lokahq/bioreason-rl huggingface dataset:
Protein: Kinesin-like protein KIF1C (O43896)
Organism: Homo sapiens (Human)
Function: Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
InterPro domains:
- IPR000253: Forkhead-associated (FHA) domain (domain) [524-590]
- IPR032405: Kinesin-associated (domain) [352-522]
- IPR019821: Kinesin motor domain, conserved site (conserved_site) [242-253]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [5-358]
- IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [4-372]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [498-599]
- IPR001752: Kinesin motor domain (domain) [3-356]
Sequence:
MAGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQSKDAPKSFTFDYSYWSHTSTEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVPQLCEDLFSRVSENQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREHPILGPYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEKVSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTLGKVISALADMQSKKRKSDFIPYRDSVLTWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEVARLRELLMAQGLSASALEGLKTEEGSVRGALPAVSSPPAPVSPSSPTTHNGELEPSFSPNTESQIGPEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYHIKDGVTRVGQVDMDIKLTGQFIREQHCLFRSIPQPDGEVVVTLEPCEGAETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIKLEMEKRLQDLENQYRKEKEEADLLLEQQRLYADSDSGDDSDKRSCEESWRLISSLREQLPPTTVQTIVKRCGLPSSGKRRAPRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMRELCRTYGKPDGPGDAWRAVARDVWDTVGEEEGGGAGSGGGSEEGARGAEVEDLRAHIDKLTGILQEVKLQNSSKDRELQALRDRMLRMERVIPLAQDHEDENEEGGEVPWAPPEGSEAAEEAAPSDRMPSARPPSPPLSSWERVSRLMEEDPAFRRGRLRWLKQEQLRLQGLQGSGGRGGGLRRPPARFVPPHDCKLRFPFKSNPQHRESWPGMGSGEAPTPLQPPEEVTPHPATPARRPPSPRRSHHPRRNSLDGGGRSRGAGSAQPEPQHFQPKKHNSYPQPPQPYPAQRPPGPRYPPYTTPPRMRRQRSAPDLKESGAAV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003774 (cytoskeletal motor activity), GO:0140657 (ATP-dependent activity), GO:0003777 (microtubule motor activity), GO:0005515 (protein binding), GO:0008574 (plus-end-directed microtubule motor activity), GO:0019899 (enzyme binding), GO:0044389 (ubiquitin-like protein ligase binding), GO:0031625 (ubiquitin protein ligase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0016192 (vesicle-mediated transport), GO:0048193 (Golgi vesicle transport), GO:0006890 (retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: 26S proteasome non-ATPase regulatory subunit 11 homolog (19S proteosome subunit 9) (AtS9) (26S proteasome regulatory subunit RPN6) (AtRPN6) (26S proteasome regulatory subunit S9 homolog) (Q9LP45)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, RPN6A is required for proteasome assembly (By similarity).
InterPro domains:
- IPR040780: 6S proteasome subunit Rpn6, C-terminal helix domain (domain) [389-415]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [127-320]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [311-393]
- IPR050871: 26S Proteasome and COP9 Signalosome Components (family) [18-416]
- IPR000717: Proteasome component (PCI) domain (domain) [217-400]
- IPR040773: 26S proteasome regulatory subunit Rpn6, N-terminal (domain) [16-125]
Sequence:
MVSYRATTETISLALEANSSEAITILYQVLEDPSSSPEAIRIKEQAITNLCDRLTEEKRGEDLRKLLTKLRPFFSLIPKAKTAKIVRGIIDAVAKIPGTTDLQITLCKEMVEWTRAEKRTFLRQRVEARLAALLMENKEYVEALALLSTLVKEVRRLDDKLLLVDIDLLESKLHFSLRNLPKAKAALTAARTAANAIYVPPAQQGTIDLQSGILHAEEKDYKTGYSYFFEAFESFNALGDPRAVFSLKYMLLCKIMVSQADDVAGIISSKAGLQYVGPDLDAMKAVADAHSKRSLKLFENALRDYKAQLEDDPIVHRHLSSLYDTLLEQNLCRLIEPFSRVEIAHIAELIGLPLDHVEKKLSQMILDKKFAGTLDQGAGCLIIFEDPKADAIYSATLETIANMGKVVDSLYVRSAKIMS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0009057 (macromolecule catabolic process), GO:0030163 (protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0022624 (proteasome accessory complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005838 (proteasome regulatory particle), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:0000502 (proteasome complex), GO:1905368 (peptidase complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:1905369 (endopeptidase complex), GO:0005634 (nucleus)
Protein: Crystal protein (P21837)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
Subcellular location: Cytoplasmic vesicle, esterosome membrane. Note=Membrane-enclosed crystals (esterosome).
InterPro domains:
- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [33-531]
- IPR019819: Carboxylesterase type B, conserved site (conserved_site) [109-119]
- IPR019826: Carboxylesterase type B, active site (active_site) [202-217]
- IPR002018: Carboxylesterase, type B (domain) [34-526]
Sequence:
MNKIIILLIILLSFDIISAAKKFGRKGIRTLGDNEVLLSDGAIRGTVTDTHRVFYGIPFARPPIDELRYEDPQPPKPWSYVRDGTKQRDQCIQDCKLGKGSCSEVGTSEDCLYLDVFIPRTVNPGSKVPVMVFIPGGAFTQGTGSCPLYDGLKFANSSVIVVNVNYRLGVLGFLCTGLLSGNFGFLDQVMALDWVQENIEVFGGDKNQVTIYGESAGAFSVAAHLSSEKSEGKFHRAILSSTPYTVGLKSQTVARGFAGRFSSKIGCDLEDIDCHRSKSPEEILAIQKELGLAIGDKILDAFTIWSPVVDGINVNEQPLTMIKQGTTHDVPTIIGDNQDEAILFVYMTYKNVVIPSSYRTMVHVLFGIANGNKVLEHYPLPGFLKDSRPILSKLLTDYLFRCPGRYHVSKSAQANESPIYHYQYKQVLSGGHSFEACEGLVCHGTELPMVFNTYESALDLDLEEEEEEFAEQLNNYFVNFIKYSNPSHPNGLPTPKVWNPTTKTTNTSLVMKLGFEVKDLITNDPKCDLFDSLSYNGYTKDQNRMRKSKK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0052689 (carboxylic ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0042330 (taxis), GO:0042221 (response to chemical), GO:0006935 (chemotaxis), GO:0043327 (chemotaxis to cAMP)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0005938 (cell cortex)
Protein: Ribosomal lysine N-methyltransferase 1 (EC 2.1.1.-) (Q08961)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates ribosomal protein S18 (RPS18A and RPS18B) at 'Lys-48' and dimethylates ribosomal protein L23 (RPL23A and RPL23B) at 'Lys-106' and 'Lys-110'.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
InterPro domains:
- IPR046341: SET domain superfamily (homologous_superfamily) [3-292]
- IPR050600: SETD3/SETD6 methyltransferase (family) [5-397]
- IPR017119: SET domain containing methyltransferase Efm1/Rkm1 (family) [1-583]
- IPR001214: SET domain (domain) [22-274]
Sequence:
MSSDALKALLQWGASFGVIVPEELKFLYTDLKGIICVCEKDIDNPSIKIPPEIVISRNLPMKFFGLSESTKNINGWLKLFFAKIKFDRDNDTIVDNVRVNDKFKPYLDALPSRLNSPLVWNPSELKRLSSTNIGNSIHEKFEGIFKEWFELVSSSDMFDLERVADDVQTFHNLDELTYEALYEKILKITELQRPTIWYSFPAFLWSHLIFISRAFPEYVLNRNCPDNSIVLLPIVDLLNHDYRSKVKWYPENGWFCYEKIGTASQSRELSNNYGGKGNEELLSGYGFVLEDNIFDSVALKVKLPLDVVSTILETEPSLKLPLLSDYTTYAFENKDCVQQEKKATRSATDYINGVTYFINIQNEQCLEPLLDLFTYLSKAEEEDLHDLRARLQGIQMLRNALQSKLNSITGPPATDDSYAIDPYRVYCADVYTKGQKQILKEALTRLKKLEKTMLSENKHQLLTMSKILKNDPAFAETELPSLFSNEDGEEVIFESTYDLLILWILLKTKKNSYPTKYEWVGQQYTNFKQTAYISDDAKAFHTAYFEKQDDVDLAEVDHAIQFVVDNSFTRTSSTTEETILVRK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016740 (transferase activity), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0016279 (protein-lysine N-methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity), GO:0016278 (lysine N-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0043414 (macromolecule methylation), GO:1901564 (organonitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0008213 (protein alkylation), GO:0018022 (peptidyl-lysine methylation), GO:0018193 (peptidyl-amino acid modification), GO:0018205 (peptidyl-lysine modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Succinate dehydrogenase assembly factor 1, mitochondrial (SDH assembly factor 1) (SDHAF1) (Q9US02)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit sdh2 of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q3E785}.
InterPro domains:
- IPR045295: SDHAF1, LYR domain (domain) [4-66]
- IPR008011: Complex 1 LYR protein domain (domain) [8-65]
Sequence:
MALSGLQRQVIHFYRRCLHAAKAKEQPYNERWMAFVHQEFRKNQTISKRDFFYIEHLLRVGQRQYEAYSRPEVKDIHFS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0022900 (electron transport chain), GO:0022904 (respiratory electron transport chain), GO:0045333 (cellular respiration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Probable GTP-binding protein EngB (P38424)
Organism: Bacillus subtilis (strain 168)
Function: Necessary for normal cell division and for the maintenance of normal septation.
InterPro domains:
- IPR006073: GTP binding domain (domain) [25-143]
- IPR005225: Small GTP-binding domain (domain) [25-189]
- IPR030393: EngB-type guanine nucleotide-binding (G) domain (domain) [22-195]
- IPR019987: GTP-binding protein, ribosome biogenesis, YsxC (family) [7-193]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-195]
Sequence:
MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLINRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITTREELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVRQTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0009892 (negative regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0048523 (negative regulation of cellular process), GO:0051302 (regulation of cell division), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051781 (positive regulation of cell division), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051053 (negative regulation of DNA metabolic process), GO:0051052 (regulation of DNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0006275 (regulation of DNA replication), GO:0008156 (negative regulation of DNA replication), GO:0090329 (regulation of DNA-templated DNA replication), GO:0030174 (regulation of DNA-templated DNA replication initiation), GO:2000104 (negative regulation of DNA-templated DNA replication)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Straw, isoform G (EC 1.10.3.-, EC 1.16.3.1) (A0A0B4KF30)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
InterPro domains:
- IPR045087: Multicopper oxidase (family) [221-764]
- IPR033138: Multicopper oxidases, conserved site (conserved_site) [736-756]
- IPR002355: Multicopper oxidase, copper-binding site (binding_site) [741-752]
- IPR008972: Cupredoxin (homologous_superfamily) [180-779]
- IPR011706: Multicopper oxidase, C-terminal (domain) [605-759]
- IPR001117: Multicopper oxidase, second cupredoxin domain (domain) [352-501]
- IPR011707: Multicopper oxidase-like, N-terminal (domain) [226-336]
Sequence:
MKAMDLNGFYQTFISFLIWGAFSNFPEVFAVRVANSQQNQPKKENQPDLTPMGSFWQQHVATPSSSTPFDSPFFSATHGLVQTHPSIGGSHSGPAPLNGNSLGSGAPSSILAGTKPALTAGSGYLNSRGSLPTSARYPANKITGTVVEPNPKSPFRHLDFSTSATAELRRNPALSAPDECARACREGEPPRICYYHFTLEYYTVLGAACQVCTPNATNTVWSHCQCVLADGVERGILTANRMIPGPSIQVCENDKVVIDVENHMEGMEVTIHWHGIWQRGSQYYDGVPFVTQCPIQQGNTFRYQWTGNAGTHFWHAHTGLQKLDGLYGSVVVRQPPSRDPNSHLYDFDLTTHIMLISDWLHEDAAERYPGRLAVNTGQDPESMLINGKGQFRDPNTGFMTNTPLEIFTITPGRRYRFRMINAFASVCPAQVTIEGHGMTVIATDGEPVHPVDVNTIISFSGERYDFVISADQPVGAYWIQLRGLGECGIRRAQQLAILRYARGPYQPASSPPTYDVGIPQGVILNPLDAICDRKRADAVCVSNLKNAKKVDKGVLVERPDVKIFLPFRFFVYEPKALFIPNTYNRFLVASDADHLISLIDEVSYISPPSPMLSQYNDIPQEYYCNGDNRPVDCGENCQCTHKIDVPLNAIVEVVLVDEVQQINISHPFHLHGTSFYVLGLGRSPDKQIQRMNLKHALELDQRGLLERQYLKPSLKDTVAVPNNGYAILRFRADNPGFWLFHCHFQYHIVIGMNLVFQIGTPNDLPPVPPNFPRCGNHLPPIKTI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016679 (oxidoreductase activity, acting on diphenols and related substances as donors), GO:0016682 (oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0007275 (multicellular organism development), GO:0048856 (anatomical structure development), GO:0042335 (cuticle development), GO:0040003 (chitin-based cuticle development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032501 (multicellular organismal process), GO:0009986 (cell surface)
Protein: Autophagy-related protein (F4IHC1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
InterPro domains:
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [55-161]
- IPR004241: Autophagy protein Atg8 ubiquitin-like (family) [4-161]
Sequence:
MAISSFKHEHPLVEMNIDVEVTKFHLSLLCSVVESLLFTGRRIAISVPWNPKILSLKKRQAEAARIREKYPDRIPVIVERAEKSDVPDIDRKKYLVPADLTVGQFVYVVRKRIKLSPEKAIFIFVKNILPPTAAIMSAIYEEHKDEDGFLYMSYSGENTFGIFF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009620 (response to fungus), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0050832 (defense response to fungus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005776 (autophagosome), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Pre-mRNA-splicing factor cwf5 (Complexed with cdc5 protein 5) (O59800)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity). Involved in pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:10759889}.
InterPro domains:
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [201-288]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [218-285]
- IPR039171: Pre-mRNA-splicing factor Cwc2/Slt11 (family) [1-149]
- IPR048995: STL11/RBM22-like, N-terminal domain (domain) [20-119]
- IPR000504: RNA recognition motif domain (domain) [212-286]
- IPR034356: Slt11, RNA recognition motif (domain) [210-285]
Sequence:
MSHGPKGDINKQEWEDVEFPSICERCLGDNSYVRMTKEPLGQECKICSKPCTIFRWIKERGQKPGKTQICVGCARYKNCCQSCMLDLQFGLPIALRDAALKLVESGPTNDINREFFAQNQQRLLSNGETAYDSQEASAAARNLVKKVEKRELHSRPPKRKLDDVESKQILKEARASDASLNAERPLFPVKKIINGNVSLSINMEPPKDKKIASLFLIGVEDELADYKIRKHFEQYGPLKSVVCSHRAKCAFVNFKTRSSAEIAAAASPDGNVVIEGFRLKVQWGKPRSLGGPEGEVRNAKLADLVMRGSSHGNKTSQKSTIKNIENEDHENTKSPAVAIPIDPNQPRYRSQIPR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0045292 (mRNA cis splicing, via spliceosome), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)