lokahq/bioreason-rl huggingface dataset:
Protein: 2',3'-cyclic-nucleotide 3'-phosphodiesterase (A0A8M3B0U8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Lipid- anchor
InterPro domains:
- IPR047325: Cyclic nucleotide phosphodiesterase, catalytic domain (domain) [187-423]
- IPR008431: Cyclic nucleotide phosphodiesterase (family) [20-424]
- IPR009097: Cyclic phosphodiesterase (homologous_superfamily) [183-400]
Sequence:
MEAEQNQEVQEAVPETQEVAAQQEEKSEPKSEEAPQAPSEAAADPPAAATEPEKPQEREPSAEEQQKATESAAPPAKPSEPEAKSPEDSSEKTPEQQQKSSEEPSLQVNSEPEKQEEEAVKEAESKKEEPVKEADSKPAAVNEVKPEESEKSETTKAEGEKVQVPDSDGVQAEPPKEAEPEEKKPELPLFYGWFLLKEEEERIKCATMDFLKTLDTLEAFKEHISEFTSEANKEVDLEQYFQNPLPLHCTTKFCDYGKAEGAKEYAELQVVKEATGKSEELSVTALIVTPRTFGARVALTETQLNLWPEGEDKVGVAPTLLPGVESLPAGSRAHVTLGCSAGVEAVQTGLDLLEILVLQKEGKEGTQVEMDMGTLSYLSEGRWYLALREAITADTTFSSFSEDKPVSDQGKKDGEKKKKKCTIL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity), GO:0004112 (cyclic-nucleotide phosphodiesterase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0002040 (sprouting angiogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Mitogen-activated protein kinase kinase kinase 7 (A0A8M3AT57)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm
InterPro domains:
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [141-153]
- IPR049637: Mitogen-activated protein kinase kinase kinase 7 (family) [1-578]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [25-272]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [13-281]
- IPR017441: Protein kinase, ATP binding site (binding_site) [31-52]
- IPR000719: Protein kinase domain (domain) [25-280]
Sequence:
MSMPSADMLETPPMYPFEEIDYVDIEVEEVVGRGAFGVVCKAKWKGRDVAIKTIESESEKNAFIVELRQLSRVDHPNIVKLYGSCNNPVCLVMEYAEGGSLYNVLHGAEPLPHYTASHAMSWCLQCSQGVSYLHGMKPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHRGTRPPLIKNLPKAIESLMTRCWSKDPSQRPSMEEIVKIMSHLMGYFPGSEEPLKYPYQYSDEGQSNSATSTGSHLDYTCTSNKNDINMEHTNSPGSNDTIKFPYKPKGISGQSLSRGSSVESLPGRSHFQPSSDSKRMSVELSELEPRLPFASPARPQYKRGHRKTASHGTILDIPKIIVTATCEPHRRRSVQDLPAIGTDASQDSRNNSRSSSPSFRMITPDRTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYLKVQTEIALLKQRKEELIAELDQDEKDQQNACRLAQEQKKLIEENKSLSTYYQQCKKQLELIRAQQQKRQGTS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)
Protein: CXXC-type zinc finger protein 5 (A0A8M3AX14)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR002857: Zinc finger, CXXC-type (domain) [218-259]
- IPR040388: CXXC-type zinc finger protein CXXC4/CXXC5 (family) [61-284]
Sequence:
MSGGQPEGSRTPKAQDQDTDQDCGEDSPVIERRNRSGIISEPLSKSLKRSRTLSQYTAACPQTANGLKHNGQAKSHTAKPAQPAQQQPQQPSASALVPSKLDRTLEQVLEGQNGLLHFAQAAALLKRAGMEHMLLPGGMGVGVGGGEVGSVDLEGASVADTVGGHTDFPYGVGGGFPFNPGLFIMTPAGVFLADSALHMAGLTEYPVQSELASAISSGKKKRKRCGMCPPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPTGAAFRWFQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016491 (oxidoreductase activity), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0035295 (tube development), GO:0001525 (angiogenesis), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009799 (specification of symmetry), GO:0009790 (embryo development), GO:0035239 (tube morphogenesis), GO:0072001 (renal system development), GO:0009855 (determination of bilateral symmetry), GO:0060562 (epithelial tube morphogenesis), GO:0048568 (embryonic organ development), GO:0003007 (heart morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0060972 (left/right pattern formation), GO:0035050 (embryonic heart tube development), GO:0048562 (embryonic organ morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0001822 (kidney development), GO:0002040 (sprouting angiogenesis), GO:0007507 (heart development), GO:0061371 (determination of heart left/right asymmetry), GO:0048793 (pronephros development), GO:0007368 (determination of left/right symmetry), GO:0001947 (heart looping)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Protein kinase C and casein kinase substrate in neurons 3 (A0A8M2BE23)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm
InterPro domains:
- IPR001060: FCH domain (domain) [14-102]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [373-433]
- IPR001452: SH3 domain (domain) [374-435]
- IPR031160: F-BAR domain (domain) [8-280]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [1-302]
Sequence:
MSSNGDLQDVGSWDSFWEPGNYKRTVKRIDDGYKLCNELVSCFQERAKIEKGYSQQLSDWARKWRGIVEKGSQYGTLEKAWHAFMNAADRLSEIHMELKENLVIEDSEKIRNWQKDAFHKQMIGGFRETKDADEGFRKAQKPWVRKLKEVESTKKGYHSARKEERTALTRETHAKADPTKSQDEVRKFTDRLEKCTQEAEKAKERYERALDELNRCNPRYMEDMEQVFEITQEAEKNRLCFFKEVLLDIHQHMDLSSNDRFRALYRDLGQTISAANDTEDLRWWRNTHGPGMSMNWPQFEEWSPEANRSISRKDRNSRSDDVVTLTNIVSAGDEPPQTLQETTRAGKDYSSDWSDEESPKKYIAANGVDEEEKVVGVRVRALYDYTGQEADELSFKAGEELLKLGEEDEQGWCKGQLTSGEKGLYPANYVQIITS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009790 (embryo development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048568 (embryonic organ development), GO:0060034 (notochord cell differentiation), GO:0007399 (nervous system development), GO:0048562 (embryonic organ morphogenesis), GO:0048570 (notochord morphogenesis), GO:0030903 (notochord development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Estrogen receptor 2b (A0A8M2B359)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
- IPR001723: Nuclear hormone receptor (family) [226-516]
- IPR013088: Zinc finger, NHR/GATA-type (homologous_superfamily) [157-262]
- IPR028355: Estrogen receptor beta/gamma (family) [21-585]
- IPR021064: Estrogen receptor beta-like, N-terminal (domain) [31-132]
- IPR024178: Estrogen receptor/oestrogen-related receptor (family) [30-559]
- IPR050200: Nuclear hormone receptor family NR3 subfamily (family) [109-539]
- IPR000536: Nuclear hormone receptor, ligand-binding domain (domain) [304-540]
- IPR035500: Nuclear hormone receptor-like domain superfamily (homologous_superfamily) [299-548]
- IPR001628: Zinc finger, nuclear hormone receptor-type (domain) [162-237]
Sequence:
MSSSPGPAPVLDSSKADRGASPALLPRLYASPLGMDNQTVCIPSPYVEACQDYSPPHGGEFNHGALTLYSPVSSAVLGFHRPPVSESLVPLSPTILWPPHSLHCPPPLAYSETRSHSAWEEAKTHTLSQSSSVLSHTKLLGQQLEGDNGLNPSASIVGKGDTHFCAVCHDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKSRRKSCQACRLRKCYEVGMMKCGMQLTLRFCVRRERCSYRGARHRRNPQIRDSSGGVVGLRGQSQQHLEFPLSPSQHLFPSGGRAEGRGLNYSPEQLVSCILEAEPPQIYLREPVKKPYTEASMMMSLTSLADKELVLMISWAKKIPGFVELTLSDQVHLLECCWLDILMLGLMWRSVDHPGKLIFTPDLKLNREEGNCVEGIMEIFDMLLATTSRFRELKLQREEYVCLKAMILLNSNNCSSLPQTPEDVESRGKVLNLLDSVTDALVWIISRTGLSSQQQSIRLAHLLMLLSHIRHLSNKGIEHLSNMKRKNVVLLYDLLLEMLDANTSQSSRMLEDRQQSPENLHTSRPQPDLKDSDQETPHSPRAEETVNKTLHSSLLREDMDTN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0060089 (molecular transducer activity), GO:0003700 (DNA-binding transcription factor activity), GO:0008289 (lipid binding), GO:0038023 (signaling receptor activity), GO:0097159 (organic cyclic compound binding), GO:0042562 (hormone binding), GO:0003707 (nuclear steroid receptor activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0005496 (steroid binding), GO:0004879 (nuclear receptor activity), GO:0098531 (ligand-activated transcription factor activity), GO:1990239 (steroid hormone binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0043627 (response to estrogen)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: PHD finger protein 21A isoform X7 (A0A8M9PN25)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
- IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [482-550]
- IPR019786: Zinc finger, PHD-type, conserved site (conserved_site) [496-537]
- IPR001965: Zinc finger, PHD-type (domain) [495-538]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [485-540]
- IPR019787: Zinc finger, PHD-finger (domain) [493-540]
Sequence:
MMELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKKVVEQLRKELLVKQEPDLKPQTFAATTDGKTVLLTAACPASQPISGPPHNQGAPQKTLTVTPVITAKTLPLVLKAATSTMPASMATQRSAVAMVTAINNPTRPGANSDSQSTPINLQMASKLPNQDTDAGTRIVSKNVIVVQATTTSAQPIKVPQFVPPPRLTPRPTFQPQVRPKPPTPINVPIAPAPPPPMVAAPLIQRPLMLTTKLTSSLPASAGPIHQVRIVNGQQCTTIDKTTTTVTGTTQLAGIVISPAQTLQISNLNSDLKTVKPQGGPEQVVIKTPPSSSPPLPPPPAKVKREESPQKLAFMVSLGLVTHDHLEEIQSRRQERKRRTTANPVYSGAVFEPERKKSAVTYLNTPLHQGTRKRGRPPKYSTTTTTTTSSSTAVPELGCNPLLSPTSSLPASPAPERPDTGGFPLSVHPHSVPQPSPSSGDGDIHEDFCTVCRRSGQLLMCDTCSRVYHLDCLDPPLKNIPKGMWICPKCQDQILKKEEAIPWPGTLAIVHSYIAYKEAKEEEKQKLMKWSAELKLEREQLEQRVKQLSNSITKCMETKNSILARQKDMQASLEKVKHLVRLIQSFNFTQPMETETLKDSKQDCAESGSIKDSKDTTQVCVQESPTEPSVQVPAAVAVPEVKAEPEVGEMAEPAAAVTPEAVSGESGVSVLEVPKTTVDEDMMDTAKTVEPVESPQVRDVKTNGGTDCVCTGLNPEEESTVDAVDSENIPPIDSSCAEDAGKMEVELQEDGSHGMNTNNGKTSEPSQQALPAPLSSVDNPK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0060324 (face development), GO:0060322 (head development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Kinesin-like protein KIF14 (Q1LW14)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton, spindle. Midbody. Nucleus
InterPro domains:
- IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [37-406]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [478-582]
- IPR032405: Kinesin-associated (domain) [434-504]
- IPR000253: Forkhead-associated (FHA) domain (domain) [505-572]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [37-391]
- IPR056523: KIF14, four-helical bundle (domain) [951-1092]
- IPR019821: Kinesin motor domain, conserved site (conserved_site) [277-288]
- IPR001752: Kinesin motor domain (domain) [36-390]
Sequence:
MSSSTPHGGRRVEGHTPAEGLSKMSELQTQELKMENSAVTVAVRVRPFSSREKIEKACQVIFMENQDTLVQHPDTKQTHKFTFDFSFCSINEADASFSSQQLIYEKLARPLLERAFEGFNTCLFAYGQTGSGKSYTMMGFGEETGVIPRFCEELFSRLARSETKEMSCHLEMSYFEVYNEKIHDLLVAKDEQNQKKMPLRVREHPVYGPYVADLSTNVVSSYSDIKTWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEEEEHDHCITSRINLVDLAGSERCTSAQTSGDRLREGASINKSLLTLGKVISSLSEQSQSRKKVFTPYRESVLTWLLKESLGGNSKTAMIATLSPAASNMEESLSTLRYAQQARMIINIAKVNEDTNAKLIRDLKAEVEKLRAAQMSSQGVEPEKMRLFQQEIAALKNKLCQQEHEMAEAHRTWKEKLEEAERRKREEAKELQRAGVTFKVDNRLPNLVNLNEDPQLSEMLLYMIKEGQTKVGKLKSESAHDIQLSGALIADQHCVISSVKGTVSIKPMPNAKTFVNGHLVSECTVLHHGDRVILGGDHYFRFNHPAEVQSGKRASCWSSGDGHKDFEFAKNELLSAQRAQLEAEIQEARLKAKEEMMQGIQVAKEMAQKELSEQKSLYEIKIRALERELKEESERKREQELHKQRAASQIEQLQSVKTLLEKEVSSHKRRLQMEAQATRQAMADHDVRHAKIVAALEAEKRKIAEDLAQIEMKRALKVTQTPKMAIPQWDAMKLSLMIEEANKISGKLRKHTVFSRHEAADKEVEGGDAQLQVQVQNTKLGISTFWSLEKFQSNLAAMREIEQGESASKDDDVFYDPNDEWEPDLSASSSTSSFSRRRSRSLLKSRRISGRLYEIRVHPIQSLHCTPSQSTGLMNKPPSLHSSTSDSALPGICKDLIGSAVARLRSCQSADESESLADKLTLDLLSVHRAVRAITDLYEDLDDDSEENLFACSTEAQTHLVKATSAVERAVFITMHWVSSITFGSITVSQRAEELKMEVKKIGGYLQLLIQGCDSEISSMVTEARKRVAECMNAVFKTIGFLAAVNGTDLHLNEQNSEIIDNRSIVDCLQDGMRQSVKDLLSVGLLVTEEMLQVSHTGSTISKWMDVARSLQNYLRCCLSKSSDSSENHCVDYESSNLYDIQSTTTKLLKLNQAIKDLHSSLSRFLKGRRSDTSLSEAIQSSSQTIDKIISSLPHEITGRSDGLQLQDDVQSALQALLAVFSNSTDEIQKPTTDRHFVQSGYSSRNRTVPKVVYSLSSGISTCSRDARWV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding), GO:0030165 (PDZ domain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0048854 (brain morphogenesis), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Ubiquitin carboxyl-terminal hydrolase (Q1MT86)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR028889: Ubiquitin specific protease UPS, catalytic domain (domain) [324-851]
- IPR015940: Ubiquitin-associated domain (domain) [651-758]
- IPR018200: Ubiquitin specific protease, conserved site (conserved_site) [325-814]
- IPR050164: Ubiquitin carboxyl-terminal hydrolases (family) [179-851]
- IPR016652: Ubiquitinyl hydrolase (family) [15-851]
- IPR001607: Zinc finger, UBP-type (domain) [173-281]
- IPR009060: UBA-like superfamily (homologous_superfamily) [704-763]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [320-851]
- IPR001394: Peptidase C19, ubiquitin carboxyl-terminal hydrolase (domain) [324-848]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [2-268]
- IPR041432: Ubiquitinyl hydrolase, variant UBP zinc finger (domain) [15-77]
Sequence:
MTEVSEILMSVLSAIRVPRPGDRVHKDECAFSFSSPESEGGLYVCMNSFLGFGSKYVDRHHAKTGQRAYLHITRTRKTQKEDDPNSGSGDPPKKKPTRLAIGIEGGFDVEQEQYEEEVKVVLFPDRQEVTLDDLSSMPDVVRERVSLSVAELQAADSVSHTLQVQQWDGEVRQESKHAAELKQLDNGLKIPPSGWKCEVCELQENLWMNLTDGKVLCGRRYFDGSGGNNHALLYYQQTGYPLAVKLGTITPDGADVYSYDEDDMVLDSKLPEHLSHFGIDMMTMEKTERTMTELEIAVNQRVGEWEVIQESGTTLRPLWGPGLTGMKNLGNSCYLNSVMQVLFTIPDFQTKYVSNIDKIFDEAPSDPTQDFKTQVAKLGYGLLSGEYSKPAPDPADEPNTSAEPRGDQVGIAPRMFKALVGRGHPEFSTNRQQDAQEFLLHFINMVERNCRSGMNPSEAFRFLVEEKIVCQQSQKAKYTQRVDYIVQLPVPMDQATNMDELQEAERRREEAESSGAPPPVAPRAQIPFAACLAALSEPETLTDFWSSAVQAKTTATKTTRFASFPDHLVIQIKKFTFGLDWVPKKLDVSIDVPETLDLNALRAMGQQPGEELLPEVAPPPLMTPDVEVKGILGSHGNEEDDSLYSPLLSPVLDDSTVSQLCEMGFPLEACRKAVYYTGNTGIDAAMNWVMGHMDDPDFAAPLVLPGSSSAPGTTPTESLPEEHLATIVSMGFSRDQATRALRATNNVLERAVDWIFSHLDDLESMDVSEGGRSEGGSEASREPPPGPRVRDGTGKYELFAFISHMGSSTMCGHYVCHIKKDQQWVIFNDQKVCASEKPPKDLGYLYFYRRVVE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:1990380 (K48-linked deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:1904888 (cranial skeletal system development), GO:0003002 (regionalization), GO:0009953 (dorsal/ventral pattern formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: G protein-coupled receptor 186 (Q1LVV2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [54-293]
- IPR000723: G protein-coupled receptor 3/6/12 orphan (family) [39-305]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [54-301]
Sequence:
MDQNSSEVGLEVILAMNQLLDLPPSQMPPKPLEASVMTPWDITLCVSGVLICCENAIVVATIFSSSSLRAPMFLLIGSLAWADFLAGVGLLLHFLSRRCVYSEALELGSVGLLVSALSASVFSLLGITLDRFLSLHHALTYGSQRTHTQTRCALAVGWTLAGLQGALPALGWNCLHDGDSCSVLRPLTRVHLATLCGGFLLTLALLLQLNARICRVVLRHSHQIALQRHTLPSARTHTRRRVHTLALILATFASCWIPFALYGLLGDGSSPALYTYATLVPVTGNSLLNPLIYAYRNTHIQRVLRQTVCCCLPNTPNKNTHTPSDV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0006525 (arginine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)