lokahq/bioreason-rl huggingface dataset:
Protein: Carboxylesterase (Q9HXE7)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
InterPro domains:
- IPR003140: Phospholipase/carboxylesterase/thioesterase (domain) [12-213]
- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [1-215]
- IPR050565: Acyl-protein thioesterase 1-2/Carboxylesterase-like (family) [11-215]
Sequence:
MSEPLILDAPNADACIIWLHGLGADRTDFKPVAEALQMVLPSTRFILPQAPSQAVTVNGGWVMPSWYDILAFSPARAIDEDQLNASADQVIALIDEQRAKGIAAERIILAGFSQGGAVVLHTAFRRYAQPLGGVLALSTYAPTFDDLALDERHKRIPVLHLHGSQDDVVDPALGRAAHDALQAQGVEVGWHDYPMGHEVSLEEIHDIGAWLRKRL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0052689 (carboxylic ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0036211 (protein modification process), GO:0009057 (macromolecule catabolic process), GO:0043412 (macromolecule modification), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0098732 (macromolecule deacylation), GO:0042159 (lipoprotein catabolic process), GO:0035601 (protein deacylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Complement C2 (A0A8J8XKZ6)
Organism: Rattus norvegicus (Rat)
Function: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase
Subcellular location: Secreted
InterPro domains:
- IPR002035: von Willebrand factor, type A (domain) [245-383]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [389-676]
- IPR011360: Complement B/C2 (family) [35-681]
- IPR035976: Sushi/SCR/CCP superfamily (homologous_superfamily) [37-228]
- IPR001254: Serine proteases, trypsin domain (domain) [395-675]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [210-392]
- IPR018114: Serine proteases, trypsin family, histidine active site (active_site) [434-439]
- IPR000436: Sushi/SCR/CCP domain (domain) [38-228]
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [393-683]
- IPR001314: Peptidase S1A, chymotrypsin family (family) [424-617]
- IPR033116: Serine proteases, trypsin family, serine active site (active_site) [606-617]
Sequence:
MTFSLPWLSRSTVLETMAPLLALLALLQLGPGLAALSCPQNVNIVGGNFTLSRGWAPGSVLIYSCPLGRYPSPAWRECQSNGQWQTPRASSLPTLRSSRLAKAVCKPVRCPAPTSFENGIYIPRLGSYPVGGNLSFECEHGFTLRGSPVRYCRPNGVWDGETAVCDNGASHCPNPGISVGTMRTGSSFDLGDKVSYRCSSTNLVLTGSVERECLSNGVWSGSEPICRQPYSYDFPEDVASALGTSFTHLLGATNPIQKRTENLGRKIQIQRSGHLNLYLLLDASQSVSEKDFNIFKESAFLMVDRIFSFEIKVSVAIITFASRPKIIMSVLNERSQNVMEVMDSLDSVCYKDHENATGTNTYEALNSVYLMMNNQMDRLGMETSAWQEIRHAIILLTDGKSNMGGSPKPAVDNIREILGISRNRNDYLDIYAIGVGKLDVDWKELNELGSKKDGERHAFILQDAKAVQQVFEHILDVSKLTDTICGVGNMSVNASDQERTPWQVTFKPKSKETCQGSLISDQWVLTAAHCFHDAQMEDRHLWRVIVGDPTSHHGKEFHVEEVLVAPGFNVHAKQSQGISEFYADDIALLKLSQRVKMSSHARPICLPCTVGANMALRRSPGSTCKDHETELLSQQKVPAHFVALNGNRMNINLRTGPERTSCIEAVSQNKGSFPGLTNVSEVVTDQFLCSGMEGDDSPCKGESGGAVFLERRYRFFQVGLVSWGLFDPCHGSSNKNLRRKPPHGVVPRDFHISLFRLQPWLRQHLDGVLDFLPL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0007584 (response to nutrient), GO:0009991 (response to extracellular stimulus), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: LOC687713 protein (B5DFC7)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR018616: Protein GUCD1 (family) [6-238]
Sequence:
MRTEVEAAGQPLEPEDFVQLPVPTIQQLYHWDCGLACSRMVLRYLGQLDDREFENALQELQLTRSIWTIDLAYLMRHFGVRHRFCTQTLGVDKGYKNQSFYRKHFDTEETRVNQLFAQAKACKVQVEKCTVSVQDIQAHLAQGHVAIVLVNSGVLHCELCSSPVKYCCFTPRGHRCFCRAPDYQGHFIVLRGYNRATGCIFYNNPAYADRMCSTSISNFEEARTSYGTDEDILFVYLDS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:1901700 (response to oxygen-containing compound), GO:1901698 (response to nitrogen compound), GO:0031099 (regeneration), GO:0010033 (response to organic substance), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0031100 (animal organ regeneration), GO:0046683 (response to organophosphorus), GO:0051591 (response to cAMP), GO:0014070 (response to organic cyclic compound), GO:0010243 (response to organonitrogen compound), GO:0061008 (hepaticobiliary system development), GO:0097421 (liver regeneration), GO:0014074 (response to purine-containing compound), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Hemoglobin alpha, adult chain 2 (A0A0A0MP82)
Organism: Rattus norvegicus (Rat)
Function: Involved in oxygen transport from the lung to the various peripheral tissues
InterPro domains:
- IPR050056: Hemoglobin and related oxygen transporters (family) [34-144]
- IPR012292: Globin/Protoglobin (homologous_superfamily) [14-144]
- IPR000971: Globin (domain) [7-144]
- IPR009050: Globin-like superfamily (homologous_superfamily) [35-144]
- IPR002338: Hemoglobin, alpha-type (family) [35-144]
Sequence:
MVLSADDKTNIKNCWGKIGGHGGEYGEEALQRMFAAFPTTKTYFSHIDVSPGSAQVKAHGKKIGGHGGEYGEEALQRMFAAFPTTKTYFSHIDVSPGSAQVKAHGKKVADALAKAADHVEDLPGALSTLSDLHAHKLRVDPVNFKFLSHCLLVTLACHHPGDFTPAMHASLDKFLASVSTVLTSKYR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0033218 (amide binding), GO:0005515 (protein binding), GO:0042277 (peptide binding), GO:0005102 (signaling receptor binding), GO:0001540 (amyloid-beta binding), GO:0001664 (G protein-coupled receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0032355 (response to estradiol), GO:0033993 (response to lipid), GO:0014070 (response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0045202 (synapse)
Protein: Lysophosphatidic acid receptor 2b (A0A8M2BIF4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell surface. Endosome
InterPro domains:
- IPR002277: Lysophosphatidic acid receptor EDG-2 (family) [19-303]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [45-289]
- IPR004065: Lysophosphatidic acid receptor (family) [3-310]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [30-304]
Sequence:
MVCYNNETVVFFYSISHKNISDTWGTKAKAVVGMGLLVSVFVIFTNILVMAAIFMNRRFHYPIYYLLGNLAAADLFAGTSYMYLMFHTGPWTAKLTTYQWFVRQGLIDTSLTASVFNLMAIALERHQTIFTMQLHSKMTNHRVVLLILGIWTVAIIMGLVPAMGWNCMCDIGNCSTMAPLYSRSYLVFWAAINLLTFTVMVAVYTRIFIYVRRKSQRMSQHTSQVKHKETVVNLMKTVVMILGCFVVCWTPGMVLLLLDGLCHSCDVLTYEKFFLVLAESNSLMNPIIYSYRDKDMRDTFKRILCLCCRSKQSEEHSGVRFNTLEQERRRRVQQESYLARRARDAGAQQENGGRLVLQENKEMLESSDS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0002682 (regulation of immune system process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051239 (regulation of multicellular organismal process), GO:0009653 (anatomical structure morphogenesis), GO:0051093 (negative regulation of developmental process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0045595 (regulation of cell differentiation), GO:1903706 (regulation of hemopoiesis), GO:2000026 (regulation of multicellular organismal development), GO:0001568 (blood vessel development), GO:0045596 (negative regulation of cell differentiation), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0045637 (regulation of myeloid cell differentiation), GO:0045638 (negative regulation of myeloid cell differentiation), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0060284 (regulation of cell development), GO:0045646 (regulation of erythrocyte differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: G-protein coupled receptor 12 (E7FFG5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [67-316]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [67-308]
- IPR000723: G protein-coupled receptor 3/6/12 orphan (family) [52-320]
- IPR000599: G protein-coupled receptor 12 (family) [27-288]
Sequence:
MSEEVSVSPSWLAQEPTWGSSGAGSIENITVGTYSPAVILPARPPTELLVNPWDIVLCSSGTLIACENALVVLVIWQNPALRAPMFLLIGSLALADLLAGLGLVLHFTFAYLLRSDSAQLLTVGLVVASFSASVFSLLAITIDRYLSLYYALTYNSERTAAFTYTMLVLLWGVSLCLGLLPVTGVNCLGQEVNCSVVWPLTKNNVAVLSVSFLLLFGLMLQLYVQICKIVMRHAHQIALQHHFLAASPHYVTTRKGVSTLAIILGTFAACWMPFTVYSLIADYTYPPLYTYATLVPATYNSVINPVIYAFRNQEIQKALWLVCCGCIPASVAHRARTPSDV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0051716 (cellular response to stimulus), GO:0048878 (chemical homeostasis), GO:0050793 (regulation of developmental process), GO:0051239 (regulation of multicellular organismal process), GO:0044237 (cellular metabolic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0051240 (positive regulation of multicellular organismal process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0050801 (monoatomic ion homeostasis), GO:1904018 (positive regulation of vasculature development), GO:2000026 (regulation of multicellular organismal development), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045766 (positive regulation of angiogenesis), GO:0045765 (regulation of angiogenesis), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055074 (calcium ion homeostasis), GO:0006874 (intracellular calcium ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0051480 (regulation of cytosolic calcium ion concentration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Large ribosomal subunit protein eL22 (Q32Q51)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell
Subcellular location: Cytoplasm
InterPro domains:
- IPR038526: Large ribosomal subunit protein eL22 superfamily (homologous_superfamily) [8-127]
- IPR002671: Large ribosomal subunit protein eL22 (family) [5-125]
Sequence:
MAPIKKQVTKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVSIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANTKESYELRYFQINQDEEEEDED
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis), GO:0060216 (definitive hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Dopamine D4a receptor (A0A2R8RMG6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR000929: Dopamine receptor family (family) [37-369]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [17-368]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [32-353]
- IPR002185: Dopamine D4 receptor (family) [79-212]
Sequence:
MPANLTISTHTTNYNFPALIFGILLIIIIICGNVLVCLSVYTEKALKTTTNYFIVSLAVADLLLAVLVLPLFVYAEFQDGVWSLNMTVCDGLMTMDVMLCTASIFNLCAISIDRFIAVSIPLNYNRKHVDQRQIVLLSATWILALAVASPVMFGINNVPNRDHSECKLEDNNYVIYSSVCSFFVPCPIMLLLYCGMFRGLRNWEEARKAKLRSNMEACRKLQEAAASLQPLSGLPPPLPPVIEKDITLEELDQDHYPDPDSPDPVSMLAYPGGGYNQDQNQNRQRKRAKINGRERKAMRVLPVVVGAFLFCWTPFFVVHTMRALCEDCEIPGSVTSIVTWLGYVNSAINPIIYTVFNTEFRKFFRKFLPTLPGCC
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008227 (G protein-coupled amine receptor activity), GO:0004935 (adrenergic receptor activity), GO:0004936 (alpha-adrenergic receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0045165 (cell fate commitment), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0021517 (ventral spinal cord development), GO:0001708 (cell fate specification), GO:0021510 (spinal cord development), GO:0022008 (neurogenesis), GO:0048665 (neuron fate specification), GO:0007399 (nervous system development), GO:0048663 (neuron fate commitment), GO:0021514 (ventral spinal cord interneuron differentiation), GO:0021522 (spinal cord motor neuron differentiation), GO:0007417 (central nervous system development), GO:0021515 (cell differentiation in spinal cord), GO:0030182 (neuron differentiation), GO:0021520 (spinal cord motor neuron cell fate specification), GO:0048699 (generation of neurons), GO:0021953 (central nervous system neuron differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Glycerophosphodiester phosphodiesterase domain-containing 5b (A0A8M2B4R1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Endomembrane system; Multi-pass membrane protein
InterPro domains:
- IPR030395: Glycerophosphodiester phosphodiesterase domain (domain) [228-486]
- IPR017946: PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily (homologous_superfamily) [218-487]
Sequence:
MVKHQPLQVYERQLCLSCLTGIYGCRWKRYQRSHDDTTKWECLWSLILFFTFSLLLVWFYFWWEAHNDYSEFNWFLYNRSGEWSDGTVPILATTAAGFTYIAFLMILALCHVAVGQQLNLHWVHKIGVTVALLTTIIGVISVTQMWGEEWDVVWISLQATGPFLHIGALAAVTALAWLMAGQVARAEKTRFQAMVLLLYLSVLLTLYFIPLSISSPCIMERGSLKAAPAIIGHQGAPMLAPENTLLSFNRALQRNVSGLETDVTISLDGVPFLMRDRTLRRTTNVRRVFPERQYEDASLFNWTDLSTLNAGQWFLKDDPFWTVQYMSTTERWSVGNQTVCSLEQMLKLAAKYKSSALFTVHRPPVNHPHHHDWVNLTLDTVLGSGIPQGQVMWTVDSNREMVRKVAPGFQQTSMQKLPFDTLHHNGISRLLLRYNQASEQDVRLYKENNISVSLYTVNEPWLYSLLWCSGVPSVSSEAPQVLRKLHYPLWLMTPDEYCLIWISTDLISFAVVLGIFIFQNYHMIRWRMSGMRSYNPEQIMLSAAVRRSSRDVNIMKEKLIFSEVSNGVNGDEAYSENGFNYYTN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0060560 (developmental growth involved in morphogenesis), GO:0003401 (axis elongation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Alpha-amylase (A0A8M2B5V6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [17-415]
- IPR006048: Alpha-amylase/branching enzyme, C-terminal all beta (domain) [426-508]
- IPR031319: Alpha-amylase, C-terminal domain (domain) [423-511]
- IPR006047: Glycosyl hydrolase family 13, catalytic domain (domain) [26-414]
- IPR013780: Glycosyl hydrolase, all-beta (homologous_superfamily) [420-512]
- IPR006046: Alpha amylase (family) [73-317]
Sequence:
MKLLVVAALVGLCLSQHNTNFKHNRTSIVHLFEWRWADIAKECERYLAPNGYGGVQISPPSESIVLTKPWHPWWQRYQPISYNLCSRSGTEEELKDMIARCNNVGVNIYADAVINHMCGASGGEGTHSSCGTYFNAKNEDFPSVPYSSWDFNDNKCKTANEDIENYSDIFQVRDCRLVSLLDLALEKDYVRGKVAEYMNKLIDIGVAGFRVDACKHMWPGDLSNVYSRLKTLNTTWFSPGTKPFIYQEVIDLGGEPIKASEYVSLGRVTEFKYSAKLGTVIRKWEKEKLCYLKNWGEGWGFMPSHKALVFVDNHDNQRGHGAGGASVLTFWDSRLYKIATGLMLAHPYGVTAVMSSYRWDRHFVNGKDQNDWMGPPSNADGSTKSVPINPDSTCGDNWICEHRWRQIRNMVIFRNVVNGQPLSNWWDNNNNQIAFSRGSKGFIVINNDDWDLNVTLKTGLPSGTYCDIISGDKSGNSCTGKQVTVDSDGQATFSICHTEEDPFMAIHADSKL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0016160 (amylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0071495 (cellular response to endogenous stimulus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0070887 (cellular response to chemical stimulus), GO:0043627 (response to estrogen), GO:0071310 (cellular response to organic substance), GO:0032870 (cellular response to hormone stimulus), GO:0071391 (cellular response to estrogen stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Vigilin (A0A8M2BDG6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR057778: Vigilin, N-terminal KH domain (domain) [88-154]
- IPR004087: K Homology domain (domain) [152-1192]
- IPR004088: K Homology domain, type 1 (domain) [156-1188]
- IPR036612: K Homology domain, type 1 superfamily (homologous_superfamily) [147-1200]
Sequence:
MSSVAVLTQESFNEHRSGLLPEQVKAAAGGDPSSVEDDDSLPTYKDAFPPLPEKPLPEGVQETENAWTTKIKPLKSSIITQVFHVPLEERKYKDMNQFGEGDQAKVCLDIMHKTGAHLELSMAKDQGLSIMVSGKYDAVMKARKEIVSRLQTQASATVAIPKEHHRFVIGKSGEKLQELELKTATKIQIPRPDDPSNQIKISGTKEGLEKAKHEILLISAEQDKRAVERMNIDKVFHPFITGAHGKLVGDLMQETGARINVPPPSVNKTEIVITGEKEQVALAMVKIKKLYEEKKKNATTIAVEVKKSQHKYVIGPKGNTLQEILERTGVSVEIPPLDSSSETVILRGEPARLGQALTEVYAKANSYTVSSVSAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTKDVQIVQGQIEVIVTDLVSRMDYTEISVDPKFHRHLIGKGGANINRIKELHKVSVRIPPDNEKSNLIRIEGDPQGVQEAKKELLELASRMENERTKDMIIEQRFHRAIIGQKGEKIKEIRDKFPEVIINFPDPAQKSDIVQLRGPRTEVEKCSKFMQKMVAEMVENSFSVSVPIFKQFHKNIIGKGGANIKKIREETNTKIDLPAENSNSEMIVITGKKANCEAAKNRILAIQKELANITEVEVSIPSKLHNSLIGSKGRFVRSIMEECGGVHIHFPTEGSGIDAVTIRGPAEEVEKAKKQLLSLAEEKQTKSHTVELRAKPEYHKFLIGKGGGNIRKVRDSTGARIIFPTAEDKDHELITVIGTEEAVAEAQKELEALIKSLDNIVEDFMIVDPKHHRFFVARRGQVLRDIADEYGGVIVSFPRTAAQSDKVTLKGAKDCVEAAKKRMLEMIEDLDAQVTMECVIPQKFHRSIMGPKGSRIQQITKDHNVQIKFPDREEQQQADASVQENGEANGEVKEPVDPTAPKKCDVIVLSGRKERCEAAVEALKALVPVTIAVEVPFELHRYIIGQKGSGIRKMMDEFEVNIQVPAHELQSDIISITGLASHLDRAKEGLLERVKELQAEQEDRALRSFKLTITVEPKYHPKIIGRKGAIISHIRHDHEVNIQFPEKNDENQDQITITGYEQNAIAARDAIQAIVDELEEMISEDITLDSRVHARIIGARGKGIRKIMDEFKVDVRFPQSGAADPNLVTVTGRPEHVDEAIDHLLNLEEEYMADVVENEAKMAYMKPSGSSASSMEEPRGPSKGFVVREAPWATGNEKAPDMSSSEEFPSFGAPVAAAARASPWGPKRF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0071495 (cellular response to endogenous stimulus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0070887 (cellular response to chemical stimulus), GO:0043627 (response to estrogen), GO:0071310 (cellular response to organic substance), GO:0032870 (cellular response to hormone stimulus), GO:0071391 (cellular response to estrogen stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)