lokahq/bioreason-rl huggingface dataset:
Protein: Filaggrin (A6KMN2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasmic granule
InterPro domains:
- IPR001751: S100/Calcium binding protein 7/8-like, conserved site (conserved_site) [57-78]
- IPR034325: S-100 (domain) [2-87]
- IPR011992: EF-hand domain pair (homologous_superfamily) [1-90]
- IPR052503: S100-fused Epidermal Structural Protein (family) [1-249]
- IPR013787: S100/CaBP-9k-type, calcium binding, subdomain (domain) [4-48]
- IPR002048: EF-hand domain (domain) [49-84]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [62-74]
Sequence:
MSTLLESITSMIDIFQQYSNNDKEEETLSKEELKELLEGELQAVLKNPNDQDIAEVFMQMLDVDHDDKIDFTEYLLMVLKLAQAYYETSKKRRSQTKESGKRNEHDYKGYEERREKVQRRHRRRNSGTDGKQENERSKSPRGRGNKRRGSSTISEESDTNRNSDTENKRHHHGSNRRQRRGSNSSDRKETRSKKHREVKERNAGIYNDGKDGQDWEVNYENCYYKTEESNREQREGRNHKTKESHSESEASGGQAGRRGTAATRHTSRPEQSPDTAGRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASASQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0060429 (epithelium development), GO:0008544 (epidermis development), GO:0030855 (epithelial cell differentiation), GO:0009913 (epidermal cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane), GO:0001533 (cornified envelope)
Protein: Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (P70554)
Organism: Rattus norvegicus (Rat)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein. Membrane; Single-pass type II membrane protein
InterPro domains:
- IPR050943: Glycosyltransferase 29 (Sialyltransferase) (family) [63-347]
- IPR001675: Glycosyl transferase family 29 (family) [93-337]
- IPR038578: GT29-like superfamiliy (homologous_superfamily) [65-347]
- IPR012163: Sialyltransferase (family) [62-347]
Sequence:
MSPGGGPLHTSRGAMAMLGGKFPRTRLPVGASALCVVVLCWLYVFPVYRLPNEKEIVQGVLAQRTAWRRNQTSARLFRKQMEDCCNPAHLFAMTKVNSPMGKSLWYDGEFLYSLTIDTSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKDAGANQTVLFANPNFLRNIGKFWKGRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGEPISHHYYDNVLPFSGFHAMPEEFLQLWYLHKMGALRMQLDPCENPPPSRHHSPPS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0008373 (sialyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0070085 (glycosylation), GO:0044249 (cellular biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043413 (macromolecule glycosylation), GO:1901135 (carbohydrate derivative metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0006486 (protein glycosylation), GO:0043412 (macromolecule modification), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0009100 (glycoprotein metabolic process), GO:0009101 (glycoprotein biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0000139 (Golgi membrane)
Protein: Procollagen, type V, alpha 2 (A6INT3)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR001007: VWFC domain (domain) [38-96]
- IPR000885: Fibrillar collagen, C-terminal (domain) [1264-1498]
- IPR008160: Collagen triple helix repeat (repeat) [212-1226]
- IPR050938: Collagen and Collagen-like Structural Proteins (family) [602-1157]
Sequence:
MMANWVVARPLLILFVLLGYCVSIKAQEQENDDYDEEIACTQHGQMYLNRDIWKPSPCQICVCDNGAILCDKIECQEVLNCANPVTPPGECCPACPQTSGGGDTSFGRGRKGQKGEPGLVPVVTGIRGRPGPAGPPGSQGPRGDRGPKGRPGPRGPQGIDGEPGVPGQPGAPGPPGHPSHPGPDGMSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPIGPRGPQGLQGQQGGVGPAGPPGEPGEPGPMGPIGARGPEGPPGKPGEDGEPGRNGNTGEVGFSGSPGARGFPGAPGLPGLKGHRGNKGLEGPKGEVGAPGAKGEAGPTGPMGAMGPLGPRGMPGERGRLGPQGAPGQRGAHGMPGKPGPMGPLGIPGSSGFPGNPGVKGEAGPTGARGPEGPQGQRGETGPPGPAGSHGLPGAVGTDGTPGAKGPTGSPGTSGPPGLAGPPGSPGPQGSTGPQGIRGQLGDPGVPGFKGEAGPKGEPGPHGIQGPIGPPGEEGKRGPRGDPGTVGPPGPMGERGAPGNRGFPGSDGLPGPKGAQGERGPIGSSGPKGGQGDPGRPGEPGLPGARGLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQPGSMGLPGPKGSSGDLGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGFQGLPGPPGPPGEGGKPGDQGVPGEPGAVGPLGPRGERGNPGERGEPGITGLPGEKGMAGGHGPDGPKGNPGPTGTIGDTGPPGLQGMPGERGIAGTPGPKGDRGGVGEKGAEGTAGNDGARGLPGSLGPPGPAGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPHGVPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPIGEPGKEGPPGLRGDPGSHGRVGDRGPAGPPGSPGDKGDPGEDGQPGPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGATGDKGPPGPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGTPGPVGAPGDAGQRGEPGSRGPVGPPGRAGKRGLPGPQGPRGDKGDNGDRGDRGQKGHRGFTGLQGLPGPPGPNGEQGSAGIPGPFGPRGPPGPVGPSGKEGNPGLLGPIGPPGVRGSVGEAGPEGPPGEPGPPGPPGPPGHLTAALGDIMGHYDENMPDPLPEFTEDQAAPDDTNKTDPGVHATLKSLSSQIETMRSPDGSKKHPARTCDDLKLCHPTKQSGEYWIDPNQGSAEDAIKVYCNLETGETCISANPASVPRKTWWASKSPDNKPVWYGLDMNRGSQFTYGDYKSPNTAITQMTFLRLLSKEASQNLTYICKNTVGYMDDQTKNLKKAVVLKGSNDLEIKGEGNIRFRYTVLQDTCSKRNGNVGKTVFEYRTQNVARLPIIDIGPVDIGNADQEFGFEIGPVCFM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005201 (extracellular matrix structural constituent)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0001503 (ossification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0099080 (supramolecular complex), GO:0071944 (cell periphery), GO:0005581 (collagen trimer), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0098644 (complex of collagen trimers), GO:0005583 (fibrillar collagen trimer), GO:0099081 (supramolecular polymer), GO:0062023 (collagen-containing extracellular matrix), GO:0098643 (banded collagen fibril), GO:0099512 (supramolecular fiber)
Protein: RCG35840 (A6IJW1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell projection, cilium membrane. Membrane
InterPro domains:
- IPR026501: Limbin/EvC complex member EVC (family) [99-962]
Sequence:
MTCRRDARLQLGREALQAAPTLLVPAVLLGALLGLGLGLWLGCRARRLRARLQKDDTKHLLRSSEPPAQSLRDTSSKARRRQRETTRDEDAPEVCEPSLSGNITAFALKARVVYPINQKFRPLADGSSHPSLHENLTQAAAILPHLPHQPAEASPASSLGSLSQAGKEDGSSSSSMQSTYSDDRVLQCAFLRVGSFPEILAYESVDIDLCVCSLHLKDLLQVDAALRQEKHLMFLQILKACLLECFPKKKPEEELYQKILSKQEHDLEELEKGLQARLANTEMLGTGDSGYISLADVERKERELSEQLIDNMGAFWKQMESMQPILMDQLKCSSSKARQLMMTLTGRMIVAEGLLHESQDLHVLDTLERTMGRAHMARIVEFLRTQIQEETKCRLAAISRGLELLTVQGQLSGRQKEELLTQQHKAFWEEAECFGREFMQRGKDLVQVSQAHRAEAVAELTRAQEEERRIFLADTQPTSDPEEFLKAFHEVLERQRLTRSDQEGEEDTRITEAMAALCQELYCGTMETFQKFVDTLFLKTLPEVSSLPVAECEALRQQVQEQAARQLGQADRFRRRQWGLLCDLLEQDKRVWLEECTLSTVLQRQLRDHHESTIHGVLSRFSGLSEESTRGILQGHELLLCSALRRLALRGTTITALAQMRLSGKKRLLQELHEQLALEQGVSPCLEEHQWQLLRALEARILEETARLEDEAQQTALRLQQQLLAEAQEAGQLLQLHSERAIGQALLVHARNVASKGRTRDKEDFKRTLVETVVESVYVTSTSVNRLVQVHYQGIGKLLQAHEEQLLQRLKTLQDERINAYKLWKKQEFSDPPSESQTPGGTHGAPQAVQQRMTSQRKKLLDQFTKHQQGRLNSQRQKAQELDQLEAQLETQLQEAEQTLISELATLARVPLAENKPFSNKRGLPEKPVRTKRKKPPPREREDLGLPNDDHPALADHSTGPLSAVYSASPPILVHSNGKLGQQDGEACDGENTRKILQKRSNL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009888 (tissue development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0001501 (skeletal system development), GO:0051216 (cartilage development), GO:0061448 (connective tissue development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0031090 (organelle membrane), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0031253 (cell projection membrane), GO:0005929 (cilium), GO:0098588 (bounding membrane of organelle), GO:0060170 (ciliary membrane)
Protein: BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP2 (Predicted), isoform CRA_d (A6KEV4)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR022181: Bcl2-/adenovirus E1B 19kDa-interacting protein 2 (family) [50-163]
- IPR036865: CRAL-TRIO lipid binding domain superfamily (homologous_superfamily) [145-301]
- IPR001251: CRAL-TRIO lipid binding domain (domain) [147-301]
Sequence:
MEGVELKEEWQDEDFPIPLPEDDSIEADILDVTDPDRQPGSLEVNGNKVRKKLVAPDISLTLDPGEDSLWSDDLDEGGEVDLDGLDTPSENSDEFEWEDDLPKPKTTEVIRKGSITEYAATEEKEDGRRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYYGDGLNAIVVFAVCFMPESGQPNYRYLMDNLFKYVIGTLELLVAENYMIIYLNGATTRRKMPSLGWLRRCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVFNLAELAELVPMEYVGIPECIKQCVSLLCFSSWIWARGLLLCLTVLKNTGL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0009991 (response to extracellular stimulus), GO:0070482 (response to oxygen levels), GO:0031667 (response to nutrient levels), GO:0036293 (response to decreased oxygen levels), GO:0090649 (response to oxygen-glucose deprivation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0044306 (neuron projection terminus), GO:0042995 (cell projection), GO:0036477 (somatodendritic compartment), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0045202 (synapse), GO:0043005 (neuron projection), GO:0030425 (dendrite), GO:0030424 (axon)
Protein: RCG59320, isoform CRA_a (A6K7K4)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR003527: Mitogen-activated protein (MAP) kinase, conserved site (conserved_site) [59-162]
- IPR008352: Mitogen-activated protein (MAP) kinase HOG-like (family) [12-317]
- IPR000719: Protein kinase domain (domain) [24-308]
- IPR050117: Mitogen-activated protein (MAP) kinase (family) [23-319]
- IPR017441: Protein kinase, ATP binding site (binding_site) [30-54]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [10-347]
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAVDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLETSQLPGTHEIEQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016740 (transferase activity), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0140096 (catalytic activity, acting on a protein), GO:0097367 (carbohydrate derivative binding), GO:1901265 (nucleoside phosphate binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0032555 (purine ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0005524 (ATP binding), GO:0032559 (adenyl ribonucleotide binding), GO:0004707 (MAP kinase activity), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0006468 (protein phosphorylation), GO:0016310 (phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Vesicle-associated membrane protein 4 (Predicted), isoform CRA_b (A6ID95)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single- pass type IV membrane protein
InterPro domains:
- IPR001388: Synaptobrevin-like (family) [57-132]
- IPR042855: v-SNARE, coiled-coil homology domain (domain) [52-132]
- IPR042887: Vesicle-associated membrane protein 4 (family) [1-141]
Sequence:
MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALAAAILLLMIIILIVVKYRT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0005515 (protein binding), GO:0000149 (SNARE binding), GO:0005484 (SNAP receptor activity), GO:0019905 (syntaxin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0060627 (regulation of vesicle-mediated transport), GO:0051049 (regulation of transport), GO:0046907 (intracellular transport), GO:0051128 (regulation of cellular component organization), GO:0006810 (transport), GO:0030100 (regulation of endocytosis), GO:0016192 (vesicle-mediated transport), GO:0016197 (endosomal transport), GO:0006996 (organelle organization), GO:0010256 (endomembrane system organization), GO:1903421 (regulation of synaptic vesicle recycling), GO:1900242 (regulation of synaptic vesicle endocytosis), GO:0016050 (vesicle organization), GO:0048284 (organelle fusion), GO:0099532 (synaptic vesicle endosomal processing), GO:0007032 (endosome organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0098796 (membrane protein complex), GO:0030054 (cell junction), GO:0031984 (organelle subcompartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031201 (SNARE complex), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0045202 (synapse), GO:0098791 (Golgi apparatus subcompartment), GO:0005794 (Golgi apparatus), GO:0043227 (membrane-bounded organelle), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0005802 (trans-Golgi network), GO:0010008 (endosome membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0045335 (phagocytic vesicle)
Protein: RCG37275, isoform CRA_b (A6KI03)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR005024: Snf7 family (family) [6-198]
Sequence:
MSVFGKLFGAGGGKAGKGGPTPQEAIQRLRDTEEMLSKKQEFLEKKIEQELTAAKKHGTKNKRAALQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTNTEVLKNMGYAAKAMKAAHDNMDIDKVDELMQDIADQQELAEEISTAISKPVGFGEEFDEDELMAELEELEQEELDKNLLEISGPETVPLPNVPSVALPSKP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0050807 (regulation of synapse organization), GO:0099175 (regulation of postsynapse organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0098794 (postsynapse), GO:0030054 (cell junction), GO:0045202 (synapse), GO:0099572 (postsynaptic specialization), GO:0098984 (neuron to neuron synapse), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0032279 (asymmetric synapse)
Protein: H/ACA ribonucleoprotein complex subunit 2 (M0RCV4)
Organism: Rattus norvegicus (Rat)
Function: Common component of the spliceosome and rRNA processing machinery
Subcellular location: Nucleus, nucleolus
InterPro domains:
- IPR018492: Ribosomal protein eL8/Nhp2 family (family) [60-119]
- IPR004038: Ribosomal protein eL8/eL30/eS12/Gadd45 (domain) [46-138]
- IPR029064: Ribosomal protein eL30-like superfamily (homologous_superfamily) [25-149]
- IPR002415: H/ACA ribonucleoprotein complex, subunit Nhp2-like (family) [33-119]
- IPR050257: Large ribosomal subunit protein eL8/uL1-like (family) [31-144]
Sequence:
MTKIKVVPEESEAQAEGCSEERTYEELLVNLNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVMCEDQNLPYVYIPSKTDLGAATGSKRPTCVIMVKPHEDYQEAYDKCLEEVQALPTPL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0003006 (developmental process involved in reproduction), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0007548 (sex differentiation), GO:0046661 (male sex differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0008406 (gonad development), GO:0046546 (development of primary male sexual characteristics), GO:0061458 (reproductive system development), GO:0008584 (male gonad development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Caspase 7, isoform CRA_d (A6JI22)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR001309: Peptidase C14, p20 domain (domain) [64-188]
- IPR016129: Peptidase family C14A, His active site (active_site) [129-143]
- IPR002138: Peptidase C14, caspase non-catalytic subunit p10 (domain) [207-301]
- IPR002398: Peptidase C14 family (family) [38-299]
- IPR029030: Caspase-like domain superfamily (homologous_superfamily) [56-299]
- IPR011600: Peptidase C14, caspase domain (domain) [66-298]
- IPR033139: Peptidase family C14A, cysteine active site (active_site) [175-186]
- IPR015917: Peptidase C14A, caspase catalytic domain (domain) [57-301]
Sequence:
MLSFYYYREEGNSLPVASGGSLVLQRGLLPDGDTRKKKKNASMCPVSTTRDRVPTYLYRMDFEKMGKCIIINNKNFDKATGMDVRNGTDKDAEALFKCFRSLGFEVTVYNDCSCAKMQDLLRRASEEDHSNSACFACVLLSHGEENLIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRNPGKGSWFVQALCSILNEHGKDLEIMQILTRVNDRVARHFESQSDDPRFNEKKQIPCMVSMLTKELYFGR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0007568 (aging), GO:0009056 (catabolic process), GO:0008219 (cell death), GO:0006807 (nitrogen compound metabolic process), GO:0061061 (muscle structure development), GO:0012501 (programmed cell death), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0030154 (cell differentiation), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0042692 (muscle cell differentiation), GO:0030163 (protein catabolic process), GO:0006915 (apoptotic process), GO:0071887 (leukocyte apoptotic process), GO:0051146 (striated muscle cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)