Protein: Cyclic nucleotide gated channel alpha 3, isoform CRA_c (A6ING6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR032406: Cyclic nucleotide-gated channel, C-terminal leucine zipper domain (domain) [519-589]
- IPR050866: Cyclic nucleotide-gated cation channel (family) [10-593]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [329-526]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [396-534]
- IPR018488: Cyclic nucleotide-binding, conserved site (conserved_site) [430-491]
- IPR005821: Ion transport domain (domain) [90-330]
- IPR000595: Cyclic nucleotide-binding domain (domain) [403-527]
Sequence:
MHQMETSTMVQDNRVSRFIISIRAWAARHLHHEDPTPDSFLDRFHGAELKEVSSQERNAQPNPGGQEPPEGGKGRKKDPIVVDPSSNIYYRWLTAIALPVFYNWCLLVCRACFDELQSEHLTLWLVLDYSADALYVVDMLVRARTGFLEQGLMVRDTKRLWKHYTKTLHFKLDILSLIPTDLAYLKLGMNYPELRFNRLLRFSRLFEFFDRTETRTNYPNVFRIGNLVLYTLIIIHWNACIYFAISKFIGFGTDSWVYPNTSKPEYGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPAVFSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMETLTEYPDAKRALEEKGRQILMKDNLIDDDLVTARADARNIEEKVEYLESSLDGLQTRFARLLAEYSASQMKLKQRLSQLESQMTRRGHGFSPDRENSEDASKAD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0022857 (transmembrane transporter activity), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0030551 (cyclic nucleotide binding), GO:0032555 (purine ribonucleotide binding), GO:0030553 (cGMP binding), GO:0017076 (purine nucleotide binding), GO:0005261 (monoatomic cation channel activity), GO:0019001 (guanyl nucleotide binding), GO:0022839 (monoatomic ion gated channel activity), GO:0032561 (guanyl ribonucleotide binding), GO:0022836 (gated channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0005217 (intracellular ligand-gated monoatomic ion channel activity), GO:0043855 (cyclic nucleotide-gated monoatomic ion channel activity), GO:0005221 (intracellular cyclic nucleotide activated monoatomic cation channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0042221 (response to chemical), GO:0055085 (transmembrane transport), GO:0009719 (response to endogenous stimulus), GO:0051234 (establishment of localization), GO:0010035 (response to inorganic substance), GO:0098739 (import across plasma membrane), GO:1901698 (response to nitrogen compound), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:1901700 (response to oxygen-containing compound), GO:0034220 (monoatomic ion transmembrane transport), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0010038 (response to metal ion), GO:0046683 (response to organophosphorus), GO:0051591 (response to cAMP), GO:0098657 (import into cell), GO:0098662 (inorganic cation transmembrane transport), GO:0010243 (response to organonitrogen compound), GO:0033993 (response to lipid), GO:0048545 (response to steroid hormone), GO:0014070 (response to organic cyclic compound), GO:0099587 (inorganic ion import across plasma membrane), GO:0006811 (monoatomic ion transport), GO:0032026 (response to magnesium ion), GO:0098659 (inorganic cation import across plasma membrane), GO:0031960 (response to corticosteroid), GO:0014074 (response to purine-containing compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043204 (perikaryon), GO:0005622 (intracellular anatomical structure), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0044304 (main axon), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0043194 (axon initial segment), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0097386 (glial cell projection), GO:0030425 (dendrite), GO:0030424 (axon)