lokahq/bioreason-rl huggingface dataset:
Protein: Serine/arginine repetitive matrix protein 4 isoform X2 (A0A8M3B9F2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
Sequence:
MAGVLLGEKQLFEKFWKGTFKAVAMPRPESIIVASITARRAVTKLETPVGPKDDEEKVKAKDLVTKTHEKNGHIKRRGRKRHSHRRARSVSFDADLSPRPVPKTKKKKKKSQRKRRRHRSPSCSPSPVRKKKKKKSSKKRKRHRSASRKGRHSGSSSRRKRKEDKKHKKRSRSHSHRRHRHRKAEIRSSSCMENRSEDCEKSGFRDGGRSSDVHGGDACRSAVKLTNKISSKCCCHFSESTEEVLIGFSITFWG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0043229 (intracellular organelle), GO:0005681 (spliceosomal complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005684 (U2-type spliceosomal complex), GO:0005634 (nucleus)
Protein: Vasohibin-1 (F1QXP0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR028131: Tubulinyl-Tyr carboxypeptidase (family) [53-369]
Sequence:
ERDEEPEDEGEDLRDGGVPFIINRGGLPVNEETWEQMWRHVARIHPDGEQLARRIRGTRDLPKIPVPSVPTFQPSISIAHRLEAIQKYIRDLQYNHTGTQFFEIKKSRPLTALMDIAKEMTRESLPIKCLEAVILGIYLTNSMPSVERFPLSFKTQFSGSHFRHIVLGVHSGGRFGALGISRRQDLMYKSLQYKTLSDLLLDFQEAYRGHWHTLCRVRIGHYVSHDPHSVEQIEWKHSVLDVDKLTREELRKELERHTRDMRLKIGKAAPPSPSKDRKKDVGSPLRNPGSPMRKNSQSDRRPSVEKRPASAGPAADVNGYQIRV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0008092 (cytoskeletal protein binding), GO:0008237 (metallopeptidase activity), GO:0008238 (exopeptidase activity), GO:0003779 (actin binding), GO:0004180 (carboxypeptidase activity), GO:0008235 (metalloexopeptidase activity), GO:0004181 (metallocarboxypeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051239 (regulation of multicellular organismal process), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0002040 (sprouting angiogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0060840 (artery development), GO:0048844 (artery morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: IQ motif and SEC7 domain-containing protein 1 isoform X8 (A0A8M9PVJ2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR033742: IQ motif and SEC7 domain-containing protein, PH domain (domain) [626-761]
- IPR035999: Sec7 domain superfamily (homologous_superfamily) [405-595]
- IPR023394: Sec7, C-terminal domain superfamily (homologous_superfamily) [481-608]
- IPR000904: Sec7 domain (domain) [399-594]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [623-762]
Sequence:
MLERKYGGRFITRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSLTDDGSKLGALVQSERGEMVPANMKSPAVQSDFTDAITELEDVFSRQVKSLAESIDDALNCRSLHGDEGQSEATRGHPDLEQEVTYQVKPSHGSEHRKRDEMTASYSDVTLYIDEEELSPPLPLSQSVDRPSSTESDLRLRSLNSSQDYWSLAHKDEKADTDTSCRSTPSLECQEQRLRIDHLPLLTIEPPSDSSVELSDRSDRSSLKRQNAYDRGIASQQGSPKHIPSHALPPRGPAREDEAPRHRPRQLESHLAINGTANRQSKSESDFSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKETRNSWDSPAFSNDIIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPREMLVGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGVRLTSALPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKYRIESELEKQKGVVRPSISQSSGLKKETGNGNLSRTSLDDSYAMGEGLKRSALSSSLRDLSDAGKRGRRSSAGSLDSNMEGSIISSPHIRRRATSSRDCPSRQQSIPNSSSLLGSLFGTKRGKSPSLPSQSSHPSHPTLISHTPHPSNLHHTARDGVTVTETQAQMHPHHAQFCHMQNPPPYHHHHHYHPPAHIQHPPHQYHPPPGPSSSHSHSHSQHGHGPHPSHSSHPSHSQHAPHHHSQPPAPPPAASSTKPKHSGISTVV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001945 (lymph vessel development), GO:0036303 (lymph vessel morphogenesis), GO:0001946 (lymphangiogenesis), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098794 (postsynapse), GO:0030054 (cell junction), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0099572 (postsynaptic specialization), GO:0043228 (non-membrane-bounded organelle), GO:0098685 (Schaffer collateral - CA1 synapse), GO:0098984 (neuron to neuron synapse), GO:0099091 (postsynaptic specialization, intracellular component), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0032279 (asymmetric synapse), GO:0099092 (postsynaptic density, intracellular component)
Protein: Caspase recruitment domain-containing protein 8 isoform X8 (A0A8M9QJG0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR011029: Death-like domain superfamily (homologous_superfamily) [377-465]
- IPR033516: CARD8/ASC/NALP1, CARD domain (domain) [378-459]
- IPR051249: NLRP Inflammasome (family) [102-459]
- IPR001315: CARD domain (domain) [378-462]
- IPR025307: FIIND domain (domain) [85-370]
Sequence:
MSDSEDEGECTSDSDDERGMRISLSDSDDESTSKRRFRHPRSLSMGTRSRTVKRHRFHRLQASKKTETVLEHVDGAESSSGQTPSDDAEIFTPELIQEDDKYKDKNTYRFVCPHAGQFQCSLTSLVFVMDGEGELLYRVVSWDPRLLDGLGQMQPAGPLYDVKCFNGSISKLHLPHCEIFSEGDNMDGLAVAHFTGGNMEIVQPITVTETHVMIDIRDLSLFGLLWMKIFSHPISGQVLLFLRTLPVEEEEEEEKILNVHLLPGNVPVSEVVHSHQDKKYIETTSKCHLFLEREYSLRCQPENCEVQPKSEIFEHNNFGPNFHPSFQVFLSVDVKKVGLTILDKAEDCKEVWSRPRVSLKAPSQGVEPPEHRMISGSEFVDALRGKLIQRVSSVMAIADSLRSKHMITDELYSELHNADTNQRKMRCLFMALDSGGASVKAEFYRLLKKNEPHLVEELESGHSKSFRRQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0044092 (negative regulation of molecular function), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0032088 (negative regulation of NF-kappaB transcription factor activity), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Heat shock 70 kDa protein isoform X1 (B0UXR9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR018181: Heat shock protein 70, conserved site (conserved_site) [11-350]
- IPR043129: ATPase, nucleotide binding domain (homologous_superfamily) [7-384]
- IPR013126: Heat shock protein 70 family (family) [8-614]
- IPR029048: Heat shock protein 70kD, C-terminal domain superfamily (homologous_superfamily) [540-620]
- IPR029047: Heat shock protein 70kD, peptide-binding domain superfamily (homologous_superfamily) [387-545]
Sequence:
MSSPKGIAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPNNTVFDAKRLIGRRFDDPVVQSDMKHWSFKVVSDGGKPKVAVEHKGENKTFNPEEISSMVLVKMKEIAEAYLGQKVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGKSSERNVLIFDLGGGTFDVSILTIEDGIFEVKATAGDTHLGGEDFDNRMVNHFVEEFKRKHKKDISQNKRALRRLRTACERAKRTLSSSSQASIEIDSLYEGIDFYTSITRARFEELCSDLFRGTLDPVEKALRDAKMDKAQIHDIVLVGGSTRIPKIQKLLQDFFNGRELNKSINPDEAVAYGAAVQAAILMGDTSGNVQDLLLLDVAPLSLGIETAGGVMTALIKRNTTIPTKQTQTFSTYSDNQPGVLIQVFEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAADKSTGKQNKITITNDKGRLSKEEIERMVQEADNYKAEDDLQREKISAKNSLESYAFNMKNSVEDDNLKGKISEEDKKRVIEKCNEAVSWLENNQLADKEEYEHQLKELEKVCNPVISKLYQGGMPAGGCGAQARGASGASAQGPTIEEVD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0010035 (response to inorganic substance), GO:0009887 (animal organ morphogenesis), GO:0048513 (animal organ development), GO:0009410 (response to xenobiotic stimulus), GO:0048731 (system development), GO:0090596 (sensory organ morphogenesis), GO:0010038 (response to metal ion), GO:0007423 (sensory organ development), GO:0048880 (sensory system development), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0046686 (response to cadmium ion), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Glucagon receptor isoform X2 (A0A8M6YWT8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR050332: G-protein coupled receptor 2 (family) [10-432]
- IPR017981: GPCR, family 2-like, 7TM (domain) [127-389]
- IPR036445: GPCR family 2, extracellular hormone receptor domain superfamily (homologous_superfamily) [13-135]
- IPR017983: GPCR, family 2, secretin-like, conserved site (conserved_site) [54-392]
- IPR000832: GPCR, family 2, secretin-like (family) [126-388]
- IPR001749: GPCR, family 2, gastric inhibitory polypeptide receptor (family) [39-286]
- IPR001879: GPCR, family 2, extracellular hormone receptor domain (domain) [38-120]
Sequence:
MSQVVLLLTLLSFNSCIQVSSAVSLKTMMERWMMYRDECFRNMSREAPMTGVVCNRTFDRYACWPDALPNTTVSVACPWYLPWHKEVRHGLVHVECDADGQYSKQKDASECLSRDNIQHYGRILRQFRTMYTVGYSLSLGALVLALSILVAFRKLHCMRNNIHMNLFASFILRASSILIKDALSERPDTFPVGQDITTELETAVGCRVAVVMMQYSILANSYWLLVEGIYLHSLLVVTVLTERNYLSIYLSIGWGAPLIFVLPWVIVKYLYENEECWEQNNHMEYWWIIRSPILLAVLINFFIFIHIIKILVSKLRAHQMRYSDYKFRLAKSTLTLIPLLGIHSVLFSFVTDESTSHGALPLRLTKLFIDLFFNSFQGLLVAILYCFVNKEVQSEILKKWRRWKLGRDIEEEYRHTYSQSLQIQKSGSIMVHPTNLPRLPDIATTTSRLGSPEEKQMLVSSSQNGMGIGQGCLQFTSTQQDGSTCSSITEDMVVVDRERYCRVAQGNAESNL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0042562 (hormone binding), GO:0017046 (peptide hormone binding), GO:0042277 (peptide binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0062012 (regulation of small molecule metabolic process), GO:0010675 (regulation of cellular carbohydrate metabolic process), GO:0010906 (regulation of glucose metabolic process), GO:0006109 (regulation of carbohydrate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Membrane protein MLC1 isoform X1 (A0A8M9PQ91)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR033280: Membrane protein MLC1 (family) [5-395]
Sequence:
MDLRMQREEASAQEVFSYAQMSTLERNSGVGTLSRHLERERLERDGYTVDVRASDLQLDQPGPLHPCFSYRVWLYSVVVGSSLLIASAFSLYMGNVFPAAMDYLRCTAGSSIPAAVVSFAIAKNRQVAVSDFQLVYVSSFAVTTTCLVWFGCKLAISPSAININFNLLLLIVLEVLTASTVILSARSVDNCCSHSKPVSEGPMIVTQTSFPTRLFKAFAVIELIVGIAAVFGGIIALNLGALLPEPYLSVTFFWILAACFPSAIASHVVAENPSKSLVEMLIAINSVTSPLLFSASAFLSSSVISFIEIFLHEVALAKQSYDILLLVLMLLLLVPAVLTLATIIQCASYKSQVRMGANEWDTLRKKHCEQLASNGTLRDFDKEKAWKAVVVQMAQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0033036 (macromolecule localization), GO:0051641 (cellular localization), GO:0070727 (cellular macromolecule localization), GO:0008104 (protein localization), GO:0034394 (protein localization to cell surface)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005911 (cell-cell junction)
Protein: Estrogen-related receptor gamma isoform X7 (A0A8M9PNM9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
Sequence:
MSNKDRHIESSCPSYIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPTLYGPTGALGPSGTGAKRYEDCSSTITEDSQIKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGLATGNIEYSCPATNECEITKRRRKSCQACRFMKCLTVGMMREGVRLDRVRGGRQKYKRRIDAENSPYLNPQLALPPKKPFPFGCLADNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVNIGWAKHIPGFSTLSLADQMSLLQSAWMEILILRVVYRSLSFEDKLVYAEDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHVEDPRRAGKLLMTLPLLRQTSTKAVQHFYSIKQDGKVPMHKLFLELLEAKV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0009791 (post-embryonic development), GO:0048316 (seed development), GO:0045165 (cell fate commitment), GO:0090376 (seed trichome differentiation), GO:0048608 (reproductive structure development), GO:0090377 (seed trichome initiation), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0090558 (plant epidermis development), GO:0061458 (reproductive system development), GO:0010026 (trichome differentiation), GO:0010154 (fruit development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Stress-activated protein kinase JNK (A0A8M6Z3P4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity
Subcellular location: Cytoplasm
InterPro domains:
- IPR003527: Mitogen-activated protein (MAP) kinase, conserved site (conserved_site) [61-163]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [147-159]
- IPR000719: Protein kinase domain (domain) [26-321]
- IPR050117: Mitogen-activated protein (MAP) kinase (family) [24-347]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [14-343]
- IPR008351: Mitogen-activated protein (MAP) kinase, JNK (family) [76-335]
Sequence:
MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAGYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPSPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDCLFPADSEHNKLKASQARDLLSKMLIIDPAKRISVDEALQHPYINVWYDPAEVEAARNQQISMPPPQIYDKQLDEREHSIDEWKELIYKEVMNFEERTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLETSAGPLGCCR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0048483 (autonomic nervous system development), GO:0007399 (nervous system development), GO:0061008 (hepaticobiliary system development), GO:0048484 (enteric nervous system development), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)