Protein: 1-phosphatidylinositol 3-phosphate 5-kinase (B0G126)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Dual specificity kinase part of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5- bisphosphate
Subcellular location: Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein . Late endosome membrane ; Peripheral membrane protein
InterPro domains:
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [984-1197]
- IPR027483: Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily (homologous_superfamily) [2458-2597]
- IPR017455: Zinc finger, FYVE-related (domain) [198-255]
- IPR000306: FYVE zinc finger (domain) [190-256]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [949-1220]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [188-263]
- IPR044769: 1-phosphatidylinositol-3-phosphate 5-kinase, PIPK catalytic domain (domain) [2340-2596]
- IPR027484: Phosphatidylinositol-4-phosphate 5-kinase, N-terminal (homologous_superfamily) [2245-2457]
- IPR002498: Phosphatidylinositol-4-phosphate 4/5-kinase, core (domain) [1667-2597]
- IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [194-257]
Sequence:
MAESFQQLGVGSKSNERSFFSKFFGTDDSQKDFGPLPEIEYSDEQRFNPYPAIYEKKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNGNGNRSNSSLNNSNNNNQVRRTHSPSVSNKSDESNTTNTNTNITTNTNITTNTNTNTNTNSTNNDTSSNVTQQQLLTNLGQSKIISALKTKFQRPLPPVDDKKFWMPDHSSAVCYECSEEFTTFKRRHHCRLCGQIFCWKCSQKTLTDGKGERVRVCNFCYRRYMAPDDLDMEGYHYDPITGTVISLITNNDDGTNLNNGNGLIKLDGSTHNMNVSLGNSGDNSSFVQSPNNNFSQSPTFSQQQQQQQQQQQQQQQQQQQQQQQQTTGVMSGLNPFSNSTLLFGRNNNNNNQQQQQPIIEEDKQYYGDINTSYNNSYFNNNGFNNFNNEHYNNTNFNATSLNLNSQLHSNLLANTNGELFYDNSQHSISNYGNLDHHQQQQQSNSHGSLSATPSNTPSGLISPIVGAPSILDPNKMIFYSDQEGNYDNLDDYETSSSDGSDNDNEDNHLKSSHSSANDLGTSNTVSTGESNSESKLSSSSNDISIHHHHYHHHHHHSHGNLLKSNSLTPLNLNNNNIIINNNNINNNNNNDNGNDDNNNNNNDNNNNTTIEVDPRHSMPSKTSNTSFSMASLPSIFKLPTIGRNNNNNNNSGSGNSQYLSANSNASNSISPPNSARGSSSNPNSMTPTPTLSSSFSNLPNAETSPPSLVKAKQQQQQQQQQQQQPQPVLQPTIHHPLKTSLPMFSTQSPPPPTNQLAQSTSMAPPPSIFSPLGKLQALSHPSSSSNNQQQQQPQIVKPIIIAPNSLFFSDPSIVSLKSHPKTTNKTKFLEKYPLPKKYYESTENIIDTFGFKRTPSTEGNLLSQMLATSKQKEFDEKERLKISNNPQMSVYIQHINNLVSEQLEKNNIDLSWRSIIIDLTKKATDNVKIFVRKGDKMSTNEYIKIKKIPGGNKSECNYVDGVVMTKILTHKKMKDKFINPKILLLSCSVEFQRVENKFLYFDQLLQQEKEYLRILVSKIAERKPDLVLVEKTVSRHAQDFLLDAGISLALNVKPKLLERLGRCLGGEVLPTLDIIYNNNSNNNNSNSIQLQQQQNSNSPASLQNSTTTTNNNNNNNNNSTTLGSCGQFKVITYSEIGLKEKEILGKKTLMYFEKCPVELGATIIIRGEDLAVLKIIKKILKLSIFSMHNAYLELKYLNDQSSTSNLLFVNNNGQNLSCSPQIKFPLPKTYPTIPWKYQFTSQHIPVKKALLTSFYKPHSDFGQQQSVIQWTSDDEVLGIGTSDAFKHCDMKFPIENESIYDHQSIVFSHSIFCNSNQCIPFEIHAIDYYTDNDLTLGEFLSKFCFSLHICNIKECNRPLIEHERTFMNSTTRINICVQKTQTIQDRPTNSSPAQQRNQPVQRAGINVINLCKICNKFSPESPMSEEAWEMSFGKFLELCFFGFLPIKTGISPECSHNNAKDHISYFYYQDLAAIFSYEPLPSLELSLPPKNLKATYTEKQRQSVRAKELEIMNQCANQVYSAIHERLYEIGQENQGDRVQELIPSLVQEKQLICSKIESLLLLPESAHKSNDQIINLTKLLYANFMTWNSQLTGLIDSTSYQRSKRNVQQQQQQQQHQQSQQPQPQILIGGDVYSDSHLHTDSVKKINSKQHSHNTILLQSIQSNQEQQLEQQEEFEINVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTIDNKSENENENKNENKNENENENENKNENKNENENENKKENENQLEIKNENNDSGEEITNNNNNNNNNNNNNNNNNNNNNNNIDNNNNKDENISSTPLLSPSSVLGVSNSGINQAFLNAPNNTYNSVEQDLTLPLNHQSLNFAVGGLVSPGSSSGGLPVGSVPNSSSMPSIHNGGSGNIPSNLVGSASGLSTNYSPNALKDPKKLKIIDTIAGIVSSISQTRILGPTMPYLLLESTDNVALFENEPSTTIAYTLSSSDFKIALNSLLDEEWKRISEIEKQYELQQQQQQDSQDLESSSQQQQQQQQQQQEQQEQPSLPTPSHPLSQSMNFSPSSLLKISSSSLPKDNNNSSENKPNSETNDIVRSRGSVKLSGSPISISPLSNAFEKRKSTSLSSSANNSPISSILEKEKKLKQQSPSLSNSLSGQTIINNNQQQQQQQQPSPIIIDEKDDRNTEKSSIIETDSIIEDLNINQDESNITNEDGGKIGDYESELLYDHHQQGDSENNNNNNNNNNNNNNNNNNNNNNNNNNNTNNNNEQQINNSDTEGDSDSIKSSNSNIYSEKNIKLSKLMVSTQRKEIRSRFKFEKNGYELNIFCSSYYPVQFHALREYMCGDQEFIQSLTRSKIWNAKGGKSGSSWNKTLDDRFILKQVSRIELESFLDFAPLYFEYICKSFLNQIPTALCKILGVFTVRWKDSNGKALKKDLIVMENLFHSKCISKTYDLKGSLRGRLVKNESEVLLDENLLQASFASPICLGEYDKTRVALAVWNDTAFLSSLNVMDYSLLSGIDNQSNQLVVGIIDYMRKFTWDKALEMKVKQSGIMGGGGKVPTVISPKQYKLRFRDAMWLYFTLSPDKFTKVKHLMPYEKKKNNNNNYNYNNFNNNNFNNNNNISNNGNGNINQRQVQQINK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0005543 (phospholipid binding), GO:0043168 (anion binding), GO:0035091 (phosphatidylinositol binding), GO:0005547 (phosphatidylinositol-3,4,5-trisphosphate binding), GO:0005546 (phosphatidylinositol-4,5-bisphosphate binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:1902936 (phosphatidylinositol bisphosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0048878 (chemical homeostasis), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0051641 (cellular localization), GO:0019725 (cellular homeostasis), GO:0009607 (response to biotic stimulus), GO:0006885 (regulation of pH), GO:0099120 (socially cooperative development), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0033036 (macromolecule localization), GO:0051707 (response to other organism), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0043207 (response to external biotic stimulus), GO:0031154 (culmination involved in sorocarp development), GO:0048837 (sorocarp sorus development), GO:0030154 (cell differentiation), GO:0009617 (response to bacterium), GO:0006952 (defense response), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0030641 (regulation of cellular pH), GO:0030587 (sorocarp development), GO:0098542 (defense response to other organism), GO:0055080 (monoatomic cation homeostasis), GO:0051453 (regulation of intracellular pH), GO:0042742 (defense response to bacterium), GO:0008104 (protein localization), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006996 (organelle organization), GO:0044671 (sorocarp spore cell differentiation), GO:0033365 (protein localization to organelle), GO:0050829 (defense response to Gram-negative bacterium), GO:0090382 (phagosome maturation), GO:0051452 (intracellular pH reduction), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0090383 (phagosome acidification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0044352 (pinosome), GO:0097708 (intracellular vesicle), GO:0044354 (macropinosome)