lokahq/bioreason-rl huggingface dataset:
Protein: ATP-binding cassette, sub-family B (MDR/TAP), member 4 isoform 2 (A0A8N1TR42)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR003593: AAA+ ATPase domain (domain) [424-610]
- IPR011527: ABC transporter type 1, transmembrane domain (domain) [56-362]
- IPR039421: Type 1 protein exporter (family) [14-635]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [387-635]
- IPR017871: ABC transporter-like, conserved site (conserved_site) [536-550]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [397-633]
- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [43-636]
Sequence:
MGKKSKLKVSSDKKEENGDVSGEKNGKEEKEEKEKLEMVGPIELFRYADSIDILLMMLGLIMSMANGAVLPLMVIVFGDMTDSFVDDTLLDNLKNITLPPNFTFPETSNITLGEKMTTHAIYYSIMGFVVLVAAYMQVAFWTLAAGRQVKKLRKIFFHSIMKQEIGWFDVNETGQLNTRLTDDVYKINEGIGDKLGMLIQNLTTFIVGIIIGFAKGWKLTLVILAVSPLLGISAAVIGKVMTTFTSKEQTAYAKAGAVAEEVLSSIRTVFAFGGQKKEIKRYHKNLEDAKNVGVRKAITVNIAMGFTFFMIYMSYALAFWYGSTLILGGEYTIGMLLTIFFAVLIGAFGLGQTSPNIQTFSSARGAAHKVFQIIDHEPKINSFSEEGYKLDVVKGNIEFKNIHFRYPSRDDVKVLNGMNLKVMSGQTIALVGSSGCGKSTTIQLLQRFYDPQEGSVSIDGHDIRSLNVRGLRELIGVVSQEPVLFATTIAENIRYGRQDVTQDEIEQAAREANAYNFIMKLPDKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRLGRTTIVVAHRLSTIRNADVIAGFQNGEIVELGTHDELMERKGIYHSLVNMQVRNPLFRHESFAASTL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0140318 (protein transporter activity), GO:0008320 (protein transmembrane transporter activity), GO:0022884 (macromolecule transmembrane transporter activity), GO:0015562 (efflux transmembrane transporter activity), GO:0015450 (protein-transporting ATPase activity), GO:0140359 (ABC-type transporter activity), GO:0019534 (toxin transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0009636 (response to toxic substance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Cardiotrophin-like cytokine factor 1 (A0A8N7T7F8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted
InterPro domains:
- IPR010681: Plethodontid receptivity factor PRF/cardiotrophin-like (family) [2-379]
- IPR009079: Four-helical cytokine-like, core (homologous_superfamily) [25-378]
Sequence:
MCPWKVGQVAVLLLLAVMVGNAQVLDRTLILSNERSSIERTYELTKYLDHQLKEIRDTYLSYLGPPFSDPGFSPPRPNSSSLSVPSAATRVDLWRGLENGARLAQNQHAYSILLCAVRELARSTLCPYLQSSLLHFCSGLSGLLGSISGLMNALGYTNLPSSAGYATPAQGYAPAMSSQFQGVSENSPAPLRSYVPRNQGAKTVSGVREGTTRADLKRDREKERAERGRRGRRKEGESWVAKEEGEKEEGMERWGKRRRLLSMDEEKTIKLNNMNYTSLKFGDGYRKQPLLFSTPSLHPRRSVRSIPSSHSGLSPLSLLYQYGGPVSEVHTLLAAPVLSSHPTANDFSRKVEGFWVLRELQSWLWRSAKDFTRLKKRLRV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0005126 (cytokine receptor binding), GO:0048018 (receptor ligand activity), GO:0005125 (cytokine activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0050793 (regulation of developmental process), GO:0051094 (positive regulation of developmental process), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0032101 (regulation of response to external stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0051130 (positive regulation of cellular component organization), GO:0070570 (regulation of neuron projection regeneration), GO:0051128 (regulation of cellular component organization), GO:1903036 (positive regulation of response to wounding), GO:0080134 (regulation of response to stress), GO:0070572 (positive regulation of neuron projection regeneration), GO:0080135 (regulation of cellular response to stress), GO:0048680 (positive regulation of axon regeneration), GO:0048679 (regulation of axon regeneration), GO:0031344 (regulation of cell projection organization), GO:1903034 (regulation of response to wounding), GO:0031346 (positive regulation of cell projection organization), GO:0010976 (positive regulation of neuron projection development), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Nuclear factor, interleukin 3 regulated, member 5 (A0A8M1NV59)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR047106: Nuclear factor interleukin-3-regulated protein-like , bZIP domain (domain) [63-122]
- IPR004827: Basic-leucine zipper domain (domain) [62-128]
- IPR047229: Nuclear factor interleukin-3-regulated protein-like (family) [4-557]
- IPR046347: Basic-leucine zipper domain superfamily (homologous_superfamily) [61-118]
Sequence:
MESINLPTQNSGSSLETLETFSNYNESLPSPQMSSPPRQGRLIKPKPNSSCRRKREFISDEKKDASYWEKRRKNNEAAKRSREKRRLNDMVLENRVIALNDENVRLKTELLQLKLRFGLISSASYMEKTQQISNGAEAAANGANGSGATSGNPYFSSSGYSSASQVMMNSDSSEAEQSTRTERHTMLPKYSPRGSLSDMSDGSSRDSPEPINFDIKHESSGMDINRLEASVLNGMFNGHQSLGRLESNQPQEMEQQESVSNPAPPSATPQRSVILFRSGSSSYPVESQRVEDVDQQEASQTQQNGQITHFNQTGCNLPLRHDGLETLSEVAQQLARRSVDSPSYEFTNGKADAGENRRFVIQQQDLTVQGQCRSQVQDSTPNSFAPDLLNEAGKALVYQRTNPYLGTLNEEPPVLTYEGCTRADGFYQEHSSSGKDSSSSDGDPRSSDKEASTDDESPSSSSSDIGGYHATHQSASSPTMVTSDAYQYGDNQGEMKGTALPHKLRLKYRALSNGGSQDVQATTAAMSPESALPQHPYLALAQVNQQQGSSFGNKEGESETADELCTQRSPSRDKDMGWKESGKRSSGGRGNRNKKRD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048511 (rhythmic process), GO:0050789 (regulation of biological process), GO:0050794 (regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0007623 (circadian rhythm), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0032922 (circadian regulation of gene expression), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Tropomyosin alpha-3 chain isoform X5 (A0A8M2B6C5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton
InterPro domains:
- IPR000533: Tropomyosin (family) [8-247]
Sequence:
MAGSNSIDAVKRKIKVLQQQADEAEERAEILQRQVEEEKRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIVEGELERTEERAELAESHVKQMEEELRALDQTLKTLQASEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDMTSI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0051015 (actin filament binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0009653 (anatomical structure morphogenesis), GO:0030029 (actin filament-based process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0032989 (cellular component morphogenesis), GO:0016043 (cellular component organization), GO:0061061 (muscle structure development), GO:0044085 (cellular component biogenesis), GO:0030036 (actin cytoskeleton organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0022607 (cellular component assembly), GO:0042692 (muscle cell differentiation), GO:0006996 (organelle organization), GO:0030239 (myofibril assembly), GO:0031032 (actomyosin structure organization), GO:0055001 (muscle cell development), GO:0097435 (supramolecular fiber organization), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0014866 (skeletal myofibril assembly), GO:0051146 (striated muscle cell differentiation), GO:0055002 (striated muscle cell development), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030017 (sarcomere), GO:0005737 (cytoplasm), GO:0036379 (myofilament), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0005865 (striated muscle thin filament), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)
Protein: von Willebrand factor A domain-containing protein 2 (A0A8M9Q0S3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR000742: EGF-like domain (domain) [295-748]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [38-715]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [259-740]
- IPR002035: von Willebrand factor, type A (domain) [49-707]
- IPR050525: Extracellular Matrix Assembly and Organization (family) [23-330]
- IPR001881: EGF-like calcium-binding domain (domain) [296-748]
Sequence:
MSSSSRQNLFFMLLFGQVWSIFSVQEIQTDLDTIMKINAAGEMMQCSAAMDILFVMDSSYSVGKGGFERSRHYMLKLCEALDVRQDKVRVGVVQFGSTPKLEVSLDSYKTKEELKKKLKKIHYRGGSTQTGLALKFVLRKGFSGGRNSSVPRVVVLLSDGKSQGAVQLPASELKLSGVLLFAVGIRYPRWDELRELASGPSDSHVFFAEHFSDAVNGLFTSLTTSSVCMSIPSGCKVESYPCVQKTLETVKQLQGNFVCWKGSKGYSAYTSLCPHYRYNKVYRQHPAVCHRTICPDPCDSQPCQNGGTCVSEGLDKYRCECPAGYANDPNCAPILSFDCSVDVLFLLEGSSALTLEGFLRFKSFLKRFMQAVLSSDTPVKMGLAQYGSDVKIEARIGEHRDPVKLIQAVEGLQYRGGQTKTGNALRYITRHGFQSTPVFADVQDDLPRVVVLLTGTPSADHVVEPAKYARDREIFIIGVAPEGMRAEINNITGNPQRTIMYQSPDRLSSKIPELRAKICSVDNQGCLGQALDLVFVLDASSGVGKENFIHFQDFVRSTSVQFDINRDVAQVGLVVYGRRPVTVFDLDKYNSGSAVLRAVGDAAFLGGKASVGSALLHVLSQSLTVGKGARPGVNKAVVVLTDGTGVEDAAVPAQKIRDSGVSIFLIGVGDIQQELLLRISGSEDHMITVPSYDDLKYSEDVLVQMVCSDVKKPVNLCSPNPCMNDGICVMLNGSYRCECRGWKGPHCETRSREQPSRGDLPKPAGLRRRQPKTEKELLQRYKEQRRRHTSKTQIR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0001894 (tissue homeostasis), GO:0060249 (anatomical structure homeostasis), GO:0010669 (epithelial structure maintenance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0005576 (extracellular region), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix), GO:0005604 (basement membrane)
Protein: Actin filament-associated protein 1-like 2 isoform X1 (A0A8M9Q402)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR030113: Actin-filament associated protein (family) [1-889]
- IPR001849: Pleckstrin homology domain (domain) [206-472]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [183-474]
Sequence:
MDKHKVLEQLLEQLQKFLKILDVEKLSGNAKVQKGLLMELLQSYKSSNAGGDEEYIYMNKVIVTCQTQDKTNRDHRPEANGDPSKHISVKNPPEPPPPRPCNTGREPFPLPPAPAPASMENESYYEDPQPYDPISINDFGCFAVITGLRKRVEASNGVVYAVITREDTEQLSSSYESYDEEEVTKGKSTAQHQWPSPEASIELMKDARICAFLWRKKWLGQWAKQLCVVREHRLLCYKSSKDQTPLLDISLLGCSVVYKEKQTKRKEHKLKISPLGAEAIVLGLQSKEQAEQWLKVIQEISPKNTTGSDVTDSPTLICTKGEQSERYSVASESGSSTDSHAENMENKDVKKKYGKFSNLMNIGKKKVCSLESPEKSVDTSGYLNVLVNTQWRSRWCSVKDRQLWIYSDKSKGKVAQQPLSLEGCMVLPDPSPEHLYSFRIQMDGEELAILEAKSSADMGHWLGLILSQTGTKTDPEDLSYDYVNSERISSIVNAAKTSMYLMQRRYSEPNTYTDSPPSDPQTCDDIYDDVPSTENEQEEVQEVQNGSEEGTVNAEEENGKDRVYLDLIPLRSFLHTSSGRVSPQTSSTTQTEISPSTTPHVDDQLKEPVYESSLPTSTENEVPPPVAPRVDTDPSPVPNLHVQPQKISFLGQEIQKKASSTSPLPKTQSLPQTSAQTPQSPPTSRARAASTDRLLDRLKFSPAAGPGSVEVKLGKNRTEADVRRYTDDRDRLEREREEVKNTLATLRKDRREVKDELSSCQDPIRQASLEARLKQMEETCREAERRRVEVELSLMEVKENLRKVESGPFTLGTTVDSSLLEISVHKPAAVSSPAPNTPNNTNINTPACTNNGDSPVNSATALKNRPPSVMAASKGNVLQKAKEWEKKTTT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding), GO:0017124 (SH3 domain binding), GO:0042169 (SH2 domain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0060900 (embryonic camera-type eye formation), GO:0009887 (animal organ morphogenesis), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:0048568 (embryonic organ development), GO:0048562 (embryonic organ morphogenesis), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0002072 (optic cup morphogenesis involved in camera-type eye development), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0016331 (morphogenesis of embryonic epithelium), GO:0002011 (morphogenesis of an epithelial sheet), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0048048 (embryonic eye morphogenesis), GO:0031076 (embryonic camera-type eye development), GO:0061386 (closure of optic fissure), GO:0150063 (visual system development), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0048596 (embryonic camera-type eye morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: PRKR-like endoplasmic reticulum kinase (A0A8M2B3B8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single- pass type I membrane protein
InterPro domains:
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [921-933]
- IPR000719: Protein kinase domain (domain) [612-1067]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [93-277]
- IPR011047: Quinoprotein alcohol dehydrogenase-like superfamily (homologous_superfamily) [101-259]
- IPR017441: Protein kinase, ATP binding site (binding_site) [618-641]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [603-1081]
- IPR050339: Cell Cycle and Stress Response Kinase (family) [324-1081]
Sequence:
MERGFQFGNVCISLLLLLVLRTLTATLQTQSLSEREVEVAPTPNTEAAEHAAVMERPLDNVGGALGIGEVTVEDDDYGSTGDSDEPSGDTDANFHKHRRALVIISTLDGRIAALDPLNQGRKQWDLDVGSGCLVSSSLSKPEIFGNKMFIPSLDGALFQWNRDRESMEAVSFSVESLLDSSYRIGEDTVLVGGKSLTTYGLGAYSGKLKYICSAVGCSRWGDEEGEPEDVLLLQRTQKTVRAVRPRNGFEKWNFSVGNFELKFVPEVQSKLNFLEGEAPSGETWREVRREAQRVIQEETDAQTKNHAKMHPNSAHTQVEGLDLVIKVSVPDWKVMAFSTKPEGQLIWEHQFCTPIASAWLVGGGKVTPISLFDDTSYNSQTETETQEDDDIMEEARGATESSVYLGMFQGQLYLQSSVRISEKFPSKSKALNGWGGDTDMMPPPTVKWKPLIHSPSRTPVLVGSEEFDKCLNNDKFSHEEYSNGALSILQYPYDNGYYFPYSPRYRNRRDETAVSVLLKKDGEGSQVRRKDPVLLLPWWKEILGTIFFCIAATTYIVRKFFHPPTTYSRQRKESETQCQTDTKFEADVTEPKEVVVTDMRPCEYVSRYLTDFEPVQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIIRYFNAWQESPPQGWQEDMDKRWLKDASTADWLLSSPEHMEAFSVKVPVATPSPVDSSCMCAAGGDTSVCVGDQVCVEGLGPDSMMSERDSQADPDAIMEVSDSPHSFELCPPRTVAHGDCTSSSFDIVFEDSGCEHQDNDSDLSGSTPVPPVCLSQSGSKPQRSTSTGPPISLPSRPTTLSLAPSTPCPAVRPLLTPKVYLYIQMQLCRKENLKDWMAQRCLPELREHTQCLDIFLQIAEAVDFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQEEDDEELSTLTPMPIYARHTGQVGTKLYMSPEQLSGNSYSHKVDIYSLGLILFELLCPFRTQMERVRTLTEVRALQFPAAFCKANILEAQMVRCMLSRVPAERPEASEITEAPLFQELEVPCRIRQRTRTYSASSAGRPSRQISSSN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0001666 (response to hypoxia), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0034976 (response to endoplasmic reticulum stress), GO:0036293 (response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: folate gamma-glutamyl hydrolase (A0A8M9PNR0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space
InterPro domains:
Sequence:
MIHIFLLCLFTVANAVSIYNFGPLIKTNERPIIGVLAQDVFDPKPDRNSYIAASYVKFLESAGARVVPVMINKSEDEYSRLFKSINGVLFPGGGVSLESSGYSKAAGIFYRLALEANSNGDYFPVWGTCLGFELLTLLTSGELLLSHTNTSGIALPLDFTEDVKGSRLFKEFPEELMKSLATEPLTENSHQWSITTEQHNMMFYKVSMINLTMSPPLPSSPSPCV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008242 (omega peptidase activity), GO:0008234 (cysteine-type peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006767 (water-soluble vitamin metabolic process), GO:0033013 (tetrapyrrole metabolic process), GO:0006778 (porphyrin-containing compound metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Huntingtin-interacting protein 1 isoform X3 (A0A8M3ASL4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR011417: AP180 N-terminal homology (ANTH) domain (domain) [40-304]
- IPR002558: I/LWEQ domain (domain) [759-1000]
- IPR013809: ENTH domain (domain) [32-160]
- IPR008942: ENTH/VHS (homologous_superfamily) [27-155]
- IPR032422: Huntingtin-interacting protein 1, clathrin-binding domain (domain) [483-594]
- IPR030224: Sla2 family (family) [25-531]
- IPR035964: I/LWEQ domain superfamily (homologous_superfamily) [762-952]
Sequence:
MDRVKSSMQQVPNPIPKVLSRRAGGANSLEVEKENFERNQAVSINKAINTQEVAVKEKHARTCILGTHHEKGAHTFWLAVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVIKDSMRHKADLNDMSRMWGHLSEGYGKLCSIYLKLLITKMEFHIKNPRFPGNLQMSNRQLDEAGENDVNNFFQLTVEMFDYLECELNLFLGVFSSLDMSRSVSVTAAGQCRLAPLIQVILDSSHLYDYTVKLLFKLHSCLPADTLQGHRDRFQEQFKKLKSLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPESEHVVETEDLVDTDIPPLTGTGDSKFDDLFGTSAATDPFNFNSQNGMRKDDKDRLIEQLTAELQALKEELESFRLESGRLCQALRGRVNELEAELAEQTHLKQQALGESEFLRAELDDLRRVKEDTEKEQRSLSEIERKAQANEQRYTKLKEKYTELVQSHADLLRKNAEVTRQMTVARAAQDEVENVKKEMQDRLKVAQDSASQQSNEQLGTQLSALVAEKAGLVETVSRKEVELSGLGAELERLQSSLTNERESGVKAAEALQNQLNEKESREQALESELVSLRWASLRAALEEAGKIVQDSLNQLEDPAHISCTSSADYLVSRCQVALDCVERLRSSRDGFVSDNTDVSGLVRAVTQFAHLVGDVIVQGSATSHMVPVEQADALADSVKACGAEALTLLCQLKEQESMGAADCSRLRTALDSVKALGEKLRPRGLELQQGELGDLVEQEMAATSAAVESAAARIEEMLNKSRAVDTGIKMEVNERILASCTDLMQAIRVLVLSSKDLQRDIVESGRGAASMKEFYAKNSRWTEGLISASKAVGWGATMLVDAADQVVQGKGKFEELMVCSHEIAASTAQLVAASKVKAEKGSSNLSRLQQASKGVTQATAGVVASTKSGKSQIEDTETMDFSAMTLTQIKRQEMDAQVLVLELETRLQKERERLGELRKKHYELAGVAEGWGGEEEGTG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0051707 (response to other organism), GO:0007275 (multicellular organism development), GO:0009607 (response to biotic stimulus), GO:0009790 (embryo development), GO:0009620 (response to fungus), GO:0043207 (response to external biotic stimulus), GO:0009792 (embryo development ending in birth or egg hatching), GO:0001878 (response to yeast), GO:0043009 (chordate embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005769 (early endosome), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)