Clinical trial NCT00383474: Tipifarnib and Bortezomib in Treating Patients With Acute Leukemia or Chronic Myelogenous Leukemia in Blast Phase
Official title: A Phase I Dose-Escalation Study of R115777 (Tipifarnib) Plus PS-341 (Bortezomib) in Relapsed or Refractory Acute Leukemias
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Adult Acute Basophilic Leukemia
Adult Acute Eosinophilic Leukemia
Adult Acute Megakaryoblastic Leukemia
Adult Acute Monoblastic Leukemia
Adult Acute Monocytic Leukemia
Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11
Adult Acute Myeloid Leukemia With Maturation
Adult Acute Myeloid Leukemia With Minimal Differentiation
Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11
Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1
Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL
Adult Acute Myeloid Leukemia Without Maturation
Adult Acute Myelomonocytic Leukemia
Adult Erythroleukemia
Adult Pure Erythroid Leukemia
Blastic Phase
Recurrent Adult Acute Lymphoblastic Leukemia
Recurrent Adult Acute Myeloid Leukemia
Recurrent Disease
Untreated Adult Acute Lymphoblastic Leukemia
Untreated Adult Acute Myeloid Leukemia
Lead sponsor: National Cancer Institute (NCI)
Sponsor class: NIH
First posted: 2006-10-03
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This phase I trial is studying the side effects and best dose of tipifarnib and bortezomib in treating patients with acute leukemia or chronic myelogenous leukemia in blast phase. Tipifarnib and bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving tipifarnib together with bortezomib may kill more cancer cells.

Detailed description: PRIMARY OBJECTIVE:

I. Determine the dose-limiting toxicity and maximum tolerated dose of tipifarnib and bortezomib in patients with relapsed or refractory acute myeloid leukemia, acute lymphoblastic leukemia, or chronic myeloid leukemia in blast phase.

SECONDARY OBJECTIVES:

I. Determine the effect of this regimen on farnesyltransferase and proteasome inhibition in peripheral blood mononuclear cells in these patients.

II. Determine the clinical efficacy of this regimen in these patients.

OUTLINE: This is a dose-escalation study.

Patients receive bortezomib IV over 3-5 seconds on days 1, 4, 8, and 11 and oral tipifarnib twice daily on days 1-14. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients with partial response or stable disease may continue therapy beyond 6 courses at the discretion of the investigator.

Cohorts of 3-6 patients receive escalating doses of bortezomib and tipifarnib until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.

Blood is collected periodically for protein expression studies. Bone marrow aspirates obtained at baseline are examined by immunohistochemistry for Ki-67 activity.

Eligibility criteria: Inclusion Criteria:

* Meets 1 of the following disease-specific criteria:

  * Relapsed disease after =\< 2 prior chemotherapy regimens (consolidation therapy excluded)
  * Primary-induction failure
  * Previously untreated and deemed unfit for or refusing cytotoxic chemotherapy
* No hyperleukocytosis (leukemic blasts \>= 30,000/mm\^3)
* No acute promyelocytic leukemia (M3)
* No active CNS leukemia
* SGOT and SGPT =\< 2 times upper limit of normal (ULN)
* Bilirubin normal
* Creatinine =\< 1.5 times ULN
* No uncontrolled hypertension, congestive heart failure, angina pectoris, or ventricular dysrhythmias
* Not pregnant or nursing
* Negative pregnancy test
* No uncontrolled disseminated intravascular coagulation
* Fertile patients must use effective contraception

  * Hormonal contraception must have been initiated ≥ 1 month prior to study entry
* No active graft-vs-host disease
* No active uncontrolled infection
* No intrinsic impaired organ function
* No known allergy to imidazole drugs
* No neuropathy \>= grade 1
* No known hypersensitivity to bortezomib, tipifarnib, boron, or mannitol
* No physical or psychiatric conditions that would preclude study participation, including poorly controlled psychosis
* At least 48 hours since prior hydroxyurea
* No prior tipifarnib, bortezomib, or investigational proteasomal inhibitors
* No concurrent radiotherapy, chemotherapy, or immunotherapy
* No concurrent enzyme-inducing antiepileptic medications (e.g., phenytoin, phenobarbital, or carbamazepine)
* ECOG performance status 0-2
* LVEF \>= 40%
* Pathologically confirmed diagnosis of 1 of the following:

  * Acute myeloid leukemia
  * Acute lymphoblastic leukemia
  * Chronic myelogenous leukemia in blast phase

Primary outcomes:
measure: Dose-limiting toxicity and maximum tolerated dose of tipifarnib and bortezomib
timeFrame: 21 days
Secondary outcomes:
measure: Changes in apoptotic protein expression (Bim, Bax, AKT)
timeFrame: Baseline and day 8
measure: Clinical efficacy (response rate) evaluated using the revised International Working Group Criteria (IWG) for AML
timeFrame: Up to 3 years
measure: Farnesytransferase and proteasome inhibition in peripheral blood mononuclear cells
timeFrame: Day 8
measure: Farnesytransferase and proteasome inhibition in peripheral blood mononuclear cells
timeFrame: Day 15
Other outcomes:
Locations:
city: Tampa
country: United States
facility: Moffitt Cancer Center
state: Florida
Study officials:
affiliation: Moffitt Cancer Center
name: Jeffrey Lancet
role: PRINCIPAL_INVESTIGATOR
References: