Protein: V-type proton ATPase subunit a (A0A8M2BB25)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR026028: ATPase, V0 complex, subunit 116kDa, eukaryotic (family) [1-836]
- IPR002490: V-type ATPase, V0 complex, 116kDa subunit family (family) [4-835]
Sequence:
MGELFRSEEMTLAQLFLQSESAYCCVSELGEIGMVQFRDLNPDVNAFQRKFVNEVRRCEEMDRKLRFVEKEIKKANIPIVDTGENPEVPFPRDMIDLEATFEKLENELKEINTNQEALKKNFLELTELKHILRRTQQFFDEMEDPSLLEESSTLLDPNEVGRAAPLRLGFVAGVIGRERIPTFERMLWRVCRGNVFLRQADIEDPLEDPATGDNVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMAAGVNTRIDDLQMVLNQTEDHRQRVLQAAAKTVRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEIWCPVSDLDSIQFALRRGTERSGSTVPSILNRMQTKQTPPTYNKTNKFTSGFQSIVDAYGISNYREMNPAPYTIITFPFLFAVMFGDLGHGVLMTCAALYLVLRESRLIAQKNDSEMFSMVFAGRYIILLMGLFSMYTGIIYNDCFSKSLNIFGSGWSVRPMFGEKGDNWTFAVLEKSNVLQLNPAVPNVFTGPYPVGIDPIWNIATNKLTFLNSFKMKMSIILGVIHMIFGVSLSLFNHLYFRKPLNIYLGFIPEIIFMVSLFGYLVLLIFYKWIAYDAKSSRVAPSLLITFINMCLFSYNDPTNKPFYTGQVVIQCLLVIIALSCVPCMLIVKTLVMRRQHLWRRHLGTQNFGGIHVGNGPTEDEAEIIQHDQLSQNTEEEPEPSEEEVFNFADEAVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWSMVMHMGLSSRSFGGFIFLSIIFCFFAVLTVFILLVMEGLSAFLHALKLHWVEFQNKFYTGQGFKFMPFTFDSILDGKSEE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015078 (proton transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:0044237 (cellular metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0061919 (process utilizing autophagic mechanism), GO:0009056 (catabolic process), GO:0044085 (cellular component biogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0044248 (cellular catabolic process), GO:0006810 (transport), GO:0048513 (animal organ development), GO:0016043 (cellular component organization), GO:0006914 (autophagy), GO:0016477 (cell migration), GO:0016236 (macroautophagy), GO:0048863 (stem cell differentiation), GO:0048864 (stem cell development), GO:0016192 (vesicle-mediated transport), GO:0043933 (protein-containing complex organization), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0006996 (organelle organization), GO:0022411 (cellular component disassembly), GO:0001667 (ameboidal-type cell migration), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0014033 (neural crest cell differentiation), GO:0097352 (autophagosome maturation), GO:0006909 (phagocytosis), GO:0007033 (vacuole organization), GO:0032984 (protein-containing complex disassembly), GO:0014032 (neural crest cell development), GO:0016050 (vesicle organization), GO:0090497 (mesenchymal cell migration), GO:0090382 (phagosome maturation), GO:0001845 (phagolysosome assembly), GO:0080171 (lytic vacuole organization), GO:0001755 (neural crest cell migration), GO:0007040 (lysosome organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)