Protein: X-ray repair cross-complementing protein 5 (A6KFI3)
Organism: Rattus norvegicus (Rat)
Function: Single-stranded DNA-dependent ATP-dependent helicase
Subcellular location: Nucleus
InterPro domains:
- IPR005160: Ku70/Ku80 C-terminal arm (domain) [477-569]
- IPR006164: Ku70/Ku80, DNA-binding domain (domain) [253-453]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [2-242]
- IPR014893: Ku, C-terminal (domain) [594-706]
- IPR016194: SPOC-like, C-terminal domain superfamily (homologous_superfamily) [242-542]
- IPR024193: Ku80 (family) [3-707]
- IPR036494: Ku, C-terminal domain superfamily (homologous_superfamily) [561-711]
- IPR005161: Ku70/Ku80, N-terminal alpha/beta (domain) [9-243]
Sequence:
MAWSGNKAAVVLCMDVGVAMGNSFPGEESPLEQAKKVMTMFVQRQVFSESKDEIALVLYGTESTDNALAGKDQYQNITVHRHLMLPDFDLLEDIGNKIQPSSQQADFLDALIVCMDLIQRETIGKKFGKKHIEVFTDLSSPFSQDQLDIIICNLKKSSISLQFFLPFPIDKNGEPGETEDHDSSFDHCAPSFPQKGLTEQQKEGIHMVTRVMLSLEGKDGLDEIYSFSESLQQLCIFKKIERRSLPWPCQLTIGPNLSIRIVAYKSIVQEKFKKSWVVVDARTLKKEDIQKETVYCLNDDDETEVSKEDTIQGFRYGSDIIPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVHRRFFMGHQVLKVFAAKDDEAAAVALSSLVHALDELNMVAIVRYAYDKRANPQVGVAFPFIKDAYECLVYVQLPFMEDLRQYMFSSLKNNKKCTPTEAQLSAIDDLIDSMSLVKKNEEEDIIEDLFPTSKIPNPEFQRLYQCLLHRALHLQERLPPIQQHILNMLDPPTEMKAKCEIPLSKVKTLFPLTEVVKKKDQVTAQDVFQDNIEEGPAAKKYKTEKEEGHISISSLAEGNVTKVGSVNPVENFRVLVRQKIASFEEASLQLMSHIEQFLDTNETLYFMKSMDCIKALREEAIQFSEEQRFNSFLEGLREKVEIKQLNHFWEIVVQDGITLITKDESPGSSVTAEEATKFLTPKDKAKEDTTGLEEGGDVDDLLDMI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0104004 (cellular response to environmental stimulus), GO:0060322 (head development), GO:0009410 (response to xenobiotic stimulus), GO:0009314 (response to radiation), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0006970 (response to osmotic stress), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0071478 (cellular response to radiation), GO:0007420 (brain development), GO:0007399 (nervous system development), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0062197 (cellular response to chemical stress), GO:0071470 (cellular response to osmotic stress), GO:0007417 (central nervous system development), GO:0009651 (response to salt stress), GO:0010212 (response to ionizing radiation), GO:1901701 (cellular response to oxygen-containing compound), GO:0070542 (response to fatty acid), GO:0006972 (hyperosmotic response), GO:0071479 (cellular response to ionizing radiation), GO:0010165 (response to X-ray), GO:0042538 (hyperosmotic salinity response), GO:0071398 (cellular response to fatty acid), GO:0071472 (cellular response to salt stress), GO:0071474 (cellular hyperosmotic response), GO:0071396 (cellular response to lipid), GO:0071481 (cellular response to X-ray), GO:0071475 (cellular hyperosmotic salinity response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:1990391 (DNA repair complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)