lokahq/bioreason-rl huggingface dataset:
Protein: Succinate dehydrogenase assembly factor (F4KBT8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
InterPro domains:
- IPR036714: Flavinator of succinate dehydrogenase superfamily (homologous_superfamily) [70-171]
- IPR005631: Flavinator of succinate dehydrogenase (family) [74-156]
Sequence:
MATRKALINVHRIIRSTAVVGRSSIIPAAANRSYPIIFRNGVDLGARFFCENTASAQNFDIDLSNEENKRRTINRLLYRSKQRGFLELDLVLGNWVEENVNSMDENGVKSLIHVLNLVESEATKLLENPDLWKWLTEQEQPPEAVSSNPVFSALHEKVMKNLNKHAAPETRAAAGQPWVRGWDDFKRGRDAPISGNQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0009611 (response to wounding), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1901700 (response to oxygen-containing compound), GO:0033993 (response to lipid), GO:0097305 (response to alcohol), GO:0009737 (response to abscisic acid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Acyl carrier protein 1, chloroplastic (ACP-1) (P11829)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Subcellular location: Plastid, chloroplast.
InterPro domains:
- IPR044813: Acyl carrier protein, chloroplastic (family) [1-136]
- IPR036736: ACP-like superfamily (homologous_superfamily) [56-137]
- IPR003231: Acyl carrier protein (family) [57-133]
- IPR009081: Phosphopantetheine binding ACP domain (domain) [58-133]
- IPR006162: Phosphopantetheine attachment site (ptm) [88-103]
Sequence:
MATQFSASVSLQTSCLATTRISFQKPALISNHGKTNLSFNLRRSIPSRRLSVSCAAKQETIEKVSAIVKKQLSLTPDKKVVAETKFADLGADSLDTVEIVMGLEEEFNIQMAEEKAQKIATVEQAAELIEELINEKK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140104 (molecular carrier activity), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009628 (response to abiotic stimulus), GO:0006970 (response to osmotic stress), GO:0009651 (response to salt stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009532 (plastid stroma), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009570 (chloroplast stroma), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: T-complex protein 11 (Q587E2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
InterPro domains:
- IPR008862: T-complex 11 (family) [23-785]
Sequence:
MSEPTTPIEPNCLTSSECVRRVAKLLEQLDAAGLRYDPAQPPAPDAVENILITDKWSCRTCGATDVSTCPHTGRPHRRYLVRIAQDILRLIGARTGQFVVRPPKMSSSMDGRSRLRSLRRVTMNPQALLLAYYYAIPSCEEVDSLVTECAQHFLVLLGHLNQYGAQGEVSGEYADALLSSTALMWREYSRRIAEGLDLSKITDRQACKDTLLNATKETYLAVAREIRISPSNECLNAFLQLLRVRLGRVAPQEDLDKLEASDQQQQRYDDDEEQAELNRHGKCSLNRTSLLQSSAPPVLLSEGNTSGSDAEAPSPVAIGPPLPPNWYIDEHGRSRPPQVTEEQRRKERFSRMEFRARKAYETVIKVPEQKDDPLKKEVIAALNDAQLGILAEQCNQQPPDLRNVPSFLNLVVEGLLNALPRRLRSRVEQEVRDVLDWRVVRRSVMGSPGNISVLTRYVMGKVAQYGAPAKSEETLSLAERISEDLEKCLPDLGTAVANAFRVMFSSIRQLHEDVAHYSLLYIAPQLRDNAVPFMREFIVECLPSVEKWESSLAFVRRYFNDERVTAWIASPVAASLTIVTESAKRLRGCLVFGLIDLLRSSGCQPNERWHDYPTECFFFEKPIVFFAANAVQECALLLLLSGTVSTIFRAKGMDSATINGILKQLHDKFRRLLSEQLTLSLLKTCVSDLMRKVLVETKPECVLTDAEVQQLNGAVEKMTDTGSTLYMTFEKRIILFIEAVLARGENDPAPLGLVTDSLKQVAALLQRALTLNWEVYRLVYDGLLSHVEQQEASA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Tax1-binding protein 3 homolog (Q09506)
Organism: Caenorhabditis elegans
Function: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
InterPro domains:
- IPR036034: PDZ superfamily (homologous_superfamily) [7-116]
- IPR001478: PDZ domain (domain) [18-117]
- IPR050614: Synaptic Scaffolding LAP/MAGUK Families (family) [37-121]
- IPR017268: Tax1-binding protein 3 (family) [1-124]
Sequence:
MTAYGHMPGEAIECLSIAVELHKQEVIDAHGQVTIRVGFKIGGGIDQDPTKAPFKYPDSGVYITNVESGSPADVAGLRKHDKILQVNGADFTMMTHDRAVKFIKQSKVLHMLVARADLPPVSLH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0018992 (germ-line sex determination), GO:0009790 (embryo development), GO:0009994 (oocyte differentiation), GO:0007283 (spermatogenesis), GO:0007292 (female gamete generation), GO:0048599 (oocyte development), GO:0048477 (oogenesis), GO:0009792 (embryo development ending in birth or egg hatching)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Legumain (EC 3.4.22.34) (Protease, cysteine 1) (G1SPJ6)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Not known
InterPro domains:
- IPR001096: Peptidase C13, legumain (family) [3-435]
- IPR046427: Legumain prodomain superfamily (homologous_superfamily) [309-434]
- IPR043577: Asparaginyl endopeptidase (family) [6-435]
- IPR048501: Legumain, prodomain (domain) [311-431]
Sequence:
MIWKVATFLSVALGIDAITVGVDSPENGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIANAKDNPTPGIVINRPNGTDVYQGVPKDYTGENVTSENFLAVLRGDAEAVKGKGSGRVLKSGPRDHVFVYFTDHGATGLLVFPNDDLHVRDLNKTIQYMHKHKKYGKMVFYIEACESGSMMDHLPDDINVYATTAANPTESSYACYYDEERGTYLGDWYSVNWMEDSDVEDLTKETLHRQYQLVKSHTNTSHVMQYGNKSIASMKLMQFQGMRHRASPPVSLPPVPHLDLTPGPDVPLEILKRKLKSRANSSQYRKLSAEMHRLQNARTILEKSVSKVVLLLADSQAEAARLLSTRSPLTKHDCYEAAVTHFRTHCFNWHSSTYEYALRYLYVLVNLCEKPYPLDRIKLSLDKVCLGYY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009268 (response to pH), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis), GO:0010447 (response to acidic pH)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005764 (lysosome)
Protein: Octaketide synthase 3 (OKS 3) (EC 2.3.1.-) (Polyketide synthase 5) (C4NF91)
Organism: Aloe arborescens (Kidachi aloe)
Function: Catalyzes the iterative condensations of 8 molecules of malonyl-CoA to produce aromatic octaketides, SEK4 and SEK4b, the products of the minimal polyketide synthase for the benzoisochromanequinone actinorhodin. May be involved in the biosynthesis of the octaketide barbaloin.
InterPro domains:
- IPR001099: Chalcone/stilbene synthase, N-terminal (domain) [18-240]
- IPR016039: Thiolase-like (homologous_superfamily) [2-404]
- IPR012328: Chalcone/stilbene synthase, C-terminal (domain) [250-403]
- IPR011141: Polyketide synthase, type III (family) [14-403]
Sequence:
MGSIAESSPLMSRENVEGIRKAQRAEGTATVMAIGTAHPPHIFPQDTYADFYFRATNSEHKVELKKKFDRICKKTMIGKRYFNYDEEFLKKYPNITSFDEPSLNDRQDICVPGVPALGKEAALKAIEEWGQPLSKITHLVFCTSCGVDMPSADFQLAKLLGLNTNVNKYCVYMQGCYAGGTVLRYAKDLAENNRGSRVLVVCAELTIIGLRGPNESHLDNAIGNSLFGDGAAALIVGADPIVGIEKPIFEIVCAKQTVIPDSEDVIHLHLREAGLMFYMSKDSPETISNNVEGCLVDIFKSVGMTPPADWNSLFWIPHPGGRAILDEVEARLKLRPEKFRATRHVLWEYGNMVSACVLYILDEMRNKSAADGLGTYGEGLEWGVLLGFGPGMTVETILLHSLPPV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:0009812 (flavonoid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0009813 (flavonoid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Sesquiterpene synthase (SaSesquiTPS1) (EC 4.2.3.-) (B5A435)
Organism: Santalum album (White sandalwood)
Function: Sesquiterpene synthase producing the monocyclic sesquiterpene alcohol germacrene D-4-ol and helminthogermacrene and minor amounts of bicyclic compounds such as alpha-bulnesene, gamma-muurolene, alpha- and beta-selinenes, when incubated with farnesyl diphosphate.
InterPro domains:
- IPR008930: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (homologous_superfamily) [25-232]
- IPR005630: Terpene synthase, metal-binding domain (domain) [263-502]
- IPR001906: Terpene synthase, N-terminal domain (domain) [28-206]
- IPR008949: Isoprenoid synthase domain superfamily (homologous_superfamily) [26-557]
- IPR050148: Terpene synthase-like (family) [17-543]
- IPR044814: Terpene cyclases, class 1, plant (family) [19-556]
- IPR036965: Terpene synthase, N-terminal domain superfamily (homologous_superfamily) [67-232]
Sequence:
MENQKVPISSVPNLKELSRPIANFPPSIWGDRFINYACEDENEQAQKERQVEELKEQVRRELAATVDKPLQQLNIIDATQRLGIAYHFENEIEESLEHIYLHTYVENNCFQGSHDLYSVALWFRLLRQDGYKVSCDVFDKFRDYEDNFKNSLMEDAKGLLELYEATHLSVHGEEMLDDALEFAKTRLESIVNHLNYPLAEQVRHALYRPLRKGLPRLEAVYFFRIYEAYDSHNKALLKLAKLDFNLLQSLHKKELSDMARWWKSLDFAAKFPFARDRLVEGYFWVLGVYFEPQYSLARKIIIKVFTMISTIDDIYDAYGTLDELELFTKAMQRWDVGSLDQLPEYMKPCYKSILDVYNEIEEEMDNQGSLFRMHYAKEVMKKLVEGYMDEAKWCHEKYVPTFEEYMPVALVTSGYTFLTTISYLGMGEIASKEAFDWLFSHPPVIEASESVCRLMDDMRSHKFEQERGHVASGIECYMKQYGVTEEEAHDEFRKQLVKAWKDINEECLRPYRVPKPLLMRILNLTRVIDVIYKNEDGYTHVKKAMKDNIASLLIDPMIV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016838 (carbon-oxygen lyase activity, acting on phosphates), GO:0010333 (terpene synthase activity), GO:0010334 (sesquiterpene synthase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0120252 (hydrocarbon metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0006720 (isoprenoid metabolic process), GO:0042214 (terpene metabolic process), GO:0120251 (hydrocarbon biosynthetic process), GO:0008299 (isoprenoid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0051761 (sesquiterpene metabolic process), GO:0046246 (terpene biosynthetic process), GO:0051762 (sesquiterpene biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Kappa-casein (E7E1P7)
Organism: Bos taurus (Bovine)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
InterPro domains:
- IPR000117: Kappa casein (family) [1-142]
Sequence:
IQYVLSRYPSYGLNYYQQKPVALINNQFLPYPYYAKPAAVRSPAQILQWQVLSNTVPAKSCQAQPTTMARHPHPHLSFMAIPPKKNQDKTEIPTINTIASGEPTSTPITEAVESTVATLEDSPEVIESPPEINTVQVTSTAV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0035375 (zymogen binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0044085 (cellular component biogenesis), GO:0016043 (cellular component organization), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0097305 (response to alcohol), GO:1901654 (response to ketone), GO:0032355 (response to estradiol), GO:0033993 (response to lipid), GO:0048545 (response to steroid hormone), GO:0043933 (protein-containing complex organization), GO:0014070 (response to organic cyclic compound), GO:0022607 (cellular component assembly), GO:0032570 (response to progesterone), GO:0065003 (protein-containing complex assembly), GO:0031960 (response to corticosteroid), GO:0051259 (protein complex oligomerization), GO:0051385 (response to mineralocorticoid), GO:0051260 (protein homooligomerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0005794 (Golgi apparatus), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0005796 (Golgi lumen)
Protein: Oligopeptide/dipeptide uptake family ABC transporter, permease protein (Q5LMM7)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}.
InterPro domains:
- IPR035906: MetI-like superfamily (homologous_superfamily) [120-349]
- IPR000515: ABC transporter type 1, transmembrane domain MetI-like (domain) [130-356]
Sequence:
MGAYILRRLLLVIPTLLGIMLVNFVLVQFVPGGPVDQAIAQLQGGGDVFESFAGQGNDAQLNSQTNAVNDSYIGARGLPPEFIKELEELYGLDKPAHERFLMMLWNYMTLDFGESYFRKIDVVDLVLEKMPVSITLGLWSTLIAYAISIPLGIRKAVRDGSRFDTWTSGLIIAAYAIPGFLFAILLLVLFAGGSYWQIFPLRGLTSDNFSDLSLLGKVLDYFWHIALPLTAYTIGAFTTLTLLTKNSFLDEIKKQYVITARAKGLSESRVLYGHVFRNAMLIVISGFPGVFLSVFLGGSLIIETIFSLDGLGRLGFEATVARDYPVMFGTLFVFGLIGLLVGILSDLTYVLVDPRIDFERREG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0042887 (amide transmembrane transporter activity), GO:1904680 (peptide transmembrane transporter activity), GO:0035673 (oligopeptide transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015833 (peptide transport), GO:0042886 (amide transport), GO:0006857 (oligopeptide transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Cell division cycle 14A (A0A2R8Y6L0)
Organism: Homo sapiens (Human)
Function: Not known
InterPro domains:
- IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [1-285]
- IPR050561: Protein Tyrosine Phosphatase (family) [27-459]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [203-265]
- IPR020422: Dual specificity protein phosphatase domain (domain) [121-278]
- IPR044506: Dual-specificity phosphatase CDC14, C-terminal (domain) [105-278]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [180-273]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [218-228]
- IPR029260: Dual specificity/tyrosine protein phosphatase, N-terminal (domain) [1-96]
Sequence:
MVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPCSCLLLVFRKPFLGSPLLSLPISHL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004722 (protein serine/threonine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0050877 (nervous system process), GO:0007600 (sensory perception), GO:0050954 (sensory perception of mechanical stimulus), GO:0007605 (sensory perception of sound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Monofunctional chorismate mutase (EC 5.4.99.5) (Q9HU05)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the Claisen rearrangement of chorismate to prephenate. The joint presence of this enzyme together with cyclohexadienyl dehydratase and aromatic aminotransferase in the periplasmic compartment comprises a complete three-step chorismate to phenylalanine pathway and accounts for the so called hidden overflow pathway to phenylalanine in P.aeruginosa, in which two possible routes for it exists, namely either via phenylpyruvate or L-arogenate.
Subcellular location: Periplasm {ECO:0000269|PubMed:11532214}.
InterPro domains:
- IPR008240: Chorismate mutase, periplasmic (family) [1-183]
- IPR036979: Chorismate mutase domain superfamily (homologous_superfamily) [21-184]
- IPR051331: Chorismate mutase-related enzymes (family) [1-116]
- IPR036263: Chorismate mutase type II superfamily (homologous_superfamily) [30-183]
- IPR002701: Chorismate mutase II, prokaryotic-type (domain) [7-104]
Sequence:
MRPSFASWGLLALLLLQGPLLQAQPLSPALQQLLSLSSQRLQLADQVAQSKAQSGKAVQDSPREEQQLQMLAGQAGSHGVGAEQVRLLFAAQIEANKLVQYRLLSRPLPDAGQAVDLERIRSRLNQLNLELLRGYAPALAELRVDDCRPRLNQALQRQVRVDRLDELHAIALSRAAGDLCHWAEL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016866 (intramolecular transferase activity), GO:0004106 (chorismate mutase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0046417 (chorismate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042597 (periplasmic space)