Protein: Polyadenylate-binding protein (A0A7I2YQE4)
Organism: Homo sapiens (Human)
Function: Binds the poly(A) tail of mRNA
Subcellular location: Cytoplasm
InterPro domains:
- IPR045305: PABP, RNA recognition motif 2 (domain) [26-101]
- IPR006515: Polyadenylate binding protein, human types 1, 2, 3, 4 (family) [1-544]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [17-312]
- IPR003954: RNA recognition motif domain, eukaryotic-type (domain) [29-295]
- IPR002004: Polyadenylate-binding protein/Hyperplastic disc protein, C-terminal (domain) [471-548]
- IPR036053: PABC (PABP) domain (homologous_superfamily) [431-562]
- IPR000504: RNA recognition motif domain (domain) [28-299]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [5-303]
Sequence:
MNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0045182 (translation regulator activity), GO:0005488 (binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0090079 (translation regulator activity, nucleic acid binding), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003727 (single-stranded RNA binding), GO:0003729 (mRNA binding), GO:0070717 (poly-purine tract binding), GO:0008187 (poly-pyrimidine tract binding), GO:0003730 (mRNA 3'-UTR binding), GO:0008266 (poly(U) RNA binding), GO:0008143 (poly(A) binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048524 (positive regulation of viral process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0044238 (primary metabolic process), GO:0050792 (regulation of viral process), GO:0048523 (negative regulation of cellular process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0045069 (regulation of viral genome replication), GO:0045070 (positive regulation of viral genome replication), GO:0043487 (regulation of RNA stability), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0009894 (regulation of catabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1903900 (regulation of viral life cycle), GO:0006139 (nucleobase-containing compound metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0034250 (positive regulation of amide metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0043488 (regulation of mRNA stability), GO:0031330 (negative regulation of cellular catabolic process), GO:0010628 (positive regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0034248 (regulation of amide metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0043489 (RNA stabilization), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0010467 (gene expression), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902373 (negative regulation of mRNA catabolic process), GO:0016070 (RNA metabolic process), GO:0061013 (regulation of mRNA catabolic process), GO:1903312 (negative regulation of mRNA metabolic process), GO:0006396 (RNA processing), GO:1902369 (negative regulation of RNA catabolic process), GO:0048255 (mRNA stabilization), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:1900151 (regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay), GO:0006417 (regulation of translation), GO:1903311 (regulation of mRNA metabolic process), GO:0045727 (positive regulation of translation), GO:0010608 (post-transcriptional regulation of gene expression), GO:0031123 (RNA 3'-end processing), GO:2000765 (regulation of cytoplasmic translation), GO:2000767 (positive regulation of cytoplasmic translation), GO:2000622 (regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0043631 (RNA polyadenylation), GO:0006378 (mRNA polyadenylation), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0031124 (mRNA 3'-end processing), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)