Protein: Protein BREVIS RADIX (AtBRX) (Q17TI5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a regulator of cell proliferation and elongation in the root and shoot. Regulates roots architecture and primary root protophloem differentiation. BRX, BAM3, and CLE45 act together to regulate the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem. Probable transcription regulator. Regulated by the auxin response factor ARF5. Polarly localized in vascular cells and subject to endocytic recycling. Required for CPD expression and for correct nuclear auxin response. Mediates cross-talk between the auxin and brassinosteroid pathways. BRX is a target for auxin-induced, proteasome-mediated degradation.
Subcellular location: Nucleus. Cell membrane {ECO:0000269|PubMed:28652362}; Peripheral membrane protein; Cytoplasmic side. Note=The translocation to the nucleus depends on the auxin concentration. Polar localization at the plasma membrane, rootward oriented, in developing root protophloem cells (PubMed:28652362). {ECO:0000269|PubMed:28652362}.
InterPro domains:
- IPR013591: Brevis radix (BRX) domain (domain) [139-344]
- IPR044532: Protein BREVIS RADIX-like (family) [1-344]
- IPR027988: Transcription factor BREVIS RADIX, N-terminal domain (domain) [24-56]
Sequence:
MFSCIACTKADGGEEVEHGARGGTTPNTKEAVKSLTIQIKDMALKFSGAYKQCKPCTGSSSSPLKKGHRSFPDYDNASEGVPYPFMGGSAGSTPAWDFTNSSHHPAGRLESKFTSIYGNDRESISAQSCDVVLDDDGPKEWMAQVEPGVHITFASLPTGGNDLKRIRFSREMFDKWQAQRWWGENYDKIVELYNVQRFNRQALQTPARSDDQSQRDSTYSKMDSARESKDWTPRHNFRPPGSVPHHFYGGSSNYGPGSYHGGPPMDAARTTTSSRDDPPSMSNASEMQAEWIEEDEPGVYITIRQLSDGTRELRRVRFSRERFGEVHAKTWWEQNRERIQTQYL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0009755 (hormone-mediated signaling pathway), GO:0070887 (cellular response to chemical stimulus), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0097305 (response to alcohol), GO:0032870 (cellular response to hormone stimulus), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0009737 (response to abscisic acid), GO:1901701 (cellular response to oxygen-containing compound), GO:0009738 (abscisic acid-activated signaling pathway), GO:0071215 (cellular response to abscisic acid stimulus), GO:0097306 (cellular response to alcohol), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005829 (cytosol), GO:0055044 (symplast), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0009506 (plasmodesma), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005911 (cell-cell junction), GO:0005634 (nucleus)