Protein: Sodium channel protein (A0A8M9Q653)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR024583: Voltage-gated Na+ ion channel, cytoplasmic domain (domain) [543-692]
- IPR005821: Ion transport domain (domain) [129-1777]
- IPR010526: Sodium ion transport-associated domain (domain) [980-1193]
- IPR043203: Voltage-gated cation channel calcium and sodium (family) [46-1988]
- IPR058542: SCN5A-like, C-terminal IQ motif (domain) [1889-1922]
- IPR001696: Voltage gated sodium channel, alpha subunit (family) [1749-1797]
- IPR044564: Voltage-gated sodium channel alpha subunit, inactivation gate (domain) [1465-1517]
- IPR027359: Voltage-dependent channel domain superfamily (homologous_superfamily) [123-1634]
Sequence:
MAAQLLVPPGPDSFRPFLPESLAAIEQRIAEEVAQRPKGERRPDDDDENGPKPNRDLEAGKPLPFIYGDVPPHMLSVPLEDLDTYYSNQKTFIVLNRGKAIFRFNATPALYILSPFNPLRRISIRVLVHSLFSFVIMCTILTNCAFMTLSNPPEWAKNVEYTFTGIYTFESLIKILARGFCVGKFTFLRDPWNWLDFSVILMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRQKCVKMPEVNVTDNLTDYSTELHNSTFNWTEYISDSNNYYFIPGRRDALLCGNSSDAGQCPEGFTCIKAGRNPDYGYTSFDTFSWAFLSLFRLMTQDFWENLYQQTLRAAGKPYMIFFVLVIFLGSFYLVNLILAVVAMAYDEQNQATIEEAQQKEEEFQAMLEQLKRQQEEAQVAAAAATESGEYSGRGGLSEESSSGGSRLSSKSAKERRNRRKKRKQREEEEKADQEKFHKSASEDSIRRPGFRFSIDANRLSYEKKCSTPNQSLLSIRGSLFSPRRNSRASLFSFRGRARDFGSENDFADDEHSTFEDSDSRRGSLFVPRCVERRSSTVSHCSLTAPRIMLPANGKMHCTVDCNGVVSLVGGTSVPTSPIGRLLPEGTTTESDVRKKRSGSHQPSDYLEETVARKRAMSVASILTNTMEELEESRQKCPPCWYKFANSFLIWDCSPAWLKVKEIMNMIVMDPFVDLAITICIVLNTLFMAMEHYPMTTQFSHLLSVGNLVFTGIFTAEMCLKVIALDPYYYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYRECVCKISESCELPRWHMDDFFHSFLIVFRVLCGEWIETMWDCMEVAGQSMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDSEMNNLQIAVGRIQKGIALVKSTLRQFLQSLFLAGSKPRSLDEEKPLDDLHSDGKENCLSNHAPVAVDLTKDYLKEGCVSPGNGVESHVKYGIEEGDYMSFIHNPSLTVTVPIAVGESDFENLNTEDFSSESSDVEGSKEKLPVDTVLSSSEGSTVDIRPPGEGAESVELEPEESLDPEACFTEGCVMRFQCCQVDVEKGKWKSWWILRKTCFIIVEHNWFESFIIFMILLSSGALAFEDIYIEQRKTIKTVLEYADKVFTYIFILEMLLKWVAYGFAKYFTNAWCWLDFLIVDVSLVSLVANALGYSELSAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYYYCVNITNDELFPVSVVNNKSDCYALIQNNDTARWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDLEQQPVYETNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGLVFDLITKQAFDIIIMILICLNMVTMMVETDDQTEDMDNILYWINLVFIILFTGECVLKMISLRHYFFTIGWNVFDFVVVILSIVGMFLSEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREAGIDDMFNFETFGNSMLCLFQITTSAGWDGLLAPILNKQDPDCDSEMEHPGSFYRGNCGNPSVGIFFFVSYIIICFLIVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWERFDPNATQFVEYNKLSDFADALDPPLRIAKPNKIQLIAMDLPMVSGDRIHCLDILFAFTLRVLGEEGEMDALRGQMEDRFMASNPSKVSYEPITTTLRRKQEEMSAVVIQRAFRRHRIRQTVKKASEAYRKQLQDGGGHIPEKEVLVIGKFQENSASDKTDMTPSSASPPSYNSVAKSEKDKYEKERREKEDKAKDARDRKK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005272 (sodium channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005248 (voltage-gated sodium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0042752 (regulation of circadian rhythm), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0003008 (system process), GO:0007154 (cell communication), GO:0007610 (behavior), GO:0009894 (regulation of catabolic process), GO:0099536 (synaptic signaling), GO:0019226 (transmission of nerve impulse), GO:0042391 (regulation of membrane potential), GO:0062012 (regulation of small molecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0050877 (nervous system process), GO:1904059 (regulation of locomotor rhythm), GO:0080090 (regulation of primary metabolic process), GO:0050795 (regulation of behavior), GO:0007626 (locomotory behavior), GO:0006140 (regulation of nucleotide metabolic process), GO:0043467 (regulation of generation of precursor metabolites and energy), GO:0043470 (regulation of carbohydrate catabolic process), GO:0036269 (swimming behavior), GO:0019228 (neuronal action potential), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0006109 (regulation of carbohydrate metabolic process), GO:0001508 (action potential), GO:0051174 (regulation of phosphorus metabolic process), GO:1900542 (regulation of purine nucleotide metabolic process), GO:0006110 (regulation of glycolytic process), GO:0043457 (regulation of cellular respiration), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:1903578 (regulation of ATP metabolic process), GO:1903715 (regulation of aerobic respiration), GO:0002082 (regulation of oxidative phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0001518 (voltage-gated sodium channel complex), GO:0034703 (cation channel complex), GO:0034706 (sodium channel complex)