lokahq/bioreason-rl huggingface dataset:
Protein: Large ribosomal subunit protein eL30 (60S ribosomal protein L30) (Q6FXZ0)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Not known
InterPro domains:
- IPR039109: Large ribosomal subunit protein eL30-like (family) [5-104]
- IPR022991: Large ribosomal subunit protein eL30, conserved site (conserved_site) [20-96]
- IPR004038: Ribosomal protein eL8/eL30/eS12/Gadd45 (domain) [9-101]
- IPR029064: Ribosomal protein eL30-like superfamily (homologous_superfamily) [2-105]
Sequence:
MAPIKTQESINQKLALVVKSGKFTLGYKSTIKSLRQGKSKLIIIAANTPVLRKSELEYYAMLSKTKVYYFQGGNNELGTAVGKLFRVGVVSVLDAGDSDILTALA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0051701 (biological process involved in interaction with host), GO:0044406 (adhesion of symbiont to host)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: Vitronectin (VN) (S-protein) (Serum-spreading factor) (P29788)
Organism: Mus musculus (Mouse)
Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Subcellular location: Secreted, extracellular space.
InterPro domains:
- IPR000585: Hemopexin-like domain (domain) [153-473]
- IPR018486: Hemopexin, conserved site (conserved_site) [195-349]
- IPR020436: Somatomedin B domain, chordata (domain) [19-59]
- IPR036024: Somatomedin B-like domain superfamily (homologous_superfamily) [21-67]
- IPR051298: Heme transport and cell adhesion protein (family) [119-474]
- IPR018487: Hemopexin-like repeats (repeat) [157-473]
- IPR001212: Somatomedin B domain (domain) [20-63]
- IPR036375: Hemopexin-like domain superfamily (homologous_superfamily) [144-477]
Sequence:
MAPLRPFFILALVAWVSLADQESCKGRCTQGFMASKKCQCDELCTYYQSCCADYMEQCKPQVTRGDVFTMPEDDYWSYDYVEEPKNNTNTGVQPENTSPPGDLNPRTDGTLKPTAFLDPEEQPSTPAPKVEQQEEILRPDTTDQGTPEFPEEELCSGKPFDAFTDLKNGSLFAFRGQYCYELDETAVRPGYPKLIQDVWGIEGPIDAAFTRINCQGKTYLFKGSQYWRFEDGVLDPGYPRNISEGFSGIPDNVDAAFALPAHRYSGRERVYFFKGKQYWEYEFQQQPSQEECEGSSLSAVFEHFALLQRDSWENIFELLFWGRSSDGAREPQFISRNWHGVPGKVDAAMAGRIYVTGSLSHSAQAKKQKSKRRSRKRYRSRRGRGHRRSQSSNSRRSSRSIWFSLFSSEESGLGTYNNYDYDMDWLVPATCEPIQSVYFFSGDKYYRVNLRTRRVDSVNPPYPRSIAQYWLGCPTSEK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:1901681 (sulfur compound binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding), GO:0008201 (heparin binding), GO:0005178 (integrin binding), GO:0005102 (signaling receptor binding), GO:0005539 (glycosaminoglycan binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0031099 (regeneration), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0031100 (animal organ regeneration), GO:0043933 (protein-containing complex organization), GO:0061008 (hepaticobiliary system development), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0097421 (liver regeneration), GO:0001889 (liver development), GO:0051258 (protein polymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix)
Protein: Histamine H1 receptor (Q195J2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
InterPro domains:
- IPR000921: Histamine H1 receptor (family) [179-530]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [68-515]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [53-523]
Sequence:
MCFLTTLTSCDTLERPMESTTTLTTANSQFKRIDNTTLLIPSAPLHHHINNAVLGIFLGMLSLLTVIMNLLVLFAVRKERTLHTVGNLYIVSLSIADLIVGATVMPLNLVYLLEDQWKLGHVVCQFWLVMDYVASTASIFSLFILCLDRYRSVRHPLQYLKYRTRGRATLLICSAWLLSMTWTIPILGWRMFASVDKKTELENQCDTDFRFVTWFKVLTAILNFYIPSFLMLVFYSQIFIAVRDHYREWENFAGPALKTDATDTLTNGLQLQITKASEKESLALNAYSQNEGLLDQYSLEQPYNSRENTEEMTSEPKRKMCYKKKAIFNLSKRMRKSVPDSEISFQSDDGETVAEGRPSLSLAFLQSENTAQPQTFINVSDCNVLVPNSVGNICESAPTVDIHNYTAVLCTPPSPPSPWAENSPPLDASIALPAKQSWQKLCEQSKQSIHSMRIRKERKAARQLGFIIGVFMVCWIPYFITFMVMALCETCVHHDLHMFTIWLGYINSTLNPFIYPLCNENFKRVFKKIFHMSR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008227 (G protein-coupled amine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0021517 (ventral spinal cord development), GO:0021510 (spinal cord development), GO:0022008 (neurogenesis), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0021515 (cell differentiation in spinal cord), GO:0030182 (neuron differentiation), GO:0021522 (spinal cord motor neuron differentiation), GO:0021953 (central nervous system neuron differentiation), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: FHA domain-containing protein (Q3UUI2)
Organism: Mus musculus (Mouse)
Function: Not known
InterPro domains:
- IPR000253: Forkhead-associated (FHA) domain (domain) [128-206]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [75-218]
- IPR050923: Cellular Process Regulator and RNA Processing Protein (family) [66-507]
Sequence:
ELDAPAPQEVSSEFKKPVLPVPSAVRGKAPASSPSVSEDVKKECLAAQLDSGCEEPEVPPPQPDSQETGGPPVEQLRSPRVAPASGGPTRAPPYREPSWGSPATAPYSLETLKGGTILGTRTLKDTSCCFFGRLASCDICLEHPSVSRYHAVLQHRGADPSGDSEGHEQGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVMRFGGSTRLFILQGPEEDREAESELTVTQLKELRKQQQILLEKKMLGEDSDEEEEANTTEGKSSRSGQDDELGCTWGMGEDAVEDEAEENPIALDFQQDREAFYIKDPKKALQGFFDREGEELEYEFDEQGHSTWLCRVRLPVDDSTGKQLVAEAIHSGKKKEAMVQCSLEACRVLDTLGLLRQEAVSRKRKAKNWEDEDFYDSDDDTFLDRTGLVEKKRLNRMKKAEKLDEKPETFESLVAKLNDAERELAEISERLKASSKVLSEPSSQDSLDAFMSEMKSGSTLDGVSRKKLHLRTFELRKEQQRLKGLIKLVKPAEIPELKKTELQTTNA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0050793 (regulation of developmental process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0040008 (regulation of growth), GO:0050794 (regulation of cellular process), GO:0016043 (cellular component organization), GO:2000026 (regulation of multicellular organismal development), GO:0044085 (cellular component biogenesis), GO:0051128 (regulation of cellular component organization), GO:0048638 (regulation of developmental growth), GO:0001558 (regulation of cell growth), GO:0061387 (regulation of extent of cell growth), GO:0030516 (regulation of axon extension), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0060284 (regulation of cell development), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0050767 (regulation of neurogenesis), GO:0051276 (chromosome organization), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: AT5g22310/MWD9_9 (Trichohyalin-like protein) (Q93ZM2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
InterPro domains:
- IPR043424: Protein BRANCHLESS TRICHOME-like (family) [26-447]
Sequence:
MEQRKKGCKIRKRGGSSSSSSSLARRNRFKRAIFAGKRAAQDDGGSGTPVKSITAAKTPVLLSFSPENLPIDHHQLQKSCVSARKLAATLWEINDDADPPVNSDKDCLRSKKPSRYRAKKSTEFSSIDFPPRSSDPISRLSSERIDLCDDMIRRRSTNPQKLNPIEYKIIGANSVKTRFKNVSDGLTTSKELVKVLKRIGELGDDHKTASNRLISALLCELDRARSSLKHLMSELDEEEEEKRRLIESLQEEAMVERKLRRRTEKMNRRLGRELTEAKETERKMKEEMKREKRAKDVLEEVCDELTKGIGDDKKEMEKEREMMHIADVLREERVQMKLTEAKFEFEDKYAAVERLKKELRRVLDGEEGKGSSEIRRILEVIDGSGSDDDEESDLKSIELNMESGSKWGYVDSLKDRRRFDGSGGDDDDDDPVEKRSVIVENGERDESLKTLRDYIVSNVRCIGPSSSEQWNHRNLPSSEFV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0051640 (organelle localization), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0051656 (establishment of organelle localization), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0031109 (microtubule polymerization or depolymerization), GO:0043933 (protein-containing complex organization), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0007010 (cytoskeleton organization), GO:0065003 (protein-containing complex assembly), GO:0043622 (cortical microtubule organization), GO:0046785 (microtubule polymerization), GO:0051258 (protein polymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Cytochrome bo(3) ubiquinol oxidase subunit 2 (Cytochrome b562-o complex subunit II) (Cytochrome o ubiquinol oxidase subunit 2) (Cytochrome o subunit 2) (Oxidase bo(3) subunit 2) (Ubiquinol oxidase chain B) (Ubiquinol oxidase polypeptide II) (Ubiquinol oxidase subunit 2) (P0ABJ1)
Organism: Escherichia coli (strain K12)
Function: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:6365921}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:6365921}.
InterPro domains:
- IPR011759: Cytochrome C oxidase subunit II, transmembrane domain (domain) [21-118]
- IPR008972: Cupredoxin (homologous_superfamily) [113-282]
- IPR045187: Cytochrome c/quinol oxidase subunit II (family) [23-242]
- IPR036257: Cytochrome C oxidase subunit II, transmembrane domain superfamily (homologous_superfamily) [27-116]
- IPR002429: Cytochrome c oxidase subunit II-like C-terminal (domain) [124-237]
- IPR006333: Cytochrome o ubiquinol oxidase subunit II (family) [1-313]
- IPR034227: Ubiquinol oxidase subunit 2, cupredoxin domain (domain) [127-225]
- IPR010514: COX aromatic rich motif (domain) [239-285]
Sequence:
MRLRKYNKSLGWLSLFAGTVLLSGCNSALLDPKGQIGLEQRSLILTAFGLMLIVVIPAILMAVGFAWKYRASNKDAKYSPNWSHSNKVEAVVWTVPILIIIFLAVLTWKTTHALEPSKPLAHDEKPITIEVVSMDWKWFFIYPEQGIATVNEIAFPANTPVYFKVTSNSVMNSFFIPRLGSQIYAMAGMQTRLHLIANEPGTYDGISASYSGPGFSGMKFKAIATPDRAAFDQWVAKAKQSPNTMSDMAAFEKLAAPSEYNQVEYFSNVKPDLFADVINKFMAHGKSMDMTQPEGEHSAHEGMEGMDMSHAESAH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0022900 (electron transport chain), GO:0022904 (respiratory electron transport chain), GO:0045333 (cellular respiration), GO:0009060 (aerobic respiration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0016020 (membrane), GO:1902494 (catalytic complex), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:1990204 (oxidoreductase complex), GO:0005886 (plasma membrane)
Protein: MICOS complex subunit MIC60 (Mitofilin) (H7C463)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU363000}; Single-pass membrane protein {ECO:0000256|RuleBase:RU363000}.
InterPro domains:
- IPR019133: MICOS complex subunit MIC60 (family) [3-608]
Sequence:
XIQSGPLKISSVSEVMKESKQPASQLQKQKGDTPASATAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALSALAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0009653 (anatomical structure morphogenesis), GO:0032989 (cellular component morphogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0032990 (cell part morphogenesis), GO:0007005 (mitochondrion organization), GO:0070584 (mitochondrion morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Universal minicircle sequence binding protein (UMSBP), putative (Q38B00)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
InterPro domains:
- IPR051714: CCHC-type Zinc Finger Nucleic Acid Binding (family) [13-63]
- IPR001878: Zinc finger, CCHC-type (domain) [18-212]
- IPR036875: Zinc finger, CCHC-type superfamily (homologous_superfamily) [12-212]
Sequence:
MADEASTAKRHRAEGGNNCHRCGQPGHFARECPNVPPGAMGDRACYTCGQPDHLSRDCPSNRGPAPMGGGRACYNCGQPGHFSRECPNMRGGPMGGAPMGGGRACYNCGQPGHFSRECPNMRGGPMGGAPMGGGRACYNCGQPGHFSRECPNMRGGNMGGGRACYHCQQEGHIARECPNAPADAAAGGAAAGGGRACYNCGQPGHLSRACPVK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007049 (cell cycle), GO:0000278 (mitotic cell cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Heat shock protein hsp9 (P50519)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
InterPro domains:
- IPR007250: Heat shock protein 9/12 (family) [1-67]
Sequence:
MSDPARKSFTEQGKEKMTPDSSKSTLDKAKESITGAYDKVASAFTSDEDKSTSQEAHDKAQRFVDDKL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044183 (protein folding chaperone), GO:0008289 (lipid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0001666 (response to hypoxia), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0071456 (cellular response to hypoxia), GO:0071453 (cellular response to oxygen levels), GO:0036293 (response to decreased oxygen levels), GO:0036294 (cellular response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Baccharis oxide synthase (StrBOS) (EC 5.4.99.51) (B9X0J1)
Organism: Stevia rebaudiana (Stevia) (Eupatorium rebaudianum)
Function: Oxidosqualene cyclase converting (3S)-2,3-epoxy-2,3-dihydrosqualene to baccharis oxide, a triterpene with a 3,10-oxide bridge in the A-ring. Also mediates conversion of other triterpenoids at a much lower level.
InterPro domains:
- IPR008930: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (homologous_superfamily) [121-755]
- IPR032697: Squalene cyclase, N-terminal (domain) [99-402]
- IPR032696: Squalene cyclase, C-terminal (domain) [414-752]
- IPR018333: Squalene cyclase (family) [1-755]
- IPR002365: Terpene synthase, conserved site (conserved_site) [604-618]
Sequence:
MWRLKIADGNNNPYLYSTNNFVGRQTWEFDPNYGTQEERDEVEQARQHFWNNRHQFKATGDVLWRMQFIREKRFKQTIPQVKIEDGEEISYDKVTATLRRSVHLLAALQADDGHWPAENTGPMFFIQPLVICLYITGHLDRVFPKEHKKEILRYLYTQQNEDGGWGLHIEGQSIMFGTIMSYVCMRLLGEGPDGGLNGACTKARKWILDHGSVLASPSWGKIYLTILGVHEWEGCNPLPPEFWILPSIFPMHPAKMWCYCRLIYMPMSYLYGRRFVGPITPLVLQLREELYSQSYNDIKWKSTRHLVVKEDLHYPHPWLQDLMWDGLYIFTEPLLTRWPFSKLREKALKTTINHIHYEDENSRYITIGAVEKSLCMLACWDEDPDGVCFKKHLARIPDYIWVSEDGLKMQSFGSQLWDASLAIQALLATDLNHDIEPILRKGHDFIKASQVKDNPSGDFKSMYRHITKGSWTFSDQDHGWQTSDCTTEGLKCCLLLSKMSAEIVGEKMQPEQFYDAVNLILSLQCKNGGEAGWEPAGESNWLEFLNPSELFEDIVLEHDSVECTATGMQALVIFKKLYPKHRREEIEKFLKDACGYLEKVQMQDGSWYGEWGICFTYGTCFALGGMEAIGKTYENCEAIRRAVNFLLTTQRNDGGWGESYRSSPKKKYVPLEGNRSNLVQTACALMGLIRSKQEERDPTPLHRAAKLLINSQMENGDFPQEETGGVFKKNCLLHYPMYRNIYTLWALGEYRKKVLPQPTKV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016866 (intramolecular transferase activity), GO:0031559 (oxidosqualene cyclase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0006720 (isoprenoid metabolic process), GO:0008299 (isoprenoid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006721 (terpenoid metabolic process), GO:0016114 (terpenoid biosynthetic process), GO:0006722 (triterpenoid metabolic process), GO:0016104 (triterpenoid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005811 (lipid droplet)