Protein: Synembryn (A0A8M3AQQ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP
Subcellular location: Cytoplasm
InterPro domains:
- IPR019318: Guanine nucleotide exchange factor, Ric8 (family) [5-677]
- IPR008376: Chaperone Ric-8 A/B (domain) [475-633]
- IPR016024: Armadillo-type fold (homologous_superfamily) [249-550]
Sequence:
MTVDVEKIIQFIKQGDQDNVQSHLDDYNTENSQCFFFDVEERERKKFRRNKVREYVPDSDSDCDSDNSEDPDLVLRRRLAAALIWFIRMRLQPGVLRVCLRTLRIISRDRKALAPLITDYAIITLARLGGISALPTWPEEEDDQWGSSHNDVAPENETDTLPDNDTNTQCPACCSETDDSCCGSTVCAASSVREGGLHFSPMNNTSNPRETQNDHCEESVRKDGVCGLLTRGKRETRGERDEEGEEGHDDGEIWRKEAMKTLCNVIYNSPKAQERASTLRLLHGLSVRIKDGIHSSSPPSGQFYELRLLFLLTALRPELRIELCQERGVSMLTAALEQCLDVIWGETHEVLTDLTAPPLCKELSQRALEILKTLFNITYSVHRQDLDEEAAALYRRLAAVLRHCLLVPCEGEDRKEELQGHTVNVLSALPLQCLDVLLSVRLSEGSEESGGVNMDCVHTLLLFMEKRLDRGHKLKEKLTPVLNLLTESSKAHRETRHYLRQQILPPLRDVELRPEQGNTLRSRLVRLMTHVDTDIKHCAAELLFVLCKENVSRFVKYTGYGNAAGLLAARGLLNGRGSSPQPQYSSDSDSDTEEYRQARDRINPVTGRVEEEQPDPMEGMTEEEKEAEALRLINMFNRLSRGKIIQPMGVTTDGKLAPLCGQTRHSAVQEEEEEDEEDDDCSETEQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0007155 (cell adhesion), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0003008 (system process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007610 (behavior), GO:0048598 (embryonic morphogenesis), GO:0098609 (cell-cell adhesion), GO:0007611 (learning or memory), GO:0009314 (response to radiation), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0048731 (system development), GO:0007632 (visual behavior), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0050877 (nervous system process), GO:0016477 (cell migration), GO:0008542 (visual learning), GO:0050890 (cognition), GO:0009416 (response to light stimulus), GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules), GO:0043062 (extracellular structure organization), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0007369 (gastrulation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0007612 (learning), GO:0045229 (external encapsulating structure organization), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0001667 (ameboidal-type cell migration), GO:0043009 (chordate embryonic development), GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway), GO:0042074 (cell migration involved in gastrulation), GO:0030198 (extracellular matrix organization), GO:0001702 (gastrulation with mouth forming second), GO:0008306 (associative learning), GO:0071711 (basement membrane organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)