Protein: Transcriptional adapter ADA2 (Q75LL6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). The exact mechanism of action is not yet known (By similarity). ADA2 and GCN5 function to acetylate nucleosomes, opening up the promoter region. The ADA2-GCN5 histone acetyltransferase (HAT) module is recruited by WOX11 to regulate crown root cell proliferation and stem cell maintenance of root meristem. The ADA2-GCN5 HAT module together with WOX11 targets and regulates a set of root-specific genes involved in carbon metabolism, cell wall biosynthesis, and auxin transport and response.
Subcellular location: Nucleus {ECO:0000269|PubMed:28487409}.
InterPro domains:
- IPR016827: Transcriptional adaptor 2 (family) [37-563]
- IPR055141: Transcriptional adapter 2-alpha/beta-like domain (domain) [275-343]
- IPR000433: Zinc finger, ZZ-type (domain) [47-104]
- IPR001005: SANT/Myb domain (domain) [107-156]
- IPR043145: Zinc finger, ZZ-type superfamily (homologous_superfamily) [44-99]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [104-556]
- IPR017930: Myb domain (domain) [111-158]
- IPR017884: SANT domain (domain) [106-158]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [485-556]
- IPR041983: ADA2-like, zinc finger, ZZ-type (domain) [51-99]
Sequence:
MGRSRGVPNSGDDETNHRSKRRRVASSGDAPDSLSAACGGAGEGGGKKALYHCNYCNKDISGKIRIKCSKCPDFDLCVECFSVGAEVTPHRSNHPYRVMDNLSFPLICPDWNADEEILLLEGIEMYGLGNWAEVAEHVGTKTKAQCIDHYTTAYMNSPCYPLPDMSHVNGKNRKELLAMAKVQGESKKVLPGDLTPKDESPFSPPRVKVEDALGEGLAGRSPSHIAGGANKKASNVGQFKDGANVAKVEDGHVDRSIGVKKPRYSADEGPSLTELSGYNSKRHEFDPEYDNDAEQALAEMEFKETDSETDRELKLRVLRIYLSRLDERKRRKEFILERNLLFPNPLEKDLTNEDKEVYHRYKVFMRFLSKEEHEALVRSVLEERKIRRRIQELQECRSAGCRTLAEAKIHIEQKRKKEHEVNAQKAKESGQLLSNTKVVHKTNRPMKIESDGNLDQKKGGASLDSTGRDSPKTTGHAGTKHWDDWDIVGFPGAELLSTSEKNLCCQNRLLPNHYLKMQEVLMQEIFKGSVAKKEDAHVLFKVDPAKVDNVYDMVTKKLGTNEEAPTV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0048583 (regulation of response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0044238 (primary metabolic process), GO:0009791 (post-embryonic development), GO:1901564 (organonitrogen compound metabolic process), GO:2000028 (regulation of photoperiodism, flowering), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0043414 (macromolecule methylation), GO:0016043 (cellular component organization), GO:0048608 (reproductive structure development), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0048367 (shoot system development), GO:0061458 (reproductive system development), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0006325 (chromatin organization), GO:0048586 (regulation of long-day photoperiodism, flowering), GO:0008213 (protein alkylation), GO:0006338 (chromatin remodeling), GO:0016571 (histone methylation), GO:0018193 (peptidyl-amino acid modification), GO:0016570 (histone modification), GO:0034968 (histone lysine methylation), GO:0031056 (regulation of histone modification), GO:0018205 (peptidyl-lysine modification), GO:0070734 (histone H3-K27 methylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)