lokahq/bioreason-rl huggingface dataset:
Protein: Zic family member4 (Q08BV0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
InterPro domains:
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [276-379]
- IPR013087: Zinc finger C2H2-type (domain) [233-384]
- IPR043359: C2H2-type zinc-finger protein GLI-like (family) [16-380]
- IPR041643: ZIC protein, zinc finger domain (domain) [213-257]
- IPR056436: ZIC1-5/GLI1-3like, C2H2 zinc finger (domain) [264-293]
Sequence:
MTAEPRLGPSPFGPEHMGHSAALKISPTHHYPHHHHHHNHHIAGHSEVVSSQTGAFGPVQAATVPYSMSHTAQALSAGRDFLIRRDLTAQAMPVLTDQTSGSASHHGMFVSTTGSYPGHYGHHPDPGNHTLFPGLHHDQPSTGAPGGQALNGQIRLGIPAEMYVRSDHLSQVASSRADPFAASPLHGYGGLNLNMNLSAHHHHGAGAFFRYMRQPIKQELICKWLEPEHSAKKLCSKTYSTMHELVTHVTVEHVGGPEQANHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRRFANSSDRKKHSHVHTSDKPYNCKVRGCDKSYTHPSSLRKHMKVHCKSPPPSSGYESSTPSLVSPSSDLGREPAPSALSEPLSSSSQPANLSEWYVCHSSGASGPQTPPSGSSTPGHTEGPTYGNPERRDAF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0008283 (cell population proliferation), GO:0030902 (hindbrain development), GO:0061351 (neural precursor cell proliferation), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0021591 (ventricular system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Dynein regulatory complex protein 8 (EF-hand calcium-binding domain-containing protein 2) (Q5VUJ9)
Organism: Homo sapiens (Human)
Function: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8J3A0}.
InterPro domains:
- IPR011992: EF-hand domain pair (homologous_superfamily) [151-260]
- IPR002048: EF-hand domain (domain) [150-263]
Sequence:
MLGPGQVRLRPRVWRDKAGGRVADGASGLPPARGSWRETGTGRALGASSPPRPAQGSSSPGIQSGPSSRPGSPRGAEQAGTPRPRLSLGISQATGSAARWRTRRTGKGLGYNSDEIRPRTLLIEHLMEGGRRDHHTMTVLWGTQEIIVAEFHKKIKEAFEVFDHESNNTVDVREIGTIIRSLGCCPTEGELHDLIAEVEEEEPTGYIRFEKFLPVMTEILLERKYRPIPEDVLLRAFEVLDSAKRGFLTKDELIKYMTEEDGVSLRRPG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0050794 (regulation of cellular process), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0008277 (regulation of G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) (P21818)
Organism: Rattus norvegicus (Rat)
Function: Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone.
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Cell projection, axon. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus. Endosome. Cell projection, lamellipodium {ECO:0000250}. Note=Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia (By similarity). Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. Exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons. {ECO:0000250}.
InterPro domains:
- IPR030514: Stathmin, conserved site (conserved_site) [74-116]
- IPR000956: Stathmin family (family) [3-179]
- IPR036002: Stathmin superfamily (homologous_superfamily) [39-174]
Sequence:
MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEGRRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0005829 (cytosol), GO:0030427 (site of polarized growth), GO:0036477 (somatodendritic compartment), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0030426 (growth cone), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0030425 (dendrite), GO:0030424 (axon), GO:0005634 (nucleus)
Protein: Small ribosomal subunit protein uS9 (30S ribosomal protein S9) (P0A7X3)
Organism: Escherichia coli (strain K12)
Function: The C-terminal tail plays a role in the affinity of the 30S P site for different tRNAs. Mutations that decrease this affinity are suppressed in the 70S ribosome.
InterPro domains:
- IPR014721: Small ribosomal subunit protein uS5 domain 2-type fold, subgroup (homologous_superfamily) [1-130]
- IPR023035: Small ribosomal subunit protein uS9, bacterial/plastid (family) [1-130]
- IPR000754: Small ribosomal subunit protein uS9 (family) [3-130]
- IPR020568: Ribosomal protein uS5 domain 2-type superfamily (homologous_superfamily) [5-130]
- IPR020574: Small ribosomal subunit protein uS9, conserved site (conserved_site) [69-87]
Sequence:
MAENQYYGTGRRKSSAARVFIKPGNGKIVINQRSLEQYFGRETARMVVRQPLELVDMVEKLDLYITVKGGGISGQAGAIRHGITRALMEYDESLRSELRKAGFVTRDARQVERKKVGLRKARRRPQFSKR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0003735 (structural constituent of ribosome), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0019843 (rRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0065003 (protein-containing complex assembly), GO:0042254 (ribosome biogenesis), GO:0042274 (ribosomal small subunit biogenesis), GO:0022618 (ribonucleoprotein complex assembly), GO:0071826 (ribonucleoprotein complex subunit organization), GO:0000028 (ribosomal small subunit assembly), GO:0042255 (ribosome assembly), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0044391 (ribosomal subunit), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0043228 (non-membrane-bounded organelle), GO:0022627 (cytosolic small ribosomal subunit), GO:0015935 (small ribosomal subunit), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005840 (ribosome)
Protein: Probable G-protein coupled receptor 34 (Q6XCC7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
InterPro domains:
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [50-305]
- IPR048057: Probable G protein-coupled receptor 34, 7TM (domain) [34-316]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [35-313]
Sequence:
MSSTESLQSFSSVWDNRSMWSNRSCPLEEEALRLPLAVLYSLIFLFGLLGNLLALWVFLFLHRRRNSVRVFLINVALADLVLLACLPFRVLYHALGNVWTLGPRMCRVVGNLFYMNMYVSITLLGLISLDRYLKIMGSHRGRRWLRGRSWSLVTCGLLWGLSVLMAVPMMALAEGNEEPGKCYQYKQRKHARGKAYFNLVMVAVFWLVFVVLLVSYGQIARRLLRASQDKPHLPNAARYARTARKSFVVPLLFTVCFVPYHAFRGFYVASQLQDISCETRRLMDRTNEAVLLLSALNSCLDPVMYFLLSGSVRRATLQALAQCLRLHAEPPATNSSTTELRRTSVSHASTTAVLDTSRCSLGNITTLRSQHTDLHPHSEPCVHRSGLSD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Rab11 interacting protein, isoform C (X2JEA7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Recycling endosome {ECO:0000256|ARBA:ARBA00004172}.
InterPro domains:
- IPR019018: Rab-binding domain FIP-RBD (domain) [337-399]
- IPR035892: C2 domain superfamily (homologous_superfamily) [5-156]
- IPR000008: C2 domain (domain) [1-109]
- IPR037245: FIP-RBD, C-terminal domain superfamily (homologous_superfamily) [370-401]
- IPR037789: Rab11-family interacting protein class I (family) [2-314]
Sequence:
MWSPTHCSVTVQRARGLLTKGKNGTNNCFVTIALGKEKYQTSVKDKAETSVNWNEECELKIPDQGNRAELTLTCLHRNNLGIDEFLGQATLPLNEMDVYDRPRAKWFKLESKPGKEKKNKERGELEVRIAFVVKSGSLTDLSKKDKHKSSIGQLASSVGGSLLSIGNGEKRRGIKKLAGSLSSKLHIRSKKKNQEAGADDSSSFGGSFASLGTPNSSNGRGQNGGSGRRRGGQRAGEADPGVISEDEDEFVFDNLSHKSSGSSLNIQRIGLQPPPVGTPNFTPRHPSPLLNNGVSGVGSGSAKDKYNNDNDSNSPSPKSTERIIIGHEKSGSHADRRSEISAQLAKKYEGKSREELMLIANGMENEALLQRQRVKELEDYLDNLLLRVMETHPKILQNPYSRTTSAKSYKNYINMNDFLK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0051020 (GTPase binding), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0009887 (animal organ morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016043 (cellular component organization), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0006996 (organelle organization), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0042461 (photoreceptor cell development), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0042052 (rhabdomere development), GO:0048699 (generation of neurons), GO:0046530 (photoreceptor cell differentiation), GO:0150063 (visual system development), GO:0001745 (compound eye morphogenesis), GO:0048749 (compound eye development), GO:0001754 (eye photoreceptor cell differentiation), GO:0042462 (eye photoreceptor cell development), GO:0042051 (compound eye photoreceptor development), GO:0001751 (compound eye photoreceptor cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle)
Protein: Nimrod C1, isoform B (Nimrod C1, isoform C) (M9PBB4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
InterPro domains:
- IPR053255: Epidermal growth factor-like domain-containing protein (family) [148-408]
- IPR011489: EMI domain (domain) [27-97]
- IPR000742: EGF-like domain (domain) [98-446]
Sequence:
MDFTAFSLHFVCLSLSFGTSFAILRHGLNDCSHPESVPYNRKVLKSKLVPFQQYSYFHGWVTKYRHQYVYEDETAYRTVMRPSCCEGYEGSVENCKPVCRQQCPQHGFCSSPNTCSCNAGYGGIDCHPVCPTVCGKNEFCDRPGVCSCQNGYKRTSPSDNCLPVCEKECGHHSFCSEPGKCECEPGYEKVGNGTVFPDGYKNNSNGNCSPICPKDCGQNSRCVRPGVCECENGYAGDDGGTNCRPVCSTCPENGLCLSPGVCVCKPGYVMRNDLCQPHCEKCSDNAHCVAPNQCECFPGYESSGADKKCVPKCSKGCTNGFCFAPETCVCSIGYQMGPNQVCEPKCSLNCVHGKCTSPETCTCDPGYRFKDNSHHECDPICDSGCSNGHCVAPNFCICHDGYQLNSTNPVTSMCQPICKGCQFGDCVAPNVCECNVGYENINGLCELQTTTDSYEYSTTTVELQSSTVDPQLQTSTSEVPHSNCTAGCMCWIEYDGMGTFNTAKCAKICVDPQDKPCLNLDNCQCDLSSGQLVCQEDSDMDYSGENSRYVCHILPEQGARSEAEVRIPDRTGSSNKWMIIVGSCAGMIIGVAATIIGIKYYRRSTSRRNFEAEEAIVECDFE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0072341 (modified amino acid binding), GO:0008289 (lipid binding), GO:0005543 (phospholipid binding), GO:0001786 (phosphatidylserine binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0051234 (establishment of localization), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0009617 (response to bacterium), GO:0006810 (transport), GO:0098542 (defense response to other organism), GO:0016192 (vesicle-mediated transport), GO:0042742 (defense response to bacterium), GO:0006909 (phagocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: High-affinity nickel transport protein nic1 (O74869)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: High-affinity nickel transporter responsible for nickel uptake. Required for urease biosynthesis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
InterPro domains:
- IPR011541: Nickel/cobalt transporter, high-affinity (family) [69-347]
- IPR004688: Transition metal uptake transporter nickel/cobalt (family) [18-373]
Sequence:
MNSMSEYVKPRKNEFLRKFENFYFEIPFLSKLPPKVSVPIFSLISVNIVVWIVAAIVISLVNRSLFLSVLLSWTLGLRHALDADHITAIDNLTRRLLSTDKPMSTVGTWFSIGHSTVVLITCIVVAATSSKFADRWNNFQTIGGIIGTSVSMGLLLLLAIGNTVLLVRLSYWLWMYRKSGVTKDEGVTGFLARKMQRLFRLVDSPWKIYVLGFVFGLGFDTSTEVSLLGIATLQALKGTSIWAILLFPIVFLVGMCLVDTTDGALMYYAYSYSSGETNPYFSRLYYSIILTFVSVIAAFTIGIIQMLMLIISVHPMESTFWNGLNRLSDNYEIVGGCICGAFVLAGLFGISMHNYFKKKFTPPVQVGNDREDEVLEKNKELENVSKNSISVQISESEKVSYDTVDSKV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0005381 (iron ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0051641 (cellular localization), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0051649 (establishment of localization in cell), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006810 (transport), GO:0098657 (import into cell), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055072 (iron ion homeostasis), GO:0033212 (iron import into cell), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006826 (iron ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: GEL complex subunit OPTI (Obligate partner of TMCO1 insertase) (Rab5-interacting protein) (RIP5) (Respirasome Complex Assembly Factor 1) (RCAF1) (Q9CQT9)
Organism: Mus musculus (Mouse)
Function: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (By similarity). In addition to its role in multi-pass membrane insertion, RAB5IF/OPTI also acts as an assembly factor for mitochondrial respiratory complexes.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A0A8I3S9V6}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:31536960}; Multi-pass membrane protein {ECO:0000255}.
InterPro domains:
- IPR029008: ER membrane protein complex subunit 6-like (family) [44-123]
- IPR010742: Respirasome Complex Assembly Factor 1 (family) [1-128]
Sequence:
MSGGRRKEEPPQPQLANGALKVSVWSKVLRSDAAWDDKDEFLDVIYWFRQIIALVLGVIWGVLPLRGFLGIAGFCLINAGVLYLYFSNYLQIDEEEYGGTWELTKEGFMTSFALFMVIWIIFYTAIHYD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Basic helix-loop-helix (BHLH) DNA-binding superfamily protein (F4KAJ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
InterPro domains:
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [51-106]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [48-117]
- IPR054502: Plant bHLH transcription factor, ACT-like domain (domain) [157-214]
- IPR051358: Transcription factor AMS/ICE1/BHLH6-like (family) [41-214]
Sequence:
MEDIVDQELSNYWEPSSFLQNEDFEYDRSWPLEEAISGSYDSSSPDGAASSPASKNIVSERNRRQKLNQRLFALRSVVPNITKMDKASIIKDAISYIEGLQYEEKKLEAEIRELESTPKSSLSFSKDFDRDLLVPVTSKKMKQLDSGSSTSLIEVLELKVTFMGERTMVVSVTCNKRTDTMVKLCEVFESLNLKILTSNLTSFSGMIFHTVFIELRPNIYWVVWFLVFMSIFGPTIIVIWSIWFIKKKIILSLWRMKKNKRCCG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)