Protein: Abnormal spindle-like microcephaly-associated protein isoform X1 (A0A8M2B8W4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [42-139]
- IPR051185: Abnormal Spindle-like Microcephaly-associated (family) [27-1507]
- IPR036872: CH domain superfamily (homologous_superfamily) [766-1258]
- IPR000048: IQ motif, EF-hand binding site (binding_site) [1261-3158]
- IPR016024: Armadillo-type fold (homologous_superfamily) [3186-3283]
- IPR031549: Abnormal spindle-like microcephaly-associated protein, ASH domain (domain) [35-132]
- IPR001715: Calponin homology domain (domain) [920-1257]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1346-3041]
Sequence:
MSFKVAKSECLDFSPPLDSHCSRDKSGKENSSSIPVLSLLQFSRAPFVSFGTIKLGSSKSLPLRIENPTDDATATVIVDKISASKGFSVDQMSFTIQPEDSIILTVTWTPVEEGGIRELLCFIANGIVKHQAILLGKAETTKKKKKTLWDSIKSKKGVPAPSKEKKVSTMPIKSVNKTFHVSRQSQYRKDRTSNPLSPLNQNGSRRVNTPSSTPEMPKPAFITETFDNVHLQKDSPVVVLVPAERLLDTPGKKDAPSSRQIECREITRVLNKTLSPASTPERFRNPLSSGFQSPLPVIGQFVQDKSREPEKLSLSVKDALDVIGSDLSHTVSPPNACSSFDFSDSLESDKPDPGASFRARRVISPPVETADPRLTFCVKPNKAIGIASNQDEFRLKALPFSTATVTKSIKVDDTHVPDDPKTFPVNSATVVKSKADASVESPGLRKKKTSRRRLLEKTLELSEPSNAESNTSSPDSFSALPVINSDSSPDLPLESKICPVAKKKPTLNLSPHDQLLSSISPIRPQVFPSVSNSPSSSLELSASHFSEKVKPNLLENQFPVQSRTLVQSKKRKSDEFLRGHSEDKSNIQAKKCRAPAQATEKPSQERTLTSRSTSGPQRKAVAPPSSRKFTRFPPKKISPKTAQKDARSVKSANSSTRKTARIVAVAQARLTFMKPTQTAIPRHPLPFAAKNMFYDERWIEKQERGFTWWMNYILTPDDFKVATEVTKVNALSLTMGNDKFNIPKAPTKEEMSFRTYTARQRLNRLRRAACKLFTSEAMVKAIQRLELEVEAKRLLVRKDRHLWKDIGERQKVLNWLISYNPLWLRIGLETIYGELISLESNNDVMGLAMFILGRLLWNPDLAAEFRHSKVPHLYRDGHEEALSRFTLKKLILLVCFLDKAKESRLIEHDPCLFCMDAEFKSSKDLLLAFSRDFLSGEGILSRHLSHLGLAVSHVQTPLDEFNFAVKKLAVDLKCGIRLVRVMELFTLDWTLSRKLRIPAISRLQKVHNVDLALQVLKNKGVDLRDEHGANIDSRDIVDGHREKTLNLLWKIIFAFQVEVLLDENQLKEEISFLRKTWRTKQKLASIMANNSVTVSRMKARRAFEHPSQKVTLLMDWVNAVCEFYSLKAENFTVSFSDGRILCYLIHHYHPGHLHAEEIQQRTTQTIECGHRGRVELNNSSSDSDCSFENLATMQSESVTVDFRELLENEKSNFQLVNTAVSYLGGVPAMINPEDMSNTIPNEKVVTCYLSFLCARLLDLRNETRAARVIQGAWRRYKLQKDIALMHEKNLAATKIQALARKFILKRRLIRQNKAAVKIQTLWRGYSAREKLRVLKKERHYALQNAAATLIQKTYKAWRVKNLLKKNRSAFVIQAAFRKWHAKKMLERNTAALRIQAWYRMQLCKRQYLEMKRKAVCVQAWFRGHLQRSKFQNLKKRHHASVVIQSAFRAYLIRKELSKMKQNAVLIQRWFRACVQRKAEQKRYFEIKSAVLVLQAAFRGWKVRKSVAQHHRSALVIQTAFRRFTAQRHFLCLKRSAIVLQQRYRAKVHGGKFRKEYMALKSASVRIQAMWRGRAERKKISQLHRFAKIIQSNYRRHLEQTRFLQMKRAAVVIQRQYRAFRDGQKVHAEYTKIKRAAIILQSAYRGRRIRQELQRKNKAATLIQSVMRAHMCHQQFLAQKHAAIVIQQQFRAFTFGRMERSHYMRLRKATITMQAIYRGSKVRQNLKREHQAATVIQAQFRMHKVRIPFVAAKCAAILIQQHYRAYKVGKTVQATYLQMKNAAVVIQSAFRGMKVRNYLRKSHQAAKVIQAHFRGHSQLKKYRRQQWAASVLQQRFRATVTKNAVMKQYAAIKTATICIQSAFRGMVARKQIAEKQKCAKIIQKMYRAYKQRHDYLALRNATIRIQQQYRAVVSARQQHQRYCSLRAAAITLQSSYRGLRARKEINRRQKAATVIQAAYKMYRTRVPFQAMKLASLVIQRQYRCHLLRKKARENFLKLKQSAVAIQAIYRGKLARRDLARRHFAATIIQRKYLAYKQRKCFLTLQAAVIFCQQHYRSILLTRHDRKDYLTKRRAVVAIQASFRGMNVRRQIRREHKAATIIQSHVRMRILNLRFQRLRWAVCTVQQRFRANKIMRQEMAALQEKKSAALILQAAYRGKKTRQALKQMHQAATIIQSHVRMRILNLRFQRLRWAVCTVQERFRANRIMRQEMAALQEKKSAALILQAAYRGKKTRQALKQMHQAATIIQSHVRMRILNLRFQRLRWAVCTLQRHFRANKIMRQEMAALQEKKSAALILQAAYRGMKTRHTLKQMHQAATIIQSHVRMRILNLRFQRLRWAVCTVQQRFRANRIMRQEMAALQEKKSAALILQAAYRGMKTRQTLKQMHQAATIVQATYRAYSGRKRYLEMKCAAIDIQQRYRAVNAAKQQRKSYLKVRQGALVLQACYRGRKVRRNLQLQCQAAVLIQSYFRRHKEMVKYQAMKLSAVIIQSHFRSYIQARADRKNYQHLRKSAIVIQAAFRGHSLRRHLARKQEASVIIQASFRMYQQRSAFKKQRWAARVLQQRFRALKLRDEHVCQYQQVRNAAVCLQRYFRGMKGRELARRSKAARTIQSFLRMSVQRQRFMKEKAAAIAIQSAYRGHFARAQYTRMQAGTVLIQKWYRSRKLVQEDRKRFVAVRQATLTLQSALRGMLVRRLAKRRRAAIKIQSVMRMHIQRKRYVTLRASALKFQAHYRMLVAQRKYRRLQAATVTLQKHYRSHRATLEQRCSYLKTLQNIKKLQARVRGHIAYKRFQRLRTCAITIQANYRGMIERRRFHQLKECALVIQKHYRAFILCQKERSKFLQLRQSAVVIQRAYRAYQKRQNAMKAQAALKIQAWFRGRLARRNYILKQAASATIRRCIQARRQRSKFLAVQHSVRVIQQRWRETLSSRKQHAEFLKLIKSVIYIQALWRGRRLRDSIQKQATAAVKIQSAFRGSIQRRRYHQQRNAAITLQRHFRVLRLARVKEENLRRRHNAAIYIQALWRGWLARQQVKEMAFAARRLRFTAAVYHHLSAIKIQRAVRAHWALKSAKKKISSVLYIQQCFRAKLQRKKYLKDREDIIKTQRAVRSWLHRRNQAASIIQHAVRKLLFRRRKERLQRGIIRAQALWRGHCSRKLHDTNKVISMRQRLREVNQRVKEEDKLCNKTTTALTYLLGLQNYAFILAALKHLETATRLSPECCERLVESGATHTIFTLIRSCNRSVPSMEIITLSIQVLLNLSKYHRTIDAVYDVDNSVETLLDLLQIYREKAGDKVADKGGSIFTKTCFLLVLLVQDERRAMEIRRLPKVMDRIRSIYRLTLRKCKMDAERNKVKQKMNTSLNGSFLLQATPRKSKPVARFAPDWVLRRDKMKDIVDPLRAIQILANALAIVP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005516 (calmodulin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007049 (cell cycle), GO:0000278 (mitotic cell cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000922 (spindle pole), GO:0005813 (centrosome), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0005819 (spindle), GO:0015630 (microtubule cytoskeleton)