Protein: Serine hydroxymethyltransferase (A6HQW0)
Organism: Rattus norvegicus (Rat)
Function: Interconversion of serine and glycine
InterPro domains:
- IPR015421: Pyridoxal phosphate-dependent transferase, major domain (homologous_superfamily) [78-352]
- IPR015424: Pyridoxal phosphate-dependent transferase (homologous_superfamily) [43-519]
- IPR049943: Serine hydroxymethyltransferase-like (family) [37-520]
- IPR039429: Serine hydroxymethyltransferase-like domain (domain) [49-448]
- IPR001085: Serine hydroxymethyltransferase (family) [44-519]
- IPR015422: Pyridoxal phosphate-dependent transferase, small domain (homologous_superfamily) [53-516]
- IPR019798: Serine hydroxymethyltransferase, pyridoxal phosphate binding site (binding_site) [272-288]
Sequence:
MVPFSLLRTTRPLQRCGQLVCMAARAQHSEVAQKQAGEAAGGWTGQESLSDSDPEIWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAAYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNPQTGLIDYDQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKYADIVTTTTHKTLRGARSGLIFYRKGVRTVDPKTGQEIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLRNAQAMADALLKRGYSLVSGGTDTHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKRKTAPGPAQWPSDQLFSPFSAKLQDFKSFLLKDPETSQRLANLRQQVEQFARGFPMPGFDER
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0016740 (transferase activity), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0019842 (vitamin binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0043177 (organic acid binding), GO:0043168 (anion binding), GO:0042802 (identical protein binding), GO:0070279 (vitamin B6 binding), GO:0016832 (aldehyde-lyase activity), GO:0016742 (hydroxymethyl-, formyl- and related transferase activity), GO:0031406 (carboxylic acid binding), GO:0030170 (pyridoxal phosphate binding), GO:0004372 (glycine hydroxymethyltransferase activity), GO:0016597 (amino acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0048522 (positive regulation of cellular process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:0008284 (positive regulation of cell population proliferation), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0009069 (serine family amino acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0009070 (serine family amino acid biosynthetic process), GO:0006544 (glycine metabolic process), GO:0006563 (L-serine metabolic process), GO:0006564 (L-serine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005759 (mitochondrial matrix), GO:0031970 (organelle envelope lumen), GO:0070013 (intracellular organelle lumen), GO:0031966 (mitochondrial membrane), GO:0005758 (mitochondrial intermembrane space), GO:0005743 (mitochondrial inner membrane)