Clinical trial NCT01799148: Air Pollution, Inflammation and Acute Coronary Syndrome
Official title: Impact of AIR Pollution on Inflammation, Oxidative Stress and 1-year Prognosis in Patients Hospitalized for Acute COronary Syndrome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Patients With Acute Coronary Syndrome
Keywords: Acute coronary syndrome
Air pollution.
Inflammation.
Oxidative Stress.
Prognosis
Lead sponsor: Fundación Canaria Rafael Clavijo para la Investigación Biomédica
Sponsor class: OTHER
First posted: 2013-02-26
Enrollment: 307
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Cohort of consecutive patients admitted with diagnosis of aucte coronary, which will quantify the exposure of particulate air pollutants 24 hours a day 7 days earlier prior to admission. Also be determined inflammatory molecules and oxidative stress in admission. During the evolution of these patients, after 30 days, 6 and 12 months will recorded major adverse cardiovascular events. It also will quantify the exposure of air pollutant particles, in all patients included at 30 days, 6 and 12 months.

Brief summary: The objectives of this study are: 1) To determine whether patients with acute coronary syndrome, the level of environmental exposure to particulate air pollutants in the week prior to admission, are related to concentrations of inflammatory molecules and oxidative stress. 2) To investigate whether the level of environmental exposure is an independent prognostic factor in terms of overall and cardiovascular mortality, myocardial infarction or unstable angina at 30 days, 6 and 12 months.


Eligibility criteria: Inclusion Criteria:

* Patients with acute coronary syndrome

Exclusion Criteria:

* Infectious process and / or local or systemic inflammation in the 15 days before admission.
* Thyrotoxicosis.
* Neoplasms - or any other disease that seriously compromise the prognosis of life and / or generate a systemic inflammatory response.

Primary outcomes:
measure: Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome.
timeFrame: 7 days
Secondary outcomes:
measure: Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome.
timeFrame: 1 year
Other outcomes:
measure: Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome:
timeFrame: 1 year
Locations:
city: La Laguna
country: Spain
facility: Hospital Universitario de Canarias
state: Santa Cruz de Tenerife
Study officials:
References:
citation: Dominguez-Rodriguez A, Rodriguez S, Abreu-Gonzalez P, Avanzas P. [Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome: design of the AIRACOS study]. Med Clin (Barc). 2013 Dec 21;141(12):529-32. doi: 10.1016/j.medcli.2013.05.024. Epub 2013 Jul 25. No abstract available. Spanish.