Protein: Guanylate cyclase (A0A8M3AQN2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single- pass type I membrane protein
InterPro domains:
- IPR050401: Cyclic nucleotide synthase (family) [142-1064]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [570-809]
- IPR029787: Nucleotide cyclase (homologous_superfamily) [872-1068]
- IPR000719: Protein kinase domain (domain) [539-812]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [46-467]
- IPR001054: Adenylyl cyclase class-3/4/guanylyl cyclase (domain) [851-1063]
- IPR001170: Adenylyl cyclase class-4/guanylyl cyclase (family) [127-506]
- IPR001828: Receptor, ligand binding region (domain) [68-423]
- IPR018297: Adenylyl cyclase class-4/guanylyl cyclase, conserved site (conserved_site) [994-1017]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [566-853]
Sequence:
MSLLLCFSESRFFLLPLLLLCCGTLSTWTKISKHQGSHKGAHNHSNDIVLAVILPQHNTSYPWAWPRVGPALDRAIARVNANPNLLPRHRVRHVFANSEDRDGICSESMAPLMAVDLKFEHNPWAFIGPGCDYTSSPVGLFTAHWGLPMITAGAPAVAFLQMEIYTSITNTGPTHKKLGEYALHLYRHFGWNQHSLLMFSDTKMGERACYFALEGLYTEMHEENITTMDLVFEENKGPVNYSELLHKIQGDGRVVFVCCSPDVFRQLIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPWARGDSDDVFAKEAFQSVKILTYLEPQNQEYKDFVTDLKSDAKRMFNFTVDDSLMNIISGGFYDGLMLYCHALNESLSDSHERPSGESVSKRMWNRTYYGVTGLVQIDENGDRETDFALWDMADINTGDFQIVAVYNGTQKEMNILPGMAIQWPGGKVPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDIQMSHLEKALRSTGSKLTLSLRGSNYGSLLTTDGNFQVFAKTGYFKGNIVAIKYINRRRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIRTESDTEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEGDLLSPKEIVDRVALGEWPYLRPSLNPQAHSEELGQLMQRCWAEEPSDRPEFSHISVLLRKQNREHRSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGEVKAGD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0009975 (cyclase activity), GO:0004383 (guanylate cyclase activity), GO:0016849 (phosphorus-oxygen lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0035265 (organ growth), GO:0042330 (taxis), GO:0008283 (cell population proliferation), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0055017 (cardiac muscle tissue growth), GO:0048513 (animal organ development), GO:0033002 (muscle cell proliferation), GO:0016043 (cellular component organization), GO:0006935 (chemotaxis), GO:0060419 (heart growth), GO:0060038 (cardiac muscle cell proliferation), GO:0022008 (neurogenesis), GO:0014855 (striated muscle cell proliferation), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0007507 (heart development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0007411 (axon guidance), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)