Protein: Serine/threonine-protein kinase ATR (A6I268)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus
InterPro domains:
- IPR021133: HEAT, type 2 (repeat) [741-775]
- IPR011989: Armadillo-like helical (homologous_superfamily) [534-1394]
- IPR036940: Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily (homologous_superfamily) [2354-2535]
- IPR003152: FATC domain (domain) [2539-2571]
- IPR056802: Serine/threonine-protein kinase ATR-like, M-HEAT region (domain) [1418-1639]
- IPR018936: Phosphatidylinositol 3-/4-kinase, conserved site (conserved_site) [2387-2407]
- IPR056803: Serine/threonine-protein kinase ATR-like, N-HEAT region (domain) [5-554]
- IPR050517: DNA Damage Response and Repair Kinase (family) [67-2570]
- IPR000403: Phosphatidylinositol 3-/4-kinase, catalytic domain (domain) [2223-2560]
- IPR057564: Serine/threonine-protein kinase ATR-like, HEAT repeats (domain) [2051-2149]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [1568-1980]
- IPR016024: Armadillo-type fold (homologous_superfamily) [237-1305]
- IPR012993: UME domain (domain) [1055-1161]
- IPR003151: PIK-related kinase, FAT (domain) [1702-2022]
- IPR014009: PIK-related kinase, FAT domain (domain) [1570-2115]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [2151-2494]
Sequence:
MGDHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVALELVKKTDTQPTSVMLLDFIQHIMKSSPLMFVNVNGSQGQNEAKDSCIEFSHWIITRLLRIAATPSCHMLHKKICEVICSLLFLFKSKNPAIFGVLTRELLYLFEDLIYLHKRNAVGDVMEWPVVVSRFLSRLDEHMGCLQPAPLQFMNMQNVEFIEVTLLMVLIHIVPTVFFRRQELLLWQIGCALLEHGSPKIRSLAISLLTELFELGGLPAQPASTFFSLFLELLQHLIGMDADQLKLYEEPLSKLVKTLFPFEAEAYRNIEPVYLNVLLEKLRVMFEDRVLMRLKSDLLKAALCHLLQYFLTFVPAGYESALQVRKVYVTDICRALVDVLGVQTHVGYLLGPFYAALKMESTEIIERIQCQAQQENLRGSNDGVSPKRRRLSSSLSSYKRPSRQSEEINHVDMDKKSILWNVLKQKAESLQISLECGTLKNSVAEALEGITIVLQLTALCTVHCSHQDMDGHNAKDCQHKYKKKPPVVITWMSLDFYTKVLKSCKSLLESVQKHELELVIDSVVRIYDALMYIQVKSSFQDHVLEELCGMLSLPWIYSYSDDNSLKMTTFATNLLRLSQRVWESYYRVKDDSHVVKKEFASVLGQLVCTLHGMFYLTSSSVEPFFGPVDLFCKNLKATSQHECSSSQVKASVCKPFLFLLTKNTPSPVKLAFIDNLHHLCKHLDFQEDETEVKAVLGTLLNLMEDPDKDVRIAFSGNIKYILESLNSEDGFIKELFVLRMKEAYTHAQISRSNELKDTLILTTGDIGRAAKGDLIPFALLHLLHCLLSKSASVSGAAYTEIRALVAAKSVKLQNFFSQYKKPICQFLVESLHSSQMTALPSTPCQTAEMRKQHVAHHREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDITSPELMADYLQPKLLGILAFFNMQLLSSSVGIEDKKMALTSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLDHAYLGPLLSHVIVALLPLIQMQPKETAAIFHYLIIENRVAVQDFLHEIYFLPDHPELEKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIKYATDSETVEPVISQLVTVILKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKDFTFVTGVEDLSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMQSNGPGHQLWKRFPEHVREILEPHLNTRYKSSQKSTDWSGVTKPIYLSKLGNNFAEWSSSWAGYLITKVRDNLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCSQEDQQEVYAEIMAVLKHDDQHAISTQDSASDLCQLSTQTVFSMLDHLTQWARHKFQALNAEKLAQNKPKGVSSVNFEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQKHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESIGLLRDATACYDRAIQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDTTAFYDTLKLVRAEQIVPLSAASFERGSYQRGYEFIVRLHMLCELEHSLKPLFHKFPGDSCNEDSLNWAARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGVELCFPENKSPTESKHMLIHGRATLLVGRFMEETANFESNAIMKKYKDVTLFLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLSLWLDFGAKAYEWEKGGRSDRLQMRNDLAKINSVLTEHTNRLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILTKAIHMKKSLEKFVGDATRLTDKLLELCNKSVDGSNSTLSMSTHFKMLKKLVEDPTFSEILIPLQSVMIPTLPSILGAHANHDPFPGHWAYLAGFDDVVEILSSLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFQEILLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTLRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPPNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0044877 (protein-containing complex binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0009410 (response to xenobiotic stimulus), GO:0046685 (response to arsenic-containing substance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)