lokahq/bioreason-rl huggingface dataset:
Protein: Muscleblind-like protein 3 (Q9NUK0)
Organism: Homo sapiens (Human)
Function: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction
Subcellular location: Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts
InterPro domains:
- IPR054429: Muscleblind-like, CCCH zinc finger (domain) [49-248]
- IPR000571: Zinc finger, CCCH-type (domain) [14-236]
Sequence:
MTAVNVALIRDTKWLTLEVCREFQRGTCSRADADCKFAHPPRVCHVENGRVVACFDSLKGRCTRENCKYLHPPPHLKTQLEINGRNNLIQQKTAAAMFAQQMQLMLQNAQMSSLGSFPMTPSIPANPPMAFNPYIPHPGMGLVPAELVPNTPVLIPGNPPLAMPGAVGPKLMRSDKLEVCREFQRGNCTRGENDCRYAHPTDASMIEASDNTVTICMDYIKGRCSREKCKYFHPPAHLQARLKAAHHQMNHSAASAMALQPGTLQLIPKRSALEKPNGATPVFNPTVFHCQQALTNLQLPQPAFIPAGPILCMAPASNIVPMMHGATPTTVSAATTPATSVPFAAPTTGNQLKF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003725 (double-stranded RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065007 (biological regulation), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:0045596 (negative regulation of cell differentiation), GO:0045661 (regulation of myoblast differentiation), GO:0045662 (negative regulation of myoblast differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Mitoferrin-1 (Q9NYZ2)
Organism: Homo sapiens (Human)
Function: Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
InterPro domains:
- IPR023395: Mitochondrial carrier protein domain superfamily (homologous_superfamily) [25-337]
- IPR018108: Mitochondrial carrier protein, transmembrane region (repeat) [43-330]
Sequence:
MELRSGSVGSQAVARRMDGDSRDGGGGKDATGSEDYENLPTSASVSTHMTAGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGVNVMIMGAGPAHAMYFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQHRSAISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPHRTYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYFLTKRQLENRAPY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:1990542 (mitochondrial transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0006811 (monoatomic ion transport), GO:0034755 (iron ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006826 (iron ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Mitochondrial sheath formation-associated protein (Q8C5Y2)
Organism: Mus musculus (Mouse)
Function: [Isoform Kastor]: Regulates sperm development. May be involved in mitochondrial sheath formation
Subcellular location: [Isoform Kastor]: Mitochondrion outer membrane; Single-pass membrane protein
InterPro domains:
Sequence:
MIVLGWMLFVGLATYMGTFPEAMPPTLKWKERLPGQENKARRRIQALEEELLL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0051093 (negative regulation of developmental process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0033555 (multicellular organismal response to stress), GO:0040008 (regulation of growth), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0048640 (negative regulation of developmental growth), GO:0048638 (regulation of developmental growth), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009308 (amine metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0033013 (tetrapyrrole metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0006778 (porphyrin-containing compound metabolic process), GO:0033014 (tetrapyrrole biosynthetic process), GO:0006779 (porphyrin-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)
Protein: Mitochondrial pyruvate carrier 1-like protein (P0DKB6)
Organism: Homo sapiens (Human)
Function: Mediates the uptake of pyruvate into mitochondria
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
InterPro domains:
- IPR005336: Mitochondrial pyruvate carrier (family) [16-110]
Sequence:
MARMAVLWRKMRDNFQSKEFREYVSSTHFWGPAFSWGLPLAAFKDMKASPEIISGRMTTALILYSAIFMRFAYRVQPRNLLLMACHCTNVMAQSVQASRYLLYYYGGGGAEAKARDPPATAAAATSPGSQPPKQAS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:1990542 (mitochondrial transmembrane transport), GO:1903825 (organic acid transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:1905039 (carboxylic acid transmembrane transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0015718 (monocarboxylic acid transport), GO:0006848 (pyruvate transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: N-alpha-acetyltransferase 40 (Q9USH6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR039949: N-alpha-acetyltransferase 40 (family) [36-199]
- IPR000182: GNAT domain (domain) [39-202]
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [49-179]
Sequence:
MHFLKQYLFYSPRRMKTQEIKNVTLEDVDFLKNLGVWVEIYHHLEKGLLQQCFNLVKKNMEALYRQSSFGWDDSEKLKEMEMEKLEYICIFEKTSKKLVGFLSFEDTVEAGLTCLYIYEIQLDEHIRGRNVGKWLLKNASILAYRRNLKYIFLTVFSANLNALNFYHHFDFVPHESSPQEKKFRSGKVIHPDYYILYTKSRKDW
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity), GO:0034212 (peptide N-acetyltransferase activity), GO:0004596 (peptide alpha-N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0051604 (protein maturation), GO:0010467 (gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0032153 (cell division site), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Glucosamine-6-phosphate isomerase (Q04802)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
InterPro domains:
- IPR006148: Glucosamine/galactosamine-6-phosphate isomerase (domain) [10-232]
- IPR018321: Glucosamine-6-phosphate isomerase, conserved site (conserved_site) [121-139]
- IPR037171: NagB/RpiA transferase-like (homologous_superfamily) [1-242]
- IPR004547: Glucosamine-6-phosphate isomerase (family) [1-244]
Sequence:
MRQAIFSNPNDAAEYLANYIIAKINSTPRTFVLGLPTGSSPEGIYAKLIEANKQGRVSFKNVVTFNMDEYLGLAPSDLQSYHYFMYDKFFNHIDIPRENIHILNGLAANIDEECANYEKKIKQYGRIDLFLGGLGPEGHLAFNEAGSSRNSKTRKVELVESTIKANCRFFGNDESKVPKYALSVGISTILDNSDEIAIIVLGKNKQFALDKTVNGKPNDPKYPSSYLQDHANVLIVCDNAAAGLKSKL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0019239 (deaminase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006040 (amino sugar metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: Putative tyrosine-protein phosphatase OCA1 (Q59XY9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Putative tyrosine-protein phosphatase required for protection against superoxide stress
Subcellular location: Cytoplasm
InterPro domains:
- IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [39-255]
- IPR004861: Atypical dual-specificity phosphatase Siw14-like (family) [40-262]
- IPR020422: Dual specificity protein phosphatase domain (domain) [45-261]
Sequence:
MASITSNSQILINNDSSTNKAPTTNERQLRRINHPPNLRIVPPLNFCPVENQLYRSGQPSIINQSFLNQLNLKTIIWLSSEEPTDEFLEYCNDSSINIEYLGMINEFNSEPATATTTDKQSQSQSQSQSEEQKSQSQSQSQENQHHQFEQSDNNLLQDPSHLISSTIAKINNNNPWDSLNENTIKHALDLIVDKTNYPILICCGMGRHRTGTVIGCLRRLQHWNLNSVSEEYRRFTGSRGGRILVELLIESFNIDLVNINWELAPDWLK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004725 (protein tyrosine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Probable cyclic di-GMP phosphodiesterase PdeI (P75800)
Organism: Escherichia coli (strain K12)
Function: Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG (By similarity). Overexpression reduces biofilm formation. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR035919: EAL domain superfamily (homologous_superfamily) [529-779]
- IPR033418: Periplasmic sensor domain, extracellular (domain) [35-150]
- IPR001633: EAL domain (domain) [526-781]
- IPR050706: Cyclic di-GMP phosphodiesterase-like (family) [90-778]
Sequence:
MLSLYEKIKIRLIILFLLAALSFIGLFFIINYQLVSERAVKRADSRFELIQKNVGYFFKDIERSALTLKDSLYLLKNTEEIQRAVILKMEMMPFLDSVGLVLDDNKYYLFSRRANDKIVVYHQEQVNGPLVDESGRVIFADFNPSKRPWSVASDDSNNSWNPAYNCFDRPGKKCISFTLHINGKDHDLLAVDKIHVDLNWRYLNEYLDQISANDEVLFLKQGHEIIAKNQLAREKLIIYNSEGNYNIIDSVDTEYIEKTSAVPNNALFEIYFYYPGGNLLNASDKLFYLPFAFIIIVLLVVYLMTTRVFRRQFSEMTELVNTLAFLPDSTDQIEALKIREGDAKEIISIKNSIAEMKDAEIERSNKLLSLISYDQESGFIKNMAIIESNNNQYLAVGIIKLCGLEAVEAVFGVDERNKIVRKLCQRIAEKYAQCCDIVTFNADLYLLLCRENVQTFTRKIAMVNDFDSSFGYRNLRIHKSAICEPLQGENAWSYAEKLKLAISSIRDHMFSEFIFCDDAKLNEIEENIWIARNIRHAMEIGELFLVYQPIVDINTRAILGAEALCRWVSAERGIISPLKFITIAEDIGFINELGYQIIKTAMGEFRHFSQRASLKDDFLLHINVSPWQLNEPHFHERFTTIMKENGLKANSLCVEITETVIERINEHFYLNIEQLRKQGVRISIDDFGTGLSNLKRFYEINPDSIKVDSQFTGDIFGTAGKIVRIIFDLARYNRIPVIAEGVESEDVARELIKLGCVQAQGYLYQKPMPFSAWDKSGKLVKE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity), GO:0071111 (cyclic-guanylate-specific phosphodiesterase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0001101 (response to acid chemical), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0043200 (response to amino acid), GO:0010243 (response to organonitrogen compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Ankyrin repeat protein OPG003 (Q76QY7)
Organism: Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Function: May be involved in virus-host protein interaction through the ankyrin repeats and PRANC regions
InterPro domains:
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [48-395]
- IPR018272: PRANC domain (domain) [483-575]
- IPR002110: Ankyrin repeat (repeat) [66-368]
Sequence:
MDEIVNIVRDSMWFIPNVFMDNGENDGHVSVNNVCHMYFAFFDVDTSSHLFKLVIKHCDLNKQLKCGMSPLHCYVMNTRFKPSVLKILLHNGVNNFDNKDNKGHIPLHHYLIYSLSIDNKVFDILTDPIDDFSKSSDLLLCYLRYKFNGRLNYYVLYKLLTKGSDPNCVDEDGLTSLHYYCKHISAFHESNYYKSKSYTKMRAEKRFIYTIINHGANINAVTKIGNTPLHTYLQQYTKHSPRVVYALLSRGADTRIRNNFDCTPIMEYIKNDCVTGHILIMLLNWHEQKYGKLQKEEGHHLLYLFIKHNQGYGSHAFNILRYLLDRFDIQKDEYYNTMTPLHTAFQNCNNNVASYLVYIGYDINLPTKDDKTVFDLVFENRNILFNAGVIHNIIHHRLKVSLPMIKSLFYKMLEFSPYDDYYVKKIIAYCILRDESFTELHSKFCLNEDYKSVFMKNISFDKIDSIIKKCNWDISRLKDIQISDTNLYTVLRTEDIRYRTYLKAIHLDSHISFPMYDDLIEQCHLSMERKSKLVDKVLNKLKSTIDGQSRLSYLPPEIIRNIITKLSDYHLNSMLYGKNHYKYYT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0019048 (modulation by virus of host process), GO:0048523 (negative regulation of cellular process), GO:0044403 (biological process involved in symbiotic interaction), GO:0050794 (regulation of cellular process), GO:0051701 (biological process involved in interaction with host), GO:0031341 (regulation of cell killing), GO:0051709 (regulation of killing of cells of another organism), GO:0052040 (modulation by symbiont of host programmed cell death), GO:0019054 (modulation by virus of host cellular process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0044003 (modulation by symbiont of host process), GO:0039526 (modulation by virus of host apoptotic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0052041 (suppression by symbiont of host programmed cell death), GO:0052150 (modulation by symbiont of host apoptotic process), GO:0043066 (negative regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0019050 (suppression by virus of host apoptotic process), GO:0033668 (suppression by symbiont of host apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0043657 (host cell), GO:0033643 (host cell part), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)
Protein: Soluble interferon gamma receptor OPG193 (P24770)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
Function: Counteracts the antiviral effects of host IFN-gamma. Acts as a soluble IFN-gamma receptor and thus inhibits the interaction between host IFN-gamma and its receptor
Subcellular location: Secreted
InterPro domains:
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [18-211]
- IPR054752: Interferon-gamma receptor, N-terminal domain (domain) [19-98]
- IPR021126: Interferon gamma receptor, D2 domain, poxvirus/mammal (domain) [107-209]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [23-211]
Sequence:
MRYIIILAVLFINSIHAKITSYKFESVNFDSKIEWTGDGLYNISLKNYGIKTWQTMYTNVPEGTYDISAFPKNDFVSFWVKFEQGDYKVEEYCTGLCVEVKIGPPTVTLTEYDDHINLYIEHPYATRGSKKIPIYKRGDMCDIYLLYTANFTFGDSKEPVPYDIDDYDCTSTGCSIDFVTTEKVCVTAQGATEGFLEKITPWSSKVCLTPKKSVYTCAIRSKEDVPNFKDKMARVIKRKFNKQSQSYLTKFLGSTSNDVTTFLSMLNLTKYS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048583 (regulation of response to stimulus), GO:1900047 (negative regulation of hemostasis), GO:0065008 (regulation of biological quality), GO:0051241 (negative regulation of multicellular organismal process), GO:0035821 (modulation of process of another organism), GO:0051239 (regulation of multicellular organismal process), GO:1900046 (regulation of hemostasis), GO:0048585 (negative regulation of response to stimulus), GO:0050818 (regulation of coagulation), GO:0030195 (negative regulation of blood coagulation), GO:0032101 (regulation of response to external stimulus), GO:0030193 (regulation of blood coagulation), GO:0050878 (regulation of body fluid levels), GO:0050819 (negative regulation of coagulation), GO:1903035 (negative regulation of response to wounding), GO:0080134 (regulation of response to stress), GO:0032102 (negative regulation of response to external stimulus), GO:0061045 (negative regulation of wound healing), GO:1903034 (regulation of response to wounding), GO:0061041 (regulation of wound healing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)