Clinical trial NCT04880057: Agility Training on Executive Function, Dual Task Performance and Brain Activation in Healthy Adults
Official title: Effects of Agility Training on Executive Function, Dual Task Performance and Brain Activation in Healthy Adults
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Agility Training
Executive Function
Keywords: brain activity
motor performance
dual task walking
executive function
agility training
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2021-05-10
Enrollment: 70
Sex: ALL
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will investigate the effect of agility training on executive function, dual task walking and brain activation in healthy adults. Participants (N=70) will be randomly assigned to resistance+aerobic training group (RAeT) or agility training group (AT). Participants in RAeT (n=35) will receive 15-minute lower extremity workout first and then 25-minute moderate intensity (60-75% predicted maximal heart rate) aerobic training. Participants in AT (n=35) will do the agility exercise program consisting of technical drills, pattern running and reactive agility training. The intervention will be twelve-time group intervention (3-5persons) in four weeks, 50 minutes per session (5-minute warmup, 40- minute main training, 5-minute cool-down). Participants will undergo three measurement time points (pre-, post-intervention and one month follow-up). Outcome measures will include executive function (N-back test, stroop test and Wisconsin card sort test), single and dual task walking performance and brain activity (fNIRS on prefrontal cortex, supplementary motor area and premotor cortex). Two-way analysis of variance (ANOVA) with Tukey post-hoc test will be used to examine the group x time interaction on three outcome measures.


Eligibility criteria: Inclusion Criteria:

* (1) age between 20 to 30 years, and (2) ability to walk 20 meters independently without an assistive device.

Exclusion Criteria:

* (1) overweight (BMI\>24), (2) any smoker or alcohol abusers, (3) suffering from chronic diseases that loss of control, (4) Unstable physiological conditions, such as abnormal signs like high blood pressure, headache, dyspnea, fever, etc., (5) any neuromuscular or cardiopulmonary diseases that would influent the exercise performance, and (6) suffering from diseases which exercises are their contraindications

Primary outcomes:
measure: Executive function- N-back task (3-back)
timeFrame: Change from Baseline score at 3 weeks
measure: Executive function- N-back task (3-back)
timeFrame: Change from Baseline score at 7 weeks
measure: Executive function- Stroop test
timeFrame: Change from Baseline score at 3 weeks
measure: Executive function- Stroop test
timeFrame: Change from Baseline score at 7 weeks
measure: Executive function- Wisconsin card sort test
timeFrame: Change from Baseline score at 3 weeks
measure: Executive function- Wisconsin card sort test
timeFrame: Change from Baseline score at 7 weeks
measure: Single walking performance- Walking speed
timeFrame: Change from Baseline cadence at 3 weeks
measure: Single walking performance- Walking speed
timeFrame: Change from Baseline cadence at 7 weeks
measure: Single walking performance- Cadence
timeFrame: Change from Baseline cadence at 3 weeks
measure: Single walking performance- Cadence
timeFrame: Change from Baseline cadence at 7 weeks
measure: Single walking performance- Stride length
timeFrame: Change from Baseline cadence at 3 weeks
measure: Single walking performance- Stride length
timeFrame: Change from Baseline cadence at 7 weeks
measure: Single walking performance- Step duration
timeFrame: Change from Baseline cadence at 3 weeks
measure: Single walking performance- Step duration
timeFrame: Change from Baseline cadence at 7 weeks
measure: Dual task walking performance- Walking speed
timeFrame: Change from Baseline cadence at 3 weeks
measure: Dual task walking performance- Walking speed
timeFrame: Change from Baseline cadence at 7 weeks
measure: Dual task walking performance- Cadence
timeFrame: Change from Baseline cadence at 3 weeks
measure: Dual task walking performance- Cadence
timeFrame: Change from Baseline cadence at 7 weeks
measure: Dual task walking performance- Stride length
timeFrame: Change from Baseline cadence at 3 weeks
measure: Dual task walking performance- Stride length
timeFrame: Change from Baseline cadence at 7 weeks
measure: Dual task walking performance- Step duration
timeFrame: Change from Baseline cadence at 3 weeks
measure: Dual task walking performance- Step duration
timeFrame: Change from Baseline cadence at 7 weeks
measure: Dual task walking performance- the correct rates of arithmetic task
timeFrame: Change from Baseline cadence at 3 weeks
measure: Dual task walking performance- the correct rates of arithmetic task
timeFrame: Change from Baseline cadence at 7 weeks
Secondary outcomes:
measure: Brain activities over premotor cortex- Executive function
timeFrame: Change from Baseline at 3 weeks
measure: Brain activities over premotor cortex- Executive function
timeFrame: Change from Baseline at 7 weeks
measure: Brain activities over supplementary motor area- Executive function
timeFrame: Change from Baseline at 3 weeks
measure: Brain activities over supplementary motor area- Executive function
timeFrame: Change from Baseline at 7 weeks
measure: Brain activities over primary motor cortex- Executive function
timeFrame: Change from Baseline at 3 weeks
measure: Brain activities over primary motor cortex- Executive function
timeFrame: Change from Baseline at 7 weeks
measure: Brain activities over premotor cortex- Single walking
timeFrame: Change from Baseline at 3 weeks
measure: Brain activities over premotor cortex- Single walking
timeFrame: Change from Baseline at 7 weeks
measure: Brain activities over supplementary motor area- Single walking
timeFrame: Change from Baseline at 3 weeks
measure: Brain activities over supplementary motor area- Single walking
timeFrame: Change from Baseline at 7 weeks
measure: Brain activities over primary motor cortex - Single walking
timeFrame: Change from Baseline at 3 weeks
measure: Brain activities over primary motor cortex - Single walking
timeFrame: Change from Baseline at 7 weeks
measure: Brain activities over premotor cortex- Dual task walking
timeFrame: Change from Baseline at 3 weeks
measure: Brain activities over premotor cortex- Dual task walking
timeFrame: Change from Baseline at 7 weeks
measure: Brain activities over supplementary motor area- Dual task walking
timeFrame: Change from Baseline at 3 weeks
measure: Brain activities over supplementary motor area- Dual task walking
timeFrame: Change from Baseline at 7 weeks
measure: Brain activities over primary motor cortex - Dual task walking
timeFrame: Change from Baseline at 3 weeks
measure: Brain activities over primary motor cortex - Dual task walking
timeFrame: Change from Baseline at 7 weeks
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
References: