Protein: E3 ubiquitin-protein ligase CBL (A6J3W2)
Organism: Rattus norvegicus (Rat)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome
InterPro domains:
- IPR024159: Adaptor protein Cbl, PTB domain (domain) [1-297]
- IPR011992: EF-hand domain pair (homologous_superfamily) [124-209]
- IPR015940: Ubiquitin-associated domain (domain) [794-833]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [325-334]
- IPR014742: Adaptor protein Cbl, SH2-like domain (domain) [202-298]
- IPR009060: UBA-like superfamily (homologous_superfamily) [780-831]
- IPR003153: Adaptor protein Cbl, N-terminal helical (domain) [1-121]
- IPR014741: Adaptor protein Cbl, EF hand-like (domain) [125-208]
- IPR018957: Zinc finger, C3HC4 RING-type (domain) [311-348]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [315-364]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [210-296]
- IPR036537: Adaptor protein Cbl, N-terminal domain superfamily (homologous_superfamily) [1-123]
- IPR024162: Adaptor protein Cbl (family) [2-484]
- IPR001841: Zinc finger, RING-type (domain) [310-349]
Sequence:
MVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTVLSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDSLFMMKELAGAKVERPSSPFSMAPQASLPPVPPRLDLLQQRAPVPASTSVLGTASKASSSSLHKDKPLPIPPTLRDLPPPPPPDRPYSVGTETRPQRRPLPCTPGDCPSRDKLPPVPSSRPGDSWLSRPIPKVPVATPNPGDPWNGRELTNRHSLPFSLPSQMEPRADVPRLGSTFSLDTSTTMNSSPVAGPESEHPKIKPSSSANAIYSLAARPLPVPKLPPGEQGDSEEDTEYMTPTSRPVGVQKPEPKRPAETAQSSRACDCDQQIDSCTYEAMYNIQSQALSVAENSACGEGNLATAHTSTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGEPTNFNEGSQVPERPPKPFPRRINSERKASSYQQGGGAMANPAAAAPSPQLSSEIERLMSQGYSYQDIQKALVIAHNNIEMAKNILREFVSISSPAHVAT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0043548 (phosphatidylinositol 3-kinase binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0019904 (protein domain specific binding), GO:0019899 (enzyme binding), GO:0004842 (ubiquitin-protein transferase activity), GO:0017124 (SH3 domain binding), GO:0019900 (kinase binding), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity), GO:0019901 (protein kinase binding), GO:1990782 (protein tyrosine kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0002376 (immune system process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0006955 (immune response), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0014823 (response to activity), GO:0003006 (developmental process involved in reproduction), GO:0051640 (organelle localization), GO:0009719 (response to endogenous stimulus), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0002252 (immune effector process), GO:0006950 (response to stress), GO:0140352 (export from cell), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0060548 (negative regulation of cell death), GO:0002366 (leukocyte activation involved in immune response), GO:0009314 (response to radiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0070482 (response to oxygen levels), GO:0048513 (animal organ development), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0051649 (establishment of localization in cell), GO:0048608 (reproductive structure development), GO:1901700 (response to oxygen-containing compound), GO:0045137 (development of primary sexual characteristics), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0043299 (leukocyte degranulation), GO:0070997 (neuron death), GO:0009991 (response to extracellular stimulus), GO:0042594 (response to starvation), GO:0010941 (regulation of cell death), GO:0051656 (establishment of organelle localization), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:1990849 (vacuolar localization), GO:0006810 (transport), GO:0046677 (response to antibiotic), GO:0002263 (cell activation involved in immune response), GO:0032940 (secretion by cell), GO:0002443 (leukocyte mediated immunity), GO:0031668 (cellular response to extracellular stimulus), GO:0007548 (sex differentiation), GO:0002274 (myeloid leukocyte activation), GO:0046661 (male sex differentiation), GO:0071496 (cellular response to external stimulus), GO:0036119 (response to platelet-derived growth factor), GO:0061458 (reproductive system development), GO:0097305 (response to alcohol), GO:1901215 (negative regulation of neuron death), GO:0043303 (mast cell degranulation), GO:0032418 (lysosome localization), GO:1901654 (response to ketone), GO:0071453 (cellular response to oxygen levels), GO:0006974 (cellular response to DNA damage stimulus), GO:1990089 (response to nerve growth factor), GO:0008406 (gonad development), GO:0046546 (development of primary male sexual characteristics), GO:1901214 (regulation of neuron death), GO:0046903 (secretion), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006887 (exocytosis), GO:0045576 (mast cell activation), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0036293 (response to decreased oxygen levels), GO:0002444 (myeloid leukocyte mediated immunity), GO:0016192 (vesicle-mediated transport), GO:0002275 (myeloid cell activation involved in immune response), GO:0014070 (response to organic cyclic compound), GO:0010212 (response to ionizing radiation), GO:0031669 (cellular response to nutrient levels), GO:0071363 (cellular response to growth factor stimulus), GO:0036120 (cellular response to platelet-derived growth factor stimulus), GO:0045471 (response to ethanol), GO:0090649 (response to oxygen-glucose deprivation), GO:0070647 (protein modification by small protein conjugation or removal), GO:0002279 (mast cell activation involved in immune response), GO:0010332 (response to gamma radiation), GO:0008584 (male gonad development), GO:0036294 (cellular response to decreased oxygen levels), GO:0002448 (mast cell mediated immunity), GO:1990090 (cellular response to nerve growth factor stimulus), GO:0045055 (regulated exocytosis), GO:0033574 (response to testosterone), GO:0090650 (cellular response to oxygen-glucose deprivation), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination), GO:0051865 (protein autoubiquitination), GO:0006513 (protein monoubiquitination), GO:0000209 (protein polyubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0030427 (site of polarized growth), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098857 (membrane microdomain), GO:0120025 (plasma membrane bounded cell projection), GO:0070161 (anchoring junction), GO:0030426 (growth cone), GO:0005886 (plasma membrane), GO:0030055 (cell-substrate junction), GO:0043005 (neuron projection), GO:0045121 (membrane raft), GO:0005925 (focal adhesion), GO:0030424 (axon)