louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06318780: Concordance of Three Imaging Methods by Dynamic CT, Contrast Ultrasound and CT Angiography in the Characterization of Endoleaks in Patients With an Aortic Endoprosthesis
Official title: Concordance of Three Imaging Methods by Dynamic CT, Contrast Ultrasound and CT Angiography in the Characterization of Endoleaks in Patients With an Aortic Endoprosthesis
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Aortic Diseases
Keywords: EVAR
d-CTA
CEUS
Lead sponsor: Centre Hospitalier Universitaire, Amiens
Sponsor class: OTHER
First posted: 2024-03-19
Enrollment: 69
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Among patients who have undergone EVAR, there is a significant risk of 20-50% endoleak. These endoleaks often require secondary interventions to reduce the risk of expansion or rupture. Currently, three-phase CT angiography and CEUS ultrasound are recommended in the post-operative monitoring of EVAR but these remain limited in characterizing the type and source of endoleak. In this study the investigators will study the interest of d-CTA for a better detection and characterization of endoleaks.


Eligibility criteria: Inclusion Criteria:

* Patients 18 years of age and older,
* Patients who have received EVAR ,
* Detection of endoleak and/or with an aneurysmal sac enlargement greater than or equal to 5 mm over 6 months.

Exclusion Criteria:

* Minor patients,
* absence of endoleak and growth of the aneurysmal sac (greater than or equal to 5 mm over 6 months),
* patient under guardianship, curators, safeguard of justice,
* patient deprived of liberty,
* pregnant woman
* Patient who does not benefit from a social security scheme

Primary outcomes:
measure: Endoleak classification using the CT angiography
timeFrame: 5 years
measure: Variation of Endoleak classification between CEUS ultrasound and the CT angiography
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Amiens
country: France
facility: CHU Amiens Picardie
state: Picardie
Study officials:
References:
Clinical trial NCT01325480: High Septal Pacing for Cardiac Resynchronization Therapy
Official title: High Septal Pacing for Cardiac Resynchronization Therapy Acute Research Study
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Heart Failure
Left Bundle Branch Block
Heart Disease
Keywords: Cardiac Resynchronization Therapy
Pacing
His Bundle
Lead sponsor: Boston Scientific Corporation
Sponsor class: INDUSTRY
First posted: 2011-03-29
Enrollment: 15
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Heart failure patients with wide QRS and undergoing a CRT procedure

Brief summary: The purpose of this acute study is to perform a preliminary investigation of high septal right ventricular pacing in the vicinity of the His bundle region as an alternate or adjunctive means for cardiac resynchronization in patients with heart failure and wide QRS.

Detailed description: The HISTORY Study is an acute, cross-sectional, multi-center, feasibility study with a randomized within patient test sequence designed to characterize the effects of high septal right ventricular pacing in the vicinity of the His bundle region compared to conventional biventricular pacing for cardiac resynchronization therapy.

Eligibility criteria: Inclusion Criteria:

* 50 years of age or older
* Patients willing and capable of providing informed consent, participating in all testing associated with this clinical investigation
* Patients undergoing a CRT implant procedure (pacemaker or defibrillator) for one of the following reasons

  * Indicated for a new device
  * Device upgrade
  * Device replacement
  * Lead revision
* Note: recognized indications for CRT-P and CRT-D as of October 2009 are valid for inclusion in this study. Should new indications become approved during the study conduct; those will also be applied within the inclusion criteria.

Exclusion Criteria:

* Patients unwilling or incapable of signing the informed consent, or patients having previously withdrawn their consent
* Patients in AF that cannot be cardioverted for the study
* RBBB pattern
* Sustained, uncontrolled ventricular tachycardia
* Sinus rhythm \< 30 bpm or \>100 bpm
* Complete AV node block
* Second degree AV block
* Women who are pregnant or plan to become pregnant during the study (method of assessment upon physician's discretion);
* History of (hemorrhagic) cerebro-vascular accident or TIA

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital
Study officials:
References:
Clinical trial NCT04376580: Use of the Nasal Cannula During COVID-19
Official title: Incidence and Implications With the Use of Nasal Cannulas During COVID-19
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: COVID 19
Keywords: Low flow nasal cannula
Anesthesia
Sedation
Regional Anesthesia
Lead sponsor: Tiva Group
Sponsor class: OTHER
First posted: 2020-05-06
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All physician

Brief summary: The objective of this investigation is to determine the incidence of the use of the low flow nasal cannula in suspected or confirmed cases with Covid-19

Detailed description: An anonymous questionnaire will be sent to a group of anesthesiologists via email which will allow to collect information about the use, or not, of the low flow nasal cannula, the type of procedure where it is used, and the type of personal protection weared.

Eligibility criteria: Inclusion Criteria:

* only for physicians

Exclusion Criteria:

* not physicians

Primary outcomes:
measure: Number of physician using los flow nasal cannula during COVID 19 pandemia
timeFrame: 1 month
Secondary outcomes:
measure: Number of physician getting sick during Covid 19 pandemic
timeFrame: 1 month
Other outcomes:
Locations:
city: Buenos Aires
country: Argentina
facility: Carolina Frederico
state: Caba
Study officials:
References:
Clinical trial NCT02560480: Groin Injuries in Finnish Contact Sports
Official title: Groin Injuries in Finnish Contact Sports: Prospective 2-year Clinical and Magnetic Resonance Imaging Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Groin Injury
Keywords: groin pain, groin injury, magnetic resonance imaging
Lead sponsor: Kuopio University Hospital
Sponsor class: OTHER
Collaborators: name: Orton Orthopaedic Hospital
name: Mikkeli Central Hospital
name: Rigshospitalet, Denmark
First posted: 2015-09-25
Enrollment: 200
Sex: MALE
Minimum age (years): 16
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: three contact sport teams (male ice-hockey, soccer, bandy)

Brief summary: The prevalence of acute and chronic groin injuries in athletes is between 5 and 10 %. This observational case-control study follows three contact sport teams (soccer, ice-hockey and bandy) for two years to find out the prevalence and reasons for groin pain. Clinical examination, pain scores and pelvic magnetic resonance imaging (MRI) are performed. Hip and groin questionnaire (HAGOS) is used to determine severity of groin injuries.

Detailed description: The prevalence of chronic groin pain in athletes and physically active adults is between 5 and 10 %. Common causes include adductor tendonitis, musculus rectus abdominis tendopathy, osteitis pubis (edema on MRI scans at pubic symphysis) or disruption of the posterior wall of inguinal canal or iliopsoas muscle. This observational case-control study follows three contact sports team (male soccer, ice-hockey and bandy) for two years to find out prevalence of acute and chronic groin pain. Adult (\>18 years old) male athletes with acute or chronic groin pain during the study pediod are included. Outcome measures are clinical examination, pain scores, exact diagnosis and repeated pelvic MRI (two times) are performed in each patients and three control atheletes in each team. Hip and groin questionnaire (HAGOS) is used to determine the severity of groin injuries. The end-points of study are prevalence of groin injuries and exact diagnosis.

Eligibility criteria: Inclusion Criteria:

* acute (1-30 days) groin injury
* subacute or chronic groin injury (lasting \>30 days)
* pain in the groin or hip area

Exclusion Criteria:

* inguinal hernia
* postoperative pain
* metallic plates or screws in the pelvis (MRI impossible)

Primary outcomes:
measure: prevalence of acute groin injury
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Kuopio
country: Finland
facility: Kuopio University Hospital
Study officials:
affiliation: Department of Surgery, Kuopio Iniversity Hospital, Finland
name: Hannu EK Paajanen, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Paajanen H, Hermunen H, Ristolainen L, Branci S. Long-standing groin pain in contact sports: a prospective case-control and MRI study. BMJ Open Sport Exerc Med. 2019 Mar 19;5(1):e000507. doi: 10.1136/bmjsem-2018-000507. eCollection 2019.
Clinical trial NCT01166880: A Pilot Study Using Laser Speckle Imaging of Neonate Cerebral Vasculature
Official title: Imaging of Neonate Cerebral Vasculature
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Newborn Distress
Keywords: assessment
Lead sponsor: University of California, Irvine
Sponsor class: OTHER
Collaborators: name: Children's Hospital of Orange County
First posted: 2010-07-21
Enrollment: 0
Sex: ALL
Minimum age (years): 1
Maximum age (years): 1
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: new born

Brief summary: The researcher want to know whether reflections of light can be used to provide real-time pictures of blood vessel formation around infants' heads. This approach is called laser speckle imaging

Detailed description: This study involves imaging of superficial blood vessels in the infant's head. Analysis of reflected light images provides the type of data necessary to see the blood vessels.

The researcher want to assess only feasibility of our instrument. If we determine that our instrument has sufficient spatial resolution to image directly large vessels, then we will proceed with plans for a larger study with statistical power.

Eligibility criteria: Inclusion Criteria:

* newborn

Exclusion Criteria:

* non-new bron

Primary outcomes:
measure: Neonate Cerebral Blood Flow
timeFrame: 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Beckman Laser Institute University of California Irvine
name: Bernard Choi, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03284580: Effectiveness of a Home-based Ergonomic Intervention Program in Caregivers of Chronic Post-stroke Patients
Official title: Effectiveness of a Home-based Ergonomic Intervention Program on Overall Quality of Life, Health Satisfaction, and Home Ergonomics in Caregivers of Chronic Post-stroke Patients: a Randomized Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke
Quality of Life
Lead sponsor: Universidad de Granada
Sponsor class: OTHER
First posted: 2017-09-15
Enrollment: 33
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of the present study is to evaluate the effectiveness of two home-based ergonomic intervention programs compared to a control group on the quality of life of caregivers of post-stroke patients

Detailed description: Stroke is a neurological pathology that can cause functional problems and an impairment to perform activities of daily living at home.

For this reason, these patients need the support of a caregiver. Caregivers of post-stroke patients often have also problems with their quality of life because of the care that they must provide. These problems appear mainly during the support tasks in the activities performed at the patient's home.

The objective of the present study is to evaluate the effectiveness of two home-based ergonomic intervention programs compared to a control group on the quality of life of caregivers of post-stroke patients

Eligibility criteria: Inclusion Criteria:

* Being caregivers of post-stroke patients
* Being over 18 years old

Exclusion Criteria:

* Being caregiver of patients with other neurological patients

Primary outcomes:
measure: Change from WhoQol-Bref at 8 weeks
timeFrame: Eight weeks
measure: Change from WhoQol-Bref at 16 weeks
timeFrame: Sixteen weeks
Secondary outcomes:
measure: Change from ergonomic evaluation of the domestic environment at 8 weeks
timeFrame: Eight weeks
measure: Change from ergonomic evaluation of the domestic environment at 16 weeks
timeFrame: Sixteen weeks
Other outcomes:
Locations:
city: Córdoba
country: Spain
facility: José Manuel Pérez Mármol
Study officials:
References:
citation: de Araujo Freitas Moreira KL, Abalos-Medina GM, Villaverde-Gutierrez C, Gomes de Lucena NM, Belmont Correia de Oliveira A, Perez-Marmol JM. Effectiveness of two home ergonomic programs in reducing pain and enhancing quality of life in informal caregivers of post-stroke patients: A pilot randomized controlled clinical trial. Disabil Health J. 2018 Jul;11(3):471-477. doi: 10.1016/j.dhjo.2018.01.003. Epub 2018 Feb 13.
Clinical trial NCT06603480: Effects of Exercise and Metformin on Methylglyoxal Levels in Prediabetic Individuals
Official title: Effects of Exercise and Metformin on Methylglyoxal Levels in Prediabetic Individuals
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Methylglyoxal
PreDiabetes
Exercise
Metformin
Keywords: Physical activity
PreDiabetes
Metformin
Methylglyoxal
Lead sponsor: Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 96
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to compare the effects of exercise, standard lifestyle changes and metformin on MGO in prediabetic individuals.

Detailed description: There is no comparative study in the literature evaluating the effects of exercise and metformin on MGO in prediabetic patients. The aim of this study is to compare the effects of exercise, standard lifestyle changes and metformin on MGO in prediabetic individuals.

Eligibility criteria: Inclusion Criteria:

* Patients who were newly diagnosed with prediabetes by Oral Glucose Tolerance Test (OGTT) and/or HbA1C,
* who were assessed as physically inactive (Level 1) according to the International Physical Activity Questionnaire
* who had sufficient motivation to participate in the exercise program (assessed by one-on-one interviews conducted by the researchers),
* who were deemed suitable to participate in the exercise program after a cardiac examination by a cardiologist (with resting electrocardiogram and questioning of cardiac symptoms, and advanced tests such as exercise electrocardiogram test when necessary),
* who had the same weight (±2.5 kg) for 6 months before participating in the study.

Exclusion Criteria:

* having a serious medical condition that would prevent the person from participating in the exercise study (e.g. advanced malignancy or major neurological, psychiatric or endocrine disease, respiratory failure, etc.),
* having used metformin for 6 months before the study, having cardiovascular disease,
* heart failure, cancer, having a BMI \&lt;19 kg/m2, receiving hormone replacement therapy,
* having a life expectancy of less than 1 year, being HIV positive, substance use,
* functional dependence, having an orthopedic disease that prevents physical activity,
* having cognitive impairment and other diseases that would affect the study results (respiratory diseases, muscle diseases, non-alcoholic fatty liver disease, etc.),
* using medications or supplements that would affect the study results.

Primary outcomes:
measure: MGO
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: Üsküdar
country: Turkey
facility: Sultan 2. Abdülhamid Han Training and Research Hospital
state: İstanbul
Study officials:
References:
Clinical trial NCT01584180: A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. EMCOOLS Brain.Pad (iCOOL 3)
Official title: iCOOL 3 (Induction of COOLing 3): A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. EMCOOLS Brain.Pad
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Ischemic Stroke
Hemorrhagic Stroke
Keywords: hypothermia
induction of hypothermia
cold infusion
local neck cooling
external cooling
surface cooling
non invasive cooling
stroke
intracranial hemorrhage
cerebrovascular disease
neuro intensive care
Lead sponsor: University Hospital Heidelberg
Sponsor class: OTHER
First posted: 2012-04-24
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Mild hypothermia improves outcome in patients with global cerebral ischemia after cardiac arrest. Hypothermia seems promising also in other acute hypoxic-ischemic or in brain swelling associated cerebrovascular disease. The narrow-time-frame is a major issue ("time is brain"). To provide immediate cooling without delay, easy to use, mobile and effective methods are needed. Cold infusions (4 °C) are an accepted standard worldwide. EMCOOLS Brain.Pad (Emergency Medical Cooling Systems AG, Wien, Austria) is a new non-invasive surface cooling system. A comparison of these two induction methods has never been done before. Neither was the effect of the EMCOOLS Brain.Pad on brain-temperature measured. For the first time iCOOL 3 compares feasibility, safety and efficacy of the two methods.


Eligibility criteria: Inclusion Criteria:

* Sedation
* Combined ICP-temperature-probe
* Indication to lower body temperature ≤ 1.5°C
* Age ≥ 18 years

Exclusion Criteria:

* Body weight \> 120 kg
* Severe renal insufficiency
* Acute pulmonary embolism
* Acute myocardial infarction
* High-grade heart valve stenosis or insufficiency
* Severe cardiac insufficiency (NYHA ≥ III)
* Threatening ventricular dysrhythmia
* Cardiac dysrhythmia with bradycardia (heart rate \< 45 /min, QTc \> 450 ms, sick sinus syndrome, AV-block II-III°).
* Known hematologic disease with increased risk of thrombosis (e.g. cryoglobulinemia, cold agglutinins, sickle cell anemia)
* Known vasospastic vascular disorder (e.g. Raynaud's phenomenon or thromboangiitis obliterans)
* Skin lesions not allowing a secure application of the EMCOOLS Brain.Pad

Primary outcomes:
measure: Brain temperature
timeFrame: -15 to +60min
Secondary outcomes:
measure: (Neuro-)vital parameters
timeFrame: -15 to +180 min
measure: Cerebral autoregulation
timeFrame: 15 to +180 min
measure: Safety
timeFrame: 0 - 7 days
Other outcomes:
Locations:
city: Heidelberg
country: Germany
facility: Neuro Intensive Care Unit 2, Dept. of Neurology, University Hospital Heidelberg
Study officials:
affiliation: University Hospital Heidelberg
name: Sven Poli, Dr. med.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03818880: Choroidal Response to Novel Spectacle Lens to Control Myopia Progression
Official title: A Sub-Study to Assess the Choroidal Response to Novel Spectacle Lens to Control Myopia Progression (CHERRY)
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Myopia, Progressive
Keywords: Myopia
Myopia control
Lead sponsor: SightGlass Vision, Inc.
Sponsor class: INDUSTRY
Collaborators: name: University of Waterloo
First posted: 2019-01-28
Enrollment: 10
Sex: ALL
Minimum age (years): 6
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Diurnal variations in the thickness of the choroid have been reported in the literature, and, more recently, the role of the choroid has been studied with respect to its role in myopia (near-sightedness) progression.

Detailed description: Diurnal variations in the thickness of the choroid have been reported in the literature , and, more recently, the role of the choroid has been studied with respect to its role in myopia (near-sightedness) progression. SightGlass Vision, Inc is conducting a multi-site, randomized, controlled, interventional study to confirm the efficacy and safety of spectacle lenses designed to inhibit the progression of myopia by reducing image contrast in peripheral vision. CORE is participating as a clinical site in this three year study which aims to compare changes in ocular length and cycloplegic auto-refraction in children randomised to wear one of either two test or one control spectacle lens designs; the CPRO-1802-001 (Cypress_SG) study. The sponsor is interested in conducting choroidal thickness measurements only at CORE's site by inviting those participants who have already been found eligible for the CPRO-1802-001 study to participate in this parallel study.

Eligibility criteria: Inclusion Criteria:

* Participating in the CPRO-1802-001 (Cypress_SG) study at CORE
* Read and signed an Assent and their parent/guardian has signed an information consent letter

Exclusion Criteria:

* Transient health condition which may affect the eye(s) (e.g. a common cold, active allergies, fatigue, etc;)

Primary outcomes:
measure: Choroidal thickness
timeFrame: 3 years
Secondary outcomes:
measure: Visual field
timeFrame: 3 years
Other outcomes:
Locations:
city: Waterloo
country: Canada
facility: Centre for Ocular Research and Education
state: Ontario
Study officials:
affiliation: Centre for Ocular Research & Education, Canada
name: Lyndon Jones, PhD, FCOptom
role: PRINCIPAL_INVESTIGATOR
affiliation: Centre for Ocular Research & Education, Canada
name: Jill Woods, BSc, MCOptom
role: STUDY_DIRECTOR
References: