Protein: Methylenetetrahydrofolate reductase (A6IU41)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR004621: Methylenetetrahydrofolate reductase, catalytic domain, eukaryotes (domain) [99-381]
- IPR029041: FAD-linked oxidoreductase-like (homologous_superfamily) [88-379]
- IPR003171: Methylenetetrahydrofolate reductase-like, catalytic domain (domain) [88-377]
- IPR053806: MTHFR, SAM-binding regulatory domain (domain) [384-684]
Sequence:
MNHQKAGVLPDGHCYTSLGMWASEAGCVGLSVPPSISRNPAMSNEARRSGSPSPRSEGSSSGSESSKDSSRCSTPSLDPDRHERLREKMRRRMDSGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLFVDVTWHPAGDPGSDKETSSMMIASTALNYCGLETILHMTCCQQRQEEISGHLHRAKQLGLKNIMALRGDPVGDHWEAEEGGFSYATDLVKHIRNEFGDYFDICVAGYPKGHPDAESFEDDLKHLKEKVSAGADFIITQLFFEASSFFSFVKACEDIGISCPILPGIFPIQGYTSLRQLVKLSKLEVPQTIKDVIEPIKDNDAAIRNYGIELAVNLCRELLDSGLVPGLHFYTLNREVATMEVLKQLGMWTEDPRRPLPWAVSAHPKRREEDVRPIFWASRPKSYIYRTQGWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPREELLKMWGEELTSEESVFEVFEHYLSGEPNRHGYRVTCLPWNDEPLAAETSLMKEELLRVNRLGILTINSQPNINGKPSSDPVVGWGPSGGYVFQKAYLEFFTSRETVEALLQVLKTYELRVNYHIVDVKGENITNAPELQPNAVTWGIFPGREIVQPTVVDPISFMFWKDEAFALWIEQWGKLYEEESPSRMIIQYIHDNYFLVNLVDNEFLLDNCLWQVVEDTFELLNRHTTKKEAQAP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016491 (oxidoreductase activity), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0016645 (oxidoreductase activity, acting on the CH-NH group of donors), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0050660 (flavin adenine dinucleotide binding), GO:0016646 (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor), GO:0017076 (purine nucleotide binding), GO:0030554 (adenyl nucleotide binding), GO:0050661 (NADP binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0001101 (response to acid chemical), GO:0009991 (response to extracellular stimulus), GO:0001666 (response to hypoxia), GO:0006575 (cellular modified amino acid metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0009410 (response to xenobiotic stimulus), GO:0046483 (heterocycle metabolic process), GO:0006082 (organic acid metabolic process), GO:0070482 (response to oxygen levels), GO:0046500 (S-adenosylmethionine metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0006790 (sulfur compound metabolic process), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0034097 (response to cytokine), GO:0043200 (response to amino acid), GO:0010243 (response to organonitrogen compound), GO:0000096 (sulfur amino acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0031667 (response to nutrient levels), GO:0036293 (response to decreased oxygen levels), GO:0014070 (response to organic cyclic compound), GO:0006760 (folic acid-containing compound metabolic process), GO:0033273 (response to vitamin), GO:0042558 (pteridine-containing compound metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0051593 (response to folic acid), GO:0019752 (carboxylic acid metabolic process), GO:0050667 (homocysteine metabolic process), GO:0070555 (response to interleukin-1), GO:0046653 (tetrahydrofolate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0045202 (synapse)