Clinical trial NCT04435626: Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone on Morbidity (Events Indicating Disease Worsening) & Mortality (Death Rate) in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40%
Official title: A Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Finerenone on Morbidity and Mortality in Participants With Heart Failure (NYHA II-IV) and Left Ventricular Ejection Fraction ≥ 40% (LVEF ≥ 40%)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Heart Failure
Keywords: Heart Failure with Preserved Ejection Fraction,
Mineralocorticoid receptor antagonist (MRA)
Lead sponsor: Bayer
Sponsor class: INDUSTRY
First posted: 2020-06-17
Enrollment: 6016
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits for HF(generally meaning a hospital stay or urgent presentation to a healthcare unit due to worsening symptoms of heart failure) in patients suffering from HF with an ejection fraction greater than or equal to 40%. Researchers will also collect information on how much the heart disease has impact on patient's lives, change of kidney function, and how well finerenone treatment is tolerated. The study plans to enroll 6000 male and female patients of the age of 40 years and above suffering from heart failure with ejection fraction greater than or equal to 40%. Participants will take the study product as oral tablet with a dose between 0 (Placebo) 40 mg once daily. Study duration will be up to 43 months.


Eligibility criteria: Inclusion Criteria:

* Participant (male or female) must be aged 40 years and older.
* Diagnosis of heart failure with New York Heart Association(NYHA) class II-IV, ambulatory or hospitalized primarily for heart failure.
* On diuretic treatment for at least 30 days prior to randomization.
* Documented left ventricular ejection fraction (LVEF) of ≥40% measured by any modality within the last 12 months.
* Structural heart abnormalities based on any local imaging measurement within the last 12 months, defined by at least one of the following findings: left atrial diameter (LAD) ≥3.8cm, left atrial area (LAA) ≥20cm2, left atrial volume index (LAVI) \>30 mL/m2, left ventricular mass index (LVMI) ≥115 g/m2 (♂)/ 95 g/m2 (♀), septal thickness or posterior wall thickness ≥1.1 cm
* n-terminal prohormone B-type natriuretic peptide (NT-proBNP) ≥300 pg/mL (BNP ≥100 pg/mL) in sinus rhythm and patient does not have an ongoing diagnosis of paroxysmal atrial fibrillation or NT-proBNP ≥900 pg/mL (BNP ≥300 pg/mL) in atrial fibrillation (or if atrial fibrillation status is unknown or if patient has an ongoing diagnosis of paroxysmal atrial fibrillation) for participants obtained at the following time:

  * Within 90 days prior to randomization if patient had been hospitalized for heart failure (HF) requiring initiation or change in HF therapy or if patient had an urgent visit for HF requiring intravenous (IV) diuretic therapy, both within 90 days prior to randomization OR
  * Within 30 days prior to randomization if patient has not been hospitalized for HF nor had an urgent HF visit within the past 90 days.
* Women of childbearing potential can only be included in the study if a pregnancy test is negative at screening and baseline and if they agree to use adequate contraception which is consistent with local regulations regarding the methods for contraception for those participating in clinical trials.

Exclusion Criteria:

* Estimated glomerular filtration rate (eGFR) \<25 mL/min/1.73 m² at either screening or randomization visit.
* Serum/plasma potassium \>5.0 mmol/L at either screening or randomization visit.
* Acute inflammatory heart disease, e.g. acute myocarditis, within 90 days prior to randomization
* Myocardial infarction or any event which could have reduced the ejection fraction within 90 days prior to randomization
* Coronary artery bypass graft surgery in the 90 days prior to randomization
* Percutaneous coronary intervention in the 30 days prior to randomization
* Stroke or transient ischemic cerebral attack within 90 days prior to randomization
* Probable alternative cause of participants' HF symptoms that in the opinion of the investigator primarily accounts for patient's dyspnea such as significant pulmonary disease, anemia or obesity. Specifically, patients with the below are excluded: Severe pulmonary disease requiring home oxygen, or chronic oral steroid therapy, History of primary pulmonary arterial hypertension, Hemoglobin \<10 g/dl, Valvular heart disease considered by the investigator to be clinically significant, Body Mass Index (BMI) \>50 kg/m2 at screening
* Systolic blood pressure(SBP) ≥160 mmHg if not on treatment with ≥3 blood pressure lowering medications or ≥180 mmHg irrespective of treatments, on 2 consecutive measurements at least 2-minute apart, at screening or at randomization.
* Concomitant systemic therapy with potent cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors (e.g. itraconazole, ritonavir, indinavir, cobicistat, clarithromycin) or moderate or potent CYP3A4 inducers, that cannot be discontinued 7 days prior to randomization and for the duration of the treatment period.

Primary outcomes:
measure: Number of cardiovascular deaths and heart failure events
timeFrame: Up to 42 months
Secondary outcomes:
measure: Time to total (first and recurrent) HF events
timeFrame: Up to 42 months
measure: Improvement in NYHA class from Baseline to Month 12
timeFrame: Up to 12 month after start of treatment
measure: Change in Total Symptom Score (TSS) from KCCQ.
timeFrame: At baseline, Months 6, 9 and 12
measure: Time to first occurrence of composite renal endpoint
timeFrame: Up to 42 months
measure: Time to death from any cause
timeFrame: Up to 42 months
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Cardiology, PC
state: Alabama
city: Fairhope
country: United States
facility: Eastern Shore Research Institute, LLC | Fairhope, AL
state: Alabama
city: Mobile
country: United States
facility: Mobile Heart Specialists, PC
state: Alabama
city: Tucson
country: United States
facility: University of Arizona Health Science Center
state: Arizona
city: Little Rock
country: United States
facility: Heart Clinic Arkansas
state: Arkansas
city: Beverly Hills
country: United States
facility: National Heart Institute
state: California
city: Cypress
country: United States
facility: California Heart Specialists
state: California
city: Orange
country: United States
facility: UC Irvine Medical Center
state: California
city: Sacramento
country: United States
facility: Sutter Heart & Vascular Institute
state: California
city: Santa Rosa
country: United States
facility: NorthBay Clinical Research, LLC | Santa Rosa, CA
state: California
city: Torrance
country: United States
facility: Harbor - UCLA Medical Center
state: California
city: Vista
country: United States
facility: Blue Coast Research Center, LLC
state: California
city: West Hills
country: United States
facility: Interventional Cardio Medical- DCT Department
state: California
city: West Hills
country: United States
facility: Interventional Cardiology Medical Group | West Hills, CA
state: California
city: Aurora
country: United States
facility: VA Eastern Colorado Health Care System
state: Colorado
city: Colorado Springs
country: United States
facility: Colorado Springs Cardiology
state: Colorado
city: Littleton
country: United States
facility: South Denver Cardiology Associates, PC
state: Colorado
city: Bradenton
country: United States
facility: Cardiovascular & Vein Center of Florida | Bradenton, FL
state: Florida
city: Bradenton
country: United States
facility: Nova Clinical Research | Brandenton, FL
state: Florida
city: Daytona Beach
country: United States
facility: Cardiology Associates Research Company
state: Florida
city: Gainesville
country: United States
facility: Malcom Randall VA Medical Ctr
state: Florida
city: Miami
country: United States
facility: LifeSpring Research Foundation, LLC
state: Florida
city: Naples
country: United States
facility: Southwest Florida Research | Naples, FL
state: Florida
city: Saint Augustine
country: United States
facility: East Coast Institute for Research | St. Augustine, FL
state: Florida
city: Wellington
country: United States
facility: Cardiology Partners
state: Florida
city: Columbus
country: United States
facility: IACT Health
state: Georgia
city: Tucker
country: United States
facility: Atlanta Heart Specialists, LLC
state: Georgia
city: Chicago
country: United States
facility: Advocate Illinois Masonic Medical Center
state: Illinois
city: Downers Grove
country: United States
facility: Advocate Good Samaritan Hospital
state: Illinois
city: Libertyville
country: United States
facility: Advocate Condell Medical Center
state: Illinois
city: Naperville
country: United States
facility: Edward Hospital-Main Campus
state: Illinois
city: North Chicago
country: United States
facility: Captain James A. Lovell Federal Health Care Center
state: Illinois
city: Peoria
country: United States
facility: Methodist Medical Center of Illinois
state: Illinois
city: Elkhart
country: United States
facility: Midwest Cardiovascular Research and Education Foundation
state: Indiana
city: Richmond
country: United States
facility: Reid Physician Associates | Cardiology Department
state: Indiana
city: Wichita
country: United States
facility: Kansas Nephrology Research Institute, LLC
state: Kansas
city: Paducah
country: United States
facility: Baptist Health Paducah
state: Kentucky
city: Covington
country: United States
facility: Cardiovascular Associates Research, LLC
state: Louisiana
city: Hammond
country: United States
facility: Heart Clinic of Hammond
state: Louisiana
city: Slidell
country: United States
facility: Louisiana Heart Center Research - Slidell
state: Louisiana
city: Zachary
country: United States
facility: Southern Clinical Research, LLC
state: Louisiana
city: Scarborough
country: United States
facility: Maine Medical Partners-Maine Health Cardiology
state: Maine
city: Baltimore
country: United States
facility: Cardiovascular Specialists of Central Maryland, PA
state: Maryland
city: Baltimore
country: United States
facility: Maryland Cardiovascular Specialists
state: Maryland
city: Baltimore
country: United States
facility: John Hopkins Outpatient Center
state: Maryland
city: Bethesda
country: United States
facility: Suburban Hospital
state: Maryland
city: Detroit
country: United States
facility: Henry Ford Health System
state: Michigan
city: Flint
country: United States
facility: Aa Mrc, Llc
state: Michigan
city: Kalamazoo
country: United States
facility: Western Michigan University School of Medicine
state: Michigan
city: Maplewood
country: United States
facility: M Health Fairview
state: Minnesota
city: Minneapolis
country: United States
facility: M Health Fairview Heart Clinic - Fulton
state: Minnesota
city: Saint Cloud
country: United States
facility: St. Cloud Hospital
state: Minnesota
city: Jackson
country: United States
facility: Baptist Heart -Cardiology - DCT Dept
state: Mississippi
city: Jackson
country: United States
facility: University of Mississippi Medical Center
state: Mississippi
city: Columbia
country: United States
facility: Harry S. Truman Memorial Veterans Hospital
state: Missouri
city: Kansas City
country: United States
facility: Clinical Research Consultants
state: Missouri
city: Kansas City
country: United States
facility: St. Luke's Mid America Heart Institute
state: Missouri
city: Springfield
country: United States
facility: Mercy Hospital Springfield
state: Missouri
city: Kalispell
country: United States
facility: Logan Health Research
state: Montana
city: Grand Island
country: United States
facility: CHI Health Clinic Heart Institute - Grand Island
state: Nebraska
city: Lincoln
country: United States
facility: CHI Health Nebraska Heart
state: Nebraska
city: Bridgewater
country: United States
facility: Advanced Heart Care, LLC | Bridgewater, NJ
state: New Jersey
city: Linden
country: United States
facility: NJ Heart | Linden, NJ
state: New Jersey
city: Manalapan
country: United States
facility: Garden State Heart Care
state: New Jersey
city: Bronx
country: United States
facility: Cardiac Care & Vascular Medicine
state: New York
city: Poughkeepsie
country: United States
facility: Hudson Valley Cardiovascular Practice, PC
state: New York
city: Riverhead
country: United States
facility: Division of Cardiovascular Research at Peconic Bay Med Ctr
state: New York
city: Rosedale
country: United States
facility: Laurelton Heart Specialists
state: New York
city: Saratoga Springs
country: United States
facility: Saratoga Clinical Research, LLC
state: New York
city: Stony Brook
country: United States
facility: Stony Brook University Medical Center
state: New York
city: Valley Stream
country: United States
facility: Northwell Health Phys. Partners Cardiology at Valley Stream
state: New York
city: Burlington
country: United States
facility: Kernodle Clinic West, Private Diagnostic Clinic PLLC
state: North Carolina
city: Chapel Hill
country: United States
facility: University of North Carolina
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest Baptist Health
state: North Carolina
city: Kettering
country: United States
facility: Kettering Health Network
state: Ohio
city: Marion
country: United States
facility: Rama Research LLC | Marion, OH
state: Ohio
city: Youngstown
country: United States
facility: Mercy Health - St. Elizabeth Youngstown Hospital
state: Ohio
city: Oklahoma City
country: United States
facility: South Oklahoma Heart Research, LLC
state: Oklahoma
city: Camp Hill
country: United States
facility: Capital Area Research, LLC
state: Pennsylvania
city: Doylestown
country: United States
facility: Doylestown Cardiology Associates-VIAA
state: Pennsylvania
city: Warwick
country: United States
facility: Kent Hospital
state: Rhode Island
city: Ladson
country: United States
facility: Trident Cardiology Associates, PA
state: South Carolina
city: Lancaster
country: United States
facility: Carolina Heart Specialists | Lancaster
state: South Carolina
city: Mount Pleasant
country: United States
facility: PMG Research of Charleston
state: South Carolina
city: Rapid City
country: United States
facility: Monument Health Clinical Research
state: South Dakota
city: Sioux Falls
country: United States
facility: Sanford USD Medical Center
state: South Dakota
city: Germantown
country: United States
facility: The Stern Cardiovascular Foundation, Inc.
state: Tennessee
city: Jackson
country: United States
facility: Apex Cardiology, LLC
state: Tennessee
city: Memphis
country: United States
facility: Lt. Col. Luke Weathers, Jr. VA Medical Center
state: Tennessee
city: Powell
country: United States
facility: Cardiovascular Research of Knoxville
state: Tennessee
city: Austin
country: United States
facility: Seton Heart Institute
state: Texas
city: Dallas
country: United States
facility: Texas Health Physicians Group - Dallas
state: Texas
city: Dallas
country: United States
facility: Southwest Family Medicine Associates
state: Texas
city: Fort Worth
country: United States
facility: Texas Health Physicians Group - Fort Worth
state: Texas
city: Galveston
country: United States
facility: University of Texas Medical Branch at Galveston
state: Texas
city: Humble
country: United States
facility: Houston Heart & Vascular Associates
state: Texas
city: Kerrville
country: United States
facility: South Texas Cardiovascular Consultants, PLLC / Kerrville, TX
state: Texas
city: McKinney
country: United States
facility: North Dallas Research Associate | McKinney, TX
state: Texas
city: Plano
country: United States
facility: ClinRx Research, LLC
state: Texas
city: San Antonio
country: United States
facility: South Texas Cardiovascular Consultants, PLLC
state: Texas
city: San Antonio
country: United States
facility: Clinical Advancement Center, PLLC
state: Texas
city: Tomball
country: United States
facility: Northwest Houston Heart Center
state: Texas
city: Salt Lake City
country: United States
facility: University of Utah Health Care
state: Utah
city: Fairfax
country: United States
facility: IMG Cardiology- Fairfax
state: Virginia
city: Falls Church
country: United States
facility: Virginia Heart
state: Virginia
city: Leesburg
country: United States
facility: Virginia Heart
state: Virginia
city: Norfolk
country: United States
facility: Sentara Norfolk General Hospital
state: Virginia
city: Salem
country: United States
facility: Salem VA Medical Center
state: Virginia
city: Winchester
country: United States
facility: Selma Medical Associates
state: Virginia
city: Madison
country: United States
facility: William S. Middleton Memorial Veterans Hospital
state: Wisconsin
city: Milwaukee
country: United States
facility: Aurora Saint Luke's Medical Center
state: Wisconsin
city: Wausau
country: United States
facility: Aspirus Research Institute
state: Wisconsin
city: Caba
country: Argentina
facility: IMOBA Investigaciones Clinicas
state: Buenos Aires
city: Coronel Suarez
country: Argentina
facility: Clínica Coronel Suarez
state: Buenos Aires
city: La Plata
country: Argentina
facility: Hospital Italiano de La Plata | Clinical Research Department
state: Buenos Aires
city: Lanus
country: Argentina
facility: Centro de Investigaciones Medicas Lanus | Research Department
state: Buenos Aires
city: Quilmes
country: Argentina
facility: Sanatorio Modelo Quilmes
state: Buenos Aires
city: San Martín
country: Argentina
facility: Corporación Médica de General San Martín
state: Buenos Aires
city: Zárate
country: Argentina
facility: Instituto de Investigaciones Clínicas Zárate
state: Buenos Aires
city: Buenos Aires
country: Argentina
facility: Hospital Militar Central "CIR. MY. C. Argerich"
state: Ciudad Auton. De Buenos Aires
city: Buenos Aires
country: Argentina
facility: Centro de Investigaciones Metabólicas
state: Ciudad Auton. De Buenos Aires
city: Buenos Aires
country: Argentina
facility: Instituto Cardiovascular de Buenos Aires - Buenos Aires, Argentina
state: Ciudad Auton. De Buenos Aires
city: Caba
country: Argentina
facility: Centro de Investigaciones Clínicas
state: Ciudad Auton. De Buenos Aires
city: Villa Luro
country: Argentina
facility: Centro de Especialidades Medicas (Cemedic) | Cardiology Department
state: Ciudad Auton. De Buenos Aires
city: Rosario
country: Argentina
facility: Instituto Cardiovascular
state: Santa Fe
city: Rosario
country: Argentina
facility: Instituto Médico de la Fundación Estudios Clinicos
state: Santa Fe
city: San Miguel de Tucuman
country: Argentina
facility: Instituto de Cardiologia | Tucuman, AR
state: Tucuman
city: Corrientes
country: Argentina
facility: Inst. de Cardiología de Corrientes Juana Francisca Cabral
city: Córdoba
country: Argentina
facility: Clínica Privada del Prado
city: Córdoba
country: Argentina
facility: Instituto Médico DAMIC- Fundación Rusculleda
city: Santa Fe
country: Argentina
facility: Centro de Investigaciones Clinicas del Litoral
city: New Lambton Heights
country: Australia
facility: John Hunter Hospital
state: New South Wales
city: Auchenflower
country: Australia
facility: The Wesley Hospital
state: Queensland
city: Herston
country: Australia
facility: Royal Brisbane and Women's Hospital
state: Queensland
city: Bedford Park
country: Australia
facility: Flinders Medical Centre
state: South Australia
city: Leabrook
country: Australia
facility: Advara HeartCare Leabrook
state: South Australia
city: Bundoora
country: Australia
facility: Advara HeartCare Ringwood
state: Victoria
city: Chermside
country: Australia
facility: The Prince Charles Hospital
city: Klagenfurt
country: Austria
facility: Klinikum Klagenfurt am Wörthersee
state: Kärnten
city: St. Pölten
country: Austria
facility: Universitätsklinikum St. Pölten
state: Niederösterreich
city: Braunau
country: Austria
facility: Krankenhaus St. Josef Braunau
state: Oberösterreich
city: Graz
country: Austria
facility: Medizinische Universität Graz
state: Steiermark
city: Feldkirch
country: Austria
facility: Landeskrankenhaus Feldkirch
state: Vorarlberg
city: Salzburg
country: Austria
facility: Uniklinikum Salzburg - Landeskrankenhaus
city: Wien
country: Austria
facility: Universitätsklinikum AKH Wien
city: Wien
country: Austria
facility: Imed19-privat
city: Wien
country: Austria
facility: Klinik Floridsdorf - Krankenhaus Nord
city: Salvador
country: Brazil
facility: Santa Casa de Misericórdia da Bahia
state: Bahia
city: Brasilia
country: Brazil
facility: Hospital do Coração do Brasil
state: Distrito Federal
city: Goiânia
country: Brazil
facility: Hospital das Clinicas da Universidade Federal de Goias | Centro de Pesquisa em Cardiologia
state: Goiás
city: Curitiba
country: Brazil
facility: Quanta Diagnostico Por Imagem | Research and Innovation Department
state: Parana
city: Paraná
country: Brazil
facility: Sociedade Hospitalar Angelina Caron | Departamento de Ensino e Pesquisa
state: Parana
city: Caxias do Sul
country: Brazil
facility: Fundação Universidade de Caxias do Sul
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre | Clinical Research Center - Surgery Research Center
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Mae de Deus
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: FZ Pesquisa e Servicos em Cardiologia | Porto Alegre, Brazil
state: Rio Grande Do Sul
city: Blumenau
country: Brazil
facility: MK Consultoria Médico Científica Ltda/Angiocor Blumenau
state: Santa Catarina
city: Belo Horizonte
country: Brazil
facility: Hospital Felício Rocho
state: Sao Paulo
city: Campinas
country: Brazil
facility: Campinas Clinical Research Institute (IPECC) | Campinas, Brazil
state: Sao Paulo
city: Marília
country: Brazil
facility: Instituto do Coração de Marilia | Marilia, Brasil
state: Sao Paulo
city: Ribeirão Preto
country: Brazil
facility: Centro Avançado de Pesquisa para Diagnóstico - CAPED
state: Sao Paulo
city: Tatui
country: Brazil
facility: IMC - Instituto de Moléstias Cardiovasculares Tatui
state: Sao Paulo
city: Votuporanga
country: Brazil
facility: Santa Casa de Misericórdia de Votuporanga
state: Sao Paulo
city: Aracaju
country: Brazil
facility: Centro de Pesquisa Clinica do Coração | Aracaju, Brasil
state: Sergipe
city: Campinas
country: Brazil
facility: Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas
city: Minas Gerais
country: Brazil
facility: Eurolatino Pesquisas Medicas | Uberlandia, MG
city: Burgas
country: Bulgaria
facility: Ambulatory facility for specialized outpatient medical care
city: Haskovo
country: Bulgaria
facility: MHAT Haskovo
city: Pazardjik
country: Bulgaria
facility: MHAT Zdrave
city: Pernik
country: Bulgaria
facility: ¿ultidisc. hosp. for act. treatm. Sveti Georgi - Pernik OOD
city: Pleven
country: Bulgaria
facility: Medical Center Medconsult Pleven
city: Plovdiv
country: Bulgaria
facility: Medical centre Hipokrat - N EOOD
city: Plovdiv
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Medline | Cardiology Department
city: Plovdiv
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Sveta Karidad | Cardiology Department
city: Shumen
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment | Shumen - First Department of Internal Medicine
city: Sliven
country: Bulgaria
facility: MHAT Hadzhi Dimitar
city: Sofia
country: Bulgaria
facility: Second Medical Center Sofia EOOD
city: Sofia
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Knyaginya Klementina Sofia EAD | Cardiology Department
city: Sofia
country: Bulgaria
facility: NMTH Tzar Boris III
city: Sofia
country: Bulgaria
facility: MHAT National Cardiology Hospital EAD
city: Sofia
country: Bulgaria
facility: Medical Center Hera
city: Sofia
country: Bulgaria
facility: UMHAT Tsaritsa Joanna-ISUL EAD Sofia
city: Sofia
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Sveta Sofia | Internal Diseases Department
city: Stara Zagora
country: Bulgaria
facility: MHAT Trakia
city: Veliko Tarnovo
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Dr. Stefan Cherkezov | Cardiology Department
city: Yambol
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Sveti Panteleymon Yambol | Cardiology Department
city: New Westminster
country: Canada
facility: Fraser Clinical Trials, Inc.
state: British Columbia
city: Winnipeg
country: Canada
facility: St. Boniface Hospital
state: Manitoba
city: Moncton
country: Canada
facility: G.A. Research Associates, Ltd.
state: New Brunswick
city: Halifax
country: Canada
facility: Queen Elizabeth II Health Sciences Centre
state: Nova Scotia
city: Brampton
country: Canada
facility: Brampton Clinical Trials
state: Ontario
city: Cambridge
country: Canada
facility: Cambridge Cardiac Care Center
state: Ontario
city: Cambridge
country: Canada
facility: Vizel Cardiac Research
state: Ontario
city: London
country: Canada
facility: London Health Sciences Centre
state: Ontario
city: Mississauga
country: Canada
facility: KMH Cardiology Clinics Inc.
state: Ontario
city: North York
country: Canada
facility: North York Diagnostic and Cardiac Centre
state: Ontario
city: Oakville
country: Canada
facility: Oakville Cardiovascular Research
state: Ontario
city: Oshawa
country: Canada
facility: Office of Dr. James Cha, MD
state: Ontario
city: Peterborough
country: Canada
facility: Kawartha Cardiology Clinical Trials
state: Ontario
city: Scarborough
country: Canada
facility: Corcare
state: Ontario
city: Toronto
country: Canada
facility: Medicus MFC Inc.
state: Ontario
city: Toronto
country: Canada
facility: Women's College Hospital
state: Ontario
city: Toronto
country: Canada
facility: Mount Sinai Hospital
state: Ontario
city: Laval
country: Canada
facility: Centre intégré de santé et de services sociaux de Laval, Hôp
state: Quebec
city: Montreal
country: Canada
facility: Clinique Sante Cardio MC
state: Quebec
city: Montreal
country: Canada
facility: Centre Hospitalier de l'Université de Montréal-CHUM
state: Quebec
city: Montreal
country: Canada
facility: Montreal General Hospital
state: Quebec
city: Fuzhou
country: China
facility: Fujian Provincial Hospital
state: Fujian
city: Lanzhou
country: China
facility: Lanzhou University Second Hospital
state: Gansu
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Sun Yat-Sen University
state: Guangdong
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital
state: Guangdong
city: Guangzhou
country: China
facility: Sun Yat-Sen Memorial Hosp. Sun Yat-Sen Univ.
state: Guangdong
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Guangzhou University of TCM
state: Guangdong
city: Guangzhou
country: China
facility: Nanfang Hospital, Southern Medical University
state: Guangdong
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Jinan University
state: Guangdong
city: Guiyang
country: China
facility: Guizhou Provincial People's Hospital
state: Guizhou
city: Haikou
country: China
facility: Hainan Provincial People's Hospital
state: Hainan
city: Sanya
country: China
facility: Hainan Third People's Hospital (Province Nongken Sanya Hopt)
state: Hainan
city: Shijiazhuang
country: China
facility: The First Hospital of Hebei Medical Univesity
state: Hebei
city: Daqing
country: China
facility: Daqing Oilfield General Hospital
state: Heilongjiang
city: Xinxiang
country: China
facility: Xinxiang Central Hospital
state: Henan
city: Changsha
country: China
facility: Changsha Central Hospital
state: Hunan
city: Changsha
country: China
facility: Hunan Provincial People's Hospital
state: Hunan
city: Changsha
country: China
facility: The Third Xiangya Hospital of Central South University
state: Hunan
city: Huai'An
country: China
facility: Huai'an First People's Hospital, Nanjing Medical University
state: Jiangsu
city: Lianyungang
country: China
facility: The First People's Hospital of Lianyungang
state: Jiangsu
city: Nanjing
country: China
facility: The Second Affiliated Hospital of Nanjing Medical university
state: Jiangsu
city: Nanjing
country: China
facility: NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School
state: Jiangsu
city: Nanjing
country: China
facility: Zhongda Hospital Southeast University
state: Jiangsu
city: Nanjing
country: China
facility: Nanjing Jiangning Hospital
state: Jiangsu
city: Nanjing
country: China
facility: Jiangsu Province Hospital
state: Jiangsu
city: Suzhou
country: China
facility: 1st Affiliated hospital of Soochow University
state: Jiangsu
city: Changchun
country: China
facility: The First Hospital of Jilin University
state: Jilin
city: Changchun
country: China
facility: Jilin Province People's Hospital
state: Jilin
city: Panjin
country: China
facility: Panjin Liaohe Oilfield Gem Flower Hospital
state: Liaoning
city: Yinchuan
country: China
facility: Yinchuan No.1 People's Hospital
state: Ningxia
city: Yinchuan
country: China
facility: General Hospital of Ningxia Medical University
state: Ningxia
city: Jinan
country: China
facility: Jinan Central Hospital
state: Shandong
city: XI 'an
country: China
facility: Shanxi Provincial People's Hospital
state: Shanxi
city: Xi'an
country: China
facility: The First Affiliated Hospital of Xi'an Jiaotong University
state: Shanxi
city: Xi'an
country: China
facility: Shaanxi Provincial People's Hospital
state: Shanxi
city: Chengdu
country: China
facility: West China Hospital Sichuan University
state: Sichuan
city: Chengdu
country: China
facility: SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos
state: Sichuan
city: Urumqi
country: China
facility: People's Hospital of Xinjiang Uygur Autonomous Region
state: Xinjiang
city: Urumqi
country: China
facility: The First Affiliated Hospital of Xinjiang Medical University
state: Xinjiang
city: Hangzhou
country: China
facility: 1st Affiliated Hospital of College Medicine, Zhejiang Univ.
state: Zhejiang
city: Beijing
country: China
facility: Beijing Anzhen Hospital, Capital Medical University
city: Beijing
country: China
facility: Beijing Friendship Hospital, Capital Medical University
city: Beijing
country: China
facility: Beijing Tsinghua Changgung Hospital
city: Shanghai
country: China
facility: Shanghai East Hospital Affiated to Tongji University
city: Shanghai
country: China
facility: Shanghai Tongji Hospital of Tongji University
city: Tianjin
country: China
facility: Tianjin People's Hospital
city: Medellin
country: Colombia
facility: Hospital General de Medellin
state: Antioquia
city: Medellin
country: Colombia
facility: Rodrigo Botero S.A.S
state: Antioquia
city: Medellín
country: Colombia
facility: Hospital Alma Mater de Antioquia
state: Antioquia
city: Rionegro
country: Colombia
facility: Sociedad Médica Rionegro SOMER S.A.
state: Antioquia
city: Baranquilla
country: Colombia
facility: Clínica de la Costa SAS
state: Atlántico
city: Barranquilla
country: Colombia
facility: IPS Centro Cientifico Asistencial S.A.S
state: Atlántico
city: Barranquilla
country: Colombia
facility: Corazón IPS S.A.S.
state: Atlántico
city: Bogota
country: Colombia
facility: Caja de Compensación Familiar CAFAM
state: Distrito Capital De Bogotá
city: Armenia
country: Colombia
facility: Fundación Cardiomet CEQUIN Eje Cafetero
state: Quindío
city: Bucaramanga
country: Colombia
facility: Instituto del Corazón de Bucaramanga
state: Santander
city: Ibague
country: Colombia
facility: Mediservis del Tolima IPS S.A.S
state: Tolima
city: Cali
country: Colombia
facility: Clínica Imbanaco S.A.S
state: Valle Del Cauca
city: Barranquilla
country: Colombia
facility: Fundacio del Caribe para la Investigacio Bio-Medica (BIOS)
city: Bogota
country: Colombia
facility: Fundación Cardioinfantil
city: Bogota
country: Colombia
facility: Hospital Universitario Clínica San Rafael
city: Medellin
country: Colombia
facility: Hospital San Vicente Fundación
city: Medellin
country: Colombia
facility: Clinica Cardio VID
city: Santa Fe De Bogotá
country: Colombia
facility: Hospital Universitario de San Ignacio
city: Brno
country: Czechia
facility: Kardiologie MUDr. Libor Nechvatal s.r.o.
city: Brno
country: Czechia
facility: Kardiologicka ambulance Brno s.r.o.
city: Brno
country: Czechia
facility: Fakultni nemocnice Brno
city: Cesky Krumlov
country: Czechia
facility: Kardiologicka ambulance
city: Chlumec nad Cidlinou
country: Czechia
facility: Kardio Chlumec s.r.o.- Kardiologicka ambulance
city: Dolni Brezany
country: Czechia
facility: Poliklinika Dolni Brezany
city: Hradec kralove
country: Czechia
facility: Fakultni Nemocnice Hradec Kralove
city: Kromeriz
country: Czechia
facility: LUNACOR, Centrum pro choroby srdce a cev
city: Kromeriz
country: Czechia
facility: Kromerizska nemocnice a.s.
city: Liberec
country: Czechia
facility: Krajska Nemocnice Liberec
city: Louny
country: Czechia
facility: KardioBusak s.r.o.
city: Pisek
country: Czechia
facility: Kardiologicka a interni ambulance
city: Plzen
country: Czechia
facility: Fakultni nemocnice Plzen
city: Podebrady
country: Czechia
facility: Polabska zdravotni, s.r.o.
city: Praha 11 - Chodov
country: Czechia
facility: Affidea Praha s.r.o
city: Praha 2
country: Czechia
facility: Vseobecna fakultni nemocnice v Praze
city: Praha 4
country: Czechia
facility: Institut Klinicke a Experimentalni Mediciny
city: Praha 5
country: Czechia
facility: Fakultni nemocnice v Motole
city: Praha 6
country: Czechia
facility: Ustredni vojenska nemocnice Praha
city: Trebic
country: Czechia
facility: Kardio s.r.o.
city: Trinec
country: Czechia
facility: Nemocnice Podlesi
city: Zlin
country: Czechia
facility: Angiocor s.r.o.
city: Znojmo
country: Czechia
facility: Nemocnice Znojmo
city: Aarhus N
country: Denmark
facility: Aarhus Universitetshospital, Skejby
city: Esbjerg
country: Denmark
facility: Sydvestjysk Sygehus Esbjerg | Kardiologisk Forskningsenhed
city: Hellerup
country: Denmark
facility: Capital Region | Gentofte Hospital - Cardiology Research
city: Herlev
country: Denmark
facility: Capital Region | Herlev Hospital - Department of Heart Disease
city: Herning
country: Denmark
facility: Region Midtjylland | Regionshospitalet Godstrup - Clinic for Heart Research
city: Holbæk
country: Denmark
facility: Holbæk Sygehus
city: Hvidovre
country: Denmark
facility: Hvidovre Hospital
city: Randers
country: Denmark
facility: Regionshospitalet Randers
city: Svendborg
country: Denmark
facility: Odense University Hospital | Svendborg Hospital - Cardiovascular Research Unit
city: Espoo
country: Finland
facility: HUS Jorvin sairaala
city: Tampere
country: Finland
facility: Tampereen yliopistollinen sairaala, keskussairaala
city: Turku
country: Finland
facility: Turun yliopistollinen keskussairaala
city: Ulm
country: Germany
facility: Herzklinik Ulm GbR
state: Baden-Württemberg
city: Würzburg
country: Germany
facility: Klinikum der Universität Würzburg
state: Bayern
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover (MHH)
state: Niedersachsen
city: Bielefeld
country: Germany
facility: Städt. Kliniken Bielefeld gGmbH
state: Nordrhein-Westfalen
city: Remscheid
country: Germany
facility: Sana-Klinikum Remscheid GmbH
state: Nordrhein-Westfalen
city: Witten
country: Germany
facility: Forschungszentrum Ruhr - KliFoCenter GmbH
state: Nordrhein-Westfalen
city: Kifisia / Athens
country: Greece
facility: KAT General Hospital of Athens
state: Attica
city: Alexandroupoli
country: Greece
facility: University General Hospital of Alexandroupolis
city: Ampelokipi - Athens
country: Greece
facility: General Hosp of Athens "Korgialenio-Benakeio" RCH
city: Athens
country: Greece
facility: HIPPOKRATION General Hospital of Athens
city: Athens
country: Greece
facility: G. GENNIMATAS General State Hospital of Athens
city: Athens
country: Greece
facility: General Hospital of Athens "ALEXANDRA"
city: Chaidari
country: Greece
facility: University General Hospital ATTIKON
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion
city: Larissa
country: Greece
facility: University General Hospital of Larissa
city: Nea Ionia / Athens
country: Greece
facility: Konstantopoulio General Hospital of Nea Ionia - AGIA OLGA
city: Patra
country: Greece
facility: University General Hospital of Patra
city: Thessaloniki
country: Greece
facility: Hippokration General Hospital of Thessaloniki
city: Shatin
country: Hong Kong
facility: Prince of Wales Hospital
state: N.T
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital
city: Kowloon
country: Hong Kong
facility: Queen Elizabeth Hospital Hong Kong
city: Lai Chi Kok
country: Hong Kong
facility: Princess Margaret Hospital
city: Balatonfured
country: Hungary
facility: Cardiomobile Egeszsegugyi Szolgaltato Kft.
city: Budapest
country: Hungary
facility: Budai Irgalmasrendi Korhaz
city: Budapest
country: Hungary
facility: University of Semmelweis/ Semmelweis Egyetem
city: Budapest
country: Hungary
facility: University of Semmelweis/ Semmelweis Egyetem
city: Budapest
country: Hungary
facility: Budapesti Uzsoki Utcai Korhaz
city: Budapest
country: Hungary
facility: Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet
city: Budapest
country: Hungary
facility: Eszak-Pesti Centrumkorhaz-Honvedkorhaz
city: Gyongyos
country: Hungary
facility: Bugat Pal Korhaz
city: Gyongyos
country: Hungary
facility: Pharma4Trial Kft.
city: Hodmezovasarhely
country: Hungary
facility: Csongrad-Csanad Varmegyei Egeszsegugyi Ellato Kozpont Hodmezovasarhelyi Tagintezmeny
city: Miskolc
country: Hungary
facility: Borsod-Abauj-Zemplen Varmegyei Korhaz es Egyetemi Oktatokorhaz
city: Nagykanizsa
country: Hungary
facility: Nagykanizsai Kanizsai Dorottya Korhaz
city: Nyiregyhaza
country: Hungary
facility: Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.
city: Pecs
country: Hungary
facility: Coromed Smo Kft
city: Pecs
country: Hungary
facility: Da Vinci Maganklinika
city: Szeged
country: Hungary
facility: SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont
city: Szekesfehervar
country: Hungary
facility: Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz
city: Szekszard
country: Hungary
facility: Tolna Varmegyei Balassa Janos Korhaz
city: Szentes
country: Hungary
facility: Csongrad-Csanad Megyei Dr. Bugyi Istvan Korhaz
city: New Delhi
country: India
facility: Max Super Speciality Hospital, Saket
state: Delhi
city: New Delhi
country: India
facility: Safdarjung Hospital
state: Delhi
city: Pune
country: India
facility: Deenanath Mangeshkar Hospital
state: Maharashtra
city: Pune
country: India
facility: KEM hospital
state: Maharashtra
city: Chennai
country: India
facility: Madras Medical Mission Institute
state: Tamil Nadu
city: Ashdod
country: Israel
facility: Assuta Ashdod
city: Ashkelon
country: Israel
facility: Barzilai Ashkelon University Medical Center | Cardiology Department
city: Haifa
country: Israel
facility: Rambam Health Corporation
city: Haifa
country: Israel
facility: Bnai Zion Medical Center | Cardiology Department
city: Haifa
country: Israel
facility: Lady Davis Carmel Medical Center
city: Jerusalem
country: Israel
facility: Hadassah Hebrew University Hospital Ein Kerem
city: Kfar Saba
country: Israel
facility: Meir Medical Center
city: Lower Galilee
country: Israel
facility: Poria Medical Center | Cardiovascular Department
city: Nahariya
country: Israel
facility: Health Corporation of Galilee Medical Center
city: Ramat Gan
country: Israel
facility: Chaim Sheba Medical Center
city: Rehovot
country: Israel
facility: Kaplan Medical Center
city: Tel Aviv
country: Israel
facility: Tel-Aviv Sourasky Medical Center
city: Zefat
country: Israel
facility: Health Corporation of the Ziv Medical Center (R.A.)
city: Zrifin
country: Israel
facility: Shamir Medical Center (Assaf Harofeh)
city: Catanzaro
country: Italy
facility: A.O.U. Mater Domini
state: Calabria
city: Napoli
country: Italy
facility: A.O.U. Policlinico Federico II Napoli
state: Campania
city: Bologna
country: Italy
facility: AUSL di Bologna
state: Emilia-Romagna
city: Bologna
country: Italy
facility: A.O.U. di Bologna Policlinico S.Orsola Malpighi
state: Emilia-Romagna
city: Ferrara
country: Italy
facility: A.O.U. di Ferrara
state: Emilia-Romagna
city: Piacenza
country: Italy
facility: AUSL di Piacenza
state: Emilia-Romagna
city: Bergamo
country: Italy
facility: ASST Papa Giovanni XXIII
state: Lombardia
city: Brescia
country: Italy
facility: ASST del Garda
state: Lombardia
city: Brescia
country: Italy
facility: ASST Spedali Civili di Brescia
state: Lombardia
city: Cremona
country: Italy
facility: ASST di Cremona
state: Lombardia
city: Milano
country: Italy
facility: Istituto Clinico Humanitas - Humanitas Mirasole S.p.A.
state: Lombardia
city: Milano
country: Italy
facility: IRCCS Centro Cardiologico Monzino
state: Lombardia
city: Milano
country: Italy
facility: IRCCS Istituti Clinici Scientifici Maugeri SpA SB
state: Lombardia
city: Monza Brianza
country: Italy
facility: ASST di Monza
state: Lombardia
city: Monza Brianza
country: Italy
facility: ASST della Brianza
state: Lombardia
city: Pavia
country: Italy
facility: Fondazione IRCCS Policlinico San Matteo
state: Lombardia
city: Varese
country: Italy
facility: ASST Sette Laghi
state: Lombardia
city: Novara
country: Italy
facility: A.O.U. Maggiore della Carità
state: Piemonte
city: Arezzo
country: Italy
facility: AUSL Toscana Sud-Est
state: Toscana
city: Siena
country: Italy
facility: A.O.U. Senese
state: Toscana
city: Perugia
country: Italy
facility: A.O. di Perugia
state: Umbria
city: Verona
country: Italy
facility: A.O.U.I. Verona
state: Veneto
city: Kasugai
country: Japan
facility: Kasugai Municipal Hospital
state: Aichi
city: Toyota
country: Japan
facility: TOYOTA Memorial Hospital
state: Aichi
city: Funabashi
country: Japan
facility: Funabashi Municipal Medical Center
state: Chiba
city: Kitakyushu
country: Japan
facility: Steel Memorial Yawata Hospital
state: Fukuoka
city: Onga-gun
country: Japan
facility: Onga Nakama Medical Association Onga Hospital
state: Fukuoka
city: Ogaki
country: Japan
facility: Ogaki Municipal Hospital
state: Gifu
city: Shobara
country: Japan
facility: Shobara Red Cross Hospital
state: Hiroshima
city: Himeji
country: Japan
facility: Hyogo Brain and Heart Center
state: Hyogo
city: Kobe
country: Japan
facility: National Hospital Organization Kobe Medical Center
state: Hyogo
city: Takarazuka
country: Japan
facility: Higashi Takarazuka Satoh Hospital
state: Hyogo
city: Toride
country: Japan
facility: JA Toride Medical Center
state: Ibaraki
city: Hakusan
country: Japan
facility: Public Central Hospital of Matto Ishikawa | Clinical Trial Management Office
state: Ishikawa
city: Kanazawa
country: Japan
facility: National Hospital Organization Kanazawa Medical Center | Clinical Trial Management Office
state: Ishikawa
city: Morioka
country: Japan
facility: Iwate Prefectural Central Hospital
state: Iwate
city: Kanonji
country: Japan
facility: Mitoyo General Hospital | Kagawa, Japan
state: Kagawa
city: Takamatsu
country: Japan
facility: Kagawa Prefectural Central Hospital
state: Kagawa
city: Sagamihara
country: Japan
facility: Kitasato University Hospital
state: Kanagawa
city: Sagamihara
country: Japan
facility: Sagamihara Kyodo Hospital
state: Kanagawa
city: Azumino
country: Japan
facility: Japan Red Cross Society Azumino Hospital
state: Nagano
city: Ueda
country: Japan
facility: National Hospital Organization Shinshu Ueda Medical Center
state: Nagano
city: Naha
country: Japan
facility: R.I.A.C Naha City Hospital
state: Okinawa
city: Kishiwada
country: Japan
facility: Kishiwada Tokushukai Hospital
state: Osaka
city: Takatsuki
country: Japan
facility: Takatsuki Red Cross Hospital
state: Osaka
city: Ageo
country: Japan
facility: Ageo Central General Hospital
state: Saitama
city: Kawaguchi
country: Japan
facility: Kawaguchi Cardiovascular and Respiratory Hospital
state: Saitama
city: Sayama
country: Japan
facility: Saitama Sekishinkai Hospital
state: Saitama
city: Hamada
country: Japan
facility: National Hospital Organization Hamada Medical Center
state: Shimane
city: Adachi-ku
country: Japan
facility: Nishiarai Heart Central Clinic
state: Tokyo
city: Hachioji
country: Japan
facility: Minamino Cardiovascular Hospital
state: Tokyo
city: Meguro-ku
country: Japan
facility: National Hospital Organization Tokyo Medical Center
state: Tokyo
city: Ota-ku
country: Japan
facility: Toho University Omori Medical Center
state: Tokyo
city: Yonago
country: Japan
facility: Japan Organization of Occupational Health and Safety Sanin Rosai Hospital
state: Tottori
city: Iwakuni
country: Japan
facility: National Hospital Organization Iwakuni Clinical Center
state: Yamaguchi
city: Shimonoseki
country: Japan
facility: JCHO Shimonoseki Medical Center
state: Yamaguchi
city: Fukuoka
country: Japan
facility: Fukuoka University Nishijin Hospital
city: Gifu
country: Japan
facility: Gifu Prefectural General Medical Center
city: Kumamoto
country: Japan
facility: National Hospital Organization Kumamoto Medical Center
city: Kumamoto
country: Japan
facility: Kumamoto University Hospital
city: Miyazaki
country: Japan
facility: Miyazaki Medical Association Hospital
city: Niigata
country: Japan
facility: Shinrakuen Hospital
city: Oita
country: Japan
facility: Oita Prefectural Hospital
city: Okayama
country: Japan
facility: The Sakakibara Heart Institute of Okayama
city: Osaka
country: Japan
facility: Osaka Police Hospital | Clinical Research and Trial Center
city: Osaka
country: Japan
facility: Osaka General Medical Center
city: Osaka
country: Japan
facility: Social Corporation Keigakukai Minamiosaka Hospital
city: Toyama
country: Japan
facility: Toyama University Hospital
city: Wakayama
country: Japan
facility: Seiyu Memorial Hospital
city: Cheongju-si
country: Korea, Republic of
facility: Chungbuk National University Hospital
state: Chungcheongbugdo
city: Wonju
country: Korea, Republic of
facility: Yonsei University Wonju Christian Hospital
state: Gang''weondo
city: Anyang
country: Korea, Republic of
facility: Hallym University Sacred Heart Hospital
state: Gyeonggido
city: Seongnam-si
country: Korea, Republic of
facility: Bundang Cha Hospital
state: Gyeonggido
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital
city: Daejeon
country: Korea, Republic of
facility: Chung Nam National University Hospital
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University Health System
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Daugavpils
country: Latvia
facility: Daugavpils Regional Hospital
city: Jelgava
country: Latvia
facility: Jelgava Outpatient Clinic
city: Liepaja
country: Latvia
facility: Liepaja Regional Hospital
city: Riga
country: Latvia
facility: 1st Riga Clinical Hospital
city: Riga
country: Latvia
facility: P. Stradins Clinical University Hospital
city: Riga
country: Latvia
facility: GK Neiroklinika
city: Ventspils
country: Latvia
facility: Gita Rancane - cardiology private practice
city: Alytus
country: Lithuania
facility: UAB "Klinikiniai sprendimai" Alytus
city: Kaunas
country: Lithuania
facility: LUHS Kauno Hospital (Laisves ave.)
city: Kaunas
country: Lithuania
facility: LUHS Kauno Hospital (Josvainiu str.)
city: Kaunas
country: Lithuania
facility: Saules family medicine center
city: Klaipeda
country: Lithuania
facility: Klaipedos Jurininku Ligonine
city: Siauliai
country: Lithuania
facility: Siauliai Republican hospital
city: Vilnius
country: Lithuania
facility: Vilnius University Hospital Santaros Klinikos
city: George Town,
country: Malaysia
facility: Gleneagles Penang Medical Center
city: Kuala Lumpur
country: Malaysia
facility: Institute Jantung Negara
city: Kuala Lumpur
country: Malaysia
facility: University Malaya Medical Centre
city: Perak
country: Malaysia
facility: Hospital Raja Permaisuri Bainun
city: Pulau Pinang
country: Malaysia
facility: Hospital Pulau Pinang
city: Sarawak
country: Malaysia
facility: Sarawak Heart Centre
city: Selangor
country: Malaysia
facility: Hospital Serdang
city: Torreón
country: Mexico
facility: Centro de Investigación Médica Dr. Alberto Bazzoni SA de CV
state: Coahuila
city: Alcaldia Gustavo A. Madero
country: Mexico
facility: Fundación de Atencion e Investigacion Medica Lindavista SC
state: Distrito Federal
city: Alcaldía Cuauhtemoc
country: Mexico
facility: Hospital de Jesús
state: Distrito Federal
city: Acapulco
country: Mexico
facility: Hospital General de Acapulco
state: Guerrero
city: Guadalajara
country: Mexico
facility: Consultorio de Medicina Especializada del Sector Privado
state: Jalisco
city: Queretaro
country: Mexico
facility: Centro de Estudios Clinicos de Queretaro S. C. (CECLIQ)
state: Querétaro
city: Xalapa
country: Mexico
facility: Hospital Ángeles de Xalapa
state: Veracruz
city: Aguascalientes
country: Mexico
facility: Hospital Cardiologica Aguascalientes
city: Durango
country: Mexico
facility: Centro de Investigacion y Atencion Integral Durango S.C.
city: Almelo
country: Netherlands
facility: Ziekenhuis Groep Twente
city: Blaricum
country: Netherlands
facility: Tergooiziekenhuizen-Blaricum
city: Deventer
country: Netherlands
facility: Deventer Ziekenhuis
city: Doetinchem
country: Netherlands
facility: Slingeland Ziekenhuis
city: Ede
country: Netherlands
facility: Ziekenhuis Gelderse Vallei
city: Eindhoven
country: Netherlands
facility: Catharina Ziekenhuis
city: Groningen
country: Netherlands
facility: Universitair Medisch Centrum Groningen
city: Harderwijk
country: Netherlands
facility: Ziekenhuis St. Jansdal
city: Maastricht
country: Netherlands
facility: Maastricht UMC
city: Meppel
country: Netherlands
facility: Isala Meppel
city: Sneek
country: Netherlands
facility: Antonius Ziekenhuis Sneek
city: Veldhoven
country: Netherlands
facility: Maxima Medisch Centrum, locatie Veldhoven
city: Auckland
country: New Zealand
facility: University of Auckland
city: Christchurch
country: New Zealand
facility: Christchurch Heart Institute
city: Dunedin
country: New Zealand
facility: Dunedin Hospital
city: Hawkes Bay
country: New Zealand
facility: P3 Research Ltd Hawkes Bay
city: Lower Hutt
country: New Zealand
facility: Hutt Hospital
city: Nelson
country: New Zealand
facility: Nelson Hospital
city: Tauranga
country: New Zealand
facility: P3 Research
city: Bialystok
country: Poland
facility: KLIMED Marek Klimkiewicz
city: Bydgoszcz
country: Poland
facility: MICS Centrum Medyczne Bydgoszcz
city: Gdynia
country: Poland
facility: Uniwersyteckie Centrum Medycyny Morskiej i Tropikalnej
city: Grodzisk Mazowiecki
country: Poland
facility: Samodzielny Publiczny Specjalistyczny Szpital Zachodni
city: Katowice
country: Poland
facility: CLINICAL MEDICAL RESEARCH Sp. z o. o.
city: Krakow
country: Poland
facility: Unicardia Specjalistyczne Centrum Leczenia Ch.Serca i Naczyn
city: Lublin
country: Poland
facility: IMEDICA Centrum Medyczne
city: Lublin
country: Poland
facility: NZOZ "Twoja Przychodnia" Sp. z o.o.
city: Olsztyn
country: Poland
facility: Zechowicz Medeusz-Plus Lekarska Spolka Partnerska
city: Oswiecim
country: Poland
facility: Oswiecimskie Centrum Badan Klinicznych Medicome Sp. z o.o.
city: Poznan
country: Poland
facility: Uniwersytecki Szpital Kliniczny w Poznaniu
city: Pulawy
country: Poland
facility: Szpital Specjalistyczny SPZOZ
city: Sopot
country: Poland
facility: NZOZ Pro-Cordis Sopockie Centrum Badan Kardiologicznych
city: Szczecin
country: Poland
facility: Twoja Przychodnia - Szczecinskie Centrum Medyczne
city: Torun
country: Poland
facility: Gessek Jacek Prywatny Gabinet Lekarski
city: Guimaraes
country: Portugal
facility: Hospital da Senhora da Oliveira | Clinical Research Department
state: Braga
city: Covilha
country: Portugal
facility: Centro Hospitalar Universitario Cova de Beira | Clinical Research Department
state: Castelo Branco
city: Matosinhos
country: Portugal
facility: ULSM - Hospital Pedro Hispano
state: Porto
city: Setubal
country: Portugal
facility: Hospital da Luz - Setubal
state: Setúbal
city: Amadora
country: Portugal
facility: Hospital Prof. Dr. Fernando Fonseca
city: Aveiro
country: Portugal
facility: BlueClinical | Centro Hospitalar Baixo Vouga - Unidade Aveiro - Gabinete de Ensaios Clinicos
city: Coimbra
country: Portugal
facility: Centro Hospitalar e Universitario de Coimbra, E.P.E. | Department of Cardiology, Research Unit
city: Guarda
country: Portugal
facility: ULSG - Unidade Local de Saude da Guarda
city: Leiria
country: Portugal
facility: Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center
city: Lisboa
country: Portugal
facility: Centro Hospitalar de Lisboa Ocidental | Clin Res Dept
city: Lisboa
country: Portugal
facility: Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica
city: Porto
country: Portugal
facility: Centro Hospitalar Universitario do Porto
city: Targu Mures
country: Romania
facility: CMI. Dr. Podoleanu Cristian
state: Mures
city: Timisoara
country: Romania
facility: Spitalul Clinic Municipal de Urgenta "Timisoara"
state: Timis
city: Baia Mare
country: Romania
facility: Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare
city: Braila
country: Romania
facility: Emergency County Hospital, Braila
city: Brasov
country: Romania
facility: S.C Thera Card S.R.L
city: Bucharest
country: Romania
facility: Emergency Institute for Cardiovascular Diseases
city: Bucharest
country: Romania
facility: Spitatul Universitar de Urgenta Bucaresti
city: Bucuresti
country: Romania
facility: Emergency Institute for Cardiovascular Diseases
city: Bucuresti
country: Romania
facility: Spitalul Clinic de Urgenta "Sf. Pantelimon"
city: Craiova Dolj
country: Romania
facility: Emergency Clinical County Hospital Craiova
city: Galati
country: Romania
facility: Sf. Ap. Andrei Emergency Clinical County Hospital Galati
city: Iasi
country: Romania
facility: S.C. CARDIOMED S.R.L. Iasi
city: Pitesti
country: Romania
facility: S.C. Sal Med SRL
city: Targu Mures
country: Romania
facility: S.C. Cardio Med S.R.L.
city: Timisoara
country: Romania
facility: Municipal Clinical Emergency Hospital of Timisoara
city: Timisoara
country: Romania
facility: Timisoara Institute of Cardiovascular Diseases
city: Aramil
country: Russian Federation
facility: SBHI of Sverdlovsk Region Aramil City Hospital
city: Arkhangelsk
country: Russian Federation
facility: First City Clinical Hospital n.a. E.E. Volosevich
city: Barnaul
country: Russian Federation
facility: Altai Regional Cardiological Dispensary
city: Chita
country: Russian Federation
facility: SBEI "Chita State Medical Academy"
city: Izhevsk
country: Russian Federation
facility: Izhevsk City Clinical Hospital #9
city: Kazan
country: Russian Federation
facility: Kazan Federal University
city: Kazan
country: Russian Federation
facility: Clinical Diagnostic Center
city: Kemerovo
country: Russian Federation
facility: Sci-Res. Institute of Complex Cardiovascular Disorders
city: Kirov
country: Russian Federation
facility: Center of cardiology and neurology
city: Moscow
country: Russian Federation
facility: Research center of therapy and prophylactic medicine
city: Moscow
country: Russian Federation
facility: City clinical hospital n.a. V.V. Vinogradov
city: Moscow
country: Russian Federation
facility: Moscow State University n.a. M.V. Lomonosov
city: Moscow
country: Russian Federation
facility: City Clinical Hospital #51
city: Moscow
country: Russian Federation
facility: Russian Clinical and Research Center of Gerontology
city: Novosibirsk
country: Russian Federation
facility: State Novosibirsk Regional Clinical Hospital
city: Omsk
country: Russian Federation
facility: Omsk Region "Clinical Health Unit No. 9"
city: Penza
country: Russian Federation
facility: Penza Regional Clinical Hospital n.a. N.N. Burdenko
city: Perm
country: Russian Federation
facility: Perm Regional Hospital for War Veterans
city: Rostov-on-Don
country: Russian Federation
facility: Rostov-on-Don Emergency Clinical Hospital
city: Ryazan
country: Russian Federation
facility: SBI of the Ryazan region "Regional clinical hospital"
city: Samara
country: Russian Federation
facility: Samara Regional Clinical Cardiology Dispensary n.a. Polyakov
city: Saratov
country: Russian Federation
facility: Clinical Hospital #3 n.a. S.R. Mirotvortsev
city: St. Petersburg
country: Russian Federation
facility: Scien. Res. Inst. of Emergency Care n.a. I.I. Dzhanelidze
city: St. Petersburg
country: Russian Federation
facility: St. Petersburg Clinical Hospital of RAS
city: St. Petersburg
country: Russian Federation
facility: LLC Astarta
city: Tomsk
country: Russian Federation
facility: Scientific Research Institute of Cardiology
city: Tomsk
country: Russian Federation
facility: Tomsk Regional Clinical Hospital
city: Yekaterinburg
country: Russian Federation
facility: Sverdlovsk Regional Clinical Hospital #1
city: Banska Bystrica
country: Slovakia
facility: Stredoslovensky ustav srdcovych a cievnych chorob, a.s.
city: Bardejov
country: Slovakia
facility: ALIAN s.r.o.
city: Bratislava 37
country: Slovakia
facility: Narodny ustav srdcovych a cievnych chorob, a.s
city: Bratislava
country: Slovakia
facility: Nemocnica svateho Michala, a.s.
city: Bratislava
country: Slovakia
facility: Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto
city: Bratislava
country: Slovakia
facility: Centrum interv. neuroradiologie a endovaskularnej liecby
city: Bratislava
country: Slovakia
facility: Kardiosanus | Bratislava, Slovakia
city: Brezno
country: Slovakia
facility: Nemocnica s poliklinikou Brezno, n.o.
city: Dolny Kubin
country: Slovakia
facility: Dolnooravska nemocnica s poliklinikou L. Nadasi Jegeho
city: Kosice
country: Slovakia
facility: JG-COR s.r.o.
city: Kosice
country: Slovakia
facility: Medical Group Kosice s.r.o. | Kosice, Slovakia
city: Levice
country: Slovakia
facility: KARDIO-ANGIO s.r.o.
city: Lucenec
country: Slovakia
facility: KardioMed s.r.o.
city: Moldava nad Bodvou
country: Slovakia
facility: MEDI M&M, s.r.o.
city: Nitra
country: Slovakia
facility: Kardiocentrum Nitra | Cardiology Clinic - Outpatient Department
city: Nove Zamky
country: Slovakia
facility: KARDIOMED NZ s.r.o.
city: Presov
country: Slovakia
facility: MEDISPOL s.r.o.
city: Sahy
country: Slovakia
facility: COR, s.r.o
city: Zilina
country: Slovakia
facility: Medivasa s.r.o.
city: Ferrol
country: Spain
facility: Complejo Hospitalario Universitario de Ferrol | Hospital Naval - Unidad de Hipertensión Arterial
state: A Coruña
city: San Bartolomé
country: Spain
facility: Hospital del Servei Valencià de Salud de la Vega Baja
state: Alicante
city: Oviedo
country: Spain
facility: Hospital Central de Asturias
state: Asturias
city: L'Hospitalet de Llobregat
country: Spain
facility: Hospital Universitari de Bellvitge | Bellvitge Biomedical Research Institute - Cardiology - AF, Stroke Prevention
state: Barcelona
city: El Puerto de Santa María
country: Spain
facility: Hospital Santa María del Puerto
state: Cádiz
city: Sanlucar de Barrameda
country: Spain
facility: Jose Manuel Pascual Pascual S.A. | Hospital Virgen del Camino - Internal Medicine Department
state: Cádiz
city: Villamartin
country: Spain
facility: Jose Manuel Pascual Pascual S.A. | Hospital Virgen de las Montanas - Internal Medicine Department
state: Cádiz
city: Las Palmas de Gran Canaria
country: Spain
facility: Hospital Dr. Negrín
state: Las Palmas
city: Malaga
country: Spain
facility: Hospital Universitario Virgen de la Victoria | Cardiology Department
state: Málaga
city: Utrera
country: Spain
facility: Hospital Alta Resolucion de Utrera | Cardiology Service Department
state: Sevilla
city: Barcelona
country: Spain
facility: Hospital del Mar
city: Barcelona
country: Spain
facility: Ciutat Sanitaria i Universitaria de la Vall d'Hebron
city: Granada
country: Spain
facility: Hospital Universitario Virgen de las Nieves|Cardiologia
city: Lleida
country: Spain
facility: Hospital Universitario Arnau de Vilanova de Lleida
city: Madrid
country: Spain
facility: Hospital Sanitas La Zarzuela | Cardiologia
city: Madrid
country: Spain
facility: Hospital Ramón y Cajal | Medicina Interna
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
city: Salvador
country: Spain
facility: Hospital San Rafael
city: Sevilla
country: Spain
facility: Complejo Hospitalario Ntra. Sra. de Valme
city: Valencia
country: Spain
facility: Hospital Clínico Universitario de Valencia
city: Valencia
country: Spain
facility: Hospital General Universitario de Valencia
city: Valencia
country: Spain
facility: La Fe University and Polytechnic Hospital | Cardiology Department
city: Valencia
country: Spain
facility: Hospital de Manises
city: Kaohsiung City
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
state: Kaohsiung
city: Changhua
country: Taiwan
facility: Changhua Christian Hospital
city: Hsinchu
country: Taiwan
facility: Mackay Memorial Hospital - Hsinchu Branch
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipei Medical University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Tao-Yuan
country: Taiwan
facility: Chang Gung Memorial Hospital at Linkou
city: Afyonkarahisar
country: Turkey
facility: Afyonkarahisar Saglik Bilimleri Universitesi
city: Antalya
country: Turkey
facility: Saglik Bilimleri Universitesi Antalya EA Hastanesi
city: Edirne
country: Turkey
facility: Trakya Univ. Tip Fak.
city: Eskisehir
country: Turkey
facility: Eskisehir Osmangazi Universitesi Tip Fakultesi
city: Istanbul
country: Turkey
facility: Istanbul Universitesi Cerrahpasa-Cerrahpasa Tip Fakultesi
city: Istanbul
country: Turkey
facility: Istanbul Universitesi Kardiyoloji Enstitusu
city: Istanbul
country: Turkey
facility: Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerrahisi E.A.H.
city: Izmir
country: Turkey
facility: Dokuz Eylul Universitesi Tip Fakultesi
city: Kayseri
country: Turkey
facility: Erciyes Universitesi Tip Fakultesi
city: Kocaeli
country: Turkey
facility: Kocaeli Universitesi Tip Fakultesi
city: Konya
country: Turkey
facility: Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi
city: Kutahya
country: Turkey
facility: Kutahya Saglik Bilimleri Uni. Evliya Celebi Egitim ve Arasti
city: Mersin
country: Turkey
facility: Mersin Universitesi Tip Fakultesi
city: Cherkasy
country: Ukraine
facility: Cherkasy Regional Cardiological Center
city: Dnipro
country: Ukraine
facility: "Clinical Emergency Hospital" of Dnipro City Council
city: Kharkiv
country: Ukraine
facility: National Institute of Therapy named after L.T.Maloyi
city: Kharkiv
country: Ukraine
facility: Regional Dispensary of Radiation Protection of Population
city: Kharkiv
country: Ukraine
facility: Miska Klinichna likarnya No 8
city: Kiev
country: Ukraine
facility: City Clinical Hospital # 1
city: Kiev
country: Ukraine
facility: Institute of Cardiology AMS
city: Kyiv
country: Ukraine
facility: Medbud-Clinic LLC
city: Kyiv
country: Ukraine
facility: Railway Clinical Hospital #2
city: Kyiv
country: Ukraine
facility: LLC Medical Centre CONSILIUM MEDICAL
city: Lviv
country: Ukraine
facility: Lviv regional clinical medical & diagnostic cardiology cente
city: Poltava
country: Ukraine
facility: Poltava Regional Clinical Hospital n.a. M.V. Skliphosovskyi
city: Uzhgorod
country: Ukraine
facility: Zakarpatsky Oblasnyi Kardiologichnyi Dyspanser
city: Vinnytsia
country: Ukraine
facility: Vinnytsia City Clinical Hospital #1
city: Vinnytsya
country: Ukraine
facility: Regional Clinical Hospital - Vinnytsya
city: Zaporizhzhja
country: Ukraine
facility: Regional medical center of cardio-vascular disease
city: Zaporizhzhya
country: Ukraine
facility: Zaporizhia Municipal Clinical Hospital No.10
city: Zaporizhzhya
country: Ukraine
facility: Zaporizhzhya City Emergency Care Hospital
city: Zhytomyr
country: Ukraine
facility: Communal Institution Central City Hospital 1 of Zhytomyr
city: Bournemouth
country: United Kingdom
facility: Royal Bournemouth General Hospital
state: Dorset
city: Poole
country: United Kingdom
facility: Poole Hospital NHS Trust
state: Dorset
city: Glasgow
country: United Kingdom
facility: Queen Elizabeth University Hospital
state: Glasgow City
city: Basingstoke
country: United Kingdom
facility: North Hampshire Hospital
state: Hampshire
city: Stevenage
country: United Kingdom
facility: Lister Hospital
state: Hertfordshire
city: Blackpool
country: United Kingdom
facility: Blackpool Victoria Hospital
state: Lancashire
city: Leicester
country: United Kingdom
facility: University Hospitals Leicester
state: Leicestershire
city: Ashington
country: United Kingdom
facility: Wansbeck General Hospital
state: Northumberland
city: Dudley
country: United Kingdom
facility: Russells Hall Hospital
state: West Midlands
city: Chichester
country: United Kingdom
facility: St Richard's Hospital
state: West Sussex
city: Cottingham
country: United Kingdom
facility: Castle Hill Hospital
city: Glasgow
country: United Kingdom
facility: Glasgow Royal Infirmary | Glasgow Clinical Research Facility
city: Manchester
country: United Kingdom
facility: Manchester Royal Infirmary
city: Swindon
country: United Kingdom
facility: Great Western Hospital
Study officials:
References: