Protein: Rho guanine nucleotide exchange factor 9 (A0A8M9QB25)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as a guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters
InterPro domains:
- IPR035728: Rho guanine nucleotide exchange factor 9, SH3 domain (domain) [574-631]
- IPR000219: Dbl homology domain (domain) [703-887]
- IPR001849: Pleckstrin homology domain (domain) [918-1027]
- IPR001452: SH3 domain (domain) [575-634]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [693-909]
- IPR055251: SOS1/NGEF-like, PH domain (domain) [913-1022]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [573-665]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [910-1063]
Sequence:
MRNSSTGSNRRKLFRPGSGPLHVNMLISGGSVVSAEAVWDHVTMAERELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRVDPHPPQPYTKPVFYINPIATPRFHNTTAKLWVNQENIATESAEGASEVQNGHTDPSNGCLCIGQPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLRQCRKRIDMFNDDQLKVIFGNIEDIYRFQMGFVRDLEKQYNIEEPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDGRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQEHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGDDILDRSSELIYTGEMSWIYQPYGRSQQRVFFLFDHQLVLCKKDLIRRDILYYKGRIDMDRYAVRDAIDGRDDDFNVSVKNAFKLHNRDSDEIHIFLAKKPEEKIRWLRAFHEERKMVQEDEKIGFEISEYQKKQAAMTVRKVTKQKGVSQSRCVSPSDPSSHGPFVLSDDMQQSDLVEFHVSKSGQSPFWQNFNKFTSKNGKK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0140678 (molecular function inhibitor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0016043 (cellular component organization), GO:0035239 (tube morphogenesis), GO:0044085 (cellular component biogenesis), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0030030 (cell projection organization), GO:0048514 (blood vessel morphogenesis), GO:0002040 (sprouting angiogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0022607 (cellular component assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0046847 (filopodium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton)