Protein: RAD21 homolog (S. pombe) (A0A8I6ANZ0)
Organism: Rattus norvegicus (Rat)
Function: May promote apoptosis
Subcellular location: Chromosome, centromere. Cytoplasm, cytosol. Nucleus
InterPro domains:
- IPR023093: ScpA-like, C-terminal (homologous_superfamily) [561-629]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [562-632]
- IPR006909: Rad21/Rec8-like protein, C-terminal, eukaryotic (domain) [579-632]
- IPR049589: NXP-1, middle HEAT-repeat binding domain (domain) [316-395]
- IPR006910: Rad21/Rec8-like protein, N-terminal (domain) [1-103]
- IPR039781: Rad21/Rec8-like protein (family) [1-632]
Sequence:
MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDDDMLVSTSASNLLLEPEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSETGVMLPEQPAHDDMDEDDNGSLGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREEQQPQPQQQQAQRDVIDEPIIEEPSRLQDSVMEASRTNIEESAMPPPPPQGVKRKAGQVDPEPAIPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEEEEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0048523 (negative regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0051129 (negative regulation of cellular component organization), GO:0045786 (negative regulation of cell cycle), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0010948 (negative regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0010639 (negative regulation of organelle organization), GO:0051983 (regulation of chromosome segregation), GO:0007346 (regulation of mitotic cell cycle), GO:0007088 (regulation of mitotic nuclear division), GO:0045839 (negative regulation of mitotic nuclear division), GO:1901987 (regulation of cell cycle phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:1905819 (negative regulation of chromosome separation), GO:0006325 (chromatin organization), GO:0033043 (regulation of organelle organization), GO:1905818 (regulation of chromosome separation), GO:0051985 (negative regulation of chromosome segregation), GO:1901988 (negative regulation of cell cycle phase transition), GO:1902099 (regulation of metaphase/anaphase transition of cell cycle), GO:1902750 (negative regulation of cell cycle G2/M phase transition), GO:0033048 (negative regulation of mitotic sister chromatid segregation), GO:0051783 (regulation of nuclear division), GO:1902749 (regulation of cell cycle G2/M phase transition), GO:0051784 (negative regulation of nuclear division), GO:0010965 (regulation of mitotic sister chromatid separation), GO:0045841 (negative regulation of mitotic metaphase/anaphase transition), GO:0033047 (regulation of mitotic sister chromatid segregation), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0033045 (regulation of sister chromatid segregation), GO:1902100 (negative regulation of metaphase/anaphase transition of cell cycle), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:2000816 (negative regulation of mitotic sister chromatid separation), GO:0033046 (negative regulation of sister chromatid segregation), GO:2001251 (negative regulation of chromosome organization), GO:0033044 (regulation of chromosome organization), GO:0010389 (regulation of G2/M transition of mitotic cell cycle), GO:0030071 (regulation of mitotic metaphase/anaphase transition), GO:0010972 (negative regulation of G2/M transition of mitotic cell cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)