Protein: 60 kDa heat shock protein, mitochondrial (A0A7I2V599)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [208-401]
- IPR001844: Chaperonin Cpn60/GroEL (family) [23-523]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [47-523]
- IPR027413: GroEL-like equatorial domain superfamily (homologous_superfamily) [30-524]
- IPR018370: Chaperonin Cpn60, conserved site (conserved_site) [430-441]
- IPR027410: TCP-1-like chaperonin intermediate domain superfamily (homologous_superfamily) [161-435]
Sequence:
MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKRRGLIMLARLVLNS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:1901363 (heterocyclic compound binding), GO:0008289 (lipid binding), GO:0044877 (protein-containing complex binding), GO:0097159 (organic cyclic compound binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0034185 (apolipoprotein binding), GO:0051087 (chaperone binding), GO:0051082 (unfolded protein binding), GO:0071814 (protein-lipid complex binding), GO:0002039 (p53 binding), GO:0019899 (enzyme binding), GO:0001530 (lipopolysaccharide binding), GO:0071813 (lipoprotein particle binding), GO:0044389 (ubiquitin-like protein ligase binding), GO:0003723 (RNA binding), GO:0031625 (ubiquitin protein ligase binding), GO:0003725 (double-stranded RNA binding), GO:0008035 (high-density lipoprotein particle binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0002200 (somatic diversification of immune receptors), GO:0008283 (cell population proliferation), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002253 (activation of immune response), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0001775 (cell activation), GO:0007275 (multicellular organism development), GO:0002440 (production of molecular mediator of immune response), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0002520 (immune system development), GO:0006457 (protein folding), GO:0009893 (positive regulation of metabolic process), GO:0002252 (immune effector process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0010942 (positive regulation of cell death), GO:0032103 (positive regulation of response to external stimulus), GO:0002250 (adaptive immune response), GO:0060548 (negative regulation of cell death), GO:0002366 (leukocyte activation involved in immune response), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0002694 (regulation of leukocyte activation), GO:0006725 (cellular aromatic compound metabolic process), GO:0001817 (regulation of cytokine production), GO:0046649 (lymphocyte activation), GO:0002218 (activation of innate immune response), GO:1901360 (organic cyclic compound metabolic process), GO:0070661 (leukocyte proliferation), GO:0002697 (regulation of immune effector process), GO:0035966 (response to topologically incorrect protein), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0002443 (leukocyte mediated immunity), GO:0001819 (positive regulation of cytokine production), GO:0031349 (positive regulation of defense response), GO:0044260 (cellular macromolecule metabolic process), GO:0050865 (regulation of cell activation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0002764 (immune response-regulating signaling pathway), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0002562 (somatic diversification of immune receptors via germline recombination within a single locus), GO:0045785 (positive regulation of cell adhesion), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031647 (regulation of protein stability), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0050867 (positive regulation of cell activation), GO:0002377 (immunoglobulin production), GO:0002696 (positive regulation of leukocyte activation), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0016445 (somatic diversification of immunoglobulins), GO:0002757 (immune response-activating signaling pathway), GO:0010941 (regulation of cell death), GO:0006139 (nucleobase-containing compound metabolic process), GO:0002833 (positive regulation of response to biotic stimulus), GO:0042026 (protein refolding), GO:0002263 (cell activation involved in immune response), GO:0002699 (positive regulation of immune effector process), GO:0080090 (regulation of primary metabolic process), GO:0031347 (regulation of defense response), GO:0002837 (regulation of immune response to tumor cell), GO:0045089 (positive regulation of innate immune response), GO:0002758 (innate immune response-activating signaling pathway), GO:0022409 (positive regulation of cell-cell adhesion), GO:0002703 (regulation of leukocyte mediated immunity), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:0002834 (regulation of response to tumor cell), GO:0022407 (regulation of cell-cell adhesion), GO:0043069 (negative regulation of programmed cell death), GO:0032655 (regulation of interleukin-12 production), GO:0002836 (positive regulation of response to tumor cell), GO:0032675 (regulation of interleukin-6 production), GO:0032735 (positive regulation of interleukin-12 production), GO:0002705 (positive regulation of leukocyte mediated immunity), GO:0032729 (positive regulation of type II interferon production), GO:0032479 (regulation of type I interferon production), GO:0010468 (regulation of gene expression), GO:0002449 (lymphocyte mediated immunity), GO:0016447 (somatic recombination of immunoglobulin gene segments), GO:0051251 (positive regulation of lymphocyte activation), GO:0090304 (nucleic acid metabolic process), GO:0006259 (DNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:0002208 (somatic diversification of immunoglobulins involved in immune response), GO:0010467 (gene expression), GO:0042113 (B cell activation), GO:0002819 (regulation of adaptive immune response), GO:0051249 (regulation of lymphocyte activation), GO:0046651 (lymphocyte proliferation), GO:0002381 (immunoglobulin production involved in immunoglobulin-mediated immune response), GO:0032733 (positive regulation of interleukin-10 production), GO:0045088 (regulation of innate immune response), GO:0043030 (regulation of macrophage activation), GO:0051336 (regulation of hydrolase activity), GO:0043068 (positive regulation of programmed cell death), GO:0032755 (positive regulation of interleukin-6 production), GO:0032649 (regulation of type II interferon production), GO:0010628 (positive regulation of gene expression), GO:0032943 (mononuclear cell proliferation), GO:0002839 (positive regulation of immune response to tumor cell), GO:0032481 (positive regulation of type I interferon production), GO:0043032 (positive regulation of macrophage activation), GO:0002460 (adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0051247 (positive regulation of protein metabolic process), GO:0002821 (positive regulation of adaptive immune response), GO:0042110 (T cell activation), GO:0032653 (regulation of interleukin-10 production), GO:0006986 (response to unfolded protein), GO:0050821 (protein stabilization), GO:0002285 (lymphocyte activation involved in immune response), GO:0042981 (regulation of apoptotic process), GO:0002822 (regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0002204 (somatic recombination of immunoglobulin genes involved in immune response), GO:0050863 (regulation of T cell activation), GO:0030162 (regulation of proteolysis), GO:0002221 (pattern recognition receptor signaling pathway), GO:0052547 (regulation of peptidase activity), GO:0006310 (DNA recombination), GO:0042100 (B cell proliferation), GO:0051345 (positive regulation of hydrolase activity), GO:0032727 (positive regulation of interferon-alpha production), GO:0043065 (positive regulation of apoptotic process), GO:0050870 (positive regulation of T cell activation), GO:0002824 (positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0002708 (positive regulation of lymphocyte mediated immunity), GO:0043066 (negative regulation of apoptotic process), GO:0032647 (regulation of interferon-alpha production), GO:0019724 (B cell mediated immunity), GO:0002312 (B cell activation involved in immune response), GO:0045862 (positive regulation of proteolysis), GO:0002706 (regulation of lymphocyte mediated immunity), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:0010952 (positive regulation of peptidase activity), GO:0052548 (regulation of endopeptidase activity), GO:0016064 (immunoglobulin mediated immune response), GO:0016444 (somatic cell DNA recombination), GO:0002709 (regulation of T cell mediated immunity), GO:0002224 (toll-like receptor signaling pathway), GO:0002711 (positive regulation of T cell mediated immunity), GO:0045190 (isotype switching), GO:0002755 (MyD88-dependent toll-like receptor signaling pathway), GO:0010950 (positive regulation of endopeptidase activity), GO:2000116 (regulation of cysteine-type endopeptidase activity), GO:2001056 (positive regulation of cysteine-type endopeptidase activity), GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)