Protein: Signal transducer and activator of transcription (A6INW8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR038295: STAT1, C-terminal domain superfamily (homologous_superfamily) [709-749]
- IPR013799: STAT transcription factor, protein interaction (domain) [2-122]
- IPR012345: STAT transcription factor, DNA-binding, N-terminal (homologous_superfamily) [318-460]
- IPR001217: Transcription factor STAT (family) [1-733]
- IPR013801: STAT transcription factor, DNA-binding (domain) [322-458]
- IPR035859: STAT1, SH2 domain (domain) [557-707]
- IPR000980: SH2 domain (domain) [573-670]
- IPR013800: STAT transcription factor, all-alpha domain (domain) [144-305]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [317-568]
- IPR048988: Signal transducer and activator of transcription, linker domain (domain) [481-558]
- IPR022752: Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal (domain) [715-738]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [569-710]
- IPR015988: STAT transcription factor, coiled coil (homologous_superfamily) [134-317]
- IPR036535: STAT transcription factor, N-terminal domain superfamily (homologous_superfamily) [1-126]
Sequence:
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMIIHNCLKEERKILENAQRFNQAQEGNIQNTVMLDKQKELDSKVRNVKDQVMCIEHEIKTLEDLQDEYDFKCKTSQNRESEANGVAKSDQKQEQLLLHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPNACLDQLQSWFTIVAESLQQVRQQLKKLEELEQKFTYEQDPITKNKQVLSDRTFVLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVSFDKDVNEKNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGNRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVTEPRNLSFFLNPPCAWWSQLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTILELIKKHLLCLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDDPKRTGYIKTELISVSEVHPSRLQSTENLLPMSPEEFDEMSKIVGSEFDSMMSAV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0005102 (signaling receptor binding), GO:0019899 (enzyme binding), GO:0003677 (DNA binding), GO:0005126 (cytokine receptor binding), GO:0019902 (phosphatase binding), GO:0001664 (G protein-coupled receptor binding), GO:0043565 (sequence-specific DNA binding), GO:0042379 (chemokine receptor binding), GO:0019903 (protein phosphatase binding), GO:0051721 (protein phosphatase 2A binding), GO:0048020 (CCR chemokine receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0008283 (cell population proliferation), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0003008 (system process), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0010463 (mesenchymal cell proliferation), GO:0009410 (response to xenobiotic stimulus), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0003013 (circulatory system process), GO:0009725 (response to hormone), GO:0010035 (response to inorganic substance), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:0008284 (positive regulation of cell population proliferation), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0006979 (response to oxidative stress), GO:1901700 (response to oxygen-containing compound), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0009991 (response to extracellular stimulus), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0007584 (response to nutrient), GO:0009888 (tissue development), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0045596 (negative regulation of cell differentiation), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0009612 (response to mechanical stimulus), GO:0090183 (regulation of kidney development), GO:1901652 (response to peptide), GO:0046683 (response to organophosphorus), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0008015 (blood circulation), GO:0061005 (cell differentiation involved in kidney development), GO:0002053 (positive regulation of mesenchymal cell proliferation), GO:0010468 (regulation of gene expression), GO:0048660 (regulation of smooth muscle cell proliferation), GO:0051591 (response to cAMP), GO:0031667 (response to nutrient levels), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0048762 (mesenchymal cell differentiation), GO:1901701 (cellular response to oxygen-containing compound), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0072001 (renal system development), GO:0071417 (cellular response to organonitrogen compound), GO:0034097 (response to cytokine), GO:0071310 (cellular response to organic substance), GO:0097696 (receptor signaling pathway via STAT), GO:0048661 (positive regulation of smooth muscle cell proliferation), GO:1901699 (cellular response to nitrogen compound), GO:0010628 (positive regulation of gene expression), GO:0060485 (mesenchyme development), GO:0010464 (regulation of mesenchymal cell proliferation), GO:0043434 (response to peptide hormone), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0032870 (cellular response to hormone stimulus), GO:0010243 (response to organonitrogen compound), GO:0031326 (regulation of cellular biosynthetic process), GO:0030857 (negative regulation of epithelial cell differentiation), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0014070 (response to organic cyclic compound), GO:0042542 (response to hydrogen peroxide), GO:0051253 (negative regulation of RNA metabolic process), GO:0001822 (kidney development), GO:0000302 (response to reactive oxygen species), GO:0030856 (regulation of epithelial cell differentiation), GO:2001141 (regulation of RNA biosynthetic process), GO:0001656 (metanephros development), GO:0051769 (regulation of nitric-oxide synthase biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0007259 (receptor signaling pathway via JAK-STAT), GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process), GO:2000696 (regulation of epithelial cell differentiation involved in kidney development), GO:0071375 (cellular response to peptide hormone stimulus), GO:0032868 (response to insulin), GO:0006355 (regulation of DNA-templated transcription), GO:1901653 (cellular response to peptide), GO:0014074 (response to purine-containing compound), GO:0032869 (cellular response to insulin stimulus), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0030425 (dendrite), GO:0030424 (axon), GO:0005634 (nucleus)