lokahq/bioreason-rl huggingface dataset:
Protein: Small ribosomal subunit protein mS23 (28S ribosomal protein S23, mitochondrial) (MRP-S23) (S23mt) (Q2NL27)
Organism: Bos taurus (Bovine)
Function: Not known
Subcellular location: Mitochondrion {ECO:0000269|PubMed:10938081, ECO:0000269|PubMed:24799711}.
InterPro domains:
- IPR023611: Small ribosomal subunit protein mS23, conserved domain (domain) [2-129]
- IPR019520: Small ribosomal subunit protein mS23, metazoa (family) [1-189]
Sequence:
MAGSRLETVGSIFTRTRDLIRAGVLKEKPLWFDVYNAFPPLREPVFRRPRLRYGKAKSPTQDIYYHEDQIRAKFYAAYGSGPKAFDLFNPNFKSTCQRFVEKYIELQKLGETDEEKLFVEAGKALLAEGVILRRVEKARTQQEGSQVSRKSESMGVESQTALEENPPLKEVPQAQHLESPGEESKGLSPP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0140053 (mitochondrial gene expression), GO:0043043 (peptide biosynthetic process), GO:0032543 (mitochondrial translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)
Protein: Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8) (Q5W5X9)
Organism: Homo sapiens (Human)
Function: Participates positively in the ciliary Hedgehog (Hh) signaling.
Subcellular location: Cell projection, cilium {ECO:0000250|UniProtKB:Q8CHY7}. Note=Colocalizes with EVC and IQCE at the EvC zone of primary cilia. {ECO:0000250|UniProtKB:Q8CHY7}.
InterPro domains:
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [26-424]
- IPR042621: Tetratricopeptide repeat protein TTC23/TTC23L (family) [2-436]
- IPR019734: Tetratricopeptide repeat (repeat) [87-389]
Sequence:
MQESQETHISNHLDEVVAAVSITHRKKFQNKLLQTALFQPPREKLHLCEEKAKSYSNSHEYKQAVHELVRCVALTRICYGDSHWKLAEAHVNLAQGYLQLKGLSLQAKQHAEKARQILANSIVPPYSENTDVFKFSIELFHTMGRALLSLQKFKEAAENLTKAERLSKELLQCGRIIKEEWIEIEARIRLSFAQVYQGQKKSKEALSHYQAALEYVEISKGETSRECVPILRELAGVEQALGLHDVSINHFLQAHLIILSRSPSQVEAADSAHIVAHAAVASGRHEHHDVAEQYFQESMAHLKDSEGMGRTKFLSIQDEFCHFLQMTGQKERATSILRESLEAKVEAFGDFSPEVAETYRLLGGADLAQGNHSGARKKLKKCLQIQTLLYGPQDKRTLATQQAMGMLSTAPKVASKPRQASKAKVAFCTSIPQDTLLGKARPGTTAD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:0045880 (positive regulation of smoothened signaling pathway), GO:0008589 (regulation of smoothened signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0043226 (organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0043227 (membrane-bounded organelle), GO:0005929 (cilium)
Protein: Molecular chaperone Hsp90-1 (Q6UJX4)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Not known
InterPro domains:
- IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [2-229]
- IPR001404: Heat shock protein Hsp90 family (family) [1-699]
- IPR019805: Heat shock protein Hsp90, conserved site (conserved_site) [25-34]
- IPR037196: HSP90, C-terminal domain (homologous_superfamily) [518-668]
- IPR003594: Histidine kinase/HSP90-like ATPase domain (domain) [27-182]
- IPR020568: Ribosomal protein uS5 domain 2-type superfamily (homologous_superfamily) [263-518]
- IPR020575: Heat shock protein Hsp90, N-terminal (domain) [5-206]
Sequence:
MAEAETFAFQAEINQLLSLIINTFYSNKEIFLRELISNSSDALDKIRFQSLTDKSKLDAQPELFIHIVPDKTNNTLTIIDSGVGMTKADLVNNLGTIARSGTKEFMEAIAAGADVSMIGQFGVGFYSAYLVAERVVVTTKHNDDEQYVWESQAGGSFTVTRDTSGENLGRGTKMTLFLKEDQLEYLEERRLKDLIKKHSEFISYPISLWVEKTIEKEISDDEDEEEKKDEEGKVEEVDEEKEKEEKKKKKIKEVSNEWSLVNKQKPIWMRKPEEITKEEYAAFYKSLTNDWEEHLAVKHFSVEGQLEFKAVLFIPKRAPFDLFDTKKKPNNIKLYVRRVFIMDNCEELIPEYLSFVKGIVDSEDLPLNISREMLQQNKILKVIRKNLVKKCIELFFEIAENKEDYNKFYEAFSKNLKLGIHEDSQNRSKFAELLRYHSTKSGDEMTSLKDYVTRMKEGQNDIYYITGESKKAVENSPFLEKLKKKGYEVLYMVDAIDEYSIGQLKEFEGKKLVSATKEGLKLEETEDEKKKQEELKEKFEGLCKVIKDVLGDKVEKVVVSDRVVDSPCCLVTGEYGWTANMERIMKAQALRDSSMAGYMSSKKTMEINPENAIMDELRKRADADKNDKSVKDLVLLLFETALLTSGFSLDEPNTFGNRIHRMLKLGLSIDEDGGDAEADMPALEDPEADAEGSKMEEVD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0033365 (protein localization to organelle), GO:0006605 (protein targeting), GO:0072599 (establishment of protein localization to endoplasmic reticulum), GO:0045047 (protein targeting to ER), GO:0070972 (protein localization to endoplasmic reticulum)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Rifin (Q8IM84)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
InterPro domains:
- IPR006373: Variant surface antigen Rifin (family) [1-337]
Sequence:
MKVHYINILLFAFPLNILVNTHKKPSITPHHTPKIPTTRLLCECELFEPANYDSDPQMRAVMDNFSKQTQQRFHEYDESLQSKRMQCKDKCDKEIQKIILKDKLEKQMKQELTTLETKITTDDIPTCICEKSVADKMEKGCLRCAGVFSGGVAPSVGLLGGIGVYGWKMGAPTVAMELAKQAGIEEGVKTVIAQIKGISIFNPYLESVECSKYITKLNYDNVSGLMKAVQAAIKSTGETCEANSGDIVCETIYNKVERFLPVVQAGKQATTTTTETVKNAALDTIESTATTCTTAITASIIAIVVIVLIMVIIYKILRYRRKKKMKKKLQYIKLLEE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0052200 (response to host defenses), GO:0052572 (response to host immune response), GO:0042783 (evasion of host immune response), GO:0020033 (antigenic variation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033644 (host cell membrane), GO:0020002 (host cell plasma membrane)
Protein: Regulator of G-protein signaling rgs-2 (P49808)
Organism: Caenorhabditis elegans
Function: Weakly inhibits G protein signaling in nervous system, interacting preferentially with the G(O) subfamily member goa-1. In vitro, it acts as a GTPase activator of goa-1. Rgs-1 and rgs-2 redundantly adjust signaling when worms are fed to allow rapid induction of egg-laying behavior. Modulates chemotaxis responses by regulating negatively the sensitivity to quinine in ASH sensory neurons.
InterPro domains:
- IPR044926: RGS, subdomain 2 (homologous_superfamily) [65-144]
- IPR024066: RGS, subdomain 1/3 (homologous_superfamily) [39-158]
- IPR036305: RGS domain superfamily (homologous_superfamily) [37-160]
- IPR016137: RGS domain (domain) [40-159]
Sequence:
MRLLTCDCTFMGQKHSGSVSVEKKNQENDGPPTYEIVFGWSQSFENLMKHRAGQKYFAEFLKGEYSDENILFWQACEELKREKNAEKIEEKARIIYEDFISILSPKEVSLDSRVREIVNTNMGRPSASTFDEAQNQIYTLMQRDSYPRFLASNIYKTVMGTFGIKEEAV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0007610 (behavior), GO:0042221 (response to chemical), GO:0007635 (chemosensory behavior), GO:0050877 (nervous system process), GO:0007600 (sensory perception), GO:0007606 (sensory perception of chemical stimulus), GO:0050909 (sensory perception of taste), GO:0050913 (sensory perception of bitter taste)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: C4-dicarboxylic acid transporter DauA (Dicarboxylic acid uptake system A) (P0AFR2)
Organism: Escherichia coli (strain K12)
Function: Responsible for the aerobic transport of succinate from the periplasm to the cytoplasm at acidic pH. Can transport other C4-dicarboxylic acids such as aspartate and fumarate. May also play a role in the regulation of C4-dicarboxylic acid metabolism at pH 7, via regulation of expression and/or activity of DctA. May act as a co-sensor of DcuS.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:23278959}; Multi-pass membrane protein {ECO:0000255}.
InterPro domains:
- IPR036513: STAS domain superfamily (homologous_superfamily) [442-559]
- IPR018045: Sulphate anion transporter, conserved site (conserved_site) [58-79]
- IPR011547: SLC26A/SulP transporter domain (domain) [29-411]
- IPR002645: STAS domain (domain) [449-559]
- IPR001902: SLC26A/SulP transporter (family) [18-555]
Sequence:
MNKIFSSHVMPFRALIDACWKEKYTAARFTRDLIAGITVGIIAIPLAMALAIGSGVAPQYGLYTAAVAGIVIALTGGSRFSVSGPTAAFVVILYPVSQQFGLAGLLVATLLSGIFLILMGLARFGRLIEYIPVSVTLGFTSGIGITIGTMQIKDFLGLQMAHVPEHYLQKVGALFMALPTINVGDAAIGIVTLGILVFWPRLGIRLPGHLPALLAGCAVMGIVNLLGGHVATIGSQFHYVLADGSQGNGIPQLLPQLVLPWDLPNSEFTLTWDSIRTLLPAAFSMAMLGAIESLLCAVVLDGMTGTKHKANSELVGQGLGNIIAPFFGGITATAAIARSAANVRAGATSPISAVIHSILVILALLVLAPLLSWLPLSAMAALLLMVAWNMSEAHKVVDLLRHAPKDDIIVMLLCMSLTVLFDMVIAISVGIVLASLLFMRRIARMTRLAPVVVDVPDDVLVLRVIGPLFFAAAEGLFTDLESRLEGKRIVILKWDAVPVLDAGGLDAFQRFVKRLPEGCELRVCNVEFQPLRTMARAGIQPIPGRLAFFPNRRAAMADL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901682 (sulfur compound transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015116 (sulfate transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0098739 (import across plasma membrane), GO:0006810 (transport), GO:0072530 (purine-containing compound transmembrane transport), GO:0071702 (organic substance transport), GO:0098657 (import into cell), GO:0071705 (nitrogen compound transport), GO:0015851 (nucleobase transport), GO:0006863 (purine nucleobase transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Protein ARABIDILLO 2 (Q9M224)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Promotes lateral root initiation and development, independently of auxin (IAA) and abscisis acid (ABA).
Subcellular location: Nucleus {ECO:0000269|PubMed:16434475}.
InterPro domains:
- IPR016024: Armadillo-type fold (homologous_superfamily) [367-793]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [33-300]
- IPR001810: F-box domain (domain) [37-86]
- IPR011989: Armadillo-like helical (homologous_superfamily) [355-766]
- IPR006553: Leucine-rich repeat, cysteine-containing subtype (repeat) [178-229]
- IPR000225: Armadillo (repeat) [418-757]
Sequence:
MSRRVRQRVEDNGKYKVDSPSYTVIGVEDLAPKVQQYVNWTSLPYDTVFHLFTRLNYRDRASLASTCRTWRSLGASSFLWSSLDLRAHKFDLSMAASLATRCVDLQKIRFRGVDSADAIIHLKARSLLEISGDYCRKITDATLSMIAARHEALESLQLGPDFCERITSDAIRVIAFCCPKLKKLRVSGMRDVSSEAIESLAKHCPQLSDLGFLDCLNINEEALGKVVSLRYLSVAGTSNIKWKVALENWEKLPKLIGLDVSRTTIDHIAVSRLLKSSQSLKVLCALNCPYLEEDKSYSSNRFKGKVLLAVFTDTFDELASIFADNSKKPKNIFSYWRDLIRKDKSIDEIMLWIEWIISHTLLRIAESSNSQGLNDFWLNQGATLLLSLMQSAQEDVQERAATGLATFIVVDDENASIDCGRAEAVMRDGGIRLLLELAKSWREGLQSEAAKAIANLSVNAKVAKAVAEEGGISVLADLAKSMNRLVAEEAAGGLWNLSVGEEHKNAIAQAGGVNALVDLIFRWPHGCDGVLERAAGALANLAADDKCSMEVARAGGVHALVMLARNCKYEGAQEQAARALANLAAHGDSNGNNAAVGQEAGALEALVQLTQSPHEGVKQEAAGALWNLAFDDKNRESIAAFGGVEALVALAKSSSNASTGLQERVAGALWGLSVSEANSIAIGHEGGIPPLIALVRSEAEDVHETAAGALWNLSFNPGNALRIVEEGGVVALVQLCSSSVSKMARFMAALALAYMFDGRMDEYAMIGTSLESTSKSVTLNGARTMALDQIKAFIKTFMEHQIFSTGALSSAPSMLAQVSERARIPEAGHLRCSGSEIGRFVTMLRNPCLVLRACAAFALLQFTIPESRHAMHHASLMQNAGEARGLRSAAAAASMPREAKIFMKIVLRNLEHQQAESPEGMKVSYNRI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009791 (post-embryonic development), GO:0090696 (post-embryonic plant organ development), GO:0099402 (plant organ development), GO:0048731 (system development), GO:0048364 (root development), GO:0048528 (post-embryonic root development), GO:0022622 (root system development), GO:0048527 (lateral root development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Coiled-coil domain containing 106 (K7EMI9)
Organism: Homo sapiens (Human)
Function: Not known
InterPro domains:
- IPR031591: Coiled-coil domain-containing protein 106 (family) [10-244]
Sequence:
MNDRSSRRRTKPPEAASSALALMNSVKTQLHMALERNSWLQKRIEDLEEERDFLRCQLDKFISSARMEAEDHCRMKPGPRRMEGDSRGGAGGEASDPESAASSLSGASEEGSASERRRQKQKGGASRRRFGKPKARERQRVKDADGVLCRYKKILGTFQKLKSMSRAFEHHRVDRNTVALTTPIAELLIVAPEKLAEVGEFDPSKERLLEYSRRCFLALDDETLKKVQALKKSKLLLPITYRFKR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0010467 (gene expression), GO:0018130 (heterocycle biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0016070 (RNA metabolic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0006366 (transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Damage response protein 1 (Q12091)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Not known
InterPro domains:
- IPR050577: MAPR/Neuferricin/Neudesin-like (family) [33-145]
- IPR001199: Cytochrome b5-like heme/steroid binding domain (domain) [44-145]
- IPR036400: Cytochrome b5-like heme/steroid binding domain superfamily (homologous_superfamily) [39-147]
Sequence:
MSFIKNLLFGGVKTSEDPTGLTGNGASNTNDSNKGSEPVVAGNFFPRTLSKFNGHDDEKIFIAIRGKVYDCTRGRQFYGPSGPYTNFAGHDASRGLALNSFDLDVIKDWDQPIDPLDDLTKEQIDALDEWQEHFENKYPCIGTLIPEPGVNV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0019842 (vitamin binding), GO:0005496 (steroid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:1902930 (regulation of alcohol biosynthetic process), GO:0019216 (regulation of lipid metabolic process), GO:0046890 (regulation of lipid biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019218 (regulation of steroid metabolic process), GO:0050810 (regulation of steroid biosynthetic process), GO:0106118 (regulation of sterol biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005739 (mitochondrion), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: D-galactonate dehydratase family member EGBG_01401 (C8ZZN2)
Organism: Enterococcus gallinarum (strain EG2)
Function: Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.
InterPro domains:
- IPR029065: Enolase C-terminal domain-like (domain) [181-373]
- IPR018110: Mandelate racemase/muconate lactonizing enzyme, conserved site (conserved_site) [89-114]
- IPR013341: Mandelate racemase/muconate lactonizing enzyme, N-terminal domain (domain) [19-114]
- IPR013342: Mandelate racemase/muconate lactonizing enzyme, C-terminal (domain) [132-252]
- IPR029017: Enolase-like, N-terminal (homologous_superfamily) [7-384]
- IPR034593: D-galactonate dehydratase DgoD-like (family) [6-378]
- IPR036849: Enolase-like, C-terminal domain superfamily (homologous_superfamily) [102-379]
Sequence:
MTPTIITDVKSFAIKPDRHNLVVVKVETNKGISGLGCSTFQFRPLAVKTVVDEYLRPLLMGRDANEIEDIWQVMNVNSYWRNGPITNNAISGIDMALWDIKGQLADMPLYQLLGGKARTAIPAYTHAVADNLDDLYHEIDRFLAAGYRYIRCQLGFYGGNPSQLQTPEEPISGSYFDQTDYMETTLKMFAAIKEKYGNQFQMLHDVHERLHPNQAIQFAKAAEPYQLFFLEDILPPDQSHWLTQLRSQSATPIATGELFNNPMEWQELVKNRQIDFMRAHVSQIGGITPALKLAHFCDAMGVRIAWHTPSDISPVGLAVNTHLNIHLHNAAIQETIELPANTQSVFVGSPQPKGGFFYPMEKSGIGITFDEEAAADFPVVYRPHEWTQSRTPDGTLITP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0000287 (magnesium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0005975 (carbohydrate metabolic process), GO:0016052 (carbohydrate catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009274 (peptidoglycan-based cell wall)