Clinical trial NCT05645731: Lung Cancer Screening in Family Members and Peers of Lung Cancer Patients: a Prospective Cohort Study
Official title: Lung Cancer Screening in Family Members and Peers of Lung Cancer Patients: a Prospective Cohort Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Lung Cancer
Lung Cancer Screening
Patient Empowerment
Lead sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
Sponsor class: OTHER
First posted: 2022-12-09
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 1. Lung cancer patient recruited at clinics at the MUHC.
2. Close contacts of lung cancer patients referred to our study

Brief summary: Lung cancer screening of active or former heavy smokers with yearly low-dose CT allows for earlier diagnosis and better lung cancer survival. Risk of developing lung cancer is higher among family members and close contacts of lung cancer patients, because of shared genetics, environment and life habits like smoking. The investigators want to engage lung cancer patients to refer their family members and close contacts for lung cancer screening, and evaluate if this referred population have higher risk of lung cancer than the population referred by their family doctors.


Eligibility criteria: Lung cancer patients:

Inclusion Criteria:

* \> 18 years old
* Current or former lung cancer patient

Exclusion Criteria: none

Referred participants Inclusion criteria: \>18 years old Exclusion criteria: Personal history of lung cancer.

Primary outcomes:
measure: Mean number of referrals for lung cancer screening per participants
timeFrame: 2 weeks post inclusion
measure: Mean PLCOm2012 risk prediction model score among referred participants
timeFrame: baseline
Secondary outcomes:
measure: Number of visitors on our website for referred participants
timeFrame: 6 months
measure: Number of people who started to fill the enrollment form for referred participants.
timeFrame: 6 months
measure: Number of referred participants who enrolled in the study.
timeFrame: 6 months
measure: PLCO score as a binary outcome (above or below 2%) among referred participants
timeFrame: baseline
measure: Proportion of LCS eligible participants who will complete lung cancer screening within 18 months of referral by a lung cancer patient
timeFrame: 18 months
measure: Proportion of individuals who would theoretically demonstrate interest in genetic testing to assess for lung cancer risk.
timeFrame: baseline
measure: Proportion of individuals who demonstrate interest in referral to a smoking cessation program among referred participants that are current smokers
timeFrame: baseline
measure: Anxiety regarding lung cancer for referred participants
timeFrame: baseline
measure: Anxiety regarding lung cancer for referred participants
timeFrame: 1 month
Other outcomes:
Locations:
city: Montréal
country: Canada
facility: MUHC
state: Quebec
Study officials:
affiliation: Research Institute of the McGill University Health Center
name: Nicole Ezer, MD
role: PRINCIPAL_INVESTIGATOR
References: