lokahq/bioreason-rl huggingface dataset:
Protein: DnaJ homolog subfamily C member 16 (Q9Y2G8)
Organism: Homo sapiens (Human)
Function: Plays an important role in regulating the size of autophagosomes during the formation process
Subcellular location: Endoplasmic reticulum membrane; Single-pass type IV membrane protein
InterPro domains:
- IPR013766: Thioredoxin domain (domain) [119-247]
- IPR043361: DnaJ homolog subfamily C member 16, TRX domain (domain) [136-245]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [146-247]
- IPR018253: DnaJ domain, conserved site (conserved_site) [70-89]
- IPR052448: DnaJ Homolog Subfamily C Member 16 (family) [1-741]
- IPR036869: Chaperone J-domain superfamily (homologous_superfamily) [27-137]
- IPR001623: DnaJ domain (domain) [28-104]
Sequence:
MEVRKLSISWQFLIVLVLILQILSALDFDPYRVLGVSRTASQADIKKAYKKLAREWHPDKNKDPGAEDKFIQISKAYEILSNEEKRSNYDQYGDAGENQGYQKQQQQREYRFRHFHENFYFDESFFHFPFNSERRDSIDEKYLLHFSHYVNEVVPDSFKKPYLIKITSDWCFSCIHIEPVWKEVIQELEELGVGIGVVHAGYERRLAHHLGAHSTPSILGIINGKISFFHNAVVRENLRQFVESLLPGNLVEKVTNKNYVRFLSGWQQENKPHVLLFDQTPIVPLLYKLTAFAYKDYLSFGYVYVGLRGTEEMTRRYNINIYAPTLLVFKEHINRPADVIQARGMKKQIIDDFITRNKYLLAARLTSQKLFHELCPVKRSHRQRKYCVVLLTAETTKLSKPFEAFLSFALANTQDTVRFVHVYSNRQQEFADTLLPDSEAFQGKSAVSILERRNTAGRVVYKTLEDPWIGSESDKFILLGYLDQLRKDPALLSSEAVLPDLTDELAPVFLLRWFYSASDYISDCWDSIFHNNWREMMPLLSLIFSALFILFGTVIVQAFSDSNDERESSPPEKEEAQEKTGKTEPSFTKENSSKIPKKGFVEVTELTDVTYTSNLVRLRPGHMNVVLILSNSTKTSLLQKFALEVYTFTGSSCLHFSFLSLDKHREWLEYLLEFAQDAAPIPNQYDKHFMERDYTGYVLALNGHKKYFCLFKPQKTVEEEEAIGSCSDVDSSLYLGESRGKPSCGLGSRPIKGKLSKLSLWMERLLEGSLQRFYIPSWPELD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0050794 (regulation of cellular process), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0051056 (regulation of small GTPase mediated signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)
Protein: Deoxyhypusine hydroxylase (Q59Z14)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR004155: PBS lyase HEAT-like repeat (repeat) [68-289]
- IPR016024: Armadillo-type fold (homologous_superfamily) [68-302]
- IPR011989: Armadillo-like helical (homologous_superfamily) [9-313]
- IPR021133: HEAT, type 2 (repeat) [245-285]
- IPR027517: Deoxyhypusine hydroxylase (family) [13-313]
Sequence:
MSADEVNIDTASLEELRDILINKTGNTKLANRFRALFNLKSVGSEDSDKERAHKAIKYIAECFNDDSELLKHEVAYVLGQTKDLYAAPYLREVLENDNQQCMVRHEAAEALGALGDKESLPLLEKYFKEDPLLEIRQTCELAIERIHWENSEKAKNEVLEKSLYTSIDPAPPLATNDSTSKVEKLKEILNDQDKPLFERYRAMFRLRDIGTDEACLALASGFDDPSALFKHEIAYVFGQMCNPVTVPSLIKVLKDESEAGMVRHEAAEALGSIATDECLPVLQSFLNDSEPVVRDSAIVALDMYEYENSNELEYATVK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0030447 (filamentous growth), GO:0009628 (response to abiotic stimulus), GO:0044010 (single-species biofilm formation), GO:0098743 (cell aggregation), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0098630 (aggregation of unicellular organisms), GO:0090609 (single-species submerged biofilm formation), GO:0009268 (response to pH), GO:0042710 (biofilm formation), GO:0036177 (filamentous growth of a population of unicellular organisms in response to pH), GO:0044011 (single-species biofilm formation on inanimate substrate), GO:0036176 (response to neutral pH), GO:0036178 (filamentous growth of a population of unicellular organisms in response to neutral pH), GO:0090605 (submerged biofilm formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: Early estrogen-induced gene 1 protein (Q78T81)
Organism: Mus musculus (Mouse)
Function: Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions. Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2. Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors. May play a role in estrogen action (By similarity)
Subcellular location: Nucleus. Cytoplasm. Membrane raft
InterPro domains:
- IPR039931: EEIG1/2-like (family) [1-391]
- IPR019448: NT-type C2 domain (domain) [2-152]
Sequence:
MAFLMKKKKFKFQTTFTLEELTAVPFVNGVLFCKVRLLDGGDFVSLSSREEVQENCVRWRKRFTFVCKMSANPATGLLDPCIFRVSVRKELKGGKAYSKLGFTDLNLAEFAGSGSTVRCCLLEGYDTKNTRQDNSILKVTIGMFLLSGDPCFKTPPSTAKSISIPGQDSSLQLTCKGGGTSSGGSSSTNSLTGSRPPKTRPTILGSGLPEEPDQSLSSPEEVFHSGHSRNSSYASQQSKLSGYSTEHSRSSSLSDLTHRRNTSTSSSASGGLSMAVEGPEGMEREHRPSEKPPRPPEKPPRPPRPLHLSDRSFRRKKDSVESHPTWVDDTRIDADDIVEKIMQSQDFTDGSNTEDSNLRLFVSRDGSTTLSGIQLGNRVSSGVYEPVVIESH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0051179 (localization), GO:0032501 (multicellular organismal process), GO:0051234 (establishment of localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035295 (tube development), GO:0009790 (embryo development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0048839 (inner ear development), GO:0006810 (transport), GO:0048513 (animal organ development), GO:0090596 (sensory organ morphogenesis), GO:0048568 (embryonic organ development), GO:0042472 (inner ear morphogenesis), GO:0060872 (semicircular canal development), GO:0048562 (embryonic organ morphogenesis), GO:0048752 (semicircular canal morphogenesis), GO:0007423 (sensory organ development), GO:0042471 (ear morphogenesis), GO:0043583 (ear development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005802 (trans-Golgi network)
Protein: Carboxylesterase 3 (Q6UWW8)
Organism: Homo sapiens (Human)
Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]- carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics
Subcellular location: Endoplasmic reticulum lumen
InterPro domains:
- IPR002018: Carboxylesterase, type B (domain) [33-547]
- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [30-563]
- IPR050309: Type-B Carboxylesterase/Lipase (family) [26-554]
- IPR019826: Carboxylesterase type B, active site (active_site) [216-231]
Sequence:
MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEMVQCLQQKEGEELVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCQAFQEFMGDVFINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPWPQFNQAEQYLEINPVPRAGQKFREAWMQFWSETLPSKIQQWHQKQKNRKAQEDL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0052689 (carboxylic ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0044237 (cellular metabolic process), GO:0097006 (regulation of plasma lipoprotein particle levels), GO:0034381 (plasma lipoprotein particle clearance), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0006805 (xenobiotic metabolic process), GO:0071466 (cellular response to xenobiotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)
Protein: Protein FRA10AC1 (Q70Z53)
Organism: Homo sapiens (Human)
Function: May be involved in pre-mRNA splicing
Subcellular location: Nucleus
InterPro domains:
- IPR050645: Histidine Acid Phosphatase (family) [52-265]
- IPR019129: Folate-sensitive fragile site protein Fra10Ac1 (family) [104-219]
Sequence:
MHGHGGYDSDFSDDERCGESSKRKKRTVEDDLLLQKPFQKEKHGKVAHKQVAAELLDREEARNRRFHLIAMDAYQRHTKFVNDYILYYGGKKEDFKRLGENDKTDLDVIRENHRFLWNEEDEMDMTWEKRLAKKYYDKLFKEYCIADLSKYKENKFGFRWRVEKEVISGKGQFFCGNKYCDKKEGLKSWEVNFGYIEHGEKRNALVKLRLCQECSIKLNFHHRRKEIKSKKRKDKTKKDCEESSHKKSRLSSAEEASKKKDKGHSSSKKSEDSLLRNSDEEESASESELWKGPLPETDEKSQEEEFDEYFQDLFL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0070603 (SWI/SNF superfamily-type complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043233 (organelle lumen), GO:1904949 (ATPase complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0005694 (chromosome)
Protein: Cytosine deaminase (P78594)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR002125: Cytidine and deoxycytidylate deaminase domain (domain) [3-121]
- IPR016193: Cytidine deaminase-like (homologous_superfamily) [5-148]
- IPR016192: APOBEC/CMP deaminase, zinc-binding (binding_site) [55-91]
Sequence:
MTFDDKKGLQVALDQAKKSYSEGGIPIGSCIISSDDTVLGQGHNERIQKHSAILHGEMSALENAGRLPGKTYKDCTIYTTLSPCSMCTGAILLYGFKRVVMGENVNFLGNEKLLIENGVEVVNLNDQECIDLMAKFIKEKPQDWNEDIGE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines), GO:0019239 (deaminase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0009112 (nucleobase metabolic process), GO:0072527 (pyrimidine-containing compound metabolic process), GO:0006206 (pyrimidine nucleobase metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: GRB2-associated-binding protein 3 (Q8BSM5)
Organism: Mus musculus (Mouse)
InterPro domains:
- IPR001849: Pleckstrin homology domain (domain) [5-119]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [1-128]
- IPR046355: GRB2-associated-binding protein 1-4-like (family) [1-594]
Sequence:
MSTGDTVCMGWLIKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSNKPIRVIDLSECTVWKHAGPGFIRKEFQKNFVFIVKTTSRTFYLVAKTEEEMQVWVHSISQVCNFSHLEDGADSMESLSHMPSSFQPSPASSLHTVHVANSALLKDDRNTNSVVTEETRRESEFLFLPDYLILSNCETGRLHHASLPTRCDSWSNSNHSLAQTSFDDVFLDGLQPFISNNLVHPLHHGKVSQDFPSIRPQASLIWNREINGPSRNLMSSSPLLESSLNPTVHVEEKQVSLPSGVKELNIMSNTPPPRPPKPSYLSEQRQDQPLLTGHSSNKKPGYTMVPRRISLSGLDHVGSWKGDVQSQSLRHRDKRLSLNLPCKFSPIYPTASPSAEDSYVPMSPKGTASELRPHCSQDDYIPMSSSMLPELPADLEPPPVNRNLKPQRKSRPPPLDSRNLSTIQEHTSLTRTYTVPCNRTSFLSPQRNGINCARLFSTPSEEEEEEEEEEEEEEEEEKYIQMEEYGTVSSLSRSALSWTKKFSLDYLALDFNSTSPAPVQKKLLLSEEQRVDYVQVDEQKTQALRSTKQEWTDERQSKV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0030097 (hemopoiesis), GO:0030099 (myeloid cell differentiation), GO:0002521 (leukocyte differentiation), GO:0002573 (myeloid leukocyte differentiation), GO:0030225 (macrophage differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Glutamine-binding periplasmic protein (P0AEQ3)
Organism: Escherichia coli (strain K12)
Function: Involved in a glutamine-transport system GlnHPQ
Subcellular location: Periplasm
InterPro domains:
- IPR044132: Glutamine-binding periplasmic protein GlnH, type 2 periplasmic binding protein fold (domain) [26-244]
- IPR001638: Solute-binding protein family 3/N-terminal domain of MltF (domain) [26-246]
- IPR018313: Solute-binding protein family 3, conserved site (conserved_site) [48-61]
- IPR001320: Ionotropic glutamate receptor, C-terminal (domain) [26-245]
Sequence:
MKSVLKVSLAALTLAFAVSSHAADKKLVVATDTAFVPFEFKQGDKYVGFDVDLWAAIAKELKLDYELKPMDFSGIIPALQTKNVDLALAGITITDERKKAIDFSDGYYKSGLLVMVKANNNDVKSVKDLDGKVVAVKSGTGSVDYAKANIKTKDLRQFPNIDNAYMELGTNRADAVLHDTPNILYFIKTAGNGQFKAVGDSLEAQQYGIAFPKGSDELRDKVNGALKTLRENGTYNEIYKKWFGTEPK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0036094 (small molecule binding), GO:0022857 (transmembrane transporter activity), GO:0043167 (ion binding), GO:1901682 (sulfur compound transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0043177 (organic acid binding), GO:0043168 (anion binding), GO:0008514 (organic anion transmembrane transporter activity), GO:0072349 (modified amino acid transmembrane transporter activity), GO:0000099 (sulfur amino acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0031406 (carboxylic acid binding), GO:0016597 (amino acid binding), GO:0015171 (amino acid transmembrane transporter activity), GO:0015179 (L-amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051234 (establishment of localization), GO:0009991 (response to extracellular stimulus), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0072348 (sulfur compound transport), GO:0031667 (response to nutrient levels), GO:0000101 (sulfur amino acid transport), GO:0072337 (modified amino acid transport), GO:0006865 (amino acid transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0015807 (L-amino acid transport), GO:0015804 (neutral amino acid transport), GO:0046942 (carboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0042597 (periplasmic space), GO:0030313 (cell envelope), GO:0030288 (outer membrane-bounded periplasmic space)
Protein: Glucosamine 6-phosphate N-acetyltransferase (E3Q1H1)
Organism: Trypanosoma brucei brucei
Function: Involved in the biosynthesis of UDP-N-acetyl-alpha-D- glucosamine. Catalyzes the formation of N-acetyl-D-glucosamine 6- phosphate from acetyl-coenzyme A (acetyl-CoA) and D-glucosamine 6- phosphate
Subcellular location: Glycosome. Note=Predominantly located in glycosome microbodies in the bloodstream form of T.brucei
InterPro domains:
- IPR000182: GNAT domain (domain) [7-147]
- IPR039143: Glucosamine 6-phosphate N-acetyltransferase-like (family) [5-143]
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [6-144]
Sequence:
MTDIVDLELRVLEESDLSSHLELLGHLTEAPPLSGVELANIADMRRRAGIVTKVFCHQPTGRIVGSASLMIQPKFTRGGRAVGHIEDVVVDPSYRGAGLGKALIMDLCEISRSKGCYKVILDSSEKSLPFYEKLGFRAHERQMRLDL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006040 (amino sugar metabolic process), GO:1901071 (glucosamine-containing compound metabolic process), GO:0006044 (N-acetylglucosamine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome), GO:0020015 (glycosome)