Protein: Similar to Caspase recruitment domain protein 4 (Predicted) (A6K0W2)
Organism: Rattus norvegicus (Rat)
Function: Regulatory part that prevents formation of the Nlrp1a inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of Nlrp1a (NACHT, LRR and PYD domains-containing protein 1a, C-terminus), preventing activation of the Nlrp1a inflammasome. In response to pathogen-associated signals, this part is ubiquitinated by the N-end rule pathway and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the Nlrp1a inflammasome
Subcellular location: Basolateral cell membrane. Cell membrane; Lipid-anchor. Cytoplasm, cytosol. Inflammasome. Lateral cell membrane. Membrane; Lipid-anchor
InterPro domains:
- IPR011029: Death-like domain superfamily (homologous_superfamily) [9-107]
- IPR007111: NACHT nucleoside triphosphatase (domain) [196-531]
- IPR041075: NOD1/2, winged helix domain (domain) [459-515]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [676-949]
- IPR041267: NACHT, LRR and PYD domains-containing protein, helical domain HD2 (domain) [517-666]
- IPR001611: Leucine-rich repeat (repeat) [786-889]
- IPR001315: CARD domain (domain) [21-104]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [120-338]
- IPR051261: NOD-like receptor (family) [193-871]
Sequence:
MEKRGQHEMEGVPAGCHSHIKLLRINREHLVTNIRNTQCLVDNLLENGYFSAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYVLQQLEDAYVDLRLWLSEIGFSPSQLIRTKTIVNTDPVSRYTQQLRHQLGRDSKFMLCYAQKEDLLLEETYMDTLMELVGFNNENLGSLGGLDCLLDHSTGVLNEHGETVFVFGDAGVGKSMLLQRLQSLWASGRLASKAKFFFHFRCRMFSCFKESDTLTLQDLLFKHFCYPEQDPEEVFSFLLRFPHTALFTFDGLDELHSDFDMSRVPDSCCPWEPAHPLVLLANLLSGRLLKGAGKLLTARTGVEVPRQLLRKKVLLRGFSPSHLRAYARRMFPERTAQEHLLQQLDANPNLCSLCGVPLFCWIIFRCFQHFHTAFEGSSQLPDCAVTLTDVFLLVTEVHLNRTQPISLMQRNTRSPAETLRAGWRTLQALGEVAHRGTDRSLFVFGQEEVQASKLQEGDLQLGFLRALPDVGPEQSQQSYEFFHLTLQAFFTAFFLVADDKVSTQELLRFFREWTSPGEATSRSCYPSFFSFQCLGSGSRLGPDPFKNKDHFQFTNLFLCGLLAKARQKLLQQLVPKAILRKKRKALWAHLFASLRSYLKSLPRVQSDGFNQVHAMPTFLWMLRCIYETQSQKVGRLAARGISADYLKLAFCNACSADCSALSFVLHHFHRQLALDLDNNNLNDYGVRELQPCFSRLTVIRLSVNQITDMGVKVLCEELTKYKIVTFLGLYNNQITDIGARYVAQILDECRGLTHLKLGKNRITSEGGRCVAQAVKNSTSIVEVGMWGNQIGDEGAKAFAEALRDHPSLTTLSLAFNGISPEGGKSLAQALKQNTTLTIIWLTKNELNDEAAECFAEMLRVNQTLKHLWLIQNHITAEGTAQLARALQKNTTITEICLNGNLIKPEEAKVFENEKRIICF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0033218 (amide binding), GO:0097367 (carbohydrate derivative binding), GO:0042277 (peptide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0051239 (regulation of multicellular organismal process), GO:0048522 (positive regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0010942 (positive regulation of cell death), GO:0044093 (positive regulation of molecular function), GO:0010941 (regulation of cell death), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0001819 (positive regulation of cytokine production), GO:0001817 (regulation of cytokine production), GO:1903555 (regulation of tumor necrosis factor superfamily cytokine production), GO:0051341 (regulation of oxidoreductase activity), GO:0032732 (positive regulation of interleukin-1 production), GO:1903557 (positive regulation of tumor necrosis factor superfamily cytokine production), GO:0010628 (positive regulation of gene expression), GO:0032652 (regulation of interleukin-1 production), GO:0043085 (positive regulation of catalytic activity), GO:0010468 (regulation of gene expression), GO:0051353 (positive regulation of oxidoreductase activity), GO:0032760 (positive regulation of tumor necrosis factor production), GO:0032680 (regulation of tumor necrosis factor production), GO:0032768 (regulation of monooxygenase activity), GO:0032731 (positive regulation of interleukin-1 beta production), GO:0032651 (regulation of interleukin-1 beta production), GO:0032770 (positive regulation of monooxygenase activity), GO:0050999 (regulation of nitric-oxide synthase activity), GO:0051000 (positive regulation of nitric-oxide synthase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)