Protein: ATP-dependent RNA helicase DDX1 (A0A7I2YQ77)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytosol. Cytoplasmic granule. Mitochondrion
InterPro domains:
- IPR001650: Helicase, C-terminal domain-like (domain) [496-562]
- IPR043136: B30.2/SPRY domain superfamily (homologous_superfamily) [90-259]
- IPR003877: SPRY domain (domain) [130-246]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [58-250]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-574]
- IPR011545: DEAD/DEAH-box helicase domain (domain) [26-413]
- IPR014014: RNA helicase, DEAD-box type, Q motif (domain) [2-30]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [21-444]
- IPR001870: B30.2/SPRY domain (domain) [70-247]
Sequence:
MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPVIQIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRATKGLMKGKHYYEVSCHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVKFSKNGKDLGLAFEIPPHMKNQALFPACVLKNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGSYKGHVDILAPTVQELAALEKEAQTSFLHLGYLPNQLFRTF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140110 (transcription regulator activity), GO:0140657 (ATP-dependent activity), GO:0004386 (helicase activity), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0008094 (ATP-dependent activity, acting on DNA), GO:0016787 (hydrolase activity), GO:0003682 (chromatin binding), GO:0097159 (organic cyclic compound binding), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0008186 (ATP-dependent activity, acting on RNA), GO:0003712 (transcription coregulator activity), GO:0003676 (nucleic acid binding), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0140097 (catalytic activity, acting on DNA), GO:0003724 (RNA helicase activity), GO:0004518 (nuclease activity), GO:0003723 (RNA binding), GO:0003727 (single-stranded RNA binding), GO:0070717 (poly-purine tract binding), GO:0008143 (poly(A) binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0044238 (primary metabolic process), GO:0046483 (heterocycle metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0051236 (establishment of RNA localization), GO:0043170 (macromolecule metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0046907 (intracellular transport), GO:0006139 (nucleobase-containing compound metabolic process), GO:0006403 (RNA localization), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0050658 (RNA transport), GO:0071705 (nitrogen compound transport), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0010468 (regulation of gene expression), GO:0090304 (nucleic acid metabolic process), GO:0008104 (protein localization), GO:0010467 (gene expression), GO:0010629 (negative regulation of gene expression), GO:0006913 (nucleocytoplasmic transport), GO:0016070 (RNA metabolic process), GO:0031047 (RNA-mediated gene silencing), GO:0006406 (mRNA export from nucleus), GO:0006405 (RNA export from nucleus), GO:0006396 (RNA processing), GO:0015931 (nucleobase-containing compound transport), GO:0034470 (ncRNA processing), GO:0070918 (regulatory ncRNA processing), GO:0050657 (nucleic acid transport), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0051168 (nuclear export), GO:0034660 (ncRNA metabolic process), GO:0035196 (miRNA processing), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0031053 (primary miRNA processing), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)