Protein: DNA mismatch repair protein (A6H9C6)
Organism: Rattus norvegicus (Rat)
Function: Component of the post-replicative DNA mismatch repair system (MMR)
InterPro domains:
- IPR007696: DNA mismatch repair protein MutS, core (domain) [739-1103]
- IPR000432: DNA mismatch repair protein MutS, C-terminal (domain) [1128-1324]
- IPR007695: DNA mismatch repair protein MutS-like, N-terminal (domain) [409-526]
- IPR016151: DNA mismatch repair protein MutS, N-terminal (homologous_superfamily) [364-533]
- IPR017261: DNA mismatch repair protein MutS/MSH (family) [112-1339]
- IPR007861: DNA mismatch repair protein MutS, clamp (domain) [932-1024]
- IPR007860: DNA mismatch repair protein MutS, connector domain (domain) [540-694]
- IPR036678: MutS, connector domain superfamily (homologous_superfamily) [534-732]
- IPR045076: DNA mismatch repair MutS (family) [412-1337]
- IPR000313: PWWP domain (domain) [88-181]
- IPR036187: DNA mismatch repair protein MutS, core domain superfamily (homologous_superfamily) [736-1068]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1073-1336]
Sequence:
MSRQSTLYSFFPKSPALGDTKEAAARASRKGAAASGASASRGRDAAWSEAGPGSRPAALSTSLPEAKDLNGGLRRSAAPAVPASSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIRKNGKSARVHVQFFDDSPTRGWVSKRMLKPYTGSKSKEAQKGGHFYSSKSEILRAMQRADEALSKDKAQRLELAVCDEPSEPEEEEEEEEEETQVHGAYLSDKSEEENQDESEEETQPNAQGPRRSSRQVKKRRVISDSESDIGGSDVEFKPDSKQEGSSDEVSSGVGDSDSEGLGSFGKGAPKRKRTVAAHGGLKRKSLKKETGSAKQATRILSETKSTLSAFCAPQNSESQTHVCGGGNDSSGPTIWYHETLEWLKPEKRRDENRRRPDHPDYNSSTLYVPEDFLNSCTPGMRRWWQFKSQNFDLVIFYKVGKFYELYHMDAVIGVSELGLIFMKGNWAHSGFPEIAFGRFSDSLVQKGYKVARVEQTETPEMMEARCRKMAHVSKFDRVVRREICRIITKGTQTYSVLDGDPSENYSRYLLSLKEKEEDSSGHMRAYGVCFVDTSLGKFFLGQFSDDRHCSRLRTLVAHYPPVQILFEKGNLSTETKTVLKGSLSSCLQEGLIPGSQFWDATKTLRTLLEGGYFTGNEGSGAELPPVLKAMTSESDSVGLTPGEESELSLSALGGCVFYLKKCLIDQELLSMANFEEYFPLDSDMVGTVKPGAVFTKASQRMVLDAVTLSNLEIFLNGTNGSTEGTLLERLDTCHTPFGKRLLKQWLCAPLCSPSAISDRLDAIEDLMAVPDKVAEVADLLKKLPDLERLLSKIHNVGSPLKSQNHPDTRAIMYEETTYSKKKIIDFLSALEGFKVMCKITRLMEDVADGFKSKTLKQVVTLQTKSPKGRFPDLTAELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLDKQRSRIGCRNIVYWGIGRNRYQLEIPENFATRNLPEEYELKSTKKGCKRYWTKVIEKKLSNLINAEERRDASLKDCMRRLFYNFDKNHKDWQSAVECTAVLDVLLCLASYSQGGDGPMCRPVLLLPGEDTHPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEDAEADGKAYCVLVTGPNMGGKSTLIRQAGLLAVMAQMGCYVPAELCRLTPVDRVFTRLGASDRIMSGESTFFVELSETASILRHATAHSLVLVDELGRGTATFDGTAIASAVVKELAETIKCRTLFSTHYHSLVEDYSKNVCVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFERMNQALQLFREVCLASERPTVNSEAIHRLLALVNQL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0030983 (mismatched DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0007276 (gamete generation), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0007283 (spermatogenesis), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006259 (DNA metabolic process), GO:0048232 (male gamete generation), GO:0006281 (DNA repair), GO:0006298 (mismatch repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)