lokahq/bioreason-rl huggingface dataset:
Protein: Putative ferric-chelate reductase 1 homolog (DmSDR2) (EC 1.-.-.-) (Q8MSU3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Putative ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
InterPro domains:
- IPR005018: DOMON domain (domain) [245-368]
- IPR002861: Reeler domain (domain) [25-195]
- IPR042307: Reeler domain superfamily (homologous_superfamily) [34-173]
- IPR051237: Ferric-chelate Reductase and Defense (family) [23-299]
- IPR006593: Cytochrome b561/ferric reductase transmembrane (domain) [372-570]
Sequence:
MMQALTMRSWLATLVTALLAVAIWPDPGQSLPQGAPETVCDTMLPFHSGGSVLPQNSVSPFSVETSSSTLGQGQTLRVDLTGVPAGLSFGGYMIQARNRNPPHQIIGQFGPARDGTIKLMNCENSVNNSATHSNAGPKQQVILEWQSPVDFLGQVVFNATIAQSYNEFWVGVPSQPVQIVRRDLSAAPPLPTQSPSAPAGTTRAPYVPPSYVAPNNVVAVSSDPIYNGCGQSKNCFGFPDGCVATKSCTSITVVTVRGDVFEFEIQSGKGTNAAYVAVGLSDDAKMGDDLTTECVPENGRVNLYSSLTSASPYSAVRSNVNQNSARLLDASIVDGVIYCRVQRDAVTNVQGRTFDLRNGKYHLLVASGSSLKENSVGYHDIGRLPSAQPINLAEVQDLSGSSRLLIQLHGAFMIAAWIGTTSLGIIFARYFKQTWVGSQSCGTDQWFAWHRLLMVTTWSLTVAAYVLIWVELKQAVWHAHSIIGLITVILCFIQPIGALFRPGPNDKKRPYFNWGHWLGGNLAHILGIVTIFFSVKLPKAELPEWMDWILVSFVVVHVLVHLIFSIGGMASERHLSQRANTFQMGDMSHHQQHAMRNGMSMERKMDAPYAGMRKGLLGVYGVVLILFVTVLILLVVLAPIEQFLGKS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016722 (oxidoreductase activity, acting on metal ions), GO:0000293 (ferric-chelate reductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055072 (iron ion homeostasis), GO:0055080 (monoatomic cation homeostasis), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0031090 (organelle membrane), GO:0098590 (plasma membrane region), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0000139 (Golgi membrane)
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q8RWN3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
InterPro domains:
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [604-934]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [744-756]
- IPR050494: Serine/threonine and dual-specificity kinase (family) [292-933]
- IPR044092: Serine/threonine-protein PRP4, catalytic domain (domain) [616-932]
- IPR000719: Protein kinase domain (domain) [617-932]
Sequence:
MANDKQIESHHRKHHRSSSSSDDTEKASKRHKHRHHKHHHHRHRHHRDKKRENEIPSAGDETEILDVTPAAPIVVSNGCEEEDVEEGEILEEDGIGDVLMKTADSDGESGEIKFEDNNLPPLGEKGRQGEEKSSNGVLTRESEREDKRWDKEAGGPSERVSKLSYDNGRSSFSPSNSRQSNEGRARSRSKSHDRERETSRSRFAEDEFSDRGRHHDSSRDYHHDRVDSVRTEERYHRRGRYEENDRQYSREVLERDRSKERDMDREGSIRDRDSEGSKRRDKDSDRRREREREKRREIESDRERRKEKERERSIDRDRRKEREGDYLRDRANERGRSRDRTRYNSRERKREKEREGEKDWERGRETQKDREKYISSDVDYGEMRHKQSRNTRYDAVDDLEMRKPNSLKAHNSKGDKLEETWANDERSRNEDGQDDNDEGLTWKSPEEEEEELLNRIKEESRKRMEAILEKHKRKPEQQNELLTQDNGKDIVPETGAPVSTSPAVVIAANVGQAKTNLDFDTVAAKAPLIAGGPPTMSGISDSEKNQAQAGLGEGSPKSERSADMFHDDIFGESPAGIRKVGGKGDGVPMVRSGLHDNWDDAEGYYSYQFGELLDGRYEVIATHGKGVFSTVVRAKDLKAGPAEPEEVAIKIIRNNETMHKAGKIEVQILKKLAGADREDRRHCVRFLSSFKYRNHLCLVFESLHLNLREVLKKFGRNIGLQLSAVRAYSKQLFIALKHLKNCGVLHCDIKPDNMLVNEGKNVLKLCDFGNAMFAGKNEVTPYLVSRFYRSPEIILGLTYDHPLDIWSVGCCLYELYSGKVLFPGATNNDMLRLHMELKGPFPKKMLRKGAFIDQHFDHDLNFYATEEDTVSGKLIKRMIVNVKPKDFGSIIKGYPGEDPKILAHFRDLLDKMFILDPERRLTVSQALAHPFITGK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Small ribosomal subunit protein eS4z (40S ribosomal protein S4-1) (Q93VH9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000250}.
InterPro domains:
- IPR038237: Small ribosomal subunit protein eS4, central domain superfamily (homologous_superfamily) [122-172]
- IPR000876: Small ribosomal subunit protein eS4 (family) [1-255]
- IPR032277: Small ribosomal subunit protein eS4, C-terminal domain (domain) [212-258]
- IPR018199: Small ribosomal subunit protein eS4, N-terminal, conserved site (conserved_site) [8-22]
- IPR013843: Small ribosomal subunit protein eS4, N-terminal (domain) [3-38]
- IPR014722: Large ribosomal subunit protein uL2, domain 2 (homologous_superfamily) [175-245]
- IPR041982: Small ribosomal subunit protein eS4, KOW domain (domain) [175-229]
- IPR013845: Small ribosomal subunit protein eS4, central region (domain) [95-169]
- IPR036986: RNA-binding S4 domain superfamily (homologous_superfamily) [1-117]
- IPR005824: KOW (domain) [174-210]
Sequence:
MARGLKKHLKRLNAPKHWMLDKLGGAFAPKPSSGPHKSRECLPLVLIIRNRLKYALTYREVISILMQRHIQVDGKVRTDKTYPAGFMDVVSIPKTNENFRLLYDTKGRFRLHSIKDEEAKFKLCKVRSIQFGQKGIPYLNTYDGRTIRYPDPLIKPNDTIKLDLEENKIVEFIKFDVGNVVMVTGGRNRGRVGVIKNREKHKGSFETIHIQDSTGHEFATRLGNVYTIGKGTKPWVSLPKGKGIKLTIIEEARKRLSAQQA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0009266 (response to temperature stimulus), GO:0009409 (response to cold)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0044391 (ribosomal subunit), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043228 (non-membrane-bounded organelle), GO:0022627 (cytosolic small ribosomal subunit), GO:0015935 (small ribosomal subunit), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005840 (ribosome), GO:0005634 (nucleus)
Protein: Flagellar biosynthesis protein FlhF (Flagella-associated GTP-binding protein) (Q44758)
Organism: Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) (Borrelia burgdorferi)
Function: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
InterPro domains:
- IPR020006: Flagellar biosynthesis protein FlhF (family) [5-264]
- IPR000897: Signal recognition particle, SRP54 subunit, GTPase domain (domain) [174-369]
- IPR003593: AAA+ ATPase domain (domain) [173-356]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [169-357]
- IPR047040: Flagellar biosynthesis protein FlhF, GTPase domain (domain) [175-367]
Sequence:
MVQYFTEKGPTYNEVIEIIKKKYGKNARVMTYKTVPHGGILGLFSKDWVEVSGYVRYDIGNQQINVEDEKRKILQSIKREENSSIEDVLKEVKSLKTELAHKKENINHPTITKIEDILRENDFSENYIKDINEFIKREFSLSDLDDYERVREDVVLYIAKTIKCSGSIIDNLKKRVFILVGPTGVGKTTTIAKLAAIYGINGESKSLNIKIITIDNYRIGAKKQIQTYGDIMGIPVRAIESFKDLKDEITDSKDFDLILVDTIGKSPKDFMKLAEMKELLNACGRDAEFHLAVSSTTKTSDVKEIFHQFSPFNYKTVIFTKVDETTCVGNLISLIYEMKKVVSYVTDGQIVPHNISVAEPLTFIRRINGYRISDDAEFIKKIKSKSYY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0097367 (carbohydrate derivative binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0032555 (purine ribonucleotide binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0017076 (purine nucleotide binding), GO:0016462 (pyrophosphatase activity), GO:0005525 (GTP binding), GO:0019001 (guanyl nucleotide binding), GO:0032561 (guanyl ribonucleotide binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006970 (response to osmotic stress), GO:0001101 (response to acid chemical), GO:0009266 (response to temperature stimulus), GO:1901700 (response to oxygen-containing compound), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0009409 (response to cold), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0009651 (response to salt stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Ribonuclease H2 subunit B (Ribonuclease HI subunit B) (A0A2R8Y6M7)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
InterPro domains:
- IPR041195: Rnh202, triple barrel domain (domain) [5-62]
- IPR019024: Ribonuclease H2 subunit B, wHTH domain (domain) [65-198]
- IPR040456: Ribonuclease H2 subunit B (family) [2-244]
Sequence:
MKNGLMFVKLVNPCSGEGAIYLFNMCLQQLFEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHVTEEKGNPEIDNKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNVSSRVQSTAFFSGDQASTDKEEDYIRYAHGLISDYIPKELSDDLSKYLKLPEPSASLPNPPSKKIKLSDEPVEAKEDYTKFNTKDLKTEKLGLPTGHFVMAAQRQKRGK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0006325 (chromatin organization), GO:0008104 (protein localization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0071824 (protein-DNA complex subunit organization), GO:0033365 (protein localization to organelle), GO:0006334 (nucleosome assembly), GO:0051276 (chromosome organization), GO:0065004 (protein-DNA complex assembly), GO:0034502 (protein localization to chromosome), GO:0034728 (nucleosome organization), GO:0065004 (protein-DNA complex assembly), GO:0034508 (centromere complex assembly), GO:0071459 (protein localization to chromosome, centromeric region), GO:1903083 (protein localization to condensed chromosome), GO:0034501 (protein localization to kinetochore)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Max-like protein 1 (G5EEH5)
Organism: Caenorhabditis elegans
Function: Transcriptional regulator which binds to the E box motif 5'-CACGTG-3', when in a heterodimeric complex with mdl-1. Involved in the control of lifespan in response to dietary restriction, the decline in protein homeostasis associated with normal aging and may overlap with the insulin-like signaling pathway. Involved in promoting infection by the microsporidian pathogen N.parisii.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
InterPro domains:
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [29-88]
- IPR002418: Transcription regulator Myc (family) [22-78]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [25-114]
Sequence:
MSDMSDLEDDQTGHCGSGEHSGPFDPKRHAREQHNALERRRRDNIKDMYTSLREVVPDANGERVQASRAVILKKAIESIEKGQSDSATLSVDVAEQESKNAKLREEIARLKAKKDPSSSQSIIQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0009791 (post-embryonic development), GO:0002164 (larval development), GO:0002119 (nematode larval development), GO:0040024 (dauer larval development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Centrin, putative (Q584G1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
InterPro domains:
- IPR011992: EF-hand domain pair (homologous_superfamily) [21-178]
- IPR050230: Calmodulin/Myosin light chain/Troponin C-like (family) [31-178]
- IPR002048: EF-hand domain (domain) [35-182]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [48-172]
Sequence:
MSSSRPATGNRLAVPIRTNLPVPAPRKRRFELTDEQRQEIREAFELFDSDKNGLIDAHEMKVSMRALGFDAKKEEVLRMMQDCAARDQHNNPLMDLAGFTDLMTERFAQRDPRQEMIKAFQLFDENNTGKISLRSLRRVARELGENMTDEELQAMIDEFDTDQDGEINLDEFLAIMLEDDDY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0044085 (cellular component biogenesis), GO:0031023 (microtubule organizing center organization), GO:0032053 (ciliary basal body organization), GO:0030030 (cell projection organization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0010256 (endomembrane system organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0065003 (protein-containing complex assembly), GO:0007010 (cytoskeleton organization), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0007030 (Golgi organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0043229 (intracellular organelle), GO:0036064 (ciliary basal body), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Chromosome-anchoring protein RacA (P45870)
Organism: Bacillus subtilis (strain 168)
Function: Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12493822}. Note=Localizes to cell poles and nucleoid, in a DivIVA-dependent manner.
InterPro domains:
- IPR000551: MerR-type HTH domain (domain) [1-63]
- IPR023522: Chromosome-anchoring protein RacA (family) [1-182]
- IPR009061: Putative DNA-binding domain superfamily (homologous_superfamily) [1-119]
Sequence:
MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVKVLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQDESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIPETAAASEKTKTRKKPLLSLFKFQT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:1900190 (regulation of single-species biofilm formation), GO:0016043 (cellular component organization), GO:1900192 (positive regulation of single-species biofilm formation), GO:0044085 (cellular component biogenesis), GO:0022607 (cellular component assembly), GO:0043933 (protein-containing complex organization), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009295 (nucleoid), GO:0032153 (cell division site), GO:0005886 (plasma membrane)
Protein: ShKT domain-containing protein (Q9XVB1)
Organism: Caenorhabditis elegans
Function: Not known
InterPro domains:
- IPR003582: ShKT domain (domain) [21-156]
Sequence:
MICYAVFLIFLAQFANAQDKPCIDDPNVKCEDFKDDCATEKMIPLLKESCPVTCKLCPPTEAPTTLAPCFDDKDTDCASFKQFCSNSKYIPMLKSFCPVTCNMCPGATTVMPTPNPNCQDNGPNCAGWVKNGYCNKCFYKCSEREKYCAKSCGFCTPGTCKDCNSLETLFSFGANKLL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Small archaeal modifier protein 2 (SAMP2) (Ubiquitin-like small archaeal modifier protein 2) (D4GZE7)
Organism: Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Function: Functions as a protein modifier covalently attached to lysine residues of substrate proteins, as well as a sulfur carrier in tRNA thiolation. The protein modification process is termed sampylation and involves the formation of an isopeptide bond between the SAMP2 C-terminal glycine carboxylate and the epsilon-amino group of lysine residues on target proteins. Is able to form polymeric chains with itself at Lys-58, similar to ubiquitin and other ubiquitin-like proteins. May serve as a proteolytic signal in the cell to target proteins for degradation by proteasomes.
InterPro domains:
- IPR053833: Small archaeal modifier protein 2 (family) [1-63]
- IPR053834: Ubiquitin-like small modifier protein 2, halobacteria (family) [1-66]
- IPR016155: Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp (homologous_superfamily) [6-66]
- IPR053752: Small archaeal modifier domain-containing protein (homologous_superfamily) [1-66]
Sequence:
MNVTVEVVGEETSEVAVDDDGTYADLVRAVDLSPHEVTVLVDGRPVPEDQSVEVDRVKVLRLIKGG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0031386 (protein tag)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)