Protein: Fibroblast growth factor receptor (A6IK52)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR050122: Receptor Tyrosine Kinase (family) [88-748]
- IPR013098: Immunoglobulin I-set (domain) [160-239]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [607-619]
- IPR016248: Fibroblast growth factor receptor family (family) [33-790]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [466-742]
- IPR000719: Protein kinase domain (domain) [466-755]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [40-355]
- IPR003598: Immunoglobulin subtype 2 (domain) [50-340]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [47-350]
- IPR007110: Immunoglobulin-like domain (domain) [39-349]
- IPR017441: Protein kinase, ATP binding site (binding_site) [472-502]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [466-742]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [457-742]
- IPR003599: Immunoglobulin domain subtype (domain) [44-351]
Sequence:
MVVPACVLVFCVAVVAGVTSEPPGPEQRVGRRAAEVPGPEPSQQEQVAFGSGDTVELSCHPPGGAPTGPTLWAKDGVGLVASHRILVGPQRLQVLNATHEDAGVYSCQQRLTRRVLCHFSVRVTDAPSSGDDEDGEDVAEDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDRELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELMEVDEAGSVYAGVLSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKVSRFPLKRQVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTPSSSSSGDDSVFTHDLLPPGPPSNGGPRT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0060089 (molecular transducer activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0038023 (signaling receptor activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004888 (transmembrane signaling receptor activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0019838 (growth factor binding), GO:0016301 (kinase activity), GO:0019199 (transmembrane receptor protein kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004713 (protein tyrosine kinase activity), GO:0017134 (fibroblast growth factor binding), GO:0004714 (transmembrane receptor protein tyrosine kinase activity), GO:0005007 (fibroblast growth factor receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0007267 (cell-cell signaling), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0042127 (regulation of cell population proliferation), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0007166 (cell surface receptor signaling pathway), GO:0008284 (positive regulation of cell population proliferation), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0071774 (response to fibroblast growth factor), GO:0071363 (cellular response to growth factor stimulus), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0044344 (cellular response to fibroblast growth factor stimulus), GO:0008543 (fibroblast growth factor receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0009986 (cell surface), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)