Protein: NADH-ubiquinone oxidoreductase chain 5 (P18932)
Organism: Drosophila melanogaster (Fruit fly)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
InterPro domains:
- IPR001750: NADH:quinone oxidoreductase/Mrp antiporter, transmembrane domain (domain) [102-383]
- IPR003945: NADH-quinone oxidoreductase, chain 5-like (family) [9-568]
- IPR010934: NADH dehydrogenase subunit 5, C-terminal (domain) [389-569]
- IPR001516: NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal (domain) [37-85]
Sequence:
MCSISFVNLISMSLSCFLLSLYFLLNDMIYFIEWELVSLNSMSIVMTFLFDWMSLLFMSFVLMISSLVIFYSKEYMMNDNHINRFIMLVLMFVLSMMLLIISPNLISILLGWDGLGLVSYCLVIYFQNIKSYNAGMLTALSNRIGDVALLLSIAWMLNYGSWNYIFYLEIMQNEFEMLMIGSLVMLAAMTKSAQIPFSSWLPAAMAAPTPVSALVHSSTLVTAGVYLLIRFNIILSTSWLGQLMLLLSGLTMFMAGLGANFEFDLKKIIALSTLSQLGLMMSILSMGFLKLAMFHLLTHALFKALLFMCAGAIIHNMNNSQDIRLMGGLSIHMPLTSACFNVSNLALCGMPFLAGFYSKDMILEIVSISNVNMFSFFLYYFSTGLTVSYSFRLVYYSMTGDLNCGSLNMLNDESWIMLRGMMGLLIMSIIGGSMLNWLIFPFPYMICLPIYMKLLTLFVCIVGGLFGYLISLSNLFFLNKSLFMYNLSTFLGSMWFMPYISTYGMIFYPLNYGQLVVKSFDQGWSEYFGGQHLYQKLSMYSKTLFLMHNNSLKIYLLLFVFWILILLILLFL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0022804 (active transmembrane transporter activity), GO:0008137 (NADH dehydrogenase (ubiquinone) activity), GO:0015399 (primary active transmembrane transporter activity), GO:0003954 (NADH dehydrogenase activity), GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor), GO:0050136 (NADH dehydrogenase (quinone) activity), GO:0015453 (oxidoreduction-driven active transmembrane transporter activity), GO:0003955 (NAD(P)H dehydrogenase (quinone) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0009259 (ribonucleotide metabolic process), GO:0009141 (nucleoside triphosphate metabolic process), GO:0045333 (cellular respiration), GO:0009117 (nucleotide metabolic process), GO:0046390 (ribose phosphate biosynthetic process), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0009060 (aerobic respiration), GO:0009165 (nucleotide biosynthetic process), GO:0009144 (purine nucleoside triphosphate metabolic process), GO:0006164 (purine nucleotide biosynthetic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009260 (ribonucleotide biosynthetic process), GO:0009199 (ribonucleoside triphosphate metabolic process), GO:0009142 (nucleoside triphosphate biosynthetic process), GO:0009201 (ribonucleoside triphosphate biosynthetic process), GO:0009152 (purine ribonucleotide biosynthetic process), GO:0046034 (ATP metabolic process), GO:0009145 (purine nucleoside triphosphate biosynthetic process), GO:0009205 (purine ribonucleoside triphosphate metabolic process), GO:0006119 (oxidative phosphorylation), GO:0006754 (ATP biosynthetic process), GO:0042776 (proton motive force-driven mitochondrial ATP synthesis), GO:0009206 (purine ribonucleoside triphosphate biosynthetic process), GO:0015986 (proton motive force-driven ATP synthesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0031975 (envelope), GO:0016020 (membrane), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0070469 (respirasome), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:1902495 (transmembrane transporter complex), GO:0005746 (mitochondrial respirasome), GO:0098803 (respiratory chain complex), GO:0043229 (intracellular organelle), GO:1990204 (oxidoreductase complex), GO:0098800 (inner mitochondrial membrane protein complex), GO:0030964 (NADH dehydrogenase complex), GO:0043227 (membrane-bounded organelle), GO:0005747 (mitochondrial respiratory chain complex I), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0045271 (respiratory chain complex I), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)