Protein: Receptor protein-tyrosine kinase (A0A8M9P541)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR050122: Receptor Tyrosine Kinase (family) [55-969]
- IPR036941: Receptor L-domain superfamily (homologous_superfamily) [23-519]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [709-962]
- IPR044912: Epidermal growth factor receptor, juxtamembrane domain (homologous_superfamily) [638-694]
- IPR000719: Protein kinase domain (domain) [707-964]
- IPR006212: Furin-like repeat (repeat) [219-592]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [176-627]
- IPR032778: Growth factor receptor domain 4 (domain) [495-627]
- IPR000494: Receptor L-domain (domain) [54-467]
- IPR006211: Furin-like cysteine-rich domain (domain) [182-328]
- IPR016245: Tyrosine protein kinase, EGF/ERB/XmrK receptor (family) [2-1426]
- IPR017441: Protein kinase, ATP binding site (binding_site) [713-740]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [701-980]
Sequence:
MGQQVLALCALLFLCVPQPVTSQTQEVCTGTKNALSSTGTPEQHYNNLKERYTGCEIVMGNLEITQMENDLDFSFLGSIREVTGYILIAMNQFRKLPLNQLRVIRGSSLYDKEWALSVFHNFDTHTGLEDLGLTNLTEILEGGVQIVHNRNLSYAPLINWQDIVRDGDARIQIQDNGGRGSCNPACGEFCWGPSNDQCQKLTKTVCALQCLGHCFGTNPNECCHPECAGGCTGPRDTDCFACRHVNYSGSCVPHCPWPVVYNQQTFQVEPNADAMYQFGSICVPKCPGHFVVDGSACVSSCPPGKTEIEKNQIKQCETCIGLCPKVCEGTGANHRQTVDSSNIDSFINCTKIQGSLHFLILGIKGDVYNNIPPLEPEKLKVFNTVREITGILNIQSWPDELHDLSVFSSLTTIQGRSLYKPFSLLVMKIPSLTSLGLRSLREISDGSVYITQNMNLCYHHTINWTQIFPRNQLQRRRNDIKENKQKIQCEEEGHVCDPLCSDAGCWGPGPEQCLSCRNYSRLGTCVSHCNLYSGEPREFAASNKECLACHSECLLQNGKQTCLGKGADQCVACSNLMDGPHCVSSCPNGVNGEKGQTIFKYSTAAGHCELCHFNCTRGCTGPALRDCVDPDRNVNSSQIAGIAVAVFAGITVLLALFVLGMLYHRGLAIRRKRALRRYLESGESMEPLDPGEKGTKVHARILKPQELRKGKLLGYGVFGTVNKGFWIPEGDSLKIPVAIKTIQNRSSRQTFTEITDHMLSMGSLDHPYIVRLIGICPGASLQLITQLSPHGSLLQHLRQHKDSLDPQRLLNWCVQIAKGMYYLEEHCMAHRNLAARNILLKSDYIVQISDFGVADLLYPDDKKYVYSEHKTPIKWMALESILFGRYTHQSDVWSYGVTVWEMMSYGAEPYASMHPHDVPGLLEKGERLAQPQICTIDVYMVMVKCWMIDENVRPTFKELASEFTRMARDPPRYLVVRPAQNGSGAEESQRYVKSSHLEVGLEEEDDDEDEGLQVGFATPPLQLSPTRSHSRVRIASYKSTSEHTAPIGYLPMTPGPGDEPRQLRAQRRKIGSVRTESECSEGRGTIVDIEAIEITSQTGSLRRGRSRMDSAYISGGVSVASDPFSPGLEGVDEDHYGYVLPTERDFRSAVPHGRTSRNSKSTPKTDATQEYELMNKQTNKLSSSPTDSTDHLKPASLVSAHICSSLPQKKEMDSAQTQDEILPQKRETDSIQSQENNLPQKSETDSTQTQESEKDASFQPDNLESAENCLIGSETLNDGGQSEDEEQLPRLAMVEYEYMDIRTDEHQQNVAGKRTTNGPNEVEREAIYQNISQPLRFHENPDSAGNTMQRRGEYVDMEASGRSGCEVGDYQNVPVKGRPVVGEESQNTGLRSYIKVCAGVEPQNTSFDNPDYWHSRLFHKQDTVCT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0071840 (cellular component organization or biogenesis), GO:0007272 (ensheathment of neurons), GO:0003008 (system process), GO:0008037 (cell recognition), GO:0048066 (developmental pigmentation), GO:0021675 (nerve development), GO:0008038 (neuron recognition), GO:0008366 (axon ensheathment), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0000902 (cell morphogenesis), GO:0009888 (tissue development), GO:0050931 (pigment cell differentiation), GO:0016043 (cellular component organization), GO:0050877 (nervous system process), GO:0042246 (tissue regeneration), GO:0031099 (regeneration), GO:0001964 (startle response), GO:0016477 (cell migration), GO:0048882 (lateral line development), GO:0048864 (stem cell development), GO:0030030 (cell projection organization), GO:0007413 (axonal fasciculation), GO:0042552 (myelination), GO:0048880 (sensory system development), GO:0021545 (cranial nerve development), GO:0021782 (glial cell development), GO:0030318 (melanocyte differentiation), GO:0010001 (glial cell differentiation), GO:0060485 (mesenchyme development), GO:0001667 (ameboidal-type cell migration), GO:0048666 (neuron development), GO:0031101 (fin regeneration), GO:0022008 (neurogenesis), GO:0050905 (neuromuscular process), GO:0048863 (stem cell differentiation), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0007422 (peripheral nervous system development), GO:0008347 (glial cell migration), GO:0048762 (mesenchymal cell differentiation), GO:0030182 (neuron differentiation), GO:0014033 (neural crest cell differentiation), GO:0048925 (lateral line system development), GO:0120036 (plasma membrane bounded cell projection organization), GO:0014044 (Schwann cell development), GO:0090497 (mesenchymal cell migration), GO:0042063 (gliogenesis), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0014037 (Schwann cell differentiation), GO:0014032 (neural crest cell development), GO:0048892 (lateral line nerve development), GO:0048881 (mechanosensory lateral line system development), GO:0048915 (posterior lateral line system development), GO:0061564 (axon development), GO:0106030 (neuron projection fasciculation), GO:0001755 (neural crest cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)