Protein: Gamma-aminobutyric acid receptor subunit rho-1 isoform X1 (A0A8M2B753)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Multi- pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Synaptic cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR006201: Neurotransmitter-gated ion-channel (family) [61-463]
- IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [66-265]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [57-265]
- IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [263-465]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [273-409]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [267-463]
- IPR018000: Neurotransmitter-gated ion-channel, conserved site (conserved_site) [183-197]
- IPR006028: Gamma-aminobutyric acid A receptor/Glycine receptor alpha (family) [269-463]
Sequence:
MHADVCFLLCACFLCTGALQSCSKSRSKRETTRAERDLHKPGSTLLMRSPDVTKAPVTKSEQLLKLDDHDFTMRPGFGGPAIPVGVDVQLESLDTISEVDMDFTMTLYLRHYWKDARLSFPSNTNQSMTFDGRLVKKIWVPDIFFVHSKRSFIHDTTTENVMLRVHPDGKVLYSLRVTVTSMCNMDLSHFPLDTQTCSLEIESYAYTDDDLMLYWKRGNKSLQTDDKISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVIEYAAVNYLSTLQERKERSQNSRLPCTCGMTHPGQMMMSSSYSEMDMMTTGNYGMSELSDTKQEQFLVHLVMDNEQGAQRPAVTTSSTLNIDTHAIDKYSRVIFPGAYTLFNIIYWSIYSQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0060089 (molecular transducer activity), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0030594 (neurotransmitter receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0015108 (chloride transmembrane transporter activity), GO:0016917 (GABA receptor activity), GO:0022835 (transmitter-gated channel activity), GO:0015267 (channel activity), GO:0022824 (transmitter-gated monoatomic ion channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0005253 (monoatomic anion channel activity), GO:0022836 (gated channel activity), GO:0022851 (GABA-gated chloride ion channel activity), GO:0005254 (chloride channel activity), GO:0099095 (ligand-gated monoatomic anion channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0045786 (negative regulation of cell cycle), GO:0010948 (negative regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0031099 (regeneration), GO:0070316 (regulation of G0 to G1 transition)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)