lokahq/bioreason-rl huggingface dataset:
Protein: Gamma-secretase subunit APH-1 (APH-1) (Q5PQQ3)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369072}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369072}.
InterPro domains:
- IPR009294: Gamma-secretase subunit Aph-1 (family) [1-246]
Sequence:
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFVTAGGSLRSIQRSLSCKD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0007610 (behavior), GO:0007626 (locomotory behavior)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0008021 (synaptic vesicle), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0045202 (synapse), GO:0030133 (transport vesicle), GO:0042734 (presynaptic membrane), GO:0005739 (mitochondrion), GO:0098590 (plasma membrane region), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070382 (exocytic vesicle), GO:0005769 (early endosome), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)
Protein: E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (RING-type E3 ubiquitin transferase CHIP) (Q9XYW6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
InterPro domains:
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [12-119]
- IPR003613: U-box domain (domain) [212-286]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [210-289]
- IPR045202: CHIP , U-box domain (domain) [213-283]
- IPR041312: CHIP, N-terminal tetratricopeptide repeat domain (domain) [130-211]
- IPR019734: Tetratricopeptide repeat (repeat) [14-115]
Sequence:
MTTKHIYSTTNLSDLQLKEQGNCLFAARKYDDAINCYSKAIIKNPTNATYFTNRALCNLKLKRWELCCQDSRRALDIDGNLLKGHFFLGQGLMEIDNFDEAIKHLQRAYDLSKEQKQNFGDDITLQLRLARKKRWNVMEEKRIQQEIELQSYLNGLIKGDMESRLANLKLNGNVHDEQLKDKQQEIEQECDDHIKELNNIFSKVDERRKKREVPDFLCGKISFEILTDPVITPSGITYERKDIEEHLQRVGHFDPVTRVKLTQDQLIPNFSMKEVVDSFIAENEWSLDY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030017 (sarcomere), GO:0031674 (I band), GO:0030018 (Z disc), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: Regulator of G-protein signaling 8 (RGS8) (P49804)
Organism: Rattus norvegicus (Rat)
Function: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12880183}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Membrane {ECO:0000269|PubMed:9394004}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Perikaryon {ECO:0000269|PubMed:12880183}. Cell projection, dendrite {ECO:0000269|PubMed:12880183}. Nucleus {ECO:0000269|PubMed:12880183}. Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1. {ECO:0000269|PubMed:12880183}.
InterPro domains:
- IPR044926: RGS, subdomain 2 (homologous_superfamily) [83-152]
- IPR016137: RGS domain (domain) [53-172]
- IPR034949: Regulator of G-protein signalling 8, RGS domain (domain) [46-170]
- IPR024066: RGS, subdomain 1/3 (homologous_superfamily) [45-169]
- IPR036305: RGS domain superfamily (homologous_superfamily) [42-174]
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0019900 (kinase binding), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0010646 (regulation of cell communication), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0009966 (regulation of signal transduction), GO:0097305 (response to alcohol), GO:0008277 (regulation of G protein-coupled receptor signaling pathway), GO:0045471 (response to ethanol)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0098857 (membrane microdomain), GO:0045121 (membrane raft)
Protein: Protein OXIDATIVE STRESS 3 LIKE 6 (AtO3L6) (KID-containing protein-like 2) (AtKCL2) (Q945P6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable transcription factor (By similarity). Promotes slightly the tolerance to cadmium (Cd) and to oxidizing chemicals (e.g. diamide).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
InterPro domains:
- IPR051992: Oxidative Stress Response Regulator (family) [59-232]
Sequence:
MEVMVGSSFGIGMAAYVRDHRGVSAQDKAVQTALFLADESGRGGSQIGIGLRMSNNNNKSPEESSDSSSSIGESSENEEEEEEDDAVSCQRGTLDSFSSSLEDSLPIKRGLSNHYVGKSKSFGNLMEAASKAKDLEKVENPFNKRRRLVIANKLRRRGRSMSASNFYSWQNPNSMPLLALQEPNEEDHHIHNDDYEDDDGDGDDHRKIMMMMKNKKELMAQTRSCFCLSSLQEEDDGDGDDDEDE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006979 (response to oxidative stress), GO:0010035 (response to inorganic substance), GO:0010038 (response to metal ion), GO:0010043 (response to zinc ion), GO:0046686 (response to cadmium ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Bub3 interacting GLEBS and zinc finger domain protein, isoform A (GH18623p) (Q9VJI6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
InterPro domains:
- IPR013087: Zinc finger C2H2-type (domain) [11-58]
- IPR003656: Zinc finger, BED-type (domain) [6-65]
Sequence:
MGRKKKKASKPWCWYCNREFDDEKILVQHQKAKHFKCHICHKKLYTGPGLSIHCMQVHKETVDKVPNSLPNRSNIEVEIFGMDGIPAEDLRDHERQKNGGKSDSDDDEPVAKKKVEYAMSVPPPMMMPPNMMPPHMLGQYGMGMMQHMPPLPPYPVPMMPHMMPPRPLFPAAMATTSAAAAAAAAHHHHAAAMAQQKPTFPAYSNATISAPPTTNHAGGASSAPPSGPPDAQQHQQRPPAPPAASGTSAAAVTTKIMHPQEDLSLEELRARQPKIQARLAAALASLANPQSRKSPSNNGGPSTSIPTTPPPPSLAGISPTGSNSSSGMANSIVVSAAMSKAQEVSSYHSYRNHSQYK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0016043 (cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0016358 (dendrite development), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0048813 (dendrite morphogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0032990 (cell part morphogenesis), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048699 (generation of neurons), GO:0031175 (neuron projection development), GO:0048812 (neuron projection morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: ATP-dependent zinc metalloprotease FTSH 1 (EC 3.4.24.-) (Q8I526)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
InterPro domains:
- IPR000642: Peptidase M41 (domain) [404-587]
- IPR003593: AAA+ ATPase domain (domain) [181-322]
- IPR041569: AAA ATPase, AAA+ lid domain (domain) [345-384]
- IPR003959: ATPase, AAA-type, core (domain) [185-320]
- IPR037219: Peptidase M41-like (homologous_superfamily) [398-597]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [127-391]
- IPR005936: ATP-dependent zinc metalloprotease, FtsH (family) [1-593]
- IPR003960: ATPase, AAA-type, conserved site (conserved_site) [290-308]
Sequence:
MSSKYDNQSFLSTGSDKYGEQENSVLLHDEEDEYINENKKKRNERDKKFRYYENFFNRRRSKKWNYFIIFFLGVCLGFAIWPFFMTIITYRLFYKDNFNNTNYRTNNSSTSLKSYGNEKNKKSDNNGKVPMKDQSPNKVSPHFKPIRFEEIAGIDESKLELLEVVDFIKNREKYHEMGARMPKGVLLVGPPGSGKTMLARAVATEANVPYIYTSGPEFIEIYVGQGAKRIRQLFAHARSVAPSIVFIDEIDAIGGKRSSGSVNGAGQREHDQTLNQLLVEMDGFSNTVHIMVIGATNRIDTLDSALLRPGRFDRIVYVPLPDINGRKKILEIYIKKIKSDLKLEDIEKIARLTPGFSGADLENVVNEATILATRNNKSLVTINELYEARDKVSMGPERKSLRQSDHQRRITAYHEAGHAIVAYFLQPKTDPIHKATIISRGNALGYVEQIPVDDRHNYFKSQMEAKLAVCMGGRTAEEIVFGKSETSSGASSDISRATEIAYKMVTEWGMSDKLGPLNYKKRMGDGYSSNRLSAQTVSSIEVEVKSLVEKGKSLSEEILRRHRKELDNLAFALLDKETLSGEEIKNIIDPNNSKNYSGKVEMLKNDTKKNEKKSNSVSKNKSTISEDYDKNQNNVEQNYQSHDHTLVKNEENLNNMKNDIDDNNTRDGQVNSDSFVKRKEVTDQDINGKELSEMDNKEIKENKKLDGEELNKIIIDNDKMGDMKKNIKEVIKKMKKKQSKGSYKTYKNVLKSVSEHKELKTQKKADENKIVADNNEKSSNNSLDKNNTQGSIDEKGYKNNNNNNNNMVKNINELFEENFPEYKKYDNENNDFVKTKENYFDNFNEVIDISHIKNVDEMKKFNIFEHNLNKLFLFDIFKSD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0006457 (protein folding), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0030163 (protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Cytochrome c (P53698)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
InterPro domains:
- IPR009056: Cytochrome c-like domain (domain) [8-109]
- IPR036909: Cytochrome c-like domain superfamily (homologous_superfamily) [5-110]
- IPR002327: Cytochrome c, class IA/ IB (family) [6-108]
Sequence:
MPAPFEKGSEKKGATLFKTRCLQCHTVEKGGPHKVGPNLHGVFGRKSGLAEGYSYTDANKKKGVEWTEQTMSDYLENPKKYIPGTKMAFGGLKKPKDRNDLVTYLKKATS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055072 (iron ion homeostasis), GO:0055080 (monoatomic cation homeostasis), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Cytokine induced apoptosis inhibitor 1 (H3BQ23)
Organism: Homo sapiens (Human)
Function: Not known
InterPro domains:
- IPR007785: Anamorsin (family) [7-128]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [1-129]
- IPR049011: Anamorsin, N-terminal domain, metazoan-type (domain) [9-129]
Sequence:
MADFGISAGQFVAVVWDKSSPVEALKGLVDKLQALTGNEGRVSVENIKQLLQSAHKESSFDIILSGLVPGSTTLHSAEILAEIARILRPGGCLFLKEPVETAVDNNSKVKTASKLCSALTLSGLVEVKE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0043414 (macromolecule methylation), GO:0016043 (cellular component organization), GO:1901564 (organonitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0043933 (protein-containing complex organization), GO:0006479 (protein methylation), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0008213 (protein alkylation), GO:0018193 (peptidyl-amino acid modification), GO:0018195 (peptidyl-arginine modification), GO:0018205 (peptidyl-lysine modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Ubiquitin carboxyl-terminal hydrolase family protein (Q9FM53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
InterPro domains:
- IPR021099: Plant organelle RNA recognition domain (domain) [60-397]
- IPR045040: PORR family (family) [56-430]
Sequence:
MMMALTQLVPSSPEKLFCFSSFFLPSIPLEIRRSNVTTKTSSKKLGSLSLNISCSAHKIVRSPSLDRHVVKQNRVRFVQKLNTLLLSKPKHYIPIEILYKCRSYLCIENPLAILSMIRRYPTIFELFTTPTPHLPMNATKPLSQLCVRLTSAASSLAMQELNLKSEISDKLATKLQKLLMLSSHRRLLLSKLVHIAPDFGFPPNFRSRLCNDYPDKFKTVDTSYGRALELVSSDPELANQMPSPEVDRGLIVDRPLKFKRLNLRRGLNLKRRHQGFLIKFRESPDVCPYKMSSDYLASESIEAEKRACAVVREVLGLTVEKRTLIDHLTHFRKEFSLPNKLRDLIVRHPELFYVSIKGMRDSVFLVEAYNDNGDLLDKDERLVIRERLIDLIQEGKRIRRERRRKGATLGDKSVEEKRKDDETIDDYDSDLDDEYEDGFENLFDSEDLGVEYHFDEEDDDDEAGVNGESVEYWSRKLSSSGSSSDEANSAVESW
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile), GO:0000373 (Group II intron splicing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Sphingolipid delta(4)-desaturase DES1-like (EC 1.14.19.17) (Q9ZPH4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sphingolipid-delta-4-desaturase required for the biosynthesis of delta-4-unsaturated sphingolipids and derivatives. May be required for the biosynthesis of glucosylceramides.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
InterPro domains:
- IPR011388: Sphingolipid delta4-desaturase (family) [1-332]
- IPR005804: Fatty acid desaturase domain (domain) [79-297]
- IPR013866: Sphingolipid delta4-desaturase, N-terminal (domain) [19-57]
Sequence:
MGKGGREKISSNEEEREGVMATDFFWSYTDEPHASRRRQILSCYPQIRQLFGPDPWAFLKITLVVILQLSTAAILHNSGWLKILSIAYFFGSFLNHNLFLAIHELSHNLAFSTPVYNRCLGIFANLPIGVPMSVTFQKYHLEHHRFQGVDGIDMDVPTYTEAHLVTNIFAKTIWVFLQLFFYALRPIFIKPKPPGYWEFINFLIQIVLDVSVVLFFGWRSFAYLILSTFVGGGMHPMAGHFISEHYVFNPNQETYSYYGPLNLLTWSVGYHNEHHDFPRIPGNKLHLVKEIAGEYYEGLESYKSWSQVIYMYIMDTTVGPYSRMKRKLSKSD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006665 (sphingolipid metabolic process), GO:0046467 (membrane lipid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006643 (membrane lipid metabolic process), GO:0030148 (sphingolipid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)