lokahq/bioreason-rl huggingface dataset:
Protein: Steroid sulfatase (microsomal), isozyme S (Steryl-sulfatase isoform X1) (F1QB82)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
InterPro domains:
- IPR017850: Alkaline-phosphatase-like, core domain superfamily (homologous_superfamily) [23-569]
- IPR050738: Sulfatase enzyme (family) [11-552]
- IPR024607: Sulfatase, conserved site (conserved_site) [72-135]
- IPR000917: Sulfatase, N-terminal (domain) [26-409]
Sequence:
MKSFQWIPCTFCLLLYTADAGSGTKPNFVFMMVDDLGIGDLGCYGNTTLRTPNIDRLALEGVKLTQHIAAAPLCTPSRAAFLTGRYPIRSGMAAHGHMGVFLFSASSGGLPQEEITFAKAVKVQGYSTAVIGKWHLGLNCEDSSDHCHHPNSHGFDYFYGTIMTHLRDCQPGHGSVLYNVYSHIPFKPLSIGLVSLVVLHIRGMLTVSRRVFFSFLILVGLVLSLFRLLVYTFPNLNCFVMRGTEIVEQPYISENLTQRMTSEAIEFLERNSETPFLLFFSFIQVHTGVFASPLFRGRSQHGLYGDAVMEVDWSVGQIMQTLERLNLKDNTLVYMTSDQGPHLEEISVHGEMHGGYSGIYKAGKSTNWEGGIRIPGILSWPGVLPAGNIIDEPTSNMDIFPTVLNLAGASIPDDRVIDGHDLLPLLQGQVKRSEHELLFHYCNAELNAVRWRPPNSSAIWKAFFFTPDFYPKNSSACFHTHVCFCIKPFVTFHDPPLLYDLSKDPTESTPLSPDTEPQFHSVLEVIRAAVSRHTQSLKPVPVQVSPLKIVWKPWLQPCCSSLSQLCRCERDHQIEKVQDGLQKE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0008484 (sulfuric ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0048513 (animal organ development), GO:0031214 (biomineral tissue development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: AGAMOUS-like 52 (MADS-box protein AGL52) (Q9SUT6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
InterPro domains:
- IPR002100: Transcription factor, MADS-box (domain) [1-55]
- IPR036879: Transcription factor, MADS-box superfamily (homologous_superfamily) [12-90]
Sequence:
MKQASSSSSCNPTSLTNRLKTIFKKAEELSILCAIDVCVIYYGPDGDLRTWPKDRETVKNMALRYKEDRKRKKCLNLHEFLEKEKVKDKDKYKGKTNYVKNPNWYPNFDHYSPQQLSQLIQSLERTLSTLQKRLRIVESQKKQNTNLVHQSLTPSYLNQTQHLDPSKFSLYMYNHGDATLSQLPLSASQSNQLINYQMQHGFGQNMCLDNITNNNNFQHPGVSNTQDYSPLLSANNYGLNNHLMQQQDQLHGFDQNLCMMSEIINNNNGLQHPNLSNTVPHEFPYGNTSFSQDMFSSYDGSSLLQTSSLPPLHNIPNSYCFSDNSRLLC
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009791 (post-embryonic development), GO:0090698 (post-embryonic plant morphogenesis), GO:0099402 (plant organ development), GO:1905393 (plant organ formation), GO:1905392 (plant organ morphogenesis), GO:0048731 (system development), GO:0090696 (post-embryonic plant organ development), GO:0010311 (lateral root formation), GO:0048364 (root development), GO:0022622 (root system development), GO:0048528 (post-embryonic root development), GO:0010015 (root morphogenesis), GO:0090697 (post-embryonic plant organ morphogenesis), GO:0048527 (lateral root development), GO:0010101 (post-embryonic root morphogenesis), GO:0010102 (lateral root morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0120025 (plasma membrane bounded cell projection), GO:0090406 (pollen tube)
Protein: Progonadoliberin-1 (Progonadoliberin I) (B7TCB2)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
InterPro domains:
- IPR019792: Gonadoliberin (family) [1-87]
- IPR002012: Gonadotropin-releasing hormone (conserved_site) [25-34]
- IPR004079: Gonadoliberin I precursor (family) [25-85]
Sequence:
MEKPRRRMVATVLLCVLAVGLGLAQHWSYGLQPGGKRSTQLLLGPFQEIANEMEKLEEEQQSACPGSHQNSRSGALREAMERLLEEQGRRKNV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005179 (hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0009617 (response to bacterium), GO:0043207 (response to external biotic stimulus), GO:0002237 (response to molecule of bacterial origin), GO:0033993 (response to lipid), GO:0032496 (response to lipopolysaccharide)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection)
Protein: UPF0182 protein Rv0064 (P9WFL5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
InterPro domains:
- IPR005372: Uncharacterised protein family UPF0182 (family) [1-970]
Sequence:
METGSPGKRPVLPKRARLLVTAGMGMLALLLFGPRLVDIYVDWLWFGEVGFRSVWITVLLTRLAIVAAVALVVAGIVLAALLLAYRSRPFFVPDEPQRDPVAPLRSAVMRRPRLFGWGIAVTLGVVCGLIASFDWVKVQLFVHGGTFGIVDPEFGYDIGFFVFDLPFYRSVLNWLFVAVVLAFLASLLTHYLFGGLRLTTGRGMLTQAARVQLAVFAGAVVLLKAVAYWLDRYELLSSGRKEPTFTGAGYTDIHAELPAKLVLVAIAVLCAVSFFTAIFLRDLRIPAMAAALLVLSAILVGGLWPLLMEQFSVRPNAADVERPYIQRNIEATREAYRIGGDWVQYRSYPGIGTKQPRDVPVDVTTIAKVRLLDPHILSRTFTQQQQLKNFFSFAEILDIDRYRIDGELQDYIVGVRELSPKSLTGNQTDWINKHTVYTHGNGFVAAPANRVNAAARGAENISDSNSGYPIYAVSDIASLGSGRQVIPVEQPRVYYGEVIAQADPDYAIVGGAPGSAPREYDTDTSKYTYTGAGGVSIGNWFNRTVFATKVAQHKFLFSREIGSESKVLIHRDPKERVQRVAPWLTTDDNPYPVVVNGRIVWIVDAYTTLDTYPYAQRSSLEGPVTSPTGIVRQGKQVSYVRNSVKATVDAYDGTVTLFQFDRDDPVLRTWMRAFPGTVKSEDQIPDELRAHFRYPEDLFEVQRSLLAKYHVDEPREFFTTNAFWSVPSDPTNNANATQPPFYVLVGDQQSAQPSFRLASAMVGYNREFLSAYISAHSDPANYGKLTVLELPTDTLTQGPQQIQNSMISDTRVASERTLLERSNRIHYGNLLSLPIADGGVLYVEPLYTERISTSPSSSTFPQLSRVLVSVREPRTEGGVRVGYAPTLAESLDQVFGPGTGRVATARGGDAASAPPPGAGGPAPPQAVPPPRTTQPPAAPPRGPDVPPATVAELRETLADLRAVLDRLEKAIDAAETPGG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044085 (cellular component biogenesis), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0016043 (cellular component organization), GO:0044249 (cellular biosynthetic process), GO:0030030 (cell projection organization), GO:0022607 (cellular component assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)
Protein: Cell number regulator 2 (ZmCNR02) (B6TYV8)
Organism: Zea mays (Maize)
Function: May act as a negative regulator of cell number.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
InterPro domains:
- IPR006461: PLAC8 motif-containing protein (family) [43-167]
Sequence:
MYPKAADEGAQPLATGIPFSGGGGYYQAGGAMAAAFAVQAQAPVAAWSTGLCNCFDDCHNCCVTCVCPCITFGQTAEIIDRGSTSCGTSGALYALVMLLTGCQCVYSCFYRAKMRAQYGLQVSPCSDCCVHCCCQCCALCQEYRELKKRGFDMSIGWHANMERQGRAAAAVPPHMHPGMTR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065007 (biological regulation), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0008285 (negative regulation of cell population proliferation), GO:0042127 (regulation of cell population proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: maleylacetoacetate isomerase (EC 5.2.1.2) (X1WBU0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
InterPro domains:
- IPR040079: Glutathione transferase family (family) [9-192]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [6-111]
- IPR034330: Glutathione S-transferases, class Zeta , C-terminal (domain) [94-207]
- IPR036282: Glutathione S-transferase, C-terminal domain superfamily (homologous_superfamily) [88-211]
- IPR034333: Glutathione S-transferases, class Zeta , N-terminal (domain) [7-81]
- IPR004046: Glutathione S-transferase, C-terminal (domain) [127-195]
- IPR010987: Glutathione S-transferase, C-terminal-like (domain) [93-212]
- IPR005955: Glutathione S-transferases, class Zeta (family) [9-210]
- IPR004045: Glutathione S-transferase, N-terminal (domain) [5-88]
Sequence:
MAAQTKPVLYGYYRSSCSWRVRIAFALKGIEYEQKPINLIKDGGQQLTDQFKAINPMQQVPAVSIDGITLSQSLAIIQYIEETRPEPRLLPADPMQRAHVRIICDIIASGIQPLQNLYVLQKIGEDKVQWAQHFINRGFQALEPVLKETAGKYCVGDEISMADICLVPQVYNADRFKVDMTQYPTIRRLNQTLVEIEAFKASHPSRQPDTPDDLRL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0004364 (glutathione transferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0071466 (cellular response to xenobiotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: RNA-binding protein, putative (Q382C7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
InterPro domains:
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [11-466]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [2-466]
- IPR000504: RNA recognition motif domain (domain) [3-467]
Sequence:
MQTCLLSNIPPCTEDELKRGLLAYGTTVSTVVVPHMRQAAVTMRTAQEAQALLQRGCISLFGQTVKVEPAASPAVPYGAGGISAGGMNNHLGGARINVVVEKCTYPVTKEVLSQVFSMVAPPANVVCGPSGPTTNGWVDYNDIATAQRVVVQLNNNSIYPDCCFMTLTLEHMGSTPRGMGEYGSQGHMPYHPQQPQHQNIHQNQQMSQQQLQAMPFGNNGFNAASARGGRGIRGRARGRGAMGGRGGPVYGSGYPMQHAPYAPGQYGAPPVDSVVIVNSVPETVALHSLWVLLEVYGNVNSLKRQFSSKTSVIAHFQNVHDARLAVQHLQGCPFHGATLTLRHFAGYVERGGKTEWNSGPATDPATQAVLFSCGYHHRTRPTASFNPTGRVRPGRYLFVSNLTEAITDDDLKDVFTNECFELDGYYRKSPTVAIVSLKDVETAVNALIAVHSHQLKERFLRVTFSHFPPAPRSGTEEEVEQALAATEAEAAEVREDVEPQDEQNE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000365 (mRNA trans splicing, via spliceosome), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Testicular tissue protein Li 213 (A0A140VJY6)
Organism: Homo sapiens (Human)
Function: Not known
InterPro domains:
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [258-551]
- IPR019412: IML2-like/Tetratricopeptide repeat protein 39-like (family) [18-561]
- IPR019734: Tetratricopeptide repeat (repeat) [280-544]
Sequence:
MGQKGHKDSLYPCGGTPESSLHEALDQCMTALDLFLTNQFSEALSYLKPRTKESMYHSLTYATILEMQAMMTFDPQDILLAGNMMKEAQMLCQRHRRKSSVTDSFSSLVNRPTLGQFTEEEIHAEVCYAECLLQRAALTFLQDENMVSFIKGGIKVRNSYQTYKELDSLVQSSQYCKGENHPHFEGGVKLGVGAFNLTLSMLPTRILRLLEFVGFSGNKDYGLLQLEEGASGHSFRSVLCVMLLLCYHTFLTFVLGTGNVNIEEAEKLLKPYLNRYPKGAIFLFFAGRIEVIKGNIDAAIRRFEECCEAQQHWKQFHHMCYWELMWCFTYKGQWKMSYFYADLLSKENCWSKATYIYMKAAYLSMFGKEDHKPFGDDEVELFRAVPGLKLKIAGKSLPTEKFAIRKSRRYFSSNPISLPVPALEMMYIWNGYAVIGKQPKLTDGILEIITKAEEMLEKGPENEYSVDDECLVKLLKGLCLKYLGRVQEAEENFRSISANEKKIKYDHYLIPNALLELALLLMEQDRNEEAIKLLESAKQNYKNYSMESRTHFRIQAATLQAKSSLENSSRSMVSSVSL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0030182 (neuron differentiation), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0048699 (generation of neurons), GO:0046530 (photoreceptor cell differentiation), GO:0150063 (visual system development), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0001754 (eye photoreceptor cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: GH04611p (Q95SS0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
InterPro domains:
- IPR042447: Anosmin-1 (family) [17-143]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [95-229]
- IPR003961: Fibronectin type III (domain) [31-248]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [52-250]
Sequence:
MNAQRCRSVVPPVADPMCVEPLGVRNNTQLPPIPKILYFRRSRGHAVDLKIESSLLVYYFHVEVRSHIGRHFAARKLGPWQWQKVEKTMEENIGHSKHTYIFFHMRPGRWYEVRVAAVNAYGFRGYSEPSDPFPSTGNPKPPKSPNDSKIIGKQFDGRYMTLKLVWCPSKSNLPVEKYKITWSLYVNSAKASMITNSSYVKDTHQFEIKELLPNSSYYIQVQAISYLGSRRLKSEQWSMLFNTTLQPLEPITPLQCSGNGNRRRHHHTSSSMSSERATTSEPVALNEVSPTITNRTSAAATYEVGFRLNRKFGMIVQILGFQPHKEKVYELCPQETNCEQREFRAIRAKKDPLEFSKLKYNTTYVLRIPRSSPNSVLDDSRNVFTFTTPKCENFRKRFPKLQIKCSD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding), GO:0005178 (integrin binding), GO:0005102 (signaling receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0006935 (chemotaxis), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0007411 (axon guidance), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis), GO:0008045 (motor neuron axon guidance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)
Protein: 4-coumarate--CoA ligase 2 (4CL 2) (Os4CL2) (EC 6.2.1.12) ((E)-ferulate--CoA ligase) (EC 6.2.1.34) (4-coumaroyl-CoA synthase 2) (Q42982)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in the phenylpropanoid metabolism by mediating the activation of a number of hydroxycinnamates for the biosynthesis of monolignols and other phenolic secondary metabolites. Catalyzes the formation of CoA esters of cinnamate, 4-coumarate, caffeate and ferulate. Is more efficient with substrates in the following order: ferulate > 4-coumarate > caffeate > cinnamate. Cannot convert sinapate to its corresponding CoA ester. Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester (By similarity).
InterPro domains:
- IPR042099: ANL, N-terminal domain (homologous_superfamily) [25-467]
- IPR000873: AMP-dependent synthetase/ligase domain (domain) [49-430]
- IPR045851: AMP-binding enzyme, C-terminal domain superfamily (homologous_superfamily) [468-568]
- IPR020845: AMP-binding, conserved site (conserved_site) [216-227]
- IPR025110: AMP-binding enzyme, C-terminal domain (domain) [481-556]
Sequence:
MITVAAPEAQPQVAAAVDEAPPEAVTVFRSKLPDIDIPSHLPLHEYCFARAAELPDAPCLIAAATGRTYTFAETRLLCRRAAAALHRLGVGHGDRVMVLLQNCVEFAVAFFAASFLGAVTTAANPFCTPQEIHKQFKASGVKLILTQSVYVDKLRQHEAFPRIDACTVGDDTLTVITIDDDEATPEGCLPFWDLIADADEGSVPEVAISPDDPVALPFSSGTTGLPKGVVLTHRSVVSGVAQQVDGENPNLHMGAGDVALCVLPLFHIFSLNSVLLCAVRAGAAVALMPRFEMGAMLGAIERWRVTVAAVVPPLVLALAKNPFVERHDLSSIRIVLSGAAPLGKELEDALRARLPQAIFGQGYGMTEAGPVLSMCPAFAKEPTPAKSGSCGTVVRNAELKVVDPDTGFSLGRNLPGEICIRGPQIMKGYLNDPEATAATIDVEGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQVPPAELESLLIAHPSIADAAVVPQKDDVAGEVPVAFVVRAADSDITEESIKEFISKQVVFYKRLHKVHFIHAIPKSASGKILRRELRAKLAAC
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0016877 (ligase activity, forming carbon-sulfur bonds), GO:0016878 (acid-thiol ligase activity), GO:0016405 (CoA-ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0009698 (phenylpropanoid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)