Protein: Spectrin alpha chain, non-erythrocytic 1 isoform X8 (A0A8M9P3B0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton
InterPro domains:
- IPR002017: Spectrin repeat (repeat) [44-2312]
- IPR035825: Alpha Spectrin, SH3 domain (domain) [971-1023]
- IPR001452: SH3 domain (domain) [967-1026]
- IPR018159: Spectrin/alpha-actinin (repeat) [12-2314]
- IPR011992: EF-hand domain pair (homologous_superfamily) [2310-2447]
- IPR002048: EF-hand domain (domain) [2325-2403]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [967-1030]
- IPR014837: EF-hand, Ca insensitive (domain) [2404-2472]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [2381-2393]
Sequence:
MDISGVKVLETADDIQERRQQVLDRYRRFKELSVVRRQKLEDSYRFQFFRRDADELEKWIQEKLQIASDENYKDPSNLQGKLQKHQAFEAEVQANAEAIIKLDETGNLMISEGHFASETIRTRLEELHRLWDLLLQKTKEKGIRLLQAQKLVQYLRECEDALDWISDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQAAGKLTQENHPEAELILKKQEEVNSAWQRLKGLAQQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALNDKVNTLGGEADRLQQTHPQNATQIHLKRDELITNWEQIQTLATERHARLNDSYMLQRFTADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFKSTDEAGQALLNTGHYASEEVKEKLGILSEEKVSLLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAKDDVATRRDALLSRRNALHERAQFRRAALEDSFHLQQFFRDSDELKSWINEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALQKSGQELVDGKHYASSEVSTRMDEVSSQWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDFGKDLTSVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDADNIRKKQEALVARYEALKEPMAARKQKLSDSLRLQQLFRDVEDEETWIREKEPIASSTNRGKDLIGVQNLLKKHQALQAEISGHEPRIKAVTQKGEAMIDEGHFAGEDVKAKLQELHNRWDGLKGKAAQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSPDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALKEEAQACRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPTQSSSRENLLDEQGSIGLRQDQIENQTAATKEVCSVSMRMKQVEELYGTLLELGEKRKDMLEKSCKKFMLFREANELQQWINEKESALTNEEVGSDLEQVEVLQKKFDDFQKDLKANESRLRDINKVASELESEGLMAEEAPVVQAQDEADSKGASPWKELNNRWRSLQQLAEDRSNMLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPEAVDDIQEKCTELNTAWSSLVGRADQRKEKLGNSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFLAFEQFGQQLLARGHYASPEIKQKLEALDRERADLEKAWVQRRMMLDQCLELQLFNRDCEQAENWMAAREAFLASDDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQSFADQLISADHYAKPEIFKRRSEVLDRWLRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTATDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDTGNALIQRGACAGSEDAVKARLNALDEQWQFLVNKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNGQADSLMASNAFDTSQVKDKRDAVNGRFGKIKSMAAGRRAKLNESHRLHQFFRDLDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELGAHEPAIQSVLETGKKLSDDNTIGQEEIQQRLAQFVEHWRELKDLAAARGQRLEESLEYQQFVANVEEEEAWINEKLNLVGSEDYGDTLAAVQGLLKKHEAFETDFTVHRDRVNDVCSNGDELVKKENHNVENIMAKMKALRGKVLELERAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGITNITALKDQLLAAKHVQSKAIEARHATLMKRWNQLLSNSAARKKKLLEAQDHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIRALRDAHDAFRSSLSSAEADFSQLAELDRQIKSYNVVSNPYTWFTMEALEETWSNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWLQETRTYLLDGIAYRRVIRVYQYEVDDDLSGRSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKEKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFESILDIVDPNRDGNVSLQEYMAFMISRETENVKSSEEIESAFRALSAENKPYVTKEELYQNLTKEQADYCISHMKPYLDSKGREIPSAFDFVEFTRSLFVN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0021700 (developmental maturation), GO:0016043 (cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0048731 (system development), GO:0071695 (anatomical structure maturation), GO:0022008 (neurogenesis), GO:0042551 (neuron maturation), GO:0007399 (nervous system development), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0061024 (membrane organization), GO:0045161 (neuronal ion channel clustering), GO:0048699 (generation of neurons), GO:0045162 (clustering of voltage-gated sodium channels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0033270 (paranode region of axon), GO:0044304 (main axon), GO:0033268 (node of Ranvier), GO:0042995 (cell projection), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0030424 (axon)