Protein: CHK2 checkpoint homolog (S. pombe), isoform CRA_a (A0A0G2K8L3)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [346-358]
- IPR000719: Protein kinase domain (domain) [223-489]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [95-208]
- IPR000253: Forkhead-associated (FHA) domain (domain) [115-194]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [215-505]
Sequence:
MKSHQSHGSTSSKAHDSASCSQSQGGFSQSQGTPSQLHDLSQYQGASSSSTSTVPSSSQSSHSSSGTLSSLETVSTQELCSIPEDQEPEEPGPTPWARLWALQDGFSNLDCVNDNYWFGRDKSCEYCFDGPLLKRTDKYRTYSKKHFRIFREMGPKNCYIVYLEDHSGNGTFVNTELIGKGKRCPLSNNSEIALSLCRNKVFVFFDLTVDDQSVYPKELRDEYIMSKTLGSGACGEVKMAFERKTCKKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLNHPCIIKIKDVFDVEDYYIVLELMEGGELFDRVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLISNGTAGYSRAVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKYNLIPEVWTDVSEKALDLVKKLLVVDPKARLTTEEALSHPWLQDEHMKKKFQDLLVQEKNLVPLPLAPAQTSGQKRPLELEAEDAESSKRLAVCKAVL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010942 (positive regulation of cell death), GO:0010648 (negative regulation of cell communication), GO:0090068 (positive regulation of cell cycle process), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0035556 (intracellular signal transduction), GO:0009410 (response to xenobiotic stimulus), GO:0080134 (regulation of response to stress), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0010948 (negative regulation of cell cycle process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0045787 (positive regulation of cell cycle), GO:0006793 (phosphorus metabolic process), GO:0051726 (regulation of cell cycle), GO:2001021 (negative regulation of response to DNA damage stimulus), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0045786 (negative regulation of cell cycle), GO:0080090 (regulation of primary metabolic process), GO:0010564 (regulation of cell cycle process), GO:0071466 (cellular response to xenobiotic stimulus), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0000075 (cell cycle checkpoint signaling), GO:1901989 (positive regulation of cell cycle phase transition), GO:0051246 (regulation of protein metabolic process), GO:0071310 (cellular response to organic substance), GO:0006974 (cellular response to DNA damage stimulus), GO:0042770 (signal transduction in response to DNA damage), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0006796 (phosphate-containing compound metabolic process), GO:1902532 (negative regulation of intracellular signal transduction), GO:2001020 (regulation of response to DNA damage stimulus), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:1901987 (regulation of cell cycle phase transition), GO:0051247 (positive regulation of protein metabolic process), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:1901988 (negative regulation of cell cycle phase transition), GO:0031570 (DNA integrity checkpoint signaling), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:2000001 (regulation of DNA damage checkpoint), GO:0031399 (regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0006468 (protein phosphorylation), GO:0018193 (peptidyl-amino acid modification), GO:1901977 (negative regulation of cell cycle checkpoint), GO:0071407 (cellular response to organic cyclic compound), GO:0019220 (regulation of phosphate metabolic process), GO:0016310 (phosphorylation), GO:1901976 (regulation of cell cycle checkpoint), GO:0031401 (positive regulation of protein modification process), GO:0000077 (DNA damage checkpoint signaling), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:2000209 (regulation of anoikis), GO:0042327 (positive regulation of phosphorylation), GO:0018105 (peptidyl-serine phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0018209 (peptidyl-serine modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)