lokahq/bioreason-rl huggingface dataset:
Protein: Muscarinic acetylcholine receptor (A0A8M9PNY8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover
Subcellular location: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR001183: Muscarinic acetylcholine receptor M3 (family) [278-592]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [70-565]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [85-550]
- IPR000995: Muscarinic acetylcholine receptor family (family) [70-567]
Sequence:
MDSNSTELGHFSPSDTLGVGMYPASTLWPLLQNTSLVNLTAVFKLNGSNAEAEGQSYDPLGGHSLWQVILIVVFTGLLSLITIIGNILVMVSFKVNRQLKTVNNYFLLSLAVADLIIGVISMNLYTAYIVMGQWAMGNWACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWFVSLILWAPAILFWQYFVGQRTVPQDKCYIQFLSEPIITFCTAMAAFYLPVTIMSVLYWRIYKETENRSRELAGLQGSGGRFGGVERPRFHLHATRGSSRSCSSFELGQPGHKKASVHSLSGRFHCWGWKSGGSDKSGPNREADQSSSDSWNNNDAGLSADHSGSSDEDESAPSTTRAIFSIVLSLPGVRAAVNSQVTSCEELDTEEDPLRSAEEKDSRDGSISRSVTNGNKRFVGGMSKVQSMSAIQPTTDTTTDSTNTTIKSPSAPITFKEAALAKRFAARARTQITKRKRMSLIKEKKAAQTLSAILFAFIITWTPYNIMVLVNTFCNGCIPENLWALGYWLCYVNSTVNPMCYALCNKTFRSTFKMILLCRWDQKKSKPSFPQRQAVRFHRPIPTDST
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0030594 (neurotransmitter receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0099528 (G protein-coupled neurotransmitter receptor activity), GO:0015464 (acetylcholine receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0098960 (postsynaptic neurotransmitter receptor activity), GO:0016907 (G protein-coupled acetylcholine receptor activity), GO:0008227 (G protein-coupled amine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0071875 (adrenergic receptor signaling pathway), GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: TEA domain family member 1a (A0A8M3B730)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
- IPR050937: TEC1/TEAD Transcription Factor (family) [3-422]
- IPR041086: YAP binding domain (domain) [210-419]
- IPR016361: Transcriptional enhancer factor, metazoa (family) [1-422]
- IPR038096: TEA/ATTS domain superfamily (homologous_superfamily) [27-108]
- IPR000818: TEA/ATTS domain (domain) [26-104]
Sequence:
MDPSSWSGSESAGEDIERMSDSADKPMDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREFHSKLKDHTVKNDAINRMGGISSAQIVSATAIHSRLGLAGLPRSALPGATGIWQVSTGQPGSSQDVKPFSQQNYPIQTTTAIAAYESSTALSAAVPPWHGRSIGTSKLRLVEFSAFLEHQRDPDLYNKHLFVHIGQTNYSYSDALLETVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQEDSGSFYGVTSQYESSENMTITCSTKVCSFGKQVVEKVETEYARFENGRFVYKISRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVSNRETQETLLCMACVFEVSNSEHGAQHHIYRLVKD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016043 (cellular component organization), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0048880 (sensory system development), GO:0032990 (cell part morphogenesis), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0046530 (photoreceptor cell differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0150063 (visual system development), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0005667 (transcription regulator complex)
Protein: Angiomotin (A0A8M2BL72)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction
InterPro domains:
- IPR009114: Angiomotin (family) [538-829]
- IPR051747: Angiomotin-like (family) [59-1009]
- IPR024646: Angiomotin, C-terminal (domain) [654-855]
Sequence:
MFRKKASSSLRMRGISENNRRSVDRARSSSFHEVGRSRDLEMRAAASVSEDTSANNSGGSGHTVLQRLLQEQMRYGEGRNYLALQQQQQQGPVSGYPGPGSPADEHSMVPHIARQEPQGQELQVDSGMEKLSTRTAGGGGGSGGTGSLGGSCVSGQMQNPEDLPTYDQAKVQSQYFRGHQPQQPQPQMPPTVGAAFYVTGVTNSKVRPPEGRSTVQRMNGGKVHQDDGLKDLKQGHVRSLSERLMQLSLATSGVKAHAPVTSSPLSPQLPPPGLPGDYYKPTGPPHRGPPPDYPFKGMPSPPKQQQHHQPQHQEPGHFHPDHRGTSQPARTDIPHVRYQPPPEYGSFRSSKESSSHSQRSVHHHSPSSSVTSGGSLSRAQSSTLSSILAASHALPPMGHSGEPPFPIGARSSQGPGSHQGDPYGPGHPPHQRSHVFPHDHYGSAPRGLHMLQHQYHQQGPQQQQQQSPAQHYSHPLSMQGDPYAMLARAQQMVDMLSEENRLLKQELEVCGEKVSKLQKMETEIQMVSEAYENLAKSSTKREALEKTMRNKLEMEVRRVHDFNRDLRERMETANKQLAAKECEGTEDNRKTISQLLVQVKENQREKEKLEIELNSLRSTTEDQRRHIEIRDQALNNAQAKVVKLEEELKKKQVYVEKVERMQQALAQLQAACEKREQLEHRLRTRLERELESLRMQQRQGGSQSTVGPEFSTAALMEHLREKEERILALEADMTKWEQKYLEESVMRQFALDAAASVATQRDTSSAIISHSPSSSYDTSVEARIQKEEEEILMANRRCLDMESRIKNLHAQIIEKDAMIKVLHQRSRKEPASKLDTPAMRPSKSLMSIATGTGGSSGSGLLSHSLGLSGSSPITEERREDRSWKGSLGVLLGPEFRGDSLRTESISSSPSPVLPSTPMPLATHSKTGSRDSCTQTEKSQENSKPSTPALQNVPGPSRISSPSPVYIPDRIADVPVFHSSTLERRAPVQSLPPASVAAQDMDSDMVEILI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0090130 (tissue migration), GO:0007163 (establishment or maintenance of cell polarity), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0090132 (epithelium migration), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0010631 (epithelial cell migration), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0001667 (ameboidal-type cell migration), GO:0043542 (endothelial cell migration), GO:0043534 (blood vessel endothelial cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0043229 (intracellular organelle), GO:0070161 (anchoring junction), GO:0005938 (cell cortex), GO:0043228 (non-membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0099512 (supramolecular fiber), GO:0005911 (cell-cell junction), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber)
Protein: Nuclear transcription factor Y subunit gamma (A0A8M3B3Q2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors
Subcellular location: Nucleus
InterPro domains:
- IPR050568: Transcription/DNA replication regulator (family) [11-171]
- IPR009072: Histone-fold (homologous_superfamily) [8-118]
- IPR007125: Core Histone H2A/H2B/H3 domain (domain) [26-103]
Sequence:
MSADSFGAGGSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDDLKPPKRQEEVRQSVAPTEPVQYYFTLAQQPSAVQVQGQQQGQQVSAPTATTLQPGQIIIAQPQQGQSAPVTMQVGEGQQVQIVQAAAQGQAQAQTAQPAGQTMQVMQQIITNTGEIQQIPVQLNTGQLQYIRLAQPVSGTQVVQGQIQTLAANTQQLSQTEVQQGQQQFNQFTDGQQLYQIQQVTMPAGQELTQPMFIQSTNQTADGQVTTQVSAD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060041 (retina development in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0005667 (transcription regulator complex)
Protein: Nociceptin receptor (Q7T3Q4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin
Subcellular location: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle
InterPro domains:
- IPR001420: X opioid receptor (family) [99-361]
- IPR001418: Opioid receptor (family) [70-323]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [45-327]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [60-312]
Sequence:
MEFPNDSIGFTDPRHFHLYNESLFQNNFSTFNESDSFFPKGFKITIAVVYMIVCVVGLVGNCLVMYVIIRYTKMKTATNIYIFNLALADALVLATLPFQGTDVFLGFWPFGNALCKVVVSIDYYNMFTSVFTLTVMSMDRYVAVCHPVKALDMRTPHKAKVVNICVWVLASAIGVPAMVLGDVEQDNGESIECILVLPDPRSYWDPVFGTCVFLLSFLIPVAIISVCYSLMVKRLRSVRILSGSKEKDRNLRRITRMVLVVVAAFVVCWTPIQIMALAQSLGFNLASVQTVVFMHFCIALGYVNSSLNPVLYAFLDENFKRCFREFCHPSRFGIDAQQSGRMRHITREVAFNCKTTDGNSNPA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0042277 (peptide binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0042923 (neuropeptide binding), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Tyrosine-protein kinase receptor (A0A0H2UKW5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein
InterPro domains:
- IPR020777: Growth factor receptor NTRK (family) [98-377]
- IPR007110: Immunoglobulin-like domain (domain) [209-299]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [526-798]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [210-409]
- IPR031635: Growth factor receptor NTRK, leucine rich repeat C-terminal (domain) [163-207]
- IPR003599: Immunoglobulin domain subtype (domain) [215-391]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [212-398]
- IPR002011: Tyrosine-protein kinase, receptor class II, conserved site (conserved_site) [691-699]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [527-798]
- IPR013151: Immunoglobulin-like beta-sandwich domain (domain) [217-295]
- IPR017441: Protein kinase, ATP binding site (binding_site) [532-560]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [663-675]
- IPR013098: Immunoglobulin I-set (domain) [321-390]
- IPR050122: Receptor Tyrosine Kinase (family) [220-798]
- IPR003598: Immunoglobulin subtype 2 (domain) [221-290]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [501-799]
- IPR001611: Leucine-rich repeat (repeat) [104-159]
- IPR000719: Protein kinase domain (domain) [526-808]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [33-197]
Sequence:
MDVWLCSAVPVFTWRLFFLSSIFQGYWSSMLDCPPTCSCSPTEIYCNKSDVGNFFPLLALQESAGNGSNNNDIEELFRNITSIHIENWTGLQILRDVDMELYTGLQRLTIINCNLRQIQPRAFSRNPHLRYINLSRNPLASLSWQLFQHLQLVELRLEGVVFDCGCKIRWIQLWRLRGEAGLHTQQLYCKDGASKISLRSMSIAHCDLQDISVAHSNLTVLEGGNVTLSCNGSGSPVPEVDWAVKGLHSINTHQSTVYLPNTHSINLTLVNVSRDDNGFVLTCISENVVGMNNVSLQLSVLFPPVILKLDEPERRHHTCIEFTVRGFPHPTLHWFYKGREILQSEYIRMEMDYYKDYLEGCLTFENPTHYDNGNYTLVATNSLGSVSKTVFGHFLDPPFMEDDAPPPEDEGKRPEDSFGMSIAVGLAGFGCVFLIVIFVLINKYSRRNKFGIKGPVAVISGEEDSASPLHHVNHGIVTPCSLDAGPDAVVIGMSRIPVIENPQYFRHGHNCNKPTTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKTLKDPTLTARKDFQREAELLTNLQHEHIVKFYGVCVDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPMQSNGELGLSQMLHIATQIAAGMVYLSSQHFVHRDLATRNCLVGNGLLVKIGDFGMSRDIYSSDYYRVGGHTMLPIRWMPPESIMYRKFSTESDVWSFGVIMWEIFTYGKQPWFHLSNNEVIECITQGRVLDRPRLCPKEVYDLMLGCWQREPQQRLNIKDIQKVLYALGKATPVYLDILG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Sulfurtransferase (A4QP04)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Mitochondrion
InterPro domains:
- IPR045078: Sulfurtransferase TST/MPST-like (family) [4-294]
- IPR001307: Thiosulphate sulfurtransferase, conserved site (conserved_site) [47-278]
- IPR001763: Rhodanese-like domain (domain) [13-287]
- IPR036873: Rhodanese-like domain superfamily (homologous_superfamily) [2-296]
Sequence:
MAAQTRALVAARWLADAVKSNRVGPNLRILDASWYLPKMKRNPRAEFEQTHIPGASFFDIDECCDKSSEFDHMLPTKGEFADYVGNLGIGNNTHVVVYDASDFGSFSAPRVWWMFRVFGHSSVSVLDGGFKNWLKEGHPVSQQYSKPAPVDFNASFKESWVKTYEDVLNNIKTKEFQVVDARANGRFRGVEPEPRANTEPGHIPASLNMPFPSFMDPESGLERPVEELTKLFQQAGVDLQKPFWVTCGSGVTACHIALAAHLCGHPGVSLYDGAWSEWFTKAAPEHIISEGKGKQP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016782 (transferase activity, transferring sulphur-containing groups), GO:0016783 (sulfurtransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Opioid receptor, delta 1b (B3DH72)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [71-324]
- IPR001418: Opioid receptor (family) [81-335]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [56-332]
Sequence:
MEPPTVTVSDFSERYPLFLHNSSFLEEPAGLLSNWSGGSSELKAVRGSSAVAIAVSITALYSVICVVGLVGNVLVMYGVVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMGTWPFGELLCKVVIAIDYYNMFTSIFTLTMMSVDRYIAVCHPVRALDFRTPVKAKIINICVWILSSAVGFPVMVMAVTKELDSGKTICMLKFPDPEWYWDTVTKICVFIFAFVFPVLVITVCYGLMILRLKSVRLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFIIVKTVVEIDQKNLLVVACWHLCIALGYMNSSLNPVLYAFLDENFKRCFREFCLPFRTRIEQNSFSKARSVIREPISVCAKSESIKQPT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Epithelial cell-transforming 2 (A0A8M2B2N3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR011993: PH-like domain superfamily (homologous_superfamily) [701-828]
- IPR000219: Dbl homology domain (domain) [486-675]
- IPR001357: BRCT domain (domain) [173-357]
- IPR049396: ECT2, BRCT0 domain (domain) [94-174]
- IPR036420: BRCT domain superfamily (homologous_superfamily) [46-360]
- IPR001331: Guanine-nucleotide dissociation stimulator, CDC24, conserved site (conserved_site) [623-648]
- IPR026817: Guanine nucleotide exchange factor Ect2 (family) [28-943]
- IPR049395: ECT2, PH domain (domain) [701-826]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [461-694]
Sequence:
MADSSILTLGPGRSILVDSSVYDSRMAETSKEQYFIGLHSDETEGVLPRVETRVVLVGEACKMAELEKALQAITIMEVPVVKIKEGQPGTEAREKLIKSIVNMDLNTPCIKTDNVCDFGDGENCEFETVFVLKDFQAPEYSFLYKNDSRILGPPAVMHCANKGEPLPFSSRPLYSMTMLNLSLCFTGFRKKDEVVALVNLVHHMGGTIRKDFDSAKVTHLIARSTHGEKYRLAVCMGTPILTPDWIRKAWEHRDDINFHAGNELFRTEFKVPPFQDCVLSFLGFSEEEKNNMEERTQKHGGRFQAVGDERCTHLVVEENSIKELPFTPSKRLYVVKQEWFWGSIQMDARAGESMYSYEKPESPAMKKAVSLLSLTTPNSGRKRRRLRETLAQLTKETEISPFPPRKRPSAEHSLSMGSLLDISNTPDTKSSGERRCRRSSGRRRSSRQSRSERLQRTSTPVCRHEDQTENAKIPKSSTPALPKQSARWQVSKELYQTESNYVDILATVLQLFKYPLEKEGQVGGPILAQEEIKTIFGSIPDIYEVHTRIKADLEELVMNWSEERSVGDIILKYSGELVKAYPPFVNFFEMSKETIVRCERQKPRFHAFLKINQSKPECGRQTLVELLIRPVQRLPSVALLLNDIKKHTSDDNPDKLTLEKAIESLKEVMTHINEDKRKTEGQKQIFDVVYEVDGCPANLLSSHRSLVHRVETIALGDKPCDRGEHVTLFLFNDCLEIARKRHKVITNFRSPLGQTRPPAQLKHITLMPLSQIRRVLDIQDTEECQNAFALVVRPPTEQENLLFSFQLTAEDTLKTTWLRTLCRQVANTICRADAEDLIQSTDPDSVQVSTKDMDSTLSRASRAIKKTSKKVTRAFSFTKTPKRVLQRAFMANGTPDERSPCPDADRMSRMSSSSTLAMSRSASTFSLTGSIKSAVVQRSNSLDHAPRPRVPVCVRTPCSPERADEPAAPKSQLRPSILSLPAVQPVAKCRDLLAPPEPGRRLPGSPRRETLL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0046983 (protein dimerization activity), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007049 (cell cycle), GO:0022402 (cell cycle process), GO:0051301 (cell division), GO:0032506 (cytokinetic process), GO:0000910 (cytokinesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)