Protein: Granulocyte colony-stimulating factor (A6HIT8)
Organism: Rattus norvegicus (Rat)
Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes
Subcellular location: Secreted
InterPro domains:
- IPR030473: Interleukin-6/GCSF/MGF, conserved site (conserved_site) [100-125]
- IPR040117: GCSF/MGF (family) [5-208]
- IPR009079: Four-helical cytokine-like, core (homologous_superfamily) [36-208]
- IPR030474: Interleukin-6/GCSF/MGF (family) [1-207]
Sequence:
MAQLSAQGRMKLMALQLLLWHSALWSGQEAIPLLTVSSLPPSLPLPRSFLLKSLEQVRKIQARNTELLEQLCATYKLCHPEELVLFGHSLGIPKASLSSCSSQALQQTKCLSQLHSGLFLYQGLLQALAGISSELAPTLDMLHLDVDNFATTIWQQMESLGVAPTVQPTQSTMPIFTSAFQRRAGGVLVTSYLQSFLETAHHALHHLA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0008083 (growth factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0048522 (positive regulation of cellular process), GO:0042127 (regulation of cell population proliferation), GO:0043207 (response to external biotic stimulus), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0071216 (cellular response to biotic stimulus), GO:0008284 (positive regulation of cell population proliferation), GO:0097305 (response to alcohol), GO:1901215 (negative regulation of neuron death), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0002237 (response to molecule of bacterial origin), GO:1901214 (regulation of neuron death), GO:1901701 (cellular response to oxygen-containing compound), GO:0071222 (cellular response to lipopolysaccharide), GO:0045471 (response to ethanol), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)