Protein: Ferrochelatase (A6IXN8)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the ferrous insertion into protoporphyrin IX
Subcellular location: Mitochondrion inner membrane
InterPro domains:
- IPR033659: Ferrochelatase, N-terminal (domain) [68-229]
- IPR001015: Ferrochelatase (family) [59-404]
- IPR033644: Ferrochelatase, C-terminal (domain) [234-371]
- IPR019772: Ferrochelatase, active site (active_site) [257-275]
Sequence:
MLSAGANMAAALRAAGALFREPLVYGSSRACQPWRCQSGPAVVATTEKAHHAKTTKPQAQPERRKPKTGILMLNMGGPETLGEVQDFLQRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKMWTSKQGEGMVKLLDELSPDTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNEVGRKPTMKWSTIDRWPTHPLLIQCFADHILKELDHFPEEKRSEVVILFSAHSLPMSVVNRGDPYPQEVGATVHRVMEQLGYPNPYRLVWQSKVGPVPWLGPQTDEAIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAQKCGAENIRRAESLNGNPLFSKALADLVHSHIQSNKLCSTQLSLSCPLCVNPVCRKTKSFFTSQQL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0042440 (pigment metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009719 (response to endogenous stimulus), GO:0051716 (cellular response to stimulus), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0009410 (response to xenobiotic stimulus), GO:0046483 (heterocycle metabolic process), GO:0046148 (pigment biosynthetic process), GO:0009636 (response to toxic substance), GO:0071495 (cellular response to endogenous stimulus), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0042168 (heme metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0046685 (response to arsenic-containing substance), GO:0010035 (response to inorganic substance), GO:1901360 (organic cyclic compound metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0010038 (response to metal ion), GO:0097305 (response to alcohol), GO:1901362 (organic cyclic compound biosynthetic process), GO:1901654 (response to ketone), GO:0017085 (response to insecticide), GO:0071310 (cellular response to organic substance), GO:0019438 (aromatic compound biosynthetic process), GO:0051597 (response to methylmercury), GO:0048545 (response to steroid hormone), GO:0033013 (tetrapyrrole metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0032870 (cellular response to hormone stimulus), GO:0033993 (response to lipid), GO:0018130 (heterocycle biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0006783 (heme biosynthetic process), GO:0006778 (porphyrin-containing compound metabolic process), GO:1901655 (cellular response to ketone), GO:0033014 (tetrapyrrole biosynthetic process), GO:0071548 (response to dexamethasone), GO:0045471 (response to ethanol), GO:0031960 (response to corticosteroid), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0071383 (cellular response to steroid hormone stimulus), GO:0010288 (response to lead ion), GO:0051384 (response to glucocorticoid), GO:0006779 (porphyrin-containing compound biosynthetic process), GO:0071384 (cellular response to corticosteroid stimulus), GO:0071549 (cellular response to dexamethasone stimulus), GO:0071385 (cellular response to glucocorticoid stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)