louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01890057: The Dose of Sugammadex for Rapid Reversal of Profound Neuromuscular Block in Young and Elderly Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anesthesia Recovery Period, Neuromuscular Blockade
Lead sponsor: Severance Hospital
Sponsor class: OTHER
First posted: 2013-07-01
Enrollment: 44
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL

Brief summary: To find out the dose of sugammadex for recovery of the TOF ratio to 0.9 within 2 minutes from profound rocuronium-induced neuromuscular block in young and elderly adult patients.

Detailed description: A previous study reported that elderly patients required a longer time to recover from rocuronium induced neuromuscular block compared to younger patients. Therefore, the aim of this study is to find out the dose of sugammadex for rapid recovery from profound neuromuscular block in young and elderly adult patients.

Eligibility criteria: Inclusion Criteria:

* 20-40 years or ≥70 years ASA class I-II patients who received surgery less than 2 hours.

Exclusion Criteria:

* anticipated difficult intubation
* neuromuscular, hepatic or renal disorders
* drug allergy
* body mass index \>30 kg/m2 or body mass index \<18 kg/m2
* emergency surgery

Primary outcomes:
measure: The dose of sugammadex for recovery of the TOF ratio to 0.9 within 2 minutes from profound neuromuscular block
timeFrame: 2 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine
Study officials:
References:
Clinical trial NCT01809457: Effectiveness of Dental Trauma Educational Poster to Secondary Students
Official title: Effectiveness of Educational Poster to Secondary Students Regarding Knowledge of Emergency Management of Dental Trauma - A Cluster Randomised Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Injuries
Keywords: educational poster, knowledge, dental trauma,
Lead sponsor: The University of Hong Kong
Sponsor class: OTHER
First posted: 2013-03-12
Enrollment: 671
Sex: ALL
Minimum age (years): 11
Maximum age (years): 20
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: to investigate the effectiveness of the educational poster regarding knowledge of dental trauma for the secondary school students

Detailed description: To investigate the effectiveness of the educational poster about dental trauma to increase the knowledge of secondary students.

Schools will be randomly divided into two groups, baseline score of knowledge in questionnaire will be collected for all subjects. Poster will be sent to intervention group, the school will place it at the notice broad or area of similar function in the classroom. For the control group, nothing will be given, then after 2 weeks, the score of knowledge by the second questionnaire of both groups will be collected again.

To compare the difference in knowledge before and after in both groups, statistical test will be performed.

Investigators conduct a cluster randomized controlled trial. A list of secondary schools was requested from the Education Bureau. Secondary schools will be invited to join the study and then randomized to the intervention group and the control group in the unit of school using computer generated numbers. All students will fill in the first questionnaire and send it back to the investigator in 1 week. Then copies of the same poster will be given to the intervention schools, these schools will be requested to place them in the classrooms of the participating students. No poster will be given to the control group. After 2 weeks, the poster will be removed. The same questionnaire will be filled out by all the students in both groups and sent back in 1 week. Then the data will be processed to show whether the poster is effective to improve the knowledge of the students.

Eligibility criteria: Inclusion Criteria

- All secondary schools in Hong Kong that the students can read Chinese or English

Exclusion Criteria

- no school consent or individual guardian consent

Primary outcomes:
measure: knowledge score
timeFrame: 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: secondary schools in Hong Kong
Study officials:
affiliation: Independent
name: Cecilia Young, BDS, MPH
role: PRINCIPAL_INVESTIGATOR
References:
citation: Young C, Wong KY, Cheung LK. Effectiveness of educational poster on knowledge of emergency management of dental trauma--part 2: cluster randomised controlled trial for secondary school students. PLoS One. 2014 Aug 5;9(8):e101972. doi: 10.1371/journal.pone.0101972. eCollection 2014.
Clinical trial NCT04067557: Diagnosis of Bacterial Vaginosis Comparing Modified Hay/Ison With Molecular Diagnosis
Official title: Diagnosis of Bacterial Vaginosis Using Molecular PCR Test.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Infection, Bacterial
Lead sponsor: Skaraborg Hospital
Sponsor class: OTHER_GOV
First posted: 2019-08-26
Enrollment: 300
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: women that are scheduled a therapeutic abortion screening visiting Skaraborg hospital Sweden

Brief summary: Among 300 women that are scheduled a therapeutic abortion screening diagnopsis of BV are done using Gram stained vaginal smear and with a molecular test using PCR for 5 different bacteria.

Detailed description: The molecular test will test for Atophobium vaginae, Leopitrichia spp, Megasphaera Mobiluncus and BVAB2

Eligibility criteria: Inclusion Criteria:

women scheduled a therapeutic abortion (Before 12th week) will be screened for gential infections such as chlamydia and Gc together with bacterial vaginosis

Exclusion Criteria:

* women not pregnat

Primary outcomes:
measure: Diagnosis of bacterial vaginosis comparing modified Hay/Ison with molecular diagnosis
timeFrame: 4 month
Secondary outcomes:
Other outcomes:
Locations:
city: Skövde
country: Sweden
facility: Department of Ob/Gyn, Skaraborgshospital Skövde
Study officials:
affiliation: professor
name: P-G Larsson
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00616057: Evaluation of Fructans Supplementation on Parameters of Metabolic Syndrome
Official title: Evaluation of Fructans Supplementation on Parameters of Metabolic Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Keywords: fructans supplementation
Lead sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sponsor class: OTHER
First posted: 2008-02-15
Enrollment: 34
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Obesity is constantly increasing, causing an important risk to develop diseases such as heart disease, diabetes,... Some recent studies have shown that obese people present modifications of colon microflora and a low-grade inflammation.

In our laboratory, we have demonstrated that the intake of fructans lessens dietary intake, body weight gain, adipose tissue accumulation and steatosis in rodents. These effects lead to an improvement of insulin resistance and hyperglycemia in diabetic rats and mice. Fructans are also able to restore the microflora disturbed by a high fat diet and to prevent endotoxemia. Moreover, studies have shown that fructans intake promotes satiety (Cani et al, Diabetes 2007) and or decreases fat mass (Abrams et al, Journal of Pediatrics 2007) in healthy human. An intervention study in obese patients is thus needed to study the effects of fructans in the target population.


Eligibility criteria: Inclusion Criteria:

* BMI\>30 kg/m2

Exclusion Criteria:

* acute or chronic evoluting disease
* alcohol consumption \> 30 units/week
* more than 30 minutes of sports 3 times/week
* usual consumption of pre/probiotics or fibers supplement
* recent consumption of antibiotics
* slimming diet or unusual diet
* pregnant women
* anti-diabetics drugs ou slimming drugs
* previous bariatric surgery
* severe oesophagus reflux

Primary outcomes:
measure: gut microbiota composition
timeFrame: 3 months
Secondary outcomes:
measure: gut microbial-related metabolites (in urine and plasma)
timeFrame: 3 months
measure: metabolic parameters (weight, BMI, glycemia, fat mass,...)
timeFrame: 3 months
Other outcomes:
Locations:
city: Bruxelles
country: Belgium
facility: Cliniques universitaires Saint Luc
state: Branbant Wallon
Study officials:
affiliation: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
name: Thissen Jean-Paul
role: PRINCIPAL_INVESTIGATOR
References:
citation: Salazar N, Dewulf EM, Neyrinck AM, Bindels LB, Cani PD, Mahillon J, de Vos WM, Thissen JP, Gueimonde M, de Los Reyes-Gavilan CG, Delzenne NM. Inulin-type fructans modulate intestinal Bifidobacterium species populations and decrease fecal short-chain fatty acids in obese women. Clin Nutr. 2015 Jun;34(3):501-7. doi: 10.1016/j.clnu.2014.06.001. Epub 2014 Jun 11.
Clinical trial NCT02560857: Clinical Evaluation of Quantiferon-Monitor to Predict Outcomes in Solid Organ Transplant Recipients
Official title: Clinical Evaluation of Quantiferon-Monitor to Predict Outcomes in Solid Organ Transplant Recipients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Immunity, Cellular
Keywords: Quantiferon-Monitor
organ rejection
global immunity
Lead sponsor: University Health Network, Toronto
Sponsor class: OTHER
First posted: 2015-09-25
Enrollment: 151
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adult SOT recipients on at least one immunosuppressive medication.

Brief summary: The study will prospectively determine the clinical utility of non-pathogen specific cellular immunity assessment using the Quantiferon-Monitor to quantify the degree of immunosuppression. The investigators will use the results of the assay to predict whether patients develop opportunistic infections and predict organ rejection.

Detailed description: Solid organ transplant (SOT) recipients undergo life-long immunosuppression to prevent allograft rejection. However, this also puts patients at significant risk for opportunistic infection. The degree of immunosuppression varies for each individual and is likely influenced by a combination of clinical factors such as antirejection medication, comorbidities, patient age as well as the state of patient immune system. Thus far, there have been no standardized methods to quantify the degree of global immunosuppression. A new blood test (Quantiferon-Monitor) has been recently developed that might help predict the level of immune suppression. The purpose of this study is to determine whether this new test will help determine a person's level of immune suppression after organ transplant. This will be done by trying to relate the level of immunity with the development of infection or rejection. If the test for immunosuppression is helpful, it may help us to better take into account the differences in patients when designing therapy. Ultimately, it may help develop better ways for preventing infections and transplant rejections.

Eligibility criteria: Inclusion Criteria:

* Adult SOT recipients on at least one immunosuppressive medication able to comply with the protocol.

Exclusion Criteria:

* None

Primary outcomes:
measure: Number of participants that develop Opportunistic infections
timeFrame: 1 year
Secondary outcomes:
measure: Number of participants that develop Acute cellular rejection
timeFrame: 1 year
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: University Health Network, Toronto General Hospital, Multi-Organ Transplant
state: Ontario
Study officials:
References:
Clinical trial NCT03095157: The Emerging Role of Resolvins in the Prevention of Chronic Pain After Thoracic Surgery
Official title: The Emerging Role of Resolvins in the Prevention of Chronic Pain After Thoracic Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Patients Scheduled for Thoracic Surgery/Esophagectomy Will be Enrolled
Persistent Post Surgical Pain
Lead sponsor: Brigham and Women's Hospital
Sponsor class: OTHER
First posted: 2017-03-29
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of the study is to investigate whether pre-operative dysregulated systemic lipid mediator pathways are associated with increased risk for the development of persistent post surgical pain. In addition we will investigate whether treatment with an over the counter dietary supplement containing a fractionated marine lipid derivative from anchovy and sardine oil prevents the development of chronic pain after surgery.


Eligibility criteria: Inclusion Criteria:

* scheduled to undergo esophagectomy at BWH
* 18-80 years old

Exclusion Criteria:

* pre-existing chronic pain
* current opioid use
* current treatment with corticosteroids
* evidence of active infection
* chronic liver disease
* end-stage renal disease (CKD-5)
* chronic inflammatory disorders
* recent major surgery or illness within 30 days
* use of immunosuppressive medication
* history of organ transplant
* pregnancy or plans to become pregnant
* lactating
* allergies to fish or fish oil

Primary outcomes:
measure: Numeric Rating Scale (0=no pain; 10=worst imaginable pain) at 3 months after surgery
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06876857: University of Central Florida CereBank
Official title: University of Central Florida CereBank
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Biospecimen Donation
Brain Injury
Brain Diseases
Keywords: donate
biobank
brain
biospecimen
Alzheimer's Disease
Autism
Huntington's Disease
Lead sponsor: University of Central Florida
Sponsor class: OTHER
First posted: 2025-03-14
Enrollment: 50000
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants will donate brain tissue for research and education, aimed at improving the diagnosis and treatment of brain diseases.

Brief summary: Millions of persons are affected by brain diseases. The CereBank will be used to support research studies aimed at improving the diagnosis and treatment of brain diseases. Brain diseases can be inherited; developed due to diseases or aging; or can be due to trauma. The Central Florida does not have a brain biobank to meet the needs of research. Therefore, it is necessary for the University of Central Florida to establish a brain biobank.

Detailed description: The purpose of the University of Central CereBank is to be a brain repository to support the research of the faculty of the University of Central Florida College of Medicine. These research studies aim at improving the diagnosis and treatment of brain diseases, such as dementia, to advance medicine. The donated brains will be used for research and educational purposes.

Eligibility criteria: Inclusion Criteria:

* Be 18 years or older.
* Able to provide informed consent. Persons who are unable to provide an informed consent will need a Legally Authorized Representative (LAR) to sign the informed consent.

Exclusion Criteria:

* minors (under age 18).
* prisoners.
* pregnant women.

Primary outcomes:
measure: Receipt of donated brain tissue and biospecimens for research and educational purposes
timeFrame: 75 years
Secondary outcomes:
Other outcomes:
Locations:
city: Orlando
country: United States
facility: University of Central Florida
state: Florida
Study officials:
References:
Clinical trial NCT03464357: Functional MRI Study of Cortical Modifications to Light Stimulation in Patients With Photophobia
Official title: Modification of Cortical Activation After Luminous Stimulation in Functional Magnetic Resonance Imaging (MRI) in Patients With Photophobia Related to Moderate to Acute Dry Eye Syndrome.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Dry Eye Syndrome
Photophobia
Keywords: functional MRI
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
First posted: 2018-03-14
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: The study will compare the extent of neuronal activation at the visual cerebral cortex between a group with photophobia related to dry eye syndrome and a group of asymptomatic patients (without dry eye and no photophobia) with an MRIf.
Primary purpose: OTHER

Brief summary: Photophobia is a common and disabling symptom in patient with dry eye syndrome. The aim of this study is tried to better understand this complain analyzing brain activation during a luminous stimulation to highlight modification of cortical activation.

Detailed description: Dry eye syndrome is a frequent and underestimated disease whose incidence tends to increase because of the population ageing and behaviors modification (time spent using screens increased, wearing of contact lenses...). Photophobia deteriorates the quality of life in patients with dry eye syndrome decreasing outdoor activities. This symptom is not understood and does not seem to be linked with dry eye syndrome severity. The study will compare cortical activation after luminous stimulation of 16 patients eyes (8 patients with dry eye syndrome and photophobia vs 8 asymptomatic patients) using functional MRI (fMRI).

The primary study endpoint was the extent of magnetic signals in visual cortex after luminous stimulation. Secondary endpoints were the spatial activation extent in the 3 areas of the visual cortex (Brodmann areas 17,18,19).

Eligibility criteria: Inclusion Criteria:

* Symptomatic subjects : presence of bilateral photophobia with an impact on daily activities (driving, outdoor activities, screens use, socio-professional activities...) in a context of patent dry eye syndrome
* Asymptomatic subjects : no dry eye syndrome and no photophobia
* Patients able to understand medical information and sign consent.

Exclusion Criteria:

* Ophthalmological pathologies of cornea, iris, optic nerve or retina
* MRI contraindications (metallic prosthesis, pacemaker, claustrophobia)
* Neurological pathology which may affect MRI results
* Subjects under legal protection

Primary outcomes:
measure: The spatial extent of activation of the visual cortex
timeFrame: One day
Secondary outcomes:
Other outcomes:
Locations:
city: Toulouse
country: France
facility: University Hospital Toulouse
Study officials:
affiliation: University Hospital, Toulouse
name: François Malecaze, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04488848: Cardiometabolic Effects of Rapid Glucose Excursion
Official title: Effect of Rapid Glucose Excursion Versus Continuous Glucose Infusion on Cardiovascular and Metabolic Parameters in Healthy Volunteers
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Diabetes Mellitus, Experimental
Lead sponsor: Barmherzige Brüder Linz
Sponsor class: OTHER
First posted: 2020-07-28
Enrollment: 10
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The effects of rapid glucose excursions, induced by intravenous bolus application of glucose in healthy probands, on cardiometabolic and inflammatory parameters will be investigated

Detailed description: BACKGROUND: It is well known that people with diabetes have a five times higher risk of dying of cardiovascular death than non-diabetics. However not only hyperglycaemia per se but also glycaemic variability is currently particularly regarded as a risk factor for cardiovascular and microvascular complications. Intermittent blood sugar excursions with pronounced fluctuations between high and low values instead of constant, even increased blood sugar exposure, have been shown to be more harmful in several studies.

AIM: The aim of this study is to determine the effect of rapid glucose excursion versus continuous glucose infusion on cardiovascular and metabolic parameters in healthy volunteers.

METHODS/DESIGN: In this study, ten healthy male subjects will be studied on two occasions. In a random order the subjects will receive 3 times 20 grams of glucose intravenously as a bolus or, on the other occasion, 60 grams of glucose continuously over 3 hours. Cardiometabolic biomarkers will be analysed serially to analyse the effects of glucose excursions.

PROSPECT: Glycaemic variability may be a crucial factor in the development of diabetic complications, but there is currently a lack of conclusive evidence. The causes and mechanisms of these negative influences on the cardiovascular system due to high glucose variability have not been sufficiently investigated and are therefore not fully understood so far. To date, however, there have been no studies with acutely altered glucose concentrations in healthy volunteers that have investigated the effects on traditional as well as recently identified cardiovascular and metabolic biomarkers. Knowledge of such effects may improve the therapeutic strategy in diabetic patients.

Eligibility criteria: Inclusion Criteria:

* Men aged 18 years or older with no disease history
* written informed consent

Exclusion Criteria:

* receiving any medication
* probands who suffer from infectious disease

Primary outcomes:
measure: Interleukin-6
timeFrame: 48 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Linz
country: Austria
facility: Barmherzige Brüder Linz - Innere Medizin
Study officials:
References:
Clinical trial NCT02216448: Arthroscopy Simulator Training vs OR Training Knee
Official title: The Benefit of Arthroscopic Simulator Training Versus Operating Room Training in Diagnostic Knee Arthroscopy for Residents With Basic Arthroscopic Skills
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Knee Arthroscopy Skills
Keywords: Arthroscopy skills
Knee
Virtual reality
Simulator
Lead sponsor: Sheba Medical Center
Sponsor class: OTHER_GOV
First posted: 2014-08-15
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The purpose of this study is to compare between two groups of residents with basic arthroscopic skills in diagnostic knee arthroscopy. The first group will train on a knee arthroscopic simulator in a lab, and the second group will perform diagnostic knee arthroscopy in the operating room. Both groups will be assessed by senior arthroscopy surgeon in the operating room based on selected competencies following the Global Rating System.


Eligibility criteria: Inclusion Criteria:

* Orthopedic residents

Exclusion Criteria:

* none

Primary outcomes:
measure: Global rating scale
timeFrame: completion of training
Secondary outcomes:
measure: simulator parameters
timeFrame: Completion of training
Other outcomes:
Locations:
city: Ramat Gan
country: Israel
facility: Sheba Tel Hashomer
Study officials:
References: