Protein: Palmitoyltransferase ZDHHC1 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 1) (Q8R0N9)
Organism: Mus musculus (Mouse)
Function: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:23687301}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8WTX9}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000250|UniProtKB:Q8WTX9}.
InterPro domains:
- IPR001594: Palmitoyltransferase, DHHC domain (domain) [129-281]
- IPR039859: Palmitoyltransferase PFA4/ZDHHC16/ZDHHC20/ERF2-like (family) [54-298]
Sequence:
MNICNKPSNKTAPEKSVWTAPSQDSGPSPELQGQRSRRNGWSWPPHPLQIVAWLLYLFFAVIGFGVLVPLLPHHWVPAGYACMGAIFAGHLVVHLTAVSIDPADANVRDKSYSGPLPIFNRSQHAHVIEDLHCNLCDVDVSARSKHCSACNKCVCGFDHHCKWLNNCVGERNYRLFLHSVASALLGVLLLVLVATYVFVEFFVNPMRLRTNQHFEVLKNHTDVWFVFLPAAPVETQAPAILALAALLILLGLLSTALLGHLLCFHIYLMWHKLTTYEYIVQHRPAQEAKETHKELESCPRKVRSIQEMEFYMRTFSHVRPEPSGQARTAALNANPSQFLATQGQVEPPLPSSSDTLALPPRIQPQKKRKRRVYRLPRSGVLDRELPLPRLRETGTPSRRSSSSSDSTSASPVHAGGSAGAYYSASAESMEEIPVAQTRLGSAALGAPGARGRESGLALQARSPAVFVSPSSGEPGTPGGGDGLP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016409 (palmitoyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0006807 (nitrogen compound metabolic process), GO:0048583 (regulation of response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:0002831 (regulation of response to biotic stimulus), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0019538 (protein metabolic process), GO:0006952 (defense response), GO:0032101 (regulation of response to external stimulus), GO:0044249 (cellular biosynthetic process), GO:0009615 (response to virus), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0031347 (regulation of defense response), GO:0009059 (macromolecule biosynthetic process), GO:0043412 (macromolecule modification), GO:0140546 (defense response to symbiont), GO:0051607 (defense response to virus), GO:0140374 (antiviral innate immune response), GO:0050688 (regulation of defense response to virus), GO:0034645 (cellular macromolecule biosynthetic process), GO:0042157 (lipoprotein metabolic process), GO:0050691 (regulation of defense response to virus by host), GO:0006497 (protein lipidation), GO:0043543 (protein acylation), GO:0042158 (lipoprotein biosynthetic process), GO:0002230 (positive regulation of defense response to virus by host), GO:0018345 (protein palmitoylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0012506 (vesicle membrane), GO:0097708 (intracellular vesicle)