Protein: Receptor-type tyrosine-protein phosphatase V (P70289)
Organism: Mus musculus (Mouse)
Function: Protein tyrosine phosphatase that acts as a regulator of energy metabolism by mediating dephosphorylation of insulin receptor (Insr). Prevents decarboxylation of osteocalcin (Bglap and Bglap2) via an indirect mechanism: dephosphorylation of insulin receptor prevents insulin signaling- dependent decarboxylation of osteocalcin, preventing the hormone activity of osteocalcin. May play a role in the maintenance of pluripotency
Subcellular location: Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [1127-1699]
- IPR003961: Fibronectin type III (domain) [35-926]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [36-921]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [124-926]
- IPR050713: Receptor-type Tyrosine-protein Phosphatases/Ushers (family) [711-1410]
- IPR000242: Tyrosine-specific protein phosphatase, PTPase domain (domain) [1149-1695]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [1327-1400]
- IPR041201: PTPRJ, transmembrane domain (domain) [948-1068]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [1348-1358]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [1305-1694]
Sequence:
MRPLILLAALLWLQDSLAQEDVCSSLDGSPDRQGGGPPLSVSVTSRGRPTSLFLSWVAAEPGGFDYALCLRAMNLSGFPEGQQLQAHTNESSFEFHGLVPGSRYQLELTVLRPCWQNVTITLTARTAPTVVRGLQLHSTGSPASLEASWSDASGDQDSYQLLLYHPESHTLACNVSVSPDTLSYNFGDLLPGSQYVLEVITWAGSLHAKTSILQWTEPVPPDHLRVRALGTSSLQAFWNSSEGATWFHLILTDLLEGTNLTKVVRQGISTHTFLRLSPGTPYQLKICAAAGPHQIWGPNATEWTYPSYPSDLVLTPLWNELWASWKAGQGARDGYVLKLSGPVENTTTLGPEECNAVFPGPLPPGHYTLGLRVLAGPYDAWVEGSIWLAESAARPMEVPGARLWLEGLEATKQPGRRALLYSVDAPGLLGNISVSSGATHVTFCGLVPGAHYRVDIASSMGDITQSLTGYTSPLPPQSLEIISRNSPSDLTIGWAPAPGQMEGYKVTWHQDGSQRSPGDLVDLGPDISSLTLKSLVPGSCYTVSAWAWSGNLSSDSQKIHSCTRPAPPTNLSLGFAHQPATLRASWCHPPGGRDAFQLRLYRLRPLTLESEKILSQEAQNFSWAQLPAGYEFQVQLSTLWGSEESGSANTTGWTPPSAPTLVNVTSEAPTQLHVSWVHAAGDRSSYQVTLYQESTRTATSIVGPKADSTSFWGLTPGTKYKVEAISWAGPLYTAAANVSAWTYPLTPNELLASMQAGSAVVNLAWPSGPLGRGTCHAQLSDAGHLSWEQPLSLGQDLLMLRNLIPGHTVSLSVKCRAGPLQASTHPLVLSVEPGPVEDVFCQPEATYLSLNWTMPTGDVAVCLVEVEQLVPGGSAHFVFQVNTSEDALLLPNLTPTTSYRLSLTVLGGNRQWSRAVTLVCTTSAEVWHPPELAEAPQVELGTGMGVTVTRGMFGKDDGQIQWYGIIATINMTLAQPSQEAINHTWYDHYYRGHDSYLALLFPNPFYPEPWAVPRSWTVPVGTEDCDNTQEICNGHLKPGFQYRFSIAAFSRLSSPETILAFSAFSEPQASISLVAMPLTVMMGTVVGCIIIVCAVLCLLCRRGLKGPRSEKNGFSQELMPYNLWRTHRPIPSHSFRQSYEAKSARAHQAFFQEFEELKEVGKDQPRLEAEHPANITKNRYPHVLPYDHSRVRLTQLSGEPHSDYINANFIPGYSHPQEIIATQGPLKKTVEDFWRLVWEQQVHVIIMLTVGMENGRVLCEHYWPVNSTPVTHGHITTHLLAEESEDEWTRREFQLQHGAEQKQRRVKQLQFTTWPDHSVPEAPSSLLAFVELVQEEVKATQGKGPILVHCSAGVGRTGTFVALLPAVRQLEEEQVVDVFNTVYILRLHRPLMIQTLSQYIFLHSCLLNKILEGPSDASDSGPIPVMNFAQACAKRAANANAGFLKEYRLLKQAIKDETGSLLPSPDYNQNSIASCHHSQEQLALVEESPADNMLAASLFPGGPSGRDHVVLTGSAGPKELWEMVWEHGAYVLVSLGLPDTKEKPQDIWPMEMQPIVTDMVTVHRVAESNTAGWPSTLIRVIHGDSGTERQVQCLQFPHCETGSELPANTLLTFLDAVGQCCSRGNSKKPGTLLSHSSKVTNQLSTFLAMEQLLQQAGTERTVDVFSVALKQTQACAVKTPTLEQYIYLYNCLNSALRNRLPRARK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004725 (protein tyrosine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0008283 (cell population proliferation), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0065008 (regulation of biological quality), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0051051 (negative regulation of transport), GO:0032879 (regulation of localization), GO:0007049 (cell cycle), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0048878 (chemical homeostasis), GO:0044237 (cellular metabolic process), GO:0044238 (primary metabolic process), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:1903828 (negative regulation of protein localization), GO:0044248 (cellular catabolic process), GO:0048513 (animal organ development), GO:0044255 (cellular lipid metabolic process), GO:0071495 (cellular response to endogenous stimulus), GO:0010948 (negative regulation of cell cycle process), GO:0009725 (response to hormone), GO:0051048 (negative regulation of secretion), GO:0051726 (regulation of cell cycle), GO:0045786 (negative regulation of cell cycle), GO:1901575 (organic substance catabolic process), GO:0010564 (regulation of cell cycle process), GO:1903531 (negative regulation of secretion by cell), GO:0046888 (negative regulation of hormone secretion), GO:0010648 (negative regulation of cell communication), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:1903047 (mitotic cell cycle process), GO:0035556 (intracellular signal transduction), GO:0060341 (regulation of cellular localization), GO:0008285 (negative regulation of cell population proliferation), GO:0051224 (negative regulation of protein transport), GO:0019538 (protein metabolic process), GO:0033500 (carbohydrate homeostasis), GO:1901700 (response to oxygen-containing compound), GO:0010817 (regulation of hormone levels), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0048144 (fibroblast proliferation), GO:0046883 (regulation of hormone secretion), GO:0042127 (regulation of cell population proliferation), GO:0006629 (lipid metabolic process), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0050673 (epithelial cell proliferation), GO:0000278 (mitotic cell cycle), GO:1901652 (response to peptide), GO:0007346 (regulation of mitotic cell cycle), GO:0048145 (regulation of fibroblast proliferation), GO:0070201 (regulation of establishment of protein localization), GO:0007093 (mitotic cell cycle checkpoint signaling), GO:0072331 (signal transduction by p53 class mediator), GO:0044242 (cellular lipid catabolic process), GO:0016042 (lipid catabolic process), GO:0090278 (negative regulation of peptide hormone secretion), GO:0043412 (macromolecule modification), GO:0051223 (regulation of protein transport), GO:0090276 (regulation of peptide hormone secretion), GO:0045930 (negative regulation of mitotic cell cycle), GO:0048147 (negative regulation of fibroblast proliferation), GO:0050708 (regulation of protein secretion), GO:1904950 (negative regulation of establishment of protein localization), GO:1901701 (cellular response to oxygen-containing compound), GO:0071417 (cellular response to organonitrogen compound), GO:0000075 (cell cycle checkpoint signaling), GO:0044342 (type B pancreatic cell proliferation), GO:0006974 (cellular response to DNA damage stimulus), GO:0071310 (cellular response to organic substance), GO:0042770 (signal transduction in response to DNA damage), GO:1901699 (cellular response to nitrogen compound), GO:0002792 (negative regulation of peptide secretion), GO:0050709 (negative regulation of protein secretion), GO:0032880 (regulation of protein localization), GO:0036211 (protein modification process), GO:0043434 (response to peptide hormone), GO:0032870 (cellular response to hormone stimulus), GO:0010243 (response to organonitrogen compound), GO:0090087 (regulation of peptide transport), GO:1901987 (regulation of cell cycle phase transition), GO:0042593 (glucose homeostasis), GO:0051046 (regulation of secretion), GO:0031016 (pancreas development), GO:1901988 (negative regulation of cell cycle phase transition), GO:0046676 (negative regulation of insulin secretion), GO:0050796 (regulation of insulin secretion), GO:0044774 (mitotic DNA integrity checkpoint signaling), GO:0000077 (DNA damage checkpoint signaling), GO:0031570 (DNA integrity checkpoint signaling), GO:0030330 (DNA damage response, signal transduction by p53 class mediator), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:0071375 (cellular response to peptide hormone stimulus), GO:0032868 (response to insulin), GO:0002791 (regulation of peptide secretion), GO:1901653 (cellular response to peptide), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0044819 (mitotic G1/S transition checkpoint signaling), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:1902807 (negative regulation of cell cycle G1/S phase transition), GO:0032869 (cellular response to insulin stimulus), GO:2000134 (negative regulation of G1/S transition of mitotic cell cycle), GO:0031571 (mitotic G1 DNA damage checkpoint signaling), GO:0044773 (mitotic DNA damage checkpoint signaling), GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest), GO:2000045 (regulation of G1/S transition of mitotic cell cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)