lokahq/bioreason-rl huggingface dataset:
Protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X4 (A0A8M3AN70)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR001806: Small GTPase (family) [67-359]
- IPR001849: Pleckstrin homology domain (domain) [333-576]
- IPR002110: Ankyrin repeat (repeat) [744-823]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [713-829]
- IPR001164: Arf GTPase activating protein (domain) [594-717]
- IPR037278: ARFGAP/RecO-like zinc finger (homologous_superfamily) [597-709]
- IPR038508: ArfGAP domain superfamily (homologous_superfamily) [577-712]
- IPR051282: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein (family) [29-843]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [65-240]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [331-576]
Sequence:
MNSAIKVTNSTAIRAEVRRHENLQKTINKFIKQLERVEDQQLRTGLKVFLHSIQASCANSQEWTLTRTIPELRLGVLGSIRSGKSALVNRFITGSYLPLESHEGGRYKKEVLVEGQSQLLLIREESGPPSAQLCNWLDGLILVFSLENEASFQEVYKNYSELSAHRNIAEIPIIAVGTQDKISSTNARVIEDKRVQQLCIDVRRCTYYETCATYGLNVDRVFNEMTQKIVAAKKQAALLASCKSLPNSPSHSGASTPVSGPGQASNGAQSSDYPSSLPSTPVISHKDIRGGASGDGVTQRNPPRRRTSLFANRRGSDSEKRSSDSRSDTSRSVPIKQGTLWKRSERSLNKEWKKKYVTLSNSGMLTYHSNINEFLQNAQGKEMDLLRVTVKVPGKRLHRAAAPGAPSPGPALVPVPGVNGLSKDKQTPEGGAASNLLTVEEASRAGLSYPNDQKVKRCPSSVSNKGFSVDSSIEGATSPPLGKEHMPSSPMTDRKKKKRNRSINLKGDAAAGQAEAKRKMWKLKSFGSLRNINKTEEESVDFIIISSTGQSWHFEAQSQEDRDAWVQAIESQILASLQSCESRNKARRNSQSEAVALQAIRNAKGNDLCVDCAAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDVWPSELTKVLSAIGNHMANHIWETCTQGCQKLTPEATREQRESWIRAKYEQRAFVSPLPAQCSEDTMSTWLLKAVINRDLPNLLLLLAHSTKELINIPPEGAGQQHHSALHAACQLGDVVMTQLLVWYGSDVKSKDPQGRTALTLARQAGSKECAEILVQHGCPSETSPTSPTPVLSRKSSITSVGRVNSRRRVS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0007507 (heart development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Myocyte-specific enhancer factor 2A isoform X7 (A0A8M9PF89)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
Sequence:
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPDASYVLTPHTEEKYKKINEEFDNMMRNHKIPTALPPQNFSMHVAVPVTNPNAMSYNPGASLSSQSLSAAASLSDGAMLSPPQGSMHRSVVPPQRPPSTGSTGNGFVNPRGSPGLLGTPSGNGLGKVMPAKSPPPPGGNMGIGSRKPDLRVVIPPSSKGMMPPLSEEEEMELNTQRISSSQSTQPLATPVVSVTTPSLAPQGLVYSGMPTAYNSEYSLSSAELSSLQGFGSPGLSIGSVSAWQQHQLGQAALSSLVGGGHLPQGSNLSINTSQNVNIKSEPISPPRERVTPSGFPPQQQQPPSGRPDMGRSPVDSLSSSCSSYDGSDREDHRPDFHSPLGLGRPPAGGADERESPSVKRMRMDTWVT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Inositol polyphosphate 5-phosphatase K isoform X3 (A0A8M2B261)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR036691: Endonuclease/exonuclease/phosphatase superfamily (homologous_superfamily) [59-408]
- IPR046985: Inositol 5-phosphatase (family) [59-471]
- IPR000300: Inositol polyphosphate-related phosphatase (domain) [71-401]
- IPR041611: SKICH domain (domain) [405-505]
Sequence:
MSDTFDVPRMRSDSMSTMTSQSTSARFILRQRLAQLLTCLEDLSSDDEANEEVSRTLDEAFNLCGRYSNRESFRLHMVTWNVGTAEPPADVRSLLQLDSQPTTDLYVIGLQEVNATPVRYISDLIVEDTWSHLLMETLAPEGYIKVTSVRMQGLLLILFAKQVHLPFIRDIQSTYTRTGLFGYWGNKGGISVRFSFYGEMLCFLNCHLAAHMNYALQRMDEFEYILDTQEFDMFNTPQVLDHKVVFWFGDLNFRIADHGMHFLRSSINNSRFNLLWDRDQLSMLKKKEPILQEFEEGPLRFKPTYKFDRFSETYDTRAPRTWFGLTGKKRKPAWTDRILWRIKPKATEIEDEKSSTASSADDDEFSVKVTQDMYTCDVSYGVSDHKPVIGTFNLEMRKKVETPLVALTVEGIWSADEDAIFTYTILENFESSTFDWIGLYKIGFKSASDYSTFAWVKDDEVAANGEVVMVQMNKNELPLLAGDYVLGYFSTNMQTLIAFSPNFQILESKRAVMEGLVQENINGLEK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0052866 (phosphatidylinositol phosphate phosphatase activity), GO:0034595 (phosphatidylinositol phosphate 5-phosphatase activity), GO:0034594 (phosphatidylinositol trisphosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0061061 (muscle structure development), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007517 (muscle organ development), GO:0042692 (muscle cell differentiation), GO:0048880 (sensory system development), GO:0055001 (muscle cell development), GO:0060537 (muscle tissue development), GO:0007423 (sensory organ development), GO:0007519 (skeletal muscle tissue development), GO:0060538 (skeletal muscle organ development), GO:0150063 (visual system development), GO:0014904 (myotube cell development), GO:0001654 (eye development), GO:0051146 (striated muscle cell differentiation), GO:0014902 (myotube differentiation), GO:0043010 (camera-type eye development), GO:0048741 (skeletal muscle fiber development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Eukaryotic elongation factor 2 kinase (A0A8M2B2E3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR017400: Eukaryotic elongation factor 2 kinase (family) [1-725]
- IPR004166: Alpha-type protein kinase, alpha-kinase domain (domain) [142-352]
- IPR047588: Eukaryotic elongation factor 2 kinase, alpha-kinase domain (domain) [129-344]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [520-724]
- IPR051852: Alpha-type Protein Kinase (family) [133-688]
- IPR006597: Sel1-like repeat (repeat) [543-699]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [108-355]
Sequence:
MAEEELMFSMEEVGSARDGSRNRCVKNRVCFQNSNASDDDDEEDEDDLRICPITDDIISPTKGFCEFPKNLAHNQQLSNSLPKNSFTYKNKNDNIEDVRFGSLTEKGRATWKHAIEKAKAMPDPWAEFHLEEMETERCTRYRYSAITGEWAKDEIFIKVSSQTFGKGAMRECFRAKKLSNFSHSHNWKSASNYVAKRYMETVDRSVYFEDVRLQMEAKLWGEEFNRHRPPKQVDIMQMCVVEMTTRPGSPLFHLEHYIEGKYTKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTSKGTDFGDGNLGVRGMALFFHSHLCNKICRSMGLTRFDLSPAEIAQLDCTNKLLQSAKTVLRGFEEQCGSPRVRTTSLGHMPVLLSRLSETSSVDESSDTDSIPCSPLSMGVSVGRSPMGWSFMNEMNETHRSQNTEQQDSENGGDSGYPSEKRSEGDPVEHHGQLTEEKWSFYHSSRSHIHRPSCVAVEVERLNALLLEKKIGKSILGKVHLAMVRYHEAGRFCEKDEPWDQISAMYHLETAAMCGELEAIVALGQCYLQLPHHILPEIELEPSEENSQKGFRFLLQAAEAGDRPSMILVARAFDTGLKLPSDRAMDWTEAVHWYDSALKMTDYDEGGEFDGMQDEPRYLLLARLAEMYQEGGNNLDADPQRAGDLFTEAADAAMEAMKGRLANQYYMKAEEAWAMMEE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0004683 (calmodulin-dependent protein kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Leucine-rich repeat transmembrane neuronal protein 4 isoform X1 (A0A8M1Q7K6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
Sequence:
MGSLACDMRLAGLLLLQASSLLLFSSGERMCPYSCHCEGKIVHCESSAFQDVPENISVSCQGLSLRYNDLHTMLPYQFAHLNQLLWLYLDHNQIMFVDSRAFQGVRRLKELILSSNRISQLHNVTFHGVPNLRSLDLSYNKLQELQPGQFYGLRKLQNLHLRSNGLTAIPVRAFLECRSLEFLDLGYNRLRVLTRTAFLGLSRLMELHLEHNQFSRINFFLFPRLANLRALYLQWNRIRAVNQGLPWSWYTLQRLDISGNEIQVLDPVVFQCLPNLQVLNLESNKLANVSQEVVAAWISLTTISLAGNMWDCGPGICPLVVWLKNFRGTKDTNIICSSPKHLQGEKVIEASKNYIDCDDYEITAQSPLYLQTFDPNYDLALEPTEPTMAPTTPPPPLPSPASEAPFPPPQPRPPHRPTFPSRTNTDPRDSHQRTPSSFDSSLVTPVPEQDNVSFHKVVMGGVALFFSVSLVLSVIYVSCKRYPGATRLLQQSSVGRKRRKKSQEPEQNLSSQLQEYYMSYNPAATPEALEVLGNGTGTCTCTISGSRECENEYSCPRPLPGAWIGDIPTIH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065008 (regulation of biological quality), GO:0071840 (cellular component organization or biogenesis), GO:0050794 (regulation of cellular process), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0032970 (regulation of actin filament-based process), GO:0090066 (regulation of anatomical structure size), GO:0044087 (regulation of cellular component biogenesis), GO:0032535 (regulation of cellular component size), GO:1902903 (regulation of supramolecular fiber organization), GO:0033043 (regulation of organelle organization), GO:0032956 (regulation of actin cytoskeleton organization), GO:0043254 (regulation of protein-containing complex assembly), GO:0032271 (regulation of protein polymerization), GO:0110053 (regulation of actin filament organization), GO:0051493 (regulation of cytoskeleton organization), GO:0030832 (regulation of actin filament length), GO:0008064 (regulation of actin polymerization or depolymerization), GO:0030833 (regulation of actin filament polymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0008076 (voltage-gated potassium channel complex), GO:0034703 (cation channel complex), GO:0034705 (potassium channel complex)
Protein: Eukaryotic elongation factor 2 kinase (A0A8M2B219)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR017400: Eukaryotic elongation factor 2 kinase (family) [1-743]
- IPR004166: Alpha-type protein kinase, alpha-kinase domain (domain) [142-352]
- IPR047588: Eukaryotic elongation factor 2 kinase, alpha-kinase domain (domain) [129-344]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [536-742]
- IPR051852: Alpha-type Protein Kinase (family) [133-706]
- IPR006597: Sel1-like repeat (repeat) [561-717]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [108-355]
Sequence:
MAEEELMFSMEEVGSARDGSRNRCVKNRVCFQNSNASDDDDEEDEDDLRICPITDDIISPTKGFCEFPKNLAHNQQLSNSLPKNSFTYKNKNDNIEDVRFGSLTEKGRATWKHAIEKAKAMPDPWAEFHLEEMETERCTRYRYSAITGEWAKDEIFIKVSSQTFGKGAMRECFRAKKLSNFSHSHNWKSASNYVAKRYMETVDRSVYFEDVRLQMEAKLWGEEFNRHRPPKQVDIMQMCVVEMTTRPGSPLFHLEHYIEGKYTKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTSKGTDFGDGNLGVRGMALFFHSHLCNKICRSMGLTRFDLSPAEIAQLDCTNKLLSAKTVLRGFEEQCGSPRVRTTSLGHMPVLLSRLSETSSVDESSDTDSIPCSPLSMGVSVGRSPMGWSFMNEMNETHRSQNTEQQDSENGGDSGYPSEKRSEGDPVEHHGQGRPIYNRHYSESDEDSVRRLTEEKWSFYHSSRSHIHRPSCVAVEVERLNALLLEKKIGKSILGKVHLAMVRYHEAGRFCEKDEPWDQISAMYHLETAAMCGELEAIVALGQCYLQLPHHILPEIELEPSEENSQKGFRFLLQAAEAGDRPSMILVARAFDTGLKLPSDRAMDWTEAVHWYDSALKMTDYDEGGEFDGMQDEPRYLLLARLAEMYQEGGNNLDADPQRAGDLFTEAADAAMEAMKGRLANQYYMKAEEAWAMMEE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0004683 (calmodulin-dependent protein kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Regulator of G-protein signaling 3 isoform X2 (A0A8M2BGC4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR034951: Regulator of G-protein signalling 3, RGS domain (domain) [368-481]
- IPR036305: RGS domain superfamily (homologous_superfamily) [356-486]
- IPR024066: RGS, subdomain 1/3 (homologous_superfamily) [362-482]
- IPR044926: RGS, subdomain 2 (homologous_superfamily) [389-468]
- IPR016137: RGS domain (domain) [364-483]
Sequence:
MREGSRRVHSQHMPVFKMLEPKQDEPCDLRGRRMTSEDDHSLGSLSDASATTASSPQSRSLTLLEELCTSLEETCHPVPPTPPPSTEGDDGRSTESSMNEIWREEECKEKETEESDFLHAQTKDCDDCDEKQVIIDEENASEVADTNAPSSSSSFIIPELRLDRSYSADALSTPGTDEEYDEDEDDEEEEEEEDSDDNYLERSDSKRRSMVEAGSCEKHPGGLSVQNSLRRRTHSEGSLLQDPRTTCFTSDNAINCMEVSGAHKGGWTLPSPKTLKKELTKNGGSMHQLCMLFSGRKLSASSECSCDVGPDGTKKKKSKNLAKDMKNRLAFLRRRNESPGSTPASKLDKTMKSVKPTPEEAMKWGESLDKLLVHKYGLAAFRAFLRTEFSEENLDFWLACEDYKKIKSQSKMTSKAKKIFAEFIAIQSCKEVNLDSYTREHTKENLQNINRSCFELAQRRIYGLMEKDSYPRFLRSELYMDLVNQKKPSTTSTSSSS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0023057 (negative regulation of signaling), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0009790 (embryo development), GO:0030111 (regulation of Wnt signaling pathway), GO:0030178 (negative regulation of Wnt signaling pathway), GO:0061053 (somite development), GO:0060429 (epithelium development), GO:2000050 (regulation of non-canonical Wnt signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Paired box protein Pax-3 isoform X2 (A0A8M6Z8D2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
Sequence:
MTALAGGISRMMRPTPPQNYPRGGYSLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKSTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDGICDRNNVPSVSSISRMLRCKFGGNGDEDEDDDEVEKREIEENERRAKHSIDGILGDRSSHSDEGSDVDSEPGLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPSAMSSLQPYQLADSPYPPSSISQVSEQPSTVHRPQPLPPTSVHQSGLGSGPGAQEGSSAYCLSSGRHGFSGYSDGYVAAPGHANPVNPSISNGLPSQVMGLLNPGAVPHQPQSDFALSPLTGGLEPSTGMPASCHSSQRLEALPGLPSMPALPSSQSYCPSSYSSPGYSVDHVASYQYSQYGQSKVPFII
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009790 (embryo development), GO:0014029 (neural crest formation), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0060706 (cell differentiation involved in embryonic placenta development), GO:0048513 (animal organ development), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0001837 (epithelial to mesenchymal transition)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: AP-1 complex subunit mu-1 isoform X1 (A0A8M9Q618)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR011012: Longin-like domain superfamily (homologous_superfamily) [4-140]
- IPR018240: Clathrin adaptor, mu subunit, conserved site (conserved_site) [157-177]
- IPR028565: Mu homology domain (domain) [157-422]
- IPR001392: Clathrin adaptor, mu subunit (family) [3-422]
- IPR036168: AP-2 complex subunit mu, C-terminal superfamily (homologous_superfamily) [157-421]
- IPR050431: Adaptor complexes medium subunit (family) [3-421]
- IPR022775: AP complex, mu/sigma subunit (domain) [4-138]
Sequence:
MAASAIFILDLKGKVLICRNYMGNIDMNVIDNFMPIMMKREEEAELSPVVIHGSTHFLWIKHSNLYLVAMTKKNTNAALVYSFLYKLVEVFTEYFKSLEEESIRDNFVTVYELMDEVMDFGFPQTTDSKILLEYITQQGHKLEVGAPRPPATVTNAVSWRSEGIKYRKNEVFMDVIESVNLLVSATGSVLRSEILGCIKLKVVLSGMPELRLGLNDKVLFEITGREKTKSVELEDVKFHQCVRLSRFENDRTISFIPPDGESELMSYRLNTTVKPLIWIESVIEKFSHSRVEIKVKARSQFKSRSTANNVSILVPVPSDADSPKFKTTTGQAKWVPEKSAVEWNIKSFPGGKEFMMRAHFGLPSVESDELEGKRPITVKFEIPYFTVSGIQVRYLKIIEKSGYQALPWVRYITQSGDYQLRTN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)