Protein: Methylcytosine dioxygenase TET (A0A8M9Q186)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development
Subcellular location: Chromosome
InterPro domains:
- IPR024779: 2OGFeDO JBP1/TET, oxygenase domain (domain) [1304-1722]
- IPR046942: Methylcytosine dioxygenase TET1-3, oxygenase domain (domain) [1304-1722]
- IPR002857: Zinc finger, CXXC-type (domain) [402-443]
- IPR040175: Methylcytosine dioxygenase TET1/2/3 (family) [4-1618]
Sequence:
MPRTAKAPKKSTRASTKRNVKRVKASITRRQTINSLKASGEIKKGIDKKQAAKRAQRTVVSKPNKKTVEDVLPVKISRHTTSSLNQNGLLLECNGKGKSPRKSVSCPSIQRNVQKKGAQEIREQETETKRSEVNDPNDDAEQQKGAEIPTGEGQSVNISSKESGEEHRETVVNDTLVAEKKKVKVNTETVQSESYSAVVEQPNTVLVDQQDPLKHNPVNNVDFAYNNNTSGPPTPSPSDQVEAIQPTLPPVDLQDISLQTTRGNSTEEGETAESSLPNQVCQSSNDSPALENIADAPQIEETELRSTADVDTKDESIDAEMLMKKEGALSLLSLSAAIYNTTLCEMGHGPQATALLSSSTESTQSSFDSESELVLEHRTSGKSIPQVEDIQLRLLQDQQRREQNKRGHCGVCAPCQCKVNCGECRSCLNQKTDHQICRLRKCIKLRKKTLIICTGKVESEANSVNGTSSEQMEETCAAPEEEAHYIPVTHNVPPDIITPLQHGLLPEPHGKDPGTTDVLLPHSFSSTSHNGAEHIKSNAQRYVDPTETPANFHSSTINNRHAPEVVQEQMVPLKKIKLEEQQLEIDDQHSKHLETNGCYEDALSTLAAVVCFSSTDRKSLEEKLFGSQTSDVCLKTEPKEEPYQCQLNQEEPPQNDYIALSLPTVQSLVQHRNISVDQAIAIEALTQLAAIPQTVPFKTENQIQDAQQETSTYSAPSNHIPIREAKPATDVVSNKVSVISSSLHQTSVIRSSLNTPTNFTQSQRCAPPPRKLSLKDLLMASSECEKLSYTTENRRNGQALCKSDRLEGTFKMYRHGEATPIYRKKDEEEVAAQLVQLAFMIESRQAQVSENSPPNGMATQSLKYNQNYLGQHLKKQRKPKMTPSNPRMSKKKVAEIDDNHCRILLAKKTPNKKTPLKATIQKAISQHKMRFQHKRNPFLPQAQIDLKKYIAEAQHENRQLLYYNTKKEHLETFIGSGRQNGFHVKYEHGGHSLPPQNGHFYNHTNDHLGASQCPRHECEQKVSQVSKTYDVLNPGAKQQLLQTMANEPFKDLPQIPEMYHKANGFNGHQHLHTNQNGFYKVEKSGGVTVLSASSVHSENGDMVYAGEQTPTKHTINSFLESPMRFLDTPTRNLINTPSKQSMEIPSCDCVEHIIEKEEGPYYTHLGSGPNVAAVREMMETRYGEKGNAVRVEVVVYTGKEGRSSQGCPIAKWIIRRGSEQEKLLCLVRQRAGHCCQNAVIVILILAWEGIPRSVADRLYQELTQTLCKYGSPTSRRCALNEDRTCACQGLDPETCGASFSFGCSWSMYFNGCKFARSKTPRKFRLQGDSPKEEGRLEKNLQNLASDLAPVYKRLAPKAFHNQVEQEQRGQDCRLGCREGRPFSGVTACVDFCAHAHKDTHNMTNGSTVVCTLTKEDNRAVRNIPEDEQLHVLPLYKISDTDEFGKVEGQWAKIKTGALQVLSAFPREVRLLAEPVKSAHKRRLEAKRAHVEKLNSLGSKQVTPVKMKNESPKGFKQTSTENSSFSEKNSPNLSSTMRVPDIGGQYSPLHSGGSYNQSNSCRTPPVGSSFGTSTLPKFPHDPSGGTTHFNGSPPFRHGTIKQEPFRNDPVRTNPKFKSEPEEMRCFQGGAAPTPLSPPMAEGLHSRLNITAQPVTPEVAKAEEVWSDSEHNFLDKNIGGVAVAPSHGSILIECARRELHATTPILRPDRTHPTRISLVFYQHKSLNAPGHGLQQWEAKRAEKAREKEQAERLGLNNQSEPVDSDTDSENETCLDERHKFQVPTRQSLTVSRDSLVMSAPYALTHVTGPYNRWT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:1990404 (NAD+-protein ADP-ribosyltransferase activity), GO:0016757 (glycosyltransferase activity), GO:0016763 (pentosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0051716 (cellular response to stimulus), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0001666 (response to hypoxia), GO:0043207 (response to external biotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0070482 (response to oxygen levels), GO:0009617 (response to bacterium), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0001817 (regulation of cytokine production), GO:0071216 (cellular response to biotic stimulus), GO:0010033 (response to organic substance), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032656 (regulation of interleukin-13 production), GO:0032496 (response to lipopolysaccharide), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0036293 (response to decreased oxygen levels), GO:0002237 (response to molecule of bacterial origin), GO:1901701 (cellular response to oxygen-containing compound), GO:0010468 (regulation of gene expression), GO:0071222 (cellular response to lipopolysaccharide), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)