Protein: Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (Decapentaplegic and Vg-related 1 RNA-binding protein) (IGF-II mRNA-binding protein 3) (VICKZ family member 3) (Vg1 RNA-binding protein) (Vg1-RBP) (Q9PW80)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Involved in neuronal crest migration.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10525193}. Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250|UniProtKB:O00425}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:O00425}. Note=Accumulates along the vegetal cortex as oogenesis progresses. Colocalizes to extended processes in migrating neuronal crest cells.
InterPro domains:
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [2-156]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [1-155]
- IPR036612: K Homology domain, type 1 superfamily (homologous_superfamily) [186-567]
- IPR004087: K Homology domain (domain) [193-561]
- IPR000504: RNA recognition motif domain (domain) [2-156]
- IPR004088: K Homology domain, type 1 (domain) [197-558]
Sequence:
MNKLYIGNVSEQASALDLESIFEQWKIPFSAPFLVKSGYAFVDCPDEKVAMRAIDTLSGKVELHGKVLEVEHSVPKRQRSCKLQIRNIPPHMQWEVLDGLLAQYGTVESCEQVNTDTETAVVNVRYGAKDQAREAMDKLNGFLMENYALKVSYIPDETAAADAPAVGGRRGFNPRGPPRQGSPSLGARPKLQSDVPLRLLVPTQFVGAIIGKEGATIRNITKQTHSKIDIHRKENAGAAEKPITVHSTPEGCSSACRNIMEIMQKEAIDTKITEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQDLTLYNPERTITVKGTLDACAKAEEEIMKKVRESYENDVAAMHLQSNLIPGLNLNALGLFPGAASGGISPSVVSGPPPGAQAGYQSFGAQMESETVHLFIPALAVGAIIGKQGQHIKQLSRFAGASIKIAPADGIDAKQRMVIISGPPEAQFKAQGRIFGKLKEENFFGPKEEVKLEAHIKVPSFAAGRVIGKGGKTVNELQNLTSAEVVVPRDQTPDENDQVVVKITGHFYASQLAQRKIQEIISQVRRQQQPKPSAAGPPVARRK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0003407 (neural retina development), GO:0060041 (retina development in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1990904 (ribonucleoprotein complex)