Protein: DNA topoisomerase 2-binding protein 1 isoform X2 (A0A8M6YVL2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
- IPR044737: TopBP1, first BRCT domain (domain) [109-180]
- IPR036420: BRCT domain superfamily (homologous_superfamily) [1-1490]
- IPR049542: TopBP1-like, BRCT0 domain (domain) [9-105]
- IPR049936: TopBP1, eighth BRCT domain (domain) [1395-1475]
- IPR059215: DNA topoisomerase 2-binding protein 1-like, second BRCT domain (domain) [198-274]
- IPR001357: BRCT domain (domain) [104-1485]
Sequence:
MSKASKDAYIVKFVESNGQKSDVALQAYKAIVELQSEKYVQMVDEEAALELDHNDKSLFVFSDFTSSAFDHCRRLGCRIVSPLVVLFCLQKQRCVPKAEQPVYNMSMADVTVSCTNLDKEARSEVMDLIQLMGGRVYRDLNVSVTHLVAGEVGSKKYLVAASLGKPILLPSWVKACWEKSQDSVFHHSELNTEDYRCPVLKGCTVCVTGLSTVERKEVQRLCDQNGATYTGQLKMNECTHLIVNEPTGQKYEFARKWNVYCVSLHWLFDSIEKGFCQDESRYAVERGDKRKTDDKSGRPNTSTPTGQSRSKEDGPSLLGLSHISNISLNVNETALTTAGISHIEMPDPVDSFDITVCRVDDLLDGCKLYLCGLSGKKLEKLRRMVNTAGGLRFNQPTQELTHIVMGEADQGIKAFLDNATHRPHIVTVQWLLESFSRGSLLPENGYFHPSFLPPAPAAVDIPALHKAAPRASRPSVAPPPAPSPARQSRAEEDLLSQYMGNDQTVELPQDTSSRHSVLHPEPLVEGKDSTLAEASEGGLFFGKRFILVGFGAEAEAQLSELVMENAGKILVGRSRAVAHYAIVPLLGCDVEATVDEVATDTWLAMCVEQQCVLPLASHPLFTPVAVREGFSPLKDCVLSVSQFTGAERDSLIQLAKHLGASVQDYFVRTANQRKGMLASTHLVLQTPEGTKYQAAQKWGLPAVTIRWVLESARTGKRADEGQYLVDLPPSPERTEDSFVGASQKDPPPLRLHQRSPELPLLGPQNSDAITPLDTARFQSRSVRSAVRKLKQGEEEQAEVTTPGQEEAKGAQQKDSSLHLDTPSRFLSRDKLFGPSFNTKDVFDHLQTPGNKSQQGQGAETPLSEVIERNLKAAVANSNRSHVTNLAAMTASPQLGKEPEPEVEQKAAAPLSGVVVCVSKKLSKKQSELNAVAASLGAEFRWSCDDSVTHYIYQGKVGDNSKEYRAVKERGLYIVSQHWLQACADEQKHVSESLYPFTFNPKMSLTMSQMADSTQRSPPSATPRTRLRAFAENEETRLGPDDDITDVSTPKQGSVGEPEKDQTISTEKKNLTETLEMRESLQRQLQEIMSATKLTSGRRGSSRLAKTGPGGLDSPHTPDSLGRMSRRSRNLEAIRMSRQVCVDLNTEPSQSEQIVWDDPTAREERAKLADNLQWPGSPSQHSEPLALVPPPHSDHTTNGRDSMTDSELVEMAAFEVIDAQLKPKGTSSRVDTLHNPKTPEAPSIAFPISKTAALPLPRIEDEEEELKKDPPRFLLSSLNPQERIDYSHLIEELGGVVLEKQSFDPSCTHVIVGHPLRNEKYLAAMAAGKWILHRSYLEACRAEGHFIQEDQYEWGSSSILEALPSINSQQKRLALAAMRWRKTLQGCSNKEGAFGGWIVMLNIDQAREAGFRRLLQSGGAKVLPDPSPSLFKETTHLFVDFSRLKPGDVRVDISEASAHGVKCLKPEYIADYLMQEPSPSMDAYYLPGAAADETEKVVDASSRKRKASGDMSTLKKSRMR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0010941 (regulation of cell death), GO:0048468 (cell development), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0033554 (cellular response to stress), GO:0080134 (regulation of response to stress), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0030097 (hemopoiesis), GO:0006974 (cellular response to DNA damage stimulus), GO:0043067 (regulation of programmed cell death), GO:2001233 (regulation of apoptotic signaling pathway), GO:2001020 (regulation of response to DNA damage stimulus), GO:1902531 (regulation of intracellular signal transduction), GO:2001242 (regulation of intrinsic apoptotic signaling pathway), GO:0060216 (definitive hemopoiesis), GO:0042981 (regulation of apoptotic process), GO:1901796 (regulation of signal transduction by p53 class mediator), GO:1902229 (regulation of intrinsic apoptotic signaling pathway in response to DNA damage), GO:1902253 (regulation of intrinsic apoptotic signaling pathway by p53 class mediator), GO:1902165 (regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)