Protein: receptor protein-tyrosine kinase (A6JRG8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single- pass type I membrane protein
InterPro domains:
- IPR003961: Fibronectin type III (domain) [444-733]
- IPR050122: Receptor Tyrosine Kinase (family) [152-1094]
- IPR002049: Laminin-type EGF domain (domain) [230-275]
- IPR000742: EGF-like domain (domain) [219-299]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [820-1087]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [956-968]
- IPR000719: Protein kinase domain (domain) [820-1092]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [23-732]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [445-734]
- IPR018941: Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal (domain) [24-118]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [370-450]
- IPR007110: Immunoglobulin-like domain (domain) [350-440]
- IPR017441: Protein kinase, ATP binding site (binding_site) [826-851]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [820-1088]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [815-1103]
Sequence:
MDSLAGLVLCGVSLLLYGLVEGAMDLILINSLPLVSDAETSLTCIASGWHPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGQAIRIRTMKMRQQASFLPATLTMTVDRGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPDCNRPCTTCKNNGVCHEDTGECICPPGFMGRTCEKACEPHTFGRTCKERCSGSEGCKSYVFCLPDPYGCSCATGWRGLQCNEACPYGHYGPDCKLRCHCTNEEMCDRFQGCLCSQGWQGLQCEKEGRPRMTPQIEDLPDHIEVNSGKFNPICKASGWPLPTSEEMTLVKPDGTVLQPNDFNHTDHFSVAIFTVNRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPEPLHAPNVIDTGHNFAIINISSEPYFGDGPIKSKKLFYKPVNQAWKYIQVMNEIVTLNYLEPRTDYELCVQLVRPGEGGEGHPGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIFTSSEDEFYVEVERWSQQTRSDQQNIKVPGNLTSVLLNNLLPREQYSVRARVNTKAQGEWSEELRAWTLSDILPPQPENIKITNITDYTALVSWTIVDGYSISSIIIRYKVQGKNEDQHIDVKIKNATITQYQLKGLEPETTYHVDIFAENNIGSSNPAFSQEIRTLPAPKDLGGGKMLLIAILGSAGMTCITVLLAFLIMLQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKAKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019838 (growth factor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0001503 (ossification), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0001666 (response to hypoxia), GO:0001568 (blood vessel development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0070482 (response to oxygen levels), GO:0048513 (animal organ development), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0035295 (tube development), GO:1904018 (positive regulation of vasculature development), GO:0009887 (animal organ morphogenesis), GO:2000026 (regulation of multicellular organismal development), GO:0036075 (replacement ossification), GO:1901698 (response to nitrogen compound), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0007166 (cell surface receptor signaling pathway), GO:0035239 (tube morphogenesis), GO:1901652 (response to peptide), GO:0046683 (response to organophosphorus), GO:0048705 (skeletal system morphogenesis), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0001944 (vasculature development), GO:1901342 (regulation of vasculature development), GO:0045766 (positive regulation of angiogenesis), GO:0043627 (response to estrogen), GO:0043434 (response to peptide hormone), GO:0051591 (response to cAMP), GO:0060348 (bone development), GO:0010243 (response to organonitrogen compound), GO:0048514 (blood vessel morphogenesis), GO:0001501 (skeletal system development), GO:0001958 (endochondral ossification), GO:0072359 (circulatory system development), GO:0036293 (response to decreased oxygen levels), GO:0001570 (vasculogenesis), GO:0060349 (bone morphogenesis), GO:0045765 (regulation of angiogenesis), GO:0014070 (response to organic cyclic compound), GO:0060350 (endochondral bone morphogenesis), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0014074 (response to purine-containing compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0048471 (perinuclear region of cytoplasm), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)