Protein: [histone H3]-trimethyl-L-lysine(27) demethylase (A0A8M2BFV4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
- IPR019734: Tetratricopeptide repeat (repeat) [95-386]
- IPR051630: Transcriptional Corepressor and Histone Demethylase (family) [32-1428]
- IPR048562: Lysine-specific demethylase 6A/B-like, C-terminal helical domain (domain) [1283-1338]
- IPR046941: Lysine-specific demethylase 6, GATA-like domain superfamily (homologous_superfamily) [1348-1414]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [77-546]
- IPR003347: JmjC domain (domain) [1130-1293]
- IPR048560: Lysine-specific demethylase 6A/B-like, GATA-like (domain) [1355-1415]
Sequence:
MKSCGVSVAAVARAAAAAAAGGDEEKKMAAGKARETEEDFPKLTPQERERLASIDSTLFGFQRLHEDGARTKALLLKAVRCYDVYILKAEGKVEPEVFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFRWAIKAFQEVLYIDPCFSRAKEIHLRLGLMFKVNTDYESSLKHFQLALIDSTPCTLSKAEIQFHIAHVYEIQKKYRIAKEAYESLLQTENLPAQVKATTLQQLGWMHHTVEQLGDKANKNSYAIQCLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHSHAAAWMDLGTLYESCNQPQDAIKCYINATCSKSCSNIPALTARIKCLQAQLCNLQQGSLPSKSKMLPSIEEAWSLPIPAELTSRQGALNTTQQQTTCKAHQSNEAQSQIPSQSLPPHVLSGQTEDQSSPAKKKRTTSPARNSSDSWTNDPGHHQISNWSLTPQKLQLLEQLRNNRANLKPVQLQMLEQLEKQLSLMQQNQQTRLNAMGQIRPSVSNGPVADSSLPTNSNSTPSPHHPHIALSRTPSALTRCAAQPIANGPVPASPVPCSTAGTLGNTDAVSVGNNHLPGSGSNGNVPYLRQNALPHNCTTPTSSSMDDEQWKSQHINSTQGLQKSPGSYSAGPNGEQPFSSTGTSQPSPAAGTGGPNQVGHSATASDTQAQEASHNHLPSPSSQSSATSGGQQGTVNTKESKPSGNGHSVGTPNSTATAEGLPNHVHQGQADTAGAKPRSPGVLSSDNPQLSALLIGKANDSNNSNGGGSAAAGTKVNNVHPSLHKPQENSVASSPCSAMSAASPSPKTADHHSTQNSVNSLNSPTLNGKGLEDSQSPLKVASPLVCHKPTPPSFTLWSSVSIYPSSSDVLKACRNLGKNGVSNNSILLDKCPPPRLPPPPIPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNTANPVTVIRGLAGALKLDLGLFSTKTLVEANPEHLVEVRTQLSQPTDENWDVTGSRKMWRCESSRSHTTIARYAQYQASSFQESLREENEKKGQKDHSDTESAPSENVVRRRRGPFKHIKFGTNIDLSDEKKWKLQLAELSKLPAFARVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVPEPYWGVMNDFCEKNNINYLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWLNTGTVHWVQAIGWCNNIAWNVGPLTVHQYKLAVERYEWNKLQSVKSIVPMIHLSWNMARNIKVSDHKLFEMIKYCLLRTLKQCQMLREALIAAGKELVWHGRTKDEPAHYCSICEVEVFDLLFVTSESNSRKTYVVHCQGCARRCSPNLDNFVVLEQYKIDDLMQVYDQFTLAPPLPSSSSS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0140096 (catalytic activity, acting on a protein), GO:0032451 (demethylase activity), GO:0016491 (oxidoreductase activity), GO:0003676 (nucleic acid binding), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0140457 (protein demethylase activity), GO:0032452 (histone demethylase activity), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0060324 (face development), GO:0009888 (tissue development), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:0008354 (germ cell migration), GO:0016477 (cell migration), GO:1904888 (cranial skeletal system development), GO:0007420 (brain development), GO:0048703 (embryonic viscerocranium morphogenesis), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0007399 (nervous system development), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0007369 (gastrulation), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0060027 (convergent extension involved in gastrulation), GO:0007417 (central nervous system development), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0060026 (convergent extension), GO:0043009 (chordate embryonic development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:1990234 (transferase complex), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:1902911 (protein kinase complex)