lokahq/bioreason-rl huggingface dataset:
Protein: Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Q9JMI1)
Organism: Rattus norvegicus (Rat)
Function: Converts acetoacetate to acetoacetyl-CoA in the cytosol. Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:10682835, ECO:0000269|PubMed:3082367}.
InterPro domains:
- IPR042099: ANL, N-terminal domain (homologous_superfamily) [25-541]
- IPR005914: Acetoacetyl-CoA synthase (family) [16-671]
- IPR032387: Acetyl-coenzyme A synthetase, N-terminal domain (domain) [47-104]
- IPR000873: AMP-dependent synthetase/ligase domain (domain) [110-490]
- IPR045851: AMP-binding enzyme, C-terminal domain superfamily (homologous_superfamily) [543-663]
- IPR020845: AMP-binding, conserved site (conserved_site) [287-298]
Sequence:
MSKLARLEREEIMECQVMWEPDSKKDTQMDRFRAAVGTACGLALGNYDDLYHWSVRSYSDFWAEFWKFSGIVCSRMYDEVVDTSKGIADVPEWFRGSRLNYAENLLRHKENDRVALYVAREGREEIAKVTFEELRQQVALFAAAMRKMGVKKGDRVVGYLPNSAHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHGHLEKLQRVVKGLPDLQRVVLIPYVLPREKIDISKIPNSMFLDDFLASGTGAQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHVLHGNMTSSDILLYYTTVGWMMWNWMVSALATGASLVLYDGSPLVPTPNVLWDLVDRIGITILGTGAKWLSVLEEKDMKPMETHNLHTLHTILSTGSPLKAQSYEYVYRCIKSTVLLGSISGGTDIISCFMGQNSSIPVYKGEIQARNLGMAVEAWDEEGKTVWGASGELVCTKPIPCQPTHFWNDENGSKYRKAYFSKYPGVWAHGDYCRINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVEAFDEVEDSLCVPQYNRDGEERVVLFLKMASGHTFQPDLVKHIRDAIRLGLSARHVPSLILETQGIPYTINGKKVEVAVKQVIAGKTVEHRGAFSNPESLDLYRDIPELQDF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0016877 (ligase activity, forming carbon-sulfur bonds), GO:0016878 (acid-thiol ligase activity), GO:0016405 (CoA-ligase activity), GO:0003987 (acetate-CoA ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0006541 (glutamine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: SPI-2 type 3 secretion system translocon protein SctB (SPI-2 T3SS translocon protein SctB) (Secreted effector protein SseD) (Secretion system effector D) (Q9R803)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. May act as a translocator that mediates translocation of SPI-2 TTSS effector proteins from intraphagosomal bacterial cells into the host cells.
Subcellular location: Secreted {ECO:0000269|PubMed:11159962, ECO:0000269|PubMed:11567004}. Cell surface {ECO:0000269|PubMed:11159962, ECO:0000269|PubMed:11567004}. Host membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Note=Secreted via the type III secretion system 2 (SPI-2 T3SS) (PubMed:11159962, PubMed:11567004). After secretion, localizes mainly on the surface of the bacterial cell (PubMed:11159962, PubMed:11567004). {ECO:0000269|PubMed:11159962, ECO:0000269|PubMed:11567004}.
InterPro domains:
- IPR008611: SPI-2 type 3 secretion system translocon protein SctB-like (family) [38-195]
Sequence:
MEASNVALVLPAPSLLTPSSTPSPSGEGMGTESMLLLFDDIWMKLMELAKKLRDIMRSYNVEKQRLAWELQVNVLQTQMKTIDEAFRASMITAGGAMLSGVLTIGLGAVGGETGLIAGQAVGHTAGGVMGLGAGVAQRQSDQDKAIADLQQNGAQSYNKSLTEIMEKATEIMQQIIGVGSSLVTVLAEILRALTR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0055085 (transmembrane transport), GO:0140352 (export from cell), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0032940 (secretion by cell), GO:0045184 (establishment of protein localization), GO:0071806 (protein transmembrane transport), GO:0006810 (transport), GO:0030254 (protein secretion by the type III secretion system), GO:0035592 (establishment of protein localization to extracellular region), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0009306 (protein secretion), GO:0015031 (protein transport), GO:0071692 (protein localization to extracellular region)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: DNA-(apurinic or apyrimidinic site) endonuclease (EC 3.1.-.-) (E5KN95)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU362131}. Cytoplasm {ECO:0000256|RuleBase:RU362131}. Mitochondrion {ECO:0000256|RuleBase:RU362131}.
InterPro domains:
- IPR010666: Zinc finger, GRF-type (domain) [467-518]
- IPR004808: AP endonuclease 1 (family) [2-313]
- IPR005135: Endonuclease/exonuclease/phosphatase (domain) [5-304]
- IPR036691: Endonuclease/exonuclease/phosphatase superfamily (homologous_superfamily) [1-312]
- IPR020847: AP endonuclease 1, binding site (binding_site) [41-50]
Sequence:
MLRVVSWNINGIRRPLQGVANQEPSNCAAVAVGRILDELDADIVCLQETKVTRDALTEPLAIVEGYNSYFSFSRNRSGYSGVATFCKDNATPVAAEEGLSGLFATQNGDVGCYGNMDEFTQEELRALDSEGRALLTQHKIRTWEGKEKTLTLINVYCPHADPGRPERLVFKMRFYRLLQIRAEALLAAGSHVIILGDLNTAHRPIDHWDAVNLECFEEDPGRKWMDSLLSNLGCQSASHVGPFIDSYRCFQPKQEGAFTCWSAVTGARHLNYGSRLDYVLGDRTLVIDTFQASFLLPEVMGSDHCPVGAVLSVSSVPAKQCPPLCTRFLPEFAGTQLKILRFLVPLEQSPVLEQSTLQHNNQTRVQTCQNKAQVRSTRPQPSQVGSSRGQKNLKSYFQPSPSCPQASPDIELPSLPLMSALMTPKTPEEKAVAKVVKGQAKTSEAKDEKELRTSFWKSVLAGPLRTPLCGGHREPCVMRTVKKPGPNLGRRFYMCARPRGPPTDPSSRCNFFLWSRPS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006281 (DNA repair), GO:0006284 (base-excision repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0001650 (fibrillar center), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Dual specificity protein kinase KNS1 (EC 2.7.12.1) (P32350)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Nonessential protein kinase.
InterPro domains:
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [305-721]
- IPR051175: Dual specificity CLK kinases (family) [226-721]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [436-448]
- IPR017441: Protein kinase, ATP binding site (binding_site) [319-343]
- IPR000719: Protein kinase domain (domain) [313-720]
Sequence:
MSQNIQIGTRKRSRANMNNSTTTGPANNTSSNKTFLDNFEETRTNKLLDEMFARQNSFLTDNLRNSLDLNQADNPLRPRQHQHQLFLDNENAIELDEEPRIINTTINNSNNHNSSRVDEDADDDIIFIKEQPIQFSSPLILPSSSSINNNNNIVTSNNPGCGTAATSNSTYITTPKKFKKQRTISLPQLPLSKLSYQSNYFNVPDQTNAIVPRVTQTENELLHLTGSCAKTLEGNKAVNLTIAHSTSPFSNPPAQIASLPQSNLKKQIGSSLRKFTSNGSSESASSNKSNFKTDKDGHYVYQENDIFGSGGRFVVKDLLGQGTFGKVLKCIDNKYEPNYVAVKVIRAVDRYREAAKTELRILQTILNNDPQGQFQCLLLRECFDYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAIARQLIRSVCFLHDLGIIHTDLKPENILICDETHIAQKLPLKTVQSLSKRRREASKGKRKILKNPEIKIIDFGSAIFHYEYHPPVISTRHYRAPEIVLGLGWSFPCDIWSIACVLVELVIGESLYPIHENLEHMAMMQRINGTPFPTDIIDKMFYKSKHKLGNSPSDLNSTVIKHFDRKTLSLQWPEKNKRGDTITTEKSMKRVLQSCDRLDIYISKVLKQDYGDSLSINWNLPPEKNWSLINSKLAWKRQTHSSSSSTTDELDKETFLFWYWFIDLLRKMFEFDPTKRITAKDALDHEWFNLGILDDGIATYNNTQG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0006468 (protein phosphorylation), GO:0016310 (phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Defensin D1 (Ns-D1) (P86972)
Organism: Nigella sativa (Black cumin)
Function: Antimicrobial peptide active against fungi, Gram-positive and Gram-negative bacteria. Inhibits growth of hyphae in the fungi A.niger (IC(50)=3.5 ug/ml), B.sorokiniana (IC(50)=3.0 ug/ml), F.oxysporum (IC(50)=9.5 ug/ml), F.graminearum (IC(50)=6.9 ug/ml), F.culmorum (IC(50)=6.9 ug/ml) and B.cinerea (IC(50)=27.4 ug/ml). Has no effect on spore germination. Destroys spores in germinated conidia by disruption of cell walls and membranes in A.niger and B.sorokiniana. Causes vacuolization of germinated macro- and microconidia in F.oxysporum, F.graminearum and F.culmorum. Strongly inhibits growth of P.infestans on potato tubers above concentrations of 13.6 ug/ml. Inhibits growth of Gram-positive bacteria C.michiganensis and B.subtilis and of Gram-negative bacteria P.syringae, E.carotovora and E.coli.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P69241}.
InterPro domains:
- IPR036574: Knottin, scorpion toxin-like superfamily (homologous_superfamily) [1-50]
- IPR008176: Defensin, plant (family) [1-24]
- IPR003614: Knottin, scorpion toxin-like (domain) [2-50]
Sequence:
KFCEKPSGTWSGVCGNSGACKDQCIRLEGAKHGSCNYKPPAHRCICYYEC
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0090729 (toxin activity), GO:0016247 (channel regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0016248 (channel inhibitor activity), GO:0099106 (ion channel regulator activity), GO:0008200 (ion channel inhibitor activity), GO:0017080 (sodium channel regulator activity), GO:0019871 (sodium channel inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0001906 (cell killing), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0031640 (killing of cells of another organism), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0009620 (response to fungus), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0050832 (defense response to fungus), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium), GO:0050830 (defense response to Gram-positive bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Cytochrome P450 like protein (Cytochrome P450, family 77, subfamily B, polypeptide 1) (F25C20.25 protein) (Putative cytochrome P450) (Q9SAB7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
InterPro domains:
- IPR001128: Cytochrome P450 (family) [36-499]
- IPR002401: Cytochrome P450, E-class, group I (family) [66-478]
- IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [29-510]
- IPR017972: Cytochrome P450, conserved site (conserved_site) [448-457]
Sequence:
MDLTDVIIFLFALYFINLWWRRYFSAGSSQCSLNIPPGPKGWPLVGNLLQVIFQRRHFVFLMRDLRKKYGPIFTMQMGQRTMIIITDEKLIHEALVQRGPTFASRPPDSPIRLMFSVGKCAINSAEYGSLWRTLRRNFVTELVTAPRVKQCSWIRSWAMQNHMKRIKTENVEKGFVEVMSQCRLTICSILICLCFGAKISEEKIKNIENVLKDVMLITSPTLPDFLPVFTPLFRRQVREARELRKTQLECLVPLIRNRRKFVDAKENPNEEMVSPIGAAYVDSLFRLNLIERGGELGDEEIVTLCSEIVSAGTDTSATTLEWALFHLVTDQNIQEKLYEEVVGVVGKNGVVEEDDVAKMPYLEAIVKETLRRHPPGHFLLSHAAVKDTELGGYDIPAGAYVEIYTAWVTENPDIWSDPGKFRPERFLTGGDGVDADWTGTRGVTMLPFGAGRRICPAWSLGILHINLMLARMIHSFKWIPVPDSPPDPTETYAFTVVMKNSLKAQIRSRT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006790 (sulfur compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006082 (organic acid metabolic process), GO:0019757 (glycosinolate metabolic process), GO:0042430 (indole-containing compound metabolic process), GO:0019760 (glucosinolate metabolic process), GO:0016143 (S-glycoside metabolic process), GO:1901657 (glycosyl compound metabolic process), GO:0043436 (oxoacid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)
Protein: GIM5A protein (Q9N9D0)
Organism: Trypanosoma brucei brucei
Function: Not known
Subcellular location: Peroxisome membrane {ECO:0000256|ARBA:ARBA00046271}.
InterPro domains:
- IPR008733: Peroxisomal biogenesis factor 11 (family) [13-193]
Sequence:
MSAQAHTYLCDAWNRDKVMAIVQFLPMALEGPARTAGCESLALSLGNLARMGDAYRAVTRLSLLANALSKPTLTSLSKPTGDMVASRIDQLSHLFHIGFCLNENTAVLAGHGVFPKSLHRLSGVAVLCWMYTLVLGIVRQLYLFVKLRPRQASRGAGAGDDKKVPAYTYLELKRAFVNLLKLVCYFLFALTCLPEGKPQLLANASGPLVPLHVMVKALSPNPLHASNTVRGLLGLIASVCEFY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0007031 (peroxisome organization), GO:0048285 (organelle fission), GO:0016559 (peroxisome fission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0042579 (microbody), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome), GO:0098588 (bounding membrane of organelle), GO:0031903 (microbody membrane), GO:0020015 (glycosome), GO:0005778 (peroxisomal membrane)
Protein: CDPK-related kinase 3 (AtCRK3) (EC 2.7.11.1) (Calcium/calmodulin-dependent protein kinase 4) (AtCK) (Q9ZUZ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger (By similarity). Serine/threonine kinase that phosphorylates histone H3 an GLN1-1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16472779}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
InterPro domains:
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [134-421]
- IPR050205: Calcium-dependent Serine/Threonine Protein Kinases (family) [127-568]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [267-279]
- IPR011992: EF-hand domain pair (homologous_superfamily) [432-584]
- IPR002048: EF-hand domain (domain) [446-481]
- IPR017441: Protein kinase, ATP binding site (binding_site) [149-175]
- IPR000719: Protein kinase domain (domain) [143-405]
Sequence:
MGQCYGKVNQSKQNGEEEANTTTYVVSGDGNQIQPLTPVNYGRAKNTPARSSNPSPWPSPFPHGSASPLPSGVSPSPARTSTPRRFFRRPFPPPSPAKHIKASLIKRLGVKPKEGPIPEERGTEPEQSLDKSFGYGKNFGAKYELGKEVGRGHFGHTCSGRGKKGDIKDHPIAVKIISKAKMTTAIAIEDVRREVKLLKSLSGHKYLIKYYDACEDANNVYIVMELCDGGELLDRILARGGKYPEDDAKAIVVQILTVVSFCHLQGVVHRDLKPENFLFTSSREDSDLKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSLEADIWSIGVITYILLCGSRPFWARTESGIFRTVLRTEPNYDDVPWPSCSSEGKDFVKRLLNKDYRKRMSAVQALTHPWLRDDSRVIPLDILIYKLVKAYLHATPLRRAALKALAKALTENELVYLRAQFMLLGPNKDGSVSLENFKTALMQNATDAMRESRVPEILHTMESLAYRKMYFEEFCAAAISIHQLEAVDAWEEIATAGFQHFETEGNRVITIEELARELNVGASAYGHLRDWVRSSDGKLSYLGFTKFLHGVTLRAAHARPR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016310 (phosphorylation), GO:0006468 (protein phosphorylation), GO:0046777 (protein autophosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0055044 (symplast), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0009506 (plasmodesma), GO:0070161 (anchoring junction), GO:0005886 (plasma membrane), GO:0005911 (cell-cell junction)
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q380U6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
InterPro domains:
- IPR025932: Trypanosome variant surface glycoprotein, B-type, N-terminal domain (domain) [10-368]
- IPR019609: Trypanosome variant surface glycoprotein, C-terminal (domain) [410-508]
Sequence:
MTPQATALLALALTAEQARGNIPAGANEQEFGALCAIVDLSRSDITINQFPDQTAALEGAVLALNMSLADESWQKRFSKDGAKKEWIKELPAGTADPGHWKKSWPKWAAAAARLADQGTAAEIKSSGFETLNPIERAGAKASVAQIAAEAQFLTQQIAEKENVGKKHTAATVKAALNEAIYGVKQEAPPDFEPTRNYDGLNTQAREAICVGLGSEAKTTTIAGAIYCICGQDNAQAEKVCARNQADTHKWTSITNAMTKDGFEEIVKHCAGPAKTHLTSSLLMGLITKIKNLIRRVGANAYMGALKTGSSCNGDKTQGICIKYAGYDGTPTKDFAAIPWAQKLLALHDDLRQQEKAIAEATALEQQLAVAKNKAYAAALLQKTAPPTAGQTSSDNVNRKGDQGTQPTNKCNQIVTEETCNKENECSYEKESDGTKRCKYNATKATANGVPVTQPQKGPAKTTENKCKWKPEKDFKSPDCKWDGKECKNSSIIANKQFAMIVSAFVAMVF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0052200 (response to host defenses), GO:0052572 (response to host immune response), GO:0042783 (evasion of host immune response), GO:0020033 (antigenic variation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)