Protein: (DL)-glycerol-3-phosphatase 1, mitochondrial (EC 3.1.3.21) (5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase) (AtGpp1/PyrP3) (EC 3.1.3.104) (5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate phosphatase) (ARPP phosphatase) (Glycerol-1-phosphatase 1) (AtGPP1) (Haloacid dehalogenase-like hydrolase domain-containing protein GPP1) (F4JTE7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a glycerol-3-phosphatase with higher stereospecificity for L-glycerol-3-phosphate than DL-glycerol-3-phosphate. Can also dephosphorylate in vitro 5-amino-6-(5-phospho-D-ribitylamino)uracil, also known as ARPP.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:27490826}.
InterPro domains:
- IPR036412: HAD-like superfamily (homologous_superfamily) [71-289]
- IPR006439: HAD hydrolase, subfamily IA (family) [207-260]
- IPR023214: HAD superfamily (homologous_superfamily) [74-280]
- IPR045228: Phosphatase Gpp1/Gpp2-like (family) [71-262]
- IPR023198: Phosphoglycolate phosphatase-like, domain 2 (homologous_superfamily) [85-154]
Sequence:
MLTTPTRFVALRIPFRSSNKIPISIAPSPKVFPRKPVIRVPASLRFVATMSTPAAAVNATVTVTDAGRGSITHVIFDMDGLLLDTEKFYTEVQEKILARYNKTFDWSLKAKMMGRKAIEAARLFVDESGISDSLSAEDFIVERESMLQDLFPTSDLMPGASRLLRHLHGKGIPICIATGTHTRHFDLKTQRHRELFSLMHHVVRGDDPEVKEGKPAPDGFLAASRRFEDGPVDPRKVLVFEDAPSGVQAAKNAGMNVIMVPDSRLDKSYCNVADQVLASLLDFKPEEWGLPSFQDSHN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0019203 (carbohydrate phosphatase activity), GO:0050308 (sugar-phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0019400 (alditol metabolic process), GO:0019751 (polyol metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0046165 (alcohol biosynthetic process), GO:0016311 (dephosphorylation), GO:0006071 (glycerol metabolic process), GO:0046173 (polyol biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)