lokahq/bioreason-rl huggingface dataset:
Protein: Melanophilin (Exophilin-3) (Leaden protein) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) (Q91V27)
Organism: Mus musculus (Mouse)
Function: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
Subcellular location: Melanosome.
InterPro domains:
- IPR041282: FYVE-type zinc finger (domain) [8-125]
- IPR051745: Intracellular Transport Effector (family) [1-406]
- IPR037442: Melanophilin, FYVE-related domain (domain) [62-137]
- IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [8-133]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [1-146]
- IPR010911: Rab-binding domain (domain) [4-124]
- IPR006788: Rab effector MyRIP/Melanophilin (domain) [445-497]
Sequence:
MGKRLDLSTLTDEEAEHVWAVVQRDFDLRRREEERLQGLKGKIQKESSKRELLSDTAHLNETHCARCLQPYRLLLNSRRQCLECSLFVCKSCSHAHPEEQGWLCDPCHLARVVKIGSLEWYYQHVRARFKRFGSAKVIRSLCGRLQGGGGSEPSLEEGNGDSEQTDEDGDLDTEARDQPLNSKKKKRLLSFRDVDFEEDSDHLVQPCSQTLGLSSVPESAHSLQSLSGEPYSEDTTSLEPEGLEETGARALGCRPSPEVQPCSPLPSGEDAHAELDSPAASCKSAFGTTAMPGTDDVRGKHLPSQYLADVDTSDEDSIQGPRAASQHSKRRARTVPETQILELNKRMSAVEHLLVHLENTVLPPSAQEPTVETHPSADTEEETLRRRLEELTSNISGSSTSSEDETKPDGTFLGGSPKVCTDTGHMETQERNPRSPGNPARPTKSTDEELSEMEDRVAMTASEVQQAESEISDIESRIAALRAAGLTVKPSGKPRRKSGIPIFLPRVTEKLDRIPKTPPADPDDQAKMPKATTAVPSLLRRKYSPSSQGVDSGSFDRKSVYRGSLTQRNPNGRRGTARHIFAKPVMAQQP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0051020 (GTPase binding), GO:0017022 (myosin binding), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0051640 (organelle localization), GO:0007017 (microtubule-based process), GO:0007018 (microtubule-based movement), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0051656 (establishment of organelle localization), GO:0051647 (nucleus localization), GO:0007097 (nuclear migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0001750 (photoreceptor outer segment), GO:0036477 (somatodendritic compartment), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0030425 (dendrite), GO:0030424 (axon), GO:0097730 (non-motile cilium), GO:0005634 (nucleus), GO:0097733 (photoreceptor cell cilium), GO:0097731 (9+0 non-motile cilium)
Protein: Dihydroflavonol 4-reductase (Dihydroflavonol-4-reductase-like) (A2IBG0)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Function: Not known
InterPro domains:
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [20-338]
- IPR050425: NAD(P)-dependent dehydratase-like (family) [25-329]
- IPR001509: NAD-dependent epimerase/dehydratase (domain) [26-266]
Sequence:
MPTDNQMKDMKPNSIMGSSVTDGEIVCVTGGSGFIGSWLIKLLLERGYVVRATVRDPGNSKKVKHLLELPKAETHLTLWKADLAEEGSFDDAIQACTGVFHVATPMDFESEDPENEVIKPTINGVLSIMKACAKAKTVRRLVFTSSAGTIDVAEQQKPCYDETCWSDLEFIQAKKMTGWMYFVSKTMAEQAAWKFAKENNIDFVSIIPPLVVGPFIMQSMPPSLITALSPITGNEAHYSIIKQGQFIHLDDLCRAHIFLFENPKAEGRHICASHHATIIDLAKMLSEKYPEYNVPTKFKDVDENLKSVEFSSKKLLDLGFEFKYSLEDMFVGAVETCREKGLLPLSNEKKIKNID
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0043473 (pigmentation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Q498E0)
Organism: Rattus norvegicus (Rat)
Function: Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12930873}.
InterPro domains:
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [33-152]
- IPR013766: Thioredoxin domain (domain) [4-151]
- IPR037462: ERp19 (family) [34-150]
- IPR051099: Anterior Gradient and Thioredoxin Domain (family) [7-164]
- IPR017937: Thioredoxin, conserved site (conserved_site) [56-74]
Sequence:
MSLRFGATCLLSFSFLLLITSSDGRTGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPRDEDFSPDGGYIPRILFLDPSGKVRPEIINESGNPSYKYFYVSAEQVVQGMKEAQVRLTGDAFREKHFQDEL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0015035 (protein-disulfide reductase activity), GO:0016671 (oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor), GO:0015036 (disulfide oxidoreductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0032355 (response to estradiol), GO:0033993 (response to lipid), GO:0014070 (response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005788 (endoplasmic reticulum lumen), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen)
Protein: NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog (dNDUFAF6) (Protein severe impairment of CI with lengthened youth) (Q9VYS5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (Complex I) at early stages. Interacts with cytosolic Hsp90 to chaperone the Complex I subunit ND-42 in the cytoplasm.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:23509070}. Cytoplasm, cytosol {ECO:0000269|PubMed:23509070}.
InterPro domains:
- IPR008949: Isoprenoid synthase domain superfamily (homologous_superfamily) [51-332]
- IPR002060: Squalene/phytoene synthase (family) [61-309]
Sequence:
MRRLVRNWNCRLLFNAKSGQEIVSHAGIHQEAKTNAIPREKKVIEADKNGYGAKHCMSLVEKYDYENYLCTLLLPRELRRAAFALRAFNVEVSRSVSGHQIEPQIAKMRLKFWHDSIDKCFEPDSQRSYVEDQPVLRELKHTVGSRKLNKVYLRRLVTARERPPTHAFESIRELEEYTEQTFSSLLLLLLEVGGVRDLNADHAASHLGKAQGIATLLRSIPLAGRQQAPCIPLEVLVLHGVSQERIIRSKSDDKGVEDCIFDVASAANTHLKLARQLHDKVPPQVRKIFLSAVATDAYLERLRRANFLLTHKSCVGRDTLLPARLFWKSLLNRF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0010257 (NADH dehydrogenase complex assembly), GO:0032981 (mitochondrial respiratory chain complex I assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Slr1944 protein (P74506)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Not known
InterPro domains:
- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [189-516]
- IPR010802: Domain of unknown function DUF1400 (domain) [28-153]
Sequence:
MIDFKRLLGIALTSSLLVLASPSVIKGAETITFSIMPLGQFDISVKSLTDFAETGTIDPDFKFYTQHLKPEELEKLRGLLNHSFKFNSVEAFRFFNTTFGKEIAQQLSYIIAAPTDQSQPFLEGAIVTAAQNPDGFKIIDVINAYGGSDLVLNLDTFKNTIDQADTLYQATDRIFTWLGKQEIPSNPVPPNLKPLALAEPGPQKWTTQNLTIPRPNGQPVNVFVYLPQGNSSPAPLVVIAPGLNSNFQAFTYIADHLASYGFTIAGIDFPESDAARMQDSLQGLDAFPDPNAWLEQPKDVTLVLDTLAQKAATDPAWQGKFDINNVGILGHSLGGYTAIASGGATLEWPELLQQCEQLNKPNQINLNPALLWQCQGVGSAPPASNLRESRIKAVLAINPVTNPIFGPDGMKNLAVPTLIVAGSKDIFAPPVPEQIIPFSLIEGVNKYLLLVQNGTHLSFLEDTDNLPEKIVGPGQDLAYTYMKSLGLAFFDLYLQQDSSFKPYLTDSVVQQMSQEPLPLQLVPSLTPAQLQQAMDINN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0030258 (lipid modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0042597 (periplasmic space), GO:0030313 (cell envelope), GO:0030288 (outer membrane-bounded periplasmic space)
Protein: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC 5.3.1.16) (5-proFAR isomerase) (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase) (Q10184)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000250}.
InterPro domains:
- IPR011060: Ribulose-phosphate binding barrel (homologous_superfamily) [9-245]
- IPR044524: Histidine biosynthesis, HisA-like (family) [8-256]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [7-257]
- IPR006062: Histidine biosynthesis protein (family) [11-238]
- IPR011858: His6/HISN3 (family) [7-255]
Sequence:
MEKSQHTLFRPCIDIHQGQVKQIVGGTLGNDADVKTNYVSLKPSSYYAELYKLNHLEGAHVIMLGPNCEEAAKTALHTWPGALQIGGGINISNAQNWLQEGASKVIVTSWLFPDAQFDLDRLKAISSKIGKDRLVVDVSCRRKDNRWFAAINKWQVMTAFELNEENLDLLSQYCSEFLIHAADVEGLCKGIDEDLVIKLGEWVKIPTTYAGGGRSIEDLDLVDKLSKGKVDLTIGSALDIFGGVLEFTRVVAWNRRFTPLPLQD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016860 (intramolecular oxidoreductase activity), GO:0016861 (intramolecular oxidoreductase activity, interconverting aldoses and ketoses)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0006547 (histidine metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0000105 (histidine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Retromer subunit (A0A1D8PJS7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
InterPro domains:
- IPR028934: Vacuolar protein sorting protein 26 related (family) [1-346]
- IPR014752: Arrestin-like, C-terminal (homologous_superfamily) [1-347]
Sequence:
MSIFFKAPLDIEIRLDNEDTRKHVEVKTPQGRVEKLPIYKDGESVKGVVTLRTKEGRKLEHLGVRVQLLGSIETNTDGISSSEFLTLATELAAPAQLSHPESYPFEFKNVEKQYESYRGKNVRLRYYIKVTVLRKSSSEIIREKELWVYHYTTAVPKPVTGLSSSSTADSKLGAKKANEDTLQKPATPSSNDDASANTSKGSTISKRNESHSVKMDVGIENCLHIEFEYSRSRFSLTDAIIGKIYFLLVRLKIKHMELSLIRRETVGAPPNQVTDSETVVRFEIMDGAPVKGETIPIRLFLSGFDLVPTYRDVNKKFSTRTYLSLVLIDEDARRYFKQSEIILYRDQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0140318 (protein transporter activity), GO:0008320 (protein transmembrane transporter activity), GO:0022884 (macromolecule transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0009607 (response to biotic stimulus), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0098796 (membrane protein complex), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0030904 (retromer complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)
Protein: Amino acid ABC transporter (A0A0H2UQP0)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Not known
InterPro domains:
- IPR025134: Protein of unknown function DUF4059 (family) [5-76]
Sequence:
MREIMLLQLFSLYFESLILTTILVLIFLGIWIGLRAMSGVDKTARARQAHLYDMIMIGVLVVPVLSFAVMSLILVFKA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport), GO:0006605 (protein targeting)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: CSN8/PSMD8/EIF3K domain-containing protein (Q4Q557)
Organism: Leishmania major
Function: Not known
InterPro domains:
- IPR016024: Armadillo-type fold (homologous_superfamily) [9-108]
- IPR009374: Eukaryotic translation initiation factor 3 subunit K (family) [8-204]
- IPR033464: CSN8/PSMD8/EIF3K (domain) [44-154]
- IPR016020: Translation initiation factor 3, subunit 12, N-terminal, eukaryotic (homologous_superfamily) [6-100]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [106-208]
Sequence:
MTRDDGTQVAQLLSEGKYNLPMFLRYLKASSMEGDQPDKSLLLGILLQSLARFQTSDFTACMCLVPSHVQDSPSVEKELNYIYGLENLLSCGLFARFWTQWSSVKEHLPESFHFEARVRTSILETICITMESIPTEKLATYLAVSPDQVQKVVHNAMKDSEDRDMKVMAYDSGSVVFHRNRFNYPQAGAAQDAIRFTDVSSVIHNDVPRRGAAVAADETRDVRARTWARMADE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005852 (eukaryotic translation initiation factor 3 complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)
Protein: D-cysteine desulfhydrase (EC 4.4.1.15) (P76316)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine. Can also catalyze the degradation of 3-chloro-D-alanine.
InterPro domains:
- IPR005966: D-cysteine desulfhydrase (family) [12-328]
- IPR023702: D-cysteine desulphhydrase, bacterial (family) [1-328]
- IPR036052: Tryptophan synthase beta chain-like, PALP domain superfamily (homologous_superfamily) [7-326]
- IPR001926: Tryptophan synthase beta chain-like, PALP domain (domain) [16-316]
- IPR027278: 1-aminocyclopropane-1-carboxylate deaminase/D-cysteine desulfhydrase (family) [2-328]
Sequence:
MPLHNLTRFPRLEFIGAPTPLEYLPRFSDYLGREIFIKRDDVTPMAMGGNKLRKLEFLAADALREGADTLITAGAIQSNHVRQTAAVAAKLGLHCVALLENPIGTTAENYLTNGNRLLLDLFNTQIEMCDALTDPNAQLEELATRVEAQGFRPYVIPVGGSNALGALGYVESALEIAQQCEGAVNISSVVVASGSAGTHAGLAVGLEHLMPESELIGVTVSRSVADQLPKVVNLQQAIAKELELTASAEILLWDDYFAPGYGVPNDEGMEAVKLLARLEGILLDPVYTGKAMAGLIDGISQKRFKDEGPILFIHTGGAPALFAYHPHV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0016829 (lyase activity), GO:1901363 (heterocyclic compound binding), GO:0043168 (anion binding), GO:0019842 (vitamin binding), GO:0070279 (vitamin B6 binding), GO:0016846 (carbon-sulfur lyase activity), GO:0030170 (pyridoxal phosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0006790 (sulfur compound metabolic process), GO:0044248 (cellular catabolic process), GO:0006082 (organic acid metabolic process), GO:0016054 (organic acid catabolic process), GO:0044273 (sulfur compound catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0000096 (sulfur amino acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0000098 (sulfur amino acid catabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046395 (carboxylic acid catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)