Clinical trial NCT02368938: Prognosis in the Elderly Chinese: the Northern Shanghai Study
Official title: Prognosis Factors of Mortality and Cardiovascular Diseases in the Elderly Chinese: the Northern Shanghai Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cardiovascular Risk Factor
Keywords: Cardiovascular risk factors
Prospective study
Mortality
Cardiovascular events
Asymptomatic target organ damage
elderly Chinese
Lead sponsor: Shanghai 10th People's Hospital
Sponsor class: OTHER
First posted: 2015-02-23
Enrollment: 5000
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 5000 subjects aged over 65 years old, living in communities located in the northern Shanghai, will be invited to participate in the present study, if they are willing to give their written informed consents.

Brief summary: The Northern Shanghai Study is a prospective community-based study, which is aimed to investigate the prognostic factors, including conventional cardiovascular risk factors and asymptomatic target organ damage, for mortality and cardiovascular diseases, in 5,000 elderly Chinese.


Eligibility criteria: Inclusion Criteria:

1. age≥65 years old(depending on identity card);
2. informed consent should be signed voluntarily;
3. the individuals are long-term residents in northern Shanghai.

Exclusion Criteria:

1. is diagnosed serious heart disease (NYHA\>IV) or end stage renal disease (CKD \> 4);
2. suffered with cancer and life expectancy was less than 5 years;
3. has stroke within 3 months;
4. is not willing to participate in the clinical study;
5. suffered with other disease to quite the trial;
6. violated the protocol;
7. lost contact with laboratory staff.

Primary outcomes:
measure: all-cause and cardiovascular mortality, cardiovascular events
timeFrame: one year
measure: Cardiovascular diseases
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Lyu Y, Yu S, Chi C, Teliewubai J, Li J, Blacher J, Pu J, Zhang Y, Xu Y. Associations of Walking Activity With Hypertensive Mediated Organ Damage in Community-Dwelling Elderly Chinese: The Northern Shanghai Study. Front Cardiovasc Med. 2021 Oct 21;8:734766. doi: 10.3389/fcvm.2021.734766. eCollection 2021.
citation: Ren Z, Zhang J, Yu S, Zhao S, Tang J, Zheng Y, Meng W, Xu C, Zhang Y, Xu Y. Hypertension-Mediated Organ Damage Correlates With Serum Homocysteine Level in Community-Dwelling Elderly Chinese: The North Shanghai Study. Front Cardiovasc Med. 2021 May 10;8:662741. doi: 10.3389/fcvm.2021.662741. eCollection 2021.
citation: Xu C, Zhao S, Yu S, Chi C, Fan X, Ji H, Maimaitiaili R, Teliewubai J, Li X, Zhang Y, Xu Y. Association between organ damage and visceral adiposity index in community-dwelling elderly Chinese population: the Northern Shanghai Study. Aging Clin Exp Res. 2021 Aug;33(8):2291-2297. doi: 10.1007/s40520-020-01752-4. Epub 2020 Nov 21.
citation: Teliewubai J, Fan X, Ji H, Maimaitiaili R, Tang J, Zhao S, Yu S, Chi C, Xu Y, Zhang Y. Does healthy obesity exist in the elderly? Findings from the Northern Shanghai Study. Nutr Metab Cardiovasc Dis. 2020 May 7;30(5):749-757. doi: 10.1016/j.numecd.2020.01.010. Epub 2020 Jan 25.
citation: Fan X, Teliewubai J, Xiong J, Chi C, Lu Y, Zhu M, Zhang Y, Xu Y. Renal functional impairment in the elderly, the importance of fasting plasma glucose: the Northern Shanghai Study. Aging Clin Exp Res. 2021 Feb;33(2):353-360. doi: 10.1007/s40520-020-01527-x. Epub 2020 Mar 21.
citation: Chi C, Teliewubai J, Lu YY, Fan XM, Yu SK, Xiong J, Zhou YW, Ji HW, Zhang Y, Xu YW. Comparison of various lipid parameters in association of target organ damage: a cohort study. Lipids Health Dis. 2018 Aug 25;17(1):199. doi: 10.1186/s12944-018-0800-y.
citation: Teliewubai J, Bai B, Zhou Y, Lu Y, Yu S, Chi C, Li J, Blacher J, Xu Y, Zhang Y. Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study. Clin Interv Aging. 2018 Mar 6;13:389-395. doi: 10.2147/CIA.S155514. eCollection 2018.
citation: Xiong J, Yu X, Yu S, Bai B, Xu H, Ji H, Teliewubai J, Wang K, Chi C, Lu Y, Zhou Y, Fan X, Li J, Zhang Y, Xu Y. Comparison of central and peripheral hemodynamics in association with left ventricular diastolic dysfunction in the community-based elderly Chinese. J Am Soc Hypertens. 2017 Jun;11(6):366-375. doi: 10.1016/j.jash.2017.04.009. Epub 2017 Apr 27.
citation: Ji H, Xiong J, Yu S, Chi C, Fan X, Bai B, Zhou Y, Teliewubai J, Lu Y, Xu H, Zhang Y, Xu Y. Northern Shanghai Study: cardiovascular risk and its associated factors in the Chinese elderly-a study protocol of a prospective study design. BMJ Open. 2017 Mar 29;7(3):e013880. doi: 10.1136/bmjopen-2016-013880.
citation: Lu Y, Zhu M, Bai B, Chi C, Yu S, Teliewubai J, Xu H, Wang K, Xiong J, Zhou Y, Ji H, Fan X, Yu X, Li J, Blacher J, Zhang Y, Xu Y. Comparison of Carotid-Femoral and Brachial-Ankle Pulse-Wave Velocity in Association With Target Organ Damage in the Community-Dwelling Elderly Chinese: The Northern Shanghai Study. J Am Heart Assoc. 2017 Feb 20;6(2):e004168. doi: 10.1161/JAHA.116.004168.