Protein: Dysferlin isoform X4 (A0A8M9PNZ9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasmic vesicle membrane; Single-pass type II membrane protein. Membrane; Single-pass type II membrane protein
InterPro domains:
- IPR037724: Ferlin, fifth C2 domain (domain) [1601-1724]
- IPR037726: Ferlin, first C2 domain (domain) [11-137]
- IPR012968: FerIin domain (domain) [309-380]
- IPR037725: Ferlin, sixth C2 domain (domain) [1835-1966]
- IPR037721: Ferlin family (family) [219-2096]
- IPR037722: Ferlin, third C2 domain (domain) [386-546]
- IPR000008: C2 domain (domain) [1-1965]
- IPR012561: Ferlin B-domain (domain) [779-850]
- IPR037723: Ferlin, fourth C2 domain (domain) [1140-1268]
- IPR032362: Ferlin, C-terminal domain (domain) [1999-2090]
- IPR006614: Peroxin/Ferlin domain (domain) [864-1091]
- IPR055072: Ferlin, dsRNA-binding domain-like domain (domain) [1693-1781]
- IPR035892: C2 domain superfamily (homologous_superfamily) [2-1960]
- IPR012560: Ferlin A-domain (domain) [686-751]
- IPR037720: Ferlin, second C2 domain (domain) [224-332]
Sequence:
MLRCLLQRATNLRNVEKGERHSDPLASITFRGTKKKTKVIKNNVNPVWNEGFEWDLKGVPLDSGAELHVVVKDHEKMGRNRFLGECRVALRDVLNSPNLAATFTVSLVDTKRNSTGATITLQVSYIPPPGMTPIFQPPPQPEAQHTPVELDTVTVFSLDTMGEDDTESMLMMEVAEEPEPVPGPQGQDIGAPTAPPKKAPPNFNQGLKKKKRQSNKSPLSDKAQDLQVRLRIIEGRQLPGVNIKPVVKVTVGGQTKRTRIKKGNNPFFDETFFLNFFEKPSDLFDEPIFITVFDSKSLRKDSVIGEFKLDVGMVYNEHRHAILRKWLLLADPDDLSAGARGYLKVSMFVLAAGDEPPMDKKEGVEEKEDIEANLLRPAGLTLRGATFTLRVYRAEDLPQMDDALIDDVKHFLGFDTNRKNLVDPLVEVNFAGKTISSKILEKCANPQWNQCLTLPIRFPSMCEKMRIRILDWDRASHNDVIGTAHLCMSKISAPGGDIEVDDSIGFLPTFGPCFVNMYGSPREFTAFSDPHEALNLGKGEGVAYRGRVLLELITKLSDQVDQRSEDINSDDLLVVEKFMRKRKFSLFAAFYSATLLQDVDDAVQFEVSIGNYGNKFDNTCLPLASTTQFSRAVFDGCHYYYLPWGNVKPVVVVSSEWEDIGPRIEALNMLLSIVDRLESNLEQVQLELKARSDDQEVEQRVVQLLDDVIADCSEELPELDKWPCVTPLDKALRNLRKINMQQIVQAALALKHGPETELSAVLEQAEDWTMRLRYLSEEPQNSLPDIIIWMLQGDRRVAYHRIPAHQVLFSYGYCGKHCGQLQTVFMKCPQEDGGCSKIPAQLRIKVWFGLTADVKSFNQFAEGKLSVFAETYENQTKLALVGNWGTTGLTYPKFSDVTGRVKLPKESFKPSSGWSWAGEWFISPEKTMLYDADAGHISFLEEVFENQLRLPGGQWIGMPEGYTDVNGEKAVPKDEIECPPGWVWEDIEWSEDLKRAVDDQGWEYGITLPPDRRPKSWVPSEKMYHTNRRRRWIRLRRRDMQKMEALRKQRPDESEREGWEYASLFGWKFHLKQKKTDLFRRRRWRRRMEPLEKTGPAAIFALECSLSSFTDEKNDDKSVTTTFGVSRPTISCFFDSGTLYHLRCYLYQARDLLAMDKDSFSDAYAVVSFLHQSQKTVTVRNTLNPTWDQTLIFYEVEIFGDHLVTERSPPNIVVELYDQDTYGADEFMGRCVCQPSMASSPRLAWYPIQKAGNSAGDLLAAFELIRRDKPAVHHIPGQEGDIIPPSHIMDELVLPGFLSENQQQWPEDSDLPYPPPQREPNVYMVPQGIKPVLQRTAIEILAWGLRNLKSFQLASVTSPSLQVECGGSVVQSCVIRNIKKNPNFDVNILFIDVRLPKEELYMPPLVIKVIDNRQFGRKPVVGQCSVHSLNEFYFQPESLERDSTEEEFEVIAHTPRDDVLVDIDDKEPLIPGQADGTSSAIINISPSQSSLHQDEFMDWWSKFYASMGERTKCGSYLEKGFDMLQVYDRELEKTEGFEQFADFCQTFKLYRGRTQNDSEDPSVVGEFKGSFKIYPLPDDPSMPVPTRQFRKLPPNGIEECLVRIYIIQAFGLQPKDANGKCDPYVKITLGKKSVDDHDNYIPCTLEPVFGKMFELTCCLPLEKDLKITLYDYDMVTKDEKIGETIIDLENRFLSRHGARCGLPQSYCLSGINQWRDQLKPSQLLHRLCERRNYKLPVYKQDRIYFRGHEYTVADLDEGKPLNPHLGPVMERLALLVLRRHGLVPEHVETRPLYSPLQPDIEQGRLQMWVDLFPKSLGPPGPPFNITPRKAKKFFLRCIIWNTRDVILDDVSVTGEKMSDIYVKGWMHGHEENKQKTDVHYRSLGGEGNFNWRFLFPFHYLPAEQLCTIDKKEHFWSLDKVETKLPPKLTIQIWDNDKFSFDDFLGSLEMDLNHMLSPAKSPEKCGLEMLTQSQDKLVSLFEQKTVKGWWPCVCDKEDKKILAGKVEMSLEIVCEQEQDERPAGLGRDEPNMNPHLEEPQRPETSFLWFSSPYKTFRFIVWRRFKWLILGLFILFFIILFLGVFLYAFPNYAAMKMVGPFSGLGKGTQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0005543 (phospholipid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0009653 (anatomical structure morphogenesis), GO:0006950 (response to stress), GO:0016043 (cellular component organization), GO:0061061 (muscle structure development), GO:0009887 (animal organ morphogenesis), GO:0009611 (response to wounding), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0042060 (wound healing), GO:0048644 (muscle organ morphogenesis), GO:0007517 (muscle organ development), GO:0042692 (muscle cell differentiation), GO:0010256 (endomembrane system organization), GO:0055001 (muscle cell development), GO:0061024 (membrane organization), GO:0001778 (plasma membrane repair), GO:0007009 (plasma membrane organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030315 (T-tubule), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane), GO:0042383 (sarcolemma)