Protein: Nociceptin receptor (A0A8M1P286)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [60-312]
- IPR001418: Opioid receptor (family) [70-323]
- IPR001420: X opioid receptor (family) [99-361]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [45-327]
Sequence:
MEFPNDSIGFTDPRHFHLYNESLFQNNFSTFNESDSFFPKGFKITIAVVYMIVCVVGLVGNCLVMYVIIRYTKMKTATNIYIFNLALADALVLATLPFQGTDVFLGFWPFGNALCKVVVSIDYYNMFTSVFTLTVMSMDRYVAVCHPVKALDMRTPHKAKVVNICVWVLASAIGVPAMVLGDVEQDNGESIECILVLPDPRSYWDPVFGTCVFLLSFLIPVAIISVCYSLMVKRLRSVRILSGSKEKDRNLRRITRMVLVVVAAFVVCWTPIQIMALAQSLGFNLASVQTVVFMHFCIALGYVNSSLNPVLYAFLDENFKRCFREFCHPSRFGIDAQQSGRMRHITREVAFNCKTTDGNSNPAXLGVELPLVSPEPQPNPGTGSSSSELTQITTL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0042277 (peptide binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0042923 (neuropeptide binding), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0021675 (nerve development), GO:0035295 (tube development), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0048731 (system development), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0009889 (regulation of biosynthetic process), GO:0009966 (regulation of signal transduction), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0009790 (embryo development), GO:0031323 (regulation of cellular metabolic process), GO:0034220 (monoatomic ion transmembrane transport), GO:0080090 (regulation of primary metabolic process), GO:0050795 (regulation of behavior), GO:0035239 (tube morphogenesis), GO:0072001 (renal system development), GO:0060562 (epithelial tube morphogenesis), GO:0007399 (nervous system development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0021915 (neural tube development), GO:0031326 (regulation of cellular biosynthetic process), GO:0098739 (import across plasma membrane), GO:0048732 (gland development), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0030111 (regulation of Wnt signaling pathway), GO:0002009 (morphogenesis of an epithelium), GO:0051252 (regulation of RNA metabolic process), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0001822 (kidney development), GO:0061008 (hepaticobiliary system development), GO:0010468 (regulation of gene expression), GO:1903522 (regulation of blood circulation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0061333 (renal tubule morphogenesis), GO:0043009 (chordate embryonic development), GO:0001889 (liver development), GO:2000050 (regulation of non-canonical Wnt signaling pathway), GO:2001141 (regulation of RNA biosynthetic process), GO:0043583 (ear development), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)