Protein: Integrin beta (A6JK86)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR012896: Integrin beta subunit, tail (domain) [543-621]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [254-374]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [44-291]
- IPR057243: Integrins beta, I-EGF domain, conserved site (conserved_site) [512-525]
- IPR015439: Integrin beta-2 superfamily (homologous_superfamily) [5-45]
- IPR014836: Integrin beta subunit, cytoplasmic domain (domain) [645-690]
- IPR002369: Integrin beta subunit, VWA domain (domain) [1-369]
- IPR057073: Integrin beta, epidermal growth factor-like domain 2 (domain) [414-457]
- IPR015812: Integrin beta subunit (family) [14-688]
- IPR036349: Integrin beta tail domain superfamily (homologous_superfamily) [543-619]
Sequence:
MDPKSFADLHPQYQVQRSQLSPQKVTLNLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLNNVKKLGGDLLQALNEITESGRIGFGSFVDKTVLPFVNTHPEKLRNPCPNKEKACQPPFAFRHVLKLTDNSNQFQTEVGKQLISGNLDAPEGGLDAIMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNMYKRSNEFDYPSVGQLAHKLSESNIQPIFAVTKKMVKTYEKLTEIIPKSAVGELSDDSSNVVQLIKKAYYKLSSRVFLDHTTIPDTLKVTYDSFCNNRVSSIGKSRGDCDGVQINNPVTFQVKVTASECIQEQSFVIRALGFTDTVTVQVHPQCECQCRDQSRMRNLCGGKGVMECGICRCESGYIGKNCECQTQGRSSQELEGNCRKDNSSIVCSGLGDCICGQCVCHTSDIPNKVIFGQYCECDNFNCERYDGQVCGGLKRGSCSCGQCNCKEGFEGSACQCQRSTTGCLNARLVECSGRGRCQCNRCICEKGYQPPLCEECPGCPLPCSTYVFCAECLKFDKGPFQKNCSVQCANVTLQTVPFKKKPCKERDSEGCWITYTLQQKDGNAYNIHVDDDRECVKGPNVAAIIGGTVAGVVLIGVLLLVIWKALTHLTDLNEYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0001775 (cell activation), GO:0048870 (cell motility), GO:0090130 (tissue migration), GO:0048522 (positive regulation of cellular process), GO:0050900 (leukocyte migration), GO:0019222 (regulation of metabolic process), GO:0045321 (leukocyte activation), GO:0007155 (cell adhesion), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0007568 (aging), GO:0051094 (positive regulation of developmental process), GO:1904018 (positive regulation of vasculature development), GO:2000026 (regulation of multicellular organismal development), GO:0044093 (positive regulation of molecular function), GO:0002523 (leukocyte migration involved in inflammatory response), GO:0098609 (cell-cell adhesion), GO:0031325 (positive regulation of cellular metabolic process), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0006952 (defense response), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0090132 (epithelium migration), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0045123 (cellular extravasation), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0046649 (lymphocyte activation), GO:0016477 (cell migration), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010631 (epithelial cell migration), GO:1904407 (positive regulation of nitric oxide metabolic process), GO:0006954 (inflammatory response), GO:0080164 (regulation of nitric oxide metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0030101 (natural killer cell activation), GO:0031326 (regulation of cellular biosynthetic process), GO:1901342 (regulation of vasculature development), GO:0045766 (positive regulation of angiogenesis), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0045765 (regulation of angiogenesis), GO:0051252 (regulation of RNA metabolic process), GO:0007159 (leukocyte cell-cell adhesion), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:0001667 (ameboidal-type cell migration), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0045429 (positive regulation of nitric oxide biosynthetic process), GO:0045428 (regulation of nitric oxide biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0043542 (endothelial cell migration), GO:0051092 (positive regulation of NF-kappaB transcription factor activity), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009986 (cell surface), GO:0005886 (plasma membrane)