lokahq/bioreason-rl huggingface dataset:
Protein: Tyrosinase (A6I5Y6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Melanosome membrane; Single-pass type I membrane protein
InterPro domains:
- IPR002227: Tyrosinase copper-binding domain (domain) [172-402]
- IPR050316: Tyrosinase and Hemocyanin (family) [61-467]
- IPR008922: Di-copper centre-containing domain superfamily (homologous_superfamily) [76-462]
Sequence:
MFLAVLYYLLWSFQTSAGHFPRDCASSKNLMAKECCPPWMGDGSPCGHLSGRGSCQDILLSNAPSGPQFPFKGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFGGPNCTEKRLLIRRNIFDLSASEKNKFFSYLTLAKHTISSVYVIPTGTYGQMNNGSTPMFKDINIYDLFVWMHYYVSRDTLLGGSEIWRDIDFAHEAPGFLPWHRLFLLLWEQEMQELTGDENFTIPYWDWRDAENCDICTDEYLGGRHPENPNLLSPASFFSSWEIICSRSEEYNSHQVLCDGTPEGPLLRNPGNHDKAKTPRLPSSADVEFCLSLTQYESGSMDRTANFSFRNTLEGFASPLTGIADSSQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLLEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQESDPGFYRNYIEPYLEQASRIWPWLLGAALVGAVVATALAGLSSRLCHQKKKQPQEERQPLLMDKDDYHSLLYQSHL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016716 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005507 (copper ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0043473 (pigmentation), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0009991 (response to extracellular stimulus), GO:1901700 (response to oxygen-containing compound), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0009314 (response to radiation), GO:0046683 (response to organophosphorus), GO:0009416 (response to light stimulus), GO:0051591 (response to cAMP), GO:0014070 (response to organic cyclic compound), GO:0010243 (response to organonitrogen compound), GO:0033273 (response to vitamin), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0033280 (response to vitamin D), GO:0014074 (response to purine-containing compound), GO:0009411 (response to UV)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Bone morphogenetic protein 15 (A6KPC2)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR029034: Cystine-knot cytokine (homologous_superfamily) [223-336]
- IPR001839: Transforming growth factor-beta, C-terminal (domain) [208-336]
- IPR017948: Transforming growth factor beta, conserved site (conserved_site) [253-268]
- IPR015615: Transforming growth factor-beta-related (family) [6-336]
Sequence:
MKQWPQGYPLRYMLKLYQRSADPHGHPRENRTIGAKMVRLIKPSASAMRLLRGPWHIQTLDFPLASNEVAYQLIRATVVYRHQLHLVHYHLSCHVEPWVPKCRTKHFPSKSGSAKPSSVSKAWREMNITHCIQQKLWNRKGRRVLRLRFMCQQQKGNETLELRWHGMTSLDVAFLLLYFNDTDESAQAKLLARGQEELTDRESPFLMRSVRQTCSIASDVPCPSQEQDRSVNNQCSLHPYKVSFHQLGWDHWIIAPRLYTPNYCKGICTGVLPYGLNSPNHAIIQSLVNELVNRSVPQLSCVPYKFLPMSILLIEANGSILYKEYEGMIAQSCTCR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Meis1, myeloid ecotropic viral integration site 1 homolog 2 (Predicted) (A6HP86)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus
InterPro domains:
- IPR008422: KN homeodomain (domain) [294-333]
- IPR032453: Homeobox protein PKNOX/Meis, N-terminal (domain) [73-186]
- IPR001356: Homeodomain (domain) [274-341]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [275-348]
- IPR050224: Three Amino acid Loop Extension (TALE) homeobox (family) [64-348]
Sequence:
MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGNQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPVGMGMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0009719 (response to endogenous stimulus), GO:0048513 (animal organ development), GO:0070848 (response to growth factor), GO:0009612 (response to mechanical stimulus), GO:0031016 (pancreas development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Elongation factor Tu GTP binding domain containing 2, isoform CRA_b (A6HJN2)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR031950: 116kDa U5 small nuclear ribonucleoprotein component, N-terminal (domain) [4-110]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [113-178]
- IPR000795: Translational (tr)-type GTP-binding domain (domain) [129-177]
Sequence:
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDEDEDEDDVGEHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:1901700 (response to oxygen-containing compound), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:1902074 (response to salt), GO:0071466 (cellular response to xenobiotic stimulus), GO:0042220 (response to cocaine), GO:0014070 (response to organic cyclic compound), GO:0010243 (response to organonitrogen compound), GO:0043279 (response to alkaloid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0043229 (intracellular organelle), GO:0005681 (spliceosomal complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: RCG53773 (A6J8Q8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus
InterPro domains:
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [263-349]
- IPR032399: RelB leucine zipper (domain) [1-75]
- IPR037059: Rel homology domain (RHD), DNA-binding domain superfamily (homologous_superfamily) [84-262]
- IPR030492: Rel homology domain, conserved site (conserved_site) [111-117]
- IPR000451: NF-kappa-B/Dorsal (family) [94-269]
- IPR011539: Rel homology domain, DNA-binding domain (domain) [93-270]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [266-369]
- IPR002909: IPT domain (domain) [233-334]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [96-268]
- IPR032400: RelB transactivation domain (domain) [339-516]
- IPR030496: Transcription factor RelB, RHD domain, N-terminal (domain) [96-267]
Sequence:
MPSRRAARESAPELGALGSSDIPSLSRTTEIIDEYIKENGFGLDGAQLSEMPRLVPRGPASLSSVTLGPAAPPPPATPPWNCTLGRLVSPGPCPRPYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCTDGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRMDPILSEPVYDKKDISVVFSTASWEGRADFSQADVHRQIAIVFKTPPYEDLEISEPVTVNVFLQRLTDGVCSEPLPFTYLPRDHDSYGVDKKRKRGLPDVLGELSSSDPHGIESKRRKKKPVFLDHFLPGHSSGLFLPPSALQSADTDFFPGTISLPGLEPPGGPDLLDDGFAYDPSAPTLFTMLDLLPPAPPLASAVVGNGGAGATVVESPGPEPLSLDSFAAPGPGDVGTASLVGSNMFPNQYREAAFGGGLLSPGPEAT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006970 (response to osmotic stress), GO:0104004 (cellular response to environmental stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0062197 (cellular response to chemical stress), GO:0071470 (cellular response to osmotic stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: RCG25760 (A6I3U4)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR048285: Integrin alpha, second immunoglobulin-like domain (domain) [519-587]
- IPR013519: Integrin alpha beta-propellor (repeat) [142-374]
- IPR028994: Integrin alpha, N-terminal (homologous_superfamily) [1-361]
- IPR013649: Integrin alpha, first immunoglubulin-like domain (domain) [358-517]
- IPR048286: Integrin alpha, third immunoglobulin-like domain (domain) [642-836]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [360-851]
- IPR013517: FG-GAP repeat (repeat) [203-298]
- IPR000413: Integrin alpha chain (family) [143-879]
- IPR018184: Integrin alpha chain, C-terminal cytoplasmic region, conserved site (conserved_site) [872-879]
Sequence:
MARERNRGESCGKTCRGDRDDEWMGVSLARQPKADGRVLACAHRWKNIYYETDHILPHGFCYLIPSNLQAKGRMLIPCYEEYKKKYGEEHGSCQAGIAGFFTEELVIMGAPGSFYWAGTLKVLNLTDNTYFKLNDDAIMNRRYTYLGYAVTAGHFSHPSVTDVVGGAPQDEGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNMDGLSDLLVGAPMFSEIRDEGQVTVYLNQGHGVLEEQLTLTGDAAYNAHFGESIASLGDLDDDGFPDVAVGAPMEDDFAGTVYIYHGDAQGIVPQYSMKLSGRKINPILQMFGQSISGGIDMDGNGYPDVTVGAFLSDSVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVTVCFRFHGKNVPGEIGLNYNLTADVAQKEKGQLPRVYFVLLGETAGQVSERLQLTHMDEVCHHYVAHVKRRVQDVISPIVFEAAYSLGEHVIGEEDRELPDLTPVLRWKKGQRIAQKNQTVFERNCRSEDCAADLQLRGKLLLSSVDEKTTHLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFFINMWQKYEFSVIFDTSHLSGEEEILSFIVTAQSGNMERSEALHDNTLTLTIPLVHEVDTSITGIVSPTSFVYGESVDASNFIQLDDQECHFQPVNITLQVYNMGPSTLPGSSVSISFPSRLSPGGAEMFQVQDMVVSQEKGNCSLQRNPTPCIIPQEQENIFHTIFAFFSKSGRKVLDCEKTGSFCLTLHCNLSALPKEESRAIDLYMLLNTEILKKDSSSVIQFMARAKVKVEPALRVVEIANGNPEETLVVFEALHNLEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKNRKENEEAWDWVQKNQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0050840 (extracellular matrix binding), GO:0005515 (protein binding), GO:0005518 (collagen binding), GO:0043236 (laminin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009611 (response to wounding), GO:0042060 (wound healing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0043235 (receptor complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0098636 (protein complex involved in cell adhesion), GO:0098802 (plasma membrane signaling receptor complex), GO:0098797 (plasma membrane protein complex), GO:0008305 (integrin complex), GO:0005886 (plasma membrane)
Protein: Protein Wnt (A6IB97)
Organism: Rattus norvegicus (Rat)
Function: Ligand for members of the frizzled family of seven transmembrane receptors
Subcellular location: Secreted, extracellular space, extracellular matrix
InterPro domains:
- IPR013300: Wnt-7 protein (family) [63-129]
- IPR018161: Wnt protein, conserved site (conserved_site) [5-14]
- IPR005817: Wnt (family) [1-154]
- IPR043158: Wnt, C-terminal domain (homologous_superfamily) [94-154]
Sequence:
MKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0001664 (G protein-coupled receptor binding), GO:0005109 (frizzled binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0198738 (cell-cell signaling by wnt), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0060255 (regulation of macromolecule metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0010033 (response to organic substance), GO:0016055 (Wnt signaling pathway), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010468 (regulation of gene expression), GO:0060070 (canonical Wnt signaling pathway), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 (Predicted), isoform CRA_a (A6I3D4)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR000953: Chromo/chromo shadow domain (domain) [214-260]
- IPR001005: SANT/Myb domain (domain) [618-666]
- IPR017884: SANT domain (domain) [617-668]
- IPR032451: SMARCC, C-terminal (domain) [871-952]
- IPR032448: SMARCC, SWIRM-associated domain (domain) [705-771]
- IPR036420: BRCT domain superfamily (homologous_superfamily) [166-304]
- IPR032450: SMARCC, N-terminal (domain) [31-164]
- IPR049898: MarR-like, BRCT and chromo domains module (domain) [27-301]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [454-541]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [444-671]
- IPR007526: SWIRM domain (domain) [448-545]
Sequence:
MATTAGGGPGAAAGAVGAGGAAAASGLAVYRRKDGGPASKFWESPDTVSQLDSVRVWLGKHYKKYVHADAPTNKTLAGLVVQLLQFQEDAFGKHVTNPAFTKLPAKCFMDFKAGGTLCHILGAAYKYKNEQGWRRFDLQNPSRMDRNVEMFMNIEKTLVQNNCLTRPNIYLIPDIDLKLANKLKDIIKRHQGTFTDEKSKASHHIYPYPSSQEDEEWLRPVMRRDKQVLVHWGFYPDSYDTWVHSNDVDAEIEDAPIPEKPWKVHVKWILDTDVFNEWMNEEDYEVDENRKPVSFRQRISTKNEEPVRSPERRERKASANARKRKHSPSPPPPTATESRKKSGKKGQASLYGKRRNQKDEDEQEDLTKDMEDPTPVPNIEEVLLPKNVNPKKDSENTPVKGGTVADLDEQDEEAVTTGGKEDEDPSKGDPSRSADAGEDNVTEQTNHIIIPSYASWFDYNCIHVIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLTGDVCAVMRVHAFLEQWGLVNYQVDPESRPMAMGPPPTPHFNVLADTPSGLVPLHLRSPQVPAAQQMLNFPEKNKEKPIDLQNFGLRTDIYSKKTLAKSKGASAGREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLENSDASLGPLAYQPVPFSQSGNPVMSTVAFLASVVDPRVASAAAKAALEEFSRVREEVPLELVEAHVKKVQEAARASGKVDPTYGLESSCIAGTGPDEPEKLEGSEEEKMETDPDGQQPEKAENKGENESDEGDKIQDGENEKNSEKERDSDTSEDVKPEEKENEENKELTDTCKERESDTGKKKVEHEISEGNVATAAAAALASAATKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREKEALEQQRQQLLTERQNFHMEQLKYAELRARQQMEQQQHGQPPQQAHQHPGGPGLAPLGAAGHPGMMPHQQPPPYPMMHHQMPPPHPPQPGQIPGPGSMMPGQPMPGRMIPTVAANIHPTGSGPTPPGMPPMPGNILGPRVPLTAPNGMYPPPPQQPPPPPADGVPPPPVPGPPASATP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0003006 (developmental process involved in reproduction), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048608 (reproductive structure development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0061458 (reproductive system development), GO:0001655 (urogenital system development), GO:0030850 (prostate gland development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Acetyl-coenzyme A synthetase (A6KHF6)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR011904: Acetate-CoA ligase (family) [47-669]
- IPR025110: AMP-binding enzyme, C-terminal domain (domain) [557-635]
- IPR020845: AMP-binding, conserved site (conserved_site) [284-295]
- IPR042099: ANL, N-terminal domain (homologous_superfamily) [47-543]
- IPR000873: AMP-dependent synthetase/ligase domain (domain) [109-501]
- IPR045851: AMP-binding enzyme, C-terminal domain superfamily (homologous_superfamily) [544-676]
- IPR032387: Acetyl-coenzyme A synthetase, N-terminal domain (domain) [51-107]
Sequence:
MAARSLGSGVGRLLRGLHGHSGQSGWLLSLSRWTTTRFLGSVPAAAQLGSYPALSAQAAQEPAAFWGPLARDTLVWDTPYHTVWDCDFRTGKIGWFLGGQLNVSVNCLDQHVQKSPDTIALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAIHTVVFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKNCPTVQHVLVAHRTDTKVPMGNLDIPLEQEMANEAPVCTPESMNSEDMLFMLYTSGSTGTPKGLVHTQAGYLLYAAMTHKLVFDYHPGDVFGCVADIGWITGHSYVVYGPLCNGATTVLFESTPVYPDAGRYWETVQRLKINQFYGAPTAVRLLLKFGDAWVKKYDRSSLRTLGSVGEPINHEAWEWLHKVVGDGRCTLVDTWWQTETGGICIAPRPSEDGAEILPGMAMRPFFGIVPALMDEKGNVVEGGDVSGALCISQAWPGMARTIYGDHQRFVDAYFRTYPGYYFTGDGAHRTEGGYYQITGRMDDVINISGHRLGTAEIEDAMADHPAVPETAVIGYPHDIKGEAAFAFIVLKDDVRDANVVVNELKLAVATKIAKYAVPDQILVVKRLPKTRSGKVMRRLLRKIITSRGQDLGDTTTLEDPSVITEIMSAFREYEEQRAATN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0016877 (ligase activity, forming carbon-sulfur bonds), GO:0016878 (acid-thiol ligase activity), GO:0016405 (CoA-ligase activity), GO:0003987 (acetate-CoA ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006083 (acetate metabolic process), GO:0006082 (organic acid metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0019541 (propionate metabolic process), GO:0006631 (fatty acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0006633 (fatty acid biosynthetic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0046459 (short-chain fatty acid metabolic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)