lokahq/bioreason-rl huggingface dataset:
Protein: Heterogeneous nuclear ribonucleoprotein U (A0A1W2PP34)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
InterPro domains:
- IPR035778: Heterogeneous nuclear ribonucleoprotein U, SPRY domain (domain) [16-187]
- IPR003877: SPRY domain (domain) [55-187]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [16-190]
- IPR001870: B30.2/SPRY domain (domain) [1-188]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [218-394]
- IPR043136: B30.2/SPRY domain superfamily (homologous_superfamily) [12-221]
Sequence:
MFTLDVKSNTVFDIITDNCDLHFKISRDRLSASSLTMESFAFLWAGGRASYGVSKGKVCFEMKVTEKIPVRHLYTKDIDIHEVRIGWSLTTSGMLLGEEEFSYGYSLKGIKTCNCETEDYGEKFDENDVITCFANFESDEVELSYAKNGQDLGVAFKISKEVLAGRPLFPHVLCHNCAVEFNFGQKEKPYFPIPEEYTFIQNVPLEDRVRGPKGPEEKKDCEVVMMIGLPGAGKTTWVTKHAAENPGKYNILGTNTIMDKMMVAGFKKQMADTGKLNTLLQRAPQCLGKFIEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQRTQKKAEVEGKDLPEHAVLKMKGNFTLPEVAECFDEITYVELQKEEAQKLLEQYKEESKKALPPEKKQNTGSKKSNKNKSGKNQFNRGGGHRGRGGFNMRGGNFRGGAPGNRGGYNRRGNMPQRGGGGGGSGGIGYPYPRAPVFPGRGSYSNRGNYNRGGMPNRGNYNQNFRGRGNNRGYKNQSQGYNQWQQGVSNFLCALCTLIVF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:0006139 (nucleobase-containing compound metabolic process), GO:0009615 (response to virus), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Glycosyltransferase (Homeodomain-like superfamily protein) (Q7X887)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
InterPro domains:
- IPR001005: SANT/Myb domain (domain) [31-82]
- IPR046955: Myb family transcription factor PHR1-like (family) [19-226]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [30-82]
- IPR017930: Myb domain (domain) [26-86]
- IPR006447: Myb domain, plants (domain) [30-82]
Sequence:
MGKSSGRNGNGSFNGNKFHGVRPYVRSPVPRLRWTPDLHRCFVHAVEILGGQHRATPKLVLKMMDVKGLTISHVKSHLQMYRGGSKLTLEKPEESSSSSIRRRQDSEEDYYLHDNLSLHTRNDCLLGFHSFPLSSHSSFRGGGGGRTKEQQTSESGGYDDDADFLHIKKMNDTTTFLSHHFPKGTEEWREQEHEEEEEDLSLSLSLNHHHWRSNGSSVVSETSEAAVSTCSAPFVSKDCFGSSKIDLNLSISLLGS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Mitochondrial import inner membrane translocase subunit TIM50 (Q38EW0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU365079}; Single-pass membrane protein {ECO:0000256|RuleBase:RU365079}.
InterPro domains:
- IPR004274: FCP1 homology domain (domain) [45-218]
- IPR023214: HAD superfamily (homologous_superfamily) [35-276]
- IPR050365: Mitochondrial import inner membrane translocase subunit TIM50 (family) [44-271]
- IPR036412: HAD-like superfamily (homologous_superfamily) [37-202]
Sequence:
MVRTTRFSRNSSKPLFQQLQLITSYGLFQEYPPIWSLPLPPQQPRDTGKPTLVLDIDETLIHTVGMRNEGSDSVSFSFFLRPHAKEFLAEVRELYEVVFWTAGTASYCSAVMDALEVQVLQLPRSFYNIDELRVEARGGISTKNVNFYALSRTQTLQGHNYMKYLPMLGRPLNRVIVIDSDVRSFPLHPRNGVKIEPFLPNERVLSEYARVVTDEVKYGQVGQRQYEGEMAKVIERGEEEVARLQADHALMDLIPMLRSAASSTDLTHELDHWRTDEYTKCDDFRETMNSLSVTRQKILGNVLKERRNVPIPPLKQHVMNHGFMEEANAAMKLEQMRHTPSRL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome), GO:0020015 (glycosome)
Protein: E3 ubiquitin-protein ligase TRIM47 (EC 2.3.2.27) (Tripartite motif-containing protein 47) (Q8C0E3)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96LD4}. Nucleus {ECO:0000250|UniProtKB:Q96LD4}.
InterPro domains:
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [24-33]
- IPR000315: B-box-type zinc finger (domain) [128-221]
- IPR042780: TRIM47, PRY/SPRY domain (domain) [424-629]
- IPR058030: TRIM8/14/16/25/29/45/65, coiled-coil region (domain) [250-381]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [423-575]
- IPR027370: Zinc finger, RING-type, eukaryotic (domain) [9-38]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [4-82]
- IPR001870: B30.2/SPRY domain (domain) [413-634]
- IPR051051: E3 ubiquitin-protein ligase TRIM/RNF (family) [7-616]
- IPR043136: B30.2/SPRY domain superfamily (homologous_superfamily) [415-593]
- IPR001841: Zinc finger, RING-type (domain) [9-58]
Sequence:
MDGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRSAGGTGGSGGPARCPLCQEPFPDGLQLRKNHTLSELLQLRQGSVPGPMSAPASGSTRGATPEPSAPSAPPPAPEPSAPCAPEQWPAGEEPVRCDACPEGAALPAALSCLSCLASFCSAHLAPHERSPALRGHRLVPPLRRLEESLCPRHLRPLERYCRVERVCLCEACATQDHRGHELVPLEQERALQEVEQSKVLSAAEDRMDELGAGIAQSRRTVALIKSAAVAERERVSQMFAEATATLQSFQNEVMGFIEEGEATMLGRSQGDLRRQEEQRSRLSKARHNLGQVPEADSVSFLQELLALRLALEEGCGPGPGPPRELSFTKSSQVVKAVRDTLISACASQWEQLRGLGSNEDGLQKLGSEDVESQDPDSTSLLESEAPRDYFLKFAYIVDLDSDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWVSVGVMAEGFSPQEPYDRGRLGRNAHSCCLQWNGRGFSVWFCGLEAPLPHAFSPTVGVCLEYADHALAFYAVRDGKLSLLRRLKASRPRRSGALASPTDPFQSRLDSHFSGLFNHRLKPAFFLESVDAHLQIGPLKKSCITVLKRR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Bleomycin hydrolase (EC 3.4.22.40) (A8JV24)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR005700}.
InterPro domains:
- IPR004134: Peptidase C1B, bleomycin hydrolase (family) [1-368]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [2-366]
Sequence:
MKNYNLDEFEFSQAFLFYWDKIERCNYFLNNVVKTAQRGEKVDGRLVSFLLLDPTSDGGQWDMLVNLITKHGLMPKKCFPESFSCESSLRMNAILKSKLREYARNLRVLMEKNPTDEEIACKIQEQMAEIYKVVGICLGIPSETFTWEYYDKSKNYQSIGPVSSLEFYERYVKPHFNVEDKVCLVTDPRPTSSYDQAYTVDCLGNVVGGRPVLYNNQSVELLLAVVTKSLKAGEAVWFGCEVSKRFASKQGIEDVDVHDFKLVFDIDIQTTFSKADRLIYGESAMTHAMVFTAVSVDKSGVAQKLRVENSWGEDRGEKGYLVMNADWFREFGFEVVVDKKYVPEDVLRVFDMDPIVLPAWDPMGTLAQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:0004843 (cysteine-type deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination), GO:0000209 (protein polyubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Armadillo repeat-containing protein LFR (Protein LFR ortholog) (OsLFR) (Q6YTW6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Plays critical roles in both embryo and endosperm development. Required for free nuclei division and cellularization in early endosperm development, by preventing premature cell death in the endosperm. Involved in the regulation of pattern formation and organ differentiation during embryogenesis, by regulating genes involved in the early stages of seed development.
Subcellular location: Nucleus {ECO:0000269|PubMed:32808364}.
InterPro domains:
- IPR016024: Armadillo-type fold (homologous_superfamily) [81-414]
- IPR011989: Armadillo-like helical (homologous_superfamily) [202-449]
- IPR021906: SWI/SNF-like complex subunit BAF250/Osa (family) [121-443]
- IPR033388: SWI/SNF-like complex subunit BAF250, C-terminal (domain) [209-240]
Sequence:
MSHVRSAPAGKSGGGGGSTPAKRGRPFGSTTGSGAAAAAAAAAIGDAAAPAALVGPSLQVLTALSDQNNKRIVLALQSGLKSEILWALNALTVLSFKEKDDLRRDTTPLAKVPGLLDALLQVIDDWRDIAMPKDHTKPPRVRTLGVNTTLSGFGHENVEKVYSDTTTPSDDQTKTADSTVTKKRSAGFLFDEEGLFNVDDEGRTEKQQCAVAASNIIRNFSFMPENETVMVQHRHCLETVFQCLEDQNTEDDELITNMLETLVNLAPVLDLRIFSSSKPSFIKITEKRAVQAIMGMLASSIRVWHCAAAELIGRLIINPDNEPFLLPAIPQIYKRLVDLLSVPAVDAQAAAISALYNVAEVNMDFRLKLASERWAVDRLLKVVKTPHPVPEVCRKASMIVESLVSEPQNRMHLLVHENTFAEILTSEGKYSDTFARILYELTARPSNKVTAGQAIWGNIN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0003006 (developmental process involved in reproduction), GO:0009791 (post-embryonic development), GO:0099402 (plant organ development), GO:0090567 (reproductive shoot system development), GO:0048731 (system development), GO:0048608 (reproductive structure development), GO:0048437 (floral organ development), GO:0048438 (floral whorl development), GO:0048653 (anther development), GO:0048443 (stamen development), GO:0048367 (shoot system development), GO:0061458 (reproductive system development), GO:0048466 (androecium development), GO:0048827 (phyllome development), GO:0009908 (flower development), GO:0048366 (leaf development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: cDNA, FLJ94397, highly similar to Homo sapiens uroplakin 1B (UPK1B), mRNA (B2R9H7)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
InterPro domains:
- IPR008952: Tetraspanin, EC2 domain superfamily (homologous_superfamily) [119-228]
- IPR018499: Tetraspanin/Peripherin (family) [14-250]
Sequence:
MAKDNSTVRCFQGLLIFGNVIIGCCGIALTAECIFFVSDQHSLYPLLEATDNDDIYGAAWIGIFVGICLFCLSVLGIVGIMKSSRKILLAYFILMFIVYAFEVASCITAATQRDFFTPNLFLKQMLERYQNNSPPNNDDQWKNNGVTKTWDRLMLQDNCCGVNGPSDWQKYTSAFRTENNDADYPWPRQCCVMNNLKEPLNLEACKLGVPGFYHNQGCYELVSGPMNRHAWGVAWFGFAILCWTFWVLLGTMFYWSRIEY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0060429 (epithelium development), GO:0030855 (epithelial cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)
Protein: Protein HEATR9 (HEAT repeat-containing protein 9) (A2RTY3)
Organism: Homo sapiens (Human)
Function: Not known
InterPro domains:
- IPR016024: Armadillo-type fold (homologous_superfamily) [149-476]
- IPR011989: Armadillo-like helical (homologous_superfamily) [134-471]
- IPR052873: HEAT repeat-containing protein 9 (family) [1-490]
Sequence:
MAYEKSTDISDVSRSMFLYPWLEYPDKTKELRKAMAPVHLPLSCYQMPKEEFPPSPECWRQHPSKPNSVPYCYFKKPEIYTHWHDLYDQREEREAEKMLRKMRDDCRYIKEVHQTHIKMFHLPMSKLTIKSEMRSRPLEPTQDPLKWQRLRELTKSLESPREDEQFYAAQALGCLRISDKFVMEALQQVAQTGPEKVKYEAYRTLAILGCLNKHVIRALIKQLKEKNEGQRMETLTGLRMALNSWAAVSKDKRTQVGDEGKLVPVLQTLIKKSSSEASLEAALCLGFLRPCSNMVQEFLLQCLCQGLKTQRMKALRMLVKVMHVHSAPVIKAILDQLCSSSVLEDRFEATQMLKTIGLEQIQAQGLEELTFNLLRRKTHNEPFLAVRQAVAQTVEELKLKPTMMNLVEAQLMNPDATARQEAVISLGVLGIRSPQVFHLLLDLLDAENHQAVKKSLQETLILCASIDPWIQNKLKNKVLSVYEAPKTNVKAEPTRFQKEPENPEELTIQDFRLAKLNPLFIAKSITKVGQKKTPAFPPCCSKPRKHRPQVIGPWQPRIKKQLRVLAEIAK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0030097 (hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm)
Protein: Fibronectin type-III domain-containing protein (Q3UVK9)
Organism: Mus musculus (Mouse)
Function: Not known
InterPro domains:
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [30-232]
- IPR003961: Fibronectin type III (domain) [7-236]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [32-238]
- IPR015373: Interferon/interleukin receptor domain (domain) [135-232]
- IPR050650: Type II Cytokine and Tissue Factor Receptors (family) [11-316]
Sequence:
MRPLPLWLPSLLLCGLGAAASSPDSFSQLAAPLNPRLHLYNDEQILTWEPSPSSNDPRPVVYQVEYSFIDGSWHRLLEPNCTDITETKCDLTGGGRLKLFPHPFTVFLRVRAKRGNLTSKWVGLEPFQHYENVTVGPPKNISVTPGKGSLVIHFSPPFDVFHGATFQYLVHYWEKSETQQEQVEGPFKSNSIVLGNLKPYRVYCLQTEAQLILKNKKIRSHGLLSNVSCHETTANASARLQQVILIPLGIFALLLGLTGACFTLFLKYQIRVKYWFQAPPNIPEQIEEYLKDPDQFILEVLDKDGSPKEDSWDSVSIISSPEKERDDVLQTP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0140375 (immune receptor activity), GO:0004896 (cytokine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009615 (response to virus), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0140546 (defense response to symbiont), GO:0051607 (defense response to virus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Protein CUSTOS (A9C3N6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Essential for Spemann-Mangold organizer formation and subsequent anterior head development in the embryo. Inhibits canonical Wnt signaling pathway by antagonizing nuclear import of beta-catenin (ctnnb1) during embryogenesis.
Subcellular location: Nucleus envelope {ECO:0000250|UniProtKB:P0DPK0}.
InterPro domains:
- IPR026694: Protein CUSTOS (family) [1-228]
Sequence:
MSESSSEDENTARLKEAVWSFKPEDVKINGKENNGRQSHRADVSKHEHDGNELGTTPEFRSHVAKKLGTYLDGCISEVCSDTVEPAQSENREDEEGFRLFSSSTPGKWMEQSPPPPPKRRPVPSSSDSDSEMEMRFREAAVSLSDILGPVAQNLSEKTEEKSTKEETEDTVTKMKKKKKRKTSSEESQDKVNHQTEKQSNVEGNQEQTTAGERLKKKKKKKKKKRKKLEKDIKKDE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0031128 (developmental induction), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0060061 (Spemann organizer formation), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0030111 (regulation of Wnt signaling pathway), GO:0030178 (negative regulation of Wnt signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)