lokahq/bioreason-rl huggingface dataset:
Protein: Extracellular sulfatase Sulf-2 isoform X6 (A0A8M9PKK6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell surface. Endoplasmic reticulum. Golgi apparatus, Golgi stack
InterPro domains:
- IPR024607: Sulfatase, conserved site (conserved_site) [88-100]
- IPR000917: Sulfatase, N-terminal (domain) [46-377]
- IPR017850: Alkaline-phosphatase-like, core domain superfamily (homologous_superfamily) [45-836]
- IPR024609: Extracellular sulfatase, C-terminal (domain) [547-678]
- IPR014615: Extracellular sulfatase (family) [10-851]
Sequence:
MAAHGLAARLLPLLLLTMLAVAHASIFLSNQRLKPRFQRDRRNIRPNIILILTDDQDIELGSMQVMNKTRRIMEQGGTHFSNAFVTTPMCCPSRSSMLTGKYAHNHNTYTNNENCSSPSWQAQHEPRTFGVYLNNTGYRTAFFGKYLNEYNGTYIPPGWKEWVAMVKNSRFYNYTLCRNGVREKHGFEYPKDYLTDLITNDSINYFRMSKKIYPHRPVLMVISHAAPHGPEDAAPQYTTAFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLLSVDDSVEKVYNMLVDTGELDNTYVIYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYIRGPNVEAGGINPHIVLNIDLAPTILDIAGMDVPPDMDGKSILKLLDTDRMMNRFQLNKKGKVWRDSFLVERGKLLHKVLNDGKDMAEEENYLPKYQRVKDLCQRAEYQTPCEQIGQKWQCVEDATGKLRLSKCKGMSSLSAVQKPSVSSIKSQLYLQSISTPDVSLNSEPQECNCQPKSYRLSTYSKSKLFSKKKMKSLKSFSRNRFARALSMETGGDLYAVDLDNEHRNLSLRLSTADEDEEFSGAEPTTISQSNSLSVPSSIKVTHRCSILANETVKCDVGLYKSLQAWKDHKLHIDHEIETLQTKIKNLREVRGHLKKARPEECDCNKYYYKSKYKSKLRKYKTGNVHPFRKGQEKDKKAWMMLEQKRRKKLRKLLKRLRNNDTCSMPGLTCFTHDNQHWQTAPFWTLGPFCACTSANNNTYWCMRTINETHNFLFCEFATGFLEYFDINTDPYQLVNAVNTLDRYVLNQLHVQLMELRGCKGHKQCNPRTRSLDMGSFSAGNGLK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0008484 (sulfuric ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0001894 (tissue homeostasis), GO:0060249 (anatomical structure homeostasis), GO:0010669 (epithelial structure maintenance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0009986 (cell surface), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Solute carrier organic anion transporter family member (A0A8M9PU70)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR020846: Major facilitator superfamily domain (domain) [17-649]
- IPR004156: Organic anion transporter polypeptide (family) [7-656]
- IPR036058: Kazal domain superfamily (homologous_superfamily) [447-502]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [8-639]
- IPR002350: Kazal domain (domain) [449-504]
Sequence:
MSTEKKKEPCCSKLKMFLAAMCFVFFAKAFQGSYMKSSVTQIERRFDVPSSLIGFIDGSFEIGNLFVIAFVSYFGAKLHRPRLIAAGCLVMSAGSFITAMPHFFQGQYKYESTISHFSASVNGTENVLPCLTNASLAQDSEIPTVESQAECEKASSSSLWLFVFLGNMLRGIGETPVMPLGLSYLDDFSREENTAFYLALIQTVGIMGPMFGFMLGSFCAKLYVDIGTVDLDSITINYKDSRWVGAWWLGFLVTGGVMLLAGIPFWFLPKSLTRQGEPESEKKPGAPEGGEQERFIPDNNKHNPPASKPAPVTMSALAKDFLPSLKKLFSNTIYVLLVCTGLIQVSGFIGMITFKPKFMEQVYGQSASRAIFLIGIMNLPAVALGIVTGGFIMKRFKVNVLGAAKICIVASVLAFCSMLIQYFLQCDNSQVAGLTVTYQGAPEVSYQTETLISQCNIGCSCSLKHWDPICASNGVTYTSPCLAGCQTSTGIGKEMVFHNCSCIGEALLPYTNMSAVLGQCPRKSDCDFMFKIYMAVTVIGAFFSAVGATPGYIILLRSITPELKSLALGMHTLIVRTLGGIPPPIYFGALIDKTCLKWGLKQCGGRGACRIYDSGAFRNAFLGLIYALYSSSYLLFGLLYNRLSHREKKQALKDQLKAPEQDSCGVSTTNGNASSAIVKCENPDQETTI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0042221 (response to chemical), GO:0009410 (response to xenobiotic stimulus), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015833 (peptide transport), GO:0042886 (amide transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Sodium channel subunit beta-1 (A0A8M2B4J3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, axon. Perikaryon
InterPro domains:
Sequence:
MRGEVVASATVDWWFMAKGESEFTHIYTYAEMTASITDERFEDRLAWNGSKKTDDVQDGSIYILNVTFNDTGTFRCFFDRILIFPNYEYHTNATKFITISVVGHATRGMASILSEVMMYVSIIGLQLWLVVEMVYCYRKIAAAGEEALRESEAEYLAITSESKDNCAGVAVAE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0016247 (channel regulator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0016248 (channel inhibitor activity), GO:0099106 (ion channel regulator activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0008200 (ion channel inhibitor activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0017080 (sodium channel regulator activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005272 (sodium channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005248 (voltage-gated sodium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030018 (Z disc), GO:0099080 (supramolecular complex), GO:0030017 (sarcomere), GO:0031674 (I band), GO:0005737 (cytoplasm), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril)
Protein: Extracellular sulfatase (A0A8M6YXM3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface
InterPro domains:
- IPR024607: Sulfatase, conserved site (conserved_site) [88-100]
- IPR000917: Sulfatase, N-terminal (domain) [46-377]
- IPR017850: Alkaline-phosphatase-like, core domain superfamily (homologous_superfamily) [45-835]
- IPR024609: Extracellular sulfatase, C-terminal (domain) [547-678]
- IPR014615: Extracellular sulfatase (family) [10-848]
Sequence:
MAAHGLAARLLPLLLLTMLAVAHASIFLSNQRLKPRFQRDRRNIRPNIILILTDDQDIELGSMQVMNKTRRIMEQGGTHFSNAFVTTPMCCPSRSSMLTGKYAHNHNTYTNNENCSSPSWQAQHEPRTFGVYLNNTGYRTAFFGKYLNEYNGTYIPPGWKEWVAMVKNSRFYNYTLCRNGVREKHGFEYPKDYLTDLITNDSINYFRMSKKIYPHRPVLMVISHAAPHGPEDAAPQYTTAFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLLSVDDSVEKVYNMLVDTGELDNTYVIYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYIRGPNVEAGGINPHIVLNIDLAPTILDIAGMDVPPDMDGKSILKLLDTDRMMNRFQLNKKGKVWRDSFLVERGKLLHKVLNDGKDMAEEENYLPKYQRVKDLCQRAEYQTPCEQIGQKWQCVEDATGKLRLSKCKGMSSLSAVQKPSVSSIKSQLYLQSISTPDVSLNSEPQECNCQPKSYRLSTYSKSKLFSKKKMKSLKSFSRNRFARALSMETGGDLYAVDLDNEHRNLSLRLSTADEDEEFSGAEPTTISQSNSLSVPSSIKVTHRCSILANETVKCDVGLYKSLQAWKDHKLHIDHEIETLQTKIKNLREVRGHLKKARPEECDCNKYYYKSKYKSKLRKYKTGNVHPFRKGQEKDKKAWMMLEQKRRKKLRKLLKRLRNNDTCSMPGLTCFTHDNQHWQTAPFWTLGPFCACTSANNNTYWCMRTINETHNFLFCEFATGFLEYFDINTDPYQLVNAVNTLDRYVLNQLHVQLMELRGCKGHKQCNPRTRSLDMEDRFGKDGKANVWNDEDVPEDTNLFPGESNWSELEPLYRLDEHAYDLKLNFTLSLEDWAHFSHSVDQMFTLLSNDNQPYTPPHSEDRLTGRGHALVSSSQSASAIYLTTLATPALLLREAGAEVLRDALGLNQQEQHPSNSVQPIGSQVDKSSLDAPLGDLKEDREKERRDEEEEEELRTGRLSSTHCDCNEILQETG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0008484 (sulfuric ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0001894 (tissue homeostasis), GO:0060249 (anatomical structure homeostasis), GO:0010669 (epithelial structure maintenance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0009986 (cell surface), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: ADP-ribosylation factor-like protein 15 isoform X2 (A0A8M9PLJ8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR042292: ADP-ribosylation factor-like protein 15 (family) [148-267]
- IPR006689: Small GTPase superfamily, ARF/SAR type (family) [148-254]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [113-266]
Sequence:
MYWKPKAFYQDLFYLHNRAWDLQRRKRSTELTLLASRFIQILFLTSERRGVLSQSREKKSRLWMHSINGSVSFHSRLDSGILFSGENSKKLSRNYMDYLCFRTLCCKGPPPPRPEYDVVCIGLTGSGKTSLLSRLCSEATDNIVPTTGADSIKKYWSRYYQGSQGVVFVLDSASSEEDLEVARTELHSALQHPQLCTLPFLILANHQDKPAARSVQEIKKYFELEPLARGKSWILEGSTVDNMTAVKESFAQLIHLLEEKDQETGRI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0008047 (enzyme activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0010960 (magnesium ion homeostasis), GO:0055080 (monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Collagen, type XVII, alpha 1a isoform X1 (A0A8M2B6Z2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR008160: Collagen triple helix repeat (repeat) [641-1339]
- IPR050938: Collagen and Collagen-like Structural Proteins (family) [719-1130]
Sequence:
MDKLTTTKIVKVEGGSGGSGKEIQKHTETVTTTRLTSLPPKAHSGQQILTSIGNGSGSAGGAVLLEKKFITHSSAEGGASRSYVISSSSSGSSASSSSGAGSVISGFDGISGEISVTGPITSSTVKSSTSAVKSSSVVSTSITSSSAAGGELSSGYGSISSSSSEFVSGSSGGSISTSEGSMSKSRSGGGSSAVMSGEGTSSSKTVSKFSSSSPSGTRKGLSYSTVPTERKTIMNITTGGYEGSSSGNSSPEYIKKEYVSTSSAATRGRTQTRESEIRARLQSASPSARWTELDDVKRLLKGSRSGSISPPRSPTSTLPIPKKASIDVRHESQSGFDGTVLDAGFSGYYTNPNNLSYTTLQQPSSPTGGMQNNLTLSSSALDTTVYGMQNNLSTSGGAMMANGRCTGYVYGVPKNVGSAGLATTISAIPSSPITADDVFMKDGKLIAIGKENVAAKTETERLIMSKNTGKQFVPSSFNAGADTFSEDSLKREKKMISSATDPQTTTITGSKSSTKNKATYADIRKDDSDGAGCGFWTCCSWWKWLLALLFALLLLLGLLCGLIALGEQLRRLKARVDAIDGGGTSPRTSGLKTDDIPGVQSGNTINLGYEPAGQDSLILQRAILRELQSDTIRASLATSLRGERGEPGPKGDQGPPGVKGDSGFPGIPGPPGLIGHPGQEGPRGPKGSAGESGSDGLPGPRGREGPAGPRGEPGPPGIGEKGEKGSFGDVGAPGIAGPPGPVGPKGDAGAQGVPGLTGAPGPQGFRGDSGDPGPKGDKGPAGPPGVKGDQGERGPRGATGEPGQPGPAGPPGEKGLKGSTGAPGPDGVKGLRGDQGPVGLPGARGPSGPPGDSGIPGTPGLQGPPGLPGTPGQPGAKGEAGEPGRVISAGANANTVAVSGPPGPPGAPGPAGPPGLSGPIGPAGLPGSPGAKGDKGDKGEDGKPGVTESAGTEKSEAGEPGPPGPPGPPGPPGDDGKPGVGEPGPAGPPGEKGEPGSFVPTSETFFAGPPGPPGPIGPKGSQGDVGPQGFPGQPGLPGEPGIGIPGQPGSPGPRGEQGLDGPLGPQGPQGPMGPMGPEGPKGDAGVPGAPGIPGYSYGGGSRSAPGPPGPPGPPGPPGEPGSQGDGSPNAVQQISDYLRSEPIRQYLAGPPGPPGPPGPSGSASDDALASRVIEYLQRDEVRQYLIGPPGPPGPPGVPGGYGFNTQEVAGRVMSLINDAGFRGLPGPPGPPGPQGPPGNSGGLVSYAANENQQHIRAEPQEYIKSHPRADENLDYTAIAKQVSDYIKAHGLLNGNAGFPGAPGRQGYPGPPGFPGEPGTPGQPGPPGQAGPPGLPGPPGLDTVHNYSNMTAVLDYIKENHMKGQKGDLGFPGIPGSPGIDGKQGIVGLPGIKGQKGERGEATYVNRRRRRSTVI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0008544 (epidermis development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0030055 (cell-substrate junction), GO:0030056 (hemidesmosome)
Protein: Glucose-6-phosphate 1-dehydrogenase (A0A8M2B959)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis
InterPro domains:
- IPR022674: Glucose-6-phosphate dehydrogenase, NAD-binding (domain) [54-229]
- IPR001282: Glucose-6-phosphate dehydrogenase (family) [42-530]
- IPR022675: Glucose-6-phosphate dehydrogenase, C-terminal (domain) [231-522]
- IPR019796: Glucose-6-phosphate dehydrogenase, active site (active_site) [219-225]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [49-229]
Sequence:
MMGSRASAERAHTTVPTHSDKMSLPLSRSEVFGQLRKELHDDTAFHQSDVHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDAIRIACMPYMKVVDNEAERLAAFFSRNSYISGKYVEESSFSDLNTHLLSLPGGAEANRLFYLALPPSVYHDVTKNIKHQCMSTKGWNRVIVEKPFGRDLQSSEELSSHLSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSDVVLGQYVGDPDGEGEAKLGYLDDKTVPKGSTQATFATAVLYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFSSQCRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEETELDLTYHSRYRDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIKYKYGSRGPAEADELVQKVGFRYEGTYKWVNPHKL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004345 (glucose-6-phosphate dehydrogenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0009888 (tissue development), GO:0048729 (tissue morphogenesis), GO:0060429 (epithelium development), GO:0002009 (morphogenesis of an epithelium), GO:0002011 (morphogenesis of an epithelial sheet), GO:0090504 (epiboly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Centrosomal protein of 83 kDa (A0A0R4IVY9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR052116: Centrosome and Cilium Assembly Protein (family) [51-707]
Sequence:
MNPPALGQASALFPDLEPPGGVGKATVLLGGSTGLTSSDMEFQKMLIDERMRCENHKTNYQTLKVEHTRLQDQYTRAQNELKRLLSDRQVTQEKQQLLLAELRGELLDKTRDLEELKLQVLTPQRLELLRAQVQQELEAPIRERFNKLQEEAENYRSEYNKLRYDLTFLKSEFDHQKEEHARVLEERRIRHEADVARLEHDKEDLATQLQSGDPARDGKRVEALLREKAQLHQRLRGLEAEVTELRAERNNSGAQAENVQRIQIRQLAESQAAVKALEAEKQSIRMQLDRTESELRLSQEQNTLLTGKLHKAEREINSLNSQVEEMKHTHKLELSNVKLECVRSKGELERERDMLQCQVEGLQSDIEVMKSALERNKELISEKEREMVRRVQAAREEEIHKMATLQEEKLELENRLSELEQQKALQEVTGNSQKEEWEERLRAAQLGEESVRKELQNLRTKVQQQGQQLEELETLKAENADLRQQIAELNLQVGTLSHSESELLDTNNRLRESLERVREDLRSARTQMERTQQEAERLVEERRVEWLEEKHKLQDIEAELREKYSQAKERLQRAAFAQKKRKTMTELKENKLKDKIQLLEAKIAELEIEASAEKKKSSYSEEHAQLSKRLRELQRRHNEFRRLLLGNQMTSSTPLAQSLLIPNESIFSNIQEEQHQRELCVLRRRLEELENSQQQQLEELAAPLDRDRERLSSPRDALPDLS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0030030 (cell projection organization), GO:0022607 (cellular component assembly), GO:0044782 (cilium organization), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0005814 (centriole), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (A0A8M1P9M8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus speckle
InterPro domains:
- IPR044131: Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain (domain) [147-484]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [284-296]
- IPR000719: Protein kinase domain (domain) [160-479]
- IPR050494: Serine/threonine and dual-specificity kinase (family) [74-480]
- IPR017441: Protein kinase, ATP binding site (binding_site) [166-189]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [149-491]
Sequence:
MHTGGETSACKPSSVRLAPSFSFHSAGVQMDAQTPHSHPPFSDAHPQGAADQSAAALPYNPQAPQPSATQVTADMVMLQRRMPQCFRDPATAPLRKLSIELIKTYKHINEVYYAKKKRRHQQGQGEDSSNKKERKIYNDGYDDDNFDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGVPPSHILEQAPKARKFFEKMPDSMWCAKKTKDGKRYKPAGSRKLHSILGVEAGGPGGRRAGESGHAVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSSSVSTSPALEQSQSSGTTSSTSSSSGGSSGTSTSGRARSDPTHQHRHSGGGHFSAAVAMDCHNLCPQARQAFVPALGWVGDGLQQASGETHPVQETTFHVPPHQPKALHPHQHHHHHHHHPPPHGQGPARPRPRLYSPSHSASTQDSMEVTHGHLSMTSLSSSASSSSTSSSSTGNHHYAYQSRPLPHGLGFGHSGSMTLGLGAFSNPRQETGVAGVGLRPGLEREESPMAGVCVQQSSVASS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0035239 (tube morphogenesis), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Stress-activated protein kinase JNK (A0A8M6YUI1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity
Subcellular location: Cytoplasm
InterPro domains:
- IPR003527: Mitogen-activated protein (MAP) kinase, conserved site (conserved_site) [102-204]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [188-200]
- IPR000719: Protein kinase domain (domain) [67-362]
- IPR050117: Mitogen-activated protein (MAP) kinase (family) [65-379]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [55-384]
- IPR008351: Mitogen-activated protein (MAP) kinase, JNK (family) [117-376]
Sequence:
MVFMNRRFLYNCSAPVLDVKIAFCQGFGKQVDVSYIAQHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAGYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPSPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDCLFPADSEHNKLKASQARDLLSKMLIIDPAKRISVDEALQHPYINVWYDPAEVEAARNQQISMPPPQIYDKQLDEREHSIDEWKELIYKEVMNFEERTKNGVVKGQPSPSGTLCA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0048483 (autonomic nervous system development), GO:0007399 (nervous system development), GO:0061008 (hepaticobiliary system development), GO:0048484 (enteric nervous system development), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)