Protein: Tyrosine-protein phosphatase non-receptor type 13 (A6K5V1)
Organism: Rattus norvegicus (Rat)
Function: Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling
Subcellular location: Cytoplasm, cytoskeleton. Nucleus
InterPro domains:
- IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [2135-2448]
- IPR052074: Non-receptor Tyrosine-protein Phosphatases (family) [1-1985]
- IPR012153: Tyrosine-protein phosphatase non-receptor type 13 (family) [1-2454]
- IPR011019: KIND domain (domain) [3-190]
- IPR018980: FERM, C-terminal PH-like domain (domain) [780-869]
- IPR019748: FERM central domain (domain) [658-774]
- IPR000242: Tyrosine-specific protein phosphatase, PTPase domain (domain) [2183-2440]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [2360-2429]
- IPR019749: Band 4.1 domain (domain) [561-774]
- IPR000299: FERM domain (domain) [565-865]
- IPR036034: PDZ superfamily (homologous_superfamily) [1064-1945]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [566-657]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [656-767]
- IPR035963: FERM superfamily, second domain (homologous_superfamily) [658-766]
- IPR018979: FERM, N-terminal (domain) [569-630]
- IPR001478: PDZ domain (domain) [1084-1944]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [2338-2437]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [769-870]
Sequence:
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQEVFRRVSIADPAALGFIISPWSLLLLPSGSVSFTDENVCSQDLRAFTAPEVLQSHSLTSLSDVEKVHIYSLGMTLYWGADHEVPQSQPIKLGDHLNSILLGMCEDVLYARVSVRTVLDACSAHIRNSNCAPSFSYVKQLVKLVLGNISGTDPLSHSSEEKPDRSQAIRDRLRGKGLPIGRSSTSDALDTHKAPLSQQTFLNKGLSKSMGFLSVRDTQEEEDYSKEIPSDNNSRHEDSEPFSSPYQFKTSSPHIDVLSKKKTWASSMDLLCAADRDLSGEIGRYQHCDPETGTGRTSITSRKKEGRYSDGSIALDVFGPQKAEPVIHSRELPASSAVSSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHSDLFSTSSESPSIISSDSDFRQVRKSEASKRFESSSGLPGVDDTVQSRPSRQYETSLEGSLINQEMMLRRQEEEMMQLQARMALRQSRLSLYPGDTIKTSMLDISRDPLREMALETAMTQRKLRNFFGPEFVKTTVEPFASLDLPRSILLQTKKGKSEEQRKKVNIMLLSGQRLELTCDTKTVCRDVFDMVVAHIGLVEHHLFALATLKENEYFFVDPDLKLTKVAPEGWKEEPKRKGKAAVDFTLFFRIKFFMDDVSLIQHSLTCHQYYLQLRKDLLEERIHCDDEASLLLASLALQAEYGDYQPEVHGLSYFRLEHYLPARVMEKLDMSYIKEELPKLHNTYAGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRALVLRFPWRETKKISFSKKKITLQNTSDGIKHAFQTDSSKACQYLLQLCSSQHKFQLQMRARQSNQDAQDLERASFRSLNLQAESVRGFNVGRAISTGSLASSTFNKLAVRPLSVQAEILKRLSCSEWSLYQPLQNSSKEKNDKASWEEKPRGMSKSYHDLSQASLCPHRKQVINMESLPQAFAELVGKPLYPMARSDTESLAGLPQLNNSKSVASLNRSPERRSHESDSSVEDPGQAYVVGMSLPSSGKSSSQVPFKDNDSLHKRWSTVSSPEREITLVNLKKDLKHGLGFQIVGGGKMGRLDLGVFISAVTPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAVDILQNAPEDVTLVISQPKEKPTKVPSTPVHFANGMKNYTKKPSSMQDSAMDPSEDQPWPRGPLRHVPESPFGLSSGLREGSLSSQDSRTESASLSQSHVNGFFTSHLGDRGWQEPQHSSPSPPVTSKITEKTFSDSYRSPARRQGTCDVTELPGCADSDIDDPTYSSSQDRQAPKQEPSSPLKASDKMSFAAFPGPSPEPGDAFEVELAKTDGSLGISVTGGVNTSVRHGGIYVKAVIPNGAAETDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSRERDPASPRCPTPDQDAQSQAPEKMEKQTAHVKDYSFVTEDNTFEVKLFKNSSGLGFSFSREDNLTPELINGSIVRVKKLFPGQPAAESGKINVGDVILKVNGAPLKGLSQQDVISALRGTAPEVSLLLCRPAPGVLPEVNTALLTPLHSPAHAFLNSRKEHSQPSPLSVEQCASSDENGLSGQSKRQCKPPSRRESYSDHSDSGEEESVRAAAKMPNVIPLSAFAPEALRSQGEPASTMFYLPRKIPGKPESESSRLPHPLDVSPGQIRQPPAECAPSDSPGKHLTHLASQLHKEENMTALKNDLGNHLEDSELEVELLITLVKSEKGSLGFTVTKGSQSIGCYVHDVIQDPAKGDGRLRPGDRLVKVNDADVTNMTHTDAVNLLRAAPKTVRLVIGRILELPRMPVFPHLLPDITVTCHGEELGFSLSGGRGSPHGVVYISDINPRSAAAVDCSLQLLDIIHYVNGVSTHGMTLEEANRALDLSLPSVVLKVTRDGCPVVPCSTRSAISALRPLEANGLSSMEPYGQPALTPKKSFSKVNGDGASGAMCPGGKGLSSPRKKSADLMEARESDSRDDDVYDDPQEAEVIQSLLDVVDEEAQNLLNQTKASRRACSPDPLRTNGEASEDGEDTDCDGSPLPEDVPESVNGGGGKACFASLIQASQEEKPVKEEATQESRESTTETTDREDSSKDPLFLTNEELAALPVVRVPPSGKYTGTQLQATIRTLQGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDTTRVPLGDEGGYINASFIRIPVGTQEFVYIACQGPLPTTVGDFWQMVWEQNSTVIAMMTQEVEGEKIKCQRYWPSILGTTTMANERLRLALLRMQQLKGFVVRVMALEDIQTGEVRHISHLNFTAWPDHDTPSHPEDLLTFISYMRHIRRSGPVITHCSAGIGRSGTLICIDVVLGLISQDLEFDISDLVRCMRLQRHGMVQTEGQYVFCYQVVLYVLTHLQAEEQKAQPGLPQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004725 (protein tyrosine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:2000026 (regulation of multicellular organismal development), GO:0051129 (negative regulation of cellular component organization), GO:0051961 (negative regulation of nervous system development), GO:0070887 (cellular response to chemical stimulus), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009636 (response to toxic substance), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0050803 (regulation of synapse structure or activity), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0031324 (negative regulation of cellular metabolic process), GO:0044087 (regulation of cellular component biogenesis), GO:1905809 (negative regulation of synapse organization), GO:0051964 (negative regulation of synapse assembly), GO:0097237 (cellular response to toxic substance), GO:0050807 (regulation of synapse organization), GO:0051246 (regulation of protein metabolic process), GO:1901888 (regulation of cell junction assembly), GO:0051248 (negative regulation of protein metabolic process), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0051960 (regulation of nervous system development), GO:0051174 (regulation of phosphorus metabolic process), GO:1901889 (negative regulation of cell junction assembly), GO:0051963 (regulation of synapse assembly), GO:0019220 (regulation of phosphate metabolic process), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:0045936 (negative regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0042326 (negative regulation of phosphorylation), GO:1904889 (regulation of excitatory synapse assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection)