Clinical trial NCT06530901: Ultrasound of the Inferior Vena Cava in the Prevention of Hypotension After Induction of General Anesthesia
Official title: Multidimensional Ultrasound of the Inferior Vena Cava in the Prevention of Hypotension After Induction of General Anesthesia
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Elderly Patients Undergoing Elective Non-cardiac Surgery
Keywords: hypotension
general anesthesia
inferior vena cava
Lead sponsor: Yangzhou University
Sponsor class: OTHER
First posted: 2024-07-31
Enrollment: 100
Sex: ALL
Minimum age (years): 65
Maximum age (years): 85
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Elderly patients undergoing elective non-cardiac surgery under general anesthesia

Brief summary: Based on the preoperative ultrasound detection of various parametric indicators of the inferior vena cava cross-section, including the ratio of the inferior vena cava's long and short axes, cross-sectional area and circumference during two-dimensional and three-dimensional imaging, as well as the changes in respiratory variability of each parameter, we explored the predictive value of IVC ultrasound indicator parameters on hypotension after induction of general anesthesia in elderly patients undergoing elective non-cardiac surgery, screened the sensitive indicators, and calculated the cut-off values.


Eligibility criteria: Inclusion Criteria:

* Elderly patients undergoing elective non-cardiac surgery under general anesthesia;
* Age 65-85 years old;
* Body mass index (BMI) 18-28 kg/m2;
* American society of anesthesiologists (ASA) class I-III.

Exclusion Criteria:

* Patient refusal or lack of cooperation;
* Inability to communicate properly;
* Severe sinus bradycardia, pacemaker implantation, atrioventricular block, and atrial fibrillation;
* Presence of severe hepatic and renal function abnormalities;
* Preoperative cardiac ultrasound suggesting LVEF \<50%;
* Tricuspid valve displacement \<16 mm by preoperative cardiac ultrasound;
* Chronic obstructive pulmonary disease;
* Pulmonary hypertension;
* Administration of drugs that inhibit the renin-angiotensin-aldosterone system;
* Possibility of a difficult airway.

Primary outcomes:
measure: Changes in the level of Mean Arterial Pressure
timeFrame: Baseline (before induction), 10 min after induction
measure: Changes in the level of Systolic Blood Pressure
timeFrame: Baseline (before induction), 10 min after induction
measure: Multidimensional ultrasound of the inferior vena cava
timeFrame: Baseline (before induction)
Secondary outcomes:
measure: Changes in the level of Heart Rate
timeFrame: Baseline (before induction), 10 min after induction
measure: Changes in the level of Diastolic Blood Pressure
timeFrame: Baseline (before induction), 10 min after induction
Other outcomes:
Locations:
city: Yangzhou
country: China
facility: the Affiliated Hospital of Yangzhou University, Yangzhou University
state: Jiangsu
Study officials:
affiliation: The Affiliated Hospital of Yangzhou University
name: zhuan zhang, professor
role: PRINCIPAL_INVESTIGATOR
References: