Protein: Voltage-dependent L-type calcium channel subunit alpha (A0A8M9Q055)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death
Subcellular location: Cell membrane, sarcolemma, T-tubule. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Membrane; Multi- pass membrane protein. Perikaryon. Postsynaptic density membrane
InterPro domains:
Sequence:
MLRGLFSWRRLKHERLEEEVEVRFKGKLVSERELGYTHVRPGGSNYSSPSLAPVPSLNEDEHVGGGGGVLGLAPEHIPTPGAPLSWQAAIDAARQAKLMGTTGAPISTASSTQRKRQHYTKPKKQASTASTRPPRALLCLTLKNPIRRACINIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLCHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGGTSMGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHRTCFFYKDGHKGHIAEEKPAPCAPSSAHGRHCSPPNITQCMMGWEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENDDEGLDDDKPRNLSMPASENESVNTDNAPAGDMEGETCCTRMANRISKSKFSRYSRRWNRLCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHHQQPEWLTNVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKRQNSEKPPLEDEKKEEKIELKSITSDGETPTATKINIDEYTGEDNEEKNPYPVNDFPAGEDDEEEPEMPVGPRPRPLSDIQLKEKAVPMPQAKAFFIFSPSNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTSLLQFMFACIGVQLFKGKFFYCTDTSKQTQAECRGAYILYKDGNVGKPEKAQRSWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQSQSFNKAMNILNMLFTGLFTVEMILKLIAFKPRGYFSDPWNVFDFLIVIGSIIDVILSEINPADPSSSPPSSVVRPMGLQNTEDNARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDNSQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACSPNRPCEKGSEINHSSEDCGSHFAIFYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVAKIPPKTALSLQAGLRTLHDMGPEIRRAISGDLTVEEELERAMKETVCAASEDDIFRVKRSGGLFGNHVNYYHQSDGHVSFPQSFTTQRPLHISKSGSPGEAESPSHQKLVDSTFTPSSYSSSGSNANINNANNTAIGHRYPKPTVSTVDGQTGPPLTTIPLPRPTWCFPNKSSDSSDSRLPIIRREEASTDETYDETFLDERDQAMLSMDMLEFQDEESKQLAPMVEAEVGEERRPWQSPRRRAFLCPTALGRRSSFHLECLRKHNRPDVSQKTALPLHLVHHQALAVAGLSPLLRRSHSPTLFTRLCSTPPASPSGRSGGGPCYQPVPSLRLEGSGSYEKLNSSMPSVNCSSWYSDSNGNHSGRAQRPVSLTVPPVTRRDSISLAHGSAGSLVEAVLISEGLGRYAHDPSFIQVAKQEIAEACDMTMEEMENAADNILNANAPPNANGNLLPFIQCRDTGSQESRCSLSLGLSPATGSDGALEAELEESEGAGQRNSPLMEDEDMECVTSL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005262 (calcium channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005245 (voltage-gated calcium channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0051239 (regulation of multicellular organismal process), GO:0007154 (cell communication), GO:0086065 (cell communication involved in cardiac conduction), GO:0002027 (regulation of heart rate), GO:0086019 (cell-cell signaling involved in cardiac conduction), GO:0098660 (inorganic ion transmembrane transport), GO:0042391 (regulation of membrane potential), GO:0006810 (transport), GO:0044057 (regulation of system process), GO:0034220 (monoatomic ion transmembrane transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0090257 (regulation of muscle system process), GO:0006811 (monoatomic ion transport), GO:1903522 (regulation of blood circulation), GO:0001508 (action potential), GO:0006937 (regulation of muscle contraction), GO:0008016 (regulation of heart contraction), GO:0006812 (monoatomic cation transport), GO:0086001 (cardiac muscle cell action potential), GO:0035725 (sodium ion transmembrane transport), GO:0086010 (membrane depolarization during action potential), GO:0061337 (cardiac conduction), GO:0030001 (metal ion transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0030315 (T-tubule), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0005891 (voltage-gated calcium channel complex), GO:0034702 (ion channel complex), GO:0042383 (sarcolemma), GO:0034703 (cation channel complex), GO:0034704 (calcium channel complex)