lokahq/bioreason-rl huggingface dataset:
Protein: Actin filament-associated protein 1-like 2 isoform X2 (A0A8M9Q0R8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR030113: Actin-filament associated protein (family) [1-888]
- IPR001849: Pleckstrin homology domain (domain) [205-471]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [182-473]
Sequence:
MDKHKVLEQLLEQLQKFLKILDVEKLSGNAKVQKGLLMELLQSYKSSNGGDEEYIYMNKVIVTCQTQDKTNRDHRPEANGDPSKHISVKNPPEPPPPRPCNTGREPFPLPPAPAPASMENESYYEDPQPYDPISINDFGCFAVITGLRKRVEASNGVVYAVITREDTEQLSSSYESYDEEEVTKGKSTAQHQWPSPEASIELMKDARICAFLWRKKWLGQWAKQLCVVREHRLLCYKSSKDQTPLLDISLLGCSVVYKEKQTKRKEHKLKISPLGAEAIVLGLQSKEQAEQWLKVIQEISPKNTTGSDVTDSPTLICTKGEQSERYSVASESGSSTDSHAENMENKDVKKKYGKFSNLMNIGKKKVCSLESPEKSVDTSGYLNVLVNTQWRSRWCSVKDRQLWIYSDKSKGKVAQQPLSLEGCMVLPDPSPEHLYSFRIQMDGEELAILEAKSSADMGHWLGLILSQTGTKTDPEDLSYDYVNSERISSIVNAAKTSMYLMQRRYSEPNTYTDSPPSDPQTCDDIYDDVPSTENEQEEVQEVQNGSEEGTVNAEEENGKDRVYLDLIPLRSFLHTSSGRVSPQTSSTTQTEISPSTTPHVDDQLKEPVYESSLPTSTENEVPPPVAPRVDTDPSPVPNLHVQPQKISFLGQEIQKKASSTSPLPKTQSLPQTSAQTPQSPPTSRARAASTDRLLDRLKFSPAAGPGSVEVKLGKNRTEADVRRYTDDRDRLEREREEVKNTLATLRKDRREVKDELSSCQDPIRQASLEARLKQMEETCREAERRRVEVELSLMEVKENLRKVESGPFTLGTTVDSSLLEISVHKPAAVSSPAPNTPNNTNINTPACTNNGDSPVNSATALKNRPPSVMAASKGNVLQKAKEWEKKTTT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding), GO:0017124 (SH3 domain binding), GO:0042169 (SH2 domain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0060900 (embryonic camera-type eye formation), GO:0009887 (animal organ morphogenesis), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:0048568 (embryonic organ development), GO:0048562 (embryonic organ morphogenesis), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0002072 (optic cup morphogenesis involved in camera-type eye development), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0016331 (morphogenesis of embryonic epithelium), GO:0002011 (morphogenesis of an epithelial sheet), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0048048 (embryonic eye morphogenesis), GO:0031076 (embryonic camera-type eye development), GO:0061386 (closure of optic fissure), GO:0150063 (visual system development), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0048596 (embryonic camera-type eye morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: dual-specificity kinase (A0A8M2B4K6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR044131: Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain (domain) [100-443]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [235-247]
- IPR000719: Protein kinase domain (domain) [111-438]
- IPR050494: Serine/threonine and dual-specificity kinase (family) [55-439]
- IPR017441: Protein kinase, ATP binding site (binding_site) [117-140]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [99-451]
Sequence:
MSSQHSHPSFSNIHSMADQQQVLSDMTILQRRIPPSFRDPASAPLRKLSVDLIKTYKHINEVYYTKKKRRAQQVPPEDSSTKKERKVYNDGYDDDNYDYIVKNGEKWLDRYEIDSLIGKGSFGQVVKAYDHHEQEWVAIKIIKNKKAFLNQAQIELRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGVPPNHMLDQAPKARKYFDKLSDGLWTVKKNKDIKKVLYPSASEYKPPATRRLHEILGVETGGPGGRRAGEQGHAPCDYLKFKDLILRMLDYDPKTRITPFYALQHNFFKKTTDEGTNTSSSTSTSPAMDHSHSTSTTSSVSSSGGSSGSSNDNRNYRYSNRYYNSAVTHTDYEMQSPQAPSQQQLRIWPGGDSSMGQLSNSGSDSSYPQLLLHKPAATQHSRHFLGNIGGMMEPHHPHPIYGSHHSNGRQLRQQQQQQNQPQGQASQGQQGTALMPVSSPQMQDSIELSLTHHHHLGQSSIMQPPPSSLDSSQYGSSNLHLGLSAFRTRTVMAPQQPPSASQQQLPQAPASQDSMVAASGLGYIPPCYAGSNNNNNPPQGSVGVGAMLTGGPPPRGVGGAGGRPDSEESSMMAVCGSGSGSGQSAANS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009888 (tissue development), GO:0009790 (embryo development), GO:0001704 (formation of primary germ layer), GO:0048598 (embryonic morphogenesis), GO:0007369 (gastrulation), GO:0007492 (endoderm development), GO:0001706 (endoderm formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0045202 (synapse)
Protein: Hyaluronan-mediated motility receptor (RHAMM) isoform X1 (A0A8M9PZ19)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm
InterPro domains:
- IPR031794: Hyaluronan-mediated motility receptor, C-terminal (domain) [755-899]
- IPR026203: Intracellular hyaluronic acid binding protein (family) [1-902]
Sequence:
MSFSRAPLKRFNEHVGCAPPPGTYDVKSGDLKGAASFHKAERFKTAPKTDVPLPSPSKDVLMSPVRRTMSVDGLADALSSKKDKSSFTLEMKHQRLLEKEIRSLVQQRGEQDRRLLALEEELKKLESKLLVAVREKTGLAANVISLERQLAELKKANEFLKTKVSADITKKKINALSMELIEAKNKLDAKDKELSFLQISSEGKVKVLETDLETAKTTFRVLQDRNKDLEDLHQETRAQNELLENEMDKLHNIIQELREEIKALQSYLDSANEEIQDLRIKLQDKSTMERRVSDAQENLSEVEQKLEKCTAELQECQEALKVKEDEVQRSKQELRDSQNALEEKEKEIEQHAQDLQESQSSLKELEERMKQGDRDLEESWSLVRQQEQELARVKEVLRRTEEELDQRVALMGERCSLLEDERAKMQEEGLRQVEELKAELCSLEESRKTETEAYEKLKEEHCAVTKQLEEEKTHSGSLASLLERLRDDTEAERRQLGEELEDALEELVELEKQEQCSEEAIQQLTLNNQTLEQELKKSCAELQKTCAEMQALEEAHVRAIKKLEEDHTSCLAKLGDVTTDFERTRQALGNQKDHAEAQVHQLVEEINQLKQQLQQDQQKLLSQQEIQDQKQEEQARMLLEVQTKLAQREEELKRAAETHSEELRCLQMDVEQERGEKERAQTQLEKEQKRRQSVEGRSAEASRVRSHVEELEDEVSKLRRLMQEERDAAKHHTVEWQQEKQQLCTQIEEERQDLHRQLAEARLQSTSDSETEHWRNLYEELYAKVKPFQEQLDRFAAERSALLNEKGATQAELNKLADAYANLMGHQNQRQKIKHMVKLKEENLELKQEVSKLRSQVGKQKQELDRLKSSETTRRFDPSKAFKHELKENQKPSSALTQGNRYPH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0031099 (regeneration), GO:0042246 (tissue regeneration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Ligand of Numb protein X 2 isoform X1 (A0A8M9PLS6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR001478: PDZ domain (domain) [161-624]
- IPR036034: PDZ superfamily (homologous_superfamily) [149-624]
- IPR051342: PDZ domain-containing scaffold protein (family) [27-621]
Sequence:
MLGNFNSRNLFNHFFCETAKGNPELWCPGTQSQRTKLERTQMEGSEDRVTATNPPKSPQTEIKEDTPSPPAGSNACNNVPTWTEEPGIDNPAFEESTEEDSVHGLECALPRVKRPLSNPCIHLLRTGSSASSGWDFVETLPLSAEEGCVKLPSLPEGEITTIEVHRTNPYSEMGISIVGGNETPLINVVIQEVYRDGVIARDGRLLAGDQILQVNNVDISNVPHNFARSTLARPCATLQLTVLRERRCSARPPAATASPKGSPASIRITLHKRESSEQLGIKLVRRTDEAGVFILDLLEGGLAAKDGRLCSNDRVLAVNEHDLRHGTPELAAQIIQASGERVNLLISRSSKQTMAVHTGSTLTRDIWSHDHIPPLPSTATPSPVPSLHLARSSTQRDLSQCVNCKEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVQPHGCLSRDGRIKRGDVLLSINGQDLTYLSHSEAVGTLKSSATSCSVQLKALEVTMVEEPGLDEELLPPHENDYDASWSPSWVLWLGLPSYLHSSHEIVLRRSHPGSWGFSIVGGYEENHSNQAFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTAGMSHSALVPMLKEQRSRVALTVVSWPGSLI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0035272 (exocrine system development), GO:0055123 (digestive system development), GO:0031016 (pancreas development), GO:0031017 (exocrine pancreas development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0098797 (plasma membrane protein complex), GO:0005886 (plasma membrane)
Protein: Band 4.1-like protein 3 isoform X6 (A0A8M9PU07)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR018980: FERM, C-terminal PH-like domain (domain) [211-301]
- IPR019748: FERM central domain (domain) [84-192]
- IPR008379: Band 4.1, C-terminal (domain) [859-936]
- IPR000798: Ezrin/radixin/moesin-like (family) [14-230]
- IPR007477: SAB domain (domain) [476-523]
- IPR000299: FERM domain (domain) [1-297]
- IPR019749: Band 4.1 domain (domain) [1-192]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [1-81]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [79-186]
- IPR014847: FERM adjacent (domain) [303-349]
- IPR035963: FERM superfamily, second domain (homologous_superfamily) [83-187]
- IPR018979: FERM, N-terminal (domain) [5-67]
- IPR019747: FERM conserved site (conserved_site) [55-191]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [187-296]
Sequence:
MQCKITLLDGSDYTCVVEKRDKGQVLFDKVCEHLNLLEKDYFGITFRDVENQKNWLDPAKDMKKQIRGVAWNFSFNVKFYPPEPALLSEDITRYYLCLQLRDDISSGRLPCSFATHTVLGSYTVQSELGDHDPEECGSEYTSEFRFAPQQTKEMEEKIIDLHKNYKGMTPAEAEMHFLENVKKLSMYGVDLHHAKLIGRFFHCFSPAKGEDSEGVEIMLGVCSSGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLVLPETPPKKFLTLGSKFRYSGRTQAQTRRASSQIVRPAPYFQRSSSKRYTMSRSLDGEMGTALYGAAKGIAMSDLITTVTPEKKVEEEPQPQKHTHADKQMQPQTETETETDTHTQTQTVLVENVMILEDDDETTRATELSLPSPATPARLDTRTDLTDTAVDGELTATESDQEDESEAKTKEADLTPDEQLKPQTNISELKRTFLEGGAEPAGLTEWEKRLSSSPLRSPRREEPPMIEPLELDEIKQEVVVETQEVAETQEVAAALDTQENNRKVDEESDGWVIINKVPPFEAHKAPVETRDKSSIQPEIIVQDASPPAEPMKEFPEDVPAEKMDPEKTTKDEAPPEKTTVEEALPEKTTVDEALPEKTTVDETPLEKTIEKTTVDETPPEKIHSEKTEDVPPKVPPKVPPKVPEKKHSSSYRFLSSMSSAPPPSSVRPRSEDLSAGRISPALLRTSPTAKVPKPSFEEMSPELTALLQSARSWTPVPASASPSASASALVTPAPAALHTPQNQPSESVDEHLGKGLTEEERPADEPLDKPQTGVLSFRSVSGDTHDTHETHDTPVIQTEIKTITYEALQAETDGDADPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVISGDADIDHDED
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0008093 (cytoskeletal anchor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0044087 (regulation of cellular component biogenesis), GO:0050807 (regulation of synapse organization), GO:1901888 (regulation of cell junction assembly), GO:0051963 (regulation of synapse assembly), GO:1904889 (regulation of excitatory synapse assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0019898 (extrinsic component of membrane), GO:0005886 (plasma membrane), GO:0019897 (extrinsic component of plasma membrane)
Protein: Geminin isoform X1 (A0A8M9PAU6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
- IPR022786: Geminin/Multicilin (family) [2-167]
Sequence:
MGRRTLQVLQPSAVNKNLGRIIENGKAVAKRKMWSAEQVKGSKRVKAEVAVKSTNAENENQPEGVTQEAYELMIKETPGSSYWKEVAEERRKALFSVLQENEKLHKDIEAKDEQIAQLKTENEELQELAQHVQHMADMIERLTGKSPDNLEELREIAFDAEDEELENENEDEEEHEDEDQEHDCEGEADESQDTEENPEWSIKHNDSATEES
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:0071840 (cellular component organization or biogenesis), GO:0044085 (cellular component biogenesis), GO:0003002 (regionalization), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0070121 (Kupffer's vesicle development), GO:0009799 (specification of symmetry), GO:0016043 (cellular component organization), GO:0009855 (determination of bilateral symmetry), GO:0030030 (cell projection organization), GO:0060972 (left/right pattern formation), GO:0072359 (circulatory system development), GO:0048732 (gland development), GO:0006996 (organelle organization), GO:0061008 (hepaticobiliary system development), GO:0031016 (pancreas development), GO:0007507 (heart development), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0061371 (determination of heart left/right asymmetry), GO:0007368 (determination of left/right symmetry), GO:0001889 (liver development), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0071910 (determination of liver left/right asymmetry), GO:0060271 (cilium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Mitochondrial Rho GTPase (A0A8M9Q658)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mitochondrial GTPase involved in mitochondrial trafficking
Subcellular location: Membrane; Single- pass type IV membrane protein. Mitochondrion outer membrane; Single-pass type IV membrane protein
InterPro domains:
Sequence:
MRKDVRILLVGEPKVGKTSLIMSLVSEEFPAVVPYRAEEITIPADVTPERVPTHIVDYSEAEQTDEQLFQEISKANVICIVYSVNNQKSIEKVTSHWIPLINERTDKDSRVPLILVGNKSDLVEHSSMETVLPIMNKYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYCPEKKEMRTACVLALTRIFKVSDSDNDGVLNDNELTFFQKTCFNTPLAPQALEDVKNVVRKNISDGVHDNGLTLKGFLFLHTLFIQRGRHETTWAVLRRFGYDDDLELHQDYLFPPLKIPPDSTTELNHDAYLFLQSVFDKHDKDRDGSLSPGELIDLFDVFPYVPWGLDVNSTVCTNDQGWITYQGYLSQWTLTTYLDVQRCLEYLGYLGYSIIAEQESQASAITVTRDKKLDLQKKQTQRNVFRCHVFGITGSGKTGFLQGFLGRNLVHQRAIREEHKSYYAISTAHVYGQEKYLLLHKVFPDFDFLSEMELTCDVACLIYDVSNPCSFEYCAQIFKQYFMDSKTPCMLIAAKSDLPETKQQYGMTPLEFCRKHKMPPPQSYTCNTAGAPSKDIFIKLATMAVYPHIIHAELKNSSLWLKASVGATICAVLGFAIYRTLLRNR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065008 (regulation of biological quality), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0023051 (regulation of signaling), GO:0007017 (microtubule-based process), GO:0051640 (organelle localization), GO:0007018 (microtubule-based movement), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0051646 (mitochondrion localization), GO:0010646 (regulation of cell communication), GO:0051656 (establishment of organelle localization), GO:0060341 (regulation of cellular localization), GO:0001505 (regulation of neurotransmitter levels), GO:0099177 (regulation of trans-synaptic signaling), GO:0032886 (regulation of microtubule-based process), GO:0051588 (regulation of neurotransmitter transport), GO:0051654 (establishment of mitochondrion localization), GO:0046928 (regulation of neurotransmitter secretion), GO:0050804 (modulation of chemical synaptic transmission), GO:0051046 (regulation of secretion), GO:0060632 (regulation of microtubule-based movement), GO:0034643 (establishment of mitochondrion localization, microtubule-mediated), GO:0032386 (regulation of intracellular transport), GO:1902513 (regulation of organelle transport along microtubule)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Rho guanine nucleotide exchange factor 3 (A0A8M2B8P0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases
Subcellular location: Cytoplasm
InterPro domains:
- IPR000219: Dbl homology domain (domain) [122-304]
- IPR001849: Pleckstrin homology domain (domain) [295-451]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [104-319]
- IPR055251: SOS1/NGEF-like, PH domain (domain) [333-446]
- IPR044129: Rho guanine nucleotide exchange factor 3, PH domain (domain) [316-448]
- IPR051480: Endocytic & GEF Adapter (family) [9-482]
- IPR001331: Guanine-nucleotide dissociation stimulator, CDC24, conserved site (conserved_site) [252-277]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [320-454]
Sequence:
MMGCCLFIQQKKKRKQRKRDVDSLSLCSLDINEPSTKRVKPLSRVTSLASLIPPVKAAPLKRIGQTLQRSISFRSDCRPEIMAPRPWSRQVVPTITKRRDSKLWSETFDVGLGHMLSSKEIKRQEAIFELSQGEQDLIEDLKLAKKAYHDPMLKLCIMTEHELNQIFGTLDSLIPLHEDLLSRLRDVRNPDGSTDHMGHILVHWLPCLETYNSYCSNQVAAKALLDHKKQDHRVHDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILKHTPNEHPDRQHLDEAINMIQSIVAGINTQTGESECRYYKERLLYLESGQRDLLIESSRILICHGELKNNRGVKLHVFLFQDVLVITRAISHNEQLWYQLYRQPIPVRDLEWEDLQDGEMRVGGSIRGAFSNNERTKNFFRVMFRCGGQTQMHCFQASDTFNKQQWLNCIRQAKEAVGSAESEPPRSPQMDRERQHNDCSDSNMMDTMEDSSSEYPQMELADIPVSPVRE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0003712 (transcription coregulator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0019207 (kinase regulator activity), GO:0003713 (transcription coactivator activity), GO:0008047 (enzyme activator activity), GO:0030695 (GTPase regulator activity), GO:0019209 (kinase activator activity), GO:0019887 (protein kinase regulator activity), GO:0030295 (protein kinase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048856 (anatomical structure development), GO:0048869 (cellular developmental process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis), GO:0030099 (myeloid cell differentiation), GO:0061515 (myeloid cell development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: dual-specificity kinase (A0A8M2B4L1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR044131: Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain (domain) [175-511]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [310-322]
- IPR000719: Protein kinase domain (domain) [186-506]
- IPR050494: Serine/threonine and dual-specificity kinase (family) [100-507]
- IPR017441: Protein kinase, ATP binding site (binding_site) [192-215]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [174-519]
Sequence:
MVITSSVEEKPQPSNRMVANLPTESWIGSPDQNRFLPQSHLLRKPARSGSSSGCKPPSSTLCQPAALGFSPAEPTMSSQHSHPSFSNIHSMADQQQVLSDMTILQRRIPPSFRDPASAPLRKLSVDLIKTYKHINEVYYTKKKRRAQQVPPEDSSTKKERKVYNDGYDDDNYDYIVKNGEKWLDRYEIDSLIGKGSFGQVVKAYDHHEQEWVAIKIIKNKKAFLNQAQIELRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGVPPNHMLDQAPKARKYFDKLSDGLWTVKKNKDIKKEYKPPATRRLHEILGVETGGPGGRRAGEQGHAPCDYLKFKDLILRMLDYDPKTRITPFYALQHNFFKKTTDEGTNTSSSTSTSPAMDHSHSTSTTSSVSSSGGSSGSSNDNRNYRYSNRYYNSAVTHTDYEMQSPQAPSQQQLRIWPGGDSSMGQLSNSGSDSSYPQLLLHKPAATQHSRHFLGNIGGMMEPHHPHPIYGSHHSNGRQLRQQQQQQNQPQGQASQGQQGTALMPVSSPQMQDSIELSLTHHHHLGQSSIMQPPPSSLDSSQYGSSNLHLGLSAFRTRTVMAPQQPPSASQQQLPQAPASQDSMVAASGLGYIPPCYAGSNNNNNPPQGSVGVGAMLTGGPPPRGVGGAGGRPDSEESSMMAVCGSGSGSGQSAANS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009888 (tissue development), GO:0009790 (embryo development), GO:0001704 (formation of primary germ layer), GO:0048598 (embryonic morphogenesis), GO:0007369 (gastrulation), GO:0007492 (endoderm development), GO:0001706 (endoderm formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0045202 (synapse)