Protein: Stimulator of interferon genes protein 5 (A0A2B4SJZ1)
Organism: Stylophora pistillata (Smooth cauliflower coral)
Function: Facilitator of innate immune signaling that acts as a sensor of second messenger signals produced by cyclic GMP-AMP synthase-like receptors (cGLRs) and promotes the production of type I interferon . Innate immune response is triggered in response to nucleotides from viruses and bacteria delivered to the cytoplasm . Acts by binding cyclic dinucleotides: recognizes and binds 2'-3' linked cGAMP (2'-3'-cGAMP), a second messengers produced by cGLRs in response to nucleotides in the cytosol, such as double- stranded RNA (dsRNA). Upon binding to 2'-3'-cGAMP, oligomerizes and promotes the recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon (By similarity)
InterPro domains:
- IPR029158: Stimulator of interferon genes protein (family) [86-279]
- IPR038623: Stimulator of interferon genes protein, C-terminal domain superfamily (homologous_superfamily) [144-295]
- IPR055432: STING, ligand-binding domain (domain) [106-282]
Sequence:
MMSNDSQSEKRTAKWTGSGTPIAEGEESSSPSAHQTRQKATAADDDDDQQITDLEQELAELDLEEQRKAKKKRIASLQRQIEEKRNKLATVEISDLNEKENKNVVNVADGLAWSYYSGYLKLVLPRLEQRISESEKFRHKITDKKLYILLPKSCFTCDDIEHADSRVKWAGNLPESKINRGGIKERSYKHAVHEIVMPPFPDGTGEKYHFIVEYATPLMTLYDMSKFADAQLTDPERDHQVLLFMQKLTELLEKSKDCKGQYDCRGKYELVSFDEEEDKIADILIARHNNANKVGEESEELSIPVQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0097367 (carbohydrate derivative binding), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0030551 (cyclic nucleotide binding), GO:0032555 (purine ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0019001 (guanyl nucleotide binding), GO:0032561 (guanyl ribonucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009894 (regulation of catabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0010506 (regulation of autophagy), GO:0031331 (positive regulation of cellular catabolic process), GO:0010508 (positive regulation of autophagy), GO:0031329 (regulation of cellular catabolic process), GO:0016239 (positive regulation of macroautophagy), GO:0016241 (regulation of macroautophagy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0032993 (protein-DNA complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)