia
city: Sofia
country: Bulgaria
facility: NMTranspH "Tsar Boris Treti", Clinic of Internal Diseases
state: 104 "Maria Louisa" blvd.
city: Stara Zagora
country: Bulgaria
facility: MHAT "Stara Zagora", Second Clinic of Internal Diseases
state: 11 "Armeiska" street
city: Sofia
country: Bulgaria
facility: MHAT "Sveti Ivan Rilski", Clinic of Rheumatology
state: 13 "Urvich" Street
city: Plovdiv
country: Bulgaria
facility: MHAT "Sveti Georgi", Clinic of Rheumatology
state: 15A "Vasil Aprilov" blvd.
city: Sofia
country: Bulgaria
facility: Military Medical Academy, Clinic of Urology and Nephrology
state: 3, Georgi Sofiiski, str.
city: Sofia
country: Bulgaria
facility: Clinic of Nephrology, MHAT "Alexandrovska" 1, Georgi Sofiiski, str.,
city: Plzen
country: Czech Republic
facility: Fakultni nemocnice Plzen, Oddeleni klinické farmakologie
state: Edvarda Benese
city: Praha 2
country: Czech Republic
facility: VFN Prahal Lékarská fakulta, Klinika detského a dorostového lékarstvi,
state: Ke Karlovu, 09 Praha 2,
city: Praha 2
country: Czech Republic
facility: Revmatologický ústav
city: Tbilisi
country: Georgia
facility: Academic VL Tsitlanadze Scientific - Practical Center of Rheumatology
city: Bad Nauheim
country: Germany
facility: Herz and Rheumazentrum Kerckhoff-klinik GmbH
state: Benekestrasse 2-8
city: Berlin
country: Germany
facility: Charité-Unversitätmedizin Berlin, CharitéCentrum Inn ere Medizin und Dermatologie
state: Chariteplatz 1
city: Leipzig
country: Germany
facility: Medizinische Klinik und Poliklinik IV des Universitätsklinikum Lepizig, Rheumatologie
state: Liebigstrasse 22
city: Göttingen
country: Germany
facility: Georg August Universität Göttingen Universitätsklinikum, Zentrum Innere Medizin
state: Robert-Kochstr. 40
city: Mainz
country: Germany
facility: Johannes Gutenberg-Universität I. Medizinische Klinik und Poliklinik,Langenbeckstr. 1
city: Hong Kong
country: Hong Kong
facility: Hong Kong University, Queen Mary Hospital
city: Hong Kong
country: Hong Kong
facility: The Chinese University of Hong Kong, Prince of Wales Hospital
city: Budapest
country: Hungary
facility: Szent Margit Hospital, Department of Nephrology
city: Budapest
country: Hungary
facility: Diagnostic Units Hungary Kft.
city: Budapest
country: Hungary
facility: Szent László Kórház, VI. Fertőző Belosztály
city: Debrecen
country: Hungary
facility: Debrecen Medical University
city: Gyor
country: Hungary
facility: Petz Aladar Megyei Oktato Korhaz, Immunnephrologia es Hypertonia Osztaly
city: Hyderabaad
country: India
facility: Global Hospitals
state: Andhra Pradesh
city: New Delhi
country: India
facility: Department of Nephrology, All India Institute of Medical Sciences
state: Ansari Nagar
city: Ahmedabad
country: India
facility: Institute of Kidney Diseases and Research (IKRD) and Institute of Transplantation Sciences (ITS)
state: Asarwa
city: Porur
country: India
facility: Sri Ramachandra Medical College & Research Institute (Deemed University)
state: Chennai
city: Jamnagar
country: India
facility: M.P. Shah Medical College & G.G. Hospital
state: Gujarat
city: Cochin
country: India
facility: PVS Memorial Hospital Ltd.
state: Kaloor, Kerala
city: Kolkatta
country: India
facility: Apollo Gleneagles Hospital
state: Kankurgachi
city: Bangalore
country: India
facility: St. Johns Medical College and Hospital, Dept. of Nephrology
state: Karnataka
city: Bangalore
country: India
facility: M.S. Ramaiah Memorial Hospital
state: Karnataka
city: Kochin
country: India
facility: Amrita Institute of Medical Sciences
state: Kerala
city: Hyderabaad
country: India
facility: Consultant and Head Department of Nephrology, Kamineni Hospitals
state: L.B. Nagar
city: Madurai
country: India
facility: Apollo Specialty Hospitals, Lake View Road, K.K., Nagar
state: Tamil Nadu
city: Noida
country: India
facility: Fortis Hospital, Dept. of Nephrology & Hypertension
state: Uttar Pradesh
city: Chandigarh
country: India
facility: Post Graduate Institute of Medical Education and Research
city: Chennai
country: India
facility: Devaki Hospital Ltd., Dept. of Nephrology
city: Chennai
country: India
facility: Madras Institute of Nephrology, Vijaya Health Center
city: Chennai
country: India
facility: Spectra Apollo Research Foundation
city: Hyderabaad
country: India
facility: Medwin Hospital
city: Hyderabaad
country: India
facility: Nizams Institute of Medical Sciences
city: Hyderabad
country: India
facility: Department of Nephrology, CARE Hospital, Banjara Hills
city: Kolkata
country: India
facility: Armenian Church Trauma Center - Unit of Rabindranath Tagore International Institute of Cardiac Sciences
city: Lucknow
country: India
facility: Sanjay Ghandi Post Graduate Institute of Medical Sciences
city: Mumbai
country: India
facility: BYL Nair Charitable Hospital & TN Medical College
city: Mumbai
country: India
facility: Seth G.S. Medical College & KEM Hospital
city: Mumbai
country: India
facility: P.D. Hinduja National Hospital and Research Center
city: Mysore
country: India
facility: Department of Nephrology, JSS Hospital, Ramanuja Road
city: New Delhi
country: India
facility: Indraprastha Apollo Hospital
city: Pune
country: India
facility: Jehangir Hospital, 32 Sassoon Road
city: Trivandrum
country: India
facility: Medical College Trivandrum
city: Visakhapatnam
country: India
facility: King George Hospital
city: Malang
country: Indonesia
facility: Dept. of Internal Medicine, Saiful Anwar General Hospital
state: Jl. J.A. Suprapto No. 2
city: Jakarta
country: Indonesia
facility: RS Kramat 128
state: Jl. Kramat Raya, Pusat
city: Bandung
country: Indonesia
facility: RS Hasan Sadikin
state: Jl. Pasir Kaliki No. 190, Jawa Barat
city: Ferrara
country: Italy
facility: Arcispedale S. Anna, Divisione di Reumatologia
state: Corso Giovecca 203
city: Padova
country: Italy
facility: Azienda Ospedaliera Cattedra di Reumatologia
state: Via Giustiniani, 2
city: Pisa
country: Italy
facility: Universita di Pisa, Dipartimento di Medicina Interna
state: Via Roma 67
city: Seoul
country: Korea, Republic of
facility: Ewha Woman's University College of Medicine, Mockdong Hospital
state: Yangcheon-Gu
city: In Cheon
country: Korea, Republic of
facility: Inha University Hospital
city: Kyonggi-do
country: Korea, Republic of
facility: Bundang Cha General Hospital, Pochon Cha University
city: Pusan
country: Korea, Republic of
facility: Pusan National University Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital, Department of Internal Medicine
city: Seoul
country: Korea, Republic of
facility: The Hospital for Rheumatic Disease, Hanyang University Medical Center
city: Seoul
country: Korea, Republic of
facility: Kangnam St. Mary's Hospital, Catholic University of Korea
city: Seoul
country: Korea, Republic of
facility: St. Mary's Hospital, Catholic University of Korea
city: Suwon
country: Korea, Republic of
facility: Ajou University Medical Center, Ajou University School of Medicine
city: Rayak
country: Lebanon
facility: Rayak Hospital
state: Bekaa Valley
city: Haykaliyeh-Tripoli
country: Lebanon
facility: Albert Haykel Hospital
city: Nabatieh
country: Lebanon
facility: Nabatieh Governmental Hospital
city: Saida
country: Lebanon
facility: Hammoud Hospital University Medical Center
city: Saida
country: Lebanon
facility: Labib Medical Center
city: Pulau Pinang
country: Malaysia
facility: Department of Medicine, Hospital Pulau Pinang,
state: Jalan Residensi
city: Sabah
country: Malaysia
facility: CAPD Unit, Queen Elizabeth Hospital,
state: Kota Kinabalu
city: Sarawak
country: Malaysia
facility: Department of Medicine, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce,
state: Kuching
city: Tijuana
country: Mexico
facility: Blvd. Sanchez Taboada 9250-28 - Private Practice
state: Baja California
city: Delagacion Tlalpan
country: Mexico
facility: Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran", Departmento de inmunologia y Reumatologia
state: D.f.
city: Mexico City
country: Mexico
facility: Clínica de Diagnóstico y Tratamiento de las Enfermedades Reumáticas
state: D.f.
city: Leon
country: Mexico
facility: Hospital Aranda de la Parra
state: Guanajuato
city: Guadalajara
country: Mexico
facility: Colomos #2292, Col. Providencia
state: Jalisco
city: Guadalajara
country: Mexico
facility: Centro de Estudios de Investigación Básica y Clínica S.C.
state: Jalisco
city: Morelia
country: Mexico
facility: Hospital Star Medica
state: Michoacan
city: Chihuahua
country: Mexico
facility: Poliplaza Medica
city: Mexicali
country: Mexico
facility: Reumatologia
city: Sonora
country: Mexico
facility: Hospital Privado San José de Ciudad Obregón, S.A. de C.V. Coahuila No. 263 Sur. Col. Centro. Ciudad Obregón
city: Cebu
country: Philippines
facility: Chung Hua Hospital
city: Davao
country: Philippines
facility: Davao Doctors Hospital
city: Manila
country: Philippines
facility: Philippine General Hospital
city: Manila
country: Philippines
facility: Joint and Bone Center, University of Santo Tomas Hospital
city: Warszawa
country: Poland
facility: Klinika Medycyny, Transplantacyjnej i Nefrologii in Warszawa, Nowogrodzka 59, At SPZOZ Szpital Kliniczny
state: Dzieciatka Jezus-Centrum Leczenia Obrażeń, Lindleya 4
city: Gdansk
country: Poland
facility: Klinika Nefrologii, Transplantologii i Chorob Wewnetrznych - Akademickie Centrum Kliniczne - Szpital AMG
city: Katowice
country: Poland
facility: Klinika Chorob Wewnetrznych i Reumatologii - Gornoslaskie Centrum Medyczne, SPSK Nr 7 SL A M
city: Lodz
country: Poland
facility: Oddzial Kiliniczny Nefrologii Hipertensjologii i Transplantologii Nerek SPZOZ, Uniwersytecki Szpital Kliniczny nr 1
city: Lublin
country: Poland
facility: Klinika Reumatologii i Ukladowych Chorob Tkanki Lacznej
city: Poznan
country: Poland
facility: Akademii Medycznej w Poznaniu, Zaklad Reumatologii i Immunologii Klinicznej
city: Warszawa
country: Poland
facility: Klinika Chorób Tkanki Łącznej
city: Warszawa
country: Poland
facility: Klinika Nefrologii Dializoterapii I Chorob Wewnetrznych - Samodzielny Publiczny Centralny Szpital Kliniczny
city: Lisboa
country: Portugal
facility: Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria - Reumatologia
state: Av. Prof. Egas Moniz
city: Porto
country: Portugal
facility: Centro Hospitalar do Porto, EPE - Hospital de Santo Antonio, Departamento de Medicina - Unidade de Imunologia Clinica
state: Largo Prof. Abel Salazar
city: Vila Nova de Gaia
country: Portugal
facility: Centro Hospitalar de Vila Nova de Gaia
state: Rua Conceicao Fernandes
city: Lisboa
country: Portugal
facility: Centro Hospitalar de Lisboa Ocidental, EPE - Hospital de Egas Moniz, Unidade de Reumatologia
state: Rua da Junqueira, 126
city: Porto
country: Portugal
facility: Hospital de Sāo Jeāo, Servico de Nefrologia
city: San Juan
country: Puerto Rico
facility: RCMI Clinical Research Center, 1st Floor University Hospital Medical Center
city: Bucharest
country: Romania
facility: "Sf. Maria" Clinical Hospital
city: Bucharest
country: Romania
facility: "Ion Stoia" Center of Rheumatic Diseases
city: Cluj Napoca
country: Romania
facility: Emergency Clinical County Hospital Cluj
city: Iasi
country: Romania
facility: Rehabilitation Clinical Hospital
city: Belgrade
country: Serbia
facility: Institute of Nephrology and Urology Clinical Centre of Serbia
city: Belgrade
country: Serbia
facility: Institute of Rheumatology
city: Belgrade
country: Serbia
facility: University Medical Centre "Zvezdara", Clinical Department for Renal Diseases, Dimitrija Tucovica 161
city: Niska Banja
country: Serbia
facility: Institute of Prevention, Treatment and Rehabilitation of Rheumatoid and Cardiovascular Patients "Niska Banja"
city: Banska
country: Slovakia
facility: Reumatologicka ambulancia Fakultna nemocnica F D Roosevelta
state: Bystrica
city: Bratislava
country: Slovakia
facility: Reumatologicka ambulancia Fakultna nemocnica s poliklinikou Milosrdni bratia spol s r o
city: Barcelona
country: Spain
facility: Hospital Clinic i Provincial de Barcelona, Centre Ciutat, Facultat de Medicina, Servicio de Enfermedades Autoinmunes
state: Calle Villarroel, 170
city: Madrid
country: Spain
facility: Hospital Universitario La Paz, Servico de Medicine Interne Planta 10
state: Paseo de la Castellana 261
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d'Hebron, Servicia Medicina Interna, Edificio General, 3a Planta
state: Paseo Valle de Hebron 119-129
city: Colombo
country: Sri Lanka
facility: University Lupus Clinic of the Department of Clinical Medicine, Faculty of Medicine, University of Colombo, P.O. Box 271, No 25,
state: Kynsey Road
city: Dalin Town
country: Taiwan
facility: Buddhist Dalin Tzu Chi General Hospital, Vice Superintendent Room
state: Chia-Yi county
city: Kaohsiung Hsien
country: Taiwan
facility: Chang Gung Memorial Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung University Medical Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Veterans General Hospital
city: Keelung city
country: Taiwan
facility: Chang Gung Memorial Hospital - Keelung
city: Taichung City
country: Taiwan
facility: Chung Shan Medical University Hospital
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Tainan
country: Taiwan
facility: National Chang-Kung University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital - Immunology & Rheumatology Office
city: Taipei
country: Taiwan
facility: Chang Gung Memorial Hospital - Taipei
city: Taoyuan
country: Taiwan
facility: Chang Gung Memorial Hospital
city: Yongkang City
country: Taiwan
facility: Chi Mei Foundation Hospital
city: Bangkok
country: Thailand
facility: Department of Medicine, King Chulalongkorn Memorial Hospital
city: Bangkok
country: Thailand
facility: Ramathibodi Hospital - Division of Allergy, Immunology & Rheumatology, Dept. of Medicine
city: Bangkok
country: Thailand
facility: Rheumatic Disease Unit, Department of Internal Medicine, Phramongkutklao Hospital and College of Medicine
city: Donetsk
country: Ukraine
facility: Donetsk Central Municipal Clinical Hospital #1
city: Kyiv
country: Ukraine
facility: Kyiv Central Municipal Clinical Hospital
city: Kyiv
country: Ukraine
facility: M.D. Strazhesko Institute of Cardiology AMS Ukraine
city: Kyiv
country: Ukraine
facility: Kyiv Regional Clinical Hospital
city: Lviv
country: Ukraine
facility: Lviv Municipal Public Clinical Hospital
city: Vinnitsa
country: Ukraine
facility: Vinnitsa Regional Clinical Hospital of MoH of Ukraine
Study officials:
affiliation: Chief Medical Officer, La Jolla Pharmaceutical Company
name: Michael J Tansey, MD, Ph.D.
role: STUDY_DIRECTOR
References: