Protein: Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) (GABAAR subunit beta-3) (P63079)
Organism: Rattus norvegicus (Rat)
Function: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA- gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta3/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Plays an important role in somatosensation and in the production of antinociception (By similarity).
Subcellular location: Postsynaptic cell membrane {ECO:0000269|PubMed:9464994}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P28472}. Cell membrane {ECO:0000269|PubMed:2540033, ECO:0000269|PubMed:2548852, ECO:0000269|PubMed:9092594, ECO:0000269|PubMed:9464994}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P28472}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:25172774}. Note=The beta-3 subunits are present in Golgi synapses and on the extrasynaptic membranes (when coassembled with alpha-1/6 and gamma-2 subunits), and in some of the mossy fiber to granule cell synapses (when coassembled with alpha-6 and gamma-2 subunits) (PubMed:9464994). The beta-3 subunits, when coassembled with alpha-6 and delta subunits, are found only on the extrasynaptic somatic and dendritic membranes (PubMed:9464994). {ECO:0000269|PubMed:9464994}.
InterPro domains:
- IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [241-473]
- IPR006201: Neurotransmitter-gated ion-channel (family) [12-471]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [23-242]
- IPR006028: Gamma-aminobutyric acid A receptor/Glycine receptor alpha (family) [246-471]
- IPR018000: Neurotransmitter-gated ion-channel, conserved site (conserved_site) [161-175]
- IPR002289: Gamma-aminobutyric-acid A receptor, beta subunit (family) [96-453]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [243-472]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [250-468]
- IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [39-242]
Sequence:
MWGFAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSEINRVDAHGNILLAPMDVHNEMNEVAGSVGDTRNSAISFDNSGIQYRKQSMPKEGHGRYMGDRSIPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0060089 (molecular transducer activity), GO:0005515 (protein binding), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015108 (chloride transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0016917 (GABA receptor activity), GO:0015267 (channel activity), GO:0004890 (GABA-A receptor activity), GO:0022839 (monoatomic ion gated channel activity), GO:0005253 (monoatomic anion channel activity), GO:0022836 (gated channel activity), GO:0005254 (chloride channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0099507 (ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity), GO:0005237 (inhibitory extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048511 (rhythmic process), GO:0050896 (response to stimulus), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0042698 (ovulation cycle), GO:0009719 (response to endogenous stimulus), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0032504 (multicellular organism reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007154 (cell communication), GO:1901698 (response to nitrogen compound), GO:0007214 (gamma-aminobutyric acid signaling pathway), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0070887 (cellular response to chemical stimulus), GO:0048731 (system development), GO:0006810 (transport), GO:0009636 (response to toxic substance), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0071417 (cellular response to organonitrogen compound), GO:0022008 (neurogenesis), GO:0010243 (response to organonitrogen compound), GO:1901654 (response to ketone), GO:0007399 (nervous system development), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0048545 (response to steroid hormone), GO:1901699 (cellular response to nitrogen compound), GO:0007417 (central nervous system development), GO:0014070 (response to organic cyclic compound), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0006821 (chloride transport), GO:0032570 (response to progesterone), GO:0048699 (generation of neurons), GO:0021953 (central nervous system neuron differentiation), GO:0006820 (monoatomic anion transport), GO:0071407 (cellular response to organic cyclic compound), GO:0021954 (central nervous system neuron development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0005829 (cytosol), GO:0048786 (presynaptic active zone), GO:0043235 (receptor complex), GO:0098793 (presynapse), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0045211 (postsynaptic membrane), GO:0042734 (presynaptic membrane), GO:0048787 (presynaptic active zone membrane), GO:0098590 (plasma membrane region), GO:0045202 (synapse), GO:1902710 (GABA receptor complex), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0097060 (synaptic membrane), GO:0099634 (postsynaptic specialization membrane), GO:0098982 (GABA-ergic synapse), GO:0098978 (glutamatergic synapse)