Protein: Radixin (Q5WQV5)
Organism: Rattus norvegicus (Rat)
Function: Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein; Cytoplasmic side
InterPro domains:
- IPR011259: Ezrin/radixin/moesin, C-terminal (domain) [508-583]
- IPR018980: FERM, C-terminal PH-like domain (domain) [210-299]
- IPR019748: FERM central domain (domain) [90-206]
- IPR046810: Ezrin/radixin/moesin, alpha-helical domain (domain) [337-456]
- IPR000798: Ezrin/radixin/moesin-like (family) [17-581]
- IPR041789: ERM family, FERM domain C-lobe (domain) [200-296]
- IPR011174: Ezrin/radixin/moesin (family) [2-583]
- IPR019749: Band 4.1 domain (domain) [1-206]
- IPR008954: Moesin tail domain superfamily (homologous_superfamily) [496-583]
- IPR000299: FERM domain (domain) [5-295]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [2-87]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [83-199]
- IPR035963: FERM superfamily, second domain (homologous_superfamily) [89-198]
- IPR018979: FERM, N-terminal (domain) [9-70]
- IPR019747: FERM conserved site (conserved_site) [58-205]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [201-296]
Sequence:
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKRGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLRQIEEQTMKAQKELEEQTRKALELEQERQRAKEEAERLDRERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMCAPPPPPPPAVVPPTENEHDEQDEHSAEASAELSSEGVTNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0065008 (regulation of biological quality), GO:0051641 (cellular localization), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0048523 (negative regulation of cellular process), GO:0033036 (macromolecule localization), GO:0051129 (negative regulation of cellular component organization), GO:0070848 (response to growth factor), GO:0070727 (cellular macromolecule localization), GO:0071495 (cellular response to endogenous stimulus), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0032970 (regulation of actin filament-based process), GO:0090066 (regulation of anatomical structure size), GO:0044087 (regulation of cellular component biogenesis), GO:0031333 (negative regulation of protein-containing complex assembly), GO:0036119 (response to platelet-derived growth factor), GO:0032535 (regulation of cellular component size), GO:1902903 (regulation of supramolecular fiber organization), GO:0010639 (negative regulation of organelle organization), GO:0043242 (negative regulation of protein-containing complex disassembly), GO:0043254 (regulation of protein-containing complex assembly), GO:0043244 (regulation of protein-containing complex disassembly), GO:0033043 (regulation of organelle organization), GO:0032956 (regulation of actin cytoskeleton organization), GO:0008104 (protein localization), GO:1902904 (negative regulation of supramolecular fiber organization), GO:0071363 (cellular response to growth factor stimulus), GO:0032272 (negative regulation of protein polymerization), GO:0036120 (cellular response to platelet-derived growth factor stimulus), GO:0045176 (apical protein localization), GO:0030835 (negative regulation of actin filament depolymerization), GO:0051493 (regulation of cytoskeleton organization), GO:0051494 (negative regulation of cytoskeleton organization), GO:1901879 (regulation of protein depolymerization), GO:0032271 (regulation of protein polymerization), GO:0030837 (negative regulation of actin filament polymerization), GO:0110053 (regulation of actin filament organization), GO:0030832 (regulation of actin filament length), GO:1901880 (negative regulation of protein depolymerization), GO:0008064 (regulation of actin polymerization or depolymerization), GO:0030833 (regulation of actin filament polymerization), GO:0051693 (actin filament capping), GO:0030834 (regulation of actin filament depolymerization), GO:0051016 (barbed-end actin filament capping)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031252 (cell leading edge), GO:0005622 (intracellular anatomical structure), GO:0030496 (midbody), GO:0043226 (organelle), GO:0030315 (T-tubule), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0032153 (cell division site), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0060187 (cell pole), GO:0098590 (plasma membrane region), GO:0051286 (cell tip), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0032154 (cleavage furrow), GO:0070161 (anchoring junction), GO:0005938 (cell cortex), GO:0030027 (lamellipodium), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0098858 (actin-based cell projection), GO:0042383 (sarcolemma), GO:0005911 (cell-cell junction), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0005912 (adherens junction), GO:0030175 (filopodium), GO:0030864 (cortical actin cytoskeleton), GO:0005902 (microvillus), GO:0015629 (actin cytoskeleton)