Protein: Origin recognition complex subunit 1 (A0A8M9PM45)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication
Subcellular location: Nucleus
InterPro domains:
- IPR043151: Bromo adjacent homology (BAH) domain superfamily (homologous_superfamily) [9-169]
- IPR003593: AAA+ ATPase domain (domain) [538-689]
- IPR001025: Bromo adjacent homology (BAH) domain (domain) [46-169]
- IPR003959: ATPase, AAA-type, core (domain) [542-684]
- IPR041083: AAA lid domain (domain) [711-754]
- IPR015163: Cdc6, C-terminal (domain) [778-870]
- IPR050311: Origin recognition complex 1/Cell division control protein 6 (family) [102-872]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [497-769]
Sequence:
MSRYITRLSMRRTYKWNGRPVGEDRKLRRQYYGSMSISVDGRTEDVTVSLGQYILIEGENDDNPFVAQLLKLYTDESGKMKTAVVQWFVRMYEVPQYKRKLLGRDPHPQEVFFYQDSSCDNEVDGESILAPVQIMYIAPEHPFPEGKSKDMLFVKHSWDTKSFQAVDPELIEPPPSPKSPPPSSRGPQARPLPTPDPSIMKRAITGAITRGSMSTGKMSSTEAESLHSASKLSAAKALSAKRRSRASSGPHVRKKLELCSPSKNMSRDDVLGEILDKHIDTDKTLMSKMNTSPSGRISISIRLTPLKCNEEQQILPLSSHSPDKPTLTAYGSDSATRARTPSRRKDSASLKEPALTALAEEEHEDSPAQTAATPRSKRKSAQLVSSRIRKQLNLIANKFDLQSDGEDGDEDDCFVPSKIDLQSSSDEELEAKVDSEDELVVKKRRGSRTPRATDKSCVSARTPCKTPSKKAAPSTPRTPRHATPSIPSRTAPARKPGNVLEEARARLHVSAVPESLPCREQEFQDIYNFVESKVIDGTGGCMYISGVPGTGKTATVHEVIRSLQQSAEQDEIPHFNFIEINGMKMTDPHQAYVQILQKLTDQKATSDHAAALLEKRFSAPAPKKETTVLLVDELDLLWTRKQNVMYNLFDWPTRRNARLVVLTIANTMDLPERIMINRVASRLGLTRMSFQPYTFKQLQQIITSRLNRVKAFEEDALQLVSRKVAALSGDARRCLDICRRATEICEHSGNQQKGSGLVGMSHVMEALDEMFSSSYIAAIRSASVQEQLLLRAVIAEFRRLGLEEATFQQVFVQHQALCRVEGLQPVSVSEGLLVCQRLGSCRLLLLEGSRLDLFLRIRLNVSQDDVLYALKAD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0040008 (regulation of growth), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043207 (response to external biotic stimulus), GO:0040014 (regulation of multicellular organism growth), GO:0009620 (response to fungus), GO:0048638 (regulation of developmental growth), GO:0022607 (cellular component assembly), GO:0030030 (cell projection organization), GO:0006996 (organelle organization), GO:0009792 (embryo development ending in birth or egg hatching), GO:0001878 (response to yeast), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0043009 (chordate embryonic development), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000808 (origin recognition complex), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0005664 (nuclear origin of replication recognition complex), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome)