Protein: Transcription and mRNA export factor ENY2 (A6HRB2)
Organism: Rattus norvegicus (Rat)
Function: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor- mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery
Subcellular location: Nucleus, nucleoplasm
InterPro domains:
- IPR018783: Transcription factor, enhancer of yellow 2 (family) [11-107]
- IPR038212: Transcription factor EnY2 superfamily (homologous_superfamily) [9-109]
Sequence:
MYLKMHVDVQVSKMNKDAQMRAAINQKLIETGERERLKELLRAKLIECGWKDQLKAHCKEVIKEKGLEHVTVDDLVAEITPKGRALVPDSVKKELLQRIRTFLAQHASL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065008 (regulation of biological quality), GO:0023057 (negative regulation of signaling), GO:0051051 (negative regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0046888 (negative regulation of hormone secretion), GO:0010648 (negative regulation of cell communication), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0010646 (regulation of cell communication), GO:1903828 (negative regulation of protein localization), GO:0060341 (regulation of cellular localization), GO:0051224 (negative regulation of protein transport), GO:0010817 (regulation of hormone levels), GO:0051048 (negative regulation of secretion), GO:1903531 (negative regulation of secretion by cell), GO:0046883 (regulation of hormone secretion), GO:0061179 (negative regulation of insulin secretion involved in cellular response to glucose stimulus), GO:0051223 (regulation of protein transport), GO:0090276 (regulation of peptide hormone secretion), GO:0090087 (regulation of peptide transport), GO:0070201 (regulation of establishment of protein localization), GO:0002792 (negative regulation of peptide secretion), GO:0050709 (negative regulation of protein secretion), GO:0051046 (regulation of secretion), GO:0032880 (regulation of protein localization), GO:0050708 (regulation of protein secretion), GO:1904950 (negative regulation of establishment of protein localization), GO:0090278 (negative regulation of peptide hormone secretion), GO:0046676 (negative regulation of insulin secretion), GO:0002791 (regulation of peptide secretion), GO:0061178 (regulation of insulin secretion involved in cellular response to glucose stimulus), GO:0050796 (regulation of insulin secretion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)