lokahq/bioreason-rl huggingface dataset:
Protein: Nociceptin receptor (A0A0R4IZH2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin
Subcellular location: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle
InterPro domains:
- IPR001420: X opioid receptor (family) [99-359]
- IPR001418: Opioid receptor (family) [70-321]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [45-325]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [60-310]
Sequence:
MEFPNDSIGFTDPRHFHLYNESLFQNNFSTFNESDSFFPKGFKITIAVVYMIVCVVGLVGNCLVMYVIIRYTKMKTATNIYIFNLALADALVLATLPFQGTDVFLGFWPFGNALCKVVVSIDYYNMFTSVFTLTVMSMDRYVAVCHPVKALDMRTPHKAKVVNICVWVLASAIGVPAMVLGDVEQDNGIECILVLPDPRSYWDPVFGTCVFLLSFLIPVAIISVCYSLMVKRLRSVRILSGSKEKDRNLRRITRMVLVVVAAFVVCWTPIQIMALAQSLGFNLASVQTVVFMHFCIALGYVNSSLNPVLYAFLDENFKRCFREFCHPSRFGIDAQQSGRMRHITREVAFNCKTTDGNSNPA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0042277 (peptide binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0042923 (neuropeptide binding), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Unconventional myosin-Ic (A0A8M3APY8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, ruffle membrane. Cell projection, stereocilium membrane. Cytoplasm, cell cortex. Cytoplasmic vesicle
InterPro domains:
- IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [13-626]
- IPR001609: Myosin head, motor domain-like (domain) [6-697]
- IPR036072: Class I myosin, motor domain (domain) [28-683]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [10-750]
- IPR000048: IQ motif, EF-hand binding site (binding_site) [698-766]
- IPR010926: Class I myosin tail homology domain (domain) [850-1024]
Sequence:
MMESALTARDRVGVQDFVLLENHTSEVAFIENLRKRFKENLIYTYIGSVLVSVNPYKDLEIYTKQHMERYRGVNFYEVSPHIYAVADNAYRSMRTERRDQCILISGESGAGKTEASKKVLQYYAVTCPASDHVQTVKDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFKGAPVGGHILNYLLEKSRVVHQSNGERNFHIFYQLIEGGEDDLLRRLGLERNAQQYQYLVKGNCPKVSSINDRNDWKTVRKALSVIGFTDDEVEELLNIIASVLHLGNVQYGGEDSGSAYITTDTQIKYLARLLGVDGTVLKEALTHKKIIAKGEELMSPLNQEQAASARDALSKAIYGRTFSWLVNKINDSLAFKDESFSSKNASVIGLLDIYGFEVFQNNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGITWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGDASDITFLEKLENTVGGHAHFLTHKLADGKTRKVMGREEFRLIHYAGEVNYNVKGFLDKNNDLLFRNLKQVMCMSENKILNQCFDREELSDKKRPETAATQFKNSLAKLMEILMSKEPSYVRCIKPNDAKQAGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRRYETFLQRYKSLCPDTWPNWDGRQVDGVSTLVKHLGYKPEEYKLGRTKIFIRFPKTLFATEDALEVRKHSLATQLQSSWKGYSQKTKYQKMRHSAVWIQAWWRGILARRAAKRRREAADTIRRFIKGFIYRHQPRCPENEYFLDYVRYSFLMNLHRCQPKTVLDKSWPTPPPALVEASQHLRKLCMQNMVRKYCKNINPEWKHQMEQKVVASKIFKDKKDNYPQSVPKLFVNTRLNGEDINPKVLQALGNEKMKYAVPVIKYDRKGYKARNRQLLLMSDSAVIVEEGKLKQRIDYNSLKGISVSSLSDGMFVFHVASEDNKQKGDVVLQNEHVIETLTKVAICADKMDDININQGSIKFDVAQGKEGIIDFTAGSELLIVKAKNGHLSVTAPRLNSR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003774 (cytoskeletal motor activity), GO:0140657 (ATP-dependent activity), GO:0008289 (lipid binding), GO:0000146 (microfilament motor activity), GO:0044877 (protein-containing complex binding), GO:0043167 (ion binding), GO:0005543 (phospholipid binding), GO:0043168 (anion binding), GO:0043325 (phosphatidylinositol-3,4-bisphosphate binding), GO:0035091 (phosphatidylinositol binding), GO:0005547 (phosphatidylinositol-3,4,5-trisphosphate binding), GO:0005546 (phosphatidylinositol-4,5-bisphosphate binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:1902936 (phosphatidylinositol bisphosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0072006 (nephron development), GO:0048731 (system development), GO:0032835 (glomerulus development), GO:0048513 (animal organ development), GO:0072001 (renal system development), GO:0001822 (kidney development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Protein sprouty homolog 4 (A0A8M9PQ80)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR051192: Sprouty domain-containing protein (family) [14-299]
- IPR007875: Sprouty (family) [175-290]
Sequence:
MESRVPHHIPGVSSSIMVQPLLDSRVPYGRLQHPLTIYPIDQMKALHLENDYIDTPAVISQQPPSHKANPRGQEVLLGAPHHPNLSRCEVPDATTHPWISFSGRPSSISSSSSTSSDQRLLDHAAPTPVVDPYTTGNSHGRTLAAEQPKILSSKNIKTLAALPEEKKKHVLLCEKCGKCRCTECTLPRTLPSCWVCNQECLCSAQNLVDSVTCMCLVKGVFYHCTDEDEEGSCADKPCSCSHSNCCARWSFMAAVSLVLPCLVCYLPATGCAKLSQKCYDGVSRPGCRCKSTQSCKVAEIKACQPEKQAS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0061061 (muscle structure development), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0010646 (regulation of cell communication), GO:0060322 (head development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0030902 (hindbrain development), GO:0021593 (rhombomere morphogenesis), GO:0090288 (negative regulation of cellular response to growth factor stimulus), GO:0021546 (rhombomere development), GO:0007420 (brain development), GO:0030097 (hemopoiesis), GO:0007399 (nervous system development), GO:0042692 (muscle cell differentiation), GO:0055001 (muscle cell development), GO:0060537 (muscle tissue development), GO:0040037 (negative regulation of fibroblast growth factor receptor signaling pathway), GO:0007417 (central nervous system development), GO:0007517 (muscle organ development), GO:0040036 (regulation of fibroblast growth factor receptor signaling pathway), GO:0007519 (skeletal muscle tissue development), GO:0051146 (striated muscle cell differentiation), GO:0060538 (skeletal muscle organ development), GO:0014904 (myotube cell development), GO:0014902 (myotube differentiation), GO:0048741 (skeletal muscle fiber development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Extracellular superoxide dismutase [Cu-Zn] (A5PLA4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen
Subcellular location: Golgi apparatus, trans-Golgi network. Secreted, extracellular space
InterPro domains:
- IPR024134: Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone (family) [44-208]
- IPR036423: Superoxide dismutase-like, copper/zinc binding domain superfamily (homologous_superfamily) [40-204]
- IPR018152: Superoxide dismutase, copper/zinc, binding site (binding_site) [94-104]
- IPR001424: Superoxide dismutase, copper/zinc binding domain (domain) [56-193]
Sequence:
MKKLISVILLALHIQRGDFSDNSDFHLIEAPKLEVFEFNNTIYATCEVSPIPNLPAGQPKIFGQVLFRQVFPNGTAEVKINLRGFPETDNQVRAIHIHQYGDLSQGCVTAGPHYNPQDVPHPNHPGDMGNFMPKQGLIRRFLKLPEVKLFGGQSVLGRAVVVHEKEDDLGMGADEESKRSGNAGRRIAGCVIGITKPHLWQKTEHVEEEESKR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0016209 (antioxidant activity), GO:0003824 (catalytic activity), GO:0004784 (superoxide dismutase activity), GO:0016491 (oxidoreductase activity), GO:0016721 (oxidoreductase activity, acting on superoxide radicals as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0071466 (cellular response to xenobiotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Large ribosomal subunit protein uL3 (A0A2R8Q924)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell
Subcellular location: Cytoplasm. Nucleus, nucleolus
InterPro domains:
- IPR009000: Translation protein, beta-barrel domain superfamily (homologous_superfamily) [4-375]
- IPR044892: Ribosomal protein L3, domain 3, archaeal-type superfamily (homologous_superfamily) [1-273]
- IPR019926: Large ribosomal subunit protein uL3, conserved site (conserved_site) [211-234]
- IPR000597: Large ribosomal subunit protein uL3 (family) [1-375]
- IPR045077: Large ribosomal subunit protein uL3, archaea/eukaryota (family) [1-393]
Sequence:
MSHRKFSAPRHGSLGFLPRKRCKRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVDRPGSKVNKKEVVEAVTVVETPPMIVVGVVGYVMTPRGLRSFKTIFAEHISDECKRRFYKNWYKSKKKAFTKYCKRWQDEEGKKQLEKDFSSMKKYCQIIRIIAHTQMRLLPHRQKKSHLMEIQLNGGTISDKVDWAREKLEQSIPIANVFSQDEMIDVIGVTKGHGCKGVTSRWHTKKLPRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGVGYHNKDGKLVKNNASTDYDLSNKSINPLGGFVHYGEVTNDFLMLKGCVVGTKKRVLTLRKSLLVQTSRRAQEKIDLKFIDTTSKFGHGRFQTIEEKKNFMGPLKKDRLAKEEMA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0003735 (structural constituent of ribosome)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0035272 (exocrine system development), GO:0055123 (digestive system development), GO:0031016 (pancreas development), GO:0031017 (exocrine pancreas development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0044391 (ribosomal subunit), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0043228 (non-membrane-bounded organelle), GO:0015934 (large ribosomal subunit), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0022625 (cytosolic large ribosomal subunit), GO:0005840 (ribosome)
Protein: Tyrosyl-DNA phosphodiesterase 1 (F8W5U2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR010347: Tyrosyl-DNA phosphodiesterase I (family) [31-612]
Sequence:
MSQDSQHGKWSISDSEDEDIIPPTPQKDSVKPIVKPDSQSKPEETPTFLKQEPRLSPKRNENSVKTASAPSMGSEARKSAHVNQANPVKYERNASPAVKRKRETEEGGWNLSSSDDETPAPRNEPQKVNISPKRKKKTEDKRPPSPHGTSYYKEEPADFFETNLMPTNDIYRFYLNKVTGIPKKYNTGALHIKEILSPMFGTLKESVQFNYCFDIPWMVEQYPPEFRNKPVVLVHGEKRESKACLIEQAKPYPHISFCQAKLDIAFGTHHTKMMLLWYEEGFRVIILTSNLIRADWYQKTQGMWMSPLYPRLPQGSPGTAGESLTGFKRDLLEYLEAYRAPELANWIERIKQHDLSETRVYLIGSTPGRYQGPAMEKWGHLRLRKLLSEHTQPMQNEERWHVLGQFSSIGSMGLDKTKWLAAEFQRTLTTLGKAGKSLASPETQMLLIYPSVENVRTSLEGYPAGGSLPYSIQTAQKQLWLHSYFHGWHADVTGRSNAMPHIKTYMRISPDFTQLAWFLVTSANLSKAAWGALEKNNTQIMVRSYELGVLYLPSAFNMSTFPVEKNVFPACSSSIGFPVPFDLPPQRYSSKDRPWIWNIPYTQAPDTHGNVWVPS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0140097 (catalytic activity, acting on DNA), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Large ribosomal subunit protein eL22 (F1QG80)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell
Subcellular location: Cytoplasm
InterPro domains:
- IPR038526: Large ribosomal subunit protein eL22 superfamily (homologous_superfamily) [21-141]
- IPR002671: Large ribosomal subunit protein eL22 (family) [13-139]
Sequence:
MRFFSSSFLPKLSAMAPIKKQVTKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVSIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANTKESYELRYFQINQDEEEEDED
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046649 (lymphocyte activation), GO:0030097 (hemopoiesis), GO:0042110 (T cell activation), GO:0002521 (leukocyte differentiation), GO:0030098 (lymphocyte differentiation), GO:1903131 (mononuclear cell differentiation), GO:0030217 (T cell differentiation), GO:0033077 (T cell differentiation in thymus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: G-protein coupled receptor 6 (A0A0G2L0R2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR001151: G protein-coupled receptor 6 (family) [149-323]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [60-300]
- IPR000723: G protein-coupled receptor 3/6/12 orphan (family) [45-312]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [60-315]
Sequence:
MNESESLTNESAMGFPSSSWLEAETFASNGTLALSSASPNFHVNPWDIMLCLSGTVIACENAIVVAIIFYTPTLRNPMFVLIGSLATADLLAGMGLILNFAFQYLVSSETISLITVGFLVASFTASISSLLAITVDRYLSLYNALTYFSEKTLHYVHLMLVGTWGASLCLGLLPVLGWNCLDDASTCSIVRPLKRSNLTLLATSFFIIFILMLSLYFKICKIVCRHAHQIALQQHFFTTSHYVATKKGVSTLAIILGTFGASWLPFAIYCLVGEREYPPVYTYATLLPATYNSMINPIIYAYRNTEIQRSIHMLFCGCFQSNGSYRSRSPSEV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0051716 (cellular response to stimulus), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055074 (calcium ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0006874 (intracellular calcium ion homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: G protein-coupled receptor 185 a (A0A2R9YJM5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [53-293]
- IPR000723: G protein-coupled receptor 3/6/12 orphan (family) [38-305]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [53-301]
Sequence:
MNDLLQNSSLLNWDVLEERNASLAPPWEVEPVPVFINPWDVLLCVTGTLMSCENAVVIALIAYTPTLRAPMFVLIGSLAFADLLAGLGLILNFIITYIIDSGLVTLLSAGLLITAFSASVLNILAITVDRYLSLYNALTYHTERTMTFTYVTLIFMWIISAALGSLPVLGWNCLEDESTCSICRPVNKNNAAALAVSFLLVFALILQLYLQICKIAFRHAQQIAVQRQFMTASHASSTTKGVSTLTTILGTFAFCWIPLAMYSLVADTRSPVIYTYVTALPAICHSIINPMVYAFRNPEILRSLRIACCGCMPYSFSVRPRTPSDV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: G protein-coupled receptor 185 b (F1QSZ7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [63-299]
- IPR000723: G protein-coupled receptor 3/6/12 orphan (family) [48-311]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [63-311]
Sequence:
MIHSLAAAMSNQLQNTSSLSTAGTWNLLDVRNSSPVRTTELRPLPVSPWDIALCVTGTLISCENAIVIAILFYTPTLRAPMFILIGSLAFADLLAGLGLILNFVFIYMLNTEFVTLISVGMLIAAFSASVLNILAITVDRYLSLYNALTYHTERTVTFTYVVVVLIWLVCITLGLLPVLGWNCLRDEASCSICRPVTKNNAVVLAVTFLLVFALMMQLYLQICKIAFRHAQQIAVQHQFMAISTTKGVSTLSVILCTFAVCWMPFAMYSIVADSSYPMIYTYATVLPATCNSVINPIIYAYRNPDIQKSLWLACCGCVPSNFSLRPRTSSDV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0051716 (cellular response to stimulus), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055074 (calcium ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0006874 (intracellular calcium ion homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)