Protein: Serine/threonine-protein phosphatase 2A activator (A0A804CD06)
Organism: Homo sapiens (Human)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Subcellular location: Cytoplasm
InterPro domains:
- IPR004327: Phosphotyrosyl phosphatase activator, PTPA (family) [61-370]
- IPR037218: PTPA superfamily (homologous_superfamily) [64-368]
- IPR043170: Phosphotyrosyl phosphatase activator, C-terminal lid domain (homologous_superfamily) [262-372]
Sequence:
MSSKLLEPAGAHLSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPYLEPRHFVDEKAVNENHKDYMFLECILFITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTSG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0019899 (enzyme binding), GO:0004722 (protein serine/threonine phosphatase activity), GO:0019900 (kinase binding), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0010942 (positive regulation of cell death), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:0060255 (regulation of macromolecule metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010941 (regulation of cell death), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0043086 (negative regulation of catalytic activity), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:0051336 (regulation of hydrolase activity), GO:0043068 (positive regulation of programmed cell death), GO:0051248 (negative regulation of protein metabolic process), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:0051174 (regulation of phosphorus metabolic process), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0051346 (negative regulation of hydrolase activity), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:0010921 (regulation of phosphatase activity), GO:0045937 (positive regulation of phosphate metabolic process), GO:0019220 (regulation of phosphate metabolic process), GO:0051345 (positive regulation of hydrolase activity), GO:0031401 (positive regulation of protein modification process), GO:0045936 (negative regulation of phosphate metabolic process), GO:0010923 (negative regulation of phosphatase activity), GO:0043666 (regulation of phosphoprotein phosphatase activity), GO:0035306 (positive regulation of dephosphorylation), GO:0035303 (regulation of dephosphorylation), GO:0035308 (negative regulation of protein dephosphorylation), GO:0010922 (positive regulation of phosphatase activity), GO:0035304 (regulation of protein dephosphorylation), GO:0035307 (positive regulation of protein dephosphorylation), GO:0035305 (negative regulation of dephosphorylation), GO:0032515 (negative regulation of phosphoprotein phosphatase activity), GO:0032516 (positive regulation of phosphoprotein phosphatase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)