Protein: Integrin, alpha 2 (A6I5T2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR048285: Integrin alpha, second immunoglobulin-like domain (domain) [786-928]
- IPR013519: Integrin alpha beta-propellor (repeat) [31-661]
- IPR028994: Integrin alpha, N-terminal (homologous_superfamily) [27-650]
- IPR048286: Integrin alpha, third immunoglobulin-like domain (domain) [950-1040]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [649-1094]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [166-361]
- IPR013517: FG-GAP repeat (repeat) [488-586]
- IPR002035: von Willebrand factor, type A (domain) [169-359]
- IPR000413: Integrin alpha chain (family) [431-1120]
- IPR018184: Integrin alpha chain, C-terminal cytoplasmic region, conserved site (conserved_site) [1113-1127]
Sequence:
MGPGQAGGALLLQLLLLTQGLLSCLAYNVGLPGAKIFSGSSSEQFGYSVQQLTTPQGNWLLVGSPWSGFPDNRMGDVYKCPVDLPTATCEKLNLQNSASISNVTEIKTNMSLGLTLTRNPGTGGFLTCGPLWAHQCGNQYYATGICSDVSPDFQSLTSFSPAVQACPSLVDVVVVCDESNSIYPWEAVKNFLEKFVQGLDIGPKKTQVALIQYANDPRVVFNLTTYKNKEDMVQATSETRQYGGDLTNTFKAIQFARDIAYLPESGGRPGATKVMVVVTDGESHDGSKLQTVIQQCNDDEILRFGIAVLGYLNRNALDTKNLIKEIKAIASTPTERYFFNVADEAALLEKAGTLGEHIFSIEGTVQGGDNFQMEMAQVGFSADYSPQNDILMLGAVGAFDWSGTVVQETSYEHLIFPKQAFDQVLQDRNHSSFLGYSVAAISTENGVHFVAGAPRANYTGQIVLYSVNKHGNVTVIQSHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMNDLKKEEGKVYLFTITKGVLNQHQFLEGPEGTGNARFGSAIAALSDINMDGFNDVIVGSPVENENSGAVYIYNGHQGTIRTKYSQKILGSDGAFKSHLQFFGRSLDGYGDLNGDSITDVSIGALGQVVQLWSQSVADVATEASFTPDKIILLNKEAKITLKLCFRAKFRPPGQNHQVAILFNMTLDADQYSSRVTSRGIFRENSERFLQKTMVVSEVENCSEYHISIQKPSDVVNPLDLRVDISLEKPGTSPALEAYSETVKVFSIPFYKECGSDGICISDLILDVRQLPALRNQPFIVSNQNKRLTFSVTLKNRGESAYNTAVLAEFSENLFFASFSMPVDGTEVTCQIGSSQKSVTCDVGYPALKSEQQVTFTINFDFNLQNLQNQAAINFQAFSESQETNKADNSVSLIVPLLYDAELHLTRSTNINFYEISSDENAPSVINSVEDIGPEFIFSLKITAGSAPVSMASVTIHIPLHTKEKNPLLYLTGIQTDKAGDISCRAEINPLNLPHTASPVSFKSENFRHMKELSTFQTVQLTAAAEIDTHNPQLFVIEENAVTIPLMIMKPTEKAEVPTGVIIGSIIAGILLLLAMVAGLWKLGFFKRQYKKMGQNPDETDETTELNS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0050840 (extracellular matrix binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding), GO:0005178 (integrin binding), GO:0005518 (collagen binding), GO:0005102 (signaling receptor binding), GO:0043236 (laminin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0022414 (reproductive process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0008283 (cell population proliferation), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0044706 (multi-multicellular organism process), GO:0009719 (response to endogenous stimulus), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0044703 (multi-organism reproductive process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0007155 (cell adhesion), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0014823 (response to activity), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0051606 (detection of stimulus), GO:0048522 (positive regulation of cellular process), GO:0009581 (detection of external stimulus), GO:0001666 (response to hypoxia), GO:0032103 (positive regulation of response to external stimulus), GO:0044085 (cellular component biogenesis), GO:2000145 (regulation of cell motility), GO:0002685 (regulation of leukocyte migration), GO:0009410 (response to xenobiotic stimulus), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0070482 (response to oxygen levels), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0010714 (positive regulation of collagen metabolic process), GO:0050766 (positive regulation of phagocytosis), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0009582 (detection of abiotic stimulus), GO:0031646 (positive regulation of nervous system process), GO:0060627 (regulation of vesicle-mediated transport), GO:0051098 (regulation of binding), GO:0010712 (regulation of collagen metabolic process), GO:0009725 (response to hormone), GO:0045184 (establishment of protein localization), GO:0010632 (regulation of epithelial cell migration), GO:0009887 (animal organ morphogenesis), GO:0014850 (response to muscle activity), GO:0071214 (cellular response to abiotic stimulus), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0031349 (positive regulation of defense response), GO:0051128 (regulation of cellular component organization), GO:0071496 (cellular response to external stimulus), GO:0031589 (cell-substrate adhesion), GO:1902074 (response to salt), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0009611 (response to wounding), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0050920 (regulation of chemotaxis), GO:0006970 (response to osmotic stress), GO:1901700 (response to oxygen-containing compound), GO:0051130 (positive regulation of cellular component organization), GO:0045785 (positive regulation of cell adhesion), GO:0050906 (detection of stimulus involved in sensory perception), GO:0010033 (response to organic substance), GO:2000147 (positive regulation of cell motility), GO:0009891 (positive regulation of biosynthetic process), GO:0002687 (positive regulation of leukocyte migration), GO:0009991 (response to extracellular stimulus), GO:0104004 (cellular response to environmental stimulus), GO:0007565 (female pregnancy), GO:0042127 (regulation of cell population proliferation), GO:0045933 (positive regulation of muscle contraction), GO:0007584 (response to nutrient), GO:0009888 (tissue development), GO:1901698 (response to nitrogen compound), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0009889 (regulation of biosynthetic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0050877 (nervous system process), GO:0080090 (regulation of primary metabolic process), GO:0009612 (response to mechanical stimulus), GO:0045807 (positive regulation of endocytosis), GO:0050921 (positive regulation of chemotaxis), GO:0031347 (regulation of defense response), GO:0032967 (positive regulation of collagen biosynthetic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0032355 (response to estradiol), GO:0051246 (regulation of protein metabolic process), GO:0048732 (gland development), GO:0090257 (regulation of muscle system process), GO:0043588 (skin development), GO:0050982 (detection of mechanical stimulus), GO:0030334 (regulation of cell migration), GO:0033273 (response to vitamin), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0007160 (cell-matrix adhesion), GO:0048660 (regulation of smooth muscle cell proliferation), GO:0050974 (detection of mechanical stimulus involved in sensory perception), GO:0050927 (positive regulation of positive chemotaxis), GO:0031667 (response to nutrient levels), GO:0050729 (positive regulation of inflammatory response), GO:0031644 (regulation of nervous system process), GO:0036293 (response to decreased oxygen levels), GO:1905155 (positive regulation of membrane invagination), GO:0062149 (detection of stimulus involved in sensory perception of pain), GO:0030335 (positive regulation of cell migration), GO:0043085 (positive regulation of catalytic activity), GO:1901701 (cellular response to oxygen-containing compound), GO:0006971 (hypotonic response), GO:0030100 (regulation of endocytosis), GO:0009743 (response to carbohydrate), GO:0050926 (regulation of positive chemotaxis), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0031344 (regulation of cell projection organization), GO:0034250 (positive regulation of amide metabolic process), GO:0071310 (cellular response to organic substance), GO:0051336 (regulation of hydrolase activity), GO:1905153 (regulation of membrane invagination), GO:0048661 (positive regulation of smooth muscle cell proliferation), GO:0010628 (positive regulation of gene expression), GO:0071107 (response to parathyroid hormone), GO:0007600 (sensory perception), GO:0061008 (hepaticobiliary system development), GO:0030855 (epithelial cell differentiation), GO:0051099 (positive regulation of binding), GO:0033591 (response to L-ascorbic acid), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0042060 (wound healing), GO:0050764 (regulation of phagocytosis), GO:0032965 (regulation of collagen biosynthetic process), GO:0034248 (regulation of amide metabolic process), GO:0010243 (response to organonitrogen compound), GO:0050727 (regulation of inflammatory response), GO:0051969 (regulation of transmission of nerve impulse), GO:0031346 (positive regulation of cell projection organization), GO:0060100 (positive regulation of phagocytosis, engulfment), GO:0033993 (response to lipid), GO:0031326 (regulation of cellular biosynthetic process), GO:0010634 (positive regulation of epithelial cell migration), GO:0051101 (regulation of DNA binding), GO:0051247 (positive regulation of protein metabolic process), GO:0045987 (positive regulation of smooth muscle contraction), GO:0071260 (cellular response to mechanical stimulus), GO:0014070 (response to organic cyclic compound), GO:0008104 (protein localization), GO:0060429 (epithelium development), GO:0034330 (cell junction organization), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0030879 (mammary gland development), GO:0010921 (regulation of phosphatase activity), GO:0045937 (positive regulation of phosphate metabolic process), GO:0034329 (cell junction assembly), GO:0001889 (liver development), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0051345 (positive regulation of hydrolase activity), GO:0014911 (positive regulation of smooth muscle cell migration), GO:0006937 (regulation of muscle contraction), GO:0071392 (cellular response to estradiol stimulus), GO:0014075 (response to amine), GO:0070365 (hepatocyte differentiation), GO:0043388 (positive regulation of DNA binding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0044306 (neuron projection terminus), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098793 (presynapse), GO:0009986 (cell surface), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0043679 (axon terminus), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0070161 (anchoring junction), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0030055 (cell-substrate junction), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0005925 (focal adhesion), GO:0030424 (axon), GO:0005634 (nucleus)