Protein: DExH-box ATP-dependent RNA helicase DExH16, mitochondrial (EC 3.6.4.13) (ATP-dependent RNA helicase SUV3) (AtSUV3) (Protein EMBRYO SAC DEVELOPMENT ARREST 15) (Protein POLLEN DEVELOPMENT DEFECTIVE 17) (Protein POLLEN DEVELOPMENT DEFECTIVE 26) (Protein SUPPRESSOR OF VAR 3) (Q9SMX1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates (By similarity). Required during pollen development.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8IYB8}. Mitochondrion matrix {ECO:0000269|PubMed:10570936}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:Q8IYB8}.
InterPro domains:
- IPR050699: RNA/DNA Helicase (family) [72-552]
- IPR041082: Suv3, C-terminal domain 1 (domain) [438-479]
- IPR044774: Suv3, DEXQ-box helicase domain (domain) [89-230]
- IPR022192: ATP-dependent RNA helicase SUV3, C-terminal domain (domain) [504-550]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [77-383]
- IPR001650: Helicase, C-terminal domain-like (domain) [213-399]
- IPR055206: ATP-dependent RNA helicase SUV3, DEXQ-box helicase domain (domain) [77-230]
Sequence:
MAYSVVRLRKVSALGISRVLQADKGSLWRFHFEPEFGDLLRLGVLTRNYRKNSGSPKFDFTGTGTTSKFDFTDLTCPHTWYPIARKKKRKVILHVGPTNSGKTYSALKHLEQSSSGVYCGPLRLLAWEVAKRLNKANVPCDLITGQEKDLVEGATHKAVTVEMADVTSVYDCAIIDEIQMVGCKQRGFAFTRALLGIAADELHLCGDPAVVPLVEDILKVTGDDVEVHTYERLSPLVPLKVPVSSVSSIKTGDCLVTFSRKDIYAYKKTIERAGKHLCSVVYGSLPPETRTAQATRFNDETNDFDVLVASDAIGMGLNLNISRIIFSTLQKYDGSETRDLTVSEIKQIAGRAGRFQSKFPIGEVTCLHKEDLPLLHSSLKSPSPILERAGLFPTFDLLSGYSQAHPTHGLYQILEHFVENAKLSSNYFISNVEDMMKVAAIVDELPLGLQEKYLFVVSPVDVNDEISGQGLAQFAQNFSKAGIVRLREILAPDRVKVPKTPTELKELESIHKVLDLYVWLSLRLEDSFPDREVAASQKSICNLLIEQFLEGNRLNSPARFSRYLRRQKLSE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0003006 (developmental process involved in reproduction), GO:0009791 (post-embryonic development), GO:0048316 (seed development), GO:0009790 (embryo development), GO:0048608 (reproductive structure development), GO:0009793 (embryo development ending in seed dormancy), GO:0048731 (system development), GO:0061458 (reproductive system development), GO:0010154 (fruit development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)