Protein: LIM and senescent cell antigen-like-containing domain protein (A6K3T1)
Organism: Rattus norvegicus (Rat)
Function: Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors
Subcellular location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein
InterPro domains:
- IPR001781: Zinc finger, LIM-type (domain) [20-322]
- IPR047946: LIM and senescent cell antigen-like-containing domain protein 1/2-like (family) [8-333]
- IPR047944: LIMS1/2-like, LIM domain 1 (domain) [22-80]
- IPR017351: LIM and senescent cell antigen-like-containing domain protein 1-4-like (family) [11-333]
Sequence:
MLGVAAGMTNSNMANALASATCERCKGGFDPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDVVSALNKAWCVSCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEKFPLELKKRLKKLSETLGRK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0023056 (positive regulation of signaling), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007163 (establishment or maintenance of cell polarity), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0007155 (cell adhesion), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0045597 (positive regulation of cell differentiation), GO:0010942 (positive regulation of cell death), GO:0060548 (negative regulation of cell death), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0008285 (negative regulation of cell population proliferation), GO:0070848 (response to growth factor), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0051130 (positive regulation of cellular component organization), GO:0098609 (cell-cell adhesion), GO:0009891 (positive regulation of biosynthetic process), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0042391 (regulation of membrane potential), GO:0009889 (regulation of biosynthetic process), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0010647 (positive regulation of cell communication), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0008284 (positive regulation of cell population proliferation), GO:0022604 (regulation of cell morphogenesis), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0031344 (regulation of cell projection organization), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:1990089 (response to nerve growth factor), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0060251 (regulation of glial cell proliferation), GO:0050769 (positive regulation of neurogenesis), GO:0051960 (regulation of nervous system development), GO:0060252 (positive regulation of glial cell proliferation), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0031346 (positive regulation of cell projection organization), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0031345 (negative regulation of cell projection organization), GO:0034330 (cell junction organization), GO:0071363 (cellular response to growth factor stimulus), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0050772 (positive regulation of axonogenesis), GO:0043066 (negative regulation of apoptotic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0043523 (regulation of neuron apoptotic process), GO:0034329 (cell junction assembly), GO:0051057 (positive regulation of small GTPase mediated signal transduction), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0014015 (positive regulation of gliogenesis), GO:0050767 (regulation of neurogenesis), GO:0043410 (positive regulation of MAPK cascade), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0050767 (regulation of neurogenesis), GO:0050808 (synapse organization), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0010975 (regulation of neuron projection development), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)