Protein: Trehalose transporter 1 (Facilitated trehalose transporter Tret1-1) (DmTret1-1) (A1Z8N1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Low-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20035867, ECO:0000269|PubMed:34032568}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:20035867}. Vesicle {ECO:0000269|PubMed:34032568}. Note=Levels at the plasma membrane increase upon starvation (PubMed:34032568). Localizes to vesicles positive for Rab7, Rab10, Rab19 and Rab23; efficient localization to the cell surface from cytoplasmic storage vesicles is dependent on Rab10 while protein turnover may be regulated by Rab7 (PubMed:34032568). {ECO:0000269|PubMed:34032568}.
InterPro domains:
- IPR036259: MFS transporter superfamily (homologous_superfamily) [385-840]
- IPR050549: Major Facilitator Superfamily Trehalose Transporter (family) [390-834]
- IPR020846: Major facilitator superfamily domain (domain) [399-826]
- IPR005829: Sugar transporter, conserved site (conserved_site) [457-706]
- IPR044775: Sugar transporter ERD6/Tret1-like (family) [397-832]
- IPR003663: Sugar/inositol transporter (family) [378-833]
- IPR005828: Major facilitator, sugar transporter-like (family) [400-835]
Sequence:
MSGRDNRGAGGGGGGHQPLSNAMGKLKEKLTRVGDELGYHRVESNLSTSNTATSLDTILPEDPFLFPQVSPQRHPQNTVRTQRLLEDEPPLSFRPLLEDDDINEPPTQQQQRTPLRASGSLELTPLPPPPTSLEIREHRDRQQRGAQGDELQRSKQSLKGSRVSFERRDTGNSNTNSNKAAESSDEDSFEEKRTGFQQQKATSVDHKGILKDLKHILANDNRRQFQAKKHVSLDVKGTRFLQDLLKESSSEEEFHKTRREFQGRKHQSLDPRVTFKLDKVLQGSSTDSDEEGEDAEHKRLIHRPKDITKPVIIDLKDLESESDEDFLTSRQHFQQQRSISTDSRKSRRLYEMDEMDNKRGENIRHAVPFVRQITEDGKPKLEVYRPTTNPIYIWTQVLAALSVSLGSLVVGFVSAYTSPALVSMTDRNITSFEVTQDAGSWVGGIMPLAGLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIACAVNVAMVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFVAGSFMNWSMLAFLGAALPVPFLILMFLIPETPRWFVGRGLEERARKALKWLRGKEADVEPELKGLMRSQADADRQASRNTMLELLKLNNLKPLSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDGNLCTIIVGIVNFLATFIGIVLIDRAGRKILLYVSDIAMVLTLFVLGGFFYCKTYGPDVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICFVGLFFVIIYVPETQGKTLEDIERKMMGRVRRMSSVANIKPLSFNM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015144 (carbohydrate transmembrane transporter activity), GO:0015157 (oligosaccharide transmembrane transporter activity), GO:0015154 (disaccharide transmembrane transporter activity), GO:0008515 (sucrose transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0008643 (carbohydrate transport), GO:0015772 (oligosaccharide transport), GO:0015766 (disaccharide transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)