Protein: Patched homolog 1 (Drosophila), isoform CRA_a (A6KQC5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR000731: Sterol-sensing domain (domain) [424-584]
- IPR004766: Transmembrane receptor, patched (family) [29-888]
- IPR053958: HMGCR/SNAP/NPC1-like, sterol-sensing domain (domain) [450-601]
Sequence:
MASAGNAAGALGRQAGGGRRRRTGGPHRAAPDRDYLHRPSYCDAAFALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYEHFRGYDYVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTEPHSNTRYSPPPPYSSHSFAHETHITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTITQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHKSFSSVKYVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQVFVS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0036094 (small molecule binding), GO:0006576 (biogenic amine metabolic process), GO:0044877 (protein-containing complex binding), GO:0038023 (signaling receptor activity), GO:0097159 (organic cyclic compound binding), GO:0042562 (hormone binding), GO:0008289 (lipid binding), GO:0043178 (alcohol binding), GO:0005496 (steroid binding), GO:0004888 (transmembrane signaling receptor activity), GO:0005102 (signaling receptor binding), GO:0032934 (sterol binding), GO:0015485 (cholesterol binding), GO:0001664 (G protein-coupled receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0048609 (multicellular organismal reproductive process), GO:0032989 (cellular component morphogenesis), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048468 (cell development), GO:0009410 (response to xenobiotic stimulus), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048515 (spermatid differentiation), GO:0048608 (reproductive structure development), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0007283 (spermatogenesis), GO:0000902 (cell morphogenesis), GO:0016043 (cellular component organization), GO:0009612 (response to mechanical stimulus), GO:0006935 (chemotaxis), GO:0031099 (regeneration), GO:0061458 (reproductive system development), GO:0030030 (cell projection organization), GO:0032355 (response to estradiol), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0048732 (gland development), GO:0001655 (urogenital system development), GO:0007286 (spermatid development), GO:0061008 (hepaticobiliary system development), GO:0048666 (neuron development), GO:0031100 (animal organ regeneration), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0033993 (response to lipid), GO:0030850 (prostate gland development), GO:0014070 (response to organic cyclic compound), GO:0048858 (cell projection morphogenesis), GO:0048232 (male gamete generation), GO:0030182 (neuron differentiation), GO:0032526 (response to retinoic acid), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0007411 (axon guidance), GO:0001889 (liver development), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0097421 (liver regeneration), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0071679 (commissural neuron axon guidance), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0044292 (dendrite terminus), GO:0042995 (cell projection), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0030427 (site of polarized growth), GO:0036477 (somatodendritic compartment), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0030426 (growth cone), GO:0043227 (membrane-bounded organelle), GO:0099572 (postsynaptic specialization), GO:0043005 (neuron projection), GO:0098984 (neuron to neuron synapse), GO:0043231 (intracellular membrane-bounded organelle), GO:0014069 (postsynaptic density), GO:0044295 (axonal growth cone), GO:0030425 (dendrite), GO:0032279 (asymmetric synapse), GO:0030424 (axon), GO:0005634 (nucleus)