Protein: Transcription factor PU.1 isoform X1 (A0A8M2BG46)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
- IPR000418: Ets domain (domain) [198-286]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [185-284]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [168-297]
- IPR046328: ETS family (family) [77-282]
Sequence:
MLHPYRMEGYIIPPKEEGRERVTWTGWMSQTPSVQKDYWAVLTKDQQTEEMFETEIYRPPMEYQYIIDDSQNDHSWDYNTHHIHPVDFENLPESHFTELQSVQSLHAASVHRFPDVESSHFMDPGLGSHHIPLTNPQMTYLPRTSVCYPHNVQPSPLQRSSDEEDPSSRSPPLEVSDEECMRDHISSTTGGEHGNKKKIRLYQFLLDLLRNGDMKDSIWWVDREKGTFQFSSKHKEVLANRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKIKKKLTYQFSGEVLGKSHTDRKHYM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0019222 (regulation of metabolic process), GO:0002683 (negative regulation of immune system process), GO:0006955 (immune response), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0002252 (immune effector process), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:0048871 (multicellular organismal-level homeostasis), GO:0048523 (negative regulation of cellular process), GO:0002262 (myeloid cell homeostasis), GO:2000026 (regulation of multicellular organismal development), GO:0034101 (erythrocyte homeostasis), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0002366 (leukocyte activation involved in immune response), GO:0045596 (negative regulation of cell differentiation), GO:0002263 (cell activation involved in immune response), GO:0060255 (regulation of macromolecule metabolic process), GO:0045595 (regulation of cell differentiation), GO:1903706 (regulation of hemopoiesis), GO:0002274 (myeloid leukocyte activation), GO:1903707 (negative regulation of hemopoiesis), GO:0048872 (homeostasis of number of cells), GO:0045637 (regulation of myeloid cell differentiation), GO:0030097 (hemopoiesis), GO:1902106 (negative regulation of leukocyte differentiation), GO:0002521 (leukocyte differentiation), GO:0045638 (negative regulation of myeloid cell differentiation), GO:0030218 (erythrocyte differentiation), GO:0060284 (regulation of cell development), GO:0042116 (macrophage activation), GO:1902105 (regulation of leukocyte differentiation), GO:0010628 (positive regulation of gene expression), GO:0002275 (myeloid cell activation involved in immune response), GO:0010721 (negative regulation of cell development), GO:0030099 (myeloid cell differentiation), GO:0010468 (regulation of gene expression), GO:0002762 (negative regulation of myeloid leukocyte differentiation), GO:0061515 (myeloid cell development), GO:0048821 (erythrocyte development), GO:0002281 (macrophage activation involved in immune response), GO:0002573 (myeloid leukocyte differentiation), GO:0002761 (regulation of myeloid leukocyte differentiation), GO:0045646 (regulation of erythrocyte differentiation), GO:0030851 (granulocyte differentiation), GO:0030852 (regulation of granulocyte differentiation), GO:0030225 (macrophage differentiation), GO:0030223 (neutrophil differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)