Protein: Anion exchange protein 4 (Q9GKY1)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Electroneutral Cl(-)/HCO3(-) antiporter that favors chloride ion entry and efflux of hydrogencarbonate and sodium ion across the basolateral membrane and may participat in salivary secretion . Also mediates Cl(-)/HCO3(-) exchange activity in the presence of K(+) as well as Cs(+), Li(+), and Rb(+). Does not contribute to Cl(-)/HCO3(-) exchanger in the apical membrane of the upper villous epithelium (By similarity)
Subcellular location: Lateral cell membrane ; Multi-pass membrane protein . Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane ; Multi-pass membrane protein . Note=Localized at the apical and lateral cell membrane of intercalated cells
InterPro domains:
- IPR016152: Phosphotransferase/anion transporter (homologous_superfamily) [47-326]
- IPR003020: Bicarbonate transporter, eukaryotic (family) [52-919]
- IPR011531: Bicarbonate transporter-like, transmembrane domain (domain) [356-914]
- IPR003024: Sodium bicarbonate cotransporter (family) [283-492]
- IPR013769: Band 3 cytoplasmic domain (domain) [52-301]
Sequence:
MKLPGQEELEAACACENVPVGQLDSGPSSGPCPDDPSDTGSRELGPPEDPPLFLQLNELLGWPQTLEWREMGRWVLFEEKLEVDAGRWSAPHVPTLALPSLQNLRSLLAEGLVLLDCPAQNLLELVEQVTRVESLSPELRGQLQALLLQRPQHHTQTTGSRPCWGPAQSRKAAHNKEAPMQQQCQSPLRQKLPPGAEAGAVLAGELGFLAQPLAAFVRLRDPVWLGPLTEVPLPSRFFCLLLGPPMLGKGYHELGRAAAVLLSDPHFQWSVRRASNLHDLLTALDAFLEEVTVLPPGRWDPTARIPPPRCLPSRHKRPPLHLQKVKGLSVPHRTQAEDRHRNGPLAPSPELQRTGRLFGGLVQDVRRKASWYPSDFSDALHPQCVSAVLYIYLATVTNAITFGGLLGDATDGAQGVLESLLGTAVAGAAFCLMAGQPLTVLSSTGPVLVFERLLFAFCRDYSLDYLPFRLWVGIWVAVFCLALVATEASVLVRYFTRFTEEGFCALISLIFIYDAVGKMLNLAHAYPIQRPGSLAYGCLCQFPGPGGNESQWTRPRPQSRDDLLSVDLGLVNASLLPPHECVQQGGYPRGPGCHTVPDIAFFSLLLFLTSFLFAIALKHMKTSRFFPSVVRKVLSDFSSILAILLGCGLDALLGLAMPKLMVPREFKPTLPGRGWLVPPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRVEYRLRKGAGFHLDLFCVALLMLLTSVLGLPWYVSATVLSLAHMDSLRRESRACAPGEPHSFLGIREQRLTGLAVFTLTGVSIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFMKRVQLMLMPAKHQPDLLLLRHVPLSRVHLFTAIQLACLGLLWIIKSTPAAIIFPLMLLGLVGVRKALEWVFSPQELLWLDELMPEEERNVPEKGLEPGHSFSGSDSEDSELMYQPKAPEINISVN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015106 (bicarbonate transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015293 (symporter activity), GO:0140410 (solute:bicarbonate symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015370 (solute:sodium symporter activity), GO:0008510 (sodium:bicarbonate symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0071702 (organic substance transport), GO:0006812 (monoatomic cation transport), GO:0006816 (calcium ion transport), GO:0070509 (calcium ion import), GO:0030001 (metal ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)