Protein: Glutaredoxin-2, mitochondrial (A0A8M2B8M4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release
Subcellular location: Mitochondrion
InterPro domains:
- IPR011899: Glutaredoxin, eukaryotic/virial (domain) [52-131]
- IPR014025: Glutaredoxin subgroup (domain) [52-124]
- IPR011767: Glutaredoxin active site (active_site) [54-69]
- IPR002109: Glutaredoxin (domain) [52-114]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [41-136]
Sequence:
MNIWQTREGRSLIRQINVVPVERMGNFSSSAPGLSSSACGQFVQDIVSSNCVVIFSKTTCPYCKMAKGVFNEIGATYKVVELDEHNDGRRLQETLAELTGARTVPRVFINGQCIGGGSDTKQLHQQGKLLPLIEQCRPCCLNMTPEGSGNSQNQPHQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0051540 (metal cluster binding), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0051536 (iron-sulfur cluster binding), GO:0051537 (2 iron, 2 sulfur cluster binding), GO:0015036 (disulfide oxidoreductase activity), GO:0015038 (glutathione disulfide oxidoreductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0048645 (animal organ formation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0043170 (macromolecule metabolic process), GO:0009887 (animal organ morphogenesis), GO:0009888 (tissue development), GO:0016477 (cell migration), GO:0048864 (stem cell development), GO:0001944 (vasculature development), GO:0060973 (cell migration involved in heart development), GO:0060485 (mesenchyme development), GO:0001667 (ameboidal-type cell migration), GO:0036211 (protein modification process), GO:0048863 (stem cell differentiation), GO:0060914 (heart formation), GO:0043412 (macromolecule modification), GO:0007399 (nervous system development), GO:0003007 (heart morphogenesis), GO:0072359 (circulatory system development), GO:0007417 (central nervous system development), GO:0048762 (mesenchymal cell differentiation), GO:0035051 (cardiocyte differentiation), GO:0007507 (heart development), GO:0014033 (neural crest cell differentiation), GO:0090497 (mesenchymal cell migration), GO:0014032 (neural crest cell development), GO:0060974 (cell migration involved in heart formation), GO:0001755 (neural crest cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)