Clinical trial NCT06430801: A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
Official title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Program to Evaluate the Efficacy and Safety of Tulisokibart in Participants With Moderately to Severely Active Crohn's Disease
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Crohn's Disease
Lead sponsor: Merck Sharp & Dohme LLC
Sponsor class: INDUSTRY
First posted: 2024-05-28
Enrollment: 1200
Sex: ALL
Minimum age (years): 16
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this protocol is to evaluate the efficacy and safety of tulisokibart in participants with moderately to severely active Crohn's disease. Study 1's primary hypotheses are that at least 1 tulisokibart dose level is superior to placebo in the proportion of participants achieving clinical remission per Crohn's Disease Activity Index score (\<150, US/FDA) or per stool frequency and abdominal pain score (EU/EMA) and in the proportion of participants achieving endoscopic response at Week 52 (US/FDA and EU/EMA), and that at least 1 tulisokibart dose level is superior to placebo in the proportion of participants achieving clinical remission per Crohn's Disease Activity Index score (\<150, US/FDA) or per stool frequency and abdominal pain score (EU/EMA) and in the proportion of participants achieving endoscopic response at Week 12 (US/FDA and EU/EMA). Study 2's primary hypothesis is that at least 1 tulisokibart dose level is superior to placebo in the proportion of participants achieving clinical remission per Crohn's Disease Activity Index score (\<150, US/FDA) or stool frequency and abdominal pain score (EU/EMA) and in the proportion of participants achieving endoscopic response at Week 12 (US/FDA and EU/EMA).

Detailed description: The protocol consists of 2 studies. Study 1 includes induction and maintenance treatment, and Study 2 includes only induction treatment. Each study has its own hypotheses and outcome measures that will be assessed independently.

Eligibility criteria: The main inclusion and exclusion criteria include but are not limited to the following:

Inclusion Criteria:

* Has had a diagnosis of CD at least 3 months before study.
* Has moderately to severely active CD.
* Demonstrated inadequate response, loss of response, or intolerance to one or more of the following categories of drugs: oral locally acting steroids, systemic steroids, immunomodulators, biologic and/or small molecule advanced therapies.
* Adolescent participants ≥16 and \<18 years of age can participate if approved by the country or regulatory/health authority.

Exclusion Criteria:

* Has diagnosis of ulcerative colitis (UC) or indeterminate colitis.
* Has CD isolated to the stomach, duodenum, jejunum, or perianal region, without colonic and/or ileal involvement.
* Currently has any of the following complications of CD: suspected or diagnosed with intra-abdominal or perianal abscess, known symptomatic stricture or colonic stenosis not passable in endoscopy, fulminant colitis, toxic megacolon, or any other manifestation that might require surgery while enrolled in the study.
* Has current stoma or need for colostomy or ileostomy.
* Is missing \>2 segments of the following 5 segments: terminal ileum, right colon, transverse colon, sigmoid and left colon, and rectum.
* Has been diagnosed with short gut or short bowel syndrome, or any other uncontrolled chronic diarrhea besides Crohn's disease.
* Has surgical bowel resection within 3 months of study.
* Has prior or current gastrointestinal dysplasia.
* Has chronic infection requiring ongoing antimicrobial treatment.
* Has a history of cancer (except fully treated non-melanoma skin cell cancers or cervical carcinoma in situ after complete surgical removal) and is disease free for \<5 years.
* Is infected with Hepatitis B virus (HBV), Hepatitis C virus (HCV), or human immunodeficiency virus (HIV).
* Has active tuberculosis.
* Has confirmed or suspected coronavirus disease of 2019 (COVID-19) infection.
* Prior exposure to tulisokibart (MK-7240, PRA023) or another anti-TL1A antibody.

Primary outcomes:
measure: Study 1 [US/FDA Only]: Percentage of Participants Achieving Clinical Remission per Crohn's Disease Activity Index (CDAI) Score at Week 52
timeFrame: Week 52
measure: Study 1 [EU/EMA Only]: Percentage of Participants Achieving Clinical Remission per Stool Frequency and Abdominal Pain Score at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants Achieving Endoscopic Response at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants Achieving Clinical Remission per CDAI Score at Week 12
timeFrame: Week 12
measure: Study 1: Percentage of Participants Achieving Clinical Remission per Stool Frequency and Abdominal Pain Score at Week 12
timeFrame: Week 12
measure: Study 1: Percentage of Participants Achieving Endoscopic Response at Week 12
timeFrame: Week 12
measure: Study 2 [US/FDA Only]: Percentage of Participants Achieving Clinical Remission per CDAI Score at Week 12
timeFrame: Week 12
measure: Study 2 [EU/EMA Only]: Percentage of Participants Achieving Clinical Remission per Stool Frequency and Abdominal Pain Score at Week 12
timeFrame: Week 12
measure: Study 2: Percentage of Participants Achieving Endoscopic Response at Week 12
timeFrame: Week 12
Secondary outcomes:
measure: Study 1: Percentage of Participants Who Experienced an Adverse Event (AE)
timeFrame: Up to approximately 52 weeks
measure: Study 1: Percentage of Participants who Discontinue Study Intervention due to an AE
timeFrame: Up to approximately 52 weeks
measure: Study 1 [US/FDA Only]: Percentage of Participants Achieving Clinical Remission per Stool Frequency and Abdominal Pain Score at Week 12
timeFrame: Week 12
measure: Study 1 [EU/EMA Only]: Percentage of Participants Achieving Clinical Remission per CDAI Score at Week 12
timeFrame: Week 12
measure: Study 1: Percentage of Participants with Decrease of ≥100 Points in CDAI Score from Baseline to Week 12
timeFrame: Week 12
measure: Study 1: Mean Change from Baseline in Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-Fatigue) Score at Week 12
timeFrame: Baseline and Week 12
measure: Study 1: Percentage of Participants Achieving Endoscopic Remission at Week 12
timeFrame: Week 12
measure: Study 1 and 2: Percentage of Participants in Diagnostic Assay Positive (Dx+) Subpopulation Achieving Clinical Remission per CDAI at Week 12
timeFrame: Week 12
measure: Study 1 and 2: Percentage of Participants in Diagnostic Assay Positive (Dx+) Subpopulation Achieving Endoscopic Response at Week 12
timeFrame: Week 12
measure: Study 1 [US/FDA Only]: Percentage of Participants Achieving Clinical Remission per Stool Frequency and Abdominal Pain Score at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants Achieving Clinical Remission per CDAI Score at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants with Decrease of ≥100 Points in CDAI Score from Baseline to Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants Achieving Endoscopic Remission at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants Achieving Sustained Clinical Remission per CDAI at Both Week 12 and Week 52
timeFrame: Week 12 and Week 52
measure: Study 1: Percentage of Participants Achieving Corticosteroid-Free Clinical Remission per CDAI Score at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants Achieving Corticosteroid-Free Clinical Remission per Stool Frequency and Abdominal Pain Score at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants Achieving Clinical Remission per Stool Frequency, Abdominal Pain Score, and Endoscopic Remission at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants Achieving Clinical Remission per CDAI and Endoscopic Remission at Week 52
timeFrame: Week 52
measure: Study 1: Mean Change from Baseline in FACIT-Fatigue Score at Week 52
timeFrame: Baseline and Week 52
measure: Study 1: Mean Change from Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Score at Week 52
timeFrame: Baseline and Week 52
measure: Study 1: Percentage of Participants with Ulcer-Free Endoscopy at Week 52
timeFrame: Week 52
measure: Study 2: Percentage of Participants Who Experienced an AE
timeFrame: Up to approximately 12 weeks
measure: Study 2: Percentage of Participants who Discontinue Study Intervention due to an AE
timeFrame: Up to approximately 12 weeks
measure: Study 2 [US/FDA Only]: Percentage of Participants Achieving Clinical Remission per Stool Frequency and Abdominal Pain Score at Week 12
timeFrame: Week 12
measure: Study 2 [EU/EMA Only]: Percentage of Participants Achieving Clinical Remission per CDAI Score at Week 12
timeFrame: Week 12
measure: Study 2: Percentage of Participants with Decrease of ≥100 Points in CDAI Score from Baseline to Week 12
timeFrame: Week 12
measure: Study 2: Mean Change from Baseline in FACIT-Fatigue Score at Week 12
timeFrame: Baseline and Week 12
measure: Study 2: Percentage of Participants Achieving Endoscopic Remission at Week 12
timeFrame: Week 12
measure: Study 2: Mean Change from Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Score at Week 12
timeFrame: Baseline and Week 12
measure: Study 2: Percentage of Participants with Decrease of ≥100 Points in CDAI Score from Baseline to Week 6
timeFrame: Week 6
measure: Study 2: The percentage of Participants with Ulcer-Free Endoscopy at Week 12
timeFrame: Week 12
Other outcomes:
Locations:
city: Dothan
country: United States
facility: Digestive Health Specialists ( Site 5064)
state: Alabama
city: Sun City
country: United States
facility: GI Alliance - Sun City ( Site 5118)
state: Arizona
city: Tucson
country: United States
facility: University of Arizona Clinical and Translational Sciences Research Center ( Site 5111)
state: Arizona
city: Anaheim
country: United States
facility: Clinnova Research ( Site 5110)
state: California
city: Camarillo
country: United States
facility: Om Research LLC ( Site 5045)
state: California
city: Coronado
country: United States
facility: Southern California Research Center ( Site 5044)
state: California
city: Lancaster
country: United States
facility: Om Research LLC ( Site 5038)
state: California
city: Valencia
country: United States
facility: Amicis Research Center - Valencia ( Site 5055)
state: California
city: Aurora
country: United States
facility: University of Colorado Anschutz Medical Campus-Division of Gastroenterology and Hepatology ( Site 5026)
state: Colorado
city: Colorado Springs
country: United States
facility: Peak Gastroenterology Associates ( Site 5023)
state: Colorado
city: Hamden
country: United States
facility: Medical Research Center of Connecticut ( Site 5005)
state: Connecticut
city: Washington
country: United States
facility: Emerson Clinical Research Institute ( Site 5051)
state: District of Columbia
city: Clearwater
country: United States
facility: Gastroenterology Consultants of Clearwater ( Site 5052)
state: Florida
city: Inverness
country: United States
facility: Nature Coast Clinical Research - Inverness ( Site 5042)
state: Florida
city: Margate
country: United States
facility: Atlantic Medical Research ( Site 5073)
state: Florida
city: Orlando
country: United States
facility: Endoscopic Research Inc ( Site 5061)
state: Florida
city: Orlando
country: United States
facility: Orlando Health-Digestive Health Institute ( Site 5010)
state: Florida
city: Tampa
country: United States
facility: USF Health Carol and Frank Morsani Center for Advanced Healthcare ( Site 5039)
state: Florida
city: Decatur
country: United States
facility: Atlanta Center for Gastroenterology ( Site 5035)
state: Georgia
city: Macon
country: United States
facility: Gastroenterology Associates of Central Georgia ( Site 5048)
state: Georgia
city: Chicago
country: United States
facility: Eagle Clinical Research ( Site 5089)
state: Illinois
city: Chicago
country: United States
facility: University of Chicago Medical Center ( Site 5066)
state: Illinois
city: Evanston
country: United States
facility: Endeavor Health ( Site 5018)
state: Illinois
city: Gurnee
country: United States
facility: GI ALLIANCE - GURNEE ( Site 5003)
state: Illinois
city: Indianapolis
country: United States
facility: Indiana University Health University Hospital ( Site 5022)
state: Indiana
city: Clive
country: United States
facility: Iowa Digestive Disease Center ( Site 5007)
state: Iowa
city: Topeka
country: United States
facility: Cotton O'Neil Digestive Health Center ( Site 5033)
state: Kansas
city: Zachary
country: United States
facility: Southern Clinical Research ( Site 5095)
state: Louisiana
city: Ann Arbor
country: United States
facility: University of Michigan ( Site 5060)
state: Michigan
city: Clinton Township
country: United States
facility: Clinical Research Institute of Michigan, LLC ( Site 5002)
state: Michigan
city: Liberty
country: United States
facility: BVL Research - Kansas ( Site 5099)
state: Missouri
city: Saint Louis
country: United States
facility: Washington University School of Medicine ( Site 5058)
state: Missouri
city: Hackensack
country: United States
facility: HMHN Justice Marie Garibaldi Medical Plaza ( Site 5072)
state: New Jersey
city: Great Neck
country: United States
facility: Northwell Health Division of Gastroenterology at Great Neck ( Site 5017)
state: New York
city: Middletown
country: United States
facility: Circuit Clinical /Crystal Run Healthcare LLP ( Site 5050)
state: New York
city: New York
country: United States
facility: NYU Langone Health - Inflammatory Bowel Disease Center (IBD) ( Site 5078)
state: New York
city: New York
country: United States
facility: Weill Cornell Medical College, New-York Presbyterian Hospital ( Site 5079)
state: New York
city: New York
country: United States
facility: New York Gastroenterology Associates ( Site 5013)
state: New York
city: Chapel Hill
country: United States
facility: University of North Carolina Medical Center ( Site 5034)
state: North Carolina
city: Charlotte
country: United States
facility: Atrium Health Gastroenterology MMP ( Site 5105)
state: North Carolina
city: Charlotte
country: United States
facility: Javara - Tryon Medical Partners ( Site 5046)
state: North Carolina
city: Mentor
country: United States
facility: Great Lakes Gastroenterology Research, LLC ( Site 5016)
state: Ohio
city: Oklahoma City
country: United States
facility: Digestive Disease Specialists Inc. ( Site 5117)
state: Oklahoma
city: Uniontown
country: United States
facility: Frontier Clinical Research, LLC ( Site 5098)
state: Pennsylvania
city: Providence
country: United States
facility: University Gastroenterology - Providence - West River Street ( Site 5057)
state: Rhode Island
city: Nashville
country: United States
facility: Vanderbilt Inflammatory Bowel Disease Clinic ( Site 5049)
state: Tennessee
city: Nashville
country: United States
facility: Quality Medical Research ( Site 5114)
state: Tennessee
city: Dallas
country: United States
facility: Baylor University Medical Center ( Site 5031)
state: Texas
city: Dallas
country: United States
facility: GI Alliance - Dallas - Gaston Avenue ( Site 5054)
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine Medical Center ( Site 5020)
state: Texas
city: Lubbock
country: United States
facility: GI Alliance - Lubbock ( Site 5012)
state: Texas
city: Lubbock
country: United States
facility: Caprock Gastro Research ( Site 5077)
state: Texas
city: Mansfield
country: United States
facility: GI Alliance: Mansfield ( Site 5015)
state: Texas
city: San Antonio
country: United States
facility: Southern Star Research Institute ( Site 5000)
state: Texas
city: Southlake
country: United States
facility: GI Alliance - Southlake ( Site 5109)
state: Texas
city: Tyler
country: United States
facility: Tyler Research Institute ( Site 5001)
state: Texas
city: Richmond
country: United States
facility: Richmond VA Medical Center ( Site 5021)
state: Virginia
city: Bellevue
country: United States
facility: Washington Gastroenterology - Bellevue ( Site 5040)
state: Washington
city: Seattle
country: United States
facility: Swedish Medical Center ( Site 5112)
state: Washington
city: Tacoma
country: United States
facility: Washington Gastroenterology - Tacoma ( Site 5004)
state: Washington
city: Concord
country: Australia
facility: Concord Repatriation General Hospital-Gastroenterology and Liver Services ( Site 3202)
state: New South Wales
city: Brisbane
country: Australia
facility: Royal Brisbane and Women's Hospital ( Site 3200)
state: Queensland
city: Adelaide
country: Australia
facility: Royal Adelaide Hosp - GI Clinical Trials ( Site 3203)
state: South Australia
city: Clayton
country: Australia
facility: Monash Health-Gastroenterology ( Site 3206)
state: Victoria
city: Melbourne
country: Australia
facility: The Alfred Hospital-Gastroenterology ( Site 3201)
state: Victoria
city: Innsbruck
country: Austria
facility: Medizinische Universitaet Innsbruck-Innere Medizin 1 ( Site 0200)
state: Tirol
city: Vienna
country: Austria
facility: Medizinische Universität Wien-Klinik für Innere Medizin III - Abteilung für Gastroenterologie und H ( Site 0202)
state: Wien
city: Salzburg
country: Austria
facility: Uniklinikum Salzburg-Innere Medizin I ( Site 0201)
city: Gent
country: Belgium
facility: UZ Gent ( Site 0300)
state: Oost-Vlaanderen
city: Leuven
country: Belgium
facility: UZ Leuven-Gastroenterology - Inflammatory Bowel Disease ( Site 0301)
state: Vlaams-Brabant
city: Roeselare
country: Belgium
facility: AZ Delta vzw-Gastroenterology ( Site 0304)
state: West-Vlaanderen
city: Calgary
country: Canada
facility: Heritage Medical Research Clinic ( Site 0004)
state: Alberta
city: Lethbridge
country: Canada
facility: SIX08 Gastroenterology ( Site 0015)
state: Alberta
city: New Westminster
country: Canada
facility: Fraser Clinical Trials Inc ( Site 0001)
state: British Columbia
city: Vancouver
country: Canada
facility: G.I.R.I. GI Research Institute Foundation ( Site 0018)
state: British Columbia
city: Barrie
country: Canada
facility: Barrie GI Associates ( Site 0016)
state: Ontario
city: London
country: Canada
facility: Victoria Hospital & Children's Hospital - London Health Sciences Centre ( Site 0007)
state: Ontario
city: Mississauga
country: Canada
facility: West GTA Research Inc. ( Site 0020)
state: Ontario
city: Oakville
country: Canada
facility: ABP Research Services Corp. ( Site 0019)
state: Ontario
city: Toronto
country: Canada
facility: Toronto Immune & Digestive Health Institute ( Site 0005)
state: Ontario
city: Vaughan
country: Canada
facility: Toronto Digestive Disease Associates ( Site 0006)
state: Ontario
city: Montreal
country: Canada
facility: Montreal General Hospital ( Site 0003)
state: Quebec
city: Quebec
country: Canada
facility: Diex Recherche Quebec ( Site 0008)
city: Temuco
country: Chile
facility: Hospital hernan henriquez aravena de temuco ( Site 2607)
state: Araucania
city: Concepción
country: Chile
facility: Hospital Clínico Regional Dr. Guillermo Grant Benavente ( Site 2604)
state: Biobio
city: Santiago
country: Chile
facility: FALP-UIDO ( Site 2600)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Clínica Alemana de Santiago-Unidad de Investigaciones ( Site 2602)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Espacio Eme ( Site 2608)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: CECIM ( Site 2603)
state: Region M. De Santiago
city: Vina del Mar
country: Chile
facility: Centro de Investigaciones Clinicas Vina del Mar ( Site 2606)
state: Valparaiso
city: Hefei
country: China
facility: Anhui Provincial Hospital ( Site 3922)
state: Anhui
city: Beijing
country: China
facility: Peking University Third Hospital ( Site 3910)
state: Beijing
city: Chongqing
country: China
facility: Chongqing General Hospital ( Site 3940)
state: Chongqing
city: Fuzhou
country: China
facility: The First Affiliated Hospital Of Fujian Medical University ( Site 3916)
state: Fujian
city: XiaMen
country: China
facility: The First Affiliated hospital of Xiamen University ( Site 3924)
state: Fujian
city: Xiamen
country: China
facility: Zhongshan Hospital Affiliated to Xiamen University ( Site 3923)
state: Fujian
city: Dongguan
country: China
facility: Dongguan People's Hospital ( Site 3933)
state: Guangdong
city: Guangzhou
country: China
facility: The First Affiliated Hospital, Sun Yat-sen University ( Site 3901)
state: Guangdong
city: Guangzhou
country: China
facility: The Sixth Affiliated Hospital of Sun Yat-sen University ( Site 3907)
state: Guangdong
city: Huizhou
country: China
facility: Huizhou Municipal Central Hospital ( Site 3915)
state: Guangdong
city: Shenzhen
country: China
facility: The University of Hong Kong-Shenzhen Hospital ( Site 3930)
state: Guangdong
city: Shenzhen
country: China
facility: Shenzhen Hospital of Southern Medical University ( Site 3932)
state: Guangdong
city: Shijiazhuang
country: China
facility: The Second Afilliated Hospital of Hebei Medical University ( Site 3913)
state: Hebei
city: Zhengzhou
country: China
facility: The Second Affiliated Hospital of Zhengzhou University ( Site 3909)
state: Henan
city: Shiyan
country: China
facility: Taihe Hospital ( Site 3944)
state: Hubei
city: Wuhan
country: China
facility: Renmin Hospital of Wuhan University ( Site 3921)
state: Hubei
city: Changsha
country: China
facility: The Second Xiangya Hospital of Central South University-gastroenterology department ( Site 3905)
state: Hunan
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School ( Site 3937)
state: Jiangsu
city: Nanjing
country: China
facility: Zhongda Hospital Southeast University-Gastroenterology ( Site 3911)
state: Jiangsu
city: Wuxi
country: China
facility: Wuxi People's Hospital ( Site 3925)
state: Jiangsu
city: Zhenjiang
country: China
facility: Affiliated Hospital of Jiangsu University ( Site 3919)
state: Jiangsu
city: Zhenjiang
country: China
facility: Changzhou No.2 People's Hospital ( Site 3904)
state: Jiangsu
city: Xian
country: China
facility: Tangdu Hospital of Fourth Military Medical University of Chinese People's Liberation Army ( Site 3918)
state: Shaanxi
city: Shanghai
country: China
facility: Ruijin Hospital Shanghai Jiaotong University School of Medicine ( Site 3931)
state: Shanghai
city: Shanghai
country: China
facility: Huashan Hospital of Fudan University ( Site 3946)
state: Shanghai
city: Shanghai
country: China
facility: Shanghai East Hospital ( Site 3914)
state: Shanghai
city: Cheng Du
country: China
facility: West China Hospital, Sichuan University ( Site 3929)
state: Sichuan
city: SuiNing
country: China
facility: Suining Central Hospital ( Site 3927)
state: Sichuan
city: Kunming
country: China
facility: First Affiliated Hospital of Kunming Medical University ( Site 3928)
state: Yunnan
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital of Zhejiang University School of Medicine-GI Medicine ( Site 3902)
state: Zhejiang
city: Taizhou
country: China
facility: Taizhou Hospital of Zhejiang Province ( Site 3936)
state: Zhejiang
city: Medellín
country: Colombia
facility: Clinica Medellin S.A ( Site 2705)
state: Antioquia
city: Monteria
country: Colombia
facility: IMAT S.A.S ( Site 2700)
state: Cordoba
city: Pereira.
country: Colombia
facility: Oncologos del Occidente ( Site 2702)
state: Risaralda
city: Cali.
country: Colombia
facility: Fundación Valle del Lili ( Site 2704)
state: Valle Del Cauca
city: Zagreb
country: Croatia
facility: Poliklinika Bates ( Site 0504)
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Poliklinika Solmed ( Site 0502)
state: Grad Zagreb
city: Osijek
country: Croatia
facility: Poliklinika Borzan ( Site 0500)
state: Osjecko-baranjska Zupanija
city: Hradec Kralove
country: Czechia
facility: Hepato-Gastroenterologie HK ( Site 0652)
city: Copenhagen
country: Denmark
facility: Herlev and Gentofte Hospital ( Site 5300)
state: Hovedstaden
city: Odense C
country: Denmark
facility: Odense Universitetshospital ( Site 5301)
state: Syddanmark
city: Tampere
country: Finland
facility: Tampereen yliopistollinen sairaala ( Site 5401)
state: Pirkanmaa
city: Turku
country: Finland
facility: Turku University Hospital ( Site 5402)
state: Varsinais-Suomi
city: Nice
country: France
facility: Centre Hospitalier Universitaire de Nice - Hôpital l'Archet ( Site 0711)
state: Alpes-Maritimes
city: Pessac
country: France
facility: CHU Bordeaux Haut-Leveque ( Site 0713)
state: Aquitaine
city: Marseille
country: France
facility: Assistance Publique Hôpitaux de Marseille - Hôpital Nord ( Site 0722)
state: Bouches-du-Rhone
city: Dijon
country: France
facility: Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand ( Site 0708)
state: Bourgogne
city: Reims cedex
country: France
facility: Centre Hospitalier Universitaire de Reims - Hôpital Robert Debré ( Site 0707)
state: Champagne-Ardenne
city: Besançon
country: France
facility: CHU Besançon ( Site 0724)
state: Doubs
city: Valence
country: France
facility: Centre Hospitalier de Valence ( Site 0725)
state: Drome
city: Nimes
country: France
facility: C.H.U. de Nimes. Hopital Caremeau ( Site 0731)
state: Gard
city: Toulouse
country: France
facility: CHU Rangueil ( Site 0710)
state: Haute-Garonne
city: Clichy
country: France
facility: Hopital Beaujon ( Site 0729)
state: Hauts-de-Seine
city: Neuilly-sur-Seine
country: France
facility: CMC Ambroise Paré Hartmann - Institut des MICI ( Site 0723)
state: Hauts-de-Seine
city: Kremlin Bicetre
country: France
facility: Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 0702)
state: Ile-de-France
city: Montpellier
country: France
facility: CHU SAINT ELOI ( Site 0701)
state: Languedoc-Roussillon
city: Nantes
country: France
facility: Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu ( Site 0705)
state: Loire-Atlantique
city: Vandoeuvre-les-Nancy
country: France
facility: Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois ( Site 0717)
state: Meurthe-et-Moselle
city: Lille
country: France
facility: Hopital Claude Huriez - CHU de Lille ( Site 0715)
state: Nord
city: Pierre-Bénite
country: France
facility: centre hospitalier lyon sud ( Site 0716)
state: Rhone
city: Amiens
country: France
facility: CHU d'Amiens-Picardie - Hôpital Sud ( Site 0709)
state: Somme
city: Creteil
country: France
facility: Hopital Henri Mondor ( Site 0730)
state: Val-de-Marne
city: Paris
country: France
facility: Hôpital Saint Antoine ( Site 0721)
city: Batumi
country: Georgia
facility: LTD High Technology Hospital Medcenter ( Site 0802)
state: Ajaria
city: Tbilisi
country: Georgia
facility: New Hospitals ( Site 0800)
city: Tbilisi
country: Georgia
facility: Caraps Medline ( Site 0803)
city: Tbilisi
country: Georgia
facility: Caucasus Medical Centre ( Site 0801)
city: Pforzheim
country: Germany
facility: Siloah St. Trudpert Klinikum-Zentrum für Innere Medizin ( Site 0992)
state: Baden-Wurttemberg
city: München
country: Germany
facility: Klinikum der Universität München Großhadern ( Site 0990)
state: Bayern
city: München
country: Germany
facility: klinikum rechts der isar der technischen universität münchen ( Site 0989)
state: Bayern
city: Ulm
country: Germany
facility: Universitaetsklinikum Ulm. ( Site 0994)
state: Bayern
city: Rostock
country: Germany
facility: Universitätsmedizin Rostock ( Site 0993)
state: Mecklenburg-Vorpommern
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover ( Site 0999)
state: Niedersachsen
city: Lüneburg
country: Germany
facility: Klinikum Lüneburg ( Site 0991)
state: Niedersachsen
city: Duisburg
country: Germany
facility: Stadtische Kliniken Duisburg, Abtlg. Innere Medizin ( Site 0985)
state: Nordrhein-Westfalen
city: Koln
country: Germany
facility: Evangelisches Krankenhaus Kalk gGmbH ( Site 0986)
state: Nordrhein-Westfalen
city: Minden
country: Germany
facility: Gastroenterologische Gemeinschaftspraxis Minden ( Site 0998)
state: Nordrhein-Westfalen
city: Münster
country: Germany
facility: Medizinisches Versorgungszentrum Portal 10 ( Site 0988)
state: Nordrhein-Westfalen
city: Ludwighafen Am Rhein
country: Germany
facility: St. Marien und St. Annastift Krankenhaus ( Site 0987)
state: Rheinland-Pfalz
city: Leipzig
country: Germany
facility: Universitätsklinikum Leipzig ( Site 0997)
state: Sachsen
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel ( Site 0995)
state: Schleswig-Holstein
city: Berlin
country: Germany
facility: Charité Campus Virchow-Klinikum ( Site 0996)
city: Brandenburg
country: Germany
facility: Städtisches Klinikum Brandenburg ( Site 0903)
city: Athens
country: Greece
facility: Evangelismos General Hospital of Athens ( Site 1002)
state: Attiki
city: Athens
country: Greece
facility: THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 1004)
state: Attiki
city: Nikaia Piraeus
country: Greece
facility: General Hospital of Nikaia-Piraeus "Agios Panteleimon" ( Site 1003)
state: Attiki
city: Thessaloniki
country: Greece
facility: Ippokrateio General Hospital of Thessaloniki ( Site 1001)
state: Kentriki Makedonia
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion-GASTROENTEROLOGY & HEPATOLOGY ( Site 1000)
state: Kriti
city: Hksar
country: Hong Kong
facility: Queen Mary Hospital ( Site 3300)
city: Békéscsaba
country: Hungary
facility: Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház-4. Belgyogyaszat Gasztroenterologia ( Site 1105)
state: Bekescsaba
city: Eger
country: Hungary
facility: Heves Vármegyei Markhot Ferenc Oktatókórház és Rendelőintézet ( Site 1117)
state: Heves
city: Gyongyos
country: Hungary
facility: Gyöngyösi Bugát Pál Kórház ( Site 1111)
state: Heves
city: Tatabánya
country: Hungary
facility: Komarom-Esztergom Varmegyei Szent Borbala Korhaz ( Site 1115)
state: Komarom-Esztergom
city: Veszprém
country: Hungary
facility: VeszLife Magánklinika ( Site 1102)
state: Veszprem
city: Budapest
country: Hungary
facility: Clinexpert Kft.-Clinexpert Budapest ( Site 1108)
city: Budapest
country: Hungary
facility: Synexus Magyarorszag Kft. (Budapest DRS) ( Site 1107)
city: Budapest
country: Hungary
facility: Pannónia Magánorvosi Centrum ( Site 1103)
city: Afula
country: Israel
facility: Emek Medical Center ( Site 1206)
city: Ashkelon
country: Israel
facility: Barzilai Medical Center ( Site 1209)
city: Haifa
country: Israel
facility: Rambam Health Care Campus ( Site 1201)
city: Haifa
country: Israel
facility: Bnai Zion Medical Center ( Site 1203)
city: Holon
country: Israel
facility: Edith Wolfson Medical Center ( Site 1204)
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center ( Site 1208)
city: Kfar Saba
country: Israel
facility: Meir Medical Center. ( Site 1202)
city: Petah Tikva
country: Israel
facility: Rabin Medical Center ( Site 1207)
city: Ramat Gan
country: Israel
facility: Sheba Medical Center ( Site 1200)
city: Monserrato
country: Italy
facility: Policlinico Universitario Monserrato-SC Gastroenterologia ( Site 1313)
state: Cagliari
city: Rome
country: Italy
facility: Fondazione Policlinico Tor Vergata ( Site 1307)
state: Lazio
city: Milano
country: Italy
facility: Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-Gastroenterology and Endoscopy Unit ( Site 1304)
state: Lombardia
city: Rozzano
country: Italy
facility: Istituto Clinico Humanitas-IBD center ( Site 1309)
state: Lombardia
city: Napoles
country: Italy
facility: A.O.R.N. Ospedale dei Colli - Monaldi V. ( Site 1310)
state: Napoli
city: Pontedera
country: Italy
facility: Ospedale "Felice Lotti" Di Pontedera ( Site 1311)
state: Pisa
city: Bari
country: Italy
facility: A.O.U.C. Policlinico di Bari ( Site 1306)
state: Puglia
city: Palermo
country: Italy
facility: Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO-U.O.S.D. Malattie Infiammatorie Croniche Intestinali ( Site 1302)
state: Sicilia
city: Negrar Di Valpolicella
country: Italy
facility: Ospedale Sacro Cuore Don G. Calabria-IBD Unit ( Site 1303)
state: Verona
city: Bologna
country: Italy
facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1308)
city: Messina
country: Italy
facility: Azienda Ospedaliera Universitaria Di Messina G. Martino ( Site 1314)
city: Milano
country: Italy
facility: Ospedale San Raffaele-Gastroenterology and Gastrointestinal Endoscopy ( Site 1300)
city: Roma
country: Italy
facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Dipartimento di Medicina Interna e Gas ( Site 1312)
city: Nagakute
country: Japan
facility: Aichi Medical University Hospital ( Site 3429)
state: Aichi
city: Nagoya,
country: Japan
facility: Nagoya University Hospital ( Site 3445)
state: Aichi
city: Nagoya
country: Japan
facility: Nagoya City University Hospital ( Site 3446)
state: Aichi
city: Abiko
country: Japan
facility: Tokatsu Tsujinaka Hospital ( Site 3403)
state: Chiba
city: Kashiwa
country: Japan
facility: Tsujinaka Hospital - Kashiwanoha ( Site 3402)
state: Chiba
city: Sakura
country: Japan
facility: Toho University Sakura Medical Center ( Site 3413)
state: Chiba
city: Kurume
country: Japan
facility: Kurume University Hospital ( Site 3419)
state: Fukuoka
city: Maebashi
country: Japan
facility: Gunma University Hospital ( Site 3432)
state: Gunma
city: Fukuyama
country: Japan
facility: National Hospital Organization Fukuyama Medical Center ( Site 3442)
state: Hiroshima
city: Sapporo
country: Japan
facility: Sapporo Tokushukai Hospital ( Site 3427)
state: Hokkaido
city: Sapporo
country: Japan
facility: Sapporo Medical University Hospital ( Site 3460)
state: Hokkaido
city: Sapporo
country: Japan
facility: Medical Corporation Sapporo IBD Clinic ( Site 3420)
state: Hokkaido
city: Sapporo
country: Japan
facility: Sapporohigashi Tokushukai Hospital ( Site 3441)
state: Hokkaido
city: Nishinomiya
country: Japan
facility: Hyogo Medical University Hospital ( Site 3430)
state: Hyogo
city: Hitachi
country: Japan
facility: Hitachi General Hospital ( Site 3438)
state: Ibaraki
city: Kanazawa
country: Japan
facility: Kanazawa University Hospital ( Site 3436)
state: Ishikawa
city: Morioka
country: Japan
facility: Iwate Medical University Uchimaru Medical Center ( Site 3457)
state: Iwate
city: Kamakura
country: Japan
facility: Gokeikai Ofuna Chuo Hospital ( Site 3412)
state: Kanagawa
city: Kawasaki
country: Japan
facility: St. Marianna University Hospital ( Site 3440)
state: Kanagawa
city: Yokohama
country: Japan
facility: Matsushima Hospital ( Site 3450)
state: Kanagawa
city: Yokohama
country: Japan
facility: Yokohama City University Medical Center ( Site 3439)
state: Kanagawa
city: Tsu
country: Japan
facility: Mie University Hospital ( Site 3405)
state: Mie
city: Sendai
country: Japan
facility: Tohoku University Hospital ( Site 3447)
state: Miyagi
city: Ginowan
country: Japan
facility: University of the Ryukyus Hospital ( Site 3459)
state: Okinawa
city: Hirakata
country: Japan
facility: Kansai Medical University Hospital ( Site 3409)
state: Osaka
city: Kawagoe
country: Japan
facility: Saitama Medical Center ( Site 3452)
state: Saitama
city: Hamamatsu
country: Japan
facility: Hamamatsu University Hospital ( Site 3449)
state: Shizuoka
city: Hamamatsu
country: Japan
facility: Matsuda Hospital ( Site 3404)
state: Shizuoka
city: Shimizu
country: Japan
facility: National Hospital Organization Shizuoka Medical Center ( Site 3401)
state: Shizuoka
city: Bunkyō
country: Japan
facility: Institute of Science Tokyo Hospital ( Site 3437)
state: Tokyo
city: Chuo
country: Japan
facility: Ginza Central Clinic ( Site 3407)
state: Tokyo
city: Minato
country: Japan
facility: Kitasato University Kitasato Institute Hospital ( Site 3458)
state: Tokyo
city: Mitaka
country: Japan
facility: Kyorin University Hospital ( Site 3443)
state: Tokyo
city: Mitato
country: Japan
facility: The Jikei University Hospital ( Site 3414)
state: Tokyo
city: Shinjuku
country: Japan
facility: Tokyo Medical University Hospital ( Site 3456)
state: Tokyo
city: Shinjuku
country: Japan
facility: National Center for Global Health and Medicine ( Site 3423)
state: Tokyo
city: Kofu
country: Japan
facility: Yamanashi Prefectural Central Hospital ( Site 3435)
state: Yamanashi
city: Fukuoka
country: Japan
facility: Fukuoka University Hospital ( Site 3417)
city: Hiroshima
country: Japan
facility: Hiroshima University Hospital ( Site 3418)
city: Kagoshima
country: Japan
facility: Kagoshima University Hospital ( Site 3425)
city: Kagoshima
country: Japan
facility: Kagoshima IBD Gastroenterology Clinic ( Site 3428)
city: Kyoto
country: Japan
facility: University Hospital,Kyoto Prefectural University of Medicine ( Site 3406)
city: Kyoto
country: Japan
facility: National Hospital Organization Kyoto Medical Center ( Site 3411)
city: Okayama
country: Japan
facility: Okayama University Hospital ( Site 3454)
city: Osaka
country: Japan
facility: Infusion Clinic ( Site 3408)
city: Osaka
country: Japan
facility: National Hospital Organization Osaka National Hospital ( Site 3453)
city: Saga
country: Japan
facility: Saga University Hospital ( Site 3424)
city: Tokyo
country: Japan
facility: Tokyo Yamate Medical Center ( Site 3415)
city: Toyama
country: Japan
facility: Toyama Prefectural Central Hospital ( Site 3410)
city: Yamagata
country: Japan
facility: Yamagata University Hospital ( Site 3426)
city: Wonju
country: Korea, Republic of
facility: Wonju Severance Christian Hospital-Internal Medicine ( Site 3600)
state: Kang-won-do
city: Suwon-si
country: Korea, Republic of
facility: The Catholic University Of Korea St. Vincent's Hospital-Gastroenterology ( Site 3608)
state: Kyonggi-do
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital ( Site 3601)
state: Pusan-Kwangyokshi
city: Haeundae-gu
country: Korea, Republic of
facility: Inje University Haeundae Paik Hospital ( Site 3605)
state: Pusan-Kwangyokshi
city: Dongjak-gu
country: Korea, Republic of
facility: Chung-Ang University Hospital ( Site 3606)
state: Seoul
city: Daegu
country: Korea, Republic of
facility: Yeungnam Univeristy Medical Center ( Site 3610)
state: Taegu-Kwangyokshi
city: Daejeon
country: Korea, Republic of
facility: The Catholic University of Korea, Daejeon St. Mary's Hospital ( Site 3604)
state: Taejon-Kwangyokshi
city: Seoul
country: Korea, Republic of
facility: Kyung Hee University Hospital ( Site 3611)
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital ( Site 3607)
city: Seoul
country: Korea, Republic of
facility: Kangbuk Samsung Hospital-Internal Medicine ( Site 3612)
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea, Eunpyeong St. Mary's Hospital ( Site 3602)
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University Health System-Department of Internal Medicine ( Site 3603)
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center ( Site 3609)
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center ( Site 3613)
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kauno klinikos-Gastroenterology ( Site 6000)
state: Kauno Apskritis
city: Vilnius
country: Lithuania
facility: VILNIUS UNIVERSITY HOSPITAL SANTAROS KLINIKOS-Department of Clinical Trials and Pharmacology ( Site 6001)
city: Johor Bahru
country: Malaysia
facility: Hospital Sultanah Aminah ( Site 6104)
state: Johor
city: Kubang Kerian
country: Malaysia
facility: Hospital Universiti Sains Malaysia ( Site 6103)
state: Kelantan
city: Lembah Pantai
country: Malaysia
facility: University Malaya Medical Centre ( Site 6101)
state: Kuala Lumpur
city: Kuching
country: Malaysia
facility: Sarawak General Hospital ( Site 6102)
state: Sarawak
city: Ampang
country: Malaysia
facility: Hospital Ampang ( Site 6106)
state: Selangor
city: Ciudad de Mexico
country: Mexico
facility: Centro de Investigación y Gastroenterología - S.C. ( Site 3102)
state: Distrito Federal
city: Leon
country: Mexico
facility: Morales Vargas Centro de Investigacion ( Site 3101)
state: Guanajuato
city: Tlajomulco de Zúñiga
country: Mexico
facility: Centro Medico Clinico Quirurgico Especializado en Investigación ( Site 3106)
state: Jalisco
city: San Pedro Garza Garcia
country: Mexico
facility: Servicios de Oncología Médica Integral, S.A de C.V. ( Site 3108)
state: Nuevo Leon
city: Oaxaca de Juarez
country: Mexico
facility: Centro de Investigacion Clinica de Oaxaca ( Site 3105)
state: Oaxaca
city: Merida
country: Mexico
facility: Medical Care and Research SA de CV-GASTROENTEROLOGY ( Site 3110)
state: Yucatan
city: Nijmegen
country: Netherlands
facility: Radboudumc ( Site 1505)
state: Gelderland
city: Tilburg
country: Netherlands
facility: ETZ Elisabeth ( Site 1501)
state: Noord-Brabant
city: Uden
country: Netherlands
facility: Ziekenhuis Bernhoven ( Site 1508)
state: Noord-Brabant
city: Amsterdam
country: Netherlands
facility: Amsterdam UMC, locatie VUmc-IBD Trial Unit ( Site 1500)
state: Noord-Holland
city: Rotterdam
country: Netherlands
facility: Erasmus Medisch Centrum ( Site 1504)
state: Zuid-Holland
city: Rotterdam
country: Netherlands
facility: Franciscus Gasthuis & Vlietland, Locatie Gasthuis ( Site 1503)
state: Zuid-Holland
city: Groningen
country: Netherlands
facility: University Medical Center Groningen ( Site 1506)
city: Utrecht
country: Netherlands
facility: Universitair Medisch Centrum Utrecht ( Site 1502)
city: Dunedin
country: New Zealand
facility: Dunedin Hospital ( Site 3505)
state: Otago
city: Lower Hutt
country: New Zealand
facility: Hutt Valley District Health board HVDHB ( Site 3500)
state: Wellington
city: Auckland
country: New Zealand
facility: Aotearoa Clinical Trials ( Site 3501)
city: Lima
country: Peru
facility: Investigaciones Clínicas / Instituto de Ginecología y Reproducción ( Site 3002)
city: Lima
country: Peru
facility: Hospital Cayetano Heredia ( Site 3003)
city: Jelenia Gora
country: Poland
facility: Amicare ( Site 1620)
state: Dolnoslaskie
city: Wroclaw
country: Poland
facility: Planetmed ( Site 1600)
state: Dolnoslaskie
city: Wroclaw
country: Poland
facility: Melita Medical ( Site 1607)
state: Dolnoslaskie
city: Wroclaw
country: Poland
facility: EMC Instytut Medyczny SA ( Site 1601)
state: Dolnoslaskie
city: Torun
country: Poland
facility: Gastromed Sp. z o. o. ( Site 1619)
state: Kujawsko-pomorskie
city: Lodz
country: Poland
facility: Centrum Medyczne Med-Gastr Sp. z o.o. ( Site 1616)
state: Lodzkie
city: Lodz
country: Poland
facility: AmiCare Sp. z o.o. Sp. k. ( Site 1608)
state: Lodzkie
city: Nowy Targ
country: Poland
facility: Allmedica ( Site 1602)
state: Malopolskie
city: Warszawa
country: Poland
facility: Centrum Zdrowia MDM ( Site 1618)
state: Mazowieckie
city: Warszawa
country: Poland
facility: WIP Warsaw IBD Point Profesor Kierkuś ( Site 1622)
state: Mazowieckie
city: Tychy
country: Poland
facility: H-T Centrum Medyczne Endoterapia ( Site 1610)
state: Slaskie
city: Poznan
country: Poland
facility: PL Certus ( Site 1605)
state: Wielkopolskie
city: Poznań
country: Poland
facility: Pratia Poznań ( Site 1603)
state: Wielkopolskie
city: Szczecin
country: Poland
facility: Twoja Przychodnia - Szczecinskie Centrum Medyczne ( Site 1612)
state: Zachodniopomorskie
city: Szczecin
country: Poland
facility: Sonomed Sp. z o. o. ( Site 1617)
state: Zachodniopomorskie
city: Guimaraes
country: Portugal
facility: Unidade Local de Saúde do Alto Ave - Hospital Senhora da Oliveira ( Site 1704)
state: Braga
city: Portimão
country: Portugal
facility: Unidade Local de Saude do Algarve - Hospital de Portimão ( Site 1700)
state: Faro
city: Leiria
country: Portugal
facility: Unidade Local de Saude da Região de Leiria - Hospital Santo André ( Site 1706)
city: Lisboa
country: Portugal
facility: Hospital da Luz Lisboa ( Site 1707)
city: Lisboa
country: Portugal
facility: Hospital dos Lusíadas Lisboa ( Site 1701)
city: Viana do Castelo
country: Portugal
facility: ULSAM - Hospital de Santa Luzia ( Site 1703)
city: Viseu
country: Portugal
facility: Unidade Local de Saude Dão-Lafões - Hospital de São Teotónio ( Site 1702)
city: Bucharest
country: Romania
facility: MEMORIAL HEALTHCARE INTERNATIONAL S.R.L ( Site 1806)
state: Bucuresti
city: București
country: Romania
facility: Fundeni Clinical Institute-Gastroenterology and Hepatology Center ( Site 1808)
state: Bucuresti
city: Cluj-Napoca
country: Romania
facility: GastroMed ( Site 1809)
state: Cluj
city: Targu Mures
country: Romania
facility: Spitalul Clinic Judetean Mures-Gastroenterology ( Site 1807)
state: Mures
city: Timisoara
country: Romania
facility: ASOCIATIA ONCOHELP ( Site 1805)
state: Timis
city: Bucuresti
country: Romania
facility: S.C. Centrul Medical Medicum SRL-Gastroenterology ( Site 1804)
city: Belgrade
country: Serbia
facility: Clinical Hospital Center Zvezdara-Gastroenterology and hepatology Department ( Site 1903)
state: Beograd
city: Zrenjanin
country: Serbia
facility: General Hospital "Djordje Joanovic" ( Site 1905)
state: Srednjebanatski Okrug
city: Singapore
country: Singapore
facility: Singapore General Hospital ( Site 6202)
state: Central Singapore
city: Singapore
country: Singapore
facility: Tan Tock Seng Hospital-Gastroenterology and Hepatology ( Site 6201)
state: Central Singapore
city: Singapore
country: Singapore
facility: Changi General Hospital ( Site 6203)
state: South East
city: Banska Bystrica
country: Slovakia
facility: Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica-Gastroenterologicke oddelenie ( Site 2002)
state: Banskobystricky Kraj
city: Bratislava
country: Slovakia
facility: Cliniq s.r.o. ( Site 2001)
state: Bratislavsky Kraj
city: Nitra
country: Slovakia
facility: KM Management ( Site 2000)
state: Nitriansky Kraj
city: Presov
country: Slovakia
facility: GASTRO I ( Site 2004)
state: Presovsky Kraj
city: Presov
country: Slovakia
facility: Gastro LM ( Site 2005)
state: Presovsky Kraj
city: Cape Town
country: South Africa
facility: Panorama Medical Centre ( Site 4001)
state: Western Cape
city: Cape Town
country: South Africa
facility: Spoke Research ( Site 4003)
state: Western Cape
city: Cape Town
country: South Africa
facility: Life Kingsbury Hospital ( Site 4000)
state: Western Cape
city: Plumstead
country: South Africa
facility: Private Practice - Dr. M.N. Rajabally ( Site 4007)
state: Western Cape
city: Badalona
country: Spain
facility: Hospital Germans Trias i Pujol ( Site 2101)
state: Barcelona
city: Barcelona
country: Spain
facility: HOSPITAL CLÍNIC DE BARCELONA-ICMDM - Clinical Institute of Digestive and Metabolic Diseases ( Site 2112)
state: Cataluna
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro ( Site 2102)
state: Madrid
city: Torrejón de Ardoz
country: Spain
facility: Hospital Universitario de Torrejón ( Site 2108)
state: Madrid
city: Madrid
country: Spain
facility: Hospital Universitario La Paz ( Site 2100)
city: Pontevedra
country: Spain
facility: Hospital Montecelo. Complexo Hospitalario de Pontevedra ( Site 2107)
city: Santa Cruz de Tenerife
country: Spain
facility: Hospital Universitario Nuestra Senora de la Candelaria ( Site 2105)
city: Valencia
country: Spain
facility: HOSPITAL CLINICO DE VALENCIA-MEDICINA DIGESTIVA ( Site 2103)
city: Valencia
country: Spain
facility: Hospital Universitari i Politecnic La Fe ( Site 2111)
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet ( Site 2104)
city: Linköping
country: Sweden
facility: Universitetssjukhuset i Linköping ( Site 5502)
state: Ostergotlands Lan
city: Danderyd
country: Sweden
facility: Danderyds Sjukhus ( Site 5501)
state: Stockholms Lan
city: Stockholm
country: Sweden
facility: Karolinska Universitetssjukhuset Solna ( Site 5500)
state: Stockholms Lan
city: Basel
country: Switzerland
facility: University Hospital Basel-Gastroenterology and Hepatology ( Site 2204)
state: Basel-Stadt
city: Bern
country: Switzerland
facility: INTESTO-Gastroenterologische Praxis / Crohn-Colitis Zentrum Bern ( Site 2202)
state: Berne
city: St.Gallen
country: Switzerland
facility: Cantonal Hospital St.Gallen-Klinik für Gastroenterologie / Hepatologie ( Site 2201)
state: Sankt Gallen
city: Zürich
country: Switzerland
facility: UniversitätsSpital Zürich-Gastroenterologie & Hepatologie ( Site 2200)
state: Zurich
city: Zhu Bei City
country: Taiwan
facility: National Taiwan University BioMedical Park Hospital ( Site 3702)
state: Hsinchu
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital-Internal Medicine ( Site 3700)
city: Taoyuan
country: Taiwan
facility: Chang Gung Medical Foundation-Linkou Branch ( Site 3701)
city: Ankara
country: Turkey
facility: Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 2300)
city: Ankara
country: Turkey
facility: ANKARA UNIVERSITY IBNI SINA HOSPITAL-Gastroenterology ( Site 2303)
city: Ankara
country: Turkey
facility: Ankara Bilkent Şehir Hastanesi-Gastroenterology ( Site 2301)
city: Antalya
country: Turkey
facility: Antalya Egitim ve Arastırma Hastanesi ( Site 2304)
city: Istanbul
country: Turkey
facility: Istanbul Universitesi Cerrahpasa Tip Fakultesi Hastanesi ( Site 2306)
city: Istanbul
country: Turkey
facility: Marmara Univetsitesi Pendik Egitim ve Arastirma Hastanesi ( Site 2305)
city: İzmir
country: Turkey
facility: Ege Universitesi Hastanesi ( Site 2302)
city: Ivano-Frankivsk
country: Ukraine
facility: Communal non-profit enterprise "Regional clinical hospital of Ivano-Frankivsk Regional Council" ( Site 5815)
state: Ivano-Frankivska Oblast
city: Kyiv
country: Ukraine
facility: Medical Center of Limited ( Site 5806)
state: Kyivska Oblast
city: Kyiv
country: Ukraine
facility: Center of Family Medicine Plus ( Site 5803)
state: Kyivska Oblast
city: Lviv
country: Ukraine
facility: Communal Non-profit Enterprise of Lviv Regional Council "Lviv Regional Clinical Hospital"-proctology ( Site 5809)
state: Lvivska Oblast
city: Vinnytsia
country: Ukraine
facility: Limited liability company "Medical center Health Clinic" ( Site 5807)
state: Vinnytska Oblast
city: Vinnytsia
country: Ukraine
facility: Clinic of Scientific and Research Institute of Invalid Rehabilitation of VNMU n.a. M.I.Pyrohov ( Site 5812)
state: Vinnytska Oblast
city: Vinnytsia
country: Ukraine
facility: Communal Non-Commercial Enterprise "Vinnytsia City Clinical -Clinical Therapeutic Department #1 ( Site 5811)
state: Vinnytska Oblast
city: Vinnytsya
country: Ukraine
facility: Municipal Nonprofit Enterprise "Vinnytsia Regional Clinical Hospital n.a. M. I. Pyrohov of Vinnytsia ( Site 5814)
state: Vinnytska Oblast
city: Lutsk
country: Ukraine
facility: Municipal Enterprise "Volyn Regional Clinical Hospital" of Volyn Regional Council ( Site 5813)
state: Volynska Oblast
city: Kyiv
country: Ukraine
facility: Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal" ( Site 5800)
city: Kyiv
country: Ukraine
facility: Dobrobut Medical Center ( Site 5801)
city: Kyiv
country: Ukraine
facility: Medical Center of Private Enterprise "Sygma" ( Site 5808)
city: Exeter
country: United Kingdom
facility: Royal Devon & Exeter Hospital ... ( Site 2407)
state: Devon
city: Doncaster
country: United Kingdom
facility: Doncaster Royal Infirmary ( Site 2401)
state: England
city: Huddersfield
country: United Kingdom
facility: Huddersfield Royal Infirmary ( Site 2409)
state: England
city: London
country: United Kingdom
facility: Whipps Cross University Hospital-Clinical Research Unit ( Site 2404)
state: England
city: London
country: United Kingdom
facility: University College London Hospital-Clinical Research Facility ( Site 2405)
state: London, City Of
city: Oxford
country: United Kingdom
facility: The John Radcliffe Hospital ( Site 2406)
state: Oxfordshire
city: Bristol
country: United Kingdom
facility: Southmead Hospital ( Site 2403)
state: South Gloucestershire
city: West Midlands
country: United Kingdom
facility: Walsall Manor Hospital ( Site 2410)
state: Walsall
Study officials:
affiliation: Merck Sharp & Dohme LLC
name: Medical Director
role: STUDY_DIRECTOR
References: