Protein: Protein disulfide-isomerase (A0A8I5QKQ5)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum lumen. Melanosome
InterPro domains:
- IPR005792: Protein disulphide isomerase (family) [25-449]
- IPR041868: Protein disulfide-isomerase A3, first redox inactive TRX-like domain b (domain) [135-240]
- IPR017937: Thioredoxin, conserved site (conserved_site) [49-416]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [24-449]
- IPR005788: Protein disulfide-isomerase, thioredoxin-like domain (domain) [30-131]
- IPR013766: Thioredoxin domain (domain) [19-456]
Sequence:
MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGNMKVAVN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0097159 (organic cyclic compound binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0003676 (nucleic acid binding), GO:0003756 (protein disulfide isomerase activity), GO:0008233 (peptidase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016860 (intramolecular oxidoreductase activity), GO:0042802 (identical protein binding), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0015035 (protein-disulfide reductase activity), GO:0016298 (lipase activity), GO:0016864 (intramolecular oxidoreductase activity, transposing S-S bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0015036 (disulfide oxidoreductase activity), GO:0003723 (RNA binding), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity), GO:0008081 (phosphoric diester hydrolase activity), GO:0004620 (phospholipase activity), GO:0004629 (phospholipase C activity)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0019882 (antigen processing and presentation), GO:0006457 (protein folding), GO:0006458 ('de novo' protein folding), GO:0002504 (antigen processing and presentation of peptide or polysaccharide antigen via MHC class II), GO:0061077 (chaperone-mediated protein folding), GO:0019884 (antigen processing and presentation of exogenous antigen), GO:0048002 (antigen processing and presentation of peptide antigen), GO:0002495 (antigen processing and presentation of peptide antigen via MHC class II), GO:0051084 ('de novo' post-translational protein folding), GO:0002478 (antigen processing and presentation of exogenous peptide antigen), GO:0051085 (chaperone cofactor-dependent protein refolding), GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)