Protein: D-amino-acid oxidase 2 (A0A095C6S0)
Organism: Cryptococcus gattii serotype B (strain R265) (Filobasidiella gattii)
Function: Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity. Enables the organism to utilize D-amino acids as a source of nutrients. Enables the organism to utilize D-alanine, D-cysteine, D-histidine, D- leucine, D-methionine, D-phenylalanine, D-proline, D-serine, D- threonine, D-aspartate and D-valine as a nitrogen source and may also contribute to utlization of D-tryptophan, D-tyrosine and D-asparagine as a nitrogen source. Protects the organism from the toxicity of D-amino acids, including from D-alanine. May play a role in its interaction with the host
Subcellular location: Peroxisome matrix
InterPro domains:
- IPR023209: D-amino-acid oxidase (family) [4-387]
- IPR006076: FAD dependent oxidoreductase (domain) [4-378]
- IPR006181: D-amino acid oxidase, conserved site (conserved_site) [354-372]
Sequence:
MSFDAVVIGSGVIGLSIARELDNRGLKVAMVARDLAEDSLSVGFASPWAGCNWYSFAEGGTPAAEWDAITFSKLAKLAEDHPDLCEKIPFCSVWDLPKSDSESEPWFKDLVFEYKKLKSTPGQHLAGGKKFGYSFKSYVLHAPNYIRHLSSEIRARGIPIHRYRLSSIDEAYNLPGIGKVSLVVNASGLGAKSLIGVEDEKVYSGRGQTVLVRAPGFKACIMHTEGFYADLDESGREITPPPPAYIIPRPGPEGHVVLGGVYQKDNWSTLPDLKEAERILKDCYNLAPELAGPNGKSWKDIEIISHNVGLRPAREGEPRLEIEEREVGTGANGGNGYEVAPKFGCEGERRKVAVVHAYGIGSAGFQASLGMAEKASDLVEKYLSGRRTSAKL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0016491 (oxidoreductase activity), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0016638 (oxidoreductase activity, acting on the CH-NH2 group of donors), GO:1901265 (nucleoside phosphate binding), GO:0016641 (oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor), GO:0050660 (flavin adenine dinucleotide binding), GO:0071949 (FAD binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0016054 (organic acid catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0009063 (amino acid catabolic process), GO:0009068 (aspartate family amino acid catabolic process), GO:0019752 (carboxylic acid metabolic process), GO:1901606 (alpha-amino acid catabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0009066 (aspartate family amino acid metabolic process), GO:0006553 (lysine metabolic process), GO:0006554 (lysine catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)