Protein: Thyrotropin receptor (A0A8M9QNC1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism
Subcellular location: Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi- pass membrane protein. Lateral cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
Sequence:
MGTLRYRCCNRILCSLIINISCDFRVLNYISVKTISSRSFDGLKGVRRIEIAQSSSVETIESEAFNNLPNVSEISIQNTRNLVHIQQRAFNQLPKLRYLSISNTGISVFPDLTSIFSLEAHFILDICDNLNLRSVPSNAFTGMTSEYATMNLFNNGFQEIESHAFNGTKIDKLVLKNSRDLRVIHEDAFKGALGPTVLDVSSTALETLPSHGMESVLMLTARSAFALKKLPPLKSLKSLREAQLTFPSHCCALINWDNSRDGSVNSALRNRSSYCGDNSSPADLSAISSDDPLESDVIGSSSVEDTFGSIDFHYPDLDLCQQRQALQCSPEADAFNPCEDIAGFSFLRVAIWFINILAIAGNLVVLLVLFTSRCKLTVPRFLMCHLAFADLCIGIYLLMIATVDLRTRGHYSHHAIEWQTGAGCGIAGFLSVFGGELSIYTLSTITVERWHTITHALRLERRLGLSQASLIMTIGWLLCLAMALLPLIGVSSYSKVSMCLPMDIETPLSQAYVILLLLFNVGAFLVICGCYVCIYSAVRNPEFPGRAADAKIAKRMAVLIFTDFLCMAPISFFAISAAFKVPLITVTNSKILLVLFYPINSCANPFLYAIFTRAFRKDACILLSSMGCCQSKANLYRMKTYCSENINRSKSSSGSNANSKGPRAVMWMSSFPQLTPRPHIQRV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0016500 (protein-hormone receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0048511 (rhythmic process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0019953 (sexual reproduction), GO:0023056 (positive regulation of signaling), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0022602 (ovulation cycle process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0042698 (ovulation cycle), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048609 (multicellular organismal reproductive process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0046660 (female sex differentiation), GO:0007276 (gamete generation), GO:0009967 (positive regulation of signal transduction), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0007283 (spermatogenesis), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0010647 (positive regulation of cell communication), GO:0001541 (ovarian follicle development), GO:0007548 (sex differentiation), GO:0061458 (reproductive system development), GO:0071310 (cellular response to organic substance), GO:0008406 (gonad development), GO:0032870 (cellular response to hormone stimulus), GO:0046545 (development of primary female sexual characteristics), GO:0034698 (response to gonadotropin), GO:1902533 (positive regulation of intracellular signal transduction), GO:0048232 (male gamete generation), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling), GO:0008585 (female gonad development), GO:0010738 (regulation of protein kinase A signaling), GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling), GO:0043410 (positive regulation of MAPK cascade), GO:0032354 (response to follicle-stimulating hormone), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0071372 (cellular response to follicle-stimulating hormone stimulus), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)