Protein: Pro-neuregulin-2, membrane-bound isoform isoform X4 (A0A8M3ALK5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted
InterPro domains:
- IPR013098: Immunoglobulin I-set (domain) [145-230]
- IPR057909: Neuregulin 2, N-terminal domain (domain) [31-120]
- IPR000742: EGF-like domain (domain) [243-284]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [139-239]
- IPR003598: Immunoglobulin subtype 2 (domain) [153-220]
- IPR002154: Neuregulin, C-terminal (domain) [420-617]
- IPR008993: Tissue inhibitor of metalloproteinases-like, OB-fold (homologous_superfamily) [25-127]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [148-232]
- IPR040180: Neuregulin (family) [1-420]
- IPR007110: Immunoglobulin-like domain (domain) [141-231]
- IPR003599: Immunoglobulin domain subtype (domain) [147-231]
- IPR057911: Neuregulin 2, Ig-like domain (domain) [141-230]
Sequence:
MRRLDSVHLSMLLIGVSFACYSPSLNSLQDQAYRSAVVIEGKVQSAPQNVSAEPYSVNVKVLDVWPRNSGGLEREQLVTVGEFGSEAPCTKVKKNHKYIFFMDPTDEPLVFKASFAPLDTSGKNLKKDVGRILCEDCAAFPSLRRMKNPVLADEGSRLIVKCEATGSPAPEYKWYKDGAELKRSKEIKIRNNKKNSKVQIGSAKLEDSGNYTCVAENILGKANGTSTVHVQSITTTVSPGSGHARRCNDTEKTYCVNGGDCYYIHGINQLSCKCPDGYFGPRCLQTEPLRLYMPKPNKKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTNLPPRKQRKKMHNHLRQNIYVDHPNRNLANGPNHPGPGPEEIPMVDYISKNVPATERVIRHGAEAPFPGSRQSSRSHNSSTRAHSSTHRYVSALTTPARLSPVDFHYSLPPQVPTFQITSPNASHAMSLPPAAHAPYPPEEDQPLLRRYQVPLHEARGHEPYRQQQRGSYLRDSTGSLPSSPYRLAQEDEYESTQEYLSSMEQPKRSSRRWRRSRLNGHVAPRGYQPSRDLGSRSCLSDSDSEEEEGESTPFLSMQNMNAAEPSALYRPVPDTRTSHAQSGRHGSRANTQTRLTHSRSKPDNAPH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0061061 (muscle structure development), GO:0009887 (animal organ morphogenesis), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0060343 (trabecula formation), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0003206 (cardiac chamber morphogenesis), GO:0061383 (trabecula morphogenesis), GO:0003205 (cardiac chamber development), GO:0016477 (cell migration), GO:0003208 (cardiac ventricle morphogenesis), GO:0060347 (heart trabecula formation), GO:0048863 (stem cell differentiation), GO:0048864 (stem cell development), GO:0003007 (heart morphogenesis), GO:0007399 (nervous system development), GO:0060415 (muscle tissue morphogenesis), GO:0061384 (heart trabecula morphogenesis), GO:0008544 (epidermis development), GO:0007422 (peripheral nervous system development), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0048644 (muscle organ morphogenesis), GO:0003231 (cardiac ventricle development), GO:0060485 (mesenchyme development), GO:0043588 (skin development), GO:0007517 (muscle organ development), GO:0048762 (mesenchymal cell differentiation), GO:0060429 (epithelium development), GO:0001667 (ameboidal-type cell migration), GO:0007507 (heart development), GO:0014033 (neural crest cell differentiation), GO:0003222 (ventricular trabecula myocardium morphogenesis), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development), GO:0055008 (cardiac muscle tissue morphogenesis), GO:0014032 (neural crest cell development), GO:0098773 (skin epidermis development), GO:0090497 (mesenchymal cell migration), GO:0055010 (ventricular cardiac muscle tissue morphogenesis), GO:0003229 (ventricular cardiac muscle tissue development), GO:0001755 (neural crest cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)