lokahq/bioreason-rl huggingface dataset:
Protein: Calcium uniporter protein, mitochondrial (DdMCU) (Q54LT0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:24889638}; Multi-pass membrane protein {ECO:0000255}.
InterPro domains:
- IPR039055: MCU family (family) [28-267]
- IPR006769: Calcium uniporter protein, C-terminal (domain) [74-251]
Sequence:
MNSFVIRNGFGLVRTFNTRLFTTSTQNLEGELKTILGQAKVSKLQEKLKLDPRSKITFNDFKGIAKEVGIEEKEINSVSNALAQSGSIIYLPNSLNENLKTSVFTKPAHIYQSLEHILDIENKGVGLNKLIESKKSEINSLRQKIQPLEEKKQVIDRKAHRRATAIIWTGLGYCFAQAAILARLTWWDLSWDIIEPVSYFLTFGSVLIGYTYFTMTKTEFTYEALNHRLFSKRQDKLFKRNNFPKEDYENLVQAIDKKEKELKELELATKYDHTH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:1990542 (mitochondrial transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0006851 (mitochondrial calcium ion transmembrane transport), GO:0071702 (organic substance transport), GO:0098662 (inorganic cation transmembrane transport), GO:0006811 (monoatomic ion transport), GO:0070588 (calcium ion transmembrane transport), GO:0006816 (calcium ion transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0051560 (mitochondrial calcium ion homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043229 (intracellular organelle), GO:0098800 (inner mitochondrial membrane protein complex), GO:0005739 (mitochondrion), GO:1902495 (transmembrane transporter complex), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0034702 (ion channel complex), GO:0019866 (organelle inner membrane), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane), GO:0034703 (cation channel complex), GO:0034704 (calcium channel complex)
Protein: Paired box 10 (V5ZE41)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
InterPro domains:
- IPR001356: Homeodomain (domain) [72-136]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [62-133]
- IPR017970: Homeobox, conserved site (conserved_site) [107-130]
- IPR050649: Paired Homeobox Transcription Factors (family) [62-229]
Sequence:
MYDNLTMLNLQNSSNWSGPNNWYHPADTITPQHGTDGCVEDLNVQMAGAGEGVVQGERDEVDDSQLHLQLKRKLQRNRTSFTQEQIDALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRSGSSSSCSQTHTPLSTSFNSPVYHSHHSNSSGSMHSRSDSSLSGYSSLSVFSSMQSLPSQSTPTYSCMLPPSPSALPPLSRKFDSSSYTSPHLPPPPTASANTGFFAGVSAAGQTAVQGGDQELGQGLSQYWTRLQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060041 (retina development in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Candida glabrata strain CBS138 chromosome C complete sequence (Q6FWP8)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
InterPro domains:
- IPR022751: Alpha-mannosyltransferase (family) [238-513]
- IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [236-473]
Sequence:
MSLLARYLLQRRVKRYSVLFVLFVGLFIFIARHLTNEEESDNGIYKDDKFPYEDGLLHSSSNSAYTFITDAMNKLTKKKKNSFLSPKGLSYFKDDERILKNWNTSSRVDKCKWLIRGIYADPNWNNRDILIGSDETNDKNKFHLSSERIRIHNYCFMKERIDPVQMFNELNISSTDAYDFQGRMFMFLRNVTSTDEAYIYPIIKNVRNGQVTTKPHTKLSPMQYNSNFMAYWKQESKGRGIALTAAPKDVKLLRSLFKVFEKLGNTYPIQIVQKGGEMSPTMESLIKDYAIETNQNVFIVDLSPVLDPDFATDHIRKFQNKWFASIFNTFEEVMLIDADVVIYTEPESFFNLDGYKNTGLLLWRDREIVDAKTHERCTDMAPYFEPALEEHRLLGTVQKYRLTGPSLETHDEPEAETLFDFFHRRIVTIIDSGVVIYNKKQKLHGLILAEYFHNSKQFAGCVYGDKEYFEFGALVAGEDYHVEAEKAVAIGAVGYHPPREKYYVCSGQMGHVDRNNNLLWSNGGLKNCKSDCAEADFEKMPKYFKAKYGTLKAVKEYYNGLMDIQGFVLPDVQKQKWVQYPDCQQFLYCAFITDPPEPDNKGKLVRFSDEEKMRYNEIGKAWYSGAND
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0000030 (mannosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0070085 (glycosylation), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043413 (macromolecule glycosylation), GO:1901135 (carbohydrate derivative metabolic process), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0006486 (protein glycosylation), GO:0043412 (macromolecule modification), GO:0009100 (glycoprotein metabolic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0009101 (glycoprotein biosynthetic process), GO:0006493 (protein O-linked glycosylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: Glutamate--cysteine ligase (EC 6.3.2.2) (Gamma-ECS) (GCS) (Gamma-glutamylcysteine synthetase) (Q9W3K5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis.
InterPro domains:
- IPR014746: Glutamine synthetase/guanido kinase, catalytic domain (homologous_superfamily) [39-505]
- IPR004308: Glutamate-cysteine ligase catalytic subunit (family) [1-695]
Sequence:
MGLLSEGSPLSWEETKALADHVREHGVNQFINLYHRLKDRQGDILKWGDEVEYIIVKFDDEQKVARVALRAQDLLAQLNEKELADPNGVKSLWRPEYGAYMIEGTPGKPFGGLMAHFNLVEANMRYRREEVTELLAKDECVMSITNFPRLGAPNFTYPLAQPRPEDPLSSARSLYFPDEAIFPGHPRFKTLTRNIRKRRGEKVSIKLKVFKDTKTKLPVEGAPPGEPDVVLLDAMGFGMGCCCLQLTFQACNITEARRLYDQLAPLCPIMLALTAASPIYRGYLTESDCRWNVISSSVDCRTEEERGLAPLDQQKFRIAKSRYDSIDSYLSPEGAKYNDVPLTYDEKVYQRLVEGGIDHLLAQHVAHLFIRDTVSLFSEKVHQNDNEDTDHFENIQSTNWQTMRFKPPPPNSSIGWRVEFRPCEAQISDFENAAIVCFVVLLTRVILSYQLNFLTPISKVDENMQTAQKRDACRKEKFWFRKSSKTTEQRAAKAQAQAQAQAKAQAQTNGKATLNGNGLANGNGNGSENSDQEEQQPLTNGSAKMNGHGSGTTNGTNGSSNGSSNGTDSDHTDTDDEENELFQLLSINEIFNGKPNVFPGLVPLIRSYLQSMEVDTDTHCTIEQYLRFIQKRAAGELITTATWMREQVLSHPDYKQDSVVSERINYDLLKRIQGIQEGKQVEPALLGQDYHSKTKTKDFIPPALQKQLAKNGCCEEK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0016879 (ligase activity, forming carbon-nitrogen bonds), GO:0016881 (acid-amino acid ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0001101 (response to acid chemical), GO:0006749 (glutathione metabolic process), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006979 (response to oxidative stress), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006750 (glutathione biosynthetic process), GO:0006518 (peptide metabolic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0043043 (peptide biosynthetic process), GO:0019184 (nonribosomal peptide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)
Protein: Inactive leucine-rich repeat receptor-like serine/threonine-protein kinase At5g24100 (Q9FL63)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
InterPro domains:
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [344-610]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [32-231]
- IPR013210: Leucine-rich repeat-containing N-terminal, plant-type (domain) [31-68]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [344-608]
- IPR001611: Leucine-rich repeat (repeat) [73-213]
- IPR017441: Protein kinase, ATP binding site (binding_site) [347-369]
- IPR000719: Protein kinase domain (domain) [341-611]
- IPR050994: Arabidopsis Inactive Receptor-like Kinases (family) [9-611]
Sequence:
MSRGRSFIFYFVLFLFFGSSALYSQVTGDLAGDRQALLDFLNNIIHPRSLAWNTSSPVCTTWPGVTCDIDGTRVTALHLPGASLLGVIPPGTISRLSELQILSLRSNGLRGPFPIDFLQLKKLKAISLGNNRFSGPLPSDYATWTNLTVLDLYSNRFNGSIPAGFANLTGLVSLNLAKNSFSGEIPDLNLPGLRRLNFSNNNLTGSIPNSLKRFGNSAFSGNNLVFENAPPPAVVSFKEQKKNGIYISEPAILGIAISVCFVIFFVIAVVIIVCYVKRQRKSETEPKPDKLKLAKKMPSEKEVSKLGKEKNIEDMEDKSEINKVMFFEGSNLAFNLEDLLIASAEFLGKGVFGMTYKAVLEDSKVIAVKRLKDIVVSRKDFKHQMEIVGNIKHENVAPLRAYVCSKEEKLMVYDYDSNGSLSLRLHGKNADEGHVPLNWETRLRFMIGVAKGLGHIHTQNLAHGNIKSSNVFMNSEGYGCISEAGLPLLTNPVVRADSSARSVLRYRAPEVTDTRRSTPESDIYSFGILMLETLTGRSIMDDRKEGIDLVVWVNDVISKQWTGEVFDLELVKTPNVEAKLLQMLQLGTSCTAMVPAKRPDMVKVVETLEEIERD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0040007 (growth), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0009653 (anatomical structure morphogenesis), GO:0016049 (cell growth), GO:0071554 (cell wall organization or biogenesis), GO:0000902 (cell morphogenesis), GO:0016043 (cellular component organization), GO:0071669 (plant-type cell wall organization or biogenesis), GO:0071555 (cell wall organization), GO:0060560 (developmental growth involved in morphogenesis), GO:0009826 (unidimensional cell growth), GO:0045229 (external encapsulating structure organization), GO:0009664 (plant-type cell wall organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Variant-surface-glycoprotein phospholipase C (VSG lipase) (EC 4.6.1.14) (Glycosylphosphatidylinositol-specific phospholipase C) (GPI-PLC) (P09194)
Organism: Trypanosoma brucei brucei
Function: By hydrolysis of the attached glycolipid, releases soluble variant surface glycoprotein containing phosphoinositol from the cell wall of T.brucei after cell lysis. It also cleaves similar membrane anchors on some mammalian proteins. VSG lipase may play a role in processes such as parasite differentiation or antigenic variation.
Subcellular location: Membrane; Peripheral membrane protein.
InterPro domains:
- IPR000909: Phosphatidylinositol-specific phospholipase C, X domain (domain) [19-198]
- IPR017946: PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily (homologous_superfamily) [8-351]
- IPR051057: Phosphoinositide phospholipase C domain-containing protein (family) [11-343]
Sequence:
MFGGVKWSPQSWMSDTRSSIEKKCIGQVYMVGAHNAGTHGIQMFSPFGLDAPEKLRSLPPYVTFLLRFLTVGVSSRWGRCQNLSIRQLLDHGVRYLDLRMNISPDQENKIYTTHFHISVPLQEVLKDVKDFLTTPASANEFVILDFLHFYGFNESHTMKRFVEELQALEEFYIPTTVSLTTPLCNLWQSTRRIFLVVRPYVEYPYARLRSVALKSIWVNQMELNDLLDRLEELMTRDLEDVSIGGVPSKMYVTQAIGTPRNNDFAVAACCGACPGSHPDLYSAAKHKNPHLLKWFYDLNVNGVMRGERVTIRRGNNTHGNILLLDFVQEGTCTVKGVDKPMNAVALCVHLNTNQTARS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity), GO:0004620 (phospholipase activity), GO:0004629 (phospholipase C activity), GO:0004435 (phosphatidylinositol phospholipase C activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0046486 (glycerolipid metabolic process), GO:0006644 (phospholipid metabolic process), GO:0006650 (glycerophospholipid metabolic process), GO:0046488 (phosphatidylinositol metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0097014 (ciliary plasm)
Protein: Translation initiation factor eIF3 subunit (Q4Q9M6)
Organism: Leishmania major
Function: Not known
InterPro domains:
- IPR013906: Eukaryotic translation initiation factor 3 subunit J (family) [10-196]
Sequence:
MDDYHDDDVHSNYGYEDDEYDDAADDWEAEAAEEEQRAVAEEAARQARLEKKLATRAPVKKEEEEEAVPEDVERAMADMRQVANDIASGSALLSGGDSEELIGNHKLASDADVERVGTMIADRLTSFSDSGHYDKLIVEVFQRLTNHLTSTHLLNEEADRVHRLREELKRAAKAKLKPVEKAPVTQSGLDLDNFEDRGGAAVADNEDETGW
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0010467 (gene expression), GO:0042254 (ribosome biogenesis), GO:0042274 (ribosomal small subunit biogenesis), GO:0016070 (RNA metabolic process), GO:0043043 (peptide biosynthetic process), GO:0002181 (cytoplasmic translation), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0030490 (maturation of SSU-rRNA), GO:0006364 (rRNA processing), GO:0034660 (ncRNA metabolic process), GO:0016072 (rRNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005852 (eukaryotic translation initiation factor 3 complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)
Protein: Copper transport protein ctr6 (Copper transporter 6) (Q9USV7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mobilizes stored copper from the vacuole to the cytoplasm under conditions of copper limitation.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:12244050}; Multi-pass membrane protein {ECO:0000269|PubMed:12244050}.
InterPro domains:
- IPR007274: Ctr copper transporter (family) [5-133]
Sequence:
MNHGGNSTMRHCSMKMTFNTDYDNLCIVFKSWHIGNLSQFLLSLLAIAILGYLFERLRSFTSLKETEFQRGYAGQQSEGLLTHHSKSLKSGRPFRLCALYAVQLVFSYFLMLVAMTYNAYVILAIAIGAAFGYRRSHCDTVQTVGLCH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0005375 (copper ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006825 (copper ion transport), GO:0015677 (copper ion import)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle), GO:0000322 (storage vacuole), GO:0000324 (fungal-type vacuole), GO:0098852 (lytic vacuole membrane), GO:0000329 (fungal-type vacuole membrane)