Protein: Lysoplasmalogenase TMEM86A (Q9D8N3)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen . Plays an important role in lysoplasmalogen metabolism in the adipocyte tissue and macrophages
Subcellular location: Endoplasmic reticulum membrane ; Multi-pass membrane protein
InterPro domains:
- IPR012506: Lysoplasmalogenase-like (family) [6-239]
Sequence:
MVSPVTVVKSEGPKLVPFFKATCVYFVLWLPSSSPSWVSALIKCLPIFCLWLFLLAHGVRFLLAHPSASLIFVGLVFSAVGDAFLIWQDHGYFEHGLLMFAVAHILYAAAFGMRPLALRTGLVIGVLSGLCYALLYPGLSGAFTYLVGVYVALISFMGWRAMAGLRLVGAAWRWTELAAGGGALLFILSDLTIALNKFCFPVPYSRALIMSTYYAAQMLIALSAVESREPVGEDYRLSKAD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016801 (hydrolase activity, acting on ether bonds), GO:0016803 (ether hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0009892 (negative regulation of metabolic process), GO:0048878 (chemical homeostasis), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0120161 (regulation of cold-induced thermogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0044255 (cellular lipid metabolic process), GO:0051649 (establishment of localization in cell), GO:0044249 (cellular biosynthetic process), GO:0005975 (carbohydrate metabolic process), GO:0120162 (positive regulation of cold-induced thermogenesis), GO:0031324 (negative regulation of cellular metabolic process), GO:0060041 (retina development in camera-type eye), GO:0043170 (macromolecule metabolic process), GO:0060249 (anatomical structure homeostasis), GO:1901135 (carbohydrate derivative metabolic process), GO:0010876 (lipid localization), GO:0009991 (response to extracellular stimulus), GO:0009894 (regulation of catabolic process), GO:0006629 (lipid metabolic process), GO:0009888 (tissue development), GO:0040014 (regulation of multicellular organism growth), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009895 (negative regulation of catabolic process), GO:0050877 (nervous system process), GO:0001894 (tissue homeostasis), GO:0080090 (regulation of primary metabolic process), GO:0030282 (bone mineralization), GO:0044260 (cellular macromolecule metabolic process), GO:0071496 (cellular response to external stimulus), GO:0006091 (generation of precursor metabolites and energy), GO:0044262 (cellular carbohydrate metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0051216 (cartilage development), GO:0048705 (skeletal system morphogenesis), GO:0071705 (nitrogen compound transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0048880 (sensory system development), GO:0061448 (connective tissue development), GO:0007423 (sensory organ development), GO:0016051 (carbohydrate biosynthetic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:0071702 (organic substance transport), GO:0006638 (neutral lipid metabolic process), GO:0043588 (skin development), GO:1903018 (regulation of glycoprotein metabolic process), GO:0045017 (glycerolipid biosynthetic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0042461 (photoreceptor cell development), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0050905 (neuromuscular process), GO:0048568 (embryonic organ development), GO:0060348 (bone development), GO:0007399 (nervous system development), GO:0010508 (positive regulation of autophagy), GO:0001501 (skeletal system development), GO:0009100 (glycoprotein metabolic process), GO:0031667 (response to nutrient levels), GO:0090207 (regulation of triglyceride metabolic process), GO:0002062 (chondrocyte differentiation), GO:0005976 (polysaccharide metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0050994 (regulation of lipid catabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:1903509 (liposaccharide metabolic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0008104 (protein localization), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0060429 (epithelium development), GO:0019216 (regulation of lipid metabolic process), GO:0006996 (organelle organization), GO:0045444 (fat cell differentiation), GO:0008610 (lipid biosynthetic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0072657 (protein localization to membrane), GO:0046463 (acylglycerol biosynthetic process), GO:0001654 (eye development), GO:0031399 (regulation of protein modification process), GO:0006112 (energy reserve metabolic process), GO:0000271 (polysaccharide biosynthetic process), GO:0098773 (skin epidermis development), GO:0048884 (neuromast development), GO:0019220 (regulation of phosphate metabolic process), GO:0150063 (visual system development), GO:0007519 (skeletal muscle tissue development), GO:1903725 (regulation of phospholipid metabolic process), GO:0008654 (phospholipid biosynthetic process), GO:0030198 (extracellular matrix organization), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0051205 (protein insertion into membrane), GO:0009101 (glycoprotein biosynthetic process), GO:0031401 (positive regulation of protein modification process), GO:0045936 (negative regulation of phosphate metabolic process), GO:0042632 (cholesterol homeostasis), GO:0005977 (glycogen metabolic process), GO:0035303 (regulation of dephosphorylation), GO:0046488 (phosphatidylinositol metabolic process), GO:0006641 (triglyceride metabolic process), GO:0042326 (negative regulation of phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)