Protein: V-type proton ATPase subunit H (A6JFI5)
Organism: Rattus norvegicus (Rat)
Function: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments
InterPro domains:
- IPR011989: Armadillo-like helical (homologous_superfamily) [8-350]
- IPR038497: ATPase, V1 complex, subunit H, C-terminal domain superfamily (homologous_superfamily) [362-464]
- IPR011987: ATPase, V1 complex, subunit H, C-terminal (domain) [349-464]
- IPR004908: ATPase, V1 complex, subunit H (family) [9-469]
- IPR016024: Armadillo-type fold (homologous_superfamily) [10-465]
Sequence:
MTKMDIRGAVDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISAEDCEFIQRFEMKRCSEEKQEMLQTEGSQCAKTFINLMTHISKEQTVQYILTMVDDMLQENHQRVSIFFDYAKRSKSTAWPYFLPMLNRQDPFTVHMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGSGVAVETGTISASDSSQYVQCVAGCLQLMLRVNEYRFAWVEADGVNCIMGVLSNKCGFQLQYQMIFSIWLLAFSPQMCEHLRRYNIIPVLSDILQESVKEKVTRIILAAFRNFLEKSTERETRQEYALAMIQCKVLKQLENLEQQKYDDEDISEDIKFLLEKLGESVQDLSSFDEYSSELKSGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTKLLEVSDDPQVLAVAAHDVGEYVRHYPRGKRVIEQLGGKQLVMNHMHHEDQQVRYNALLAVQKLMVHNWEYLGKQLQSEQPQTAAARS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051050 (positive regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0034762 (regulation of transmembrane transport), GO:0034764 (positive regulation of transmembrane transport), GO:0051049 (regulation of transport), GO:0048839 (inner ear development), GO:0043270 (positive regulation of monoatomic ion transport), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0034767 (positive regulation of monoatomic ion transmembrane transport), GO:0043269 (regulation of monoatomic ion transport), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0007423 (sensory organ development), GO:0043583 (ear development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0019898 (extrinsic component of membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0030054 (cell junction), GO:0031090 (organelle membrane), GO:0008021 (synaptic vesicle), GO:0031312 (extrinsic component of organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0030133 (transport vesicle), GO:0070382 (exocytic vesicle), GO:0030672 (synaptic vesicle membrane), GO:0030658 (transport vesicle membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0098850 (extrinsic component of synaptic vesicle membrane), GO:0099501 (exocytic vesicle membrane), GO:0097708 (intracellular vesicle)