Protein: Neuronal vesicle trafficking-associated protein 1 (M234) (Neuron-enriched endosomal protein of 21 kDa) (Neuron-specific protein family member 1) (p21) (Q62092)
Organism: Mus musculus (Mouse)
Function: Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:P02683}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P02683}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P02683}. Endosome membrane {ECO:0000250|UniProtKB:P02683}. Cell projection, dendrite {ECO:0000250|UniProtKB:P02683}. Early endosome membrane {ECO:0000250|UniProtKB:P02683}. Late endosome membrane {ECO:0000269|PubMed:28874679}. Lysosome lumen {ECO:0000250|UniProtKB:P02683}. Recycling endosome membrane {ECO:0000250|UniProtKB:P02683}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P02683}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P02683}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:P02683}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P42857}. Note=Endocytosed from the cell surface, thus enters into early endosomes, trafficks to late endosomes and degradates in lysosomes (By similarity). Endoplasmic reticulum targeting is essential for apoptosis (By similarity). Found in both stationary and motile endosomes (PubMed:28874679). A previous study supports a type I membrane protein topology (PubMed:12070131). {ECO:0000250|UniProtKB:P02683, ECO:0000250|UniProtKB:P42857, ECO:0000269|PubMed:12070131, ECO:0000269|PubMed:28874679}.
InterPro domains:
- IPR009431: Neuronal vesicle trafficking-associated protein (family) [1-185]
Sequence:
MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKKGKARPPKIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVVYKVYKYDRACPDGFVLKNTQCIPEGLESYYTEQDSSAREKFYTVINHYNVAKQSITRSVSPWMSVLSEEKLSEQETEAAEKSA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0035254 (glutamate receptor binding), GO:0035255 (ionotropic glutamate receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0051641 (cellular localization), GO:0023056 (positive regulation of signaling), GO:0031503 (protein-containing complex localization), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0007154 (cell communication), GO:0033036 (macromolecule localization), GO:0048522 (positive regulation of cellular process), GO:0048167 (regulation of synaptic plasticity), GO:0099536 (synaptic signaling), GO:0099637 (neurotransmitter receptor transport), GO:0046907 (intracellular transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0001919 (regulation of receptor recycling), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0099177 (regulation of trans-synaptic signaling), GO:0045184 (establishment of protein localization), GO:0001921 (positive regulation of receptor recycling), GO:0071705 (nitrogen compound transport), GO:0016197 (endosomal transport), GO:0015031 (protein transport), GO:0050804 (modulation of chemical synaptic transmission), GO:0099537 (trans-synaptic signaling), GO:0071702 (organic substance transport), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:1900271 (regulation of long-term synaptic potentiation), GO:0098916 (anterograde trans-synaptic signaling), GO:0007268 (chemical synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0030054 (cell junction), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0030133 (transport vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0098978 (glutamatergic synapse), GO:0097708 (intracellular vesicle)