Protein: Voltage-dependent L-type calcium channel subunit alpha (A0A8M9Q061)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death
Subcellular location: Cell membrane, sarcolemma, T-tubule. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Membrane; Multi- pass membrane protein. Perikaryon. Postsynaptic density membrane
InterPro domains:
Sequence:
MLRGLFSWRRLKHERLEEEVEVRFKGKLVSERELGYTHVRPGGSNYSSPSLAPVPSLNEDEHVGGGGGVLGLAPEHIPTPGAPLSWQAAIDAARQAKLMGTTGAPISTASSTQRKRQHYTKPKKQASTASTRPPRALLCLTLKNPIRRACINIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLCHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGGTSMGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHRTCFFYKDGHKGHIAEEKPAPCAPSSAHGRHCSPPNITQCMMGWEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENDDEGLDDDKPRNLSMPASENESVNTDNAPAGDMEGETCCTRMANRISKSKFSRYSRRWNRLCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHHQQPEWLTNVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKRQNSEKPPLEDEKKEEKIELKSITSDGETPTATKINIDEYTGEDNEEKNPYPVNDFPGEDDEEEPEMPVGPRPRPLSDIQLKEKAVPMPQAKAFFIFSPSNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTSLLQFMFACIGVQLFKGKFFYCTDTSKQTQAECRGAYILYKDGNVGKPEKAQRSWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQSQSFNKAMNILNMLFTGLFTVEMILKLIAFKPRHYFVDAWNTFDALIVVGSVVDIAITEVNGLQNTEDNARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDNSQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACSPNRPCEKGSEINHSSEDCGSHFAIFYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVAKIPPKTALSLQAGLRTLHDMGPEIRRAISGDLTVEEELERAMKETVCAASEDDIFRVKRSGGLFGNHVNYYHQSDGHVSFPQSFTTQRPLHISKSGSPGEAESPSHQKLVDSTFTPSSYSSSGSNANINNANNTAIGHRYPKPTVSTVDGQTGPPLTTIPLPRPTWCFPNKRSCFYDTFMRSDSSDSRLPIIRREEASTDETYDETFLDERDQAMLSMDMLEFQDEESKQLAPMVEAEVGEERRPWQSPRRRAFLCPTALGRRSSFHLECLRKHNRPDVSQKTALPLHLVHHQALAVAGLSPLLRRSHSPTLFTRLCSTPPASPSGRSGGGPCYQPVPSLRLEGSGSYEKLNSSMPSVNCSSWYSDSNGNHSGRAQRPVSLTVPPVTRRDSISLAHGSAGSLVEAVLISEGLGRYAHDPSFIQVAKQEIAEACDMTMEEMENAADNILNANAPPNANGNLLPFIQCRDTGSQESRCSLSLGLSPATGSDGALEAELEESEGAGQRNSPLMEDEDMECVTSL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005262 (calcium channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005245 (voltage-gated calcium channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065008 (regulation of biological quality), GO:0098900 (regulation of action potential), GO:0055085 (transmembrane transport), GO:0032879 (regulation of localization), GO:0060306 (regulation of membrane repolarization), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0051239 (regulation of multicellular organismal process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0051049 (regulation of transport), GO:0035556 (intracellular signal transduction), GO:0007204 (positive regulation of cytosolic calcium ion concentration), GO:0051282 (regulation of sequestering of calcium ion), GO:0098660 (inorganic ion transmembrane transport), GO:0042391 (regulation of membrane potential), GO:0006810 (transport), GO:0044057 (regulation of system process), GO:0034762 (regulation of transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0060402 (calcium ion transport into cytosol), GO:0071702 (organic substance transport), GO:0090257 (regulation of muscle system process), GO:0043269 (regulation of monoatomic ion transport), GO:0006811 (monoatomic ion transport), GO:1903522 (regulation of blood circulation), GO:0051279 (regulation of release of sequestered calcium ion into cytosol), GO:0019932 (second-messenger-mediated signaling), GO:0070588 (calcium ion transmembrane transport), GO:0006937 (regulation of muscle contraction), GO:0010880 (regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum), GO:0008016 (regulation of heart contraction), GO:0006812 (monoatomic cation transport), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0006816 (calcium ion transport), GO:0010959 (regulation of metal ion transport), GO:0019722 (calcium-mediated signaling), GO:0055117 (regulation of cardiac muscle contraction), GO:0030001 (metal ion transport), GO:0051924 (regulation of calcium ion transport), GO:0010882 (regulation of cardiac muscle contraction by calcium ion signaling), GO:1903169 (regulation of calcium ion transmembrane transport), GO:0006942 (regulation of striated muscle contraction), GO:0097553 (calcium ion transmembrane import into cytosol)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0030315 (T-tubule), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0005891 (voltage-gated calcium channel complex), GO:0034702 (ion channel complex), GO:0042383 (sarcolemma), GO:0034703 (cation channel complex), GO:0034704 (calcium channel complex)