Protein: Nucleophosmin (A0A7I2V5S2)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus, nucleolus. Nucleus, nucleoplasm
InterPro domains:
- IPR004301: Nucleoplasmin family (family) [5-302]
- IPR036824: Nucleoplasmin core domain superfamily (homologous_superfamily) [12-117]
- IPR032569: Nucleophosmin, C-terminal (domain) [245-304]
- IPR024057: Nucleoplasmin core domain (domain) [18-117]
Sequence:
MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKFLACIHNLKEMGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0060090 (molecular adaptor activity), GO:0030234 (enzyme regulator activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0097159 (organic cyclic compound binding), GO:0003712 (transcription coregulator activity), GO:0140678 (molecular function inhibitor activity), GO:1901363 (heterocyclic compound binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0042393 (histone binding), GO:0140693 (molecular condensate scaffold activity), GO:0042802 (identical protein binding), GO:0004857 (enzyme inhibitor activity), GO:0003713 (transcription coactivator activity), GO:0043021 (ribonucleoprotein complex binding), GO:0003676 (nucleic acid binding), GO:0051082 (unfolded protein binding), GO:0046983 (protein dimerization activity), GO:0019899 (enzyme binding), GO:0019207 (kinase regulator activity), GO:0043023 (ribosomal large subunit binding), GO:0043024 (ribosomal small subunit binding), GO:0019210 (kinase inhibitor activity), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0019900 (kinase binding), GO:0019887 (protein kinase regulator activity), GO:0140297 (DNA-binding transcription factor binding), GO:0042803 (protein homodimerization activity), GO:0003677 (DNA binding), GO:0003723 (RNA binding), GO:0043565 (sequence-specific DNA binding), GO:0019843 (rRNA binding), GO:0004860 (protein kinase inhibitor activity), GO:0000976 (transcription cis-regulatory region binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0003690 (double-stranded DNA binding), GO:0019901 (protein kinase binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0051059 (NF-kappaB binding), GO:0001046 (core promoter sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0042221 (response to chemical), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0009628 (response to abiotic stimulus), GO:0019222 (regulation of metabolic process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0007017 (microtubule-based process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0090068 (positive regulation of cell cycle process), GO:0043487 (regulation of RNA stability), GO:0044085 (cellular component biogenesis), GO:0051129 (negative regulation of cellular component organization), GO:0060548 (negative regulation of cell death), GO:0009314 (response to radiation), GO:0080134 (regulation of response to stress), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0032886 (regulation of microtubule-based process), GO:0010948 (negative regulation of cell cycle process), GO:0045184 (establishment of protein localization), GO:0044087 (regulation of cellular component biogenesis), GO:0045787 (positive regulation of cell cycle), GO:0051726 (regulation of cell cycle), GO:0009894 (regulation of catabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0046907 (intracellular transport), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0071214 (cellular response to abiotic stimulus), GO:0090398 (cellular senescence), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0045786 (negative regulation of cell cycle), GO:0051128 (regulation of cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0007098 (centrosome cycle), GO:0010564 (regulation of cell cycle process), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044092 (negative regulation of molecular function), GO:0008285 (negative regulation of cell population proliferation), GO:0080135 (regulation of cellular response to stress), GO:0051649 (establishment of localization in cell), GO:0000226 (microtubule cytoskeleton organization), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0104004 (cellular response to environmental stimulus), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0006139 (nucleobase-containing compound metabolic process), GO:1901698 (response to nitrogen compound), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031023 (microtubule organizing center organization), GO:0071705 (nitrogen compound transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0043488 (regulation of mRNA stability), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0046599 (regulation of centriole replication), GO:0006886 (intracellular protein transport), GO:0090304 (nucleic acid metabolic process), GO:0015031 (protein transport), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0006259 (DNA metabolic process), GO:0046605 (regulation of centrosome cycle), GO:0043933 (protein-containing complex organization), GO:0051252 (regulation of RNA metabolic process), GO:0010824 (regulation of centrosome duplication), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0071478 (cellular response to radiation), GO:0043086 (negative regulation of catalytic activity), GO:0009416 (response to light stimulus), GO:0034250 (positive regulation of amide metabolic process), GO:1901989 (positive regulation of cell cycle phase transition), GO:0051052 (regulation of DNA metabolic process), GO:0071310 (cellular response to organic substance), GO:0006974 (cellular response to DNA damage stimulus), GO:0006446 (regulation of translational initiation), GO:0051336 (regulation of hydrolase activity), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0051248 (negative regulation of protein metabolic process), GO:1901699 (cellular response to nitrogen compound), GO:0006325 (chromatin organization), GO:0010628 (positive regulation of gene expression), GO:1902115 (regulation of organelle assembly), GO:0010826 (negative regulation of centrosome duplication), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0010639 (negative regulation of organelle organization), GO:0051254 (positive regulation of RNA metabolic process), GO:0046606 (negative regulation of centrosome cycle), GO:0034248 (regulation of amide metabolic process), GO:1901987 (regulation of cell cycle phase transition), GO:0031326 (regulation of cellular biosynthetic process), GO:0043331 (response to dsRNA), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0033043 (regulation of organelle organization), GO:0008104 (protein localization), GO:0014070 (response to organic cyclic compound), GO:0051338 (regulation of transferase activity), GO:0031329 (regulation of cellular catabolic process), GO:0006996 (organelle organization), GO:0032069 (regulation of nuclease activity), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0060700 (regulation of ribonuclease activity), GO:0032070 (regulation of deoxyribonuclease activity), GO:0042981 (regulation of apoptotic process), GO:0051493 (regulation of cytoskeleton organization), GO:0061013 (regulation of mRNA catabolic process), GO:0051494 (negative regulation of cytoskeleton organization), GO:0065003 (protein-containing complex assembly), GO:0031400 (negative regulation of protein modification process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006281 (DNA repair), GO:0051092 (positive regulation of NF-kappaB transcription factor activity), GO:0007010 (cytoskeleton organization), GO:0042254 (ribosome biogenesis), GO:0006338 (chromatin remodeling), GO:1902749 (regulation of cell cycle G2/M phase transition), GO:0043549 (regulation of kinase activity), GO:0051348 (negative regulation of transferase activity), GO:0009411 (response to UV), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:1902680 (positive regulation of RNA biosynthetic process), GO:1903311 (regulation of mRNA metabolic process), GO:0070925 (organelle assembly), GO:0006913 (nucleocytoplasmic transport), GO:0031399 (regulation of protein modification process), GO:0071824 (protein-DNA complex subunit organization), GO:0043066 (negative regulation of apoptotic process), GO:0006355 (regulation of DNA-templated transcription), GO:0071359 (cellular response to dsRNA), GO:0071407 (cellular response to organic cyclic compound), GO:0019220 (regulation of phosphate metabolic process), GO:1902751 (positive regulation of cell cycle G2/M phase transition), GO:0071482 (cellular response to light stimulus), GO:0006417 (regulation of translation), GO:0006334 (nucleosome assembly), GO:0045936 (negative regulation of phosphate metabolic process), GO:0045727 (positive regulation of translation), GO:0010608 (post-transcriptional regulation of gene expression), GO:0001932 (regulation of protein phosphorylation), GO:0034728 (nucleosome organization), GO:0042326 (negative regulation of phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0065004 (protein-DNA complex assembly), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0042255 (ribosome assembly), GO:0045893 (positive regulation of DNA-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)