Clinical trial NCT05765474: Motor Learning for Upper Limb Hemiparesis After Stroke
Official title: Motor Learning for Individuals With Upper Limb Hemiparesis After Stroke
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Stroke
Hemiparesis
Keywords: Stroke
Hemiparesis
Rehabilitation
Motor Learning
Lead sponsor: Columbia University
Sponsor class: OTHER
First posted: 2023-03-13
Enrollment: 28
Sex: ALL
Minimum age (years): 40
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this research is to learn about practice conditions that may benefit stroke survivors when learning to use their more affected arm to perform a task. Participants will be randomized into two groups. Experimental and control groups will differ by one practice variable that will not be disclosed until completion of testing procedures. Participants will practice a motor task using both their more and less affected arms for two consecutive days. A Pre-Test will be administered on Day 1 before the training begins. Immediate Transfer of Learning will be administered on Day 2 after the completion of training. Delayed (24-hour) Retention and Transfer Tests will be administered on Day 3.

Detailed description: Stroke involves loss of blood flow to the brain and can cause impaired upper limb motor function, resulting in long term disability. Targeted motor learning interventions can improve skill acquisition and functional upper limb use after stroke. For example, repetitive practice of a motor task has been shown to improve motor learning outcomes. However, more research is currently needed to identify important active ingredients in complex motor learning interventions and determine the most effective approaches for improving upper limb recovery after stroke. The purpose of this study is to investigate the impact of a specific practice variable on motor learning for individuals with upper limb hemiparesis after stroke. This research will inform the development of future stroke rehabilitation interventions aimed at improving skill acquisition and motor learning.

Eligibility criteria: Inclusion Criteria:

* At least 6 months following stroke (ischemic or hemorrhagic)
* Upper limb weakness resulting from the stroke
* Able to follow 2-step commands
* Box and Block test score of 3-60
* Intact proprioception at the index finger of the weaker arm
* English speaking

Exclusion Criteria:

* Severe neglect (Score of 2 on extinction and inattention items of NIHSS)
* Arm pain that limits movement or loss of functional range of movement (contracture)
* Unable to give informed consent
* Received Botox within the past 3-months

Primary outcomes:
measure: 24-Hour Retention Test: Number of completed scoops (more affected arm)
timeFrame: Day 3
Secondary outcomes:
measure: Immediate Transfer Test: Number of transported cubes (more affected arm)
timeFrame: Day 2
measure: 24-Hour Transfer Test: Number of transported cubes (more affected arm)
timeFrame: Day 3
measure: Self-Efficacy Rating for Scooping Task
timeFrame: Day 2
measure: Rating of Mood
timeFrame: Day 2
measure: Interest/Enjoyment Subscale of the Intrinsic Motivation Inventory
timeFrame: Day 2
measure: Perceived Competence Subscale of the Intrinsic Motivation Inventory
timeFrame: Day 2
measure: Perceived Choice Subscale of the Intrinsic Motivation Inventory
timeFrame: Day 2
measure: Value Subscale of the Intrinsic Motivation Inventory
timeFrame: Day 2
measure: Effort Subscale of the Intrinsic Motivation Inventory
timeFrame: Day 2
measure: Pressure/Tension Subscale of the Intrinsic Motivation Inventory
timeFrame: Day 2
Other outcomes:
Locations:
city: New York
country: United States
facility: Columbia University Irving Medical Center
state: New York
Study officials:
affiliation: Columbia University
name: Dawn Nilsen, EdD
role: PRINCIPAL_INVESTIGATOR
References: