Protein: Protein hsr-9 (Q7JKP6)
Organism: Caenorhabditis elegans
Function: May have a role in DNA double-strand break repair following gamma-irradiation
Subcellular location: Nucleus. Note=Localized to the nuclei of proliferating germ cells
InterPro domains:
- IPR047250: TP53-binding protein 1-like, second BRCT domain (domain) [1050-1143]
- IPR047252: TP53-binding protein 1-like (family) [3-1160]
- IPR047249: TP53-binding protein 1-like, first BRCT domain (domain) [927-1019]
- IPR036420: BRCT domain superfamily (homologous_superfamily) [918-1159]
- IPR056492: Hsr-9, Tudor domain (domain) [738-850]
- IPR001357: BRCT domain (domain) [923-1028]
Sequence:
MASSSNTMEFEEDDSTVTQTSLPTTTSVLDKSRSLFGNSAVISTPARDSTPDGHIVDSSVITKSSVIIEAEDEPDVAADVTALDKEKAEDEPQCSAGKDAKSGESMNDSEKSESPIEEGEGETFEKKIISMDTSDDKLDIAESISVSNDTEKPEENEEKVVGDEDEEDIDDVQEDDEDEAPKKKTKKAVSTSDDDDLHEDDSPKGGSVSDEKEEPENEDDTEEPENEVEVESPVKEQADSGEPIENVNDDKASEPGVGEISQDSVDDSQKIGLDSKSPDGESEANEENQESQSSSRSTRRAKRVSATVSSTPSSNTPRRGGRGQKSEVNADETKTPIVSNSTPRRGRSSRGGDRDEVIDPTENVVGDSGVEETSPRKGRSRRSVATEDTSVTEEVENTEHPTEEETPKQGRGRRSAASSSATSSAVPTPRSTRGRGRKSQANEENLQEKETEDPTKTHDTNQAKSTRTPRGRRSNADAETMESVEAEKVETPTSSRRSTRAKPPAKSAPVTPAVTNKRTTVRGRKKQGSITEDPIEEADETIEETLPQKKGRGAAKSAPSSSKKSAEYDPYDLDTEMEHHPEPLKNIHMEVHNFGAVKYAKLGNSESKYSMTEKAAESRIAELQSSPAAKNRRSLADMTPGKDKMKHRVSSVGTSGRRSRAKKEEEHHENDIEMEDAPATATPASSNRGRKRKSEASDIKTPPAKKEPVIPLKNLSDEDQLLVDHPQDDNEPHAPGARVYAVFQKMFYPAVVLSERDGLGRYKVQFTVDNVIKDVPNSGIIPLRALSPGKTAVYNESDVRLDSGPNDISAAEWKKGKLTISIMDEDGEPTDEVKVVDWYDVSFDHSEWRDYVKSKDQSATAIVTSNITTISEATRARKPTTVSNQAKPKGRKKKGVDLVSSRGGSASPAEEEEKLLPMNEEAIGKNIFTGKVFMLTSANRSNSASVPSMFKKKNLMNFITQNGGIVTEQLNSFQERYSNYEPLLISDTYYRTHKYLAALARGVPCVNNTWLQACGEQGKCVDYTDYVLPAGASIFDESQDMPAPKNPSELLKGTTIYVHSTHSAREVTQTGPGGTFIEIWKPILELLGADVVDGDWETLDETGLKFDVVLVDGTFRDEVMEYADTIGASRVTSEWVIQTIILGKAPEPNAHPKFDPYRLHHRTRH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042393 (histone binding), GO:0140030 (modification-dependent protein binding), GO:0035064 (methylated histone binding), GO:0140034 (methylation-dependent protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0050794 (regulation of cellular process), GO:0007049 (cell cycle), GO:0009893 (positive regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0048523 (negative regulation of cellular process), GO:0033036 (macromolecule localization), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0007059 (chromosome segregation), GO:0044085 (cellular component biogenesis), GO:1903047 (mitotic cell cycle process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0000278 (mitotic cell cycle), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0098813 (nuclear chromosome segregation), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0140014 (mitotic nuclear division), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0006325 (chromatin organization), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0040029 (epigenetic regulation of gene expression), GO:0033365 (protein localization to organelle), GO:0045814 (negative regulation of gene expression, epigenetic), GO:0000819 (sister chromatid segregation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0048285 (organelle fission), GO:0006355 (regulation of DNA-templated transcription), GO:0051276 (chromosome organization), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0034502 (protein localization to chromosome), GO:0045893 (positive regulation of DNA-templated transcription), GO:0000280 (nuclear division), GO:0031507 (heterochromatin formation), GO:0045892 (negative regulation of DNA-templated transcription), GO:0070828 (heterochromatin organization), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0071168 (protein localization to chromatin), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)