Protein: 5'-3' exoribonuclease 1 (A6I270)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm
InterPro domains:
- IPR027073: 5'-3' exoribonuclease (family) [1-1178]
- IPR047008: 5'-3' exoribonuclease 1, SH3-like domain superfamily (homologous_superfamily) [1088-1187]
- IPR041412: Xrn1, helical domain (domain) [272-597]
- IPR041106: Exoribonuclease Xrn1, D2/D3 domain (domain) [850-1075]
- IPR016494: 5'-3' exoribonuclease 1 (family) [1-1683]
- IPR040992: 5'-3' exoribonuclease 1, D1 domain (domain) [654-844]
- IPR004859: Xrn1, N-terminal (domain) [1-227]
- IPR041385: 5'-3' exoribonuclease 1, SH3-like domain (domain) [1102-1171]
- IPR047007: 5'-3' exoribonuclease 1, D1 domain superfamily (homologous_superfamily) [662-845]
Sequence:
MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKIFTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGETLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKSWQGVTIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCAPEETTFHLLHLSLMREYIDYEFSALKEKITFKYDIEKIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYIAILPELGGYINESGHLNLPRFERYLVKLSDFDREHFSEVFVDLKWFESKVGNKYLNEAAGAAAEEAKSCKDKRKVKGQENSLSWAALDKREGEGVASRDNFEDETEDDDLFETEFRQYKRTYYMTKMGVDVVSDEFLADQAACYVQAIQWILHYYYHGVQSWSWYYPYHYAPFLSDIRNISTLKIHFELGKPFKPFEQLLAVLPSASKTLLPTCYQHLMTSEDSPIIEYYPPDFKTDLNGKQQEWEAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDSDTEFTYSSPWPEKFPAIERCSTRYKIISLDAWRVDINKNKITRVDQKALYFCGFPTLKHIKHKFFLKKSGVQVFQQSSRGENMMLEITVNAEPDELSIENIASSVLGKSVFVNWPHLEEARVVAVSDGETKFYMEEPPGTQKVYLGKTAPPCKVIQLSDKEQSNWTKEIQGISEQYLRRKGIMINETSAVVYAQLLTGRRYQVNQNGEVRLEKQWSKQSLPFVYQTIVKDVRAFDSRFSNIKTLDDLFPPRSVVFMLGTPYYGCTGEVQDSGDVITEGRIRVVFSIPCEPNLDALIQNQHKYSIKYNPGYVLAGRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFNKKNEEVPGYTKRVGSEWMYSSAAEQLLAEYIERAPELFSYIAQNSQEDVFYEDDIWPGESESGAEKVQEIITWLKGHPVSTLSRSSCDLHILDAAIVEKIEEEVEKCKQRKNNKKVRVTVKPHLLFRPLEQQHGAIPDRDAEFRLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLFEVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRCETGNQKLTAIVKPQPAVSHCSVNSSVSSGHMGGLNHSPQSLFLPTQVPTKGDDEFCNIWQSLQGSGKIQHLQPTVQEKGAVLPQEISQVTESHKSGFNDHSVRHQQRKHDPHRKFKEEYKSPKAECQNQKLSNKQTSGASARCNIKLLKRNESPGTSEAQKVVTSYPNAVHKPHSGIESFLASLNISKESEVQLPHGEPPDEAHLSPQSFAMKGTRMLKEILKIDSPDTTDSKNDVKKFDNEVMVSSSRRDEHGPSSHPKPSKKLASHVSQPHSTNEYQSVDSVCWPGHMPPVSTPVTELSRICSLVGMPQPDFSFLRTTQGSLGVNFPLPPPIFTNYPPAVPPGAVPPVFPQPTANMMPSSSHLFGSVPWRPPVPVPGNAYHYPSYPATMPLAGGMPGGVHNQFIPLQVTKKRVANKKNFENKEAQSSQATPLQTNKPGSSEATRMTPQEGSPASSASSQATQPVSSHVETASQGHVVSHQRSAPSSSRRKSRKLAVNFSVSKPSE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0003677 (DNA binding), GO:0003723 (RNA binding), GO:0004540 (ribonuclease activity), GO:0004532 (exoribonuclease activity), GO:0004527 (exonuclease activity), GO:0016896 (RNA exonuclease activity, producing 5'-phosphomonoesters), GO:0008409 (5'-3' exonuclease activity), GO:0016796 (exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters), GO:0004534 (5'-3' RNA exonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0010605 (negative regulation of macromolecule metabolic process), GO:1902074 (response to salt), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0071417 (cellular response to organonitrogen compound), GO:0097305 (response to alcohol), GO:1901654 (response to ketone), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0071310 (cellular response to organic substance), GO:1902075 (cellular response to salt), GO:0051248 (negative regulation of protein metabolic process), GO:1901699 (cellular response to nitrogen compound), GO:0010468 (regulation of gene expression), GO:0034248 (regulation of amide metabolic process), GO:0010243 (response to organonitrogen compound), GO:0033993 (response to lipid), GO:0031326 (regulation of cellular biosynthetic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0010629 (negative regulation of gene expression), GO:0034249 (negative regulation of amide metabolic process), GO:1901655 (cellular response to ketone), GO:0017148 (negative regulation of translation), GO:0071407 (cellular response to organic cyclic compound), GO:0046898 (response to cycloheximide), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0006417 (regulation of translation), GO:0014074 (response to purine-containing compound), GO:0097306 (cellular response to alcohol), GO:2000113 (negative regulation of cellular macromolecule biosynthetic process), GO:0033574 (response to testosterone), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0043025 (neuronal cell body), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043228 (non-membrane-bounded organelle), GO:0043005 (neuron projection), GO:0000932 (P-body), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0030425 (dendrite)