Protein: Unconventional myosin-VI (A0A8M9P8V8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, filopodium. Cell projection, microvillus. Cell projection, ruffle membrane. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Membrane, clathrin-coated pit
InterPro domains:
- IPR049016: Myosin VI, lever arm (domain) [769-916]
- IPR004009: Myosin, SH3 domain (domain) [2-53]
- IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [51-703]
- IPR032412: Myosin VI, cargo binding domain (domain) [1147-1237]
- IPR036114: Class VI myosin, motor domain (domain) [71-758]
- IPR008989: Myosin S1 fragment, N-terminal (homologous_superfamily) [1-50]
- IPR001609: Myosin head, motor domain-like (domain) [51-771]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [33-833]
Sequence:
MDDGKPVWAPHPTDGFQLGMIVDIGADALTIEPLHQRGKTFLAPISQVFPAEDDVNKHVEDNCSLMYLNEATLLNNIRIRYSKDMIYTFVANILIAVNPYFDIPKLYSPESIKSYQGRSLGTLPPHVYAIADKAYRDMRVLKMSQSIIVSGESGAGKTENTKFVLRYLTTSYGTGQDIDERIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKNAVVGGFVSHYLLEKSRICMQSQEERNYHIFYRLCAGASEDIRNMLHLNSPDSFRYLNRGCTRYFANKDSDKQIMQNRKSPEHGKVGALKDPLLDDLGDFNRMVVAMKKIGLDDTEKLNLFRVVAGVLHLGNIDFEETGSTSGGCILKNQSSQTLEYCADLLGLDQDDLRVSLTTRVMLTTAGGAKGTVIKVPLKVEQANNARDALAKAVYSRLFDHVVKRVNQCFPFDTSSNFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQREGLGVNEVHYVDNQDCIDLVEAKLVGVLDILDEENRLPQPSDQHFAEAVHSKHKDHFRLTVPRKSKLTIHRNLRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLVCESKDKFVRDLFENNSNSKDSKQKAGKLSFISVGNKFKTQLNLLLEKLRSTGSSFIRCVKPNLKMVSHQFEGAQILSQLQCSGMVSVLDLMQGGFPSRAPFHELYNMYKQYMPNKLTRLDPRLFCKALFKALGLNENDYKFGLTRVFFRPGKFAEFDQIMKSDPDHLAELVKRVNKWLVCSRWKKVQWCTLSVIKLRNKMSYRASACIRIQKTVRMWLCRRRHKPRVDGLVKVKNLRKRMERFNEAVNGLKEGKAEMSKQIEELAASTDALMAKIKTTVMSRKEIEQEYEGLVKRSEQLLSSMQKKKQEQEETERLKHIQEEMEKERKRHEEEEQLRKQEEEDRRMKSEMEQKRKQEEEERKKREEEERVLQAELEMQLALDREEETQRQTILEQERRDRELAMRIAQNEAELIQDEAQMDPILRRDATTGVWFFTEMGAQVQANKVAAGVKKYDLSKWKYAELRDAINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTDTEMRAPKSVTDYAQQNPAPPVPARQQEIAMNRQQRYFRIPFIRPADQYKDPQNKKKGWWYAHFDGPWIARQMELHPDKQPILLVAGKDDMEMCELSLEETGLTRKRGAEILPRQFEEIWERCGGIQYLKNAIESKQARPTYATAMLQNLLK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051606 (detection of stimulus), GO:0003008 (system process), GO:0009581 (detection of external stimulus), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009582 (detection of abiotic stimulus), GO:0050877 (nervous system process), GO:0009612 (response to mechanical stimulus), GO:0048839 (inner ear development), GO:0050906 (detection of stimulus involved in sensory perception), GO:0050974 (detection of mechanical stimulus involved in sensory perception), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0008544 (epidermis development), GO:0007423 (sensory organ development), GO:0060113 (inner ear receptor cell differentiation), GO:0050982 (detection of mechanical stimulus), GO:0060429 (epithelium development), GO:0030182 (neuron differentiation), GO:0007600 (sensory perception), GO:0030855 (epithelial cell differentiation), GO:0042490 (mechanoreceptor differentiation), GO:0035315 (hair cell differentiation), GO:0048699 (generation of neurons), GO:0009913 (epidermal cell differentiation), GO:0043583 (ear development), GO:0050954 (sensory perception of mechanical stimulus), GO:0042491 (inner ear auditory receptor cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0048471 (perinuclear region of cytoplasm), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0098833 (presynaptic endocytic zone), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0098862 (cluster of actin-based cell projections), GO:0031090 (organelle membrane), GO:0099571 (postsynaptic cytoskeleton), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0005903 (brush border), GO:0045202 (synapse), GO:0043228 (non-membrane-bounded organelle), GO:0043025 (neuronal cell body), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0098871 (postsynaptic actin cytoskeleton), GO:0098685 (Schaffer collateral - CA1 synapse), GO:0097470 (ribbon synapse), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0012506 (vesicle membrane), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0043005 (neuron projection), GO:0098984 (neuron to neuron synapse), GO:0031982 (vesicle), GO:0032279 (asymmetric synapse), GO:0005856 (cytoskeleton), GO:0030424 (axon), GO:0015629 (actin cytoskeleton)