lokahq/bioreason-rl huggingface dataset:
Protein: ELAV-like protein 1 isoform X2 (A0A8M3AQB0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR000504: RNA recognition motif domain (domain) [1-206]
- IPR002343: Paraneoplastic encephalomyelitis antigen (family) [10-68]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [1-208]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [1-210]
Sequence:
MTQKDVEEMFGRYGRIINSRVLVDQASGLSRGVAFIRFDKRAEAEDAIKDLNGQKPPGAAEQMTVKFAASPNQVKNTQVIPQVYHQQSRRFGGPVHHQAQRFRFSPMSVDHMSGMSGVNVPGNSSSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTHYEEAAMAIASLNGYRLGDKILQVSFKTSKSHK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0050793 (regulation of developmental process), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0048871 (multicellular organismal-level homeostasis), GO:0002262 (myeloid cell homeostasis), GO:0051240 (positive regulation of multicellular organismal process), GO:1904018 (positive regulation of vasculature development), GO:2000026 (regulation of multicellular organismal development), GO:0034101 (erythrocyte homeostasis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0048872 (homeostasis of number of cells), GO:1901342 (regulation of vasculature development), GO:0045766 (positive regulation of angiogenesis), GO:0030097 (hemopoiesis), GO:0045765 (regulation of angiogenesis), GO:0030218 (erythrocyte differentiation), GO:0030099 (myeloid cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Eukaryotic elongation factor 2 kinase (A0A8M2B2Y1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR017400: Eukaryotic elongation factor 2 kinase (family) [1-725]
- IPR004166: Alpha-type protein kinase, alpha-kinase domain (domain) [123-333]
- IPR047588: Eukaryotic elongation factor 2 kinase, alpha-kinase domain (domain) [110-325]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [518-724]
- IPR051852: Alpha-type Protein Kinase (family) [49-688]
- IPR006597: Sel1-like repeat (repeat) [543-699]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [85-336]
Sequence:
MAEEELMFSMEEVGSARDGSRNRCVKNRVCFQNSNASDDDDEEDEDDLRICPITDDIISPTKGFCEFPKNLAHNQQLSNSLPKNSFTYKATWKHAIEKAKAMPDPWAEFHLEEMETERCTRYRYSAITGEWAKDEIFIKVSSQTFGKGAMRECFRAKKLSNFSHSHNWKSASNYVAKRYMETVDRSVYFEDVRLQMEAKLWGEEFNRHRPPKQVDIMQMCVVEMTTRPGSPLFHLEHYIEGKYTKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTSKGTDFGDGNLGVRGMALFFHSHLCNKICRSMGLTRFDLSPAEIAQLDCTNKLLQSAKTVLRGFEEQCGSPRVRTTSLGHMPVLLSRLSETSSVDESSDTDSIPCSPLSMGVSVGRSPMGWSFMNEMNETHRSQNTEQQDSENGGDSGYPSEKRSEGDPVEHHGQGRPIYNRHYSESDEDSVRRLTEEKWSFYHSSRSHIHRPSCVAVEVERLNALLLEKKIGKSILGKVHLAMVRYHEAGRFCEKDEPWDQISAMYHLETAAMCGELEAIVALGQCYLQLPHHILPEIELEPSEENSQKGFRFLLQAAEAGDRPSMILVARAFDTGLKLPSDRAMDWTEAVHWYDSALKMTDYDEGGEFDGMQDEPRYLLLARLAEMYQEGGNNLDADPQRAGDLFTEAADAAMEAMKGRLANQYYMKAEEAWAMMEE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0004683 (calmodulin-dependent protein kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Stress-activated protein kinase JNK (A0A8M1P270)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity
Subcellular location: Cytoplasm
InterPro domains:
- IPR003527: Mitogen-activated protein (MAP) kinase, conserved site (conserved_site) [99-201]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [185-197]
- IPR000719: Protein kinase domain (domain) [64-359]
- IPR050117: Mitogen-activated protein (MAP) kinase (family) [62-385]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [52-381]
- IPR008351: Mitogen-activated protein (MAP) kinase, JNK (family) [114-373]
Sequence:
MNRRFLYNCSAPVLDVKIAFCQGFGKQVDVSYIAQHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAGYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPSPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDCLFPADSEHNKLKASQARDLLSKMLIIDPAKRISVDEALQHPYINVWYDPAEVEAARNQQISMPPPQIYDKQLDEREHSIDEWKELIYKEVMNFEERTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLETSAGPLGCCRXLTACLRNPMFFRR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0048483 (autonomic nervous system development), GO:0007399 (nervous system development), GO:0061008 (hepaticobiliary system development), GO:0048484 (enteric nervous system development), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)