lokahq/bioreason-rl huggingface dataset:
Protein: O-antigen biosynthesis glycosyltransferase WclY (B8QSK0)
Organism: Escherichia coli
Function: Involved in the assembly of the O-repeating unit during O- antigen biosynthesis. N- acetylglucosamine transferase accountable for the alpha-D-GlcNAc-1,4- beta-D-Gal linkage within the O-antigen
Subcellular location: Membrane; Single-pass membrane protein
InterPro domains:
- IPR028098: Glycosyltransferase subfamily 4-like, N-terminal domain (domain) [14-161]
- IPR001296: Glycosyl transferase, family 1 (domain) [171-319]
Sequence:
MKIAYVVSSKKKCGPNIVILNIVKELANKHEMEIFFLDESDDDVFECVNVKSTQIKKASDLKEHLKRFDIIHSSGIRPDALVVLCKVIYRVKCKIITTIHNYVFQDLYYSYGLVKSLIWGLLWCSIWLFFDKLVILSKNADNYYWFLPSAKKNIIYNGIDDNDCLQNKKCNYRKEFNIPDDGILAGSCANLTKCKGIDLVIQTLTKEHKIYYIVAGDGIEKHNLINLVKARKLHERVYFIDFLDEPESFMSQLDVFLMPSRSEGFGLTVLESTKLGIPVITSNIPIFMELFDQMCLTFDIKNPSTLIDVITYAKKNRLHLSQKFHAIFQDRFTSSKMATKYENVYNNLFREVL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0000030 (mannosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0005975 (carbohydrate metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0009311 (oligosaccharide metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0005976 (polysaccharide metabolic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:1903509 (liposaccharide metabolic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0008653 (lipopolysaccharide metabolic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0009103 (lipopolysaccharide biosynthetic process), GO:0009312 (oligosaccharide biosynthetic process), GO:0033692 (cellular polysaccharide biosynthetic process), GO:0000271 (polysaccharide biosynthetic process), GO:0046401 (lipopolysaccharide core region metabolic process), GO:0009244 (lipopolysaccharide core region biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Golgin-84 (Q8SZ63)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in maintaining Golgi structure and in intra- Golgi transport
Subcellular location: Golgi apparatus membrane; Single- pass type IV membrane protein
InterPro domains:
- IPR019177: Golgin subfamily A member 5 (family) [211-515]
Sequence:
MSSWITGLADKAENILNKLDQNAATALQTENATGSADPMRRSMTSSTQSLSTSLKSTLSPVRRSGANSSSSVKSDGGVSVVTKDMRQKMTTSASFSNSPDISANSMDTNELAAFKIALNEITAERDELRLRLEDLNNETEKFDLHQHTQVLEALVKSLSEERDKAVHDYNEAQAANMAYVHSISELETNLAKLQQEYISAAHKLQMQTKETEQQRQELQEYRIKAQRALQAKDSLIAELKAKPTEEGADPNLVSKDSETRFLQIEHESLKQELEHANEELQKARLQLDDYVSQERQRQVELSSARQREETLAKELRQAREHSVTSESDQRVLTQELASLRQQLSNQMAAAATRLQEREQQLQQMRQRLSEEANTGAKSDYETRLKALTQSLVERQSLLERVTSERNALRLQHEKAQTQLQQNMHLVEMESQRGSSRHTMLNSTDDVKAQFPLLMHPSPFDNRVARRFKRALRQADSMGIRVGTFLRRYPMMRVSVIVYVALLHLWVMFVLLSTTPN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0051020 (GTPase binding), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006810 (transport), GO:0006996 (organelle organization), GO:0010256 (endomembrane system organization), GO:0016192 (vesicle-mediated transport), GO:0007030 (Golgi organization), GO:0048193 (Golgi vesicle transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0031985 (Golgi cisterna), GO:0043231 (intracellular membrane-bounded organelle), GO:0005795 (Golgi stack), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0000139 (Golgi membrane), GO:0000138 (Golgi trans cisterna), GO:0097708 (intracellular vesicle)
Protein: Histone H2AX (Q54WG6)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Phosphorylation of H2AX seems to be performed by atr1 and/or possibly dnapkcs, as ATM ortholog is absent in the genome of this organism
Subcellular location: Nucleus. Chromosome
InterPro domains:
- IPR009072: Histone-fold (homologous_superfamily) [22-148]
- IPR002119: Histone H2A (family) [22-142]
- IPR007125: Core Histone H2A/H2B/H3 domain (domain) [31-107]
- IPR032454: Histone H2A, C-terminal domain (domain) [112-145]
Sequence:
MSETKPASSKPAAAAKPKKVIPRVSRTGEPKSKPESRSARAGITFPVSRVDRLLREGRFAPRVESTAPVYLAAVLEYLVFEILELAHNTCSISKKTRITPQHINWAVGNDLELNSLFQHVTIAYGGVLPTPQQSTGEKKKKPSKKAAEGSSQIY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006325 (chromatin organization), GO:0006338 (chromatin remodeling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000793 (condensed chromosome)
Protein: HUWE1-associated protein modifying stress responses 2 (A0A7P0TBJ1)
Organism: Homo sapiens (Human)
Function: Together with HAPSTR1 plays a central regulatory role in the cellular response to molecular stressors, such as DNA damage, nutrient scarcity, and protein misfolding. Regulates these multiple stress response signaling pathways by stabilizing HAPSTR1, but also independently of HAPSTR1
Subcellular location: Nucleus
InterPro domains:
- IPR029196: HUWE1-associated protein modifying stress responses-like (family) [21-271]
- IPR040308: HUWE1-associated protein modifying stress responses (family) [1-273]
Sequence:
MEEQQKEGEAEVAEHWFSKWERQCLAEAEQEEQLPPELQEEAAAELAGLKSEKQKLWHLFQISATAVAQLYKDSGCQQQGLSMWDPFQNAAMAVTSLYKESGDAHQRSFDLGVQVGHQRRIKDVLEWVKKGRSTIRREDLISFLCGKVPPAPPPPRTPRTPPKPPTGVTSQAVATESSSSVDVDLQPFQEAIALHGLSGAMAGISMRSGDSPQDSGVASSGRRKTSFLEDDLNPFDSEELALHLDSGGIRKRTSAQCSDGITDSPIQKRNRMV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0080134 (regulation of response to stress), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:1902532 (negative regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:1901796 (regulation of signal transduction by p53 class mediator), GO:1901797 (negative regulation of signal transduction by p53 class mediator)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Acid stress chaperone HdeA (P0AES9)
Organism: Escherichia coli (strain K12)
Function: Required for optimal acid stress protection. Exhibits a chaperone-like activity only at pH below 3 by suppressing non- specifically the aggregation of denaturated periplasmic proteins. Important for survival of enteric bacteria in the acidic environment of the host stomach. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA
Subcellular location: Periplasm
InterPro domains:
- IPR010486: HNS-dependent expression A/B (family) [11-96]
- IPR024972: HNS-dependent expression A (family) [1-107]
- IPR036831: HNS-dependent expression A superfamily (homologous_superfamily) [30-108]
- IPR038303: HNS-dependent expression A/B superfamily (homologous_superfamily) [22-110]
Sequence:
MKKVLGVILGGLLLLPVVSNAADAQKAADNKKPVNSWTCEDFLAVDESFQPTAVGFAEALNNKDKPEDAVLDVQGIATVTPAIVQACTQDKQANFKDKVKGEWDKIKKDM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044183 (protein folding chaperone), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0051087 (chaperone binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0009268 (response to pH), GO:0071214 (cellular response to abiotic stimulus), GO:0104004 (cellular response to environmental stimulus), GO:0071467 (cellular response to pH), GO:0010447 (response to acidic pH), GO:0071468 (cellular response to acidic pH)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0042597 (periplasmic space), GO:0030313 (cell envelope), GO:0030288 (outer membrane-bounded periplasmic space)
Protein: Hyphal wall protein 2 (Q59PF9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: GPI-anchored cell wall protein required for mating efficiency, biofilm formation, adhesion, filamentous growth, and oxidative stress tolerance. Involved in normal disseminated infection in a mouse systemic candidiasis model
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=localizes to the cell wall of hyphae
InterPro domains:
- IPR025928: Flocculin type 3 repeat (repeat) [221-748]
Sequence:
MRFATTQLATLACFILTAEATFPLRGLFNDAPVDVDLGVYHEESGNNKEQKVDGFNMSPNIKKRTNENNAANVVSTNGGLFITSTKELKTTVVVTSCFNNVCSETSITTPKTAVTATTSKHSTSKPTYTTTSKHSTSHSSTPASTSKHSTSTSTHPATSEHSTSKSTHATSSKHSTSKSSVSVTTSKHSTHDTTSKSFVTPPASSTTSEHTKHKSHKPSKTVVTLTSCSNNACSQSEITTGAIVVTDKETVYTTYCPLTDTETETESTTATTSKHSTHTTTSKHSSVESTSVTSSSKHSVSKSTDVTTSKHSSSESSHATTMKHSTSKHSTHATTSKHSTTESTSGITSKHSTHATSSKYSTVESSSSFASTSESSVPVSSSKSTTFESSISTTTSKHLTLKSSTPASTLEYSTSIPPAPATTSNSLSTKSTTLTTISRSSTSGSSVPNTTRESSTSTTTPNSSSSESKVSSAIPKYSSSEVSSSATTLKSYSTTHSIPTTLVYSSSTSLGFSVTEFRNLTTTSKSSLSTSTTELLTSGTTVRSSTSESSVTSATSIYTSSESTTSSESTTSIETPKSIASKSSSSVTLPKSSTFAWSTSTTTPESSPITLKLSTSKPPKPSATMESSASTTKNSSIQSTSEATTSGSSGVESSVLTATTKSSVPVTTSEWSSVVTTPKSSAPNTTLEHSTSASETSSGSVYTTFDQSTTVITVTSCSDNLCSKTEVTTGVTVITSDTTSYTTYCPLTGTTTVSSALESLVTANKSTSYVGATPIVSSVVSTTPIISSASTTPIISSASTTSVISSASTTSVISNAISNPVSTDVKPTTSSQGTKSTPVDTDSKSTSETTVMVYTTKSVTPTTVESISVAVSSAAQSSIAAISSYEGTGNNMKLSFGVVIAGVAAFAI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0044010 (single-species biofilm formation), GO:0098743 (cell aggregation), GO:0031589 (cell-substrate adhesion), GO:0098630 (aggregation of unicellular organisms), GO:0090609 (single-species submerged biofilm formation), GO:0043709 (cell adhesion involved in single-species biofilm formation), GO:0042710 (biofilm formation), GO:0043708 (cell adhesion involved in biofilm formation), GO:0090605 (submerged biofilm formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0043230 (extracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005618 (cell wall), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0009277 (fungal-type cell wall), GO:1903561 (extracellular vesicle), GO:0030445 (yeast-form cell wall)
Protein: N-acetylglucosamine kinase 1 (Q59RW5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the N-acetylglucosamine catabolic cascade that phosphorylates N-acetylglucosamine (GlcNAc), and allows the unique ability to utilise GlcNAc as carbon source. Converts GlcNAc to GlcNAc- 6-P. Also able to phosphorylate glucose, glucosamine (GlcN), and mannose. Galactose, fructose, N-acetylmannosamine (ManNAc), mannosamine (ManN), galactosamine (GalN), and N-acetylgalactosamine (GalNAc) are not phosphorylated by HXK1. GlcNAc metabolism is closely associated with virulence and morphogenesis, and is involved in the cell wall synthesis. Acts both as a repressor and an activator of genes involved in maintaining cellular homeostasis. Contributes to white-opaque morphological transition and plays a role as a filamentation repressor
Subcellular location: Cytoplasm. Nucleus. Mitochondrion. Note=Localized in cytoplasm and nucleus in a filamentation-inducing medium whereas in 2% GlcNAc, where catabolism is more prominent, a major fraction is seen to be present in cytoplasm. Localizes to mitochondria in non-fermentative carbon sources like ethanol
InterPro domains:
- IPR022673: Hexokinase, C-terminal (domain) [240-490]
- IPR022672: Hexokinase, N-terminal (domain) [41-230]
- IPR043129: ATPase, nucleotide binding domain (homologous_superfamily) [30-491]
- IPR001312: Hexokinase (family) [27-491]
Sequence:
MTETSISGLRGPKSMYFMEIVDVSSQESSVLSSIVESFTSAVSASNLGVYSDEVLCDIKSSLKENSPITMLPNYNVSPTGDEHGQYLVIDLGGSTLRIAVVDISKPHPNLSRSERITIVVEKSWIIGNDFKRIDGEFFKYIGSKINEILMGQNVIDVKSVINTGITWSFPLETTDYNRGKIKHVSKGYTVGEDIYDKDLKMVLEDTLRQEYGLTLDVQSILNDSLAVYSAGCFIDSKMKLAMVLGTGINMCCSLKRSSDIHPSKMLADATLFNCELSLFGQNLCKDFATKYDIIIDKRFAGLSHHFKTFMEPDPITKTLFQPHELMTSGRYLPELTRLVVVDLIEAGEIFQNVDHQQMYQEYGGFSGELICFVHENDDYDDIHDKLCKAYGWTTVGLSDIVCLKEVVSCIIKRAAFIVANAIIAFFKLLGSDELGGDVTIGYVGSVLNYFHKYRRLIVEYVNSAEEAKGIKVDLKLIENSSIIGAAIGAAYHK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity), GO:0019200 (carbohydrate kinase activity), GO:0004396 (hexokinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0046835 (carbohydrate phosphorylation), GO:0016310 (phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: Hyphally regulated cell wall protein 1 (Q5AL03)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: GPI-anchored hyphal cell wall protein required for hyphal growth and virulence. Involved in innate immune cell evasion through conferring resistance to neutrophil killing. Binds kininogen, the proteinaceous kinin precursor, and contributes to trigger the kinin- forming cascade on the cell surface. Production of kinins is often involved in the human host defense against microbial infections
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor
InterPro domains:
- IPR021031: Hyphally-regulated cell wall protein, N-terminal (domain) [12-334]
Sequence:
MKVVSNFIFTILLTLNLSAALEVVTSRIDRGGIQGFHGDVKVHSGATWAILGTTLCSFFGGLEVEKGASLFIKSDNGPVLALNVALSTLVRPVINNGVISLNSKSSTSFSNFDIGGSSFTNNGEIYLASSGLVKSTAYLYAREWTNNGLIVAYQNQKAAGNIAFGTAYQTITNNGQICLRHQDFVPATKIKGTGCVTADEDTWIKLGNTILSVEPTHNFYLKDSKSSLIVHAVSSNQTFTVHGFGNGNKLGLTLPLTGNRDHFRFEYYPDTGILQLRAAALPQYFKIGKGYDSKLFRIVNSRGLKNAVTYDGPVPNNEIPAVCLIPCTNGPSAPESESDLNTPTTSSIETSSYSSAATESSVVSESSSAVDSLTSSSLSSKSESSDVVSSTTNIESSSTAIETTMNSESSTDAGSSSISQSESSSTAITSSSETSSSESMSASSTTASNTSIETDSGIVSQSESSSNALSSTEQSITSSPGQSTIYVNSTVTSTITSCDENKCTEDVVTIFTTVPCSTDCVPTTGDIPMSTSYTQRTVTSTITNCDEVSCSQDVVTYTTNVPHTTVDATTTTTTSTGGDNSTGGNESGSNHGSGAGSNEGSQSGPNNGSGSGSEGGSNNGSGSGSDSGSNNGSGSGSNNGSGSGSNNGSGSGSGSTEGSEGGSGSNEGSNHGSNEGSGSGSGSQTGSGSGSNNGSGSGSQSGSGSGSQSGSESGSNSGSNEGSNPGAGNGSNEGSGQGSGNGSEAGSGQGSGPNNGSGSGHNDGSGSGSNQGSNPGAGSGSGSESGSNAGSHSGSNEGAKTDSIEGFHTESKPGFNTGAHTDATVTGNSVANPVTTSTESDTTISVTVSITSYMTGFDGKPKPFTTVDVIPVPHSMPSNTTDSSSSVPTIDTNENGSSIVTGGKSILFGLIVSMVVLFM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0098743 (cell aggregation), GO:0031589 (cell-substrate adhesion), GO:0098630 (aggregation of unicellular organisms), GO:0042710 (biofilm formation), GO:0043708 (cell adhesion involved in biofilm formation), GO:0090605 (submerged biofilm formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall)
Protein: Cell wall protein IFF3 (Q5A029)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor
InterPro domains:
- IPR031573: GPI-anchored cell wall protein repeat (repeat) [578-693]
- IPR021031: Hyphally-regulated cell wall protein, N-terminal (domain) [12-339]
Sequence:
MQLFQNILVSIALLTQVVFAIEITENKVDRGTVTLNLSDITIYPGASWSIIDNAYTSFVGKLDVRDGAGLYISSTSHLLALQVSLTALLHSITNNGVVSFDSRISRTSSSYDLRGVSFTNNGEMYFAASGEFSSSTALTSASWTNTRLLSFYQNQRTSGTVSLGMPLGSITNNGQVCLNNQVYEQTTQIKGSGCFTANGDSTIYISNVLLAVSPKQNFYLTDKGSSMIVQAVSTTQTFNVYGFGEGNKIGLTIPLMGNLWNSAYAYDTTSGILTLRNLLLEQKFNIGTGYDPSKFQVVTDSGSGIPSTILGSVAYYGRVPERTLPKSCQIPCKPIPEAPGTTPTQYTTTITKTNTAGNTVTESGVVNVSTDKGGSWFTTTSMFPALSTAPSTATVFSSDTIMSTVEPDTTELASLTDIPIETSSVEELLSVMSNWEPSSAPTLSIETPVSSHHSSMQHSSFESSADINTVFSSESAFETASDYIVSTPSSISHSTMVPQSSVSALSVVSESLASAEPSFVVPSESFIFSASSAAPQPSSSTYSVSFTTQFETPSSAGPSLVTSVESNTELISSATQSSDIQTEFTSTWTTTNSDGSVVTESGIISQSGTSLTTLTTFQPATSLVVPPYSVIETEFTSTWTTTNSDSSVATESGVVSQSDTLLTTVTTFPPAPSAIVPEFTSPWKINTSIESSETLTVSASSYETVGESLAAATSSYLSSATVVVAPSESEINTSSSILNNEEIASAPVSDTTSIAEHHDGSLSMTTTEFVNSNSLPSSHSIVTATITSCNKSKCSESVVTYVSSVSCATITVGDSEKNSSIVGNNISSIVGDDVSNTQAITMATSTESATTLTSVSGAKPSVANDATNSVHTTDYTTATTGVQNGSSLSIPSDIPIEISDITPTDSSSSAVTISYENGSNKESIENIKYLTLVVFGLMMFM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0031589 (cell-substrate adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall)
Protein: Cell wall protein IFF6 (Q59XL0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor
InterPro domains:
- IPR021031: Hyphally-regulated cell wall protein, N-terminal (domain) [11-341]
Sequence:
MLLKQIFLPFFVLFNAINAIDIYQNQVSRGTIDLSIGAITIHSGAYWSIIDNAISALVGTLTVQQDAGFYITGLNPLLGLQVELLGVLNSIKNDGIVSFNGLNSLVGPIYNLVGLSFQNNGEFYLSASGVAPPVFSITAADWHNNGLLVLAQAKRTSALANLGFPTGSIENQGSICLFGTAYQQLTSITGSGCISADRDSTIYIFSSLLPIATTQTLYLADRASSIVIQPVTLPATYTVRGFGNGNKVGISLPLLSVPLLGQPAYSYDPSSGVLTLRGLGVGLLSQRFQIGTGYDSSLLEIVTDDGAGLPTTLLGSVRYNGPVPNNAVPASCNCKYVPPSPGTDESSSLSSSTSEQSSSSATSVSASETSDTSSTQESSLSSEVSSTQEPSSSTPEPSSSSETSSTQESSSTEGPSSSTDSSTEASSSESSTAPSSSAEASSSTESSTEEPSSSTEGPSSSQESSSSEESSTQEPSSSTKESSSTEGPSSTEESSSTEGPSSSTDSSTDITSASSTDEQSSSGTGQSSTEDEPIDSTESDTSSATDSSTATDSSATNTDTNSESTDSSTATDTSSTDSNTASSTETNTDVTDSSTDSNTGATESSTATDTNTDATDSSTVSETGATDSSTATDTNTGATESSTDSNTGATDSSTATDTNTSATNTDTNTGSNTATNTDDNTATDTSSTETNTATNTDGTETNTGTTETNTDTSASNTDDNTGSNTATNTGGTDTNTDTNTGGTDTNTGTNTGGTDTKTGTNTATGTNTGATETNTATNTNGNGTNTNTGATDTATNTATGTNTNTGATDTNTNTNTGATVTNTATNTGDVSATKDIPSPTSTDEGSNNGGGSNNGSGSNNGSGNGSGSGSGSGNGSGDGSNNGSGNGSDNGSGSGNGSDNGSGSGSGSDNGSGSGSGSGSGSGNGSGSGSDNGSGSGNGSGSGSGSGSGSDNGSGSGSNNGSGNGSGNGSGSGSDNGSGNGSGSGSGSGSGNGSGNGSGSGSGSGSGNGSGSNNNNGSGSGSGSGNGQDNGIITSSIGQPGSSTSTQGPSSSNSATIPEQANSGNHIKFTLFNGLLIGLVPIVFM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0031589 (cell-substrate adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall)