Clinical trial NCT05129826: The Association Between Periodontal Disease and Malnutrition in a Group of Elderly People in Thailand.
Official title: The Association Between Periodontal Disease and Malnutrition in a Group of Elderly People in Thailand.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Periodontal Diseases
Malnutrition
Keywords: periodontal disease
malnutrition
older adult
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2021-11-22
Enrollment: 78
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Subjects who has aged ≥ 60 years old, not receive periodontal treatment within the previous 6 months, able to read Thai and express verbal communication, functional independent older adults (get ≥ 12 points from Barthel Index for Activities of Daily Living) and cognitive functional independent older adults (get \> 23 points from Thai Mental State Examination).
Primary purpose: SCREENING

Brief summary: This study will be determine the association between periodontitis and malnutrition status in older adult.

Detailed description: Ageing may accompany with an accumulation of diseases and impairments cause by physiological, socioeconomic and psychological changes. The older adults are more prone to nutritional deficiencies due to combination of factors such as ageing, excessive polypharmacy, general health decline, poor socioeconomic status, cognitive decline, poor appetite, impaired efficacy of swallowing and limit eating ability.

Periodontitis is a multifactorial disease predominantly a bacterial infection involving the dental biofilm or dental plaque. Periodontitis increases in extent and severity across a large proportion of the human population with ageing. The effects of ageing on the immune system include distinct alterations in both innate and adaptive immune-cell function and effector biomolecules, resulting in processes reflecting immunosenescence, immunoactivation and inflammaging. Moreover, genetic contribution alters immunity and inflammation that play a role in the dysregulation of host responses in ageing. The combination of chronic antigenic burden and uncontrolled inflammatory response can enhance immunosenescence and ageing-associated disease. Periodontitis also has an effect on food intake, nutritional status and quality of life in older adults.

However the relationship between chronic periodontitis and malnutrition in older adult is not clear and needs further study. In this study will be determine the association between periodontitis and malnutrition status in older adult.

Eligibility criteria: Inclusion Criteria:

1. Subjects who has aged ≥ 60 years old.
2. Subjects who not receive periodontal treatment within the previous 6 months.
3. Subjects who are able to read Thai and express verbal communication.
4. Subjects who are functional independent older adults (get ≥ 12 points from Barthel Index for Activities of Daily Living) \[50, 51\].
5. Subjects who are cognitive functional independent older adults (get \> 23 points from Thai Mental State Examination) \[52\].

Exclusion Criteria:

1. Subjects with completely edentulous area.
2. Subjects who require antibiotic prophylaxis for dental examination

Primary outcomes:
measure: Nutritional status
timeFrame: 1 hour
measure: Periodontal status
timeFrame: 2 hour
Secondary outcomes:
measure: Variables that associated with malnutrition in older adult.
timeFrame: 1 month
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Kanyawat Rattanasuwan
Study officials:
affiliation: Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mahidol University.
name: Kanyawat Rattanasuwan
role: PRINCIPAL_INVESTIGATOR
References: