Protein: NF-kappa-B essential modulator (A0A8I5KQX5)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR034735: NEMO, Zinc finger (domain) [338-368]
- IPR032419: NF-kappa-B essential modulator NEMO, CC2-LZ domain (domain) [206-293]
- IPR051301: Optineurin/NF-kappa-B Essential Modulator (family) [170-368]
- IPR021063: NF-kappa-B essential modulator NEMO, N-terminal (domain) [44-111]
Sequence:
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0032182 (ubiquitin-like protein binding), GO:0140030 (modification-dependent protein binding), GO:0005102 (signaling receptor binding), GO:0046983 (protein dimerization activity), GO:0042802 (identical protein binding), GO:0019904 (protein domain specific binding), GO:0019899 (enzyme binding), GO:0031593 (polyubiquitin modification-dependent protein binding), GO:0044389 (ubiquitin-like protein ligase binding), GO:0042803 (protein homodimerization activity), GO:0046982 (protein heterodimerization activity), GO:0043130 (ubiquitin binding), GO:0031625 (ubiquitin protein ligase binding), GO:0070530 (K63-linked polyubiquitin modification-dependent protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0006955 (immune response), GO:0002684 (positive regulation of immune system process), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0009607 (response to biotic stimulus), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0051640 (organelle localization), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0044093 (positive regulation of molecular function), GO:0012501 (programmed cell death), GO:0044085 (cellular component biogenesis), GO:0043207 (response to external biotic stimulus), GO:0060548 (negative regulation of cell death), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009966 (regulation of signal transduction), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:0051648 (vesicle localization), GO:0045087 (innate immune response), GO:0009891 (positive regulation of biosynthetic process), GO:0098542 (defense response to other organism), GO:0050776 (regulation of immune response), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0051656 (establishment of organelle localization), GO:0031325 (positive regulation of cellular metabolic process), GO:0033554 (cellular response to stress), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0016043 (cellular component organization), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009615 (response to virus), GO:1901215 (negative regulation of neuron death), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0006974 (cellular response to DNA damage stimulus), GO:1901214 (regulation of neuron death), GO:0051650 (establishment of vesicle localization), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0006954 (inflammatory response), GO:0050854 (regulation of antigen receptor-mediated signaling pathway), GO:0050857 (positive regulation of antigen receptor-mediated signaling pathway), GO:0006915 (apoptotic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0007249 (I-kappaB kinase/NF-kappaB signaling), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:1902533 (positive regulation of intracellular signal transduction), GO:0043933 (protein-containing complex organization), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0065003 (protein-containing complex assembly), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0051092 (positive regulation of NF-kappaB transcription factor activity), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling), GO:0050856 (regulation of T cell receptor signaling pathway), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)