Protein: CASP8 and FADD-like apoptosis regulator, isoform CRA_a (F7FBZ4)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR011029: Death-like domain superfamily (homologous_superfamily) [3-191]
- IPR001309: Peptidase C14, p20 domain (domain) [268-363]
- IPR029030: Caspase-like domain superfamily (homologous_superfamily) [234-477]
- IPR011600: Peptidase C14, caspase domain (domain) [267-475]
- IPR001875: Death effector domain (domain) [6-178]
- IPR015917: Peptidase C14A, caspase catalytic domain (domain) [248-479]
Sequence:
MALSTVSAEVIHQVEESLDEDEKEMMLFLCRDVTENLAPPNVRDLLDCLSERGQLSFAALAELLYRVRRFDLLKRILKTDKAAVEDHLCRSPHLVSDYRVLLMEIGENLNQSDVSSLIFLTKDYTGRGKVAKDKSFLDLVIELEKLNLIGSDQLNLLEKCLKSIHRIDLKTKIQKYTQSSQEARSNMNALQASLPKLSIKEHLYNSRLQNGRSKEPRFVEHHGIQRKPVKTSIQESGIFLPPHIHEESYRMQSKPLGICLIIDCIGNDTEYLRETFTSLGYRVQPFLFPSSHEITQIVRRFSNMTQHQDYDSFVCVLVSRGGSQSMMGVDQVYSGFSLENVKDMFKGDMCPSLRGKPKLFFIQNYEALEDNSLEVDGPAIKNVNSRHLHPRHCTTHPDADIFWSLCTADVSRLEQPSSSLSVYLQKLSQLLEQGRKRSLVDLHVELMDKVYAWNSNVPSKEKYYLSLQHTLRKKLILSHT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0005102 (signaling receptor binding), GO:0005126 (cytokine receptor binding), GO:0002020 (protease binding), GO:0032813 (tumor necrosis factor receptor superfamily binding), GO:0005123 (death receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0009967 (positive regulation of signal transduction), GO:0001666 (response to hypoxia), GO:0060548 (negative regulation of cell death), GO:0070482 (response to oxygen levels), GO:0070848 (response to growth factor), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0051130 (positive regulation of cellular component organization), GO:0090288 (negative regulation of cellular response to growth factor stimulus), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0010035 (response to inorganic substance), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0009889 (regulation of biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0051128 (regulation of cellular component organization), GO:0008284 (positive regulation of cell population proliferation), GO:0071456 (cellular response to hypoxia), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:1903055 (positive regulation of extracellular matrix organization), GO:0070849 (response to epidermal growth factor), GO:1901654 (response to ketone), GO:0031344 (regulation of cell projection organization), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:0032355 (response to estradiol), GO:0071453 (cellular response to oxygen levels), GO:0043069 (negative regulation of programmed cell death), GO:0071310 (cellular response to organic substance), GO:0043067 (regulation of programmed cell death), GO:2000378 (negative regulation of reactive oxygen species metabolic process), GO:1903427 (negative regulation of reactive oxygen species biosynthetic process), GO:0048545 (response to steroid hormone), GO:1901699 (cellular response to nitrogen compound), GO:0071731 (response to nitric oxide), GO:0050678 (regulation of epithelial cell proliferation), GO:0050679 (positive regulation of epithelial cell proliferation), GO:0043434 (response to peptide hormone), GO:0032870 (cellular response to hormone stimulus), GO:0010243 (response to organonitrogen compound), GO:0071241 (cellular response to inorganic substance), GO:0031346 (positive regulation of cell projection organization), GO:0033993 (response to lipid), GO:0036293 (response to decreased oxygen levels), GO:1903426 (regulation of reactive oxygen species biosynthetic process), GO:1903053 (regulation of extracellular matrix organization), GO:1902533 (positive regulation of intracellular signal transduction), GO:0014070 (response to organic cyclic compound), GO:1903844 (regulation of cellular response to transforming growth factor beta stimulus), GO:1901701 (cellular response to oxygen-containing compound), GO:1902531 (regulation of intracellular signal transduction), GO:0071363 (cellular response to growth factor stimulus), GO:1901655 (cellular response to ketone), GO:0043408 (regulation of MAPK cascade), GO:0042981 (regulation of apoptotic process), GO:0071548 (response to dexamethasone), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0071375 (cellular response to peptide hormone stimulus), GO:0031960 (response to corticosteroid), GO:0032868 (response to insulin), GO:0071392 (cellular response to estradiol stimulus), GO:2000345 (regulation of hepatocyte proliferation), GO:0043066 (negative regulation of apoptotic process), GO:0010976 (positive regulation of neuron projection development), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0071364 (cellular response to epidermal growth factor stimulus), GO:1901653 (cellular response to peptide), GO:0036294 (cellular response to decreased oxygen levels), GO:1902170 (cellular response to reactive nitrogen species), GO:0071383 (cellular response to steroid hormone stimulus), GO:0043410 (positive regulation of MAPK cascade), GO:0071732 (cellular response to nitric oxide), GO:0033574 (response to testosterone), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0032869 (cellular response to insulin stimulus), GO:1904036 (negative regulation of epithelial cell apoptotic process), GO:0051384 (response to glucocorticoid), GO:0010660 (regulation of muscle cell apoptotic process), GO:0071384 (cellular response to corticosteroid stimulus), GO:0071549 (cellular response to dexamethasone stimulus), GO:1904035 (regulation of epithelial cell apoptotic process), GO:0010656 (negative regulation of muscle cell apoptotic process), GO:0010975 (regulation of neuron projection development), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0010662 (regulation of striated muscle cell apoptotic process), GO:0071385 (cellular response to glucocorticoid stimulus), GO:0010664 (negative regulation of striated muscle cell apoptotic process), GO:0010667 (negative regulation of cardiac muscle cell apoptotic process), GO:0010665 (regulation of cardiac muscle cell apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0098797 (plasma membrane protein complex), GO:0098857 (membrane microdomain), GO:0005886 (plasma membrane), GO:0045121 (membrane raft)