Protein: Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1) (3-OST-3B) (Heparan sulfate 3-O-sulfotransferase 3B1) (m3-OST-3B) (Q9QZS6)
Organism: Mus musculus (Mouse)
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:10520990}; Single-pass type II membrane protein {ECO:0000305|PubMed:10520990}.
InterPro domains:
- IPR000863: Sulfotransferase domain (domain) [138-378]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [126-390]
- IPR037359: Heparan sulfate sulfotransferase (family) [29-390]
Sequence:
MGQRLSGGRSCLDVPGRFLPQPPPPPPPVRRKLALLFAMLCIWLYMFLYSCAGSCTAAPGLLLLGSGSRATHAQPALVTAPNETSPKMPFRAPPANSLAAGKDKTVGAGSQEEQSPEAPDSPSPISSFFSGAGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYHKGLAWYRDLMPRTLKGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPSFESLTFRNRSAGLIDTSWSAIQIGLYAKHLEPWLRHFPLGQMLFVSGERLVSDPAGELRRVQDFLGLKRIITDKHFYFNQTKGFPCLKKAEGSGKPHCLGKTKGRAHPTIAREVLRQLRDFYRPFNRKFYQMTGRDFGWD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016782 (transferase activity, transferring sulphur-containing groups), GO:0008146 (sulfotransferase activity), GO:0034483 (heparan sulfate sulfotransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0009653 (anatomical structure morphogenesis), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0001763 (morphogenesis of a branching structure), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0035295 (tube development), GO:0048729 (tissue morphogenesis), GO:0009887 (animal organ morphogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0009888 (tissue development), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0072028 (nephron morphogenesis), GO:0061138 (morphogenesis of a branching epithelium), GO:0044249 (cellular biosynthetic process), GO:0072006 (nephron development), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0035239 (tube morphogenesis), GO:0072001 (renal system development), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0060562 (epithelial tube morphogenesis), GO:0072009 (nephron epithelium development), GO:0061326 (renal tubule development), GO:0009100 (glycoprotein metabolic process), GO:0044272 (sulfur compound biosynthetic process), GO:0072088 (nephron epithelium morphogenesis), GO:0072164 (mesonephric tubule development), GO:0002009 (morphogenesis of an epithelium), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0060429 (epithelium development), GO:0001822 (kidney development), GO:0060993 (kidney morphogenesis), GO:0048754 (branching morphogenesis of an epithelial tube), GO:0061333 (renal tubule morphogenesis), GO:0001658 (branching involved in ureteric bud morphogenesis), GO:0072080 (nephron tubule development), GO:0015012 (heparan sulfate proteoglycan biosynthetic process), GO:0006029 (proteoglycan metabolic process), GO:0001823 (mesonephros development), GO:0001657 (ureteric bud development), GO:0072073 (kidney epithelium development), GO:0009101 (glycoprotein biosynthetic process), GO:0072171 (mesonephric tubule morphogenesis), GO:0072078 (nephron tubule morphogenesis), GO:0060675 (ureteric bud morphogenesis), GO:0072163 (mesonephric epithelium development), GO:0030166 (proteoglycan biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)