Protein: Tight junction protein 1 (A0A7I2V5U5)
Organism: Homo sapiens (Human)
Subcellular location: Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein; Cytoplasmic side
InterPro domains:
- IPR001452: SH3 domain (domain) [516-584]
- IPR035597: ZO-1, SH3 domain (domain) [517-581]
- IPR008145: Guanylate kinase/L-type calcium channel beta subunit (domain) [606-794]
- IPR005417: Tight junction protein ZO (family) [250-881]
- IPR008144: Guanylate kinase-like domain (domain) [690-791]
- IPR000906: ZU5 domain (domain) [1552-1688]
- IPR036034: PDZ superfamily (homologous_superfamily) [15-518]
- IPR005418: Tight junction protein ZO-1 (family) [344-1455]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [519-595]
- IPR001478: PDZ domain (domain) [23-504]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [628-803]
Sequence:
MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQVYRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding), GO:0045296 (cadherin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0048871 (multicellular organismal-level homeostasis), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0030029 (actin filament-based process), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0044085 (cellular component biogenesis), GO:0051129 (negative regulation of cellular component organization), GO:2000145 (regulation of cell motility), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030155 (regulation of cell adhesion), GO:0045785 (positive regulation of cell adhesion), GO:0032970 (regulation of actin filament-based process), GO:0030036 (actin cytoskeleton organization), GO:0003013 (circulatory system process), GO:0060249 (anatomical structure homeostasis), GO:2000147 (positive regulation of cell motility), GO:0043114 (regulation of vascular permeability), GO:0044087 (regulation of cellular component biogenesis), GO:1904018 (positive regulation of vasculature development), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0009888 (tissue development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0001894 (tissue homeostasis), GO:0051128 (regulation of cellular component organization), GO:0008284 (positive regulation of cell population proliferation), GO:0003018 (vascular process in circulatory system), GO:0022409 (positive regulation of cell-cell adhesion), GO:0008015 (blood circulation), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:1901888 (regulation of cell junction assembly), GO:0022407 (regulation of cell-cell adhesion), GO:0043117 (positive regulation of vascular permeability), GO:0043954 (cellular component maintenance), GO:1901342 (regulation of vasculature development), GO:0045766 (positive regulation of angiogenesis), GO:0032956 (regulation of actin cytoskeleton organization), GO:0030334 (regulation of cell migration), GO:0030855 (epithelial cell differentiation), GO:0022607 (cellular component assembly), GO:0010639 (negative regulation of organelle organization), GO:0002064 (epithelial cell development), GO:0035633 (maintenance of blood-brain barrier), GO:0030335 (positive regulation of cell migration), GO:0033043 (regulation of organelle organization), GO:0045765 (regulation of angiogenesis), GO:0008104 (protein localization), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0031032 (actomyosin structure organization), GO:0034330 (cell junction organization), GO:0042981 (regulation of apoptotic process), GO:0051493 (regulation of cytoskeleton organization), GO:1903670 (regulation of sprouting angiogenesis), GO:1902414 (protein localization to cell junction), GO:0051494 (negative regulation of cytoskeleton organization), GO:2000249 (regulation of actin cytoskeleton reorganization), GO:0043066 (negative regulation of apoptotic process), GO:2000047 (regulation of cell-cell adhesion mediated by cadherin), GO:0034331 (cell junction maintenance), GO:0034329 (cell junction assembly), GO:0007010 (cytoskeleton organization), GO:0045446 (endothelial cell differentiation), GO:2000810 (regulation of bicellular tight junction assembly), GO:0001885 (endothelial cell development), GO:0003158 (endothelium development), GO:0045216 (cell-cell junction organization), GO:1903672 (positive regulation of sprouting angiogenesis), GO:0150105 (protein localization to cell-cell junction), GO:0007043 (cell-cell junction assembly), GO:0034332 (adherens junction organization), GO:0045217 (cell-cell junction maintenance), GO:0061028 (establishment of endothelial barrier), GO:0034334 (adherens junction maintenance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005886 (plasma membrane)