Protein: Pleiotropic ABC efflux transporter of multiple drugs CDR1 (A0A2H1A768)
Organism: Candida auris (Yeast)
Function: Pleiotropic ABC efflux transporter that confers resistance to numerous chemicals including itraconazole, fluconazole, voriconazole and posaconazole
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR003593: AAA+ ATPase domain (domain) [191-1087]
- IPR034003: ATP-binding cassette transporter, PDR-like subfamily G, domain 2 (domain) [866-1093]
- IPR034001: ATP-binding cassette transporter, PDR-like subfamily G, domain 1 (domain) [179-397]
- IPR029481: Pleiotropic ABC efflux transporter, N-terminal domain (domain) [51-157]
- IPR010929: CDR ABC transporter (domain) [727-817]
- IPR005285: Pleiotropic drug resistance protein PDR/CDR (family) [107-1501]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [167-1102]
- IPR017871: ABC transporter-like, conserved site (conserved_site) [314-328]
- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [507-1400]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [165-1110]
Sequence:
MSEKPFVDAPPPEDGVAHQVSPHDNGSLSEEANSINEYTGFGAHQEGEIRELARTFTNMSHDSGHDLSKTNTSQDLLKYLSHMSEVPGVEPFDPEQISEQLNPDSPNFNAKFWVKNMRKLFDSNPDYYKPSKLGLAYRNLRAYGVAADSDYQPTVSNGLWKMAVDYWHDMRKIDESRCFDILKTMDGYFKPGEVTVVLGRPGSGCSTLLKTIACNTYGFHIGEESQISYDGMTPDEIHKHHRGDVVYSAETDVHFPHLSVGDTLEFAAKLRTPQNRGEVSRLEHAKHMASVTMATYGLSHTRNTPVGNDFVRGVSGGERKRVSIAEVSLSGANIQCWDNATRGLDAATALEFIRALKTSAAILDATPLIAIYQCSQDAYDLFDNVIVLYEGYQIFFGKASEAKQFFLDMGYECPQRQTTADFLTSLTNPEERVVKPGFENKVPRTAKEFSDYWRNSSNYKVLTAGIDKYLAEVADGSQREAYRASHVAKQSDHTRPSSPYTVSFFMQTRYIIGRNFLRMKGDPSIVIFSIFGQGVMGLILSSVFYNLQPTTGSFYYRGAAMFFAVLFNAFASLLEIMSLFEARPIVEKHKKYALYRPSADALASIISELPVKLCMSTCFNFSFYFMVHFRRDPGRFFFYWLFCGLCTLCMSHMFRSLGAVSTSLAAAMTPATSVLLAMVIFTGFVIPIPSMLGWCRWIQYINPVSYVFESLMVNEFHGRKFECAQFVPSGGPYDQVAAVNRVCSTAGARPGEDFVDGTAYLQTSFEYVNAHKWRNLGIVVAYIVVFLGVYIALTEFNKGAMQKGEIALFLRGSLKKVRKQREQNEAKVNDVENNLPNEKISYSDAMEKDSGESSTSDDKLPNQRQIFHWKDLTYQVKIKAENRVILNHVDGWVKPGQITALMGASGAGKTTLLNCLSERLTTGTVTDGVRMVNGHGLDSSFQRSIGYVQQQDIHLATSTVREALTFSAYLRQPSHVSKKEKDEYVDYVIDLLEMGAYSDALVGVAGEGLNVEQRKRLTIGVELVAKPKLLLFLDEPTSGLDSQTAWSICKLMRKLANHGQAILCTIHQPSAILLQEFDRLLFLQKGGKTVYFGDLGKNCQGLIDYFEKHGAHPCPPDANPAEWMLEVVGAAPGSKAAQDYFEVWRNSEEYQEVQRELAYMENELGKLPVDEDPESRKKYATSLIKQYFIVTWRTFQQYWRSPGYIYSKFFLVITASLFNGFAFFHSGTSQQGLQNQMFSMFMFYMPLQTLIQQMLPYYVMQREIYEVREAPSRTFSWFAFIASQITTEIPFQVVLGTVAFFCWYYPVGLYQNATPTDTVHERGALMWLLVTAFYVYTISLGQMVVAFMEIADNAANMVNLMFIMCLNFCGVLATPEALPGFWIFMYRCNPFTYLIQAMLSTGLANTKIVCSSREILHFQPPSGQTCGQYMQQFISAAGGYLLDESATDQCDFCAMSQTNTFLDSVHAVYSERWRNFGIFIAFIAINMIGTIFFYWLARVPKSSKSKNH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0140359 (ABC-type transporter activity), GO:1901474 (azole transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0098754 (detoxification), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051179 (localization), GO:0140352 (export from cell), GO:0051234 (establishment of localization), GO:1990961 (xenobiotic detoxification by transmembrane export across the plasma membrane), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0140115 (export across plasma membrane), GO:0006810 (transport), GO:0046618 (xenobiotic export from cell), GO:0009636 (response to toxic substance), GO:0042908 (xenobiotic transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)