Protein: Histone deacetylase (A0A8M3B885)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events
Subcellular location: Nucleus
InterPro domains:
- IPR023696: Ureohydrolase domain superfamily (homologous_superfamily) [688-1068]
- IPR000286: Histone deacetylase HDAC (family) [835-970]
- IPR046949: Histone deacetylase 4/5/7/9 (family) [46-1125]
- IPR023801: Histone deacetylase domain (domain) [710-1028]
- IPR037138: Histone deacetylase domain superfamily (homologous_superfamily) [686-1072]
- IPR024643: Histone deacetylase, glutamine rich N-terminal domain (domain) [93-181]
Sequence:
MLLKPTVPGLCAMLQTIYETESCFSSDSTSSRERPVELLPQSRSTSMPSTVDVKTLLPSGMQSPVGGGGDQGGGSGGPVDLRTDPRLSALSAVDPSLREKQLQHELLLLKQQQELQKQLLFAEFQKQHEVLTRQHEVQLQEHLKQQQEILAAKRQQELEQKRKLEQQRHEEMEKQRLEQQLIMLRNKEKGAIASTEVKLKLQEFLLSKKEPGPGGLNHSFPQKCWGAHHTSLEQSSPPQSNTPGTPPSYKLPPLLGSYEGKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAIEISVSSMCSSAPGSGPSSPNSSNCAIAENGSSGSVPNIHAEQLRSLHQSLTGDGAPSPLSLYTSPSLPNISLGLPANAHITAPQKLSAQQEAERQTIQSLRQGGALTGKFISTSSLPTCLSTGAPHDPEPPAASNSHSSHSSLLQHVLLLEQARQQSALLAVPMYGQSPLVTGERVSNNMRTVNKLPRHRPLSRTQSAPLPQTPQALQHLVMQQQHQHFLEKQKHYQLNKILSKGTDLPRQPPTHPEETEEELTETAEMQDERGEGPDHVREGLQKDSSGETTPPSERIVPLKGESTESDLEEEDDEDEAVELRECDEDAPYGQYLDQQHVQQLNVFQASLSITGMPHRPLGRAQSSPVTSSLKGTTLNEVPIKHLFTTGLVYDTFMLKHQCMCGNTNIHPEHAGRIQSVWSRLQETGLLGRCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSGAVRMAVGCVIELAFKVAAGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLGVGKILIIDWDIHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGSGAPEEVGVGPGEGFNVNIAWTGGVEPPMGDVEYLTAFRTVVMPIANEFSPDVVLVSAGFDAVEGHQSPLGGYNVTAKCFGHLTKQLMKLAGGRVVLALEGGHDLTAICDASESCVEALLGDELNPLPLTVLQQKPCPKATASLERVIEIQSKHWTSLQRLAPTVGQSLLDAQRREKDEADTLTAMASLTVDNEQQTTSTETSRSAEEPMEEEPVL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0033558 (protein lysine deacetylase activity), GO:0019213 (deacetylase activity), GO:0004407 (histone deacetylase activity), GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0072001 (renal system development), GO:0001822 (kidney development), GO:0060993 (kidney morphogenesis), GO:0072114 (pronephros morphogenesis), GO:0048793 (pronephros development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)