Protein: Histone deacetylase (A6KID6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus
InterPro domains:
- IPR003084: Class I/II Histone deacetylase HDAC (family) [7-458]
- IPR023696: Ureohydrolase domain superfamily (homologous_superfamily) [10-374]
- IPR000286: Histone deacetylase HDAC (family) [138-265]
- IPR037138: Histone deacetylase domain superfamily (homologous_superfamily) [8-381]
- IPR023801: Histone deacetylase domain (domain) [29-319]
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAVLELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKEAEDKRTDVKEEDKSKDNSGEKTDTKGAKSEQLNNP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0003682 (chromatin binding), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:1990841 (promoter-specific chromatin binding), GO:0031072 (heat shock protein binding), GO:0019213 (deacetylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:2000241 (regulation of reproductive process), GO:0051240 (positive regulation of multicellular organismal process), GO:0006807 (nitrogen compound metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:2000243 (positive regulation of reproductive process), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0009628 (response to abiotic stimulus), GO:0019222 (regulation of metabolic process), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:0048522 (positive regulation of cellular process), GO:0061000 (negative regulation of dendritic spine development), GO:0009266 (response to temperature stimulus), GO:0043207 (response to external biotic stimulus), GO:0051129 (negative regulation of cellular component organization), GO:0009410 (response to xenobiotic stimulus), GO:0070482 (response to oxygen levels), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0051098 (regulation of binding), GO:0010718 (positive regulation of epithelial to mesenchymal transition), GO:0001817 (regulation of cytokine production), GO:0009408 (response to heat), GO:0010035 (response to inorganic substance), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0001819 (positive regulation of cytokine production), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0035094 (response to nicotine), GO:1902074 (response to salt), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0060998 (regulation of dendritic spine development), GO:0045597 (positive regulation of cell differentiation), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1902435 (regulation of male mating behavior), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0006979 (response to oxidative stress), GO:0044092 (negative regulation of molecular function), GO:0019538 (protein metabolic process), GO:0055093 (response to hyperoxia), GO:1901700 (response to oxygen-containing compound), GO:0030534 (adult behavior), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0003012 (muscle system process), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:1901698 (response to nitrogen compound), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0009617 (response to bacterium), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0048520 (positive regulation of behavior), GO:0050795 (regulation of behavior), GO:0034599 (cellular response to oxidative stress), GO:1903555 (regulation of tumor necrosis factor superfamily cytokine production), GO:0097305 (response to alcohol), GO:0014896 (muscle hypertrophy), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051100 (negative regulation of binding), GO:0051246 (regulation of protein metabolic process), GO:0002237 (response to molecule of bacterial origin), GO:0050769 (positive regulation of neurogenesis), GO:0071869 (response to catecholamine), GO:0010468 (regulation of gene expression), GO:0043412 (macromolecule modification), GO:0032732 (positive regulation of interleukin-1 production), GO:0034605 (cellular response to heat), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0071417 (cellular response to organonitrogen compound), GO:0071559 (response to transforming growth factor beta), GO:0032496 (response to lipopolysaccharide), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0031344 (regulation of cell projection organization), GO:0071310 (cellular response to organic substance), GO:0036296 (response to increased oxygen levels), GO:0062197 (cellular response to chemical stress), GO:0060284 (regulation of cell development), GO:0051248 (negative regulation of protein metabolic process), GO:0010720 (positive regulation of cell development), GO:1903557 (positive regulation of tumor necrosis factor superfamily cytokine production), GO:1901699 (cellular response to nitrogen compound), GO:0010628 (positive regulation of gene expression), GO:0051960 (regulation of nervous system development), GO:0045685 (regulation of glial cell differentiation), GO:0032652 (regulation of interleukin-1 production), GO:0036211 (protein modification process), GO:0042220 (response to cocaine), GO:0010243 (response to organonitrogen compound), GO:0033993 (response to lipid), GO:0031326 (regulation of cellular biosynthetic process), GO:0051101 (regulation of DNA binding), GO:0048149 (behavioral response to ethanol), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0014070 (response to organic cyclic compound), GO:0042542 (response to hydrogen peroxide), GO:0031345 (negative regulation of cell projection organization), GO:0051253 (negative regulation of RNA metabolic process), GO:0010717 (regulation of epithelial to mesenchymal transition), GO:0000302 (response to reactive oxygen species), GO:0071363 (cellular response to growth factor stimulus), GO:0051174 (regulation of phosphorus metabolic process), GO:0032526 (response to retinoic acid), GO:0043392 (negative regulation of DNA binding), GO:0045471 (response to ethanol), GO:0031400 (negative regulation of protein modification process), GO:0098732 (macromolecule deacylation), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0035601 (protein deacylation), GO:0071867 (response to monoamine), GO:0048713 (regulation of oligodendrocyte differentiation), GO:0010977 (negative regulation of neuron projection development), GO:0050767 (regulation of neurogenesis), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0034614 (cellular response to reactive oxygen species), GO:0031401 (positive regulation of protein modification process), GO:0032760 (positive regulation of tumor necrosis factor production), GO:0071870 (cellular response to catecholamine stimulus), GO:0071560 (cellular response to transforming growth factor beta stimulus), GO:1903350 (response to dopamine), GO:0043279 (response to alkaloid), GO:0016570 (histone modification), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0031399 (regulation of protein modification process), GO:0071300 (cellular response to retinoic acid), GO:0014075 (response to amine), GO:0071868 (cellular response to monoamine stimulus), GO:0006355 (regulation of DNA-templated transcription), GO:0071407 (cellular response to organic cyclic compound), GO:0019220 (regulation of phosphate metabolic process), GO:0071396 (cellular response to lipid), GO:0014015 (positive regulation of gliogenesis), GO:0014897 (striated muscle hypertrophy), GO:0045687 (positive regulation of glial cell differentiation), GO:0032680 (regulation of tumor necrosis factor production), GO:0014074 (response to purine-containing compound), GO:0070301 (cellular response to hydrogen peroxide), GO:0001932 (regulation of protein phosphorylation), GO:0003300 (cardiac muscle hypertrophy), GO:0048714 (positive regulation of oligodendrocyte differentiation), GO:0031000 (response to caffeine), GO:0006476 (protein deacetylation), GO:1901984 (negative regulation of protein acetylation), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903351 (cellular response to dopamine), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0001934 (positive regulation of protein phosphorylation), GO:0001975 (response to amphetamine), GO:0010975 (regulation of neuron projection development), GO:0042325 (regulation of phosphorylation), GO:0014013 (regulation of gliogenesis), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0016575 (histone deacetylation), GO:1901983 (regulation of protein acetylation), GO:0042509 (regulation of tyrosine phosphorylation of STAT protein), GO:0050730 (regulation of peptidyl-tyrosine phosphorylation), GO:2000757 (negative regulation of peptidyl-lysine acetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:0005694 (chromosome)