lokahq/bioreason-rl huggingface dataset:
Protein: Collagen alpha-1(XIV) chain isoform X6 (A0A8M9PDJ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
Sequence:
MQVSGSRIKLWCPLISLALIQFLAPVSAQVDQFVCTTPAIADIVILVDGSWSIGRINFRLVRMFLENLVNAFDVGIDKTRIGLAQYSGDPRIEWHLNGFSTKEAVIDAVKNLPYKGGNTLTGLALTYVLENSFKPESGARDNIPKIGILITDGKSQDDVISPAQTLRSSGVELFAIGVKNADENELKAIASEPEDTHVYNVADFSIMGTIVEGLTRTVCDGVEQQDKEIKQDSVPEETVSTPLNLLISEVTAHSFRVSWTHSAGKVEKYRVVYHPTDADIPEEIVVGGLENSVVLQNLNSLTEYEIAVFAVYRSAASDALRGSEITQALPTVSDLELYDVTDSSMRARWRDAEGASGYMILYAPLSSDTPDERELKVDETVTDVELTGLIPDTEYTVTVYATFGEEASDPATVQETTMSLKPPRNLRVTEVDHSSVRLNWDSASSKVKGYQVIYVKTDGVQTNQVELGPVTNVYLKNLSPLTEYTVAVFAVYDGGQSEALSGGFSTKLVPAPFSLMTSDVTSESFQVSWSHPARDVVLYKLIWSPTAGRDEREVMLAGDTDSYVIQDLSPFTEYKVSLAAIYKDETESSPVVVLEYTLGWTTEFPTTIPTTTPIFHQGVTNLWIDEETPFSIQVNWEVQDSDVDQYKVTYVSTDRTEETVLVSGNRRNVVLQPLLSDTKYKITVTPVYADEESSQLSMSSFGTTLPLSGPSNLRVSDEWYNRFRISWDSPQFPTMGYRVIYQPISVSGRALETFVGDDVNTLLILNLLSDTEYSVQVIASYTTGSSQPLTAKGKTLFLGVRNLNTYQVLSSSVCAQWQPHRHASVYRVVIESLHNGQKQEVRVGGGASRECFFRLSPNTQYKISVYTVLQDTEGPAVTTMVTTALAPTQPPTAAPTTSPPPTIPPAKEVCKAAKADLTFLVDGSWSIGDDNFQKIIRFLYSTTGALDVIGPEGTQVAIAQFSDDARTEFKLNSYSDKEALLDAVQRISYKGGNTKTGRAIKHVKEAIFSEDAGVRRGIPKVLVVLTDGRSQDDVNKISKEMQMEGYIIFAIGFADADYGELVNIASKPSERHVFFVDDLDAFKKIEEQLITFVCEAATATCPSVLMSGNTLAGFRMMEMFGLAEKHYSSVQGVSMEPGTFNSFPCYRLHKDALVSQPTRYLHPEGLPSDYTISMLFRILPETPQEPFALWEILDKNNEPLVGIILDNGGKTLTFFNSDYKGEFQTVTFEGPEIKKIFYGSFHKLHVAISKTAAKVVIDCKTVGEKSINAAGNISIDGVEVLGRMVRSRGRKDNSAPFQLQMFDIVCSTSWASRDKCCELPGLRVEEDCPAMPHACTCAQDSKGPPGPSGPPGGPGIRGSRGDRGEPGLTETAGHSHFVSAARLVGSQGLPGEIGPPGPQGPPGPQGPNGLSIQGPPGAPGEKGDKGEIGLPGPQGVPGANGGPGRDGPPGQRGLPGKDGPQGRQGPPGPMGSPGAPGAPGSNGPPGQLGDQGPPGPAGTKGERGERGDMQSHAAVRAIARQVCEQLIQSHLSRYNSILNQIPSQSVSVRTVPGPPGEPGRPGLQGPQGEQGPPGRPGFPGASGQNGRPGERGLPGERGEKGSPGVGTQGPRGPPGSPGPAGEGRTGSQGPPGRPGIQGTQGRPGTPGSPGPAGPPGYCDQNSCLGYNVGVQQLSSNPYQNYGPATNYNPEDEEEDDPYGGYRAYPPQYYQPSYPDPRGARPGPVHPGDTAGMRAPGARRFTRSTAEEGIVHQPQEHVKEEELW
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization), GO:0070206 (protein trimerization), GO:0070207 (protein homotrimerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix)
Protein: Homeobox protein Meis2 isoform X7 (A0A8M3AUM6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
- IPR008422: KN homeodomain (domain) [289-328]
- IPR032453: Homeobox protein PKNOX/Meis, N-terminal (domain) [69-182]
- IPR001356: Homeodomain (domain) [269-336]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [270-343]
- IPR050224: Three Amino acid Loop Extension (TALE) homeobox (family) [58-341]
Sequence:
MAQRYDELAHYGGMDGVGMYGDPHAPRPLPQVHHLNHGPPLHASQHYGTHAPHPNVMPTSMGSAVNDVLKRDKDQIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPASWRDHDDATSTHSAGTPGPSSGGLASQSGDNSSEQDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:1904888 (cranial skeletal system development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0048703 (embryonic viscerocranium morphogenesis), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Carboxypeptidase A6 isoform X2 (A0A8M3AW04)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
Sequence:
MQVDLWQPNSASLIRENSSIDVHVRRDKTHWLRNHLHQEHIYYEVLISNLQTEIEKQTGYRSSRKRRSELQYDYEVYHPLEEIQSWMFEMNRTHSHLVDLFSIGQSYEGRPLYVLQLGKRTRFFKKAVWIDCGVHAREWIGPAFCQWFVKEALNSYQHDSSMRRLMNQLNFYIMPVFNVDGYHYSWKMDRFWRKTRSKIPKYHCRGVDANRNWKVKWCDEGASLHPCDDTYCGPFPESEPEVKAVAKFLRKHKKRVKAYISMHAYAQMLLYPYSYKYATIPNFNCVESAAQNAVSALYSAYGVRYRYGPASSTLYVSSGSSMDWAYKNGIPYAFAFELRDTGYYGFLLPEALINPTCTETMRAVKTIASGLLRKCTK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008238 (exopeptidase activity), GO:0004180 (carboxypeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Myosin-binding protein C, fast-type isoform X5 (A0A8M9P5V8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR003961: Fibronectin type III (domain) [596-988]
- IPR013098: Immunoglobulin I-set (domain) [21-1094]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [9-1096]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [594-978]
- IPR003598: Immunoglobulin subtype 2 (domain) [226-1084]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [21-1098]
- IPR007110: Immunoglobulin-like domain (domain) [10-1093]
- IPR040849: MyBP-C, tri-helix bundle domain (domain) [169-202]
- IPR003599: Immunoglobulin domain subtype (domain) [25-1095]
- IPR050964: Striated Muscle Structural and Regulatory Protein (family) [403-1088]
Sequence:
MPEPTEEVKPEVEPTELTGLFVEKPESVVAIAGKDVTFVVKVDSTNLTRKPTMKWLKGKWMDLGSKAGKHIQLKETYDRNTKIYTYEMKLVKVVPGDAGGYRCEVSAKDKCDSCTFEVTVEAAEQEQQADILSAFKRADAGEDEGDLDFSALLKAAKKKKKPEPELEVDVWELLKSAHPSEYEKIAFKYGITDLRGMLKRLKKMKVVEPKFSEAFLRRLESAYSVNKGKKIVMSVEVADPNAEVKWLRNGQEIKPSAKYIMEADGNIRTLTINKCSLADDAAYECVVGTDKCFTEVFVKEPPITITKLLDDYHVVVGERVEFEIEVSEEGAHVIWLFEDQQLSREDKDSKYRFKKDGKRHCLIIQEATLEDNGMFYVYTNGGQSKGELIVEEKELEVLQSIADLTVKSAEQAMFKCEVSDEKVTGKWFKDGVEVLPSDRIKISHIGRIHRLTIDDVKPGDAGDYTFVPDGYALSISAKLNFLEIKIDYVPRQDPPKIHLDVSGNMVSQNTIIVVAGNKLRLDVEITGEPAPTVCWMRDDKPVTDSEGRVRVENKKDLSCFIIEGAEREDEGNYTITVTNPAGEDKANLFIKIVDVPDPPENVKCTGVGEDTANIVWDPPKFDGGAPLKGYLMERKKKGSSRWTKLNFDVYESTTYEAKRMIEGILYEMRVFAVNGIGISAPSLNSKPFMPIAPTSEPTKLTVDDVTDTTCSLKWLAPEKIGAGGLDGYIIEFCKEGESEWHPANTDLVERQSFVVRNLPTGEKMNFRVVAVNIAGRSPPALLGQPVTVREIMEHPKIRLPRDLRTKYIRRVGEKINLVIPFQGKPRPIATWLKDGQPVDEKKVGVRNSNVDSILFIRAAERDHSGKYTLTLKIENMEDSATIEIRIVDKPGPPIGVHVTDVWGFNAALEWKPPKDDGNCEITGYTIQKAEKKTKEWFTVYEHNRRTNCTVSDLIIGNEYMFRVYSENLCGLSEDPCMSKNNAIISKSGLDYKPPPYKEKDMNCAPKFTAPLVDRAVTIGYSTAISCAVRAFPKPKIIWMKNKMIIGDDPKFLMQNNQGVLTLNIRKPSTFDSGKYSCRAVNELGEDEVECKLEIKALPIEKKD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0060590 (ATPase regulator activity), GO:0140677 (molecular function activator activity), GO:0001671 (ATPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0060537 (muscle tissue development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030017 (sarcomere), GO:0005737 (cytoplasm), GO:0031672 (A band), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: Proton myo-inositol cotransporter isoform X1 (A0A8M2BA61)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR020846: Major facilitator superfamily domain (domain) [38-550]
- IPR005829: Sugar transporter, conserved site (conserved_site) [334-350]
- IPR005828: Major facilitator, sugar transporter-like (family) [39-561]
- IPR050814: Myo-inositol Transporter (family) [25-576]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [24-567]
- IPR003663: Sugar/inositol transporter (family) [33-497]
Sequence:
MEDQRAYARVEDESTLIKTASKRDHELQPGPPCFVYTLAFFSALGGFLFGYDTGVVSGAMLLLKREKKLSSVWQELLVSITVGAAAVSALAGGFLNGRFGRRVCILLASFIFCAGGIILSVARNKEALLCGRLTVGLGLGIASMTVPVYIAEVSPPDLRGQLVTVNTLFITGGQFIASVVDGAFSYLPHDGWRFMLGLSVVPAALQFLGFLFLPESPRWLLQKGFTQNALLVLRQIRGDVDVEEEFESIRCSIQEEQRDVAGGPVLWRMLASPPARRALIVGCGLQMFQQLAGINTVMYYSATILQMSGVQDDQMAIWLAAGTAFTNFLFTLVGVWLVERVGRRRLTMASLLGTAVSLMVLAAGFLLSAQASPPVTFHPSNPSIHNSTCGNYGFCESCMLDPDCGFCYGLNATAVVQSSCVPVDPANTETAALGRCFNGTQKASSVFWAYNYCPTPYSWVVLLGLILYLAFFAPGMGPMPWTVNSEIYPLWARSTGNACSAGVNWICNVLVSLTFLHVAQYLTYYGAFFLYAALALLGFVFVSGCLPETKGLRLEEIESLFSRRLCSCGAHTDQYMRRLEFGALHYATSEPEGRISYISVSTSQKKTKSLILISVLFHSRKNIEHNIFVLPLHFEFTEEVD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015144 (carbohydrate transmembrane transporter activity), GO:0051119 (sugar transmembrane transporter activity), GO:0015145 (monosaccharide transmembrane transporter activity), GO:0015149 (hexose transmembrane transporter activity), GO:0005355 (glucose transmembrane transporter activity), GO:0055056 (D-glucose transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0015850 (organic hydroxy compound transport), GO:0015798 (myo-inositol transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005802 (trans-Golgi network)
Protein: NLR family CARD domain-containing protein 3-like isoform X2 (A0A8M3AQ77)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR011029: Death-like domain superfamily (homologous_superfamily) [183-274]
- IPR007111: NACHT nucleoside triphosphatase (domain) [357-521]
- IPR004020: DAPIN domain (domain) [193-273]
- IPR041267: NACHT, LRR and PYD domains-containing protein, helical domain HD2 (domain) [670-797]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [275-522]
- IPR051261: NOD-like receptor (family) [247-797]
Sequence:
MSLVAEDSDSDVDRMDRPPSSYGSMHSDDQDEELDYIEDSEPPPARVRLQRPDSPETAITERTHTHQSSIHHSGGVYLTRQSITQEEFRSPAPPTREPTILDQSELQSEIRTEAEMDEEPNDREMDFQDQQNEGSAMEVQEEQAEATTVEDFDEIVEYSDEQRDPPPRPPEGAGLHFQHTHTAFTLRHVLMAMVRSLSQLHPSDMGYYKRSLSTHCRFKKNYATIKDLQDPLDVADKMIEICGQGEALYLTVRNLQSIGRDDLAVILRKTCRRVLLQHDLKIAHDRRYYSLYEGRCRPGQQRYISDVYVEPVTVIRGRRDVVNPENEVRKIPYTIEETAIRPADIFCPLPQDQKPVRTVIMTGVPACGLTVAISKFIIDWMEEKTNRDFQFIFPLPAKDLNFGKDKDRSFLEVISYFYGEAENIKFLEKEDCLCLFIIDSLEMCQHPLDFKNNKTITSAREPAKFDVLLTNLIKGTLLPHCKVWITSHVTDTYRIPSNLVDRYVELRGWTDDKKEEFFTKRTPEPELGRKVYNHMKRSKALEIICHLPLFSWMVAYIYERAFRDPEFGKHPPGITAFYSQYIVVQMNRSFEKYRGCNVDAQKWTDFDKNFTELMGKMAYRMIQEARDYFTVDDLQAVGLKYDDLKCRDGLTTEVKRESADVRTWVFKFVHVTVQEYIAAMYVYVAYRKNGKNVIEPNKMTSWLPGSNKDRSVIDLYRPAIDRALASPNGQWDMFLRFLIGLVTPGTEENLHGYQLNHYHPKAKGTEDVVKYIKKKMKDSLNPDRYKNLELCLVELEEGKEEVRR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048583 (regulation of response to stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048585 (negative regulation of response to stimulus), GO:0032101 (regulation of response to external stimulus), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0031348 (negative regulation of defense response), GO:0032102 (negative regulation of response to external stimulus), GO:0030097 (hemopoiesis), GO:0022008 (neurogenesis), GO:0021782 (glial cell development), GO:0010001 (glial cell differentiation), GO:0007417 (central nervous system development), GO:0050728 (negative regulation of inflammatory response), GO:0007399 (nervous system development), GO:0002521 (leukocyte differentiation), GO:0050727 (regulation of inflammatory response), GO:0030099 (myeloid cell differentiation), GO:0031347 (regulation of defense response), GO:0061515 (myeloid cell development), GO:0002573 (myeloid leukocyte differentiation), GO:0042063 (gliogenesis), GO:0030225 (macrophage differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Cellular tumor antigen p53 (A0A8M3AVI5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
Sequence:
MLCVGDLPHYYSTSQYSLLSSSMDQGLGNRAASTSPYSSETTSNVPTPSPYSQPNSTFEAMSPAPAIPSNTDYPGPHNFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKLASSPPNGSVIRAMPIYKKAEHVTEVVKRCPNHELGRDFNESQTAPASHLIRVEGNNLCQYVDDPVTGRQSVLVPYESPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLETRDGQVLGRRSFEGRICACPGRDRKADEDHFREQQALNESVAKNGNANKRNFKQTPTNITGPSINIKKRRHGEEEMYYIPVRGRENFDILMKIKDSLELVEFVPQQLVDSYRQQQQQLLQRQNHVASPSSYGTLNNMNKIHGPISKLPSVNQLVTQQTQQSAGPSASLSHMGANMLGGHHMQSNGDVNGAHQSQSIVSTSHCTPPPPYNPDPSLVSFLTSLGCQNCIDYFTSQGLQSVYHLQTLTMEDLGALKIPEQFRLAIWRGLQEMKQGHDYGQQLIRSSSNMATMAIGPSGELQRQRVMEAVHFRVRHTITIPNRGPANGPEEWPDFGFDMPDCRLHKHSIKEEFAEGDVH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0005667 (transcription regulator complex)
Protein: Homeobox protein engrailed-like (A0A8M3B3Y5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
Sequence:
MDEQKDQNSRDSTESESVSLSPNIPSPPILPHQAAQQAHRTTNFFIDNILRPDFGCKKDPGSRDRAQTSGRENVNPMVIRPSHNSSLCQDSNCSSDSTSSSSSSSPSSKQSSVKHFEGNGSTAARNGENTPSIMMVNANGGTPPAKESQPLLWPAWVYCTRYSDRPSSVSTLGPRTRKLKKKKSEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQSLAQELNLNESQIKIWFQNKRAKIKKASGYKNGLALQLMAQGLYNHSTTTVQDEKEDSE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0060384 (innervation), GO:0032989 (cellular component morphogenesis), GO:0021675 (nerve development), GO:0000902 (cell morphogenesis), GO:0045165 (cell fate commitment), GO:0060385 (axonogenesis involved in innervation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0048663 (neuron fate commitment), GO:0032990 (cell part morphogenesis), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Cleavage and polyadenylation specificity factor subunit 4 (A0A8M9PJH3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U)
Subcellular location: Nucleus
InterPro domains:
- IPR036875: Zinc finger, CCHC-type superfamily (homologous_superfamily) [225-261]
- IPR036855: Zinc finger, CCCH-type superfamily (homologous_superfamily) [63-171]
- IPR001878: Zinc finger, CCHC-type (domain) [245-261]
- IPR045348: CPSF complex subunit CPSF4-like (family) [1-263]
- IPR041686: Zinc-finger CCCH domain (domain) [40-118]
- IPR000571: Zinc finger, CCCH-type (domain) [35-169]
Sequence:
MQELIATVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEYFMRAACMKGGMCPFRHISGEKTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYDRGFCKHGPDCRHRHTRRVICVNYLVGFCPEGKSCKFMHPRFELPMGATEQPPLPQQVQTQQKQNMQPMNRSSQSLIQLTNPNISNNNHQRIPNAVGIVHSNSHMGGARGPRPLDQVTCYKCGEKGHYANKCTKGHLAFLSGQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0090596 (sensory organ morphogenesis), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0048880 (sensory system development), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0007423 (sensory organ development), GO:0042461 (photoreceptor cell development), GO:0046530 (photoreceptor cell differentiation), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0048699 (generation of neurons), GO:0001754 (eye photoreceptor cell differentiation), GO:0042462 (eye photoreceptor cell development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)