Protein: Calcium-transporting ATPase (A0A8M9Q0B2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the hydrolysis of ATP coupled with the transport of calcium
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi- pass membrane protein
InterPro domains:
- IPR006408: P-type ATPase, subfamily IIB (family) [357-1063]
- IPR023214: HAD superfamily (homologous_superfamily) [685-811]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [475-481]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [479-690]
- IPR006068: Cation-transporting P-type ATPase, C-terminal (domain) [880-1058]
- IPR022141: Plasma membrane calcium transporting P-type ATPase, C-terminal (domain) [1105-1182]
- IPR044492: P-type ATPase, haloacid dehalogenase domain (domain) [455-847]
- IPR059000: P-type ATPase, A domain (domain) [187-285]
- IPR001757: P-type ATPase (family) [154-876]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [45-1064]
- IPR004014: Cation-transporting P-type ATPase, N-terminal (domain) [45-121]
- IPR036412: HAD-like superfamily (homologous_superfamily) [472-899]
- IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [187-285]
Sequence:
MANNSYSGVKNSVAEPNHNGEFGCSLKELRSLMELRGAEGLQKIQETYGDVNGLCNRLKTSAVDGLSGQPSDIEKRKAAFGQNFIPPKKPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYKPPDAGDKNCVKGTGGEPEEEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFSVVRGGQVIQIHVAEIVVGDIAQIKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDAMLLSGTHVMEGSGKIVVTAVGVNSQTGIIFTLLGAGEDDDDEEEKEKKKEKERKKEKKNKKQDGSVENRKKAKAQDGAAMEMQPLNSDEGADGEEKRKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVVLFVVDTFWVDKIPWDSGCIPIYIQFFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQVFIADKHYRKVPEPDVVPASTMDLLIVGISVNCAYTTKIMSPEKEGGLNRQVGNKTECALLGFALDLKKDYQAVRNEIPEEKLYKVYTFNSVRKSMSTVLKNDDGSYRMFSKGASEILLKKCFKILTSTGEAKVFRPRDRDDMVKRVIEPMASEGLRTICLAYRDFPASEGEPDWDNEADILTRLTCVCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNLNTARAIATKCGILQVGDDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVVEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAVYQLIIIFTLLFAGEKMFNIDSGRYADLHAPPSEHYTIVFNTFVMMQLFNEINARKIHGERNVFEGIFNNMIFCTIVFGTFVIQIVIVQFGGKPFSCVGLNIEQWLWCIFLGFGCLLWGQVISTIPTSRLTFLKTAGHGTQKEEIPDEELEELEDLDEIDHAERELRRGQILWFRGLNRIQTQMDVVSAFQSGISFQAAVRRQPSSGSQQHDIRVVNAFRSSLSPYEGLEKPESRTSIHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNATPTPPPPPSPNQNNNAVDSGVHLFLDPSKSATPSAPGSPMHSLETSL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0140358 (P-type transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015662 (P-type ion transporter activity), GO:0005388 (P-type calcium transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0001503 (ossification), GO:0003008 (system process), GO:0048840 (otolith development), GO:0009887 (animal organ morphogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0050877 (nervous system process), GO:0030282 (bone mineralization), GO:0048839 (inner ear development), GO:0022008 (neurogenesis), GO:0048882 (lateral line development), GO:0048705 (skeletal system morphogenesis), GO:0060348 (bone development), GO:0007399 (nervous system development), GO:0001501 (skeletal system development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0042476 (odontogenesis), GO:0031214 (biomineral tissue development), GO:0060349 (bone morphogenesis), GO:0060113 (inner ear receptor cell differentiation), GO:0030182 (neuron differentiation), GO:0007600 (sensory perception), GO:0048666 (neuron development), GO:0042490 (mechanoreceptor differentiation), GO:0048925 (lateral line system development), GO:0060119 (inner ear receptor cell development), GO:0034505 (tooth mineralization), GO:0048699 (generation of neurons), GO:0043583 (ear development), GO:0048884 (neuromast development), GO:0050954 (sensory perception of mechanical stimulus), GO:0048916 (posterior lateral line development), GO:0007605 (sensory perception of sound), GO:0048881 (mechanosensory lateral line system development), GO:0048919 (posterior lateral line neuromast development), GO:0048915 (posterior lateral line system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)