lokahq/bioreason-rl huggingface dataset:
Protein: LP06328p (Q8MZG9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
InterPro domains:
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [42-298]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [44-244]
Sequence:
MSAPTDYLFCPLAYGSALSAIGIYLLRQYMQGGQFTTKTNETGRVAIVTGCNQGIGKETVLELARRGATVYMACRDMKKCENARREIIKATNNQNIFARQLDLCSMKSIRNFAAGFKREQNKLHILINNAGIMDCPKMLTEDGFEMQIGVNHMGHFLLTLLLLDVLKSSAPSRVVVLSSIAHRFGRIKRDDLNSEKSYDRKMAYCQSKLANVLFTRELAKRLSGTGVTVNALHPGVVNTELFRNTPFLGSWFGKLLIAPIIWIFIKTARNGAQTTLYAALDPSLEKVSGRYFSDCKQKHVGSAAQYDDDAQFLWAESEKWTGINI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004033 (aldo-keto reductase (NADP) activity), GO:0008106 (alcohol dehydrogenase (NADP+) activity), GO:0052650 (NADP-retinol dehydrogenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0051235 (maintenance of location), GO:0044238 (primary metabolic process), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0044255 (cellular lipid metabolic process), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006629 (lipid metabolic process), GO:0019915 (lipid storage), GO:0120254 (olefinic compound metabolic process), GO:0006081 (cellular aldehyde metabolic process), GO:0022607 (cellular component assembly), GO:0008104 (protein localization), GO:0006720 (isoprenoid metabolic process), GO:0140042 (lipid droplet formation), GO:0006996 (organelle organization), GO:0042574 (retinal metabolic process), GO:0070925 (organelle assembly), GO:0033365 (protein localization to organelle), GO:0034389 (lipid droplet organization), GO:0006721 (terpenoid metabolic process), GO:0016101 (diterpenoid metabolic process), GO:0140694 (non-membrane-bounded organelle assembly), GO:0001523 (retinoid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)
Protein: REL proto-oncogene, NF-kB subunit (F1M5R1)
Organism: Rattus norvegicus (Rat)
Function: Not known
InterPro domains:
- IPR002909: IPT domain (domain) [185-280]
- IPR042845: Proto-oncogene c-Rel, RHD, N-terminal subdomain (domain) [8-179]
- IPR000451: NF-kappa-B/Dorsal (family) [6-453]
- IPR037059: Rel homology domain (RHD), DNA-binding domain superfamily (homologous_superfamily) [7-179]
- IPR033926: NFkappaB IPT domain (domain) [186-281]
- IPR032397: Rel homology dimerisation domain (domain) [187-282]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [7-188]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [183-295]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [183-307]
- IPR011539: Rel homology domain, DNA-binding domain (domain) [5-182]
- IPR030492: Rel homology domain, conserved site (conserved_site) [23-29]
Sequence:
MASSGYNPYVEIIEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSIQIMNYYGKGKVRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGPERRPLFFQNLGIRCVKKKEVKEAIILRISAGINPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEHGNFTTALPPIVSNPIYDNRAPNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLNDWEAKGIFSQADVHRQVAIVFRTPPYCRAIVEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDAYGNKSKKQKTTLIFQKLLQDCESNLFSHGTVLPETPRSSGVPGQAEPYYSSSGSISNALPHHPSAMPSMVHQPASWSPVTHPTSHPGSTNTLSSFPAGQLSSNSQGVLPFLDGAGMNDLSASNACLFSTDNLARMETPSMSPTDLYSISDVNMLTNRPVSVMTSSTDGMGDTDHPRLVSVNLENPSCNSRLDPRDPRQLHQMSTASMSAAGTSSSSVFVSQSDTFNRPHFSCIDNGLTNEPGLANDAHHPNFAQSSQYSGIDALQSEQLGDSFEYSFFKI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0035556 (intracellular signal transduction), GO:0007249 (I-kappaB kinase/NF-kappaB signaling), GO:1901214 (regulation of neuron death), GO:1901215 (negative regulation of neuron death)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005667 (transcription regulator complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Zinc finger-like gene 1g (B8A500)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
InterPro domains:
- IPR001878: Zinc finger, CCHC-type (domain) [453-469]
- IPR036875: Zinc finger, CCHC-type superfamily (homologous_superfamily) [439-474]
Sequence:
MAESARNYANGATLRTTSEKHGTEPPCVTIDQMLENLNAYLDKRLGLRKCCDDVSKKYSIKHSQSGLWALPDIKRAYGKTQRLCTTTKKDGLSVILVKQILQHEHMCETDKLERENKAEKAKVRALAEQLQNLKKDKERLENENNKLLTLISKQLESRSSSSFVDSEADLSINTCVHDHVNSKIRLAPVIVKHRRTNIEIDNEEGYEDNGERRTRTVTKVVKKYVPYRTYHPATPEQVDKWSKELPDVYKQPRKVWQFLQRLQKIYILHPLDGVMILNVTLRDSDQKRLTESVERRIGESQENIEDGWEAIKNFLFELKPAEVNWARITSCMQKTGESVAEFEERFRQIWTEHSGLNTSEDLDKDTGIPLKTAFVNGLNPEISKDLKIRYDDWDSTVTTFIQIVEWSAKLERAQDVRLRSLQSESLFYKNRTIEDEQKECVYMGYSKLRTKGRCRNCNEEGHWARECKLSLKHQSKDDDHLFKQFQQLTIQQKQTLLNAVQPQGN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0030902 (hindbrain development), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Large ribosomal subunit protein uL6c (50S ribosomal protein L6, chloroplastic) (Protein EMBRYO DEFECTIVE 2394) (O23049)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This protein binds directly to 23S ribosomal RNA and is located at the aminoacyl-tRNA binding site of the peptidyltransferase center.
Subcellular location: Plastid, chloroplast {ECO:0000250}.
InterPro domains:
- IPR019906: Large ribosomal subunit protein uL6, bacterial-type (family) [43-219]
- IPR002358: Large ribosomal subunit protein uL6, conserved site (conserved_site) [197-205]
- IPR020040: Large ribosomal subunit protein uL6, alpha-beta domain (domain) [53-207]
- IPR036789: Large ribosomal subunit protein uL6-like, alpha-beta domain superfamily (homologous_superfamily) [42-223]
- IPR000702: Large ribosomal subunit protein uL6-like (family) [44-218]
Sequence:
MASSLVSSFQPRSAFLGDRNVFKVSSTPFAQVGYSSKTIECKESRIGKQPIAVPSNVTIALEGQDLKVKGPLGELALTYPREVELTKEESGFLRVKKTVETRRANQMHGLFRTLTDNMVVGVSKGFEKKLILVGVGYRATVDGKELVLNLGFSHPVKMQIPDSLKVKVEENTRITVSGYDKSEIGQFAATVRKWRPPEPYKGKGVKYSDEIVRRKEGKAGKKK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009628 (response to abiotic stimulus), GO:0009266 (response to temperature stimulus), GO:0009409 (response to cold)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009532 (plastid stroma), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031967 (organelle envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009570 (chloroplast stroma), GO:0009526 (plastid envelope), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle), GO:0009941 (chloroplast envelope)
Protein: Envelope glycoprotein N (F5HFQ0)
Organism: Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Function: Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity. Also plays a critical role in virion morphogenesis.
Subcellular location: Virion membrane {ECO:0000255|HAMAP-Rule:MF_04037, ECO:0000269|PubMed:12771417}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04037, ECO:0000269|PubMed:12771417}. Host membrane {ECO:0000255|HAMAP-Rule:MF_04037}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04037, ECO:0000269|PubMed:12771417}. Host Golgi apparatus, host trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04037}. Note=When coexpressed with gM, localizes in the host trans-Golgi network. {ECO:0000255|HAMAP-Rule:MF_04037}.
InterPro domains:
- IPR005211: Herpesvirus envelope glycoprotein N domain (domain) [29-109]
- IPR034707: Envelope glycoprotein N (family) [2-109]
Sequence:
MTASTVALALFVASILGHCWVTANSTGVASSTERSSPSTAGLSARPSPGPTSVTTPGFYDVACSADSFSPSLSSFSSVWALINALLVVVATFFYLVYLCFFKFVDEVVHA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0019048 (modulation by virus of host process), GO:0044403 (biological process involved in symbiotic interaction), GO:0035821 (modulation of process of another organism), GO:0051701 (biological process involved in interaction with host), GO:0019054 (modulation by virus of host cellular process), GO:0044003 (modulation by symbiont of host process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0044423 (virion component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Poly A polymerase head domain-containing protein (Q54BQ2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
InterPro domains:
- IPR032828: tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain (domain) [282-319]
- IPR043519: Nucleotidyltransferase superfamily (homologous_superfamily) [59-229]
- IPR002646: Poly A polymerase, head domain (domain) [72-233]
Sequence:
MYTRPISKIEKSQDGYDRLYFHKQTNNEKEKLSPMQTSTPTSLKKDQPHENIKVSIYYSNERESESVDIRLTECEIQLFKELMHVIRDSGCGTTLRVAGGWVRDKLRGDDSNDIDITLDNMMGEAFAELVNKHLSSKHHQTHRIGVIQSNPEQSKHLETATVKVFDMWIDFVNLRSESYTDTSRIPVISIGTPLQDALRRDLTINSLFFNINENRIEDFTGQGINDLRDGIIRTPLPSLTTFLDDPLRVFRSIRFASRLNFKIDEELFKAGSDPVVKDAIKSKISHERIAKEFDGMLSAEEPYLSIELINKFGLFDCLFSLPTVGLDETYIEQLKNSNKDSEKYCEIADSWIGMGKQYEEIDTKRQLILSALMIPFYGIKFKNANKKNKEMSIIHYMFIEYIKFSNKDYDDVSLILECSEQLMEHIIKFVSAGIFNRKEIGLIIHKSAQLWIVVIIISFIKIQYRPNKLQTLFSRYDKPENEKYTIFHKFVGEIKEHDLIGIWNIKRLLNGKQVQDLLNRKPGTWLAPVIQLILEWQLENPSKTEQDCKDWLLTLDIK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016740 (transferase activity), GO:0140098 (catalytic activity, acting on RNA), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0140101 (catalytic activity, acting on a tRNA), GO:0016779 (nucleotidyltransferase activity), GO:0070567 (cytidylyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0031123 (RNA 3'-end processing), GO:0034660 (ncRNA metabolic process), GO:0042780 (tRNA 3'-end processing), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: UDP-glycosyltransferase 74B1 (N-hydroxythioamide S-beta-glucosyltransferase) (EC 2.4.1.195) (Thiohydroximate S-glucosyltransferase) (O48676)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the biosynthesis of glucosinolate. In in vitro assay, may use phenylacetothiohydroximate (PATH), but not phenylacetic acid (PAA), indole-3-acetic acid (IAA) or salicylic acid (SA) as substrate. Specific for the thiohydroximate functional group and does not glucosylate the carboxylate group or a hydroxyl group.
InterPro domains:
- IPR002213: UDP-glucuronosyl/UDP-glucosyltransferase (family) [11-458]
- IPR035595: UDP-glycosyltransferase family, conserved site (conserved_site) [336-379]
Sequence:
MAETTPKVKGHVVILPYPVQGHLNPMVQFAKRLVSKNVKVTIATTTYTASSITTPSLSVEPISDGFDFIPIGIPGFSVDTYSESFKLNGSETLTLLIEKFKSTDSPIDCLIYDSFLPWGLEVARSMELSAASFFTNNLTVCSVLRKFSNGDFPLPADPNSAPFRIRGLPSLSYDELPSFVGRHWLTHPEHGRVLLNQFPNHENADWLFVNGFEGLEETQDCENGESDAMKATLIGPMIPSAYLDDRMEDDKDYGASLLKPISKECMEWLETKQAQSVAFVSFGSFGILFEKQLAEVAIALQESDLNFLWVIKEAHIAKLPEGFVESTKDRALLVSWCNQLEVLAHESIGCFLTHCGWNSTLEGLSLGVPMVGVPQWSDQMNDAKFVEEVWKVGYRAKEEAGEVIVKSEELVRCLKGVMEGESSVKIRESSKKWKDLAVKAMSEGGSSDRSINEFIESLGK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0046527 (glucosyltransferase activity), GO:0035251 (UDP-glucosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0042440 (pigment metabolic process), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:0051552 (flavone metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0009812 (flavonoid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046148 (pigment biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0009813 (flavonoid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: AcrIIA6 (A0A2U7VJX7)
Organism: Streptococcus phage D1024
Function: Not known
InterPro domains:
- IPR049858: Anti-CRISPR type II subtype A6-like (domain) [1-179]
Sequence:
MKINDDIKELILEYMSRYFKFENDFYKLPGIKFTDANWQKFKNGGTDIEKMGAARVNAMLSCLFEDFELAMIGKAQTNYYIDNSLKLNMPFYAYYDMFKKQLLINWLKNNRDDVICGTGRMYTASGNYIANAYLEVALESSRLGGGEYMLQMRFKNYSRSQEPIPSGRQNRLEWIENNLENIR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0019048 (modulation by virus of host process), GO:0044403 (biological process involved in symbiotic interaction), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0019054 (modulation by virus of host cellular process), GO:0044003 (modulation by symbiont of host process), GO:0052200 (response to host defenses), GO:0019049 (mitigation of host antiviral defense response), GO:0030682 (mitigation of host defenses by symbiont)
Cellular Component (CC): GO:0005575 (cellular component), GO:0044423 (virion component), GO:0019028 (viral capsid)
Protein: Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase) (P19623)
Organism: Homo sapiens (Human)
Function: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.
InterPro domains:
- IPR035246: Spermidine synthase, tetramerisation domain (domain) [19-73]
- IPR030668: Spermidine/spermine synthase, eukaryotes (family) [9-302]
- IPR037163: Spermidine synthase, tetramerisation domain superfamily (homologous_superfamily) [1-74]
- IPR030374: Polyamine biosynthesis domain (domain) [18-253]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [16-302]
- IPR001045: Spermidine/spermine synthases (family) [14-301]
- IPR030373: Polyamine biosynthesis domain, conserved site (conserved_site) [97-110]
Sequence:
MEPGPDGPAASGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESVVQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGPAESLFKESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009308 (amine metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006576 (biogenic amine metabolic process), GO:0009309 (amine biosynthetic process), GO:0042401 (biogenic amine biosynthetic process), GO:0006595 (polyamine metabolic process), GO:0006596 (polyamine biosynthetic process), GO:0008216 (spermidine metabolic process), GO:0008295 (spermidine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: N-acetylneuraminic acid outer membrane channel protein NanC (N-acetylneuraminic acid-inducible outer membrane channel) (NanR-regulated channel) (Porin NanC) (P69856)
Organism: Escherichia coli (strain K12)
Function: Outer membrane channel protein allowing the entry of N-acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria (Probable). NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity.
Subcellular location: Cell outer membrane {ECO:0000269|PubMed:19796645}; Multi-pass membrane protein {ECO:0000269|PubMed:19796645}.
InterPro domains:
- IPR009331: Oligogalacturonate-specific porin (family) [1-238]
- IPR053713: Bacterial Outer Membrane Channel Superfamily (homologous_superfamily) [25-238]
Sequence:
MKKAKILSGVLLLCFSSPLISQAATLDVRGGYRSGSHAYETRLKVSEGWQNGWWASMESNTWNTIHDNKKENAALNDVQVEVNYAIKLDDQWTVRPGMLTHFSSNGTRYGPYVKLSWDATKDLNFGIRYRYDWKAYRQQDLSGDMSRDNVHRWDGYVTYHINSDFTFAWQTTLYSKQNDYRYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQGVYNGRDNLSENSYRIGVSFKL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015267 (channel activity), GO:0022829 (wide pore channel activity), GO:0015288 (porin activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0034219 (carbohydrate transmembrane transport), GO:0006810 (transport), GO:0015749 (monosaccharide transmembrane transport), GO:0071702 (organic substance transport), GO:0008645 (hexose transmembrane transport), GO:0008643 (carbohydrate transport), GO:1904659 (glucose transmembrane transport), GO:0046323 (glucose import)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0009279 (cell outer membrane), GO:0019867 (outer membrane), GO:0030313 (cell envelope)