lokahq/bioreason-rl huggingface dataset:
Protein: CD27 molecule (A0A8A1UEA0)
Organism: Rattus norvegicus (Rat)
Function: Not known
InterPro domains:
- IPR053126: CD27 antigen receptor (family) [1-52]
Sequence:
SMLLVFVLGGILFFHQRRNHGPNEDSQAVPEELCPYSCPREEEGSVIPIQED
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0009636 (response to toxic substance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Keratin-associated protein, putative (DUF819) (Similarity to unknown protein) (Q9LTG3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
InterPro domains:
- IPR008537: Protein of unknown function DUF819 (family) [48-461]
Sequence:
MATSLPLLNVIGNSLPSSSRLFRRRSYIVSRQDLPEFSAKSTSSRLSFSPASLSQFRNGTDRFLSPESSSPIRSVTVSSLSTPLISPNDEWGTWTALFATGALGLWSEKTKVGAAMSGALVSTLVGLAASNLGIISSQAPAFAVVLNFLLPLAVPLLLFRADLRRVVQSTGKLLLAFLIGSVATTVGTALAYYLVPMKSLGPDSWKIAAALMGRHIGGAVNYVAISNALGVTPSVLAAGLAADNVICAVYFTTLFALGSKIPAEAVPPPTTIVDAETNEASETKNKIPVLLIATGIAVSLAICKAGALLTKYFGISGGSLPAITAVVVILATVFPSQFGRLAPSGEAMALILMQVFFTVVGASGNIWSVINTAPSIFLFALVQIGTHLAVILGIGKLLNIELRLLLLASNANVGGPTTAAGMATAKGWNSLIVPGILAGIFGIAIATFIGIAFGVKVLKFM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:1901618 (organic hydroxy compound transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0008028 (monocarboxylic acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:1903825 (organic acid transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:1905039 (carboxylic acid transmembrane transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0015718 (monocarboxylic acid transport), GO:0006848 (pyruvate transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009526 (plastid envelope), GO:0042170 (plastid membrane), GO:0009507 (chloroplast), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031969 (chloroplast membrane), GO:0009941 (chloroplast envelope), GO:0009528 (plastid inner membrane), GO:0009706 (chloroplast inner membrane)
Protein: Photosystem II reaction center protein M (PSII-M) (P0C413)
Organism: Oryza sativa subsp. japonica (Rice)
Function: One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. This subunit is found at the monomer-monomer interface.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_00438}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00438}.
InterPro domains:
- IPR007826: Photosystem II PsbM (family) [1-34]
- IPR037269: Photosystem II PsbM superfamily (homologous_superfamily) [1-33]
Sequence:
MEVNILAFIATALFILVPTAFLLIIYVKTVSQND
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0031669 (cellular response to nutrient levels), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: C-phycocyanin alpha subunit (Q54715)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex (phycobilisome, PBS). Phycocyanin is the major phycobiliprotein in the PBS rod.
Subcellular location: Cellular thylakoid membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Part of the phycobilisome rod. {ECO:0000250, ECO:0000269|PubMed:31015331}.
InterPro domains:
- IPR038719: Phycobilisome, alpha/beta subunit superfamily (homologous_superfamily) [1-162]
- IPR006246: Phycocyanin, alpha subunit (family) [2-162]
- IPR009050: Globin-like superfamily (homologous_superfamily) [1-162]
- IPR012128: Phycobilisome, alpha/beta subunit (family) [1-162]
Sequence:
MKTPLTEAVSTADSQGRFLSSTELQIAFGRLRQANAGLQAAKALTDNAQSLVNGAAQAVYNKFPYTTQTQGNNFAADQRGKDKCARDIGYYLRIVTYCLVAGGTGPLDEYLIAGIDEINRTFDLSPSWYVEALKYIKANHGLSGDARDEANSYLDYAINALS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0015669 (gas transport), GO:0015671 (oxygen transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0043229 (intracellular organelle), GO:0034357 (photosynthetic membrane), GO:0043228 (non-membrane-bounded organelle), GO:0042651 (thylakoid membrane), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009579 (thylakoid)
Protein: Ras-related protein Rab-31 (EC 3.6.5.2) (Q921E2)
Organism: Mus musculus (Mouse)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes.
Subcellular location: Early endosome {ECO:0000250|UniProtKB:Q13636}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q13636}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q13636}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000250|UniProtKB:Q13636}.
InterPro domains:
- IPR001806: Small GTPase (family) [1-195]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [4-195]
- IPR005225: Small GTP-binding domain (domain) [6-162]
Sequence:
MMAIRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQERFHSLAPMYYRGSAAAVIVYDITKQDSFHTLKKWVKELKEHGPENIVMAIAGNKCDLSDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLGPQENGNSGGIKLGNQSLQASRRCC
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0046907 (intracellular transport), GO:0051649 (establishment of localization in cell), GO:0006810 (transport), GO:0007034 (vacuolar transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005773 (vacuole), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005770 (late endosome), GO:0005764 (lysosome), GO:0045335 (phagocytic vesicle), GO:0097708 (intracellular vesicle)
Protein: Histone H1.1 (Histone H1a) (Q02539)
Organism: Homo sapiens (Human)
Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:15911621}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:15911621}. Note=Mainly localizes in euchromatin.
InterPro domains:
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [40-112]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [39-112]
- IPR005818: Linker histone H1/H5, domain H15 (domain) [37-120]
- IPR005819: Linker histone H1/H5 (family) [26-214]
Sequence:
MSETVPPAPAASAAPEKPLAGKKAKKPAKAAAASKKKPAGPSVSELIVQAASSSKERGGVSLAALKKALAAAGYDVEKNNSRIKLGIKSLVSKGTLVQTKGTGASGSFKLNKKASSVETKPGASKVATKTKATGASKKLKKATGASKKSVKTPKKAKKPAATRKSSKNPKKPKTVKPKKVAKSPAKAKAVKPKAAKARVTKPKTAKPKKAAPKKK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0031490 (chromatin DNA binding), GO:0019899 (enzyme binding), GO:0003677 (DNA binding), GO:0003723 (RNA binding), GO:0042826 (histone deacetylase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0019953 (sexual reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007283 (spermatogenesis), GO:0048232 (male gamete generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0000792 (heterochromatin), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005694 (chromosome), GO:0005634 (nucleus)
Protein: AT26020p (Q8MZ90)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
InterPro domains:
- IPR011993: PH-like domain superfamily (homologous_superfamily) [129-256]
- IPR000219: Dbl homology domain (domain) [1-119]
- IPR051336: Rho GTPase-activating Guanine Nucleotide Exchange Factors (family) [2-267]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [1-128]
Sequence:
MLQRNRRDLKRLFDEFLQFLDQHCFYGYVIFTMNKQKSLKLCDLYKNYFTSIRLERDDKLGINSFLVQPIQRMARYPLLLTQFINTFFKNRDIVMKPLIESCCRLEKRLRALLTTTNESEIINDIVDCHEFNVYYQGKFRKVNEFQVLDHKLKRSYRSKVFIFDKCIIYTEIKGKNLLFHGRYPCEHIGISAKTKSFTLYYERRKQQECEFTADPVQIAIWLDLIRDMINNYANEERQKLQERYSRENDHLHRKAPSFSLYRDSNRFSSDSGIGNIWIMPKADEDTISNRTTWYAAT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0019899 (enzyme binding), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0051020 (GTPase binding), GO:0030695 (GTPase regulator activity), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009791 (post-embryonic development), GO:0048736 (appendage development), GO:0002165 (instar larval or pupal development), GO:0007552 (metamorphosis), GO:0035107 (appendage morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0009886 (post-embryonic animal morphogenesis), GO:0048513 (animal organ development), GO:0035114 (imaginal disc-derived appendage morphogenesis), GO:0048563 (post-embryonic animal organ morphogenesis), GO:0007560 (imaginal disc morphogenesis), GO:0007444 (imaginal disc development), GO:0048737 (imaginal disc-derived appendage development), GO:0035120 (post-embryonic appendage morphogenesis), GO:0048707 (instar larval or pupal morphogenesis), GO:0048569 (post-embryonic animal organ development), GO:0007478 (leg disc morphogenesis), GO:0007480 (imaginal disc-derived leg morphogenesis), GO:0035218 (leg disc development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Protein patched homolog 3 (H2L0G5)
Organism: Caenorhabditis elegans
Function: Regulates osmosis during embryonic development. Required for larval development and in particular is involved in larval molting.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:21215260}; Multi-pass membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000269|PubMed:21215260}. Note=Co-localizes with ajm-1, an adherens junction marker in hypodermal cells and vulval toroids. {ECO:0000269|PubMed:21215260}.
InterPro domains:
- IPR053958: HMGCR/SNAP/NPC1-like, sterol-sensing domain (domain) [656-804]
- IPR000731: Sterol-sensing domain (domain) [627-788]
Sequence:
MSFPDEETDLLSEAKHCIRNVIHRTHRKFLENRLIGNFDSEDFSDAWKKKFAHAPTWCDADMSLQQIKRGKAVGNTVALTARAFFQLWLFRIGCFVQRWAWSTIFISLFLYCLCLGGLRHVTIETDLVKLWVSEGGRLNEEMGYLGQVKFERESGHLVHKVKRAVEQTTEPPAPAVKAEVRRGPELPKENGLGGGFQVVIQTPSFDGQNILSKEALQQHTKLMEEISTYEVKMFNETWTLSDICFKPPGPSFNSGPLAGIMSKLLDKIIPCIWITPIDCYWDGAKPLGPNPPLNLGPEVASFVSSLPPGNVTWKNLNPTSVIKEVGTLFDLGPIGNFFERAGIDGAYLDRPCIDPLEEECPKSAPNYFDRCHALTKFNEWNMAKAMSEQVTLERKIIPKDDGKSDIAETILNDIFGKKRRKRQADTTTKKPATKKDEDYYEYEDDADYLAGIANSTIAKKNPEKEAKDLLCLEYGSSLLKWMQENPERLGEFLTKEEMPDYPNYGDVMTGGCKGFGKKIMEWPEDLIIGGIQRDNGKLVSAEALQSVFLVSGAYDVFARIKNDKTDSHPGLDRHHFQPWMAGEIISTWQRNFTKRLYSHELNRERRQFHPLASTSIADMLEEFSQFNYIIIVIGYILMVIYAAFTQGRFQGWWLAVQSNVALAICGVILVTISSICGLGFATHLGINFNAATTQVVPFLSLGLGIDDMFLLLHNYDEIINICNKNEIGVLLKETGMSVMLTSINNILAFISGYVLPIPALRSFCSQTAILLAFNLIFLMFIFPAMIGIDLRRQRKGKRDLAYCSRGNPQMATSQSVPSNVSNMSSRAELAGYEKQADEYKRHEPWYTVGGFLNKIYIPALKNNVVKACVLIGTTTAVVFGLYGMYTSTLGLELADVLPEHTPPAAFLRAREQYFSFYPMFAVLRGDKLDIPNQQQLIEEYRAQLGSSKFMIKAEGKLQPYWMSMLRVWLQSLDMALEKDLAAGKFDLTNGNPIKVNGEKPSPESMIAARLVCSFGTNYNCDGRLGKMKMVENEVINPEGFYNYLTGWFNVDNMMYYVSQASFYPTPPGWEYNEKLAKVVPAAEPLLYSQMPFYQNDLIDTPAIVKMIEEIRATCEEYSERGLSNHPSGIAFTFWEQYLTLRWNLFQAICIIALAVFCVISILMFNPWAATLIMCIVVITTIELGGFMGLMGIKMNPISAVTLICAVGIGVEFTAHVELAFLTALGTIDQRLESCLQHMFVPVYHGAISTFLGVVMLVFSEFDFVVTYFFYTMTLLVALGVFNGLCVLPVILTLVGPKPELTPTDGSSVLPPPPPLRQQYAEKSGGVEGGMRKRKEKRPAEVEMSARDSPSTSSASHSSDDESSPAHK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0042303 (molting cycle), GO:0018996 (molting cycle, collagen and cuticulin-based cuticle)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0042303 (molting cycle), GO:0018996 (molting cycle, collagen and cuticulin-based cuticle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: AlkB homolog 3, alpha-ketoglutarate dependent dioxygenase (E9PSA5)
Organism: Homo sapiens (Human)
Function: Not known
InterPro domains:
- IPR037151: Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily (homologous_superfamily) [69-223]
- IPR027450: Alpha-ketoglutarate-dependent dioxygenase AlkB-like (domain) [89-219]
- IPR032854: Alkylated DNA repair protein alkB homologue 3 (family) [21-222]
Sequence:
MEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQQVVRRAPEPRVIEEGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTGIREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0032451 (demethylase activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006304 (DNA modification), GO:0006281 (DNA repair), GO:0006307 (DNA dealkylation involved in DNA repair), GO:0035510 (DNA dealkylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Tubulin polymerization-promoting protein family member 3 (TPPP/p20) (Q9BW30)
Organism: Homo sapiens (Human)
Function: Regulator of microtubule dynamic that has microtubule bundling activity. Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation of beta-catenin.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:30667362}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:17105200}.
InterPro domains:
- IPR011992: EF-hand domain pair (homologous_superfamily) [2-138]
- IPR008907: Tubulin polymerization-promoting protein (family) [6-175]
Sequence:
MAASTDMAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKVADGKSVTGTDVDIVFSKVKGKSARVINYEEFKKALEELATKRFKGKSKEEAFDAICQLVAGKEPANVGVTKAKTGGAVDRLTDTSRYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:2000241 (regulation of reproductive process), GO:0040012 (regulation of locomotion), GO:0050794 (regulation of cellular process), GO:1901317 (regulation of flagellated sperm motility), GO:2000145 (regulation of cell motility), GO:0032886 (regulation of microtubule-based process), GO:1902019 (regulation of cilium-dependent cell motility), GO:0060632 (regulation of microtubule-based movement), GO:0060295 (regulation of cilium movement involved in cell motility), GO:0003352 (regulation of cilium movement)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)