Protein: Sodium/hydrogen exchanger 1 (P23791)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (Probable). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR006153: Cation/H+ exchanger, transmembrane domain (domain) [110-503]
- IPR001970: Sodium/hydrogen exchanger 1-like (family) [14-811]
- IPR004709: Na+/H+ exchanger (family) [95-660]
- IPR032103: Sodium/hydrogen exchanger, regulatory region (domain) [600-685]
- IPR018422: Cation/H+ exchanger, CPA1 family (family) [59-652]
Sequence:
MLLWSAVRGLSPPRIVPSLLVVVALAGLLPGLRSHGLQLSPTDSTTPDSQPSRERSIGDVTTAPPEVTPESRPVNRSVTEHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGEKPPFLQSEVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYDHVGIVDIVLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTAHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKALPAERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPVITIDPASPQSPESVDLVNEELKGKVLGLSREPRVAEEAAEEDEDGGIVMRPKEPSSPGTDDVFSPAPSDSPSSQRMQRCLSDPGPHPEPGEGEPFIPKGQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0015078 (proton transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0140828 (metal cation:monoatomic cation antiporter activity), GO:0015385 (sodium:proton antiporter activity), GO:0051139 (metal cation:proton antiporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0055085 (transmembrane transport), GO:0140352 (export from cell), GO:0140115 (export across plasma membrane), GO:0009268 (response to pH), GO:0104004 (cellular response to environmental stimulus), GO:0034220 (monoatomic ion transmembrane transport), GO:0006810 (transport), GO:0098660 (inorganic ion transmembrane transport), GO:0071214 (cellular response to abiotic stimulus), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0010447 (response to acidic pH), GO:0006811 (monoatomic ion transport), GO:0036376 (sodium ion export across plasma membrane), GO:0071467 (cellular response to pH), GO:0071468 (cellular response to acidic pH), GO:0035725 (sodium ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098862 (cluster of actin-based cell projections), GO:0009986 (cell surface), GO:0005903 (brush border)