lokahq/bioreason-rl huggingface dataset:
Protein: Beta-defensin 13 (A0A7G6KN55)
Organism: Crocodylus porosus (Saltwater crocodile) (Estuarine crocodile)
Function: Exhibits antimicrobial activity against fungi . Antimicrobial activity in a pH-dependent manner against the yeast C.albicans; activity is salt tolerant and retains antifungal activity in NaCl concentrations of 100mM. Permeabilizes C.albicans cell membranes via targeting plasma membrane phospholipid phosphatidic acid
Subcellular location: Secreted
InterPro domains:
- IPR001855: Beta-defensin-like domain (domain) [28-61]
Sequence:
MRLLYLLFAAVMLLFLQAVPANGSYYSTLQCRNNHGHCRRLCFHGEQWIGNCNGRHQHCCK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0005543 (phospholipid binding), GO:0005126 (cytokine receptor binding), GO:0001664 (G protein-coupled receptor binding), GO:0042379 (chemokine receptor binding), GO:0048020 (CCR chemokine receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (O62215)
Organism: Caenorhabditis elegans
Function: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
InterPro domains:
- IPR034804: Fumarate reductase/succinate dehydrogenase, transmembrane subunit (homologous_superfamily) [19-145]
- IPR007992: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, CybS (family) [6-144]
Sequence:
MAASLRHMAHFQKALLVARSAPRISTIVRATSTLNDGASKVPDHSMHFKLERLWAVGMLPILPASYFIHGPVMDAVLTVALTLHIHWGIHGVVYDYARPYVIGEAAAKAAHVGVYLITGLLLGALLHFNTNDVGITKAFELVFSL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0000104 (succinate dehydrogenase activity), GO:0016635 (oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0022900 (electron transport chain), GO:0022904 (respiratory electron transport chain), GO:0045333 (cellular respiration), GO:0019646 (aerobic electron transport chain), GO:0009060 (aerobic respiration), GO:0042773 (ATP synthesis coupled electron transport), GO:0006123 (mitochondrial electron transport, cytochrome c to oxygen), GO:0042775 (mitochondrial ATP synthesis coupled electron transport), GO:0006119 (oxidative phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Chromosomal replication initiator protein DnaA (Q04N63)
Organism: Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Subcellular location: Cytoplasm
InterPro domains:
- IPR010921: Trp repressor/replication initiator (homologous_superfamily) [352-453]
- IPR001957: Chromosomal replication control, initiator DnaA (family) [4-453]
- IPR003593: AAA+ ATPase domain (domain) [147-279]
- IPR013317: Chromosomal replication initiator protein DnaA, ATPAse domain (domain) [115-275]
- IPR018312: Chromosomal replication control, initiator DnaA, conserved site (conserved_site) [412-431]
- IPR013159: Chromosomal replication initiator, DnaA C-terminal (domain) [362-452]
- IPR020591: Chromosomal replication control, initiator DnaA-like (family) [148-431]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [113-327]
Sequence:
MKEKQFWNRILEFAQERLTRSMYDFYAIQAELIKVEENVATIFLPRSEMEMVWEKQLKDIIVVAGFEIYDAEITPHYIFTKPQDTTSSQVEEATNLTLYDYSPKLVSIPYSDTGLKEKYTFDNFIQGDGNVWAVSAALAVSEDLALTYNPLFIYGGPGLGKTHLLNAIGNEILKNIPNARVKYIPAESFINDFLDHLRLGEMEKFKKTYRSLDLLLIDDIQSLSGKKVATQEEFFNTFNALHDKQKQIVLTSDRSPKHLEGLEERLVTRFSWGLTQTITPPDFETRIAILQSKTEHLGYNFQSDTLEYLAGQFDSNVRDLEGAINDITLIARVKKIKDITIDIAAEAIRARKQDVSQMLVIPIDKIQTEVGNFYGVSIKEMKGSRRLQNIVLARQVAMYLSRELTDNSLPKIGKEFGGKDHTTVIHAHAKIKSLIDQDDNLRLEIESIKKKIK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006260 (DNA replication), GO:0006270 (DNA replication initiation), GO:0006261 (DNA-templated DNA replication)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0032993 (protein-DNA complex)
Protein: Aspartyl aminopeptidase (Q8I2J3)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Aminopeptidase which specifically catalyzes the removal of glutamic acid or aspartic acid residues from the N-terminus of peptides . May play a role in the final step of host hemoglobin catabolism, by cleaving hemoglobin- derived oligopeptides in the cytoplasm (Probable)
Subcellular location: Cytoplasm
InterPro domains:
- IPR023358: Peptidase M18, domain 2 (homologous_superfamily) [90-218]
- IPR001948: Peptidase M18 (family) [2-568]
Sequence:
MDKKAREYAQDALKFIQRSGSNFLACKNLKERLENNGFINLSEGETWNLNKNEGYVLCKENRNICGFFVGKNFNIDTGSILISIGHIDSCALKISPNNNVIKKKIHQINVECYGSGLWHTWFDRSLGLSGQVLYKKGNKLVEKLIQINKSVLFLPSLAIHLQNRTRYDFSVKINYENHIKPIISTTLFNQLNKCKRNNVHHDTILTTDTKFSHKENSQNKRDDQMCHSFNDKDVSNHNLDKNTIEHLTNQQNEEKNKHTKDNPNSKDIVEHINTDNSYPLLYLLSKELNCKEEDILDFELCLMDTQEPCFTGVYEEFIEGARFDNLLGSFCVFEGFIELVNSIKNHTSNENTNHTNNITNDINDNIHNNLYISIGYDHEEIGSLSEVGARSYCTKNFIDRIISSVFKKEIHEKNLSVQEIYGNLVNRSFILNVDMAHCSHPNYPETVQDNHQLFFHEGIAIKYNTNKNYVTSPLHASLIKRTFELYYNKYKQQIKYQNFMVKNDTPCGSTVGSMVAANLSMPGIDIGIPQLAMHSIREIAAVHDVFFLIKGVFAFYTYYNQVLSTCVHDK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008237 (metallopeptidase activity), GO:0008238 (exopeptidase activity), GO:0004177 (aminopeptidase activity), GO:0008235 (metalloexopeptidase activity), GO:0070006 (metalloaminopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: 3',5'-bisphosphate nucleotidase (C4M4T9)
Organism: Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM)
Function: Phosphatase that converts 3'-phosphoadenosine 5'-phosphate (PAP) to AMP. Is also able to hydrolyze inositol 1,4- bisphosphate but with less efficiency
Subcellular location: Cytoplasm
InterPro domains:
- IPR020583: Inositol monophosphatase, metal-binding site (binding_site) [115-128]
- IPR051090: Inositol Monophosphatase Superfamily (family) [2-314]
- IPR000760: Inositol monophosphatase-like (family) [10-311]
- IPR020550: Inositol monophosphatase, conserved site (conserved_site) [256-270]
Sequence:
MSFDKELALALEIVQVSCKITTSVAEHTLTDQTQIKNDKSPVTVGDYSVQAYVNKKIHETFPEDQIVAEEDTKTIPEDIFAKVCKHVQIYSDMKDDEIRKSIDLGNSTGGKGRHWVLDPIDGTLGFLRREQYAVCLAFMIDGDIKVGVLGCPNFEGGLIVAAQKGCGAKMFSVNDIKNGKDIHVSTTPKTSDMCFCESVEVSHTDQSRSKTITERLQVTKPPVRMDSQCKYMAIASGRADVYLRLPRNLSYQEKIWDHAAGYLIVKEAGGKVTDIYGNDLDFSLGRTLCNNHGIVASNGILHEETVNVVKDVLSDLK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0008252 (nucleotidase activity), GO:0052745 (inositol phosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006066 (alcohol metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0043647 (inositol phosphate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:1901616 (organic hydroxy compound catabolic process), GO:0046164 (alcohol catabolic process), GO:0046434 (organophosphate catabolic process), GO:0019751 (polyol metabolic process), GO:0046838 (phosphorylated carbohydrate dephosphorylation), GO:0016311 (dephosphorylation), GO:0046174 (polyol catabolic process), GO:0071545 (inositol phosphate catabolic process), GO:0046855 (inositol phosphate dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: D-serine dehydratase (A0A8V1ABE9)
Organism: Gallus gallus (Chicken)
Function: Catalyzes the conversion of D-serine, an allosteric activator of the N-methyl-D-aspartate (NMDA) receptor for L-glutamate, to pyruvate and ammonia
Subcellular location: Cytoplasm. Cell projection, dendrite
InterPro domains:
- IPR051466: D-amino acid metabolism enzyme (family) [5-375]
- IPR029066: PLP-binding barrel (homologous_superfamily) [19-246]
- IPR042208: D-serine dehydratase-like domain superfamily (homologous_superfamily) [10-370]
- IPR026956: D-serine dehydratase-like domain (domain) [262-362]
- IPR001608: Alanine racemase, N-terminal (domain) [17-246]
Sequence:
MWLGALLDTLPTPALTIDRTTAHRNAERMRERCRALGVRLRPHVKTHKTLEGGLLATGGTRRGIAVSTLAEARFFADGGFDDILLAYPVPTARLEECAGLARRLDAFHVLLDRPEALASLRQRPLGHGKRWLVWLKLDCGNGRAGVRPTDPAALELAQAIANDAPEEVTLVGVYAHCGNTYGCSGADTIQAIARTTTNAVLSFVAALRQAGVPCPQASIGSTPSCSHPIPEMSQLTELHPGNYIFYDLQQTQLGSCQPQDVAIRVLTRVIGHYAHRGQLLVDCGWAALSLHGAGAGQGPQGCAAIDGHPELRLVGLTQEHGLLEHAGGQMDFGRFPVGSVLALIPYHACATAAMHPVYYVHEEGKVVALWHPVRGW
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016840 (carbon-nitrogen lyase activity), GO:0016841 (ammonia-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0016054 (organic acid catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0009063 (amino acid catabolic process), GO:0019752 (carboxylic acid metabolic process), GO:1901606 (alpha-amino acid catabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0009069 (serine family amino acid metabolic process), GO:0009071 (serine family amino acid catabolic process), GO:0046416 (D-amino acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Extracellular protease inhibitor 10 (D0NJ41)
Organism: Phytophthora infestans (strain T30-4) (Potato late blight agent)
Function: Secreted effector that interacts with and inhibits the pathogenesis-related P69B subtilisin-like serine protease of host tomato. Inhibition of host proteases by a pathogen extracellular protease inhibitor forms a specific type of defense- counterdefense mechanism between plants and microbial pathogens
Subcellular location: Secreted. Note=Localizes to host apoplast where it targets defense proteases for inhibition
InterPro domains:
- IPR050653: Protease Inhibitors and Growth Factor Antagonists (family) [23-74]
- IPR002350: Kazal domain (domain) [20-208]
- IPR036058: Kazal domain superfamily (homologous_superfamily) [21-205]
Sequence:
MKSAFTLSLALVAVTATISAAADDNCSFGCLDVYKPVCGSNGETYSNSCYLRLASCKSNNGITEAGDGECASTPASSATPSPVTSSTGSTSGTVGCPDMCLDVYDPVSDENGKEYSNQCYMEMAKCKGTGYDDNKRSGNPGISTLDAERKLAFAPGYQGPPCGDMLCPDNYAPVCGSDGETYPNECDLGITSCNHPEQNITMVGEGTLPVTGAATATATATAEVVTRW
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0004866 (endopeptidase inhibitor activity), GO:0004867 (serine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0035821 (modulation of process of another organism), GO:0051701 (biological process involved in interaction with host), GO:0044003 (modulation by symbiont of host process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Cystatin-like cysteine protease inhibitor EPIC2B (D0NBV3)
Organism: Phytophthora infestans (strain T30-4) (Potato late blight agent)
Function: Secreted effector that interacts with and inhibits the pathogenesis-related papain-like cysteine proteases C14, PIP1 and RCR3 of host plants. Inhibition of host proteases by a pathogen extracellular protease inhibitor forms a specific type of defense-counterdefense mechanism between plants and microbial pathogens
Subcellular location: Secreted. Note=Localizes to host apoplast where it targets defense proteases for inhibition
InterPro domains:
- IPR046350: Cystatin superfamily (homologous_superfamily) [30-118]
- IPR000010: Cystatin domain (domain) [30-123]
Sequence:
MSFLRPTLALLAVTALVTTSAQLNGYSKKEVTPEDTELLQKAQSNVSAYNSDVTSRICYLKVDSLETQVVSGENYKFHVSGCSVNSDKELGGCANQNCESSKYDIVIYSQSWTNTLKVTSITPAN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0004866 (endopeptidase inhibitor activity), GO:0004869 (cysteine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0035821 (modulation of process of another organism), GO:0051701 (biological process involved in interaction with host), GO:0044003 (modulation by symbiont of host process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Probable exonuclease V, mitochondrial (Q9Y7L4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity)
Subcellular location: Cytoplasm. Nucleus . Mitochondrion
InterPro domains:
- IPR019190: Exonuclease V (family) [46-402]
Sequence:
MEEYEDFEMEDLSELVSYMDYLETQRLTISQLDYSLSIPPQLLVSREISKLEDEVCEMLKESSLFQLFRKHKGYLNVTDLVLPLWCEVQHEYYLLRRIKKKTPKMERGIKLHQILEYETSPPSERRVLDRTSKEEPWALRLLRQLEGIMLLQKNGITREFPIWGYYKESSIFGIIDEISLNNPSKSNFNSDIRNYFNFKMYDLSFVDNKTRFSSRKPGASQILSSKVQLMYYVHLFLNYFPSLGEKQQSIFRDISPTYSNRLHSQSHWWNMFLSQLSLDGTKDLGPKFLEQSILSIPDIPEDVFAGHNSLNGLYALVFASAKKLHLRLTDDNLTIAYRNDKTGEVVYKDKFSFSNKLLEASYTKAYQFWHNLREPEGVPAEEVYKCRSCEFQKECWWLKKKQYYPLSSP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006281 (DNA repair), GO:0036297 (interstrand cross-link repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: FAD synthase (Q8R123)
Organism: Mus musculus (Mouse)
Function: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme
Subcellular location: Cytoplasm
InterPro domains:
- IPR012183: FAD synthetase with the MoaB/Mog domain (family) [1-491]
- IPR014729: Rossmann-like alpha/beta/alpha sandwich fold (homologous_superfamily) [266-492]
- IPR001453: MoaB/Mog domain (domain) [17-180]
- IPR036425: MoaB/Mog-like domain superfamily (homologous_superfamily) [14-209]
- IPR002500: Phosphoadenosine phosphosulphate reductase domain (domain) [304-459]
- IPR056596: FAD synthase, middle domain (domain) [183-259]
Sequence:
MASRASELPPGSGRSVTAGIIIVGDEILKGHTQDTNTYFLCRTLRSLGVQVCRVSVVPDEVATIASEVNSFSRRFTHVLTAGGIGPTHDDVTFEAVAQAFGEELKPHPELQAAIKTLGGEGWEKLSMVPSSARLHYGTDPRTGHPFRFPLVSVRNVYLFPGIPELLRRVLEGLKGLFQNTAVQFHLKELYVAASEGSIAPILSEAQAHFGRRLSLGSYPDWSSNYFQVKLILDSEEKEPLEECLAYLTARLPQGSLVPYQPDAVEKAGEAVYKLAESGSCLGKKVAGALQTIETALAQYHLSQLCVGFNGGKDCTALLHLFHAAVQRKFPDVPKPLQILYIRSISPFPELEQFLQDTIKRYNLQVLEAEGNMKQALGELQEKHPQLEAVLMGTRRTDPYSCSLSHFSPTDPGWPSFMRINPLLDWTYRNIWEFLRQLFVPYCILYDRGYTSLGSRENTTQNPALKCLSPGGHPVYRPAYLLENEDEERNSRM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016779 (nucleotidyltransferase activity), GO:0070566 (adenylyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0046483 (heterocycle metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006766 (vitamin metabolic process), GO:0006767 (water-soluble vitamin metabolic process), GO:0042726 (flavin-containing compound metabolic process), GO:0006771 (riboflavin metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)