Clinical trial NCT00549991: Analyzing Genes That May Increase the Risk of Developing High Blood Pressure
Official title: Fine Mapping of Hypertension Genes Detected by Admixture Mapping in the FBPP
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hypertension
Keywords: High Blood Pressure
Lead sponsor: Case Western Reserve University
Sponsor class: OTHER
Collaborators: name: National Heart, Lung, and Blood Institute (NHLBI)
First posted: 2007-10-26
Enrollment: 8687
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Previously collected genetic samples from African American participants in the Family Blood Pressure Program (FBPP) study and from African American, Mexican American, Nigerian, and Jamaican participants enrolled in other clinical studies will be examined.

Brief summary: High blood pressure is one of the most common health problems in the United States. Genetic variations may cause some people to be more susceptible to developing high blood pressure. This study will identify variations in genes known to play a part in the development of high blood pressure.

Detailed description: High blood pressure affects nearly one third of all individuals in the United States. It is especially common in African Americans, with more than 40% of African Americans diagnosed with this condition. High blood pressure usually develops earlier in life and is more severe in African Americans than in other racial or ethnic groups. Many factors can cause high blood pressure, including stress, diet, diabetes, kidney disease, or obesity. Previous studies have also shown that genetic variations on two regions of chromosomes 6 and 21 may predispose some people to develop high blood pressure. Admixture mapping is a type of genetic analysis that aims to identify disease-causing genetic variations across different populations of people. Using admixture mapping, this study will examine previously collected genetic samples from African American participants in the Family Blood Pressure Program (FBPP) study and from African American, Mexican American, Nigerian, and Jamaican participants enrolled in other clinical studies. Study researchers will analyze the samples to identify and characterize genetic variations that are associated with an increased risk of high blood pressure in the African American population, as well as other racial and ethnic groups.

Eligibility criteria: Inclusion Criteria:

* Participated in the FBPP study (African American \[800 people with high blood pressure and 800 control group participants\] and Mexican American participants)
* Participated in the American Family Study (African American participants)
* Participated in the Phenotyping Study (African American, Nigerian, and Jamaican participants)

Primary outcomes:
measure: Genetic variations
timeFrame: Measured through admixture mapping genetic analysis
Secondary outcomes:
Other outcomes:
Locations:
city: Cleveland
country: United States
facility: Case Western Reserve University
state: Ohio
Study officials:
affiliation: Case Western Reserve University
name: Xiaofeng Zhu, PhD
role: PRINCIPAL_INVESTIGATOR
References: