lokahq/bioreason-rl huggingface dataset:
Protein: EG:131F2.2 protein (O76875)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
InterPro domains:
- IPR012337: Ribonuclease H-like superfamily (homologous_superfamily) [349-502]
- IPR013520: Ribonuclease H-like domain (domain) [347-508]
- IPR047021: RNA exonuclease REXO1/REXO3/REXO4-like (family) [22-507]
- IPR034922: RNA exonuclease 1-like, exonuclease domain (domain) [349-500]
- IPR036397: Ribonuclease H superfamily (homologous_superfamily) [345-510]
Sequence:
MAKGPEQLHPQQQMQQQKRGRNKKPGKWSNNIIDNPNSNHGGSSQQKTCDSSSSSALSSPTSSATTSATSSPTNSPTSYPRANGNRKRIEAALEWRREQELGRQNANFLVPPLRQYEQLEFDDKTVVQQLRRHIIDNHLLRVYGFPVDSVVHEGAIEIFKCMPHMSFAAALAETAQAVTVINYHDGLTNRAEEEVANSTDSGNSSPQSLDSESGGEWSGSECESSNSSSSSAGEAALGLELKYCHFVPVERSLSKPCARCKRHFLVDELTGQYLTHEECQYHSGKYQRYYDGVSHGRWTCCNEGEESSPGCCLGDRHVWSGSVVGVNGPYYDFVRTEHRGSGEDEPAVYALDCEMSYTGRGLDVTKVSLVALNGQLVYEHFVRPVCDIIDYNTQYSGITETDLCSGAKSLAEVQRDLLQLITADTILIGHGLENDLRALRLVHNTLIDTSISFPHCNGFPYRRALRHLTKVHLKRDIQAGDGTTGHSSFEDSRACMELMLWRVNRELDPAWSWDD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0004540 (ribonuclease activity), GO:0004532 (exoribonuclease activity), GO:0004527 (exonuclease activity), GO:0008408 (3'-5' exonuclease activity), GO:0016896 (RNA exonuclease activity, producing 5'-phosphomonoesters), GO:0016796 (exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters), GO:0000175 (3'-5'-RNA exonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0007343 (egg activation), GO:0019953 (sexual reproduction), GO:0001775 (cell activation), GO:0009566 (fertilization), GO:0007338 (single fertilization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Tim10-like domain-containing protein (Q57Z59)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
InterPro domains:
- IPR035427: Tim10-like domain superfamily (homologous_superfamily) [2-86]
- IPR004217: Tim10-like (domain) [6-74]
Sequence:
MQSQMMLMQAMERYGMLDLANSALEQCWDICYDRNLTRHELVEGVLPDAKLQKMEACQRKCIARHFEVMRLMNASREQREKEMLQGLPPGSLGME
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0051668 (localization within membrane), GO:0045184 (establishment of protein localization), GO:0006839 (mitochondrial transport), GO:0090151 (establishment of protein localization to mitochondrial membrane), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0071702 (organic substance transport), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0090150 (establishment of protein localization to membrane), GO:0061024 (membrane organization), GO:0072657 (protein localization to membrane), GO:0072655 (establishment of protein localization to mitochondrion), GO:0007005 (mitochondrion organization), GO:0033365 (protein localization to organelle), GO:0007006 (mitochondrial membrane organization), GO:0006605 (protein targeting), GO:0051205 (protein insertion into membrane), GO:0051204 (protein insertion into mitochondrial membrane), GO:0006626 (protein targeting to mitochondrion), GO:0070585 (protein localization to mitochondrion), GO:0007007 (inner mitochondrial membrane organization), GO:0045039 (protein insertion into mitochondrial inner membrane)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0098796 (membrane protein complex), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0098800 (inner mitochondrial membrane protein complex), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)
Protein: Metallothionein-1X (MT-1X) (Metallothionein-IX) (MT-IX) (P80297)
Organism: Homo sapiens (Human)
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling.
InterPro domains:
- IPR018064: Metallothionein, vertebrate, metal binding site (binding_site) [13-31]
- IPR000006: Metallothionein, vertebrate (family) [1-61]
- IPR017854: Metallothionein domain superfamily (homologous_superfamily) [1-61]
- IPR023587: Metallothionein domain superfamily, vertebrate (homologous_superfamily) [1-61]
Sequence:
MDPNCSCSPVGSCACAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGTSDKCSCCA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0042592 (homeostatic process), GO:0051716 (cellular response to stimulus), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0042221 (response to chemical), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0010035 (response to inorganic substance), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0010038 (response to metal ion), GO:0034097 (response to cytokine), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0071241 (cellular response to inorganic substance), GO:0071310 (cellular response to organic substance), GO:0055070 (copper ion homeostasis), GO:0006878 (intracellular copper ion homeostasis), GO:0071248 (cellular response to metal ion), GO:0010043 (response to zinc ion), GO:0071345 (cellular response to cytokine stimulus), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0071294 (cellular response to zinc ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Peroxisomal membrane protein PEX3 (PMP PEX3) (Peroxin-3) (Peroxisomal membrane protein PAS2) (C4R6F0)
Organism: Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Function: Not known
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:10359594, ECO:0000269|PubMed:21576455, ECO:0000269|PubMed:8702562}; Single-pass membrane protein {ECO:0000255}. Note=Traffics to peroxisomes via the endolasmic reticulum (ER), where it accumulates in the absence of PEX19. {ECO:0000269|PubMed:21576455}.
InterPro domains:
- IPR006966: Peroxin-3 (family) [3-452]
Sequence:
MLEYTAGLIRRNKKKFLISSGIIGVGYYVTKTINNKIQEFQNRIREENFAKEQIKRRFHQTQSDCYMTFLSLLPVLCEPIMDDLPVETITKQLQIRRLEKQIGNKDVKNSGSTVLSDDFSTSQEGAISEDTNKPPELKSKNQLWQELKIKAITRFLTLIYCESLLIVFLHLQLNILSRKSYLETAIRLASETQGIDLVDQESNGDFSGNTQDENLSEQAFLSFSWWLLNKGWLEIKNKIEPCVEQHFGGINPRQQLKINEFAELLNKCQNCIDLKVLNLTEDDIHLGVGVIEDQSQPVGRKSTNFITNALLPPKEFEFFLLQQTNDLDFLSRFNNNIVNTESLNMLLDELNNYLNNADINLIVNKLATLGITKVLDEIVLNLLQKNRPNPISDMNIRDIDLNDFPPYKLAALLANITKQSISLTNNSVENPILADLNNLPELNDLSASVYSNFDP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:0090304 (nucleic acid metabolic process), GO:0000723 (telomere maintenance), GO:0051276 (chromosome organization), GO:0032200 (telomere organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0042579 (microbody), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome), GO:0098588 (bounding membrane of organelle), GO:0031903 (microbody membrane), GO:0005778 (peroxisomal membrane)
Protein: Putative pentatricopeptide repeat-containing protein At1g64310 (Q9C7V5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
InterPro domains:
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [4-547]
- IPR046960: Pentatricopeptide repeat-containing protein At4g14850-like, plant (family) [228-551]
- IPR002885: Pentatricopeptide repeat (repeat) [70-443]
- IPR046848: E motif (repeat) [490-551]
Sequence:
MASQTQLRLIIYEFTRKIQTRLNTQKLHSFVTKSKLARDPYFATQLARFYALNDDLISARKLFDVFPERSVFLWNSIIRAYAKAHQFTTVLSLFSQILRSDTRPDNFTYACLARGFSESFDTKGLRCIHGIAIVSGLGFDQICGSAIVKAYSKAGLIVEASKLFCSIPDPDLALWNVMILGYGCCGFWDKGINLFNLMQHRGHQPNCYTMVALTSGLIDPSLLLVAWSVHAFCLKINLDSHSYVGCALVNMYSRCMCIASACSVFNSISEPDLVACSSLITGYSRCGNHKEALHLFAELRMSGKKPDCVLVAIVLGSCAELSDSVSGKEVHSYVIRLGLELDIKVCSALIDMYSKCGLLKCAMSLFAGIPEKNIVSFNSLILGLGLHGFASTAFEKFTEILEMGLIPDEITFSALLCTCCHSGLLNKGQEIFERMKSEFGIEPQTEHYVYMVKLMGMAGKLEEAFEFVMSLQKPIDSGILGALLSCCEVHENTHLAEVVAENIHKNGEERRSVYKVMLSNVYARYGRWDEVERLRDGISESYGGKLPGISWF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0016070 (RNA metabolic process), GO:0009451 (RNA modification), GO:1900864 (mitochondrial RNA modification), GO:0016071 (mRNA metabolic process), GO:0000959 (mitochondrial RNA metabolic process), GO:0016556 (mRNA modification), GO:0080156 (mitochondrial mRNA modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Uncharacterized protein, isoform C (M9NED4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
InterPro domains:
- IPR001810: F-box domain (domain) [544-577]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [659-848]
- IPR052283: Genomic Stability and Neuronal Morphogenesis Regulator (family) [189-937]
- IPR036047: F-box-like domain superfamily (homologous_superfamily) [543-590]
Sequence:
MDVPDDNFGPSKPCDKQPLAGNSSSATNSSSHTGGNGNVDSAFESSTAAGPSSGANQSSTGGAIDEQGSIGEQSAGVGQNIIEGDLLVLNANSTNVDLSTHRDGSSFKDSNTEQGKKSTMIKTSKTLNDKSQFERRRRRGRQRERHREPSTHRDDLEPCDLGLMGWTGEFPKLTPISNIESNSDKEPLVEDKKEDTTKKQAEADHTLHKSLKDARIVKRSMSTHSPPEHSRRSVRFSSHTPLTDETNIMKETSTETSLKVIFERLKQTGVERDLFIPSSENPRPRSNGSPVPKVAEMEHVAVVKCKTVAKQGAVVKGKAGLANPSNVMPQTPALTVTGKRVSKPKVPKGASPPSEGWTSTRAVKGNSRADYTNSSSCGSPIGNTNIRRRRAHAKAAPDKSKPCVRCAASVHPSGPKLCKKCIYEKGYANKKWMKKTGGNEDHYDDDDDSDFSMIEVTLENEISVQQAEKKQLENVNKQTVIKEQEVVVIGGRKAIAIIADPIGCNLKVIPNRQNLAGLKKISKDKCSSSLVQSLGDCHIGCQIVMAVMKIMTMKDRVNMAQVCKTWAMISQDKSVWRTVMLRDTHISNWPRFIRELANNCTRELDMLGVILPNPPDILATLDISVLKALRVLRTCPVDDQFLFKVFRELPQLLELRAICYSPTFNFLNLARQWSKIRVLQILMTDHRSKVESLDSLGDLVHLTELNIRGVNYIGSQDFRFLKKLVNLKVLVLSSCQGMDTEEFGQQVLPFLTSLRRLRLENKHMINTTFPLYHIMCGVAAACSVQQLELVNVEVDDLLTSLIGMCTTVTHLLLVPKCLQNSANVIYSVMRAVRENASQLRVFRLGLVTQLLSATGELYRGSKKDVIPVERPVPGIPLDDDLNYCAPDDRCIETDHTECVTFLPAKRLLMILRDVAPTTFVTFVKVNMFNSTMVTFLKRPQLKNK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Receptor associated protein of the synapse (E9PJP9)
Organism: Homo sapiens (Human)
Function: Not known
InterPro domains:
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [2-305]
- IPR001237: 43kDa postsynaptic protein (family) [3-42]
- IPR018293: 43kDa postsynaptic, conserved site (conserved_site) [2-10]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [306-351]
- IPR052480: Receptor-associated synaptic protein (family) [1-178]
- IPR019734: Tetratricopeptide repeat (repeat) [6-266]
- IPR019568: Rapsyn, myristoylation/linker region, N-terminal (domain) [1-80]
- IPR001841: Zinc finger, RING-type (domain) [310-350]
Sequence:
MGQDQTKQQIEKGLQLYQSNQTEKALQVWTKVLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVARKALDKALDAIERAQDLAEEVGNKLSQLKLHCLSESIYRSKGLQRELRAHVVRFHECVEETELYCGLCGESIGEKNSRLQALPCSHIFHLRCLQNNGTRSCPNCRRSSMKPGFV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0007267 (cell-cell signaling), GO:0007154 (cell communication), GO:0099536 (synaptic signaling), GO:0099537 (trans-synaptic signaling), GO:0098916 (anterograde trans-synaptic signaling), GO:0007268 (chemical synaptic transmission), GO:0007271 (synaptic transmission, cholinergic)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Chaperonin GroEL 1 (EC 5.6.1.7) (60 kDa chaperonin 1) (Chaperonin-60 1) (Cpn60 1) (P9WPE9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Prevents aggregation of substrate proteins and promotes their refolding. In vitro, activity may be independent of the presence or absence of the GroES co-chaperonin or ATP. Shows weak ATPase activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00600}.
InterPro domains:
- IPR027410: TCP-1-like chaperonin intermediate domain superfamily (homologous_superfamily) [136-408]
- IPR018370: Chaperonin Cpn60, conserved site (conserved_site) [403-414]
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [183-374]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [22-525]
- IPR027413: GroEL-like equatorial domain superfamily (homologous_superfamily) [5-522]
- IPR001844: Chaperonin Cpn60/GroEL (family) [1-537]
Sequence:
MSKLIEYDETARRAMEVGMDKLADTVRVTLGPRGRHVVLAKAFGGPTVTNDGVTVAREIELEDPFEDLGAQLVKSVATKTNDVAGDGTTTATILAQALIKGGLRLVAAGVNPIALGVGIGKAADAVSEALLASATPVSGKTGIAQVATVSSRDEQIGDLVGEAMSKVGHDGVVSVEESSTLGTELEFTEGIGFDKGFLSAYFVTDFDNQQAVLEDALILLHQDKISSLPDLLPLLEKVAGTGKPLLIVAEDVEGEALATLVVNAIRKTLKAVAVKGPYFGDRRKAFLEDLAVVTGGQVVNPDAGMVLREVGLEVLGSARRVVVSKDDTVIVDGGGTAEAVANRAKHLRAEIDKSDSDWDREKLGERLAKLAGGVAVIKVGAATETALKERKESVEDAVAAAKAAVEEGIVPGGGASLIHQARKALTELRASLTGDEVLGVDVFSEALAAPLFWIAANAGLDGSVVVNKVSELPAGHGLNVNTLSYGDLAADGVIDPVKVTRSAVLNASSVARMVLTTETVVVDKPAKAEDHDHHHGHAH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009628 (response to abiotic stimulus), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0044403 (biological process involved in symbiotic interaction), GO:0006457 (protein folding), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0051701 (biological process involved in interaction with host), GO:0001666 (response to hypoxia), GO:0044093 (positive regulation of molecular function), GO:0051098 (regulation of binding), GO:0042026 (protein refolding), GO:0070482 (response to oxygen levels), GO:0051099 (positive regulation of binding), GO:0051101 (regulation of DNA binding), GO:0044406 (adhesion of symbiont to host), GO:0036293 (response to decreased oxygen levels), GO:2000677 (regulation of transcription regulatory region DNA binding), GO:0043388 (positive regulation of DNA binding), GO:2000679 (positive regulation of transcription regulatory region DNA binding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)
Protein: Low molecular weight protein-tyrosine-phosphatase Wzb (EC 3.1.3.48) (P0AAB2)
Organism: Escherichia coli (strain K12)
Function: Dephosphorylates Wzc. Required for the extracellular polysaccharide colanic acid synthesis, probably involved in the export of colanic acid from the cell to medium. Involved in protection of cells against contact-dependent growth inhibition (CDI), probably due to the loss of a physical impediment to cell-cell contact.
InterPro domains:
- IPR036196: Phosphotyrosine protein phosphatase I superfamily (homologous_superfamily) [1-142]
- IPR023485: Phosphotyrosine protein phosphatase I (domain) [3-141]
- IPR017867: Protein-tyrosine phosphatase, low molecular weight (family) [5-128]
- IPR050438: Low Molecular Weight Phosphotyrosine Protein Phosphatase (family) [3-146]
Sequence:
MFNNILVVCVGNICRSPTAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLILTMEKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYRKSRETFAAVYTLLERSARQWAQALNAEQV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004725 (protein tyrosine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation), GO:0035335 (peptidyl-tyrosine dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)