Protein: Histone deacetylase (A6HJH3)
Organism: Rattus norvegicus (Rat)
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events
Subcellular location: Nucleus
InterPro domains:
- IPR023696: Ureohydrolase domain superfamily (homologous_superfamily) [673-1053]
- IPR000286: Histone deacetylase HDAC (family) [820-955]
- IPR046949: Histone deacetylase 4/5/7/9 (family) [25-1113]
- IPR023801: Histone deacetylase domain (domain) [695-1013]
- IPR037138: Histone deacetylase domain superfamily (homologous_superfamily) [671-1057]
- IPR024643: Histone deacetylase, glutamine rich N-terminal domain (domain) [67-155]
Sequence:
MNSPNESDGMSGREPSLEILPRTPLHSIPVAVEVKPVLPAAMPSSMGGGGGGSPSPVELRGALAGPMDPALREQQLQQELLVLKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLLGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGTGPGVSSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGSTLTGKFMSTSSIPGCLLGVALEGDTSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQMQLGKILTKTGELSRQPTTHPEETEEELTEQQEALLGEGALTMPREGSTESESTQEDLEEEEDEEEDEEDCIQVKDEDGESGPDEGADLEESSAGYKKLFADAQQLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGSMKSPTDHPTVVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAMLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLVELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLSVGKVLIVDWDIHHGNGTQQAFYDDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPSVNAVATLEKVIEIQSKHWSCVQRFATGLGCSLREAQTGEKEEAETVSAMALLSMGAEQAQAAATQEHSPRPAEEPMEQEPAL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0014823 (response to activity), GO:0051707 (response to other organism), GO:0043207 (response to external biotic stimulus), GO:1901698 (response to nitrogen compound), GO:0009410 (response to xenobiotic stimulus), GO:0030154 (cell differentiation), GO:0070887 (cellular response to chemical stimulus), GO:0048731 (system development), GO:0009617 (response to bacterium), GO:0016043 (cellular component organization), GO:1901700 (response to oxygen-containing compound), GO:0071216 (cellular response to biotic stimulus), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0022008 (neurogenesis), GO:0071219 (cellular response to molecule of bacterial origin), GO:0042220 (response to cocaine), GO:0032496 (response to lipopolysaccharide), GO:0007399 (nervous system development), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0002237 (response to molecule of bacterial origin), GO:0006325 (chromatin organization), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0030182 (neuron differentiation), GO:0071222 (cellular response to lipopolysaccharide), GO:0043279 (response to alkaloid), GO:0048699 (generation of neurons), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)