Protein: DNA ligase (A6IWS2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus
InterPro domains:
- IPR012309: DNA ligase, ATP-dependent, C-terminal (domain) [476-588]
- IPR021536: DNA ligase IV domain (domain) [750-782]
- IPR012308: DNA ligase, ATP-dependent, N-terminal (domain) [15-208]
- IPR036599: DNA ligase, ATP-dependent, N-terminal domain superfamily (homologous_superfamily) [1-250]
- IPR012310: DNA ligase, ATP-dependent, central (domain) [248-489]
- IPR016059: DNA ligase, ATP-dependent, conserved site (conserved_site) [271-451]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [454-609]
- IPR036420: BRCT domain superfamily (homologous_superfamily) [626-911]
- IPR000977: DNA ligase, ATP-dependent (family) [81-602]
- IPR044125: DNA Ligase 4, adenylation domain (domain) [235-455]
- IPR029710: DNA ligase 4 (family) [1-910]
- IPR001357: BRCT domain (domain) [654-911]
Sequence:
MASSQASRTVAAHVPFADLCSTLERIQKGKDRAEKIRHFKEFLDSWRKFHDALHKNKKDVPDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPREGKDAQKLLNYRTPSGARSDAGDFATIAYFVLKPRCLQKGSLTIQKVNELLDLVASNNSGKRKDLVKKSLLQLITQCSALEQKWLIRMIIKDLKLGVSQHTILSIFHNDAVELHNVTTDLEKVCRQLHDPSVGLSDISITLFSAFRPMLAAVADVERVEKDMKQQSFYIETKLDGERMQMHKDGALYRYFSRNGYNYTDQFGESPQEGSLTPFIHNAFKTDVQVCILDGEMMAYNPTTQTFMQKGVKFDIKRMVEDSDLQTCYCVFDVLMVNNKKLGRETLRKRYDILSSTFTPIQGRIEIVQKTQAQTKQEVVDALNDAIDKREEGIMVKHPLSIYKPDKRGEGWLKIKPEYVTGLMDELDLLIVGGYWGKGSRGGMMSHFLCAVAETPPPGDKPSVFHTLCRVGSGYTMKELYDLGLKLAKYWKPFQRKSPPSCILCGTEKPEVYIEPQNSVIVQIKAAEIVPSDMYKTGSTLRFPRIEKIRDDKEWHDCMTLDDLEQLRGKASGKLATKHLHIGDDDEPREKRRKPISKTKKTIGIIEHLKAPNLSNINKVSNVFEDVEFCVMSGLDGYPKPDLENKIAEFGGYIVQNPGPDTYCVIAGSENIRVRNIISSDRHDVVKPEWLLECFKTKTCVPWQPRFMIHMCPSTKQHFAREYDCYGDSYFVDADLDQLKEVFLRIKPSEQQTPEEMAPVIADLECRYSWDHSPLSMFRHYTVYLDLYAVINDLSSKIEATRLGVTALELRFRGAKVVSRLSEGVSHVIIGEDQRRVSDFKTFRRTLKKKFKILQERWVIDSVDKCELQEENLYLL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0016874 (ligase activity), GO:1901363 (heterocyclic compound binding), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0097367 (carbohydrate derivative binding), GO:0003676 (nucleic acid binding), GO:0016886 (ligase activity, forming phosphoric ester bonds), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0140097 (catalytic activity, acting on DNA), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0003677 (DNA binding), GO:0032555 (purine ribonucleotide binding), GO:0003909 (DNA ligase activity), GO:0017076 (purine nucleotide binding), GO:0005524 (ATP binding), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0010035 (response to inorganic substance), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:1902074 (response to salt), GO:0010038 (response to metal ion), GO:0006259 (DNA metabolic process), GO:0010226 (response to lithium ion), GO:0071241 (cellular response to inorganic substance), GO:0090304 (nucleic acid metabolic process), GO:1901701 (cellular response to oxygen-containing compound), GO:1902075 (cellular response to salt), GO:0071248 (cellular response to metal ion), GO:0071285 (cellular response to lithium ion), GO:0006266 (DNA ligation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)