Protein: Rho GTPase activating protein 4, isoform CRA_a (A6KRU0)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [26-348]
- IPR001452: SH3 domain (domain) [755-814]
- IPR000198: Rho GTPase-activating protein domain (domain) [516-704]
- IPR051627: SLIT-ROBO Rho GTPase-activating (family) [5-953]
- IPR031160: F-BAR domain (domain) [21-325]
- IPR008936: Rho GTPase activation protein (homologous_superfamily) [456-711]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [757-827]
- IPR001060: FCH domain (domain) [22-125]
Sequence:
MAAHGKLRRERGLQPEYEAQVKVMRGQLSEQLHCLELQGELRRDLLLELAEFMRRRAEVELEYSRGLDKLAERFTSRSGRLGGSSREQQSFRKEPTLLSPLHCWAMLLEHTRQQSRESATLSEVLAGPLAQRLSHIAEDVGRIVKKSKDLVQQLQDELLEVVSELQTTKKTYHVYHLESMNAETKLREAERQEEKRSGKSALPTTTAASATTTITIETELHRKGSLKKGGRLVEKRQAKFLEHKLKCTKARNEYLLSLASVNAAVSNYYLHDILDLMDCCDTGFHLALEQALRSYTAAESRTQTSHMQGLGSLEEALEALDPPGDKAKVLEVHAMAFCPPLRFDYQPHEGDEVAEIQVEMELRDEILPRAQNIQSRLDQKTIETEEVNKTLKATLQALLEVVASEDGDILDSLQASPSTESLKSTSSDPGTRQAGRRRNQQQETETFYITKLQEYLSGRSILAKLQAKHEKLQEAIQRGNKEEQETSSWTQCTERKFHKSHHPYPGSQCTQRLFGGDLEKFIQSTGQPVPLVVKSCIRFINLNGLQHEGIFRVSGAQARILEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPLDMFNELLASAELEVVGERVELVSHLLSRLPRPVLVVLRYLFTFLNHLAQYSDENMMDSYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLILQPAWVFPPTAMLPGPIYEKCMAPPSASCLGDGQLESLAGEPELELKTGTKAQEDDSEGVVEAVACFAYTGRTAQELTFQQGDTLRLYARASSDWWRGEHAGVRGLIPHKYITLSEGDEKQMTGSGLQAMGESLSHPESVLTLEFTNRLELGTPPEALGPSGHRRHCLVPTSPEQHVEMDKAVAQNMDSVFKELLGKAAVRQGHGLASTASPSLGTRNLKPLACSSFSKNKVFSRGPGAPVSPSVSHPQGPDSTRKPV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0040013 (negative regulation of locomotion), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0045926 (negative regulation of growth), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0040008 (regulation of growth), GO:0040012 (regulation of locomotion), GO:2000026 (regulation of multicellular organismal development), GO:0051129 (negative regulation of cellular component organization), GO:2000145 (regulation of cell motility), GO:2000146 (negative regulation of cell motility), GO:0051961 (negative regulation of nervous system development), GO:0045596 (negative regulation of cell differentiation), GO:0048640 (negative regulation of developmental growth), GO:0048731 (system development), GO:0001558 (regulation of cell growth), GO:0030308 (negative regulation of cell growth), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0061387 (regulation of extent of cell growth), GO:0032535 (regulation of cellular component size), GO:0050770 (regulation of axonogenesis), GO:0050768 (negative regulation of neurogenesis), GO:0007399 (nervous system development), GO:0031344 (regulation of cell projection organization), GO:0060284 (regulation of cell development), GO:0030516 (regulation of axon extension), GO:0030517 (negative regulation of axon extension), GO:0051960 (regulation of nervous system development), GO:0030334 (regulation of cell migration), GO:0031345 (negative regulation of cell projection organization), GO:0010721 (negative regulation of cell development), GO:0030336 (negative regulation of cell migration), GO:0050771 (negative regulation of axonogenesis), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0010977 (negative regulation of neuron projection development), GO:0050767 (regulation of neurogenesis), GO:0010762 (regulation of fibroblast migration), GO:0008361 (regulation of cell size), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0030427 (site of polarized growth), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0005794 (Golgi apparatus), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0030426 (growth cone), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0030424 (axon), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)