Protein: Zinc finger protein 418 (D3ZVT0)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional repressor (By similarity). May play a role as regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway
Subcellular location: Nucleus
InterPro domains:
- IPR036051: Krueppel-associated box domain superfamily (homologous_superfamily) [41-95]
- IPR013087: Zinc finger C2H2-type (domain) [287-678]
- IPR001909: Krueppel-associated box (domain) [47-123]
- IPR050758: Zinc finger protein, C2H2-type (family) [43-494]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [282-682]
Sequence:
MAAVKHLAQIPRCTETGMICTQGCVTIEDVTVYFSQEEWKLLDEAQRLLYLDVMLENFTLISSLVYRYEAEAEEKTCAQTPQVRTPKQGQLRQKPHPSDICITVLKDILHLNDLPGQKPYLTEVCTKPQDHKHHRAKNWLKRDVDSLVKSCIFHVAGNPFICSKIGEKFPAIWNLLQPKDIPNGEKQNKIKRGKAFHRDKNNSESDEYKKSSSPQHRLHEYPGVCSAKGGFESNSCEQDLNKYSPAPFRMDQTENRPYECHVCGKWFGQKATLRIHQRRHTGEKPYKCGECGKSFCQSSNLSEHCRVHSGERPFECLECGKAFGCHSSLLRHQRTHTGEWPYECSDCGRLFRQIVSLITHQRTHTTEKPYECGQCEKSFSHKATLTVHQRVHTGEKPYHCEACGKSFSQSANLIKHSKIHTGEKPYECGECGLCFRQRATLMKHQRTHTSERPYECRECGKFFKQYFYLIEHRRIHTTTEFYECEQCGKSYTQKATLIRHQRVHTGESPYKCEECGKAFEYKSRLKRHQRTHTGERPYECAKCGKFFRESYNLAEHQKIHTKAKPYHCDQCGKCFSRRADLVKHQRVHTGERPYTCGECGKTFSRTTNLVQHRRIHTGERPYECDQCGKSFSQVSTLTRHQLLHTGEKPYKCSK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0045926 (negative regulation of growth), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0003008 (system process), GO:0040008 (regulation of growth), GO:0009892 (negative regulation of metabolic process), GO:0003012 (muscle system process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:2000026 (regulation of multicellular organismal development), GO:0045596 (negative regulation of cell differentiation), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0048640 (negative regulation of developmental growth), GO:0046621 (negative regulation of organ growth), GO:0001558 (regulation of cell growth), GO:0044057 (regulation of system process), GO:0030308 (negative regulation of cell growth), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0046620 (regulation of organ growth), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0043502 (regulation of muscle adaptation), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0014741 (negative regulation of muscle hypertrophy), GO:0031324 (negative regulation of cellular metabolic process), GO:0048638 (regulation of developmental growth), GO:0055022 (negative regulation of cardiac muscle tissue growth), GO:0055021 (regulation of cardiac muscle tissue growth), GO:0060420 (regulation of heart growth), GO:0014896 (muscle hypertrophy), GO:0061117 (negative regulation of heart growth), GO:0051246 (regulation of protein metabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0010611 (regulation of cardiac muscle hypertrophy), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0061050 (regulation of cell growth involved in cardiac muscle cell development), GO:0051148 (negative regulation of muscle cell differentiation), GO:0090257 (regulation of muscle system process), GO:0010614 (negative regulation of cardiac muscle hypertrophy), GO:0051147 (regulation of muscle cell differentiation), GO:0051174 (regulation of phosphorus metabolic process), GO:0051154 (negative regulation of striated muscle cell differentiation), GO:0014897 (striated muscle hypertrophy), GO:0014743 (regulation of muscle hypertrophy), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:0051153 (regulation of striated muscle cell differentiation), GO:0045936 (negative regulation of phosphate metabolic process), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0003300 (cardiac muscle hypertrophy), GO:0042326 (negative regulation of phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)