Protein: Serine/threonine-protein kinase (A6J290)
Organism: Rattus norvegicus (Rat)
Function: Serine/threonine-protein kinase involved in autophagy in response to starvation
InterPro domains:
- IPR045269: Serine/threonine-protein kinase Atg1-like (family) [9-988]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [134-146]
- IPR048941: ATG1-like, MIT domain 2 (domain) [973-1045]
- IPR000719: Protein kinase domain (domain) [16-278]
- IPR022708: Serine/threonine-protein kinase Atg1-like, tMIT domain (domain) [876-961]
- IPR017441: Protein kinase, ATP binding site (binding_site) [22-46]
- IPR016237: Serine/threonine-protein kinase, Ulk1/Ulk2 (family) [1-1051]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [16-323]
Sequence:
MEPGRGGVETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQQIAGAMQLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASTPIKKSPPVPVPSYPSSGSGSSSSSSSASHLASPPSLGEMPQLQKTLTSPADAAGFLQGSRDSGGSSKDSCDTDDFVMVPAQFPGDLVPEAASAKPPPDSLLCSGSSLVASAGLESHGRTPSPSPTCSSSPSPSGRPGPFSSNRYGASVPIPVPTQVHNYQRIEQNLQSPTQQQTARSSAIRRSGSTSPLGFGRASPSPPSHTDGAMLARKLSLGGGRPYTPSPQVGTIPERPSWSRVPSPQGADVRAGRSPRPGSSVPEHSPRTTGLGCRLHSAPNLSDFHVVRPKLPKPPTDPLGATFSPPQTSAPQPCPGLQSCRPLRGSPKLPDFLQRSPLPPILGSPTKAGPSFDFPKAPSSQSLLTLLARQGVVMTPPRNRTLPDLSEAGPFQGQQLGSGLRPAEDTRGPFGRSFSTSRLTDLLLKAAFGTQASDSGSTDSLQEKPMEIAPSAGFGGTLHPGARAGGASSPAPVVFTVGSPPSGTTPPQSTRTRMFSVGSSSSLGSTGSSSARHLVPGACAEAPELSAPGYCCSLADPLAANLEGAVTFEAPDLPEETLMEQEHTETLHSLRFTLAFAQQVLEIAALKGSASEAAGGPEYQLQESVVADQISQLSREWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRFFLDKQRLLDGIHGVTAERLILSHAVQMVQSAALDEMFQHRESCVPRYHKALLLLEGLQHTLTDQADIENIAKCKLCIERRLSALLSGVYA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0044877 (protein-containing complex binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0019899 (enzyme binding), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0048522 (positive regulation of cellular process), GO:0009894 (regulation of catabolic process), GO:0048468 (cell development), GO:0031325 (positive regulation of cellular metabolic process), GO:0030154 (cell differentiation), GO:0033554 (cellular response to stress), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0044089 (positive regulation of cellular component biogenesis), GO:0031099 (regeneration), GO:0009896 (positive regulation of catabolic process), GO:0044087 (regulation of cellular component biogenesis), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0010508 (positive regulation of autophagy), GO:1902117 (positive regulation of organelle assembly), GO:0010506 (regulation of autophagy), GO:0033043 (regulation of organelle organization), GO:0031331 (positive regulation of cellular catabolic process), GO:0031102 (neuron projection regeneration), GO:0031329 (regulation of cellular catabolic process), GO:0010638 (positive regulation of organelle organization), GO:1902115 (regulation of organelle assembly), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:2000786 (positive regulation of autophagosome assembly), GO:0031175 (neuron projection development), GO:0016241 (regulation of macroautophagy), GO:0044090 (positive regulation of vacuole organization), GO:0048699 (generation of neurons), GO:0044088 (regulation of vacuole organization), GO:2000785 (regulation of autophagosome assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0016239 (positive regulation of macroautophagy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0030424 (axon)