Protein: 2'-5' oligoadenylate synthase (S4R467)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm
InterPro domains:
- IPR018952: 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal (domain) [164-345]
- IPR006116: 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain (domain) [29-211]
- IPR043518: 2-5-oligoadenylate synthetase, N-terminal conserved site (conserved_site) [62-81]
- IPR002934: Polymerase, nucleotidyl transferase domain (domain) [38-111]
- IPR006117: 2-5-oligoadenylate synthetase, C-terminal conserved site (conserved_site) [295-305]
- IPR043519: Nucleotidyltransferase superfamily (homologous_superfamily) [1-201]
Sequence:
MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDPRR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016740 (transferase activity), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:1901265 (nucleoside phosphate binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0016779 (nucleotidyltransferase activity), GO:0003723 (RNA binding), GO:0032555 (purine ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0005524 (ATP binding), GO:0003725 (double-stranded RNA binding), GO:0032559 (adenyl ribonucleotide binding), GO:0070566 (adenylyltransferase activity), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0002683 (negative regulation of immune system process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0002253 (activation of immune response), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0048525 (negative regulation of viral process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0050792 (regulation of viral process), GO:0006950 (response to stress), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0060759 (regulation of response to cytokine stimulus), GO:0050777 (negative regulation of immune response), GO:0009968 (negative regulation of signal transduction), GO:0032103 (positive regulation of response to external stimulus), GO:0045069 (regulation of viral genome replication), GO:0044085 (cellular component biogenesis), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0005975 (carbohydrate metabolic process), GO:0060761 (negative regulation of response to cytokine stimulus), GO:0001817 (regulation of cytokine production), GO:0002218 (activation of innate immune response), GO:0031348 (negative regulation of defense response), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0001819 (positive regulation of cytokine production), GO:0031349 (positive regulation of defense response), GO:0009615 (response to virus), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0002764 (immune response-regulating signaling pathway), GO:0050790 (regulation of catalytic activity), GO:0010648 (negative regulation of cell communication), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0006952 (defense response), GO:0030522 (intracellular receptor signaling pathway), GO:0045071 (negative regulation of viral genome replication), GO:0010033 (response to organic substance), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:1903900 (regulation of viral life cycle), GO:0002757 (immune response-activating signaling pathway), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0002833 (positive regulation of response to biotic stimulus), GO:0031323 (regulation of cellular metabolic process), GO:0001818 (negative regulation of cytokine production), GO:0080090 (regulation of primary metabolic process), GO:0002832 (negative regulation of response to biotic stimulus), GO:0032102 (negative regulation of response to external stimulus), GO:0032682 (negative regulation of chemokine production), GO:0031347 (regulation of defense response), GO:1903555 (regulation of tumor necrosis factor superfamily cytokine production), GO:0045089 (positive regulation of innate immune response), GO:0002758 (innate immune response-activating signaling pathway), GO:0001959 (regulation of cytokine-mediated signaling pathway), GO:0032642 (regulation of chemokine production), GO:0045824 (negative regulation of innate immune response), GO:0010468 (regulation of gene expression), GO:0032479 (regulation of type I interferon production), GO:0022607 (cellular component assembly), GO:0002429 (immune response-activating cell surface receptor signaling pathway), GO:0002753 (cytosolic pattern recognition receptor signaling pathway), GO:0043933 (protein-containing complex organization), GO:0051252 (regulation of RNA metabolic process), GO:0001960 (negative regulation of cytokine-mediated signaling pathway), GO:0034340 (response to type I interferon), GO:0019221 (cytokine-mediated signaling pathway), GO:0010629 (negative regulation of gene expression), GO:0034097 (response to cytokine), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0045088 (regulation of innate immune response), GO:0032722 (positive regulation of chemokine production), GO:0071310 (cellular response to organic substance), GO:0051336 (regulation of hydrolase activity), GO:1903557 (positive regulation of tumor necrosis factor superfamily cytokine production), GO:0010628 (positive regulation of gene expression), GO:0043129 (surfactant homeostasis), GO:0043467 (regulation of generation of precursor metabolites and energy), GO:0032481 (positive regulation of type I interferon production), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:1901857 (positive regulation of cellular respiration), GO:0035456 (response to interferon-beta), GO:0002220 (innate immune response activating cell surface receptor signaling pathway), GO:0071357 (cellular response to type I interferon), GO:0002221 (pattern recognition receptor signaling pathway), GO:0065003 (protein-containing complex assembly), GO:0071345 (cellular response to cytokine stimulus), GO:0140888 (interferon-mediated signaling pathway), GO:0043457 (regulation of cellular respiration), GO:0060339 (negative regulation of type I interferon-mediated signaling pathway), GO:0032760 (positive regulation of tumor necrosis factor production), GO:0032648 (regulation of interferon-beta production), GO:0071637 (regulation of monocyte chemotactic protein-1 production), GO:0140894 (endolysosomal toll-like receptor signaling pathway), GO:2000341 (regulation of chemokine (C-X-C motif) ligand 2 production), GO:0032680 (regulation of tumor necrosis factor production), GO:0035455 (response to interferon-alpha), GO:0060338 (regulation of type I interferon-mediated signaling pathway), GO:0032728 (positive regulation of interferon-beta production), GO:0035458 (cellular response to interferon-beta), GO:0051259 (protein complex oligomerization), GO:0002752 (cell surface pattern recognition receptor signaling pathway), GO:0035457 (cellular response to interferon-alpha), GO:0060337 (type I interferon-mediated signaling pathway), GO:0140895 (cell surface toll-like receptor signaling pathway), GO:0034142 (toll-like receptor 4 signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005840 (ribosome), GO:0005634 (nucleus)