Protein: Alpha-galactosidase (A6IVG1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Lysosome
InterPro domains:
- IPR035373: Alpha galactosidase A, C-terminal domain (domain) [327-413]
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [34-325]
- IPR002241: Glycoside hydrolase, family 27 (family) [18-420]
- IPR000111: Glycoside hydrolase family 27/36, conserved site (conserved_site) [87-103]
- IPR013780: Glycosyl hydrolase, all-beta (homologous_superfamily) [327-421]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [34-326]
Sequence:
MAMKLLSGDTPLVCELALRPLALVFWSILGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDACISEQLFMQMAELMVSDGWRDAGYEYLCIDDCWMAPERDSKGRLQADPKRFPSGIKHLANYVHSKGLKLGIYADVGKKTCAGFPGSFGSYDIDAQTFADWGIDLLKFDGCHCDSVVSLANGYKYMSLALNRTGRSIVYSCEWPLYLRPFHKPNYTDIQYYCNHWRNFDDVYDSWESIKSILAWTVTHQKDIVEVAGPGGWNDPDMLVIGNFGLSWDQQVTQMALWAIMAAPLLMSNDLRQISSQAKALLQNEDVIAINQDPLGKQGYCFRKENEIEVWERPLSNLAWAVAVRNLQEIGGPRFYTIQISSLGRGLACNPGCIITQILPEKVHLGFYEWPLTLKTRINPSGTVLLRLER
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0097367 (carbohydrate derivative binding), GO:0016787 (hydrolase activity), GO:0016936 (galactoside binding), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015925 (galactosidase activity), GO:0004557 (alpha-galactosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0044092 (negative regulation of molecular function), GO:0044248 (cellular catabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0043603 (amide metabolic process), GO:1901575 (organic substance catabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0051341 (regulation of oxidoreductase activity), GO:0043086 (negative regulation of catalytic activity), GO:0080164 (regulation of nitric oxide metabolic process), GO:1904406 (negative regulation of nitric oxide metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0006643 (membrane lipid metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0006672 (ceramide metabolic process), GO:1903509 (liposaccharide metabolic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0044242 (cellular lipid catabolic process), GO:0016042 (lipid catabolic process), GO:0006665 (sphingolipid metabolic process), GO:0006677 (glycosylceramide metabolic process), GO:0045019 (negative regulation of nitric oxide biosynthetic process), GO:0030149 (sphingolipid catabolic process), GO:0006664 (glycolipid metabolic process), GO:0045428 (regulation of nitric oxide biosynthetic process), GO:0032768 (regulation of monooxygenase activity), GO:0046514 (ceramide catabolic process), GO:0019377 (glycolipid catabolic process), GO:0051354 (negative regulation of oxidoreductase activity), GO:0006687 (glycosphingolipid metabolic process), GO:0046466 (membrane lipid catabolic process), GO:0050999 (regulation of nitric-oxide synthase activity), GO:0046479 (glycosphingolipid catabolic process), GO:0032769 (negative regulation of monooxygenase activity), GO:0051001 (negative regulation of nitric-oxide synthase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005764 (lysosome)