Protein: Inositol 1,4,5-trisphosphate receptor (A0A8M6Z266)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium
Subcellular location: Endoplasmic reticulum membrane; Multi- pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR014821: Inositol 1,4,5-trisphosphate/ryanodine receptor (domain) [6-230]
- IPR015925: Ryanodine/Inositol 1,4,5-trisphosphate receptor (family) [8-2607]
- IPR000493: Inositol 1,4,5-trisphosphate receptor (family) [51-882]
- IPR035910: RyR/IP3 receptor binding core, RIH domain superfamily (homologous_superfamily) [432-1260]
- IPR000699: RIH domain (domain) [470-1316]
- IPR005821: Ion transport domain (domain) [2270-2474]
- IPR016024: Armadillo-type fold (homologous_superfamily) [1250-1946]
- IPR016093: MIR motif (domain) [114-427]
- IPR036300: Mir domain superfamily (homologous_superfamily) [110-430]
- IPR013662: RyR/IP3R Homology associated domain (domain) [1836-1942]
Sequence:
MSDSASSFLHIGDIVSLYAEGTVNGFISTLGLVDDRCVVEPASGDLENPPKKFRDCLFKVYPMNRYSAQKQFWKAKQAKHEKDKIGDMVLLQKLQHAANLEQKQNDAENKKVHGDVVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDGTGNEGSWLFIQPFWKLRANGDNVVVGDKVILNPVNAGQPLHASSYELPDHSGCKEINSVNSNTSWKISLFMMFSDHKDEVLKGGDVVRLFHAEQEKFLTCDEYKSKLHVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNSLYRFKHLATGNYLAAEENPGYKENSNDIEVDSSRIKRSLGERIKYKLVAVPHGNDIASLFELDPTTLQKTDSFVPRNSYVRFRHLCTNTWIQSTNIPIDIDEERPIRLMLGTCPTKEDKEAFAIVSVPVMEIRDLDFANDASLMLSTVVEKFKYGFLSPNDRRYAIKLLEDVVFFVVDQLNNGQPALEVSMNKPNRERQKLMREQNILKQIFGIIKAPFKERGDDPPLLTLEELSDQKYLLYQYMLRLCYRVLRHSQEDYRKNQEYIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNNVAIPVTQELICKCVLNAKNQDILMKTERRAAKESQHTSEYLEEFGDEDEVWLIWSEKENENHEKSIRQLAQEARQGNVHDENVLTYYRYQLKLFARMCFDRQYLAIDVISKQLDIELISLCMMDETLPFDLRASFCRLMLHAHVDRDPQELVTPIKFARLWTEIPTSISIKDYDSHLDYSRDNKKNKFANTMAFMEEYLNNVLIDDLPFANEEKNKLTYEVVSLARHLIYFGFYSFFELLRLTRTLLGIIDCTPSNASINPLFNDDGSGKNVRRSIHGMGQMMSTMVLNRKPSLFSAPGRTGDSQVGSKDSIDTQDITVMDTKLKILEILQFILSVRLDYRLSFLLSVFKKEFVDVYPMEDADATHHTEHEASINLQHIGEQAEAMFGIGKGNSILEVDDEGGRMFLRVLIHLIMHDYPPLVSGALQLLFKHFSQRQEVLHTFKQVQLLISTQDVDNYKHIKRDLDLLRTMVEKSELWVIKKSSSGGDGKKDKKDKKEPEAVSPEEEADSKKQTTEKSNESYQNVKEILERLNKMCSSGVFKKQQRLLKNMGAHKVMLDLLQISYDRNDTKMLEIIKYTHLFLQKFCTGNLENQALLHKHLNLFLTPRLLEAETMQQIFSNNFQLCSEISESVLHHFIHCLATQGRHIQYLNFLHTIIKAEGKYVKKCQDMIMTELTSAGDDVVVLYTDDTSFNTMVELMTQSREGVKDDSPLRYHISLVELLAACAEGKNVYTEIKCTSLLPLEEMVKVITHEDCITEVKIAYVNFVNHCYVDTEVEMKEIYTSNHIWKLFENFTVDMARVCSNREKRMSDPVLEKYVIQVVLDTVTAFFSSPFSENSTSTEAHHTTVKQLLQSTMRLLDCPWLQPQQKVQVESCIRTLAVTTKSRSIPLPVELEAHVNMMLSHSNSLTLSRSSHSNKSMSRLTRPAAPTNPWDYKNIIEKLQDIINTLEERVMPLVNAELSVLVDVLHQPELLFLEGTDARSRCESGGFISKLIQHTKALMNSDEKLCIKVLRTLQEMLIRELDFDEKGFALRKVLLQNYLYNNKKNIKAELVEHAGGAEGERDWLTVAALQCRLDKEGGTKLFTDLITSTKNEKIFQESIQLAICLLEGGNTEIQNSFYKLMMGDNKSEKFFKVLNDRMKNAQLDIKSTVSVNVGEMSNKAKDDKDLETGGVSSFGQPEPQPEQQEVETEMGPSVTIMKPILRFLQLLCENHNQDLQNFLRIQNNKTNYNLVSETLQFLDIMCGSTTGGLGLLGLYINENNVELITQTLETLTEYCQGPCQENQTCIVSHECNGIDIITALILNDISPLCRYRMELVLQLKDNASKLLLALMESRHDSENAERILFNLRPRELVELIKKAYLQEGECKEGEVSPREVGHNIYILALQLARHNKVLLTLLKPVKKIKEEEEESISSMLNLNKQQEEEKEDPLEHYDRQTAQIEIVREDRSMEQIVFPVHPICEFLTEESKFRVFTTTEQDEQGSKVTNFFEQTSFLHNEMEWQKKLRSMPVLYWFSRRMSLWGTISFNLAVFINLIIALFYPHDSGHSGSIDSSLLLMGFWCFAGLAVLGLLFKRYGFQSLTVAITLRCIYHFGIGPTLLLLGALNLINKIVYLVSFVGNNGTFIMGYKAMVMDVEFLYHVAYVLTSSLGLFVHEFFYSILLFDLIYREETLFNVIKSVTRNGRSILLTAVLAIILVYLFSIVGFLFLRNDFIMEVDHLASPAPGDTESFMSSCSSDGIDCTEETGLLAPAEEDEDNTERACDTLLMCIITVLNHGLRNGGGVGDVLRKPSKNEPLFPARVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEVLKTTCFICGLERDKFDNKTVSFEEHIKLEHNIWNYLYFIVLIREKNKTDYTGPESYVALMIKNKNLDWFPRMQAMSLVVTDGDGEQNEMRNLQDRLSSTMKVVTQLTSQLTELKEQMTEQRKRRQRMGFVDVQSGSNPGMPVPPSPAGGNQVYKA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0008289 (lipid binding), GO:0022857 (transmembrane transporter activity), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0005543 (phospholipid binding), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0035091 (phosphatidylinositol binding), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0005262 (calcium channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0099604 (ligand-gated calcium channel activity), GO:0005217 (intracellular ligand-gated monoatomic ion channel activity), GO:0015278 (calcium-release channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009790 (embryo development), GO:0048731 (system development), GO:0001501 (skeletal system development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0012505 (endomembrane system)