Protein: Forkhead box O3a (Predicted) (A6K6Z2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus
InterPro domains:
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [152-238]
- IPR001766: Fork head domain (domain) [154-250]
- IPR030456: Fork head domain conserved site 2 (conserved_site) [205-211]
- IPR032068: FOXO protein, KIX-binding domain (domain) [432-510]
- IPR032067: FOXO protein, transactivation domain (domain) [603-643]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [152-242]
Sequence:
MAEAPASPVPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEDDDEDDEDSGGRGSSAMVIGGGVSSALGSGLLLEDSARLLSPGGQDLGTGPASSAGALSGGTQTQLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQAAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPILASTELDDVQDDDGPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLAENLMDDLLDNIALPPSQASPPGGLMQRSSSFPYTAKSSGLGSPTSSFNSTVFGPASLNSLRQSPMQTIQENRPATFSSVSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNARRNVMLRNDPMMSFAAQPTQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSDSSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSASANLPVMGHDKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0001221 (transcription coregulator binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0048878 (chemical homeostasis), GO:0050793 (regulation of developmental process), GO:0019725 (cellular homeostasis), GO:0009719 (response to endogenous stimulus), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007568 (aging), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0001666 (response to hypoxia), GO:0010942 (positive regulation of cell death), GO:0012501 (programmed cell death), GO:1902884 (positive regulation of response to oxidative stress), GO:0009410 (response to xenobiotic stimulus), GO:0080134 (regulation of response to stress), GO:0070482 (response to oxygen levels), GO:0080135 (regulation of cellular response to stress), GO:0070848 (response to growth factor), GO:0033500 (carbohydrate homeostasis), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0009891 (positive regulation of biosynthetic process), GO:0009991 (response to extracellular stimulus), GO:0055082 (intracellular chemical homeostasis), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0045596 (negative regulation of cell differentiation), GO:0033554 (cellular response to stress), GO:0009889 (regulation of biosynthetic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0035902 (response to immobilization stress), GO:0071456 (cellular response to hypoxia), GO:0071417 (cellular response to organonitrogen compound), GO:1901652 (response to peptide), GO:0045664 (regulation of neuron differentiation), GO:0009743 (response to carbohydrate), GO:0097305 (response to alcohol), GO:1901654 (response to ketone), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:0071453 (cellular response to oxygen levels), GO:0043067 (regulation of programmed cell death), GO:0071310 (cellular response to organic substance), GO:0043068 (positive regulation of programmed cell death), GO:1990089 (response to nerve growth factor), GO:1903209 (positive regulation of oxidative stress-induced cell death), GO:0048545 (response to steroid hormone), GO:1901699 (cellular response to nitrogen compound), GO:0045665 (negative regulation of neuron differentiation), GO:1900407 (regulation of cellular response to oxidative stress), GO:0032870 (cellular response to hormone stimulus), GO:1903201 (regulation of oxidative stress-induced cell death), GO:0010243 (response to organonitrogen compound), GO:1903428 (positive regulation of reactive oxygen species biosynthetic process), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0036293 (response to decreased oxygen levels), GO:0042593 (glucose homeostasis), GO:1902882 (regulation of response to oxidative stress), GO:0006915 (apoptotic process), GO:1903426 (regulation of reactive oxygen species biosynthetic process), GO:0014070 (response to organic cyclic compound), GO:2000379 (positive regulation of reactive oxygen species metabolic process), GO:0001678 (intracellular glucose homeostasis), GO:1901701 (cellular response to oxygen-containing compound), GO:0071363 (cellular response to growth factor stimulus), GO:1901655 (cellular response to ketone), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0071548 (response to dexamethasone), GO:0031960 (response to corticosteroid), GO:0071322 (cellular response to carbohydrate stimulus), GO:0071333 (cellular response to glucose stimulus), GO:1901031 (regulation of response to reactive oxygen species), GO:0034284 (response to monosaccharide), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:1901653 (cellular response to peptide), GO:0036294 (cellular response to decreased oxygen levels), GO:0071383 (cellular response to steroid hormone stimulus), GO:1904645 (response to amyloid-beta), GO:1990090 (cellular response to nerve growth factor stimulus), GO:0097306 (cellular response to alcohol), GO:1903205 (regulation of hydrogen peroxide-induced cell death), GO:0051412 (response to corticosterone), GO:1904646 (cellular response to amyloid-beta), GO:0071326 (cellular response to monosaccharide stimulus), GO:0051385 (response to mineralocorticoid), GO:0051384 (response to glucocorticoid), GO:0071384 (cellular response to corticosteroid stimulus), GO:1904037 (positive regulation of epithelial cell apoptotic process), GO:0009746 (response to hexose), GO:1904035 (regulation of epithelial cell apoptotic process), GO:2000351 (regulation of endothelial cell apoptotic process), GO:0071331 (cellular response to hexose stimulus), GO:0071385 (cellular response to glucocorticoid stimulus), GO:0009749 (response to glucose), GO:0071389 (cellular response to mineralocorticoid stimulus), GO:2000353 (positive regulation of endothelial cell apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)