Protein: Sodium/potassium exporting P-type ATPase 1 (O13397)
Organism: Schwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)
Function: Catalyzes the hydrolysis of ATP coupled with the export of sodium and potassium from the cell. May be an inefficient potassium exporter. May transport other cations such as lithium (By similarity). Sodium/potassium efflux ATPases are involved in salt tolerance and maintaining the membrane potential across the plasma membrane in high salinity (Na+) or alkaline (K+) environments
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR023214: HAD superfamily (homologous_superfamily) [380-394]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [385-391]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [389-627]
- IPR006068: Cation-transporting P-type ATPase, C-terminal (domain) [818-1017]
- IPR006414: P-type ATPase, subfamily IID (family) [27-1023]
- IPR044492: P-type ATPase, haloacid dehalogenase domain (domain) [364-780]
- IPR059000: P-type ATPase, A domain (domain) [134-249]
- IPR001757: P-type ATPase (family) [283-809]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [25-1023]
- IPR004014: Cation-transporting P-type ATPase, N-terminal (domain) [25-99]
- IPR036412: HAD-like superfamily (homologous_superfamily) [382-837]
- IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [136-248]
Sequence:
MTPSIGYVDEDENGQKSKFLRSSDDPYRLSIEEVIEKFETHLENGLSDEQAKSKLAKVGLNNLGADEKISISKILAHQIFNAMVLVLIISLIIALAIKDWISGGVIGFVVFINIFVGFIQELKAEKTMGSLRSLSSPMARALRNGVDSNINAEEVVPGDIIHIKVGDTIPADLRLVDCMNLETDEALLTGESLPVAKDHEEIYDYGAPIPVGDRLNMAFSSSIVAKGRGTGIVVATGLDTEIGKIAKSLKNNDDAVVVKVDKSLNPSTKDYLIAVIKTTKNIIFNVLGTNVGTPLQRKLSWLAILLFWVAVLFAIVVMASQEMRVNRNVAIYAICVALSMIPSSLVVVLTITMAIGAQVMVTKNVIVRKLDSLEALGGINDICSDKTGTLTMGKMIARKVWIPNVGSYLVQNSNEPFNPTVGDISFNENSPKFIKETDDELDFIPHLPSPTPILFEKWLHIATLANIASLNQIQNEMDGSIEWEAHGDATEIAINVFTTRLGYTRDKLIGDSLEHLNEFPFDSSIKRMSTVYKDKDGNSTVYTKGAVERVLSCCKYWYNPELTALSEEDKLLIESNMNALSSEGLRVLAFAQREINISKENVSNREVVESNLIFLGLIGIYDPPRPESAKSVKLCHKAGINVHMLTGDHPGTAKAIAQEVGILPHNLYHYREEVVKVMVMIANEFDSLSDDEIDNLPVLPLVIARCAPQTKVRMIEALHRRGKFVAMTGDGVNDSPSLKKADVGIAMGLNGSDVAKDASDIVLTDDNFASILNAIEEGRRMSSNIQKFVLQLLAENVAQALYLMIGLAFIDKSGYSVFPLSPVEVLWIIVVTSCFPAMGLGQEKASHDILEQPPNATIFTWEVIIDMIAYGFWMAVCCLVCFVCIVYGKGDGSLGENCNEGSDTGCNLVFRGRSGAFAAFTWCALLLAWECIHLRLSFFKMRPELENPWWKQLAIDLWDNQFLFWSVMGAIVSVFPVVYIPVINNKVFLHAPIGYEWGLAVAFTILFLIGAEGWKWFKRVYYRKSNANNPEYDLERNDPFKEYSSFSKSNTMEIV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0140358 (P-type transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:0008556 (P-type potassium transmembrane transporter activity), GO:0008554 (P-type sodium transporter activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015662 (P-type ion transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0005391 (P-type sodium:potassium-exchanging transporter activity), GO:0046873 (metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0055074 (calcium ion homeostasis), GO:0006874 (intracellular calcium ion homeostasis), GO:0006816 (calcium ion transport), GO:0006812 (monoatomic cation transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:0070509 (calcium ion import)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)