lokahq/bioreason-rl huggingface dataset:
Protein: PNKD metallo-beta-lactamase domain containing (A0A8J8ZTU4)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR017782: Hydroxyacylglutathione hydrolase (family) [119-379]
- IPR032282: Hydroxyacylglutathione hydrolase, C-terminal domain (domain) [289-377]
- IPR035680: Hydroxyacylglutathione hydrolase, MBL domain (domain) [123-288]
- IPR001279: Metallo-beta-lactamase (domain) [129-288]
- IPR036866: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like (homologous_superfamily) [119-382]
Sequence:
MAAVVAATALKGRGARNARVLRGILAGATANKASHNRTRALQSHSSPEGKEEPEPLSPELEYIPRKRGKNPMKAVGLAWYSLYTRTWLGYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDPSDPRAVQASIEKEGVTLVAILCTHKHCGGNRDLSRRHRDCRVYGSPQDGIPYLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCGRTFEGNAETMLSSLDTVLGLGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKGTCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065008 (regulation of biological quality), GO:0023051 (regulation of signaling), GO:0051051 (negative regulation of transport), GO:0048523 (negative regulation of cellular process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051589 (negative regulation of neurotransmitter transport), GO:0001505 (regulation of neurotransmitter levels), GO:1903530 (regulation of secretion by cell), GO:0099177 (regulation of trans-synaptic signaling), GO:0051049 (regulation of transport), GO:0010646 (regulation of cell communication), GO:0051048 (negative regulation of secretion), GO:1903531 (negative regulation of secretion by cell), GO:0051588 (regulation of neurotransmitter transport), GO:0051046 (regulation of secretion), GO:0046928 (regulation of neurotransmitter secretion), GO:0050804 (modulation of chemical synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Chloride channel CLIC-like protein 1 (A0A6Q8PEZ7)
Organism: Homo sapiens (Human)
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR009231: Chloride channel CLIC-like (family) [1-568]
Sequence:
MLCSLLLCECLLLVAGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGISGEKDVSPDLSCADEISECYHKLDSLTYKIDECEKKKREDYESQSNPVFRRYLNKILIEAGKLGLPDENKGDMHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILINFKFHDFETWKWRFEDSFGVDPYNVLMVLLCLLCIVVLVATELWTYVRWYTQLRRVLIISFLFSLGWNWMYLYKLAFAQHQAEVAKMEPLNNVCAKKMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTTFVTEPLKHIGKGTGEFIKALMKEIPALLHLPVLIIMALAILDLFAVLKIEAHKQLLLKSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSQSAKPVSGQDTSGNTEGSPAAEKAQLKSEAAGSPDQGSTYSPARGVAGPRGQDPVSSPCG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0006812 (monoatomic cation transport), GO:0015886 (heme transport), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006826 (iron ion transport), GO:1901678 (iron coordination entity transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0012505 (endomembrane system), GO:0044232 (organelle membrane contact site), GO:0043229 (intracellular organelle), GO:0044233 (mitochondria-associated endoplasmic reticulum membrane), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: NACHT, LRR and PYD domains-containing protein 1 (I3L0S2)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR011029: Death-like domain superfamily (homologous_superfamily) [1-35]
- IPR004020: DAPIN domain (domain) [1-35]
Sequence:
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Acyl-CoA-binding domain-containing protein 5 (A0A7I2YQJ9)
Organism: Homo sapiens (Human)
Function: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters
Subcellular location: Membrane; Single- pass membrane protein. Peroxisome membrane; Single-pass membrane protein
InterPro domains:
- IPR022408: Acyl-CoA-binding protein, ACBP, conserved site (conserved_site) [30-48]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [6-103]
- IPR035984: Acyl-CoA binding protein superfamily (homologous_superfamily) [9-94]
- IPR000582: Acyl-CoA-binding protein, ACBP (domain) [8-97]
- IPR016347: Acyl-CoA-binding domain-containing protein 5 (family) [1-518]
Sequence:
MADTRSVHETRFEAAVKVIQSLPKNGSFQPTNEMMLKFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKIIETMPMTEKVEELLRVIGPFYEIVEDKKSGRSSDITSVRLEKISKCLEEPGFCHVGQADLELLTSDLGNVLTSTPNAKTVNGKAESSDSGAESEEEEAQEEVKGAEQSDNDKKMMKKSADHKNLEVIVTNGYDKDGFVQDIQNDIHASSSLNGRSTEEVKPIDENLGQTGKSAVCIHQDINDDHVEDVTGIQHLTSDSDSEVYCDSMEQFGQEESLDSFTSNNGPFQYYLGGHSSQPMENSGFREDIQVPPGNGNIGNMQVVAVEGKGEVKHGGEDGRNNSGAPHREKRGGETDEFSNVRRGRGHRMQHLSEGTKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLMRLQEDMQNVLQRLQKLETLTALQAKSSTSTLQTAPQPTSQRPSWWPFEMSPGVLTFAIIWPFIAQWLVYLYYQRRRRKLN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0044248 (cellular catabolic process), GO:0006914 (autophagy), GO:0030242 (autophagy of peroxisome)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0042579 (microbody), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: G protein signaling modulator 2 (A0A6Q8PFD2)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR003109: GoLoco motif (conserved_site) [470-492]
- IPR019734: Tetratricopeptide repeat (repeat) [43-336]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [1-514]
- IPR052386: G-protein-signaling modulator (family) [1-514]
Sequence:
MEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYSTNNSIMSENTEIDSSLNGVRPKLGRRHSMENMELMKLTPEKVQNWNSEILAKQKPLIAKPSAKLLFVNRLKGKKYKTNSSTKVLQDASNSIDHRIPNSQRKISADTIGDEGFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSSTPPKMMLKRIQIR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007017 (microtubule-based process), GO:0071840 (cellular component organization or biogenesis), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0031023 (microtubule organizing center organization), GO:0007098 (centrosome cycle), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Required for meiotic nuclear division 1 homolog (A0A804HHW6)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR051624: RMD1/Sad1-interacting (family) [37-439]
- IPR003734: Domain of unknown function DUF155 (domain) [226-403]
Sequence:
MPATLLRAVARSHHILSKAHQCRRIGHLMLKPLKEFENTTCSTLTIRQSLDLFLPDKTASGLNKSQILEMNQKKSDTSMLSPLNAARCQDEKAHLPTMKSFGTHRRVTHKPNLLGSKWFIKILKRHFSSVSTETFVPKQDFPQVKRPLKASRTRQPSRTNLPVLSVNEDLMHCTAFATADEYHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVKDKTMKHVMKVLEKHEIQPYEIALVHWENEELNYIKIEGQSKLHRGEIKLNSELDLDDAILEKFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKVKLSHEEVMQKIGELFALRHRINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMELTDLMRNHLNEKRALRLEWMIVILITIETQSQSVTQAAVHWHNLGSLQALPPGFKRFSCLSLPSSWDYRRASPCQAIIRDGVSPFWPGCSQTPDLVICPLQPSKVLGLQE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0034248 (regulation of amide metabolic process), GO:0034250 (positive regulation of amide metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0010628 (positive regulation of gene expression), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0006417 (regulation of translation), GO:0045727 (positive regulation of translation), GO:0062125 (regulation of mitochondrial gene expression), GO:0010608 (post-transcriptional regulation of gene expression), GO:0070131 (positive regulation of mitochondrial translation), GO:0070129 (regulation of mitochondrial translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Acyl-CoA-binding domain-containing protein 5 (A0A7I2YQD7)
Organism: Homo sapiens (Human)
Function: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters
Subcellular location: Membrane; Single- pass membrane protein. Peroxisome membrane; Single-pass membrane protein
InterPro domains:
- IPR022408: Acyl-CoA-binding protein, ACBP, conserved site (conserved_site) [30-48]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [6-103]
- IPR035984: Acyl-CoA binding protein superfamily (homologous_superfamily) [9-94]
- IPR000582: Acyl-CoA-binding protein, ACBP (domain) [8-97]
- IPR016347: Acyl-CoA-binding domain-containing protein 5 (family) [1-488]
Sequence:
MADTRSVHETRFEAAVKVIQSLPKNGSFQPTNEMMLKFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKIIETMPMTEKVEELLRVIGPFYEIVEDKKSGRSSDITSDLGNVLTSTPNAKTVNGKAESSDSGAESEEEEAQEEVKGAEQSDNDKKMMKKSADHKNLEVIVTNGYDKDGFVQDIQNDIHASSSLNGRSTEEVKPIDENLGQTGKSAVCIHQDINDDHVEDVTGIQHLTSDSDSEVYCDSMEQFGQEESLDSFTSNNGPFQYYLGGHSSQPMENSGFREDIQVPPGNGNIGNMQVVAVEGKGEVKHGGEDGRNNSGAPHREKRGGETDEFSNVRRGRGHRMQHLSEGTKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLMRLQEDMQNVLQRLQKLETLTALQAKSSTSTLQTAPQPTSQRPSWWPFEMSPGVLTFAIIWPFIAQWLVYLYYQRRRRVLLCHLGWSAVARSQLTATSASQVQAILLPQPPK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0044248 (cellular catabolic process), GO:0006914 (autophagy), GO:0030242 (autophagy of peroxisome)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0042579 (microbody), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: NADH:ubiquinone oxidoreductase complex assembly factor 2 (A0A7I2YQX2)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR052618: Complex I NDUFA12 subunit (family) [1-86]
- IPR007763: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (family) [22-89]
Sequence:
MGWSQDLFRALWRSLSREVKEHVGTDQFGNKYYYIPQYKNWRGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMESCSVTKAGIQWHDLSSLQPLPPRFKQFPCLSLPKSWDYRHVPPHPANFCILVEMRFYHIGQAGLKLLASSNLPTLASPKCWDYRHEPLRPA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0010257 (NADH dehydrogenase complex assembly), GO:0032981 (mitochondrial respiratory chain complex I assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Ankyrin 2 (H0Y933)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton. Membrane
InterPro domains:
- IPR011029: Death-like domain superfamily (homologous_superfamily) [3602-3721]
- IPR051165: Multifunctional Ankyrin Repeat Domain-Containing Protein (family) [606-1516]
- IPR000906: ZU5 domain (domain) [1013-1351]
- IPR040745: Ankyrin, UPA domain (domain) [1371-1500]
- IPR002110: Ankyrin repeat (repeat) [47-830]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [34-862]
- IPR000488: Death domain (domain) [3606-3700]
Sequence:
XSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEVTLCEPSILSSTSQFQAEPVEGRRVSKVVKTTVVLGERMEKHLGDSSLATDLPSAKDDFEEALSYTGSHMKVHLPSLVENEILKEDGSIIKRTTMSKAITQKRAVVKDQHGKRIDLEHLEDVPEALDQDDLQRDLQQLLRHFCKEDLKQEAK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0051239 (regulation of multicellular organismal process), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0001817 (regulation of cytokine production), GO:1903555 (regulation of tumor necrosis factor superfamily cytokine production), GO:0032675 (regulation of interleukin-6 production), GO:0010468 (regulation of gene expression), GO:0032680 (regulation of tumor necrosis factor production)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Protein disulfide-isomerase (A0A7P0T9D6)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane; Peripheral membrane protein. Endoplasmic reticulum lumen. Melanosome. Membrane; Peripheral membrane protein
InterPro domains:
- IPR005792: Protein disulphide isomerase (family) [25-392]
- IPR017937: Thioredoxin, conserved site (conserved_site) [45-63]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [24-365]
- IPR005788: Protein disulfide-isomerase, thioredoxin-like domain (domain) [30-132]
- IPR013766: Thioredoxin domain (domain) [8-134]
Sequence:
MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFCKCCPFSSPGPCHQGTRKMPHGVVTANSWLPFGINWERRTRTMRTSSSPRWTRLPTRWRPSKCTASPHSSSFLPVPTGRSLITTGNARWMVLRNSWRAVARMGQGMMTISRTWKKQRSQTWRKTMIRKL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0003756 (protein disulfide isomerase activity), GO:0016860 (intramolecular oxidoreductase activity), GO:0015035 (protein-disulfide reductase activity), GO:0015036 (disulfide oxidoreductase activity), GO:0016864 (intramolecular oxidoreductase activity, transposing S-S bonds)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006457 (protein folding), GO:0006091 (generation of precursor metabolites and energy), GO:0022900 (electron transport chain)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)