Protein: receptor protein-tyrosine kinase (A6JZI8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single- pass type I membrane protein
InterPro domains:
- IPR003961: Fibronectin type III (domain) [447-738]
- IPR050122: Receptor Tyrosine Kinase (family) [131-1010]
- IPR002049: Laminin-type EGF domain (domain) [228-266]
- IPR000742: EGF-like domain (domain) [224-346]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [838-1007]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [974-986]
- IPR013151: Immunoglobulin-like beta-sandwich domain (domain) [134-437]
- IPR000719: Protein kinase domain (domain) [838-1022]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [126-738]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [434-736]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [134-453]
- IPR007110: Immunoglobulin-like domain (domain) [352-443]
- IPR017441: Protein kinase, ATP binding site (binding_site) [844-869]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [838-1019]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [831-1002]
- IPR003599: Immunoglobulin domain subtype (domain) [132-445]
Sequence:
MVWWGSPFLLPILFLASHVGASVDLTLLANLRITEPQRFFLTCVSGEAGAGRSSDVWGPPLLLEKDDRIVRTFPPGQPLHLTRNGSHQVTLRGFSKPSDLVGVFSCVGGAGTRRTRVLYVHNSPGAHLFPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKNNGSYFHTLDWHEAHDGRFQLQLQNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCEAGRWGPGCVKDCPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGTAGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNVATELEFNLGTMPRINCAAAGNPFPVRGSMELRKPDGTMLLSTKAIVEPDRTTAEFEVPRLTLGDSGFWECRVSTSGGQDSQRFKVNVKVPPVPLTAPRLLAKQSRQLVVSPLVSFGGDGPISSVRLHYRPQDSMITWSAIVVDPSENVTLMNLKPRTGYNVRVQLSRPGEGGEGAWGPSTLMTTDCPEPLLQPWVESWNVEGPDRLRVSWSLPSVPLSGDGFLLRLWDGARGQERRENISSPQARTALLTGLTPGTHYQLDVRLYHCTLLGPASPSAHVHLPLSGPPAPRHLRAQALSDSEIRLMWQHPEAPPGPISKYIVEIQVAGGSGDPQWMDVDKPEETSTTVRGLNASTRYLFRVRASVQGLGDWSNTVEETTLGNGLQSASPVQESRVAEDGLDQQLVLAVVGSVSATCLTILAALLALVCIRRSCLHRRHTFTYQSGSGEETILQFSSGTLTLTRRPKPQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMARPSSCALDGH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019838 (growth factor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0001570 (vasculogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)