Protein: Guanylate cyclase (A0A8M3APR2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Photoreceptor outer segment membrane; Single-pass type I membrane protein
InterPro domains:
- IPR050401: Cyclic nucleotide synthase (family) [144-1069]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [575-809]
- IPR029787: Nucleotide cyclase (homologous_superfamily) [872-1069]
- IPR000719: Protein kinase domain (domain) [541-812]
- IPR011645: Haem NO binding associated (domain) [825-870]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [57-459]
- IPR001054: Adenylyl cyclase class-3/4/guanylyl cyclase (domain) [849-1062]
- IPR001828: Receptor, ligand binding region (domain) [78-416]
- IPR018297: Adenylyl cyclase class-4/guanylyl cyclase, conserved site (conserved_site) [992-1015]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [569-852]
Sequence:
MRHIHLPFGGALWQFSSYPCCPVLRSRRSLSTLPFYSITLWIILGVLTFPRCVQCLVFKVGIIGPWNCDPNYAKSLPAIASRLAVGRINNDFSLDLGCTMDFVILQEACETSKALTSFVQYENVADAFVGPTNPGYCNAAALMSKNWDKSLFSWACVNHELDRVQGYPTFARTLPSPLRVLFNVLKFFRWANIGIVSSNEDIWIDTAAKLASALRNRGLPVGIVTSMGNNDTMLENTLMSIKNAGDIKVIIMCMHSVLIGGEQQATFLTKAYDMGLASGRYVFIPYDTLLYSLPYINITYYPLQNNSKLSKAYDAVLTITLDSDIMTFNEAFNAAKQLGELMVTQEPEQVSPLFGTIYNSLYLLAKSMHNARRAGRWLSGTNLAYFTRNITFTGFNQDIQTDEQGNGQTNYVILDTEAWGTQLYRCFLVDMTSDLVLFAGRFIHFPGESPPPSDSRCWFEDNAICTGGVDIIYVIIAFVIVLIIVLGSIGLSLFIRRRIQQIQLIKGPNRILLTLEDLTFINPQLSKRKITLEDLSDSKSYIEEKSTGDRSRSVNSMATATHETSNVAVYEGDWVWLKKFTEGHFKEVKQSTTKIFTKMKDLRNENVNPFLGFFTDCEMFAIVTEHCSRGSLHDLLRNDDVKLDWMFKSSLVLDLIKGMKYLHHREFPHGRLKSRNCVVDGRFVLKITDYGYNEILETQKAPKETLPPEDLFWTAPEHLRDPESPRKGTYKGDVYSFAIILQEVVVRGAPYCMLGLSPEEIIRKVKKPPPMCRPTVAPDQAPLECIQLMKQCWSEQPDRRPPFDQIFDQFKLINKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEVEKQRTEKLLSEMLPPSVAEALKTGASVEPEYFDQVTIYFSDIVGFTTISSLSDPIEVVDLLNDLYSLFDAVLGSHDVYKVETIGDAYMVASGLPKKNGNKHAAEIANMSLNILSSVGSFKMRHMPEVPVRIRIGIHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNISTVQILRSLNDGYKIDVRGKTELKGKGIEETYWLVGKANFTKPLPNPPEIKPGEDNHGLKPEDIEAYKRRKAEKKR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0009975 (cyclase activity), GO:0004383 (guanylate cyclase activity), GO:0016849 (phosphorus-oxygen lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0003008 (system process), GO:0016043 (cellular component organization), GO:0050877 (nervous system process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0035845 (photoreceptor cell outer segment organization), GO:0007399 (nervous system development), GO:0030182 (neuron differentiation), GO:0007600 (sensory perception), GO:0048666 (neuron development), GO:0042461 (photoreceptor cell development), GO:0046530 (photoreceptor cell differentiation), GO:0050953 (sensory perception of light stimulus), GO:0048699 (generation of neurons), GO:0007601 (visual perception)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0043226 (organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0043227 (membrane-bounded organelle), GO:0005929 (cilium)