Protein: Hypoxia-inducible factor 3-alpha isoform X3 (A0A8M9QBW4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
- IPR000014: PAS domain (domain) [157-265]
- IPR001610: PAC motif (repeat) [229-272]
- IPR035965: PAS domain superfamily (homologous_superfamily) [168-270]
- IPR021537: Hypoxia-inducible factor, alpha subunit-like (domain) [419-446]
Sequence:
MRHSVQVTCEFRPLGIGQILRGTQVDLVPCKLPGLNDILQTKLKKELGRMYQVKSVQDELELLGQSVYEFVHPCDQEELRDILATRPGVSKKKTMEHNFFLRMKSTLTHTGRTVNIKSATWKVLHCTGHMQPFSGDDENSPSAGSFLTLLCEPIPHPSSVEFPLDSSTFLTRHNLDLTYTQCDGRVTELVGYQPDDLIGRSAFEFFHALDFDHVSRSLHILFSKGQVCTGQYRFLAKNGGFVWTETQATVLYNSRTSQPEAVVCLNFILSGVEEQDVVFSLEQTCEKPKPKVERLMVLKEEQEDSDMEESSTAKLFLQMKENPEELLQLAPHSGDAIISLTEGLELSFCCPQSPNSVPECPQDFCTPELRKLLSPIFDGPAKSHPAASPAEELPMEMEGVEKFFALKPEESLTPKGQSEAVDELDLDMLAPYISMDDDFQLTFLPQSEITPPLEMLTSNSRKRCLEDDDDDDIPVLAARWDKKQMSGPIEDQLLLSHTLLDGLSDGSDEFEPPPQKRSQLLTDRDPLLGGVQALCDTAALMRDTFLSRPPDLRRPVGETLPSLT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0008013 (beta-catenin binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0006950 (response to stress), GO:0014823 (response to activity), GO:0001666 (response to hypoxia), GO:0012501 (programmed cell death), GO:0048731 (system development), GO:0070482 (response to oxygen levels), GO:0048513 (animal organ development), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0070997 (neuron death), GO:0051402 (neuron apoptotic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048880 (sensory system development), GO:0036293 (response to decreased oxygen levels), GO:0007423 (sensory organ development), GO:0006915 (apoptotic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010468 (regulation of gene expression), GO:0001654 (eye development), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0150063 (visual system development), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0005667 (transcription regulator complex), GO:0090575 (RNA polymerase II transcription regulator complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:1990907 (beta-catenin-TCF complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)