Protein: Acetylcholine receptor subunit alpha (P02709)
Organism: Bos taurus (Bovine)
Function: Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane
Subcellular location: Postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR006201: Neurotransmitter-gated ion-channel (family) [22-446]
- IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [24-230]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [17-235]
- IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [236-457]
- IPR002394: Nicotinic acetylcholine receptor (family) [58-146]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [238-446]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [231-447]
- IPR018000: Neurotransmitter-gated ion-channel, conserved site (conserved_site) [148-162]
Sequence:
MEPRPLLLLLGLCSAGLVLGSEHETRLVAKLFEDYNSVVRPVEDHRQAVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVVINPESDQPDLSNFMESGEWVIKESRGWKHWVFYACCPSTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPEWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAEEWKYVAMVMDHILLAVFMLVCIIGTLAVFAGRLIELNQQG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0060089 (molecular transducer activity), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0030594 (neurotransmitter receptor activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0098960 (postsynaptic neurotransmitter receptor activity), GO:0022835 (transmitter-gated channel activity), GO:0015267 (channel activity), GO:0022824 (transmitter-gated monoatomic ion channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099529 (neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential), GO:1904315 (transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0099536 (synaptic signaling), GO:0098926 (postsynaptic signal transduction), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0042391 (regulation of membrane potential), GO:1902074 (response to salt), GO:0071417 (cellular response to organonitrogen compound), GO:1901699 (cellular response to nitrogen compound), GO:1905144 (response to acetylcholine), GO:0095500 (acetylcholine receptor signaling pathway), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:1901701 (cellular response to oxygen-containing compound), GO:1902075 (cellular response to salt), GO:1905145 (cellular response to acetylcholine)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0045202 (synapse), GO:0031594 (neuromuscular junction)