Protein: Toll-like receptor 1 (A6JDF9)
Organism: Rattus norvegicus (Rat)
Function: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides
Subcellular location: Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR017241: Toll-like receptor (family) [43-829]
- IPR035897: Toll/interleukin-1 receptor homology (TIR) domain superfamily (homologous_superfamily) [670-830]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [113-536]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [71-545]
- IPR000157: Toll/interleukin-1 receptor homology (TIR) domain (domain) [680-830]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [569-623]
- IPR001611: Leucine-rich repeat (repeat) [115-513]
Sequence:
MLLVKNSGERGQVCTPLQKLSLYPSGDALMNSSSLKHVYCHTMTKTQSTIFYCIVVLGLILIKIQLSEESELIIKRPNANLTRVPKDLPLQTTTLDVSQNNISELQTSDILLLSKLRVFIMSYNRLQYLNISVFKFNTELEYLDLSHNELRLISCHATADLKHLDLSFNAFDALPICKEFGNLSQLQFLGLSGSQIQNSSVQLIAHLNISKVLLVLGDTYGEKEDPKCLQHISTETLHIVFPSKREFHFLLDMSVSTAISLELSNIKCVLEDKNCSYFLGTLERLRKTQRLSNLTLNNVDTTWNSFINILQLVWHTPVKSFSISNVKLKGHFNFRRFHYSDTSLRALSIHQVVTDVFSFPQSNIYSIFSNMNIQSFTVSGTRMVHMLCPDQISPFLYLDFTDNLLTDIVFEDCRNLIRLKTLSLQKNQLKTLENIILMSMEMTSLQKLDISQNSLRYSDAGSPCSWTQSLLVLNLSSNMLTDSVFRCLPPKVKVLDLHNNRIVSISKDVTHLQALQELNVASNFLTDLPGCGAFSSLSVLVIDHNSVSHPSSDFFQSCQNIRSITAGNNPFRCTCELREFVKNIGQASREVVEGWPDSYRCDYPDSIKGTPLQDFHMSPLSCDTILLTVTIGATLLLLAAIGASLCLYFDLPWYLRMLWQWTQTRHRARNIPLEELQRNLQFHAFVSYSGHDSAWVKNELLPNLEKDDIRVCLHERNFVPGKSIVENIIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPIPQYSIPTNYHKLKTLMARRTYLEWPTEKSKHGLFWANLRASINVKLVNQAEATCYTQQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0033218 (amide binding), GO:0008289 (lipid binding), GO:0042277 (peptide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0001775 (cell activation), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002682 (regulation of immune system process), GO:0006950 (response to stress), GO:0002253 (activation of immune response), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0002764 (immune response-regulating signaling pathway), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0050776 (regulation of immune response), GO:0043207 (response to external biotic stimulus), GO:0002757 (immune response-activating signaling pathway), GO:0002269 (leukocyte activation involved in inflammatory response), GO:0002833 (positive regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0009617 (response to bacterium), GO:0006952 (defense response), GO:0050778 (positive regulation of immune response), GO:0032101 (regulation of response to external stimulus), GO:0002274 (myeloid leukocyte activation), GO:0031349 (positive regulation of defense response), GO:0061900 (glial cell activation), GO:0010033 (response to organic substance), GO:0002218 (activation of innate immune response), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0006954 (inflammatory response), GO:0002758 (innate immune response-activating signaling pathway), GO:0045088 (regulation of innate immune response), GO:0042116 (macrophage activation), GO:0002237 (response to molecule of bacterial origin), GO:0001774 (microglial cell activation), GO:0002221 (pattern recognition receptor signaling pathway), GO:0150076 (neuroinflammatory response), GO:0002224 (toll-like receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)