Protein: Carbamyl phosphatate synthetase 2 (Mapped), isoform CRA_e (A6HA80)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR016185: Pre-ATP-grasp domain superfamily (homologous_superfamily) [472-1127]
- IPR005483: Carbamoyl phosphate synthase, CPSase domain (domain) [484-858]
- IPR006130: Aspartate/ornithine carbamoyltransferase (family) [2048-2289]
- IPR006680: Amidohydrolase-related (domain) [1543-1601]
- IPR002474: Carbamoyl-phosphate synthase small subunit, N-terminal domain (domain) [79-218]
- IPR005480: Carbamoyl-phosphate synthetase, large subunit oligomerisation domain (domain) [877-1000]
- IPR006275: Carbamoyl-phosphate synthase, large subunit (family) [472-1519]
- IPR032466: Metal-dependent hydrolase (homologous_superfamily) [1545-1822]
- IPR005479: Carbamoyl phosphate synthase, ATP-binding domain (domain) [593-1327]
- IPR006131: Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain (domain) [2151-2299]
- IPR006274: Carbamoyl-phosphate synthase, small subunit (family) [79-440]
- IPR006132: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding (domain) [2003-2144]
- IPR002082: Aspartate carbamoyltransferase (family) [2002-2303]
- IPR011059: Metal-dependent hydrolase, composite domain superfamily (homologous_superfamily) [1813-1892]
- IPR011761: ATP-grasp fold (domain) [598-1322]
- IPR017926: Glutamine amidotransferase (domain) [259-434]
- IPR002195: Dihydroorotase, conserved site (conserved_site) [1548-1774]
- IPR011607: Methylglyoxal synthase-like domain (domain) [1387-1541]
- IPR013815: ATP-grasp fold, subdomain 1 (homologous_superfamily) [1139-1208]
- IPR029062: Class I glutamine amidotransferase-like (homologous_superfamily) [228-439]
Sequence:
MVPPLTCMVPPLTLPAACAVAVVLQLTTLRAPACRSRLLSSAPRSEPRGPTPARGVCLVPVGLAAPPASRCSPCLSSDPMAALVLEDGSVLQGRPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYGIPSDEEDEFGLSKWFESSEIHVAGLVVGECCPTPSHWSATCTLHEWLQQHGIPGLQGVDTRELTKKLREQGSLLGKLVQKGTEPSALPFVDPNARPLAPEVSIKTPRVFNAGGAPRIFAVDCGLKYNQIRCLCQLGAEVTVVPWNHELDSRKYDGLFLSNGPGDPASYPGVVSTLNRVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGTGRCFLTSQNHGFAVDADSLPAGWAPLFTNANDCSNEGIVHDNLPFFSVQFHPEHRAGPSDMELLFDVFLETVRDTVAGNAEGRTVRERLAQRLCPPELPIPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGILLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASTKEELSALVAPAFAHTSQVLIDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRRTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVTGGTAAFEPSLDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVSDVELETPTDKRIFVVAAALWAGYSVERLYELTRIDCWFLHRMKRIVTHAKLLEQHRGRPLPQDLLHQAKCLGFSDKQIALAVLSTELVVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGNTHDLDFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVACDGIVSAIAISEHVENAGVHSGDATLVTPPQDITPKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRIIMGEKVESVGLMTGSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILDQLAENHFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGVTMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFTLFLGASSENAGTLGAVAGSAAGLKLYLNETFSELRLDSVAQWMEHFETWPSHLPIVAHAERQSVAAVLMVAQLTRRSVHICHVARKEEILLIKTAKAQGLPVTCEVAPHHLFLNREDLERLGPGKGEVRPELGSREDMEALWENMAVIDCFASDHAPHTLEEKCGPKPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPLQEDTYVEVDLEHEWTVPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQPPPPTPTTTEITTTPERPRRVIPGLPDGRFHLPPRIHRASDPGLPAEEPKEKPPRKVAESELIGTPDGPCYPVPPVPRQASPQNLGSSGLLHPQMSPLLHSLVGQHILSVKQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSLRYVAPPSLRMPSSVWDFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSSQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLGRF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0016740 (transferase activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0042802 (identical protein binding), GO:0016879 (ligase activity, forming carbon-nitrogen bonds), GO:0016884 (carbon-nitrogen ligase activity, with glutamine as amido-N-donor), GO:0016812 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides), GO:0016743 (carboxyl- or carbamoyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0022414 (reproductive process), GO:0032501 (multicellular organismal process), GO:0000003 (reproduction), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0065008 (regulation of biological quality), GO:0044706 (multi-multicellular organism process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0009719 (response to endogenous stimulus), GO:0044703 (multi-organism reproductive process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009410 (response to xenobiotic stimulus), GO:0048731 (system development), GO:0019637 (organophosphate metabolic process), GO:0048513 (animal organ development), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006805 (xenobiotic metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0009991 (response to extracellular stimulus), GO:1901360 (organic cyclic compound metabolic process), GO:0050878 (regulation of body fluid levels), GO:0007565 (female pregnancy), GO:0044283 (small molecule biosynthetic process), GO:0042594 (response to starvation), GO:0006139 (nucleobase-containing compound metabolic process), GO:1901698 (response to nitrogen compound), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0006810 (transport), GO:0070887 (cellular response to chemical stimulus), GO:0031099 (regeneration), GO:1901652 (response to peptide), GO:0097305 (response to alcohol), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0071466 (cellular response to xenobiotic stimulus), GO:0009112 (nucleobase metabolic process), GO:0070849 (response to epidermal growth factor), GO:1901654 (response to ketone), GO:0043436 (oxoacid metabolic process), GO:0008652 (amino acid biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0048732 (gland development), GO:0048545 (response to steroid hormone), GO:0046903 (secretion), GO:0006796 (phosphate-containing compound metabolic process), GO:0061008 (hepaticobiliary system development), GO:1901605 (alpha-amino acid metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0031100 (animal organ regeneration), GO:0043434 (response to peptide hormone), GO:0010243 (response to organonitrogen compound), GO:0007589 (body fluid secretion), GO:0016053 (organic acid biosynthetic process), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0018130 (heterocycle biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0072359 (circulatory system development), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0014070 (response to organic cyclic compound), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0072527 (pyrimidine-containing compound metabolic process), GO:0071363 (cellular response to growth factor stimulus), GO:0007507 (heart development), GO:0030879 (mammary gland development), GO:0009141 (nucleoside triphosphate metabolic process), GO:0043279 (response to alkaloid), GO:0009117 (nucleotide metabolic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0051414 (response to cortisol), GO:0031960 (response to corticosteroid), GO:0032868 (response to insulin), GO:0009064 (glutamine family amino acid metabolic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0014075 (response to amine), GO:0046394 (carboxylic acid biosynthetic process), GO:0006206 (pyrimidine nucleobase metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0006220 (pyrimidine nucleotide metabolic process), GO:0001889 (liver development), GO:0046112 (nucleobase biosynthetic process), GO:0046390 (ribose phosphate biosynthetic process), GO:0007595 (lactation), GO:0014074 (response to purine-containing compound), GO:0033574 (response to testosterone), GO:0072528 (pyrimidine-containing compound biosynthetic process), GO:0071364 (cellular response to epidermal growth factor stimulus), GO:0009142 (nucleoside triphosphate biosynthetic process), GO:0009260 (ribonucleotide biosynthetic process), GO:0019856 (pyrimidine nucleobase biosynthetic process), GO:0009199 (ribonucleoside triphosphate metabolic process), GO:0009147 (pyrimidine nucleoside triphosphate metabolic process), GO:0051384 (response to glucocorticoid), GO:0031000 (response to caffeine), GO:0009218 (pyrimidine ribonucleotide metabolic process), GO:0006541 (glutamine metabolic process), GO:0009165 (nucleotide biosynthetic process), GO:0006221 (pyrimidine nucleotide biosynthetic process), GO:0009220 (pyrimidine ribonucleotide biosynthetic process), GO:0006207 ('de novo' pyrimidine nucleobase biosynthetic process), GO:0009148 (pyrimidine nucleoside triphosphate biosynthetic process), GO:0009201 (ribonucleoside triphosphate biosynthetic process), GO:0009208 (pyrimidine ribonucleoside triphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0150034 (distal axon), GO:0044306 (neuron projection terminus), GO:0042995 (cell projection), GO:0030054 (cell junction), GO:0044297 (cell body), GO:0005829 (cytosol), GO:0098793 (presynapse), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0043679 (axon terminus), GO:0045202 (synapse), GO:0043195 (terminal bouton), GO:0043005 (neuron projection), GO:0030424 (axon)