Protein: Protein transport protein SEC23 (A0A8M6Z6P7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side
InterPro domains:
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [134-407]
- IPR006896: Sec23/Sec24, trunk domain (domain) [132-397]
- IPR036180: Gelsolin-like domain superfamily (homologous_superfamily) [628-768]
- IPR006900: Sec23/Sec24, helical domain (domain) [525-623]
- IPR036174: Zinc finger, Sec23/Sec24-type superfamily (homologous_superfamily) [55-129]
- IPR007123: Gelsolin-like domain (domain) [639-725]
- IPR029006: ADF-H/Gelsolin-like domain superfamily (homologous_superfamily) [627-731]
- IPR006895: Zinc finger, Sec23/Sec24-type (domain) [64-104]
- IPR036175: Sec23/Sec24 helical domain superfamily (homologous_superfamily) [525-627]
- IPR012990: Sec23/Sec24, beta-sandwich (domain) [408-511]
- IPR037550: Sec23, C-terminal (domain) [617-737]
- IPR037364: Protein transport protein Sec23 (family) [13-768]
Sequence:
MVVRAVMATYQEFIQQNEDRDGIRCSWNLWPSSRLEATRLVVPVSCLYTPLKERPDLPPVQYEPVLCTRANCKAVLNPLCQVDFRAKIWACNFCFQRNSFPPSYAGISEVNQPAELMPQFSTIEYIVQRGPPTPLIFLYLVDTCLEEEDLQALKESLQMSLSLLPPNALVGLITFGRMIQVHELSCEGIAKSYVFRGTKELAPKQIQEMLGLMKPATSGQQGKPLAPHDAAASCRFLQPVQMVDMNLTDLLGELQRDPWPVPQGKRPLRSTGIALSIAVGLLEGTFPNTGARVMLFTGGPPTQGPGMVVGDELKTPIRSWHDIQKDNARHLKKATKYYEALANRAAVNGHSVDIYACALDQTGLLEMKCLSNLTGGHIVMGDSFNTSLFKQTFQRVFNKDYNGEFRMAFGATLEVKTSRELKVSGAIGPCVSLNTKGPCVSDNEMGVGGTCQWKICSLSPATTLAMYFEVVNQHNAPVPQGGRGVVQFVTQYQHSNTQRRIRVTTIARNWADAQSQIQHIESSFDQEASAVLMARLGVFRAESEEGPDVLRWLDRQLIRLCQKFGQFNKDDPNSFRLSESLSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFVRQDLTQSLIMIQPILYSYSFHGPPEPVLLDSSSILPDRILLMDTFFQLVIYHGETIAQWRKAGYQEMAEYENFKQLLQAPLDDAQEILQTRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNLYAWGQESGAPILTDDVSLQVFMDHLKKLAVSSSA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048871 (multicellular organismal-level homeostasis), GO:0002262 (myeloid cell homeostasis), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0034101 (erythrocyte homeostasis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:1904888 (cranial skeletal system development), GO:0048872 (homeostasis of number of cells), GO:0030097 (hemopoiesis), GO:0051216 (cartilage development), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0030218 (erythrocyte differentiation), GO:0048702 (embryonic neurocranium morphogenesis), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0061448 (connective tissue development), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0030099 (myeloid cell differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0061515 (myeloid cell development), GO:0043009 (chordate embryonic development), GO:0048821 (erythrocyte development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0070971 (endoplasmic reticulum exit site), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)