Protein: CLOCK-interacting pacemaker (CLOCK-interacting circadian protein) (Q8R0W1)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock.
Subcellular location: Nucleus {ECO:0000269|PubMed:17310242}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9C0C6}. Note=Predominantly localizes to the nucleus, where it co-localizes with CLOCK. At the G1/S boundary, partially translocated to the cytosol. {ECO:0000250|UniProtKB:Q9C0C6, ECO:0000269|PubMed:17310242}.
InterPro domains:
- IPR031602: Clock-interacting pacemaker (family) [36-431]
Sequence:
MRLLTRRAGHGAATLALRVIHMQRVPVLRLPAILDMERKIPSRESPRRLSAKPGRGTEMKKLARPLGVVAADSDKDSGFSDGSSECLSSAEQMESEDMLSALGCKREDKRRQPSKAADTALPTLPPMVVMKSVLVKQGSSSSQLQSWTVQPSFEVISAQPQLFVLHPPVPSPVSSCQTGEKKSESRNYLPILNSYTKIAPHPGKRGLNSEDRGTSGVSKKLCTERPGPSLSSSEPAKTGRVLSSPSTPAPPSSKLTEDSTLQGVPSLGAGGSPQTLQPVSSSHVAKAPSLTLASPASPVCASDSTLHGLESSSPLSPLSASYTSPLWAAEHLCRSPDIFSEQRQNKHRRFQNTLVVLHKSGLLEITLKTKELIRQNQATQAELDQLKEQTQMFIEATKSRAPQAWAKLQASLTSGSSHSGSDLDTLSDHPDV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0009653 (anatomical structure morphogenesis), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0044238 (primary metabolic process), GO:0033036 (macromolecule localization), GO:0001704 (formation of primary germ layer), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044085 (cellular component biogenesis), GO:0046907 (intracellular transport), GO:0006139 (nucleobase-containing compound metabolic process), GO:0006403 (RNA localization), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0006810 (transport), GO:0051649 (establishment of localization in cell), GO:0044249 (cellular biosynthetic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0051236 (establishment of RNA localization), GO:0043170 (macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0050658 (RNA transport), GO:1901362 (organic cyclic compound biosynthetic process), GO:0071705 (nitrogen compound transport), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0010467 (gene expression), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0022607 (cellular component assembly), GO:0015931 (nucleobase-containing compound transport), GO:0006913 (nucleocytoplasmic transport), GO:0042254 (ribosome biogenesis), GO:0016070 (RNA metabolic process), GO:0051028 (mRNA transport), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0006406 (mRNA export from nucleus), GO:0006405 (RNA export from nucleus), GO:0016071 (mRNA metabolic process), GO:0051168 (nuclear export), GO:0050657 (nucleic acid transport), GO:0006351 (DNA-templated transcription), GO:0006366 (transcription by RNA polymerase II), GO:0009299 (mRNA transcription), GO:0042789 (mRNA transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)