Protein: NADPH--cytochrome P450 reductase 3 (CPR) (P450R) (EC 1.6.2.4) (Q653S9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes (By similarity). It can also provide electron transfer to heme oxygenase and cytochrome B5 (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03212, ECO:0000269|PubMed:23053415}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03212}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03212}.
InterPro domains:
- IPR023208: NADPH-cytochrome P450 reductase (family) [15-714]
- IPR023173: NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily (homologous_superfamily) [357-490]
- IPR017938: Riboflavin synthase-like beta-barrel (homologous_superfamily) [283-556]
- IPR001094: Flavodoxin-like (domain) [106-239]
- IPR001433: Oxidoreductase FAD/NAD(P)-binding (domain) [568-678]
- IPR017927: FAD-binding domain, ferredoxin reductase-type (domain) [311-559]
- IPR001709: Flavoprotein pyridine nucleotide cytochrome reductase (domain) [347-671]
- IPR029039: Flavoprotein-like superfamily (homologous_superfamily) [84-275]
- IPR039261: Ferredoxin-NADP reductase (FNR), nucleotide-binding domain (homologous_superfamily) [555-714]
- IPR003097: Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding (domain) [309-531]
- IPR008254: Flavodoxin/nitric oxide synthase (domain) [105-255]
Sequence:
MDSGGGGGGGALRPSALDLVAALLTGRGRPEEEGWPPSLAENRHLIVLLTTSLAVLVGCGVALLVRRSSISAPAVRAQEPQPRAPAPAKRKQEAEPDPDDGRQRVAVFFGTQTGTAEGFAKALAEEAKSRYDKAVFKVLDLDEYAADDEEYEQKLKKEIIALFFVATYGDGEPTDNAARFYKWFGEGNERGEWLSNLRFGVFGLGNRQYEHFNKVGKVVDQLLAEQGGKRIVPLGLGDDDQCIEDDFNAWKELLWPELDKLLRVEDDKSAAPTPYTAAIPEYRVVLVKPEEAMHINKSFSLSNGHAVYDIQHPCRANVAVRRELHTPASYRSCIHLEFDISGTGLTYETGDHVGVYAENCTETVEEVENLLGYSPDTLFSIHADQEDGTPLFGGSLPPPFPSPCTVGTALARYADLLSFPKKSALIALASHASDPKDAERLRHLASPAGKKEYSQWIVSSQRSLLEVMTEFPSAKPPLGVFFAAIAPRLQPRYYSISSSPRMTPTRIHVTCALVYGQTPTGRIHKGVCSTWMKNSIPLEESQECSWAPIFVRQSNFKLPTDPTVPIIMIGPGTGLAPFRGFLQERLALKETGVELGHAVLFFGCRNRKMDFIYEDELNNFVETGALSELIVAFSREGPSKEYVQHKMAEKAPEIWSIISQGGYIYVCGDAKGMARDVHRTLHTIVQEQGSLDNSNTESYVKSLQMEGRYLRDVW
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0016653 (oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0030258 (lipid modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)