Protein: Multidrug resistance protein 1a (A0A9K3Y745)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR003593: AAA+ ATPase domain (domain) [411-1244]
- IPR011527: ABC transporter type 1, transmembrane domain (domain) [50-992]
- IPR039421: Type 1 protein exporter (family) [17-623]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [374-1272]
- IPR017871: ABC transporter-like, conserved site (conserved_site) [523-1182]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [384-1265]
- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [37-1009]
Sequence:
MELEEDLNGRADKNFSKMGKKSKKEKKEKKPAVSVLTMFRYAGWLDRFYMLLGTLAAIIHGIALPLMMLVFGDMTDSFANVGNNRSMSFYNATDIYAKLEDEMTTYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYTIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACESKDGIDNVDMSSKDSGSSLIRRRSTRKSIRGPHDQDGELSTKEALDDDVPPASFWRILKLNSTEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGVFTKNDTPEIQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIRIIEKIPEIDSYSTEGLKPNMLEGNVKFNGVMFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVKAAKEANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMVSVQAGAKRS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0048511 (rhythmic process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0098754 (detoxification), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0007586 (digestion), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:2000241 (regulation of reproductive process), GO:1990961 (xenobiotic detoxification by transmembrane export across the plasma membrane), GO:0051239 (regulation of multicellular organismal process), GO:0048871 (multicellular organismal-level homeostasis), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:2000243 (positive regulation of reproductive process), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0007623 (circadian rhythm), GO:0051234 (establishment of localization), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0006950 (response to stress), GO:0140352 (export from cell), GO:0051094 (positive regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0001101 (response to acid chemical), GO:0001666 (response to hypoxia), GO:0043207 (response to external biotic stimulus), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0009410 (response to xenobiotic stimulus), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0070482 (response to oxygen levels), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0071495 (cellular response to endogenous stimulus), GO:0003013 (circulatory system process), GO:0009725 (response to hormone), GO:0010035 (response to inorganic substance), GO:0050878 (regulation of body fluid levels), GO:0071214 (cellular response to abiotic stimulus), GO:0140115 (export across plasma membrane), GO:0045595 (regulation of cell differentiation), GO:0071496 (cellular response to external stimulus), GO:1902074 (response to salt), GO:0045597 (positive regulation of cell differentiation), GO:0051049 (regulation of transport), GO:0009636 (response to toxic substance), GO:0006970 (response to osmotic stress), GO:1901700 (response to oxygen-containing compound), GO:0010817 (regulation of hormone levels), GO:0010033 (response to organic substance), GO:0071216 (cellular response to biotic stimulus), GO:0060249 (anatomical structure homeostasis), GO:0009991 (response to extracellular stimulus), GO:0104004 (cellular response to environmental stimulus), GO:0022600 (digestive system process), GO:0010941 (regulation of cell death), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:2001023 (regulation of response to drug), GO:0060322 (head development), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0009617 (response to bacterium), GO:0006810 (transport), GO:0046677 (response to antibiotic), GO:0070727 (cellular macromolecule localization), GO:0001894 (tissue homeostasis), GO:0046618 (xenobiotic export from cell), GO:1901652 (response to peptide), GO:0097066 (response to thyroid hormone), GO:0071229 (cellular response to acid chemical), GO:1905395 (response to flavonoid), GO:0071705 (nitrogen compound transport), GO:0071236 (cellular response to antibiotic), GO:1901654 (response to ketone), GO:0032355 (response to estradiol), GO:1902075 (cellular response to salt), GO:0048732 (gland development), GO:0048545 (response to steroid hormone), GO:0050892 (intestinal absorption), GO:0002237 (response to molecule of bacterial origin), GO:0071702 (organic substance transport), GO:0033273 (response to vitamin), GO:0007420 (brain development), GO:0097237 (cellular response to toxic substance), GO:0007399 (nervous system development), GO:0031667 (response to nutrient levels), GO:0036293 (response to decreased oxygen levels), GO:0007417 (central nervous system development), GO:1904478 (regulation of intestinal absorption), GO:1902065 (response to L-glutamate), GO:1901701 (cellular response to oxygen-containing compound), GO:0010038 (response to metal ion), GO:0071417 (cellular response to organonitrogen compound), GO:0003018 (vascular process in circulatory system), GO:0034097 (response to cytokine), GO:0043278 (response to morphine), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:0043200 (response to amino acid), GO:0071310 (cellular response to organic substance), GO:0010232 (vascular transport), GO:0062197 (cellular response to chemical stress), GO:0060284 (regulation of cell development), GO:0071470 (cellular response to osmotic stress), GO:0009914 (hormone transport), GO:0010720 (positive regulation of cell development), GO:1901699 (cellular response to nitrogen compound), GO:0046903 (secretion), GO:0009651 (response to salt stress), GO:0042908 (xenobiotic transport), GO:0001890 (placenta development), GO:0033280 (response to vitamin D), GO:0006972 (hyperosmotic response), GO:0043434 (response to peptide hormone), GO:0032870 (cellular response to hormone stimulus), GO:0010243 (response to organonitrogen compound), GO:0007589 (body fluid secretion), GO:0033993 (response to lipid), GO:0044058 (regulation of digestive system process), GO:0035633 (maintenance of blood-brain barrier), GO:0060856 (establishment of blood-brain barrier), GO:0014070 (response to organic cyclic compound), GO:0008104 (protein localization), GO:0030879 (mammary gland development), GO:0033762 (response to glucagon), GO:0071222 (cellular response to lipopolysaccharide), GO:0071548 (response to dexamethasone), GO:0150104 (transport across blood-brain barrier), GO:1902414 (protein localization to cell junction), GO:0031960 (response to corticosteroid), GO:0033189 (response to vitamin A), GO:0071345 (cellular response to cytokine stimulus), GO:0071474 (cellular hyperosmotic response), GO:0007595 (lactation), GO:0046686 (response to cadmium ion), GO:0015695 (organic cation transport), GO:1901655 (cellular response to ketone), GO:0043279 (response to alkaloid), GO:0014072 (response to isoquinoline alkaloid), GO:1901264 (carbohydrate derivative transport), GO:0071392 (cellular response to estradiol stimulus), GO:0042538 (hyperosmotic salinity response), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0071312 (cellular response to alkaloid), GO:0071383 (cellular response to steroid hormone stimulus), GO:0034612 (response to tumor necrosis factor), GO:0071472 (cellular response to salt stress), GO:0071230 (cellular response to amino acid stimulus), GO:0150105 (protein localization to cell-cell junction), GO:0051384 (response to glucocorticoid), GO:0071549 (cellular response to dexamethasone stimulus), GO:0071475 (cellular hyperosmotic salinity response), GO:0071384 (cellular response to corticosteroid stimulus), GO:1901656 (glycoside transport), GO:0071356 (cellular response to tumor necrosis factor), GO:0071385 (cellular response to glucocorticoid stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045177 (apical part of cell), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098862 (cluster of actin-based cell projections), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0005903 (brush border), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0031526 (brush border membrane), GO:0031253 (cell projection membrane)