Protein: DNA repair protein RAD4 (Q8W489)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Essential protein. May have a role in the nucleotide excision repair (NER) pathway (Probable). Promotes UV tolerance via dark repair mechanism (nucleotide excision repair)
Subcellular location: Nucleus
InterPro domains:
- IPR018328: Rad4 beta-hairpin domain 3 (domain) [666-740]
- IPR042488: Rad4, beta-hairpin domain 3 superfamily (homologous_superfamily) [672-744]
- IPR018325: Rad4/PNGase transglutaminase-like fold (domain) [382-538]
- IPR018327: Rad4 beta-hairpin domain 2 (domain) [596-659]
- IPR002931: Transglutaminase-like (domain) [188-252]
- IPR004583: DNA repair protein Rad4 (family) [5-861]
- IPR036985: Transglutaminase-like superfamily (homologous_superfamily) [124-510]
- IPR018326: Rad4 beta-hairpin domain 1 (domain) [543-594]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [141-557]
Sequence:
MKSRSESKNCRLAQASRVAVNKVLDKSSARGSRGKKKQDDNCDSAKRDKGVNGKGKQALDARLIDNVLEDRGCGNVDDDEMNDSDWEDCPIPSLDSTVDDNNVDDTRELTIEFDDDVPDAKKQKNAYRATAEDKVRAELVHKVHLLCLLARGRIVDSACNDPLIQAALLSLLPSYLTKVSNLEKVTVKDIAPLLRWVRENFSVSCSPSSEKSFRTSLAFALESRKGTAEELAALAVALLRALKLTTRFVSILDVASLKPGADRNESSGQNRAKMKHGIFRTSTLMVPKQQAISSYPKKSSSHVKNKSPFEKPQLGNPLGSDQVQDNAVNSSCEAGMSIKSDGTRRKGDVEFERQIAMALSATADNQQSSQVNNTKKVREITKISNSSSVSDQVISTAFGSKKVDSPLCWLEVYCNGENMDGKWVHVDAVNGMIDAEQNIEAAAAACKTVLRYVVAFAAGGAKDVTRRYCTKWHTISSKRVSSVWWDMVLAPLVHLESGATHDEDIALRNFNGLNPVSSRASSSSSSFGIRSALEDMELATRALTESLPTNQQAYKSHEIYAIEKWLHKNQILHPKGPVLGFCSGHPVYPRTCVQTLKTKERWLRDGLQLKANEVPSKILKRNSKFKKVKDFEDGDNNIKGGSSCMELYGKWQMEPLCLPPAVNGIVPKNERGQVDVWSEKCLPPGTVHLRFPRIFAVAKRFGIDYAPAMVGFEYRSGGATPIFEGIVVCTEFKDTILEAYAEEQEKKEEEERRRNEAQAASRWYQLLSSILTRERLKNRYANNSNDVEAKSLEVNSETVVKAKNVKAPEKQRVAKRGEKSRVRKSRNEDESHEHVFLDEEETFDEETSVKTKRCKCGFSVEVEQM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006259 (DNA metabolic process), GO:0006310 (DNA recombination), GO:0006281 (DNA repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)