Protein: Similar to Tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1) (Predicted) (A6JRM7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single- pass type I membrane protein
InterPro domains:
- IPR050122: Receptor Tyrosine Kinase (family) [62-747]
- IPR013098: Immunoglobulin I-set (domain) [61-142]
- IPR000001: Kringle (domain) [310-393]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [474-746]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [611-623]
- IPR000719: Protein kinase domain (domain) [473-746]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [49-153]
- IPR013806: Kringle-like fold (homologous_superfamily) [311-394]
- IPR003598: Immunoglobulin subtype 2 (domain) [70-138]
- IPR018056: Kringle, conserved site (conserved_site) [361-374]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [467-756]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [62-154]
- IPR036790: Frizzled cysteine-rich domain superfamily (homologous_superfamily) [167-301]
- IPR007110: Immunoglobulin-like domain (domain) [42-141]
- IPR016247: Tyrosine-protein kinase, receptor ROR (family) [21-864]
- IPR020067: Frizzled domain (domain) [165-299]
- IPR038178: Kringle superfamily (homologous_superfamily) [302-396]
- IPR003599: Immunoglobulin domain subtype (domain) [64-149]
Sequence:
MHRPRRRGTRPPPLALLAALLLAARGAAAQETELSVSAELVPTSSWNTSSEIDKDSYLTLDEPMNNITTSLGQTAELHCKVSGNPPPNIRWFKNDAPVVQEPRRISFRATNYGSRLRIRNLDTTDTGYFQCVATSGKKVVSTTGVLFVKFGPPPTASPGSSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEVLENVLCHTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHSFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAFLFFFICVCRNNQKSPSPPVQRQPKPVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECTFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYMNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSSLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRFPNYMFPSQGIPPQGQIAGFIGPAIPQNQRFIPINGYPIPPGYAAFPAAHYQPAGPPRVIQHCPPPKSRSPSSASGSTSTGHVASLPSSGSNQEANVPLLPHMSIPNHPGGMGITVFGNKSQKPYKIDSKQPSLLGDSNIHGHTESMISAEV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0004888 (transmembrane signaling receptor activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0019199 (transmembrane receptor protein kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004713 (protein tyrosine kinase activity), GO:0016301 (kinase activity), GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0021782 (glial cell development), GO:0022008 (neurogenesis), GO:0010001 (glial cell differentiation), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0014002 (astrocyte development), GO:0042063 (gliogenesis), GO:0048708 (astrocyte differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032432 (actin filament bundle), GO:0009986 (cell surface), GO:0005737 (cytoplasm), GO:0042641 (actomyosin), GO:0097517 (contractile actin filament bundle), GO:0001725 (stress fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)