Protein: Sodium/potassium exporting P-type ATPase 2 (O13398)
Organism: Schwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)
Function: Catalyzes the hydrolysis of ATP coupled with the export of sodium and potassium from the cell. May be an inefficient sodium exporter. May transport other cations such as lithium (By similarity). Sodium/potassium efflux ATPases are involved in salt tolerance and maintaining the membrane potential across the plasma membrane in high salinity (Na+) or alkaline (K+) environments
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR023214: HAD superfamily (homologous_superfamily) [388-791]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [393-399]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [397-646]
- IPR006068: Cation-transporting P-type ATPase, C-terminal (domain) [836-1038]
- IPR006414: P-type ATPase, subfamily IID (family) [34-1042]
- IPR044492: P-type ATPase, haloacid dehalogenase domain (domain) [373-798]
- IPR059000: P-type ATPase, A domain (domain) [141-257]
- IPR001757: P-type ATPase (family) [113-827]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [32-1043]
- IPR004014: Cation-transporting P-type ATPase, N-terminal (domain) [32-106]
- IPR036412: HAD-like superfamily (homologous_superfamily) [390-855]
- IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [143-256]
Sequence:
MSSINTNVAEKHSYKERVNTDASSLSADGSVEAHRLTIEQVAKIFNTDIINGLSTSQANQTLKDFGANTLGDGDKISLTKIIAHQVCNAMILVLIISMVIALAIKDWISGGVIGFVVLINISVGFVQEYKAEKTMGSLRSLSSPTARVTRNGDDTTIPAEEVVPGDIVHIKVGDTVPADLRLIDLMNLETDEALLTGESLPITKNHLDVYDDYSVPIPVGDRLNLAYSSSVVSKGRGTGIVIATALDTQIGQIAKSLRNNNSVIRKVDKSNGKPKKREYSKAFCGTIKDIFYNILGINVGTPLQRKLSWLAIFLFWGCRYFCNYCNGIPKNRVNKEVAIYAICVALSMIPSALIVVLTITMAVGAQVMVMKHVIVRKLDSLEALGGINDICSDKTGTLTQGKMIARKTWIPNVGTFNVGNSNDPFNPKAGEVSFVNLSPKFIEETDEEIDFKQKLPSPFPENFNNWLLTATLANIATLNQSRDEETGELVWKAHGDATEIAIQVFTSRLNYGRDSLIENYEHLAEFPFDSSIKRMSAVYQSLQTNQIKVYTKGAVERVLNCCTHWYGHEENDELYDNQQLKELTDDDKHLIESNMNALSTQGLRVLAFATKDITNSSIDLSNRESIESNLIFQGLIGIYDPPRPETAGSVKSCHNAGINVHMLTGDHPGTAKAIAQEVGILPHNLYHYSEEVVKAMCMTANEFDSLSDDEIDKLPVLPLVIARCAPQTKVRMIEALHRRGKFVAMTGDGVNDSPSLKKADVGIAMGLNGSDVAKDASDIVLTDDNFASILNAIEEGRRMSSNIQKFVLQLLAENVAQALYLMVGLAFIDDSGLSVFPLSPVEVLWILVVTSCFPAMDLGQERASDDILEESPNSTIFTWEVIIDMIVYGFWMAVCCLVCFVIIVYGEGDPYLGVNCNKSSSSNSDVCELVFRGRSASFATMTWCALILAWECIHPYNSLFYMRQDTDHPWWKQTVIDLWDNQFLFWSVAIGFISVFPVVYIPVINTKVFLHGPIGYEWGLAVGFSILFLAGSELWKWIKRIHKRKANKKAKNPEYELERSDPFKKYASFSRSNTMDRPELMV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0140358 (P-type transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:0008556 (P-type potassium transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015662 (P-type ion transporter activity), GO:0005388 (P-type calcium transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0006970 (response to osmotic stress), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0048545 (response to steroid hormone), GO:0097305 (response to alcohol), GO:0009651 (response to salt stress), GO:0009737 (response to abscisic acid), GO:0014070 (response to organic cyclic compound), GO:0033993 (response to lipid), GO:0006972 (hyperosmotic response), GO:0031960 (response to corticosteroid), GO:0042538 (hyperosmotic salinity response), GO:0051414 (response to cortisol), GO:0051384 (response to glucocorticoid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)