Clinical trial NCT04201691: Effect of Manuel Therapy on Tonus, Proprioseption and Balance in Multiple Sclerosis
Official title: The Effect of Cervical Mobilization on Tonus, Position Sense and Balance in Multiple Sclerosis Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postural Balance
Multiple Sclerosis
Cervical Region Disorder Nos
Muscle Tonus
Proprioception
Lead sponsor: Hasan Kalyoncu University
Sponsor class: OTHER
First posted: 2019-12-17
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Participants are grouped randomly. First group and second group are applied different rehabilitation programs. Both of group is rest four weeks. Than second group is applied first group's rehabilitation program and first group is applied second group's rehabilitation program.
Primary purpose: TREATMENT

Brief summary: This study is investigates the effect of cervical mobilization on tonus, position sense and balance in patient with multiple sclerosis. Half of participants will received classic rehabilitation program, while the other half will received servical mobilization in addition to classic rehabilitation program.

Detailed description: Cervical region is rich in terms of muscle spindle and reseptors. When this region is touched by physiotherapists, muscle spindles is activited. Thus position sense of joint and balance is developed. Besides, cervical region is parasympathetic area have common relaxed effect. Thus this part can be benefit to regulation of tonus.

Eligibility criteria: Inclusion Criteria:

* Expanded Disability Status Scale (EDSS) score was between 2-5,
* According to the modified Ashworth Scale, spasticity is between 1 and 3,
* EDSS Cerebellar System Sub-Scale, Functional System Score ˃1,
* medical condition is stable and no medication changes were made in the last month,
* Vertebro-basillar test negative,
* Not have any other neurological disorder and orthopedic problem to prevent participation in this study
* A score of at least 24 from the Mini Mental Test,

Exclusion Criteria:

* presence of psychiatric or severe cognitive dysfunction,
* pregnancy,
* Having a neurological disease other than MS,
* having had an attack in the last 3 months,
* Botulinum toxin application within the last 6 months,
* participating in physiotherapy program in the last 6 months

Primary outcomes:
measure: Change Modified ashworth scale
timeFrame: Change from Modified ashworth scale at one month
measure: Change Berg Balance Test
timeFrame: Change from Berg Balance Test at one month
measure: Change Dynamic Gait Index
timeFrame: Change from Dynamic Gait Index at one month
measure: MyotonPRO
timeFrame: 30 days
measure: Change The timed 25-foot walk
timeFrame: Change from The timed 25-foot walk at one month
measure: Change Functional Reach Test
timeFrame: Change from Functional Reach Test at one month
measure: Change Sharpened Romberg
timeFrame: Change from Sharpened Romberg at one month
measure: Change Single Leg Stance Test- Right
timeFrame: Change from Single Leg Stance Test- Right at one month
measure: Change Single Leg Stance Test- Left
timeFrame: Change from Single Leg Stance Test- Left at one month
measure: Change Joint of position sense
timeFrame: Change from Joint of position sense at one month
Secondary outcomes:
Other outcomes:
Locations:
city: Gaziantep
country: Turkey
facility: Hasan Kalyoncu University
Study officials:
References: