Protein: Adenylosuccinate synthetase isozyme 2 (A6JGD7)
Organism: Rattus norvegicus (Rat)
Function: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP
Subcellular location: Cytoplasm. Mitochondrion
InterPro domains:
- IPR033128: Adenylosuccinate synthase, active site (active_site) [165-176]
- IPR042109: Adenylosuccinate synthetase, domain 1 (homologous_superfamily) [32-296]
- IPR027529: Adenylosuccinate synthetase isozyme 2, chordates (family) [3-456]
- IPR042111: Adenylosuccinate synthetase, domain 3 (homologous_superfamily) [297-456]
- IPR042110: Adenylosuccinate synthetase, domain 2 (homologous_superfamily) [131-230]
- IPR001114: Adenylosuccinate synthetase (family) [1-456]
- IPR018220: Adenylosuccinate synthase, GTP-binding site (binding_site) [37-44]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [29-454]
Sequence:
MSISESSPAATSLPNGDCGRPRARPGGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLDGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQQLKGYMERIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGETIPHFPANQEVLNKVEVQYKTLPGWNTDISNARTFKELPVNAQNYVRFIEDELQIPVKWIGVGKSRESMIQLF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0016879 (ligase activity, forming carbon-nitrogen bonds)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051716 (cellular response to stimulus), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0051602 (response to electrical stimulus), GO:0010035 (response to inorganic substance), GO:1901360 (organic cyclic compound metabolic process), GO:0104004 (cellular response to environmental stimulus), GO:1901564 (organonitrogen compound metabolic process), GO:1901698 (response to nitrogen compound), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0071214 (cellular response to abiotic stimulus), GO:0019637 (organophosphate metabolic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0010033 (response to organic substance), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0010243 (response to organonitrogen compound), GO:0043436 (oxoacid metabolic process), GO:0019693 (ribose phosphate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0060359 (response to ammonium ion), GO:0014070 (response to organic cyclic compound), GO:0071257 (cellular response to electrical stimulus), GO:0072521 (purine-containing compound metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009123 (nucleoside monophosphate metabolic process), GO:0009117 (nucleotide metabolic process), GO:0009066 (aspartate family amino acid metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0014074 (response to purine-containing compound), GO:0009150 (purine ribonucleotide metabolic process), GO:0009161 (ribonucleoside monophosphate metabolic process), GO:0006531 (aspartate metabolic process), GO:0009126 (purine nucleoside monophosphate metabolic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0009167 (purine ribonucleoside monophosphate metabolic process), GO:0046040 (IMP metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)