Protein: Cytotoxic T-lymphocyte protein 4 (Q9Z1A7)
Organism: Rattus norvegicus (Rat)
Function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28
Subcellular location: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR013106: Immunoglobulin V-set domain (domain) [41-151]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [36-161]
- IPR040216: Cytotoxic T-lymphocyte protein 4/CD28 (family) [25-158]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [38-154]
- IPR007110: Immunoglobulin-like domain (domain) [32-132]
- IPR008096: Cytotoxic T-lymphocyte antigen 4 (family) [17-122]
- IPR003599: Immunoglobulin domain subtype (domain) [43-152]
Sequence:
MACLGLQRYKTHLQLPSRTWPFGVLLSLLFIPIFSEAIQVTQPSVVLASSHGVASFPCEYASSHNTDEVRVTVLRQTNDQVTEVCATTFTVKNTLGFLDDPFCSGTFNESRVNLTIQGLRAADTGLYFCKVELMYPPPYFVGMGNGTQIYVIAKEKKSSYNRGLCENAPNRARM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0002683 (negative regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050777 (negative regulation of immune response), GO:0002695 (negative regulation of leukocyte activation), GO:0050776 (regulation of immune response), GO:0050866 (negative regulation of cell activation), GO:0042127 (regulation of cell population proliferation), GO:0007162 (negative regulation of cell adhesion), GO:0008285 (negative regulation of cell population proliferation), GO:0030155 (regulation of cell adhesion), GO:0002694 (regulation of leukocyte activation), GO:0050865 (regulation of cell activation), GO:0022407 (regulation of cell-cell adhesion), GO:0070664 (negative regulation of leukocyte proliferation), GO:0022408 (negative regulation of cell-cell adhesion), GO:0070663 (regulation of leukocyte proliferation), GO:0051250 (negative regulation of lymphocyte activation), GO:0051249 (regulation of lymphocyte activation), GO:0050670 (regulation of lymphocyte proliferation), GO:0050863 (regulation of T cell activation), GO:0032944 (regulation of mononuclear cell proliferation), GO:0050672 (negative regulation of lymphocyte proliferation), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903038 (negative regulation of leukocyte cell-cell adhesion), GO:0050868 (negative regulation of T cell activation), GO:0032945 (negative regulation of mononuclear cell proliferation), GO:0042130 (negative regulation of T cell proliferation), GO:0042129 (regulation of T cell proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0009986 (cell surface), GO:0005615 (extracellular space)