Protein: Large proline-rich protein BAG6 (A0A7I2V508)
Organism: Homo sapiens (Human)
Function: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC)
Subcellular location: Nucleus. Secreted, extracellular exosome
InterPro domains:
- IPR048926: Bag6, BAG-similar domain (domain) [1100-1152]
- IPR021925: Large proline-rich protein BAG6 (domain) [271-385]
- IPR000626: Ubiquitin-like domain (domain) [17-87]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [10-104]
- IPR019954: Ubiquitin conserved site (conserved_site) [43-68]
Sequence:
MEPNDSTSTAVEEPDSLEVLVKTLDSQTRTFIVGAQMNVKEFKEHIAASVSIPSEKQRLIYQGRVLQDDKKLQEYNVGGKVIHLVERAPPQTHLPSGASSGTGSASATHGGGSPPGTRGPGASVHDRNANSYVMVGTFNLPSDGSAVDVHINMEQAPIQSEPRVRLVMAQHMIRDIQTLLSRMECRGGPQPQHSQPPPQPPAVTPEPVALSSQTSEPVESEAPPREPMEAEEVEERAPAQNPELTPGPAPAGPTPAPETNAPNHPSPAEYVEVLQELQRLESRLQPFLQRYYEVLGAAATTDYNNNHEGREEDQRLINLVGESLRLLGNTFVALSDLRCNLACTPPRHLHVVRPMSHYTTPMVLQQAAIPIQINVGTTVTMTGNGTRPPPTPNAEAPPPGPGQASSVAPSSTNVESSAEGAPPPGPAPPPATSHPRVIRISHQSVEPVVMMHMNIQDSGTQPGGVPSAPTGPLGPPGHGQTLGSTLIQLPSLPPEFMHAVAHQITHQAMVAAVASAAAALFGLSLLPPTGQQVPGFPTAPTRVVIARPTPPQARPSHPGGPPVSGTLQGAGLGTNASLAQMVSGLVGQLLMQPVLVAQGTPGMAPPPAPATASASAGTTNTATTAGPAPGGPAQPPPTPQPSMADLQFSQLLGNLLGPAGPGAGGSGVASPTITVAMPGVPAFLQGMTDFLQATQTAPPPPPPPPPPPPAPEQQTMPPPGSPSGGAGSPGGLGLESLSPEFFTSVVQGVLSSLLGSLGARAGSSESIAAFIQRLSGSSNIFEPGADGALGFFGALLSLLCQNFSMVDVVMLLHGHFQPLQRLQPQLRSFFHQHYLGGQEPTPSNIRMATHTLITGLEEYVRESFSLVQVQPGVDIIRTNLEFLQEQFNSIAAHVLHCTDSGFGARLLELCNQGLFECLALNLHCLGGQQMELAAVINGRIRRMSRGVNPSLVSWLTTMMGLRLQVVLEHMPVGPDAILRYVRRVGDPPQPLPEEPMEVQGAERASPEPQRENASPAPGTTAEEAMSRGPPPAPEGGSRDEQDGASAETEPWAAAVPPEWVPIIQQDIQSQRKVKPQPPLSDAYLSGMPAKRRKTMQGEGPQLLLSEAVSRAAKAAGARPLTSPESLSRDLEAPEVQESYRQQLRSDIQKRLQEDPNYSPQRFPNAQRAFADDP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0019899 (enzyme binding), GO:0005102 (signaling receptor binding), GO:0051787 (misfolded protein binding), GO:0043021 (ribonucleoprotein complex binding), GO:0043022 (ribosome binding), GO:0044389 (ubiquitin-like protein ligase binding), GO:0002020 (protease binding), GO:0031625 (ubiquitin protein ligase binding), GO:1990381 (ubiquitin-specific protease binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0002376 (immune system process), GO:0051641 (cellular localization), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0006807 (nitrogen compound metabolic process), GO:0002684 (positive regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0065008 (regulation of biological quality), GO:0048522 (positive regulation of cellular process), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002253 (activation of immune response), GO:0007165 (signal transduction), GO:0001775 (cell activation), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0012501 (programmed cell death), GO:1905898 (positive regulation of response to endoplasmic reticulum stress), GO:0080134 (regulation of response to stress), GO:0044248 (cellular catabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0051668 (localization within membrane), GO:0046649 (lymphocyte activation), GO:0045184 (establishment of protein localization), GO:0009894 (regulation of catabolic process), GO:0046907 (intracellular transport), GO:0097190 (apoptotic signaling pathway), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0035966 (response to topologically incorrect protein), GO:0050778 (positive regulation of immune response), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0002764 (immune response-regulating signaling pathway), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0051649 (establishment of localization in cell), GO:0031647 (regulation of protein stability), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0080090 (regulation of primary metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0071705 (nitrogen compound transport), GO:0051246 (regulation of protein metabolic process), GO:0051788 (response to misfolded protein), GO:0030163 (protein catabolic process), GO:0071702 (organic substance transport), GO:0072331 (signal transduction by p53 class mediator), GO:1905897 (regulation of response to endoplasmic reticulum stress), GO:0009057 (macromolecule catabolic process), GO:0002429 (immune response-activating cell surface receptor signaling pathway), GO:0006886 (intracellular protein transport), GO:0043412 (macromolecule modification), GO:0015031 (protein transport), GO:0030101 (natural killer cell activation), GO:0097193 (intrinsic apoptotic signaling pathway), GO:0061024 (membrane organization), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0042176 (regulation of protein catabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0071310 (cellular response to organic substance), GO:0010256 (endomembrane system organization), GO:0072594 (establishment of protein localization to organelle), GO:0090150 (establishment of protein localization to membrane), GO:0036211 (protein modification process), GO:0034976 (response to endoplasmic reticulum stress), GO:0035967 (cellular response to topologically incorrect protein), GO:0010243 (response to organonitrogen compound), GO:0044265 (cellular macromolecule catabolic process), GO:0006915 (apoptotic process), GO:1904294 (positive regulation of ERAD pathway), GO:0051247 (positive regulation of protein metabolic process), GO:0045732 (positive regulation of protein catabolic process), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0072657 (protein localization to membrane), GO:0006612 (protein targeting to membrane), GO:0030162 (regulation of proteolysis), GO:0072599 (establishment of protein localization to endoplasmic reticulum), GO:0071218 (cellular response to misfolded protein), GO:0018193 (peptidyl-amino acid modification), GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage), GO:0007029 (endoplasmic reticulum organization), GO:0006605 (protein targeting), GO:0051205 (protein insertion into membrane), GO:0036503 (ERAD pathway), GO:0010498 (proteasomal protein catabolic process), GO:0033365 (protein localization to organelle), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0043543 (protein acylation), GO:0051603 (proteolysis involved in protein catabolic process), GO:0072332 (intrinsic apoptotic signaling pathway by p53 class mediator), GO:1904292 (regulation of ERAD pathway), GO:0045862 (positive regulation of proteolysis), GO:1901800 (positive regulation of proteasomal protein catabolic process), GO:0061136 (regulation of proteasomal protein catabolic process), GO:0042771 (intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator), GO:0019941 (modification-dependent protein catabolic process), GO:0045048 (protein insertion into ER membrane), GO:0030433 (ubiquitin-dependent ERAD pathway), GO:0045047 (protein targeting to ER), GO:1903052 (positive regulation of proteolysis involved in protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:0070972 (protein localization to endoplasmic reticulum), GO:0006473 (protein acetylation), GO:0018205 (peptidyl-lysine modification), GO:0071712 (ER-associated misfolded protein catabolic process), GO:0006620 (post-translational protein targeting to endoplasmic reticulum membrane), GO:0006515 (protein quality control for misfolded or incompletely synthesized proteins), GO:0006511 (ubiquitin-dependent protein catabolic process), GO:0071816 (tail-anchored membrane protein insertion into ER membrane), GO:0006475 (internal protein amino acid acetylation), GO:0018394 (peptidyl-lysine acetylation), GO:0018393 (internal peptidyl-lysine acetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)