lokahq/bioreason-rl huggingface dataset:
Protein: Histone H2A (A6KLI8)
Organism: Rattus norvegicus (Rat)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Subcellular location: Chromosome. Nucleus
InterPro domains:
- IPR007125: Core Histone H2A/H2B/H3 domain (domain) [10-89]
- IPR032458: Histone H2A conserved site (conserved_site) [22-28]
- IPR009072: Histone-fold (homologous_superfamily) [2-130]
- IPR002119: Histone H2A (family) [3-123]
- IPR032454: Histone H2A, C-terminal domain (domain) [92-126]
Sequence:
MSGRAKQGGKARAKAKSRSFRAGLQFPVGRVHRLLRQGNYAERIGAGTPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKSQTK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009314 (response to radiation), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0009416 (response to light stimulus), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006281 (DNA repair), GO:0009411 (response to UV), GO:0009650 (UV protection)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Caspase 7, isoform CRA_c (Q6IRF9)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR001309: Peptidase C14, p20 domain (domain) [66-190]
- IPR016129: Peptidase family C14A, His active site (active_site) [131-145]
- IPR002138: Peptidase C14, caspase non-catalytic subunit p10 (domain) [209-303]
- IPR002398: Peptidase C14 family (family) [19-301]
- IPR029030: Caspase-like domain superfamily (homologous_superfamily) [58-301]
- IPR011600: Peptidase C14, caspase domain (domain) [68-300]
- IPR033139: Peptidase family C14A, cysteine active site (active_site) [177-188]
- IPR015917: Peptidase C14A, caspase catalytic domain (domain) [59-303]
Sequence:
MTDDQDCAAELEMADSSTEDGVDAKPDRSTIISSLLWKKKKNASMCPVSTTRDRVPTYLYRMDFEKMGKCIIINNKNFDKATGMDVRNGTDKDAEALFKCFRSLGFEVTVYNDCSCAKMQDLLRRASEEDHSNSACFACVLLSHGEENLIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRNPGKGSWFVQALCSILNEHGKDLEIMQILTRVNDRVARHFESQSDDPRFNEKKQIPCMVSMLTKELYFGR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0007568 (aging), GO:0009056 (catabolic process), GO:0008219 (cell death), GO:0006807 (nitrogen compound metabolic process), GO:0061061 (muscle structure development), GO:0012501 (programmed cell death), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0030154 (cell differentiation), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0042692 (muscle cell differentiation), GO:0030163 (protein catabolic process), GO:0006915 (apoptotic process), GO:0071887 (leukocyte apoptotic process), GO:0051146 (striated muscle cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Retinoic acid receptor beta (A6K045)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus
InterPro domains:
- IPR000536: Nuclear hormone receptor, ligand-binding domain (domain) [176-410]
- IPR047159: Retinoic acid receptor, DNA-binding domain (domain) [75-159]
- IPR013088: Zinc finger, NHR/GATA-type (homologous_superfamily) [76-175]
- IPR003078: Retinoic acid receptor (family) [53-414]
- IPR035500: Nuclear hormone receptor-like domain superfamily (homologous_superfamily) [130-414]
- IPR001628: Zinc finger, nuclear hormone receptor-type (domain) [78-153]
- IPR047158: Retinoic acid receptor, ligand-binding domain (domain) [179-409]
- IPR001723: Nuclear hormone receptor (family) [142-386]
Sequence:
MFDCMDVLSVSPGQILDFYTASPSSCMLQEKALKACLSGFTQAEWQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPNSSGNTAEHSPSVSPSSVETSGVSQSPLLQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0140297 (DNA-binding transcription factor binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0016922 (nuclear receptor binding), GO:0042974 (nuclear retinoic acid receptor binding), GO:0046965 (nuclear retinoid X receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050793 (regulation of developmental process), GO:0008283 (cell population proliferation), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0031641 (regulation of myelination), GO:0061351 (neural precursor cell proliferation), GO:2000026 (regulation of multicellular organismal development), GO:0051960 (regulation of nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Solute carrier family 17 (Sodium phosphate), member 3, isoform CRA_b (A6KLK9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR011701: Major facilitator superfamily (family) [47-210]
- IPR050382: Major Facilitator Superfamily Sodium/Anion Cotransporter (family) [208-462]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [27-466]
Sequence:
MATVVELSPTSEQCEFVLGLPVNKKTPPRKVPSLCSMRYSIAFIAHICNFTLIAQNSIISITMVAMVNNTDQPSHLNSSTEWFPDGLNGDQHEASKHLSIKAPVYNWSPQTQGIIFSSVQYGMMLMQGPGGYLAGKLGTKKVVGIALLGSSLLTLCIPLAANLGLAFLLATRAVQGLTQGAGYGGQFALWQKWAPPNERSRLCSIAMSGSIGVVCCLLWLILVYDDPVSHPWISSPEKEYILSSLDQQFNSEEQPLPIKAMLKSLPLWSMCLCSMTHQWLVNTLIIYTPTYISSVFKVNIRDNGLLSSLPFFVAWVIGILGGLLADFLLSKNFRLITVRKIITILGNTPPAALVVALPYVQSSYIATTTFLTLSCGLSPLCQSGVYINALDIAPRYASLLMGTSRGLAHSSAVMVPIVAGFFLNQDSEFGWRNFFFVLFAINLFGLIIYLVFAKADIQEWARERKLTRL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015293 (symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015370 (solute:sodium symporter activity), GO:0005436 (sodium:phosphate symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0006812 (monoatomic cation transport), GO:0006817 (phosphate ion transport), GO:0030001 (metal ion transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045177 (apical part of cell), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098862 (cluster of actin-based cell projections), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0005903 (brush border), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0031526 (brush border membrane), GO:0031253 (cell projection membrane)
Protein: X-ray repair complementing defective repair in Chinese hamster cells 5, isoform CRA_b (A6KFI4)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR005161: Ku70/Ku80, N-terminal alpha/beta (domain) [9-223]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [2-228]
Sequence:
MAWSGNKAAVVLCMDVGVAMGNSFPGEESPLEQAKKVMTMFVQRQVFSESKDEIALVLYGTESTDNALAGKDQYQNITVHRHLMLPDFDLLEDIGNKIQPSSQQADFLDALIVCMDLIQRETIGKKFGKKHIEVFTDLSSPFSQDQLDIIICNLKKSSISLQFFLPFPIDKNGEPGETEDHDSSFDHCAPSFPQKGLTEQQKEGIHMVTRVMLSLEGKDGLDEIYSFR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0009991 (response to extracellular stimulus), GO:0010035 (response to inorganic substance), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0033554 (cellular response to stress), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:1901700 (response to oxygen-containing compound), GO:0031099 (regeneration), GO:0010033 (response to organic substance), GO:0010038 (response to metal ion), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0010243 (response to organonitrogen compound), GO:0031667 (response to nutrient levels), GO:0006325 (chromatin organization), GO:0014070 (response to organic cyclic compound), GO:0033273 (response to vitamin), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048678 (response to axon injury), GO:0031103 (axon regeneration), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120036 (plasma membrane bounded cell projection organization), GO:0061564 (axon development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Mediator of RNA polymerase II transcription, subunit 8 homolog (Yeast) (Predicted), isoform CRA_a (A6JZH9)
Organism: Rattus norvegicus (Rat)
InterPro domains:
Sequence:
MAHVTYLSFLEVHSRENAKWNKNQHQVSFNASLPAVSVDGSLHSQVICAELSNEIIFCSRLI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex)
Protein: Tetraspanin (B3STU1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Multi-pass membrane protein
InterPro domains:
- IPR000301: Tetraspanin, animals (family) [1-241]
- IPR018503: Tetraspanin, conserved site (conserved_site) [61-83]
- IPR048232: Tetraspanin-6/7, EC2 domain (domain) [105-208]
- IPR008952: Tetraspanin, EC2 domain superfamily (homologous_superfamily) [105-208]
- IPR018499: Tetraspanin/Peripherin (family) [10-233]
Sequence:
METKPVITCLKTLLIIYSFVFWITGAILLAVGVWGKLTLGTYISLIAENSTNAPYVLIGTGTTIVVFGLFGCFATCRGSPWMLKLYAMFLSLVFLAELVAGISGFVFRHEIKDTFLRTYTDAMQNYNGKDERSRAVDHVQRSLSCCGVQNYTNWSSSPYFLEHGIPPSCCMNETDCNPLDLHNLTVAATKVNQKGCYDLVTSFMETNMGIIAGVAFGIAFSQLIGMLLACCLSRFITANQYEMV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0060627 (regulation of vesicle-mediated transport), GO:0099149 (regulation of postsynaptic neurotransmitter receptor internalization), GO:0051049 (regulation of transport), GO:0030100 (regulation of endocytosis), GO:0048259 (regulation of receptor-mediated endocytosis), GO:0002090 (regulation of receptor internalization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: C-X-C motif chemokine (F7F001)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted
InterPro domains:
- IPR039809: Chemokine beta/gamma/delta (family) [3-93]
- IPR001811: Chemokine interleukin-8-like domain (domain) [27-88]
- IPR033899: CXC Chemokine domain (domain) [29-89]
- IPR001089: CXC chemokine (family) [29-85]
- IPR036048: Chemokine interleukin-8-like superfamily (homologous_superfamily) [14-91]
- IPR018048: CXC chemokine, conserved site (conserved_site) [30-75]
Sequence:
MKSVALFLMGIIFLDHCGVRGTLVIRNQRCSCISTSQGTFHYKSLKDLKQFAPSPNCNKTEIIATLKNGDQTCLDPDSARVKKLMKEWEKKISQKKKQKRGKNHQRSKKTRKAKTPHHPESKKTA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0140677 (molecular function activator activity), GO:0030545 (signaling receptor regulator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005126 (cytokine receptor binding), GO:0001664 (G protein-coupled receptor binding), GO:0005125 (cytokine activity), GO:0042379 (chemokine receptor binding), GO:0008009 (chemokine activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0048584 (positive regulation of response to stimulus), GO:0040017 (positive regulation of locomotion), GO:0040012 (regulation of locomotion), GO:0050921 (positive regulation of chemotaxis), GO:0032101 (regulation of response to external stimulus), GO:0050920 (regulation of chemotaxis), GO:0032103 (positive regulation of response to external stimulus), GO:0050927 (positive regulation of positive chemotaxis), GO:0050926 (regulation of positive chemotaxis), GO:0050930 (induction of positive chemotaxis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: RAS-related C3 botulinum substrate 2 (A6HSL3)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR005225: Small GTP-binding domain (domain) [38-157]
- IPR001806: Small GTPase (family) [1-193]
- IPR003578: Small GTPase Rho (family) [33-187]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [18-183]
Sequence:
MKCRPSSVWWWVMEPWARHAFSSATPPMPSPENTSPLFDNYSANVMVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKDIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQPTRQQKRPCSLL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0048771 (tissue remodeling), GO:0046849 (bone remodeling), GO:0030036 (actin cytoskeleton organization), GO:0016043 (cellular component organization), GO:0060249 (anatomical structure homeostasis), GO:0001894 (tissue homeostasis), GO:0006996 (organelle organization), GO:0045453 (bone resorption), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Phosphodiesterase (A6JPD3)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR023088: 3'5'-cyclic nucleotide phosphodiesterase (family) [175-359]
- IPR036971: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily (homologous_superfamily) [99-424]
- IPR023174: 3'5'-cyclic nucleotide phosphodiesterase, conserved site (conserved_site) [220-231]
- IPR003607: HD/PDEase domain (domain) [177-353]
- IPR002073: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain (domain) [104-427]
Sequence:
MIRMVKLVWKSKSELQATKPRGILENEDAFHGFPGDVRLRGQTGVPAERRGSYPFIDFRLLNNTTHSGEIGSKKKVRRLLSFQRHFHESRLLRGMTPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNSHGLIHHFKLDMVTLHRFLVMVQEDYHGHNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLENIQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGDLEQKFELEISPLCNQQKDSIPSIQIGFMTYIVEPLFREWARFTGNSTLSESMLNHLAHNKAQWKSLLSNQHRRRGSGQDPAGTAPETLEQTEGATP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity), GO:0004112 (cyclic-nucleotide phosphodiesterase activity), GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity), GO:0004115 (3',5'-cyclic-AMP phosphodiesterase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0035556 (intracellular signal transduction), GO:0019932 (second-messenger-mediated signaling), GO:0019935 (cyclic-nucleotide-mediated signaling), GO:0019933 (cAMP-mediated signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0036477 (somatodendritic compartment), GO:0044297 (cell body), GO:0043025 (neuronal cell body)