Protein: Plectin (A0A8I5KUE3)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR041615: Desmoplakin, SH3 domain (domain) [770-836]
- IPR041573: Desmoplakin, spectrin-like domain (domain) [871-948]
- IPR001452: SH3 domain (domain) [781-838]
- IPR018159: Spectrin/alpha-actinin (repeat) [259-1347]
- IPR001101: Plectin repeat (repeat) [2666-4437]
- IPR036872: CH domain superfamily (homologous_superfamily) [3-243]
- IPR049538: Plectin-like, spectrin-like repeat (repeat) [367-466]
- IPR035915: Plakin repeat superfamily (homologous_superfamily) [2614-4460]
- IPR001589: Actinin-type actin-binding domain, conserved site (conserved_site) [21-118]
- IPR043197: Plakin (family) [122-2070]
- IPR001715: Calponin homology domain (domain) [19-240]
Sequence:
MDRYSMEELIQLGQDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0005200 (structural constituent of cytoskeleton), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding), GO:0008092 (cytoskeletal protein binding), GO:0045296 (cadherin binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0032879 (regulation of localization), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0045927 (positive regulation of growth), GO:0051050 (positive regulation of transport), GO:0033036 (macromolecule localization), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051094 (positive regulation of developmental process), GO:0040008 (regulation of growth), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0048639 (positive regulation of developmental growth), GO:0045597 (positive regulation of cell differentiation), GO:0048638 (regulation of developmental growth), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:2000145 (regulation of cell motility), GO:0032388 (positive regulation of intracellular transport), GO:0060341 (regulation of cellular localization), GO:0001558 (regulation of cell growth), GO:0030155 (regulation of cell adhesion), GO:0051130 (positive regulation of cellular component organization), GO:0032886 (regulation of microtubule-based process), GO:0030307 (positive regulation of cell growth), GO:0051668 (localization within membrane), GO:0010033 (response to organic substance), GO:0044087 (regulation of cellular component biogenesis), GO:2000026 (regulation of multicellular organismal development), GO:0070887 (cellular response to chemical stimulus), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0070727 (cellular macromolecule localization), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051222 (positive regulation of protein transport), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0090066 (regulation of anatomical structure size), GO:0032535 (regulation of cellular component size), GO:0034097 (response to cytokine), GO:0043254 (regulation of protein-containing complex assembly), GO:0090316 (positive regulation of intracellular protein transport), GO:0045773 (positive regulation of axon extension), GO:0031344 (regulation of cell projection organization), GO:0010810 (regulation of cell-substrate adhesion), GO:0071310 (cellular response to organic substance), GO:1904951 (positive regulation of establishment of protein localization), GO:1901888 (regulation of cell junction assembly), GO:0070201 (regulation of establishment of protein localization), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0050769 (positive regulation of neurogenesis), GO:0032880 (regulation of protein localization), GO:0051960 (regulation of nervous system development), GO:0030334 (regulation of cell migration), GO:0150116 (regulation of cell-substrate junction organization), GO:1905477 (positive regulation of protein localization to membrane), GO:0001578 (microtubule bundle formation), GO:0061387 (regulation of extent of cell growth), GO:0050770 (regulation of axonogenesis), GO:0072657 (protein localization to membrane), GO:0051223 (regulation of protein transport), GO:0031346 (positive regulation of cell projection organization), GO:0016482 (cytosolic transport), GO:0030335 (positive regulation of cell migration), GO:0033043 (regulation of organelle organization), GO:0008104 (protein localization), GO:1901701 (cellular response to oxygen-containing compound), GO:0032386 (regulation of intracellular transport), GO:0051493 (regulation of cytoskeleton organization), GO:1905475 (regulation of protein localization to membrane), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0071300 (cellular response to retinoic acid), GO:0050772 (positive regulation of axonogenesis), GO:0001952 (regulation of cell-matrix adhesion), GO:0033157 (regulation of intracellular protein transport), GO:1990778 (protein localization to cell periphery), GO:1902473 (regulation of protein localization to synapse), GO:0071345 (cellular response to cytokine stimulus), GO:0071396 (cellular response to lipid), GO:0090109 (regulation of cell-substrate junction assembly), GO:0034612 (response to tumor necrosis factor), GO:0072659 (protein localization to plasma membrane), GO:0042307 (positive regulation of protein import into nucleus), GO:1904375 (regulation of protein localization to cell periphery), GO:1903078 (positive regulation of protein localization to plasma membrane), GO:1903076 (regulation of protein localization to plasma membrane), GO:0051893 (regulation of focal adhesion assembly), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0043229 (intracellular organelle), GO:0070161 (anchoring junction), GO:0043228 (non-membrane-bounded organelle), GO:0030055 (cell-substrate junction), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0005925 (focal adhesion), GO:0045111 (intermediate filament cytoskeleton)