Protein: Fragile X messenger ribonucleoprotein 1 (A0A8I5KT56)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane. Cell projection, axon. Cell projection, dendrite. Cell projection, dendritic spine. Cell projection, filopodium tip. Cell projection, growth cone. Cell projection, neuron projection. Chromosome, centromere. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cytoplasm, Stress granule. Cytoplasm, perinuclear region. Membrane. Nucleus, nucleolus. Perikaryon. Presynaptic cell membrane. Synapse, synaptosome. Synaptic cell membrane
InterPro domains:
- IPR040472: Synaptic functional regulator FMRP, KH0 domain (domain) [123-207]
- IPR047431: Fragile X messenger ribonucleoprotein 1, first Tudor-like Agenet domain (domain) [1-55]
- IPR047438: Fragile X messenger ribonucleoprotein 1, first type I K homology domain (domain) [123-199]
- IPR041560: FMR1, tudor domain (domain) [4-115]
- IPR040148: Fragile X messenger ribonucleoprotein 1 (family) [1-552]
- IPR004087: K Homology domain (domain) [217-401]
- IPR008395: Agenet-like domain (domain) [63-117]
- IPR047440: Fragile X messenger ribonucleoprotein 1, second type I K homology domain (domain) [218-280]
- IPR004088: K Homology domain, type 1 (domain) [221-331]
- IPR047436: Fragile X messenger ribonucleoprotein 1, second Tudor-like Agenet domain (domain) [58-120]
- IPR022034: Fragile X messenger ribonucleoprotein 1-like, C-terminal core (domain) [399-470]
- IPR036612: K Homology domain, type 1 superfamily (homologous_superfamily) [216-404]
- IPR032196: Fragile X messenger ribonucleoprotein 1, C-terminal region 2 (domain) [503-569]
Sequence:
MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKENSTHFSQPNSTKVQRGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRGHGRRGPGYTSAPTEEERESFLRRGDGRRRGGGGRGQGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTTDGSLQNTSSEGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0045182 (translation regulator activity), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0097159 (organic cyclic compound binding), GO:0030371 (translation repressor activity), GO:1901363 (heterocyclic compound binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0042393 (histone binding), GO:0140693 (molecular condensate scaffold activity), GO:0042802 (identical protein binding), GO:0043021 (ribonucleoprotein complex binding), GO:0003676 (nucleic acid binding), GO:0140030 (modification-dependent protein binding), GO:0046983 (protein dimerization activity), GO:0044325 (transmembrane transporter binding), GO:0031369 (translation initiation factor binding), GO:0140666 (annealing activity), GO:0046982 (protein heterodimerization activity), GO:0140034 (methylation-dependent protein binding), GO:0043022 (ribosome binding), GO:0042803 (protein homodimerization activity), GO:0035064 (methylated histone binding), GO:0003677 (DNA binding), GO:0003723 (RNA binding), GO:0003727 (single-stranded RNA binding), GO:0003729 (mRNA binding), GO:0035613 (RNA stem-loop binding), GO:0061980 (regulatory RNA binding), GO:0048027 (mRNA 5'-UTR binding), GO:0070717 (poly-purine tract binding), GO:0008187 (poly-pyrimidine tract binding), GO:1990825 (sequence-specific mRNA binding), GO:0035197 (siRNA binding), GO:0035198 (miRNA binding), GO:0003730 (mRNA 3'-UTR binding), GO:0008266 (poly(U) RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048524 (positive regulation of viral process), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0044403 (biological process involved in symbiotic interaction), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0098900 (regulation of action potential), GO:0044237 (cellular metabolic process), GO:0060148 (positive regulation of post-transcriptional gene silencing), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0050792 (regulation of viral process), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0060998 (regulation of dendritic spine development), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044827 (modulation by host of viral genome replication), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0051702 (biological process involved in interaction with symbiont), GO:0044057 (regulation of system process), GO:0060255 (regulation of macromolecule metabolic process), GO:0060627 (regulation of vesicle-mediated transport), GO:0051130 (positive regulation of cellular component organization), GO:0098908 (regulation of neuronal action potential), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0051098 (regulation of binding), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:1900370 (positive regulation of post-transcriptional gene silencing by RNA), GO:0009891 (positive regulation of biosynthetic process), GO:0044087 (regulation of cellular component biogenesis), GO:0009894 (regulation of catabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1903900 (regulation of viral life cycle), GO:0006139 (nucleobase-containing compound metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0033554 (cellular response to stress), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0042391 (regulation of membrane potential), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0045807 (positive regulation of endocytosis), GO:0051128 (regulation of cellular component organization), GO:1903902 (positive regulation of viral life cycle), GO:0044260 (cellular macromolecule metabolic process), GO:0009615 (response to virus), GO:0030100 (regulation of endocytosis), GO:0098586 (cellular response to virus), GO:0031344 (regulation of cell projection organization), GO:0034250 (positive regulation of amide metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0051246 (regulation of protein metabolic process), GO:0031330 (negative regulation of cellular catabolic process), GO:0010628 (positive regulation of gene expression), GO:0048260 (positive regulation of receptor-mediated endocytosis), GO:0010468 (regulation of gene expression), GO:0060491 (regulation of cell projection assembly), GO:0051099 (positive regulation of binding), GO:0051851 (modulation by host of symbiont process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0034248 (regulation of amide metabolic process), GO:0051969 (regulation of transmission of nerve impulse), GO:0090304 (nucleic acid metabolic process), GO:0031644 (regulation of nervous system process), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0006259 (DNA metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:2000637 (positive regulation of miRNA-mediated gene silencing), GO:1902373 (negative regulation of mRNA catabolic process), GO:0048259 (regulation of receptor-mediated endocytosis), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0060966 (regulation of gene silencing by RNA), GO:0061013 (regulation of mRNA catabolic process), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:1903312 (negative regulation of mRNA metabolic process), GO:0043484 (regulation of RNA splicing), GO:0006281 (DNA repair), GO:1902369 (negative regulation of RNA catabolic process), GO:0002092 (positive regulation of receptor internalization), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0006417 (regulation of translation), GO:1903311 (regulation of mRNA metabolic process), GO:0044788 (modulation by host of viral process), GO:0045727 (positive regulation of translation), GO:0060147 (regulation of post-transcriptional gene silencing), GO:0010608 (post-transcriptional regulation of gene expression), GO:0048024 (regulation of mRNA splicing, via spliceosome), GO:0051489 (regulation of filopodium assembly), GO:0002090 (regulation of receptor internalization), GO:0050684 (regulation of mRNA processing), GO:1900368 (regulation of post-transcriptional gene silencing by RNA), GO:0060964 (regulation of miRNA-mediated gene silencing), GO:0000381 (regulation of alternative mRNA splicing, via spliceosome)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)