lokahq/bioreason-rl huggingface dataset:
Protein: ubiquitinyl hydrolase 1 (A0A8M2B4S2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR002653: Zinc finger, A20-type (domain) [876-911]
- IPR051346: OTU Domain-Containing Deubiquitinase (family) [82-683]
- IPR003323: OTU domain (domain) [176-356]
Sequence:
MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDLSAALSDFEQLRQVHAGSLSCSFVEESEYPSIEKEMARTGRPLLHRQDEAVQATEKRLSRGISHASSTIVSLARSHVSSTGGTNEQLLDTPLCTFQLPDLTVYRDDFRGFIERDLIEQSMMVALEQAGRLNWWTRLGTGCQSLLPLATSGDGNCLLHAASLGMWGFHDRDLMLRKSLYALMDHGQEREALKRRWRWQQTMQNKESGLVYTEEEWQKEWNELLKLASSEPRIHYSTNGSSGAESQEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPANKCHRSPLVLAYDQAHFSALVSMEQKDSSKEQVVIPLTDSDHKMLPLHFAVDPGADWEWGKDDNDNVMLASVTLSLEAKLHLLHCYMTVTWLPLPCEVQQAPLAQPESPTASAGEDARTPPDSGESDKESVSSSSNGNGDSSTTGTSGTTGKTSGGSSSSSSSSSNSSGGTTGTIGKEKGKKDKEKDKDKDKKRADSVANKLGSFGKSLGSKLKKNVGGLMPGKNASGTGGKQEGQEKKKGSLRGRKGSKDSSPSIQTGSEDSGKGSPSSTSERQNGGYSSESDPFKYSSDVKVSLSILRSAMQGERKYIFSALLTTSNRQPFQEEMIQRYLVDAEERFHAEQEQRREAERKAAGGLASTTGPQMKKDGPELSYRGFESKEEVTDSSPPNFNALKSSSFSPVMYSGVVPIPRHTFIDHSPSPMTQHLHMHHGYMDTRRQLAGGSPSSYPGLPSYATLPRHCPLAQGPPHAQYHPPSASLGSPSRIITPCLTSFPQEHDPTDYPSEPSGAYTNGLRDLRSTLDSRNGPMPVRHYSLGSAGGLANLQSSKCRTPTCNYYGHPETGNYCSYCYREELKRRETEPAIHRF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:0004843 (cysteine-type deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway), GO:0007219 (Notch signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Synembryn (A0A8M3AY41)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP
Subcellular location: Cytoplasm
InterPro domains:
- IPR019318: Guanine nucleotide exchange factor, Ric8 (family) [5-719]
- IPR008376: Chaperone Ric-8 A/B (domain) [517-675]
- IPR016024: Armadillo-type fold (homologous_superfamily) [291-592]
Sequence:
MTVDVEKIIQFIKQGDQDNVQSHLDDYNTENSQCFFFDVEERERKKFILISSHLFSGYIIQACFLSCYFSFLIILQCLNREQQRELEEFRRNKVREYVPDSDSDCDSDNSEDPDLVLRRRLAAALIWFIRMRLQPGVLRVCLRTLRIISRDRKALAPLITDYAIITLARLGGISALPTWPEEEDDQWGSSHNDVAPENETDTLPDNDTNTQCPACCSETDDSCCGSTVCAASSVREGGLHFSPMNNTSNPRETQNDHCEESVRKDGVCGLLTRGKRETRGERDEEGEEGHDDGEIWRKEAMKTLCNVIYNSPKAQERASTLRLLHGLSVRIKDGIHSSSPPSGQFYELRLLFLLTALRPELRIELCQERGVSMLTAALEQCLDVIWGETHEVLTDLTAPPLCKELSQRALEILKTLFNITYSVHRQDLDEEAAALYRRLAAVLRHCLLVPCEGEDRKEELQGHTVNVLSALPLQCLDVLLSVRLSEGSEESGGVNMDCVHTLLLFMEKRLDRGHKLKEKLTPVLNLLTESSKAHRETRHYLRQQILPPLRDVELRPEQGNTLRSRLVRLMTHVDTDIKHCAAELLFVLCKENVSRFVKYTGYGNAAGLLAARGLLNGRGSSPQPQYSSDSDSDTEEYRQARDRINPVTGRVEEEQPDPMEGMTEEEKEAEALRLINMFNRLSRGKIIQPMGVTTDGKLAPLCGQTRHSAVQEEEEEDEEDDDCSETEQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0001965 (G-protein alpha-subunit binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0048869 (cellular developmental process), GO:0048066 (developmental pigmentation), GO:0048856 (anatomical structure development), GO:0030154 (cell differentiation), GO:0050931 (pigment cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: calcium/calmodulin-dependent protein kinase (A0A8M9PKC4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [131-143]
- IPR000719: Protein kinase domain (domain) [13-271]
- IPR013543: Calcium/calmodulin-dependent protein kinase II, association-domain (domain) [400-527]
- IPR017441: Protein kinase, ATP binding site (binding_site) [19-42]
- IPR032710: NTF2-like domain superfamily (homologous_superfamily) [394-524]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [9-286]
Sequence:
MATTTCTRFTDEYQLYEELGKGAFSVVRRCVKLSTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLLFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKNAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAQEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLVSRNFSVGSRQTTAPASVTAAAAAVAAAAGTTAGLVEQAAKTLLNKKADVKPQTNSTKNSIVTSPKGNLPSPALESSDSSNATVEDEEMKARKQEIIKITEQLIEAINNGDFEAYAKICDPGLTCFEPEALGNLVEGMDFHRFYFENLLSKNSKPIHTTILNPHVHLIGEEAACIAYIRLTQYVDGQGRPRSSQSEETRVWHRRDSKWQNVHFHCSGAPAAPLQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009628 (response to abiotic stimulus), GO:0070482 (response to oxygen levels), GO:0001666 (response to hypoxia), GO:0036293 (response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: RNA binding motif protein 14 isoform X1 (A0A8M9Q1B8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR036875: Zinc finger, CCHC-type superfamily (homologous_superfamily) [154-190]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [6-153]
- IPR003954: RNA recognition motif domain, eukaryotic-type (domain) [8-149]
- IPR001878: Zinc finger, CCHC-type (domain) [166-180]
- IPR034506: RBM14, RNA recognition motif 1 (domain) [7-75]
- IPR000504: RNA recognition motif domain (domain) [7-153]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [6-158]
- IPR051945: RRM MRD1 RNA Processing and Ribosome Biogenesis (family) [77-170]
Sequence:
MDKGHTVKLFVGNLALDTTQEELSAIFESYGQVVSCSVLRQFAFVHLQGEGAAERAIRELNGREFKGRNLVVEESRGRPLHSTKVFVGNLSSMCTTEDLQELFQTFGKVLECDKVKGYAFVHMENKEDALQAIEALHGTSFKGRPLSVELSKVQPSKQTPTGKIPCVSCGKQGHYAGECPAGKPTLEQYQSQAAVLAAAAAAAAGLPLQVQQSVHNSVYNTSTFDPTYAALTGLTAAGARAEGGAAVAPAVYGALASQVYGTAVANQLYGGSVANQALNSSAAAAAAQAYGSVNPALYGQMTSGAVAAAAAAAAAYGPQVGFLVYTQAVGNPVFLTAAPSMEVPAGAAAVNPAYTVAPALYSATPAYGALGAADPAAIFEAARAHYFAQGQQVLAEQQQASSKSGERDRSPLRRSAPLLPDPVMKPFIYQRAKRRALLPTPAGREEAAAQEDDPVARYYAEYYQQYQQLQQYPQYQYAYPAHSALAAMSALQSLPGVSAQQVATLDSLRPVLPAAPVPAAAAIAMATPRVYEPPPIPPSHKEPLLRRPELALHTPETPFR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0071495 (cellular response to endogenous stimulus), GO:0007166 (cell surface receptor signaling pathway), GO:0070848 (response to growth factor), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0071772 (response to BMP), GO:0071363 (cellular response to growth factor stimulus), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0071773 (cellular response to BMP stimulus), GO:0030509 (BMP signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Prominin-1 isoform X3 (A0A8M9QPM2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, microvillus membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
Sequence:
MDMWWKVGLVLVMFWGLTSSEDREEHRESPPRTAMLRAPVETLDFGFVPSVVYETHAYYEPGPMGILFHMVHAFLYVVQPNPFPKDLIVKMVQQNMGGIKGDDYKKPENVVLLLQTIYYELGFIVLSVLGVFFVLLMPIVGLCFCVCRCCENCGGEMHQRQKKNGDCLRGFYMATLIATSVFLAVGVTVAYVANQNITSQIKSTRRLVSTNIRDLKAFANYTPAQIDYLTAQYTTAKNKVLSDLDNIGTLLGGQIHNKLESEVVPALDHALRMTAVKVESAIKAMRETKESLESVSTSLETLQEGTGRLQVSLQSERVSLSNTLNDWACSNEDVTHTCNSIRGTLNQLALSANFNGLPDVEAPLANLDAVLKTDLSNIVQKGYSSFNDTPQLVREQTKGIVSALPKVKGLLDKSGAEIIGFTKMFPVEPALQNFSKFLTDSQKNIEAYYPQIDQLDFYRWIGCVLICCLVVLVLAFNFLGLLCGSCGYDKNSTPTTRGCLSNTGGNLLMASVGFSFIFSWVLMGVVVTTFIVGGNIEKLVCEPLANRQIFKIIDTPYMVHPTKKNFLPGMLFQDPNIDLTIGSMYRDCYENNGLYSALQLETKFNFNKFLNATVFNPEIGDIFNNVNVDLQGMLLLEQEGKDNLIDFANTGIGDIDYQAYLTEVNKGVTVVDLLSYANELDAQADNLPRGALENALKGHASSIRQIHKDQVVPMEQAMSNLNQSIRQLEKTSRELPVKVTNVLNAIEAAEYLISNNASHVVKQESDKFIKKIIGYFSQYTEWVKHSLAMEVAQCKPISNIVDSAEIVACSFIVDSVNTFWFGLGGCCVLLIPSIIMSVKLAKFYRRMDTEDVFDDYPSYDTMRWYPRASAPPRQPDW
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0007283 (spermatogenesis), GO:0048515 (spermatid differentiation), GO:0007286 (spermatid development), GO:0048232 (male gamete generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045177 (apical part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane)
Protein: Hairy and enhancer of split related-7 isoform X1 (A0A8M9PKJ6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
Sequence:
MNTIETCTCCNINQLKRDLLTDISPLRFLKLLKPQVERRRRERMNRSLENLKLLLLQGPEHNQPNQRRLEKAEILEYTVLFLQKANKASKEEEGEEKSQFMEGFSSCLQKAARFLLEEGGLEGSVTSMLCQRLAHPTIRLPVRGHSRKQHAESNPQHHARRPHHKNTVSKAGHPSACRNTKEPQASRAAFRSTDSNTKHSTAQPTSRHPEPASQTVWRPWP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001756 (somitogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0007379 (segment specification), GO:0009790 (embryo development), GO:0009880 (embryonic pattern specification), GO:0035282 (segmentation), GO:0001757 (somite specification), GO:0061053 (somite development), GO:0060429 (epithelium development), GO:0009952 (anterior/posterior pattern specification), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Tyrosine-protein phosphatase auxilin isoform X4 (A0A8M9QB30)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [122-281]
- IPR001623: DnaJ domain (domain) [889-954]
- IPR029023: Tensin-type phosphatase domain (domain) [114-281]
- IPR014020: Tensin phosphatase, C2 domain (domain) [285-422]
- IPR036869: Chaperone J-domain superfamily (homologous_superfamily) [777-954]
- IPR035892: C2 domain superfamily (homologous_superfamily) [286-419]
Sequence:
MSLLGGYKKKSSYDGYESLQLVDSSGDFSTGGRSGGGGGGGLTAVTLGSVKTGPARQDDYSTMDSSGPPSPDMDGNYGGGLLDMVKGGAGKFFSNIKDNLKDTIKDTSTKVMNQVATYTKGELDIAYITSRIIVMSYPAETVEMGYRNHTEDIRSFLDSRHADHYTVFNLSQRNYRGAKFSNRVSECNWPSRQAPSLHNLFAVCKNMYNWLKQNPKNVCVITCSDGRAPSGVLVCAMFCFCHLFANPVPAMQLLSAKRPGSGLWPSHRRYIGYVCSLVSEKPTVPHSKPLVIKTVTISPVPCFNKQRSGCRPFCDVLIGETKIFSTAQEYERMREHRIQEGKVVFPVGVSAQGDVVISVYHMRSHALQAKVTNTQIFQIQFHTGFIAPGSTVLKFMKTELDACDSPEKYPQLFHVLIDIEVESTEKQKDLTPPWEQFPTKDLSPNVLFSCHQEHQDALAIADEMEGLDLEDPAQGHSSCGGRVGPNEESEPSDDEMLSLSSQQSNASNEKSKAAKRPEPQAAAPPPPAAEEVDLLGLDGDAAKIPPSSPQPPANNTTTDLLGDLFGAPPTPQPASCPGSAQSTPRRSAQSSSPGPSPRSGNTFDPFGSGPAPAPKPQDFMGAFLGPGRSSPVPPSTPTVNIQQQNSTGAWEWNKPAAAGGGFGMGSKSASTSPTSSAHGTPTHQTKPNTLDPFADLGNLGAGLGGGGSGFSSKPTTPTGTGGAFPPMGSPQRPAPSPQHTASGGWHPNTGFPSWQAGGGAQWQPQAQGTPTKAPPASMPHTSPQNRPNYNVSFSAMSGASPGAAGPKAQPNMGTRPKVSDANFDDLLSGQGFAGGKEKKGPKTIAEMRKEEMAKEMDPEKLKILDWIEGKERNIRALLSTMHTVLWEGETRWKPVGMADLVTPEQVKKVYRKAVLVVHPDKATGQPYEQYAKMIFMELNDAWSEFESQGQKALY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0005515 (protein binding), GO:0030276 (clathrin binding), GO:0019904 (protein domain specific binding), GO:0032050 (clathrin heavy chain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0003008 (system process), GO:0007610 (behavior), GO:0050877 (nervous system process), GO:0010941 (regulation of cell death), GO:0007611 (learning or memory), GO:0007613 (memory), GO:0050890 (cognition), GO:0043067 (regulation of programmed cell death), GO:0042981 (regulation of apoptotic process), GO:0007616 (long-term memory)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm)
Protein: Phosphatidylinositol glycan anchor biosynthesis class U protein isoform X1 (A0A8M6YYR1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR009600: GPI transamidase subunit PIG-U (family) [1-361]
Sequence:
MIYLFHFLVDYAEIVFMIADGITAVALYLSVQIYNKNVFRKQKYALESERYPADCLELLRSPKEMFYIPLKVAMFYLLNPFTILSCVAKSTCGLNNAIIALFILCTLKGSALLSGILLALATYQSMYPLTLFAPALLFFLQRLYIPVNLRRSSFWFFTLQYAFIYFGSLVVITGLSFFLLGSWDFIPSVYGFILSVPDLTPNIGLFWYFFAEMFEHFRLFFICVFQINVFFYTIPLSIKLKEHPVFLMFMQIAIISIFKSYPTVGDVALYMAFLPAWSHLYRFLRNIFLVSCVLLACSALFPVLWHLWIYAGSANSNFYYAITLLFNFGQILLVSDYFYAYLRREHHLTHGLYLKKKDGTEATLVLK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0009628 (response to abiotic stimulus), GO:0051606 (detection of stimulus), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0009581 (detection of external stimulus), GO:0070727 (cellular macromolecule localization), GO:0009582 (detection of abiotic stimulus), GO:0050877 (nervous system process), GO:0009612 (response to mechanical stimulus), GO:0050906 (detection of stimulus involved in sensory perception), GO:0050974 (detection of mechanical stimulus involved in sensory perception), GO:0008104 (protein localization), GO:0050982 (detection of mechanical stimulus), GO:0007600 (sensory perception), GO:0034394 (protein localization to cell surface), GO:0050954 (sensory perception of mechanical stimulus), GO:0050976 (detection of mechanical stimulus involved in sensory perception of touch), GO:0050975 (sensory perception of touch)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)
Protein: Toll-like receptor 4 (A0A8M3B7X7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, ruffle. Early endosome. Endosome. Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR017241: Toll-like receptor (family) [17-821]
- IPR035897: Toll/interleukin-1 receptor homology (TIR) domain superfamily (homologous_superfamily) [669-820]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [74-564]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [21-608]
- IPR000157: Toll/interleukin-1 receptor homology (TIR) domain (domain) [676-822]
- IPR001611: Leucine-rich repeat (repeat) [76-382]
- IPR026906: BspA-type LRR region (repeat) [399-517]
Sequence:
MAALKMGFYAISVFLICYYIANGEPCTRIIENLHYSCMGRNLSSIPSSIPSSVQTLDFSFNFFPQLKKTIFPVLSFLRVLDLSRCHIRQIENDAFYNVKNLTTLFLTGNPIIYFAPGCLNTLYNLQRLVLVDIGLESLQLNINNLTKLQELNVGTNYIQSMTLPPFMTTFKNFSLLDLHANNISIIRTNHTVVLREIGRNMTLILTWNPLLHIEPGAFKDVYLRQLDIRSAFVSFSAQKAALKALHGLNVKRLIFGKYREDNGFHFVDNDVLDGLCCFNFQEVSYYVLESAKTTIAIFRCMINATRITVKGGNIYEMETVHFHKTKELYLINNGLGTLPTKQLSHLHTLEKLEITHNSEPIFAEPFTDLPKLQYVDLSDNQLKIKHCCSTLLSGTPQINYLNLSLNSEISVDVGGFEGLDSLEILDFSYTRVVRIGYLSVLSNLKNLRYLDVSYSSVTFSNIFCFLGLSSLNVLKMAGNNFQGNVAKYVFNNLTLLEHLDMSFCHLVELHTSSFKYLQRLRHLNVKGNYLIKIDFLTHPNLKQLTSFYVEKNSITAIPLHVLKNLPMNLSEFDLSFNPIDCSCSQTDFMLWIINNQKVLKQPENILCKTISPNSDFRVTDFDIDHCVYKKKLIIVLPVFCVVFIVVLSILVYRFQFYLRYCWILLRGYRSPGQQECSYDAFVIFSSYDEAWVMNELMENLENGVPPIQLCLHMRDFQAGKSIASNIIDEGIMGSRKIIVVVSQHFIDSAWCRFEFELAQSRFLMERNANIIIIILEDVAERKTKKILGLHKHLKKNTYLKWSRDPLSNMRFWIRLRKAIVATKQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0050793 (regulation of developmental process), GO:0051094 (positive regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0045595 (regulation of cell differentiation), GO:1901532 (regulation of hematopoietic progenitor cell differentiation), GO:1901534 (positive regulation of hematopoietic progenitor cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)
Protein: Nucleosome assembly protein 1-like 1 isoform X2 (A0A8M2BJ06)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR037231: NAP-like superfamily (homologous_superfamily) [52-351]
- IPR002164: Nucleosome assembly protein (NAP) (family) [61-355]
Sequence:
MADLDNKDQAEMDPADMEDVEEEEEDAGEDNSKARQLTRQMMQNPQILAALQERLDGLVGSPSGYMESLPKVVKRRVNALKNLQVKCAHIEAKFYEEVHELERKYAALYQPLFDKRSEIVRAAYEPTDEECEWKQDEEEELTEEMKEKAKVEEEKKDEEKEDPKGIPEFWLTVFKNVDLLSEMLQEHDEPILKHLQDIKVKFSDAGQPMSFTLEFHFEPNDFFTQTILTKTYKMRSEPDESDPFSFDGPEIMGCTGCTIDWTKGKNVTLKTIKKKQKHKGRGTVRTVTKTVPNDSFFNFFSPPEVPESGELDEDSEAVLAADFEIGHFIRERIVPRAVLYFTGEAIEDDDDDYDEEGEEADDEEGEEEADEENDPDYEPKKDANPPEECKQQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042393 (histone binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0009620 (response to fungus), GO:0043207 (response to external biotic stimulus), GO:0001878 (response to yeast)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)