lokahq/bioreason-rl huggingface dataset:
Protein: 50S ribosomal protein L17, putative (Q57YI7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
InterPro domains:
- IPR036373: Large ribosomal subunit protein bL17 superfamily (homologous_superfamily) [52-166]
- IPR000456: Large ribosomal subunit protein bL17 (family) [54-190]
Sequence:
MLRITLLVVGRAPPVIGCTRKARYAGIDDNPTITYKPWDTTEPLMADYGWTRGKLPKFRARSPFHRQQIARRMVTEMIRKDYCIVGGARAPALRILADHVVELAKAGDTDSRQQLAYFLHDPLMVDKAFDEYPRRFKDMNAKYAMMTRLKSRRRTDAVAMYFVEYKNRDMSDNHKGEDYSAGPERFFLPPRIVETEKGIQRPPHMQMAFDRWASKFKTEEFHHWWRLRHAKLRYWGVRNVPHPSDVDPLWTEKEEEEWHNEMLANTGEYEDLDLDDESYTAAGEGGEPSPAGDGPQPQRVG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0140053 (mitochondrial gene expression), GO:0043043 (peptide biosynthetic process), GO:0032543 (mitochondrial translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0044391 (ribosomal subunit), GO:0000313 (organellar ribosome), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0005762 (mitochondrial large ribosomal subunit), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005761 (mitochondrial ribosome), GO:0000315 (organellar large ribosomal subunit), GO:0043231 (intracellular membrane-bounded organelle), GO:0005759 (mitochondrial matrix), GO:0015934 (large ribosomal subunit), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005840 (ribosome)
Protein: Aldo-keto reductase family 1 member C4 (Q1HE49)
Organism: Sus scrofa (Pig)
Function: Not known
InterPro domains:
- IPR036812: NAD(P)-dependent oxidoreductase domain superfamily (homologous_superfamily) [2-322]
- IPR023210: NADP-dependent oxidoreductase domain (domain) [18-299]
- IPR044482: Aldo-keto reductase family 1 member C (family) [5-307]
- IPR018170: Aldo/keto reductase, conserved site (conserved_site) [44-282]
- IPR020471: Aldo-keto reductase (family) [1-322]
Sequence:
MALNRCVKLNDGHLMPVLGLGTLVSEGVPKSKAGEATRVAIEVGYRHIDAAYVYENEEEVGSALREKIADGTVKREELFYTTKLWATFFRPELVRPALERSLKKLRLDYVDLFIIHVPITMKPGEELLPKDASGKVIFDTVDLRDTWAALEKCKDAGLTKSIGVSNFNHKQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLEFCKSKDIVLVAYSALGSQRNSKWVEESNPYLLEDPVLNAIAKKHNRSPAQVALRYQLQRGVVVLAKSFNEQRIKENFQVFDFELPSEDMKTIDGLNQNLRYFKLLFAVDHPYYPYSEEY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004033 (aldo-keto reductase (NADP) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006633 (fatty acid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0033559 (unsaturated fatty acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0046456 (icosanoid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0006636 (unsaturated fatty acid biosynthetic process), GO:0006692 (prostanoid metabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0006690 (icosanoid metabolic process), GO:0006693 (prostaglandin metabolic process), GO:0046457 (prostanoid biosynthetic process), GO:0001516 (prostaglandin biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Growth hormone (H6ULW9)
Organism: Gallus gallus (Chicken)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
InterPro domains:
- IPR018116: Somatotropin hormone, conserved site (conserved_site) [78-206]
- IPR034975: Somatotropin (family) [35-214]
- IPR001400: Somatotropin/prolactin (family) [4-214]
- IPR009079: Four-helical cytokine-like, core (homologous_superfamily) [20-214]
Sequence:
MAPGSWFSPLLIAVVTLGLPQEAAATFPAMPLSNLFANAVLRAQHLHLLAAETYKEFERTYIPEDQWYTNKNSQAAFCYSETIPAPTGKDDAQQKSDMEVVRFSLVFIQSWLTPVQYLSKVFTNKLVFGTSDRVFEKLKDLEEGIQALMRELEDRSPRGPQLLRPTYDKFDIHLRNEDALLKNYGLLSCFKKDLHKVETYLKVMKCRRFGESNCTI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity), GO:0097153 (cysteine-type endopeptidase activity involved in apoptotic process)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0035295 (tube development), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009888 (tissue development), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0048731 (system development), GO:0060255 (regulation of macromolecule metabolic process), GO:0048608 (reproductive structure development), GO:0061458 (reproductive system development), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0010628 (positive regulation of gene expression), GO:0060066 (oviduct development), GO:0060429 (epithelium development), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0042981 (regulation of apoptotic process), GO:0043066 (negative regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Succinate-CoA ligase ADP-forming subunit beta (Q5T9Q5)
Organism: Homo sapiens (Human)
Function: Not known
InterPro domains:
- IPR017866: Succinyl-CoA synthetase, beta subunit, conserved site (conserved_site) [246-270]
- IPR005811: ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain (domain) [251-298]
- IPR016102: Succinyl-CoA synthetase-like (homologous_superfamily) [229-298]
- IPR013815: ATP-grasp fold, subdomain 1 (homologous_superfamily) [21-93]
- IPR013650: ATP-grasp fold, succinyl-CoA synthetase-type (domain) [21-192]
Sequence:
SGRGHPSEPPASDGPAGCCSGSKDVVIKAQVLAGGRGKGTFESGLKGGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGPVLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENMVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0035383 (thioester metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0006637 (acyl-CoA metabolic process), GO:0019693 (ribose phosphate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0009117 (nucleotide metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0034032 (purine nucleoside bisphosphate metabolic process), GO:0006104 (succinyl-CoA metabolic process), GO:0033865 (nucleoside bisphosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0033875 (ribonucleoside bisphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Plasmodium RESA N-terminal domain-containing protein (Q8IFM0)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
InterPro domains:
- IPR044885: Plasmodium RESA, N-terminal helical domain superfamily (homologous_superfamily) [176-307]
- IPR019111: Plasmodium RESA, N-terminal (domain) [174-297]
Sequence:
MKFFNGSSFSNSNGFMDSKNLKNSAIFSFDEEEKKTASRSFLSSLLSKRMVIPMLGVLYVVLLNVCLHNGSNTSTNVQFNNNVGKRILSEGQSTDEYSESSSEYVENPVIGSTFMLPNENRLNTIGNLFEGEKYNILEDTQKLIDDINKFRYNSNYSPIPYPEQYNPVDYNKADFVLDKYIDNLGYCKGDTIKAMEIIWEATMNNERRKYAATKRSMLRYYDDLKRKRIIRPKTYTNKLNSCNQIMESSEKKIESHLSEMFNKWFKQKSLFLDDFNRFITACRIGWKTVSNAVQHQCDTIMRSKNFIDI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0051701 (biological process involved in interaction with host), GO:0044406 (adhesion of symbiont to host), GO:0044650 (adhesion of symbiont to host cell), GO:0020035 (adhesion of symbiont to microvasculature)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell)
Protein: Protein interacting with Ttk69 and Sin3A, isoform C (Q9VYL7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
InterPro domains:
- IPR044882: Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily (homologous_superfamily) [545-604]
- IPR022750: Interferon regulatory factor 2-binding protein 1/2-like, zinc finger (domain) [6-57]
- IPR057414: Interferon regulatory factor 2-binding protein 1/2-like, C3HC4 zinc finger domain (domain) [531-603]
Sequence:
MSLQTKRQHCYLCDLPRMPWAMINDFSEAVCRGCVNYEGADRIEAVLDAARQMKRLHPASKQQRSHENGEVSAAAAAAVVLQQQQQLQVGPVPGQGPGSHRGGGGGGPPGAPPGSGGPGPSGAGSLSSLGNAVAAAAAAAAVHHHHQMPYQMPVPRIGPPLDYPVKLEDAPGGGVRPVRISHMTPHHLPPNATRGGGGAPGGGVPTAGSGGGSLPPALSVNLKRPPSEDVDVDVSQQQQQSGHGLAPDGSAGNSLSAGGGVSGGCPPGIKRSAMDDPSGVGGRPPLTRGESLPAAVSYVPERQLSGLRDKQQPVRAPSFDASTFKAEHMSPASRRNGSSPPSGPLPPRSVHSPNSSGSSSGRRSSGSRHVSSTTVTSSEVGGSNPGQAVVAGGLGGGGGGGPGSNAASGQLGGPSGGSGQLSCTSGGPGGSASSGSGGNGAIGPASMAPNSVAGDGSPAGGNGPSGSNGSGGSVNPGPGSSGSQGGGGGGTPLASGGGSAGSGGLGGAPGSSAASNSAAAAAAAAAQNATLKCTLCQERLEDTHFVQCPSVNHHKFCFPCSRESIKRQNGLGNEVYCPSGDRCPLANSVIPWAFMQGEITTILGEEVKVKKERES
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0034399 (nuclear periphery), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0005700 (polytene chromosome)
Protein: Regulator of microtubule dynamics protein 3 (RMD-3) (mRMD-3) (Protein FAM82A2) (Protein FAM82C) (Q3UJU9)
Organism: Mus musculus (Mouse)
Function: Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q96TC7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q96TC7}. Cytoplasm {ECO:0000250|UniProtKB:Q96TC7}. Nucleus {ECO:0000250|UniProtKB:Q96TC7}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q96TC7}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q96TC7}. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. {ECO:0000250|UniProtKB:Q96TC7}.
InterPro domains:
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [252-452]
- IPR049039: Regulator of microtubule dynamics protein 1-3, alpha helical repeats (repeat) [237-469]
Sequence:
MSRLGALGGSRAGLGLLLGTAAGLGFLCVLYSQRWKRTQRHGRSHSLPNSLDYAQASERGRQVTQFRAIPGEAGDAAILPSLSQEGQEKVLDRLDFVLTSLMALRREVEELQRSLQGLAGEIVGEVRSHIEENQRVARRRRFPFARERSDSTGSSSVYFTASSGAALTDAESEGGYTTANAESDYERDSDKESGDAEDEVSCETVRMGRKDSLDLDVEAASSPAAAALEEDDSSGREDVQLVLLQADELHQGSKQDKREGFQLLLNNKLAYGSRQDFLWRLARAYSDMSDLTEEESGKKSYALNGKEEAEAALKKGDESAACHLWYAVLCGQLAEHEGISKRIQSGFSFKEHVDKAIELQPEDPRGHFLLGRWCYQVSHLNWLEKKTATALFESPLSATVQDALQSFLKAEELQPGFSKAGRVYISKCYRELGKNSEARKWMKLAQELPDVTNEDSAFQKDLEELEVILG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055074 (calcium ion homeostasis), GO:0055080 (monoatomic cation homeostasis), GO:0006874 (intracellular calcium ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Smtnl protein (Q5BL23)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
InterPro domains:
- IPR001715: Calponin homology domain (domain) [383-490]
- IPR036872: CH domain superfamily (homologous_superfamily) [373-493]
- IPR050540: F-actin Monooxygenase Mical (family) [245-490]
Sequence:
MDAGPLASVAEGSPEGETVCAALARYETTLRDAVREIHVDVSAFKLGIERRLEEAIHVSGPLGRAVAQLQQENRQLRGQLEALTRQVEMLTGSVCDRSALLTGGSQSSNSTGHQSPPSAAPSVAALTGSASGSASSPTTTRFSSRATFSVTSKTNSIERDEPIEVDPAPISQGLENGHLSSTENSIVPLRRNSPPNGVLHENSAPVPMAMPHLPITATTKVADSTVMKSPESPSSPMQATPSAITDSLTNSPPVTSDNQPQLESPVHAVSSVKTWAPTPARTMGSPRLTEKASSAPAKSVTYSGLFPHNTDRNVDTPGDLSFGRGIERRRELVRSQTLPRNIGAQARRSIFERLDSENNSRPKPVDSKPKLKRSQSFGVSSASSIKQILLEWCRSKTIGYQNIDIQNFSSSWSDGMAFCALVHSFFPTEFDYNGLSPAERKHNFELAFSTAEKKAGCDRLIEVEDMMVMGRKPDPMCVFTYVQSLYNHLRKFE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009790 (embryo development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030017 (sarcomere), GO:0031674 (I band), GO:0030018 (Z disc), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: Trehalose-phosphatase (EC 3.1.3.12) (Trehalose-6-phosphate phosphatase) (TPP) (A8NS89)
Organism: Brugia malayi (Filarial nematode worm)
Function: Catalyzes the hydrolysis of trehalose 6-phosphate to trehalose and phosphate; prevents the accumulation of toxic levels of trehalose 6-phosphate.
InterPro domains:
- IPR049063: Trehalose-6-phosphate phosphatase, C-terminal domain (domain) [210-477]
- IPR041064: Trehalose-6-phosphate phosphatase, helical bundle domain (domain) [64-159]
- IPR023214: HAD superfamily (homologous_superfamily) [210-483]
- IPR036412: HAD-like superfamily (homologous_superfamily) [208-450]
Sequence:
MTETVTDQGKQRSSKLQKNEAAKDEQVEGKGKETLESGTDKSAEQNSSLLVGQPDVIDNDNVQTVDDFKNLMYKMQETRRAIVFALLNEKDLTKDDVEILKRAYEKLTDNQTHSFQREMCTLTTKLSVNIGDETRGLEKDLKYLDALMNIRREEPNLLWPIIMSRVDLFSILANYHPKGKETFLKEYEDTVKFLKTFISSEAITGKKPIFITDWDGTMKDYCSQYATNLQPVYSAVGMTRFAASFTRISAVLTAGPLRGPGILDLTAMPIDGPVMFSGSWGREWWLSGKRVVHQDGITDEGFNALQRLDDEMKDLLHTSDYAPFALVGSGVQRKVDRLTLGVQTVCHHVTSELSNRYQMAVKERMHRVDPNSQILVFDPSTELEVEVVAHNSGIIWNKGNGVERLIKSLGDSLQSPGKILICGDTLSDIPMVRQAVKQNPDGVLAIFVGAKMSLREEVKQVIGDESRCCFVSCPDVIHAAMSQILNEHCIGK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0019203 (carbohydrate phosphatase activity), GO:0004805 (trehalose-phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006793 (phosphorus metabolic process), GO:0044249 (cellular biosynthetic process), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901575 (organic substance catabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0009311 (oligosaccharide metabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0005984 (disaccharide metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:0005991 (trehalose metabolic process), GO:0016311 (dephosphorylation), GO:0009312 (oligosaccharide biosynthetic process), GO:0046351 (disaccharide biosynthetic process), GO:0005992 (trehalose biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)