Clinical trial NCT02051127: The Effects of Physical Training on Physiological and Psychological Stress-reactions and Cognitive Function.
Official title: Sustainable Working Life With Reduced Stress Levels - The Effects of Physical Training on Physiological and Psychological Stress-reactions and Cognitive Function.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Volunteers
Sedentary Lifestyle
Keywords: Exercise
Physical Fitness
Stress, Psychological
Cognition
Psychophysiology
Ergometry
Exercise Test
Sedentary Lifestyle
Lead sponsor: Vastra Gotaland Region
Sponsor class: OTHER_GOV
First posted: 2014-01-31
Enrollment: 119
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: One of the biggest challenges of today is the high stress levels among employees in companies and organizations. Physical exercise may be an effective preventive measure for stress-related problems. This relatively simple and inexpensive action is believed to be important for increasing and maintaining work ability and reduce the cost of stress-related ill health in the workplace.

The aim is to investigate how regular physical exercise affects the individual's ability to mentally and physiologically cope with stress. Acute stress physiological responses are measured before and after a 6 -month intervention, where 100 untrained individuals are randomized to either regular physical exercise or a control group.

The hypothesis is that exercise leads to lesser activation of the individual's stress physiological systems and to an efficient physiological protection system. Mental ability to handle stress is also studied as well as possible effects on the brain's cognitive functions. From a work perspective, cognitive impairment due to high exposure to stress is a major problem leading to substantial costs in businesses and organizations as a result of reduced performance and production.

We believe that physical activity can alter and mitigate individual stress reactions. This study brings new knowledge that can contribute to increased motivation to prioritize physical activity in everyday life. The study could also provide evidence for businesses and organizations of the benefits of engaging in interventions and fitness initiatives to facilitate/enable increased physical activity in daily life for its employees. With an aging population, we are expected to work longer, which poses a challenge as the ability to manage stress and maintain cognitive abilities decline with age. For older employees, regular physical activity could be an important factor directly affecting the prospects for a sustainable working life.


Eligibility criteria: Inclusion Criteria:

* Self-reported good health
* Sedentary
* Work or study at least 50%

Exclusion Criteria:

* Diabetes
* Cardiovascular disease
* Blood pressure \> 140/90
* Psychiatric disease
* Anemia
* Medication with substances that could affect any of the outcome measures

Primary outcomes:
measure: Cortisol responses to acute psychosocial stress.
timeFrame: 6 months after start of intervention
Secondary outcomes:
measure: Cognitive function
timeFrame: 6 months after start of intervention
measure: Self-reported stress sensitivity and symptoms
timeFrame: 6 and 12 months after start of intervention
measure: Adrenocorticotropic hormone (ACTH) response to psychosocial stress
timeFrame: 6 months after start of intervention
measure: Dehydroepiandrostreone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) response to psychosocial stress
timeFrame: 6 months after start of the intervention
Other outcomes:
measure: Autonomic responses to acute psychosocial stress
timeFrame: 6 months after start of intervention
measure: Neuroendocrine and autonomic responses to exercise test
timeFrame: 6 months after start of intervention
Locations:
city: Gothenburg
country: Sweden
facility: The Institute of Stress Medicine
state: VGR
Study officials:
affiliation: Västra Götalandsregionen
name: Ingibjörg H Jonsdottir, Professor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Arvidson E, Dahlman AS, Borjesson M, Gullstrand L, Jonsdottir IH. The effects of exercise training on hypothalamic-pituitary-adrenal axis reactivity and autonomic response to acute stress-a randomized controlled study. Trials. 2020 Oct 27;21(1):888. doi: 10.1186/s13063-020-04803-3.