Protein: Transitional endoplasmic reticulum ATPase (A0A7P0T8A3)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum. Nucleus
InterPro domains:
- IPR003593: AAA+ ATPase domain (domain) [192-604]
- IPR005938: AAA ATPase, CDC48 family (family) [2-717]
- IPR041569: AAA ATPase, AAA+ lid domain (domain) [348-663]
- IPR003959: ATPase, AAA-type, core (domain) [196-602]
- IPR050168: AAA ATPase domain-containing protein (family) [1-718]
- IPR004201: CDC48, domain 2 (domain) [80-146]
- IPR029067: CDC48 domain 2-like superfamily (homologous_superfamily) [62-153]
- IPR009010: Aspartate decarboxylase-like domain superfamily (homologous_superfamily) [1-60]
- IPR003338: CDC48, N-terminal subdomain (domain) [1-63]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [155-715]
- IPR003960: ATPase, AAA-type, conserved site (conserved_site) [296-590]
Sequence:
MDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGGAGPSQGSGGGTGGSVYTEDNDDDLYG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016887 (ATP hydrolysis activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0044877 (protein-containing complex binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0042802 (identical protein binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0043531 (ADP binding), GO:0032555 (purine ribonucleotide binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0017076 (purine nucleotide binding), GO:0016462 (pyrophosphatase activity), GO:0005524 (ATP binding), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0048519 (negative regulation of biological process), GO:0016032 (viral process), GO:0051641 (cellular localization), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0019079 (viral genome replication), GO:0071840 (cellular component organization or biogenesis), GO:0065008 (regulation of biological quality), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0061919 (process utilizing autophagic mechanism), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0019058 (viral life cycle), GO:0044281 (small molecule metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0009266 (response to temperature stimulus), GO:0009968 (negative regulation of signal transduction), GO:0044248 (cellular catabolic process), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0044089 (positive regulation of cellular component biogenesis), GO:0045184 (establishment of protein localization), GO:0006914 (autophagy), GO:0044087 (regulation of cellular component biogenesis), GO:0006793 (phosphorus metabolic process), GO:0046685 (response to arsenic-containing substance), GO:0009408 (response to heat), GO:0009894 (regulation of catabolic process), GO:0010035 (response to inorganic substance), GO:1901360 (organic cyclic compound metabolic process), GO:0030968 (endoplasmic reticulum unfolded protein response), GO:0046907 (intracellular transport), GO:0042391 (regulation of membrane potential), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0035966 (response to topologically incorrect protein), GO:0016043 (cellular component organization), GO:1901575 (organic substance catabolic process), GO:0051128 (regulation of cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0010648 (negative regulation of cell communication), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0060341 (regulation of cellular localization), GO:0019637 (organophosphate metabolic process), GO:0019538 (protein metabolic process), GO:0051649 (establishment of localization in cell), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0051130 (positive regulation of cellular component organization), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0062013 (positive regulation of small molecule metabolic process), GO:0010941 (regulation of cell death), GO:0006139 (nucleobase-containing compound metabolic process), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0043254 (regulation of protein-containing complex assembly), GO:0071705 (nitrogen compound transport), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:0051788 (response to misfolded protein), GO:0019439 (aromatic compound catabolic process), GO:0030163 (protein catabolic process), GO:0046700 (heterocycle catabolic process), GO:0071702 (organic substance transport), GO:0072521 (purine-containing compound metabolic process), GO:0051881 (regulation of mitochondrial membrane potential), GO:1903513 (endoplasmic reticulum to cytosol transport), GO:0006140 (regulation of nucleotide metabolic process), GO:0009057 (macromolecule catabolic process), GO:0006886 (intracellular protein transport), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0015031 (protein transport), GO:0018130 (heterocycle biosynthetic process), GO:0034605 (cellular response to heat), GO:0045981 (positive regulation of nucleotide metabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0006259 (DNA metabolic process), GO:0043933 (protein-containing complex organization), GO:0043085 (positive regulation of catalytic activity), GO:1901701 (cellular response to oxygen-containing compound), GO:0022411 (cellular component disassembly), GO:0045879 (negative regulation of smoothened signaling pathway), GO:0034655 (nucleobase-containing compound catabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0010562 (positive regulation of phosphorus metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0042176 (regulation of protein catabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0071310 (cellular response to organic substance), GO:0051336 (regulation of hydrolase activity), GO:0019438 (aromatic compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0030111 (regulation of Wnt signaling pathway), GO:0032880 (regulation of protein localization), GO:0030177 (positive regulation of Wnt signaling pathway), GO:0042726 (flavin-containing compound metabolic process), GO:0008589 (regulation of smoothened signaling pathway), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0036211 (protein modification process), GO:0016236 (macroautophagy), GO:0034976 (response to endoplasmic reticulum stress), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0043467 (regulation of generation of precursor metabolites and energy), GO:0035967 (cellular response to topologically incorrect protein), GO:0010243 (response to organonitrogen compound), GO:0071243 (cellular response to arsenic-containing substance), GO:0016197 (endosomal transport), GO:0044265 (cellular macromolecule catabolic process), GO:0045838 (positive regulation of membrane potential), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0045732 (positive regulation of protein catabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006986 (response to unfolded protein), GO:0016192 (vesicle-mediated transport), GO:0031331 (positive regulation of cellular catabolic process), GO:0008104 (protein localization), GO:1901857 (positive regulation of cellular respiration), GO:0007034 (vacuolar transport), GO:0031329 (regulation of cellular catabolic process), GO:0006996 (organelle organization), GO:0046434 (organophosphate catabolic process), GO:0072524 (pyridine-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0031334 (positive regulation of protein-containing complex assembly), GO:1900542 (regulation of purine nucleotide metabolic process), GO:0042981 (regulation of apoptotic process), GO:0030810 (positive regulation of nucleotide biosynthetic process), GO:0009117 (nucleotide metabolic process), GO:0030162 (regulation of proteolysis), GO:0071218 (cellular response to misfolded protein), GO:1905634 (regulation of protein localization to chromatin), GO:0052547 (regulation of peptidase activity), GO:0045937 (positive regulation of phosphate metabolic process), GO:0030970 (retrograde protein transport, ER to cytosol), GO:0034620 (cellular response to unfolded protein), GO:0071985 (multivesicular body sorting pathway), GO:0006281 (DNA repair), GO:0008333 (endosome to lysosome transport), GO:1901292 (nucleoside phosphate catabolic process), GO:1900544 (positive regulation of purine nucleotide metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)