Protein: G-protein coupled receptor family C group 6 member A (Q8K4Z6)
Organism: Mus musculus (Mouse)
Function: Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations. Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+) . Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Mediates the non-genomic effects of androgens in multiple tissue . May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR017979: GPCR, family 3, conserved site (conserved_site) [541-565]
- IPR011500: GPCR, family 3, nine cysteines domain (domain) [519-570]
- IPR038550: GPCR, family 3, nine cysteines domain superfamily (homologous_superfamily) [518-595]
- IPR017978: GPCR family 3, C-terminal (domain) [587-855]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [29-495]
- IPR000337: GPCR, family 3 (family) [33-802]
- IPR001828: Receptor, ligand binding region (domain) [75-481]
- IPR000068: GPCR, family 3, extracellular calcium-sensing receptor-related (family) [30-853]
Sequence:
MALLITVVTCFMIILDTSQSCHTPDDFVAITSPGHIMIGGLFAIHEKMLSSDDHPRRPQIQKCAGFEISVFLQTLAMIHSIEMINNSTLLSGVKLGYEIYDTCTEVTAAMAATLRFLSKFNCSRETVVFQCDYSSYMPRVKAVIGAGYSETSIAVSRMLNLQLMPQVSYESTAEILSDKIRFPSFLRTVPSDFYQTKAMAHLIRQSGWNWIGAITTDDDYGRLALNTFAIQAAENNVCIAFKEVLPAFLSDNTIEVRINQTLEKIIAEAQVNVIVVFLRKFHVFNLFTKAIERKISKIWIASDNWSTATKIITIPNVKKLGKVVGFAFRRGNTSSFHSFLQTLHMYPNDNNKPLHEFAMLVSACKYIKDGDLSQCISNYSQATLTYDTTKTIENHLFKRNDFLWHYTEPGLIYSIQLAVFALGHAIRDLCQARDCKKPNAFQPWELLAVLKNVTFTDGRNSFHFDAHGDLNTGYDVVLWKETNGLMTVTKMAEYDLQRDVFITTNQETKHEFRKLKQILSKCSKECSPGQMKKATGSQHSCCYECVSCPENHYSNETDMDHCLLCNNETHWAPVRSTTCFEKEVEYLDWDDSLALLLIALSLLGIAFVLAIGIIFTRNLKTPVVKSSGGLVVCYVMLICHALNFASTGFFIGEPQDFACKTRQTLFGVSFTLCVSCILTKSLKILLAFSFDPKLTMFLKCLYRPVPIVLTCTGIQVVICTLWLVLAAPSVEENISLPRVIILECEEGSALAFGTMLGYITVLAFICFVFAFKGRKLPENYNEAKFLTFGMLIYFIAWITFIPVYTTTFGKYLPAVEIIVILISNYGILCCIFFPKCYIILCKQKTNTKSAFLQMVYNYSAHSVDSLALSHVSLDSTSYDTATTNQSPGNKMTACQNDNHLPAQVLPHTGTAKTIKASKTLRQKRSSSI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0004984 (olfactory receptor activity), GO:0038022 (G protein-coupled olfactory receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0001101 (response to acid chemical), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0043200 (response to amino acid), GO:0010243 (response to organonitrogen compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)