Protein: Receptor tyrosine kinase-like orphan receptor 2 (Predicted) (A6J6R2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single- pass type I membrane protein
InterPro domains:
- IPR050122: Receptor Tyrosine Kinase (family) [73-747]
- IPR013098: Immunoglobulin I-set (domain) [63-149]
- IPR000001: Kringle (domain) [314-396]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [474-746]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [611-623]
- IPR000719: Protein kinase domain (domain) [473-746]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [63-163]
- IPR013806: Kringle-like fold (homologous_superfamily) [280-398]
- IPR003598: Immunoglobulin subtype 2 (domain) [74-142]
- IPR018056: Kringle, conserved site (conserved_site) [364-377]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [443-744]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [68-156]
- IPR036790: Frizzled cysteine-rich domain superfamily (homologous_superfamily) [171-303]
- IPR007110: Immunoglobulin-like domain (domain) [55-145]
- IPR016247: Tyrosine-protein kinase, receptor ROR (family) [25-870]
- IPR020067: Frizzled domain (domain) [169-303]
- IPR038178: Kringle superfamily (homologous_superfamily) [304-398]
- IPR003599: Immunoglobulin domain subtype (domain) [68-153]
Sequence:
MARGWVRPSRVPLCVRAVWTAAALLLWTPWTAGEVEDSEAIDTLGQLDGPDSPLPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRVIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGPTHSPNHNFQDDDQEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLENDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGTDYRGMASTTKSGHQCQPWALQHPHSHRLSSTEFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRVELCDVPPCSPRDGSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLISQHKQAKLKEISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEPTQVVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMVFSYCCHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSGRPRFKDIHGRLRSWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYMAPKQKAQPFPQPQFIPMKGQIRPLVPPAQLYIPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSVADRAALLSEGTEDVQNMPEDVAQSPVQEAEEEEEGSVPETELLGDSDTLQVNEAHVHLEA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0060089 (molecular transducer activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0038023 (signaling receptor activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004888 (transmembrane signaling receptor activity), GO:0005102 (signaling receptor binding), GO:0017147 (Wnt-protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0019899 (enzyme binding), GO:0016301 (kinase activity), GO:0019199 (transmembrane receptor protein kinase activity), GO:0019900 (kinase binding), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004713 (protein tyrosine kinase activity), GO:0001664 (G protein-coupled receptor binding), GO:0004714 (transmembrane receptor protein tyrosine kinase activity), GO:0005109 (frizzled binding), GO:0019901 (protein kinase binding), GO:0031435 (mitogen-activated protein kinase kinase kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0002376 (immune system process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0019222 (regulation of metabolic process), GO:0048584 (positive regulation of response to stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0003006 (developmental process involved in reproduction), GO:0001503 (ossification), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0050900 (leukocyte migration), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0051094 (positive regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0097529 (myeloid leukocyte migration), GO:0009967 (positive regulation of signal transduction), GO:0045597 (positive regulation of cell differentiation), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0048608 (reproductive structure development), GO:0050803 (regulation of synapse structure or activity), GO:1903706 (regulation of hemopoiesis), GO:2000026 (regulation of multicellular organismal development), GO:0009888 (tissue development), GO:0050806 (positive regulation of synaptic transmission), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:1903708 (positive regulation of hemopoiesis), GO:0007548 (sex differentiation), GO:0099177 (regulation of trans-synaptic signaling), GO:0080090 (regulation of primary metabolic process), GO:0046661 (male sex differentiation), GO:0030282 (bone mineralization), GO:0051128 (regulation of cellular component organization), GO:0016477 (cell migration), GO:0061458 (reproductive system development), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0050807 (regulation of synapse organization), GO:0051246 (regulation of protein metabolic process), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0050804 (modulation of chemical synaptic transmission), GO:0051968 (positive regulation of synaptic transmission, glutamatergic), GO:0048806 (genitalia development), GO:0021782 (glial cell development), GO:0010001 (glial cell differentiation), GO:0030539 (male genitalia development), GO:0045637 (regulation of myeloid cell differentiation), GO:0022008 (neurogenesis), GO:0045639 (positive regulation of myeloid cell differentiation), GO:0007399 (nervous system development), GO:1902107 (positive regulation of leukocyte differentiation), GO:1905517 (macrophage migration), GO:0051247 (positive regulation of protein metabolic process), GO:1902105 (regulation of leukocyte differentiation), GO:0007417 (central nervous system development), GO:1902533 (positive regulation of intracellular signal transduction), GO:0031214 (biomineral tissue development), GO:0051338 (regulation of transferase activity), GO:0043085 (positive regulation of catalytic activity), GO:0051174 (regulation of phosphorus metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0051347 (positive regulation of transferase activity), GO:0099175 (regulation of postsynapse organization), GO:0031399 (regulation of protein modification process), GO:0014002 (astrocyte development), GO:0045937 (positive regulation of phosphate metabolic process), GO:0019220 (regulation of phosphate metabolic process), GO:0042063 (gliogenesis), GO:0043549 (regulation of kinase activity), GO:0051966 (regulation of synaptic transmission, glutamatergic), GO:0043410 (positive regulation of MAPK cascade), GO:0002763 (positive regulation of myeloid leukocyte differentiation), GO:0031401 (positive regulation of protein modification process), GO:0002761 (regulation of myeloid leukocyte differentiation), GO:0048708 (astrocyte differentiation), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0045649 (regulation of macrophage differentiation), GO:0033674 (positive regulation of kinase activity), GO:0045651 (positive regulation of macrophage differentiation), GO:0045859 (regulation of protein kinase activity), GO:0042327 (positive regulation of phosphorylation), GO:0043406 (positive regulation of MAP kinase activity), GO:0001934 (positive regulation of protein phosphorylation), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0043507 (positive regulation of JUN kinase activity), GO:0045860 (positive regulation of protein kinase activity), GO:0071902 (positive regulation of protein serine/threonine kinase activity), GO:0043405 (regulation of MAP kinase activity), GO:0043506 (regulation of JUN kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0042995 (cell projection), GO:0098794 (postsynapse), GO:0044297 (cell body), GO:0009986 (cell surface), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0099081 (supramolecular polymer), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043228 (non-membrane-bounded organelle), GO:0043005 (neuron projection), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0098978 (glutamatergic synapse), GO:0030425 (dendrite), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)