Protein: Rho guanine nucleotide exchange factor 7 isoform X1 (A0A8M6Z5N5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, lamellipodium
InterPro domains:
- IPR000219: Dbl homology domain (domain) [249-429]
- IPR001849: Pleckstrin homology domain (domain) [451-558]
- IPR001452: SH3 domain (domain) [162-221]
- IPR046376: RhoGEF 6/7, PH domain (domain) [458-557]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [240-439]
- IPR036872: CH domain superfamily (homologous_superfamily) [1-115]
- IPR032409: Rho guanine nucleotide exchange factor 6/7, coiled-coil domain (domain) [772-855]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [163-237]
- IPR001715: Calponin homology domain (domain) [1-110]
- IPR001331: Guanine-nucleotide dissociation stimulator, CDC24, conserved site (conserved_site) [377-402]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [436-562]
Sequence:
MNSAEQTITWLITLGVLESPKKTLSDPEGFLQASLRDGVVLCKLLERLRPGSVHTIYQDPRKDECLSNIREFVKGCALYHIEVFEANDLLQGQNFSKVLNCLVALNKATSESGGGSNSVCSRQSSSLRIKSFDSLNCSSTHRRSSRHKFNQYRSLDMSENSAPQVLVKARFNFQQTNEDELSFSKGDIIQVTRQEEGGWWEGALNGKTGWFPSNYVKEIKGSDKPVSPKTGTLKSPPKAIESANFCKTYYNVVVQNILQTETEYCKELQNLLSVYLRALQPTDRLSVSDISHIMGNLEEISSFQQTLVHSLEENVKVSDSQQRIGGFFLSLLTQMRSLYVTYCSNHPSAVNVLTQHSEELGEFMESKGANTPGILTLTTGLSKPFLRLEKYPTLLKEMERHMEPLHPDYPDIQKSMTLFKNLSAQCQEVRKRKELELQILMESIRGWEGEGIKTLGTVLFMSQVIIQNHGAEEKNERYLLLFPHILLMLSASPRMSGFIYQGKLPLTGMSVSKTEDSDGTKHAFEISGNMIERIQVICNNQQDLQDWVDHLHRQTKRISTSSLKPQSVPCHTLPSHPLTPSRHSESRGVSGSPVYHTLPHLSSLGTPHSGMMWGPLEPPKTQKPWSLSCLRPAPPLKPSAALCYKEDLSKSPKNMKKLLPKRKPERKPSDEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADVHQSCVDAVGCRSSGFPSSDQSEDSDYDSIWITHTNRIGSVSRSRKESGPHMLFPEEEKIIVEETKSNGQTVIEERSLVDTVYALRDEVQELKQDNKRMKRTLEEEQKARKELEKVVRRVLKSMNDPSWDETNL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0019899 (enzyme binding), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0019900 (kinase binding), GO:0030695 (GTPase regulator activity), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0008283 (cell population proliferation), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0033036 (macromolecule localization), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0050673 (epithelial cell proliferation), GO:0070727 (cellular macromolecule localization), GO:0009790 (embryo development), GO:0035239 (tube morphogenesis), GO:0055113 (epiboly involved in gastrulation with mouth forming second), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0007369 (gastrulation), GO:0002009 (morphogenesis of an epithelium), GO:0008104 (protein localization), GO:0060429 (epithelium development), GO:0001935 (endothelial cell proliferation), GO:0002011 (morphogenesis of an epithelial sheet), GO:0001702 (gastrulation with mouth forming second), GO:1902414 (protein localization to cell junction), GO:0150105 (protein localization to cell-cell junction), GO:0090504 (epiboly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)