Protein: Guanine nucleotide-binding protein subunit gamma 2 (Ggamma-subunit 2) (Heterotrimeric G protein gamma-subunit 2) (AtAGG2) (Q93V47)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the abscisic acid (ABA) and ethylene signaling pathways. Regulates basipetal transport of auxin (IAA) in roots and hypocotyls, and thus modulates root architecture (e.g. lateral root formation). The heterotrimeric G-protein controls defense responses to necrotrophic and vascular fungi probably by modulating cell wall-related genes expression; involved in resistance to Plectosphaerella cucumerina.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17158913, ECO:0000269|PubMed:17220359, ECO:0000269|PubMed:22068106}. Note=Localized to the cell membrane when attached to beta subunit GB1.
InterPro domains:
- IPR015898: G-protein, gamma subunit-like domain (domain) [26-100]
- IPR045878: Guanine nucleotide-binding protein subunit gamma 1/2 (family) [10-99]
Sequence:
MEAGSSNSSGQLSGRVVDTRGKHRIQAELKRLEQEARFLEEELEQLEKMDNASASCKEFLDSVDSKPDPLLPETTGPVNATWDQWFEGPKEAKRCGCSIL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051234 (establishment of localization), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0006950 (response to stress), GO:0009845 (seed germination), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0009791 (post-embryonic development), GO:0006952 (defense response), GO:0099402 (plant organ development), GO:0043207 (response to external biotic stimulus), GO:0010817 (regulation of hormone levels), GO:0009620 (response to fungus), GO:0090351 (seedling development), GO:0048731 (system development), GO:0006810 (transport), GO:0098542 (defense response to other organism), GO:0090696 (post-embryonic plant organ development), GO:0048364 (root development), GO:0048528 (post-embryonic root development), GO:0009914 (hormone transport), GO:0050832 (defense response to fungus), GO:0022622 (root system development), GO:0060918 (auxin transport), GO:0048527 (lateral root development), GO:0009926 (auxin polar transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:1902494 (catalytic complex), GO:0019898 (extrinsic component of membrane), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0012505 (endomembrane system), GO:0098797 (plasma membrane protein complex), GO:0005794 (Golgi apparatus), GO:0019897 (extrinsic component of plasma membrane), GO:1905360 (GTPase complex), GO:0043229 (intracellular organelle), GO:0098562 (cytoplasmic side of membrane), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0009898 (cytoplasmic side of plasma membrane), GO:0005834 (heterotrimeric G-protein complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)