lokahq/bioreason-rl huggingface dataset:
Protein: C2H2-type domain-containing protein (Q8BLA2)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
InterPro domains:
- IPR013087: Zinc finger C2H2-type (domain) [29-560]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [27-555]
Sequence:
MVTHDTMSVFCPGTRLPQHPRGYSTEKPYKCEECGKAFRRASHLSQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYTCKECGKAFTQSSQLILHHRIHTGEKPYKCEACGKAFIRSSQLSRHQKVHTGEEPFECKECGKAFTQNSQLTLHQRLHTGEKLYDCKECRKVFTQLSQLILHRRIHTGEKPYECNECGKAFICGSQLSQHRKIHNGEKPYECKECGKAFIRGSLLMQHQRIHTGEKPYKCDECGKAFIRGSQLTQHQRVHTNEKPYECKECGKTFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYKCKECGKNFSRGSELTQHERIHTGEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCSECGKAFARGLLLIQHQRIHTGEKPYQCRECGKAFIRSSQLTQHQRTHTGEKPYECRECGKAFGHGSQLTLHQRVHTGEKPYECKECRKAFTQSSHLSRHQRVHTGEKPYQCKECEKAFTRESQLMRHQRIHIRGKSLDCKECRIDFNHHSQIFI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0071684 (organism emergence from protective structure), GO:0007275 (multicellular organism development), GO:0001824 (blastocyst development), GO:0009790 (embryo development), GO:0035188 (hatching), GO:0009792 (embryo development ending in birth or egg hatching), GO:0001835 (blastocyst hatching), GO:0043009 (chordate embryonic development), GO:0001701 (in utero embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Plasma membrane intrinsic protein 1B (A8MRW1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
InterPro domains:
- IPR000425: Major intrinsic protein (family) [44-261]
- IPR034294: Aquaporin transporter (family) [12-264]
- IPR022357: Major intrinsic protein, conserved site (conserved_site) [112-120]
- IPR023271: Aquaporin-like (homologous_superfamily) [37-273]
Sequence:
MEGKEEDVRVGANKFPERQPIGTSAQSDKDYKEPPPAPLFEPGELASWSFWRAGIAEFIATFLFLYITVLTVMGVKRSPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAVYYIVMQCLGAICGAGVVKGFQPKQYQALGGGANTIAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRNARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIFNKDNAWDDHVMGLLGWTIHWCCTCCSLPRYSHQSHPIQVQKLKLIEFYLKSGFCS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015267 (channel activity), GO:0005372 (water transmembrane transporter activity), GO:0015250 (water channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0051234 (establishment of localization), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0001101 (response to acid chemical), GO:1901700 (response to oxygen-containing compound), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0010033 (response to organic substance), GO:0006810 (transport), GO:1902074 (response to salt), GO:0071702 (organic substance transport), GO:0042044 (fluid transport), GO:0006833 (water transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC 3.1.3.16) (EC 3.1.3.53) (P62207)
Organism: Gallus gallus (Chicken)
Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
InterPro domains:
- IPR006186: Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (domain) [29-299]
- IPR031675: Serine-threonine protein phosphatase, N-terminal (domain) [8-55]
- IPR050341: Serine/threonine-protein phosphatase PP1 catalytic subunit (family) [23-302]
- IPR004843: Calcineurin-like, phosphoesterase domain (domain) [58-250]
- IPR029052: Metallo-dependent phosphatase-like (homologous_superfamily) [1-308]
Sequence:
MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYGGLNSGRPVTPPRTANPPKKR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004722 (protein serine/threonine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Cell wall integrity and stress response component 1 (P87179)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Membrane {ECO:0000269|PubMed:10759889}; Single-pass membrane protein {ECO:0000269|PubMed:10759889}.
InterPro domains:
- IPR002889: Carbohydrate-binding WSC (domain) [31-119]
- IPR051836: Kremen receptor (family) [36-273]
Sequence:
MVFLNSSPFKGRLLFFVYLLIISTRLVAADMNTQYGCYLVDSSLTEQGTFTYLDPAYCYNNICGGSDNIAFVAIRNNQCYCGSTLTATEVSSSLCTTPCPGYGSLMCGGDLYWSVYLTGNGVLQTTVSSSSVSSTTSSSSSSSPSSSSTTTTTSPSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSVPITSSTSSSHSSSSSSSSSSSSSSRPSSSSSFITTMSSSTFISTVTVTPSSSSSSTSSEVPSSTAALALNASKASNHTSLNAGAIVGIVIGCVAFAVVMALCIFLYFYFRRFKIRMSDSANEGKYPSYASELDSRLDPAMMNRKSSESLADSQDYSRKILRVTNLN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015926 (glucosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0009056 (catabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0035556 (intracellular signal transduction), GO:0044248 (cellular catabolic process), GO:0006914 (autophagy), GO:0030242 (autophagy of peroxisome), GO:0007264 (small GTPase mediated signal transduction), GO:0007265 (Ras protein signal transduction), GO:0007266 (Rho protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030427 (site of polarized growth), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0060187 (cell pole), GO:0098590 (plasma membrane region), GO:0051286 (cell tip), GO:0120025 (plasma membrane bounded cell projection), GO:0043332 (mating projection tip), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0031520 (plasma membrane of cell tip), GO:0043231 (intracellular membrane-bounded organelle), GO:0005937 (mating projection)
Protein: Actin-2 (EC 3.6.4.-) (P10984)
Organism: Caenorhabditis elegans
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular location: Cytoplasm, cytoskeleton.
InterPro domains:
- IPR020902: Actin/actin-like conserved site (conserved_site) [105-117]
- IPR043129: ATPase, nucleotide binding domain (homologous_superfamily) [4-376]
- IPR004000: Actin family (family) [4-376]
- IPR004001: Actin, conserved site (conserved_site) [54-365]
Sequence:
MCDDDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITVGNERFRCPEALFQPSFLGMESAGIHETSYNSIMKCDIDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0051301 (cell division), GO:0007275 (multicellular organism development), GO:0030029 (actin filament-based process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0000910 (cytokinesis), GO:1903047 (mitotic cell cycle process), GO:0030036 (actin cytoskeleton organization), GO:0000278 (mitotic cell cycle), GO:0030866 (cortical actin cytoskeleton organization), GO:0006996 (organelle organization), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:0000281 (mitotic cytokinesis), GO:0009792 (embryo development ending in birth or egg hatching), GO:0007010 (cytoskeleton organization), GO:0030865 (cortical cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030017 (sarcomere), GO:0005737 (cytoplasm), GO:0036379 (myofilament), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0098857 (membrane microdomain), GO:0043229 (intracellular organelle), GO:0005865 (striated muscle thin filament), GO:0043228 (non-membrane-bounded organelle), GO:0045121 (membrane raft), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)
Protein: Lutropin subunit beta (Luteinizing hormone subunit beta) (LH-B) (LSH-B) (LSH-beta) (Lutropin beta chain) (P04651)
Organism: Bos taurus (Bovine)
Function: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
Subcellular location: Secreted.
InterPro domains:
- IPR006208: Glycoprotein hormone subunit beta (domain) [27-130]
- IPR018245: Gonadotropin, beta subunit, conserved site (conserved_site) [54-130]
- IPR001545: Gonadotropin, beta subunit (family) [1-133]
- IPR029034: Cystine-knot cytokine (homologous_superfamily) [21-131]
Sequence:
MEMFQGLLLWLLLGVAGVWASRGPLRPLCQPINATLAAEKEACPVCITFTTSICAGYCPSMKRVLPVILPPMPQRVCTYHELRFASVRLPGCPPGVDPMVSFPVALSCHCGPCRLSSTDCGGPRTQPLACDHPPLPDILFL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0046660 (female sex differentiation), GO:1901360 (organic cyclic compound metabolic process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048608 (reproductive structure development), GO:0001541 (ovarian follicle development), GO:0045137 (development of primary sexual characteristics), GO:0007548 (sex differentiation), GO:0061458 (reproductive system development), GO:0046545 (development of primary female sexual characteristics), GO:0008406 (gonad development), GO:0008585 (female gonad development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Glycoprotein hormone alpha 2 (Q58L88)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
InterPro domains:
- IPR052680: Glycoprotein Hormones Alpha Subunit (family) [20-140]
- IPR029034: Cystine-knot cytokine (homologous_superfamily) [30-141]
Sequence:
MPKPWPISTVAEMGSSQLLVLICCIPWLCDSNSMGKDAWLRPGCHKVGNTRKITIPDCVEFTITTNACRGFCESFSVPSIPMMGSSLSVLFKPPKPVVSVGQCCNMMKSEEIQRRVLCIEGIRNVTFNSALSCSCYHCKKD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0140677 (molecular function activator activity), GO:0030545 (signaling receptor regulator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0001664 (G protein-coupled receptor binding), GO:0005179 (hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0048511 (rhythmic process), GO:0007610 (behavior), GO:0007623 (circadian rhythm), GO:0007626 (locomotory behavior), GO:0048512 (circadian behavior), GO:0007622 (rhythmic behavior), GO:0045475 (locomotor rhythm)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140677 (molecular function activator activity), GO:0030545 (signaling receptor regulator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0001664 (G protein-coupled receptor binding), GO:0005179 (hormone activity), GO:0006959 (humoral immune response), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0007530 (sex determination), GO:0010556 (regulation of macromolecule biosynthetic process)
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A1D8PHD2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
InterPro domains:
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [157-625]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [315-327]
- IPR000719: Protein kinase domain (domain) [173-621]
Sequence:
MQEVLFTYHQRSDQPPPPPSQQSHLHASTPTPTPLSNMKRKQSSESDDPFKDRSCKSRKDASTANLLRLQQSLSNSTFIRNSNLSKSYKHNETTEVANNNLHDTTFSQTTETEEFVTPNQLDEQLEVAGRGGRGVVVEEEQREEEEEEEEVTLEVLENMQKLETNFPILATDYRLIDKIGEGTFSTVYKAESLTGKIRLGSDIWKSPPLKRNKRNILNFQQSRKKNPIVALKQIYVTSSPNRIFNELHLLYMLSGNSRVAPLLDVLRFQDQIVAILPYYNHCDFREFYRDLPVKGIKKYLWELFQALDYIHGKGVIHRDLKPTNFLYDPFRGKGVLVDFGLAERENISKNTKPETSTTSSSGTATTTTTATTTTTTTTTTTTNSSTASSSAISTACPCLNKDQKLINRTHTKRLNVKGAYPKNDNRPPRRANRAGTRGFRAPEVLFKCTNQSTKIDIWSAGIIGFSILLRKFPIFNSPTDTDAILELAWIFGYDKMAKCAELHGCGLEISMPEIHKSNGNLIKIMYDFLMQEHINGCFPSDSVVYDTLELINESGEKFVKPVYTIREGISDIEKMKINEDFTKRHDDYKDHKYLMELLYGCFKMDPSKRLSAREILQLPFFHEILQISEDDTQDEFMQQNQTQTQEEEEEDEVILS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0035173 (histone kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0006468 (protein phosphorylation), GO:0018193 (peptidyl-amino acid modification), GO:0016310 (phosphorylation), GO:0018210 (peptidyl-threonine modification), GO:0018107 (peptidyl-threonine phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0005634 (nucleus), GO:1902911 (protein kinase complex), GO:1902554 (serine/threonine protein kinase complex)
Protein: Purine-cytosine permease FCY2 (PCP FCY2) (Cytosine/purine transport protein FCY2) (Fluorocytosine resistance protein 2) (P17064)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: This permease has a broad specificity towards purines, and also transport cytosine and 5-methylcytosine but neither uracil nor thymine.
Subcellular location: Membrane; Multi-pass membrane protein.
InterPro domains:
- IPR012681: Nucleobase cation symporter-1, NCS1 (family) [72-505]
- IPR026030: Purine-cytosine permease Fcy2/21/22 (family) [32-533]
- IPR001248: Purine-cytosine permease (family) [76-494]
Sequence:
MLEEGNNVYEIQDLEKRSPVIGSSLENEKKVAASETFTATSEDDQQYIVESSEATKLSWFHKFFASLNAETKGVEPVTEDEKTDDSILNAASMWFSANMVIASYALGALGPMVFGLNFGQSVLVIIFFNIMGLIFVAFFSVFGAELGLRQMILSRYLVGNVTARIFSLINVIACVGWGIVNTSVSAQLLNMVNEGSGHVCPIWAGCLIIIGGTVLVTFFGYSVIHAYEKWSWVPNFAVFLVIIAQLSRSGKFKGGEWVGGATTAGSVLSFGSSIFGFAAGWTTYAADYTVYMPKSTNKYKIFFSLVAGLAFPLFFTMILGAASAMAALNDPTWKAYYDKNAMGGVIYAILVPNSLNGFGQFCCVLLALSTIANNIPNMYTVALSAQALWAPLAKIPRVVWTMAGNAATLGISIPATYYFDGFMENFMDSIGYYLAIYIAISCSEHFFYRRSFSAYNIDDWDNWEHLPIGIAGTAALIVGAFGVALGMCQTYWVGEIGRLIGKYGGDIGFELGASWAFIIYNILRPLELKYFGR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015205 (nucleobase transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015851 (nucleobase transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0000322 (storage vacuole), GO:0000324 (fungal-type vacuole)