Protein: Sterol regulatory element-binding protein cleavage-activating protein (A0A8M2B4M5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR057042: SCAP, beta-propeller (domain) [794-1285]
- IPR030225: Sterol regulatory element-binding protein cleavage-activating protein (family) [51-1294]
- IPR057041: SCAP, N-terminal (domain) [127-319]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [767-1288]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [796-1257]
- IPR053958: HMGCR/SNAP/NPC1-like, sterol-sensing domain (domain) [350-493]
- IPR019775: WD40 repeat, conserved site (conserved_site) [1148-1162]
- IPR001680: WD40 repeat (repeat) [789-1241]
- IPR000731: Sterol-sensing domain (domain) [326-484]
Sequence:
MYQTTMSSTISYVAVPMSYDRIISLDARRCPRPGRTRRLDGHQLTPAPRMTVRERLRQNISAAFYRHGLLCASYPVPIILFTSASILTCCYPLLKLPLPGTGPVEFTTGVRDYSIPSHESQGDLSERPDWYRGPPVAYIQQVLVKAAVSPWGNSLVPVDVFRSPLGRVFSLLDEIRNHVYTDRSLEALCLQVTDLLPGLRRMQAVLPEHGCLLVSPGNYWQNRRDLFDADPDLLKTVHQHEPKGLHTSATLRDLLFGVPGKQTGVSLYSKKRVVTYTVTIALSSYDARFVGSLRARLKQLHPSANCTLREDHMVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVRSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSNESWSIMKNMATELCIILIGYFTFVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADLNRRLPAEAGMPPPKPGTLRPRETPPPPRPSPHTITLQTPAFRNLRLPKRLRVVYFLARTRLAQRIIMVGTVIWIGILVYTDPAGLRTFLAAQVSEQSPLGEAGLPPHLGVAPVFPGGHPTSTLSVLPAPEPTPLPENQSQGHRAARPGVAPVSSPQITWGSEDEELWRRLSFRHWPSLFSYYNITLAKRYISILPVIPVTLHLSPQEAIDTRHPQDTQHAPPPPPSIKTSDLQTDLTLYKVAALGLFAGVLLVLLLFCLYRVLCPRNYGQNGVPHGRRRRGDLPCDEYGYSPPISEISPLLLRGHSMDIECLASDGMLLASCCLAGQIRVWDAQTGDCLTVIPNKGLRRSSSNGCWEHRDGWDHISAFEVEGIATDFREPGGAMGGPDVDIFAIRRRTTPARPALFGDQPDLTPLIDTNFGALPPSQALSGSGFDFGSLVEKAYQEHEPSPVLVFPPSPPASQQRRRSLGDQPVLPPELPPQSSADWDSSVWAMELRGNLIATGRSTGKLELWDAVEGSLRCSNEDGVSGITALAFLNNRIVAARLNGSLDFFTVEINKPLGLLQYRGPPGRGSLPPSPCYSSEDVISCHLTRSVQCAHQKPITVLKAAAGRVVTGSQDHTVRVYRLEDSCCLFTLQGHSGGITAIYIDQTMVLASGGQDGAICVWDVLTGSRVSHVYGHRGDVTSLVCTTSCIISSGLDDLICIWDRSTGIKLYSIQQEVGCGASLGVISENLLVTGGQGCVSFWDLNYGDLLQTVYLGPSSEGQSVRQLLVLDNAAIICDFGSELSLVYVPSVLEKLD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0043178 (alcohol binding), GO:0005496 (steroid binding), GO:0032934 (sterol binding), GO:0015485 (cholesterol binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0044238 (primary metabolic process), GO:0051235 (maintenance of location), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0019915 (lipid storage), GO:0006629 (lipid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0031975 (envelope), GO:0012505 (endomembrane system), GO:0005643 (nuclear pore), GO:0043229 (intracellular organelle), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)