lokahq/bioreason-rl huggingface dataset:
Protein: Probable periplasmic serine endoprotease DegP-like (EC 3.4.21.107) (Protease Do) (Q57155)
Organism: Pseudomonas aeruginosa
Function: Not known
Subcellular location: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
InterPro domains:
- IPR036034: PDZ superfamily (homologous_superfamily) [252-474]
- IPR001940: Peptidase S1C (family) [107-322]
- IPR011782: Peptidase S1C, Do (family) [28-470]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [6-279]
- IPR001478: PDZ domain (domain) [261-468]
Sequence:
MHTLKRCMAAMVALLALSLAMTARAELPDFTPLVEQASPAVVNISTRQKLPDRAMARGQLSIPDLEGLPPMFRDFLERSIPQVPRNPRGQQREAQSLGSGFIISNDGYILTNNHVVADADEILVRLSDRSEHKAKLIGADPRSDVAVLKIEAKNLPTLKLGDSNKLKVGEWVLAIGSPFGFDHSVTAGIVSAKGRSLPNESYVPFIQTDVAINPGNSGGPLLNLQGEVVGINSQIFTRSGGFMGLSFAIPIDVALNVADQLKKAGKVSRGWLGVVIQEVNKDLAESFGLDKPSGALVAQLVEDGPAAKGGLQVGDVILSLNGQSINESADLPHLVGNMKPGDKINLDVIRNGQRKSLSMAVGSLPDDDEEIASMGAPGAERSSNRLGVTVADLTAEQRKSLDIQGGVVIKEVQDGPAAVIGLRPGDVITHLDNKAVTSTKVFADVAKALPKNRSVSMRVLRQGRASFITFKLAE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042597 (periplasmic space)
Protein: Elongation factor family protein (F4K409)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
InterPro domains:
- IPR047043: GTP-binding protein BipA, domain 3 (domain) [383-461]
- IPR031157: Tr-type G domain, conserved site (conserved_site) [122-137]
- IPR047042: GTP-binding protein BipA, domain 2 (domain) [283-376]
- IPR004161: Translation elongation factor EFTu-like, domain 2 (domain) [297-367]
- IPR042116: GTP-binding protein TypA/BipA, C-terminal (homologous_superfamily) [561-668]
- IPR006298: GTP-binding protein BipA (family) [83-675]
- IPR035647: EF-G domain III/V-like (homologous_superfamily) [381-590]
- IPR000795: Translational (tr)-type GTP-binding domain (domain) [81-276]
- IPR005225: Small GTP-binding domain (domain) [84-233]
- IPR048876: TypA/BipA, C-terminal domain (domain) [564-668]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [72-283]
- IPR009000: Translation protein, beta-barrel domain superfamily (homologous_superfamily) [229-376]
- IPR047041: GTP-binding protein BipA, GTP-binding domain (domain) [82-275]
- IPR000640: Elongation factor EFG, domain V-like (domain) [473-562]
- IPR035651: BipA, domain V (domain) [476-555]
Sequence:
MELSLSTSSASPAVLRRQASPLLHKQQVLGVSFASALKPGGGALRFPSRRPLPRPITCSASPSTAEPASVEVKKKQLDRRDNVRNIAIVAHVDHGKTTLVDSMLRQAKVFRDNQVMQERIMDSNDLERERGITILSKNTSITYKNTKVNIIDTPGHSDFGGEVERVLNMVDGVLLVVDSVEGPMPQTRFVLKKALEFGHAVVVVVNKIDRPSARPEFVVNSTFELFIELNATDEQCDFQAIYASGIKGKAGLSPDDLAEDLGPLFEAIIRCVPGPNIEKDGALQMLATNIEYDEHKGRIAIGRLHAGVLRKGMDVRVCTSEDSCRFARVSELFVYEKFYRVPTDSVEAGDICAVCGIDNIQIGETIADKVHGKPLPTIKVEEPTVKMSFSVNTSPFSGREGKYVTSRNLRDRLNRELERNLAMKVEDGETADTFIVSGRGTLHITILIENMRREGYEFMVGPPKVINKRVNDKLLEPYEIATVEVPEAHMGPVVELLGKRRGQMFDMQGVGSEGTTFLRYKIPTRGLLGLRNAILTASRGTAILNTVFDSYGPWAGDISTRDLGSLVAFEDGTSTSYALASAQERGQMFVGSGVDVYKGQIVGIHQRPGDLGLNICKKKAATNIRSNKDVTVILDTPLTYSLDDCIEYIEEDELVEVTPSSIRMCKNQKMAKKGRQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005507 (copper ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006810 (transport), GO:0006996 (organelle organization), GO:0009657 (plastid organization), GO:0009658 (chloroplast organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Alpha-galactosidase 1 (AtAGAL1) (EC 3.2.1.22) (Alpha-D-galactoside galactohydrolase 1) (Melibiase 1) (Q9FT97)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May regulate leaf (and possibly other organ) development by functioning in cell wall loosening and cell wall expansion.
Subcellular location: Secreted, cell wall {ECO:0000250|UniProtKB:Q8RX86}. Secreted, extracellular space, apoplast {ECO:0000250|UniProtKB:Q8RX86}.
InterPro domains:
- IPR000111: Glycoside hydrolase family 27/36, conserved site (conserved_site) [89-105]
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [47-318]
- IPR002241: Glycoside hydrolase, family 27 (family) [14-408]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [46-319]
- IPR041233: Alpha galactosidase, C-terminal domain (domain) [329-406]
- IPR013780: Glycosyl hydrolase, all-beta (homologous_superfamily) [320-409]
Sequence:
MSRRAMVIKMPILMILISSMVMTMVESSRSVNNGHDDSEILRRHLLTNGLGVTPPMGWNSWNHFSCNIDEKMIKETADALVTTGLSKLGYNYVNIDDCWAEISRDSKGSLVPKKSTFPSGIKAVADYVHSKGLKLGIYSDAGYFTCSKTMPGSLGYEEHDAKTFAEWGIDYLKYDNCNSDGSKPTVRYPVMTRALMKSGRPIFHSLCEWGDMHPALWGSPVGNSWRTTNDIKDTWLSMISIADMNEVYAEHARPGGWNDPDMLEVGNGGMTKDEYIVHFSIWAISKAPLLLGCDIRNMTKETMEIVANKEVIAINQDPHGVQAKKVRMEGDLEVWAGPLSGYRVALLLLNRGPSRTSITALWEDIEIPANSIVEARDLWEHQTLKQKFVGNLTATVDSHACKLYVLKPVA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015925 (galactosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0016052 (carbohydrate catabolic process), GO:0009057 (macromolecule catabolic process), GO:0005976 (polysaccharide metabolic process), GO:0000272 (polysaccharide catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0048046 (apoplast), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005618 (cell wall), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0009505 (plant-type cell wall), GO:0097708 (intracellular vesicle)
Protein: Cyclin-B2-3 (G2/mitotic-specific cyclin-B2-3) (CycB2;3) (Q9LDM4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
InterPro domains:
- IPR048258: Cyclins, cyclin-box (conserved_site) [210-241]
- IPR004367: Cyclin, C-terminal domain (domain) [308-425]
- IPR013763: Cyclin-like domain (domain) [215-394]
- IPR039361: Cyclin (family) [144-411]
- IPR006671: Cyclin, N-terminal (domain) [180-305]
- IPR036915: Cyclin-like superfamily (homologous_superfamily) [169-425]
- IPR046965: Cyclin A/B-like (family) [14-429]
Sequence:
MVRSDENSLGLIGSMSLQGGGVVGKIKTTATTGPTRRALSTINKNITEAPSYPYAVNKRSVSERDGICNKPPVHRPVTRKFAAQLADHKPHIRDEETKKPDSVSSEEPETIIIDVDESDKEGGDSNEPMFVQHTEAMLEEIEQMEKEIEMEDADKEEEPVIDIDACDKNNPLAAVEYIHDMHTFYKNFEKLSCVPPNYMDNQQDLNERMRGILIDWLIEVHYKFELMEETLYLTINVIDRFLAVHQIVRKKLQLVGVTALLLACKYEEVSVPVVDDLILISDKAYSRREVLDMEKLMANTLQFNFSLPTPYVFMKRFLKAAQSDKKLEILSFFMIELCLVEYEMLEYLPSKLAASAIYTAQCTLKGFEEWSKTCEFHTGYNEKQLLACARKMVAFHHKAGTGKLTGVHRKYNTSKFCHAARTEPAGFLI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0060255 (regulation of macromolecule metabolic process), GO:0050790 (regulation of catalytic activity), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051338 (regulation of transferase activity), GO:1904029 (regulation of cyclin-dependent protein kinase activity), GO:0051246 (regulation of protein metabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity), GO:0043549 (regulation of kinase activity), GO:0031399 (regulation of protein modification process), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0071900 (regulation of protein serine/threonine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (Q59LL5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
InterPro domains:
- IPR020568: Ribosomal protein uS5 domain 2-type superfamily (homologous_superfamily) [3-206]
- IPR038494: Imidazole glycerol phosphate dehydratase domain superfamily (homologous_superfamily) [1-222]
- IPR020565: Imidazoleglycerol-phosphate dehydratase, conserved site (conserved_site) [89-196]
- IPR000807: Imidazoleglycerol-phosphate dehydratase (family) [2-222]
Sequence:
MSREALINRITNETKIQIALNLDGGKLELKESIFPNQSIIIDEHHAKQVSGSQYINVQTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTAEDVGISLGMAFKQALGQIKGVKRFGHGFAPLDEALSRAVVDLSNRPFAVIELGLKREKIGDLSTEMIPHVLESFAGAAGITIHVDCLRGFNDHHRAESAFKALAIAIKEAISKTGKNDIPSTKGVLS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016836 (hydro-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0006547 (histidine metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0000105 (histidine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: Opacity protein opA68 (opA27.5) (Q04881)
Organism: Neisseria gonorrhoeae
Function: Implicated in a number of adherence functions. OPA proteins are implicated in pathogenesis and are subject to phase variation.
Subcellular location: Cell outer membrane.
InterPro domains:
- IPR011250: Outer membrane protein/outer membrane enzyme PagP, beta-barrel (homologous_superfamily) [8-238]
- IPR003394: Porin, opacity type (domain) [58-238]
Sequence:
AGEGNGRGPYVQADLAYAYEHITHDYPKPTDPSKGKLSTVSDYFRNIRTHSIHPRVSVGYDFGGWRIAADYARYRKWNDSKYSVSIKNLQRRTSNGNRRDRKTENQENGSFHAVSSLGLSAVYDFKLNDKFKPYIGARVAYGHVRHSIDSTKKITQFLTTAGARGTVSTVHPPYKSTQDAHHQSDSIRRVGLGVIAGVGFGITPKLTLDAGYRYHNWGRLENTRFKTHEASLGVRYRF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0051701 (biological process involved in interaction with host), GO:0044406 (adhesion of symbiont to host), GO:0044650 (adhesion of symbiont to host cell)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0009279 (cell outer membrane), GO:0019867 (outer membrane), GO:0030313 (cell envelope)
Protein: Wdr36 protein (Q6NSU4)
Organism: Mus musculus (Mouse)
Function: Not known
InterPro domains:
- IPR001680: WD40 repeat (repeat) [7-36]
- IPR019775: WD40 repeat, conserved site (conserved_site) [19-33]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [4-75]
- IPR007319: Small-subunit processome, Utp21 (domain) [127-329]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [4-99]
Sequence:
PRVRGQINDMTFSPDGRWLISAAMDCSVRTWDLPSGCLIDCFLLDSAPLNVTMSPTGDFLATSHVDHLGIYLWSNISLYSVVSLRPLPPDYVPSIVMLPGTCQTQGMEDLEEKTEPSDEMIEYESPEQLSEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPQSAPFFIPTVPGLVPRFAVPEPSSDPQQSKVVNLGILAQKSNFYLKLEEGLLNNQYEAALNLLKELGPSGIETELRNLSPDDGGSVEVMRSFLSMIGMMLDRKRDFELAQAYLALFLKLHLRTLPSEPALLEELVKLSSQVEKDWTHLQSLFNQSMCVLNYIKSAFL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0050793 (regulation of developmental process), GO:0071840 (cellular component organization or biogenesis), GO:0065008 (regulation of biological quality), GO:0048871 (multicellular organismal-level homeostasis), GO:0040008 (regulation of growth), GO:0050794 (regulation of cellular process), GO:0016043 (cellular component organization), GO:0001894 (tissue homeostasis), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0060249 (anatomical structure homeostasis), GO:0048638 (regulation of developmental growth), GO:0001558 (regulation of cell growth), GO:0061387 (regulation of extent of cell growth), GO:0030516 (regulation of axon extension), GO:0032535 (regulation of cellular component size), GO:0001895 (retina homeostasis), GO:0008361 (regulation of cell size)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Solute carrier family 7 (cationic amino acid transporter, y+ system), member 15 (Q8BZV2)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
InterPro domains:
- IPR002293: Amino acid/polyamine transporter I (family) [3-179]
- IPR050598: Cellular Amino Acid Transporter (family) [1-227]
Sequence:
MTAVPLVTILYVLVNISYLLVMSPSEILSSDAIAVIWGDRVLGSWAWLVPLAVALSTFGTVNGGFFSGSRVCYAAAREGHMPQLMSMIHVNRLTPAPAQIFTTAVALLLVIPGNFSTFVNLLSFLSWLTYGTTFACLLYLRIKTKNLPHTYKVPTFIPAIMLLVSLYLVLAPIIDHPQIEFLYIFLFVLSGFPVYFLLFHFQCQFKCIQTATMHLQLLLEVAPTTKDH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0006865 (amino acid transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) (Q7KUB0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
InterPro domains:
- IPR019818: Isocitrate/isopropylmalate dehydrogenase, conserved site (conserved_site) [269-288]
- IPR024084: Isopropylmalate dehydrogenase-like domain (domain) [9-400]
- IPR004790: Isocitrate dehydrogenase NADP-dependent (family) [1-411]
Sequence:
MAQKIKAGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWKGTDGQVIDEVINDFKGPGIALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLEGALAKNAVAAK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004448 (isocitrate dehydrogenase [NAD(P)+] activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006066 (alcohol metabolic process), GO:0006082 (organic acid metabolic process), GO:1902652 (secondary alcohol metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0006102 (isocitrate metabolic process), GO:0072350 (tricarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Lamin (Q90XD7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus lamina {ECO:0000256|ARBA:ARBA00024186}. Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
InterPro domains:
- IPR001322: Lamin tail domain (domain) [446-563]
- IPR018039: Intermediate filament protein, conserved site (conserved_site) [370-378]
- IPR036415: Lamin tail domain superfamily (homologous_superfamily) [409-566]
- IPR039008: Intermediate filament, rod domain (domain) [27-384]
Sequence:
METPGQKRSSRGGVTNVLSPTRISRLQEKEDLSNLNDRLAVYIDKVRSLEVENAGLRMRITESETEISRELSGMKAAYEAELADARKTLDSVAKERARLQLELSKVREDYKELKARNGKKEADLESALARLKDLESLLNSKDASLSTALGEKRTLEVEVRDLKAQLAKLEGSLNDAKKQLQDEMLRRVDAENRIQTLKEELEFQKNIYSEELRESKRRYESRVVEIDSGRQQDYESKLADALTDLRNQHEEQLRIYKEEIEKTYNSKLENARSSAERNSHLVGAAHEELQQTRVRMEGVSSQLSQLQKQLAAREAKIRELEEALSRERDILRRRLEDKEKEMAEMRQRMQQQLDEYQELLDIKLALDMEISAYRKLLEGEEERLRLSPSPPPARGVTVTRSSGSGSHTRVVQSSTSRTSSGSAKKRRLNDNDSDASSVVGGTVTRTRIFQQASASGRVTVDEVDLEGKFVRLNNKSDQDQSLGHWQVKRQIGSGTPIVYKFPPKFNLKAGQTVTIWAAGAGGTHSPPSDLVWKTQNSWGSGDLFQTTLISSSGEEMAMRKVTRTLFQDEEDDEMAAHSTCGDSEYNLRSRTVLCGSCGQPSDRNSSCVSASSGVSSASRSFSSGGGGGLTEAFVSPSHFIVSNDKPRQAGPKVDNCSIM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005200 (structural constituent of cytoskeleton)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0003013 (circulatory system process), GO:0008015 (blood circulation), GO:0003015 (heart process), GO:0060047 (heart contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Partner of bursicon (Bursicon subunit beta) (Q9VJS7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading. Heterodimer specifically activates the G protein-coupled receptor rk.
Subcellular location: Secreted {ECO:0000269|PubMed:15703293}.
InterPro domains:
- IPR034441: Bursicon subunit beta (family) [7-141]
- IPR029034: Cystine-knot cytokine (homologous_superfamily) [22-139]
Sequence:
MHVQELLFVAAILVPQCLRALRYSQGTGDENCETLKSEIHLIKEEFDELGRMQRTCNADVIVNKCEGLCNSQVQPSVITPTGFLKECYCCRESFLKEKVITLTHCYDPDGTRLTSPEMGSMDIRLREPTECKCFKCGDFTR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005179 (hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)