Protein: Receptor protein-tyrosine kinase (A6JPX8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single- pass type I membrane protein
InterPro domains:
- IPR050122: Receptor Tyrosine Kinase (family) [58-975]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [834-846]
- IPR036941: Receptor L-domain superfamily (homologous_superfamily) [25-530]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [715-967]
- IPR044912: Epidermal growth factor receptor, juxtamembrane domain (homologous_superfamily) [644-696]
- IPR000719: Protein kinase domain (domain) [713-980]
- IPR006212: Furin-like repeat (repeat) [228-653]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [187-637]
- IPR049328: Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment (domain) [647-682]
- IPR032778: Growth factor receptor domain 4 (domain) [505-637]
- IPR000494: Receptor L-domain (domain) [57-480]
- IPR006211: Furin-like cysteine-rich domain (domain) [188-338]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [713-969]
- IPR016245: Tyrosine protein kinase, EGF/ERB/XmrK receptor (family) [7-1201]
- IPR017441: Protein kinase, ATP binding site (binding_site) [719-746]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [708-1007]
Sequence:
MRPSGTARTKLLLLLAALCAAGGALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALAVLSNYGTNKTGLRELPMRNLQEILIGAVRFSNNPILCNMETIQWRDIVQDVFLSNMSMDVQRHLTGCPKCDPSCPNGSCWGRGEENCQKLTKIICAQQCSRRCRGRSPSDCCHNQCAAGCTGPRESDCLVCHRFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGVSKCKKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPENWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKATNHVCNPLCSSEGCWGPEPTDCVSCQNVSRGRECVDKCNILEGEPREFVENSECIQCHPECLPQTMNITCTGRGPDNCIKCAHYVDGPHCVKTCPSGIMGENNTLVWKFADANNVCHLCHANCTYGCAGPGLKGCQQPEGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMEEEDMEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSANSNSSAVACINRNGSCRVKEDAFLQRYSSDPTSVLTEDNIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLHPAPGRDLHYQNPHSNAVSNPEYLNTAQPTCLSSGFDSSALWIQKGSHQMSLDNPDYQQDFFPKEAKPNGIFKGPTAENAEYLRVAPPSSEFIGA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0044877 (protein-containing complex binding), GO:0038023 (signaling receptor activity), GO:0140096 (catalytic activity, acting on a protein), GO:0042562 (hormone binding), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0005102 (signaling receptor binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0050839 (cell adhesion molecule binding), GO:0019899 (enzyme binding), GO:0005178 (integrin binding), GO:0005516 (calmodulin binding), GO:0019838 (growth factor binding), GO:0016301 (kinase activity), GO:0019199 (transmembrane receptor protein kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0019900 (kinase binding), GO:0019902 (phosphatase binding), GO:0004713 (protein tyrosine kinase activity), GO:0004714 (transmembrane receptor protein tyrosine kinase activity), GO:0019901 (protein kinase binding), GO:0019903 (protein phosphatase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0022414 (reproductive process), GO:0048519 (negative regulation of biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048511 (rhythmic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0048856 (anatomical structure development), GO:0051240 (positive regulation of multicellular organismal process), GO:0042303 (molting cycle), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0009058 (biosynthetic process), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0022404 (molting cycle process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0009605 (response to external stimulus), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0032504 (multicellular organism reproduction), GO:0050793 (regulation of developmental process), GO:0009719 (response to endogenous stimulus), GO:0023051 (regulation of signaling), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0001775 (cell activation), GO:0032879 (regulation of localization), GO:0007623 (circadian rhythm), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0048878 (chemical homeostasis), GO:0044237 (cellular metabolic process), GO:0042698 (ovulation cycle), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0032989 (cellular component morphogenesis), GO:0051047 (positive regulation of secretion), GO:0042633 (hair cycle), GO:0072593 (reactive oxygen species metabolic process), GO:0080134 (regulation of response to stress), GO:0044057 (regulation of system process), GO:0034103 (regulation of tissue remodeling), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0044255 (cellular lipid metabolic process), GO:0042743 (hydrogen peroxide metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0009725 (response to hormone), GO:0010035 (response to inorganic substance), GO:0050878 (regulation of body fluid levels), GO:0045786 (negative regulation of cell cycle), GO:0044260 (cellular macromolecule metabolic process), GO:0045597 (positive regulation of cell differentiation), GO:0045780 (positive regulation of bone resorption), GO:1903829 (positive regulation of protein localization), GO:1901576 (organic substance biosynthetic process), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0034641 (cellular nitrogen compound metabolic process), GO:0061900 (glial cell activation), GO:0043170 (macromolecule metabolic process), GO:2000026 (regulation of multicellular organismal development), GO:0104004 (cellular response to environmental stimulus), GO:0042127 (regulation of cell population proliferation), GO:0006629 (lipid metabolic process), GO:0010941 (regulation of cell death), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0031325 (positive regulation of cellular metabolic process), GO:0070255 (regulation of mucus secretion), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0022405 (hair cycle process), GO:0099177 (regulation of trans-synaptic signaling), GO:0032103 (positive regulation of response to external stimulus), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0009410 (response to xenobiotic stimulus), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0003013 (circulatory system process), GO:0006793 (phosphorus metabolic process), GO:0035295 (tube development), GO:0051726 (regulation of cell cycle), GO:0000902 (cell morphogenesis), GO:0050806 (positive regulation of synaptic transmission), GO:0071214 (cellular response to abiotic stimulus), GO:0001942 (hair follicle development), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0031349 (positive regulation of defense response), GO:0043603 (amide metabolic process), GO:0051962 (positive regulation of nervous system development), GO:0071496 (cellular response to external stimulus), GO:0090066 (regulation of anatomical structure size), GO:1902074 (response to salt), GO:0008284 (positive regulation of cell population proliferation), GO:0050801 (monoatomic ion homeostasis), GO:0009967 (positive regulation of signal transduction), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0009611 (response to wounding), GO:0046887 (positive regulation of hormone secretion), GO:0006979 (response to oxidative stress), GO:0006952 (defense response), GO:0006970 (response to osmotic stress), GO:0098771 (inorganic ion homeostasis), GO:0010817 (regulation of hormone levels), GO:0010033 (response to organic substance), GO:0046883 (regulation of hormone secretion), GO:0009991 (response to extracellular stimulus), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0045907 (positive regulation of vasoconstriction), GO:0051222 (positive regulation of protein transport), GO:0009612 (response to mechanical stimulus), GO:0031099 (regeneration), GO:1903532 (positive regulation of secretion by cell), GO:0030030 (cell projection organization), GO:0006720 (isoprenoid metabolic process), GO:1901654 (response to ketone), GO:1904951 (positive regulation of establishment of protein localization), GO:0010960 (magnesium ion homeostasis), GO:0048143 (astrocyte activation), GO:0048545 (response to steroid hormone), GO:0060251 (regulation of glial cell proliferation), GO:0010001 (glial cell differentiation), GO:0048660 (regulation of smooth muscle cell proliferation), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0043412 (macromolecule modification), GO:0051223 (regulation of protein transport), GO:0045930 (negative regulation of mitotic cell cycle), GO:1902533 (positive regulation of intracellular signal transduction), GO:2000379 (positive regulation of reactive oxygen species metabolic process), GO:0050708 (regulation of protein secretion), GO:0048858 (cell projection morphogenesis), GO:1901701 (cellular response to oxygen-containing compound), GO:0003018 (vascular process in circulatory system), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:0071310 (cellular response to organic substance), GO:0060284 (regulation of cell development), GO:0007423 (sensory organ development), GO:0050804 (modulation of chemical synaptic transmission), GO:0048661 (positive regulation of smooth muscle cell proliferation), GO:0043604 (amide biosynthetic process), GO:0032880 (regulation of protein localization), GO:0060252 (positive regulation of glial cell proliferation), GO:0061008 (hepaticobiliary system development), GO:0036211 (protein modification process), GO:0022008 (neurogenesis), GO:0032870 (cellular response to hormone stimulus), GO:0006954 (inflammatory response), GO:0033993 (response to lipid), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0060429 (epithelium development), GO:0071363 (cellular response to growth factor stimulus), GO:0060541 (respiratory system development), GO:0031347 (regulation of defense response), GO:0009059 (macromolecule biosynthetic process), GO:0007346 (regulation of mitotic cell cycle), GO:0055123 (digestive system development), GO:0032355 (response to estradiol), GO:0008015 (blood circulation), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0032990 (cell part morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0045178 (basal part of cell), GO:0043226 (organelle), GO:0016020 (membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0045177 (apical part of cell), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0045202 (synapse), GO:0016324 (apical plasma membrane), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0098857 (membrane microdomain), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0045121 (membrane raft), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0016323 (basolateral plasma membrane), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus)