Clinical trial NCT01971762: Staphylococcus Aureus Bacteremia: Impact of an Intervention Program in Improving the Clinical Management and Review of the Clinical and Molecular Epidemiology
Official title: Staphylococcus Aureus Bacteremia: Impact of an Intervention Program in Improving the Clinical Management and Review of the Clinical and Molecular Epidemiology
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Staphylococcus Aureus Bacteremia
Keywords: multiresistant bacteremia
bacteremia management
blood culture
Lead sponsor: Andalusian Network for Design and Translation of Advanced Therapies
Sponsor class: OTHER
First posted: 2013-10-29
Enrollment: 600
Sex: ALL
Minimum age (years): 14
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients diagnosed bacteremia by S. aureus attended in participating centers will be included

Brief summary: Staphylococcus aureus bacteremia: impact of an intervention program in improving the clinical management and review of the clinical and molecular epidemiology.


Eligibility criteria: Inclusion Criteria:

* Patients over 14
* Clinical significant bacteremia by S. aureus
* Patient hospitalized

Exclusion Criteria:

* Non clinical significant bacteremia
* Ambulatory patient
* End-of-life patients

Primary outcomes:
measure: The overall target is to assess if the implementation of an active intervention program improves clinical management of the disease, according to existing recommendations.
timeFrame: 6 months
Secondary outcomes:
measure: Follow-up blood cultures performance of control blood culture 48-96h.
timeFrame: 6 months
measure: Early source control
timeFrame: 6 months
measure: Echocardiography in patients with clinical indications
timeFrame: 6 months
measure: Early use of IV cloxacillin for meticillin susceptible Staphylococcus aureus as definitive therapy
timeFrame: 6 months
measure: Adjustment of vancomycin dose according to trough levels.
timeFrame: 6 months
measure: Treatment duration according to the complexity of infection.
timeFrame: 6 Months
Other outcomes:
Locations:
city: Puerto Real
country: Spain
facility: Hospital de Puerto Real
state: Cádiz
city: Marbella
country: Spain
facility: Hospital Costa del Sol
state: Málaga
city: Almería
country: Spain
facility: Hospital de Torrecárdenas
city: Barcelona
country: Spain
facility: Hospital de barcelona - SCIAS
city: Bilbao
country: Spain
facility: Hospital de Cruces
city: Cádiz
country: Spain
facility: Hospital Puerta del Mar
city: Córdoba
country: Spain
facility: Hospital Reina Sofía
city: Granada
country: Spain
facility: Hospital Virgen de las Nieves
city: Huelva
country: Spain
facility: Hospital Juan Ramón Jiménez
city: Logroño
country: Spain
facility: Hospital de San Pedro
city: Murcia
country: Spain
facility: Hospital de la Arrixaca
city: Málaga
country: Spain
facility: Hospital Carlos Haya
city: Málaga
country: Spain
facility: Hospital Virgen de la Victoria
city: Santander
country: Spain
facility: Hospital de Valdecillas
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen de la Macarena
city: Sevilla
country: Spain
facility: Hospital Virgen de Valme
Study officials:
affiliation: Hospital Universitario Virgen Macarena
name: Jesús Rodríguez-Baño
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lopez-Cortes LE, Del Toro MD, Galvez-Acebal J, Bereciartua-Bastarrica E, Farinas MC, Sanz-Franco M, Natera C, Corzo JE, Lomas JM, Pasquau J, Del Arco A, Martinez MP, Romero A, Muniain MA, de Cueto M, Pascual A, Rodriguez-Bano J; REIPI/SAB group. Impact of an evidence-based bundle intervention in the quality-of-care management and outcome of Staphylococcus aureus bacteremia. Clin Infect Dis. 2013 Nov;57(9):1225-33. doi: 10.1093/cid/cit499. Epub 2013 Aug 8.