lokahq/bioreason-rl huggingface dataset:
Protein: FIG4 phosphoinositide 5-phosphatase (A0A8I6ADY9)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
InterPro domains:
- IPR002013: SAC domain (domain) [93-527]
- IPR043573: Polyphosphoinositide phosphatase Fig4-like (family) [11-780]
Sequence:
MPTAAAPIISSVQKLVLYETRARYFLVGSNHAETKFRVLKIDRTEPKDLVVIDDRHVYTQQEVRELLGRLDLGNRTKLSQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKIEDTSMIYIPNDSVRITHPDEARYVYSYDLSHSLQYNLTVLRMPLEMLKSETSKTCQESFDIFEDEGLTTQGGSGVFGISSEPYMKYVWNGELLDIIKNSVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSRFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVPLFWSQDISTMMPKPPITLDQADPFAHIAALHFDQMLQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHSIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSVLRPDEKGISLWSEVAQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKNTMSLLPPKRSYTHWWTPEVVKHLPLPYDEVICAANLKKLTVKKFHRWEEEIDIHNEFFRPYELSSFDDTFCLAMTSSARDFMPKTIGIDPSPFTVRKPDETGKSVLGNKSNREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREDEGSISQRSTPVKMTDTGDSAKVTESVAQPMKEVYGVSLSRSLSEEDHSIYARFVQLGQSQHRQDWSSPQMCARCSDGVIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDTAIYREYIRNRYL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0052866 (phosphatidylinositol phosphate phosphatase activity), GO:0034593 (phosphatidylinositol bisphosphate phosphatase activity), GO:0034595 (phosphatidylinositol phosphate 5-phosphatase activity), GO:0106018 (phosphatidylinositol-3,5-bisphosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0033043 (regulation of organelle organization), GO:0044088 (regulation of vacuole organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0044232 (organelle membrane contact site), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0045202 (synapse), GO:0030133 (transport vesicle), GO:0043227 (membrane-bounded organelle), GO:0030658 (transport vesicle membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0005770 (late endosome), GO:0005769 (early endosome), GO:0030672 (synaptic vesicle membrane), GO:0010008 (endosome membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0031901 (early endosome membrane), GO:0031902 (late endosome membrane)
Protein: Palmitoyltransferase (EC 2.3.1.225) (Q9VQK9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004166}.
InterPro domains:
- IPR001594: Palmitoyltransferase, DHHC domain (domain) [263-400]
- IPR039859: Palmitoyltransferase PFA4/ZDHHC16/ZDHHC20/ERF2-like (family) [150-415]
Sequence:
MFLMTAGTSNFLSAAWRSEAEESKSKENGSLCCCEYVAEDSRERSHILGCCCNCVDFDLVCTRLVTCRAIDRRNIDGMLIAFQDRLRLPWRGGAKRISPAAVAPAFIVPLMLGLATLNSKTAIVLMLTLVGFTIWGMELAKRTATRTNFFLSWLVFSVFYMIIIFEFQVPLLELAPEENYALMFFSCAALYCLYSAKALSPLNLVSAQYGTTPKDELPGIAEASSGEEQAEAQTTLQMESVLSLDDDEVGDMDTAERSGLMHGQPNICEICRKVTPRRAYHCPVCGTCVKRRDHHSYWLNCCIGERNYVWYIVGLALSEIALLLGANLTLTSICHPFMVVRPLGYPVLLPDDCSEVFEGFDLGISFVVACYALLISSYIAFILARQAYLWWKGSTLHEYKRTSNAAGRNRIWSNWRAILK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016409 (palmitoyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0046907 (intracellular transport), GO:0051649 (establishment of localization in cell), GO:0006810 (transport), GO:0006888 (endoplasmic reticulum to Golgi vesicle-mediated transport), GO:0016192 (vesicle-mediated transport), GO:0048193 (Golgi vesicle transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Aquaporin 8b (Aquaporin-8) (C0HB60)
Organism: Salmo salar (Atlantic salmon)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
InterPro domains:
- IPR000425: Major intrinsic protein (family) [35-248]
- IPR034294: Aquaporin transporter (family) [29-249]
- IPR023277: Aquaporin 8 (family) [24-259]
- IPR023271: Aquaporin-like (homologous_superfamily) [9-255]
Sequence:
MTEGTMELGDVGTSLMASDSKKAPVKPPNKFERLVQPCLAELVGTMFFVFIGCVSVIENVEAAGRLQPALVHGLAVAVMVACMAEISGSHFNPPFTIAIYLCGGMKLNMVGPYLISQLIGGVLGASMSKLMTTTENYSKAQGAAFALLQSQDQLWGALFGEIAMTCLVTMVVLLGAVNAKSSSPMVPFMVGCTVIINILAGGDVSGTCLNPARALGPAIVANYWTYHWVYWVGPITGGLVAAALVRLLLGDRKTRILMK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0042887 (amide transmembrane transporter activity), GO:1901618 (organic hydroxy compound transmembrane transporter activity), GO:0015144 (carbohydrate transmembrane transporter activity), GO:0005372 (water transmembrane transporter activity), GO:0015166 (polyol transmembrane transporter activity), GO:0015168 (glycerol transmembrane transporter activity), GO:0015267 (channel activity), GO:0015204 (urea transmembrane transporter activity), GO:0015250 (water channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009628 (response to abiotic stimulus), GO:0006970 (response to osmotic stress), GO:0009651 (response to salt stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)
Protein: Fructose-1,6-bisphosphatase class 2 (FBPase class 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase class 2) (Q6M6E7)
Organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)
Function: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Is essential for growth on gluconeogenic carbon sources. Also displays a low activity toward glucose 6-phosphate, and fructose 6-phosphate, glycerol 3-phosphate, ribulose 1,5-bisphosphate and myo-inositol-monophosphate are not significant substrates.
Subcellular location: Cytoplasm {ECO:0000250}.
InterPro domains:
- IPR004464: Fructose-1,6-bisphosphatase class 2/Sedoheputulose-1,7-bisphosphatase (family) [9-329]
Sequence:
MNLKNPETPDRNLAMELVRVTEAAALASGRWVGRGMKNEGDGAAVDAMRQLINSVTMKGVVVIGEGEKDEAPMLYNGEEVGTGFGPEVDIAVDPVDGTTLMAEGRPNAISILAAAERGTMYDPSSVFYMKKIAVGPEAAGKIDIEAPVAHNINAVAKSKGINPSDVTVVVLDRPRHIELIADIRRAGAKVRLISDGDVAGAVAAAQDSNSVDIMMGTGGTPEGIITACAMKCMGGEIQGILAPMNDFERQKAHDAGLVLDQVLHTNDLVSSDNCYFVATGVTNGDMLRGVSYRANGATTRSLVMRAKSGTIRHIESVHQLSKLQEYSVVDYTTAT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0019203 (carbohydrate phosphatase activity), GO:0050308 (sugar-phosphatase activity), GO:0042132 (fructose 1,6-bisphosphate 1-phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0044262 (cellular carbohydrate metabolic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0019400 (alditol metabolic process), GO:0046165 (alcohol biosynthetic process), GO:0019751 (polyol metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:0046173 (polyol biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Mitochondrial dicarboxylate carrier (DIC) (Solute carrier family 25 member 10) (O89035)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane. Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes. Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:3355813}; Multi-pass membrane protein.
InterPro domains:
- IPR018108: Mitochondrial carrier protein, transmembrane region (repeat) [7-281]
- IPR023395: Mitochondrial carrier protein domain superfamily (homologous_superfamily) [7-283]
- IPR002067: Mitochondrial carrier protein (family) [81-286]
- IPR050391: Mitochondrial Metabolite Transporter (family) [6-277]
Sequence:
MAEARTSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALQVVRTDGFLALYNGLSASLCRQMTYSLTRFAIYETMRDYMTKDSQGPLPFYSKVLLGGISGLTGGFVGTPADLVNVRMQNDMKLPLSQRRNYSHALDGLYRVAREEGLKKLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFLSSFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETAKLGPQAFFKGLVPAGVRLVPHTVLTFMFLEQLRKHFGIKVAT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0005310 (dicarboxylic acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0006835 (dicarboxylic acid transport), GO:0015740 (C4-dicarboxylate transport), GO:0015744 (succinate transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) (PCA reductase) (P22008)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01925}.
InterPro domains:
- IPR008927: 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily (homologous_superfamily) [162-270]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [5-160]
- IPR028939: Pyrroline-5-carboxylate reductase, catalytic, N-terminal (domain) [5-99]
- IPR029036: Pyrroline-5-carboxylate reductase, dimerisation domain (domain) [163-267]
- IPR053790: Pyrroline-5-carboxylate reductase-like conserved site (conserved_site) [223-245]
- IPR000304: Pyrroline-5-carboxylate reductase-like (family) [3-270]
Sequence:
MSTPRIAFIGAGNMAASLIGGLRAQGVPAAQIRASDPGAEQRAKIAGEFAIDVVESNAEAVADADVVVLSVKPQAMKAVCQALAPALKPEQLIVSIAAGIPCASLEAWLGQPRPVVRCMPNTPALLRQGASGLYANAQVSAAQCEQAGQLLSAVGIALWLDDEAQIDAVTAVSGSGPAYFFLLMQAMTDAGEKLGLSRETASRLTLQTALGAAQMALSSEVEPAELRRRVTSPNGTTEAAIKSFQANGFEALVEQALNAASQRSAELAEQLGQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0042802 (identical protein binding), GO:0016645 (oxidoreductase activity, acting on the CH-NH group of donors), GO:0016646 (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0006560 (proline metabolic process), GO:0009084 (glutamine family amino acid biosynthetic process), GO:0006561 (proline biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Growth hormone secretagogue receptor type 1 (GH-releasing peptide receptor) (Ghrelin receptor) (C7G181)
Organism: Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
InterPro domains:
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [48-311]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [33-319]
- IPR003905: Growth hormone secretagogue receptor/motilin receptor (family) [25-353]
Sequence:
MRSRSGTMREGSAENRTGGESPLRLFPAPVLTGITVACVLLFVVGVLGNMMTMLVVSRFRDMRTTTNFYLSSMAFSDLLIFLCMPLDLFRLWQYRPWNFGDLLCKLFQFISESCTYSTILNITALSVERYVAICFPLRAKVIITKRKVKLVILILWAISFISAGPIFVLVGVEHENGTNPLSTNECRATEYAIRSGLLTIMVWISSIFFFLPVFCLTVLYSLIGRKLWRRKRKNIGPSTVIRDKNNKQTVKMLVVVVFAFILCWLPFHVGRYLFSKSFEAGSLEIAVISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAACRLFGLKTLPKKRLSSTKQDSSRVWTEPTVAT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0042562 (hormone binding), GO:0017046 (peptide hormone binding), GO:0042277 (peptide binding), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0007218 (neuropeptide signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Cell division protein ZipA (FtsZ interacting protein A) (P77173)
Organism: Escherichia coli (strain K12)
Function: Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of the downstream cell division proteins FtsK, FtsQ, FtsL and FtsN. ZipA overproduction protects FtsZ from degradation by ClpP by preventing recognition by ClpX. Does not affect the GTPase activity of FtsZ.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:9008158}; Single-pass type I membrane protein {ECO:0000269|PubMed:9008158}. Note=Localizes to the Z ring in an FtsZ-dependent manner (PubMed:10209756, PubMed:9008158, PubMed:9864327). Localization does not depend upon FtsA or FtsI (PubMed:10209756, PubMed:9864327). {ECO:0000269|PubMed:10209756, ECO:0000269|PubMed:9008158, ECO:0000269|PubMed:9864327}.
InterPro domains:
- IPR036765: ZipA, C-terminal FtsZ-binding domain superfamily (homologous_superfamily) [189-328]
- IPR011919: Cell division protein ZipA (family) [2-328]
- IPR007449: ZipA, C-terminal FtsZ-binding domain (domain) [191-320]
Sequence:
MMQDLRLILIIVGAIAIIALLVHGFWTSRKERSSMFRDRPLKRMKSKRDDDSYDEDVEDDEGVGEVRVHRVNHAPANAQEHEAARPSPQHQYQPPYASAQPRQPVQQPPEAQVPPQHAPHPAQPVQQPAYQPQPEQPLQQPVSPQVAPAPQPVHSAPQPAQQAFQPAEPVAAPQPEPVAEPAPVMDKPKRKEAVIIMNVAAHHGSELNGELLLNSIQQAGFIFGDMNIYHRHLSPDGSGPALFSLANMVKPGTFDPEMKDFTTPGVTIFMQVPSYGDELQNFKLMLQSAQHIADEVGGVVLDDQRRMMTPQKLREYQDIIREVKDANA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050794 (regulation of cellular process), GO:1900190 (regulation of single-species biofilm formation), GO:1900231 (regulation of single-species biofilm formation on inanimate substrate)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: FKBP-type peptidyl-prolyl cis-trans isomerase FkpA (PPIase) (EC 5.2.1.8) (Rotamase) (P45523)
Organism: Escherichia coli (strain K12)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular location: Periplasm.
InterPro domains:
- IPR036944: Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal domain superfamily (homologous_superfamily) [26-142]
- IPR000774: Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal (domain) [46-152]
- IPR046357: Peptidyl-prolyl cis-trans isomerase domain superfamily (homologous_superfamily) [143-257]
- IPR001179: FKBP-type peptidyl-prolyl cis-trans isomerase domain (domain) [159-249]
Sequence:
MKSLFKVTLLATTMAVALHAPITFAAEAAKPATAADSKAAFKNDDQKSAYALGASLGRYMENSLKEQEKLGIKLDKDQLIAGVQDAFADKSKLSDQEIEQTLQAFEARVKSSAQAKMEKDAADNEAKGKEYREKFAKEKGVKTSSTGLVYQVVEAGKGEAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDGVIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPGIPPNSTLVFDVELLDVKPAPKADAKPEADAKAADSAKK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0097159 (organic cyclic compound binding), GO:0033218 (amide binding), GO:1901363 (heterocyclic compound binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0016859 (cis-trans isomerase activity), GO:0003755 (peptidyl-prolyl cis-trans isomerase activity), GO:0005527 (macrolide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0006457 (protein folding), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0061077 (chaperone-mediated protein folding), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0018193 (peptidyl-amino acid modification), GO:0018208 (peptidyl-proline modification), GO:0000413 (protein peptidyl-prolyl isomerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0042597 (periplasmic space), GO:0030313 (cell envelope), GO:0030288 (outer membrane-bounded periplasmic space)