lokahq/bioreason-rl huggingface dataset:
Protein: Similar to adiponutrin, isoform CRA_b (A6HTB3)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR002641: Patatin-like phospholipase domain (domain) [10-179]
- IPR016035: Acyl transferase/acyl hydrolase/lysophospholipase (homologous_superfamily) [5-255]
- IPR033562: Patatin-like phospholipase domain-containing protein (family) [6-278]
Sequence:
MYDPERRWSLSFAGCGFLGFYHIGATLCLSERAPHILREARTFFGCSAGALHAVTFVCSLPLDHIMEILMDLVRKARSRNIGTLHPFFNINKCVRDGLQETLPDNVHQIISGKVYISLTRVSDGENVLVSEFHSKDEVVDALVCSCFIPLFSGLIPPSFRGERYVDGGVSDNVPVLDAKTTITVSPFYGEHDICPKVKSTNFLQVNITNLSLRLCTGNLHLLTRALFPSDVKVMGELCFQGYLDAFRFLEENALTEAIKDRGGYLNKVCNLLPIRILSYILLPCTLPVESAIAAVHRLVMWLPDIHEDIQWLQWATSQVCARMTMCLLPSTRSRASKDNHQTLKHGYHPSLHKPQGSSAGL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0051716 (cellular response to stimulus), GO:0001101 (response to acid chemical), GO:1901698 (response to nitrogen compound), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0070887 (cellular response to chemical stimulus), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1902074 (response to salt), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0009743 (response to carbohydrate), GO:0071229 (cellular response to acid chemical), GO:0032870 (cellular response to hormone stimulus), GO:0043200 (response to amino acid), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:1902075 (cellular response to salt), GO:1901699 (cellular response to nitrogen compound), GO:0014070 (response to organic cyclic compound), GO:0045444 (fat cell differentiation), GO:1901701 (cellular response to oxygen-containing compound), GO:1901653 (cellular response to peptide), GO:0050872 (white fat cell differentiation), GO:0071375 (cellular response to peptide hormone stimulus), GO:0032868 (response to insulin), GO:0034285 (response to disaccharide), GO:0071407 (cellular response to organic cyclic compound), GO:0071230 (cellular response to amino acid stimulus), GO:0032869 (cellular response to insulin stimulus), GO:0009744 (response to sucrose)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005811 (lipid droplet)
Protein: Syntaxin binding protein 3, isoform CRA_a (F7EZS9)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR027482: Sec1-like, domain 2 (homologous_superfamily) [141-575]
- IPR043154: Sec1-like, domain 1 (homologous_superfamily) [1-135]
- IPR036045: Sec1-like superfamily (homologous_superfamily) [9-585]
- IPR043127: Sec1-like, domain 3a (homologous_superfamily) [251-359]
- IPR001619: Sec1-like protein (family) [14-585]
Sequence:
MAPPVTERGLKSVVWRKIKTTVFDDCRKEGEWKIMLLDDFTTRLLSSCCKMTDLLEEGVTVIENIYKNREPVRQMKALYFISPTPKSVDCFLRDFGSKSEKKYKAAYIYFTDFCPDSLFNKIKASCSKSIRRCKEINISFIPHESQVYTLDVPDAFYYCYSPDPSNAGRKEAVMEAMAEQIVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDENGLIKGKTQSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIEKDTYKYKTDGKEKEAVLEEDDDLWVRVRHRHIAVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKMPHFRKQISKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDAEGQRVKDSMLVLLPVLLNKNHDNCDKIRAVLLYIFGVNGTTEENLDRLIHNVKIEDDSDMIRNWSHLGVPIVPPSQQAKPPRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSRCPAVWNGSGAVSARQKPRTNYLELDRKNGSRLIIFVIGGITYSEMRCAYEVSQAHKSCEVIIGSTHILTPRKLLDDIKMLNKSKDKVSFLKDE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0000149 (SNARE binding), GO:0019905 (syntaxin binding), GO:0017075 (syntaxin-1 binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0022406 (membrane docking), GO:0051640 (organelle localization), GO:0140352 (export from cell), GO:0140029 (exocytic process), GO:0006904 (vesicle docking involved in exocytosis), GO:0140056 (organelle localization by membrane tethering), GO:0032940 (secretion by cell), GO:0006810 (transport), GO:0046903 (secretion), GO:0016192 (vesicle-mediated transport), GO:0006887 (exocytosis), GO:0048278 (vesicle docking)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0045177 (apical part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0016323 (basolateral plasma membrane)
Protein: Cyclin T1 (Predicted) (A6KC89)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR013763: Cyclin-like domain (domain) [43-142]
- IPR043198: Cyclin/Cyclin-like subunit Ssn8 (family) [8-352]
- IPR006671: Cyclin, N-terminal (domain) [13-149]
- IPR036915: Cyclin-like superfamily (homologous_superfamily) [7-199]
Sequence:
MEGERKNNNKRWYFTREQLENSPSRRFGVDSDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFHRYSMAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACAYQAAMKTKPDDRGADENTSEQTILNMISQTSSDTTIAGLMSMSAASTGAVPSLPASEESSSSLTSVDMLQGERWLSSQPPFKLEASQGHRTSENLALIGVDHSLQHDGSNAFVSQKQTSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHDSHSSVILKMPIEGSENPERPFLDKADKSALKMRLPVAGGDKAASSKPEEIKMRIKVHSAGDKHNSVEDSVAKSREHKEKQRTHPSNHHHHHNHHSHKHSHLQLPVGPVSKRPSDPKHSSQTSTLAHKTYSLSSTLSSSSSTRKRGPPEETGAAVFDHPAKIAKSTKSSSLNFPFPPLPTMTQLPGHSSDTSGLPFSQPSCKTRVPHVKLDKGPPGANGHNTTQSIDYQDTVNMLHSLLSAQGVQPTQPPAFEFVHSYGEYMNPRAAGISRSGNTDKPRPPPLPSEPPPPLPPLPK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0009410 (response to xenobiotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: V-ets erythroblastosis virus E26 oncogene homolog 2 (Avian) (Mapped), isoform CRA_e (A6KPT7)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR013761: Sterile alpha motif/pointed domain superfamily (homologous_superfamily) [66-134]
- IPR003118: Pointed domain (domain) [85-137]
Sequence:
MNDFGIKNMDQVAPVANSFRGTLKRQPAFDTFDGSLFAVLPSLSEEQTLQEVPTGLDSVSHDSATCELPLLTPCSKAVMSQALKATFSGFHKEQRRLGIPKNPWLWNEQQVCQWLHWATNEFSLVNACMPREKCFAV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Putative glycogen storage disease type 1b protein (Q9Z296)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR021159: Glycerate/sugar phosphate transporter, conserved site (conserved_site) [133-149]
- IPR051337: Organophosphate:Pi Antiporter (family) [2-428]
- IPR020846: Major facilitator superfamily domain (domain) [13-419]
- IPR000849: Sugar phosphate transporter (family) [2-428]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [3-426]
- IPR011701: Major facilitator superfamily (family) [18-380]
Sequence:
MAAQGYGYYRTVIFTAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVPAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGSLCVVVSFFCLLLIHNEPADVGLRNLDPRPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLSVYGNPRHSLLLLMMAGMAASMFLFRVTVTSDSPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICIASTVVFFLLRNIRTKMGRVSKKAE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015605 (organophosphate ester transmembrane transporter activity), GO:1901505 (carbohydrate derivative transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0051234 (establishment of localization), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0009991 (response to extracellular stimulus), GO:1901700 (response to oxygen-containing compound), GO:0007584 (response to nutrient), GO:0010033 (response to organic substance), GO:0006810 (transport), GO:0009743 (response to carbohydrate), GO:0071702 (organic substance transport), GO:0014070 (response to organic cyclic compound), GO:0031667 (response to nutrient levels), GO:0015748 (organophosphate ester transport), GO:0034284 (response to monosaccharide), GO:1901264 (carbohydrate derivative transport), GO:0009746 (response to hexose), GO:0009749 (response to glucose)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Chromo domain-containing protein (D3ZRS6)
Organism: Rattus norvegicus (Rat)
InterPro domains:
Sequence:
MASNKTTLQKMGKKQNGKSKKAEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKAGKEKDGTKRKSLSDSESDDSKSKKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEVNMKCPQIVIAFYEERLTWHSCPEDEAQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0140297 (DNA-binding transcription factor binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0009725 (response to hormone), GO:0048545 (response to steroid hormone), GO:0032870 (cellular response to hormone stimulus), GO:0014070 (response to organic cyclic compound), GO:1901654 (response to ketone), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:1901701 (cellular response to oxygen-containing compound), GO:1901655 (cellular response to ketone), GO:0031960 (response to corticosteroid), GO:0071548 (response to dexamethasone), GO:0071383 (cellular response to steroid hormone stimulus), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0051384 (response to glucocorticoid), GO:0071549 (cellular response to dexamethasone stimulus), GO:0071384 (cellular response to corticosteroid stimulus), GO:0071385 (cellular response to glucocorticoid stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0000792 (heterochromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0005634 (nucleus)
Protein: RCG27932, isoform CRA_b (A6IEQ9)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR003649: B-box, C-terminal (domain) [266-392]
- IPR019786: Zinc finger, PHD-type, conserved site (conserved_site) [795-836]
- IPR001487: Bromodomain (domain) [867-972]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [69-78]
- IPR019787: Zinc finger, PHD-finger (domain) [792-839]
- IPR001965: Zinc finger, PHD-type (domain) [794-837]
- IPR036427: Bromodomain-like superfamily (homologous_superfamily) [851-982]
- IPR000315: B-box-type zinc finger (domain) [158-259]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [42-849]
- IPR018359: Bromodomain, conserved site (conserved_site) [884-945]
- IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [763-839]
- IPR001841: Zinc finger, RING-type (domain) [52-131]
Sequence:
MEVAVEKAAAAAALAGAPAAAAPSGENEAESRQGPDSESGGEVSRLNLLDTCAVCHQNIQSRVPKLLPCLHSFCQRCLPAPQRYLMLTAPSLGSAETPPPAPVPAPAPGSPAGGPSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKYTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINLGSLVIEEKESQPQMPKQNPVVEQSSQPPGGLPSNQLSKFPTQISLAQLRLQHIQQQHPPPRLINFQNHSPKPNGPVLPPYPQQLRYPPSQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQATPTTASSSSSTPSSPTITSAAGYDGKAFSSPMIDLSAPVGGSYNLPSLPDIDCSSTILLDNIARKDTSVDPGQPRPPSNRTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNTNYPRSILTSLLLNSSQSSASEETVLRSDAPDSTGDQPALHHENSPNGKSEWPDASQKSPVHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLTCHVPTLTHFPSGEWICTFCRDLSKPEVEYDCDAPSHNSDKRKSEGLTKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYCMYTKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLESYFEELLKNLYPEKRFPKLEFRHDVEDCKFSDDSDDDFVQPRKKRLKSMEDRQLLK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1901700 (response to oxygen-containing compound), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0010243 (response to organonitrogen compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)
Protein: Wolfram syndrome 1 homolog (Human) (A6IJW7)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR045458: Wolframin, Sel1-like repeat (repeat) [100-176]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [76-240]
- IPR026208: Wolframin (family) [79-888]
- IPR045461: Wolframin, OB-fold domain (domain) [772-889]
- IPR026209: Wolframin family (family) [3-889]
- IPR045400: Wolframin, cysteine-rich domain (domain) [668-771]
- IPR045460: Wolframin, EF-hand domain (domain) [177-256]
Sequence:
MSSGTPPPSPSGPPPPPAPQPQARARLNATTSLEQDKIEPPRAPRPQPDSSAGRSAGEATTPEPWAPHASSREGTDKAGPMKADVEIPFEEILEKAKAGDPKAQTEVGKHYLRLANDADEELNSCSAVAWLILAAKQGRREAVKLLRRCLADRKGITSENEAEVKQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVSELLENVGQVNEQDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVELTKKYAKGIIPNNLFLQDEDEDEDELSGKSPEDLPLRQKVVKYPLHAIMEIKEYLIDVASKAGMHWLSTIVPTHHINALIFFFIISNLTIDFFAFFIPLVVFYLSFVSMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQAEVNFGWNHLEPYIHFLLSVVFVIFSFPLASKDCIPCSELAVVSAFFTVTSYMSLSSSAEPYTRRALVTEVAAGLLSLLPTMPVDWPFLKALGQTFFTVPIGHFIILNVSLPCLLYVYLFYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSVVILLQSTGLGLVRASIGYFLFLFALPILVAGLALMGTVQFARWFLSLDLTKIMVTTVICSVPLLFRWWTKANFSVVGMVKSLTRSSIVKLILVWLTAILLFCWFYVYRSEGMKVYNSTLTWQQYGFLCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTEIDNSAESAINMLPFFLGDWMRCLYGEAYPSCSSGNTSTAEEELCRLKQLAKHPCHIKKFDRYKFEITVGMPFGTNGNRGHEEDDITKDIVLRASSEFKDVLLNLRQGSLIEFSTILEGRLGSKWPVFELKAISCLNCMTQLSPARRHVKIEQDWRSTVHGALKFAFDFFFFPFLSAA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0070628 (proteasome binding), GO:0048306 (calcium-dependent protein binding), GO:0005516 (calmodulin binding), GO:0140297 (DNA-binding transcription factor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0042221 (response to chemical), GO:0048856 (anatomical structure development), GO:0007610 (behavior), GO:0007635 (chemosensory behavior), GO:0048513 (animal organ development), GO:0031016 (pancreas development), GO:0042048 (olfactory behavior)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0030054 (cell junction), GO:0031090 (organelle membrane), GO:0008021 (synaptic vesicle), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0030133 (transport vesicle), GO:0070382 (exocytic vesicle), GO:0030672 (synaptic vesicle membrane), GO:0030658 (transport vesicle membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0099501 (exocytic vesicle membrane), GO:0097708 (intracellular vesicle)
Protein: Crumbs homolog 3 (Drosophila), isoform CRA_b (A6KQS4)
Organism: Rattus norvegicus (Rat)
InterPro domains:
Sequence:
MATPGLGLLLAFGLPMLPSGWSQETPDSFTNSTTQPPDGGGSNGGLSSEAIVAITVVFSILGTLLIAVGLFLLMRKLREKRQTEGTYRPSSEEQFSHAAAEARAPQDSKEPVRGCLPI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0044089 (positive regulation of cellular component biogenesis), GO:0051130 (positive regulation of cellular component organization), GO:0044087 (regulation of cellular component biogenesis), GO:1901890 (positive regulation of cell junction assembly), GO:1901888 (regulation of cell junction assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)
Protein: Gamma-secretase subunit APH-1 (A6K331)
Organism: Rattus norvegicus (Rat)
Function: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors
Subcellular location: Membrane; Multi-pass membrane protein
InterPro domains:
- IPR009294: Gamma-secretase subunit Aph-1 (family) [1-249]
Sequence:
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFVTAGGSLRSIQRSLSCRRQEDSRVMVYSALRIPPED
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0007610 (behavior), GO:0007626 (locomotory behavior)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0008021 (synaptic vesicle), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0045202 (synapse), GO:0030133 (transport vesicle), GO:0042734 (presynaptic membrane), GO:0005739 (mitochondrion), GO:0098590 (plasma membrane region), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070382 (exocytic vesicle), GO:0005769 (early endosome), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)