Clinical trial NCT07020091: Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest
Official title: Predictors of In-Hospital Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest: A Prospective Observational Study
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Post-Resuscitation Syndrome
Critical Illness
Cardiac Arrest
Hypoxic-Ischemic Encephalopathy
Coma
Keywords: Cardiac Arrest
ROSC
In-Hospital Mortality
ICU
Post-Resuscitation Care
Neurological Outcome
Lead sponsor: Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Sponsor class: OTHER
First posted: 2025-06-13
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients (≥18 years old) who achieved return of spontaneous circulation (ROSC) after cardiac arrest and were admitted to the intensive care unit (ICU) at Gazi Yaşargil Training and Research Hospital, Turkey. Patients are consecutively enrolled and observed for outcomes related to in-hospital and 6-month mortality.

Brief summary: This observational study aims to identify early predictors of in-hospital mortality in adult patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest. The study prospectively enrolls patients admitted to the intensive care unit at a tertiary care hospital in Turkey. Various clinical, biochemical, and resuscitation-related parameters will be recorded within the first 24 hours of ICU admission. The primary goal is to determine which factors are most strongly associated with mortality within 30 days. The findings are expected to improve clinical decision-making and risk stratification in the management of post-cardiac arrest patients.

Detailed description: This is a prospective observational study conducted in the intensive care unit (ICU) of Gazi Yaşargil Training and Research Hospital, Turkey. The study aims to identify independent predictors of in-hospital mortality in patients who achieve return of spontaneous circulation (ROSC) after cardiac arrest. Adult patients (age ≥ 18 years) who were resuscitated after cardiac arrest and admitted to the ICU are consecutively included.

Data are collected prospectively on admission and within the first 24 hours, including demographic characteristics, cause and type of arrest, time to ROSC, initial rhythm, hemodynamic parameters, neurological status, lactate, pH, base excess, biomarkers, and therapeutic interventions. Primary outcome is 30-day in-hospital mortality. Secondary outcomes include neurological outcome at discharge and ICU length of stay.

Patients are followed up until hospital discharge or death. The data will be analyzed using multivariate logistic regression to identify independent risk factors for mortality. The study was approved by the institutional ethics committee, and no intervention beyond routine care is performed. Results are expected to improve clinical prognostication and guide decision-making for patients with ROSC after cardiac arrest.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years
* Achieved return of spontaneous circulation (ROSC) after cardiac arrest
* Admitted to the intensive care unit (ICU)
* Informed consent obtained from patient or legal representative (if applicable)

Exclusion Criteria:

* Age \< 18 years
* Known pregnancy
* Brain death at the time of ICU admission
* Patients with missing key clinical or laboratory data
* Declined participation or legal refusal

Primary outcomes:
measure: In-Hospital Mortality
timeFrame: From ICU admission to hospital discharge (up to 60 days)
measure: 6-Month Mortality
timeFrame: 6 months after ICU admission
Secondary outcomes:
Other outcomes:
Locations:
city: Diyarbakır
country: Turkey
facility: Gazi Yaşargil Training and Research Hospital
state: Kayapinar
Study officials:
References: