Protein: Proline dehydrogenase (A6JSI7)
Organism: Rattus norvegicus (Rat)
Function: Converts proline to delta-1-pyrroline-5-carboxylate
InterPro domains:
- IPR002872: Proline dehydrogenase domain (domain) [100-438]
- IPR015659: Proline oxidase family (family) [1-456]
- IPR029041: FAD-linked oxidoreductase-like (homologous_superfamily) [17-465]
Sequence:
MFERLMKMTFYGHFVAGEDQESIRPLIRHNKAFGVGFILDYGVEEDLSPEEAERKEMESCTSEAERDGSGANKREKQYQVHPAFGDRRDGVISARTYFYASEAKCDNYMENLLQCIEASGGASDGGFSAIKLTALGRPQFLLQFSDVLTRWRQFFHQMAAEQGQAGRPAVDTKLEVAVLQESIAKMGISSRAEIERWFTPETLGVSGTVDLLDWNSLIDSRTQLSRHLVVPNVQRAREAGVRLMIDAEQSYFQPAISRLTLEMQRRFNVDKPFIFNTFQCYLKDAYDNVTIDMELSRREGWCFGAKLVRGAYMAQERARAVEIGYEDPINPTYEATNAMYHRCLNYVLEELKHSTKAEVMVASHNEDTVSFTLCRMKELGLHPADGQVCFGQLLGMCDQISFPLGQAGFPVYKYVPYGPVMEVLPYLSRRALENSSIMKGAQRERQLLWQELCRRLRTGSLFHHPA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0016491 (oxidoreductase activity), GO:0043168 (anion binding), GO:0016645 (oxidoreductase activity, acting on the CH-NH group of donors), GO:0043177 (organic acid binding), GO:0016649 (oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor), GO:0031406 (carboxylic acid binding), GO:0016597 (amino acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0009991 (response to extracellular stimulus), GO:0044282 (small molecule catabolic process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0010941 (regulation of cell death), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0006520 (amino acid metabolic process), GO:1901575 (organic substance catabolic process), GO:0016054 (organic acid catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:0031667 (response to nutrient levels), GO:0009063 (amino acid catabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009065 (glutamine family amino acid catabolic process), GO:1901606 (alpha-amino acid catabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0006560 (proline metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)