lokahq/bioreason-rl huggingface dataset:
Protein: Mediator of RNA polymerase II transcription subunit 21 (A6IN28)
Organism: Rattus norvegicus (Rat)
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors
Subcellular location: Nucleus
InterPro domains:
- IPR021384: Mediator complex, subunit Med21 (family) [1-136]
- IPR037212: Mediator complex, subunit Med7/Med21-like (homologous_superfamily) [2-125]
Sequence:
MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDMLLEKIQSALADIAQSQLKTRSVTHSQSLPDS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex)
Protein: Desmuslin (Q810D0)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR039008: Intermediate filament, rod domain (domain) [10-322]
- IPR030634: Synemin (family) [1-1155]
- IPR018039: Intermediate filament protein, conserved site (conserved_site) [308-316]
Sequence:
MLSWRLQTSSEKAELQELNARLYEYVCRVRELERENLLLEEELRSRLSREDRWAEDQALYAEEARSLRQQLDELSWSTALAEGERDALRRELLDLQREGLEASTARGRLDAELEAQRRELEEALGARAALEALLGRLEAERRDLDAAHERQVRELRARASSLTMHFRARATGPAAPPPRLRDVHDSYALLVAESWRESMQLYEDEVRELEQALRRGQESRLQAEDEARLCAQEADALRNQALELEQLRARLEDELLRMREEYGMQAEERQRVIDSLEDEKDALTLAMADRLREYQELLQVKTGLSLEVATYRALLEGESNPEILIWTENIENVPRESRNTSYRYTDSVLQRKNEKNLFPRRKTPWAAVNHSSTLYSNGPGHLDSQTTTAVGNAARRGFLTSCYSSSATTSQQKPLEKTVSSQASLRPVIPTHGFLRNTDAQVKTFSHGTKAEGMGDTLTRRATESVITRESYRGHQGNVAAGAVNSTQSNERTVILGKKLETQATKEQERDRSGVVKLKPEEKMFDSKEKASEERNLRWEELTKLDARERESQHLRNEAKGKETLTGRSRKEREVPISLEVSRGSKSEVSTIHLQSSGRKDSANSREREVKTKETKFHLDGKDTAGSLQSDSTTETIAENIVTTILKQFTQSPGAEENVSSLPDTKVTYLDRKEFPGDRKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDVKEVGLKGKSTETVIGEMINLGLKGREGRAKVVNVEIVEEPMSYVGGGKVEFSTPFQVEEVDDVSPSPKGFIEEEEGEGETHMAFSMHQRQRTNQPQVNVPHVEEVTEAGDSEGEQSYFVSTPDEYPGGHDREDDGSVYGQIHIEEESTIRYSWQDEIAQGTWRRKARGDTGEEKHMKVLEVPSASLGGAFGSAHVKEEASGELHAEPTIIEKEIKIPHEFHTSIKGVFSSEPRHQLVEVIGQLEETLPERMKEELSALTRQSQGEPGSVSVDVKKVQSSAGGSVTLMAEVNLSQTVDADQLDLEELSRDEAGEIEKAVESVVRESLTKRSSPVPRSPDREDGEEAPAGGFLFKRWATRELYSPSGEKDDTDRVFHSSDQRVTQGPVSATVEVTSPTGFVQSHVLEDVSQSVRHVKLGPTEMWRTEQVSYGGPTSPVVEMGVSDTRAIRSWTRDTGSEVEAHSVSHHGGWRVAHSRDEQSASTSSQASAGDAHQARGEKGTEQAGFDKTVQLQRMVDQRSVASDEKKVALLYLDNEEEEEGEGWF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0050879 (multicellular organismal movement), GO:0003012 (muscle system process), GO:0050877 (nervous system process), GO:0050881 (musculoskeletal movement), GO:0050905 (neuromuscular process), GO:0003009 (skeletal muscle contraction), GO:0006936 (muscle contraction), GO:0006941 (striated muscle contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005882 (intermediate filament), GO:0045111 (intermediate filament cytoskeleton)
Protein: 5'-nucleotidase, cytosolic IA (Predicted) (A6IS21)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR010394: 5-nucleotidase (family) [11-357]
Sequence:
MEPRQPPEAREPGPGAETAAVPRWEEAKTFYDNLSPKKKPKSPKPQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNKQLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVREAIDEGIAAATIFSPSKDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQNPRREKQSLGAQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0008252 (nucleotidase activity), GO:0008253 (5'-nucleotidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:1901657 (glycosyl compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0009116 (nucleoside metabolic process), GO:0009119 (ribonucleoside metabolic process), GO:0042278 (purine nucleoside metabolic process), GO:0046128 (purine ribonucleoside metabolic process), GO:0046085 (adenosine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Syntrophin, acidic 1 (A6KHY5)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cytoplasm, cytoskeleton
InterPro domains:
- IPR001849: Pleckstrin homology domain (domain) [6-263]
- IPR015482: Syntrophin (family) [1-340]
- IPR041428: Syntrophin, split Pleckstrin homology (PH) domain (domain) [204-264]
- IPR036034: PDZ superfamily (homologous_superfamily) [72-178]
- IPR001478: PDZ domain (domain) [81-164]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [2-264]
Sequence:
MASGRRAPRTGLLELRSGAGSGAGGERWQRVLLTLAEDALTVSPADGEPGPEPEPAQLNGAAEPGAASPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQALKKTGKEVVLEVKYMKEVSPYFKNSAGGTSVGWDSPPASPLQRQPSSPGPQPRNLNEAKHVSLKMAYVSRRCTPTDPEPRYLEICAADGQDTLFLRAKDEASARSWAGAIQAQISTFIPWVKDELQALLTATGTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLLYCSLPQTREALSRPARTAPLIATSSLPWPRPTPRPHAWPSALHTGWCTQALPRAQCPMMQSSPLPCARVHATVWTLTCSVWSRRRSWQPGPDSWWMAVTGLLKVCKKCLQPARGMAVPATYPCTLTRASHCGQLSQEQPELCCSDSPLRNFRCHQMMA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding), GO:0030165 (PDZ domain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065008 (regulation of biological quality), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0060627 (regulation of vesicle-mediated transport), GO:0099149 (regulation of postsynaptic neurotransmitter receptor internalization), GO:0051049 (regulation of transport), GO:0051128 (regulation of cellular component organization), GO:0060627 (regulation of vesicle-mediated transport), GO:0099149 (regulation of postsynaptic neurotransmitter receptor internalization), GO:0030100 (regulation of endocytosis), GO:0048259 (regulation of receptor-mediated endocytosis), GO:0002090 (regulation of receptor internalization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005886 (plasma membrane), GO:0045202 (synapse), GO:0042383 (sarcolemma), GO:0031594 (neuromuscular junction)
Protein: RCG24674, isoform CRA_e (A6JBT7)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR039008: Intermediate filament, rod domain (domain) [10-322]
- IPR030634: Synemin (family) [1-1155]
- IPR018039: Intermediate filament protein, conserved site (conserved_site) [308-316]
Sequence:
MLSWRLQTSSEKAELQELNARLYEYVCRVRELERENLLLEEELRSRLSREDRWAEDQALYAEEARSLRQQLDELSWSTALAEGERDALRRELLDLQREGLEASTARGRLDAELEAQRRELEEALGARAALEALLGRLEAERRDLDAAHERQVRELRARASSLTMHFRARATGPAAPPPRLRDVHDSYALLVAESWRESMQLYEDEVRELEQALRRGQESRLQAEDEARLCAQEADALRNQALELEQLRARLEDELLRMREEYGMQAEERQRVIDSLEDEKDALTLAMADRLREYQELLQVKTGLSLEVATYRALLEGESNPEILIWTENIENVPRESRNTSYRYTDSVLQRKNEKNLFPRRKTPWAAVNHSSTLYSNGPGHLDSQTTTAVGNAARRGFLTSCYSSSATTSQQKPLEKTVSSQASLRPVIPTHGFLRNTDAQVKTFSHGPKAEGMGDTLTRRATESVITRESYRGHQGNVAAGAVNSTQSNERTVILGKKLETQATKEQERDRSGVVKLKPEEKMFDSKEKASEERNLRWEELTKLDARERESQHLRNEAKGKETLTGRSRKEREVPISLEVSRGSKSEVSTIHLQSSGRKDSANSREREVKTKETKFHLDGKDTAGSLQSDSTTETIAENIVTTILKQFTQSPGAEENVSSLPDTKVTYLDRKEFPGDRKTKTEIVMESKLTEDVDVSDEAGLDYLLSKDVKEVGLKGKSTETVIGEMINLGLKGREGRAKVVNVEIVEEPMSYVGGGKVEFSTPFQVEEVDDVSPSPKGFIEEEEGEGETHMAFSMHQRQRTNQPQVNVPHVEEVTEAGDSEGEQSYFVSTPDEYPGGHDREDDGSVYGQIHIEEESTIRYSWQDEIAQGTWRRKARGDTGEEKHMKVLEVPSASLGGAFGSAHVKEEASGELHAEPTIIEKEIKIPHEFHTSIKGVFSSEPRHQLVEVIGQLEETLPERMKEELSALTRQSQGEPGSVSVDVKKVQSSAGGSVTLMAEVNLSQTVDADQLDLEELSRDEAGEIEKAVESVVRESLTKRSSPVPRSPDREDGEEAPAGGFLFKRWATRELYSPSGEKDDTDRVFHSSDQRVTQGPVSATVEVTSPTGFVQSHVLEDVSQSVRHVKLGPTEMWRTEQVSYGGPTSPVVEMGVSDTRAIRSWTRDTGSEVEAHSVSHHGGWRVAHSRDEQSASTSSQASAGDAHQARGEKGTEQAGFDKTVQLQRMVDQRSVASDEKKVALLYLDNEEEEEGEGWF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0050879 (multicellular organismal movement), GO:0003012 (muscle system process), GO:0050877 (nervous system process), GO:0050881 (musculoskeletal movement), GO:0050905 (neuromuscular process), GO:0003009 (skeletal muscle contraction), GO:0006936 (muscle contraction), GO:0006941 (striated muscle contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005882 (intermediate filament), GO:0045111 (intermediate filament cytoskeleton)
Protein: Similar to CGI-84 protein (Predicted) (A6K4X0)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein
InterPro domains:
- IPR005024: Snf7 family (family) [5-210]
Sequence:
MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACRVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0008289 (lipid binding), GO:0043168 (anion binding), GO:0005543 (phospholipid binding), GO:0005546 (phosphatidylinositol-4,5-bisphosphate binding), GO:0035091 (phosphatidylinositol binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:1902936 (phosphatidylinositol bisphosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065008 (regulation of biological quality), GO:0023051 (regulation of signaling), GO:0050794 (regulation of cellular process), GO:0050803 (regulation of synapse structure or activity), GO:0099177 (regulation of trans-synaptic signaling), GO:0051128 (regulation of cellular component organization), GO:0010646 (regulation of cell communication), GO:0050807 (regulation of synapse organization), GO:0050804 (modulation of chemical synaptic transmission), GO:0099175 (regulation of postsynapse organization), GO:1905244 (regulation of modification of synaptic structure), GO:0099159 (regulation of modification of postsynaptic structure)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0098794 (postsynapse), GO:0030054 (cell junction), GO:0045202 (synapse), GO:0099572 (postsynaptic specialization), GO:0098984 (neuron to neuron synapse), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0032279 (asymmetric synapse)
Protein: Arylsulfatase A, isoform CRA_b (A6K7N3)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR000917: Sulfatase, N-terminal (domain) [2-95]
- IPR050738: Sulfatase enzyme (family) [2-231]
- IPR017850: Alkaline-phosphatase-like, core domain superfamily (homologous_superfamily) [1-250]
Sequence:
MELDGAVGALMTAVGDLGLLGETLVIFTADNGPELMRMSDGGCSGLLRCGKGTTFEGGVREPALVYWPGHITPGVTHELASSLDLLPTLAALTGAPLPNITLDGVDISPLLLGTGKSPRNSVFFYPPFPDEIHGVFAVRNGKYKAHFFTQGSAHSDTTPDPACHAANRLTAHEPPLLYDLSKDPGENYNLLDSTEEVSPEALQALKHIELLKAEYDAAMTFSPSQIAKGEDPALQICCQPSCTPHPVCCHCPDSHS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0008484 (sulfuric ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0007568 (aging)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Folate binding protein (Q9JL02)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR004269: Folate receptor (family) [3-232]
- IPR018143: Folate receptor-like (domain) [34-209]
Sequence:
MAHLMAGQWLLLLMWMAECAQSRATRARTELLNVCMDAKHHKEKPGPEDKLHDQCSPWKTNACCSTNTSQEDTKDISYLYRFNWNHCGTMTPECKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERILDVPLCKEDCVLWWEDCKSSFTCKSNWLKGWNWTSGHNECPVGASCHPFTFYFPTPAVLCEKIWSHSYKLSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAEVMSGAGLREAWLLVCSLSLVLFCVVS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:0033218 (amide binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0072341 (modified amino acid binding), GO:0019842 (vitamin binding), GO:0043168 (anion binding), GO:0043177 (organic acid binding), GO:0005542 (folic acid binding), GO:0031406 (carboxylic acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0003008 (system process), GO:0003014 (renal system process), GO:0009991 (response to extracellular stimulus), GO:1901700 (response to oxygen-containing compound), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0070293 (renal absorption), GO:0014070 (response to organic cyclic compound), GO:0010243 (response to organonitrogen compound), GO:0033273 (response to vitamin), GO:0031667 (response to nutrient levels), GO:0051593 (response to folic acid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098862 (cluster of actin-based cell projections), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0005903 (brush border), GO:0005886 (plasma membrane), GO:0031526 (brush border membrane), GO:0031253 (cell projection membrane)
Protein: RCG56007, isoform CRA_a (A6IAW7)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR034827: TIA-1, RNA recognition motif 1 (domain) [8-81]
- IPR034496: TIAR, RNA recognition motif 3 (domain) [214-286]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [1-290]
- IPR003954: RNA recognition motif domain, eukaryotic-type (domain) [8-282]
- IPR000504: RNA recognition motif domain (domain) [7-286]
- IPR034830: TIA-1, RNA recognition motif 2 (domain) [104-181]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [6-284]
Sequence:
MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVSQSSPGNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFIRFSSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPPAYGQWGQWYGNAQQIGQYVPNGWQVPAYGMYGQPWSQQGFNQTQSSAPWMGPNYSVPPPQGQNGGMLPNQPAGYRVAGYETQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding), GO:0035925 (mRNA 3'-UTR AU-rich region binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0010941 (regulation of cell death), GO:0010942 (positive regulation of cell death), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:1904037 (positive regulation of epithelial cell apoptotic process), GO:1904035 (regulation of epithelial cell apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0010494 (cytoplasmic stress granule), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Hairy/enhancer-of-split related with YRPW motif 2 (A6JUS1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus
InterPro domains:
- IPR003650: Orange domain (domain) [119-166]
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [48-109]
- IPR050370: Hairy and Enhancer of Split/HEY-related (family) [43-332]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [42-106]
Sequence:
MKRPCEETTSESDLDETIDVGSENNYSGHSASSVMRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALATDFMSIGFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLSTCASQREAAVMTSSMSHHHHPLHPHHWAAAFHHLPTSLLQPNGLHTSESTPCRLSTSSEVPPAHGSALLTATFAHADSALRMPSTGTVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPSNAAAAAAVAAATAISPPLSVSAASSPQQTSSGTNSKPYRPWGTEVGAF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0003676 (nucleic acid binding), GO:0019899 (enzyme binding), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0140297 (DNA-binding transcription factor binding), GO:0003677 (DNA binding), GO:0042826 (histone deacetylase binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0051716 (cellular response to stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway), GO:0048513 (animal organ development), GO:0048731 (system development), GO:0007507 (heart development), GO:0072359 (circulatory system development), GO:0007219 (Notch signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)