Protein: Glutamate receptor (A0A8M6Z4D2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system
Subcellular location: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR015683: Ionotropic glutamate receptor (family) [33-836]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [16-386]
- IPR001828: Receptor, ligand binding region (domain) [35-376]
- IPR001320: Ionotropic glutamate receptor, C-terminal (domain) [410-821]
- IPR019594: Ionotropic glutamate receptor, L-glutamate and glycine-binding domain (domain) [410-524]
- IPR001508: Ionotropic glutamate receptor, metazoa (family) [454-834]
Sequence:
MRILVLIPLLWGLGEGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNATEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLVTPSFPAEGETQFVLQLRPSIRGALLSLLDHYDWSRFVFLYDTDRGYAVLQAIMEKAGQNGWQVSAICVENFNDASYRRLLEDLDRRQEKKFVIDLEAERLQNILEQIVSVGKHVKGYHYIVANLGFKDISLERFMHGGANVTGFQLVDFSKPMVIKLMQRWNKLDQREYPGSESPPRYTSSLTYDGVLVMAEAFRNLRRQKIDISRRGNAGDCLANPAAPWNQGIDMERTLKQVRIQGLTGNIQFDHYGRRVNYTMDVFELKSNGPRKIGYWNDLDKLVLVQNELSMGNDSAMENRTVIVTTIMEGPYVMLKKNWEMYEGNEQFEGYCVDLASEIAKHIGIKYKISIVPDGKYGARDPETKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEEGSDGPPSDQPPNEFGIFNSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLAMLVALVEFCYKSRAEAKKLKVESAELNFSPAPSPTHSVQNLATYREGYNVYGSDAVKI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0030594 (neurotransmitter receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0099528 (G protein-coupled neurotransmitter receptor activity), GO:0015464 (acetylcholine receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0098960 (postsynaptic neurotransmitter receptor activity), GO:0016907 (G protein-coupled acetylcholine receptor activity), GO:0008227 (G protein-coupled amine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:1904888 (cranial skeletal system development), GO:0048863 (stem cell differentiation), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0048882 (lateral line development), GO:0048864 (stem cell development), GO:0007399 (nervous system development), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0048880 (sensory system development), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0014033 (neural crest cell differentiation), GO:0048925 (lateral line system development), GO:0043009 (chordate embryonic development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0014032 (neural crest cell development), GO:0048706 (embryonic skeletal system development), GO:0048881 (mechanosensory lateral line system development), GO:0048915 (posterior lateral line system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0036477 (somatodendritic compartment), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0097447 (dendritic tree), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0030425 (dendrite), GO:0043005 (neuron projection)