lokahq/bioreason-rl huggingface dataset:
Protein: Glycogen [starch] synthase (Q5A850)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan
InterPro domains:
- IPR008631: Glycogen synthase (family) [3-650]
Sequence:
MARDIDNHLLFEVATEVAHKVGGIYSVLKSKAPVTVAEYRERYTLLGPLHYDSAQIEVEELPVTDPHIKQTLDSMSSKGIRWLYGRWLIEGAPRVLLFDIWSAGHYLNEWKADLWNVAGIPTPDHDSETNDAILLGYLVAWFLGELVYNDRDRAVICQCHEWLAGIALPLCRKRRIDVTTIFTTHATLLGRYLCAGSTDFYNNLDKFDVDAEAGKRGIYHRYCIERSATHSADVFTTVSDITAYEAEHLLKRKPDGVLPNGLNVVKFQAVHEFQNLHAIKKAKINEFVKGHFYGNYDFDLDNTLYFFIAGRYEFRNKGCDFFIESLARLNHKLKEAGSKTTVVAFIIMPGKTQSYTVETLKGQAVVKQLESTIGEVQKKVGERLFEYCARYPNTDHHGNDEVPTIDELIKPADRVLLKRRIFALKRDGLPPIVTHNMVDDSTDPVLNHIRRVQLFNKPEDRVKIIFHPEFLNANNPILSLDYDEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSITTNLSGFGCYMNDLVENPTDYGIYIVDRRMKSVDESINQLTDYMFDFCAKSRRQRINQRNRTERLSVLLDWRSVHSEYSKARLLALKRAYPDYVGEKVVESKMKITRPMSVPGSPRSLLLTPGDLGSLQDANQDISYFELGEEET
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0046527 (glucosyltransferase activity), GO:0035251 (UDP-glucosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044249 (cellular biosynthetic process), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0009059 (macromolecule biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0044264 (cellular polysaccharide metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0005976 (polysaccharide metabolic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:0006112 (energy reserve metabolic process), GO:0000271 (polysaccharide biosynthetic process), GO:0033692 (cellular polysaccharide biosynthetic process), GO:0044042 (glucan metabolic process), GO:0006073 (cellular glucan metabolic process), GO:0009250 (glucan biosynthetic process), GO:0005977 (glycogen metabolic process), GO:0005978 (glycogen biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Divalent metal ion transporter (A0A1D8PFT1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
InterPro domains:
- IPR001046: NRAMP family (family) [1-646]
Sequence:
MRFIGPGLMVSVAYMDPGNYSTAVAAGSAYKYNLLFSILLSNCLAIFLQILAAKLGAVTGLDLAANCKAHFGYKTNLILYALTEIAIIATDLAEVVGTAIALNILFHLPLFVGVIVTVIDVLIVLMAYRPRGPLLFIRIFESFVSVLVAATVVCFGIELYQVSHDSSIHFSVAEVMKGFLPNEDVVDMSDREGGNGLFLSLAILGATVMPHSLYLGSGLVQARLKDYDIKNGFHKPWGKHSIEEPIQEDITVHEEDDNLTPIATPLIQHQEQPGFEKDDESTFDGDDEEDDHYRPSIHAIKDTMSYTIVELVISLFTVALFVNAAILIVAGATLRSGDSKFARDDDNGHESDSDSDDDYQNADLFTIYHLLSKHLSPTAGFVFALALLCSGQSAGVVCTLAGQMVSEGFLSWSLPPVTRRLITRALAIAPCLLVVSFSGREGLAKILNASQVVLSILLPVVSAPLIWFTCNKHTMRVPIFVRDGDEEIDMEYDGEQSTSVATSRFKSSEPAIRLQNLRNSHPCANWEDDDDEQLQQLHLQNEENRLLIGENTTNLVYSSPPTSNLMSRSNSVSATNGVPDSSSSSSSTTIAAQLPLEVYEDLNQDIFRIKGYKDFSNSLATSFVAVLVWVFVASLNLYLIGSMLLGYDVPL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0005381 (iron ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006810 (transport), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055070 (copper ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0006878 (intracellular copper ion homeostasis), GO:0006812 (monoatomic cation transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0015691 (cadmium ion transport), GO:0006826 (iron ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: NADPH:quinone reductase (Q59Z38)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
InterPro domains:
- IPR013149: Alcohol dehydrogenase-like, C-terminal (domain) [211-325]
- IPR011032: GroES-like superfamily (homologous_superfamily) [57-204]
- IPR002364: Quinone oxidoreductase/zeta-crystallin, conserved site (conserved_site) [200-221]
- IPR020843: Enoylreductase domain (domain) [67-381]
- IPR013154: Alcohol dehydrogenase-like, N-terminal (domain) [85-142]
- IPR047618: Quinone oxidoreductase-like (family) [59-383]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [177-334]
Sequence:
MQLINQFSKSPPLLQFNSPNFKFIFKYSLLLFFLIIVIFLFLYPPSIYQIMSILPETQKVVLHRENGDYDVIEYSDFPTPKIESSHDIIVKNSYAGVNFIEAYFRKGIYKASLPYVFGREASGEVVAVGDEVSTLKVGDKIAYLSPNTFAQYTKITDDNYKYIKLPDNASDEELKIYGSLFLQGLTALTFVNEAYKVQKDDYILVWAAAGGVGKILVQLISQLGAHVIAVASTPEKLKIAQDLGAEFLINSTSDDIVEKVKEITNGEGVAASFDSVGKDTFEISLNSIKRKGTFVSYGNASGPVTPFPLSILSPKNIKIARPQLYAYIGNADEWDHYSTELLKLFESGKLKFDIFKTYDLKDYVQAAKDLEGRKTTGKLTLKIS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006979 (response to oxidative stress), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0034599 (cellular response to oxidative stress), GO:0062197 (cellular response to chemical stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: Peptidase A1 domain-containing protein (A0A2H0ZXQ6)
Organism: Candida auris (Yeast)
InterPro domains:
- IPR001969: Aspartic peptidase, active site (active_site) [91-102]
- IPR033121: Peptidase family A1 domain (domain) [75-381]
- IPR001461: Aspartic peptidase A1 (family) [45-380]
- IPR033876: Secreted aspartic endopeptidase (domain) [74-381]
- IPR021109: Aspartic peptidase domain superfamily (homologous_superfamily) [29-390]
Sequence:
MSLVSGLVLPQNDDASVAKRGAQPLKLDFDIVKDTSKNSTLYHPQRYFENLRAARGANHAKRSTSTTITNDRDISYILDVYLGSQHDKVTVLLDTGSSDLWVYGPGVSSAEGGTFDPSQSSHDQSTGESFSIQYLDNSGAEGSYYLDDFSFNSGSTLVSNFQFAVVSSANADSTGILGVADKGQEAVEGEPTYDNLPWALQKSGVTPKASYSLFLGSEQEGKGSIIFGGIDTDKYEGDLKKYQVSTDQGLGITAQSATVGGKSISLGQSYILDSGTSWNLWPTDLTEAVAQELGLISYQQGLYIVNCDQPSDKSISFDLGENSISIPYSDLIVNVGENGQKVCSLGAQATDYDPYIFGDVFLRSAYVYYDLTDHTISIAQAKYSTSSHIVPA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity), GO:0070001 (aspartic-type peptidase activity), GO:0004190 (aspartic-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: LysM domain-containing protein (F9XMT4)
Organism: Zymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch
InterPro domains:
- IPR018392: LysM domain (domain) [47-222]
- IPR036779: LysM domain superfamily (homologous_superfamily) [41-222]
Sequence:
MQNIFLAATLLGAAFAAPQNPPTSCSAAPQPTGTGSPGTVCGSTTFTNYTVKAGDTLGAIAKQYNSGVCDIAKVNGIDNPDYIKPDQVLSIPANCVTPDNTSCVKPVPVITNTCVLGVGSTYTVKSGDSFSAIATSFNITLASLEARNPQIPNYDLIFPGQVINTPLCPNSVCDSIGTYVIESGDIFYNLAQSNNVTVGQLESLNVNVNVTDIHPGDIIILPHNCHNITASA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140313 (molecular sequestering activity), GO:0097367 (carbohydrate derivative binding), GO:0008061 (chitin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0048583 (regulation of response to stimulus), GO:0035821 (modulation of process of another organism), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0048585 (negative regulation of response to stimulus), GO:0051701 (biological process involved in interaction with host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0080134 (regulation of response to stress), GO:0044003 (modulation by symbiont of host process), GO:0075136 (response to host), GO:0031348 (negative regulation of defense response), GO:0044414 (suppression of host defenses by symbiont), GO:0031347 (regulation of defense response), GO:0052200 (response to host defenses), GO:0140418 (effector-mediated modulation of host process by symbiont), GO:0052031 (modulation by symbiont of host defense response), GO:0052170 (suppression by symbiont of host innate immune response), GO:0140415 (effector-mediated modulation of host defenses by symbiont), GO:0052572 (response to host immune response), GO:0030682 (mitigation of host defenses by symbiont), GO:0140404 (effector-mediated modulation of host innate immune response by symbiont), GO:0052553 (modulation by symbiont of host immune response), GO:0052167 (modulation by symbiont of host innate immune response), GO:0052562 (suppression by symbiont of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: LysM domain-containing protein (F9XHX3)
Organism: Zymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch
InterPro domains:
- IPR018392: LysM domain (domain) [37-85]
- IPR036779: LysM domain superfamily (homologous_superfamily) [31-97]
Sequence:
MQFTALVAALLSVAAVQAQRNPITITPQFDCGATNSQQYVARSGDTLTKIAQEIYHDVVGVCDIARANNLADPNRIDAGTPYTIPINCQTYDRNSCL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097367 (carbohydrate derivative binding), GO:0008061 (chitin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0035821 (modulation of process of another organism), GO:0051701 (biological process involved in interaction with host), GO:0044003 (modulation by symbiont of host process), GO:0140418 (effector-mediated modulation of host process by symbiont)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Thioredoxin reductase (A0A0W0DN46)
Organism: Candida glabrata (Yeast) (Torulopsis glabrata)
InterPro domains:
- IPR023753: FAD/NAD(P)-binding domain (domain) [7-307]
- IPR008255: Pyridine nucleotide-disulphide oxidoreductase, class-II, active site (active_site) [145-167]
- IPR050097: Ferredoxin--NADP reductase type 2 (family) [7-320]
- IPR005982: Thioredoxin reductase (family) [8-318]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [4-318]
Sequence:
MTNMNHKKVVIIGSGPAAHTAAIYLARAEIKPTMYEGMLANGIAAGGQLTTTTEIENFPGFPDGMTGSELMDRMRAQSTKFGTEIITETIAKVDLSSRPFKLWTEFNEDGEPITTDAIVIATGASAKRLHIPGEETYWQQGISACAVCDGAVPIFRNKPLAVIGGGDSACEEAQFLTKYGSKVYLIVRKDHLRASTIMQRRAEQNDKIEILYNTVTLEAQGDGKLLNNLRIKNVKTNEETDLPVNGLFYAIGHTPATKIVEGQVETDETGYIKTIPGSSLTSVPGVFAAGDVQDSKYRQAITSAGSGCMAGLDAEKYLTELE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016209 (antioxidant activity), GO:0004791 (thioredoxin-disulfide reductase activity), GO:0043167 (ion binding), GO:0140096 (catalytic activity, acting on a protein), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0043169 (cation binding), GO:0015035 (protein-disulfide reductase activity), GO:0047134 (protein-disulfide reductase (NAD(P)) activity), GO:0016668 (oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor), GO:0015036 (disulfide oxidoreductase activity), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005506 (iron ion binding), GO:0008198 (ferrous iron binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006979 (response to oxidative stress), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0034599 (cellular response to oxidative stress), GO:0062197 (cellular response to chemical stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: Neuropeptide FF receptor 2 (A0A804CC06)
Organism: Homo sapiens (Human)
Function: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [1-217]
- IPR005395: Neuropeptide FF receptor family (family) [28-232]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [1-225]
- IPR005397: Neuropeptide FF receptor, type 2 (family) [65-303]
Sequence:
MCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0051606 (detection of stimulus), GO:0050794 (regulation of cellular process), GO:0009582 (detection of abiotic stimulus), GO:0007186 (G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)
Protein: Chloride channel CLIC-like protein 1 (A0A6Q8PFF7)
Organism: Homo sapiens (Human)
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR009231: Chloride channel CLIC-like (family) [1-431]
Sequence:
MHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILINFKFHDFETWKWRFEDSFGVDPYNVLMVLLCLLCIVVLVATELWTYVRWYTQLRRVLIISFLFSLGWNWMYLYKLAFAQHQAEVAKMEPLNNVCAKKMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTTFVTEPLKHIGKGTGEFIKALMKEIPALLHLPVLIIMALAILSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSQSAKPVSGQDTSGNTEGSPAAEKAQLKSEAAGSPDQGSTYSPARGVAGPRGQDPVSSPCG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0044085 (cellular component biogenesis), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0051668 (localization within membrane), GO:0045184 (establishment of protein localization), GO:0006839 (mitochondrial transport), GO:0090151 (establishment of protein localization to mitochondrial membrane), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0071702 (organic substance transport), GO:0043933 (protein-containing complex organization), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0090150 (establishment of protein localization to membrane), GO:0061024 (membrane organization), GO:0072657 (protein localization to membrane), GO:0022607 (cellular component assembly), GO:0072655 (establishment of protein localization to mitochondrion), GO:0007005 (mitochondrion organization), GO:0033365 (protein localization to organelle), GO:0007006 (mitochondrial membrane organization), GO:0006605 (protein targeting), GO:0051205 (protein insertion into membrane), GO:0065003 (protein-containing complex assembly), GO:0051204 (protein insertion into mitochondrial membrane), GO:0006626 (protein targeting to mitochondrion), GO:0070585 (protein localization to mitochondrion), GO:0045040 (protein insertion into mitochondrial outer membrane), GO:0051131 (chaperone-mediated protein complex assembly), GO:0007008 (outer mitochondrial membrane organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Pro-cathepsin H (A0A7I2YQX6)
Organism: Homo sapiens (Human)
Function: Important for the overall degradation of proteins in lysosomes
Subcellular location: Lysosome
InterPro domains:
- IPR025661: Cysteine peptidase, asparagine active site (active_site) [220-239]
- IPR013128: Peptidase C1A (family) [3-250]
- IPR000169: Cysteine peptidase, cysteine active site (active_site) [59-70]
- IPR039417: Papain-like cysteine endopeptidase (domain) [41-255]
- IPR025660: Cysteine peptidase, histidine active site (active_site) [203-213]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [1-257]
- IPR000668: Peptidase C1A, papain C-terminal (domain) [40-256]
Sequence:
MALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle)