louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03716791: The Effect of Methylsulfonylmethane (MSM) on Cardiometabolic Health
Official title: The Effect of Methylsulfonylmethane (MSM) on Cardiometabolic Health
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Lead sponsor: Washington State University
Sponsor class: OTHER
First posted: 2018-10-23
Enrollment: 43
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Double-blind placebo controlled randomized controlled trial
Primary purpose: PREVENTION

Brief summary: Obesity- related diseases are linked to elevated levels of inflammation, oxidative stress, and metabolic dysfunction. Methylsulfonylmethane (MSM) is a naturally occurring compound that demonstrates antioxidant and anti-inflammatory effects. Improvements in measures of metabolic health have been observed in mouse models of obesity and type 2 diabetes following MSM treatment. However, the effect of MSM on obesity-related risk factors for disease in humans has not been investigated. Therefore, the purpose of this investigation will be to determine whether MSM supplementation improves metabolic health, and markers of inflammation and oxidative status.


Eligibility criteria: Inclusion Criteria:

* overweight or obese adults without any diagnosed disease or current medications other than birth control. Participants must agree to maintain diet and physical activity levels throughout study.

Exclusion Criteria:

* normal weight adults, or overweight/obese adults that do not meet the criteria for metabolically unhealthy obesity. Individuals currently on medications, or with diagnosed disease. Pregnant or nursing women, or women planning to become pregnant within the study timeframe. Lack of access to reliable transportation to study site, lack of internet access, or non-english speaking.

Primary outcomes:
measure: Change from baseline blood glucose at 4, 8, and 16 weeks
timeFrame: 0,4,8,16 weeks
measure: Change from baseline blood cholesterol at 4, 8, and 16 weeks
timeFrame: 0,4,8,16 weeks
measure: Change from baseline blood pressure at 4, 8, and 16 weeks
timeFrame: 0,4,8,16 weeks
Secondary outcomes:
measure: Change from baseline insulin at 4, 8, and 16 weeks
timeFrame: 0,4,8,16 weeks
measure: Change from baseline resting metabolic rate at 16 weeks
timeFrame: 0 and 16 weeks
measure: Change from baseline percent body fat at 4, 8, and 16 weeks
timeFrame: 0,4,8,16 weeks
measure: Change from baseline in waist circumference at 4, 8, and 16 weeks
timeFrame: 0,4,8,16 weeks
measure: Change from baseline in blood markers of inflammation and oxidative stress at 4, 8, and 16 weeks
timeFrame: 0,4,8,16 weeks
measure: Change from baseline in pulmonary function tests
timeFrame: 0, 4, 8, 16 weeks
Other outcomes:
Locations:
city: Spokane
country: United States
facility: Washington State University
state: Washington
Study officials:
affiliation: Washington State University
name: Lindsey E Miller, Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03916991: Effect of Hip-focused Neuromuscular Activation Exercise on Foot Posture and Neuromuscular Control
Official title: A Cross-over Study to Investigate the Effect of Hip-focused Neuromuscular Activation Exercise on Foot Posture and Neuromuscular Control
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Exercise
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2019-04-16
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: A cross-over study to investigate the effect of hip-focused neuromuscular activation exercise on foot posture and neuromuscular control
Primary purpose: TREATMENT

Brief summary: This study planned to investigate the effect of hip-focused neuromuscular activation exercise on foot posture and neuromuscular control in symptomatic and asymptomatic participants. We will follow a cross-over study design to compare the effect of hip focused neuromuscular activation exercise or a sham exercise on foot posture and lower extremity biomechanics. Foot posture will be assessed by Navicular Drop Test (NDT), and lower extremity neuromuscular control will be assessed with Star Excursion Y-Balance Test (SEBT-Y) and Frontal Plane Projection Angle (FPPA) during single leg squat before and after the experiments. The results of this study may provide scientific knowledge for a kinetic chain approach during functional foot rehabilitation.


Eligibility criteria: Inclusion Criteria:

* To be included, participants should be between the ages of 18 and 45 years.

Exclusion Criteria:

* Participants will be excluded from this study if they have a history of lower body trauma or surgery, or positive trendelenburg sign and slump test.

Primary outcomes:
measure: Navicular Drop Test
timeFrame: 1 year
Secondary outcomes:
measure: Star Excursion Y-Balance Test
timeFrame: 1 year
measure: Frontal Plane Projection Angle
timeFrame: 1 year
Other outcomes:
Locations:
Study officials:
affiliation: Hacettepe University
name: Elif Turgut, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01069380: Resting Metabolic Rate in Chronic Bed-Ridden Patients
Official title: Resting Metabolic Rate in Chronic Bed-Ridden Patients
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Chronic Disease
Keywords: resting metabolic rate
bed ridden, vegetative
low conscious
minimal conscious state
immobilized
resting energy expenditure
Lead sponsor: Reuth Rehabilitation Hospital
Sponsor class: OTHER
First posted: 2010-02-17
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: chronically bed ridden patients for at least 1 year, hospitaqlized in REUTH MEDICAL CENTER

Brief summary: Research objective: to measure resting metabolic rate (REE) in long term, bed ridden, chronically ill patients and to compare their measured energy needs to standard REE equations

Detailed description: Are standard REE equations suitable for estimating resting metabolic rate in long term, bed ridden, chronically ill patients?

Research objective: to measure resting metabolic rate (REE) in long term, bed ridden, chronically ill patients and to compare their measured energy needs to standard REE equations

Eligibility criteria: Inclusion Criteria:

* Age (years): 18-30, 31-60, 61-74, 75-100
* Confinement to bed at least for a year

Exclusion Criteria:

* Mechanical ventilation
* Tracheostomy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Tel Aviv
country: Israel
facility: Reuth Rehabilitation Hospital
Study officials:
affiliation: Reuth Rehabilitation Hospital
name: Avraham AL Lazary, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02282280: Clinical Use of Prilocaine Chlorhydrate Among a General Surgical Population
Official title: Clinical Use of Prilocaine Chlorhydrate Among a General Surgical Population
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anesthesia
Lead sponsor: Astes
Sponsor class: OTHER
First posted: 2014-11-04
Enrollment: 380
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 500 consecutive patients with a spinal anesthesia with prilocaine at Clinique Saint-Luc de Bouge

Brief summary: Observation of the effects of an administration of prilocaine chlorhydrate hyperbare in rachianesthesia among a general surgical population.


Eligibility criteria: Inclusion Criteria:

* 500 consecutive patients with a spinal anesthesia

Exclusion Criteria:

* Patient's refusal
* Age \< 18 years

Primary outcomes:
measure: Duration of action
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Namur
country: Belgium
facility: Clinique Saint-Luc Bouge
Study officials:
affiliation: Astes
name: Eric P Deflandre, MD, FCCP
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01338480: Improving Informed Consent Process for Trauma Patients in the Emergency Department
Official title: Improving Informed Consent Process for Trauma Patients in the Emergency Department
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Trauma
Surgery
Keywords: trauma
surgery
informed consent
Lead sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital
Sponsor class: OTHER
First posted: 2011-04-19
Enrollment: 172
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study is planning to develop the audiovisual videos and determine whether educational videos are superior to routine discussion for informing trauma patients in emergency department (ED) about risks, benefits, and alternatives to receiving surgery.


Eligibility criteria: Inclusion Criteria:

* 18 years of age or older
* scheduled to receive the surgery

Exclusion Criteria:

* clinically unstable
* refuse to participate
* unable to understand the consent process for this study

Primary outcomes:
measure: knowledge score
timeFrame: immediately after the intervention
Secondary outcomes:
measure: satisfaction
timeFrame: immediately after the intervention
Other outcomes:
Locations:
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
Study officials:
affiliation: Kaohsiung Medical University Chung-Ho Memorial Hospital
name: Yen-Ko Lin, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lin YK, Chen CW, Lee WC, Cheng YC, Lin TY, Lin CJ, Shi L, Tien YC, Kuo LC. Educational video-assisted versus conventional informed consent for trauma-related debridement surgery: a parallel group randomized controlled trial. BMC Med Ethics. 2018 Mar 9;19(1):23. doi: 10.1186/s12910-018-0264-7.
citation: Lin YK, Chen CW, Lee WC, Lin TY, Kuo LC, Lin CJ, Shi L, Tien YC, Cheng YC. Development and pilot testing of an informed consent video for patients with limb trauma prior to debridement surgery using a modified Delphi technique. BMC Med Ethics. 2017 Nov 29;18(1):67. doi: 10.1186/s12910-017-0228-3.
Clinical trial NCT05116280: MACE and PE in Elective Primary TKA & THA
Official title: Registration of the Major Adverse Cardiovascular Events and Pulmonary Embolism in Primary Total Joint Arthroplasty
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiovascular Complication
Pulmonary Embolism
Stroke
Transient Ischemic Attack
Death
Keywords: total joint arthroplasty
total hip arthroplasty
total knee arthroplasty
major adverse cardiovascular events
pulmonary embolism
Lead sponsor: University of Thessaly
Sponsor class: OTHER
First posted: 2021-11-11
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All consecutive patients age 18 years or older, with a diagnosis of primary osteoarthritis of the hip or knee, who underwent elective, primary, unilateral TKA or THA. Operations were performed by the 4 chief arthroplasty surgeons of the department.

Brief summary: This study ought to identify the occurence of the major adverse cardiovascular events (MACE) and the pumonary emoblism (PE) in patients undergoing elective primary THA \& TKA

Detailed description: The study included 220 consecutive patients undergoing elective primary THA \& TKA from January 2018 to December 2018. The occcurence of major adverse cardiovascular events (MACE) and the pumonary emoblism (PE) were recorder. Under the term MACE the following were included; non fatal cardiac arrest acute myocardial infraction congestive cardiac failure cardiac arrhythmia agnina stroke cardiovascular death cerebrovascular death

Eligibility criteria: Inclusion Criteria:

* All consecutive patients age 18 years or older, with a diagnosis of primary osteoarthritis of the hip or knee, who underwent elective, primary, unilateral TKA or THA.

Exclusion Criteria:

* previous TKA or THA within 3 months
* Revision surgery
* Surgical procedures related to a previous complication
* ASA PS IV
* recent history (6 months) of unstable acute coronary syndrome or decompensated heart failure

Primary outcomes:
measure: Major Adverse Cardiovascular Events
timeFrame: 1month postoperatively
measure: Pulmonary Embolism
timeFrame: 1month postoperatively
Secondary outcomes:
Other outcomes:
Locations:
city: Larissa
country: Greece
facility: University of Thessaly
Study officials:
References:
Clinical trial NCT00228280: Periapical Bone Healing After Apicectomy With and Without Retrograde Root Filling
Official title: Periapical Bone Healing After Apicectomy With and Without Retrograde Root Filling
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
PHASE2
Conditions: Stomatognathic Disease
Mouth Disease
Periapical Disease
Alveolar Bone Loss
Keywords: Apicoectomy
Retrograde
MTA
Lead sponsor: University of Aarhus
Sponsor class: OTHER
First posted: 2005-09-28
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Ph.D project: Periapical bone healing after apicectomy with and without retrograde root filling.

The aim of this study is to assess periapical bone healing after apicectomy without a filling and apicectomy combined with a retrograde filling material, MTA. Further, we will estimate risk factors in non-healing cases.

Study hypothesis: There is no difference in treatment outcome between:

Periapical bone healing after apicectomy with retrograde root filling and Periapical bone healing after apicectomy without retrograde root filling

Detailed description: Ph.D project: Periapical bone healing after apicectomy with and without retrograde root filling.

60 patients have been selected from a group of 490 patients, who had a full mouth radiographic status taken in connection with a population study of apical periodontitis in Aarhus Community. The selection criteria for the 60 patients were patients with a persisting apical periodontitis, Periapical Index (PAI) score 3-5, on front teeth and premolars in the upper jaw. The orthograde root filling in the tooth must be at least 2 years old and sufficient regarding density and length.

The 60 patients will be randomised into the two groups of apicectomy with and without filling. A radiograph will be taken just before the operation and 6 and 12 months after the operation. In the assessment of bone healing, we will use two different techniques, subtraction radiography and the Periapical Index (PAI).

We will also evaluate the benefits of using the operation microscope during the operation, and if clinical photos can be useful as documentation of treatment result.

Eligibility criteria: Inclusion Criteria:

healthy person age 18 or above sufficient root filling sufficient coronal restauration apical infection for at least 2 years Pai Score3, 4, or 5

Exclusion Criteria:

boneless more than 50 % communication between pocket and apical infection no visible root filling material after apicectomy facial bone less than 3 mm

Primary outcomes:
measure: Periapical bone healing Pai score
timeFrame: one-year
Secondary outcomes:
measure: Periapical bone healing bone density
timeFrame: one-year
Other outcomes:
Locations:
city: Aarhus
country: Denmark
facility: Faculty of Health Science
state: Aarhus C
Study officials:
affiliation: faculty of health science, royal dental collegue, department of Oral Radiology, Aarhus
name: Ann Wenzel, professor
role: STUDY_DIRECTOR
References:
Clinical trial NCT03690180: Hypomagnesemia and Diabetic Nephropathy
Official title: Hypomagnesemia as a Marker of Diabeteiv Nephropathy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Diabetic Nephropathies
Lead sponsor: Fayoum University
Sponsor class: OTHER
First posted: 2018-10-01
Enrollment: 100
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Diabetic patients following up in out patient clinic of diabetes and endocrine ,Fayoum university Hospital

Brief summary: To find if there is a corrolatation between Microalbuminurea and diabetic retinopathy, in daibetic patients

Detailed description: 40 Daibetic patients with microalbuminurea will be subjeted to full clinical examination and fundus examination,20 control diabetics with out microalbuminurea will also be included for comparison,patients will be selected from the outpatient clinic 0f fayoum university hospital.

Eligibility criteria: Inclusion Criteria:

* Diabetics on oral treatment,diabetics on insulin

Exclusion Criteria:

* Healthy volunteers,,hypertensive patients with normal blood glucose

Primary outcomes:
measure: Decrease in serum magnesium
timeFrame: One month
Secondary outcomes:
Other outcomes:
Locations:
city: Fayoum
country: Egypt
facility: Faculty of medicine Fayoum univesity
Study officials:
References:
Clinical trial NCT02209480: Alexander Technique Neck Pain
Official title: Randomized Controlled Trial on the Efficacy of F.M. Alexander Technique in Chronic Neck Pain Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Non-specific Neck Pain
Lead sponsor: Universität Duisburg-Essen
Sponsor class: OTHER
First posted: 2014-08-06
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aimed to test the efficacy of five Alexander Technique lessons compared to the same period of heat pad application and guided imagery in patients with chronic non-specific neck pain.

Detailed description: see above

Eligibility criteria: Inclusion Criteria:

* chronic non-specific neck pain
* at least 3 months
* 40mm pain intensity on visual analog scale

Exclusion Criteria:

* neck pain as consequence of disc protrusion or prolapse, whiplash, congenital deformity of the spine, spinal stenosis, neoplasm, inflammatory rheumatic disease, neurological disorder,
* active oncologic disease
* affective disorder
* addiction
* psychosis.
* pregnancy
* invasive treatment of the spine within the previous three weeks
* spinal surgery
* previous experiences in Alexander Technique
* ongoing application for disability pension
* simultaneous participation in other clinical trials on neck pain

Primary outcomes:
measure: neck pain intensity
timeFrame: 5 weeks
Secondary outcomes:
measure: quality of life
timeFrame: 5 weeks
measure: Pain on motion
timeFrame: 5 weeks
measure: Medication
timeFrame: 5 weeks
measure: functional disability
timeFrame: 5 weeks
measure: satisfaction
timeFrame: 5 weeks
measure: safety
timeFrame: 5 weeks
Other outcomes:
Locations:
city: Essen
country: Germany
facility: Department of Internal and Integrative Medicine, Kliniken Essen-Mitte
Study officials:
References:
citation: Lauche R, Schuth M, Schwickert M, Ludtke R, Musial F, Michalsen A, Dobos G, Choi KE. Efficacy of the Alexander Technique in treating chronic non-specific neck pain: a randomized controlled trial. Clin Rehabil. 2016 Mar;30(3):247-58. doi: 10.1177/0269215515578699. Epub 2015 Mar 31.
Clinical trial NCT05389280: Impact of Acute Kidney Injury on Sarcopenia and Frailty in Patients With Liver Cirrhosis
Official title: Impact of Acute Kidney Injury on Sarcopenia and Frailty in Patients With Liver Cirrhosis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cirrhosis
Kidney Injury
Sarcopenia
Frailty
Lead sponsor: Kangbuk Samsung Hospital
Sponsor class: OTHER
First posted: 2022-05-25
Enrollment: 80
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with liver cirrhosis and serum creatinine \<1.5 mg/dL

Brief summary: The aim of this prospective observational study is to evaluate the impact of acute kidney injury on sarcopenia and frailty in patients with liver cirrhosis.

Detailed description: The aim of this prospective study is to collect data on patients with liver cirrhosis and to investigate the impact of acute kidney injury on sarcopenia and frailty in patients with liver cirrhosis. If patients agree to participate in this clinical trial, the patients' data (such as age, sex, height, weight, nutrition status \[RFH-NPT\], history of medication, laboratory findings, endoscopic findings, and radiologic findings) will be collected in a research database. Renal injury was measured using conventional and novel serum biomarkers (serum creatinine, cystatin-C, neutrophil gelatinase-associated lipocalin, kidney injury molecule 1, and interleukin-18. Sarcopenia was evaluated using skeletal muscle index on abdominal computed tomography. Frailty was measured using Liver Frailty Index. The research database will be updated to include data on patients' disease outcomes and follow-up care.

Eligibility criteria: Inclusion Criteria:

* Liver cirrhosis
* aged over 20 years

Exclusion Criteria:

* serum creatinine \>1.5 mg/dL
* on dialysis
* liver transplant

Primary outcomes:
measure: Number of Participants with Acute kidney injury
timeFrame: up to 24 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Kangbuk Samsung Hospital
Study officials:
References:
Clinical trial NCT01474980: Pregnancy Outcomes in Congenital Myasthenie Syndrome
Official title: Retrospective Study :Describe the Changes of the Disease in Many Cases Likely to Aggravate.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Congenital Myasthenic Syndrome
Keywords: Congenital Myasthenic Syndrome
Pregnancy
Outcome
Lead sponsor: Institut de Myologie, France
Sponsor class: OTHER
Collaborators: name: Assistance Publique - Hôpitaux de Paris
First posted: 2011-11-18
Enrollment: 25
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women with Congenital Myasthenie Syndrome

Brief summary: This is a retrospective study that follows the clinical evolution, the pregnancy and the post-partum perioad of female patients with Congenital Myasthenic Syndrome.

Detailed description: The aim of this study is to better understand the action of hormonal factors that are presumably incriminated for the fluctuation of the disease. The investigators would also like to better adress the issues of women with Congenital Myasthenic Syndrome, who desire a pregnancy : the possibility of decompensation, the problems that can arise during the course of the childbearing, the risk of foetal malformations.

Eligibility criteria: Inclusion criteria:

* Adult women
* Congenital myastenic syndrome genetically confirmed or with clinical compatible and electrophysiological evidence
* Written consent

Exclusion Criteria:

* Neurological or general pathology occurs significantly with the initiation and conduct of a pregnancy.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: institut myologie
name: Laurent SERVAIS, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: