Protein: 7-beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase (P32370)
Organism: Clostridium scindens (strain JCM 10418 / VPI 12708)
Function: NADH-dependent flavin oxidoreductase. Stereo-specific NAD(H)-dependent 3- oxo-delta4-cholenoic acid oxidoreductase involved in bile acid 7beta- dehydroxylation
InterPro domains:
- IPR023753: FAD/NAD(P)-binding domain (domain) [384-625]
- IPR051793: NADH:flavin oxidoreductase/NADH oxidase (family) [3-660]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [360-655]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [1-381]
- IPR001155: NADH:flavin oxidoreductase/NADH oxidase, N-terminal (domain) [8-337]
Sequence:
MDMKHSRLFSPLQIGSLTLSNRVGMAPMSMDYEAADGTVPKRLADVFVRRAEGGTGYVMIDAVTIDSKYPYMGNTTALDRDELVPQFKEFADRVKEAGSTLVPQIIHPGPESVCGYRHIAPLGPSANTNANCHVSRSISIDEIHDIIKQFGQAARRAEEAGCGAISLHCAHAYMLPGSFLSPLRNKRMDEYGGSLDNRARFVIEMIEEARRNVSPDFPIFLRISGDERMVGGNSLEDMLYLAPKFEAAGVSMLEVSGGTQYEGLEHIIPCQNKSRGVNVYEASEIKKVVGIPVYAVGKINDIRYAAEIVERGLVDGVAMGRPLLADPDLCKKAVEGQFDEITPCASCGGSCISRSEAAPECHCHINPRLGREYEFPDVPAEKSKKVLVIGAGPGGMMAAVTAAERGHDVTVWEADDKIGGQLNLAVVAPGKQEMTQWMVHLNYRAKKAGVKFEFNKEATAEDVKALAPEAVIVATGAKPLVPPIKGTQDYPVLTAHDFLRGKFVIPKGRVCVLGGGAVACETAETALENARPNSYTRGYDASIGDIDVTLVEMLPQLLTGVCAPNREPLIRKLKSKGVHINVNTKIMEVTDHEVKVQRQDGTQEWLEGFDYVLFGLGSRNYDPLSETLKEFVPEVHVIGDAVRARQASYAMWEGFEKAYSL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0016628 (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0044248 (cellular catabolic process), GO:0006082 (organic acid metabolic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0016054 (organic acid catabolic process), GO:0009072 (aromatic amino acid metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:0019439 (aromatic compound catabolic process), GO:0009063 (amino acid catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:1901606 (alpha-amino acid catabolic process), GO:0009074 (aromatic amino acid family catabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0006558 (L-phenylalanine metabolic process), GO:1902222 (erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process), GO:1902221 (erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process), GO:0006559 (L-phenylalanine catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)