Clinical trial NCT04820062: Antibiotic Prescribing Behavior Among French Intensivist: Construction and Validation of a Questionnaire
Official title: Antibiotic Prescribing Behavior Among French Intensivist: Construction and Validation of a Questionnaire
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Antibiotic Reaction
Keywords: Antibiotic prescribing
questionnaire
Antibiotic resistance
behavior
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2021-03-29
Enrollment: 115
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Physicians with predominant intensive care practice and Resident, with a minimum of two-month experience in the intensive care unit can be participe at this study.

Brief summary: Antibiotic resistance is a major threat in modern medicine. Overuse of antibiotics is an important driver of antibiotic resistance. However, some authors have shown that up to 50% of antibiotic treatments in critically ill patients are inappropriate, mostly because they are used in patients with non-bacterial infections.

In order to improve antibiotic use, several antibiotic stewardship programs have been implemented worldwide. However, only few of them have taken into account the determinants of prescribing behaviors. Yet, these determinants have been shown to play a role among general practitioners of hospital doctors. Nevertheless, none of these factors have been studied among intensivists.

The current project represent phase 1 of the study : construction and validation of a questionnaire.

Detailed description: Antibiotic resistance is a major threat in modern medicine. Overuse of antibiotics is an important driver of antibiotic resistance. In critical care setting, antibiotic therapies are widely used due to the high number of patients presenting with sepsis. However, some authors have shown that up to 50% of antibiotic treatments in critically ill patients are inappropriate, mostly because they are used in patients with non-bacterial infections.

In order to improve antibiotic use, several antibiotic stewardship programs have been implemented worldwide. However, only few of them have taken into account the determinants of prescribing behaviors. Yet, these determinants have been shown to play a role among general practitioners of hospital doctors. Nevertheless, none of these factors have been studied among intensivists.

The study is designed to investigate social, cultural, contextual and personal factors influencing antibiotic prescribing among French intensivists. The design will consist of three phases:

* Phase 1: construction and validation of a questionnaire
* Phase 2: the questionnaire will be sent to all intensivist, including residents, in France
* Phase 3: qualitative study, based on semi-structured interviews.

The current project represent phase 1 of the study.

Eligibility criteria: Inclusion Criteria:

* Physicians with predominant intensive care practice
* Resident, with a minimum of two-month experience in the intensive care unit

Exclusion Criteria:

* Refusal to participate

Primary outcomes:
measure: Content validity
timeFrame: months 18
Secondary outcomes:
measure: Face validity
timeFrame: months 18
Other outcomes:
measure: Construct validity
timeFrame: months 18
Locations:
city: Saint-Étienne
country: France
facility: Chu St Etienne
Study officials:
affiliation: CHU ST ETIENNE FRANCE
name: Guillaume THIERY, MD PHD
role: PRINCIPAL_INVESTIGATOR
References: