Protein: DNA repair protein RAD51 homolog (A6HPE0)
Organism: Rattus norvegicus (Rat)
Function: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair
Subcellular location: Chromosome. Nucleus
InterPro domains:
- IPR011941: DNA recombination/repair protein Rad51 (family) [25-339]
- IPR003593: AAA+ ATPase domain (domain) [119-306]
- IPR010995: DNA repair Rad51/transcription factor NusA, alpha-helical (homologous_superfamily) [17-85]
- IPR020588: DNA recombination and repair protein RecA-like, ATP-binding domain (domain) [98-269]
- IPR020587: DNA recombination and repair protein RecA, monomer-monomer interface (domain) [276-339]
- IPR016467: DNA recombination and repair protein, RecA-like (family) [19-338]
- IPR013632: Rad51-like, C-terminal (domain) [95-337]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [97-339]
Sequence:
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGYHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARGFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0008094 (ATP-dependent activity, acting on DNA), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0097367 (carbohydrate derivative binding), GO:0003676 (nucleic acid binding), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0042802 (identical protein binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0140097 (catalytic activity, acting on DNA), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0003677 (DNA binding), GO:0032555 (purine ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0005524 (ATP binding), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0022414 (reproductive process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0009628 (response to abiotic stimulus), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:1903046 (meiotic cell cycle process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0061982 (meiosis I cell cycle process), GO:1901360 (organic cyclic compound metabolic process), GO:0140013 (meiotic nuclear division), GO:0104004 (cellular response to environmental stimulus), GO:0006139 (nucleobase-containing compound metabolic process), GO:0009410 (response to xenobiotic stimulus), GO:0009314 (response to radiation), GO:0070887 (cellular response to chemical stimulus), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0009636 (response to toxic substance), GO:0016043 (cellular component organization), GO:1901700 (response to oxygen-containing compound), GO:0072718 (response to cisplatin), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0071478 (cellular response to radiation), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006259 (DNA metabolic process), GO:0014070 (response to organic cyclic compound), GO:0006996 (organelle organization), GO:0007127 (meiosis I), GO:0010212 (response to ionizing radiation), GO:0071479 (cellular response to ionizing radiation), GO:0010165 (response to X-ray), GO:0048285 (organelle fission), GO:0006310 (DNA recombination), GO:0006281 (DNA repair), GO:0010332 (response to gamma radiation), GO:0000280 (nuclear division), GO:0000725 (recombinational repair), GO:0071480 (cellular response to gamma radiation), GO:0006302 (double-strand break repair), GO:0000724 (double-strand break repair via homologous recombination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)