louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01844466: Correlation of Visual and Motor Deficits in Stroke Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke
Keywords: course of motor and visual rehabilitation
improvement of deficits
stroke patients
Lead sponsor: University of Ioannina
Sponsor class: OTHER
First posted: 2013-05-01
Enrollment: 25
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a prospective study of patients with stroke with accompanying motor and visual deficits. There will be patients' evaluations at 2 time points at the acute and subacute period after the stroke. Statistical correlation of the improvement of their deficits will be conducted


Eligibility criteria: Inclusion Criteria:

acute phase stroke patients with motor and visual deficits

Exclusion Criteria:

previous stroke, neurologic disease or visual deficit

Primary outcomes:
measure: hemispheric stroke scale
timeFrame: participants will be followed for the duration of hospital stay, an expected average of 6 weeks from the time of stroke
measure: visual fields exam
timeFrame: participants will be followed for the duration of hospital stay, an expected average of 6 weeks from the time of stroke
Secondary outcomes:
Other outcomes:
Locations:
city: Ioannina
country: Greece
facility: University Hospital of Ioannina
Study officials:
References:
Clinical trial NCT01896466: Enhanced Gait and Balance Training
Official title: Influence of Neuromodulation on Gait and Balance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aging
Accidental Falls
Keywords: Fall Risk
Gait
Dynamic Balance
Static Balance
Neuromodulation
Lead sponsor: University of Wisconsin, Madison
Sponsor class: OTHER
First posted: 2013-07-11
Enrollment: 39
Sex: ALL
Minimum age (years): 18
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is twofold:

1. Establish baseline measures of gait performance in healthy young and older adults, and older adults with a history of falls.
2. Investigate the effects of gait and balance training with and without cranial nerve noninvasive neuromodulation (CN-NINM) on postural balance and gait performance in older adults.

For the second purpose, the study will incorporate a placebo-controlled design to evaluate the effects of CN-NINM augmented exercise compared to physical exercises alone. Both groups will perform gait and postural balance training (outlined in more detail below) but will differ in the stimulation level of the PoNS device. The investigators will use the results of this study as a first step toward evaluating the benefits of CN-NINM in a falls prevention program.


Eligibility criteria: Inclusion Criteria:

* Community-dwelling
* Able to understand and give informed consent
* Able to stand and walk independently without an assistive device
* No contraindication to exercise

  1. Healthy young adults
* Between ages of 18 and 39
* Scores above 19 on Dynamic Gait Index 2. Healthy older adults without a history of falls
* Age 65+
* Scores above 19 on Dynamic Gait Index 3. Older adults with a history of falls
* Age 65+
* Self-reported history of 1-3 falls in previous year
* Scores of 19 and below on the Dynamic Gait Index

Exclusion Criteria:

* History of musculoskeletal disorders (lower-limb joint replacement, radiographic evidence of severe osteoarthritis, broken leg bone or ligament/tendon injury in prior 6 months)
* Use of tobacco products
* Any oral abrasions, cuts, cold sores, piercings, tissue inflammation, or have had oral surgery within the previous 3 months
* Have a pacemaker or are identified as at-risk for cardiovascular events
* Have a biomechanical prosthetic
* If female, self-report of being pregnant
* Neurological condition
* Prisoners
* Individuals clearly lacking the capacity to provide informed consent

Primary outcomes:
measure: Dynamic Gait Index
timeFrame: Day 1 and approximately Day 12
Secondary outcomes:
Other outcomes:
Locations:
city: Madison
country: United States
facility: University of Wisconsin Hospital and Clinics
state: Wisconsin
Study officials:
affiliation: University of Wisconsin, Madison
name: Darryl G Thelen, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02513966: Decreased Consumption of Blood Components During Cardiac Surgery Procedures: Causes and Effects.
Official title: Decreased Consumption of Blood Components During Cardiac Surgery Procedures: Causes and Effects.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Blood Safety
Blood Transfusion
Lead sponsor: Universitaire Ziekenhuizen KU Leuven
Sponsor class: OTHER
First posted: 2015-08-03
Enrollment: 7835
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients undergoing cardiac surgery from 2010 untill 2014 in the University Hospitals of Leuven.

Brief summary: There is a decrease in the amount of blood components used during cardiac surgery in the last four years. As the hemovigilance team of the investigators' Hospital the investigators want to find out the causes and effects of this decrease.


Eligibility criteria: Inclusion Criteria:

* patient underwent cardiac surgery between 2010 and 2014 in UZ Leuven

Exclusion Criteria:

* patient without cardiac surgery

Primary outcomes:
measure: amount of blood use during Cardiac surgery
timeFrame: 5years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Universitaire Ziekenhuizen KU Leuven
name: Timothy Devos, master
role: STUDY_CHAIR
References:
Clinical trial NCT00355966: Comparison of Misoprostol and PGE2 Gel for Induction of Labour in Women With Premature Rupture of Membranes at Term
Official title: Comparison of Misorostol & PGE2 Gel for Immediate Induction of Labour for Premature Ropture of Membranes at Term
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Premature Rupture of Membranes at Term
Keywords: Premature rupture of membranes
Induction of labour with Misoprostol
Induction of labour with PGE2 gel
Lead sponsor: Nilratan Sircar Medical College
Sponsor class: OTHER_GOV
First posted: 2006-07-25
Enrollment: 212
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Induction of labour with vaginal misoprostol, in women with premature rupture of membranes at term, results in significant shortening of induction to delivery time in comparison to vaginal PGE2 gel induction.


Eligibility criteria: Inclusion Criteria:

* Premature rupture of membranes at 37 or more weeks
* Single live fetus in cephalic presentation

Exclusion Criteria:

* Women in labour
* Women with contraindication of induction of labour
* Women with previous caesarean section or uterine surgery

Primary outcomes:
measure: Admission to delivery time
timeFrame: 48 hours
Secondary outcomes:
measure: Caesarean Section rate
timeFrame: 48 hours
measure: Neonatal morbidity
timeFrame: Till discharge
measure: Maternal morbidity
timeFrame: Till discharge
Other outcomes:
Locations:
city: Kolkata
country: India
facility: NRS Medicl College,138 AJC Bose Road
state: West Bengal
Study officials:
affiliation: NRS Medical College , Kolkata, India
name: Snehamay Chaudhuri, MBBS,MD,DNB
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06017466: Translation and Implementation of the Dutch VVAS Score in Clinical Practice
Official title: Translation and Implementation of the Dutch VVAS Score in Clinical Practice
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Vertigo
Keywords: Vertigo
Epidemiology
Visually Induced Dizziness
Chronic Vertigo
Lead sponsor: Universitair Ziekenhuis Brussel
Sponsor class: OTHER
First posted: 2023-08-30
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: This will be a prospective interventional study with the Dutch VVAS questionnaire as interventional product.
Primary purpose: DEVICE_FEASIBILITY

Brief summary: The aim of this study is to translate and introduce a cross-cultural adaptation of The Visual Vertigo Analogue Scale (VVAS). E. Dannenbaum et al developed the VVAS in order to diagnose visual vertigo (VV). VV is dizziness caused by visual stimuli such as scrolling through a computer screen or walking through crowds of people or supermarket aisles.

Detailed description: The Visual Vertigo Analogue Scale (VVAS) was developed by E. Dannenbaum et al in 2011 to diagnose visual vertigo. It is a nine-item analogue scale in which the subjects can rate their symptoms' intensity. The symptoms can be categorized as None (0), Mild (0.1-40), Moderate (40.01-70), or Severe (70.01-100). The VVAS is already available in English and French but a Dutch version does not yet exist. In this study, we would like to translate and introduce a cross-cultural adaptation of the VVAS into Dutch for use with vestibular patients in Belgium.

Eligibility criteria: Inclusion Criteria:

* All patient with chronic vertigo (\>3 years) will included
* Interpretation of the VVAS is be possible
* 18-75 year

Exclusion Criteria:

* Unable to read Dutch
* Single episode of vertigo
* \> 75 year
* Minors
* When no interpretation of the VVAS is possible (e.g. too young, dementia)

Primary outcomes:
measure: vertigo symptoms assessed by the visual analogue scale
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04535466: Diagnosis Predictive Modle for Dense Density Breast Tissue Based on Radiomics
Official title: Development of an Artificial Intelligence Precise Diagnosis Predictive Modle for Dense Density Breast Tissue Based on Radiomics
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Breast Diseases
Artificial Intelligence
Dense Breast Density
Predictive Cancer Model
Lead sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sponsor class: OTHER
First posted: 2020-09-02
Enrollment: 1000
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Female patients aged 18-80 were included in our study who were diagnosed and treated at Sun Yat-sen memorial hospital .

Brief summary: It is a prospective, observational cohort study of patients with dense breast tissue. The study was based on the radiomics and other clinicopathological information of patients to establish the diagnostic system for breast disease by using artificial intelligence.


Eligibility criteria: Inclusion Criteria:

* Female patients with dense breast density tissue
* Digital breast tomosynthesis was performed
* Breast ultrasound examination was performed
* Pathologic examination of breast lesions was performed

Exclusion Criteria:

* Incomplete clinicopathologic data
* Female patients with fatty glands of the breast

Primary outcomes:
measure: the predictive model's area under curve(AUC)
timeFrame: follow up for 2 year for individuals
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Breast tumor center of Sun Yat-sen Memorial Hospital
state: Guangdong
Study officials:
References:
Clinical trial NCT06177366: A New Blood Score for Myelofibrosis Staging
Official title: Development of a Blood Score for Myelofibrosis Staging in BCR:ABL1 Negative Myeloproliferative Neoplasms Using Bone Marrow Biopsy as a Gold Standard
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Myeloproliferative Neoplasm
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2023-12-20
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults with MPN who need a bone marrow biopsy during the management of the disease

Brief summary: BCR:ABL1 negative myeloproliferative neoplasms (MPN) include three entities: polycythemia vera, essential thrombocythemia and primitive myelofibrosis. Myelofibrosis is a life-threatening complication in MPN with several therapeutic options including hematopoietic stem cell transplantation (HSCT) which remains the only curative treatment. Bone marrow biopsy with histological analysis allows myelofibrosis identification and staging. However, it is an invasive procedure that remains painful and provides potential haemorrhagic complications. Development of non-invasive biomarkers for myelofibrosis staging could help to better stratify this disease, better define patients' prognosis and lead to optimal cares.

The main aim of this work is to develop a non-invasive blood score including several biomarkers for myelofibrosis staging in MPN using bone marrow biopsy as a gold standard.


Eligibility criteria: Inclusion Criteria:

* Age \> 18 years
* Diagnosis of BCR::ABL1 negative MPN according to WHO criteria classification
* Indication for bone marrow biopsy
* Non opposition
* Social security affiliation

Exclusion Criteria:

* Non-contributory biopsy
* AML transformation
* Organ fibrosis (liver, lung, kidney...)
* HSCT
* Chronic inflammatory disease

Primary outcomes:
measure: Area under the curve
timeFrame: At diagnosis
Secondary outcomes:
measure: Number of patients
timeFrame: Up to 2 years
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03339466: Inspiratory Muscle Therapy in Subjects With Fontan Circulations
Official title: A Pilot Study of Inspiratory Muscle Function and the Effects of Inspiratory Muscle Training in Subjects With Fontan Physiology
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Single-ventricle
Lead sponsor: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Sponsor class: OTHER
First posted: 2017-11-13
Enrollment: 7
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Individuals who have undergone the Fontan procedure are uniquely dependent upon respiratory mechanics to support pulmonary blood flow (PBF). The investigators hypothesized that enhanced respiratory muscle function via inspiratory muscle training (IMT) would improve performance on cardiopulmonary exercise stress testing (CPET).

Detailed description: Adult Fontan subjects were recruited from 2 academic medical centers. Following characterization of pulmonary function and functional class, CPET was performed using incremental and constant work rate protocols. Subjects performed 6-8 weeks of IMT using a handheld inspiratory loading device (Threshold®, Philips); both exercise tests were then repeated. Patient-centered outcome data were collected before and after IMT (RAND-36 assessment and New York Heart Association (NYHA) functional class).

Eligibility criteria: Inclusion Criteria:

Single ventricle physiology status post Fontan palliation

Exclusion Criteria:

* The presence of a sub-pulmonary ventricle
* Pregnancy or any contraindication to stress testing (e.g., uncontrolled symptomatic arrhythmia, severe systemic ventricular outflow tract obstruction or uncontrolled symptomatic heart failure).
* Height less than 4'11" due to limitations of the cycle ergometer.

Primary outcomes:
measure: Exercise parameters
timeFrame: 6-8 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01026766: Effects of Heat and Moisture Exchanger in Combination With Air Forced Warming Blankets or Warming Intravenous Solutions on Intraoperative Hypothermia Prevention in Obese and Non Obese Patients During Intravenous Anesthesia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hypothermia
Keywords: Hypothermia
Obesity
Heat and moisture exchanger
Warming blanket
Warming fluids
Gynecological surgery
Intravenous anesthesia
Obese patients
Non obese patients
Lead sponsor: UPECLIN HC FM Botucatu Unesp
Sponsor class: OTHER
Collaborators: name: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
First posted: 2009-12-04
Enrollment: 40
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Forty female obese and non obese patients scheduled to gynecologic surgeries were warmed with warming blankets and warming intravenous fluids in association with heat and moisture exchanger.

Brief summary: The aim of the present study was to evaluate if the combination of heat and moisture exchanger with air forced warming blankets or warming intravenous fluids prevents intraoperative hypothermia in obese and non obese women under target controlled infusion-total intravenous anaesthesia (TCI-TIVA) during lower abdominal surgery.


Eligibility criteria: Inclusion Criteria:

* women
* 18-65 years old
* gynecologic
* obesity

Exclusion Criteria:

* fever
* endocrine disease
* hypertension
* vasoactive drugs

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Botucatu
country: Brazil
facility: College of Medicine of Botucatu
state: São Paulo
Study officials:
affiliation: Botucatu Medical School
name: Luciano A Fernandes, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02296866: Assessment of Prokinetic Effects of Erythromycin in Emergency Patients With a Full Stomach
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Emergency Surgery
Full Stomach
Lead sponsor: Hôpital Edouard Herriot
Sponsor class: OTHER
First posted: 2014-11-20
Enrollment: 28
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: all trauma patients with a full stomach, undegoing emergency surgery

Brief summary: The aims of the study is to assess whether the intravenous infusion of 3 mg/kg erythromycin has a significant gastrokinetic effect leading to empty the stomach in less than 90 minutes in non-fasting patients undergoing emergency trauma surgery.


Eligibility criteria: Inclusion Criteria:

* Emergency surgery for trauma
* ASA 1 and 2 patients
* Full stomach (antral area \> 550 mm²)
* Adult patients

Exclusion Criteria:

* No contraindication to erythromycin
* Extreme emergency surgery (time frame \< 90 min between arrival in the service and the start of the surgery)
* gastroparesis or pathology associated with gastroparesis

Primary outcomes:
measure: ultrasonographic measurement of antral area
timeFrame: 30 minutes and immediately before erythromycin infusion, and 30, 60 and 90 min after the start of erythromycin infusion
Secondary outcomes:
Other outcomes:
Locations:
city: Lyon
country: France
facility: Hopital Edouard Herriot
Study officials:
References:
Clinical trial NCT00508066: Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery
Official title: Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Scoliosis
Keywords: Congenital Scoliosis
Idiopathic Scoliosis
Spinal Fusion
Post-Operative Pain Management
Infusion Catheter
Lead sponsor: Shriners Hospitals for Children
Sponsor class: OTHER
First posted: 2007-07-27
Enrollment: 60
Sex: ALL
Minimum age (years): 8
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the effects of continuous local anesthetic delivery on the immediate post-op recovery of patients undergoing spinal fusion surgery for congenital or idiopathic scoliosis.

Detailed description: Constant local analgesic infusion is a relatively new modality that provides a constant supply of medication without the need for repeat injections. This method has shown encouraging results with respect to pain levels, narcotic use, faster rehabilitation and shorter hospital stay in patients undergoing laparotomies, iliac crest bone graft harvest, and sternotomies. In addition, there have not been any reported complications when used in these scenarios.

We hope to confirm better pain control, less narcotic use (i.e. PCA), fewer narcotic side effects, better response to physical therapy and earlier discharge. Which may be generalized to the spinal surgery patient population as less pain and suffering and a better overall hospital course

Eligibility criteria: Inclusion Criteria:

* Clinical Diagnosis of Congenital Scoliosis
* Clinical Diagnosis of Idiopathic Scoliosis
* Anticipated Spinal Fusion Surgery

Exclusion Criteria:

* Less than 8 years of age

Primary outcomes:
measure: VAS pain score
timeFrame: 72 hours
Secondary outcomes:
measure: Physical Therapy Progress
timeFrame: Post-op day 1, 2, 3
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: Shriners Hospitals for Children - Los Angeles
state: California
Study officials:
affiliation: Shriners Hospitals for Children - Los Angeles
name: Norman Otsuka, MD
role: STUDY_DIRECTOR
affiliation: Shriners Hospitals for Children - Los Angeles
name: Anthony Scaduto, MD
role: PRINCIPAL_INVESTIGATOR
References: