Protein: Lamin A/C (A0A6Q8PFJ0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus lamina
InterPro domains:
- IPR036415: Lamin tail domain superfamily (homologous_superfamily) [401-550]
- IPR001322: Lamin tail domain (domain) [428-545]
- IPR039008: Intermediate filament, rod domain (domain) [30-387]
- IPR018039: Intermediate filament protein, conserved site (conserved_site) [373-381]
Sequence:
METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQVSCLCFVSKSCRRVPGHRGVGRGGLAGGRACLLFRSPGEWEPPPHSLSPRQPTSASCPSCLSPRLEGRGRAGV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0050794 (regulation of cellular process), GO:0007049 (cell cycle), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0051640 (organelle localization), GO:0033036 (macromolecule localization), GO:0001666 (response to hypoxia), GO:0061061 (muscle structure development), GO:0042127 (regulation of cell population proliferation), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0008285 (negative regulation of cell population proliferation), GO:0070482 (response to oxygen levels), GO:0048513 (animal organ development), GO:0050000 (chromosome localization), GO:0090398 (cellular senescence), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0097240 (chromosome attachment to the nuclear envelope), GO:0070727 (cellular macromolecule localization), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0071456 (cellular response to hypoxia), GO:0071453 (cellular response to oxygen levels), GO:0051052 (regulation of DNA metabolic process), GO:0010256 (endomembrane system organization), GO:0036293 (response to decreased oxygen levels), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0033043 (regulation of organelle organization), GO:0008104 (protein localization), GO:0007517 (muscle organ development), GO:0006996 (organelle organization), GO:0061024 (membrane organization), GO:0006997 (nucleus organization), GO:0036294 (cellular response to decreased oxygen levels), GO:0032204 (regulation of telomere maintenance), GO:0006998 (nuclear envelope organization), GO:0033044 (regulation of chromosome organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005654 (nucleoplasm), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0043229 (intracellular organelle), GO:0016607 (nuclear speck), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)