Protein: Coiled-coil domain-containing protein 66 (A2RUB6)
Organism: Homo sapiens (Human)
Function: Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites. Plays a role in retina morphogenesis and/or homeostasis (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:35849559, ECO:0000269|PubMed:36606424}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:35849559, ECO:0000269|PubMed:36606424}. Cell projection, cilium {ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:36606424}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:36606424}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36606424}. Photoreceptor inner segment {ECO:0000269|PubMed:19777273}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:19777273}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:35849559}. Midbody {ECO:0000269|PubMed:35849559}. Note=Restricted to the centrosomes and the spindle microtubules during mitosis (PubMed:28235840). Enriched in the inner segment of the photoreceptor (PubMed:19777273). {ECO:0000269|PubMed:19777273, ECO:0000269|PubMed:28235840}.
InterPro domains:
- IPR040467: CCDC66 domain (domain) [412-563]
- IPR039183: Coiled-coil domain-containing protein 66 (family) [35-947]
Sequence:
MNLGDGLKLETELLDGKTKLILSPYEHKSKISVKMGNKAKIAKCPLRTKTGHILKSTQDTCIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKDLCKQCIDKDCLHIQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNRGISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLHLPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNEIYYLDPDAPLSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLLQKQKELESSLLPLAENQEESFGSSF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0051606 (detection of stimulus), GO:0003008 (system process), GO:0009581 (detection of external stimulus), GO:0009582 (detection of abiotic stimulus), GO:0050877 (nervous system process), GO:0050906 (detection of stimulus involved in sensory perception), GO:0009314 (response to radiation), GO:0050962 (detection of light stimulus involved in sensory perception), GO:0009416 (response to light stimulus), GO:0009583 (detection of light stimulus), GO:0007600 (sensory perception), GO:0050953 (sensory perception of light stimulus), GO:0050908 (detection of light stimulus involved in visual perception), GO:0009584 (detection of visible light), GO:0007601 (visual perception)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0090543 (Flemming body), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030496 (midbody), GO:0034451 (centriolar satellite), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)