Protein: 7-dehydrocholesterol reductase (B4E1K5)
Organism: Homo sapiens (Human)
Function: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7- dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien- 3beta-ol, two intermediates in that pathway
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR001171: Sterol biosynthesis ERG24/DHCR-like (family) [15-280]
- IPR018083: Sterol reductase, conserved site (conserved_site) [18-267]
Sequence:
MVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0016628 (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0006807 (nitrogen compound metabolic process), GO:0042445 (hormone metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0010817 (regulation of hormone levels), GO:0008209 (androgen metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0035383 (thioester metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0043603 (amide metabolic process), GO:1901575 (organic substance catabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0043436 (oxoacid metabolic process), GO:0008202 (steroid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0035384 (thioester biosynthetic process), GO:0046165 (alcohol biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006631 (fatty acid metabolic process), GO:0016054 (organic acid catabolic process), GO:0006637 (acyl-CoA metabolic process), GO:0044272 (sulfur compound biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0030258 (lipid modification), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901568 (fatty acid derivative metabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0009117 (nucleotide metabolic process), GO:0035337 (fatty-acyl-CoA metabolic process), GO:0034032 (purine nucleoside bisphosphate metabolic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0046395 (carboxylic acid catabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0033865 (nucleoside bisphosphate metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0006633 (fatty acid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0046390 (ribose phosphate biosynthetic process), GO:0019395 (fatty acid oxidation), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:0071616 (acyl-CoA biosynthetic process), GO:1901570 (fatty acid derivative biosynthetic process), GO:0009062 (fatty acid catabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009260 (ribonucleotide biosynthetic process), GO:0034033 (purine nucleoside bisphosphate biosynthetic process), GO:0046949 (fatty-acyl-CoA biosynthetic process), GO:0034033 (purine nucleoside bisphosphate biosynthetic process), GO:0046949 (fatty-acyl-CoA biosynthetic process), GO:0033875 (ribonucleoside bisphosphate metabolic process), GO:0035336 (long-chain fatty-acyl-CoA metabolic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0009165 (nucleotide biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0006164 (purine nucleotide biosynthetic process), GO:0072329 (monocarboxylic acid catabolic process), GO:0033866 (nucleoside bisphosphate biosynthetic process), GO:0035338 (long-chain fatty-acyl-CoA biosynthetic process), GO:0034030 (ribonucleoside bisphosphate biosynthetic process), GO:0009152 (purine ribonucleotide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)