lokahq/bioreason-rl huggingface dataset:
Protein: Branchpoint-bridging protein (A0A8M9Q1R8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns
Subcellular location: Nucleus
InterPro domains:
- IPR047086: Splicing factor 1, helix-hairpin domain superfamily (homologous_superfamily) [43-126]
- IPR045071: KH domain-containing BBP-like (family) [11-378]
- IPR004087: K Homology domain (domain) [134-227]
- IPR032570: Splicing factor 1, helix-hairpin domain (domain) [18-130]
- IPR001878: Zinc finger, CCHC-type (domain) [278-294]
- IPR055256: KHDC4/BBP-like, KH-domain type I (domain) [146-227]
- IPR036612: K Homology domain, type 1 superfamily (homologous_superfamily) [132-260]
Sequence:
MATGANATPLDFGQKKRKRSRWSSETPDQKTVIPGMPTVIPPGLTRDQERAYIVQLQIEDLTRKLRTGDLGIPVNPEDRSPSPEPIYNSEGKRLNTREYRTRKKLEEERHSLITEMVGLNPEFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECCAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSTEPRSITNTTLCTKCGGAGHISSDCKFTSSFAPRPGEPPQSAQDKARMDKEYLSLMAELGEAPVPSSGGGHNNAPPSGPRPSGPNNNQPPPNRPPWMNSGPTDNRNFHGMHQGPGGPHNFPPPMPNMGGPPMPPNPNGMPPPWMQPPPPPMGQGPAPPGHPMGLLPPPMGMMPPPPPPPNNQPPPPPSGPLPPWQQQAPPPPPTSSMATSAPMPWQQNTTTTSTPATGNLPPWQQPQQTAASASQPPPPMGNPSMVPPPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPPPPPPPMDPNFVTMMGIPGMPPYGMPPAPPPPPPQS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060041 (retina development in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Bromodomain-containing protein 8 isoform X6 (A0A8M2B3A4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR037966: Brd8, Bromo domain (domain) [664-767]
- IPR036427: Bromodomain-like superfamily (homologous_superfamily) [630-778]
- IPR001487: Bromodomain (domain) [660-768]
Sequence:
MSTGMGKHKMLSLGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFSESGRPPDWFSQKHCASQYSQLLETTEAPKRKRGEKGEVVETIEDVIVRRLTAERIEELKRLIKDTQEKYRKLKKEVDLIQAGHVDPKLEELWAEIELKKKQEEEEAEQKKRATEAAYQIRQAAKNTPKRVPSVTVRSPPGASSPSMDILQPDASQPMTDESCASPMAQGVTVFMPVSDVMGPGPKESGLSSLVDDSPQKKHLAPKATPPPSPLLSELLKKGSLIAASSRLVVEGEVATGLSNGSHAVELHTSATVLPATQDITADAPTLSRLLESVTPAQQPVSADPPKPPTVVPPAPDHLSVPKSGDAAIAEGSGAEAVMAGSSTPAEVEGKETELVEEDTVVSVSYMGHELDLETVGDIIAIIEEKVDDPVEALDAAAVEAALSLCEDPAVGGHPLTSPWESQTFKAAEPEPMIQQSAIPAGAESAPNSAIVQGEMEVLVEEATETEAVEGVTEEPEVPSAPETEQSQDSEVKTEVERGGEGEGGVEETAQPENRTPSPAVKCEGEDWVQPETVTPCLDSEDSSASAKDAKEVKEEDGGSEVDVDEGMEMKECGDGDGEGPYLSEVDPPASESEDGYGSHSQRYTTADSTASSPASSQFSMCSEDQEALQAQKIWKKAIMLVWRAAANHRYASVFLQPVSDDIAPGYHSIVHRPMDLSAIKKNIESGQIRTTAEFQRDIMLMFQNAVMYNSSDHDVYHMALEMQRDVLEQIQQFLATQLIMQTSESGISTKSLRGREANRKQDPNEKDGGTRGRRSAIEADMKMKK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0030097 (hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: ATP receptor (A0A8M9PI33)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
Sequence:
MSESVGCCDSVSQCFFDYYTSKILIIRSKKVGTLNRFTQALVIAYVIGYVCVYNKGYQDTDTVLSSVTTKVKGIALTNTSELGERIWDVADYIIPPQEDGSFFVLTNMIITTNQTQSKCAENPTPASTCTSHRDCKRGFNDARGDGVRTGRCVSYSASVKTCEVLSWCPLEKIVDPPNPPLLADAENFTVLIKNNIRYPKFNFNKRNILPNINSSYLTHCVFSRKTDPDCPIFRLGDIVGEAEEDFQIMAVHGGVMGVQIRWDCDLDMPQSWCVPRYTFRRLDNKDPDNNVAPGYNFRLGNSTSSQHF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0035381 (ATP-gated ion channel activity), GO:0004931 (extracellularly ATP-gated monoatomic cation channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity), GO:0005231 (excitatory extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0071702 (organic substance transport), GO:0006812 (monoatomic cation transport), GO:0006816 (calcium ion transport), GO:0030001 (metal ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Cytospin-A (A0A8M9PIS7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration
Subcellular location: Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton. Cell junction, gap junction
InterPro domains:
- IPR001715: Calponin homology domain (domain) [1039-1144]
- IPR050540: F-actin Monooxygenase Mical (family) [408-1144]
- IPR036872: CH domain superfamily (homologous_superfamily) [1038-1145]
Sequence:
MCSPRKITSAGVRLRCKCIKNLEPSMKKATKPTAATSRTSVGTKAPGRSEGSSNMGTGGKMTNKTQSSAPLSKAKSSDDLPAVSAGSGSVSASNSNTTARNKRGSSSQITSNTETRSKTTSGLSGRRATSTVSKEPGLTRDNLRERSRTSVAKKPTDTMPQKRSRCRTLPDSESKMSKSRSDSQISHKAVLECQVNDLLGLAKSKDLEILHLRSELRGMRTQLGLEELEAPNQEQVSQETMQPPEKEVISATDVESTLLLLQDQNQGILDELNMLKSENRMLKDRLNALGFSLEQRLDSPEKSLRCLPMSPEHVVGGDSSSGGHSESVRGGMRASSAEGSAQGSTEDLLSEQRHLGSPDAVDSECSEAYQPITSSDDALDAPSGCGSSSESEGGLPSREHSRRGSSGNTSEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELSTENERLGEERAILVDSLCQQGERLELYGRQLEYFRGLLDEHCVAYVKDDEDAKSGRYVELERRYAELNEGSRFEREQLLGVQQQLSSALKMAEHENAEAQGLMAALKERVIMAERAVEIERRERAVAKAELEALRVLSEGEQVELNRCRIQLEQERQRVAQLLSIHNAGDKTDIRHLLESERLDKERAEAKAAQLKEELGHTRSEAAQLQEAISKLEDEFRAFRDDVQSQLAEQKRLLEQQCSELEEKDTEIADMKETIFELEDEVEQHRAVKLHDNLIISDLENSIKKLHDQKYDMEKEIKVLHRKLREESAEWRQFQADLQTAVIIANDIKTEAQEEIGDLRRRLQEAQEKNEKMNKELEELKSRKQDEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPSPTVKTLIKSFDSASQGPVQGSPTAAAAAVAAATAISRTPLSPSPVKTPPAAAVSPIQRHTISSKPLSSMLDKRPSFNDLNIPEHLLRTSPVTRPGCPIQRVTNMDTSKAISVSRRSSEELKRDLLAPESSAPSSLMSSPQLSLSSNASSPTASITPTTRGRLREERKDPLSALAREYGGSKRNALLRWCQKKTEGYQNIDITNFSSSWNDGLAFCAILHTYLPAHIPYHELNSLDKRRNFTLAFQAAESVGIKSTLDIGEMVHTERPDWQSVMTYVTSIYKYFET
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008013 (beta-catenin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009887 (animal organ morphogenesis), GO:1904888 (cranial skeletal system development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0097094 (craniofacial suture morphogenesis), GO:0060349 (bone morphogenesis), GO:0048705 (skeletal system morphogenesis), GO:0060348 (bone development), GO:0001501 (skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: tRNA-splicing endonuclease subunit Sen54 isoform X1 (A0A8M9PNE7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR024337: tRNA-splicing endonuclease, subunit Sen54 (family) [11-502]
- IPR024336: tRNA-splicing endonuclease, subunit Sen54, N-terminal (domain) [64-131]
Sequence:
MADADASADAGNKQSVYHELLSPSELFEARSRSHKIPVRGQKEFLPSGSEQQSQRLQHSLEEHWTLLAEERVERLGNLVNAVWSPEEKLVELQSPAGKFWQTMGFSERGKQYLQPEEALYLMECGNVQVFYRDLPLSIQDGYERFLSSDTVTLHQYQVFGHLKRLGYVVNRFDPSHLSHSSVSSTYERQLNLPASDKQKKQLKRKRSQSPVSSDKHGISTEEKTTSEAHNELAETSKLPADLQEPVHLADAPERTWWMEEDVQQKHPKTQTAAPRWDFSSISFPDLGSRRRSERLASPHRSLLPENVDVGECDVSRWLGRLNMKQEKLSRRDMERQRERDRYRRDVNSDREVRRCRNWAEYSELMEERRRRRRKHRPEHLWEREETPLTQPGQCTSHRELLDQIGIIKSSTFSEGLSRLSPSDQWKISFDVYQPDTVAEFKKSHPGKPYTRMCVCSFAGPVPDLHAVKQLSFQSQDVPVTFAVVDHGDISFYCFKDFKLPTDVY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0060322 (head development), GO:0009887 (animal organ morphogenesis), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0048854 (brain morphogenesis), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: dynamin GTPase (A0A8M9PW32)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR022812: Dynamin (family) [7-736]
- IPR000375: Dynamin stalk domain (domain) [215-501]
- IPR001849: Pleckstrin homology domain (domain) [518-625]
- IPR030381: Dynamin-type guanine nucleotide-binding (G) domain (domain) [28-294]
- IPR001401: Dynamin, GTPase domain (domain) [6-294]
- IPR045063: Dynamin, N-terminal (domain) [34-207]
- IPR003130: Dynamin GTPase effector (domain) [646-737]
- IPR019762: Dynamin, GTPase region, conserved site (conserved_site) [57-66]
- IPR020850: GTPase effector domain (domain) [651-742]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [3-304]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [518-645]
Sequence:
MGNRGMEELIPLINKLQDAFSSIGQSCNLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLVNNKAEYAEFLHCKGRKFVDFDEVRQEIEAETDRITGSNKGISPIPINLRVYSPNVLNLTLIDLPGMTKVAVGDQPPDIEHQIRDMIMQFITRESCLILAVTPANMDLANSDALKVAKEVDPQGLRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIDGRKDIRAALAAERKFFLSHPSYRHMAERMGTPHLQKALNQQLTNHIRDTLPGLRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKCIEGSGDQVDTAELSGGARINRIFHERFPFELVKIVFDEKELRREISHAIKNVHGVRTGLFTPDLAFETIVKKQIHKLKEPSLKCVDLVVSELTTVVRKSSKKLSSYPRLREETERIVTTYVREREGKTKDQVLLLIDTELSYINTNHEDFIGFANAQQRNIVNKKRAIPNQGEILVIRKGWLTLNISIMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKLRDVEKGFMSTKHIFAIFNTEQRNVYKDLRQIELACDSQEDMDSWKASFLRAGVYPEKDQVESEEAAPADSFSMDPQLERQVETIRNLVDSYIGIVNKTIRDLMPKTIMHLMINSAKDFIHSELLAYLYSSGDQNSLMEESADQAQRRDEMLRMYHAIKEALSIIGDISTSTISTPVPPPVNDSWIPETSPTPQRRPPTSAPPPNRPPAVRGPTPGPPPLNPTPSFAAPPIPSRPGQPMNAFGNSSQDPFSAPPQIPSRPARIPPGVPSRRPPGAPNRPTIIRPAEPSLLD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0061061 (muscle structure development), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0002009 (morphogenesis of an epithelium), GO:0061053 (somite development), GO:0060429 (epithelium development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0060026 (convergent extension), GO:0043009 (chordate embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0012505 (endomembrane system), GO:0005905 (clathrin-coated pit), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane)
Protein: Transcription factor EB isoform X3 (A0A8M9Q799)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [181-277]
- IPR024098: Transcription factor EB, bHLHzip domain (domain) [176-266]
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [185-244]
- IPR031867: MiT/TFE transcription factors, N-terminal (domain) [7-109]
- IPR021802: MiT/TFE transcription factors, C-terminal (domain) [272-429]
Sequence:
MRWNDSQVQTHLENPTDYHIRQSQRQQVKEYLSTTYATKQAVHAVTSLVQPSPPPMVQAQTGSAPPNMHSPCMRTEQLMNSAGNSAPNSPMAMLNISSSHENEMDDVIDNIISLQSSYDDIQAYNDPVVQMPNTLPLSSSHLDVYTGPGMSGSAIAMTSNSCPANLAIKRELSDVEARAMAKERQKKDNHNLIERRRRFNINDRIKELGTMIPKTNDLDVRWNKGTILRASVDYIKRMQKDVQRTREVENNFRRMEMANKQLWLRIQELERQAQIHGLPSNSPSGLTNTDHQNPFIKQESSPEENHLQHQSHLPPRYPQQHPQPHPQLHQHQHLHPQPPLQYPAVGSSQHFDLAQSLDLCDGGIPGYQDGLGDLGFLGGGIAQMGKKSELSFLLMEEALSPLGGDPLLSAMSPEASVDSSRRSSFSIEDSDIQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007272 (ensheathment of neurons), GO:0008366 (axon ensheathment), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0032291 (axon ensheathment in central nervous system), GO:0021782 (glial cell development), GO:0022008 (neurogenesis), GO:0010001 (glial cell differentiation), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0042552 (myelination), GO:0048709 (oligodendrocyte differentiation), GO:0042063 (gliogenesis), GO:0022010 (central nervous system myelination), GO:0014003 (oligodendrocyte development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Glutamate receptor 4 isoform X4 (A0A8M9QLC3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR015683: Ionotropic glutamate receptor (family) [58-397]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [16-386]
- IPR001828: Receptor, ligand binding region (domain) [35-376]
Sequence:
MRILVLIPLLWGLGEGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNATEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLVTPSFPAEGETQFVLQLRPSIRGALLSLLDHYDWSRFVFLYDTDRGYAVLQAIMEKAGQNGWQVSAICVENFNDASYRRLLEDLDRRQEKKFVIDLEAERLQNILEQIVSVGKHVKGYHYIVANLGFKDISLERFMHGGANVTGFQLVDFSKPMVIKLMQRWNKLDQREYPGSESPPRYTSSLTYDGVLVMAEAFRNLRRQKIDISRRGNAGDCLANPAAPWNQGIDMERTLKQVRIQGLTGNIQFDHYGRRVNYTMDVFELKSNGPRKIGYWNDLDKLVLVQNELSMGNDSAMENRTVIVTTIMAMENFTSAGSSSFPSMLKNPLFRH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004984 (olfactory receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0030182 (neuron differentiation), GO:0007399 (nervous system development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0036477 (somatodendritic compartment), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0097447 (dendritic tree), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0030425 (dendrite), GO:0043005 (neuron projection)
Protein: receptor protein serine/threonine kinase (A0A8M9QNI7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single- pass type I membrane protein
InterPro domains:
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [253-265]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [130-415]
- IPR000719: Protein kinase domain (domain) [129-420]
- IPR003605: GS domain (domain) [99-129]
- IPR000333: Ser/Thr protein kinase, TGFB receptor (family) [6-422]
- IPR017441: Protein kinase, ATP binding site (binding_site) [135-156]
- IPR045860: Snake toxin-like superfamily (homologous_superfamily) [1-47]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [105-416]
Sequence:
MKYEGSHFQCKDSQFAQTRRTIECCQFDFCNQDLKPELPPRDSEPPDPHWLAFLISVTVCFCALICVTVICYYRYKWQTERQRYHRDLEQDEAFIPAGESLKDLINQSQTSGSGSGLPLLVQRTIAKQIQTVRMIGKGRYGEVWLGRWRGEKVAVKVFFTREEASWFRETEIYQTVLMRHENILGFIAADINGTGASTQLYLITDYHENGSLYDYLKFTTLDTQALLRLAFSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGTCCIADLGLAVKFNSDTNEVDLPLSTRMGTRRYMAPEVLDETLNKNHFQAYIMADIYSYGLVIWEMARRCVTGGIVEEYQLPYYEMVPSDPSYEDMLEVVCVKGLRPTVSNRWNSDECLRAMLKLMSECWAHNPASRLTILRVKKTLAKMVESQDIKI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048589 (developmental growth), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0045165 (cell fate commitment), GO:0001704 (formation of primary germ layer), GO:0001709 (cell fate determination), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0030154 (cell differentiation), GO:0009790 (embryo development), GO:0042246 (tissue regeneration), GO:0031099 (regeneration), GO:0007492 (endoderm development), GO:0001706 (endoderm formation), GO:0001707 (mesoderm formation), GO:0007369 (gastrulation), GO:0048332 (mesoderm morphogenesis), GO:0009953 (dorsal/ventral pattern formation), GO:0007498 (mesoderm development), GO:0060795 (cell fate commitment involved in formation of primary germ layer), GO:0035987 (endodermal cell differentiation), GO:0031101 (fin regeneration), GO:0001711 (endodermal cell fate commitment)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0043235 (receptor complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0098802 (plasma membrane signaling receptor complex), GO:0098797 (plasma membrane protein complex), GO:0005886 (plasma membrane)