lokahq/bioreason-rl huggingface dataset:
Protein: Homeobox protein SIX5 (Q8N196)
Organism: Homo sapiens (Human)
Function: Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity)
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR001356: Homeodomain (domain) [201-263]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [199-259]
- IPR017970: Homeobox, conserved site (conserved_site) [234-257]
- IPR031701: Homeobox protein SIX1, N-terminal SD domain (domain) [86-196]
Sequence:
MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVALQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEAEAKVLTQLQSVPVEEPLEL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Trace amine-associated receptor 13c (Q5QNP2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Olfactory receptor for medium length odd-chained diamines including cadaverine which is generated by bacterial decarboxylation of the basic amino acid lysine and contributes to the odor of decomposing tissue. Mediates pronounced innate aversion behavior to cadaverine
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR050569: Trace Amine-Associated Receptor (family) [19-325]
- IPR009132: Trace amine associated receptor family (family) [56-292]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [34-323]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [49-309]
Sequence:
MDLSSQEYDPSQFCFPAVNNSCLKGTHHVSTQTVVYLILASAMTVTVLGNSVVIISIAHFKQLQTPTNILVMSLALADLLLGLVVMPFSMIRSVDGCWYYGETFCLLHTGFDLFLTSVSIFHLIFIAVDRHQAVCFPLQYPTRITIPVAWVMVMISWSMAAFYSYGVVYSKANLEGLEEYIASVYCMGGCTLYFNALWSVLDTLLTFFLPCSVMVGLYARIFVVAKKHIKSITEANQNENENVFKNPRRSERKAAKTLGIVVGAFILCWLPFFINSLVDPYINFSTPYALFDAFGWLGYTNSTLNPIIYGLFYPWFRKTLSLIVTLRIFEPNSSDINLFTV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008227 (G protein-coupled amine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0042445 (hormone metabolic process), GO:0050793 (regulation of developmental process), GO:0051239 (regulation of multicellular organismal process), GO:0044237 (cellular metabolic process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0040014 (regulation of multicellular organism growth), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0048638 (regulation of developmental growth), GO:0033554 (cellular response to stress), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0010570 (regulation of filamentous growth), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: HTH-type transcriptional regulator TreR (P36673)
Organism: Escherichia coli (strain K12)
Function: Repressor of the treBC operon. It is able to bind trehalose- 6-phosphate and trehalose
InterPro domains:
- IPR010982: Lambda repressor-like, DNA-binding domain superfamily (homologous_superfamily) [1-61]
- IPR000843: LacI-type HTH domain (domain) [4-74]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [63-314]
- IPR012771: Trehalose operon repressor (family) [4-314]
- IPR046335: Transcriptional regulator LacI/GalR-like, sensor domain (domain) [168-313]
Sequence:
MQNRLTIKDIARLSGVGKSTVSRVLNNESGVSQLTRERVEAVMNQHGFSPSRSARAMRGQSDKVVAIIVTRLDSLSENLAVQTMLPAFYEQGYDPIMMESQFSPQLVAEHLGVLKRRNIDGVVLFGFTGITEEMLAHWQSSLVLLARDAKGFASVCYDDEGAIKILMQRLYDQGHRNISYLGVPHSDVTTGKRRHEAYLAFCKAHKLHPVAALPGLAMKQGYENVAKVITPETTALLCATDTLALGASKYLQEQRIDTLQLASVGNTPLMKFLHPEIVTVDPGYAEAGRQAACQLIAQVTGRSEPQQIIIPATLS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0032993 (protein-DNA complex)
Protein: Tetraspanin-18B (A0A8M2B5N2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May regulate angiogenesis through KDR/VEGFR2 and NOTCH1 pathways
Subcellular location: Membrane; Multi-pass membrane protein
InterPro domains:
- IPR018503: Tetraspanin, conserved site (conserved_site) [74-96]
- IPR008952: Tetraspanin, EC2 domain superfamily (homologous_superfamily) [121-227]
- IPR000301: Tetraspanin, animals (family) [15-257]
- IPR018499: Tetraspanin/Peripherin (family) [21-255]
Sequence:
MGLGEASARGTSMEGDCLSCIKYLMFVFNFLIFLGGSFLLGVGVWVVVDPTGFREIVAANPLLFTGVYIILAMGGMLFLLGFLGCCGAIRENKCLLLFFFMLILIIFLAELAAAILAFIFREHLTREYFTKELKKHYQGYNNTDVFTSTWNAIMNTFDCCGVNSPEDFEESIFRIINPSEMVPEACCRRNNHVGESGFSNREECLSGSMLYRNNKGCYSAVVDYFEMYIYVAGALAIVVLTIELFAMVFAMCLFRGIQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050793 (regulation of developmental process), GO:0051239 (regulation of multicellular organismal process), GO:2000026 (regulation of multicellular organismal development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:1901342 (regulation of vasculature development), GO:0045765 (regulation of angiogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: UTP--glucose-1-phosphate uridylyltransferase (Q59KI0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Plays a central role as a glucosyl donor in cellular metabolic pathways
Subcellular location: Secreted, cell wall. Note=Localizes to yeast but not hyphal cell surface
InterPro domains:
- IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [14-474]
- IPR006141: Intein N-terminal splicing region (ptm) [119-258]
- IPR002618: UDPGP family (family) [53-465]
- IPR016267: UTP--glucose-1-phosphate uridylyltransferase (family) [9-500]
Sequence:
MATTGKRHAKSQSTYAFDNTATNVTASQMRNALNNLADTVENPEQTTRFENEMDNFFTLFRRYLTEKASGSTLDWDKIRSPSSDEVVEYGDLNSANNSANLSKLAVLKLNGGLGTSMGCVGPKSVIEVRDGNNFLDLAVRQIEHLNRKYDADVPLLLMNSFNTDADTEKIIKKYQSHRIRVKTFNQSRFPRIYKDSLLPVPESFDDSLEAWYPPGHGDLFEALVQSGELDALLAQGREILFVSNGDNLGATVDSKILDHMIETGAEYIMELTPKTRADVKGGTLINYQGEVRLLEIAQVPKEHVEEFKSIKKFKYFNTNNLWINLRAIKKLVEANAIEVEIIPNQKTISHGKSDINVLQLETAVGAAIRHFKGAHGVVVPRSRFLPVKTCSDLLLVKSDLFYLEHGALVLDPTRDGFSNPLIKLGSHFKKVSGFQSRIPYIPKILELDHLTITGNVTIGKGVQLKGTVIIVCNDGDKIDIPNGAILENVVVTGNLTILEH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016779 (nucleotidyltransferase activity), GO:0070569 (uridylyltransferase activity), GO:0051748 (UTP-monosaccharide-1-phosphate uridylyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0009225 (nucleotide-sugar metabolic process), GO:0006011 (UDP-glucose metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: Ubiquinol-cytochrome c reductase complex assembly factor 4 (Q6RUT7)
Organism: Mus musculus (Mouse)
Function: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein
InterPro domains:
- IPR029160: Ubiquinol-cytochrome-c reductase complex assembly factor 4 (family) [1-136]
- IPR023248: Ubiquinol-cytochrome-c reductase complex assembly factor 4, vertebrates (family) [47-109]
Sequence:
MNSVLCSRAAGAVRALRLVGWASRSLHPPPRGRSPAQPADREEEDDDPNLPIQFSGSKATPIRWTVEHSLGKPQQRPWWKVLPLTLTLVALVVWCYQREESGMDLWLRQVLEEEDEEEPEGPPEELEAPALYGART
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0010257 (NADH dehydrogenase complex assembly), GO:0032981 (mitochondrial respiratory chain complex I assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Ubiquinol-cytochrome c reductase complex assembly factor 5 (Q9W3T5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion
InterPro domains:
- IPR028183: Ubiquinol-cytochrome-c reductase complex assembly factor 5 (family) [4-75]
Sequence:
MSPYSGSVRRLLDSWPGKKRFGVYRFLPLFFLLGAGLEFSMINWTVGETNFYRTFKRRQAKNYVEEQQHLQARAANNTN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0043021 (ribonucleoprotein complex binding), GO:0043022 (ribosome binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0017004 (cytochrome complex assembly), GO:0008535 (respiratory chain complex IV assembly), GO:0033617 (mitochondrial cytochrome c oxidase assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Ubiquinol-cytochrome c reductase complex assembly factor 5 (Q8C1Q6)
Organism: Mus musculus (Mouse)
Function: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation. Mediates early complex III biogenesis. Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand. Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity)
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein
InterPro domains:
- IPR028183: Ubiquinol-cytochrome-c reductase complex assembly factor 5 (family) [1-80]
Sequence:
MFSRAQVRRALQRVPGKQRFGIYRFLPFFFVLGGAMEWIMIKVRVGQETFYDVYRRKASERQYQRRLEDTSETNLHKLIK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0043021 (ribonucleoprotein complex binding), GO:0043022 (ribosome binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0017004 (cytochrome complex assembly), GO:0008535 (respiratory chain complex IV assembly), GO:0033617 (mitochondrial cytochrome c oxidase assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Ubiquinol-cytochrome c reductase complex assembly factor 6 (B7Z0X7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion
InterPro domains:
- IPR027858: Protein BRAWNIN (family) [1-55]
Sequence:
MPAGVSWGQYLKFLGCALASMMAGSQAVHLYYKPLEDLRVYIEQEQHSTQVDPTAKPPESA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0017004 (cytochrome complex assembly), GO:0008535 (respiratory chain complex IV assembly), GO:0033617 (mitochondrial cytochrome c oxidase assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Thrombin-like enzyme agkihpin-2 (N0A5N4)
Organism: Gloydius halys (Chinese water mocassin) (Agkistrodon halys)
Function: Thrombin-like enzyme that shows fibrinogenolytic activity against bovine fibrinogen alpha and beta chains, but not gamma chain. Hydrolyzes fibrin. Enhances ADP-induced human platelet aggregation. Has arginine esterase activity for TAMe (tosyl-arginine methyl ester) substrate. Reduces thrombin-induced thrombosis. Does not have hemorrhagic activity. Reduces the motility of human liver cancer HepG2 cells in a wound-healing assay
Subcellular location: Secreted
InterPro domains:
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [2-235]
- IPR001254: Serine proteases, trypsin domain (domain) [1-228]
- IPR018114: Serine proteases, trypsin family, histidine active site (active_site) [38-43]
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [10-224]
- IPR001314: Peptidase S1A, chymotrypsin family (family) [28-188]
- IPR033116: Serine proteases, trypsin family, serine active site (active_site) [177-188]
Sequence:
MILGDDECNINEHRFLVALYTSRTLFCGGTLINQEWVLTAAHCNMEDIQIKLGMHSKKVPNEDEQKRVPKEKFFCLSSKNYTLWDKDIMLIRLDSPVKNSAHIAPLSLPSSPPSVGSVCRTMGWGRISSTKETYPDVPHCVNINLLEYEMCRAPYPEFELPATSRTLCAGILEGGKDTCVGDSGGPLICNGQFQGIASWGDDPCAQPHKPAAYTKVFDHLDWIENIIAGNTDASCPP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0090729 (toxin activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0017171 (serine hydrolase activity), GO:0008233 (peptidase activity), GO:0008236 (serine-type peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0035821 (modulation of process of another organism), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006952 (defense response), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0051604 (protein maturation), GO:0006954 (inflammatory response), GO:0010467 (gene expression), GO:0002526 (acute inflammatory response), GO:0072376 (protein activation cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)