Protein: PALM2-AKAP2 fusion protein (O54931)
Organism: Mus musculus (Mouse)
Function: Binds to regulatory subunit (RII) of protein kinase A . May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. Binds tp and modulates the structure of the actin cytoskeleton
Subcellular location: Apical cell membrane ; Lipid-anchor, GPI-like-anchor ; Cytoplasmic side . Note=Accumulates near the inner, apical surface of highly polarized epithelium in tubules of nephrons
InterPro domains:
- IPR004965: Paralemmin (family) [15-133]
Sequence:
MEIGVSVAECKSVPGVTSTPHSKDHSSPFYSPSHNGLLADHHESLDNDVAREIQYLDEVLEANCCDSSVDGTYNGISSPEPGAAILVSSLGSPAHSVTEAEPTEKASGRQVPPHIELSRIPSDRMAEGERANGHSTDQPQDLLGNSLQAPASPSSSTSSHCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEEDEREKEQFCVRKVRPSEEMIELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEEQLDEEHLESHRRYKERKEKRAQQEQLQLQQQQQQQLQQQQLQQQQLQQQQLQQQLQQQQLSTSQPCTAPAAHKHLDGIEHTKEDVVTEQIDFSAARKQFQLMENSRQTLAKGQSTPRLFSIKPYYKPLGSIHSDKPPTILRPATVGGTLEDGGTQAAKEQKAPCVSESQSAGAGPANAATQGKEGPYSEPSKRGPLSKLWAEDGEFTSARAVLTVVKDEDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETTSALQENSLADFSLPQTPQTDNPSEGREGVSKSFSDHGFYSPSSTLGDSPSVDDPLEYQAGLLVQNAIQQAIAEQVDKAEAHTSKEGSEQQEPEATVEEAGSQTPGSEKPQGMFAPPQVSSPVQEKRDILPKNLPAEDRALREKGPSQPPTAAQPSGPVNMEETRPEGGYFSKYSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVRQSTPSPRAKNAPSLPSRTTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAPEEAAGTQRPKNLMQTLMEDYETHKSKRRERMDDSSYTSKLLSCKVTSEVLEATRVNRRKSASGLALGGRDLR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0051018 (protein kinase A binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0033036 (macromolecule localization), GO:0050794 (regulation of cellular process), GO:0070727 (cellular macromolecule localization), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0008104 (protein localization), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0007015 (actin filament organization), GO:0007010 (cytoskeleton organization), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0005829 (cytosol), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0043197 (dendritic spine), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0043228 (non-membrane-bounded organelle), GO:0043005 (neuron projection), GO:0098984 (neuron to neuron synapse), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0014069 (postsynaptic density), GO:0030425 (dendrite), GO:0005856 (cytoskeleton), GO:0032279 (asymmetric synapse), GO:0044309 (neuron spine), GO:0015629 (actin cytoskeleton)