Protein: Toll-like receptor 9 (A6I2Q1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasmic vesicle, phagosome. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR035897: Toll/interleukin-1 receptor homology (TIR) domain superfamily (homologous_superfamily) [863-1017]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [122-748]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [24-823]
- IPR000157: Toll/interleukin-1 receptor homology (TIR) domain (domain) [868-1016]
- IPR001611: Leucine-rich repeat (repeat) [123-763]
- IPR041283: Leucine-rich repeat unit (repeat) [393-422]
Sequence:
MVLCRRTLHPLSLLVQAAMLAEALALGTLPAFLPCELKPHGLVDCNWLFLKSVPHFSAAEPRSNITSLSLIANRIHHLHNLDFVHLPNVRQLNLKWNCPPPGLSPLHFSCRMTIEPKTFLAMRMLEELNLSYNGITTVPRLPSSLTNLSLSHTNILVLDASSLAGLHSLRVLFMDGNCYYKNPCNGAVNVTPDAFLGLSNLTHLSLKYNNLTEVPRQLPSSLEYLLLSYNLIVKLGPEDLANLTSLRVLDVGGNCRRCDHAPDLCTECRQKSLDLHPQTFRHLSHLEGLVLKDSSLHSLNSKWFQGLVNLSVLDLSENFLYESINKTSAFQNLTRLRKLDLSFNYCKKVSFARLHLASSFKSLVSLQELNMNGIFFRLLNKNTLRWLAGLPKLHTLHLQMNFINQAQLSVFSTFRALRFVDLSNNRISGPPTLSRVAPEKADEAEKGVPWPASLTPALPSTPVSKNFMVRCKNLRFTMDLSRNNLVTIKPEMFVNLSHLQCLSLSHNCIAQAVNGSQFLPLTNLKVLDLSYNKLDLYHSKSFSELPQLQALDLSYNSQPFSMQGIGHNFSFLANLSRLQNLSLAHNDIHSRVSSRLYSTSVEYLDFSGNGVGRMWDEEDLYLYFFQDLRSLIHLDLSQNKLHILRPQNLNYLPKSLTKLSFRDNHLSFFNWSSLAFLPNLRDLDLAGNLLKALTNGTLPNGTLLQKLDVSSNSIVFVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMNLTVLDVSSNPLHCACGAPFVDLLLEVQTKVPGLANGVKCGSPRQLQGRSIFAQDLRLCLDDVLSRDCFGLSLLAVAVGTVLPLLQHLCGWDVWYCFHLCLAWLPLLTRGRRSAQALPYDAFVVFDKAQSAVADWVYNELRVRLEERRGRRALRLCLEDRDWLPGQTLFENLWASIYGSRKTLFVLAHTDKVSGLLRTSFLLAQQRLLEDRKDVVVLVILRPDAHRSRYVRLRQRLCRQSVLFWPHQPNGQGSFWAQLSTALTRDNHHFYNRNFCRGPTAE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0022414 (reproductive process), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0003006 (developmental process involved in reproduction), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0002253 (activation of immune response), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0002764 (immune response-regulating signaling pathway), GO:0032103 (positive regulation of response to external stimulus), GO:0043207 (response to external biotic stimulus), GO:0002269 (leukocyte activation involved in inflammatory response), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0006952 (defense response), GO:0032101 (regulation of response to external stimulus), GO:0048608 (reproductive structure development), GO:1901700 (response to oxygen-containing compound), GO:0045137 (development of primary sexual characteristics), GO:0061900 (glial cell activation), GO:0071216 (cellular response to biotic stimulus), GO:0010033 (response to organic substance), GO:0002218 (activation of innate immune response), GO:0098542 (defense response to other organism), GO:0009894 (regulation of catabolic process), GO:0002831 (regulation of response to biotic stimulus), GO:0010035 (response to inorganic substance), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0002833 (positive regulation of response to biotic stimulus), GO:0009617 (response to bacterium), GO:0050778 (positive regulation of immune response), GO:0031323 (regulation of cellular metabolic process), GO:0007548 (sex differentiation), GO:0002274 (myeloid leukocyte activation), GO:0031349 (positive regulation of defense response), GO:0046661 (male sex differentiation), GO:0009615 (response to virus), GO:0009896 (positive regulation of catabolic process), GO:0010038 (response to metal ion), GO:0031347 (regulation of defense response), GO:0061458 (reproductive system development), GO:0045089 (positive regulation of innate immune response), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:0002758 (innate immune response-activating signaling pathway), GO:0045088 (regulation of innate immune response), GO:0051607 (defense response to virus), GO:0071310 (cellular response to organic substance), GO:0042116 (macrophage activation), GO:0010506 (regulation of autophagy), GO:0008406 (gonad development), GO:0002237 (response to molecule of bacterial origin), GO:0046546 (development of primary male sexual characteristics), GO:0006954 (inflammatory response), GO:0140546 (defense response to symbiont), GO:0010508 (positive regulation of autophagy), GO:0071241 (cellular response to inorganic substance), GO:0033993 (response to lipid), GO:0031331 (positive regulation of cellular catabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0001774 (microglial cell activation), GO:1901701 (cellular response to oxygen-containing compound), GO:0071222 (cellular response to lipopolysaccharide), GO:0002221 (pattern recognition receptor signaling pathway), GO:0071396 (cellular response to lipid), GO:0071248 (cellular response to metal ion), GO:0008584 (male gonad development), GO:0150076 (neuroinflammatory response), GO:0002224 (toll-like receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)