Protein: Voltage-dependent L-type calcium channel subunit alpha (A0A8M9Q050)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death
Subcellular location: Cell membrane, sarcolemma, T-tubule. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Membrane; Multi- pass membrane protein. Perikaryon. Postsynaptic density membrane
InterPro domains:
- IPR050599: Voltage-dependent calcium channel alpha-1 subunit (family) [97-1811]
- IPR031688: Voltage-gated calcium channel subunit alpha, C-terminal (domain) [2047-2107]
- IPR005821: Ion transport domain (domain) [157-1526]
- IPR005451: Voltage-dependent calcium channel, L-type, alpha-1C subunit (family) [43-2031]
- IPR031649: Voltage-dependent L-type calcium channel, IQ-associated domain (domain) [1536-1589]
- IPR005446: Voltage-dependent calcium channel, L-type, alpha-1 subunit (family) [185-725]
- IPR014873: Voltage-dependent calcium channel, alpha-1 subunit, IQ domain (domain) [1599-1684]
- IPR002077: Voltage-dependent calcium channel, alpha-1 subunit (family) [288-1452]
- IPR027359: Voltage-dependent channel domain superfamily (homologous_superfamily) [149-1391]
Sequence:
MLRGLFSWRRLKHERLEEEVEVRFKGKLVSERELGYTHVRPGGSNYSSPSLAPVPSLNEDEHVGGGGGVLGLAPEHIPTPGAPLSWQAAIDAARQAKLMGTTGAPISTASSTQRKRQHYTKPKKQASTASTRPPRALLCLTLKNPIRRACINIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLCHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGGTSMGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHRTCFFYKDGHKGHIAEEKPAPCAPSSAHGRHCSPPNITQCMMGWEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENDDEGLDDDKPRNLSMPASENESVNTDNAPAGDMEGETCCTRMANRISKSKFSRYSRRWNRLCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHHQQPEWLTNVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKRQNSEKPPLEDEKKEEKIELKSITSDGETPTATKINIDEYTGEDNEEKNPYPVNDFPAGEDDEEEPEMPVGPRPRPLSDIQLKEKAVPMPQAKAFFIFSPSNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTSLLQFMFACIGVQLFKGKFFYCTDTSKQTQAECRGAYILYKDGNVGKPEKAQRSWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQSQSFNKAMNILNMLFTGLFTVEMILKLIAFKPRGYFSDPWNVFDFLIVIGSIIDVILSEINPADPSSSPPSSVVRPMGLQNTEDNARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDNSQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACSPNRPCEKGSEINHSSEDCGSHFAIFYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVAKIPPKTALSLQAGLRTLHDMGPEIRRAISGDLTVEEELERAMKETVCAASEDDIFRVKRSGGLFGNHVNYYHQSDGHVSFPQSFTTQRPLHISKSGSPGEAESPSHQKLVDSTFTPSSYSSSGSNANINNANNTAIGHRYPKPTVSTVDGQTGPPLTTIPLPRPTWCFPNKRSCFYDTFMRSDSSDSRLPIIRREEASTDETYDETFLDERDQAMLSMDMLEFQDEESKQLAPMVEAEVGEERRPWQSPRRRAFLCPTALGRRSSFHLECLRKHNRPDVSQKTALPLHLVHHQALAVAGLSPLLRRSHSPTLFTRLCSTPPASPSGRSGGGPCYQPVPSLRLEGSGSYEKLNSSMPSVNCSSWYSDSNGNHSGRAQRPVSLTVPPVTRRDSISLAHGSAGSLVEAVLISEGLGRYAHDPSFIQVAKQEIAEACDMTMEEMENAADNILNANAPPNANGNLLPFIQCRDTGSQESRCSLSLGLSPATGSDGALEAELEESEGAGQRNSPLMEDEDMECVTSL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005262 (calcium channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005245 (voltage-gated calcium channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035265 (organ growth), GO:0007389 (pattern specification process), GO:0051234 (establishment of localization), GO:0051239 (regulation of multicellular organismal process), GO:0003008 (system process), GO:0048729 (tissue morphogenesis), GO:0048731 (system development), GO:0055017 (cardiac muscle tissue growth), GO:0048513 (animal organ development), GO:0044057 (regulation of system process), GO:0009799 (specification of symmetry), GO:0060419 (heart growth), GO:0003012 (muscle system process), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0006810 (transport), GO:0009790 (embryo development), GO:1904888 (cranial skeletal system development), GO:0035239 (tube morphogenesis), GO:0072001 (renal system development), GO:0060562 (epithelial tube morphogenesis), GO:0048705 (skeletal system morphogenesis), GO:0014896 (muscle hypertrophy), GO:0048562 (embryonic organ morphogenesis), GO:0003301 (physiological cardiac muscle hypertrophy), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0071702 (organic substance transport), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0006811 (monoatomic ion transport), GO:1903522 (regulation of blood circulation), GO:0009855 (determination of bilateral symmetry), GO:0048568 (embryonic organ development), GO:0003007 (heart morphogenesis), GO:0001501 (skeletal system development), GO:0060972 (left/right pattern formation), GO:0035050 (embryonic heart tube development), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0060429 (epithelium development), GO:0001822 (kidney development), GO:0007507 (heart development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0061371 (determination of heart left/right asymmetry), GO:0043009 (chordate embryonic development), GO:0007368 (determination of left/right symmetry), GO:0006812 (monoatomic cation transport), GO:0014706 (striated muscle tissue development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0048738 (cardiac muscle tissue development), GO:0048706 (embryonic skeletal system development), GO:0001947 (heart looping), GO:0008016 (regulation of heart contraction), GO:0003298 (physiological muscle hypertrophy), GO:0014897 (striated muscle hypertrophy), GO:0006816 (calcium ion transport), GO:0070509 (calcium ion import), GO:0003300 (cardiac muscle hypertrophy), GO:0030001 (metal ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0005891 (voltage-gated calcium channel complex), GO:0034703 (cation channel complex), GO:0034704 (calcium channel complex)