lokahq/bioreason-rl huggingface dataset:
Protein: RNA-binding protein 4 (Q9VFT3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
InterPro domains:
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [31-230]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [28-220]
- IPR000504: RNA recognition motif domain (domain) [32-226]
Sequence:
MDAGNCASSACLGDCKGDGKTAIKEEGYEHLRKIFIGGLSTQTTVETLRGFFSQFGIVADAVVLRDPVSNHSRGFGFVTYVDPKSVEIVQRARPHTIDNKIVETKHALPRQDFKRGGGVGSVVGSFGCEAGFMNSKRIFLGGLKEYHDENIVREYFSQFGPVASVKLLMDRETGRQRAFGFLEFVDPSSAEKALAPRKHWILQTLVEVKRSTQKADRRFRFPIFSSVRAGYIPPQPATADSYNYNNPNYNPYLAQSVLPPSAFTNGWAHYVIPMAPKPTPGQNMAASLPSQQLAEHSLNGHGPDMWSSYPKTGIYSAQEWTSSKVAEWGPKAGHKHAQTSTNDRAKIDLKELQAATFNNKLDFGARGDADRMSGAGLGLGLTGGAAVGVGAIKKWPTQDYKVFKPAKSPTNGVIPKIGKEATTPPYGI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003727 (single-stranded RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0034248 (regulation of amide metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0034249 (negative regulation of amide metabolic process), GO:0017148 (negative regulation of translation), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0006417 (regulation of translation), GO:2000113 (negative regulation of cellular macromolecule biosynthetic process), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: RRM domain-containing protein (H2KYB8)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
InterPro domains:
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [167-323]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [155-342]
- IPR016194: SPOC-like, C-terminal domain superfamily (homologous_superfamily) [363-513]
- IPR012921: Spen paralogue and orthologue SPOC, C-terminal (domain) [369-502]
- IPR010912: Spen paralogue/orthologue C-terminal, metazoa (domain) [365-516]
- IPR000504: RNA recognition motif domain (domain) [35-325]
Sequence:
MAEERGRPQYRPNCNGLSSYYRERFGSHSPEVYLNLRISGFDDRLEREQIKQYLTQELKKYAPFEIKVVKNPEEDERLAYVNFERNDCARKVRYTLMDRLKSVLGKRVQCDPAGILRDQEGKYIPDRFNRAQHGADSKREGGSGSGNRGRPTKEPSTWRLKQDDDEATRTLFVGNMPSDVKEREIRHVFEEHGKVEEVDIKTPINTDAAYAFVMFQTVDQAIQAKAEEQDRPIRAGGSRMKIGYGKSQVSRRLFVGGLGSWCDKEILQKAFGEFGFVENIDYDHGQPYAYVVYENTHTSQEACRSLRGACISKGNHPIMVDYAKDLTAQPEKQQFMRKRRASKSPVGASAVRTPPGSPKDVVRNFAELEEAYAATWSGKMALKKTDYPVKFYRVYGAERLPVKLLRDEDDVPLRLLITQRLSLSSQNLLFDKLASCSSKELSLGVITGKKELSDLQPLVNYFTNKEAAGVVTVPGGILYIFPFCEFALKLLAEFTPQVNVFNENCPFLLGALAVRAPGTP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0003006 (developmental process involved in reproduction), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0007548 (sex differentiation), GO:0046661 (male sex differentiation), GO:0080090 (regulation of primary metabolic process), GO:0007530 (sex determination), GO:0030238 (male sex determination), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010468 (regulation of gene expression), GO:0043484 (regulation of RNA splicing), GO:1903311 (regulation of mRNA metabolic process), GO:0050684 (regulation of mRNA processing), GO:0048024 (regulation of mRNA splicing, via spliceosome), GO:0000381 (regulation of alternative mRNA splicing, via spliceosome)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: N-alpha-acetyltransferase 30 (EC 2.3.1.256) (L-A virus GAG protein N-acetyltransferase subunit MAK3) (Maintenance of killer protein 3) (N-terminal acetyltransferase C complex catalytic subunit MAK3) (NatC complex subunit MAK3) (NatC catalytic subunit) (Q03503)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalytic component of the NatC N-terminal acetyltransferase, which catalyzes acetylation of the N-terminus Met of L-A virus GAG protein and possibly GRH1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
InterPro domains:
- IPR044542: N-alpha-acetyltransferase 30-like (family) [3-161]
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [13-159]
- IPR000182: GNAT domain (domain) [3-159]
Sequence:
MEIVYKPLDIRNEEQFASIKKLIDADLSEPYSIYVYRYFLNQWPELTYIAVDNKSGTPNIPIGCIVCKMDPHRNVRLRGYIGMLAVESTYRGHGIAKKLVEIAIDKMQREHCDEIMLETEVENSAALNLYEGMGFIRMKRMFRYYLNEGDAFKLILPLTEKSCTRSTFLMHGRLAT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity), GO:0034212 (peptide N-acetyltransferase activity), GO:0004596 (peptide alpha-N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0051604 (protein maturation), GO:0043412 (macromolecule modification), GO:0010467 (gene expression), GO:0031365 (N-terminal protein amino acid modification), GO:0006474 (N-terminal protein amino acid acetylation), GO:0043543 (protein acylation), GO:0006473 (protein acetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:0031248 (protein acetyltransferase complex), GO:1990234 (transferase complex), GO:0031414 (N-terminal protein acetyltransferase complex), GO:1902493 (acetyltransferase complex)
Protein: Homoserine kinase (HK) (HSK) (EC 2.7.1.39) (P29364)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Not known
InterPro domains:
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [5-306]
- IPR002575: Aminoglycoside phosphotransferase (domain) [27-255]
- IPR050249: Pseudomonas-type Homoserine Kinase (family) [23-285]
- IPR005280: Homoserine kinase, type II (family) [1-316]
Sequence:
MSVFTPLERSTLEAFLAPYDLGRLRDFRGIAEGSENSNFFVSLEHGEFVLTLVERGPVQDLPFFIELLDVLHEDGLPVPYALRTRDGEALRRLEGKPALLQPRLAGRHERQPNAHHCQEVGDLLGHLHAATRGRILERPSDRGLPWMLEQGANLAPRLPEQARALLAPALAEIAALDAERPALPRANLHADLFRDNVLFDGPHLAGLIDFYNACSGWMLYDLAITLNDWCSNTDGSLDPARARALLAAYANRRPFTALEAEHWPSMLRVACVRFWLSRLIAAEAFAGQDVLIHDPAEFEIRLAQRQNVEIHLPFAL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0016054 (organic acid catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0009063 (amino acid catabolic process), GO:0019752 (carboxylic acid metabolic process), GO:1901606 (alpha-amino acid catabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0009066 (aspartate family amino acid metabolic process), GO:0006553 (lysine metabolic process), GO:0006554 (lysine catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Branched-chain amino acid ABC transporter, ATP-binding protein (Q5LSR0)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Function: Not known
InterPro domains:
- IPR003593: AAA+ ATPase domain (domain) [26-218]
- IPR052156: Branched-Chain Amino Acid Transport ATP-binding Protein LivF (family) [1-224]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-228]
- IPR017780: ABC transporter, urea, ATP-binding protein, UrtE (family) [2-231]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [2-231]
Sequence:
MLKLQDLTLHYGHSQILHGISMEAALGEITCVMGTNGVGKTSLIKAISGTHPRSGGEMILDGEPLGVLPAHQLAHKGVAYVPQGREIFPLLTVRENLETGFGCLPASDRLIPDEIFELFPVLKQMQNRRGGDLSGGQQQQLAIARALITRPRLLLLDEPTEGIQPNIIQQIGQVIRHLRSQGTMAIILVEQYFEFAYDLADRFVVLRRGEVLVAGRKGELSKADVLKGVSV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0140359 (ABC-type transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015849 (organic acid transport), GO:0006865 (amino acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0015803 (branched-chain amino acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0098797 (plasma membrane protein complex), GO:0005886 (plasma membrane)
Protein: Nuclear transcription factor Y subunit nfya-2 (CAAT box DNA-binding protein subunit nfya-2) (Q5ZEP9)
Organism: Caenorhabditis elegans
Function: Component of the sequence-specific heterotrimeric transcription factor (nfya-2-NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes to regulate their expression and control cellular identity in particular tissue types. In association with the components in the nfya-2-NF-Y complex, may repress the expression of the T-box transcription factor tbx-2 throughout larval development, which most likely restricts its expression to certain tissues.
Subcellular location: Nucleus {ECO:0000269|PubMed:17574230}.
InterPro domains:
- IPR001289: Nuclear transcription factor Y subunit A (family) [39-219]
Sequence:
MNPRGNPSKMPTQIVLNRRPAAPARPQTTFTSLSQYHMYNTASTSSAPPPPPNQNFGQIREAIRTTQPTTVQLPPDCKLVEYTWQENGESRTVLIPMSNDSTEDDVRSALPQSVLESINQHQNQLRQGNAQAVHYYQKHQNPISHEKPIMVNPRQYKRIIKRREMRQKMEDSGRLPLERQKYMHESRRQHALKRRRTGGRFDANAEAAAASSEPSISSAAPSPPKAPRAPTTYAMIRPATSHPPVNIPKAPAMTYRPVQEEKKSIERISKAQMFTIPKRQQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0045927 (positive regulation of growth), GO:0040008 (regulation of growth), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009790 (embryo development), GO:0048598 (embryonic morphogenesis), GO:0051128 (regulation of cellular component organization), GO:0001558 (regulation of cell growth), GO:0030307 (positive regulation of cell growth), GO:0051128 (regulation of cellular component organization), GO:0009792 (embryo development ending in birth or egg hatching)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Zinc finger protein C19B12.07c (Q9P374)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
InterPro domains:
- IPR041661: ZN622/Rei1/Reh1, zinc finger C2H2-type (domain) [96-186]
- IPR013087: Zinc finger C2H2-type (domain) [148-170]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [136-317]
- IPR040048: Zinc finger protein 277 (family) [7-316]
Sequence:
MSSDDAIIIRCPFDCEFAGDSISFISHLTTIHNSSVQTLAKNAYLCASEIANELNQNPNLKDQEILLLQIAQENSLKRVLRQQQKERREGKIKSLQCLFCNNEGLLNRQEWFEHSFHVHGLNIGLADNIVYINRLLEKIKNELESFRCLCCHVPCKNKKLLREHMNNKRHFRLDPKSSEYDEFYIINYASVTKSITISHSQFAINEDINETDDTISDINDEDAEPLSVECIFCTNFYEPVFCFEHCKIVHDWDIKKIQKDYSLDVYGAIRVINYSRKTKKKSIPAETDSFWKEPGWLIPVVPDDALIICLSEVIEDPRL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Transmembrane protein 176B (Protein LR8) (Q9R1Q6)
Organism: Mus musculus (Mouse)
Function: May play a role in the process of maturation of dendritic cells (By similarity). Required for the development of cerebellar granule cells.
Subcellular location: Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
InterPro domains:
- IPR007237: CD20-like family (family) [61-223]
- IPR009281: Transmembrane protein 176A/B (family) [1-262]
Sequence:
MVQSTVTVNGVKVASTHPQSAHISIHIHQKSALEQLLGAVGSLKKFLSWPQARIHYGQLSLGVTQILLGLVSCALGVCLYFGPWTELCAFGCAFWSGSVAILAGVGTIVHEKRQGKLSGQVSCLLLLACIATAAAATVLGVNSLIRQTSVPYYVEIFSTCNPLQSSMDPGYGTVRYSDDSDWKTERCREYLNMMMNLFLAFCIMLTVVCILEIVVSVASLGLSLRSMYGRSSQALNEEESERKLLDGHPAPASPAKEKIPAIL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0030097 (hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: PRA1 family protein H (AtPRA1.H) (Q8LFP1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in both secretory and endocytic intracellular trafficking in the endosomal/prevacuolar compartments.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18583532}; Multi-pass membrane protein {ECO:0000269|PubMed:18583532}.
InterPro domains:
- IPR004895: Prenylated rab acceptor PRA1 (family) [92-230]
Sequence:
MAFSPNPLSLSVPDPAFESWLRDSGYLELLDHRTSAAAAAASSSASVSSSAAATSAASDDVVSSITGGFFASLLSRLVTVSSLLTINPFSKLSADDFSGDTTPWTTGFIGNCDSYSFPSSSQQARMRVHENIKRFARNYATLFIVFFACALYQMPLALVGLLGSLALWELFKYCSDKWKFDRHPSMRKLSIGIGQCATAVLLTFLNVQMALFSALAISYSVMILHAGFRKLTPSKKPTRGR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0016192 (vesicle-mediated transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Ribosome modulation factor (RMF) (Hibernation factor RMF) (Protein E) (P0AFW2)
Organism: Escherichia coli (strain K12)
Function: During stationary phase, converts 70S ribosomes to an immature dimeric form (90S ribosomes) which are converted to inactive 100S ribosomes (a process called ribosomal hibernation) by the hibernation promoting factor HPF. Inactivates ribosomes by covering the peptidyl transferase (PTase) center of the 23S rRNA and the entrance of peptide exit tunnel. However crystallization with T.thermophilus 70S ribosomes shows it binds near the 3'-end of the 16S rRNA near the anti-Shine-Dalgarno sequence, where it would sterically hinder translation inititation. In this crystal binding of RMF induces movement of the 30S head domain away from the rest of the ribosome, presumably so they would more easily form dimers. Also involved in protection against heat stress, but this role is not dependent on the maintenance of ribosome dimers.
Subcellular location: Cytoplasm {ECO:0000305}.
InterPro domains:
- IPR007040: Ribosome modulation factor (family) [1-55]
- IPR023200: Ribosome modulation factor domain superfamily (homologous_superfamily) [1-55]
Sequence:
MKRQKRDRLERAHQRGYQAGIAGRSKEMCPYQTLNQRSQWLGGWREAMADRVVMA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0009892 (negative regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0065003 (protein-containing complex assembly), GO:0042254 (ribosome biogenesis), GO:0022618 (ribonucleoprotein complex assembly), GO:0042273 (ribosomal large subunit biogenesis), GO:0071826 (ribonucleoprotein complex subunit organization), GO:0042255 (ribosome assembly), GO:0140694 (non-membrane-bounded organelle assembly), GO:0000027 (ribosomal large subunit assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)