lokahq/bioreason-rl huggingface dataset:
Protein: Germ cell nuclear acidic-1 protein (Germ cell nuclear acidic-1 peptidase) (Q23462)
Organism: Caenorhabditis elegans
Function: May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage. May resolve the topoisomerase II (top-2) DPCs. Limits replication stress and DNA double-strand breaks.
Subcellular location: Chromosome {ECO:0000269|PubMed:31839538}. Note=Localizes on condensed chromosomes in spermatocytes in G2 and M during meiotic prophase (PubMed:31839538). Colocalizes with top-2 on condensed chromosomes during embryonic cell divisions (PubMed:31839538). {ECO:0000269|PubMed:31839538}.
InterPro domains:
- IPR006640: SprT-like (domain) [296-451]
Sequence:
MPTPFRDLHNKSNASASSYETAWSSSFSSRRSTNNDSKSNLKEIKDEPISNLDESISILENNISMMSVSSPTPAYRTPARVIAREAPMTPGDRLLQKIEKEDERDMLRQLYPEMFDSNQKPRQKPKEVKKALKVESLSDYENDDKENVPPCGKPSKEKEEKKQRTKKIVISSDSEDDGNFENYLKTLREKPTEPAKPERKIPVKKDFVVDDDYISEESSEEESEEEEEDVDDEEYRESSPEVEAKISYSDRKQKKRPTDEEEWFLLSLSEKFSGPIHEDAKVYIKETSLRYKKHRESLLTRLQDILVRRIFSAIPSEKLKVIWNARLRKSAGQCRNHSNGNSTVEMSPVVCTTAERVRDTLIHELCHAATWVVDRLHKEGHGPGWKRWGARCSSVFKSLPFIERCHSYEIEAKFFYVCEKDGCDVEIKRQSKSLDTSRKACGRCFGRFILYRYCRRTNTRIRIEDPKAKPVGPILSNSSKPSPPAPRRIVSEHPEGFKEYSEEHYWKYTAQGLKHSDVMGKLLKEFKELKQL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0033554 (cellular response to stress), GO:0006974 (cellular response to DNA damage stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1) (P30837)
Organism: Homo sapiens (Human)
Function: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
Subcellular location: Mitochondrion matrix.
InterPro domains:
- IPR016160: Aldehyde dehydrogenase, cysteine active site (conserved_site) [312-323]
- IPR015590: Aldehyde dehydrogenase domain (domain) [45-508]
- IPR016161: Aldehyde/histidinol dehydrogenase (homologous_superfamily) [29-512]
- IPR016162: Aldehyde dehydrogenase, N-terminal (homologous_superfamily) [51-508]
- IPR029510: Aldehyde dehydrogenase, glutamic acid active site (conserved_site) [284-291]
- IPR016163: Aldehyde dehydrogenase, C-terminal (homologous_superfamily) [290-479]
Sequence:
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor), GO:0004030 (aldehyde dehydrogenase [NAD(P)+] activity), GO:0004029 (aldehyde dehydrogenase (NAD+) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006066 (alcohol metabolic process), GO:0006081 (cellular aldehyde metabolic process), GO:0044248 (cellular catabolic process), GO:0005975 (carbohydrate metabolic process), GO:0046185 (aldehyde catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Pre-mRNA-splicing factor PRP11 (Q07350)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for addition of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly.
Subcellular location: Nucleus {ECO:0000250}.
InterPro domains:
- IPR052092: Splicing Factor 3A Subunit 2 (family) [1-264]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [56-94]
- IPR003604: Matrin/U1-C-like, C2H2-type zinc finger (domain) [63-97]
- IPR013087: Zinc finger C2H2-type (domain) [67-90]
- IPR031781: SF3A2 domain (domain) [135-250]
Sequence:
MNYLEGVGSKKGGGGIASESQFNLQRRKEVESLLSKGENVPYTFQDEKDDQVRSNPYIYKNHSGKLVCKLCNTMHMSWSSVERHLGGKKHGLNVLRRGISIEKSSLGREGQTTHDFRQQQKIIEAKQSLKNNGTIPVCKIATVKNPKNGSVGLAIQVNYSSEVKENSVDSDDKAKVPPLIRIVSGLELSDTKQKGKKFLVIAYEPFENIAIELPPNEILFSENNDMDNNNDGVDELNKKCTFWDAISKLYYVQFFFKQAEQEQADV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0043229 (intracellular organelle), GO:0005681 (spliceosomal complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005684 (U2-type spliceosomal complex), GO:0005634 (nucleus)
Protein: Orthopedia homeobox a (F6NUE7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
InterPro domains:
- IPR001356: Homeodomain (domain) [99-163]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [95-162]
- IPR003654: OAR domain (domain) [297-314]
- IPR000047: Helix-turn-helix motif (conserved_site) [130-155]
- IPR017970: Homeobox, conserved site (conserved_site) [134-157]
- IPR051895: Orthopedia Homeobox (family) [1-319]
Sequence:
MLSHADLLDARLGMKDAAAELLGHREALKCRLGGGGTDPVHPGDLAPVSDAVEGATLLPGDDINSAGSNPPGVAVNSKDQEKQQQQQQNPTQSSSQQSQKQKRHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRRAKWKKRKKTTNVFRAPGTLLPTHHGLPQFPSAAAAAAAMGDSLCSFHANDTRWAAAGMPGVSQLQLPPALGRQQAMAQSLSQCSLGAGPPPNSMSLSNMSSNGSGLQSHLYQPTFPGMVPASLSGPTNVTGSPQLCSSPDTDVWRGTSIASLRRKALEHTVSMSFT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0035176 (social behavior), GO:0007610 (behavior), GO:0021536 (diencephalon development), GO:0060322 (head development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0009314 (response to radiation), GO:0030900 (forebrain development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0021517 (ventral spinal cord development), GO:0007632 (visual behavior), GO:0007420 (brain development), GO:0021510 (spinal cord development), GO:0022008 (neurogenesis), GO:0009416 (response to light stimulus), GO:0021872 (forebrain generation of neurons), GO:0007399 (nervous system development), GO:0021761 (limbic system development), GO:0021522 (spinal cord motor neuron differentiation), GO:0007417 (central nervous system development), GO:0021515 (cell differentiation in spinal cord), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0071542 (dopaminergic neuron differentiation), GO:0021954 (central nervous system neuron development), GO:0048699 (generation of neurons), GO:0021953 (central nervous system neuron differentiation), GO:0021879 (forebrain neuron differentiation), GO:0021884 (forebrain neuron development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Large ribosomal subunit protein mL52 (39S ribosomal protein L52, mitochondrial) (L52mt) (MRP-L52) (Q9D0Y8)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q86TS9}.
InterPro domains:
- IPR034596: Large ribosomal subunit protein mL52 (family) [4-116]
Sequence:
MAALGTWLSSVRRLHCSVVARAGGQWRLQQGLAANPSGYGPLTELPDWSFADGRPAPPMKGQLRRKAQREKLARRVVLLTQEMDAGIQAWKLRQQKLQEERKKEHDLKPKGTLLRSPLPNQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0003735 (structural constituent of ribosome)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Large ribosomal subunit protein uL29x (60S ribosomal protein L35-3) (Q9M3D2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
InterPro domains:
- IPR036049: Large ribosomal subunit protein uL29 superfamily (homologous_superfamily) [1-77]
- IPR045059: Large ribosomal subunit protein uL29, eukaryotes (family) [1-123]
- IPR001854: Large ribosomal subunit protein uL29 (family) [4-64]
- IPR018254: Large ribosomal subunit protein uL29, conserved site (conserved_site) [43-57]
Sequence:
MARIKVHELRDKSKSDLSTQLKELKAELASLRVAKVTGGAPNKLSKIKVVRKSIAQVLTVSSQKQKSALREAYKNKKLLPLDLRPKKTRAIRRRLTKHQASLKTEREKKKDMYFPIRKYAIKV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0003735 (structural constituent of ribosome), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0009314 (response to radiation), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0009416 (response to light stimulus), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0065003 (protein-containing complex assembly), GO:0042254 (ribosome biogenesis), GO:0022618 (ribonucleoprotein complex assembly), GO:0042273 (ribosomal large subunit biogenesis), GO:0071826 (ribonucleoprotein complex subunit organization), GO:0042255 (ribosome assembly), GO:0140694 (non-membrane-bounded organelle assembly), GO:0000027 (ribosomal large subunit assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0055044 (symplast), GO:0030054 (cell junction), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0043228 (non-membrane-bounded organelle), GO:0044391 (ribosomal subunit), GO:0043233 (organelle lumen), GO:0009506 (plasmodesma), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0022625 (cytosolic large ribosomal subunit), GO:0070013 (intracellular organelle lumen), GO:0015934 (large ribosomal subunit), GO:0005911 (cell-cell junction), GO:0005730 (nucleolus), GO:0005840 (ribosome), GO:0005634 (nucleus), GO:0031981 (nuclear lumen)
Protein: Fibronectin-binding protein (Q93ED6)
Organism: Streptococcus equi subsp. equi
Function: Not known
InterPro domains:
- IPR013552: Thioester domain (domain) [69-199]
- IPR023849: TQXA domain (domain) [130-172]
Sequence:
MKTKSFRKVLTTSATCIVLATSFAGGTLRVWAEQLYYGWNDGTRQSSPYFLYVSPKNAPKRELKDEYVVYCFNKKLYWPDQWESIYSNFNDIRSPYNDLPVYEKKLGYDGIFKQYAPDYKKDISDIASALVAVLSNGYPTNKSQLSTSYHLNNDSSRKVTQLAIWYFSDSLTKEYLKDTGGYNLNDMEKKALDFLISKGEDSKLKSEQSNYSLDIYVYQSGGHDHMKDYQNLLGSTLIPKEPLKPQLGGFSGHNGNGLSGLEGGSSGSQETNEDGKKGLIGFHGGLSGSEGKRDPFQD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0008219 (cell death), GO:0012501 (programmed cell death), GO:0006915 (apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Replication enhancer protein (REn) (Protein AC3) (Protein AL3) (P03563)
Organism: Tomato golden mosaic virus (strain Yellow vein) (TGMV)
Function: Increases viral DNA accumulation. Enhances infectivity and symptom expression (By similarity).
InterPro domains:
- IPR000657: Geminivirus AL3 coat protein (family) [2-120]
Sequence:
MDSRTGEPITVPQAENGVYIWEITNPLYFKIISVEDPLYTNTRIYHLQIRFNHNLRRALDLHKAFLNFQVWTTSTTASGRTYLNRFKYLVMLYLEQLGVICINNVIRAVRFATDRSYITHVLENHSIKYKFY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0016032 (viral process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019058 (viral life cycle), GO:0006807 (nitrogen compound metabolic process), GO:0019079 (viral genome replication), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0039693 (viral DNA genome replication), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0006259 (DNA metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0039687 (viral DNA strand displacement replication), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0071897 (DNA biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0030430 (host cell cytoplasm), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)
Protein: Vacuolar protein sorting-associated protein 35 (O74552)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor vps10. Required to form proper forespore membranes.
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
InterPro domains:
- IPR005378: Vacuolar protein sorting-associated protein 35 (family) [4-834]
- IPR042491: Vacuolar protein sorting-associated protein 35, C-terminal (homologous_superfamily) [505-822]
Sequence:
MNGINTANEEITRSLEESLNICKQSSRLMQRNLQTGRLMDAFRNCSISLVEMRNSALTPKQYYELYMFNMESLRLLGGTLLETHLNGTHNLMDLYELVQYAGSIVPRLYLMITVGSAYLETPNALVREIMNDLLDMCRGVQHPLRGLFLRHYLLTQTRKGLPLGSEDEEDASRKGTVLDSVKFLVINFTEMNKLWVRIQHLGPIKEFSKRTQERNELKVLVGLNLVRLSQLNLDIDTYRDHVLPAIIEQIIECRDSLAQEYLVEVICQAFSDNMHLQTLDTYFGTVIKLSPSVNVTQLVVAMLNRLTDYVQREYESDSSNEDESETVTEKLGDIKINEEVQQKDEQECPGDKVIPPEYAIQEVLWSHVVEVIQSRSGLPLDCIVSILSSILNFFLRCYPYKPQYADRVFQYINEHIINQPSLRSALHERPLQKSLCAILLLPLTYFPSFSYCLELQNFLPVFNAQDPNLRYDIARMIVQKIIEKGHSLSELTEAQELLGFVSVIIEKKGVDSLDDLQNVALMVHYLNNDDPQIQIEILRSLKDTFIKAGENVKYLLPVVVNRCIFLARNFRIFKCMDWAEKVRLLWEFVNTCINVLYKNGDSLELCLALYLSAAEMADQENYPDFAYEFFTQAFSIYEESVLDSELQYQQLLMIIGKLQKTRNFSVDDYDTLITKCTLYASKLLKKPDQCCGIYLASHLWWQVASGEDSRPFQDPKRVLECLQKSLKIADACMDQLTSLKLFINILERYFYYYDQHCESIIAKHISGLIDLTEQNMRSILISSPADLIASDPRAYASSIWEVANVSVIDSLKNHLERATAYAEKRSEDERWSSIFQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0016192 (vesicle-mediated transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport), GO:0007034 (vacuolar transport), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0007041 (lysosomal transport), GO:0033365 (protein localization to organelle), GO:0072666 (establishment of protein localization to vacuole), GO:0006623 (protein targeting to vacuole), GO:0006605 (protein targeting), GO:0072665 (protein localization to vacuole)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Virion infectivity factor (Vif) (SOR protein) [Cleaved into: p17; p7] (Q77YG0)
Organism: Human immunodeficiency virus type 1 (HIV-1)
Function: Not known
Subcellular location: Host cell membrane {ECO:0000256|ARBA:ARBA00004501, ECO:0000256|HAMAP-Rule:MF_04081}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004501, ECO:0000256|HAMAP-Rule:MF_04081}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004501, ECO:0000256|HAMAP-Rule:MF_04081}. Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04081}. Virion {ECO:0000256|ARBA:ARBA00004328, ECO:0000256|HAMAP-Rule:MF_04081}. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion. {ECO:0000256|HAMAP-Rule:MF_04081}.
InterPro domains:
- IPR000475: Retroviral Vif (Viral infectivity) protein (family) [1-192]
Sequence:
MENRWQVMIVWQVDRMRIRTWKSLVKHHMYVSGKARGWFYRHHYESPHPRISSEVHIPLGDARLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPELADQLIHLYYFDCFSDSAIRKALLGHIVSPRCEYQAGHNKVGSLQYLALAALITPKKIKPPLPSVTKLTEDRWNKPQKTKGHRGSHTMNGH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0019079 (viral genome replication), GO:0019058 (viral life cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140535 (intracellular protein-containing complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)