Protein: Protein MICRORCHIDIA 1 (AtMORC1) (EC 3.6.-.-) (Protein COMPROMISED RECOGNITION OF TCV 1) (Q84WV6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediator of defense signaling triggered by distinct classes of R proteins. Required during hypersensitive response (HR) that confers disease resistance to turnip crinkle virus (TCV). Exhibits ATPase activity. Contributes to resistance against Pseudomonas syringae and Hyaloperonospora arabidopsidis, at early stages prior to cytosolic calcium ions Ca(2+) accumulation. Required for pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI), basal resistance, non-host resistance and systemic acquired resistance (SAR). Binds DNA/RNA in a non-specific manner and exhibits endonuclease activity. Probably involved in DNA repair. Required for both RPP8- and SSI4-mediated resistance responses, thus being involved in both TIR- and CC-NB-LRR pathways. Involved in RNA-directed DNA methylation (RdDM) as a component of the RdDM machinery and required for gene silencing. May also be involved in the regulation of chromatin architecture to maintain gene silencing.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:22555433, ECO:0000269|PubMed:23250427}. Endosome {ECO:0000269|PubMed:20332379}. Note=Present in nuclear bodies near chromocenters (PubMed:22555433). Localized in endosome-like vesicles displaying rapid cytosolic streaming (PubMed:20332379). Accumulates in the nucleus following pathogen-associated molecular pattern (PAMP) treatment or infection with an avirulent pathogen (PubMed:23250427). {ECO:0000269|PubMed:20332379, ECO:0000269|PubMed:22555433, ECO:0000269|PubMed:23250427}.
InterPro domains:
- IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [85-292]
- IPR041006: Morc, S5 domain 2-like (domain) [332-470]
- IPR045261: MICRORCHIDIA ATPase family (family) [41-634]
Sequence:
MAKNYTVADVVNIDSDSDSDDDNGGVIGMVPSLASLIENQKVSIADAATVAPRETLECRSFWKAGENFVIPSSVTLTAIGMVEHARVHPKFLHSNATSHKWAFGAIAELLDNAVDEIQNGATVVKIDKINIVKDNTPALVFQDNGGGMDPNGIRKCMSLGYSSKKSNTTIGQYGNGFKTSTMRLGADAMVFSRSTRGGKSTQSIGLLSYTFLRKTGQDDVIVPMIDFDISSDSPQPIIYGSPGDWSTNLNILLKWSPFSTMVELLQQFEDIGTHGTKVIIYNLWLNDEGIYELSFDDDDVDIRLRDENAQDGKRLHAKTLEVRSHISYRYRHSLRAYISMLYLKKFKNFKIILRGVSVAQFNIADEFRHPETIMYKPQAAAVDYAATGIKVGFIKEAPKLPICGFNVYHKNRLIRPFWKVVLEGSTRGNGVMGVLEANFIEPAHDKQDFERSSLFLRLEARLKRITSDYWQNHCHIFGYQTAQIPADKSKRTVIPDQPPTVNTYNPSPLPSDRISHGGPIIREINLSNATSSRTAAVAAPHLRNYTGLRNNFQPVQLNPQPPAAGDTGNNLVGKLAAEIREENLQLFMRCEEYVKKENEVEQTVKSLEKELEEIKSKCAQLALLVDAKKKEMQQV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048584 (positive regulation of response to stimulus), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0008219 (cell death), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0012501 (programmed cell death), GO:0043207 (response to external biotic stimulus), GO:0051702 (biological process involved in interaction with symbiont), GO:0033554 (cellular response to stress), GO:0002833 (positive regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0006952 (defense response), GO:0032101 (regulation of response to external stimulus), GO:0031349 (positive regulation of defense response), GO:0009615 (response to virus), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0031347 (regulation of defense response), GO:0009626 (plant-type hypersensitive response), GO:0140546 (defense response to symbiont), GO:1900426 (positive regulation of defense response to bacterium), GO:0051607 (defense response to virus), GO:0010112 (regulation of systemic acquired resistance), GO:1900424 (regulation of defense response to bacterium), GO:0034050 (programmed cell death induced by symbiont)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0010369 (chromocenter), GO:0005634 (nucleus)