Clinical trial NCT06957262: Effects of Surgical Correction of Nasal Obstruction on Oxygen Uptake and Ventilation Volume
Official title: Effects of Surgical Correction of Nasal Obstruction on Oxygen Uptake and Ventilation Volume
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nasal Obstruction
Septoplasty Surgeries
Athletic Performance
Keywords: nasal surgery
aerobic performance
exercise economy
respiratory work
Lead sponsor: Akdeniz University
Sponsor class: OTHER
Collaborators: name: Akdeniz University, Scientific Research Projects Coordination Unit
First posted: 2025-05-04
Enrollment: 22
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants were assigned to one of two parallel groups: an experimental group consisting of athletes with nasal obstruction undergoing septoplasty, and a control group of matched athletes without nasal obstruction who did not receive any intervention. Both groups underwent the same aerobic performance evaluations at baseline and at follow-up (2-3 months).
Primary purpose: TREATMENT

Brief summary: This retrospective study aims to evaluate the effect of surgical correction of nasal obstruction on aerobic performance parameters in male athletes aged 20-32 years. The main questions it aims to answer are:

* Does nasal obstruction surgery impact running economy and ventilation during exercise?
* Does it affect oxygen consumption during submaximal running efforts?

Researchers will retrospectively compare male athletes who underwent nasal obstruction surgery (experimental group) to matched athletes without nasal obstruction (control group) to assess changes in respiratory function and exercise performance.

Participants were assessed by:

* Acoustic rhinometry to measure nasal cavity dimensions.
* The Nasal Obstruction Symptom Evaluation (NOSE) scale and Epworth Sleepiness Scale (ESS) to evaluate nasal obstruction symptoms and daytime sleepiness.
* Incremental treadmill exercise tests to collect data on gas exchange, oxygen consumption, ventilation, and running economy before and after the surgical intervention (or across a similar time period for the control group).


Eligibility criteria: Inclusion Criteria:

For Experimental Group (EG):

* Diagnosed with nasal obstruction due to septal deviation and/or inferior turbinate hypertrophy
* Experiencing nasal breathing difficulties and sleep disturbance
* Deemed eligible for septoplasty and/or inferior turbinoplasty following physical and endoscopic examination
* Voluntarily agreed to participate in the study
* For Control Group (CG):
* No reported nasal obstruction or breathing complications
* Matched with EG participants by age, sport discipline, training level, and VO₂max (with a maximum variation of ±5%)
* Willing to follow a similar training program to their matched EG counterparts between pre- and post-testing periods

Exclusion Criteria:

* History of nasal surgery
* Presence of cardiopulmonary diseases
* Musculoskeletal disorders affecting physical performance or exercise testing
* Inability or unwillingness to follow the pre- and post-test training schedule
* Any surgical complication that would interfere with post-operative participation in physical testing (note: none occurred in this study)

Primary outcomes:
measure: Change in Running Economy (ml/kg/min)
timeFrame: Baseline and 2-3 months post-surgery
Secondary outcomes:
measure: Change in Oxygen Consumption (VO₂ max and submax VO₂)
timeFrame: Baseline and 2-3 months post-surgery
measure: Change in Ventilation
timeFrame: Baseline and 2-3 months post-surgery
Other outcomes:
Locations:
Study officials:
affiliation: Akdeniz University Faculty of Sport Sciences
name: Tuba Melekoğlu, Phd
role: PRINCIPAL_INVESTIGATOR
References: