Protein: RCG37592 (A6K7W0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus, trans-Golgi network
InterPro domains:
- IPR048491: XMAP215/Dis1/CLASP, TOG domain (domain) [25-201]
- IPR021133: HEAT, type 2 (repeat) [168-206]
- IPR011989: Armadillo-like helical (homologous_superfamily) [2-1504]
- IPR034085: TOG domain (domain) [1-1501]
- IPR016024: Armadillo-type fold (homologous_superfamily) [1-1488]
- IPR024395: CLASP N-terminal domain (domain) [320-537]
- IPR057546: Stalled ribosome sensor GCN1-like, HEAT repeats region (domain) [1278-1404]
Sequence:
MEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVNSSNYKVVLLGMDILSALVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMDQAANPQYVWDRMLGGFKHKNFRTREGICLCLIATLNASGAQTLTLSKIVPHICNLLGDPNSQVRDAAINSLVEIYRHVGERVRADLSKKGLPQSRLNVIFTKFDEVQKSGNMIQSANDKNFDDEDSVDGNRPSSASSSSSKAPSSSRRNVSMGTTRRLMASSLGSKSSAAKEGAGAVDEEDFIKAFDDVPVVQIYSSRDLEESINKIREILSDDKHDWEQRVNALKKIRSLLLAGAAEYDNFFQHLRLLDGAFKLSAKDLRSQVVREACITLGHLSSVLGNKFDHGAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTHIPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQEWQTHSLERHISVLAETIKKGIHDADSEARIEARKCYWGFHSHFSREAEHLYHTLESSYQKALQSHLKNSDSIVSLPQSDRSSSSSQESLNRPLSAKRSPTGSTASRGSTVSTKSMSTTGSLQRSRSDIDVNAAASAKSKVSSSSGSTAFSSAAALPPGSYASLDVMETLFLLYPPGRIRTRRQSSGSTTNVASTSSDSRGRSRAKVVSQSQPGSRSSSPGKLLGSGYGGLAGGSSRGPPVTPSSEKRSKIPRSQGCSRETSPNRIGLARSSRIPRPSMSQGCSRDTSRESSRDTSPARGFTPLDRFGLGQSGRIPGSVSAMRVLSTSTDLEAAVADALLLGDARSKKKPVRRRYEPYGMYSDDDANSDASSVCSERSYGSRNGGIPHYLRQTEDVAEVLNHCASSNWSERKEGLLGLQNLLKSQRTLSRVELKRLCEIFTRMFADPHSKVFSMFLETLVDFIIIHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRDSFPFDQQFNILMRFIVDQTQTPNLKVKVAILKYIESLARQMDPTDFVNSSETRLAVSRIITWTTEPKSSDVRKAAQIVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLKNSSNAGVGSPSNTIGRTPSRHPSSRTSPLTSPTNCSHGGLSPRLSGALTLPENLNSEEIYSSLRGVTEAIEKFSFRSQEDLNEPIKRDGKKDCDIVSRDGGAASPATEGRGGSEVEGGRMALDNKTSLLNTQPPRAFPGPRAREYNPYPYSDTINTYDKTALKEAVFDDDMEQLRDVPIDHSDLVADLLKELSNHNERVEERKGALLELLKITREDSLGVWEEHFKTILLLLLETLGDKDHSIRALALRVLREILRNQPARFKNYAELTIMKTLEAHKDSHKEVVRAAEEAASTLASSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVERITKESLLQLLVDIIPGLLQGYDNTESSVRKASVFCLVAIYSVIGEDLKPHLAQLTGSKMKLLNLYIKRAQTTNSNSSSSSDVSTHS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding), GO:0051010 (microtubule plus-end binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048870 (cell motility), GO:0007163 (establishment or maintenance of cell polarity), GO:0048522 (positive regulation of cellular process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0048523 (negative regulation of cellular process), GO:0051050 (positive regulation of transport), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0051129 (negative regulation of cellular component organization), GO:0030010 (establishment of cell polarity), GO:0032388 (positive regulation of intracellular transport), GO:0060341 (regulation of cellular localization), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0051222 (positive regulation of protein transport), GO:0032886 (regulation of microtubule-based process), GO:0051128 (regulation of cellular component organization), GO:0016477 (cell migration), GO:0031109 (microtubule polymerization or depolymerization), GO:1902903 (regulation of supramolecular fiber organization), GO:0010639 (negative regulation of organelle organization), GO:0043242 (negative regulation of protein-containing complex disassembly), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:1904951 (positive regulation of establishment of protein localization), GO:0043244 (regulation of protein-containing complex disassembly), GO:0033043 (regulation of organelle organization), GO:0032880 (regulation of protein localization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0022411 (cellular component disassembly), GO:0097435 (supramolecular fiber organization), GO:0001667 (ameboidal-type cell migration), GO:0010761 (fibroblast migration), GO:0007010 (cytoskeleton organization), GO:0007026 (negative regulation of microtubule depolymerization), GO:0051493 (regulation of cytoskeleton organization), GO:0051494 (negative regulation of cytoskeleton organization), GO:1901879 (regulation of protein depolymerization), GO:0031110 (regulation of microtubule polymerization or depolymerization), GO:0032984 (protein-containing complex disassembly), GO:0031114 (regulation of microtubule depolymerization), GO:0007019 (microtubule depolymerization), GO:1901880 (negative regulation of protein depolymerization), GO:0031111 (negative regulation of microtubule polymerization or depolymerization), GO:0051261 (protein depolymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0099080 (supramolecular complex), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0000775 (chromosome, centromeric region), GO:0000776 (kinetochore), GO:0043228 (non-membrane-bounded organelle), GO:0000779 (condensed chromosome, centromeric region), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0000793 (condensed chromosome)