lokahq/bioreason-rl huggingface dataset:
Protein: Proton-activated chloride channel (PAC) (fPAC) (Transmembrane protein 206) (Q7SY31)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH. Displays channel activity with distinct kinetic properties compared to the human ortholog channel.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9H813}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H813}.
InterPro domains:
- IPR029366: TMEM206 protein (family) [2-298]
Sequence:
MPIGFNKACLKNVFTVILVLIYLALTAVAVFLAYQTISDFMDKLNHPVMSVSYKEVEEFAAPGIVLFPGKAHLLSCMHHYHDNIPPLVALENLAKRECMKEEVIYHGPYSNQTEKRALVFRGPTDVRNRELIFLQLSRNETEEDFSAISYMIFAKFSDMLESSDKAAFMMDCERNYSMWTFSGGFRTWVKMSLVRTSGRRNESVEFRQESSVVKYIDKRPPLEQTNELFFIVFQWRDPFIQQVKDIVTANPWNTIAILCGVFMALFKAADFAKLSIKWMIRIRKRHIRAKMREMNQIS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015108 (chloride transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0015267 (channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0005253 (monoatomic anion channel activity), GO:0022836 (gated channel activity), GO:0005254 (chloride channel activity), GO:0061797 (pH-gated chloride channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0006821 (chloride transport), GO:0006820 (monoatomic anion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Transcription factor Sp2 (Q02086)
Organism: Homo sapiens (Human)
Function: Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
Subcellular location: Nucleus.
InterPro domains:
- IPR013087: Zinc finger C2H2-type (domain) [525-612]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [505-608]
Sequence:
MSDPQTSMAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPGKNSFGILSSKGNILQIQGSQLSASYPGGQLVFAIQNPTMINKGTRSNANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIPGTNQAIITPSPSSHKPVPIKPAPIQKSSTTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNASDTGAPTQLLTESPPTPLSKTNKKARKKSLPASQPPVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPTPTQVYIRTPSGEVQTVLVQDSPPATAAATSNTTCSSPASRAPHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLVTKNL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0035264 (multicellular organism growth), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0008283 (cell population proliferation), GO:0009790 (embryo development), GO:0048731 (system development), GO:0048144 (fibroblast proliferation), GO:0048513 (animal organ development), GO:0048568 (embryonic organ development), GO:0072359 (circulatory system development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0001701 (in utero embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Intermediate filament protein A (IF-A) (P23730)
Organism: Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Function: Not known
Subcellular location: Cytoplasm.
InterPro domains:
- IPR039008: Intermediate filament, rod domain (domain) [1-342]
- IPR016451: Intermediate filament, ifa/ifb (family) [1-496]
- IPR001322: Lamin tail domain (domain) [375-493]
- IPR018039: Intermediate filament protein, conserved site (conserved_site) [328-336]
- IPR036415: Lamin tail domain superfamily (homologous_superfamily) [351-496]
Sequence:
MSDLNDRLASYIEKVRFLEAQNRKLAADLDLLRGRWGKDTLSVRAMYEGELQEARKLVNDTNRQREELEKEIRKLLDELSEYRRKYEDALRGHQIDRDRIDELLNQLSGLEAEINLLRRRIANIIEEIARIKKENLQFANELTKARSDLDQETLNRIDFQNQVQTLLEEIDFMRRVHDQEIAELQAMASRDTTPENREYFKNELASAIRDIRAEYDQICNVNRMDMESWYKLKVQEIQTQSTRQNLEQNYAKKRLRVQLTDLRGKLADLEGRNSLLKQTQELNYQLEDDQRSYEAALNDRDAQIRKMDEECQALMMLLDTKQTLDAEIAIYRKMLEGEENRAGLRQLVEQVVKTHGLTQVDETESLRVLKGETASRTSFQRSAKGNVSIQETAPDGRYVVLENTHRSKEEAIGEWKLKRKIDGKREIVYTLPRDFILRPGKSVKIWARGQGGIHSPPEQLVFDLEDTFGSGSNVQTILFNREGEERATHIQRSSHTI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0098609 (cell-cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005882 (intermediate filament), GO:0045111 (intermediate filament cytoskeleton)
Protein: ATP-dependent RNA helicase (EC 3.6.4.13) (C6KTE4)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
InterPro domains:
- IPR044773: DDX18/Has1, DEAD-box helicase domain (domain) [160-354]
- IPR000629: ATP-dependent RNA helicase DEAD-box, conserved site (conserved_site) [300-308]
- IPR014014: RNA helicase, DEAD-box type, Q motif (domain) [148-176]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [76-595]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [167-369]
- IPR011545: DEAD/DEAH-box helicase domain (domain) [172-341]
- IPR001650: Helicase, C-terminal domain-like (domain) [365-525]
- IPR025313: ATP-dependent rRNA helicase SPB4-like, C-terminal extension (domain) [526-589]
Sequence:
MMDDDNDYNTMKNSNDNNLKKTKKNSIIKKKKKKKKKEILENKDSNIDNLKNENYRSESEAESESTNDSVSLNNIEEDNELNENSENNENNENDEDNKNNKNNENNENTSSEEICDHDKNDKTYTDEIKSNNSDHNNNNSKEHFYSELKFEELNICDALKKGLKELNFVTLTEIQAKCIPHFLSGKDILGAAKTGSGKTLAFLVPSINILYNIKFLPKNGTGVLIISPTRELCLQIYQVCKDLCKYIPQTNGIIIGGMSRNEEKKKFIHGINILIATPGRLLDHMQNTKEFIYKNLICLIIDEADRLLQIGFEEEINLIIKRLPKKRQTALFSATQTTKVESLIRLSLQKPIFIEVTTKIATVERLQQGYALVDEDKRFLLLFTFLKKNMSKKIMVFFNNCMSVQFYNDLLNYIDIPTYCIHGKKKQNKRLKSFHDFSAAKCAILLCTNVAARGLDIPNVNYIIQYDPPDDSKEYIHRVGRTCRGQDSNGSAIIFLMKHELKFLNYLKFYNIPINQFAYDPNKLINIQSHIQSIVTKNFHLHKMAREAFKSYLNGYITYALKDVFDVNNLNLLLTSKNFGLEVPPKVDLNLKLNVKKKKFK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0097159 (organic cyclic compound binding), GO:0004386 (helicase activity), GO:0008186 (ATP-dependent activity, acting on RNA), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0140098 (catalytic activity, acting on RNA), GO:0042802 (identical protein binding), GO:0003724 (RNA helicase activity), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0051276 (chromosome organization), GO:0071103 (DNA conformation change), GO:0032392 (DNA geometric change), GO:0032508 (DNA duplex unwinding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: CUB-like domain-containing protein (O02360)
Organism: Caenorhabditis elegans
Function: Not known
InterPro domains:
- IPR003366: CUB-like domain (domain) [23-131]
Sequence:
MSARFVAFLLITSNLIILSKTDDDFTCPTIHITKDTGMTGAIPAGATSMTKIPAGTDCTYIFDIPKGFAIKMETSAVYDVSPGDSIKFDYFYISSPAEKEVEYAVNQTLPYEVISKTGNLTFFATYTYIDMTNYQQVIKPTGTYFNATLETDKYFTVQAADNDQVVLKYGSRQTGFVDTSIYEVFVFDGNDILNSKYLGRLTELYRRPQYDVSSTSNTLTLLDLYGMPSDSLLLGNDASTVENMGQYSVFVIDSDKELDGYMGNYELEPDSWYTFICNDCSSFTIGAMTFDRKFENASGYIEVQGMSPTQKLQPVLKYPYSTNSNSSFPQLIPSPMATFHIHNASVTFVVKPGVPQNDFAAAPGQSRSVYSPQIWNPAAEPKFDYTFSDPVKVYNFSINLQTVKLENDGDELDVQVGSVDGLTTLDKKYNKDTKSDAYLSGIGRYLNLKYTGSKTSEVILNFVMIDRLNPDGTTQSPGTTVVPSGSFSTAPIVTSVSTRATRVSSSTAPVVSTVTSTITSQSIVTTNKSSSPITSKTTTSINVSSSTTKSTRPMQSTTTYQKLAQASSTASTTPIPITTQNISTASIATPSTKTPITPSLITTRSSTTKLSPIVITKSSLAYTATPTSAAPSTSALTITTHTTPIPGVLTSKTTSKTVDLTTATQSVQTPISTDPILHHTTPSSFTIGTTQFFTEISTVNPKRLTGSTATSVHVETTTKGTSSLFSAGFLIIVISALTL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Aminoglycoside 2'-N-acetyltransferase (EC 2.3.1.-) (AAC(2')-Ic) (P9WQG9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: May catalyze the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides and confer resistance to aminoglycosides (By similarity). In vitro assays show no significant increase of resistance to aminoglycosides, possibly due to low expression in a heterologous system.
InterPro domains:
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [12-181]
- IPR000182: GNAT domain (domain) [11-162]
Sequence:
MHTQVHTARLVHTADLDSETRQDIRQMVTGAFAGDFTETDWEHTLGGMHALIWHHGAIIAHAAVIQRRLIYRGNALRCGYVEGVAVRADWRGQRLVSALLDAVEQVMRGAYQLGALSSSARARRLYASRGWLPWHGPTSVLAPTGPVRTPDDDGTVFVLPIDISLDTSAELMCDWRAGDVW
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0009084 (glutamine family amino acid biosynthetic process), GO:0006525 (arginine metabolic process), GO:0006526 (arginine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Cadherin domain-containing protein (Q8CAC6)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
InterPro domains:
- IPR050174: Protocadherin/Cadherin-related Cell Adhesion (family) [15-456]
- IPR002126: Cadherin-like (domain) [52-456]
- IPR013164: Cadherin, N-terminal (domain) [27-111]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [133-456]
- IPR020894: Cadherin conserved site (conserved_site) [237-353]
Sequence:
MDLLSGTYIFAVLLACVVFQSGAQEKNYTVREEMPENVLIGDLLKDLNLSLIPDKSLTTPMQFKLVYKTGDVPLIRIEEGTGEIFTTGARIDREKLCAGIVLDARCFYEVEVAVLPDEIFRLVKIRFLIEDINDNAPLFPTTVINISIPENSAINSRYSLPAAIDPDIGINGVQNYQLIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVADTNDNHPIFIEKEIEVSIPENAPIGSSVTQLHATDADIGENARIHFYFSNLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDGGSTPARATVLVNVTDINDNIPSIDIRYIVNPTNGTVLLSENAPLNTKIALITVMDKDSEHNGRVTCFTDHEVPFRLRPVFSNQFLLETAAFLDFESTREYAIKLLAADAGKPPLNQSSMLLIKV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0019953 (sexual reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007283 (spermatogenesis), GO:0048232 (male gamete generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Energy-coupling factor transporter transmembrane protein EcfT (ECF transporter T component EcfT) (Q9X2I1)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (Probable). Expression of the complex plus RibU in E.coli allows riboflavin uptake; uptake does not occur in the absence of RibU or the EcfA1A2T complex.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:23359690}; Multi-pass membrane protein {ECO:0000305|PubMed:23359690}.
InterPro domains:
- IPR003339: ABC/ECF transporter, transmembrane component (family) [16-257]
Sequence:
MRLPTVLIGRYIPVDSIVHRLDPRAKLLGMIFLISAVLIVPNLLFYLVPGLAIFLLMFLSRTGFKIYLAGLRSLWFFLVFAVLVQFFSSSEGEKIFWMITDRAIWSAVYIMLRLVLIILLAENFSATTPPLLSARAIESIFSTFGARKIGHEIGMVMTIAMRFVPVLALEADRILKAQIARGANFERGKFFDRIRALVVIIVPLLISALRKAEELAVAMEARLYTGEPPKTRFKDIKWKPMDTLYVLLTAGVLVLVLFGRYFVDGVFQYGS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0051180 (vitamin transport), GO:0071705 (nitrogen compound transport), GO:0015711 (organic anion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: BZIP domain-containing protein (A7RFN4)
Organism: Nematostella vectensis (Starlet sea anemone)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
InterPro domains:
- IPR040223: PAR basic leucine zipper protein (family) [6-67]
- IPR004827: Basic-leucine zipper domain (domain) [5-68]
- IPR046347: Basic-leucine zipper domain superfamily (homologous_superfamily) [5-65]
Sequence:
AYGRDKDQKYIEKRMKNNLAAKRSREAKRQREIEAMQKTLTLEKENSDLNKEVNKLKKMIARLENKLR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0062013 (positive regulation of small molecule metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0045834 (positive regulation of lipid metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0045184 (establishment of protein localization), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0062012 (regulation of small molecule metabolic process), GO:0046889 (positive regulation of lipid biosynthetic process), GO:0046890 (regulation of lipid biosynthetic process), GO:0010565 (regulation of cellular ketone metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0010565 (regulation of cellular ketone metabolic process), GO:0045923 (positive regulation of fatty acid metabolic process), GO:0019216 (regulation of lipid metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0046889 (positive regulation of lipid biosynthetic process), GO:0042304 (regulation of fatty acid biosynthetic process), GO:0019217 (regulation of fatty acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: (R)-2-hydroxyisocaproyl-CoA dehydratase alpha subunit (EC 4.2.1.157) (Q5U924)
Organism: Clostridioides difficile (Peptoclostridium difficile)
Function: Involved in the reductive branch of L-leucine fermentation. Catalyzes the irreversible beta/alpha-elimination of water from (R)-2-hydroxyisocaproyl-CoA to yield isocaprenoyl-CoA. This beta/alpha-dehydration depends on the reductive formation of ketyl radicals on the substrate generated by injection of a single electron from the ATP-dependent activator protein HadI. The enzyme is specific for the R-isomer.
InterPro domains:
- IPR010327: FldB/FldC dehydratase alpha/beta subunit (family) [37-397]
Sequence:
MSEKKEARVVINDLLAEQYANAFKAKEEGRPVGWSTSVFPQELAEVFDLNVLYPENQAAGVAAKKGSLELCEIAESKGYSIDLCAYARTNFGLLENGGCEALDMPAPDFLLCCNNICNQVIKWYENISRELDIPLIMIDTTFNNEDEVTQSRIDYIKAQFEEAIKQLEIISGKKFDPKKFEEVMKISAENGRLWKYSMSLPADSSPSPMNGFDLFTYMAVIVCARGKKETTEAFKLLIEELEDNMKTGKSSFRGEEKYRIMMEGIPCWPYIGYKMKTLAKFGVNMTGSVYPHAWALQYEVNDLDGMAVAYSTMFNNVNLDRMTKYRVDSLVEGKCDGAFYHMNRSCKLMSLIQYEMQRRAAEETGLPYAGFDGDQADPRAFTNAQFETRIQGLVEVMEERKKLNRGEI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016836 (hydro-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0009072 (aromatic amino acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0006558 (L-phenylalanine metabolic process), GO:1902221 (erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)