Clinical trial NCT06068374: Breaks From Sedentary Behavior With Dual Tasks in Elderly
Official title: Acute Effects of Breaks From Sedentary Behavior With Dual Tasks on Cerebral Blood Flow, Cognitive Function, Blood Pressure and Vascular Function in the Elderly
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aging
Keywords: sedentary behavior
physical activity
cognitive function
vascular function
Lead sponsor: University of Nove de Julho
Sponsor class: OTHER
First posted: 2023-10-05
Enrollment: 27
Sex: ALL
Minimum age (years): 60
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: The aim of this project will be to compare the acute effects of breaks from sedentary behavior using dual-tasking on cerebral blood flow, vascular function, cognitive functions and blood pressure in elderly people. Participants will perform, in random order, three experimental sessions (control, break with dual-task and standard break (\[walk\]). All sessions will have a period of 4 hours in sedentary behavior. In the standard break session and in the break session with dual-task participants will take walking and dual-task breaks every 30 minutes, and in the control session they will remain seated without breaks. Before and after this period, cerebral blood flow, vascular function, cognitive functions and blood pressure will be assessed.


Eligibility criteria: Inclusion Criteria:

* aged 60 years or over
* be physically independent based on the Katz Test
* have no history of heart attack
* not having suffered a stroke
* not have heart failure
* do not have joint problems that prevent them from carrying out experimental sessions
* do not have a history of neurodegenerative diseases
* obtain ≥ 26 points in the Montreal Cognitive Assessment (MoCA)
* are not involved in the practice of regular, systematic physical activity more than once a week over the last six months prior to the start of the study
* not be smokers and morbidly obese.

Primary outcomes:
measure: Cerebral blood velocity [centimeters per second]
timeFrame: Before and 20 minutes after the intervention for 5 minutes
measure: Cognitive function - The Trail Making Tests [seconds]
timeFrame: Before and 30 minutes after the intervention
measure: Cognitive function - Stroop test [seconds]
timeFrame: Before and 32 minutes after the intervention
measure: Cognitive function - verbal fluency [number of animal names reported]
timeFrame: Before and 35 minutes after the intervention
Secondary outcomes:
measure: Resting systolic and diastolic blood pressures [mmHg]
timeFrame: Before and 10 minutes after the intervention
measure: Resting heart rate [bpm]
timeFrame: Before and 10 minutes after the intervention
measure: Ambulatory systolic, diastolic, and mean blood pressures monitoring [mmHg]
timeFrame: 45 minutes after the intervention
measure: Vascular function [%]
timeFrame: Before and 10 minutes after the intervention
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Universidade Nove de Julho
Study officials:
affiliation: University of Nove de Julho
name: Raphael Dias, PhD
role: PRINCIPAL_INVESTIGATOR
References: