Protein: Acetylcholine receptor subunit delta (P04759)
Organism: Bos taurus (Bovine)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane
Subcellular location: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR006201: Neurotransmitter-gated ion-channel (family) [22-484]
- IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [25-245]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [21-249]
- IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [250-499]
- IPR002394: Nicotinic acetylcholine receptor (family) [60-148]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [252-488]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [245-496]
- IPR018000: Neurotransmitter-gated ion-channel, conserved site (conserved_site) [150-164]
Sequence:
MEGSVLTLVLLAALVVCGSWGLNEEERLIRHLFEEKAYNKELRPAAHKESVEISLALTLSNLISLKEVEETLTTNVWIEQGWTDSRLQWDAEDFGNISVLRLPADMVWLPEIVLENNNDGSFQISYSCNVLIYPSGSVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTTKEITLSLKQAEEDGRSYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPSVPLDSPNRQDVTFYLIIRRKPLFYVINILVPCVLISFMINLVFYLPADCGEKTSMAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEPVKKLFLETLPEILHMSRPAEDGPSPGTLIRRSSSLGYISKAEEYFSLKSRSDLMFEKQSERHGLARRLTTARRPPAGSEQAQQELFSELKPAVDGANFIVNHMKDQNNYNEEKDCWNRVARTVDRLCLFVVTPIMVVGTAWIFLQGAYNQPPPQPFPGDPFSYLEKDKRFI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0060089 (molecular transducer activity), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0030594 (neurotransmitter receptor activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0098960 (postsynaptic neurotransmitter receptor activity), GO:0022835 (transmitter-gated channel activity), GO:0015267 (channel activity), GO:0022824 (transmitter-gated monoatomic ion channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099529 (neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential), GO:1904315 (transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0005215 (transporter activity), GO:0060089 (molecular transducer activity), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0030594 (neurotransmitter receptor activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0098960 (postsynaptic neurotransmitter receptor activity), GO:0022835 (transmitter-gated channel activity), GO:0015267 (channel activity), GO:0022824 (transmitter-gated monoatomic ion channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099529 (neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential), GO:1904315 (transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0045202 (synapse), GO:0031594 (neuromuscular junction)