Protein: Gap junction protein (A6KHB2)
Organism: Rattus norvegicus (Rat)
Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell
Subcellular location: Cell junction, gap junction. Cell membrane; Multi- pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR000500: Connexin (family) [1-257]
- IPR038359: Connexin, N-terminal domain superfamily (homologous_superfamily) [1-226]
- IPR013092: Connexin, N-terminal (domain) [2-214]
- IPR019570: Connexin, cysteine-rich domain (domain) [146-213]
- IPR017990: Connexin, conserved site (conserved_site) [53-185]
Sequence:
MDWGTLHTVIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCKNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETARKFIRGEKRNEFKDLEDIKRQKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDCFISRPTEKTVFTVFMISASVICMLLNVAELCYLLLKLCFRRSKRTQAQRNHPNHALKESKQNEMNELISDSGQNAITSFPS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0044877 (protein-containing complex binding), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0051015 (actin filament binding), GO:0022803 (passive transmembrane transporter activity), GO:0008092 (cytoskeletal protein binding), GO:0015267 (channel activity), GO:0003779 (actin binding), GO:0015631 (tubulin binding), GO:0048487 (beta-tubulin binding), GO:0008017 (microtubule binding), GO:0022829 (wide pore channel activity), GO:0005243 (gap junction channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048878 (chemical homeostasis), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0019725 (cellular homeostasis), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007568 (aging), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0051602 (response to electrical stimulus), GO:0055082 (intracellular chemical homeostasis), GO:0012501 (programmed cell death), GO:0042127 (regulation of cell population proliferation), GO:0043207 (response to external biotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0008285 (negative regulation of cell population proliferation), GO:0009617 (response to bacterium), GO:0048513 (animal organ development), GO:0033500 (carbohydrate homeostasis), GO:1901700 (response to oxygen-containing compound), GO:0048839 (inner ear development), GO:0010033 (response to organic substance), GO:0009743 (response to carbohydrate), GO:0032496 (response to lipopolysaccharide), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0042593 (glucose homeostasis), GO:0007423 (sensory organ development), GO:0006915 (apoptotic process), GO:0002237 (response to molecule of bacterial origin), GO:0001678 (intracellular glucose homeostasis), GO:1901701 (cellular response to oxygen-containing compound), GO:0071322 (cellular response to carbohydrate stimulus), GO:0071333 (cellular response to glucose stimulus), GO:0043583 (ear development), GO:0034284 (response to monosaccharide), GO:0009746 (response to hexose), GO:0071326 (cellular response to monosaccharide stimulus), GO:0071331 (cellular response to hexose stimulus), GO:0009749 (response to glucose)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0045177 (apical part of cell), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0005911 (cell-cell junction), GO:0005921 (gap junction)