Protein: Sodium channel protein (A0A8M2B935)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
Sequence:
MAAPLLAPPGPNSYKYFTRESLREIEKRIEEEKAKPPPKPDNSYRDDDDENKPKPNGDLEAGKSLPFIYGDIPPGMVATPLEDFDPFYINQKTFVVLNKGKTIFRFSATPALYMISPFNLARRIAIKILIHSVFSMFIMCTILTNCVFMTFSNPPEWSKQVEYTFTGIYTFESAVKIIARGFCIDGFTFLRDPWNWLDFMVISMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRQKCVIWPINITEMFPDVNGSRAFNWDEYILNETNFYFLPDQLDALLCGNSSDSGRCPEGYTCMKAGRNPNYGYTSFDSFGWAFLALFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATMEEAERKEAEFKAMLEQLKKQQEDAQANAMATSAGTVSEDVVEDDGDGEGNLSCSSSEMSKLSSKSAKERRNRKKKWRQKEQDKEKGDSEKFVKSESDDGSRRRFRFPDNRLGRRSSIMNQSLLSIPGSPFPSRRNSKSSIFSRCKDGGSENEFADDEHSTVEEYDERRDSFLSPQRRSSYTGFYGKRNSTVDCNGVVSLIGPGPGGRLLPEVIIDKAATDDSPTTDLEIKKKLSGSLMVSVEQLNTSFGRKERANSVMSALTNTLVEELEESQRKCPPCWYKFANTFLIWECGPLWMSIKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTPQFEHVLSVGNLVFTGIFTAEMFAKLVAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAQDCELPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAASDDDGEMNNLQIAVIRIKKGIAWVKAKVRELVNIILGRKVTDEAKPLDDMYDRKLNCIANHTGVDISRDLDYQKNGNGTTSGIGSSVGKYMIDDDHMSFIHNPNLTVCVPIAVGESDFENLNTEDFSSESEAEGSKELDDISSSEGSTIDIKPEVEEAVVVETVEEYVDPEACWTEACIARYKCCDVPITEGWGKNWWFLRKTCYLIVEHNWFETLIIFMILLSSGALAFEDVYIEQRKTIRIILEYADMVFTYIFILEMLLKWVAYGFVKYFTNAWCWLDFFIVDVSIVSLIANALGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNMFAGKYYYCYNETEKAYFELDVVNNKSECFALIEQNYTEVRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRRVEDQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKLQGMVFDFVTQQVFDISIMILICLNMVTMMVETDDQSQETENILYWINFIFIVAFTSEFVLKLFALRHYYFTNGWNIFDCVVVILSIVGMFLADLIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKRESGIDDMYNFETFGNSMICLFMITTSAGWDGLLAPILNYPPDCEPTKENPGTSVKGNCGNPSVGIFFFVMYIIVSFLIVVNMYIAIILENFSVATEESADPLCEDDFESFYEIWEKFDPTASQFITFAKLGDFADTLEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGDLDMMRQQMEERFIAANPSKVSFEPITTTLRRKQEHMSAGVIQRAFRAHLIRKGFICKRLLSSSRLENGGTNQDKKEGTPSTASLPSYDSVTKPEKEKLEESDSKGKKGKNQKDVKESKF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005272 (sodium channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005248 (voltage-gated sodium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0051234 (establishment of localization), GO:0065008 (regulation of biological quality), GO:0051239 (regulation of multicellular organismal process), GO:0055085 (transmembrane transport), GO:0003008 (system process), GO:0003012 (muscle system process), GO:0034220 (monoatomic ion transmembrane transport), GO:0044057 (regulation of system process), GO:0098660 (inorganic ion transmembrane transport), GO:0042391 (regulation of membrane potential), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0090257 (regulation of muscle system process), GO:0001508 (action potential), GO:0006811 (monoatomic ion transport), GO:0006936 (muscle contraction), GO:0014819 (regulation of skeletal muscle contraction), GO:0006937 (regulation of muscle contraction), GO:0035725 (sodium ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0006942 (regulation of striated muscle contraction), GO:0030001 (metal ion transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0001518 (voltage-gated sodium channel complex), GO:0034703 (cation channel complex), GO:0034706 (sodium channel complex)