Protein: ribose-phosphate diphosphokinase (A6HB94)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis
InterPro domains:
- IPR029099: Ribose-phosphate pyrophosphokinase, N-terminal domain (domain) [4-120]
- IPR005946: Ribose-phosphate pyrophosphokinase (family) [1-316]
- IPR000836: Phosphoribosyltransferase domain (domain) [147-274]
- IPR029057: Phosphoribosyltransferase-like (homologous_superfamily) [6-306]
- IPR000842: Phosphoribosyl pyrophosphate synthetase, conserved site (conserved_site) [128-143]
- IPR037515: Ribose-phosphate pyrophosphokinase, bacterial-type (family) [4-314]
Sequence:
MPNIKIFSGSSHQDLSQKITERLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDSLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPMSAKLIANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENISDWRNCTIVSPDAGGAKRVTSIADHLNVDFALIHKERKKANEVDRMVLVGDVKERVAILVDDMADTCGTICYAADKLLSEGATRVYAILTHGIFSGPAIARINGACFEAVVVTNTIPQEDKMKQCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0030246 (carbohydrate binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0016740 (transferase activity), GO:0043167 (ion binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0043169 (cation binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0016208 (AMP binding), GO:0043531 (ADP binding), GO:0017076 (purine nucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0016778 (diphosphotransferase activity), GO:0019003 (GDP binding), GO:0032555 (purine ribonucleotide binding), GO:0046872 (metal ion binding), GO:0005524 (ATP binding), GO:0019001 (guanyl nucleotide binding), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding), GO:0000287 (magnesium ion binding), GO:0032561 (guanyl ribonucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0003006 (developmental process involved in reproduction), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0007548 (sex differentiation), GO:0046661 (male sex differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0008406 (gonad development), GO:0046546 (development of primary male sexual characteristics), GO:0061458 (reproductive system development), GO:0008584 (male gonad development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:1990234 (transferase complex), GO:0061695 (transferase complex, transferring phosphorus-containing groups)