Clinical trial NCT01118429: Use of Oxybutynin to Treat Axillary Hyperhidrosis
Official title: Use of Oxybutynin to Treat Axillary Hyperhidrosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Axillary Hyperhidrosis
Osmidrosis
Keywords: hyperhidrosis
axillary
osmidrosis
oxybutynin
Lead sponsor: Grupo de Cirurgia Vascular
Sponsor class: OTHER
First posted: 2010-05-06
Enrollment: 100
Sex: ALL
Minimum age (years): 14
Maximum age (years): 55
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The objective of this study was to evaluate the effectiveness and patient satisfaction with the use of oxybutynin at low doses for treating axillary hyperhidrosis in a large series of patients.


Eligibility criteria: Inclusion Criteria:

* patients with axillary hyperhidrosis

Exclusion Criteria:

* glaucoma and micturition disorders, pregnancy

Primary outcomes:
measure: Effectiveness of treatment by a clinical questionnaire
timeFrame: 6 weeks of treatment
measure: Effectiveness of treatment using a clinical questionnaire
timeFrame: After 12 weeks of treatment
Secondary outcomes:
measure: Treatment of hyperhidrosis at other sites
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Sao Paulo
country: Brazil
facility: Hospital das Clinicas da FMUSP
Study officials:
affiliation: Hospital das Clinicas, University of Sao Paulo
name: Nelson Wolosker, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Wolosker N, Yazbek G, de Campos JR, Munia MA, Kauffman P, Jatene FB, Puech-Leao P. Quality of life before surgery is a predictive factor for satisfaction among patients undergoing sympathectomy to treat hyperhidrosis. J Vasc Surg. 2010 May;51(5):1190-4. doi: 10.1016/j.jvs.2009.11.078. Epub 2010 Mar 29.
citation: de Campos JR, Wolosker N, Yazbek G, Munia MA, Kauffman P, Puech-Leao P, Jatene FB. Comparison of pain severity following video-assisted thoracoscopic sympathectomy: electric versus harmonic scalpels. Interact Cardiovasc Thorac Surg. 2010 Jun;10(6):919-22. doi: 10.1510/icvts.2009.225383. Epub 2010 Mar 16.
citation: Yazbek G, Wolosker N, Kauffman P, Campos JR, Puech-Leao P, Jatene FB. Twenty months of evolution following sympathectomy on patients with palmar hyperhidrosis: sympathectomy at the T3 level is better than at the T2 level. Clinics (Sao Paulo). 2009;64(8):743-9. doi: 10.1590/S1807-59322009000800006.
citation: Munia MA, Wolosker N, Kaufmann P, de Campos JR, Puech-Leao P. Sustained benefit lasting one year from T4 instead of T3-T4 sympathectomy for isolated axillary hyperhidrosis. Clinics (Sao Paulo). 2008 Dec;63(6):771-4. doi: 10.1590/s1807-59322008000600011.
citation: Wolosker N, Yazbek G, Ishy A, de Campos JR, Kauffman P, Puech-Leao P. Is sympathectomy at T4 level better than at T3 level for treating palmar hyperhidrosis? J Laparoendosc Adv Surg Tech A. 2008 Feb;18(1):102-6. doi: 10.1089/lap.2007.0030.
citation: Munia MA, Wolosker N, Kauffman P, de Campos JR, Puech-Leao P. A randomized trial of T3-T4 versus T4 sympathectomy for isolated axillary hyperhidrosis. J Vasc Surg. 2007 Jan;45(1):130-3. doi: 10.1016/j.jvs.2006.09.011.