Protein: E1 ubiquitin-activating enzyme (A7LAC4)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR018075: Ubiquitin-activating enzyme E1 (family) [48-1054]
- IPR018965: Ubiquitin-activating enzyme E1, C-terminal (domain) [921-1052]
- IPR045886: ThiF/MoeB/HesA family (family) [389-1021]
- IPR032418: Ubiquitin-activating enzyme E1, FCCH domain (domain) [226-295]
- IPR018074: Ubiquitin-activating enzyme E1, conserved site (conserved_site) [410-418]
- IPR000594: THIF-type NAD/FAD binding fold (domain) [450-937]
- IPR032420: Ubiquitin-activating enzyme E1, four-helix bundle (domain) [297-365]
- IPR042449: Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 (homologous_superfamily) [44-162]
- IPR042302: Ubiquitin-activating enzyme E1, FCCH domain superfamily (homologous_superfamily) [214-294]
- IPR035985: Ubiquitin-activating enzyme-like (homologous_superfamily) [48-939]
- IPR019572: Ubiquitin-activating enzyme, SCCH domain (domain) [637-883]
- IPR038252: Ubiquitin-activating enzyme E1, C-terminal domain superfamily (homologous_superfamily) [956-1056]
- IPR033127: Ubiquitin-activating enzyme E1, Cys active site (active_site) [629-637]
- IPR042063: Ubiquitin-activating enzyme E1, SCCH domain (homologous_superfamily) [622-890]
- IPR000011: Ubiquitin/SUMO-activating enzyme E1-like (family) [75-724]
Sequence:
ENISGWMPCLEWARDEFEGLFKQSAENVNQYLMDPKFMERTLQLAGTQPLEVLEAIQCSLVLQRPQTWADCVTWAYQHWHTQYSHNIQQLLHNFPPDQLTSSGVLFWSGPKRCPHPLTFDTNNPLHLDYVMAAANLFAQTYGLEGSQDCAAVTTLLQSLPAPKFAPKSGIRIHVSEQELQSTSATVDDSHLEELKTSLPTPDRMLGFKMHPIDFEKDDDSNFHMDFIVAASNLRAENYDIPPADRHKSKLIAGKIIPAIATTTSAVVGLVCLELYKVVQGHQQLDSFKNSFINLALPFFSFSAPLAPGYHQYYDRKWTLWDRFDVQGLQPSGEEMTLKQFLDYFKTEHKLEITILSQGVSMLYSFFMPATKPQERLDQPMTEIVSRVSKRKLGQHVKSLVFELCCNNESGDDIEVPYVRYIIG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016874 (ligase activity), GO:0008641 (ubiquitin-like modifier activating enzyme activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016877 (ligase activity, forming carbon-sulfur bonds)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006281 (DNA repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)