Protein: Mitochondrial fission factor (H7C433)
Organism: Homo sapiens (Human)
Function: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Membrane; Single-pass type IV membrane protein. Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome
InterPro domains:
- IPR039433: Mff-like domain (domain) [1-271]
- IPR008518: Mff/Tango-11 (family) [1-271]
Sequence:
IRAVGRLKRERSMSENAVRQNGQLVRNDSLVTPSPQQARVCPPHMLPEDGANLSSARGILSLIQSSTRRAYQQILDVLDENRRYGISNIDTTIEGTSDDLTVVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFRR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0051050 (positive regulation of transport), GO:0033036 (macromolecule localization), GO:0050793 (regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0032989 (cellular component morphogenesis), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0012501 (programmed cell death), GO:0032388 (positive regulation of intracellular transport), GO:0060341 (regulation of cellular localization), GO:0051649 (establishment of localization in cell), GO:0051130 (positive regulation of cellular component organization), GO:0045184 (establishment of protein localization), GO:0090141 (positive regulation of mitochondrial fission), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0097190 (apoptotic signaling pathway), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0051222 (positive regulation of protein transport), GO:0051128 (regulation of cellular component organization), GO:0006839 (mitochondrial transport), GO:0090316 (positive regulation of intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:1904951 (positive regulation of establishment of protein localization), GO:0072594 (establishment of protein localization to organelle), GO:0070201 (regulation of establishment of protein localization), GO:0032990 (cell part morphogenesis), GO:0071702 (organic substance transport), GO:0032880 (regulation of protein localization), GO:1905477 (positive regulation of protein localization to membrane), GO:0006886 (intracellular protein transport), GO:0051223 (regulation of protein transport), GO:0015031 (protein transport), GO:0006915 (apoptotic process), GO:0033043 (regulation of organelle organization), GO:0008104 (protein localization), GO:0090140 (regulation of mitochondrial fission), GO:0006996 (organelle organization), GO:0010638 (positive regulation of organelle organization), GO:0001836 (release of cytochrome c from mitochondria), GO:0032386 (regulation of intracellular transport), GO:0072655 (establishment of protein localization to mitochondrion), GO:0007005 (mitochondrion organization), GO:0033365 (protein localization to organelle), GO:1905475 (regulation of protein localization to membrane), GO:0070584 (mitochondrion morphogenesis), GO:0010821 (regulation of mitochondrion organization), GO:0007031 (peroxisome organization), GO:0010822 (positive regulation of mitochondrion organization), GO:0033157 (regulation of intracellular protein transport), GO:0008637 (apoptotic mitochondrial changes), GO:0048285 (organelle fission), GO:0090314 (positive regulation of protein targeting to membrane), GO:0090200 (positive regulation of release of cytochrome c from mitochondria), GO:0006605 (protein targeting), GO:0048284 (organelle fusion), GO:0006626 (protein targeting to mitochondrion), GO:0090199 (regulation of release of cytochrome c from mitochondria), GO:0070585 (protein localization to mitochondrion), GO:0016559 (peroxisome fission), GO:0090313 (regulation of protein targeting to membrane), GO:1903533 (regulation of protein targeting), GO:0008053 (mitochondrial fusion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)