Protein: Mediator of RNA polymerase II transcription subunit 14 (A0A8M1PFL7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors
Subcellular location: Nucleus
InterPro domains:
- IPR056878: Mediator of RNA polymerase II transcription subunit 14, RM5 (domain) [651-736]
- IPR055113: Mediator of RNA polymerase II transcription subunit 14, RM2 (domain) [301-380]
- IPR013947: Mediator complex, subunit Med14 (family) [24-1415]
- IPR055107: Mediator of RNA polymerase II transcription subunit 14, RM8 (domain) [1188-1259]
- IPR056879: Mediator of RNA polymerase II transcription subunit 14, RM3 (domain) [383-490]
- IPR055122: Mediator complex subunit MED14, N-terminal (domain) [34-222]
- IPR055114: Mediator of RNA polymerase II transcription subunit 14, RM6 (domain) [780-846]
- IPR056877: Mediator of RNA polymerase II transcription subunit 14, C-terminal domain (domain) [1275-1416]
Sequence:
MAPVQIGSDGQLVPAGGPTSTPQPPPGAPATQGVRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAYLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQVNYIHELVQSRLFGDDKPLQDMYTCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYIPAKCLTLSVWNQQVLGRKTGTASVHKVTIKIDESDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKSSNPNDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGVDQSMLDDIEKSINDDMKRIVTWLLQLKFWLGEQRCRQSVKHLPTLCTDTLHLSNLTTHPVGNLSKHRLFIKLTRLPQYYIVVEMFDVPSNLTELQYKYYFLSVSQMESEDGLPSAQLFRHFKPNLEELVQDISSCRMVRPGTKRKLSGEQSAVEPKKPKRSGEMCAFNKELAHLVAMCDTNMPLIGLRSELSNMEIPHQGVQVEGDGCSHAIRILKVPPCMAVGEETRKALERSLLDCTFRLQGRNNRTWVAELIFSSCPLNSTSIKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNSISKLYECVLEFSRSLTEMPSYLSLFSEIRLYNYRKLVLCYGSTKGSSVTIQWNSVTHRYHLALGTVGPNSGCSNCHNIILHQLQEMFNKTPNVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPISMEDTFMPHTQTQPPGRGVYPPLTSPPNPYHVPPSPSMITTQSPAGNIHAANSPSGALRAPSPFGPTPSPSSLGISMGQTSNFASPHGTLDPSSPYTLVSASPRVGPWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPSHSPRAGTSSQAMPPPRKLPQRSWAASIPTILTHSKLHVLLLPSPMPCPVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEPNLTIVNSNEPGVIMFKTEVLKCRVALNPKSYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLNWNVQFCLTIPPSAPPIAPPGTIAVVLKTKMLFFLQLTQRLPVPQEPISIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSSILRRFNEHHPPRPGECTIFAAVHELMANLTLNSGGRP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0005488 (binding), GO:0003712 (transcription coregulator activity), GO:0005515 (protein binding), GO:0003713 (transcription coactivator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0098727 (maintenance of cell number), GO:0019827 (stem cell population maintenance), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0001568 (blood vessel development), GO:0060322 (head development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:1904888 (cranial skeletal system development), GO:0035239 (tube morphogenesis), GO:0007420 (brain development), GO:0048703 (embryonic viscerocranium morphogenesis), GO:0048863 (stem cell differentiation), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0007399 (nervous system development), GO:0048514 (blood vessel morphogenesis), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0021591 (ventricular system development), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0007417 (central nervous system development), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0014033 (neural crest cell differentiation), GO:0043009 (chordate embryonic development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0016592 (mediator complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)