Protein: Tyrosine-protein kinase receptor (A0A8J8YUT9)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR008266: Tyrosine-protein kinase, active site (active_site) [660-672]
- IPR000719: Protein kinase domain (domain) [526-795]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [148-195]
- IPR031635: Growth factor receptor NTRK, leucine rich repeat C-terminal (domain) [151-195]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [505-793]
- IPR000372: Leucine-rich repeat N-terminal domain (domain) [31-65]
- IPR013098: Immunoglobulin I-set (domain) [204-374]
- IPR003598: Immunoglobulin subtype 2 (domain) [209-273]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [203-383]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [526-795]
- IPR020777: Growth factor receptor NTRK (family) [86-361]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [527-794]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [196-385]
- IPR001611: Leucine-rich repeat (repeat) [92-149]
- IPR020455: BDNF/NT-3 growth factors receptor NTRK2 (family) [16-343]
- IPR003599: Immunoglobulin domain subtype (domain) [203-284]
- IPR002011: Tyrosine-protein kinase, receptor class II, conserved site (conserved_site) [688-696]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [32-185]
- IPR007110: Immunoglobulin-like domain (domain) [197-282]
- IPR017441: Protein kinase, ATP binding site (binding_site) [532-560]
Sequence:
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0038023 (signaling receptor activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0019838 (growth factor binding), GO:0004888 (transmembrane signaling receptor activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0019899 (enzyme binding), GO:0016301 (kinase activity), GO:0019199 (transmembrane receptor protein kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004713 (protein tyrosine kinase activity), GO:0002020 (protease binding), GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0009892 (negative regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0034248 (regulation of amide metabolic process), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0034249 (negative regulation of amide metabolic process), GO:1902991 (regulation of amyloid precursor protein catabolic process), GO:0019220 (regulation of phosphate metabolic process), GO:0031399 (regulation of protein modification process), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:1902992 (negative regulation of amyloid precursor protein catabolic process), GO:1902003 (regulation of amyloid-beta formation), GO:0045937 (positive regulation of phosphate metabolic process), GO:1902430 (negative regulation of amyloid-beta formation), GO:0031401 (positive regulation of protein modification process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0042327 (positive regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)