lokahq/bioreason-rl huggingface dataset:
Protein: Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B) (Q86UV7)
Organism: Homo sapiens (Human)
Function: Not known
InterPro domains:
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [31-40]
- IPR050143: Tripartite motif-containing (family) [12-230]
- IPR000315: B-box-type zinc finger (domain) [84-125]
- IPR027370: Zinc finger, RING-type, eukaryotic (domain) [16-54]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [3-80]
- IPR001841: Zinc finger, RING-type (domain) [16-56]
Sequence:
MAWQVSLLELEDRLQCPICLEVFKESLMLQCGHSYCKGCLVSLSYHLDTKVRCPMCWQVVDGSSSLPNVSLAWVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVSTVCSRMKEELAALFSELKQEQKKVDELIAKLVKNRTRIVNESDVFSWVIRREFQELRHPVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHEFIWKFHSMASR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0043086 (negative regulation of catalytic activity), GO:0051246 (regulation of protein metabolic process), GO:0051336 (regulation of hydrolase activity), GO:0051248 (negative regulation of protein metabolic process), GO:0052547 (regulation of peptidase activity), GO:0045861 (negative regulation of proteolysis), GO:0051346 (negative regulation of hydrolase activity), GO:0030162 (regulation of proteolysis), GO:0052548 (regulation of endopeptidase activity), GO:0010466 (negative regulation of peptidase activity), GO:0010951 (negative regulation of endopeptidase activity), GO:2000116 (regulation of cysteine-type endopeptidase activity), GO:2000117 (negative regulation of cysteine-type endopeptidase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Ligase IV-alpha (Q56AN9)
Organism: Trypanosoma brucei
Function: Not known
InterPro domains:
- IPR012310: DNA ligase, ATP-dependent, central (domain) [188-453]
- IPR016059: DNA ligase, ATP-dependent, conserved site (conserved_site) [397-421]
- IPR025487: Treble clef zinc finger domain (domain) [66-110]
- IPR050326: NAD-dependent DNA ligase B (family) [80-508]
- IPR029319: DNA ligase, OB-like domain (domain) [435-505]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [394-509]
Sequence:
MWRISNLWRRPQLTTLPKDPSLFFGVGRPRTPEQVERYHAMKNTTIESAFPHLAACWVGPSWGTVMLTPHHVAPTCVKSAVWRCSQCLQEFEMSIARFIDQHGTCPLCGKEQRRISSTRNEGPERINGKMSEGDNTDVGITTSPTDATNEEDLELEDVNSLRAPRMTHTNYKSVLHSNPEWEGRNILPMLAQRWELVAEELLHPADTEEQESLLVSPKIDGIRCLIGYNKSQKKLQFFSRSGILLECCHGLVPHAMPLFKADPSLLLDGELFAPHCGFERLSGLVRRLEKFTTQTTRRKQAKLLEYFAFDIMASDQLSSPDAPFSERYRLLKELIPHSGADRVFDTMKPNGRRNHQLEKEELSSRKKIPKLYHVPATLVSPDEVESVLEKACSQGYEGVIIRRPKFPYEHGKRSLGLLKYKYMHDAEYRIVDFLPGNGKFEGGLGAFVCETSTGIRFNATPKTTTKRRLELWAERDRLLGKYLTVQYQELSSQDVPRFPIAKCVRGESEKDWL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016874 (ligase activity), GO:0016886 (ligase activity, forming phosphoric ester bonds), GO:0140097 (catalytic activity, acting on DNA), GO:0003909 (DNA ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0140053 (mitochondrial gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0000963 (mitochondrial RNA processing), GO:0000959 (mitochondrial RNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0020023 (kinetoplast), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: C6orf182 protein (Centrosomal protein 57 like 1) (Chromosome 6 open reading frame 182, isoform CRA_c) (Q6P2R3)
Organism: Homo sapiens (Human)
Function: Not known
InterPro domains:
- IPR051756: Centrosomal microtubule-associated protein (family) [2-248]
- IPR025913: Cep57 centrosome localisation domain (domain) [54-231]
Sequence:
MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKVCI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0007059 (chromosome segregation), GO:0044085 (cellular component biogenesis), GO:0007051 (spindle organization), GO:0051225 (spindle assembly), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: PSP1 C-terminal domain-containing protein (Q38A41)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
InterPro domains:
- IPR047767: PSP1-like (family) [58-456]
Sequence:
MEHEIHKGMEAIVEQSGDNRASGEVNAESNVHSPASVTAKDGCEFARRRISTRGIRGSVRSPYYSPTRSSAMSPVGNGEKGDQEKEEGEGAAEPDVVPDIDVIPRYRSHPNRSQGSFSHLTYNVHSPAHSRMSSYERISWDSQAWKDVFPENAFLGDQSKDLLRLPHSSMDFYHGSPTQQCRKHVRSLATWGKVEGDGSPELLATRNSSPMRPAGCQSLVSTLDALPEPIYETAPLGHQHCFSLSSRKDAAYLKTEAGGEATAVTNEAGEQPSKGPAMTHVLVAFKSLYGVYYVPEAQWGTIGIGDLVSVESHSGENTGKVICDLTHIMSEASHMPAEMAQCPRHVLWPEDASAPLETINPKTNEEVLQRLPRVLRRGMNKGKKRLYYARRRENEALDVGNRLVRDRNFNLALTSVEYQVDFKRITVFCKGDRSHVDPSEVLIFSQQLASSLRGSIVSVVFANEIPERLDVTGSITKAAFQDIYTDALAKIKEAESAQPQRQASSSPVRQSTTAAGGPHNNMRASHIYPDPQLAAMNHTPLMPFYGVPPPFSPPVAPGAPPLMNAVGMNGLYGMTGVPPMNWGMPTPPPYIPPHLPQNVPGRM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: CNR2 (O88690)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
InterPro domains:
- IPR050174: Protocadherin/Cadherin-related Cell Adhesion (family) [17-769]
- IPR002126: Cadherin-like (domain) [21-678]
- IPR031904: Cadherin, C-terminal catenin-binding domain (domain) [796-929]
- IPR013164: Cadherin, N-terminal (domain) [30-111]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [30-670]
- IPR020894: Cadherin conserved site (conserved_site) [230-563]
Sequence:
MDFTTEGRLGTRCMLLSLLLLAAWEAGSGQLHYSVPEEPKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVEVEVRDINDNPPVFSVKEQRMLIYESRLPDSLFPLEGASDADVGLNSMLTYKLSPSEYFGLDVKSNSDGNKQIRLLLKKSLDREDAPEHKLLLTATDGGKPELTGSVQLLVTVLDVNDNAPTFQHPEYEVRILENSDNGTTVIRLNASDKDEGTNSAISYSFNRLVPPKTLEQFSIDADTGEIITQGNLDFEQVDVYKIHVDATDKGHPPMVGHCTVLVKVLDENDNVPQITLTSLSLPVREDAALSTVIALISVSDLDSGSNGQVTCSLSPHVPFKLVSTFKNYYSLVLDSALDRETTADYQVVVTARDGGSPSLWTTASVSVEVADVNDNAPSFAQPDYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGERLLSSYVSVHAESGKVFALQPLDHEELELLQFQVSARDAGVPALGSNVTLQVFVLDENDNAPTLLGPWTPGSGGVVSELVSPSVGAGQVVTKVRAVDADSGYNAWLSYELHPLAGGTRSLFRVGLYTGEISTTRALEEADAPRHRLLVLVKDHGEPALIATATVLVSLVENSQTPKASSRAQGATGQEVSLVNVNVYLIIAICAVSSLLVLTLMVYTALRCSVPPTEGVCGAGKPVLVCSSAVGSWSYSQQRRQKVCSGEGPPKTDLMAFSPSLPPCPVVGEHQDLNDDHCSRPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0098609 (cell-cell adhesion), GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules), GO:0007156 (homophilic cell adhesion via plasma membrane adhesion molecules)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Hyaluronidase-5 (Hyal-5) (EC 3.2.1.35) (Hyaluronoglucosaminidase-5) (Q812F3)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of hyaluronan into smaller oligosaccharide fragments. Does not appear to be essential for fertilization.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16330764, ECO:0000269|PubMed:16925524}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:16330764, ECO:0000269|PubMed:16925524}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269|PubMed:16330764}. Secreted {ECO:0000269|PubMed:16330764}. Note=Located on the plasma and acrosomal membranes of acrosome-intact (AI) sperm and released during the acrosome reaction. {ECO:0000269|PubMed:16330764}.
InterPro domains:
- IPR018155: Hyaluronidase (family) [1-525]
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [48-368]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [38-456]
- IPR001439: Hyaluronidase PH20/Hyaluronidase-5 (family) [1-519]
Sequence:
MRVLYFKHSFFRSLLKSNGLPQTLLVFLLIPCYLTVDFRAPPLIPDVPFLWAWNAPTESCFTRFNQPLDLGLFSLVGSPRKSATGQPVTIFYSDRLGLYPYIDDSQLIFNGGLPQLVSLKSHLEVAKTDILHYMPIDNVGLAVIDWEEWRPTWARNWKPKDIYRNKSIELVQQQNILLNFTEAVKWAKEEFEEAARHFMEETLRLGKSLRPNHLWGFYLFPDCYNNKFQVADYKGECPDIEKHRNDALFWIWEESTALYPSIYLKSSLKSSPQAALYVRNRVQEAIRVSKVKDPRNPLPIFVYFRIVFTDLTYQYLYEDDLVNTIGETIALGTSGMVMWGTLSLSQTMKSCLDLHDYLKTILNPYIINVTLAAKMCSQTLCQNQGVCSRKDWNSNDYLHLNPQNFQIHFVKHGKYEIRGNPTLENLLYFSQKFRCSCFAHLNCQERADIESVSTVSVCTLEDICINSLVISDKSELPKDWNRPYFVNSNQSDITSSATVSPCVPRKDVSGYLVVLSLYSQHLKYSL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015929 (hexosaminidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0000003 (reproduction), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0009566 (fertilization), GO:0007338 (single fertilization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0009897 (external side of plasma membrane), GO:0030141 (secretory granule), GO:0098857 (membrane microdomain), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0045121 (membrane raft), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0001669 (acrosomal vesicle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)
Protein: Methylsterol monooxygenase 2-2 (EC 1.14.18.11) (EC 1.14.18.9) (Sterol 4-alpha-methyl-oxidase 1) (AtSMO1) (Sterol 4-alpha-methyl-oxidase 2-2) (Q8VWZ8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Non-heme iron oxygenase involved in sterols biosynthesis by catalyzing the removal of the second methyl group at the C-4 position. 24-ethylidenelophenol and 24-ethyllophenol are the preferred substrates. Together with SMO2-1, required during embryogenesis, probably by maintaining sterols and auxin homeostasis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27006488}; Multi-pass membrane protein {ECO:0000255}.
InterPro domains:
- IPR006694: Fatty acid hydroxylase (domain) [113-247]
- IPR050307: Sterol Desaturase and Related Enzymes (family) [9-255]
Sequence:
MASFVESGWQYLVTHFSDFQLACIGSFLLHESVFFLSGLPFIFLERQGFLSKYKIQTKNNTPAAQGKCITRLLLYHFSVNLPLMLASYPVFRAMGMRSSFPLPSWKEVSAQILFYFIIEDFVFYWGHRILHSKWLYKNVHSVHHEYATPFGLTSEYAHPAEILFLGFATIVGPALTGPHLITLWLWMVLRVLETVEAHCGYHFPWSLSNFLPLYGGADFHDYHHRLLYTKSGNYSSTFVYMDWIFGTDKGYRRLKTLKENGDMKQT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016716 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0016125 (sterol metabolic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0030258 (lipid modification), GO:1901362 (organic cyclic compound biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0008202 (steroid metabolic process), GO:0016126 (sterol biosynthetic process), GO:0034440 (lipid oxidation), GO:0006694 (steroid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)
Protein: Prosaposin receptor GPR37 (Endothelin B receptor-like protein 1) (ETBR-LP-1) (G-protein coupled receptor 37) (Parkin-associated endothelin receptor-like receptor) (PAELR) (O15354)
Organism: Homo sapiens (Human)
Function: Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.
Subcellular location: Cell projection, dendrite {ECO:0000269|PubMed:25977097}. Synapse {ECO:0000269|PubMed:25977097}. Cell membrane {ECO:0000269|PubMed:17059562, ECO:0000269|PubMed:25977097, ECO:0000269|PubMed:26869225}; Multi-pass membrane protein {ECO:0000269|PubMed:17059562}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17059562}; Multi-pass membrane protein {ECO:0000269|PubMed:17059562}.
InterPro domains:
- IPR003909: G protein-coupled receptor 37 orphan (family) [12-613]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [278-549]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [263-557]
Sequence:
MRAPGALLARMSRLLLLLLLKVSASSALGVAPASRNETCLGESCAPTVIQRRGRDAWGPGNSARDVLRARAPREEQGAAFLAGPSWDLPAAPGRDPAAGRGAEASAAGPPGPPTRPPGPWRWKGARGQEPSETLGRGNPTALQLFLQISEEEEKGPRGAGISGRSQEQSVKTVPGASDLFYWPRRAGKLQGSHHKPLSKTANGLAGHEGWTIALPGRALAQNGSLGEGIHEPGGPRRGNSTNRRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKEDLGFSGRAPAERCIIKISPDLPDTIYVLALTYDSARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKACTRGNKRQIQLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGVSQQTMDLLNIISQFLLFFKSCVTPVLLFCLCKPFSRAFMECCCCCCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHC
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0005515 (protein binding), GO:0042277 (peptide binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0010646 (regulation of cell communication), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0009966 (regulation of signal transduction), GO:0008277 (regulation of G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Cytochrome b5 isoform B (AtCb5-B) (Cytochrome b5 isoform 2) (Cytochrome b5 isoform E) (AtCb5-E) (O48845)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases, including fatty acid desaturases.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19054355, ECO:0000269|PubMed:22773744}; Single-pass membrane protein {ECO:0000269|PubMed:19054355, ECO:0000269|PubMed:22773744}; Cytoplasmic side {ECO:0000269|PubMed:19054355, ECO:0000269|PubMed:22773744}.
InterPro domains:
- IPR050668: Cytochrome b5 (family) [4-130]
- IPR001199: Cytochrome b5-like heme/steroid binding domain (domain) [5-81]
- IPR018506: Cytochrome b5, heme-binding site (binding_site) [36-43]
- IPR036400: Cytochrome b5-like heme/steroid binding domain superfamily (homologous_superfamily) [2-93]
Sequence:
MGDEAKIFTLSEVSEHNQAHDCWIVINGKVYNVTKFLEDHPGGDDVLLSSTGKDATDDFEDVGHSESAREMMEQYYVGEIDPTTIPKKVKYTPPKQPHYNQDKTSEFIIKLLQFLVPLAILGLAVGIRIYTKSG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:0044107 (cellular alcohol metabolic process), GO:0016125 (sterol metabolic process), GO:1902652 (secondary alcohol metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0008204 (ergosterol metabolic process), GO:0008202 (steroid metabolic process), GO:0097384 (cellular lipid biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0044108 (cellular alcohol biosynthetic process), GO:0046165 (alcohol biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0016128 (phytosteroid metabolic process), GO:0006696 (ergosterol biosynthetic process), GO:0006694 (steroid biosynthetic process), GO:0016126 (sterol biosynthetic process), GO:0016129 (phytosteroid biosynthetic process), GO:1902653 (secondary alcohol biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)