Protein: DNA (cytosine-5)-methyltransferase DRM1 (EC 2.1.1.37) (Protein DOMAINS REARRANGED METHYLASE 1) (Q9LXE5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in de novo DNA methylation. Controls asymmetric and CpNpG methylation. Required for FWA gene silencing but not for the maintenance of SUP gene silencing. Functionally redundant to CMT3 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation.
Subcellular location: Nucleus {ECO:0000305}.
InterPro domains:
- IPR015940: Ubiquitin-associated domain (domain) [108-231]
- IPR030380: SAM-dependent methyltransferase DRM (domain) [291-622]
- IPR050390: DNA Cytosine-5 Methyltransferase (family) [60-621]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [298-624]
- IPR001525: C-5 cytosine methyltransferase (family) [499-616]
Sequence:
MVMSHIFLISQIQEVEHGDSDDVNWNTDDDELAIDNFQFSPSPVHISATSPNSIQNRISDETVASFVEMGFSTQMIARAIEETAGANMEPMMILETLFNYSASTEASSSKSKVINHFIAMGFPEEHVIKAMQEHGDEDVGEITNALLTYAEVDKLRESEDMNININDDDDDNLYSLSSDDEEDELNNSSNEDRILQALIKMGYLREDAAIAIERCGEDASMEEVVDFICAAQMARQFDEIYAEPDKKELMNNNKKRRTYTETPRKPNTDQLISLPKEMIGFGVPNHPGLMMHRPVPIPDIARGPPFFYYENVAMTPKGVWAKISSHLYDIVPEFVDSKHFCAAARKRGYIHNLPIQNRFQIQPPQHNTIQEAFPLTKRWWPSWDGRTKLNCLLTCIASSRLTEKIREALERYDGETPLDVQKWVMYECKKWNLVWVGKNKLAPLDADEMEKLLGFPRDHTRGGGISTTDRYKSLGNSFQVDTVAYHLSVLKPLFPNGINVLSLFTGIGGGEVALHRLQIKMNVVVSVEISDANRNILRSFWEQTNQKGILREFKDVQKLDDNTIERLMDEYGGFDLVIGGSPCNNLAGGNRHHRVGLGGEHSSLFFDYCRILEAVRRKARHMRR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0140097 (catalytic activity, acting on DNA), GO:0009008 (DNA-methyltransferase activity), GO:0008168 (methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0032259 (methylation), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:0046483 (heterocycle metabolic process), GO:0019538 (protein metabolic process), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0043414 (macromolecule methylation), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0098542 (defense response to other organism), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0009620 (response to fungus), GO:0006479 (protein methylation), GO:0006325 (chromatin organization), GO:0010468 (regulation of gene expression), GO:0006306 (DNA methylation), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0050832 (defense response to fungus), GO:0006259 (DNA metabolic process), GO:0010629 (negative regulation of gene expression), GO:0008213 (protein alkylation), GO:0006304 (DNA modification), GO:0018193 (peptidyl-amino acid modification), GO:0040029 (epigenetic regulation of gene expression), GO:0006338 (chromatin remodeling), GO:0045814 (negative regulation of gene expression, epigenetic), GO:0018022 (peptidyl-lysine methylation), GO:0016571 (histone methylation), GO:0016570 (histone modification), GO:0034968 (histone lysine methylation), GO:0061647 (histone H3-K9 modification), GO:0031507 (heterochromatin formation), GO:0070828 (heterochromatin organization), GO:0006305 (DNA alkylation), GO:0018205 (peptidyl-lysine modification), GO:0051567 (histone H3-K9 methylation), GO:0140718 (facultative heterochromatin formation), GO:0006346 (DNA methylation-dependent heterochromatin formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)