Clinical trial NCT04048291: Efficacy of Brisk Walking in Parkinson's Disease
Official title: Efficacy of Brisk Walking on Improving Balance and Gait Performance, and Functional Mobility in Parkinson's Disease - a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Parkinson Disease
Keywords: rehabilitation
exercise
postural balance
Lead sponsor: The Hong Kong Polytechnic University
Sponsor class: OTHER
First posted: 2019-08-07
Enrollment: 80
Sex: ALL
Minimum age (years): 30
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Parkinson's disease (PD) is the second most common neuro-degenerative disease in older people. Falls are common among people PD with the incidence rate up to 70% and have strong associations with the severity of the disease, balance impairment, and freezing of gait.The abnormal gait characteristics include reduction in stride length, gait speed and arm swing, and increase in cadence. Gait training, balance training, aerobic training, Tai chi and dance training are common types of physical rehabilitation for PD. Brisk walking is a way of walking with a pace faster than normal, and it can improve dynamic balance for senior men and balance function for chronic stroke clients.

Brisk walking also promotes cardiopulmonary fitness and walking endurance in elderly women, healthy middle-age and older adults, active elderly men and chronic stroke clients. Our previous pilot randomized controlled trial on the effects of a 6-week home-based brisk walking program indicates that it is feasible and safe for the early PD population with improved walking capacity measured by 6-minute walk distance. The positive effects could carry over to 6 weeks after treatment completion. Up-to-date, the short- and long-term effects of brisk walking in improving balance and gait performance, and functional capacity in people with PD have not yet been well investigated. In order to promote their balance and functional capacity in longer term, more sustained training and better exercise adherence may be necessary.


Eligibility criteria: Inclusion Criteria:

* Parkinson disease diagnosed by neurologist with Hoehn \& Yahr stage 2 or 3
* Having a 30-meter walking ability

Exclusion Criteria:

* Significant neurological condition (other than Parkinson's disease)
* Musculoskeletal conditions affecting gait, balance or upper limb functions
* Had received deep brain stimulation surgery
* Cognitive impairment with Montreal Cognitive Assessment score \<24
* Present with on-off motor fluctuations.

Primary outcomes:
measure: Mini-Balance Evaluation Systems Test (miniBest) total scores
timeFrame: 1 year
measure: Six-minute walking test (6MWT) distance
timeFrame: 1 year
measure: Movement Disorder Society Unified Parkinson Disease Rating Scale Part III (MDS-UPDRS-III) score
timeFrame: 1 year
Secondary outcomes:
measure: Fast gait speed
timeFrame: 1 year
measure: Dual-task timed-up-and-go-time
timeFrame: 1 year
measure: Movement Disorder Society Unified Parkinson Disease Rating Scale Part I (MDS-UPDRS-I) score
timeFrame: 1 year
measure: Activities-specific Balance Confidence (ABC) Scale score
timeFrame: 1 year
measure: Parkinson Disease Questionnaire-39 (PDQ-39) summary index score
timeFrame: 1 year
measure: Fall risk
timeFrame: 1 year
measure: Fall rate
timeFrame: 1 year
measure: Injurious fall risk
timeFrame: 1 year
measure: Injurious fall rate
timeFrame: 1 year
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: The Hong Kong Polytechnic University
state: Nothing Selected
Study officials:
affiliation: Department of Rehabilitation Sciences,The Hong Kong Polytechnic University
name: Margaret K Mak, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Mak MK, Wong-Yu IS, Shen X, Chung CL. Long-term effects of exercise and physical therapy in people with Parkinson disease. Nat Rev Neurol. 2017 Nov;13(11):689-703. doi: 10.1038/nrneurol.2017.128. Epub 2017 Oct 13.
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citation: Mak M, Chan W, Auyeung M, Chan A, Cheung N, Mok V. Effects of a home-based brisk walking program in improving activity volume and walking capacity in people with Parkinson's disease. Fourth World Parkinson Congress Abstract; September 2016; Portland 2016.