Protein: Leucine zipper putative tumor suppressor 2 homolog (A0A8M3AZ07)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
InterPro domains:
- IPR045329: Leucine zipper putative tumor suppressor (family) [1-709]
- IPR028597: Leucine zipper putative tumour suppressor 2 (family) [1-709]
Sequence:
MALVQALPVPTDHPKPSTDVQQCCSVSHSPTVDVTGTMGSVSSLISGRTYQERHCRAASDFGARYRKPTPATSCFRQQEGTLRSSSSQEQLLNSQPPLPAKNKSSALISAGNGNYGYLSDEPVGDWNDNHVSTCSPSSDTEEPSDNRGMNGNIGGPPPKLVPVSGRLEKSMEKILIRPTAFKPVLPKNRNSVQYLSPRSGGSLSESQGSLNLLLPGTGAGSGCQEKRNSYSGGRNARSSQSCTMSDSGRNSLSSLPTYSSTGYSLTQSEVPNGHMETTRSGVGHGHSNSDSGRSSSSKSTGSLSGRGQPLSDSGSCGRSPAPGEGYEGVIRELEEKLRERDLELQQLRDNLDENEAAICQVYEEKQKRCEQEMEDLRQSCASKMKQVQLKAQRAQQVLQLQVFQLQQEKKKLQEDFSQLLQEREALEKRCASFEREQTQFGPRLEETKWEVCQKSGEISLLKQQLKDVQADLGQKASEIVALKAQLREARSELQASQARSQEAHATARTRTLELEVCENELQRRKSEAELLREKMGRLEEESLRLKEAMAVPTPQTLPSKGQSMSLPLPQSRGGIGHGISPAFRDNSSEEQLLAYESDEAKAQRQSVDVLHGLRQQVDRLRAELMYERRRSEDQLEGFEDERRVWQEEKDKVIRYQKQLQQNYIQMYRRNRDLERVMRELSLELENRDMEEFDMRSNEIHFEEITATEI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008013 (beta-catenin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0048584 (positive regulation of response to stimulus), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0009967 (positive regulation of signal transduction), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0009790 (embryo development), GO:0010647 (positive regulation of cell communication), GO:0016477 (cell migration), GO:0090100 (positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0007369 (gastrulation), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0009953 (dorsal/ventral pattern formation), GO:0030111 (regulation of Wnt signaling pathway), GO:0002009 (morphogenesis of an epithelium), GO:0030510 (regulation of BMP signaling pathway), GO:0030178 (negative regulation of Wnt signaling pathway), GO:0060429 (epithelium development), GO:0001667 (ameboidal-type cell migration), GO:0060026 (convergent extension), GO:0042074 (cell migration involved in gastrulation), GO:0030513 (positive regulation of BMP signaling pathway), GO:0090090 (negative regulation of canonical Wnt signaling pathway), GO:0060828 (regulation of canonical Wnt signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0097546 (ciliary base), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium)