Protein: Glycogen debranching enzyme (Q59MN2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation
Subcellular location: Cytoplasm
InterPro domains:
- IPR032790: Glycogen debranching enzyme, C-terminal (domain) [1040-1514]
- IPR006421: Glycogen debranching enzyme, metazoa (family) [36-1520]
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [127-737]
- IPR010401: Glycogen debranching enzyme (family) [46-1522]
- IPR029436: Eukaryotic glycogen debranching enzyme, N-terminal domain (domain) [48-136]
- IPR012341: Six-hairpin glycosidase-like superfamily (homologous_superfamily) [1024-1521]
- IPR032788: Glycogen debranching enzyme, central domain (domain) [723-966]
- IPR032792: Glycogen debranching enzyme, glucanotransferase domain (domain) [124-596]
- IPR008928: Six-hairpin glycosidase superfamily (homologous_superfamily) [1057-1522]
Sequence:
MSEARTVLFRLSNLGEPVNNENIANGVLILPVVELPSNYKPGDALFQLRFQLNAASKVSRNGTLYTNVPSKYEQDFDRNTHYQYPIKSSFHEDITITVPIYKPGSYNYYIEYDDEEDNKKTTEKYYFNVPPNLTINGKFVPFNNINVETVVSKWIGPYENWDKFFKIVAQKGYNMIHFTPLQERGESDSPYSIYDQLKFDPKIFPGSDKDAIQKIHKVLNDNQLLSLTDVVWNHTANNSEWLREHPDSGYNATTAPHLIPAIELDEALLEFSHSLQELGLPTVLESEADLQKVMDGIQTHVLDKLKLWEYYVFNKRQTIVDLEKSFNDNKNNINKIQIPNDVDSQDLKQLSDYVLKVANINPTPIIGDRFANKLNVDKFLGVLFTVFDNNVEFETIANRAEEIIDEINSDLYAAFDDDTNSIKQQVADRIKYLRLADNGPKLGEITDKSPLTEPYFTRFTDVNGKKQALANNGWIWGGNPLVDFASNKSKAYIRREVIVWGDCVKLRYGEKFEDSPETWKRMIEYTQLSAKTFNGFRIDNCHSTPLHVGERLLDEARKVNPNLYVIAELFSGSEEMDKIFVERLGINSLIREAMQAWSVGELSRLVHKHGGRPIGSLTWLPLDDFTYPAANEPVKDKFIDGYTELEIPKVLTCQAPHAIFMDCTHDNEMPAQKRTVEDTLPNAALVAFCSSAIGSVFGYDECYPKLLNVVSETRHYDLDSDNGIGKVKAKLNKIRDDLVQESEDVTRDHEMYIHHEGQYITIQRYNARTGNGWFLIARSKFSDHESAQGLSPSILGGTKVKHQFSYSLIRQPGDYESQQDKLTGIPVQVEAIQSPSIEYTDDGDSIITIDEASFIPGSIAVFSTEIPGVDVKLDNFVKQGAIEASIGLDLYDLNALLYRASTEELDASNGKDDVYDIPGYGRLTYAGLEGWNTALKHVIWQNNLGHAICDHLRNGDWAFDYVVNRLDKYAAKSENLSKFQDWLRSRFDAVKKSKAPYFLRPHYFALIMGIAYEAARFRVIRQMSDGIKVATNFVQSLALTSVQMVGYMQNTSLVPDKQVPCMAAGLPHFSNDYMRCWGRDVFIAFRGLLIVTGRYDDAKQHILGFAKTLKHGLIPNLLDAGRNPRYNARDAAWFFLQAIQEYVTYAPNGIDILDEKVTRRFPLDDTYIPVDDPQAFSYESSIREIIYEILSRHAKGIKYREANAGPNLDSQMRDEGFNVEVGVDWTNGLIYGGNQFNCGTWMDKMGESEKAHNKGIPGTPRDGSAIEIQGLLKSALRFVNKLHKQGKFEYTKVTKPDGSTISLEDWESLLAENFEKHYYVPKDPQQDDQYVIDPSIVNRRGIYKDLYNSGKPFEDYQLRPNFAIAMCVAPELFTPEKALGAIIIADKAIRGPIGMRTLDPSDWNYRPYYENSIDNDDFATSKGRNYHQGPEWVWNTGYFLRAFLLFHHLEEESSKASSSSPSIKILTLLNDRLQGHIKWIKESPWNGLTELTNKDGSYCQDSSPTQAWSGSCLLDLYYDLWNDKHFQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0016757 (glycosyltransferase activity), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0016758 (hexosyltransferase activity), GO:0015926 (glucosidase activity), GO:0090599 (alpha-glucosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0044248 (cellular catabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0044275 (cellular carbohydrate catabolic process), GO:0009057 (macromolecule catabolic process), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0016052 (carbohydrate catabolic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0005976 (polysaccharide metabolic process), GO:0006112 (energy reserve metabolic process), GO:0000272 (polysaccharide catabolic process), GO:0044042 (glucan metabolic process), GO:0044247 (cellular polysaccharide catabolic process), GO:0006073 (cellular glucan metabolic process), GO:0009251 (glucan catabolic process), GO:0005977 (glycogen metabolic process), GO:0005980 (glycogen catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0019898 (extrinsic component of membrane), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0009897 (external side of plasma membrane), GO:0019897 (extrinsic component of plasma membrane), GO:0043229 (intracellular organelle), GO:0098562 (cytoplasmic side of membrane), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0009898 (cytoplasmic side of plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)