Protein: Glycinin G1 (Glycinin 11S G1) (Glycinin A1aB1b) (allergen Gly m 6) [Cleaved into: Glycinin A1a subunit (Glycinin acidic 1a subunit); Glycinin Bx subunit (Glycinin basic x subunit) (Glycinin B1b subunit) (Glycinin basic 1b subunit)] (P04776)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Glycinin is the major seed storage protein of soybean. Glycinin basic peptides (GBPs), and, to a lower extent, glycinin exhibit antibacterial activity against Gram-negative and Gram-positive bacteria (e.g. L.monocytogenes, B.subtilis, E.coli and S.enteritidis) by forming pores and aggregating in transmembranes, leading to membrane permeability and, eventually, cell death.
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:29348620}. Protein storage vacuole {ECO:0000269|PubMed:29348620}. Note=Hexamers are assembled in the endoplasmic reticulum and later sorted to the protein storage vacuoles. {ECO:0000269|PubMed:29348620}.
InterPro domains:
- IPR022379: 11-S seed storage protein, conserved site (conserved_site) [310-332]
- IPR006045: Cupin 1 (domain) [36-472]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [19-494]
- IPR050253: Seed Storage and Functional Proteins (family) [7-485]
- IPR011051: RmlC-like cupin domain superfamily (homologous_superfamily) [5-480]
- IPR006044: 11-S seed storage protein, plant (family) [322-466]
Sequence:
MAKLVFSLCFLLFSGCCFAFSSREQPQQNECQIQKLNALKPDNRIESEGGLIETWNPNNKPFQCAGVALSRCTLNRNALRRPSYTNGPQEIYIQQGKGIFGMIYPGCPSTFEEPQQPQQRGQSSRPQDRHQKIYNFREGDLIAVPTGVAWWMYNNEDTPVVAVSIIDTNSLENQLDQMPRRFYLAGNQEQEFLKYQQEQGGHQSQKGKHQQEEENEGGSILSGFTLEFLEHAFSVDKQIAKNLQGENEGEDKGAIVTVKGGLSVIKPPTDEQQQRPQEEEEEEEDEKPQCKGKDKHCQRPRGSQSKSRRNGIDETICTMRLRHNIGQTSSPDIYNPQAGSVTTATSLDFPALSWLRLSAEFGSLRKNAMFVPHYNLNANSIIYALNGRALIQVVNCNGERVFDGELQEGRVLIVPQNFVVAARSQSDNFEYVSFKTNDTPMIGTLAGANSLLNALPEEVIQHTFNLKSQQARQIKNNNPFKFLVPPQESQKRAVA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0019865 (immunoglobulin binding), GO:0019863 (IgE binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0048856 (anatomical structure development), GO:0021700 (developmental maturation), GO:0007275 (multicellular organism development), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0009791 (post-embryonic development), GO:0048316 (seed development), GO:0016043 (cellular component organization), GO:0010431 (seed maturation), GO:0048608 (reproductive structure development), GO:0044085 (cellular component biogenesis), GO:0071695 (anatomical structure maturation), GO:0048731 (system development), GO:0071695 (anatomical structure maturation), GO:0061458 (reproductive system development), GO:0043933 (protein-containing complex organization), GO:0010154 (fruit development), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization), GO:0070206 (protein trimerization), GO:0070207 (protein homotrimerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005773 (vacuole), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0000322 (storage vacuole), GO:0000326 (protein storage vacuole)