Protein: Neurotrophic receptor tyrosine kinase 2 (A0A8I5KR47)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR000372: Leucine-rich repeat N-terminal domain (domain) [31-65]
- IPR013098: Immunoglobulin I-set (domain) [204-361]
- IPR020777: Growth factor receptor NTRK (family) [86-348]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [193-372]
- IPR003598: Immunoglobulin subtype 2 (domain) [209-273]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [32-185]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [203-370]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [148-195]
- IPR031635: Growth factor receptor NTRK, leucine rich repeat C-terminal (domain) [151-195]
- IPR007110: Immunoglobulin-like domain (domain) [197-282]
- IPR001611: Leucine-rich repeat (repeat) [92-149]
- IPR020455: BDNF/NT-3 growth factors receptor NTRK2 (family) [16-330]
- IPR003599: Immunoglobulin domain subtype (domain) [203-284]
Sequence:
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHYHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGFVLFHKIPLDG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019838 (growth factor binding), GO:0019955 (cytokine binding), GO:0050431 (transforming growth factor beta binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007155 (cell adhesion), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:1904018 (positive regulation of vasculature development), GO:2000026 (regulation of multicellular organismal development), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0007166 (cell surface receptor signaling pathway), GO:0008284 (positive regulation of cell population proliferation), GO:0035239 (tube morphogenesis), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0048514 (blood vessel morphogenesis), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:1901342 (regulation of vasculature development), GO:0001570 (vasculogenesis), GO:0045766 (positive regulation of angiogenesis), GO:0045765 (regulation of angiogenesis), GO:0042981 (regulation of apoptotic process), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0043066 (negative regulation of apoptotic process), GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)