Protein: Chloride anion exchanger (A0A8M9QB97)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation
Subcellular location: Membrane; Multi-pass membrane protein
InterPro domains:
- IPR002645: STAS domain (domain) [515-705]
- IPR011547: SLC26A/SulP transporter domain (domain) [72-465]
- IPR018045: Sulphate anion transporter, conserved site (conserved_site) [101-122]
- IPR036513: STAS domain superfamily (homologous_superfamily) [496-708]
- IPR001902: SLC26A/SulP transporter (family) [34-706]
Sequence:
MQPFGRHYVVVRPLFSEDSFAEQHERINRKRKTLRHHLKDYFSCDAKRAKNAALSLFPFIGWMKDYKIKEWLLGDIVSGISTGLVAVLQGLAFSLLASLPPGYGLYTAFFPAIIYFFLGTSRHLSVGAFPILSLMVGAVVTRLVPDEGPSFNITGFEGLSLEQQRVLVASSVTFLMGAFQLVMGLLQVGFIVMYLSETLVSGFTTAAAVHILVSQLRFVLGLDFPGINGPLAIIYTLVEVFSRITSTNVADLVTSIAIMALVLIVKEINDRFKSKLPVPIPIEVIMTVIACGVSYAFNFEERFDVVIVGEMVNGYESPVAPNLEVIEETAVEAFPMAIVGFAVAFSVAKVYSVKHDYTIDGNQELIAFGVSNMFGASFRSFAASTALSRTAIQESTGGKTQIAGILSAMMVLIVIVGVGFLLEPLPRSVLGALVIVNLKGMLMQFSELPFLWRNDRPDFVTWMVTFMASLFLGLDLGLAVGIGAELFTVVYRTQFPRCSVLANISGTDLYRDRKDYTSIYEPDGVKIFKIPSPIFFANIDFFRDKLVQEVGFNPMRVLKKRNKALRKIRKMLCNGELEVSDRGPVLRQPSVDTSEGSMEDLDQPIDFSDLPIQVNWNSQLPANISVPPVNIHSLILDFCAVSFIDVSALKGLKATLKEFIRIEVDVYIVSCDVYIMEKLQHCTFFDDEIKTSIFYPTLHDAMLHILETHPDHGELEKDININYEVIQRDSLTV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015106 (bicarbonate transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015293 (symporter activity), GO:0140410 (solute:bicarbonate symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015370 (solute:sodium symporter activity), GO:0008510 (sodium:bicarbonate symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0006970 (response to osmotic stress), GO:0050801 (monoatomic ion homeostasis), GO:0006810 (transport), GO:0055081 (monoatomic anion homeostasis), GO:0006811 (monoatomic ion transport), GO:0009651 (response to salt stress), GO:0015698 (inorganic anion transport), GO:0006821 (chloride transport), GO:0006820 (monoatomic anion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)