Clinical trial NCT05809076: Effects of Gamma-tACS on EEG Periodic Activity
Official title: Evaluation of the Effects of Gamma-tACS on the Periodic Activity of Neural Signals as a Function of State-dependency
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Transcranial Alternating Current Stimulation
Lead sponsor: IRCCS San Camillo, Venezia, Italy
Sponsor class: OTHER
First posted: 2023-04-12
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: In this study on healthy subjects, the effect of transcranial alternating current stimulation (tACS) will be investigated. In particular, the distinction between periodic and aperiodic electroencephalogram (EEG) activity will be considered, as well as the state-dependency phenomenon. Participants will take part in two experimental sessions that will include tACS stimulation (one real, one control). Before, during, and after stimulation, subjects will have their EEG recorded during rest or during tasks.

The aim of this study is to investigate how the modulatory effects of gamma-tACS interact with intrinsic neural activity, measured in terms of periodic and aperiodic activity, as well as neurophysiological and behavioral modulation, taking into consideration the state-dependency phenomenon, which refers to the brain's activation state prior to stimulation.


Eligibility criteria: Inclusion Criteria:

- Healthy adults

Exclusion Criteria:

* Common exclusion criteria
* Left-handedness (assessed through the Oldfield test)
* Diagnosis of neurological or psychiatric disorders
* Vision problems that prevent reading, not correctable with lenses
* Diagnosis of substance dependence on drugs or alcohol
* Presence of hearing aids/prostheses
* Diagnosis of epilepsy or family history up to the second degree with it
* Episodes of febrile convulsions or recurrent fainting
* Head trauma
* Presence of surgical clips or metal implants in the head
* Diagnosis of heart disease
* Presence of a cardiac pacemaker or artificial heart valve
* Presence of hearing aids/prostheses
* Hearing problems or tinnitus
* Vision problems not corrected with lenses (such as color blindness)
* Taking tricyclic antidepressant medications
* Taking neuroleptic medications
* Diagnosis of headache or migraine
* Taking more than 3 alcoholic units in the last 24 hours
* Taking 2 or more cups of coffee or caffeine from other sources in the last 2 hours

Primary outcomes:
measure: resting-state electroencephalography (EEG) signal
timeFrame: baseline
measure: resting-state electroencephalography (EEG) signal
timeFrame: during the intervension
measure: resting-state electroencephalography (EEG) signal
timeFrame: immediately after the intervention
Secondary outcomes:
measure: behavioral performance (response times)
timeFrame: baseline
measure: behavioral performance (response times)
timeFrame: immediately after the intervention
measure: behavioral performance (accuracy)
timeFrame: baseline
measure: behavioral performance (accuracy)
timeFrame: immediately after the intervention
measure: auditory steady state response (ASSR)
timeFrame: baseline
measure: auditory steady state response (ASSR)
timeFrame: immediately after the intervention
Other outcomes:
Locations:
city: Venice
country: Italy
facility: IRCCS San Camillo Hospital
Study officials:
affiliation: IRCCS San Camillo Hospital
name: Arcara
role: PRINCIPAL_INVESTIGATOR
References: