Protein: Intraflagellar transport protein 122 (A8BJ15)
Organism: Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia)
Function: Component of the intraflagellar transport complex A (IFT-A) involved in flagellar assembly (Probable)
Subcellular location: Cell projection, cilium, flagellum . Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body. Note=Localizes to the cytoplasmic and membrane-bound portions of each of the eight axonemes, localizing particularly at the flagellar pores and at the distal flagellar tips. Localizes to the basal bodies
InterPro domains:
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [2-732]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [14-669]
- IPR001680: WD40 repeat (repeat) [2-664]
- IPR039857: Intraflagellar transport protein 122/121 homolog (family) [1-1706]
- IPR056152: IFT122, second beta-propeller domain (domain) [447-681]
Sequence:
MKVEPLWSLDVGTQPVYSLVRTPDGTKMYAATGKTVVTFGPGPEITRQTSTQHPLVTCLAISPDGHMVVSMGTDGAVMFNDSTGAALFKYSHQNEVQAAAFSPDGSLFVSAAIGDVGIYHCRDVKTKVMKQSFKGTPRAIAWAPGSDWFVISTQDGDLVIMTPEGMELNSCNLGAPAWALKVVQCSSFLVQPNTALDVDIANSSDDEFTIPQTVTPSASASGRSGSGKRHKVELDREEFITSHNMDNFRILVASWDMRYRVINPSVYADGACIAKMTDGGSDSRSRSSSRRRLDGLLVAVSEIPFIPLCMEIIGNYVFLSGVGGSVVVLNSSNGRVLSSLYQVWESDPFISKAPLIPTESQSKHLPQKRTIMGQVTTCTDVNQRLMELRKREAMANRNVKNVTNPLAFHGMHTIWCYSMIHVEPSSLILGLSNGVLLCLSLRYAMIHSQYGSLYAYRRGLMSVSVMNLSTGRESILEVGMHVENLSIYESTLAIKTSSRLLLYRLQDPALKKRNIESVMDYYSSSTNGLIETDRSRRQNMSSLSYSFETSIKKRFVCSQLIVSNNHFFLCNVSHISVHDFSGKQTDRWTFKQLKCTYVRSIGGIPSNEAVLVGFDTGKVCIFKIGNKFPIELLLHRSPIVSLDISPDRKYISVVDRSDVVSVYKFLDDSEIVLGATNMAVVEHENTPTSYSRIAALAHVSLDGNLPGITTGQDYSVPLYTFKGTTSAIWDLVLPGVLARSTQKSVDICIDSGVSYTFQLSYPGSFVLCQNGNRAFIFNVSYLGQSLVNLDYSSLIEMVEVPMMPMVIYRTHKVLRMLLDSNYEAGAVFPSQAANYELNEAIKAANLGVPMDCWRDLAIAALLSNELDLAREVLATIGDIRSLKAIAEITRQTSTKTYLLLSALALSMCDHFSEASLLFAASDDIQMATELLFFINRECIPYNSPNSSLISSIAKKLICRELHSSLTGTEEKILEVLKTQGDSTYSPLGTQTAPEAKETNTALLTDFSDKLLAKGRATVNKFLSAIESGSSKADGPGNDNKDTYNYFNDYRILLRRQISSFAKTESERANLVVRHSKFLETSLEWRAAAASYLDMDDPESAIDVLITSKQTGALLRLVRIFPPVARELNHKAPSFNDFESPEDADEYAPSSVQNQMLKRAYRKALVYFEKSNDYSNAIFIAQRLGDPLVLLRLLIQQGSWSQVEALGKAYPEMMPSIHEAKASMLLREGRFIEALERLRLSGNTSKEAIIIKQLIDASIAECKFNLTRALTGQLAKQIAKTRAFAALSVSSMEYYAAIKAIRARVLVYTGYQQVMEYMVNILRSRDLSDITMIRLHDNTQSAKVVTAGIFLTSYAAMANELTNADSVFSEELENNTGILSGEDTVKASSQRSKKDNPPSLRSTIGFITSSTTPQLGSLAHIDLGINNMNIPPGISELIIWVCLALASRRTYPEVEARALKRILASRIPGPMIGYFRRQMLLVKGTPAKDFSHGESSDAESRDACPRCAAPLKALPPSRPVGAQDMAILSSLPHCCPVFSDICKNCGSPIVRSALSLKILPLVLAEPDDETSIAVALERAAAVEMDIEALMGETNRLEIGTDDLQTDEGVVDVLRRASIAGDGRGAVLTSEQFEKISPANIFIVDDTWSNPSLLPRFVVGNVIKRFFIRTISDFQLHYCTGCGFFFDGIEYEEYVIVTGSCPICGATNIVL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0031503 (protein-containing complex localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0042073 (intraciliary transport), GO:0007018 (microtubule-based movement), GO:0044085 (cellular component biogenesis), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0010970 (transport along microtubule), GO:0030030 (cell projection organization), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0035721 (intraciliary retrograde transport), GO:0006996 (organelle organization), GO:0099111 (microtubule-based transport), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0060271 (cilium assembly), GO:1905515 (non-motile cilium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm)