Protein: V-type proton ATPase subunit a (A6IER1)
Organism: Rattus norvegicus (Rat)
Function: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR026028: ATPase, V0 complex, subunit 116kDa, eukaryotic (family) [1-797]
- IPR002490: V-type ATPase, V0 complex, 116kDa subunit family (family) [3-796]
Sequence:
MASVFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANVNSFQRKFVNEVRRCESLERILRFLEDEMQNEIIIQVPDKDPGTPLPREMITLETTLEKLEGELQEANQSHQALKKSFLELTELKYLLKKTQDFFEVNLGFTAGVINRERMASFERLLWRVCRGNVYLKFSEMDTLLEDPVTKEEIKKNIFIIFYQGEQLRLKIKKICDGFRATIYPCPEHAAERREMLASVNVRLEDLITVITQTESHRQRLLQEAASNWHSWVIKVQKMKAVYHVLNMCNIDVTQQCIIAEIWFPVADTRHIKKALEQGMELSGSSMVPIMTEVETKTDPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCGHGMVMLMAALWMVLNERHLLAQKSTNEMWNIFFNGRYLILLMGIFSIYTGLIYNDCFSKSFNIFGSSWSVQPMFRNGTWNAHVVEQNPYLQLDPAIPGVYSGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVHMIFGVILSLFNHIYFRRTLNIILQFIPEMIFMLSLFGYLVFMIIFKWCQYDAHTSQKAPSILIHFIGMFLFDYDDSSNAPLYGHQQEVQTFFVIIALVSVPWMLLIKPFILRAKHQKSQLQSFTIHEDAMEGPSVKKTAGAHGTKEGHEEEFNFGDIFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAELSEVLWTMVMSIGLRLRGWGGLVGVFIIFAVFAVLTVAILLVMEGLSAFLHALRLHWVEFQNKFYEGAGFKFSPFSFKHVLEGAAEE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0044877 (protein-containing complex binding), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0042625 (ATPase-coupled ion transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0044769 (ATPase activity, coupled to transmembrane movement of ions, rotational mechanism), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046961 (proton-transporting ATPase activity, rotational mechanism), GO:0015078 (proton transmembrane transporter activity), GO:0009678 (pyrophosphate hydrolysis-driven proton transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0042592 (homeostatic process), GO:0051716 (cellular response to stimulus), GO:0048878 (chemical homeostasis), GO:0009628 (response to abiotic stimulus), GO:0019725 (cellular homeostasis), GO:0042221 (response to chemical), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0070887 (cellular response to chemical stimulus), GO:0070482 (response to oxygen levels), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0071453 (cellular response to oxygen levels), GO:0036296 (response to increased oxygen levels), GO:0055072 (iron ion homeostasis), GO:0036295 (cellular response to increased oxygen levels), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0030054 (cell junction), GO:0031090 (organelle membrane), GO:0008021 (synaptic vesicle), GO:0005886 (plasma membrane), GO:0098590 (plasma membrane region), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0016324 (apical plasma membrane), GO:0030133 (transport vesicle), GO:0070382 (exocytic vesicle), GO:0030672 (synaptic vesicle membrane), GO:0030658 (transport vesicle membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0099501 (exocytic vesicle membrane), GO:0097708 (intracellular vesicle)