Protein: FAS-associated death domain protein (M0R9V8)
Organism: Rattus norvegicus (Rat)
Function: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling
InterPro domains:
- IPR011029: Death-like domain superfamily (homologous_superfamily) [1-180]
- IPR016729: FAS-associated death domain protein (family) [2-190]
- IPR049634: FADD, vertebrates (family) [1-185]
- IPR001875: Death effector domain (domain) [2-83]
- IPR000488: Death domain (domain) [87-181]
Sequence:
MDPFLVLLHSLSSSLSGNDLTDLKFLCRERVSKRKLERVQSGLDLFSVLLEQNDLERGHTGLLRELLASLGRHDLLQRLDDFEAGATTAATPGEADLRVAFDIVCDNVGRDWKRLARELKVSEAKIDGIEERYPRSLSDRVRETLRVWKNVEKENASVAGLVKALRACRLNLVADLVEEALMAQGSVSKSDDTSSALRDSTVSFSETP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0005102 (signaling receptor binding), GO:0033612 (receptor serine/threonine kinase binding), GO:0005126 (cytokine receptor binding), GO:0002020 (protease binding), GO:0032813 (tumor necrosis factor receptor superfamily binding), GO:0005123 (death receptor binding), GO:0005164 (tumor necrosis factor receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0007610 (behavior), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0048731 (system development), GO:0048513 (animal organ development), GO:1901700 (response to oxygen-containing compound), GO:0030534 (adult behavior), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0072001 (renal system development), GO:0043278 (response to morphine), GO:0042220 (response to cocaine), GO:0010243 (response to organonitrogen compound), GO:0043067 (regulation of programmed cell death), GO:0048148 (behavioral response to cocaine), GO:0014070 (response to organic cyclic compound), GO:0001822 (kidney development), GO:0010939 (regulation of necrotic cell death), GO:0043279 (response to alkaloid), GO:0014072 (response to isoquinoline alkaloid), GO:0062098 (regulation of programmed necrotic cell death), GO:0060544 (regulation of necroptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0098797 (plasma membrane protein complex), GO:0005886 (plasma membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0098857 (membrane microdomain), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0045121 (membrane raft), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)