lokahq/bioreason-rl huggingface dataset:
Protein: Proteasome subunit alpha type (B5XG08)
Organism: Salmo salar (Atlantic salmon)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU000551}. Nucleus {ECO:0000256|RuleBase:RU000551}.
InterPro domains:
- IPR029055: Nucleophile aminohydrolases, N-terminal (homologous_superfamily) [1-246]
- IPR034642: Proteasome subunit alpha6 (family) [8-220]
- IPR001353: Proteasome, subunit alpha/beta (family) [35-220]
- IPR050115: Proteasome subunit alpha (family) [13-238]
- IPR000426: Proteasome alpha-subunit, N-terminal domain (domain) [9-31]
- IPR023332: Proteasome alpha-type subunit (family) [24-239]
Sequence:
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSLAIRGQDCAVVVTQKKVPDKLLDASTVTHLFKITENIGCVMSGMAADSKSQVQRARYEAANWKYKYGYEIPVDMLCKRMADVSQVYTQNAEMRPLGCCMIVIGVDEECGPQVYKCDPAGYYCGFKATAAGVKQTEATTFLEKKVKKKLDWTFAQTIETAITCLSTVLSIDFKPSELEIGVITTEDPKFRILTETEIDVHLVSLSERD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0019899 (enzyme binding), GO:0035375 (zymogen binding), GO:0140297 (DNA-binding transcription factor binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0097677 (STAT family protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0034097 (response to cytokine), GO:0034341 (response to type II interferon), GO:0071310 (cellular response to organic substance), GO:0071346 (cellular response to type II interferon), GO:0071345 (cellular response to cytokine stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)
Protein: Microfibrillar-associated protein 5 (MFAP-5) (MP25) (Microfibril-associated glycoprotein 2) (MAGP-2) (Q28022)
Organism: Bos taurus (Bovine)
Function: May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix.
InterPro domains:
- IPR008673: Microfibril-associated glycoprotein (family) [3-160]
Sequence:
MTFFGPKVLLLLTALIMSSGRTPLGVSGQRGDDVTTVTSETFTEDPNLVNDPATDETVLADIQPSTDDLASLNDKNTTTECRDEKFACTRLYSVHRPIKQCLHQICFTSSRRMYVINNEICSRLVCKEHEAMKDELCRQKAGLPPRRLRRSNYFRLPPCDNVNLQGPSGL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005201 (extracellular matrix structural constituent)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0009893 (positive regulation of metabolic process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051239 (regulation of multicellular organismal process), GO:0009653 (anatomical structure morphogenesis), GO:0051094 (positive regulation of developmental process), GO:0051240 (positive regulation of multicellular organismal process), GO:0045597 (positive regulation of cell differentiation), GO:0045595 (regulation of cell differentiation), GO:0009887 (animal organ morphogenesis), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0030858 (positive regulation of epithelial cell differentiation), GO:0030324 (lung development), GO:0030323 (respiratory tube development), GO:0043588 (skin development), GO:0060429 (epithelium development), GO:0008544 (epidermis development), GO:0030855 (epithelial cell differentiation), GO:0009913 (epidermal cell differentiation), GO:0030216 (keratinocyte differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0099080 (supramolecular complex), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0099081 (supramolecular polymer), GO:0031012 (extracellular matrix), GO:0001527 (microfibril), GO:0099512 (supramolecular fiber), GO:0062023 (collagen-containing extracellular matrix)
Protein: E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb protein X 1) (Ligand of Numb-binding protein 1) (Numb-binding protein 1) (RING-type E3 ubiquitin transferase LNX) (O70263)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.
Subcellular location: Cytoplasm.
InterPro domains:
- IPR036034: PDZ superfamily (homologous_superfamily) [269-725]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [60-69]
- IPR051342: PDZ domain-containing scaffold protein (family) [30-720]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [15-142]
- IPR001478: PDZ domain (domain) [278-724]
- IPR001841: Zinc finger, RING-type (domain) [45-83]
Sequence:
MNQPDLADDPDPSPEPLCIVCGQNHSPEENHFYTYTEDVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDFCPVDRKPVVLQHCKKSSILVNKLLNKLLVTCPFTEHCTEVLQRCDLQHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLMATTLSPEVSAAATISLMTDEPGLDNPAYVSSVEDGEPVANSSDSGRSNRTRARPFERSTMRSRSFKKINRALSALRRTKSGSVVANHVDQGRDNSENTTVPEVFPRLFHLIPDGEITSIKINRADPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLRLTVLREQKFRSRSNAHVPDSYGPRDDSFHVILNKSSPEEQLGIKLVRRVDEPGVFIFNVLNGGVADRHGQLEENDRVLAINGHDLRFGSPESAAHLIQASERRVHLVVSRQVRQSSPDIFQEAGWISNGQQSPGPGERNTASKPAATCHEKVVSVWKDPSESLGMTVGGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVNGIELTEVSRTEAVAILKSAPSSVVLKALEVKEQEAQEDCSPAALDSNHNVTPPGDWSPSWVMWLELPQYLCNCKDVILRRNTAGSLGFCIVGGYEEYSGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARMLKELKGRITLTIASWPGTFL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0019904 (protein domain specific binding), GO:0030165 (PDZ domain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0008283 (cell population proliferation), GO:0007275 (multicellular organism development), GO:0030154 (cell differentiation), GO:0061351 (neural precursor cell proliferation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0030182 (neuron differentiation), GO:0007399 (nervous system development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Uncharacterized membrane protein C1322.03 (O94543)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Golgi apparatus membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
InterPro domains:
- IPR032800: ML-like domain (domain) [25-184]
- IPR040241: Transient receptor potential channel Flc/Pkd2-like (family) [8-819]
- IPR010308: TRP, C-terminal (domain) [321-565]
Sequence:
MKPRPYSVFLFLHIVFYSLLSAVNGSPSLDYFETCSNFVPRAGIPTFSPYAVIKNFDEVNRMYYIQVVGNLSGVITIVGGNGSHIHAASVYSETYALGKLVTSNTTKLCDVVMDPHSFEVPIKCPWAAGSAAFMVKVPFKSTLSDYSKYELTTLTTRVIVVDGTPEKNVITCMKFGLSTTLYYFYPVISYLVVVSLAYVSFSIIYALFLNPWTGSLDPFKSIFNFNMDPDALRLTSLGFFDFVQYLQFAVSTAQVSVMFPKFYINIMAALSWGTALFRFPIFSEPAEYQFADFADLSVASSSYADYLPKSYGMYSFLDSIGIGTACWLPFLIVMVIYLFAALFVALLVIFLKWLMSRIFNETIAETRWDTWSFIAGSLIRLYFLTYFPTVAYMSFQFVAPPTGYEIIPVLWFIFFGIFIPVYLYMNLAFVEPSSKLLEDQTYLHLFGSIYNSFREERVMFWIFPIAVQFMRGITVGVIGSSGSAQLAIFFILEVANVVAYAYVRPHFPQTSMNTLNTFISTMRLITVILMIPLDPRLKVLGISRDLLAYAILFIHIMVCILFLLLSTQRFMEVSARLLGAKSESKGVPLDRPFGWARVFGINELRRRRLKDPYSNGNTMMFDHSTYNSNEMSVPLTPVSVCSNSLKKDGEAAPPKLFVQTNCIPPVTQASSLVPSKNNTASSSSLMLDSPVTPSSPYSTSQGYSFYRPPKPKSSVRKRDMDQLRALQLDFLNNKPNLLRHDVNYAVREADVYHPHVDTSIDSLSQISSQPFEMRPTAIPPPPKNAFQRAWQIVQSTAKSIWHSDPPKESEKGFVVLRSRPRPNLQKPLPQLHIEPSRDEQYSMERKKTDDSLAESAWSIPHP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006665 (sphingolipid metabolic process), GO:0046467 (membrane lipid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006643 (membrane lipid metabolic process), GO:0030148 (sphingolipid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: PMS1 homolog 2, mismatch repair system component (D4A360)
Organism: Rattus norvegicus (Rat)
Function: Not known
InterPro domains:
- IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [11-231]
- IPR014790: MutL, C-terminal, dimerisation (domain) [670-716]
- IPR037198: MutL, C-terminal domain superfamily (homologous_superfamily) [667-714]
- IPR014762: DNA mismatch repair, conserved site (conserved_site) [105-111]
- IPR014721: Small ribosomal subunit protein uS5 domain 2-type fold, subgroup (homologous_superfamily) [232-364]
- IPR042120: MutL, C-terminal domain, dimerisation subdomain (homologous_superfamily) [660-757]
- IPR038973: DNA mismatch repair protein MutL/Mlh/Pms-like (family) [14-785]
- IPR020568: Ribosomal protein uS5 domain 2-type superfamily (homologous_superfamily) [209-364]
- IPR013507: DNA mismatch repair protein, S5 domain 2-like (domain) [227-364]
- IPR002099: DNA mismatch repair protein MutL/Mlh/PMS (family) [15-409]
Sequence:
MEPTEGASTECAKAIKPIDGKSVHQICSGQVVLSLSTAVKELIENSVDAGATSIDLRLKDYGVDLIEVSDNGCGVEEENFEGLALKHHTSKIREFADLTQVETFGFRGEALSSLCALSDVTISTCHVSASIGTRLVLDHNGKIIQKTPCPRPKGTTVSVQNLFYTLPVRHKEFQRNIKKEYAKMVQVLQAYCIISAGIRVSCTNQLGQGKRQPVVCTSGSSGMKENIGSVFGQKQLQSLVPFVQLPPSDSVCEEYCLSACGTPQSPFRISGFISQCTHGAGRSSTDRQFFFINQRPCDPAKVSRLVNEVYHMYNRHQYPFVVLNVSVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLMGMFDSDANKLSVNQQPLLNVEGNLVKLHTAEVGEQENSPSLRITAEEKRVASVSRLREAYSLHRTTETKSWGPETPELKQSFPSQKRGVSSSCPSDIISYRGLCGSQDKLVSPTDSPGDCMDREKGEKDSGLSSTSAGSEEGFSTPEVASSFSSDCNVSSPEDRPSQENTNCGEQFLEVDDHLSGTGHHLKPEDNGYKCRASLPPTRLSPSNAKRFRTEDRPSNVGVPQNTSAAEVDVAVKINKKIVLLDFSLSSLAKQMKQLQHLKQQSKSEHNYRKFRAKICPGENQAAEDELRREIRKSMFAEMEILGQFNLGFIVTKLKEDLFLVDQHAADEKYNFEMLQQHTVLQAQRLITWVHPSFRARSAPLQMKQLVPAAVCRHAYMWACIDTCTTHVHTFHIMIITAPLIESLLHGELLRECIHLIQVITPGSSCCHCCSQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0044877 (protein-containing complex binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0003697 (single-stranded DNA binding), GO:0004519 (endonuclease activity), GO:0030983 (mismatched DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0009410 (response to xenobiotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Major facilitator superfamily (MFS) profile domain-containing protein (H2FLL7)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
InterPro domains:
- IPR011701: Major facilitator superfamily (family) [58-372]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [2-446]
- IPR000849: Sugar phosphate transporter (family) [1-453]
- IPR020846: Major facilitator superfamily domain (domain) [12-444]
Sequence:
MVQTMSSRKVMVFVVTFVSYGLYHASRKALSGVKSSIKADWLSNSSGHAPLFTNEADAKHFLGSLDAIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFNFYHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGNIFGSIFTAMVLPLGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANRIRLLRRSSSSEPHHNFHGEPISLFKAVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFYAHVGPHMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGSQPALAGNTQAMSTVSGLLDGTGSAGSAVGQLLIPIIQDDLGWKAVFYVFMLLNGFAILAILKRCIIDLKSLRKLRSGEESPLLNDEAGDHED
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015605 (organophosphate ester transmembrane transporter activity), GO:1901505 (carbohydrate derivative transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0098661 (inorganic anion transmembrane transport), GO:0015698 (inorganic anion transport), GO:0035435 (phosphate ion transmembrane transport), GO:0006817 (phosphate ion transport), GO:0015748 (organophosphate ester transport), GO:1901264 (carbohydrate derivative transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: p300/CBP-associated factor (Q568Z2)
Organism: Rattus norvegicus (Rat)
Function: Not known
InterPro domains:
- IPR001487: Bromodomain (domain) [1-81]
- IPR037800: Histone acetyltransferase GCN5 (family) [1-80]
- IPR036427: Bromodomain-like superfamily (homologous_superfamily) [1-82]
Sequence:
MEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASVLEKFFFSKIKEAGLMDK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0048545 (response to steroid hormone), GO:0033993 (response to lipid), GO:0014070 (response to organic cyclic compound), GO:0031960 (response to corticosteroid), GO:0051384 (response to glucocorticoid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Spectrin repeat containing nuclear envelope protein 1 (A0A5F9ZH86)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus membrane {ECO:0000256|ARBA:ARBA00004126}.
InterPro domains:
- IPR056887: Nesprin-1/2 domain (domain) [48-120]
- IPR018159: Spectrin/alpha-actinin (repeat) [242-461]
- IPR002017: Spectrin repeat (repeat) [241-348]
Sequence:
XIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTVHKRWLRFLPF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005654 (nucleoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043233 (organelle lumen), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Protein kinase, putative (Q586Q3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
InterPro domains:
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [262-679]
- IPR050108: Cyclin-dependent kinase (family) [267-677]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [497-509]
- IPR000719: Protein kinase domain (domain) [269-671]
Sequence:
MAELLRKKIEALKSRKAAAEEPVVTPQSSSTTAALAPSSSLPSPSTTVTAAAPAQVKSTCSVPLANLPPAFVSPYTAVVKYRDTVKDPLCAQFTTSVAVELFKTFIQQRHRGNVSVQAQKRARSEDFGATERPVRSKEDNDSAKNEEEVQQQREEGYQHQHHNNSSGEGESLSGVGSGGDGINKNIVHFTHPPLCTVVSYFLPYLEARCFTHSDVKDREGKTTWASEAPDAPSLLQGYVTSLHKNVKSSVKAIRVSGKTRPPCRSVNEYVPVGQIAHGVYGVVYRATEANGSSSSGGGRGRKFALKQVKQRWLEESEVGFPPYLLREFDLLLRLRHPNIVCGREVVLLDKKSNSSKASKQQEVKPATGTTGREVSNEVGRHNHRTDNVQKTNEEPTASGNDDGLPSSCNQGGDKKEEEPPQIKTKLSADKMKDVYLVMEYCPYDLKAFIYHRKGVAALLHLSSANKHPDAPRCFLSRVKCVMQQLFTGVAFLHDHRILHRDIKTSNILISSTGEVKLCDFGLGRHYREGQELTANVVTLMYRAPELHFGITDYSYKMDMWSLGCIMAEIFLKEPLFRAEEESRHFAVICDVIGIPTEETFSGLYKMHEVTRLMRSLKRYNRENTLQQIFSRSNHSGAATLPPSGMDLLNRILRWNPIDRLSAREALEHKFFHEDPLPCMPEELLAPLPTTVAAEQMVGVPSQREGGAAVVAGKSSSETNCAIPQALESCEGGDNEETCGFGETVRSNAESPTADVLRARASNIDEEVEVEVRRR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016310 (phosphorylation), GO:0006468 (protein phosphorylation), GO:0046777 (protein autophosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Uncharacterized protein, isoform B (M9PF18)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
InterPro domains:
- IPR019411: MMM1 domain (domain) [605-665]
- IPR031468: Synaptotagmin-like mitochondrial-lipid-binding domain (domain) [603-897]
Sequence:
MNKKDVSPSGSTVPATSVRTGFLRRRNVVEAGSEPSTSQQAEIAIASGKVKKRGILLARKDVEIESGVEVLEDMIPSTAVHIDHSKDVANKRAEEVTDAGADADSRASLTLPVAPGFSTLASSYVEKESGVRDTRSRISFFSNLSMLSVSQWREKHQGATAFALPVLLSVLLILLMILPVPDFLRGVFATLLFFTVMDCCGGHLRALLEDFMLTTHPERVAFAIPNYKFMPICEIPAVEEHKTIKTYAGWMNEINSYDPNTFSFSLTRAVYVRLDGSILKMSGTNARIPKRRMWNEPPIDRHKIPFTDHRSYDLRDCRIELLPLGLANKRFFNRKYPIQLIIKSNRDVPDEQSSVESQSEATVKTDAKEAKAASSSGTTPPGGEEEKLVDFAGTVMQADLQQLRNTVNPDKELNDITVPCGDEVRLLLFSRCDREKEDWYRRFTNASRGLVHEQDLQVPMARFVEDSDLQAAAARQALLLVTGMGKAGVKSEDEISAGKGNDETDQQTPDGQFETITEEDLLDTPKEESFDGMIMSANVARNSPDYVRFMAVYQACNQSTIPVTRSSVGTMRTTDRRPRKSRRAKRQEDELWKGIDQSLFLGPSGSIVWANVLLGRCLYSWLHDAMLHEKLKEVLQKKLNSIKLPSFMEEVIITNIYLGESPLLCHRVSQPMLDERGVWIDADVTYEGLAHITVTTKLNLLRIRSKTKSPMATDNVPTTSMLPEQSQDLRSLSEVNSENVIYDSDAESSGGSSTESESPPPGNAPENAAGTEFFQNSPGNARRIFKIVDRIAASNLFQYATELPYVQRAMENMNANITLRVDLKGLVARGTLNVPPPPSDRVWVSFRGPPRLWISTKPQVGDKSVDWSIVTNVIESKLCEAVNKFLVYPNMVDFSIPFLSNPNFDEDQGNAAN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0051020 (GTPase binding), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0022406 (membrane docking), GO:0071840 (cellular component organization or biogenesis), GO:0051640 (organelle localization), GO:0140056 (organelle localization by membrane tethering), GO:0016043 (cellular component organization), GO:1990456 (mitochondrion-endoplasmic reticulum membrane tethering)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0012505 (endomembrane system)