Protein: Endothelial PAS domain-containing protein 1 isoform X1 (A0A8N7UR89)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
- IPR021537: Hypoxia-inducible factor, alpha subunit-like (domain) [522-554]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [12-68]
- IPR001067: Nuclear translocator (family) [49-259]
- IPR001610: PAC motif (repeat) [303-346]
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [5-75]
- IPR000014: PAS domain (domain) [86-339]
- IPR013655: PAS fold-3 (domain) [253-340]
- IPR013767: PAS fold (domain) [92-148]
- IPR035965: PAS domain superfamily (homologous_superfamily) [95-343]
- IPR014887: HIF-1 alpha, C-terminal transactivation domain (domain) [807-842]
Sequence:
MTAEREKKRHPSERRKEKSRDAARCRRSKETEVFYELAHQLPLPHSISSHLDKASIMRLAISFLRTRKLFSSGHTVQQMRSQNLGQMDNLYLKSLEGFVIVVTSDGDMIFLSENVSKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSIKSGPVYGRKGKEMSTSRDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLQVCSSRPPQILCGFSEPPLTCITMLCAPIPHPSNVDTPLDSKTFMSRHSMDMKFIYCDERVSSLIGYRPEELLGRSVYEFCHALDSENMTKSHQNLCNKGQVVSGQYRMLAKNGGYVWVETQATVIYNNRNSQPQCIICINYILSSVEEQSVIFSLDQTEALFKPYHTYDMGEIFSQNTSISEPQNNLFTTLKEEPEELAQLAPMPGDAIIALDFERAEFEEATFFSKSSKLPAVGPSWVVDTPPDGSPERNLSSLPSSFTVPQVPPAGKCTPCTTPCLSSCSSCSTPNSPVDCCGSGEWDLKVELTEKLFAPESGATNPTDSQLNLSDLDLETLAPYIPMDGEDFQLHPICLEEPVPDAGPGLSAAVQHSFSSVADLFQPLGQYPPYIKNRPSTCPDSTHIQPYQTTPNIPLSSEKQRQSLHWPPDQLSQYENTNVGCMDDRNTGGPGQTCNFNVPPPHQRFFENFTPVQKGMSLGQRALLNNFKRKRQSEFPLSCSFSDIPKQVVAPHKSTDGMRKRMKPMNDDSCAFSVRKSLSTSVLTDKFPCMQSGLVDPQACSRSVKGCPEDLKQHCTDSFCSNSSRQYNMMPSRKHTGMISQLLAPSFDSYCLPELTRYDCEVNMPLQGNLHLLQGSDLLRALDQST
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis), GO:0048863 (stem cell differentiation), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0007219 (Notch signaling pathway), GO:0060218 (hematopoietic stem cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)