Protein: Anion exchange protein (A0A8M9Q3P6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH
Subcellular location: Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Lateral cell membrane; Multi-pass membrane protein. Membrane; Multi- pass membrane protein
InterPro domains:
- IPR016152: Phosphotransferase/anion transporter (homologous_superfamily) [106-447]
- IPR003020: Bicarbonate transporter, eukaryotic (family) [109-1061]
- IPR011531: Bicarbonate transporter-like, transmembrane domain (domain) [477-1041]
- IPR003024: Sodium bicarbonate cotransporter (family) [142-613]
- IPR013769: Band 3 cytoplasmic domain (domain) [111-423]
Sequence:
MSAGKRVEDEAVLDRGASLLKPLCDQEEVEGHHTIYIGVHVPKSYRRRRRHRRRTSHKDRKEKVSENTSDRSDAENNEEASNSILKPLISPAAERIRFILGEDDDSPAPPQLFTELDELLSVDGQEMEWKETARWIKFEEKVEKGGERWSKPHVATLSLHSLFELRTCIEKGTIMLDLEASTLPGVVEMITDSQIESGLLKADLKEKVMYTLLRKHRHQTKKSNLRSLADIGKTVSSASRLFSTPDNARNPLESSVPCLTTRTSEEVLRVPGSPSMGWPSSPTTAHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDSPFVAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHEIAYKAKDRQDLLAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYAGGDSTQMNGDTPHSGGHGGGGHAVGDELKKTGKFCGGLILDVKRKVPFFFSDFYDSLHIQSLSAILFIYLGTVTNAITFGGLLGDATENMQGVLESFLGTAVTGAVFCLLAGQPLIILSSTGPVLVFERLLFNFSRENDFDYLEFRLWIGLWSAFFCLVLVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMLKLAHYYPINSDFKIDYVTQYDCMCMAPTDANSSDVYTDPLDSTFVWTVNYTTDPRMNATWSSLSKKECLKYGGELVGKACEFVPDITLMSFILFFGTYTCSMCLKKFKTSPFFPTTVRKLISDFAIILAILIFCGVDALVGVETPKLIVPSEFKPTSPNRGWFVPPFGGNPWWVYLGASVPALLVTILLFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAVLLAVCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGVMVFILTGISVFMSPVLKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPAKHQPDLIYLRHVPLRKVHLFTFVQLLCLALLWVLKSTVAAIIFPVMILALVAVRKALDYIFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKQGSIDSDMEDSDYPYNENVPSIKIPMDMMEQEPFLGDKASDREKSASILDRYSSC
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015106 (bicarbonate transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015293 (symporter activity), GO:0140410 (solute:bicarbonate symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015370 (solute:sodium symporter activity), GO:0008510 (sodium:bicarbonate symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0006820 (monoatomic anion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)