Protein: Voltage-gated hydrogen channel 1 (A6J1B3)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR031844: Voltage-gated hydrogen channel 1, C-terminal membrane-localisation domain (domain) [219-265]
- IPR005821: Ion transport domain (domain) [96-209]
- IPR031846: Voltage-gated hydrogen channel 1 (family) [21-266]
- IPR027359: Voltage-dependent channel domain superfamily (homologous_superfamily) [86-211]
Sequence:
MTSHDQKAVTRRTKVAPTKRMSRFLKHFTVVGDDYHTWNVNYKKWENEEDEEEPAPTSAEGEGSAVGPDAEAGSASTPRPSLDFRSRLRKLFSSHRFQVIIICLVVLDALLVLAELLLDLRIIEPDLSVKVFHYLSLAILAFFVLEISLKVFVFRLEFFHHKFEILDAIVVVVSFVLDLILLFKNHHFEALGLLILLRLWRVARIINGIIISVKTRSERQILRLKQINLQLATKIQHLEFSCSEKEQEIERLSKLLRQNGLLEDVNVN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0042802 (identical protein binding), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0015078 (proton transmembrane transporter activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0015252 (proton channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0009893 (positive regulation of metabolic process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0019222 (regulation of metabolic process), GO:0006885 (regulation of pH), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0031323 (regulation of cellular metabolic process), GO:0030641 (regulation of cellular pH), GO:0031325 (positive regulation of cellular metabolic process), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:2000379 (positive regulation of reactive oxygen species metabolic process), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:0051453 (regulation of intracellular pH), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0032930 (positive regulation of superoxide anion generation), GO:0090322 (regulation of superoxide metabolic process), GO:0032928 (regulation of superoxide anion generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045177 (apical part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane)