Protein: Peroxisome proliferator-activated receptor gamma (A0A804HL89)
Organism: Homo sapiens (Human)
Function: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR003077: Peroxisome proliferator-activated receptor gamma (family) [6-152]
- IPR000536: Nuclear hormone receptor, ligand-binding domain (domain) [159-367]
- IPR013088: Zinc finger, NHR/GATA-type (homologous_superfamily) [57-150]
- IPR003074: Peroxisome proliferator-activated receptor (family) [149-324]
- IPR035500: Nuclear hormone receptor-like domain superfamily (homologous_superfamily) [157-353]
- IPR001628: Zinc finger, nuclear hormone receptor-type (domain) [57-131]
- IPR050234: Nuclear hormone receptor family NR1 subfamily (family) [38-347]
- IPR001723: Nuclear hormone receptor (family) [120-341]
Sequence:
DIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGERKIRGQSNLWFLPPRFAECEAH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0038023 (signaling receptor activity), GO:0043167 (ion binding), GO:0033218 (amide binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0004879 (nuclear receptor activity), GO:0042802 (identical protein binding), GO:0043621 (protein self-association), GO:0043169 (cation binding), GO:0008092 (cytoskeletal protein binding), GO:0003676 (nucleic acid binding), GO:0004888 (transmembrane signaling receptor activity), GO:0098531 (ligand-activated transcription factor activity), GO:0046332 (SMAD binding), GO:0042277 (peptide binding), GO:0019904 (protein domain specific binding), GO:0019899 (enzyme binding), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0004930 (G protein-coupled receptor activity), GO:0046872 (metal ion binding), GO:0140297 (DNA-binding transcription factor binding), GO:0003677 (DNA binding), GO:0001221 (transcription coregulator binding), GO:0042805 (actinin binding), GO:0070412 (R-SMAD binding), GO:0051393 (alpha-actinin binding), GO:0043565 (sequence-specific DNA binding), GO:0004953 (icosanoid receptor activity), GO:0046914 (transition metal ion binding), GO:0000976 (transcription cis-regulatory region binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0003690 (double-stranded DNA binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0004954 (prostanoid receptor activity), GO:0016922 (nuclear receptor binding), GO:0097677 (STAT family protein binding), GO:0008270 (zinc ion binding), GO:0042974 (nuclear retinoic acid receptor binding), GO:0004955 (prostaglandin receptor activity), GO:0046965 (nuclear retinoid X receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0048519 (negative regulation of biological process), GO:1905953 (negative regulation of lipid localization), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0051050 (positive regulation of transport), GO:0065008 (regulation of biological quality), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0009058 (biosynthetic process), GO:0051051 (negative regulation of transport), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0032370 (positive regulation of lipid transport), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0006725 (cellular aromatic compound metabolic process), GO:0009725 (response to hormone), GO:0045184 (establishment of protein localization), GO:0034763 (negative regulation of transmembrane transport), GO:0010876 (lipid localization), GO:1901360 (organic cyclic compound metabolic process), GO:0009755 (hormone-mediated signaling pathway), GO:0032410 (negative regulation of transporter activity), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0051128 (regulation of cellular component organization), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010888 (negative regulation of lipid storage), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:1901576 (organic substance biosynthetic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:1905952 (regulation of lipid localization), GO:0032409 (regulation of transporter activity), GO:0046483 (heterocycle metabolic process), GO:0044092 (negative regulation of molecular function), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0034641 (cellular nitrogen compound metabolic process), GO:0030522 (intracellular receptor signaling pathway), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0032411 (positive regulation of transporter activity), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0032369 (negative regulation of lipid transport), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0048545 (response to steroid hormone), GO:0071702 (organic substance transport), GO:0010743 (regulation of macrophage derived foam cell differentiation), GO:0032368 (regulation of lipid transport), GO:0010468 (regulation of gene expression), GO:0090304 (nucleic acid metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:1901701 (cellular response to oxygen-containing compound), GO:0010467 (gene expression), GO:0030100 (regulation of endocytosis), GO:0043086 (negative regulation of catalytic activity), GO:0071310 (cellular response to organic substance), GO:0019438 (aromatic compound biosynthetic process), GO:0051248 (negative regulation of protein metabolic process), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0032870 (cellular response to hormone stimulus), GO:0033993 (response to lipid), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0014070 (response to organic cyclic compound), GO:0051338 (regulation of transferase activity), GO:0051253 (negative regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0051174 (regulation of phosphorus metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0071222 (cellular response to lipopolysaccharide), GO:0016070 (RNA metabolic process), GO:0032371 (regulation of sterol transport), GO:0042304 (regulation of fatty acid biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0043549 (regulation of kinase activity), GO:0051348 (negative regulation of transferase activity), GO:1902680 (positive regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0031401 (positive regulation of protein modification process), GO:0042058 (regulation of epidermal growth factor receptor signaling pathway), GO:0043408 (regulation of MAPK cascade), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0006355 (regulation of DNA-templated transcription), GO:0071407 (cellular response to organic cyclic compound), GO:0019220 (regulation of phosphate metabolic process), GO:0071396 (cellular response to lipid), GO:0001932 (regulation of protein phosphorylation), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0045892 (negative regulation of DNA-templated transcription), GO:0045859 (regulation of protein kinase activity), GO:0016071 (mRNA metabolic process), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0042325 (regulation of phosphorylation), GO:0045893 (positive regulation of DNA-templated transcription), GO:0033674 (positive regulation of kinase activity), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0010875 (positive regulation of cholesterol efflux), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0006366 (transcription by RNA polymerase II), GO:0009299 (mRNA transcription), GO:0042789 (mRNA transcription by RNA polymerase II), GO:0045860 (positive regulation of protein kinase activity), GO:0071902 (positive regulation of protein serine/threonine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)