Protein: Tyrosine-protein kinase (A6IVF7)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [404-525]
- IPR001849: Pleckstrin homology domain (domain) [3-137]
- IPR001452: SH3 domain (domain) [216-276]
- IPR050198: Non-receptor tyrosine kinases involved in cell signaling (family) [222-525]
- IPR000719: Protein kinase domain (domain) [404-527]
- IPR000980: SH2 domain (domain) [281-379]
- IPR035574: Tyrosine-protein kinase BTK, SH3 domain (domain) [219-273]
- IPR001562: Zinc finger, Btk motif (conserved_site) [126-173]
- IPR017441: Protein kinase, ATP binding site (binding_site) [410-432]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [207-276]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [253-391]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [385-524]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [2-172]
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPVPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPTAAPISTSELKKVVALYDYMPMNANDLQLRKGEEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGEPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLVCS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004713 (protein tyrosine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0008283 (cell population proliferation), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0048871 (multicellular organismal-level homeostasis), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0002683 (negative regulation of immune system process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0001776 (leukocyte homeostasis), GO:0002532 (production of molecular mediator involved in inflammatory response), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0051640 (organelle localization), GO:0001775 (cell activation), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0140029 (exocytic process), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0002252 (immune effector process), GO:0006950 (response to stress), GO:0140352 (export from cell), GO:0002262 (myeloid cell homeostasis), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0002695 (negative regulation of leukocyte activation), GO:0032103 (positive regulation of response to external stimulus), GO:0043207 (response to external biotic stimulus), GO:0002366 (leukocyte activation involved in immune response), GO:0080134 (regulation of response to stress), GO:0044248 (cellular catabolic process), GO:0050766 (positive regulation of phagocytosis), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0002694 (regulation of leukocyte activation), GO:0060627 (regulation of vesicle-mediated transport), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0001817 (regulation of cytokine production), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0050866 (negative regulation of cell activation), GO:0070661 (leukocyte proliferation), GO:0051656 (establishment of organelle localization), GO:1990849 (vacuolar localization), GO:0002697 (regulation of immune effector process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0050778 (positive regulation of immune response), GO:0032940 (secretion by cell), GO:0002443 (leukocyte mediated immunity), GO:0001819 (positive regulation of cytokine production), GO:0031349 (positive regulation of defense response), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0050865 (regulation of cell activation), GO:0009620 (response to fungus), GO:0008284 (positive regulation of cell population proliferation), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0006979 (response to oxidative stress), GO:0019538 (protein metabolic process), GO:0008285 (negative regulation of cell population proliferation), GO:0006952 (defense response), GO:0051649 (establishment of localization in cell), GO:1901700 (response to oxygen-containing compound), GO:0010817 (regulation of hormone levels), GO:0010033 (response to organic substance), GO:0071216 (cellular response to biotic stimulus), GO:0043170 (macromolecule metabolic process), GO:0043299 (leukocyte degranulation), GO:0050867 (positive regulation of cell activation), GO:0048872 (homeostasis of number of cells), GO:0002696 (positive regulation of leukocyte activation), GO:0050776 (regulation of immune response), GO:0042127 (regulation of cell population proliferation), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0002702 (positive regulation of production of molecular mediator of immune response), GO:0009617 (response to bacterium), GO:0006810 (transport), GO:0002263 (cell activation involved in immune response), GO:0001780 (neutrophil homeostasis), GO:0001818 (negative regulation of cytokine production), GO:0002274 (myeloid leukocyte activation), GO:0002699 (positive regulation of immune effector process), GO:0023061 (signal release), GO:0034599 (cellular response to oxidative stress), GO:1903555 (regulation of tumor necrosis factor superfamily cytokine production), GO:0031347 (regulation of defense response), GO:0002238 (response to molecule of fungal origin), GO:0032418 (lysosome localization), GO:0071705 (nitrogen compound transport), GO:0002703 (regulation of leukocyte mediated immunity), GO:0002863 (positive regulation of inflammatory response to antigenic stimulus), GO:0030163 (protein catabolic process), GO:0002237 (response to molecule of bacterial origin), GO:0071702 (organic substance transport), GO:0032675 (regulation of interleukin-6 production), GO:0002705 (positive regulation of leukocyte mediated immunity), GO:0070663 (regulation of leukocyte proliferation), GO:0050678 (regulation of epithelial cell proliferation), GO:0002639 (positive regulation of immunoglobulin production), GO:0051250 (negative regulation of lymphocyte activation), GO:0010468 (regulation of gene expression), GO:0009057 (macromolecule catabolic process), GO:0043412 (macromolecule modification), GO:0006887 (exocytosis), GO:0051251 (positive regulation of lymphocyte activation), GO:0009100 (glycoprotein metabolic process), GO:0050729 (positive regulation of inflammatory response), GO:0002444 (myeloid leukocyte mediated immunity), GO:0032740 (positive regulation of interleukin-17 production), GO:0070665 (positive regulation of leukocyte proliferation), GO:1901701 (cellular response to oxygen-containing compound), GO:0010629 (negative regulation of gene expression), GO:0002819 (regulation of adaptive immune response), GO:0051249 (regulation of lymphocyte activation), GO:0043303 (mast cell degranulation), GO:0032496 (response to lipopolysaccharide), GO:1901565 (organonitrogen compound catabolic process), GO:0062197 (cellular response to chemical stress), GO:1903557 (positive regulation of tumor necrosis factor superfamily cytokine production), GO:0009914 (hormone transport), GO:0032755 (positive regulation of interleukin-6 production), GO:0046903 (secretion), GO:0010628 (positive regulation of gene expression), GO:0006796 (phosphate-containing compound metabolic process), GO:0046879 (hormone secretion), GO:0050679 (positive regulation of epithelial cell proliferation), GO:0032660 (regulation of interleukin-17 production), GO:0032693 (negative regulation of interleukin-10 production), GO:0036211 (protein modification process), GO:0050764 (regulation of phagocytosis), GO:0006954 (inflammatory response), GO:0050727 (regulation of inflammatory response), GO:0045576 (mast cell activation), GO:1901136 (carbohydrate derivative catabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0033993 (response to lipid), GO:0002861 (regulation of inflammatory response to antigenic stimulus), GO:0070664 (negative regulation of leukocyte proliferation), GO:0002821 (positive regulation of adaptive immune response), GO:0032653 (regulation of interleukin-10 production), GO:0016192 (vesicle-mediated transport), GO:0002275 (myeloid cell activation involved in immune response), GO:0002637 (regulation of immunoglobulin production), GO:0000302 (response to reactive oxygen species), GO:0050670 (regulation of lymphocyte proliferation), GO:0002822 (regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0006029 (proteoglycan metabolic process), GO:0032944 (regulation of mononuclear cell proliferation), GO:0001821 (histamine secretion), GO:0018193 (peptidyl-amino acid modification), GO:0050671 (positive regulation of lymphocyte proliferation), GO:0016310 (phosphorylation), GO:0002888 (positive regulation of myeloid leukocyte mediated immunity), GO:0032946 (positive regulation of mononuclear cell proliferation), GO:0050869 (negative regulation of B cell activation), GO:0002448 (mast cell mediated immunity), GO:0002886 (regulation of myeloid leukocyte mediated immunity), GO:0002675 (positive regulation of acute inflammatory response), GO:0034614 (cellular response to reactive oxygen species), GO:0050864 (regulation of B cell activation), GO:0045055 (regulated exocytosis), GO:0002864 (regulation of acute inflammatory response to antigenic stimulus), GO:0050871 (positive regulation of B cell activation), GO:0006516 (glycoprotein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm)