Protein: Phospholipase A and acyltransferase 1 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 1) (HRSL1) (Phospholipid-metabolizing enzyme A-C1) (Q9HDD0)
Organism: Homo sapiens (Human)
Function: Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs).
Subcellular location: [Isoform 1]: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:27623847}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:27623847}. Cytoplasm {ECO:0000269|PubMed:27623847}.
InterPro domains:
- IPR051496: H-rev107 Phospholipase/Acyltransferase (family) [1-165]
- IPR007053: LRAT domain (domain) [15-135]
Sequence:
MAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGNDTYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLRYGEGVSEQANRAISTVEFVTAAVGVFSFLGLFPKGQRAKYY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016746 (acyltransferase activity), GO:0016298 (lipase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0052689 (carboxylic ester hydrolase activity), GO:0004623 (phospholipase A2 activity), GO:0016410 (N-acyltransferase activity), GO:0008970 (phospholipase A1 activity), GO:0004620 (phospholipase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0044255 (cellular lipid metabolic process), GO:0016043 (cellular component organization), GO:0018904 (ether metabolic process), GO:0006629 (lipid metabolic process), GO:0051128 (regulation of cellular component organization), GO:0035556 (intracellular signal transduction), GO:0001558 (regulation of cell growth), GO:0006662 (glycerol ether metabolic process), GO:0007264 (small GTPase mediated signal transduction), GO:0006996 (organelle organization), GO:0046485 (ether lipid metabolic process), GO:0007265 (Ras protein signal transduction), GO:0007031 (peroxisome organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)