Protein: Integrin alpha 4 (Mapped) (A6HMK7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR048285: Integrin alpha, second immunoglobulin-like domain (domain) [626-773]
- IPR013519: Integrin alpha beta-propellor (repeat) [39-487]
- IPR028994: Integrin alpha, N-terminal (homologous_superfamily) [38-470]
- IPR013649: Integrin alpha, first immunoglubulin-like domain (domain) [467-624]
- IPR048286: Integrin alpha, third immunoglobulin-like domain (domain) [781-964]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [469-948]
- IPR013517: FG-GAP repeat (repeat) [310-407]
- IPR000413: Integrin alpha chain (family) [252-1011]
- IPR018184: Integrin alpha chain, C-terminal cytoplasmic region, conserved site (conserved_site) [1004-1011]
Sequence:
MAAEAMCRPRPRGVALQEAVMLLLYFGVHFRVPTGHSYNLDPESALLYQGPSGTLFGYSVVLHSHGTKRWLIVGAPTASWLANASVVNPGAIYRCRIGKNPNQICEQLQLGSPSGEPCGKTCLEERDNQWLGVTISRQPGENGSIVTCGHRWKNIFYMKNNNKLPTGVCYGMPSDLRTELSKRMAPCYQDFVRKFGENFASCQAGISSFYTQDLIVMGAPGSSYWTGSVFVYNITTNKYKAFVDRQNQVKFGSYLGYSVGAGHFRNPHTTEVVGGAPQHEQIGKAYIFSIDESELTIVYEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGMGAVMVEMERVLVGSDKYAARFGESMANLGDIDNDGFEDIAIGAPQEDDLRGAVYIYNGRVDGISSTYSQRIEGRQISQSLRMFGQSISGQIDADNNGYVDVAVGAFQSDSAVLLRTRPVVIVEASLSHPESVNRTKFDCTENGLLSVCVDLKLCFSYKGKEVPGYIVLFYNVSLDVHRKAESPSRFYFFSNGTSDMITRSIRVSSSGEKCRTHQAFMRKDVRDILTPIQVEATYHLGHHVITKRNTEEFPPLQPILQQKKEKDIIRKTINFARFCAYENCSADLQVSAKVGFLKPYENKTYLAVGSMKTIMLNVSLFNAGDDAYETTLNVQLPTGLYFIKILDLEEKQINCDVTESSGVVKLACSLGYIYVDRLSRIDISFLLDVSSLSRAHEDLSINVHASCENEGKLDQVKDNRVTLVIPLRYEVMLAVHGFVTPTSFVYGSSEENEPEMCMAEKLNLTFHVINTGISMAPNVSVKIMVPNSFLPRNDKLFNVLDVQATMGQCQFEHYGRECALAQQKGIAGTLTDLVKFLSKTDKRLLYCMKADRHCLDFLCNFGKMESGKEASVHIQLEGRPSVLEMDETSSLKFEIKATAFPEPHPKVIELNKDENIAHVYLEGLHHQRPKRHFTIVIVTISLLLGLIVLLLISCVMWKAGFFKRQYKSILQEENRRDSWSYVNSKSNDD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003823 (antigen binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding), GO:0001968 (fibronectin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048589 (developmental growth), GO:0051641 (cellular localization), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0002684 (positive regulation of immune system process), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0060384 (innervation), GO:0016049 (cell growth), GO:0050900 (leukocyte migration), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051640 (organelle localization), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0021675 (nerve development), GO:0060385 (axonogenesis involved in innervation), GO:2000145 (regulation of cell motility), GO:0002685 (regulation of leukocyte migration), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0030155 (regulation of cell adhesion), GO:0051649 (establishment of localization in cell), GO:0045785 (positive regulation of cell adhesion), GO:0051648 (vesicle localization), GO:0010033 (response to organic substance), GO:2000147 (positive regulation of cell motility), GO:0002687 (positive regulation of leukocyte migration), GO:0000902 (cell morphogenesis), GO:0048588 (developmental cell growth), GO:0051656 (establishment of organelle localization), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0016043 (cellular component organization), GO:0045123 (cellular extravasation), GO:0016477 (cell migration), GO:0034097 (response to cytokine), GO:0030030 (cell projection organization), GO:0022409 (positive regulation of cell-cell adhesion), GO:0071310 (cellular response to organic substance), GO:0022407 (regulation of cell-cell adhesion), GO:0032990 (cell part morphogenesis), GO:0030334 (regulation of cell migration), GO:0051650 (establishment of vesicle localization), GO:0048666 (neuron development), GO:0022008 (neurogenesis), GO:0098657 (import into cell), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0002691 (regulation of cellular extravasation), GO:0071677 (positive regulation of mononuclear cell migration), GO:0030335 (positive regulation of cell migration), GO:0016192 (vesicle-mediated transport), GO:0071675 (regulation of mononuclear cell migration), GO:0048858 (cell projection morphogenesis), GO:1990138 (neuron projection extension), GO:0030182 (neuron differentiation), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:1903236 (regulation of leukocyte tethering or rolling), GO:2000401 (regulation of lymphocyte migration), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0071345 (cellular response to cytokine stimulus), GO:2000403 (positive regulation of lymphocyte migration), GO:0006897 (endocytosis), GO:0031175 (neuron projection development), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:0048699 (generation of neurons), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:2000406 (positive regulation of T cell migration), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0006898 (receptor-mediated endocytosis), GO:1904996 (positive regulation of leukocyte adhesion to vascular endothelial cell), GO:1904994 (regulation of leukocyte adhesion to vascular endothelial cell), GO:2000404 (regulation of T cell migration), GO:0007409 (axonogenesis), GO:0072583 (clathrin-dependent endocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0005615 (extracellular space), GO:0030427 (site of polarized growth), GO:0009986 (cell surface), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0005576 (extracellular region), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0030426 (growth cone), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0043005 (neuron projection), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle), GO:0030424 (axon)