Protein: NADH-ubiquinone oxidoreductase chain 4L (P03901)
Organism: Homo sapiens (Human)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the enzyme membrane arm which is embedded in the lipid bilayer and involved in proton translocation
Subcellular location: Mitochondrion inner membrane ; Multi-pass membrane protein
InterPro domains:
- IPR001133: NADH-ubiquinone oxidoreductase chain 4L/K (family) [5-98]
- IPR039428: NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like (family) [4-98]
Sequence:
MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0022804 (active transmembrane transporter activity), GO:0008137 (NADH dehydrogenase (ubiquinone) activity), GO:0015399 (primary active transmembrane transporter activity), GO:0003954 (NADH dehydrogenase activity), GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor), GO:0015453 (oxidoreduction-driven active transmembrane transporter activity), GO:0050136 (NADH dehydrogenase (quinone) activity), GO:0003955 (NAD(P)H dehydrogenase (quinone) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0022900 (electron transport chain), GO:0022904 (respiratory electron transport chain), GO:0045333 (cellular respiration), GO:0019646 (aerobic electron transport chain), GO:0009060 (aerobic respiration), GO:0042773 (ATP synthesis coupled electron transport), GO:0006120 (mitochondrial electron transport, NADH to ubiquinone), GO:0042775 (mitochondrial ATP synthesis coupled electron transport), GO:0006119 (oxidative phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0031975 (envelope), GO:0016020 (membrane), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0070469 (respirasome), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:1902495 (transmembrane transporter complex), GO:0005746 (mitochondrial respirasome), GO:0098803 (respiratory chain complex), GO:0043229 (intracellular organelle), GO:1990204 (oxidoreductase complex), GO:0098800 (inner mitochondrial membrane protein complex), GO:0030964 (NADH dehydrogenase complex), GO:0043227 (membrane-bounded organelle), GO:0005747 (mitochondrial respiratory chain complex I), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0045271 (respiratory chain complex I), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)