Protein: Signal recognition particle 54 kDa protein (A0A7P0PJI2)
Organism: Homo sapiens (Human)
Function: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development
Subcellular location: Cytoplasm. Nucleus speckle. Endoplasmic reticulum
InterPro domains:
- IPR003593: AAA+ ATPase domain (domain) [41-218]
- IPR036891: Signal recognition particle, SRP54 subunit, M-domain superfamily (homologous_superfamily) [239-378]
- IPR000897: Signal recognition particle, SRP54 subunit, GTPase domain (domain) [42-237]
- IPR004125: Signal recognition particle, SRP54 subunit, M-domain (domain) [267-372]
- IPR006325: Signal recognition particle, SRP54 subunit, eukaryotic (family) [27-371]
- IPR022941: Signal recognition particle, SRP54 subunit (family) [27-435]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [36-239]
Sequence:
MVLADLGRKITSALRSLSNATIINEELVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEGLIDKVNELKLDDNEALIEKLKHGQFTLRDMYEQFQNIMKMGPFSQILGMIPGFGTDFMSKGNEQESMARLKKLMTIMDSMNDQELDSTDGAKVFSKQPGRIQRVARGSGVSTRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNVSQSQMAKLNQQMAKMMDPRVLHHMGGMAGLQSMMRQFQQGAAGNMKGMMGFNNM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0060998 (regulation of dendritic spine development), GO:0050773 (regulation of dendrite development), GO:0045597 (positive regulation of cell differentiation), GO:2000026 (regulation of multicellular organismal development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0061001 (regulation of dendritic spine morphogenesis), GO:0022604 (regulation of cell morphogenesis), GO:0061003 (positive regulation of dendritic spine morphogenesis), GO:0050807 (regulation of synapse organization), GO:0031344 (regulation of cell projection organization), GO:0031346 (positive regulation of cell projection organization), GO:0010256 (endomembrane system organization), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0048814 (regulation of dendrite morphogenesis), GO:0050769 (positive regulation of neurogenesis), GO:0051960 (regulation of nervous system development), GO:0006996 (organelle organization), GO:0010770 (positive regulation of cell morphogenesis involved in differentiation), GO:0010769 (regulation of cell morphogenesis involved in differentiation), GO:0007030 (Golgi organization), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0050767 (regulation of neurogenesis), GO:0050775 (positive regulation of dendrite morphogenesis), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)