Protein: 3-oxocholoyl-CoA 4-desaturase (P19410)
Organism: Clostridium scindens (strain JCM 10418 / VPI 12708)
Function: Stereo-specific NAD(H)-dependent 3-oxo-delta4-cholenoic acid oxidoreductase involved in bile acid 7alpha-dehydroxylation
InterPro domains:
- IPR023753: FAD/NAD(P)-binding domain (domain) [373-601]
- IPR051793: NADH:flavin oxidoreductase/NADH oxidase (family) [1-521]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [469-638]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [1-370]
- IPR001155: NADH:flavin oxidoreductase/NADH oxidase, N-terminal (domain) [6-326]
Sequence:
MSYEALFSPFKVRGLELKNRIVLPGMNTKMAKNKHDIGEDMIAYHVARAKAGCALNIFECVALCPAPHAYMYMGLYTDHHVEQLKKLTDAVHEAGGKMGIQLWHGGFSPQMFFDETNTLETPDTLTVERIHEIVEEFGRGARMAVQAGFDAVEFHAAHSYLPHEFLSPGMNKRTDEYGGSFENRCRFCYEVVQAIRSNIPDDMPFFMRADCIDELMEQTMTEEEIVTFINKCAELGVDVADLSRGNATSFATVYEVPPFNLAHGFNIENIYNIKKQINIPVMGVGRINTGEMANKVIEEGKFDLVGIGRAQLADPNWITKVREGKEDLIRHCIGCDQGCYDAVINPKMKHITCTHNPGLCLEYQGMPKTDAPKKVMIVGGGMAGMIAAEVLKTRGHNPVIFEASDKLAGQFRLAGVAPMKQDWADVAEWEAKEVERLGIEVRLNTEVTAETIKEFNPDNVIIAVGSTYALPEIPGIDSPSVYSQYQVLKGEVNPTGRVAVIGCGLVGTEVAELLASRGAQVIAIERKGVGTGLSMLRRMFMNPEFKYYKIAKMSGTNVTALEQGKVHYIMTDKKTKEVTQGVLECDATVICTGITARPSDGLKARCEELGIPVEVIGDAAGARDCTIATREGYDAGMAI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0051540 (metal cluster binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:1901265 (nucleoside phosphate binding), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0051536 (iron-sulfur cluster binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0050660 (flavin adenine dinucleotide binding), GO:0010181 (FMN binding), GO:0016628 (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor), GO:0051539 (4 iron, 4 sulfur cluster binding), GO:0071949 (FAD binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006575 (cellular modified amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0097164 (ammonium ion metabolic process), GO:0044248 (cellular catabolic process), GO:0006577 (amino-acid betaine metabolic process), GO:0009308 (amine metabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0042219 (cellular modified amino acid catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0019695 (choline metabolic process), GO:0031455 (glycine betaine metabolic process), GO:0006579 (amino-acid betaine catabolic process), GO:0042426 (choline catabolic process), GO:0009310 (amine catabolic process), GO:0042402 (cellular biogenic amine catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)