lokahq/bioreason-rl huggingface dataset:
Protein: Rubisco accumulation factor 1.1, chloroplastic (Q9LKR8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for assembly or stability of RuBisCO. Acts at a postchaperonin step to fold and/or assemble the large subunit (rbcL) into RuBisCO. RAF1 binds first to a rbcL dimer (rbcL(2)), leading to a rbcL(8)-RAF1(4) complex formation. In the next step, RBCS displaces RAF1, thus resulting in holoenzyme formation.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
InterPro domains:
- IPR041358: Rubisco accumulation factor 1, alpha-helical domain (domain) [145-254]
- IPR037494: Rubisco accumulation factor 1 (family) [2-434]
- IPR040781: Rubisco accumulation factor 1, helix turn helix domain (domain) [73-133]
- IPR040858: Rubisco accumulation factor 1, C-terminal (domain) [273-420]
Sequence:
MLSLTATTLSSSIFTQSKTHGFFNTRPVYRKPFTTITSALIPASNRQAPPKQQLYQPFRPPPSPIPPKFRSLDTAGKIEVLADRLGLWFEYAPLISSLYTEGFTPPSIEELTGISGVEQNSLIVGAQVRDSLVQSGAKPELIAAFDTNGAELLYEIRLLNTTQRVAAAEYIVDHGFDTKGAGDLARAIKDFPHRRGDVGLGDFDYNLPGDCLSFMLYRKSREHRSPSEIRTTLLEQALETAVTEKAKKAVLRELHGESEEERVKEEEIKIIRVPVVRLRFGEVAGASSVVVLPVCKAEEGEEKLLEAPMEFESGGEFGVVEAEKDWSRWVVLPGWDPVVAVRKGVAVSFSDDREVLPWNGKGEAIMVVIDREKKTVEADNGYYYLVVADGGMKLDRGLVLKEKGVNESLGMVVLVVRPPRDDDDEWQINDEDWD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0009657 (plastid organization), GO:0009658 (chloroplast organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: 2-amino-4-ketopentanoate thiolase beta subunit (EC 2.3.1.263) (AKP thiolase) (AKPT) (C1FW07)
Organism: Unknown prokaryotic organism
Function: Involved in the ornithine fermentation pathway. Catalyzes the thiolytic cleavage of 2-amino-4-ketopentanoate (AKP) with coenzyme A (CoA) to form acetyl-CoA and alanine. It is strictly specific for AKP.
InterPro domains:
- IPR001926: Tryptophan synthase beta chain-like, PALP domain (domain) [60-366]
- IPR050214: Cysteine synthase/Cystathionine beta-synthase (family) [60-366]
- IPR053471: 2-amino-4-ketopentanoate thiolase beta subunit (family) [6-467]
- IPR036052: Tryptophan synthase beta chain-like, PALP domain superfamily (homologous_superfamily) [23-367]
Sequence:
MAKDTSYDAVMDRRAEIMSRALGLNYDEFIISDIAFDYEGMMAKAGYSLEEVRQIQSESGVGNTPLLELRNITDLARKTSKRGFGARILIKDEAANPSGSFKDRRASVSIHHAKKLGYPGVLAATSGNYGAAVASQAAMKNLGCIIVQEVFDSRHVGQPEIIEKSRKCEAYGAEVVQLTVGPELFYVSLILLEETGYFNASLYSPFGISGVETLGYELVEQIRARYDKDPAYIVVTHAGGGNVTGTARGALKAGAKNSTIIGASVDLSGLHMASDNDFNKKSFTTGHTGFGVPFATWPDRTDVPKNAARPLRYLDRYVTVTQGEVFYVTEALAQVEGMERGPAGNTSLAAAIALARELPEDEIVVVQETEYTGAGKHPWAQLDFAKQNGIAVKRGAPKENKPGKTIVIPQNFSQITATEMDLNRMRRSYIRNALERNKVKNVTEEDIRFLAEDTKTDADFVTSVIRDLGVRL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0016829 (lyase activity), GO:0019842 (vitamin binding), GO:0046983 (protein dimerization activity), GO:0043168 (anion binding), GO:0042802 (identical protein binding), GO:0016835 (carbon-oxygen lyase activity), GO:0070279 (vitamin B6 binding), GO:0042803 (protein homodimerization activity), GO:0030170 (pyridoxal phosphate binding), GO:0016836 (hydro-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0006520 (amino acid metabolic process), GO:0006082 (organic acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0006591 (ornithine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0030430 (host cell cytoplasm), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)
Protein: Gonadotropin releasing hormone receptor 4 isoform X1 (Gonadotropin-releasing hormone receptor 4) (Gonadotropin-releasing hormone receptor GnRH-R4SHS) (A3QJZ0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
InterPro domains:
- IPR001658: Gonadotrophin-releasing hormone receptor family (family) [47-315]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [65-330]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [66-338]
Sequence:
MNDSSPTSENIMFHQLTADTLNGSCDLPTCNNNTGEAALQLPTFSMAAKVRVIITFTLCAVSAVCNLGVLWAASTNNKRKSHVRILIMNLTVADLLVTFIVMPVDAAWNITVQWLAGDLACRLLMFLKLVAMYSCAFVTVVISLDRQSAILNPLAINKAKKKNKIMLSVAWAMSVVLSVPQMFLFHNVTITVPANFTQCTTRGSFVKHWQETIYNMFTFICLFLIPLAIMICCYTRILVEISRRMTKGNISSKEVHLRRSHSNIPKARMRTLKMSIVIVTSFIVCWTPYYLLGLWYWFLPEDLEETVSHSLTHMLFIFGLFNAILDPITYGLFTIHFRKGLKRYCRSAVVLTESENNSIITGSLKCSPSPFRMKRVTQSGTGTDPKQNTSTVGEEDKKAADGKTKE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0016500 (protein-hormone receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Multifunctional fusion protein [Includes: Delta-1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase) (L-glutamate gamma-semialdehyde dehydrogenase); L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88)] (Q9VNX4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
InterPro domains:
- IPR016160: Aldehyde dehydrogenase, cysteine active site (conserved_site) [352-363]
- IPR029510: Aldehyde dehydrogenase, glutamic acid active site (conserved_site) [324-331]
- IPR015590: Aldehyde dehydrogenase domain (domain) [90-556]
- IPR050485: Proline metabolism enzyme (family) [40-573]
- IPR016161: Aldehyde/histidinol dehydrogenase (homologous_superfamily) [39-558]
- IPR016162: Aldehyde dehydrogenase, N-terminal (homologous_superfamily) [44-559]
- IPR005931: Delta-1-pyrroline-5-carboxylate dehydrogenase (family) [41-572]
- IPR016163: Aldehyde dehydrogenase, C-terminal (homologous_superfamily) [327-524]
Sequence:
MLRMMRSSSSRCSSLQQSLLKSSTRCLGSVIPDLKLKDFPIANEPILGYLKDSKERKALEQALKGTASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEKAIKTAVETQPKWDRVSIADRLKIWEKAADLMATTYRQDLNAATMLGQSKTAIQAEIDSAAELIDFIRMNAYFLKEVTKYQPISENIKVTKNSLRYRGIDGFIAAVSPFNFTAIGGNLSYTPALMGNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKFALTGAVFGQDEDFVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAGGPHYILRWTSPQSIKETFVPLRDVNYPYMCE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0006560 (proline metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Importin 1 (Q38D75)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
InterPro domains:
- IPR016024: Armadillo-type fold (homologous_superfamily) [38-915]
- IPR040122: Importin beta family (family) [46-856]
- IPR011989: Armadillo-like helical (homologous_superfamily) [35-938]
Sequence:
MRRSVVAQGFSSFFTSHLSNNYYFGDYPIAVMGSVGQAILIALASASDPDPGVRHRGEAQLLELKANPHAFFTSCAELLVDANVPVRGRQLVGFMLKNSLSHPCCVQNPGLQNSVMTQAVVDADFSIRSVACTIISCAVRDGHWPVDPVVKVLTEIITTRRGDISALHGAMRALSQIVDDCVQLLDMRRLTGAVVEAILPFLQAPVAPGREGEEVQLGALEAMAILLEQAGMEVNNVSYASLQPHALTVLESCLHNLQNPPSDRLATRCVKCLVLVLCFHEAIPDHLFHNLANLMSLMMTSVEGRGEEIRIEATEFWRGCLCFPRFATLIEPMLDSLIPVLIHSMVYSEMEIGMLQANAEDWNVPDKIDEIRPRHYQARVNDTAADEDEDGGDGDGDEVEEWNLRRVSALTLDTIAEYYGERIVFTVLTSIDDMMQPSKPWQLLEAAILALGAIMDGCFSFMTPYLKDISDRLLQLLRDPSAHFLVVSISLWTGTQIGQYFVSDAEILKNFLTCVLQRMQSPSKLVQESATAALQKIINLCDDGQLSNEVPVIVGSITQCLRGYQLKNRVLLLETLETVCDVLEEPLRSSPDSVEALMGPLGAIWSETSNDSPLIFSFFSCMSGVCRAIGPSIQPALAREVFERSYQMLLLHVQKRAEAKQLGEDPPEYEFLVTSGDLLSGLFDALGGTLEPLVEQCNPALISTVIQMTLDEDIEVRRSGFSLLGDVAKNVPVLVQQRLGDVVKSAMDNLADFSDNTSSVASNVAWCLCNLLENQMDVNGVQMLDVTNGLPQLFAAIAHILGGRSLTADMRNMVENMCVCLGYMLYTNPEVESISGCPLELFAERFCMYMRNVKDGPHTEAALKGFIGATRQKVPFVVGLLHLFFDLAISVASSSAELKGSILELLNAAKAHNPSLWQEKMLQYSEQLRVRLYHVYGIQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007049 (cell cycle), GO:0000278 (mitotic cell cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase) (Q16667)
Organism: Homo sapiens (Human)
Function: May play a role in cell cycle regulation. Dual specificity CC phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:10669749}.
InterPro domains:
- IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [23-212]
- IPR050561: Protein Tyrosine Phosphatase (family) [20-199]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [135-187]
- IPR022778: CDKN3 domain (domain) [1-168]
- IPR020422: Dual specificity protein phosphatase domain (domain) [33-201]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [101-195]
- IPR008425: Cyclin-dependent kinase inhibitor 3 (family) [1-212]
Sequence:
MKPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCGIITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSDTISPEQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLAAHLSSRDSQSRSVSR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation), GO:0035335 (peptidyl-tyrosine dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Extracellular leucine-rich repeat and fibronectin type III domain-containing 1b (Protein ELFN1) (F1Q7Y5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
InterPro domains:
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [55-259]
- IPR050541: Leucine-rich repeat and transmembrane domain-containing protein (family) [74-805]
- IPR055106: ELFN1/ELFN2, fibronectin type-III domain (domain) [322-404]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [100-195]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [207-252]
- IPR001611: Leucine-rich repeat (repeat) [102-185]
Sequence:
MTEAQMSISSGSSGHGGGMVTSALLCWAVALVFLSLTRVPVVQGDCWLIEGEKGFVWLAICSQNQPPYENIPMHINSTIVDLRLNENKIRSIHFSSLSRFGNLTYLNLTKNDISYIEDGAFSAQFNLQVLQIGFNKMRNLTEGMLRGLGRLQYLYLQANLIETVTANAFWECPAIENIDLSMNRIQQLDGATFRGLSKLTTCELYANPFSCSCELLGFLRWLVAFPNRTSERMACDTPAGFSGYSLLSQNPRMPRYRNAFHALSSVCTDDNVTPYLHGSPDGGIPTRLPDLSPCGLDDCSSGTFPEETISISPTFLDSDARPIMKLKEVTHTSAVITIQIPNPFRKMYILVLYNNSFFTDIQNLKSQREEIELQNLKSHTNYTYCVASIRNSLRFNHTCLTISTGPRTLQERVVNDSTATHYIMTILGCLFGMLIVLGVVVHCLRKRKKQDEPKSKKLEKMKRNLIEMKYGTELEQGTISQLSQKQILSAGETVQRMPYLPAASDTDQYKMQEISGTPKTTKGNYMEVRSEQPERSIRECSVPPSETSQGSVAEISTIAKEVDKVNQIINNCIDALKSDSTSFQTAKSGAVSTAEPQLVLISEHPPGKSGFLSPVYKGGYHHPLQRHHSMDAPQKRASTSSSGSLRSPRSFRSEGAYRSESKYIEKASPQDESGIITVTPAAAILRAEAERIRQYSEHRHSYPGPHHIEESIEVSGSRKSSILEPLTRSRPRELSYSQLSPQYHNLSGYSSPEYSCRPSLSLWERFKLHRKRHRDEEEYIAAGHALRRKVQFAKDEDLHDILDYWKGVSAQQKS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0048013 (ephrin receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Uncharacterized transporter C757.13 (O74923)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
InterPro domains:
- IPR011701: Major facilitator superfamily (family) [81-445]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [63-489]
- IPR020846: Major facilitator superfamily domain (domain) [77-486]
Sequence:
MSSITSRVSSRSSHELTEKKSGVTNDFKNSFEVGEVKRLPDAEGTADAVAQELLADDDFTYTAKEARRVLWKIDLVMMPVMCITYMIQYLDKTALSYAALYGMKTDTHIDGHTYSSMTTLFYAGYLVAQYPAAILMQKCRLSYFIFCNVFLWSAMVCLMAACRNGPSLLGLRFLAGIFEASITPAFINITAMWYRREEQPMRTLCWYAFNGIAQIIGSILSYGLGHIHGKVASWRYVFIVIGLMSLGWGVVFVFIPSNPSKARFLSSREKRIALERVRDNRTGLENKQFKWKHAYEAFLDPQVIMITLFTGVCMITNGIGVFSTLIIKGLGYNELHSAVLNMPLGAIEVAAMFISGVLCKVFKNGRLLIGVFMNCLTLAGCLMIWKIPDSNPYGRLVGVWFTMWVPASSALLLSLISSNVAGYTKKTVTSATVFVFYSVGNIVSPQLFKSGQTPEYIEGIQAMIVSLCIIIAIAFVLTGYYIYENKRRDRLLAEDPSLGESIKNEEFMDLTDRQQPKFRYRW
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0042887 (amide transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:1904680 (peptide transmembrane transporter activity), GO:0035673 (oligopeptide transmembrane transporter activity), GO:0071916 (dipeptide transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:1903825 (organic acid transmembrane transport), GO:0098739 (import across plasma membrane), GO:0006810 (transport), GO:0089718 (amino acid import across plasma membrane), GO:0071702 (organic substance transport), GO:0098657 (import into cell), GO:0071705 (nitrogen compound transport), GO:1905039 (carboxylic acid transmembrane transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0006835 (dicarboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2) (O14796)
Organism: Homo sapiens (Human)
Function: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244. In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation. Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse. Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).
InterPro domains:
- IPR036860: SH2 domain superfamily (homologous_superfamily) [1-104]
- IPR035049: EAT-2, SH2 domain (domain) [1-103]
- IPR000980: SH2 domain (domain) [3-101]
Sequence:
MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELETFVNSNSDYVDVLP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0035556 (intracellular signal transduction), GO:0009615 (response to virus), GO:0098542 (defense response to other organism), GO:0140546 (defense response to symbiont), GO:0051607 (defense response to virus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)
Protein: AT3G03270 protein (Adenine nucleotide alpha hydrolases-like superfamily protein) (Q8LFK2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
InterPro domains:
- IPR014729: Rossmann-like alpha/beta/alpha sandwich fold (homologous_superfamily) [3-145]
- IPR006016: UspA (domain) [5-135]
Sequence:
MGKARTVGVGMDYSPTSKLALRWAAENLLEDGDTVILIHVQPQNADHTRKILFEETGSPLIPLEEFREVNLSKQYGLAYDPEVLDVLDTLSRAKKVKVVAKVYWGDPREKLCDAVENLKLDSIVLGSRGLGSLKRPNHNGFMIIMFDHSLVGLVSLDHDQSGLINMAEMGSSKSICWIRRNQERDSRWSFSDLLLDDHPLD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0009620 (response to fungus), GO:0043207 (response to external biotic stimulus), GO:0002238 (response to molecule of fungal origin)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)