Protein: Complement component 4, gene 2 (A0A9K3Y872)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell projection, axon. Cell projection, dendrite. Secreted. Synapse
InterPro domains:
- IPR008930: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (homologous_superfamily) [992-1314]
- IPR048847: Complement C4, MG1 domain (domain) [23-132]
- IPR011625: Alpha-2-macroglobulin, bait region domain (domain) [470-609]
- IPR008993: Tissue inhibitor of metalloproteinases-like, OB-fold (homologous_superfamily) [1581-1737]
- IPR019742: Alpha-2-macroglobulin, conserved site (conserved_site) [1002-1010]
- IPR041555: Macroglobulin domain MG3 (domain) [233-319]
- IPR011626: Alpha-macroglobulin-like, TED domain (domain) [979-1310]
- IPR001599: Alpha-2-macroglobulin (domain) [778-866]
- IPR050473: Alpha-2-macroglobulin/Complement system (family) [11-1594]
- IPR001134: Netrin domain (domain) [1588-1735]
- IPR018933: Netrin module, non-TIMP type (domain) [1607-1719]
- IPR018081: Anaphylatoxin, complement system (homologous_superfamily) [680-749]
- IPR036595: Alpha-macroglobulin, receptor-binding domain superfamily (homologous_superfamily) [1447-1583]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [364-931]
- IPR040839: Macroglobulin domain MG4 (domain) [368-445]
- IPR009048: Alpha-macroglobulin, receptor-binding (domain) [1474-1563]
- IPR047565: Alpha-macroglobulin-like, thiol-ester bond-forming region (conserved_site) [994-1023]
- IPR002890: Macroglobulin domain (domain) [139-231]
- IPR000020: Anaphylatoxin/fibulin (domain) [684-752]
- IPR001840: Anaphylatoxin, complement system domain (domain) [696-736]
Sequence:
MRLLWGLAWAFSFFASSLQKPRLLLFSPSVVNLGTPLSVGVQLLDAPAGQEVKGSVYLRNPTSGPCSPKKDFKLSSGNDFVLLRLEVPLEDVRNCGLFDLRRAPHIQLVAYSPWLKNTAPKATETQGVNLLFSSRRGHIFVQTDQPIYNPGQRVRYRVFALDQKMRPSTDTLTVTVENSHGLRVRKKVVFAPTSIFTDDFVIPDISEPGTWKISARFSDGLESNRSTHFEVKKYVLPNFEVKLTPWKPYILTVPSYREEIQLDIQARYVYGKPVQGVAYTRFALMDEQGKKTFLRGLETQTKLVEGQTHISISRDQFQAALGKVNTEIGDLEGLRLYAAVAVIESPGGEMEEAELTSWPFVSSAFSLDLSHTKQHLVPGAPFLLQALVREMSGSEASDVPVKVSATLLSGSDSKVLDFQQNTNGIGQVSFSIHVPPTITELRLLVSAGSLYPAVAKLTVQAPPSRGPGFLSIEPLDLRSPRVGDTFILNLRTVGIPVPTFSHYYYMIISRGQIMAMSREPRTTLTSISVLVDHHLAPSFYFVAYFYHQGLPVANSLLINVQPGDCEGKLELKVDGAKEYRNGESMKLQLQTDSEALVALGAVDTALYAVGGRSHKPLDMSKVFEVMNSYNLGCGPGGGDDALQVFQTAGLAFSDGDRLTQTKEDLSCPKEKISRQKRNVNFQKAISEKLGQYSSPDTKRCCQDGMTKLPMARTCEQRAARVPQPACREPFLSCCKFAEDLRRNQTRSQAGLARAQNVMQEEDLIDEDDILVRSFFPENWLWKVEPVDRSKLLTVWLPDSLTTWEIHGVSLSKSKGLCVAKPTRVRVFREFHLHLRLPISVRRFEQLELRPVLYNYLSEDVTVSVHVSPVEGLCLAGGGLLAQQVSVPAGSARPVAFSVVPTAAASMPLKVVARGSFDIGDAVSKILQIEKEGAIHREEIVYNLDPLNNLGRSLEIPGSSDPNVIPDGDFSSFVRVTASEPLETLGSEGALSPGGVASLLKLPTGCAEQTMVLLAPTLTASRYLDRTEQWSKLPPETKDHAVDLIQKGHMRIQQFRKKDGSFGAWLDRDSSTWLTAFVLKILSLAQEQIGDSPEKLQETAGWLLGQQLDDGSFHDPCPVIQRGMQGGLVGTDETVALTAFVVIALHHGLAVFQDENSQQLKKRVEASIMKANSFLGQKASAGLLGAHASAITAYALTLTKASEDLRNVAHNSLMAMAEETGENLYWGLAIGSQDNVVSSTAAPRNPSEPVPQAPALWIETTAYGLLHLLLREGKGEMADKAATWLTHQGSFQGGFRSTQDTVVALDALSAYWIASHTTEEKALNVTLSSMGRNGYKSHLLQLNNHQVKGLEEELKFSLGSTINVKVGGNSKGTLKILRTYNVLDMKNTTCQDLRIEVTITGYVEYTREANEDYEYDYDMPAADDPSVHSQPVTPLQLFEGRRSRRRREAPKAADEQESRVQYTVCIWRNGNLGLSGMAIADITLLSGFQALRADLEKLTSLSDRYVSHFETDGPHVLLYFDSVPTTRECVGFGALQEVAVGLVQPASAVLYDYYSPDHKCSVFYAGPTKSKLLSTLCSADVCQCAEGKCPRQRRSLERGVEDKDGYRMKFACYYPRVEYGFQVKVLREDSRSAFRLFETKITQVLHFTKDAKASIGQTRNFLVRASCRLRLEPSKEYLIMGMDGVTSDLKGDPQYLLDSNSWIEEMPSERLCRSTRQRAACGQLNDFLQEYRSQGCQV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0001848 (complement binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0002252 (immune effector process), GO:0002253 (activation of immune response), GO:0048584 (positive regulation of response to stimulus), GO:0006955 (immune response), GO:0002684 (positive regulation of immune system process), GO:0050778 (positive regulation of immune response), GO:0050776 (regulation of immune response), GO:0006956 (complement activation), GO:0006959 (humoral immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)