Protein: RING-type E3 ubiquitin transferase (A0A8I5KPE0)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton
InterPro domains:
- IPR003649: B-box, C-terminal (domain) [219-345]
- IPR050617: E3 ubiquitin-protein ligases and FN3/SPRY domain-containing proteins (family) [28-419]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [381-464]
- IPR047095: Midline-1, B-box-type 1 zinc finger (domain) [115-164]
- IPR040859: Midline-1, COS domain (domain) [323-374]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [25-34]
- IPR027727: Midline-1, B-box-type 2 zinc finger (domain) [168-214]
- IPR000315: B-box-type zinc finger (domain) [114-212]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [1-91]
- IPR017903: COS domain (domain) [320-379]
- IPR027370: Zinc finger, RING-type, eukaryotic (domain) [10-57]
- IPR001841: Zinc finger, RING-type (domain) [10-60]
Sequence:
METLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNESVESITAFQCPTCRHVITLSQRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSETRRERAFDANTMTSAEKVLCQFCDQDPAQDAVKTCVTCEVSYCDECLKATHPNKKPFTGHRLIEPIPDSHIRGLMCLEHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSERYDKLKQNLESNLTNLIKRNTELETLLAKLIQTCQHVEVNASRQEAKLTEECDLLIEIIQQRRQIIGTKIKEGKVMRLRKLAQQIANCKQCIERSASLISQAEHSLKENDHARFLQTAKNITERVSMATASSQVLIPEINLNDTFDTFALDFSREKKLLECLDYLTAPNPPTIREELCTASYDTITVHWTSDDEFSVVSYELQYTIFTGQANVVSEYLMAYLFLSLVAFFRLIAFLNLNFKGRQGRKEHTIFIDLSFLNKKVIALTCTTLVKTAG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0046983 (protein dimerization activity), GO:0042802 (identical protein binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0051219 (phosphoprotein binding), GO:0042803 (protein homodimerization activity), GO:0044389 (ubiquitin-like protein ligase binding), GO:0015631 (tubulin binding), GO:0031625 (ubiquitin protein ligase binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0051129 (negative regulation of cellular component organization), GO:0032886 (regulation of microtubule-based process), GO:0051128 (regulation of cellular component organization), GO:1902903 (regulation of supramolecular fiber organization), GO:0010639 (negative regulation of organelle organization), GO:0033043 (regulation of organelle organization), GO:0043242 (negative regulation of protein-containing complex disassembly), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:1902904 (negative regulation of supramolecular fiber organization), GO:0043244 (regulation of protein-containing complex disassembly), GO:0031110 (regulation of microtubule polymerization or depolymerization), GO:0031114 (regulation of microtubule depolymerization), GO:0007026 (negative regulation of microtubule depolymerization), GO:0051493 (regulation of cytoskeleton organization), GO:1901880 (negative regulation of protein depolymerization), GO:0051494 (negative regulation of cytoskeleton organization), GO:0031111 (negative regulation of microtubule polymerization or depolymerization), GO:1901879 (regulation of protein depolymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0034451 (centriolar satellite), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)