Protein: Dual specificity mitogen-activated protein kinase kinase 1 (A0A8I5KYB4)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Nucleus
InterPro domains:
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [186-198]
- IPR000719: Protein kinase domain (domain) [68-355]
- IPR017441: Protein kinase, ATP binding site (binding_site) [74-97]
- IPR050915: MAP kinase kinase (family) [9-343]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [63-342]
Sequence:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKWFMLLSRDLMLRKWILQVGSAPPSALTSPAHQPMLLASKCLGSNKERVPCPVVCHVAFGPPSHACLCSDVHFTCDKG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0060090 (molecular adaptor activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0016740 (transferase activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0035591 (signaling adaptor activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0097110 (scaffold protein binding), GO:0019904 (protein domain specific binding), GO:0019207 (kinase regulator activity), GO:0008047 (enzyme activator activity), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0005078 (MAP-kinase scaffold activity), GO:0019209 (kinase activator activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004712 (protein serine/threonine/tyrosine kinase activity), GO:0030165 (PDZ domain binding), GO:0019887 (protein kinase regulator activity), GO:0030295 (protein kinase activator activity), GO:0004708 (MAP kinase kinase activity), GO:0043539 (protein serine/threonine kinase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0023056 (positive regulation of signaling), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0042330 (taxis), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0035556 (intracellular signal transduction), GO:0080134 (regulation of response to stress), GO:0060341 (regulation of cellular localization), GO:0008285 (negative regulation of cell population proliferation), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0060627 (regulation of vesicle-mediated transport), GO:0043170 (macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0006793 (phosphorus metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0033554 (cellular response to stress), GO:0009889 (regulation of biosynthetic process), GO:0090398 (cellular senescence), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0006935 (chemotaxis), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0032386 (regulation of intracellular transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0000165 (MAPK cascade), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:0010628 (positive regulation of gene expression), GO:0006796 (phosphate-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:0036211 (protein modification process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0043412 (macromolecule modification), GO:2000641 (regulation of early endosome to late endosome transport), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0033043 (regulation of organelle organization), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0051338 (regulation of transferase activity), GO:0043085 (positive regulation of catalytic activity), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0051174 (regulation of phosphorus metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006468 (protein phosphorylation), GO:0006355 (regulation of DNA-templated transcription), GO:0019220 (regulation of phosphate metabolic process), GO:0016310 (phosphorylation), GO:1903649 (regulation of cytoplasmic transport), GO:0070371 (ERK1 and ERK2 cascade), GO:0043549 (regulation of kinase activity), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0043410 (positive regulation of MAPK cascade), GO:1903358 (regulation of Golgi organization), GO:0031401 (positive regulation of protein modification process), GO:0032872 (regulation of stress-activated MAPK cascade), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0045893 (positive regulation of DNA-templated transcription), GO:0033674 (positive regulation of kinase activity), GO:0045859 (regulation of protein kinase activity), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0001934 (positive regulation of protein phosphorylation), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0045860 (positive regulation of protein kinase activity), GO:0071902 (positive regulation of protein serine/threonine kinase activity), GO:0043405 (regulation of MAP kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)