lokahq/bioreason-rl huggingface dataset:
Protein: Aspartate-beta-hydroxylase (A0A096MK70)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Sarcoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004157}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004157}.
InterPro domains:
- IPR039038: Aspartyl/asparaginyl beta-hydroxylase family (family) [1-305]
- IPR007943: Aspartyl beta-hydroxylase/Triadin domain (domain) [50-115]
Sequence:
MAPRKNAKGGGGNSSSSGSGSGSGSPSTGSSGSSSSPGARREAKHGGHKNGRRGGISGGSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGVYDADGDGDFDVDDAKVLLGLKERSTSERTFPPEEAETQAELEEQAPEGAEAQNVEDEVKEQIQSLLQESVHTDHDLEADGPAGEPQSEVEDFLTATDSDDRFEALEPGTVHEDTEDSYHVEETASQNHPNDAEEVMSEQESSDHGEAVTDDGLQQHAEEVRHEDYDEPVYEPSENERIEISDNAIDDSNIISEEINVASVEEQQDTPPDT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055074 (calcium ion homeostasis), GO:0055080 (monoatomic cation homeostasis), GO:0006874 (intracellular calcium ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0051480 (regulation of cytosolic calcium ion concentration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031984 (organelle subcompartment), GO:0099080 (supramolecular complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0016528 (sarcoplasm), GO:0043228 (non-membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0016529 (sarcoplasmic reticulum), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0033017 (sarcoplasmic reticulum membrane)
Protein: Mitochondrial RNA-splicing protein MRS3 (P10566)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: MRS3 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations).
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein.
InterPro domains:
- IPR023395: Mitochondrial carrier protein domain superfamily (homologous_superfamily) [19-314]
- IPR018108: Mitochondrial carrier protein, transmembrane region (repeat) [31-313]
Sequence:
MVENSSSNNSTRPIPAIPMDLPDYEALPTHAPLYHQLIAGAFAGIMEHSVMFPIDALKTRIQSANAKSLSAKNMLSQISHISTSEGTLALWKGVQSVILGAGPAHAVYFGTYEFCKKNLIDSSDTQTHHPFKTAISGACATTASDALMNPFDTIKQRIQLNTSASVWQTTKQIYQSEGLAAFYYSYPTTLVMNIPFAAFNFVIYESSTKFLNPSNEYNPLIHCLCGSISGSTCAAITTPLDCIKTVLQIRGSQTVSLEIMRKADTFSKAASAIYQVYGWKGFWRGWKPRIVANMPATAISWTAYECAKHFLMTY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0005381 (iron ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:1990542 (mitochondrial transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0006811 (monoatomic ion transport), GO:0034755 (iron ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006826 (iron ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)
Protein: Tat (Twin-arginine translocation) pathway signal sequence containing protein (O05446)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
InterPro domains:
- IPR040604: Domain of unknown function DUF5632 (domain) [195-276]
- IPR040833: Domain of unknown function DUF5631 (domain) [304-397]
Sequence:
MVTGQPAAAGAHSLSEGAMTAMQSGSVPPPQATPPITTPPVVSAPTMAAGIEATHGPVDTPANTSGAPPASTGTTGPVAPTVVTAGPVAAPAAPVVGGSAVPAGPLPAYGSDLRPPVVAAPAVPSVPTAPVSGAPVAPSASSAPSAGGALVSPVERAASKAVAGQAGASSSTMAGASALSATAGATAGAVSARAAEQQRLQRIVDAVARQEPRISWAAGLRDDGTTTLLVTDLAGGWIPPHVRLPANVTLLEPTARRRDADVIDLLGAVVAVAAHESNTYVAEPGPDAPALTGDRSARSAIPKVDEFGPTLVEAVRRRDSLPRIAQAIALPAVRKTGVLENEAELLHGCITAVKESVLKAYPSHELTAVGDWMLLAAIEALIDEQDYLANYHLAWYAVTTRRGGSRGFAA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0052200 (response to host defenses), GO:0052572 (response to host immune response), GO:0052553 (modulation by symbiont of host immune response), GO:0052559 (induction by symbiont of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Quick-to-court, isoform L (M9PCM5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
InterPro domains:
- IPR000237: GRIP domain (domain) [490-538]
Sequence:
MANGKPRNLSLQLNGGSDISSSGTSSSSSNNKESSPRTTRTPRTPQTPQTPQTPASGVAASVAETPHSCIRQGNCVKANQVKLSTLHESKISPRTPPVTPDSPSTYLDDDIDSMYSFATTTSGRSTMSCEHPYVARNGTTFSGRKMKYVVHCSNYAGQVGPDYLTPTQRAQRQIRRLKELLCIARQDLEQKDTELLRLTREVVELRLFKASLSSPEERSASSDAVTVREAELKTSQDVSPIVDMVDEGNAKGSPRHLSRQQQQQANHSLQAMQMSAEMQSSYADSGHFEDLTMSSVHSKDSQTQSEACGTATPDGEADVGCGAGGDSASNLENYELQRQELISMYEHRIEELIRSQDSATSDLKRSHNDKVEALLQKLAECNTRYSDMVPDYEQAKQRIRELEKQLEDLQRKLIEHEEKQNKMYLHMYQQGQEAERISRADQALDLAQRQPESKVSINELLHQLQSTQDELENIRTIYRRLLEAQKNRTHVDPEVTLQFLKSAIFYFLTDKENSQGHLQAIESILEFTDAEKQKISAANRTPK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0051020 (GTPase binding), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019098 (reproductive behavior), GO:0032504 (multicellular organism reproduction), GO:0007610 (behavior), GO:0007617 (mating behavior), GO:0007619 (courtship behavior), GO:0060179 (male mating behavior), GO:0008049 (male courtship behavior)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005802 (trans-Golgi network)
Protein: Trehalose-6-phosphate phosphatase (Trehalose-phosphatase) (Q059G6)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Function: Not known
InterPro domains:
- IPR006379: HAD-superfamily hydrolase, subfamily IIB (family) [701-905]
- IPR036412: HAD-like superfamily (homologous_superfamily) [700-981]
- IPR003337: Trehalose-phosphatase (family) [697-981]
- IPR023214: HAD superfamily (homologous_superfamily) [702-902]
- IPR001830: Glycosyl transferase, family 20 (family) [35-980]
Sequence:
MDSMHPDPTPEVPPSLPDLKAQVARLEASHKEKGLPLSGRIIHVMHHLPVEIVRIVPADALESAGTGFLSPPMTPEFKPEDAETTVESADAKWRIHARTAHPALVSGIKSLSETHDQLLVAWTGEVLIQPDNTQSPQQPSQATFSSIASNLLAPFSAGDATPQPQPPPQQGSLMVFGGEFNEADQKEIASELDRFAEAEAKFDPTDRLKYIPVFLPPDVSKGHYEGFCKKTLWPLFHYLLWLDSTATVPSPDPSWLAYQKTNQMFAQRVAQIYKPGDLIICHDYHLLLAPKMIRESLGQVFHPNAGWGTAHPSPSLHHAQRKGFDWESNQQTPTPEKAKGEKIGAFMNHVGTALGNHLGTMEHGLQNEIMIGMFMHTPWPSSEIFRCLPKRREILDGMLGANLVSFQTYSYSRHFVSTCIRVCGYESTPGGVDANGQVTAVGYCPIGIDIKRVVHDRDQPGVLPKMQALRDLYKDKKIIVGREKLDVAKGVYNKLQAFEKFLQVYPEWRGKVVLIQVTTPALSESPKLERMTAELVSHINGTYGSLDFTPVHHYHQALEKDEYFGLLSCADLALITSLRDGMNTTSMEFILCQDKTSKSPLVLSEFMGTAPSFASALQINPHDLLGVAQAINKGLTMRKEEKAERHANLLEGVLAHTSHTWAATILKQLLENVGGEHTAHHTPALDTAQFTDAYKKANKRLLLFDYDGTLTPIVKVPSHAVPTERTRNAIAALCKDPKNVVYLISGRDGDFLEEHWGHLDRLGLSAEHGSFVKQPGEEDFINMTEALDMSWMSEVEEIFKYYTERTTGSTIEVKKASITWHYRNSDPDFGEFQCKQALDLLESSLAPRRPIEVLVGKKNLEVRPLAVNKGEIVRRLMYENPDVDLIFCAGDDKTDEDMFRALRTIFPPGGVVDNNPVVMKPPVAVTSALEPEEVAELPDVELTIRSKGVFATTVGPPAKRTLAGWHVTCPEEVVEAFESLLEEIQVV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0019203 (carbohydrate phosphatase activity), GO:0004805 (trehalose-phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044249 (cellular biosynthetic process), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0009311 (oligosaccharide metabolic process), GO:0005984 (disaccharide metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:0005991 (trehalose metabolic process), GO:0009312 (oligosaccharide biosynthetic process), GO:0046351 (disaccharide biosynthetic process), GO:0005992 (trehalose biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:1990234 (transferase complex)
Protein: Myosin XIX (A0A087WU55)
Organism: Homo sapiens (Human)
Function: Not known
InterPro domains:
- IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [16-176]
- IPR001609: Myosin head, motor domain-like (domain) [35-176]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [30-176]
Sequence:
MLQQVNGHNPGSDGQAREYLREDLQEFLGGEVLLYKLDDLTRVNPVTLETVLRCLQARYMADTFYTNAGCTLVALNPFKPVPQLYSPELMREYHAAPQPQKLKPHVFTVGEQTYRNVKSLIEPVNQSIVVSGESGAGKTWTSRCLMKFYAVVATSPASWESHKIAERIEQRILNSN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0051640 (organelle localization), GO:0071840 (cellular component organization or biogenesis), GO:0140352 (export from cell), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0046907 (intracellular transport), GO:0051656 (establishment of organelle localization), GO:0006810 (transport), GO:0051647 (nucleus localization), GO:0007097 (nuclear migration), GO:0006996 (organelle organization), GO:0010256 (endomembrane system organization), GO:0061024 (membrane organization), GO:0006998 (nuclear envelope organization), GO:0006997 (nucleus organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Glyoxalase I-like protein GILP (EC 4.4.1.5) (C6KSP5)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
InterPro domains:
- IPR029068: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (homologous_superfamily) [52-307]
- IPR004360: Glyoxalase/fosfomycin resistance/dioxygenase domain (domain) [56-176]
- IPR037523: Vicinal oxygen chelate (VOC), core domain (domain) [52-179]
Sequence:
MKLFVVVIFVLFILLKRYKCLSKKKNRCHYFINRDSYHLKKKKCKRKILKCKVDGIEYKVHDLDKSINFYTNVLNFKVNKKEKDNAQLILGDDGAYIKLIQKGEGNFTIGEHSFLGLGVHLKNFDINKTKLYEGKIDEEIDKRPVTPCILPDEDAQVRRFWTNCFITDPDGYGIEVVLQNESDKLDRIRFFTTSTKDAQKFYSDILGMQLVKIQSHLEEISYPWNIYGGMSYYFSSENNSTILQMAYAYDEEELHMGNSLGNLILCSKNLNLIEKKLNENNIEVIKNDKGEILVKDLDGYNVYLKDK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016840 (carbon-nitrogen lyase activity), GO:0016841 (ammonia-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0042180 (cellular ketone metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0006081 (cellular aldehyde metabolic process), GO:0044248 (cellular catabolic process), GO:0006082 (organic acid metabolic process), GO:0006089 (lactate metabolic process), GO:0042182 (ketone catabolic process), GO:0046185 (aldehyde catabolic process), GO:0009438 (methylglyoxal metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0051596 (methylglyoxal catabolic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Os05g0163900 protein (cDNA clone:002-168-H12, full insert sequence) (Q75IR0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Not known
InterPro domains:
- IPR054502: Plant bHLH transcription factor, ACT-like domain (domain) [158-224]
- IPR002912: ACT domain (domain) [156-236]
- IPR045847: Transcription factor AIG1-like (family) [40-250]
- IPR045865: ACT-like domain (homologous_superfamily) [153-209]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [62-123]
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [65-120]
Sequence:
MAACQQQIWQEGKQQQHLHHGGYDDLSSVYRGTVVLPRRQGGLAPEPPPPRPSSSSGRSAAAQATAMTIHSEAERRRRERINAHLATLRRILPDAKQMDKATLLASVVNQVKHLKTRATEATTPSTAATIPPEANEVTVQCYAGGEHTAAARTYVRATVSCDDRPGLLADIAATFRRLRLRPLSADMSCLGGRTRHAFVLCREEEEEEDAAAEARPLKEAVRQALAKVALPETVYGGGGRSKRQRLMMESRYSTAVVHTHVDPQYCWYNSR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: RPGRIP1 like (E1BJB4)
Organism: Bos taurus (Bovine)
Function: Not known
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
InterPro domains:
- IPR035892: C2 domain superfamily (homologous_superfamily) [596-1238]
- IPR000008: C2 domain (domain) [577-898]
- IPR021656: RPGR-interacting protein 1, first C2 domain (domain) [598-738]
- IPR031139: RPGRIP1 family (family) [3-1232]
- IPR041091: RPGRIP1, C-terminal (domain) [1100-1232]
Sequence:
MSGPTDETAGDLPVKDIGLNLFGMGGLQETSTTRTMKSRQAVSRISREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYEQVGGGPKRLGRDVEMEEMIERLQEKVHELERQNEVLKSRLISTKQQLQIQGHRHTPYSYVQSRVNTGRRRVNENAGLQECPRKGIKFQDTDVAETVQTMPTKYSNSLLKEARGEIRNLENVIESQRGQIEELERLAEILKTQLRRKENEIELSLLQLREHQATDQRSNIRDNVELIKLHKQLVEKSNALSVMEGKFIQLQEKQKTLRISHDALMANGDELNLQLKEQRLKCCSLEKQLRSMTFSERRIEELQDRISDLEKERELLKENYDKLYNSAFSAAHEEQWKLKEQQLKIQIAQLETALKSDLTDKTEILDRLKTERDQNEKISQENRQLQLQYLEQKQQLDELKNRMKFYNQESDINADELSEALLLIKAQKSQKNGDLSFLEKVDSKINKDLERSMKELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTQKMENLQQDYELKVEQYVHLLDIRAARIQKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPIVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTVTLEVHQAYSTDYETIAACQLRFHEILEKSGRIFCTASLVGTKGDISNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEQMQWLSHQAPKTAQLSSTDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDDHMCFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVSVPLISLAHDRCISGIFELTDHEKHPAGTIHVILKWKFAYLPPSGCITTEDLGNFRHKEESEVVQRLLPTSSFSTIIAAPTPKPRRLTTKDKKVSFMDITPHQHYETSTLPEDRKEISPEVEHIPEREIDMPTVSHIPKVPQESSVDKVKENTEKTQQGKDDDVSLLSEGQLAERSLTSSEDETEITEELEPEDEGDRSASDSDECIIPGPVSKNIKQPPEKIRIEIIALSLNDSRVTADDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVYYNYSYVIYMDKENNQAKRDILKAILLKQEMPNRSVRFTVVSDPPEDEQDLECEDIGIANVDLADVFREGRDIIEQNIDGTGGSIAQSVPPAIAEIQSLY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0005879 (axonemal microtubule), GO:0005881 (cytoplasmic microtubule), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0097014 (ciliary plasm), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)
Protein: LEM3 (Ligand-effect modulator 3) family / CDC50 family (Q38DJ5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
InterPro domains:
- IPR005045: CDC50/LEM3 family (family) [4-383]
Sequence:
MSFGRLLKQQRLPAWQLNLTPRIVCVILWTIAFICIPLGIFVEFCNRNAKEASFRYDNEPTKCTEETFSLIGGQGTGKRTVCETHFEFVLAETLRQPVYFYYGLTKMYQNHRRYTNSRSGKQLMGADVRSETDANPFVIPGDTMDNTNKPIEFGGRNHTYKDFVYVPVGLVAWSMFNDTFTLFRKEKNGSNPGEVLICNGTDFSRHTNKPLHRSVSHNHCDKNGIAWESDIKKKFLEPKWDGSGPVWTAPRSEYGKPSIESNDTYFNNGWYAGEEGHMIPVVTDEDFMVWMRASPLPNVRKLYRIIRTDLRAGKYVMKIRQNYNTKPYGGEKSFIFLQPSMLGGKLTSLSITYFAVGGLALIFTVLVLFASHVWGHHSFAVVERLLTK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway), GO:0007224 (smoothened signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)