Protein: Protein UL138 (F5HGQ8)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Plays an important role in the establishment of latent viral infection. Modulates the expression of several host cell surface receptors such as TNFR1, CD36 or the MRP1 transporter during productive infection. For instance, associates with host MRP1 and induces its lysosomal degradation. Plays an inhibitory role in the host cGAS/STING/TBK1 pathway and upstream of IRF3 phosphorylation and NF-kappa-B leading to inhibition of interferon beta production during both lytic and latent infections. Participates also in the establishment of latency by sustaining an innate immune response through phosphorylation and activation of host STAT1
Subcellular location: Host Golgi apparatus membrane
InterPro domains:
Sequence:
MDDLPLNVGLPIIGVMLVLIVAILCYLAYHWHDTFKLVRMFLSYRWLIRCCELYGEYERRFADLSSLGLGAVRRESDRRYRFSERPDEILVRWEEVSSQCSYASSRITDRRAGSSSSSSVHVANQRNSVPPPDMAVTAPLTDVDLLKPVTGSATQFTTVAMVHYHQEYT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048519 (negative regulation of biological process), GO:0016032 (viral process), GO:0009605 (response to external stimulus), GO:0044068 (modulation by symbiont of host cellular process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0002682 (regulation of immune system process), GO:0035821 (modulation of process of another organism), GO:0019048 (modulation by virus of host process), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0048585 (negative regulation of response to stimulus), GO:0052027 (modulation by symbiont of host signal transduction pathway), GO:0044501 (modulation of signal transduction in another organism), GO:0051701 (biological process involved in interaction with host), GO:0075528 (modulation by virus of host immune response), GO:0050776 (regulation of immune response), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0080134 (regulation of response to stress), GO:0044003 (modulation by symbiont of host process), GO:0075136 (response to host), GO:0039503 (suppression by virus of host innate immune response), GO:0019054 (modulation by virus of host cellular process), GO:0031348 (negative regulation of defense response), GO:0044414 (suppression of host defenses by symbiont), GO:0031347 (regulation of defense response), GO:0052200 (response to host defenses), GO:0075109 (modulation by symbiont of host receptor-mediated signal transduction), GO:0052029 (suppression by symbiont of host signal transduction pathway), GO:0052031 (modulation by symbiont of host defense response), GO:0039537 (suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway), GO:0019049 (mitigation of host antiviral defense response), GO:0052170 (suppression by symbiont of host innate immune response), GO:0075111 (suppression by symbiont of host receptor-mediated signal transduction), GO:0052572 (response to host immune response), GO:0030682 (mitigation of host defenses by symbiont), GO:0052553 (modulation by symbiont of host immune response), GO:0052167 (modulation by symbiont of host innate immune response), GO:0052562 (suppression by symbiont of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0044423 (virion component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0019033 (viral tegument), GO:0043657 (host cell), GO:0033643 (host cell part), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0039713 (viral factory), GO:0030430 (host cell cytoplasm), GO:0033655 (host cell cytoplasm part), GO:0039714 (cytoplasmic viral factory), GO:0033647 (host intracellular organelle), GO:0033648 (host intracellular membrane-bounded organelle)