Protein: ATPase copper transporting alpha (A0A8I5KPN6)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR017969: Heavy-metal-associated, conserved site (conserved_site) [14-571]
- IPR036163: Heavy metal-associated domain superfamily (homologous_superfamily) [8-606]
- IPR006121: Heavy metal-associated domain, HMA (domain) [8-602]
- IPR006122: Heavy metal-associated domain, copper ion-binding (domain) [10-601]
Sequence:
MDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIYPQKRTVAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0036094 (small molecule binding), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0022857 (transmembrane transporter activity), GO:0043167 (ion binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0140358 (P-type transmembrane transporter activity), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0043169 (cation binding), GO:0022804 (active transmembrane transporter activity), GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity), GO:0000166 (nucleotide binding), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0032553 (ribonucleotide binding), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0017076 (purine nucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0015399 (primary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015662 (P-type ion transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0032555 (purine ribonucleotide binding), GO:0046872 (metal ion binding), GO:0005524 (ATP binding), GO:0046914 (transition metal ion binding), GO:0032559 (adenyl ribonucleotide binding), GO:0046873 (metal ion transmembrane transporter activity), GO:0030554 (adenyl nucleotide binding), GO:0005507 (copper ion binding), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0005375 (copper ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0098754 (detoxification), GO:0042592 (homeostatic process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0042221 (response to chemical), GO:0055085 (transmembrane transport), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051050 (positive regulation of transport), GO:0019725 (cellular homeostasis), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0051651 (maintenance of location in cell), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:1990748 (cellular detoxification), GO:0048878 (chemical homeostasis), GO:0044237 (cellular metabolic process), GO:0051235 (maintenance of location), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0010942 (positive regulation of cell death), GO:2000145 (regulation of cell motility), GO:0044085 (cellular component biogenesis), GO:0098660 (inorganic ion transmembrane transport), GO:0044248 (cellular catabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0034220 (monoatomic ion transmembrane transport), GO:0010035 (response to inorganic substance), GO:0046907 (intracellular transport), GO:0071806 (protein transmembrane transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0050801 (monoatomic ion homeostasis), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0006979 (response to oxidative stress), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0009636 (response to toxic substance), GO:0034762 (regulation of transmembrane transport), GO:0051649 (establishment of localization in cell), GO:0098771 (inorganic ion homeostasis), GO:0043170 (macromolecule metabolic process), GO:2000147 (positive regulation of cell motility), GO:0009891 (positive regulation of biosynthetic process), GO:0097501 (stress response to metal ion), GO:0010941 (regulation of cell death), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0034599 (cellular response to oxidative stress), GO:0098655 (monoatomic cation transmembrane transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043067 (regulation of programmed cell death), GO:0045182 (translation regulator activity), GO:0030334 (regulation of cell migration), GO:0044743 (protein transmembrane import into intracellular organelle), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0043412 (macromolecule modification), GO:0097237 (cellular response to toxic substance), GO:0010594 (regulation of endothelial cell migration), GO:0030335 (positive regulation of cell migration), GO:0043933 (protein-containing complex organization), GO:0051252 (regulation of RNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:1901701 (cellular response to oxygen-containing compound), GO:0010038 (response to metal ion), GO:0098655 (monoatomic cation transmembrane transport), GO:0010038 (response to metal ion), GO:0051336 (regulation of hydrolase activity), GO:0062197 (cellular response to chemical stress), GO:0043068 (positive regulation of programmed cell death), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0000305 (response to oxygen radical), GO:0036211 (protein modification process), GO:0098662 (inorganic cation transmembrane transport), GO:0055080 (monoatomic cation homeostasis), GO:0071241 (cellular response to inorganic substance), GO:0031326 (regulation of cellular biosynthetic process), GO:0010634 (positive regulation of epithelial cell migration), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0022898 (regulation of transmembrane transporter activity), GO:0043269 (regulation of monoatomic ion transport), GO:0000302 (response to reactive oxygen species), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0006878 (intracellular copper ion homeostasis), GO:0042981 (regulation of apoptotic process), GO:0006812 (monoatomic cation transport), GO:0065003 (protein-containing complex assembly), GO:2001141 (regulation of RNA biosynthetic process), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:0010959 (regulation of metal ion transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0010039 (response to iron ion), GO:1902680 (positive regulation of RNA biosynthetic process), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0034614 (cellular response to reactive oxygen species), GO:2001242 (regulation of intrinsic apoptotic signaling pathway), GO:0043065 (positive regulation of apoptotic process), GO:0043066 (negative regulation of apoptotic process), GO:0006355 (regulation of DNA-templated transcription), GO:0071248 (cellular response to metal ion), GO:0045862 (positive regulation of proteolysis), GO:0046688 (response to copper ion), GO:0006816 (calcium ion transport), GO:0014074 (response to purine-containing compound), GO:0070301 (cellular response to hydrogen peroxide), GO:0071280 (cellular response to copper ion), GO:0030001 (metal ion transport), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0010155 (regulation of proton transport), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0071276 (cellular response to cadmium ion), GO:2000142 (regulation of DNA-templated transcription initiation), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000041 (transition metal ion transport), GO:0006825 (copper ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)