Protein: RNA polymerase II subunit A C-terminal domain phosphatase (A6K5H7)
Organism: Rattus norvegicus (Rat)
Function: This promotes the activity of RNA polymerase II
Subcellular location: Nucleus
InterPro domains:
- IPR023214: HAD superfamily (homologous_superfamily) [169-312]
- IPR058785: FCP1, barrel-sandwich hybrid domain (domain) [20-113]
- IPR004274: FCP1 homology domain (domain) [174-340]
- IPR036420: BRCT domain superfamily (homologous_superfamily) [615-727]
- IPR015388: FCP1-like phosphatase, C-terminal (domain) [715-969]
- IPR011947: FCP1-like phosphatase, phosphatase domain (domain) [173-319]
- IPR039189: CTD phosphatase Fcp1 (family) [82-865]
- IPR036412: HAD-like superfamily (homologous_superfamily) [170-321]
- IPR001357: BRCT domain (domain) [628-727]
Sequence:
MEAPPLAGVPTECTPAVAGAEVRCPGPAPLRLLEWKVTAGATVRIGSVLAVYEAAVSAQPAGPAPARAASGGCVRASRTERRLRSERAGVVRELCAQPGQVVAPGALLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMQAEKLGREDQQRLHRNRKLVLMVDLDQTLIHTTEQHCPQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILSRDECIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFPGTGDVNAPPGARESQTRKKVNHSSKGADILEQALPVKDPEEGKPPGVEQSNGLGKASRELNGGEAVPGVFSSKTDEKETWSLTRASPASSSGGRELTEAPELPVSCEWDSRTAPGAHPTQGDATQGLDFDLSSDSESSESSRSEGQKSFSSASDGENEERRRRKKSPATQDRTKVPQHSGPHDTSGGRSAASPSGESGPLHPHDKVSDPDTQEEGERDSLCGLGNGSVDRKEAETESQNSEQSGVTAGESLDQSVGEEEEEDTDDDDHLIHLEEILVRVHTDYYTKYDRYLNKELEEAPDIRKIVPELKSKVLADVAVIFSGLHPTNFPVEKTREHYHATALGAKVLTQLVLSPDAPDRATHLIAARAGTEKVRQAQECKHLHVVSPEWLWSCLERWDKVEEQLFPLMDEDTRTHRDNSPAVFPDRHSMLPTALFHPTPIHSKAHPGPEVRIYDSNTGKLIRMGTQGPAPALSSAPLIHGEPSSFRAVQPHQQQMFGEELPESQDGEQPGPARRKRQPSMSETMPLYTLCKEDLESMDKEVDDILGEGSDDSESEKKKAEDQDSEQERARKPRKPRAPGTRREQPAGLPSPGERSAAGTRAPRGHKRKLNEEDAASESSGESSNDDEEGSSSEADEMAAALEAELNDLM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004722 (protein serine/threonine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0045926 (negative regulation of growth), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0040008 (regulation of growth), GO:2000026 (regulation of multicellular organismal development), GO:0045596 (negative regulation of cell differentiation), GO:0048640 (negative regulation of developmental growth), GO:0046621 (negative regulation of organ growth), GO:0001558 (regulation of cell growth), GO:0044057 (regulation of system process), GO:0030308 (negative regulation of cell growth), GO:0045595 (regulation of cell differentiation), GO:0046620 (regulation of organ growth), GO:0043502 (regulation of muscle adaptation), GO:0051128 (regulation of cellular component organization), GO:0014741 (negative regulation of muscle hypertrophy), GO:0048638 (regulation of developmental growth), GO:0055022 (negative regulation of cardiac muscle tissue growth), GO:0055021 (regulation of cardiac muscle tissue growth), GO:0060420 (regulation of heart growth), GO:0061117 (negative regulation of heart growth), GO:0010611 (regulation of cardiac muscle hypertrophy), GO:0061050 (regulation of cell growth involved in cardiac muscle cell development), GO:0051148 (negative regulation of muscle cell differentiation), GO:0090257 (regulation of muscle system process), GO:0010614 (negative regulation of cardiac muscle hypertrophy), GO:0051147 (regulation of muscle cell differentiation), GO:0051154 (negative regulation of striated muscle cell differentiation), GO:0014743 (regulation of muscle hypertrophy), GO:0051153 (regulation of striated muscle cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)