Protein: Dystrophin (A0A8M9PJA8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May play a role in anchoring the cytoskeleton to the plasma membrane
Subcellular location: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Membrane. Postsynaptic cell membrane. Synaptic cell membrane
InterPro domains:
- IPR035436: Dystrophin/utrophin (family) [4-3579]
- IPR043145: Zinc finger, ZZ-type superfamily (homologous_superfamily) [3208-3268]
- IPR002017: Spectrin repeat (repeat) [359-2946]
- IPR018159: Spectrin/alpha-actinin (repeat) [359-2947]
- IPR015154: EF-hand domain, type 2 (domain) [3118-3209]
- IPR011992: EF-hand domain pair (homologous_superfamily) [2992-3213]
- IPR015153: EF-hand domain, type 1 (domain) [2997-3114]
- IPR036872: CH domain superfamily (homologous_superfamily) [7-263]
- IPR050774: KCMF1 and Dystrophin (family) [2913-3577]
- IPR001202: WW domain (domain) [2962-2995]
- IPR001589: Actinin-type actin-binding domain, conserved site (conserved_site) [34-132]
- IPR000433: Zinc finger, ZZ-type (domain) [3214-3271]
- IPR001715: Calponin homology domain (domain) [32-257]
- IPR036020: WW domain superfamily (homologous_superfamily) [2956-2991]
Sequence:
MAEAVNPQDQWEEGFEDEFGEIIKTRSDEREDVQKKTFTKWINSQFAKTRRPPIDDLFTDLCDGRRLLELLEVLVGHEIVKERGFTRVHSLNNVNRALQILQKNNVDLVNIGGADIVDGNHKLTLGLIWSIILHWQVKDVMKDVMADLQQTNSEKILLSWVRQSLKNYQDVNVVNFSSSWADGFAFNALIHSHRPELFSWSVVEQQDNAIERLDHAFGVAEKSLGIDRLLDPEDVATVHPDKKSIIMYVTSLFKVLPHGVSLEAIQEVETLPRAAVTKEEHVLYQTQQRYSQQITVSVAQSRVRSPSPSYKPRFKSYAFTQAAYVKTPEQQRKFLIAQSPDKADELRPSPSPLPQGLNELESYQSALEEVLTWLLSAEDGLQAQPPISSFVEEVKEQFHTHEGYMVELTSHQGSVGRVLKAGSVLLSGGQLTDDEEREVREQMNLLNSRWEHLRVASMERQSRLHEVLMDLQHQQLKQLSDWLDTTETRIKRMGAQALGPELDDIKRQIEEQKLLQEDLELEQVRVNSLTHMVVVVDENSGDGATAALEEKLQNLGERWAAICKWTEERWILLQKILLCWQHFSEEQLLFDSWLTQKEELVQSIQSSGTNDPNEVAANLRKLAILKADLELKRQTMDKLCSLVQDLLTNIKSKEAAGKLEAKLERFAQRWDKLVQALQLTSTKISTIVTTSQSEITHTTMATVTKVTTNQKKMVKHTKEGMSTPPPQKKRQIVVDSELRKRFDVDFTEIHSFMTRSEAVLQNPEFSISRKEGSVADLYEKVLAIDREKPEKFRKLQEATRSAQALVDQLTSDGQNSEDIQQAAQQLRARWVDFCALLAERLAWLAYQTKVLAFYNLFQQLEQAAATAENWLKVQSPPACEPEPLRIQLERCRDEISRLSALQPQVAKLHEQLEELRQKEETPVLFDADISAFQEHYHQVLEDLRARERQLVLVQSSLPPARYKDVMAALLAWLQQCENKLAIPSTAVTEYPVMEQRLKDIKAIQASQKEHQGDVDDLNKMAEQVFQKAPPEICQKYRTELDNVMVRWRRISEQLEENIQKLQDHMTKLQQFQNDTKTLQKWMAEVDVFLNEEWPALGDAEALEKQLEQCTALVNDIHTVQPSLNGINEVGLALKREAETPFAIKIQKMLDELNAQWELICKQAYAKKSALKGGLDMTVSLRKEMQEMQEWITQAEEEYLERDFQYKTPEELHKAVEELKRAQEEVHQKETKVKLLTDKVTNFISKAPPAAHDALKAELDVLTSNYQRLCSRLDGKCKTLEEVWACWCELLSYLELENAWMDLLEKKLDETEGLQGGIEEIEEALTSLDTMIREHPEYNRNQIRELAQTLMDGRVLDELIHKKVEDYNTRWDELMQRASQRRQQLEKSLHWAQENDKTLRLIQDSLNTTDRHLTAYIADGIDAAQIPQEAQKIQTELNGHEVTLDDMKKKAMEVDASEKVIGEIDATLDKLLQVKGKFRLFQKPANFDQRLRECERVLEEVKVKLGVLSIRSVEQEVVQSQLEQCMKFYKNLSEVKSEVETVIKTGRQIVQKQQTEQPKELDDRLTALKLAYNDLGSQVTEGKQELEKILKLLRKFRKEVNSLTEWLATTDGELTRRSSVEGMPSDLDAELAWAKAAQEDTEHHKPQLKLVRELAGTLKGLLHSQENLIDDKVSLLNCNWIAVTSRSEQWLKLLLDYQNQMKTLEQNISQINTWMDRAEEKLDEMDSQGCIEHVIKGLRMELEEMKGKVEAVQVLAEDLIKNTGEHCKAQVKPKLEQLNQRFDIVARRILMGQASSQELDEYHRQANIWLQVLDEEIKLGESLKEEDFLEDATIDEEALNELFLKGENLLKRTPGGEKREAVREKHNLLHDRYDTLKNLRALRKKKALALASQWYQFCKKSDDMMQWLDRIEKSIRELPDPPEEPRVKAVGYEIDQQRPKLEDLRGLGRVLSEGGASRMVEPRLLPINKRWTELDVNFTRVRHKSELQFLLQCISENEALLNSPERWSTAFINLPQQEKCLKEVKVNLDKLEGPVAEAVGRGASQPEEGLLVQLLRTNWENLKMLYQDRLKRLEKAKKFNEELKMLDNWLTDAERTIMKYEQDPINNRDHLKELQAGLEKQEAAVKGLNALGTDLSPQCSKDDRDHIKQQLASINSRWAKVSNQLTEIKRRSAGAKMLLAELNEDMGEFQSWLDDAEAVAALPVEAGRKEQLSATLEKVKARVVELPSRKQALHQINSKGSSLPADKVKPLEKQLKVINMRWAKVSTDLPEKQRQIEDLLRDLSLYQEQLSKLSIWASNTKTQLEQSPTAVDPKIEDDVKEKKPAVETLLAKERPPCQPEKGQYDGLSADWTSIQVLLKDWKDKCQLAAVTLTGSAAGDAALDKFNKSWTELDDWLALLDHMVQTQRVMVGDLDEINEMTVKLKSALQDMEQRCPQLNKQITAAQNLKNKTNNPETRATITDRIEKLQAHWEDSHAKLTARVLTLQNMYKDSSDWLEARKRVEPLIKKANEKLESWKKVSHSVEDLKGQNADVKQLSKDLQQWQTQMNVTNELANKLLTLYADDDTSKVKQMTESMNLAWANIKKRAGDKEADLEAGLRQLQHYYLDLEKFLNWLTEAETTANVLQDATFKEGLLENPATVRHLLEQWQDLQAEIDAHRETYHSLDENGHRIVSSLEGTDNAVVLQKRLDDMGQRWHELCNKVMSIRPYLDAGVDQWKHLHMSLQELLNWLQLKREELEKQKPVGGDVPTVHQQLLTHKAFRRELGAKEPVINGTLDNAKTFLAEMPREGLKQRPGQKDVSPEERVQNVGRILRKEVEDVTVRWKNLGAASVDWQQQLELALERLMELQDAQDQLDYKLRQAESVKNSWKPVGELLVDDLQNHIDRVKAFQEEIAPIQDNVNHVNQLASTFRPSDIQLSPDNLSRIDDLNMRWRLLQISIEEHLSQLTTAFKDLGPSQNFLHASVESPLERSISPNNVPYYINHQTQTTCWDHPKMAELYQSLADLNNVRFSAYRTAMKLRRMQKALCLDLLSMPAACEAFEQHNLKQNEQFMDIVQVINCLTSIYDRLEQQHSSLVNVPLCVDMCLNWLLNVYDTGRAGKIRTLSFKTGIISLCKAHLEDKYRFLFREVASATGFCDQRRLGLLLHDAIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPELEASVFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMQYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTILEGDNMETPVTLINFWPVDHPPASSPQLSHDDTHSRIEHYASRLAEMENRNGSYVNDNVSPNESMDDEHLLIQHYCQSLNQGSPLSQPQSPAQILISMETEEKGELERVLNDLEQENRKLQAEYDRLKKAHDHKGLSPLPSPPQMLPVSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLTRLRQLLEQPQTESKVNGTALSSPSTASPRSDTSLASLRVAASQTTETMGDDELSSPTQDASTGLEDVIEQLNNSFPHSQGGGRLNP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0050998 (nitric-oxide synthase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0016203 (muscle attachment), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0003008 (system process), GO:0032989 (cellular component morphogenesis), GO:0003012 (muscle system process), GO:0061061 (muscle structure development), GO:0044085 (cellular component biogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0042692 (muscle cell differentiation), GO:0055001 (muscle cell development), GO:0060537 (muscle tissue development), GO:0006936 (muscle contraction), GO:0061053 (somite development), GO:0007517 (muscle organ development), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0031032 (actomyosin structure organization), GO:0030239 (myofibril assembly), GO:0007525 (somatic muscle development), GO:0097435 (supramolecular fiber organization), GO:0022607 (cellular component assembly), GO:0007519 (skeletal muscle tissue development), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0051146 (striated muscle cell differentiation), GO:0060538 (skeletal muscle organ development), GO:0014904 (myotube cell development), GO:0055002 (striated muscle cell development), GO:0045214 (sarcomere organization), GO:0140694 (non-membrane-bounded organelle assembly), GO:0014902 (myotube differentiation), GO:0048741 (skeletal muscle fiber development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane), GO:0042383 (sarcolemma)