Protein: Tyrosine-protein kinase (A6JCB2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton
InterPro domains:
- IPR008266: Tyrosine-protein kinase, active site (active_site) [679-691]
- IPR035849: Fes/Fps/Fer, SH2 domain (domain) [453-537]
- IPR016250: Tyrosine-protein kinase, Fes/Fps type (family) [1-822]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [562-814]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [1-281]
- IPR050198: Non-receptor tyrosine kinases involved in cell signaling (family) [161-814]
- IPR000719: Protein kinase domain (domain) [561-822]
- IPR031160: F-BAR domain (domain) [1-260]
- IPR000980: SH2 domain (domain) [458-549]
- IPR017441: Protein kinase, ATP binding site (binding_site) [567-590]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [561-814]
- IPR001060: FCH domain (domain) [1-94]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [440-578]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [549-818]
Sequence:
MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSWSSGPDSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKLSVLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKSQYRTLTRDSAQARRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHYHQFMLPGLLQSLQDLHEEMAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFEYLGFLRQYGSAPDVPPCVTFDVSLLEEGEQLEPGDLQLNELTLESVQHTLTSVTDELAVATKEVLSRQEMVSQLQRELQCEEQNTHPRERVQLLGKRQVLQEAMQGLQVALCNQDKLQAQQELLQSKMEQLGTGEPPAVPLLQDDRHSTSSTEQERDGGRTPTLEIIKSHFSGIFRPKFSIPPPLQLVPEVQKPLHEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVLWDGQPRHFIIQSSDNLYRLEGDGFPSIPLLITHLLSSQQPLTKKSGVVLFRAVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTICQELQSIRKRHR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0045296 (cadherin binding), GO:0019900 (kinase binding), GO:0051020 (GTPase binding), GO:0003779 (actin binding), GO:0031267 (small GTPase binding), GO:0019901 (protein kinase binding), GO:1990782 (protein tyrosine kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0035265 (organ growth), GO:0008283 (cell population proliferation), GO:0051450 (myoblast proliferation), GO:0009888 (tissue development), GO:0060419 (heart growth), GO:0048731 (system development), GO:0055017 (cardiac muscle tissue growth), GO:0048513 (animal organ development), GO:0033002 (muscle cell proliferation), GO:0007507 (heart development), GO:0060038 (cardiac muscle cell proliferation), GO:0014855 (striated muscle cell proliferation), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005882 (intermediate filament), GO:0045111 (intermediate filament cytoskeleton)