Protein: Structural maintenance of chromosomes protein 1A (A0A6Q8PHC3)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome. Nucleus
InterPro domains:
- IPR024704: Structural maintenance of chromosomes protein (family) [15-954]
- IPR003395: RecF/RecN/SMC, N-terminal (domain) [15-952]
- IPR028468: Smc1, ATP-binding cassette domain (domain) [861-964]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [14-969]
- IPR010935: SMCs flexible hinge (domain) [257-373]
- IPR036277: SMCs flexible hinge superfamily (homologous_superfamily) [218-422]
Sequence:
MLEVSIPTPHRYVRGKSNLMDAISFVLGEKTSNLRVKTLRDLIHGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVYPEQGDCVISKVLTFDLTKYPDANPNPNEQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0046983 (protein dimerization activity), GO:0003723 (RNA binding), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007017 (microtubule-based process), GO:0044238 (primary metabolic process), GO:0044085 (cellular component biogenesis), GO:1903047 (mitotic cell cycle process), GO:0009314 (response to radiation), GO:0046483 (heterocycle metabolic process), GO:0007051 (spindle organization), GO:0071495 (cellular response to endogenous stimulus), GO:0007062 (sister chromatid cohesion), GO:0000226 (microtubule cytoskeleton organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0071216 (cellular response to biotic stimulus), GO:0007059 (chromosome segregation), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0033554 (cellular response to stress), GO:0016043 (cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0000278 (mitotic cell cycle), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0098813 (nuclear chromosome segregation), GO:0072396 (response to cell cycle checkpoint signaling), GO:0006974 (cellular response to DNA damage stimulus), GO:0140014 (mitotic nuclear division), GO:0007052 (mitotic spindle organization), GO:0022607 (cellular component assembly), GO:0051225 (spindle assembly), GO:0090304 (nucleic acid metabolic process), GO:0006259 (DNA metabolic process), GO:0007064 (mitotic sister chromatid cohesion), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0070925 (organelle assembly), GO:0048285 (organelle fission), GO:0006281 (DNA repair), GO:0051276 (chromosome organization), GO:0007010 (cytoskeleton organization), GO:0000819 (sister chromatid segregation), GO:0090307 (mitotic spindle assembly), GO:0000280 (nuclear division), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)