Protein: Cytochrome b-245 heavy chain (A0A9K3Y6N7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR000778: Cytochrome b245, heavy chain (family) [104-546]
- IPR050369: Respiratory burst oxidase/Ferric reductase (family) [7-570]
- IPR013121: Ferric reductase, NAD binding domain (domain) [401-550]
- IPR013112: FAD-binding 8 (domain) [295-394]
- IPR017938: Riboflavin synthase-like beta-barrel (homologous_superfamily) [286-393]
- IPR013130: Ferric reductase transmembrane component-like domain (domain) [79-219]
- IPR017927: FAD-binding domain, ferredoxin reductase-type (domain) [287-397]
- IPR039261: Ferredoxin-NADP reductase (FNR), nucleotide-binding domain (homologous_superfamily) [390-570]
Sequence:
MGNWAVNEGLSIFVILVWLGLNVFLFVKYYKVYDDEPKYNYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRIRRQLDRNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVGTSDPYSVALSNIGDKENEEYLNFAREKIKNPEGGLYVAVTRLAGITGIVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTSDSLKEHNLDVCADKIKEWGKIKECPVPKFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPQVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCDNATSLRLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERNNANFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPEALAKTLSKQSISNSESGPRGVHFIFNKENF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0001101 (response to acid chemical), GO:0001666 (response to hypoxia), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009410 (response to xenobiotic stimulus), GO:0070482 (response to oxygen levels), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0001817 (regulation of cytokine production), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0009991 (response to extracellular stimulus), GO:0010035 (response to inorganic substance), GO:1904018 (positive regulation of vasculature development), GO:2000026 (regulation of multicellular organismal development), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0001819 (positive regulation of cytokine production), GO:0071456 (cellular response to hypoxia), GO:0010038 (response to metal ion), GO:0071417 (cellular response to organonitrogen compound), GO:1901652 (response to peptide), GO:1903555 (regulation of tumor necrosis factor superfamily cytokine production), GO:0097305 (response to alcohol), GO:0071229 (cellular response to acid chemical), GO:0043200 (response to amino acid), GO:1901654 (response to ketone), GO:0071453 (cellular response to oxygen levels), GO:0071310 (cellular response to organic substance), GO:1903557 (positive regulation of tumor necrosis factor superfamily cytokine production), GO:1901342 (regulation of vasculature development), GO:0048545 (response to steroid hormone), GO:0045766 (positive regulation of angiogenesis), GO:1901699 (cellular response to nitrogen compound), GO:0010628 (positive regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0043434 (response to peptide hormone), GO:0010243 (response to organonitrogen compound), GO:0071241 (cellular response to inorganic substance), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0036293 (response to decreased oxygen levels), GO:0045765 (regulation of angiogenesis), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0045471 (response to ethanol), GO:0031960 (response to corticosteroid), GO:0071248 (cellular response to metal ion), GO:0036294 (cellular response to decreased oxygen levels), GO:1990776 (response to angiotensin), GO:0046686 (response to cadmium ion), GO:0032680 (regulation of tumor necrosis factor production), GO:0097306 (cellular response to alcohol), GO:1904044 (response to aldosterone), GO:0032760 (positive regulation of tumor necrosis factor production), GO:0071230 (cellular response to amino acid stimulus), GO:0071276 (cellular response to cadmium ion), GO:0051385 (response to mineralocorticoid), GO:0071361 (cellular response to ethanol)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0048471 (perinuclear region of cytoplasm), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0031975 (envelope), GO:1902494 (catalytic complex), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0097038 (perinuclear endoplasmic reticulum), GO:0031967 (organelle envelope), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0098797 (plasma membrane protein complex), GO:0043025 (neuronal cell body), GO:0005794 (Golgi apparatus), GO:0005783 (endoplasmic reticulum), GO:0005635 (nuclear envelope), GO:0097447 (dendritic tree), GO:1990204 (oxidoreductase complex), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0005791 (rough endoplasmic reticulum), GO:0005634 (nucleus)