Protein: Arginine decarboxylase 1, chloroplastic (ADC 1) (ADC-O) (ARGDC 1) (AtADC1) (EC 4.1.1.19) (Q9SI64)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the biosynthesis of putrescine. Catalyzes the first step of polyamine (PA) biosynthesis to produce putrescine from arginine. Is a minor contributor to basal arginine decarboxylase (ADC) activity and putrescine biosynthesis. Accumulation of putrescine plays a positive role in freezing tolerance. Production of polyamines is essential for normal seed development. Controls PA homeostasis which is crucial for normal plant growth and development.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:28109885}. Cytoplasm, cytosol {ECO:0000269|PubMed:28109885}. Note=Localizes mainly in the chloroplast. {ECO:0000269|PubMed:28109885}.
InterPro domains:
- IPR029066: PLP-binding barrel (homologous_superfamily) [101-383]
- IPR022657: Orn/DAP/Arg decarboxylase 2, conserved site (conserved_site) [314-327]
- IPR022644: Orn/DAP/Arg decarboxylase 2, N-terminal (domain) [128-381]
- IPR002985: Arginine decarboxylase (family) [19-663]
- IPR009006: Alanine racemase/group IV decarboxylase, C-terminal (homologous_superfamily) [43-585]
- IPR000183: Ornithine/DAP/Arg decarboxylase (family) [133-576]
- IPR022653: Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site (binding_site) [133-151]
Sequence:
MPALAFVDTPIDTFSSIFTPSSVSTAVVDGSCHWSPSLSSSLYRIDGWGAPYFAANSSGNISVRPHGSNTLPHQDIDLMKVVKKVTDPSGLGLQLPLIVRFPDVLKNRLECLQSAFDYAIQSQGYDSHYQGVYPVKCNQDRFIIEDIVEFGSGFRFGLEAGSKPEILLAMSCLCKGNPEAFLVCNGFKDSEYISLALFGRKLELNTVIVLEQEEELDLVIDLSQKMNVRPVIGLRAKLRTKHSGHFGSTSGEKGKFGLTTVQILRVVRKLSQVGMLDCLQLLHFHIGSQIPSTALLSDGVAEAAQLYCELVRLGAHMKVIDIGGGLGIDYDGSKSGESDLSVAYSLEEYAAAVVASVRFVCDQKSVKHPVICSESGRAIVSHHSVLIFEAVSAGQQHETPTDHQFMLEGYSEEVRGDYENLYGAAMRGDRESCLLYVDQLKQRCVEGFKEGSLGIEQLAGVDGLCEWVIKAIGASDPVLTYHVNLSVFTSIPDFWGIDQLFPIVPIHKLDQRPAARGILSDLTCDSDGKINKFIGGESSLPLHEMDNNGCSGGRYYLGMFLGGAYEEALGGVHNLFGGPSVVRVLQSDGPHGFAVTRAVMGQSSADVLRAMQHEPELMFQTLKHRAEEPRNNNNKACGDKGNDKLVVASCLAKSFNNMPYLSMETSTNALTAAVNNLGVYYCDEAAAGGGGKGKDENWSYFG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0042802 (identical protein binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity), GO:0016831 (carboxy-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0009266 (response to temperature stimulus), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0009611 (response to wounding), GO:0006979 (response to oxidative stress), GO:0006970 (response to osmotic stress), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0034641 (cellular nitrogen compound metabolic process), GO:0009409 (response to cold), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1901566 (organonitrogen compound biosynthetic process), GO:0097305 (response to alcohol), GO:0033993 (response to lipid), GO:0009308 (amine metabolic process), GO:0009651 (response to salt stress), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0009737 (response to abscisic acid), GO:0070542 (response to fatty acid), GO:0009753 (response to jasmonic acid), GO:0006576 (biogenic amine metabolic process), GO:0009309 (amine biosynthetic process), GO:0042401 (biogenic amine biosynthetic process), GO:0006595 (polyamine metabolic process), GO:0009445 (putrescine metabolic process), GO:0006596 (polyamine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)