Protein: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (A0A8M1PHN1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3
Subcellular location: Cell projection, dendritic spine. Cytoplasm. Nucleus. Nucleus, PML body. Postsynaptic density
InterPro domains:
- IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [2-188]
- IPR051281: Dual-specificity lipid and protein phosphatase (family) [2-428]
- IPR045101: PTEN, phosphatase domain (domain) [26-183]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [104-175]
- IPR029023: Tensin-type phosphatase domain (domain) [16-187]
- IPR014020: Tensin phosphatase, C2 domain (domain) [190-401]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [124-134]
- IPR017361: Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN (family) [2-454]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [25-185]
- IPR035892: C2 domain superfamily (homologous_superfamily) [193-400]
Sequence:
MAMTAKLKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDASKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRKKFAEAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNKLDYKPVALLFHKMVFQTLPMFSGGTCRDSTVKNRSEVNPQGFKKGSWHWDPQFVVYQLKVKIHTSNPAHTRREEKHMIFEFPQPLPVCGDIKVEFFHKQSKMMKKDKMFHFWINTFFIPGPEEAGDKVENGSVVNDVDSLSCQSQSSPAERDREKERAVAAAALDRERGGERADGEKDYLILTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNSEASTSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEEQHAQITKV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0042577 (lipid phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0006955 (immune response), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0002252 (immune effector process), GO:0044238 (primary metabolic process), GO:0006950 (response to stress), GO:0051093 (negative regulation of developmental process), GO:0009611 (response to wounding), GO:0001568 (blood vessel development), GO:0048468 (cell development), GO:0002366 (leukocyte activation involved in immune response), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0019637 (organophosphate metabolic process), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0044255 (cellular lipid metabolic process), GO:1901343 (negative regulation of vasculature development), GO:0006793 (phosphorus metabolic process), GO:0048840 (otolith development), GO:2000026 (regulation of multicellular organismal development), GO:0006629 (lipid metabolic process), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0033554 (cellular response to stress), GO:0002263 (cell activation involved in immune response), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0016043 (cellular component organization), GO:0002274 (myeloid leukocyte activation), GO:0048839 (inner ear development), GO:0031099 (regeneration), GO:0030097 (hemopoiesis), GO:0030030 (cell projection organization), GO:0006644 (phospholipid metabolic process), GO:0001944 (vasculature development), GO:0007423 (sensory organ development), GO:1901342 (regulation of vasculature development), GO:0031102 (neuron projection regeneration), GO:0006796 (phosphate-containing compound metabolic process), GO:0030099 (myeloid cell differentiation), GO:0048666 (neuron development), GO:0048678 (response to axon injury), GO:0022008 (neurogenesis), GO:0046486 (glycerolipid metabolic process), GO:0007399 (nervous system development), GO:0072359 (circulatory system development), GO:0031214 (biomineral tissue development), GO:0030258 (lipid modification), GO:0045765 (regulation of angiogenesis), GO:0002275 (myeloid cell activation involved in immune response), GO:0030182 (neuron differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:2000181 (negative regulation of blood vessel morphogenesis), GO:0016525 (negative regulation of angiogenesis), GO:0061515 (myeloid cell development), GO:0016311 (dephosphorylation), GO:0043583 (ear development), GO:0120036 (plasma membrane bounded cell projection organization), GO:0006650 (glycerophospholipid metabolic process), GO:0031103 (axon regeneration), GO:0051896 (regulation of protein kinase B signaling), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0046839 (phospholipid dephosphorylation), GO:0046856 (phosphatidylinositol dephosphorylation), GO:0061564 (axon development), GO:0046488 (phosphatidylinositol metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)