Protein: MCL1 apoptosis regulator, BCL2 family member (A0A7I2V2W2)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm. Nucleus, nucleoplasm
InterPro domains:
- IPR020717: Apoptosis regulator, Bcl-2, BH1 motif, conserved site (conserved_site) [55-74]
- IPR020726: Apoptosis regulator, Bcl-2, BH2 motif, conserved site (conserved_site) [107-118]
- IPR026298: Bcl-2 family (family) [4-142]
- IPR020728: Apoptosis regulator, Bcl-2, BH3 motif, conserved site (conserved_site) [11-25]
- IPR002475: Bcl2-like (family) [15-116]
- IPR036834: Bcl-2-like superfamily (homologous_superfamily) [1-128]
- IPR013281: Apoptosis regulator, Mcl-1 (family) [38-152]
- IPR046371: Bcl-2, Bcl-2 homology region 1-3 (domain) [15-114]
Sequence:
MGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0019904 (protein domain specific binding), GO:0097718 (disordered domain specific binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0023056 (positive regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007165 (signal transduction), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010942 (positive regulation of cell death), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0012501 (programmed cell death), GO:0060548 (negative regulation of cell death), GO:0080134 (regulation of response to stress), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0031324 (negative regulation of cellular metabolic process), GO:0038034 (signal transduction in absence of ligand), GO:0010033 (response to organic substance), GO:0009894 (regulation of catabolic process), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0097190 (apoptotic signaling pathway), GO:0010647 (positive regulation of cell communication), GO:0007166 (cell surface receptor signaling pathway), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:1901216 (positive regulation of neuron death), GO:0034097 (response to cytokine), GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0031330 (negative regulation of cellular catabolic process), GO:1903209 (positive regulation of oxidative stress-induced cell death), GO:2001235 (positive regulation of apoptotic signaling pathway), GO:0010506 (regulation of autophagy), GO:1901214 (regulation of neuron death), GO:2001234 (negative regulation of apoptotic signaling pathway), GO:2001233 (regulation of apoptotic signaling pathway), GO:2001020 (regulation of response to DNA damage stimulus), GO:1900407 (regulation of cellular response to oxidative stress), GO:1901099 (negative regulation of signal transduction in absence of ligand), GO:0010507 (negative regulation of autophagy), GO:1903201 (regulation of oxidative stress-induced cell death), GO:1902882 (regulation of response to oxidative stress), GO:0006915 (apoptotic process), GO:1902533 (positive regulation of intracellular signal transduction), GO:0097191 (extrinsic apoptotic signaling pathway), GO:0031329 (regulation of cellular catabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0043065 (positive regulation of apoptotic process), GO:2001242 (regulation of intrinsic apoptotic signaling pathway), GO:0042981 (regulation of apoptotic process), GO:1902175 (regulation of oxidative stress-induced intrinsic apoptotic signaling pathway), GO:2001239 (regulation of extrinsic apoptotic signaling pathway in absence of ligand), GO:1903203 (regulation of oxidative stress-induced neuron death), GO:0043066 (negative regulation of apoptotic process), GO:0043523 (regulation of neuron apoptotic process), GO:2001244 (positive regulation of intrinsic apoptotic signaling pathway), GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway), GO:2001240 (negative regulation of extrinsic apoptotic signaling pathway in absence of ligand), GO:2001236 (regulation of extrinsic apoptotic signaling pathway), GO:0043525 (positive regulation of neuron apoptotic process), GO:2000209 (regulation of anoikis), GO:2000811 (negative regulation of anoikis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)