Protein: DNA helicase (A0A7P0TBM9)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR010997: HRDC-like superfamily (homologous_superfamily) [1217-1287]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [1073-1188]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [664-865]
- IPR001650: Helicase, C-terminal domain-like (domain) [877-1024]
- IPR004589: DNA helicase, ATP-dependent, RecQ type (family) [657-1143]
- IPR032437: RecQ-like DNA helicase BLM, N-terminal domain (domain) [1-368]
- IPR032284: ATP-dependent DNA helicase RecQ, zinc-binding domain (domain) [995-1067]
- IPR044876: HRDC domain superfamily (homologous_superfamily) [1207-1298]
- IPR002121: HRDC domain (domain) [1212-1292]
- IPR032439: RecQ-like DNA helicase BLM, BDHCT-box associated domain (domain) [425-647]
- IPR012532: BDHCT (domain) [372-412]
- IPR011545: DEAD/DEAH-box helicase domain (domain) [670-839]
- IPR002464: DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site (conserved_site) [790-799]
- IPR018982: RQC domain (domain) [1072-1195]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [1073-1194]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [634-1094]
Sequence:
MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPLPNTTNQQRVKDFFKNAPAGQETQRGGSKSLLPDFLQTPKEVVCTTQNTPTVKKSRDTALKKLEFSSSPDSLSTINDWDDMDDFDTSETSKSFVTPPQSHFVRVSTAQKSKKGKRNFFKAQLYTTNTVKTDLPPPSSESEQIDLTEEQKDDSEWLSSDVICIDDGPIAEVHINEDAQESDSLKTHLEDERDNSEKKKNLEEAELHSTEKVPCIEFDDDDYDTDFVPPSPEEIISASSSSSKCLSTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQELNPETSTDCDARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLTEVDFNKSDASLLGSLWRYRPDSLDGPMEGDSCPTGNSMKELNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASINDLERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSESIQNYTDKSAQNLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKDYKTRDVTDDVKSIVRFVQEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLGSKSAKIQSGIFGKGSAYSRHNAERLFKKLILDKILDEDLYINANDQAIAYVMLGNKAQTVLNGNLKVDFMETENSSSVKKQKALVAKVSQREEMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPAEDSSPGISLSSSRGPGRSAAEELDEEIPVSSHYFASKTRNERKRKKMPASQRSKRRKTASSGSKAKGWSFPMLPRLVSNS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0140657 (ATP-dependent activity), GO:0036094 (small molecule binding), GO:0004386 (helicase activity), GO:0008094 (ATP-dependent activity, acting on DNA), GO:0097159 (organic cyclic compound binding), GO:0140677 (molecular function activator activity), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:1901265 (nucleoside phosphate binding), GO:0002039 (p53 binding), GO:0042802 (identical protein binding), GO:0043168 (anion binding), GO:0043169 (cation binding), GO:0003676 (nucleic acid binding), GO:0003678 (DNA helicase activity), GO:0046983 (protein dimerization activity), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0140097 (catalytic activity, acting on DNA), GO:0140666 (annealing activity), GO:0017076 (purine nucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0046872 (metal ion binding), GO:0043138 (3'-5' DNA helicase activity), GO:0042803 (protein homodimerization activity), GO:0003677 (DNA binding), GO:0032555 (purine ribonucleotide binding), GO:0005524 (ATP binding), GO:0003684 (damaged DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000217 (DNA secondary structure binding), GO:0032559 (adenyl ribonucleotide binding), GO:1990814 (DNA/DNA annealing activity), GO:0046914 (transition metal ion binding), GO:0030554 (adenyl nucleotide binding), GO:0003697 (single-stranded DNA binding), GO:0042162 (telomeric DNA binding), GO:0000400 (four-way junction DNA binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0048519 (negative regulation of biological process), GO:0042221 (response to chemical), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0009892 (negative regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0009628 (response to abiotic stimulus), GO:0019222 (regulation of metabolic process), GO:0007049 (cell cycle), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0051302 (regulation of cell division), GO:0044085 (cellular component biogenesis), GO:0009314 (response to radiation), GO:0044786 (cell cycle DNA replication), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0010948 (negative regulation of cell cycle process), GO:0051726 (regulation of cell cycle), GO:0010035 (response to inorganic substance), GO:1901360 (organic cyclic compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0071214 (cellular response to abiotic stimulus), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0045786 (negative regulation of cell cycle), GO:0044260 (cellular macromolecule metabolic process), GO:0010564 (regulation of cell cycle process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1903047 (mitotic cell cycle process), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0034641 (cellular nitrogen compound metabolic process), GO:0051782 (negative regulation of cell division), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0104004 (cellular response to environmental stimulus), GO:0006139 (nucleobase-containing compound metabolic process), GO:1901698 (response to nitrogen compound), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0000278 (mitotic cell cycle), GO:0097305 (response to alcohol), GO:0007346 (regulation of mitotic cell cycle), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0033260 (nuclear DNA replication), GO:0007093 (mitotic cell cycle checkpoint signaling), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0051053 (negative regulation of DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0045930 (negative regulation of mitotic cell cycle), GO:0006259 (DNA metabolic process), GO:0043933 (protein-containing complex organization), GO:0051252 (regulation of RNA metabolic process), GO:0010212 (response to ionizing radiation), GO:1901701 (cellular response to oxygen-containing compound), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0071478 (cellular response to radiation), GO:0071417 (cellular response to organonitrogen compound), GO:0000075 (cell cycle checkpoint signaling), GO:0051052 (regulation of DNA metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0071310 (cellular response to organic substance), GO:0042770 (signal transduction in response to DNA damage), GO:1901699 (cellular response to nitrogen compound), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010243 (response to organonitrogen compound), GO:1904029 (regulation of cyclin-dependent protein kinase activity), GO:0071241 (cellular response to inorganic substance), GO:1901987 (regulation of cell cycle phase transition), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0014070 (response to organic cyclic compound), GO:0051338 (regulation of transferase activity), GO:0006996 (organelle organization), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0051174 (regulation of phosphorus metabolic process), GO:1901988 (negative regulation of cell cycle phase transition), GO:1902750 (negative regulation of cell cycle G2/M phase transition), GO:0000018 (regulation of DNA recombination), GO:0065003 (protein-containing complex assembly), GO:2001141 (regulation of RNA biosynthetic process), GO:0006310 (DNA recombination), GO:0006281 (DNA repair), GO:0044818 (mitotic G2/M transition checkpoint), GO:0045910 (negative regulation of DNA recombination), GO:0044774 (mitotic DNA integrity checkpoint signaling), GO:0006260 (DNA replication), GO:0043549 (regulation of kinase activity), GO:1902749 (regulation of cell cycle G2/M phase transition), GO:0006275 (regulation of DNA replication), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0097306 (cellular response to alcohol), GO:0000077 (DNA damage checkpoint signaling), GO:0031570 (DNA integrity checkpoint signaling), GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity), GO:0043279 (response to alkaloid), GO:0031399 (regulation of protein modification process), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:0071479 (cellular response to ionizing radiation), GO:0000729 (DNA double-strand break processing), GO:0000723 (telomere maintenance), GO:0006355 (regulation of DNA-templated transcription), GO:0051276 (chromosome organization), GO:0071407 (cellular response to organic cyclic compound), GO:0019220 (regulation of phosphate metabolic process), GO:0045005 (DNA-templated DNA replication maintenance of fidelity), GO:0071312 (cellular response to alkaloid), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0010165 (response to X-ray), GO:0006261 (DNA-templated DNA replication), GO:0001932 (regulation of protein phosphorylation), GO:0010389 (regulation of G2/M transition of mitotic cell cycle), GO:0000725 (recombinational repair), GO:0007095 (mitotic G2 DNA damage checkpoint signaling), GO:0010972 (negative regulation of G2/M transition of mitotic cell cycle), GO:0045859 (regulation of protein kinase activity), GO:0090329 (regulation of DNA-templated DNA replication), GO:0032200 (telomere organization), GO:0051259 (protein complex oligomerization), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006302 (double-strand break repair), GO:0042325 (regulation of phosphorylation), GO:0044773 (mitotic DNA damage checkpoint signaling), GO:0045893 (positive regulation of DNA-templated transcription), GO:0071103 (DNA conformation change), GO:0031297 (replication fork processing), GO:0051260 (protein homooligomerization), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0000724 (double-strand break repair via homologous recombination), GO:0032392 (DNA geometric change), GO:0032508 (DNA duplex unwinding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)