Protein: GDSL esterase/lipase 1 (EC 3.1.1.-) (Extracellular lipase 1) (Q9FLN0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Confers resistance to the necrotrophic fungus Alternaria brassicicola. Possesses lipase and antimicrobial activities that directly disrupt fungal spore integrity. Triggers systemic resistance, mostly by the ethylene-dependent pathway.
Subcellular location: Secreted {ECO:0000269|PubMed:16126835}. Note=Secreted upon salicylic acid treatment. {ECO:0000269|PubMed:16126835}.
InterPro domains:
- IPR035669: GDSL lipase/esterase-like, plant (family) [37-358]
- IPR001087: GDSL lipase/esterase (family) [38-354]
- IPR036514: SGNH hydrolase superfamily (homologous_superfamily) [30-360]
- IPR044552: GDSL esterase/lipase GLIP1-5/GLL25 (family) [10-372]
- IPR008265: Lipase, GDSL, active site (active_site) [38-49]
Sequence:
MENSQLVSITFLAYTIIISIGSINCIDNNNLVTNQSALFVFGDSVFDAGNNNYIDTLSSVRSNYWPYGQTTFKSPTGRVSDGRLIPDFIAEYAWLPLIPPNLQPFNGNSQFAYGVNFASGGAGALVGTFSGLVINLRTQLNNFKKVEEMLRSKLGDAEGKRVISRAVYLFHIGLNDYQYPFTTNSSLFQSISNEKYVDYVVGNMTDVFKEVYNLGGRKFGILNTGPYDCAPASLVIDQTKIRSCFQPVTELINMHNEKLLNGLRRLNHELSGFKYALHDYHTSLSERMNDPSKYGFKEGKKACCGSGPLRGINTCGGRMGLSQSYELCENVTDYLFFDPFHLTEKANRQIAELIWSGPTNITGPYNLKALFELN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0043207 (response to external biotic stimulus), GO:0006629 (lipid metabolic process), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0006952 (defense response), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0098542 (defense response to other organism), GO:0033993 (response to lipid), GO:0009751 (response to salicylic acid), GO:0010928 (regulation of auxin mediated signaling pathway), GO:0014070 (response to organic cyclic compound), GO:0009723 (response to ethylene), GO:0070542 (response to fatty acid), GO:0009753 (response to jasmonic acid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle)