louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05787080: Massage, Oxidative and Antioxidant Enzymes in Hemodialysis Patients With Restless Legs Syndrome(RLS)
Official title: The Effect of Massage on Oxidative and Antioxidant Enzymes in Hemodialysis Patients With Restless Legs Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Renal Failure Chronic
Restless Legs Syndrome
Keywords: renal failure
Lead sponsor: Baskent University
Sponsor class: OTHER
First posted: 2023-03-28
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Massage/experimental Group- control Group
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study; It will be done to evaluate the presence of oxidative stress and its effects on lipid peroxidation products and antioxidant parameters after massage application and the possible effects of the appropriate massage protocol applied to the patients on oxidative stress in hemodialysis patients with restless legs syndrome.

Detailed description: In this study, the following research hypotheses will be tested. H0a: Individuals with restless legs syndrome receiving hemodialysis treatment; In the second hour of hemodialysis, massage applied to both calf muscles for 10 minutes three times a week for one month is not affect the oxidative and antioxidant enzymes of the patients.

H1a: Individuals with restless legs syndrome receiving hemodialysis treatment; In the second hour of hemodialysis, massage applied to both calf muscles for 10 minutes three times a week for one month is effective on the oxidative and antioxidant enzymes of the patients.

Eligibility criteria: Inclusion Criteria:

1. Receiving hemodialysis treatment for at least 6 months, 3 days a week for 4 hours,
2. Patients with RLS according to the diagnostic criteria of the International RLS study group,
3. No psychiatric problems,
4. No neurological deficit,
5. Exercise and physical therapy modalities have not been applied in the last year,
6. In the laboratory examinations, the kinetic indicators of dialysis adequacy are within the desired target range (Kt/V: 1.2-1.3; URR: 60-65%), and there are no pathological findings (fracture, dislocation, tumor, infection) in the radiological examinations. .

Exclusion Criteria:

1. Hemiplegic patients
2. Patients with heart failure
3. Individuals with chronic obstructive pulmonary diseases

Primary outcomes:
measure: Malondialdehyde (MDA) levels of RLS patients
timeFrame: 1 week
measure: Erythrocyte Reducte Glutathione (GSH) levels of RLS patients
timeFrame: 1 week
Secondary outcomes:
measure: Effect of vibration massage on blood level of Malondialdehyde
timeFrame: 1 week
measure: Effect of vibration massage on blood level of Erythrocyte Reducte Glutathione
timeFrame: 1 week
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Baskent University
state: Türkiye
Study officials:
References:
Clinical trial NCT00375180: Nutritional Status and Barriers to Dietary Intake in Head and Neck Cancer Patients
Official title: Nutritional Status and Barriers to Dietary Intake in Head and Neck Cancer Patients Prior to, on Completion of and Six Weeks After Oncology Treatment
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Head and Neck Cancer
Keywords: food
diet
mucositis
xerostomia
dysphagia
taste
smell
head and neck
radiation
chemotherapy
Lead sponsor: AHS Cancer Control Alberta
Sponsor class: OTHER
Collaborators: name: Cross Cancer Institute
First posted: 2006-09-12
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Diagnosed with head and neck cancer including the lip, oral cavity, salivary glands, paranasal sinuses, oropharynx, nasopharynx, hypopharynx, larynx, and thyroid

Brief summary: The investigators hope to learn more about how side-effects of RT or RTchemo affect food intake and nutrition status.

Detailed description: Head and neck cancer patients often have difficulty meeting their nutritional needs while undergoing radiation therapy (RT) and/or chemotherapy (RTchemo). Tumor locations and side effects of RT or RTchemo, including dry mouth, mouth sores, difficulty chewing and swallowing, changes in taste and smell, and loss of appetite, lead to poor food intake and weight loss. The investigators hope to learn more about how side-effects of RT or RTchemo affect food intake and nutrition status.

Eligibility criteria: Inclusion Criteria:

* 18 years or older
* Diagnosed with head and neck cancer including the lip, oral cavity, salivary glands, paranasal sinuses, oropharynx, nasopharynx, hypopharynx, larynx, and thyroid
* All histological types of cancer
* All tumour stages according to American Joint Committee for Cancer (AJCC) Staging
* All forms of RT including standard or investigational and/or concurrent standard or investigational chemotherapy for head and neck cancers
* Alert and mentally competent
* English speaking

Exclusion Criteria:

* Unwilling to participate

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Edmonton
country: Canada
facility: Cross Cancer Institute
state: Alberta
Study officials:
affiliation: AHS Cancer Control Alberta
name: Vickie Baracos, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01985880: The Efficacy of Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome
Official title: Experimental Study of Biomarker in Patient With Interstitial Cystitis/Painful Bladder
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Interstitial Cystitis
Keywords: Biomarkers
Lead sponsor: Asan Medical Center
Sponsor class: OTHER
First posted: 2013-11-15
Enrollment: 67
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients \>20 years old with interstitial cystitis control

Brief summary: The purpose of this study is to evaluate efficacy of biomarker in patient with interstitial cystitis/painful bladder syndrome

Detailed description: This is a observational study

Eligibility criteria: Inclusion Criteria:

* 1) must have experienced bladder pain, urinary urgency and urinary frequency, for at least 6 months prior to entry into the study 2) Pain VAS ≥4 3) O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q) symptom and problem ≥ 12( and pain ≥2, and nocturia ≥ 2) 4) PUF score ≥ 13 5) cystoscopic record within 2 years

Exclusion Criteria:

1. Patients who are pregnancy or, childbearing age without no contraception
2. Patients with voided volume \<40 or, \> 400ml
3. Patients with microscopic hematuria, (≥1+ in dipstick), If not excluded that no evidence of neoplastic tumor examination
4. Patients with urine culture showing evidence of urinary tract infection 1month prior to the study
5. Accompanied medical problem below

   * Tuberculosis in urinary system
   * Bladder cancer, urethral cancer, prostate cancer
   * Recurrent cystitis
   * anatomical disorder
6. Patients had prior surgery (eq, bladder augmentation, cystectomy
7. Patients with neurologic disorder
8. Patients with indwelling catheter or intermittent self-catheterization
9. Patients with psychologic problem

Primary outcomes:
measure: To compare of expression of the biomarker such as APF, HB-EGF, MCP-1 among the Hunner's ulcer interstitial cystitis and non-ulcer interstitial cystitis and control groups
timeFrame: 1month
Secondary outcomes:
measure: To compare of changes voiding parameters after bladder biopsy between Hunner' ulcer group and non-ulcer group
timeFrame: 1 month
measure: TO compare of change of scores of questionnaires such as O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q), Pelvic Pain and Urgency/Frequency Patient Symptom Scale(PUF), Visual Analogue Scale (Pain) between Hunner's ulcer group and non-ulcer group
timeFrame: 1month
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Asan medical center Institutional review board
Study officials:
affiliation: Asan Medical Center
name: Myung-Soo Choo, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02082080: Prevention and Control of Obesity in Primary School Children in Tehran
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Childhood Obesity Prevention
Lead sponsor: Tehran University of Medical Sciences
Sponsor class: OTHER
First posted: 2014-03-10
Enrollment: 360
Sex: ALL
Minimum age (years): 9
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study evaluates the effect of an interventional model for preventing and controlling overweight and obesity in male and female fifth-graders. First, based on WHO (World Health Organization) references obese (BMI-Z score ≥ 2) and overweight (BMI-Z score ≥ 1) students from 12 primary schools (randomly allocated to 6 intervention and 6 comparison) will be screened. Then from the screened students 30 students with the following inclusion criteria will be recruited: not metabolically ill, not on a weight losing diet and not professionally athlete. For selected students BMI-Z score as primary outcome will be calculated. Demographic data, as well as data on waist and hip circumference, triceps skin-fold thickness, food intake for 3 days (2 ordinary week days and 1 weekend) and physical activity will be collected at the beginning and at end of the 6-month intervention. The approach of the study will be Health Promoting Schools. The intervention includes three components, i.e., nutrition education (students and parents), increased physical activity, and changing environment (food items offered in schools' canteens). Nutrition education will be imparted (a 30-minute session per week) by health instructors; physical activity will be done under the supervision of the school coaches (2 one-hour sessions per week). Parents' education (a 1.5-hour session) will be monthly. Finally the efficacy of the intervention will be determined and reported.


Eligibility criteria: Inclusion Criteria:

* BMI-Z-Score\> or =1 (WHO)
* Students in the fifth or sixth grades

Exclusion Criteria:

* Metabolic disorders (hypo or hyperthyroidism)
* Any disease which interfere with adherence to the intervention
* Intake of any appetite-reducing drug
* Doing professional sports
* Being on a weight reduction diet

Primary outcomes:
measure: Change from baseline in pain on the 11-point Short Pain Scale (SPS-11) at week 24 Change from baseline BMI (Body Mass Index) at 6 months
timeFrame: Baseline, month 6
Secondary outcomes:
Other outcomes:
Locations:
city: Tehran
country: Iran, Islamic Republic of
facility: Tehran University of Medical Sciences
Study officials:
References:
Clinical trial NCT00006162: Lifestyle Interventions to Reduce Diabetes Risk
Official title: Interventions to Reduce Diabetic Risk in Japanese Americans
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Glucose Intolerance
Diabetes Mellitus, Type 2
Keywords: low fat diet
aerobic exercise
impaired glucose tolerance
Japanese Americans
metabolic risk factors
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Sponsor class: NIH
First posted: 2000-08-09
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Primary purpose: PREVENTION

Brief summary: Type 2 diabetes is more frequent in Japanese Americans than in Japan or the U.S. non-Hispanic white population. This appears to be due to the effects of ''westernization'' to bring out metabolic changes that lead to diabetes. This study will look at whether increased physical activity and dietary changes will reduce or prevent the metabolic changes that lead to type 2 diabetes in Japanese Americans who have impaired glucose tolerance, a condition intermediate between normal glucose tolerance and diabetes.


Eligibility criteria: Inclusion Criteria:

* Japanese American
* Confirmed impaired glucose tolerance
* Able to fill out questionnaires

Exclusion Criteria:

* Significant exercise-restricting disease
* Poorly controlled hypertension
* Psychiatric disease or dementia
* Already on unusually restrictive diet
* Use of hypolipidemic drugs
* Use of tobacco
* Abnormal blood screening tests
* ECG evidence of ischemic heart disease at rest
* Abnormal maximal Bruce treadmill test

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Seattle
country: United States
facility: University of Washington
state: Washington
Study officials:
References:
Clinical trial NCT05564962: Quality and Independence of Gait Classification Scale for DMD (QIGS-DMD)
Official title: Quality and Independence of Gait Classification Scale for Duchenne Muscular Dystrophy (QIGS-DMD): The Development, Validity and Reliability
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Gait Disorders in Children
Keywords: Duchenne Muscular Dystrophy
scale development
gait
classification
reliability
validitiy
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2022-10-04
Enrollment: 69
Sex: MALE
Minimum age (years): 5
Maximum age (years): 18
Standard ages: CHILD
ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Study population consisted of patients with Duchenne Muscular Dystrophy

Brief summary: The aim of this study was to develop a reliable and valid gait classification scale for Duchenne Muscular Dystrophy (QIGS-DMD). The items of the QIGS-DMD were designed based on the literature review considering existing functional classification scales, gait scales, and the opinions of the physiotherapists who were expertized in rehabilitation of patients with DMD. Content validity was determined based on the opinions of a total of ten expert physiotherapists. Videos were recorded during gait of 69 children with DMD and inter- and intra-rater reliability were examined. Criterion validity was determined according to the relationship between QIGS-DMD and Motor Function Measure (MFM) and Vignos Lower Extremity Rating Scale (VLERS).


Eligibility criteria: Inclusion Criteria:

* being 5 years old or above, and
* having a confirmed diagnosis of Duchenne Muscular Dystrophy.

Exclusion Criteria:

* having other coexisting medical or psychiatric diseases or injury and/or surgery related to the lower extremities within the last 6 months

Primary outcomes:
measure: Quality and Independence of Gait Classification Scale for Duchenne Muscular Dystrophy (QIGS-DMD)
timeFrame: 10 minutes
Secondary outcomes:
measure: Motor Fucntion Measure (MFM)
timeFrame: 20-30 minutes
measure: Vignos Lower Extremity Rating Scale (VLERS)
timeFrame: 10 minutes
Other outcomes:
Locations:
city: Isparta
country: Turkey
facility: Güllü Aydın Yağcıoğlu
Study officials:
affiliation: Hacettepe University
name: Güllü Aydın Yağcıoğlu, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02036762: STRETCH OF RESPIRATORY MUSCLES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Official title: EFFECTS OF RESPIRATORY MUSCLE STRETCH ON THORACOABDOMINAL MECHANIC, FUNCTIONAL CAPACITY, PSYCHOLOGICAL AND SOCIAL ASPECTS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Dyspnea
Quality of Life
Respiratory Symptoms
Keywords: Chronic Obstructive Pulmonary Disease
Thoracoabdominal Mechanics
Functional capacity
Quality of life
Lead sponsor: University of Sao Paulo
Sponsor class: OTHER
First posted: 2014-01-15
Enrollment: 24
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: THE AIM OF THIS STUDY IS TO TEST IF THE STRETCHING OF THE RESPIRATORY ACCESSORY MUSCLE PROVIDE SOME BENEFIT ON THORACOABDOMINAL MECHANICS, FUNCTIONAL CAPACITY, PSYCHOLOGICAL AND SOCIAL ASPECTS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Detailed description: PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE WILL BE SUBMITTED TO PASSIVE STRETCHING OF RESPIRATORY MUSCLES AND EXERCISE IN TREADMILL DURING 12 WEEKS, TWICE A WEEK. ONE WEEK AFTER THE TRAINING PERIOD, THE FUNCTIONAL CAPACITY, THE THORACOABDOMINAL MECHANICS AND LEVELS OF ANXIETY AND DEPRESSION WILL BE ASSESSED.

Eligibility criteria: Inclusion Criteria:

* Chronic Obstructive Pulmonary Disease Diagnosis
* Clinical stability
* Absence of previous thoracic surgery
* Absence of other limitations

Exclusion Criteria:

* Copd exacerbation
* Absence greater than three days

Primary outcomes:
measure: Functional Capacity
timeFrame: One week after the end of training
Secondary outcomes:
measure: Thoracoabdominal mechanics
timeFrame: One week after the end of training
Other outcomes:
measure: Anxiety and depression
timeFrame: One week after the end of training
Locations:
city: Sao Paulo
country: Brazil
facility: FOFITO
city: Sao Paulo
country: Brazil
facility: Hospital das Clinicas
city: São Paulo
country: Brazil
facility: Physiotherapy Departament of University of São Paulo
Study officials:
affiliation: Physiotherapy Departament of University of São Paulo
name: Celso Carvalho, Dr.
role: STUDY_DIRECTOR
References:
Clinical trial NCT06654362: The Effect of Multimodal Nutrition Intervention on Glucose and Lipid Parameters of Arfa Iron and Steel Company Workers
Official title: The Effect of Multimodal Nutrition Intervention on Glucose and Lipid Parameters of Arfa Iron and Steel Company Workers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Blood Sugar
Lipid Profile
Weight Change
Keywords: public health
workers
nutrition
Lead sponsor: Shahid Sadoughi University of Medical Sciences and Health Services
Sponsor class: OTHER
First posted: 2024-10-23
Enrollment: 1097
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The goal of this clinical trial is to investigate the impact of nutritional interventions on glycemic and lipid profile factors among workers.

The main questions it aims to answer are:

Does nutritional interventions (include: nutritional education and Change in the Factory Restaurant's Menu improve glycemic and lipid profile factors among workers? Researchers will compare glycemic and lipid profile factors among workers before and after nutritional intervention .


Eligibility criteria: Inclusion Criteria:

* be Arfa's company worker

Exclusion Criteria:

* individuals who were diagnosed with any type of cancer

Primary outcomes:
measure: Total Cholesterol, mg/dL
timeFrame: From enrollment to the end of intervention at 6 months
measure: Total triglycerides, mg/dL
timeFrame: From enrollment to the end of intervention at 6 months
measure: Low-density lipoprotein, mg/dL
timeFrame: From enrollment to the end of intervention at 6 months
measure: High-density lipoprotein, mg/dl
timeFrame: From enrollment to the end of intervention at 6 months
measure: Fast blood sugar, mg/dL
timeFrame: From enrollment to the end of intervention at 6 months
measure: serum glutamic oxaloacetic transaminase, IU/L
timeFrame: From enrollment to the end of intervention at 6 months
measure: serum glutamic pyruvic transaminase, IU/L
timeFrame: From enrollment to the end of intervention at 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Yazd
country: Iran, Islamic Republic of
facility: Shahid Sadoughi University of Medical Sciences
Study officials:
References:
Clinical trial NCT03041662: Surveillance Study for Early Detection of Cholangiocarcinoma (CCA) in Primary Sclerosing Cholangitis (PSC)
Official title: Surveillance Study for Early Detection of Cholangiocarcinoma (CCA) in Primary Sclerosing Cholangitis (PSC)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Primary Sclerosing Cholangitis
Cholangiocarcinoma
Lead sponsor: Karolinska University Hospital
Sponsor class: OTHER
First posted: 2017-02-03
Enrollment: 620
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: National Swedish cohort of PSC patients followed at 14 hospitals

Brief summary: This observational study of a national cohort of 600 Swedish PSC patients include yearly MR/MRCP, biobanking of serum, plasma and blood, followup clinical data (interventions, symptoms, labs, colonoscopy). The aim is to collect a well characterized cohort of PSC patients and provide future possibilities to evaluate biomarkers for prognosis and early cancer detection.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of PSC by MR/MRCP
* Life expectancy \>1 year
* Informed consent

Exclusion Criteria:

* Liver transplantation or on the waiting list
* Secondry SC
* Diagnosis of CCA

Primary outcomes:
measure: cholangiocarcinoma
timeFrame: 10 yrs f-up
measure: liver transplatation
timeFrame: 10 yrs f-up
measure: death
timeFrame: 10 yrs f-up
Secondary outcomes:
measure: biliary dysplasia
timeFrame: 10 yrs f-up
Other outcomes:
Locations:
city: Stockholm
country: Sweden
facility: Karolinska University Hospital, Huddinge
Study officials:
References:
Clinical trial NCT06645262: First-degree Ankle Sprains
Official title: First-degree Ankle Sprains
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Ankle Sprain 1St Degree
Keywords: ankle sprain
Bowen technique
Lead sponsor: Rehabilitation Centre Zivot
Sponsor class: OTHER
First posted: 2024-10-16
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The sample is a convenience sample and will include individuals diagnosed with Grade I acute ankle sprain who present for examination at the specified institutions. After a proper diagnosis, confirmation of inclusion in the study, and signed ethical consent for participation in the research, randomization of participants will be conducted using an electronic number generator on the website www.randomizer.org/form:htm.

Brief summary: Grade I ankle sprains are common, especially among athletes, women, teenagers, and physically active individuals. While over a million cases are reported annually, this represents only half of the total occurrences. These injuries can lead to complications like chronic ankle instability or osteoarthritis. Treatment often involves conservative methods, including the PRICEMMS protocol (protection, rest, ice, compression, elevation, modalities, medication, and support), while surgery is reserved for severe cases. Therapeutic exercises and rehabilitation play a key role in recovery. The Bowen technique, effective for other musculoskeletal issues, has not yet been extensively studied for Grade I ankle sprains.


Eligibility criteria: Inclusion Criteria:

* Individuals diagnosed with Grade I acute ankle sprain confirmed by a specialist physician in radiology,
* Age of participants ≥ 18 years,
* Individuals of both sexes

Exclusion Criteria:

* Recurrent ankle injury,
* Acute ankle sprains of Grade II and III,
* Presence of other physical and/or mental health issues.

Primary outcomes:
measure: Subjective assessment of pain intensity
timeFrame: 3 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Mostar
country: Bosnia and Herzegovina
facility: Rehabilitation Centre Život
Study officials:
References: