Protein: adenylate cyclase (A6KDA2)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR009398: Adenylate cyclase, conserved domain (domain) [487-593]
- IPR029787: Nucleotide cyclase (homologous_superfamily) [218-1091]
- IPR032628: Adenylate cyclase, N-terminal (domain) [19-251]
- IPR001054: Adenylyl cyclase class-3/4/guanylyl cyclase (domain) [226-1087]
- IPR018297: Adenylyl cyclase class-4/guanylyl cyclase, conserved site (conserved_site) [1020-1043]
- IPR030672: Adenylate cyclase (family) [14-1094]
Sequence:
MPAKGRYFLNEGDEGPKQAALYEKYRLTSQHGPLLLLLLLVAVATCIALVSIVFSHEDLRRHQAVLGTAFFMLTLFVALYVLVYVECLAQRWLRVLALLTWACLMILGSVLMWDSLENEAYAWEQVPFFLFIVFVVYVLLPLSTRAAIAVGVASTISHLLVFGAVTRAFKTSMSSTQLGLQLLANAVILLGGNFTGAFHKHQLQDASRDLFIYTVKCIQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIERLKEGGDRHYTPDNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGEQRDPYLKEMNIRTYLVIDPRSQQPPLPSHHLSKPKGDATLKMRASVRVTRYLESWGAARPFAHLNHRESVSSSEIPIPNGRRQKAIPLRRHRAPDRSASPKGRLEDDCDDEMLSAIEGLSSTRPCCSKSDDFHTFGPIFLEKGFEREYRLVPIPRARYDFACASLVFVCILLVHLLVMPRMATLGLSFGLVACLLGLVLSFCFATEFSRCLPARSTLQAISESVETQPLLRLSLVVVTVGSLLTVAIINMPLTFNPGPEQPGDNETSPLAARNRVGTPCELLPYYTCSCVLGFIACSVFLRMSLELKAMLLTVALVAYLLLFNLSPCWQVSGNSTETNSTHRTRRLLSAEQSMNSHTLALGAQMTAPSPSSCLERDLKTMINFYLVLFYATLILLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKAAEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVPSGHENQDLERKHVHIGVLVEFSMALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0009975 (cyclase activity), GO:0004016 (adenylate cyclase activity), GO:0016849 (phosphorus-oxygen lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0044706 (multi-multicellular organism process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044703 (multi-organism reproductive process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0007565 (female pregnancy), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0060135 (maternal process involved in female pregnancy), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0009259 (ribonucleotide metabolic process), GO:0009117 (nucleotide metabolic process), GO:0046390 (ribose phosphate biosynthetic process), GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0052652 (cyclic purine nucleotide metabolic process), GO:0009165 (nucleotide biosynthetic process), GO:0006164 (purine nucleotide biosynthetic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009260 (ribonucleotide biosynthetic process), GO:0009187 (cyclic nucleotide metabolic process), GO:0009152 (purine ribonucleotide biosynthetic process), GO:0046058 (cAMP metabolic process), GO:0009190 (cyclic nucleotide biosynthetic process), GO:0006171 (cAMP biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)