Protein: Speedy protein 1-B (Spy1-B) (Protein Ls27) (Rapid inducer of G2/M progression in oocytes B) (RINGO-B) (XSpy1-B) (p33 ringo-B) (xRINGO-B) (Q9YGL1)
Organism: Xenopus laevis (African clawed frog)
Function: Stimulates oocyte maturation by promoting meiotic G2/M progression in resting oocytes, via activation of the MAPK cascade and cdc2-cyclin B. Also activates the kinase activity of cdk2; this activation does not appear necessary for oocyte maturation. Necessary for polyadenylation in oocytes.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q5MJ70}.
InterPro domains:
- IPR052316: Speedy/Ringo cell cycle regulator (family) [1-275]
- IPR020984: Speedy (family) [63-192]
Sequence:
MRHMQSATRATLVCGSGVKQIIAKGHPNTRVFGARKARIPEREVLAAKPKITRITHLNLQPQERQAFYRLLENELIQEFLSMDSCLKISDKYLIAMVLAYFKRAGLYTGEYTTMNFFVALYLANDMEEDEEDYKYEIFPWALGDSWREFFPQFLRLRDNFWAKMNYRAVVSRRCCDEVMAKDPTHWAWLRDRPIHHSGALRGYLRNEDDFFPRGPGLTPASCALCHKASVCDSGGVAHDNSSPEQEIFHYTNREWSQELLILPPELLLDPESTYDIHIFQEPLVGLEPDGAALEWHHL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0030332 (cyclin binding), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0051321 (meiotic cell cycle), GO:2000241 (regulation of reproductive process), GO:0048584 (positive regulation of response to stimulus), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:2000243 (positive regulation of reproductive process), GO:0044237 (cellular metabolic process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0021700 (developmental maturation), GO:1903046 (meiotic cell cycle process), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0061982 (meiosis I cell cycle process), GO:0007276 (gamete generation), GO:0009967 (positive regulation of signal transduction), GO:0007281 (germ cell development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0009966 (regulation of signal transduction), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0045787 (positive regulation of cell cycle), GO:0071695 (anatomical structure maturation), GO:0051726 (regulation of cell cycle), GO:1901360 (organic cyclic compound metabolic process), GO:0051445 (regulation of meiotic cell cycle), GO:0006139 (nucleobase-containing compound metabolic process), GO:0010646 (regulation of cell communication), GO:0048469 (cell maturation), GO:0044770 (cell cycle phase transition), GO:0010647 (positive regulation of cell communication), GO:0009994 (oocyte differentiation), GO:0001556 (oocyte maturation), GO:0051446 (positive regulation of meiotic cell cycle), GO:0048477 (oogenesis), GO:0007292 (female gamete generation), GO:0044839 (cell cycle G2/M phase transition), GO:0090304 (nucleic acid metabolic process), GO:0048599 (oocyte development), GO:1902533 (positive regulation of intracellular signal transduction), GO:0010467 (gene expression), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0043410 (positive regulation of MAPK cascade), GO:0031123 (RNA 3'-end processing), GO:0043631 (RNA polyadenylation), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0006378 (mRNA polyadenylation), GO:0031124 (mRNA 3'-end processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0070971 (endoplasmic reticulum exit site), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)