Protein: Protoheme IX farnesyltransferase, mitochondrial (Q9Y7Y4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Converts protoheme IX and farnesyl diphosphate to heme O
Subcellular location: Mitochondrion membrane; Multi-pass membrane protein
InterPro domains:
- IPR030470: UbiA prenyltransferase conserved site (conserved_site) [138-160]
- IPR006369: Protohaem IX farnesyltransferase (family) [55-371]
- IPR000537: UbiA prenyltransferase (family) [100-349]
- IPR044878: UbiA prenyltransferase superfamily (homologous_superfamily) [92-240]
- IPR016315: Protohaem IX farnesyltransferase, mitochondria (family) [53-383]
Sequence:
MFHILNKGSSKSCIYTRPCLKRFYHQHYEHTGKLSRTFFSPTHIKYNRLSTLDTSTSTANAAPDPQVLTFLSKRMQAAPLYPKPSAFLELGKPRLTVLVVLSTMSSYALAPYPGLSFNTLAWLTMGTALCSISANAFNQSMEPMLDCQMARTRSRPIPRGAIRPEYAWLFATLTGIAGTSMSFLVNPTVGWLGLGNIVLYMGIYTPLKRISIVNTWVGSLVGAIPPLMGWAACSGGDLLSHPGGLITAAMLFAWQFPHFNAFSTMVKDDYKKCGYQMMAWKNPALNARVSLRYALAFLPLSYAYISTGLVGPWYAVPATGTNMFLIARAWKFYRNRNYQNARSLFFASLLHLPLLFTLTLACHMIKVWNDSDSKNPVLGSEEDTLKY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0004659 (prenyltransferase activity), GO:0004311 (farnesyltranstransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0042440 (pigment metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044085 (cellular component biogenesis), GO:0046483 (heterocycle metabolic process), GO:0046148 (pigment biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0042168 (heme metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0043933 (protein-containing complex organization), GO:0033013 (tetrapyrrole metabolic process), GO:0006783 (heme biosynthetic process), GO:0022607 (cellular component assembly), GO:0006778 (porphyrin-containing compound metabolic process), GO:0033014 (tetrapyrrole biosynthetic process), GO:0065003 (protein-containing complex assembly), GO:0006779 (porphyrin-containing compound biosynthetic process), GO:0017004 (cytochrome complex assembly), GO:0008535 (respiratory chain complex IV assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)