Protein: Protein disulfide-isomerase A3 (A0A8I5KNU9)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum lumen. Melanosome
InterPro domains:
- IPR041868: Protein disulfide-isomerase A3, first redox inactive TRX-like domain b (domain) [135-240]
- IPR017937: Thioredoxin, conserved site (conserved_site) [49-67]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [24-439]
- IPR005788: Protein disulfide-isomerase, thioredoxin-like domain (domain) [30-131]
- IPR013766: Thioredoxin domain (domain) [19-438]
Sequence:
MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREATNPPVIQEEKPKKKKKAQEDL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0065009 (regulation of molecular function), GO:0051050 (positive regulation of transport), GO:0048522 (positive regulation of cellular process), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0044085 (cellular component biogenesis), GO:0051282 (regulation of sequestering of calcium ion), GO:0032409 (regulation of transporter activity), GO:0032411 (positive regulation of transporter activity), GO:0043270 (positive regulation of monoatomic ion transport), GO:0034762 (regulation of transmembrane transport), GO:0016043 (cellular component organization), GO:0034764 (positive regulation of transmembrane transport), GO:0034767 (positive regulation of monoatomic ion transmembrane transport), GO:0051928 (positive regulation of calcium ion transport), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0032414 (positive regulation of ion transmembrane transporter activity), GO:0022898 (regulation of transmembrane transporter activity), GO:0043933 (protein-containing complex organization), GO:0043269 (regulation of monoatomic ion transport), GO:0051279 (regulation of release of sequestered calcium ion into cytosol), GO:0022607 (cellular component assembly), GO:2001259 (positive regulation of cation channel activity), GO:1901021 (positive regulation of calcium ion transmembrane transporter activity), GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol), GO:0065003 (protein-containing complex assembly), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:1904064 (positive regulation of cation transmembrane transport), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:0010959 (regulation of metal ion transport), GO:1904427 (positive regulation of calcium ion transmembrane transport), GO:0051258 (protein polymerization), GO:0051924 (regulation of calcium ion transport), GO:2001257 (regulation of cation channel activity), GO:1901019 (regulation of calcium ion transmembrane transporter activity), GO:1903169 (regulation of calcium ion transmembrane transport), GO:1901339 (regulation of store-operated calcium channel activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)