lokahq/bioreason-rl huggingface dataset:
Protein: SUEL-type lectin domain-containing protein (A0A060XUW4)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Not known
InterPro domains:
- IPR000922: D-galactoside/L-rhamnose binding SUEL lectin domain (domain) [54-238]
- IPR043159: D-galactoside/L-rhamnose binding SUEL lectin domain superfamily (homologous_superfamily) [49-240]
Sequence:
MSCPNQFRVTSRCDGNEKCDVATSGSVCDLCSTAYLTNIFLDVTYGCLESKKVTTCHGVVHLECGDGVVFLQKALYGRIDSQTCSQGRPQSELTNTKCSQEGTLALWSQRCDGKQTCEVNMRVNQISDPCVGTYKYLDVTYICLPAKTSITCEGSTSSLDCGKGVIKVFHANYGRRDGSTCSAGRHELSNQNCLQPKTLDVVKQWCEGKSQCTVGLDPVFGDPCYGTYKYLEVSYTCLGVSPTV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0030246 (carbohydrate binding), GO:0005515 (protein binding), GO:0070492 (oligosaccharide binding), GO:0048029 (monosaccharide binding), GO:0046983 (protein dimerization activity), GO:0042802 (identical protein binding), GO:0042803 (protein homodimerization activity), GO:0048030 (disaccharide binding), GO:0005534 (galactose binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0007155 (cell adhesion), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0098609 (cell-cell adhesion), GO:0043933 (protein-containing complex organization), GO:0034109 (homotypic cell-cell adhesion), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0070206 (protein trimerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0098562 (cytoplasmic side of membrane), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0098595 (perivitelline space), GO:0009898 (cytoplasmic side of plasma membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005634 (nucleus), GO:0097708 (intracellular vesicle), GO:0043073 (germ cell nucleus), GO:0001674 (female germ cell nucleus), GO:0042585 (germinal vesicle)
Protein: Anti-sigma-F factor antagonist RsfA (Anti-anti-sigma F factor RsfA) (P9WGE3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Positive, redox-sensitive regulator of sigma-F (SigF) activity. When reduced binds to anti-sigma-F factor RsbW (UsfX) preventing its binding to SigF, thus activating transcription.
InterPro domains:
- IPR036513: STAS domain superfamily (homologous_superfamily) [13-128]
- IPR002645: STAS domain (domain) [17-128]
- IPR003658: Anti-sigma factor antagonist (family) [16-122]
Sequence:
MNPTQAGSFTTPVSNALKATIQHHDSAVIIHARGEIDAANEHTWQDLVTKAAAATTAPEPLVVNLNGLDFMGCCAVAVLAHEAERCRRRGVDVRLVSRDRAVARIIHACGYGDVLPVHPTTESALSAT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)
Protein: Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) (Q8BG95)
Organism: Mus musculus (Mouse)
Function: Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O60237}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:O60237}. Note=Along actomyosin filaments. {ECO:0000250|UniProtKB:O60237}.
InterPro domains:
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [11-317]
- IPR051226: Protein Phosphatase 1 Regulatory Subunit (family) [6-976]
- IPR002110: Ankyrin repeat (repeat) [56-306]
- IPR017401: Protein phosphatase 1 regulatory subunit 12A/B/C (family) [10-976]
- IPR031775: cGMP-dependent protein kinase, interacting domain (domain) [875-976]
Sequence:
MAELEHLGGKRAESARARRAEQLRRWRGSLTEQEPAERQGAGRQLQTRRGSPRVRFEDGAVFLAACSSGDTDEVKKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFISHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGRIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDHDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEMLQKKQDVLRSEKETRNKLIESDLNSKFQSGLFKNKEKMLYEEEIPKSQDTEEENKESSSSSSEEEEGEDEVSESETEKEADKKPEATVNHSNSEIKSRIMEQIPAPAQNTFSASSARRLSSLFNKAEEPKDESPSSWRLGLRKTGSHNMLSEVANSREALRDRGSSIYRSSSSPRISALLDDKDKERENKSYFSMLVPRRLSSTSDIEEKENRESAVNLVRSGSHTRQLWRDEAKGSETPQTIAPSTYTSTYLKRTPYKSQADSTAEKTADSVSSSTPLCVITNRPAPSTANGVPAATVFSSAGTDPSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAEKTFSRSRAERQAQEQPGEKLEDPGGLEGSTKKQEPSAAPTKGAGEGRSLEEEPIYHRLRYPTQPDKPTTPVSPSASRPSLYTGSHLLRTSRASGPDSENSETSTHATAAKEMDTSEKGEADLDDQSSNRLSVRERRRAKDRRRGTGINFWTNDEDETDVSEEVKEALHERLSRLESGGTNPTSSDSYSDRASARARREAREARLASLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKAKLEKMAQQKQEKTSDRSSVLEVEKRERRALERKMSEMEEEMKVLTELKSDNQRLKDENGALIRVISKLSK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0051239 (regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0044057 (regulation of system process), GO:0090257 (regulation of muscle system process), GO:0006937 (regulation of muscle contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030017 (sarcomere), GO:0031674 (I band), GO:0030018 (Z disc), GO:0005737 (cytoplasm), GO:0031672 (A band), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) (O44953)
Organism: Caenorhabditis elegans
Function: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Dispensable for SPC enzymatic activity (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P83362}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P83362}.
InterPro domains:
- IPR009542: Signal peptidase complex subunit 1 (family) [8-103]
Sequence:
MDGMIAMLPAPLQKLSSHIDFQGQKVAERTYQVILTIAGIIGFLVGFWTQQLSYAMFTVLGASAFTALIILPPWPFLFRKNPIVWHTPAEPQESGDKKKETKKTK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH) (Q9HBB8)
Organism: Homo sapiens (Human)
Function: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:24725409}. Cell projection, microvillus membrane {ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:32209652}; Single-pass type I membrane protein {ECO:0000269|PubMed:24725409}.
InterPro domains:
- IPR050174: Protocadherin/Cadherin-related Cell Adhesion (family) [68-316]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [65-342]
- IPR020894: Cadherin conserved site (conserved_site) [112-122]
- IPR002126: Cadherin-like (domain) [29-459]
Sequence:
MGSWALLWPPLLFTGLLVRPPGTMAQAQYCSVNKDIFEVEENTNVTEPLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHNTVTSGTATTVIEIQVSEQEPPSTDVPPSPEAGGTTGPWTSTTSEVPRPPEPSQGPSTTSSGGGTGPHPPSGTTLRPPTSSTPGGPPGAENSTSHQPATPGGDTAQTPKPGTSQPMPPGVGTSTSHQPATPSGGTAQTPEPGTSQPMPPSMGTSTSHQPATPGGGTAQTPEAGTSQPMPPGMGTSTSHQPTTPGGGTAQTPEPGTSQPMPLSKSTPSSGGGPSEDKRFSVVDMAALGGVLGALLLLALLGLAVLVHKHYGPRLKCCCGKAPEPQPQGFDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGGAPEPPAAARAGGSPTAVRSILTKERRPEGGYKAVWFGEDIGTEADVVVLNAPTLDVDGASDSGSGDEGEGAGRGGGPYDAPGGDDSYI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0071944 (cell periphery), GO:0005576 (extracellular region), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)
Protein: Epsin-1 (EPS-15-interacting protein 1) (O88339)
Organism: Rattus norvegicus (Rat)
Function: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis (By similarity).
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Membrane, clathrin-coated pit. Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Colocalizes with clathrin at the Golgi complex. Detected in presynaptic nerve terminals and in synaptosomes. May shuttle to the nucleus when associated with ZBTB16/ZNF145.
InterPro domains:
- IPR003903: Ubiquitin interacting motif (conserved_site) [183-252]
- IPR013809: ENTH domain (domain) [12-144]
- IPR008942: ENTH/VHS (homologous_superfamily) [1-144]
Sequence:
MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQPPSCGPEDDVQLQLALSLSREEHDKEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTTPAPPQASDPWGGPASVPTAVPVAAAASDPWGAPAVPPAADPWGGAAPTPASGDPWRPAAPTGPSVDPWGGTPAPAAGEGPTSDPWGSADGGAPVSGPPSSDPWAPAPAFSDPWGGSPAKPSSNGTAVGGFDTEPDEFSDFDRLRTALPTSGSSTGELELLAGEVPARSPGAFDMSGVGGSLAESVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPSGAPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0060627 (regulation of vesicle-mediated transport), GO:0051049 (regulation of transport), GO:0030100 (regulation of endocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098793 (presynapse), GO:0019898 (extrinsic component of membrane), GO:0071944 (cell periphery), GO:0005886 (plasma membrane), GO:0042734 (presynaptic membrane), GO:0019897 (extrinsic component of plasma membrane), GO:0098590 (plasma membrane region), GO:0045202 (synapse), GO:0097060 (synaptic membrane), GO:0099243 (extrinsic component of synaptic membrane), GO:0098888 (extrinsic component of presynaptic membrane), GO:0031594 (neuromuscular junction)
Protein: adenylate cyclase (EC 4.6.1.1) (M9PBA8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
InterPro domains:
- IPR001054: Adenylyl cyclase class-3/4/guanylyl cyclase (domain) [254-488]
- IPR029787: Nucleotide cyclase (homologous_superfamily) [248-490]
Sequence:
MNKKNTYKTPYRERFRRCNLEYTNERLWEQSYLKARCKELHLEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKYIYINAIFDLGSLILVTGLLSINFFEDFVIRHRWVMTFTSTLSAYVVVLGDIAFNTYYYYKSNWPLNTLYDVFVLCMIYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTAIPSLDSDKTISIVEGVPNLDLQTVGSNRKSQILKPNLLSHEMREEFRKMPVGGFKFQFPWSRRERNLKNEKVERDLGIFCVAFKDKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICWYKKVCWWHSGQNEHRSYGKLSCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYELDIIESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARIPFALKTFIGCAEAVVFVLVVCFQYAFIFEHSVTTSPYLKAEIAHSCRVCMMLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVLFRSRGISQLYSQTRTLL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0009975 (cyclase activity), GO:0004016 (adenylate cyclase activity), GO:0016849 (phosphorus-oxygen lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0019953 (sexual reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007283 (spermatogenesis), GO:0048232 (male gamete generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Forkhead box O4 (A0A096MJF0)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
InterPro domains:
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [52-132]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [54-128]
- IPR030456: Fork head domain conserved site 2 (conserved_site) [95-101]
- IPR001766: Fork head domain (domain) [44-140]
- IPR032067: FOXO protein, transactivation domain (domain) [409-448]
Sequence:
MEPENKKSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPELATEPPEPSEVEPSLGQKAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPDGGKGGKAPRRRAASMDSSSKLLRGRSKGPKKKPSVLPAPPEGATPRSPLGHFAKWSSSPCPRNREEADVWTTFRPRSSSNASTVSTRLSPMRPESEVLAEEEMPASASSYAGGVPPTLSEDLELLDGLNLASPHSLLSRSNLSSFSLQHPGLAGPLHSYGASLFGPIDGSLSAGEGCFSSSQSLEALLTSDTPPPPADVLMTQVDPILSQAPTLLLLGGMPSSSKLATGVSLCPTPLEGPGPSNLVPTLSVMAPPPVMPGAPIPKVLGTPVLASPTEDFSHDRMPQDLDLDMYMENLECDMDNIISDLMDGEGLDFNFEPDP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding), GO:0005515 (protein binding), GO:1990841 (promoter-specific chromatin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0007568 (aging), GO:0040017 (positive regulation of locomotion), GO:0040012 (regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009991 (response to extracellular stimulus), GO:2000145 (regulation of cell motility), GO:2000147 (positive regulation of cell motility), GO:0035902 (response to immobilization stress), GO:0030335 (positive regulation of cell migration), GO:0030334 (regulation of cell migration), GO:0031667 (response to nutrient levels), GO:0014910 (regulation of smooth muscle cell migration), GO:0014911 (positive regulation of smooth muscle cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) (Sid 329) (Q9R0Q6)
Organism: Mus musculus (Mouse)
Function: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q92747}. Nucleus {ECO:0000250|UniProtKB:Q8AVT9}.
InterPro domains:
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [1-370]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [6-361]
- IPR001680: WD40 repeat (repeat) [41-356]
- IPR017383: Actin-related protein 2/3 complex subunit 1 (family) [1-362]
Sequence:
MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWTKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGIWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGNRLAWVSHDSTVSVADASKSVQVSTLRTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDVPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0030036 (actin cytoskeleton organization), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005885 (Arp2/3 protein complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)