Clinical trial NCT04455425: Acquired Syphlis by Non Sexual Contact
Official title: Descriptive Cohort of Acquired Syphlis by Non Sexual Contact
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Syphilis Acquired
Syphilis Infection
Lead sponsor: Hospital de Niños R. Gutierrez de Buenos Aires
Sponsor class: OTHER
First posted: 2020-07-02
Enrollment: 24
Sex: ALL
Minimum age (years): 0
Maximum age (years): 18
Standard ages: CHILD
ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children from 0 to 18 years of age assisted at Parasitoloy and Chagas department from Children's Hospital in Buenos Aires, Argentina

Brief summary: Syphilis is classically described as a sexually transmitted disease. As this source of contagious has been described long ago -mainly though by observation- when children presents with acquired syphilis, child abuse is always considered and must be ruled out by specialists in a careful evaluation.

However, muco-cutaneous lesions can be a contagious source for congenital syphilis; therefore the possibility of non-sexual transmission through intimate contact with infected people through humid lesions (such as in kisses, breastfeeding, food-handling) or contaminated fomites (towels, bed sheets, underwear, cups, pacifiers, cutlery) could be considered. Experts worldwide have observed this non-sexual transmission, as described in many reports in literature.

The investigators will study retrospectively patients from a cohort with non-sexual transmission. The diagnosis criteria used for acquired syphilis were as follows: age under 18 years with treponemic and nontreponemic positive tests, secondary-syphilis suspicious lesions and negative maternal syphilis serology. Nonsexual contagious was defined as contacts without physical and psychosocial indicators of sexual abuse according to current guides. In this cohort, in every case a psychosocial evaluation was completed with a written report in order to evaluate sexual contact probability.

The teamo will describe these patients clinical and laboratory findings, family and close acquaintances serologies and probable source of contagious.


Eligibility criteria: INCLUSION CRITERIA:

- Children with treponemic and non-treponemic positive tests with primary or secondary-syphilis suspicious lesions

EXCLUSION CRITERIA:

- Children with diagnose criteria positive for Congenital syphilis

Primary outcomes:
measure: Describe diagnose process of a cohort of children with assumed non-sexual acquired syphilis
timeFrame: Past 20 years
measure: Describe serology titers from patients with non - sexually acquired syphilis and from their close contacts
timeFrame: Past 20 years
measure: Describe reported symptoms and physical findings at diagnose and during follow-up f children with assumed non-sexual acquired syphilis and their close contacts
timeFrame: Past 20 years
Secondary outcomes:
Other outcomes:
Locations:
city: Buenos Aires
country: Argentina
facility: Hospital de Niños Ricardo Gutierrez
state: Capital Federal
Study officials:
affiliation: Principal Investigator
name: Guillermo Moscatelli, MD
role: PRINCIPAL_INVESTIGATOR
References: