lokahq/bioreason-rl huggingface dataset:
Protein: WD repeat-containing protein 46 (O15213)
Organism: Homo sapiens (Human)
Function: Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome
Subcellular location: Nucleus, nucleolus
InterPro domains:
- IPR012952: BING4, C-terminal domain (domain) [440-518]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [195-469]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [184-473]
- IPR001680: WD40 repeat (repeat) [226-427]
- IPR040315: WD repeat-containing protein WDR46/Utp7 (family) [86-610]
Sequence:
METAPKPGKDVPPKKDKLQTKRKKPRRYWEEETVPTTAGASPGPPRNKKNRELRPQRPKNAYILKKSRISKKPQVPKKPREWKNPESQRGLSGTQDPFPGPAPVPVEVVQKFCRIDKSRKLPHSKAKTRSRLEVAEAEEEETSIKAARSELLLAEEPGFLEGEDGEDTAKICQADIVEAVDIASAAKHFDLNLRQFGPYRLNYSRTGRHLAFGGRRGHVAALDWVTKKLMCEINVMEAVRDIRFLHSEALLAVAQNRWLHIYDNQGIELHCIRRCDRVTRLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGHSNGTVSLWSPAMKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRGTYQPLSTRTLPHGAGHLAFSQRGLLVAGMGDVVNIWAGQGKASPPSLEQPYLTHRLSGPVHGLQFCPFEDVLGVGHTGGITSMLVPGAGEPNFDGLESNPYRSRKQRQEWEVKALLEKVPAELICLDPRALAEVDVISLEQGKKEQIERLGYDPQAKAPFQPKPKQKGRSSTASLVKRKRKVMDEEHRDKVRQSLQQQHHKEAKAKPTGARPSALDRFVR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044085 (cellular component biogenesis), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0042254 (ribosome biogenesis), GO:0042274 (ribosomal small subunit biogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Uncharacterized protein C24C9.04 (O13964)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
InterPro domains:
Sequence:
MDPAHHIKDTSAELLSQQDFSILQSRLLEFLASQEARETVTASKELTLLRQGIRQLKEKVSKMEPEEMTVKEKKSIIEILKARIALKKAFLKMALSESNDTVVKKEDVRESPVDTFMENAT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003712 (transcription coregulator activity), GO:0003713 (transcription coactivator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0044085 (cellular component biogenesis), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0043933 (protein-containing complex organization), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0006996 (organelle organization), GO:0010468 (regulation of gene expression), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0031326 (regulation of cellular biosynthetic process), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0065003 (protein-containing complex assembly), GO:0042254 (ribosome biogenesis), GO:2001141 (regulation of RNA biosynthetic process), GO:0022618 (ribonucleoprotein complex assembly), GO:0006355 (regulation of DNA-templated transcription), GO:0071826 (ribonucleoprotein complex subunit organization), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0042255 (ribosome assembly), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0016592 (mediator complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Uncharacterized WD repeat-containing protein C9G1.05 (O14301)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
InterPro domains:
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [26-593]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [9-593]
- IPR001680: WD40 repeat (repeat) [47-595]
Sequence:
MSSQLKSTWAPVPSTKPSQPCKIGTDFKGERIVYPANKAIIIREIEKQENCFQYNEHTAPTTVARFSPSGYYVASGDNQGNVRIWDCAGEDKILKNQVTAISGRITDLDWDGDSQRIIAVGEGKERYGHAFTADSGNSVGEIFGHSSVVNAVSLRKSRPFRAATASDDNSINFFHGTPYRFNRSLRVHSKFVYDVRYSPNDERFASAGADGKVYVFDGKTGDQVYEIDAHKGSIFSISWSPDSSQFVTSSAGYSCKIWDANTGSLIREWLSSDKKQLVGTVWPTKDLIIVVNSKGNLTYLNPSDCKVIDTIYGHQRSITAATLSPDATHFYTASYDGTVLSWDIGKQKAFPLVGESHTNQVMQMIMADDHVITIGMDDTLRVIDIKQGCFAKDNVFPTGYQPIGVCSVEDCLILVTVSDIQVLRSLTGVSTAKTIYQPSAVASHPLKSEFCVGGEDCCVYIHTLEKGELCEVAQCKDSTAPITCLAYSPDGKYLACGDASGKVVLYDANSREVITSRWAFHTGRILGMSWNAKSTHLATASLDTNIHIYSVERPMKYIAMKNAHSLGATQVEWVSENELLSTGSDAAIKVWSVTF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0051015 (actin filament binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0030029 (actin filament-based process), GO:0051014 (actin filament severing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0060187 (cell pole), GO:0032153 (cell division site), GO:0043229 (intracellular organelle), GO:0051286 (cell tip), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Medium/long-chain acyl-CoA thioesterase YigI (P0ADP2)
Organism: Escherichia coli (strain K12)
Function: Displays thioesterase activity against medium- to long-chain acyl-CoA substrates. Is involved in the thioesterase- dependent beta-oxidation pathway of (9Z,11E)-octadecadienoate (conjugated linoleic acid or CLA), along with TesB and FadM. In vitro, is active against decanoyl-CoA and palmitoyl-CoA (hexadecanoyl-CoA), but not with acetyl-, butyl- or benzoyl-CoA. Lacks general lipase or amidase activity. Likely plays an important and specific role under natural conditions in permitting the metabolism of unusual carbon sources
Subcellular location: Cytoplasm
InterPro domains:
- IPR003736: Phenylacetic acid degradation-related domain (domain) [25-153]
- IPR029069: HotDog domain superfamily (homologous_superfamily) [12-154]
- IPR006683: Thioesterase domain (domain) [58-143]
Sequence:
MSAVLTAEQALKLVGEMFVYHMPFNRALGMELERYEKEFAQLAFKNQPMMVGNWAQSILHGGVIASALDVAAGLVCVGSTLTRHETISEDELRQRLSRMGTIDLRVDYLRPGRGERFTATSSLLRAGNKVAVARVELHNEEQLYIASATATYMVG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016790 (thiolester hydrolase activity), GO:0016289 (CoA hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006633 (fatty acid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Uncharacterized protein C20H4.06c (Q9HE07)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR011666: G patch domain-containing protein, N-terminal (domain) [36-110]
Sequence:
MYANSRKRSNVDVHRHPYVVYGSPFDLEPSRINQGVPVWKQEARDERNRKRFHGAFTGGFSAGYFNTVGSKEGWQPKSWKSSRNENKSVHGMTIDDIMDEEDRADQELSKVYTSKINTIDTSIPIDDPLLREFSNRDDSIGEKMLKNLGWNGHDFVISPFQGYYDDTKLTNQAYHGIGYQADDVFQLERKPVGMAKNLRGGFGSGVLNDDGIEDQDIYDLGAPKMRYDKSINITKKVASPFTPVKHTFLSKKDRSKGKSIIKSQNCSDGLPPLPGFVVVFNLQSPFQNNWFPPPTIPEGWEPKLFTNSQGFSQKKAQTSNERLPLFAEKSETNSNGEASLPSDVNHGVKEDEGSWQLIDIETAKNAMSRKDNPYNDERAGIYEIFLKAHLMNMPRLLRDIDSRHLLEFTQTASLYRPMSKNLSMRFVSSFEASTKKESINSHSETDDSILRRPRTVVTFIPERLLCKRFNVALPYGQEKQKRKNISSIENVPIIAEIENKSIDSIDTRKLNRPQDIEEKPKAPQTLFSAIFGDD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0045292 (mRNA cis splicing, via spliceosome), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Low conductance mechanosensitive channel YnaI (P0AEB5)
Organism: Escherichia coli (strain K12)
Function: Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed
Subcellular location: Cell inner membrane; Multi-pass membrane protein
InterPro domains:
- IPR045042: Mechanosensitive ion channel protein YnaI-like (family) [40-334]
- IPR049278: Mechanosensitive ion channel MscS, C-terminal domain (domain) [237-324]
- IPR023408: Mechanosensitive ion channel MscS, beta-domain superfamily (homologous_superfamily) [179-229]
- IPR006686: Mechanosensitive ion channel MscS, conserved site (conserved_site) [194-228]
- IPR011066: Mechanosensitive ion channel MscS, C-terminal domain superfamily (homologous_superfamily) [231-335]
- IPR011014: Mechanosensitive ion channel MscS, transmembrane-2 (homologous_superfamily) [79-160]
- IPR006685: Mechanosensitive ion channel MscS (domain) [162-229]
- IPR049142: Mechanosensitive ion channel, transmembrane helices 2/3 (domain) [121-161]
- IPR010920: LSM domain superfamily (homologous_superfamily) [162-228]
Sequence:
MIAELFTNNALNLVIIFGSCAALILMSFWFRRGNRKRKGFLFHAVQFLIYTIIISAVGSIINYVIENYKLKFITPGVIDFICTSLIAVILTIKLFLLINQFEKQQIKKGRDITSARIMSRIIKITIIVVLVLLYGEHFGMSLSGLLTFGGIGGLAVGMAGKDILSNFFSGIMLYFDRPFSIGDWIRSPDRNIEGTVAEIGWRITKITTFDNRPLYVPNSLFSSISVENPGRMTNRRITTTIGLRYEDAAKVGVIVEAVREMLKNHPAIDQRQTLLVYFNQFADSSLNIMVYCFTKTTVWAEWLAAQQDVYLKIIDIVQSHGADFAFPSQTLYMDNITPPEQGR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0042802 (identical protein binding), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0008381 (mechanosensitive monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0031669 (cellular response to nutrient levels), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Uncharacterized GST-like protein YncG (P76117)
Organism: Escherichia coli (strain K12)
InterPro domains:
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [2-79]
- IPR010987: Glutathione S-transferase, C-terminal-like (domain) [86-205]
- IPR036282: Glutathione S-transferase, C-terminal domain superfamily (homologous_superfamily) [79-203]
- IPR004045: Glutathione S-transferase, N-terminal (domain) [1-82]
Sequence:
MIKVYGVPGWGSTISELMLTLADIPYQFVDVSGFDHEGASRELLKTLNPLCQVPTLALENDEIMTETAAIALMVLDRRPDLAPPVGRAERQLFQRLLVWLVANVYPTFTFADYPERWAPDAPEQLKKNVIEYRKSLYIWLNSQLTAEPYAFGEQLTLVDCYLCTMRTWGPGHEWFQDNATNISAIADAVCQLPKLQEVLKRNEII
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0004364 (glutathione transferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006979 (response to oxidative stress), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0010035 (response to inorganic substance), GO:0000302 (response to reactive oxygen species), GO:0042542 (response to hydrogen peroxide)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Zinc-regulated GTPase metalloprotein activator 1 (O74310)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase map1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of map1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of zng1 to the zinc binding site in the peptidase domain of map1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active map1
InterPro domains:
- IPR051316: Zinc-regulated GTPase metalloprotein activator (family) [55-402]
- IPR011629: Zinc chaperone CobW-like, C-terminal (domain) [307-411]
- IPR036627: CobW-like, C-terminal domain superfamily (homologous_superfamily) [290-404]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [58-268]
- IPR003495: CobW/HypB/UreG, nucleotide-binding domain (domain) [62-245]
Sequence:
MDFEIENESEIPQLVDVEEVNTQPHSETLSVPTVSSNNDIDSFEQQSDFLLVDHDSTLDPVPVTILTGFLGAGKTSLLRSILENRNGKRVAVLMNEVGDSGDLERSLMEDVGGEELYEEWVALSNGCMCCTVKDNGIKALEKIMRQKGRFDNIVIETTGIANPGPLAQTFWLDDALKSDVKLDGIVTVIDCKNIDNILKDESDIGFIQISHADCLILNKTDLISSEALSVVRQTILKINCLAKIIETTYGRLDDISEILDLDAYGNENTSNLEWSIQRSNDSNINCSTCLDVDCQHLHSLDTHSLDISTHTFKLPPLMSKEVFQQFLQWVRHTLWSCLEEGEDEEFMIYRSKGIFNKDDGSWYIFQGVREVFEIMPLSEKPRAFLEKDIHPEIILIGRNLHRISPFVVGNQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140104 (molecular carrier activity), GO:0016530 (metallochaperone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006882 (intracellular zinc ion homeostasis), GO:0055080 (monoatomic cation homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Protein-arginine N-methyltransferase (A0A1D8PGT0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
InterPro domains:
- IPR007364: Protein arginine N-methyltransferase SFM1-like (family) [2-204]
Sequence:
MKYIIEHMEEGFSEWVILEYTQIIKDIGKDNLILTSLPPSTTEKDIPKRLLELGLQWTTKECVDIDGGIDKSKVCLLDPAAETDLTPQDKSKFDYFVFGGILGSHPRIDRTGLLREKYGFSGRRLGSLQMTTDTAIRTTQRIIENGVAFEDIKFLDYPEIKYNKYESTEMPFRYVTDNEGNPILPEGMLELIKNDAEQSIDDLLIE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0016274 (protein-arginine N-methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity), GO:0016273 (arginine N-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0031589 (cell-substrate adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: Glutamate--cysteine ligase (A0A1D8PE63)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
InterPro domains:
- IPR004308: Glutamate-cysteine ligase catalytic subunit (family) [1-751]
- IPR014746: Glutamine synthetase/guanido kinase, catalytic domain (homologous_superfamily) [39-569]
Sequence:
MGLLSIGTPLSWDESKKYNNHVRTNGITQLINIFKQHGHRENDVFLWGDEVEYMLVDFDKTNKTARLSIDKDYIINDLNDPEKLLPIAEKQDVSYHPEYGRFMVEATPAKPYNGNLLXXXXXXXXXXXXXXQLCEDNLPSHIKLLTLTTFPRMGCNIFTSPPSKSNGIASQSLFLPDDIINRHARFPTLTANIRKRKGHKVAINLPIYPDKSTKLLDDTIPQNRELFDSDKEPWIGASKPGFIYMDSMGFGMGSSCLQITMQTKNISQARYLYDSLAPIAPIMLSLSAAAPIFKGFLVDQDVRWNVVSGAVDDRTFIEKGQEPYSGYHLFGGLDIDAQDKLRINNHQINQQGDLLDLYTKDGKPIQRVPKSRYDSIDNYLNDNYYDTKYFQDEYNDLNAPINEQVYQRLIDEGKLDKYMANHFAHLFIRDPLVIFSERINQDNNLENDHFENIQSTNWQTLRFKPPALYTKDTDLTTKPGWRVEFRPMEIQLTDFENAAYSSFITLLSKAILKFQPNFYIPLSKVEINMKLAHKVDSTLKDKFWFRSFELWNIDPQEFDDYGFEWFDRFINGNQQQNGHVNNNNNNDKKTKNDPIIVNGSTTTTNGTNSGSGITETNGTMLPKGCEGKTVEEINDVDDNGIDQRYTICQLINGSGKFPGFIKLVIKLIATDLVPQALNNSTTSKEQLIEELIRLRSYLYLLATRANGEIPTTAHWVRNKVLQHQDYKQDSKVSEKITFDLIDDSIKITELKDRQLIEGFLGADITEYLMGSK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0016879 (ligase activity, forming carbon-nitrogen bonds), GO:0016881 (acid-amino acid ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006749 (glutathione metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006750 (glutathione biosynthetic process), GO:0006518 (peptide metabolic process), GO:0043043 (peptide biosynthetic process), GO:0019184 (nonribosomal peptide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)