lokahq/bioreason-rl huggingface dataset:
Protein: LD10379p (Q7YU00)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
InterPro domains:
- IPR036020: WW domain superfamily (homologous_superfamily) [42-76]
- IPR001202: WW domain (domain) [50-77]
Sequence:
MSSSCERIEWVEIIEPRTKEHMYANLTTGECVWDPPEDVPIKRTDSSQWWELFDTNTQRFYYYNAATQKTVWHRPSKCDIIPLAKLQTLKQNTDPSERREQTTPQKQQQQQVQHASQQQQHPSPMSGPNKKGRGQQRISGGNGTVASSEEKLTSSEVISSPRGRQSFRVSTGDSSRSMDMQQQHPQGYASRRSQDSCNQYKESGKSSDSSLSSAHGYRRFNDSGVPVSGHPDNLRLGSLQKQQRGGGKDNGAFEMLQESTSSHNLPHGSTSTSSSYAGGSGYGDKYFDHQLLPNHLQGYSSKSSDIASPTHSIHTPQSQKKKMSPDAAPAAQYNYAQQQHQQRSAQRSGGGAAGTGAPAGKSYGGDREYKVSLARSGSFMSSSINPAAAGHHSKSYRKSSAEAANGGAASDDSMHEKYFKSVENTPLSRRRHTTNATKSGGGASGSNTATSTAGSGSSSHKKHSSDSSPQSPISPQTKSSRQAKTSATSTVPQLQHSPRLQEPSHSLDLLSLERISLGKSGPISPGGGTENLGLLTHSSRGSNDSARQRQKSNNSSANRSQSHHYPGQSSLRHSASSSLDKRGYHVGGGSGDGRGVTGGEKRRSKQHHYQQQADNSDVEYDNGNTSPLYTNWDQEMPHLLPLKHYIIEQAKLSGRYEYRGGDGGDSDSYHSDSQSEHSLSGHEPDNEDSDGGSDTHGGYLEHNYGMIDDYANMGDSVSYYAYMYPPHDPAGREDISENVEAVLEGIGGNATEPSAPTATAPKPKPRYQISYYDTVSHSPSAGSGYHGQQLYSNTPPYSGARSWTSRSTAVTAPPAAVAPGTERH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0003008 (system process), GO:0007610 (behavior), GO:0016043 (cellular component organization), GO:0050877 (nervous system process), GO:0034330 (cell junction organization), GO:0007600 (sensory perception), GO:0050808 (synapse organization), GO:0050954 (sensory perception of mechanical stimulus), GO:0050975 (sensory perception of touch), GO:0007605 (sensory perception of sound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)
Protein: Dof zinc finger protein DOF5.4 (AtDOF5.4) (OBF-binding protein 4) (Q8LDR0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence. Enhances the DNA binding of OBF transcription factors to OCS elements (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
InterPro domains:
- IPR045174: Dof zinc finger protein (family) [43-195]
- IPR003851: Zinc finger, Dof-type (domain) [49-105]
Sequence:
MQDIHDFSMNGVGGGGGGGGRFFGGGIGGGGGGDRRMRAHQNNILNHHQSLKCPRCNSLNTKFCYYNNYNLSQPRHFCKNCRRYWTKGGVLRNVPVGGGCRKAKRSKTKQVPSSSSADKPTTTQDDHHVEEKSSTGSHSSSESSSLTASNSTTVAAVSVTAAAEVASSVIPGFDMPNMKIYGNGIEWSTLLGQGSSAGGVFSEIGGFPAVSAIETTPFGFGGKFVNQDDHLKLEGETVQQQQFGDRTAQVEFQGRSSDPNMGFEPLDWGSGGGDQTLFDLTSTVDHAYWSQSQWTSSDQDQSGLYLP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Cadherin-related neural recepter 5 (O88192)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
InterPro domains:
- IPR050174: Protocadherin/Cadherin-related Cell Adhesion (family) [4-740]
- IPR002126: Cadherin-like (domain) [9-642]
- IPR031904: Cadherin, C-terminal catenin-binding domain (domain) [764-897]
- IPR013164: Cadherin, N-terminal (domain) [4-75]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [91-633]
- IPR020894: Cadherin conserved site (conserved_site) [194-527]
Sequence:
FSSKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSLECSIHLEVIVDRPLQVFHVEVEVRDINDNPPVFPETNKNIVIAESRPPETRFPLDGASDADIGVNSALTYRLDPSDYFALDTQNNRERTSSLSLVLKKSLDREEIQEYSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFDRFVYKVKVLEDALNGTLVINLNATDPDEGINGDIIYSFRRPVSPAVVHAFNIDSNSGEVRTKGLLDFEEIKLYEIPVEAVDKGNIPMTGHCTLLVELLDVNDNAPEVTITSLSLPVREDAQPSTVIALVSVSDRDSGDNGQVTCSLTPHLPFKLVSTFKNYYSLVLDSALDRETTADYKVVVTARDRGSPSLWSTASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGERLLSSYVSVHAESGKVFALQPLDHEELELLQFQVSARDAGVPSLGSNVTLQVFVLDENDNAPTLLPHRAVGAVGTVSELVPRSVGSGHVVAKVRAVDADSGYNAWLSYELQLAAGGMRSPFRVGLYTGEISTTRSLDEADAPRQRLLVLVKDHGEPALTATATVLVSLVENGQAPKISSLASESTASSEASLVTVNVYLIIAICAVSSLLVITLLLYTALRCSARSTDGACAPGKPMLVCSSAVGSWSYSQQRRQRVCSGEGPPKTDLMAFSPSLPPVLGSAEDTCQRERQVEHLKEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0098609 (cell-cell adhesion), GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules), GO:0007156 (homophilic cell adhesion via plasma membrane adhesion molecules)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Gap junction protein (A7VKB2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell junction, gap junction {ECO:0000256|ARBA:ARBA00004610}. Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}.
InterPro domains:
- IPR000500: Connexin (family) [1-317]
- IPR017990: Connexin, conserved site (conserved_site) [54-205]
- IPR019570: Connexin, cysteine-rich domain (domain) [167-233]
- IPR038359: Connexin, N-terminal domain superfamily (homologous_superfamily) [2-243]
- IPR013092: Connexin, N-terminal (domain) [3-235]
Sequence:
MTEWTLLKRLLDAVHQHSTMIGRLWLTIMVIFRLLIVAVATEDVYTDEQEMFVCNTLQPGCPNVCYDAFAPISQPRFWVFQIITVSTPSLCFIIYTWHNLSKQPEGEQIKEALERSCDSESCSIKSHKHINPSLEGVTNQKPSQASKTSSGVLSKYYIFHVCFRTILEVAFVVAQWLLFGFRVPAHFVCTSSPCMQSVDCYVSRPTEKTVFLIFMFCVGVFCIFLNFLELNHLAWKMIKRSVLVKDGSWNGYGAINQDSQSIASLTFRDVTSTTSLPTLDLVVDHQPDWTCAANCSTKKDNRGTQSKPKTNRKAKQRSTEVWI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015267 (channel activity), GO:0022829 (wide pore channel activity), GO:0005243 (gap junction channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0034330 (cell junction organization), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0022607 (cellular component assembly), GO:0007416 (synapse assembly), GO:0048699 (generation of neurons), GO:0050808 (synapse organization), GO:0120036 (plasma membrane bounded cell projection organization), GO:0034329 (cell junction assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005886 (plasma membrane), GO:0005911 (cell-cell junction), GO:0005921 (gap junction)
Protein: Thialysine N-epsilon-acetyltransferase (EC 2.3.1.-) (O17731)
Organism: Caenorhabditis elegans
Function: Catalyzes the N-acetylation of the amino acid thialysine (S-(2-aminoethyl)-L-cysteine), a L-lysine analog with the 4-methylene group substituted with a sulfur. Substrate specificity: thialysine > O-(2-aminoethyl)-L-serine > S-(2-aminoethyl)-D,L-homocysteine. Does not act on polyamines, such as spermidine and spermine, nor on diamines putrescine and cadaverine.
InterPro domains:
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [3-144]
- IPR000182: GNAT domain (domain) [4-159]
- IPR051016: Diverse Substrate Acetyltransferase (family) [3-160]
Sequence:
MKNFEIVTVTPDHAEQLISMIHELAEFEKMKSSVVNTAEKLRKDIENKAVHGFIAFIGEEPAGMNLFYYAYSTWVGQYLHMEDLYIRPQFRRMGLARTLWKKLAELARDKGIVRLEWAVLDWNKNAIALYDTVDYVNLTKSEGWFTFRMDGAAINKFADE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0009308 (amine metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006576 (biogenic amine metabolic process), GO:0009310 (amine catabolic process), GO:0042402 (cellular biogenic amine catabolic process), GO:0006595 (polyamine metabolic process), GO:0008216 (spermidine metabolic process), GO:0006598 (polyamine catabolic process), GO:0008215 (spermine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Brevinin-1DYb (Brevinin-1CDYb) (P0C5W7)
Organism: Rana dybowskii (Dybovsky's frog) (Korean brown frog)
Function: Antimicrobial peptide. Has low activity against the Gram-positive bacterium S.aureus and the Gram-negative bacterium E.coli (MIC<15 uM). Has a strong hemolytic activity.
Subcellular location: Secreted {ECO:0000269|PubMed:17688900}.
InterPro domains:
- IPR004275: Frog antimicrobial peptide, propeptide (domain) [2-45]
- IPR012520: Frog antimicrobial peptide, brevinin-1 type (domain) [47-66]
Sequence:
MFTLKKSLLLLFFLGTISLSLCEEERNAEEERRDYPEERDVEVEKRFLSLALAALPKLFCLIFKKC
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium), GO:0050830 (defense response to Gram-positive bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Methoxy mycolic acid synthase MmaA3 (EC 2.1.1.-) (Mycolic acid methyltransferase) (MA-MT) (S-adenosylmethionine-dependent methyltransferase) (AdoMet-MT) (SAM-MT) (A5U028)
Organism: Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Function: Involved in the biosynthesis of methoxymycolic acid. It catalyzes the O-methylation of the hydroxy group of the hydroxymycolate to form a methyl ether.
InterPro domains:
- IPR050723: Cyclopropane Fatty Acid Synthase/Methyltransferase (family) [7-293]
- IPR047672: Cyclopropane mycolic acid synthase, actinobacteria (family) [12-293]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [2-293]
- IPR003333: Cyclopropane mycolic acid synthase (family) [2-293]
Sequence:
MSDNSTGTTKSRSNVDDVQAHYDLSDAFFALFQDPTRTYSCAYFERDDMTLHEAQVAKLDLTLGKLGLEPGMTLLDVGCGWGSVMKRAVERYDVNVVGLTLSKNQHAYCQQVLDKVDTNRSHRVLLSDWANFSEPVDRIVTIEAIEHFGFERYDDFFKFAYNAMPADGVMLLHSITGLHVKQVIERGIPLTMEMAKFIRFIVTDIFPGGRLPTIETIEEHVTKAGFTITDIQSLQPHFARTLDLWAEALQAHKDEAIEIQSAEVYERYMKYLTGCAKAFRMGYIDCNQFTLAK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008168 (methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0008610 (lipid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: SKP1-like protein 21 (AtSK21) (Q8LF97)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
InterPro domains:
- IPR001232: S-phase kinase-associated protein 1-like (family) [15-116]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [12-162]
- IPR036296: SKP1-like, dimerisation domain superfamily (homologous_superfamily) [92-159]
- IPR016897: S-phase kinase-associated protein 1 (family) [13-156]
- IPR016072: SKP1 component, dimerisation (domain) [117-155]
Sequence:
MSEGEMAIIKPEMMKSYIWLETADGSIQQVEQEVAMFCPMICQEVIQKGVGSSKNYAISLPQRVNPAMLSLIFDYCRFHQVPGRSNKERKVYDEKFIRMDTKRLCELTSAADSLQLKPLVDLTSRALARIIEGKTPEEIREIFHLPDDLTEEEKLEPLKNTMDDPRIRLLNRLYAKKRKELKEREKLKSVEVEEHVDERSVDDLLSFINGRDPKVVKTSKSKKKNKKRKEQKNGSSNGTCEALEKDLHNLDSKSQSAEIVDNTASCLGDVSNLPSMEDDIFTPKTEFEDGYIDDEIDPALKELLDREVEDFARRLNSSWVLSIGQERQPVNFSINGNGTSRRLTGPAAGHK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0009755 (hormone-mediated signaling pathway), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0009725 (response to hormone), GO:0032870 (cellular response to hormone stimulus), GO:0071310 (cellular response to organic substance), GO:1901701 (cellular response to oxygen-containing compound), GO:0033993 (response to lipid), GO:0070542 (response to fatty acid), GO:0009753 (response to jasmonic acid), GO:0009867 (jasmonic acid mediated signaling pathway), GO:0071398 (cellular response to fatty acid), GO:0071395 (cellular response to jasmonic acid stimulus), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0019005 (SCF ubiquitin ligase complex)
Protein: Disease resistance protein (TIR-NBS class) (F4IF04)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
InterPro domains:
- IPR035897: Toll/interleukin-1 receptor homology (TIR) domain superfamily (homologous_superfamily) [28-227]
- IPR000157: Toll/interleukin-1 receptor homology (TIR) domain (domain) [37-228]
- IPR002182: NB-ARC (domain) [255-417]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [228-452]
- IPR044974: Disease resistance protein, plants (family) [38-450]
Sequence:
MNTIFKKLSCFKKKVKSLRIFESRSLSSSSSSSFTPQKFDVFLSFRGKDTRKNFVSFLYKALVSKGIRTFKDDEELERGRPIPPELRQAIKGSRIAVVVVSVTYPASSWCLEELREILKLEKLGLLTVIPIFYEINPSDVRRQSGVVSKQFKKHEKRQSRERVKSWREALTKLASLSGECSKNWEDLSNRFSKFRFLSLFLKGLRLCFSREDDSKLVDGITEKISTKLFSEKPRNDNILIGIDQHMGELYPLFNLNSNEDVQVIGIWGRGSNGRSALASHVYQNIKHHFEAHCFLEDVRRISLHFRDSHLQDELLSNMQGEGLTTKNCHRCLKTIKARLRNKKVLLVANDVDKLEQFDALAEEFSWFGPGSRIIITTQDRQLLISSVVRSVYEVKLLRCYAVRELFRSNAFKERERDDPVGFDQSTYRAMYISGHVFLTLRYIFTLLCDRVNVTPFFYIWMCHLCMDLCTIHLVNYFILKTVHNKFI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0006952 (defense response), GO:0010942 (positive regulation of cell death), GO:0043207 (response to external biotic stimulus), GO:0010941 (regulation of cell death), GO:0009620 (response to fungus), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0050832 (defense response to fungus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Trifunctional (S)-stylopine synthase/(S)-nandinine synthase/(S)-canadine synthase (STS) (EC 1.14.19.64) (EC 1.14.19.68) (EC 1.14.19.73) (Cytochrome P450 719A13) (B1NF19)
Organism: Argemone mexicana (Mexican prickly poppy)
Function: Methylenedioxy bridge-forming cytochrome P450 involved in the biosynthesis of isoquinoline alkaloids. Converts (S)-cheilanthifoline to (S)-stylopine, (S)-scoulerine to (S)-nandinine and (S)-tetrahydrocolumbamine to (S)-canadine. Can be involved in both sanguinarine and berberine biosynthesis. Catalyzes an oxidative reaction that does not incorporate oxygen into the product.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
InterPro domains:
- IPR001128: Cytochrome P450 (family) [49-492]
- IPR002401: Cytochrome P450, E-class, group I (family) [77-471]
- IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [42-504]
- IPR017972: Cytochrome P450, conserved site (conserved_site) [441-450]
Sequence:
MEEKIMTNNSPWILTSSTTTTTTILLSLLFTIFIILRRNKSSSSKMVWPTGPKTLPIIGNMNILGGTALHVVLHNLAKTYGNVMTIWIGSWRPVIVVSDIDRAWEVLVNKSSDYSARDMPEITKLATADWKTISSSDSGPFWTNLRKGLQNVALSPQNLSSQSKFQERDIIKTIQNLKEEAKMNNGIVKPLDHLKKAMVRLISRLIYGQDFDNDEYVEEMHHTIEELIRVSGYARLAEAFYYAKYLPSHKKAVREVLQANQRVQNLVRPLLSLNSPTNTYLHFLRSQNYEDEVIIFAIFEAYLLGVDSTSSTTAWALAYLIREPNVQEKLYEELKNFTNDNDRKMVKFEDLNKLQYLQAVVKETMRMKPIAPLAIPHKACRETSLMGRKVNQGTRVMVNIYALHHNQNVWKEPYKFNPERFLQKNQDGVDGKAMEQSLLPFSAGMRICAGMELGKLQFSFALANLVNAFKWSCVSDGVFPDMSDQLGFVLLMKTPLEAGIVPRM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016717 (oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0019748 (secondary metabolic process), GO:0009058 (biosynthetic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009821 (alkaloid biosynthetic process), GO:0009820 (alkaloid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)