Protein: Tight junction protein ZO-1 isoform X9 (A0A8M3BB27)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein; Cytoplasmic side
InterPro domains:
- IPR001452: SH3 domain (domain) [605-673]
- IPR035597: ZO-1, SH3 domain (domain) [606-670]
- IPR008145: Guanylate kinase/L-type calcium channel beta subunit (domain) [695-892]
- IPR005417: Tight junction protein ZO (family) [334-979]
- IPR008144: Guanylate kinase-like domain (domain) [788-889]
- IPR000906: ZU5 domain (domain) [1527-1663]
- IPR036034: PDZ superfamily (homologous_superfamily) [78-607]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [608-683]
- IPR001478: PDZ domain (domain) [98-593]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [717-901]
Sequence:
MKYQKYITVMQMAMGVTASNKDNCIPPKRQLWVPPASDAPAASAAATSPAAAATASQGKPSLRRIKGRIHRSKSLDSMDLLDCNSTTMEETVIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGLLQENDRVVMVNGVSMDNVEHAYAVQQLRKSGKNAKITIRRKRKVQIPVSRGGERETMSEREEEDDTEEDDYEGPAARAGGASGGTARRNEHSGSTGRRDHSNSRERSVSPRSDRRSVASNNPQRPSKVTLVKSRKNEEYGLRLASHIFVKDISPESLAARDGNIQEGDVVLKINGTVTENLSLIDAKKLIERSKGKLKMVVQRDERATLLNIPDMDDSIPSANSDRDDISEIHSLASDHSHERTRRSRSRSPDKRSEPSDISGHSPQQMSNGRLTGSFPTRKLPLHRSRDEERISKPAALSTPVKMAEDALLAPPSEQPGDKQIPPLPEPKPVYAQPGQPDVDLPVSPSDAPVPSVTHDDSILRRPSMKLVKFKKGESVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFANIIREEAVLFLLDLPRGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHQEVERGIIPNKNRAEQLSSVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPIVIFGPIADVARDKLAREVPDLFELAKTQLPDGREKSEPRDAGTDQRSSGIIRLHTIKQIIDRDKHAVLDITPNAVDRLNYAQWYPIVVFLNPDSKQGVKNMRTRLCSESRKSARKLHERALKLRKNNHHLFTATINMNNMNDGWYGALKDTIQQQQNQLVWVSEGKADGSHDDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGPPSEPAITRSSEPVREDPPVIQEPPGYGGYQPEPINRIDPAGFKAPAPQQMYKKDIYRPNEPVQISQNPMQPNYYQEDKPYRDYDHQPYRYDGGYMEPKARNFDPHFEDSVPPYNDQWGQYDHTSGYEPQTLYEDGLNRLYGHPQSRNDTGYDTGRPRYGKPTSGPIRHDEPPPSRPQYDTQQTSRSPEPPKQQYYDPSQRPSYTQAPQKGYMNSEAPVTPPKPESLSPPLEPALPPPPPPAEAEDDPAMKPQSVLTRVKMFENKRSVSVDRARESADSGIRPVDMVPKPGAASVPKANSLSNLDQEKTFRTPEPQQPQPKVDDIIRSNNNDPDEDEEYYRKQLSYFDRRSFDKPSTQLTPAIKPAQPQTQPAHYPRAESVEKINPAAPSNPAVPPPTLPKPAATPPLDPHGSPKVKPPSHEDTVQSTYLPHKSFPEKSPVNGTGEPPKTNSTATSSYNRFVPKPYTTSARPFERKFDSPKFNHNLLPNDSQNKTDNVKAPITAKPQSSPQPADHDSGLDTFTRTMDHKPKYQQNNINAVPKAIPVSPSALEDDDDDDSHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPDGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKSWQNKSLPGDPNYLVGANCVSVLIDHF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0051051 (negative regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0048523 (negative regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0051049 (regulation of transport), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0044057 (regulation of system process), GO:0043271 (negative regulation of monoatomic ion transport), GO:0016043 (cellular component organization), GO:0034763 (negative regulation of transmembrane transport), GO:0022008 (neurogenesis), GO:0034766 (negative regulation of monoatomic ion transmembrane transport), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0032990 (cell part morphogenesis), GO:0031644 (regulation of nervous system process), GO:0043269 (regulation of monoatomic ion transport), GO:0048858 (cell projection morphogenesis), GO:0034330 (cell junction organization), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0022607 (cellular component assembly), GO:0007416 (synapse assembly), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0050808 (synapse organization), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0010959 (regulation of metal ion transport), GO:0034329 (cell junction assembly), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis), GO:0008045 (motor neuron axon guidance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005911 (cell-cell junction), GO:0043296 (apical junction complex), GO:0070160 (tight junction), GO:0005923 (bicellular tight junction)