Protein: Chromatin remodeling protein SHL (Protein SHORT LIFE) (Q9FEN9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Chromatin remodeling factor that binds to methylated histone (e.g. H3K4me2/3) to prevent their acetylation (e.g. H3K9K14Ac), likely by recruiting histone deacetylase (HDAC) complexes, and thus regulate the transcription of target genes. Required during development and for fertility, probably by modulating developmental gene expression. Promotes development speed, but at fitness cost. Involved in the chromatin-mediated repression of floral initiation and controls genes regulating flowering. Negatively regulates the expression of the floral integrator SOC1, by preventing high levels of H3 acetylation, thus maintaining an inactive chromatin conformation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:11129039}.
InterPro domains:
- IPR001025: Bromo adjacent homology (BAH) domain (domain) [21-137]
- IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [130-191]
- IPR019787: Zinc finger, PHD-finger (domain) [139-190]
- IPR043151: Bromo adjacent homology (BAH) domain superfamily (homologous_superfamily) [1-133]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [134-205]
- IPR019786: Zinc finger, PHD-type, conserved site (conserved_site) [142-187]
- IPR001965: Zinc finger, PHD-type (domain) [141-188]
Sequence:
MPKQKAPRKQLKSYKLKHINKSIQEGDAVLMRSSEPGKPSYVARVEAIETDARGSHAKVRVRWYYRPEESIGGRRQFHGAKEVFLSDHFDFQSADTIEGKCKVHSFSSYTKLDSVGNDDFFCRFEYNSTTGAFDPDRVTVFCKCEMPYNPDDLMVQCEECSEWFHPSCIGTTIEEAKKPDNFYCEECSPQQQNLHNSNSTSNNRDAKVNGKRSLEVTKSKNKHTKRPG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0003676 (nucleic acid binding), GO:0042393 (histone binding), GO:0140030 (modification-dependent protein binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0035064 (methylated histone binding), GO:0003677 (DNA binding), GO:0140034 (methylation-dependent protein binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0009892 (negative regulation of metabolic process), GO:0007275 (multicellular organism development), GO:0009845 (seed germination), GO:2000241 (regulation of reproductive process), GO:2000242 (negative regulation of reproductive process), GO:0019222 (regulation of metabolic process), GO:0048583 (regulation of response to stimulus), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:0048585 (negative regulation of response to stimulus), GO:0009791 (post-embryonic development), GO:0048579 (negative regulation of long-day photoperiodism, flowering), GO:0048580 (regulation of post-embryonic development), GO:2000026 (regulation of multicellular organismal development), GO:2000028 (regulation of photoperiodism, flowering), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0090351 (seedling development), GO:0048581 (negative regulation of post-embryonic development), GO:0006325 (chromatin organization), GO:0048586 (regulation of long-day photoperiodism, flowering), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0040029 (epigenetic regulation of gene expression), GO:0045814 (negative regulation of gene expression, epigenetic)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)