Protein: Lysine-specific histone demethylase (A6ITB7)
Organism: Rattus norvegicus (Rat)
Function: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity
Subcellular location: Nucleus
InterPro domains:
- IPR050281: Flavin monoamine oxidase and related enzymes (family) [114-757]
- IPR017366: Lysine-specific histone demethylase (family) [7-763]
- IPR002937: Amine oxidase (domain) [212-749]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [201-765]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [96-200]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [95-201]
- IPR007526: SWIRM domain (domain) [98-197]
Sequence:
METGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGQAGGLQDDSSGGYGDGQASGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPIKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0021700 (developmental maturation), GO:0065009 (regulation of molecular function), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0021987 (cerebral cortex development), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0021537 (telencephalon development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0009636 (response to toxic substance), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0051130 (positive regulation of cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0051098 (regulation of binding), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0071695 (anatomical structure maturation), GO:1901360 (organic cyclic compound metabolic process), GO:1901698 (response to nitrogen compound), GO:0060322 (head development), GO:0031325 (positive regulation of cellular metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0048469 (cell maturation), GO:0070887 (cellular response to chemical stimulus), GO:0030900 (forebrain development), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0046677 (response to antibiotic), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0021543 (pallium development), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0071417 (cellular response to organonitrogen compound), GO:0046683 (response to organophosphorus), GO:0032535 (regulation of cellular component size), GO:0060992 (response to fungicide), GO:0042551 (neuron maturation), GO:0009112 (nucleobase metabolic process), GO:0031344 (regulation of cell projection organization), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0071310 (cellular response to organic substance), GO:1901699 (cellular response to nitrogen compound), GO:0072521 (purine-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:0048666 (neuron development), GO:0051099 (positive regulation of binding), GO:0036211 (protein modification process), GO:0007420 (brain development), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051591 (response to cAMP), GO:0022008 (neurogenesis), GO:0051254 (positive regulation of RNA metabolic process), GO:0043412 (macromolecule modification), GO:0010243 (response to organonitrogen compound), GO:0007399 (nervous system development), GO:0031346 (positive regulation of cell projection organization), GO:0035561 (regulation of chromatin binding), GO:0090304 (nucleic acid metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0007417 (central nervous system development), GO:0014070 (response to organic cyclic compound), GO:0051252 (regulation of RNA metabolic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0030182 (neuron differentiation), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010467 (gene expression), GO:0006144 (purine nucleobase metabolic process), GO:0016070 (RNA metabolic process), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0035563 (positive regulation of chromatin binding), GO:2001141 (regulation of RNA biosynthetic process), GO:0010976 (positive regulation of neuron projection development), GO:0006355 (regulation of DNA-templated transcription), GO:0071320 (cellular response to cAMP), GO:0008361 (regulation of cell size), GO:0006396 (RNA processing), GO:0071407 (cellular response to organic cyclic compound), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0048699 (generation of neurons), GO:0014074 (response to purine-containing compound), GO:0016570 (histone modification), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0045793 (positive regulation of cell size), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0010975 (regulation of neuron projection development), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000380 (alternative mRNA splicing, via spliceosome), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:0005694 (chromosome)