Protein: Hedgehog protein (A6KCC4)
Organism: Rattus norvegicus (Rat)
Function: [Protein hedgehog N-product]: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development
Subcellular location: Endoplasmic reticulum membrane. Membrane; Lipid-anchor
InterPro domains:
- IPR003587: Hint domain N-terminal (domain) [197-304]
- IPR050387: Hedgehog Signaling (family) [7-392]
- IPR001657: Hedgehog protein (family) [6-395]
- IPR006141: Intein N-terminal splicing region (ptm) [199-275]
- IPR000320: Hedgehog, N-terminal signalling domain (domain) [23-185]
- IPR001767: Hedgehog protein, Hint domain (domain) [187-394]
- IPR003586: Hint domain C-terminal (domain) [305-349]
- IPR009045: Peptidase M74/Hedgehog-like, zinc-binding domain superfamily (homologous_superfamily) [20-194]
- IPR036844: Hint domain superfamily (homologous_superfamily) [199-345]
Sequence:
MALPASLLPLCCLALLALSVQSCGPGRGPVGRRRYVRKQLVPLLYKQFVPSMPERTLGASGPAEGRVTRGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHIHVSVKADNSLAVRAGGCFPGNATVRLRSGERKGLRELHRGDWVLAADAAGRVVPTPVLLFLDRDLQRRASFVAVETERPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELMG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007272 (ensheathment of neurons), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0008366 (axon ensheathment), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048515 (spermatid differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0007283 (spermatogenesis), GO:0007224 (smoothened signaling pathway), GO:0007399 (nervous system development), GO:0032355 (response to estradiol), GO:0042552 (myelination), GO:0033993 (response to lipid), GO:0014070 (response to organic cyclic compound), GO:0007286 (spermatid development), GO:0043627 (response to estrogen), GO:0048232 (male gamete generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031984 (organelle subcompartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0098827 (endoplasmic reticulum subcompartment), GO:0031985 (Golgi cisterna), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane), GO:0005795 (Golgi stack), GO:0005634 (nucleus)