Protein: Sodium channel protein (A0A8M3B7Z1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR000048: IQ motif, EF-hand binding site (binding_site) [1829-1851]
- IPR024583: Voltage-gated Na+ ion channel, cytoplasmic domain (domain) [517-602]
- IPR005821: Ion transport domain (domain) [128-1711]
- IPR010526: Sodium ion transport-associated domain (domain) [943-1123]
- IPR043203: Voltage-gated cation channel calcium and sodium (family) [45-1913]
- IPR058542: SCN5A-like, C-terminal IQ motif (domain) [1823-1854]
- IPR001696: Voltage gated sodium channel, alpha subunit (family) [1683-1731]
- IPR044564: Voltage-gated sodium channel alpha subunit, inactivation gate (domain) [1391-1443]
- IPR027359: Voltage-dependent channel domain superfamily (homologous_superfamily) [122-1568]
Sequence:
MATMLLPAGPDGLRPFTRESLAAIEQRISEERARNTKDYKADPGDVEEPKPRADLEVGKVLPRIFGEIPAGLVGVPLEDIDPFYFRNQKTFIVLNKGKAIFRFSATSALYIFSPFHCIRRISIRILVHSLFSLFIMCTILTNCCFMAMSDPPLWTKYLEYTFTGIYTFESLIKILARGFCTECFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMILTVFCLSVFALIGLQLFMGILRQKCVRSIGHCVNSTYPGNGSFVCNNKTWLSVKDFLTNEDNFYKIEGSKDALICGYSSDAGKCPDGFDCLKTSRNPNYGYTSFDTFGWAFLGLFRLMTQDYWESLYHQTLRSAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATIAEAWAKEREFQLAMEHLRKEQRALAKQRRKEAEMALAADFCPSPFSRKDSIKCRTRTRSHRTLSEEIEDSFLPKFEPLDEKPAHPLLATLSSHPLSTRRGSQMSIFTFRPRNSSEADFADDEHSVADYGRSRAGSMATPWHKHRTGSIRSHSSQVFTPTLANGRLNISLEQNGITGIGLHTPTTGPKFSMEKVKEGTEPECQNEQVKLTVDVQEEVLPPRRKRGLSSVSFFSDAMDELEEARQKCPPCWYEFAQKYLIWTCSPAWLRVKEGLKVMVMDPFLDLAITICIVLNTLFMALEHYPMTDEFNSMLSIGNLVFTGIFTAEMVLKIFALDPYYYFQQGWNIFDGIIVCLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYQDCVCKISYDCTLPRWHMKDFFHSFLIVFRVLCGEWIETMWDCMEVAGQPLCILVFMLVMVIGNLVVLNLFLALLLSSFSSDNLSAPDEDGEMNNLQIAIARIHCGFSWLLNGIKDLFSGNLTRHRRKSKEAQVTLNHTECNGGLGSLEKYVFPETEDSYMTNPNLTICVPIAPGESDVEFLEEEEEEEDTESSEDEEEKQEVISLSEGSTVDLRKPGEDEEEYSEMADDGMDPEECFPEFCMQRCKCCNINTTQGLGQMWWRLRKTCYQIVEHSWFETFIIFMILLSSGALAFEDIYIEQRKVVKVVLEYADKVFSYIFVLEMFLKWIAYGFKKYFTNYWCWLDFLIVDVSLISLVANSLGYSDFGAIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGKCVNRTGFIHNASIVNNKTECLSMNDTQFYWTKVKVNFDNVGLGYLSLLQVATFKGWMEIMYAAVDSRGVEDQPIKEINLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKRMIGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPMNILQGFFFDLVSKQAFDITIMMLIILNMITMMVETDEQSARMETILNNINLAFIVIFTTECLIKIFALRCYFFTISWNIFDFVVVILSIVGKCTTFQSGIVLADIIEKYFVSPTLFRVIRLARIGRVLRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMANFAYVKKQGGIDDMFNFETFGNSMICLFQITTSAGWNNLLDPILNNSPEECSSSFANTGTNTKGNCGHPSVGITFFVSYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFEMFYEVWEKFDVEATHFIEYAKLSNFADSLSEPLRIAKPNKIKLIHMDLPMVNGDRIHCLDILFAFTKRVLGETGEMDALKQQMEEKFMVTNPSKISHEPITTTLRRKQEEISATLIQRAYRAHLIRRQMKQASYLYRHINQETPWSEEDSAPEQEGLIASMIKENYGPEKMVGTLCYASSPPSYEAVTRSPRDHFKLLISDSRSNEPHKSEETYEETFL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005272 (sodium channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005248 (voltage-gated sodium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0051239 (regulation of multicellular organismal process), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0048731 (system development), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0009799 (specification of symmetry), GO:0009790 (embryo development), GO:0035239 (tube morphogenesis), GO:0009855 (determination of bilateral symmetry), GO:0060562 (epithelial tube morphogenesis), GO:0048568 (embryonic organ development), GO:0003007 (heart morphogenesis), GO:0060972 (left/right pattern formation), GO:0035050 (embryonic heart tube development), GO:0048562 (embryonic organ morphogenesis), GO:0072359 (circulatory system development), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:1903522 (regulation of blood circulation), GO:0007507 (heart development), GO:0061371 (determination of heart left/right asymmetry), GO:0007368 (determination of left/right symmetry), GO:0008016 (regulation of heart contraction), GO:0001947 (heart looping)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0001518 (voltage-gated sodium channel complex), GO:0034703 (cation channel complex), GO:0034706 (sodium channel complex)