Protein: [histone H3]-trimethyl-L-lysine(4) demethylase (A0A8M6Z830)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
- IPR048615: Lysine-specific demethylase 5, C-terminal helical domain (domain) [636-690]
- IPR004198: Zinc finger, C5HC2-type (domain) [722-774]
- IPR019786: Zinc finger, PHD-type, conserved site (conserved_site) [342-386]
- IPR036431: ARID DNA-binding domain superfamily (homologous_superfamily) [56-189]
- IPR013637: Lysine-specific demethylase-like domain (domain) [787-1117]
- IPR001606: ARID DNA-binding domain (domain) [79-170]
- IPR019787: Zinc finger, PHD-finger (domain) [339-389]
- IPR001965: Zinc finger, PHD-type (domain) [341-1293]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [1222-1299]
- IPR003347: JmjC domain (domain) [483-649]
- IPR003349: JmjN domain (domain) [13-55]
- IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [328-1303]
Sequence:
MMDVGEEFVPPPECPVFEPSWEEFADPLGYIAKIRPIAEKSGICKIRPPPDWQPPFAVEVDNFHFTPRIQRLNELEAETRVKLNYLDRIAKFWEIQGSSLKIPNLERRILDLFSLAKIVTEEGGFESVSKERRWARVAQKLGYPPGKNIGSLLRSHYERIVYPFELFQSGASLPPRKPRQYDSDEVDREYKPHSIPLRQSVPPSKMSSYGRRANRLQPEPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLVPRDKTRKKDDLPQTVIVRDSAVKDEPAETAVTKSDPDIPPPPPNLIIKEDVDDDKSHIDKPNDPSDEPCTKMTMRLRRNLNNPQFVDSFVCRMCGRGDEDEKLMLCDGCDDNYHTFCLIPPLTDPPKGNWRCPKCVAEECKKPSEAFGFEQATREYTLQSFGEMADTFKADYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVNNGKRQLSEEEEEYARSGWNLNVMPVLEQSLLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPCSAAEKLEEVMKKLTPELFEFQPDLLHQLVTIMNPNILMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPTGRSCIEHYRQLRRYCVFSQEELTCKMAACPEKLDLNLAAATHREMFIIVQEERKLRKSLLERGIKEAEREAFELLPDDERQCDKCKTTCFLSALACSNCPERLVCLYHAQDLCSCPSEKLYLRYRYTLDELLAMLHRLKVRAESFDSWANRVKEALEQDEGNKIDIKDLEVLKEEAADKKFPNNELLQRLNTVFVDIEKCESCSTELLSNSQSSRMTLKELKTLVDTMQNLPCVIKQQDEVQLILQKIEEFDSRAQVLVDSTKSEWKQDSPLPVATEIQALLEEGASLPVIAPACELLSGLLEQGRWLGEVRRTLGPEGSEVTLTVLRNLMESGCNVPQSVSVETAMAELQELLTIAERWEEKAQICLEDRQKHHLSTLEAIVNEAQLIPVQLPNILSLQACLSRARAWVTDLEEIQNGEHYPCLDDLEGLVAIGRDLPVKMEELKQLELQVASAHSWREKASKTFLKKNSQHSLLEVLCPCVEKSKKMEDNSMVTEADSDVNVLGLTAQDLRDPGAIVMAFKEGERLEKEALLRLQQVNLAKPSIENGVSTDQDSIKTEKKQSNSMETDVPLNSDSPVLQNGGSSHSLTSSQTVCICGGPPRPLLHRCHLCKDWFHGGCVSFPPLLATSDTHLTKPLCWWDWNTRFLCPRCQRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAINWQGRAKQALDTPEVQEALDRLQQVEDEMVSIKEEEPEEKKKWNGDAVIVLSDSEEAEDGVIDLTEDGNSPKKNERNAVNGTQSGCENGIGRKSSAHEVTGVESLLSLVPSLKGPVVELNTSVRAQLEELQLEGDLLEVTLDQTHAIYRILQASSQPPQDTLRTLIQIELQEQRSSGRGNKSKDSKRKRKSQKTEGEPKSTEASDCKKTKALNLSPPTDTHTDVVMFS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0032451 (demethylase activity), GO:0140457 (protein demethylase activity), GO:0032452 (histone demethylase activity), GO:0032453 (histone H3K4 demethylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:1901214 (regulation of neuron death), GO:1901215 (negative regulation of neuron death), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0043066 (negative regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0043524 (negative regulation of neuron apoptotic process), GO:0043523 (regulation of neuron apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)