Protein: Chloride intracellular channel protein 2 (Glutaredoxin-like oxidoreductase CLIC2) (EC 1.8.-.-) (Glutaredoxin-like peroxidase CLIC2) (EC 1.11.1.-) (XAP121) (O15247)
Organism: Homo sapiens (Human)
Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15916532}. Membrane {ECO:0000305|PubMed:15916532}; Single-pass membrane protein {ECO:0000305|PubMed:15916532}. Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
InterPro domains:
- IPR053823: CLIC, N-terminal domain (domain) [9-99]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [26-96]
- IPR036282: Glutathione S-transferase, C-terminal domain superfamily (homologous_superfamily) [98-244]
- IPR030253: Chloride intracellular channel protein 2, C-terminal domain (domain) [106-244]
- IPR010987: Glutathione S-transferase, C-terminal-like (domain) [76-239]
- IPR040079: Glutathione transferase family (family) [29-222]
- IPR002946: Intracellular chloride channel (family) [12-245]
Sequence:
MSGLRPGTQVDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYANVAKQKS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015108 (chloride transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0015267 (channel activity), GO:0005253 (monoatomic anion channel activity), GO:0005254 (chloride channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0040013 (negative regulation of locomotion), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0040012 (regulation of locomotion), GO:0010035 (response to inorganic substance), GO:2000145 (regulation of cell motility), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0070887 (cellular response to chemical stimulus), GO:1902074 (response to salt), GO:0048513 (animal organ development), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:2000146 (negative regulation of cell motility), GO:0010038 (response to metal ion), GO:0051592 (response to calcium ion), GO:0071241 (cellular response to inorganic substance), GO:0008544 (epidermis development), GO:1902075 (cellular response to salt), GO:0043588 (skin development), GO:0030334 (regulation of cell migration), GO:0060429 (epithelium development), GO:1901701 (cellular response to oxygen-containing compound), GO:0030855 (epithelial cell differentiation), GO:0030336 (negative regulation of cell migration), GO:0071248 (cellular response to metal ion), GO:0030216 (keratinocyte differentiation), GO:0071277 (cellular response to calcium ion), GO:0009913 (epidermal cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0043229 (intracellular organelle), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)