Protein: Pro-cathepsin H (A0A7I2V673)
Organism: Homo sapiens (Human)
Function: Important for the overall degradation of proteins in lysosomes
Subcellular location: Lysosome
InterPro domains:
- IPR025661: Cysteine peptidase, asparagine active site (active_site) [212-231]
- IPR013128: Peptidase C1A (family) [22-242]
- IPR000169: Cysteine peptidase, cysteine active site (active_site) [51-62]
- IPR039417: Papain-like cysteine endopeptidase (domain) [33-247]
- IPR025660: Cysteine peptidase, histidine active site (active_site) [195-205]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [1-249]
- IPR000668: Peptidase C1A, papain C-terminal (domain) [32-248]
Sequence:
MSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0006955 (immune response), GO:0032879 (regulation of localization), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0002682 (regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0051050 (positive regulation of transport), GO:0009056 (catabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0002253 (activation of immune response), GO:0032963 (collagen metabolic process), GO:0019882 (antigen processing and presentation), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0002764 (immune response-regulating signaling pathway), GO:0032103 (positive regulation of response to external stimulus), GO:0002250 (adaptive immune response), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0019884 (antigen processing and presentation of exogenous antigen), GO:0032409 (regulation of transporter activity), GO:0080134 (regulation of response to stress), GO:0019538 (protein metabolic process), GO:0034762 (regulation of transmembrane transport), GO:0071495 (cellular response to endogenous stimulus), GO:0032101 (regulation of response to external stimulus), GO:0034764 (positive regulation of transmembrane transport), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0002218 (activation of innate immune response), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:0070887 (cellular response to chemical stimulus), GO:0002504 (antigen processing and presentation of peptide or polysaccharide antigen via MHC class II), GO:0002833 (positive regulation of response to biotic stimulus), GO:0032411 (positive regulation of transporter activity), GO:0043270 (positive regulation of monoatomic ion transport), GO:0030574 (collagen catabolic process), GO:0050778 (positive regulation of immune response), GO:0016043 (cellular component organization), GO:0009268 (response to pH), GO:0031349 (positive regulation of defense response), GO:0048002 (antigen processing and presentation of peptide antigen), GO:1901575 (organic substance catabolic process), GO:0031347 (regulation of defense response), GO:0097066 (response to thyroid hormone), GO:0045089 (positive regulation of innate immune response), GO:0002758 (innate immune response-activating signaling pathway), GO:1901565 (organonitrogen compound catabolic process), GO:0045088 (regulation of innate immune response), GO:0006508 (proteolysis), GO:0002478 (antigen processing and presentation of exogenous peptide antigen), GO:0071310 (cellular response to organic substance), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0030163 (protein catabolic process), GO:0051604 (protein maturation), GO:0045229 (external encapsulating structure organization), GO:0034767 (positive regulation of monoatomic ion transmembrane transport), GO:0009057 (macromolecule catabolic process), GO:0032870 (cellular response to hormone stimulus), GO:0043062 (extracellular structure organization), GO:0032414 (positive regulation of ion transmembrane transporter activity), GO:0022898 (regulation of transmembrane transporter activity), GO:0010447 (response to acidic pH), GO:0043269 (regulation of monoatomic ion transport), GO:0002495 (antigen processing and presentation of peptide antigen via MHC class II), GO:0022411 (cellular component disassembly), GO:0010467 (gene expression), GO:0022617 (extracellular matrix disassembly), GO:0097067 (cellular response to thyroid hormone stimulus), GO:0002221 (pattern recognition receptor signaling pathway), GO:0016485 (protein processing), GO:1904064 (positive regulation of cation transmembrane transport), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:0051603 (proteolysis involved in protein catabolic process), GO:2001259 (positive regulation of cation channel activity), GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II), GO:0030198 (extracellular matrix organization), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0071711 (basement membrane organization), GO:2001257 (regulation of cation channel activity), GO:0002224 (toll-like receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle)