Protein: Nucleotide-binding oligomerization domain-containing protein 2 (A6KD97)
Organism: Rattus norvegicus (Rat)
Function: Regulatory part that prevents formation of the Nlrp1a inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of Nlrp1a (NACHT, LRR and PYD domains-containing protein 1a, C-terminus), preventing activation of the Nlrp1a inflammasome. In response to pathogen-associated signals, this part is ubiquitinated by the N-end rule pathway and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the Nlrp1a inflammasome
Subcellular location: Basolateral cell membrane. Cell membrane; Lipid-anchor. Cytoplasm, cytosol. Inflammasome. Lateral cell membrane. Membrane; Lipid-anchor. Mitochondrion
InterPro domains:
- IPR011029: Death-like domain superfamily (homologous_superfamily) [2-183]
- IPR007111: NACHT nucleoside triphosphatase (domain) [266-435]
- IPR041075: NOD1/2, winged helix domain (domain) [519-569]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [715-932]
- IPR041267: NACHT, LRR and PYD domains-containing protein, helical domain HD2 (domain) [576-729]
- IPR001611: Leucine-rich repeat (repeat) [790-864]
- IPR001315: CARD domain (domain) [1-191]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [188-448]
- IPR051261: NOD-like receptor (family) [243-932]
Sequence:
MCSQEDFQAQRSQLVALLVSGSLEGFESILDWLLSWDVLSREDYEGLSLPGQPLSHSARRLLDTVCNKGVWGCQKLFEAVQEAQANSHTFELQGCWDVHSLHPTRDLQSHRPAIVRRLCSHVEAILELARDEGFLSQYECEEIRLPIFTSSQRARRLLDLAAVKANGLAAFLLQHVRKLPASLSLPYEAAECQKFTAKLRTMVSAQSRFLSTYDGSENLCLEDIYTENTLELRTEVGTAGALQKSPATLGLEELFGTHGHLNKDADTILVVGEAGSGKSTLLQRLHLLWASGQNFREFLFIFPFSCRQLQCMTKPLSLRTLLFEHCCWPDVGQDDVFQFLLDHPDRVLLTFDGLDEFKFRFTDRERHCSPLDPTSVQTLLFNLLQGNLLKNACKVLTSRPDAVSALLRKFVRTECHLKGFSEEGIKLYLRKHHREPGVADRLIHLIQATSALHGLCHLPVFSWMVSRCHRELLLQNRGFPTTSTDMYLLILQHFLLHASPPDSFPLGLGPGLLQSRLSTLLHLGHLALQGLAMSCYVFSAQQLQAAQVDSEDISLGFLVRAQSVVPGSKAPLEFLHITFQCFFAAFYLAVSADTSAASLKHLFSCGRPGNSLLLRLLPNLCIQGSRVKGGQAALLQKAEPHNLQITAAFLAGLLSQQHRDLLAACQVPERVLLQRQARARSCLAHSLREHFHSIPPAVPGETKSMHAMPGFIWLIRSLYEMQEVQLAREAVRRLDIGHLKLTFCRVGPAECAALAFVLQHLQRPVALQLDHNSVGDVGVEQLLPCLGVCTALYLRDNNISDRGARTLVECALRCEQLQKLALFNNKLTDGCASSVAKLLAHKQNFLSLRVGNNHITAAGAEVLAQGLKSNTSLQFLGFWGNSVGDKGSQALAEVVADHQRLKWLSLVGNNIGSVGAHALALMLEKNKSLEEL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0033218 (amide binding), GO:0097367 (carbohydrate derivative binding), GO:0042277 (peptide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009607 (response to biotic stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0009719 (response to endogenous stimulus), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0051707 (response to other organism), GO:0009991 (response to extracellular stimulus), GO:0042127 (regulation of cell population proliferation), GO:0043207 (response to external biotic stimulus), GO:0007584 (response to nutrient), GO:0010604 (positive regulation of macromolecule metabolic process), GO:1901698 (response to nitrogen compound), GO:0002702 (positive regulation of production of molecular mediator of immune response), GO:0002697 (regulation of immune effector process), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0002700 (regulation of production of molecular mediator of immune response), GO:1901700 (response to oxygen-containing compound), GO:0001819 (positive regulation of cytokine production), GO:0002699 (positive regulation of immune effector process), GO:0001817 (regulation of cytokine production), GO:0071216 (cellular response to biotic stimulus), GO:0010033 (response to organic substance), GO:0008284 (positive regulation of cell population proliferation), GO:0071417 (cellular response to organonitrogen compound), GO:1901652 (response to peptide), GO:0071219 (cellular response to molecule of bacterial origin), GO:0010243 (response to organonitrogen compound), GO:0002703 (regulation of leukocyte mediated immunity), GO:0071310 (cellular response to organic substance), GO:0031667 (response to nutrient levels), GO:0002718 (regulation of cytokine production involved in immune response), GO:0032494 (response to peptidoglycan), GO:1901699 (cellular response to nitrogen compound), GO:0002237 (response to molecule of bacterial origin), GO:0010628 (positive regulation of gene expression), GO:0014070 (response to organic cyclic compound), GO:0002705 (positive regulation of leukocyte mediated immunity), GO:1901701 (cellular response to oxygen-containing compound), GO:0010468 (regulation of gene expression), GO:0002720 (positive regulation of cytokine production involved in immune response), GO:0071407 (cellular response to organic cyclic compound), GO:0032495 (response to muramyl dipeptide)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)