Clinical trial NCT06367894: Treatment Optimization and Nephrolithiasis Recurrence Prevention With Interdisciplinary Care
Official title: Study on Treatment Optimization and Nephrolithiasis Recurrence Prevention With Interdisciplinary Care
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Kidney Stone
Lead sponsor: Brugmann University Hospital
Sponsor class: OTHER
First posted: 2024-04-16
Enrollment: 164
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients of the CHU Brugmann Hospital who fulfill the criteria of active or past history of kidney stone, from 01/01/2018 till 31/10/2023

Brief summary: Nearly 10% of the Belgian population suffer from kidney stone disease. Recent reviews reported that kidney stones represent an underestimated risk factor for further kidney function deterioration. Preventive measures are recommended in lithiases patients to prevent the formation of new stones. The individual effects of different medicated prosthetic interventions have been documented in clinical trials. However, there is little data on the effectiveness of combining these different preventive measures in routine clinical practice (real-world context).

Patients with kidney stone disease require a complete metabolic assessment. The three main factors contributing to the stone's formation are the patient's metabolism, diet and lifestyle. Metabolic work-up is recommended by the American Urology Association to identify and correct the factors responsible for urinary stone formation such as hypercalciuria, hyperoxaluria, hyperuricuria, hypocitraturia or abnormalities of urinary pH. The metabolic work-up includes at minimum the 24h urine test, a blood test and spot urine test. Dietary habits and lifestyle are assessed by means of a questionnaire.

The CHU Brugmann Hospital has a specialized multidisciplinary clinic for renal lithiases and mineral metabolism. Preventive personalized and interdisciplinary care in CHU Brugmann consists of a full metabolic work-up allowing the identification of lithogenic risk factors by nephrologists, dietary assessment by specialized dieticians and specific treatment protocol associated with regular follow-up.

The aim of this study is to evaluate, in the context of a retrospective single-center cohort study, the effect of preventive personalized and interdisciplinary care on the evolution of all urinary lithogenic risk factors and the recurrence of kidney stones (rate of renal colics, emergency room admissions, and urological interventions).


Eligibility criteria: Inclusion Criteria:

* All patients of the CHU Brugmann Hospital who fulfill the criteria of active or past history of kidney stone, from 01/01/2018 till 31/10/2023
* Minimum follow-up time of 2 months with biochemical and clinical results available

Exclusion Criteria:

- None

Primary outcomes:
measure: Number of acute renal colics
timeFrame: From first patient consultation till 31/10/2023
measure: Number of emergency admissions
timeFrame: From first patient consultation till 31/10/2023
measure: Number of surgeries
timeFrame: From first patient consultation till 31/10/2023
measure: Number of hospitalizations
timeFrame: From first patient consultation till 31/10/2023
measure: Identified genetics abnormalities
timeFrame: From first patient consultation till 31/10/2023
measure: Wisconsin questionnaire
timeFrame: From first patient consultation till 31/10/2023
measure: Kidney function outcome
timeFrame: Status at 31/10/2023
Secondary outcomes:
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: CHU Brugmann
Study officials:
References: