Protein: Neuropathy target esterase isoform X1 (A0A8M2B6R2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane; Single-pass type III membrane protein. Membrane; Single-pass type III membrane protein
InterPro domains:
- IPR002641: Patatin-like phospholipase domain (domain) [938-1104]
- IPR001423: Lysophospholipase patatin, conserved site (conserved_site) [941-973]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [164-711]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [162-711]
- IPR000595: Cyclic nucleotide-binding domain (domain) [170-704]
- IPR056556: Lysophospholipase NTE1-like, P-loop domain (domain) [738-933]
- IPR050301: Neuropathy target esterase (family) [164-1259]
- IPR016035: Acyl transferase/acyl hydrolase/lysophospholipase (homologous_superfamily) [932-1205]
Sequence:
MGQSTSDTESAEPPETDRFGNIKSLVEDQLQTSMVVGIVIGAGVVIVLIAVLIFFVLRRMQLRKLEAQEVPKYRFRKRDKVLFYGRKIMRKVSQSTSSLVGATSSTRPRLKKKQKMLNIAKKILRFKKEVPTLQMKEPPPSVLEADLTEFDVANSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFLQFQQGEYVFRPGQPDSSIYVVQDGKLELCLTGQDGKDGVVKEVYPGDSVHSLLSILDVITGHQRPYKTVSARAAEVSTVLRLPVDAFLSIFEKYPESLVRVVQIIMVRLQRVTVLALHNYLGLTNELFSHEMQPRSSPLSPHPTRSSPVRHSKRFGSLTVPDKHREAAVQNATGGDHGKEGGTIPTLSRTISMPVDIAGMQKSLRSDFDMAYERGRISVSAEDGVPAFTKEQRERKVTVDEVPSGVYLYPEEESGMDIFSSFQGRPNATVFEEAQKEILRLMKIEDPSLLNGRVTFHHAKAGSVLARQGDQDVSLHFVLSGCLHVYQKMIDKQEAVCLFVTQPGEMVGQLAVLTGEPLIFTIKAERDCTFLKISKSEFYEIMREQPSVVLSAAHTVAIRMSAFVRQMDFAIDWMAVEAGRALYRQDDQSDCTYIVLNGRLRSVIRKANGKKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELVKLPEGTLNNIKRRYPQVVTRLIHLLGQKILGNLQQPRGPFSSSALGLPSMASSPDVTNPASNLSTVAVLPVCDEVPINAFNLELSHALSAIGPTLLLTSDIIRERLGASALDSIHEYRLSGWLAQQEDINRIVLYQTDSGMTPWTQRCIRQADCILIVGLGDQEPALGELEQMLENTAVRALKQLILLHREDGPGPSRTVEWLNMRSWCSGHLHLKCPRRVFSRRSPTKLREVYEKVFEKTADRHSDFSRLARVLTGNSIALVLGGGGARGCSHVGVIKAMEDTGIPIDIVGGTSIGSFIGALYAEERSAVRVKQRAREWSKAMNSVFKTVLDLTYPITSMFSGSAFNTSISKVFEDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGNLLMDGGYINNLPADIARTLGTKTVIAIDVGSQDETDLCNYGDCLSGWWLLWKRINPWAEKVKVPDMAEIQSRLAYVSCVRQLELVKKSAYCEYIRPPIDRFKTMDFGKFDEIYDVGYQHGKLVFTEWARGDIIDNMLKDHRSADYNDSKKTDSCPCPSADFTDLAEIVSRIEPVQSYVGADAEESDYATEYEEDGMDTVREEEGEEEEEEGEDPEDQSPGEWGPNGVFPPDEDKTVRQRKNVSRDPNADFSGVSDC
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity), GO:0052689 (carboxylic ester hydrolase activity), GO:0004622 (lysophospholipase activity), GO:0004620 (phospholipase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0071840 (cellular component organization or biogenesis), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0032989 (cellular component morphogenesis), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0000902 (cell morphogenesis), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0009798 (axis specification), GO:0003002 (regionalization), GO:0048468 (cell development), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0009966 (regulation of signal transduction), GO:0016043 (cellular component organization), GO:0090288 (negative regulation of cellular response to growth factor stimulus), GO:0022008 (neurogenesis), GO:0030514 (negative regulation of BMP signaling pathway), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0090101 (negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0032990 (cell part morphogenesis), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0030510 (regulation of BMP signaling pathway), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0009952 (anterior/posterior pattern specification), GO:0048666 (neuron development), GO:0009948 (anterior/posterior axis specification), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)