lokahq/bioreason-rl huggingface dataset:
Protein: Probable protein phosphatase 2C 69 (AtPP2C69) (EC 3.1.3.16) (Q8LAY8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
InterPro domains:
- IPR036457: PPM-type phosphatase-like domain superfamily (homologous_superfamily) [25-306]
- IPR000222: PPM-type phosphatase, divalent cation binding (binding_site) [64-72]
- IPR015655: Protein phosphatase 2C (family) [28-279]
- IPR001932: PPM-type phosphatase-like domain (domain) [23-279]
Sequence:
MGYLDLALSYSNQPQTVEAPASGGGLSQNGKFSYGYASSAGKRSSMEDFFETRIDGINGEIVGLFGVFDGHGGARAAEYVKRHLFSNLITHPKFISDTKSAITDAYNHTDSELLKSENSHNRDAGSTASTAILVGDRLVVANVGDSRAVISRGGKAIAVSRDHKPDQSDERERIENAGGFVMWAGTWRVGGVLAVSRAFGDRLLKQYVVADPEIQEEKIDDTLEFLILASDGLWDVFSNEAAVAMVKEVEDPEDSAKKLVGEAIKRGSADNITCVVVRFLEKKSASSSHISSSSSKEAKEMPPLGDLAISSNEAKQVQIGSGNKPENVTNRKPDTASRSTDTLTLERNSVTDKV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004722 (protein serine/threonine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0006952 (defense response), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043207 (response to external biotic stimulus), GO:0043170 (macromolecule metabolic process), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0042742 (defense response to bacterium), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Anaerobic dimethyl sulfoxide reductase chain C (DMSO reductase anchor subunit) (P18777)
Organism: Escherichia coli (strain K12)
Function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the DmsAB dimer to the membrane and stabilizes it.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
InterPro domains:
- IPR007059: DMSO reductase anchor subunit (DmsC) (family) [1-286]
Sequence:
MGSGWHEWPLMIFTVFGQCVAGGFIVLALALLKGDLRAEAQQRVIACMFGLWVLMGIGFIASMLHLGSPMRAFNSLNRVGASALSNEIASGSIFFAVGGIGWLLAMLKKLSPALRTLWLIVTMVLGVIFVWMMVRVYNSIDTVPTWYSIWTPMGFFLTMFMGGPLLGYLLLSLAGVDGWAMRLLPAISVLALVVSGVVSVMQGAELATIHSSVQQAAALVPDYGALMSWRIVLLAVALCLWIAPQLKGYQPAVPLLSVSFILLLAGELIGRGVFYGLHMTVGMAVAS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016661 (oxidoreductase activity, acting on other nitrogenous compounds as donors), GO:0016662 (oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0016054 (organic acid catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0009063 (amino acid catabolic process), GO:0019752 (carboxylic acid metabolic process), GO:1901606 (alpha-amino acid catabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0009065 (glutamine family amino acid catabolic process), GO:0006560 (proline metabolic process), GO:0006527 (arginine catabolic process), GO:0006525 (arginine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: SIT4 phosphatase-associated family protein (F4I6B2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
InterPro domains:
- IPR016024: Armadillo-type fold (homologous_superfamily) [166-461]
- IPR007587: SIT4 phosphatase-associated protein family (family) [1-738]
Sequence:
MFWRMAGLSTASAVEAILDKDSFTLEDLLDEDEIIQECKALNGRLLNFLREKVQVEQLIRYIIEEPLEDVEKKRTFKFPFIACEIFTCEIEMILKTLVEDEELMLLLFSFLEAKETHNSLLAGYFSKVVICLLVRKTIPFMQFIKDHQEILKQLVDLIGITSIMEVLKRLVGTDEHLYSNYTSAMQWIEDTDVLEMIVDKFGSSESPEVHANAAEILCTVARYAPPGLATKLSSPSCTGRLLKHTLEDSRPKSVLVNSLSVCISLLDPKRFTLGTYHIYGRQLTHGSMVTNPETVEGMLGSLGDLLMLLNVSSAEGVLLTTYGKLQPPLGKHRLKIVEFISVLLTVGSEAAEKEVIRLGAVKRVLDLFFEYPYNNFLHHHVENVILSCMESKNSQLVDHLLSECNLIGSILEAEKDSTLTAGDSDKLQPTVPAEGKKPLRIGNIGHLTRISNKLLQLANSNVEIQSHLQENSKWVDWQTDVLSKRNTLENVYSWACGRPTSLHDRSRDSDDDDYHDRDYDVAALANNLSQAFRYGIYSNDDMDEAQGSMERDDEDVYFDDESAEVVISSLRLGDDQESDSLFTNSNWFAFDDDKAANERSMTSAASPSPNADGDGEDDDDVVIGEADEFNATAASSPPVDMETEDSTSKHPSENPSEPEPEKSPAWVEWRETSESTAPPSSNPEETTILSNGDVQIEKEDNDDDDDTDNKSAVKTPGVPGDETTEKLPDESGVEPTENSPKASGIEPTESSPKASGAEVTGNLRDSDPAESHADAKSSEPESPHGTKETEVAAEADTKETEEAVKEPEKVV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0050790 (regulation of catalytic activity), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0051336 (regulation of hydrolase activity), GO:0051174 (regulation of phosphorus metabolic process), GO:0010921 (regulation of phosphatase activity), GO:0031399 (regulation of protein modification process), GO:0019220 (regulation of phosphate metabolic process), GO:0043666 (regulation of phosphoprotein phosphatase activity), GO:0035303 (regulation of dephosphorylation), GO:0035304 (regulation of protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Actin-binding LIM protein 1 (A0A8I5ZVV8)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
InterPro domains:
- IPR032402: Putative adherens-junction anchoring domain (domain) [350-729]
- IPR051618: Actin-binding LIM (family) [90-779]
- IPR003128: Villin headpiece (domain) [711-779]
- IPR001781: Zinc finger, LIM-type (domain) [98-337]
- IPR036886: Villin headpiece domain superfamily (homologous_superfamily) [701-779]
Sequence:
MPSFLGLRCLEKLCSSEKGKGPSPERASLRGSHGRRLVIEDLSVPETPHPARHRHGTVTYLFYLYSSNRGPPELRFSSCDSSVAHPQDPHHSSEKPVIHCHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGDYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKEATCSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGSPYCEKDYQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHPDCKQSTKTEEKLRPTRTSSESIYSRPGSSIPGSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDIERPDLITYEPFYTSGYEDKQDRQSLGESPRTLSPTPSAEGFQDGRDRMIHRSTSQGSINSPVYSRHSYTPTTSRSPQHFHRPGNEPSSGRNSPLPYRPDSRPLTPTYAQAPKHFHVPDQGINIYRKPPIYKQHAALAAQNKASEDIIKFSKFPAAQAPDPNEIPKIETDHWPGPPSLAAIGTDPRRRSSGREEDEEELLRRRQLQEEQLMKLNSGLGQLILKEEMEKENRERASLLASRYDSPLHSASHAPSSKTSSLPGYGKSGLHRPVSTDFAQYNSYGDVSGGVRDYQTLPDGHMPAMRMDRGVSMPNMLEPKIFPYEMLMVTNRGRNKILRDVDRTRLERHLAPEVFWEIFGMSIQEFDKLPLWRRNDMKKKAKLF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0016043 (cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0120036 (plasma membrane bounded cell projection organization), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098794 (postsynapse), GO:0030054 (cell junction), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0099572 (postsynaptic specialization), GO:0043228 (non-membrane-bounded organelle), GO:0098984 (neuron to neuron synapse), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0032279 (asymmetric synapse), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)
Protein: WRKY transcription factor WRKY76 (OsWRKY76) (Q6IEK5)
Organism: Oryza sativa subsp. indica (Rice)
Function: Transcription repressor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Regulates, probably indirectly, the activation of defense-related genes during defense response (By similarity). Modulates plant innate immunity against X.oryzae pv. oryzae (Xoo) (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q6QHD1, ECO:0000255|PROSITE-ProRule:PRU00223}.
InterPro domains:
- IPR044810: WRKY transcription factor, plant (family) [53-322]
- IPR003657: WRKY domain (domain) [160-226]
- IPR036576: WRKY domain superfamily (homologous_superfamily) [152-227]
Sequence:
MDAAWRGGVGCSPVCLDLCVGLSPVREPSAARHELLDRPAGCRGGGDSKSMTNDEAKILEAKVTQMSEENRRLTEVIARLYGGQIARLGLDGSASPPRPVSPLSGKKRSRESMETANSCDANSNRHQGGDADHAESFAADDGTCRRIKVSRVCRRIDPSDTSLVVKDGYQWRKYGQKVTRDNPSPRAYFRCAFAPSCPVKKKVQRSAEDSSLLVATYEGEHNHPHPSPRAGELPAAVGGAGGSLPCSISINSSGPTITLDLTKNGGAVQVVEAAHPPPPPDLKEVCREVASPEFRTALVEQMASALTSDPKFTGALAAAILQKLPEF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003682 (chromatin binding), GO:0003700 (DNA-binding transcription factor activity), GO:1990841 (promoter-specific chromatin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:1901700 (response to oxygen-containing compound), GO:0043207 (response to external biotic stimulus), GO:0010033 (response to organic substance), GO:0009620 (response to fungus), GO:0009617 (response to bacterium), GO:0014070 (response to organic cyclic compound), GO:0009751 (response to salicylic acid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Probable LRR receptor-like serine/threonine-protein kinase At1g63430 (EC 2.7.11.1) (C0LGH8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
InterPro domains:
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [339-621]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [26-265]
- IPR013210: Leucine-rich repeat-containing N-terminal, plant-type (domain) [25-65]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [364-569]
- IPR001611: Leucine-rich repeat (repeat) [95-140]
- IPR000719: Protein kinase domain (domain) [360-642]
Sequence:
MRSKYFCSLALVLGLFFVSCDGFASNEVQALRRFKEAIYEDPLLVMSNWNDPNSDPCDWTGIYCSPSKDHVIKINISASSIKGFLAPELGQITYLQELILHGNILIGTIPKEIGNLKNLKILDLGNNHLMGPIPAEIGSLSGIMIINLQSNGLTGKLPAELGNLKYLRELHIDRNRLQGSLLVAGASGYQSKVYSSNSSANIAGLCKSLKVADFSYNFFVGNIPKCLENLPRTSFQGNCMQNKDLKHRSSSQCANAQLVKTHGSPSAAPKHQSAQMVAKHHRASKPKWLLALEIVTGSMVGLLLLVALFSAVHRWNNRSTLIIPWKKSSSEKEKFTVYVDSEMLKDVSRLTRQELEVACEDFSNIIGLSADSQIYKGTLKGGSEIAVISLCVKEEDWTGYLELYFQREVADLARLNHENTAKLLGYCKEISPFTRMLVFEYASNGTLYEHLHYGEAALVSWARRMKIVIGIARGLKYLHMELDPPFTISELSSNAIYLTEDFTPKLVDFECWKTILARSEKNLRNISSQGSICVLPNGMESRYLDVSGNIYAFGILLLEIVSGRPPYCKDKGFLIEWAKEFLEAPEAMSGLVDPELKHFNQEDLETVCEVASQCLNRDPTNNNNNHNKPSVQELCETLESRISLSISAELRSSSLAWAELALDS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0032502 (developmental process), GO:0050896 (response to stimulus), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0009605 (response to external stimulus), GO:0009856 (pollination), GO:0048856 (anatomical structure development), GO:0044706 (multi-multicellular organism process), GO:0042221 (response to chemical), GO:0003006 (developmental process involved in reproduction), GO:0010183 (pollen tube guidance), GO:0042330 (taxis), GO:0048868 (pollen tube development), GO:0006935 (chemotaxis), GO:0050918 (positive chemotaxis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Diuretic hormone 44 receptor 2, isoform A (IP10431p) (Q4V3E9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
InterPro domains:
- IPR001879: GPCR, family 2, extracellular hormone receptor domain (domain) [57-150]
- IPR017983: GPCR, family 2, secretin-like, conserved site (conserved_site) [84-418]
- IPR000832: GPCR, family 2, secretin-like (family) [161-414]
- IPR036445: GPCR family 2, extracellular hormone receptor domain superfamily (homologous_superfamily) [43-169]
- IPR050332: G-protein coupled receptor 2 (family) [51-451]
- IPR017981: GPCR, family 2-like, 7TM (domain) [161-415]
- IPR002001: GPCR, family 2, diuretic hormone receptor (family) [107-462]
Sequence:
MADDDLRALVDSLDDASQEDLAKVIANFSVDMLQRASALIGAQQGSSGGQLQNRTLQCQQQQQREEEQASLEALASGGKRILQCPSSFDSVLCWPRTNAGSLAVLPCFEEFKGVHYDTTDNATRFCFPNGTWDHYSDYDRCHQNSGSIPVVPDFSPNVELPAIIYAGGYFLSFATLVVALIIFLSFKDLRCLRNTIHANLFLTYITSALLWILTLFLQVITTESSQAGCITLVIMFQYFYLTNFFWMFVEGLYLYTLVVQTFSSDNISFIIYALIGWGCPAVCILVWSIAKAFAPHLENEHFNGLEIDCAWMRESHIDWIFKVPASLALLVNLVFLIRIMWVLITKLRSAHTLETRQYYKASKALLVLIPLFGITYLLVLTGPEQGISRNLFEAIRAFLISTQGFFVALFYCFLNSEVRQTLRHGFTRWRESRNIHRNSSIKNRRHRASKDYSLRSRTESLRLTSTSPIPTGHYE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0009755 (hormone-mediated signaling pathway), GO:0070887 (cellular response to chemical stimulus), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0006970 (response to osmotic stress), GO:0071495 (cellular response to endogenous stimulus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0032870 (cellular response to hormone stimulus), GO:0071310 (cellular response to organic substance), GO:0009651 (response to salt stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: NADH-cytochrome b5 reductase (EC 1.6.2.2) (Q95T90)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
InterPro domains:
- IPR001834: NADH:cytochrome b5 reductase-like (family) [31-258]
- IPR017938: Riboflavin synthase-like beta-barrel (homologous_superfamily) [49-168]
- IPR001433: Oxidoreductase FAD/NAD(P)-binding (domain) [191-260]
- IPR017927: FAD-binding domain, ferredoxin reductase-type (domain) [54-166]
- IPR001709: Flavoprotein pyridine nucleotide cytochrome reductase (domain) [106-240]
- IPR008333: Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain (domain) [59-165]
- IPR039261: Ferredoxin-NADP reductase (FNR), nucleotide-binding domain (homologous_superfamily) [152-262]
Sequence:
MARIVESNFVPLAVGVVAVLAGALIVHYLLNKKSTKPRREPNRTARLRTLVDPNDKYLLPLIEKENLSHDTRRFQFGLPSKQHVLGLPVGQHIHLIATIDNELIIRPYTPISSDEDVGYVDLVVKVYFKDSHPKFPAGGKMTQHLEQLELGDKISFRGPSGRLQYLGNGTFSIKKLRKDPPKHVTAKRVNMIAGGTGITPMLQLAREVLKRSDKDKTELALLFANQSEKDILLRAELDELAQKHPDQFKIWYTVDKANEGELQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0016653 (oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032879 (regulation of localization), GO:0010883 (regulation of lipid storage)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0012505 (endomembrane system)
Protein: Evasin-1 (EVA1) (P0C8E7)
Organism: Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)
Function: Salivary chemokine-binding protein which shows chemokine neutralizing activity and binds to host chemokines CCL3, CCL4 and CCL18. Binds to CCL3 with 1:1 stoichiometry.
Subcellular location: Secreted {ECO:0000305}.
InterPro domains:
- IPR045797: Evasins Class A (family) [32-104]
Sequence:
MTFKACIAIITALCAMQVICEDDEDYGDLGGCPFLVAENKTGYPTIVACKQDCNGTTETAPNGTRCFSIGDEGLRRMTANLPYDCPLGQCSNGDCIPKETYEVCYRRNWRDKKN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019955 (cytokine binding), GO:0019956 (chemokine binding), GO:0019957 (C-C chemokine binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0023057 (negative regulation of signaling), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0040013 (negative regulation of locomotion), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0040012 (regulation of locomotion), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:2000145 (regulation of cell motility), GO:0010469 (regulation of signaling receptor activity), GO:0050922 (negative regulation of chemotaxis), GO:0010646 (regulation of cell communication), GO:0050920 (regulation of chemotaxis), GO:0044092 (negative regulation of molecular function), GO:0009966 (regulation of signal transduction), GO:0032101 (regulation of response to external stimulus), GO:0051098 (regulation of binding), GO:2000146 (negative regulation of cell motility), GO:0032102 (negative regulation of response to external stimulus), GO:0051100 (negative regulation of binding), GO:0030334 (regulation of cell migration), GO:0043393 (regulation of protein binding), GO:0030336 (negative regulation of cell migration), GO:1900120 (regulation of receptor binding), GO:0032091 (negative regulation of protein binding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)