Protein: A1 cistron-splicing factor aar2 (Q6LA53)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth (By similarity)
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR038516: AAR2, N-terminal domain superfamily (homologous_superfamily) [6-124]
- IPR007946: A1 cistron-splicing factor, AAR2 (family) [5-316]
- IPR038514: AAR2, C-terminal domain superfamily (homologous_superfamily) [132-339]
- IPR033648: AAR2, C-terminal domain (domain) [148-308]
- IPR033647: AAR2, N-terminal (domain) [1-111]
Sequence:
MSIEFVGWLNTYYVGIDQSSYEASKLPGIRNVKGGIHLFTWSPTYPAGLISGVFAMVHEDMKYSIDFDSKSETASLQKLDVLYDENFYPFESTKDWDLLTKFITVQDLQRIFATEGEFFYLDTSTYVNADLVSQDPEFSKPSRDDKLLNFAEFNLRRSWSPSATGPERSKQAIDKSFLFQRLVQSVWNDNPISALAELSISFLSYSILSHYGALEHWKNMLSLLLQSYELAETEPEFYASFLELFKLQLSSLSESDLETSAIFEKGVLLSCLDSLSERKVDGSFGSLVNEAIENLLKTISELLNSHEEQAGLMQKGDLYSAADYEAEVHETGDYVIDVSTEEDPIH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0043933 (protein-containing complex organization), GO:0010467 (gene expression), GO:0022607 (cellular component assembly), GO:0016070 (RNA metabolic process), GO:0022618 (ribonucleoprotein complex assembly), GO:0065003 (protein-containing complex assembly), GO:0006396 (RNA processing), GO:0071826 (ribonucleoprotein complex subunit organization), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000387 (spliceosomal snRNP assembly), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)