lokahq/bioreason-rl huggingface dataset:
Protein: non-specific serine/threonine protein kinase (A0A8M2BII7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR000719: Protein kinase domain (domain) [20-270]
- IPR017441: Protein kinase, ATP binding site (binding_site) [26-49]
- IPR050629: STE20/SPS1-related Proline-Alanine-rich Kinase (family) [8-336]
- IPR048288: Programmed cell death protein 10, dimerisation domain (domain) [361-415]
- IPR046409: Programmed cell death protein 10, dimerisation domain superfamily (homologous_superfamily) [354-430]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [19-322]
Sequence:
MAHLRDMQNQNSRLDPEEYFTKQERIGKGSFGEVYKGINNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKGTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLEYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNTPPTLEGSYSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSYLTELIDRYRRWKSEGHGDESSSDDSDMYAVHPLDGDGDDRDHCPVWTFPTVRPSSMNKLQKGYTNTDSEAAETVKRQPKSQCLSALVSPIFRELKEKRRACGGGMGAIEELENAFNLAEESCPGISDLLVTHIMERVCRFALNGNTTPSSR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035295 (tube development), GO:0048513 (animal organ development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0007507 (heart development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Kin of IRRE like a isoform X1 (A0A8M3BAV1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single- pass type I membrane protein
InterPro domains:
Sequence:
MQGLLLLLSLALSFHRVRTARFSQEPADQSVVLGQRVVLSCVVFNYSGIVQWTKDGLALGIGEDLRAWPRYRVLRLVDVGQYNLEISAAELSDDSLYECQATEAALRSRRAKLTVLIPPDEPVIEGSPEILLTAGVPYNMSCVSRGAKPASVIEWQKDGLPIEGAVSTTEVLPDRKRVTTRSYLPIQPLDTDTGKNFTCVATNLAVPMGKRATITLNVHHPPVVTLSIEPRSVLEGERVTFTCQATANPPIMGYKWAKGGVVIQGARESVFVTKADHSFFTEPVSCQVFNAVGSTNVSILVDVHFGPILVVEPKPVTVDVDSDVTLNCKWAGNPPLTLTWTKKGSSMVLSNNNQLYLKSVSQADAGQYVCKAIVPRIGVGETEVTLTVNGPPIISSEPFQYAVRGERGEVKCYIASTPPPDKIVWAWKENVWEKEKGTLSERYTVEQSKPSAQGGAVLSTLTINNIMESDFQSTYNCTAWNSFGSGTMIISLEEMEIVPVGIIAGGTVGCSILLLLCLLALVLFLYRQRKGSRRGVTLGKPDIKVETINKESHSLEEDSGSVSTATRMVKAMYSFLPSVTLSPSSQPFKDDIDLKQELRSDTLDTRQDYELKDPTNGYYNVRASTHDEGRPASRSMHYSDYRTSSQPGGAAAVVSSSSGPPPGATAGPGTPSSLAPGSRAGCYDPRPPSRLSHNSYAQFNTFTRAGQSQQPPPGSGPQTSDFPAECSLLDSSGQLGYENYGYPSHYPTFRMGFAPPSLAPLEGGPAYEMYGVGPSVGAGGGAGTPETGLGKYGSSTRFSYTSQHSDYSHRHTQRMQTHV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0098609 (cell-cell adhesion), GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules), GO:0007156 (homophilic cell adhesion via plasma membrane adhesion molecules)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: ubiquitinyl hydrolase 1 (A0A8M3BED9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR036443: Zinc finger, RanBP2-type superfamily (homologous_superfamily) [82-109]
- IPR001876: Zinc finger, RanBP2-type (domain) [1-178]
- IPR049768: Ubiquitin thioesterase ZRANB1, ovarian tumor domain (domain) [386-572]
- IPR041294: Ankyrin ubiquitin-binding domain (domain) [227-322]
- IPR051346: OTU Domain-Containing Deubiquitinase (family) [66-625]
- IPR003323: OTU domain (domain) [413-573]
Sequence:
MTDLCVKWSCEYCTFENWPSAIKCTMCRAQXPSGTIITEESFPSSTGPRAGHPWEPERSDSLLICPDSSARPRVRPAESSEPSGKWSCQVCTYLNWPRAVRCTQCRSLRQRVSSPTDTPQTSSTLRRPASAPAVDPCEEYNDRNRLNTRTQCWTCLACTYENALKSFRCVVCDHPRPNDTFLPPEPEEPSPGRGVCGAAQKHSPPSSRREAELQIELAAGAHSRPEEMDFKKIKQIKNRMRKTDWLFLNACAGVVEGDLSAVEAYKSSGGDIARQLNADEVRLLNRPSAFDSGFTLVHLAIRFQRQDMLAILLTEVSQRAVKCIPAMVCPELTEQIRREISSSLHQRKGDFNCYFLTDLVTFTLPADIEDLPPAVQEKLFDEVLDRDVQKELEEESAVINWSLELGSRLDSRLYALWNRTAGDCLLDSVLQATWGIYDKDSVLRKTLHDSLHDCSHWFYTRWKEWESWYSQSFGLHFSLREEQWQEDWTFILNLASQPGASLEQTHIFVLAHILRRPIIVYGVKYYKSFRGDTLGYTRFQGVYLPLLWEQSFCWKSPIALGYTRGHFSALVGMESDGYDNRGAGANLNTDDDVTVTFLPLVDSERKLLQIHFLSAQEMGSEEQQERLLRHWLDCCVTDGGMLVALQKSSRRRHHPLITQMLEKWLDGYRQMHPCPTLSDGEEEEDDEDE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:0061578 (K63-linked deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0021551 (central nervous system morphogenesis), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: O-acyltransferase (A0A8M9NZ90)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane; Multi- pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR014371: Sterol O-acyltransferase, ACAT/DAG/ARE types (family) [9-401]
- IPR004299: Membrane bound O-acyl transferase, MBOAT (family) [74-394]
- IPR027251: Diacylglycerol O-acyltransferase 1 (family) [9-401]
Sequence:
MRPLRQNEVLSNARLFLENLLRYGILVDPIQVVSLFLKDPYSWPAACLVIVCNAFILVALYTERKLAMGSISEKVGLLIYIFNLTIILCFPMVVVLKLPSITPVGGAFALGIYTILFLKLYSYKDVNKWCRERTQAKARSLSRSLSCPSPPSTSSSMQSYVSYPGNLSLRDIYYFVFAPTLCYELNFPRSESIRMGFLLRRLFEMLLLTQLLVGLTQQWMVPIIRSSMKPLQEMDYTRMTERLLRLAVPNHLLWLIFFYSFFHSSMNFMAELLRFGDREFYRDWWNSETITYFWQNWNIPVHKWCLRHFYKPLLRRGAGKLLSQSAVFFASAFFHEYLVSVPLRMFRLWAFMGMMAQIPLAWLVSRFLRGNYGNAAVWLSLIIGQPIAVLMYVHDYYVTNHQDDLTINEDL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0008374 (O-acyltransferase activity), GO:0016411 (acylglycerol O-acyltransferase activity), GO:0004144 (diacylglycerol O-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0009620 (response to fungus), GO:0043207 (response to external biotic stimulus), GO:0001878 (response to yeast)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Bardet-Biedl syndrome 12 protein isoform X2 (A0A8M9QKQ4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [447-598]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [30-743]
- IPR042984: Chaperonin-containing T-complex member BBS12 (family) [11-762]
- IPR027413: GroEL-like equatorial domain superfamily (homologous_superfamily) [5-746]
- IPR027410: TCP-1-like chaperonin intermediate domain superfamily (homologous_superfamily) [391-634]
Sequence:
MDPSCKQCSFAMKRRHIGLQQLQAITSTAHAFLGPNKRLKFIQDEDAGDAVLIGSCPRLLEHLELDGSVGQLLHETVLAQKKLFHSGTNTLMFLAGAWSRVALECLNRGISVSDIKSAMRGGLQECLDACTQLAVSVEEFKKSDVRSNDQCIDMMVKHSRYINARTKNTQSDDNVQDFRKLSIKSDDQCMDMTHKHSRYANTQTEHAQSDDNVQDFKGSGIKSNDQCMDMTLKHSRYINTKTEHAQSNVNMQDFRKLDDKSDDQCKHMTLKHSRHFNARTKNTQSDVNVQDLKGSDIKSIDQCMDMTLKHSTHFNAQTEHNMQDFRKLDDKSDDQCMYMTLKHSRHFNAQTEHTQSEVTMQDFTKSDIKLDNQSMHMTLKHSRHFNAQTEHTHHDVTVIAQAVSHGCSSMHLLLKAYELQNRAHLDIHNLATCCIPGVSEDHACVLRGYVTLLSVQQTTQVQRLQGRPLNIALINGDLSEKYRHVGFNRPGNIKHITDLFITEESWIENAYKLLHDSSIDVVFVSGVVDVDLKQRCKDVLILEGVKSSVLKHFSTCTGAVPVSYICQLDERRVGRGLRLRKESISGRSDIVSITTDCSVLVTAVICSSVSAKLQMLEDEFWSCAHRLQHALTDGKLLHGAGVTELICIRRLRQYTQLHPDSPHDSAVLELMSEAWMDFISTVMLNSGSVANRTEAWTSITHQMRRHTDIGVTDGLGVYDNVTVKCEAWRRALDLVFLVLQSDTEIITGVSQGENTYNQLMFL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0007369 (gastrulation), GO:0060027 (convergent extension involved in gastrulation), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0060026 (convergent extension)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Aquaporin-7 isoform X2 (A0A8M2B7X7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
Sequence:
MEDGSIQGRMAPNVGSMLKIKNEYIRVALAESLCTFIMMVFGLGTVAQVVTGEGYFGEYLSINIGFGLAVAMGVHVGGKVSGAHMNAAVSFTMCVFGRLRWKMLPLYVFAQFLGSFLAAGTIFSLYYAFVLLFIDAINHFCGGNLTVSGPKATAGIFATYPAPYISVYTGFFDQVAGTGLLLLCLMALSDQRNQPLVSGGEAVGVGLLVMLIGVSMGSNSGYAINPTRDLGPRLFTLMAGWGTEVFRAGNCWWWVPLVAPFIGGVLGALIYKALVELHHPDLKSTITRPAVDPECIPLDKCKNGRIEIPV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0042887 (amide transmembrane transporter activity), GO:1901618 (organic hydroxy compound transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015144 (carbohydrate transmembrane transporter activity), GO:0005372 (water transmembrane transporter activity), GO:0015204 (urea transmembrane transporter activity), GO:0015166 (polyol transmembrane transporter activity), GO:0015168 (glycerol transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0015791 (polyol transmembrane transport), GO:0034219 (carbohydrate transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0015793 (glycerol transmembrane transport), GO:0015850 (organic hydroxy compound transport), GO:0008643 (carbohydrate transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Transcription factor SOX-5 isoform X5 (A0A8M9Q0P1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
- IPR051356: SOX/SOX-like transcription factors (family) [14-733]
- IPR009071: High mobility group box domain (domain) [533-603]
- IPR036910: High mobility group box domain superfamily (homologous_superfamily) [528-611]
Sequence:
MLTEPELPQEFNRMSSKRPASPYGGTDGEVVMATSRQRLEDEEVDGHAVIHLPLSSYCSKVSPRSPRLLDSPPTLHANMDQDGSKGLALSPYAQHNSSTSPSKQQQEDSSMRPGSEPGSASALGTPERRKGSLADVVDTLKQRKMEELIKNEPEEAPSIERLLSKDWKDKLLAMGSGNFGEIKGTPDSLAEKERQLMGMITQLSSLREQLLAAHEEQKKLAASQIEKQRQQMELAKQQQDQIARQQQQLLQQQHKINLLQQQIQQVQGQLPPLMIPVFPPDQRTLAAAAAQQGFLLPPGFNYKPGCSEPYPLQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGAKHSTVPQANLATGTLSPTSGQSEKNRSTPPPKPKVPALKLGPGSLKHSAPSSIGGPPSRLSSIDLLSSITSAGYLNDHEAVTKAFQEARKMKEQLKREEQVLDAKVAAVNSLSLNNGRSEKVRFMEKAALESLSQQLKQSEESKFTHAMMDFGISGDSDGSPSVSDSRIFREARGRGSSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYFTVGQQAQLPLSSAGVVYPGALSMAGMPSPQMPSEHSSMSSSPEPVPPTSQASYFKEVEPRVKEELRMDDGNGDAYDDFDYEDDDGDYGSDSENHITQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0048869 (cellular developmental process), GO:0048066 (developmental pigmentation), GO:0050931 (pigment cell differentiation), GO:0030154 (cell differentiation), GO:0030318 (melanocyte differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: RNA binding protein fox-1 homolog (A0A8M9Q953)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: RNA-binding protein that regulates alternative splicing events
Subcellular location: Nucleus
InterPro domains:
Sequence:
MGITGLGNQEAPAPPEAMAQPYAPAQYPPPPPQNGLPGEYTHPGQDYTGPSPVPEHAAALTIYTPTQTHSEPPGTDSSTPSLTGTSSLTQADDVVQTDGSQQLQLQPSDSSEKQQPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFETSADADRAREKLNGTIVEGRKIEVNNATARVMTNKKVANPYTNGWKLNPVVGAVYGPEFYAVTGFPYPTTGATVAYRGAHLRGRGRAVYNTFRAAPPPPPIPAYGAVVYQDGFYGAEIYGGYAAYRYAQPAAAAAAAYSDSYGRVYATADPYHHTIGPAATYSVGTMASLYRGGYSRFTPY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010467 (gene expression), GO:0010468 (regulation of gene expression), GO:0016070 (RNA metabolic process), GO:0043484 (regulation of RNA splicing), GO:1903311 (regulation of mRNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0048024 (regulation of mRNA splicing, via spliceosome), GO:0006397 (mRNA processing), GO:0050684 (regulation of mRNA processing), GO:0016071 (mRNA metabolic process), GO:0048024 (regulation of mRNA splicing, via spliceosome), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000381 (regulation of alternative mRNA splicing, via spliceosome), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Voltage-gated potassium channel subunit beta-1 (A0A8M9PWJ3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side
InterPro domains:
- IPR023210: NADP-dependent oxidoreductase domain (domain) [125-442]
- IPR005400: Potassium channel, voltage-dependent, beta subunit, KCNAB1 (family) [344-441]
- IPR005983: Potassium channel, voltage-dependent, beta subunit, KCNAB (family) [110-443]
- IPR036812: NAD(P)-dependent oxidoreductase domain superfamily (homologous_superfamily) [109-449]
- IPR005399: Potassium channel, voltage-dependent, beta subunit, KCNAB-related (family) [73-455]
Sequence:
MSSVVQNPYVTRPPRNRVPKNGPPGNSVRRSSSISSSKLLSLSFSESMRSDIDRYLSDQGLYPLRQGGGEMGEIRSLREVRAAAQLKNLEDFLRSNGVSLQESISFQTGMRYRNLGKSGLRVSCLGLGTWVTFGGQITDEIAEQLMTLAYENGINLFDTAEVYAAGKAEMVLGSIIKKKGWRRSSLVITTKIYWGGKAETERGLSRKHIIEGLRASLERLQLEYVDVVFANRPDPNTPMEGDPFNTSKSRTFIIEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPVCEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIISGKYDSGVPPCSRASLKGYQWMKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSCVLLGASSTDQLMENIGAIQVLPKLSSSIIHEVDSILGNKPYSKKDYRS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0016247 (channel regulator activity), GO:0005515 (protein binding), GO:0099106 (ion channel regulator activity), GO:0015459 (potassium channel regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0098900 (regulation of action potential), GO:0051239 (regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0010646 (regulation of cell communication), GO:0042391 (regulation of membrane potential), GO:0044057 (regulation of system process), GO:0051969 (regulation of transmission of nerve impulse), GO:0031644 (regulation of nervous system process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0008076 (voltage-gated potassium channel complex), GO:0034703 (cation channel complex), GO:0034705 (potassium channel complex)
Protein: Insulin receptor substrate 2 isoform X1 (A0A8M9PD89)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR039011: Insulin receptor substrate (family) [1-1026]
- IPR002404: IRS-type PTB domain (domain) [156-264]
- IPR001849: Pleckstrin homology domain (domain) [22-125]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [15-261]
Sequence:
MASPPLKGGPSLSNSNNIHSNNIRKHGYLKKQKHGHRRYFVLKDTSDGLPARLEYHENEKKWKNKSAPKRVIFLDSCLSINKRADAKHRYLIALYTKDEYFAVAAENEQEQESWYGDLADLLSKGKVCDSTVSNSASSLVGFDEGNYGMITPVNAAYKEVWQVNLKAKGLGQSRNITGVFRLCLTSRTISFVKLNSEVASVTLQLMNIRRCGHSDSFFFIEVGRSASTGPGELWMQADDSVVAQNIHETILEAMKAMKELSEFRPRSKSQSSGSNPISVPTRRNLNNLPPSQTGLVRRSRTDSTAATSPVTKFSSCRIRTASEGEGTMIRPVSVSVSENGSPMTVGRHHMSRSNTVSVGCRTSEPSLLNHSRSMSMTMYHSPPSVVSPLSLSSISMNGSISNKAHRPSSCSGSVSGSPNDFGFLTCEDYSSSPGDVRYNLANRSDTPSSLSSTPPLRETSELHSYMVMDRPSNFSQNKTSRDMLDVETYRKRTYSLTTPRQQMAHSQLSSASLDEYMLMRAANSHSGRSTNSASPKLSYPEDYGDIEIGSNCNVGDDGYMPMTPGMAPQSAKNDHYMPMSPMSVSAPKQIINPRSHPQSPGSGCTANSPSSGSLEDSGYMKMWSGSKFSLESSDGKAANGEYVNMSPVDTSISPTPPEYFMGPCEPTQRPSPTQSIRFNKQQVPKRVDDNQYVFMSPQNQNQTEEANSVSSLPPLYRPDVMAQRSKVNRPNRLSLDALRMLPRMTEHPLPCEPKSPGEYINIDFAAATQYSSQSMVTVENQASLSSLRQGSPLSDYMNLNQSSHSSKLCEMSSPLDGLPELAECPPDDGTCFLNEQRNLPCPSVSGKGNYTEMSFNSGSLENQKSASVSPTSRVQRLNLGNQGVSKGIGAFLLAASSVDPNGGAKVIRADPQGRRRHSSETFSSTTTVAPVFPSFAHNVKRHSSASVENISVRSSEGSDEEYESPMCQEMSAGYQNGLNYIALNLMEKQETGNCENLVGFKTGGCCKAGINGLHTTPYVCLGFKETATTVQVLLKTIVSICMCGRWLNRCGAVCVCARVHLPLCSPQIEQEAEVTPNAKGKWKLNH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0043548 (phosphatidylinositol 3-kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009628 (response to abiotic stimulus), GO:0070482 (response to oxygen levels), GO:0001666 (response to hypoxia), GO:0036293 (response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)