Protein: Suppressor of tumorigenicity 14 protein homolog (A0A8M1N8U6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site
Subcellular location: Membrane; Single- pass type II membrane protein
InterPro domains:
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [598-829]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [579-833]
- IPR017051: Peptidase S1A, matripase (family) [7-834]
- IPR002172: Low-density lipoprotein (LDL) receptor class A repeat (repeat) [438-587]
- IPR001254: Serine proteases, trypsin domain (domain) [596-833]
- IPR000082: SEA domain (domain) [75-196]
- IPR033116: Serine proteases, trypsin family, serine active site (active_site) [779-790]
- IPR036055: LDL receptor-like superfamily (homologous_superfamily) [438-593]
- IPR023415: Low-density lipoprotein (LDL) receptor class A, conserved site (conserved_site) [522-544]
- IPR018114: Serine proteases, trypsin family, histidine active site (active_site) [634-639]
- IPR036364: SEA domain superfamily (homologous_superfamily) [67-185]
- IPR035914: Spermadhesin, CUB domain superfamily (homologous_superfamily) [210-431]
- IPR000859: CUB domain (domain) [204-433]
Sequence:
MDPMDGGMRYTPVSTDKDWDQAVTFLPASDHKKMEKKKGPGKIGIIVGLVILAAVLALIIGLVVWHFHFRNDLKLQKIYTGSFRITNEAFVDAYENPQSPEFQNLADKVSTQLKLMYSESSQLSKYYVTSRVQAFSEGSVIAYYESEFAVPAAHEAAVDQAVSNLSEKYSSGKARKVSEQQGSLVLDSVVSSALDKRLISKARSSTRYNKHTSRFVEDIIFSPGFPDSPYPSNTFVQWQLRGDPDHVLKLTFDTFNLEQNCSNDFLRVYDSLVALDKFIMAEKCGYYSPSDPLSFISSRNVMLVTLVTNEEGAYPGFRARVSQIQAVTCGGRMIGNSGIFTSPNFPDYYPPNITCQWYIEVPAGKFIKLKFPKIMVSTGSECHGDFVEVVGQSKLCGQQLNTIVTVNSNTATVRFVSDSSNVDRGFSATFEDYSPSDPCQDLFLCNNKRCVKPSMRCDGWNDCGDTSDEQNCQCDAKMIQCKNGLCKPMFWRCDGVDDCGDSTDELNCGCRADQFKCKNDKCISEKQKCDGKDDCNDGSDEEGCARTDSCLVSTFLCGNSKCITKPNPECDGQDDCGDNSDESNCNCGTKAYKKSRIVGGQDAFEGEFPWQVSLHIKNIAHVCGGSIINERWIVTAAHCVQDDVKIKYSQPGTWEVFLGLHSQKDKLTATKRLLKQVIPHPYYNAYTYDNDIALMEMESPVTFSDTIRPVCLPTATDTFPAGTSVFISGWGATREGGSGATVLQKAEVRIINSTVCNQLMGGQITSRMTCAGVLSGGVDACQGDSGGPLSFPSGKRMFLAGVVSWGDGCARRNKPGIYSNVPKFRAWIKEKTGV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0071704 (organic substance metabolic process), GO:0008283 (cell population proliferation), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0048729 (tissue morphogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0009888 (tissue development), GO:0043170 (macromolecule metabolic process), GO:0051604 (protein maturation), GO:0002009 (morphogenesis of an epithelium), GO:0006508 (proteolysis), GO:0060429 (epithelium development), GO:0008544 (epidermis development), GO:0010467 (gene expression), GO:0016485 (protein processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)