Protein: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (Q91YT0)
Organism: Mus musculus (Mouse)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains FMN, which is the initial electron acceptor as well as one iron-sulfur cluster
Subcellular location: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
InterPro domains:
- IPR011538: NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain (domain) [81-249]
- IPR011537: NADH ubiquinone oxidoreductase, F subunit (family) [41-449]
- IPR019575: NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain (domain) [364-448]
- IPR037225: NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily (homologous_superfamily) [37-273]
- IPR054765: SLBB domain (domain) [274-356]
- IPR050837: Complex I 51 kDa subunit (family) [22-462]
- IPR037207: NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily (homologous_superfamily) [360-457]
- IPR001949: NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site (conserved_site) [200-388]
Sequence:
MLAARHFLGGLVPVRVSVRFSSGTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGALRRGDWYKTKEILLKGPDWILGEMKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIMRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSDYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNISGHVNHPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVKGDARPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEDRMQRFAQQHRAWQAAS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0022900 (electron transport chain), GO:0045333 (cellular respiration), GO:0022904 (respiratory electron transport chain), GO:0019646 (aerobic electron transport chain), GO:0009060 (aerobic respiration), GO:0042773 (ATP synthesis coupled electron transport), GO:0006119 (oxidative phosphorylation), GO:0006120 (mitochondrial electron transport, NADH to ubiquinone), GO:0042775 (mitochondrial ATP synthesis coupled electron transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0016020 (membrane), GO:0070469 (respirasome), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0031975 (envelope), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005746 (mitochondrial respirasome), GO:0098803 (respiratory chain complex), GO:0043229 (intracellular organelle), GO:0098800 (inner mitochondrial membrane protein complex), GO:0005739 (mitochondrion), GO:1902495 (transmembrane transporter complex), GO:1990204 (oxidoreductase complex), GO:0030964 (NADH dehydrogenase complex), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0045271 (respiratory chain complex I), GO:0043231 (intracellular membrane-bounded organelle), GO:0005747 (mitochondrial respiratory chain complex I), GO:0019866 (organelle inner membrane), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)