Protein: Aminopeptidase (A6HIJ7)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single- pass type II membrane protein
InterPro domains:
- IPR001930: Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase (family) [91-286]
- IPR034016: Aminopeptidase N-type (family) [1-405]
- IPR014782: Peptidase M1, membrane alanine aminopeptidase (domain) [186-403]
- IPR024571: ERAP1-like C-terminal domain (domain) [484-797]
- IPR050344: Peptidase M1 family aminopeptidases (family) [1-815]
- IPR042097: Aminopeptidase N-like , N-terminal domain superfamliy (homologous_superfamily) [1-159]
- IPR027268: Peptidase M4/M1, CTD superfamily (homologous_superfamily) [160-408]
- IPR045357: Aminopeptidase N-like , N-terminal domain (domain) [1-151]
Sequence:
MNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSRYTTPAGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLESASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKFCASGPYVGEDCPQWMVPITISTSEDPNQAKLKILMDKPEMSVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKEHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLSPELIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDADSIHQYLLQRKASPPSV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008238 (exopeptidase activity), GO:0004177 (aminopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0048522 (positive regulation of cellular process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0051050 (positive regulation of transport), GO:0044238 (primary metabolic process), GO:0001666 (response to hypoxia), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0032388 (positive regulation of intracellular transport), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0060341 (regulation of cellular localization), GO:0070482 (response to oxygen levels), GO:0019538 (protein metabolic process), GO:0051222 (positive regulation of protein transport), GO:0043170 (macromolecule metabolic process), GO:0071456 (cellular response to hypoxia), GO:0036211 (protein modification process), GO:0090316 (positive regulation of intracellular protein transport), GO:0051223 (regulation of protein transport), GO:0043412 (macromolecule modification), GO:0071453 (cellular response to oxygen levels), GO:1904951 (positive regulation of establishment of protein localization), GO:0036293 (response to decreased oxygen levels), GO:0070201 (regulation of establishment of protein localization), GO:0032880 (regulation of protein localization), GO:0032386 (regulation of intracellular transport), GO:0036294 (cellular response to decreased oxygen levels), GO:1903955 (positive regulation of protein targeting to mitochondrion), GO:1903747 (regulation of establishment of protein localization to mitochondrion), GO:0070647 (protein modification by small protein conjugation or removal), GO:0033157 (regulation of intracellular protein transport), GO:1903749 (positive regulation of establishment of protein localization to mitochondrion), GO:0032446 (protein modification by small protein conjugation), GO:1903214 (regulation of protein targeting to mitochondrion), GO:1903533 (regulation of protein targeting), GO:0016567 (protein ubiquitination), GO:0000209 (protein polyubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)