Clinical trial NCT00703443: The Genetics of Cardiomyopathy and Heart Failure
Official title: The Genetics of Cardiomyopathy and Heart Failure
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy
Mitochondrial Cardiomyopathy
Noncompaction Cardiomyopathy
Restrictive Cardiomyopathy
Keywords: Genetics
Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy
Mitochondrial Cardiomyopathy
Noncompaction Cardiomyopathy
Restrictive Cardiomyopathy
Heart Failure
Lead sponsor: University of California, Irvine
Sponsor class: OTHER
First posted: 2008-06-23
Enrollment: 0
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: FAMILY_BASED
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: We are recruiting both local participants (who have been evaluated at UCI) and remote participants (who have been referred from outside UCI) with familial and simplex cases of hypertrophic, dilated, noncompaction, restrictive, and mitochondrial cardiomyopathies. As a control group, we are also recruiting patients with nuclear mutations known to increase the risk of cardiomyopathy, but who have not themselves developed cardiomyopathy.

Brief summary: The purpose of this study is to determine the genetic basis of cardiomyopathies and heart failure.

Detailed description: The purpose of this research study is to explore the causes and inheritances of cardiomyopathies. Cardiomyopathies are serious medical conditions that result in a wide range of cardiac problems, from no symptoms at all to heart failure. The underlying genetics of cardiomyopathies are poorly understood. This study will collect personal, family, and medical history information to create a database of participants with cardiomyopathies. This information will be used to identify inheritance patterns within families with cardiomyopathies. In addition, samples from participants will be studied in the lab to see if any changes in their genetic information can be identified that would cause a cardiomyopathy. Overall, the research study is aimed at determining the cause of these cardiac conditions so that tests and treatments might be developed in the future.

Eligibility criteria: Inclusion Criteria:

* Individuals with a diagnosis of cardiomyopathy
* Family members of individuals with a diagnosis of cardiomyopathy
* Individuals with a nuclear mutation shown to confer risk of cardiomyopathy but who do not themselves have cardiomyopathy

Exclusion Criteria:

* Individuals who do not have cardiomyopathy, a relative with cardiomyopathy, or a nuclear mutation predisposing to cardiomyopathy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Irvine
country: United States
facility: University of California, Irvine
state: California
Study officials:
affiliation: University of California, Irvine
name: Michael V Zaragoza, M.D., Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Zaragoza MV, Arbustini E, Narula J. Noncompaction of the left ventricle: primary cardiomyopathy with an elusive genetic etiology. Curr Opin Pediatr. 2007 Dec;19(6):619-27. doi: 10.1097/MOP.0b013e3282f1ecbc.