Protein: Protein disulfide-isomerase (A0A7P0T8J3)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane; Peripheral membrane protein. Endoplasmic reticulum lumen. Melanosome. Membrane; Peripheral membrane protein
InterPro domains:
- IPR005792: Protein disulphide isomerase (family) [25-488]
- IPR017937: Thioredoxin, conserved site (conserved_site) [45-387]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [24-452]
- IPR005788: Protein disulfide-isomerase, thioredoxin-like domain (domain) [30-451]
- IPR013766: Thioredoxin domain (domain) [8-455]
Sequence:
MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGDDDDLEDLEEAEEPDMEEDDDQKAVKDEL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:0016491 (oxidoreductase activity), GO:0016853 (isomerase activity), GO:1901363 (heterocyclic compound binding), GO:0044877 (protein-containing complex binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0050839 (cell adhesion molecule binding), GO:0005178 (integrin binding), GO:0008092 (cytoskeletal protein binding), GO:0003676 (nucleic acid binding), GO:0003756 (protein disulfide isomerase activity), GO:0005102 (signaling receptor binding), GO:0016860 (intramolecular oxidoreductase activity), GO:0046983 (protein dimerization activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0015035 (protein-disulfide reductase activity), GO:0031543 (peptidyl-proline dioxygenase activity), GO:0016670 (oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor), GO:0046982 (protein heterodimerization activity), GO:0003779 (actin binding), GO:0016864 (intramolecular oxidoreductase activity, transposing S-S bonds), GO:0003723 (RNA binding), GO:0015036 (disulfide oxidoreductase activity), GO:0031545 (peptidyl-proline 4-dioxygenase activity), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0048524 (positive regulation of viral process), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043903 (regulation of biological process involved in symbiotic interaction), GO:0006457 (protein folding), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0050792 (regulation of viral process), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0001666 (response to hypoxia), GO:1901564 (organonitrogen compound metabolic process), GO:0080134 (regulation of response to stress), GO:0070482 (response to oxygen levels), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0030155 (regulation of cell adhesion), GO:0045785 (positive regulation of cell adhesion), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0034975 (protein folding in endoplasmic reticulum), GO:1903900 (regulation of viral life cycle), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0007166 (cell surface receptor signaling pathway), GO:0052372 (modulation by symbiont of entry into host), GO:1903902 (positive regulation of viral life cycle), GO:0046596 (regulation of viral entry into host cell), GO:0071456 (cellular response to hypoxia), GO:0010811 (positive regulation of cell-substrate adhesion), GO:0034097 (response to cytokine), GO:0071453 (cellular response to oxygen levels), GO:0010810 (regulation of cell-substrate adhesion), GO:0071310 (cellular response to organic substance), GO:0043067 (regulation of programmed cell death), GO:2001233 (regulation of apoptotic signaling pathway), GO:1900407 (regulation of cellular response to oxidative stress), GO:0036211 (protein modification process), GO:0034976 (response to endoplasmic reticulum stress), GO:0043412 (macromolecule modification), GO:1903201 (regulation of oxidative stress-induced cell death), GO:0036293 (response to decreased oxygen levels), GO:1902882 (regulation of response to oxidative stress), GO:0019221 (cytokine-mediated signaling pathway), GO:1902531 (regulation of intracellular signal transduction), GO:1900024 (regulation of substrate adhesion-dependent cell spreading), GO:2001242 (regulation of intrinsic apoptotic signaling pathway), GO:0042981 (regulation of apoptotic process), GO:1902175 (regulation of oxidative stress-induced intrinsic apoptotic signaling pathway), GO:1900026 (positive regulation of substrate adhesion-dependent cell spreading), GO:0018126 (protein hydroxylation), GO:0018193 (peptidyl-amino acid modification), GO:0071345 (cellular response to cytokine stimulus), GO:0036294 (cellular response to decreased oxygen levels), GO:0019511 (peptidyl-proline hydroxylation), GO:0018208 (peptidyl-proline modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)