Protein: Ras-related protein Rab-7a (A0A6Q8PGE6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Melanosome membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein
InterPro domains:
- IPR001806: Small GTPase (family) [1-183]
- IPR005225: Small GTP-binding domain (domain) [2-145]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-166]
Sequence:
MNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKASAESCSC
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0097367 (carbohydrate derivative binding), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0044877 (protein-containing complex binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0019003 (GDP binding), GO:0032555 (purine ribonucleotide binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0017076 (purine nucleotide binding), GO:0016462 (pyrophosphatase activity), GO:0005525 (GTP binding), GO:0019001 (guanyl nucleotide binding), GO:0032561 (guanyl ribonucleotide binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0048519 (negative regulation of biological process), GO:0016032 (viral process), GO:0009605 (response to external stimulus), GO:0022406 (membrane docking), GO:0051641 (cellular localization), GO:0023057 (negative regulation of signaling), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051050 (positive regulation of transport), GO:0019725 (cellular homeostasis), GO:0019076 (viral release from host cell), GO:0009607 (response to biotic stimulus), GO:0006885 (regulation of pH), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0061919 (process utilizing autophagic mechanism), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0048524 (positive regulation of viral process), GO:0051051 (negative regulation of transport), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0044403 (biological process involved in symbiotic interaction), GO:0009056 (catabolic process), GO:0033036 (macromolecule localization), GO:0048878 (chemical homeostasis), GO:0044237 (cellular metabolic process), GO:0019058 (viral life cycle), GO:0009893 (positive regulation of metabolic process), GO:0044238 (primary metabolic process), GO:0050792 (regulation of viral process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0051047 (positive regulation of secretion), GO:0044085 (cellular component biogenesis), GO:0051129 (negative regulation of cellular component organization), GO:0043207 (response to external biotic stimulus), GO:0044248 (cellular catabolic process), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0060627 (regulation of vesicle-mediated transport), GO:0051668 (localization within membrane), GO:0044089 (positive regulation of cellular component biogenesis), GO:0045184 (establishment of protein localization), GO:0051048 (negative regulation of secretion), GO:0006914 (autophagy), GO:0044087 (regulation of cellular component biogenesis), GO:0051701 (biological process involved in interaction with host), GO:0009894 (regulation of catabolic process), GO:0055082 (intracellular chemical homeostasis), GO:0046907 (intracellular transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:1901575 (organic substance catabolic process), GO:1903531 (negative regulation of secretion by cell), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0050801 (monoatomic ion homeostasis), GO:0010648 (negative regulation of cell communication), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0051649 (establishment of localization in cell), GO:0030641 (regulation of cellular pH), GO:0043170 (macromolecule metabolic process), GO:0010646 (regulation of cell communication), GO:0009617 (response to bacterium), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0080090 (regulation of primary metabolic process), GO:0009896 (positive regulation of catabolic process), GO:1903532 (positive regulation of secretion by cell), GO:0071705 (nitrogen compound transport), GO:0051246 (regulation of protein metabolic process), GO:0098876 (vesicle-mediated transport to the plasma membrane), GO:0030163 (protein catabolic process), GO:0044000 (movement in host), GO:0071702 (organic substance transport), GO:0022607 (cellular component assembly), GO:0009057 (macromolecule catabolic process), GO:0006886 (intracellular protein transport), GO:0015031 (protein transport), GO:1901184 (regulation of ERBB signaling pathway), GO:0016482 (cytosolic transport), GO:0045920 (negative regulation of exocytosis), GO:0061024 (membrane organization), GO:1901185 (negative regulation of ERBB signaling pathway), GO:1901565 (organonitrogen compound catabolic process), GO:0042176 (regulation of protein catabolic process), GO:0051453 (regulation of intracellular pH), GO:0072594 (establishment of protein localization to organelle), GO:0017157 (regulation of exocytosis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0045921 (positive regulation of exocytosis), GO:0090150 (establishment of protein localization to membrane), GO:0016236 (macroautophagy), GO:0010639 (negative regulation of organelle organization), GO:0072657 (protein localization to membrane), GO:0055080 (monoatomic cation homeostasis), GO:0016197 (endosomal transport), GO:0051247 (positive regulation of protein metabolic process), GO:0033043 (regulation of organelle organization), GO:0045732 (positive regulation of protein catabolic process), GO:0051046 (regulation of secretion), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0007034 (vacuolar transport), GO:0006996 (organelle organization), GO:0098927 (vesicle-mediated transport between endosomal compartments), GO:0072666 (establishment of protein localization to vacuole), GO:0006909 (phagocytosis), GO:0016050 (vesicle organization), GO:1990778 (protein localization to cell periphery), GO:0008333 (endosome to lysosome transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0006605 (protein targeting), GO:0007041 (lysosomal transport), GO:0032456 (endocytic recycling), GO:0051452 (intracellular pH reduction), GO:0061025 (membrane fusion), GO:0090382 (phagosome maturation), GO:0070925 (organelle assembly), GO:0042058 (regulation of epidermal growth factor receptor signaling pathway), GO:0033365 (protein localization to organelle), GO:1905037 (autophagosome organization), GO:0061951 (establishment of protein localization to plasma membrane), GO:0099638 (endosome to plasma membrane protein transport), GO:0006897 (endocytosis), GO:0007033 (vacuole organization), GO:0006906 (vesicle fusion), GO:0072659 (protein localization to plasma membrane), GO:0045022 (early endosome to late endosome transport), GO:0042147 (retrograde transport, endosome to Golgi), GO:0035891 (exit from host cell), GO:0006623 (protein targeting to vacuole), GO:0048284 (organelle fusion), GO:0042059 (negative regulation of epidermal growth factor receptor signaling pathway), GO:0090383 (phagosome acidification), GO:0001845 (phagolysosome assembly), GO:0072665 (protein localization to vacuole), GO:0006622 (protein targeting to lysosome), GO:0090385 (phagosome-lysosome fusion), GO:0090174 (organelle membrane fusion), GO:0000045 (autophagosome assembly), GO:0080171 (lytic vacuole organization), GO:0061462 (protein localization to lysosome), GO:0007040 (lysosome organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005764 (lysosome)