lokahq/bioreason-rl huggingface dataset:
Protein: Phospholipid scramblase (A0A509AGE2)
Organism: Plasmodium berghei (strain Anka)
Function: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry (By similarity). Preferentially, mediates calcium-dependent phosphatidylethanolamine externalization (By similarity). During the liver stage, plays a role in the interaction with, and thus invasion of, host hepatocytes, possibly by interacting with host carbamoyl-phosphate synthase CPS1 . Dispensable for host erythrocyte invasion and asexual parasite development (By similarity)
Subcellular location: Cell membrane. Note=In sporozoites, localizes to the cell membrane
InterPro domains:
- IPR005552: Scramblase (family) [134-430]
Sequence:
MRNQLVNASLKKTIYASNMINKDQNQNTNQQNMRHPNMNNPNVNNPNMNYPNVNNPNMNNQNMNNSNMNNPNVNNPNVNNPNVNNPNVNNPNVNNPNVNNPNVNNPNVNNPNMNNPNVNNPNVNNPNMNNPNMNNPNMNNPNVNYPNMNIPNMNYPNMNNPNVNYPNMNNPNMNYPNMNFQQYPYIIPPPQQQMAMFFNDWRTVLAPLKGCRIKQQFDDREFLADYVMGMKFDFNNKYLILDAGNELLKFTAIENSEFFSRNCLPKMCIPINMKILSYGKELVKPDIMVEKDCSFTICCLNRPIIKMYDFSNNNNKKLIGTIRPPFSCCSFKFDLFDASNKKIIYMDDTCCQMSILCPCPFGPFKFSNYYLRDAKTHERIAHLRKEVPFLKFVKRDIDNYTLNFEDVQNPEWKMMLLAFSLFLDYIYYDAK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Osmotin-like protein PR-5x (Q8LPU1)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Antifungal protein (By similarity). May bind to beta-glucans and have beta-1,3-D-glucanase activity (By similarity)
Subcellular location: Secreted. Vacuole . Note=Secreted into the xylem sap after infection with Fusarium oxysporum f. sp. lycopersici
InterPro domains:
- IPR037176: Osmotin/thaumatin-like superfamily (homologous_superfamily) [25-230]
- IPR001938: Thaumatin family (family) [12-230]
- IPR017949: Thaumatin, conserved site (conserved_site) [82-97]
Sequence:
MGYLTSSFIFFFLALVTYTYAATIEVRNNCPYTVWAASTPIGGGRRLDRGQTWVINAPRGTKMARIWGRTNCNFNGAGRGSCQTGDCGGVLHCTGWGKPPNTLAEYALDQFSNLDFWDISLVDGFNIPMTFAPTNPSGGKCHAIHCTANINGECPSPLRVPGGCNNPCTTFGGQQYCCTQGPCGPTKFSRFFKQRCPNAYSYPQDDPTSLFTCPSGSTNYRVVFCP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009620 (response to fungus), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0050832 (defense response to fungus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Pre-mRNA-processing factor 17 (O43071)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions in the second step of pre-mRNA splicing. Involved in splicing intron which are longer than 200 nucleotides
Subcellular location: Nucleus
InterPro domains:
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [241-558]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [226-558]
- IPR019775: WD40 repeat, conserved site (conserved_site) [282-296]
- IPR001680: WD40 repeat (repeat) [255-558]
- IPR032847: Pre-mRNA-processing factor 17 (family) [3-558]
- IPR020472: PAC1/LIS1-like, WD-40 repeat (repeat) [282-425]
Sequence:
MLVANYSSDSEEQENSQSPNIQPLLHTENLAPAVVDNVKDDLIVSKGGNSRELARNVPVNEMVQPALGPANPFVTKEQDSIKNSITGYAEREYVPNFVFNQEYYANTHAIYGKRNFDDNEATTSTDLKRKSQKIKERREDPGDPSILEGDGAYKGPWAGYGSEQSSSPLEYSEYEEVESLDVKSEKDTESNNLGQNELLKEQLATPEVETHRSKEETILHKDRLFDYQNRSYMHVPNDVGINLSEEPGEQTCYIPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIAMHSMPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0045292 (mRNA cis splicing, via spliceosome), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000974 (Prp19 complex), GO:0140513 (nuclear protein-containing complex), GO:0005681 (spliceosomal complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0071014 (post-mRNA release spliceosomal complex), GO:0005634 (nucleus)
Protein: Probable DNA double-strand break repair Rad50 ATPase (Q9X1X1)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
Function: Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity)
InterPro domains:
- IPR013134: RAD50, zinc hook (domain) [389-488]
- IPR041685: Endonuclease GajA/Old nuclease/RecF-like, AAA domain (domain) [4-342]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-850]
- IPR029012: Helix hairpin bin domain superfamily (homologous_superfamily) [665-716]
Sequence:
MRPERLTVRNFLGLKNVDIEFQSGITVVEGPNGAGKSSLFEAISFALFGNGIRYPNSYDYVNRNAVDGTARLVFQFERGGKRYEIIREINALQRKHNAKLSEILENGKKAAIAAKPTSVKQEVEKILGIEHRTFIRTVFLPQGEIDKLLISPPSEITEIISDVFQSKETLEKLEKLLKEKMKKLENEISSLQALYTAIWKYLEENDLEVLKSELKTVSEKKKELLKKREELQKEEEQLKRLLEKYRELVKKKERLRVLSLRRNELQKEVIYEQKVKKAKELEPLFREIYLRQREFERFSQELNSREKRYKELESEKEAISKEIPVHRERLSKLEEIGEKIKEELDLLEKVLKASRPLLEQRIRLKENLTRLEEEFRRLVGEKEKREKELLSIEKTENETKNELEKLLDELSILKKDHMKWLAYQIASSLNEGDTCPVCGGVFHGKVEAVEFNIDEFEKLDQKRSELENTLNVLKERKKSLSSLIEDLLMKIEEGKKNLKSIRNQIEKIEEELHRLGYSEDLEEKLDEKRKKLRKIEEERHSISQKITAADVQISQIENQLKEIKGEIEAKRETLKEQREEMDQLKSDFFDRLRKIGIGFEEFRILVKEEVKDAEKELGVVETEIRLLEESLKELESENVRDVSEDYEKVRNQLEALSQEISDLERKEGRLNHLIEETLRRERELKSLEKKLKEMSDEYNNLDLLRKYLFDKSNFSRYFTGRVLEAVLKRTKAYLDILTNGRFDIDFDDEKGGFIIKDWGIERPARGLSGGERALISISLAMSLAEVASGRLDAFFIDEGFSSLDTENKEKIASVLKELERLNKVIVFITHDREFSEAFDRKLRITGGVVVNE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006281 (DNA repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)
Protein: Receptor-recognizing protein gp38 (Q9G0B4)
Organism: Escherichia phage AR1 (Bacteriophage AR1)
Function: Receptor binding protein (RBP) that is at the tip of the long tail fibers and serves as the phage recognition site for the attachment host receptor OmpC
Subcellular location: Virion. Note=Forms the distal tip of the long tail fiber
InterPro domains:
- IPR048291: Phage tail fibre adhesin Gp38, N-terminal domain (domain) [1-40]
- IPR007932: Receptor-recognising protein Gp38 (domain) [45-259]
Sequence:
MAVTGPWVGSSAVVNTGQNWMVGAAQRLRMGAPFWMSNMIGRSVEVIHTLGADHNFNGQWFRDRCFEAGSAPIVFNITGDLVSYSRDVPLFFMYGDTPNEYVQLNIHGVTMYGRGGNGWAACAIGASDGGVCIQNDIGGRLRINNGGAIAGGGGGGGGYSQANNWAGKYVCGGGGGRPFGLGGNNGARWPGGNASLTSPGAGGNTGTRYYAGGGGEVGQPGQYANPGASYSTPPTSPGAAVAGSAPTWQNVGAIYGPRV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0019058 (viral life cycle), GO:0051701 (biological process involved in interaction with host), GO:0019062 (virion attachment to host cell), GO:0044406 (adhesion of symbiont to host), GO:0044650 (adhesion of symbiont to host cell)
Cellular Component (CC): GO:0005575 (cellular component), GO:0044423 (virion component), GO:0019028 (viral capsid), GO:0019030 (icosahedral viral capsid)
Protein: GTP-binding protein REM 1 (O35929)
Organism: Mus musculus (Mouse)
Function: Promotes endothelial cell sprouting and actin cytoskeletal reorganization (By similarity). May be involved in angiogenesis. May function in Ca(2+) signaling
InterPro domains:
- IPR001806: Small GTPase (family) [71-297]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [78-254]
- IPR005225: Small GTP-binding domain (domain) [81-237]
- IPR017358: Ras-related small G protein, RGK family (family) [1-297]
- IPR051641: RGK GTP-binding regulators (family) [35-297]
Sequence:
MTLNTQQEAKTTLRRRASTPLPLSSRGHQPGRLCTAPSAPSQHPRLGQSVSLNPPVRKPSPAQDGWSSESSDSEGSWEALYRVVLLGDPGVGKTSLASLFAEKQDRDPHEQLGGVYERTLSVDGEDTTLVVMDTWEAEKLDESWCQESCLQAGSAYVIVYSIADRSSFESASELRIQLRRTHQANHVPIILVGNKADLARCREVSVEEGRACAVVFDCKFIETSATLQHNVTELFEGVVRQLRLRRQDNAAPETPSPRRRASLGQRARRFLARLTARSARRRALKARSKSCHNLAVL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0031647 (regulation of protein stability), GO:0050821 (protein stabilization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: RNA binding protein fox-1 homolog 2 (A1A5R1)
Organism: Rattus norvegicus (Rat)
Function: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue- specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity). Together with RNA binding proteins RBPMS and MBNL1/2, activates vascular smooth muscle cells alternative splicing events
Subcellular location: Nucleus. Cytoplasm
InterPro domains:
- IPR047131: RNA binding protein fox-1 homolog 1-like (family) [52-432]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [152-254]
- IPR034237: FOX1, RNA recognition motif (domain) [163-238]
- IPR017325: RNA binding protein fox-1 homolog 1-3 (family) [54-432]
- IPR000504: RNA recognition motif domain (domain) [163-239]
- IPR025670: Fox-1 C-terminal domain (domain) [307-404]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [141-245]
Sequence:
MAEGGQAQQQPPQLGPGAAARGMKRESEVELPVPGAGADGPEPGLSKRPRTEEAADEGMQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSSQPHGEQSSNSPSNQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNEAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0044087 (regulation of cellular component biogenesis), GO:0050807 (regulation of synapse organization), GO:1901888 (regulation of cell junction assembly), GO:0051963 (regulation of synapse assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: DNA-directed RNA polymerase II subunit RPB3 (Q3T0Q3)
Organism: Bos taurus (Bovine)
Function: Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates
Subcellular location: Nucleus
InterPro domains:
- IPR001514: DNA-directed RNA polymerase, 30-40kDa subunit, conserved site (conserved_site) [32-72]
- IPR011263: DNA-directed RNA polymerase, RpoA/D/Rpb3-type (domain) [18-262]
- IPR011262: DNA-directed RNA polymerase, insert domain (domain) [50-175]
- IPR050518: Archaeal Rpo3/Eukaryotic RPB3 RNA Polymerase Subunit (family) [1-267]
- IPR036603: RNA polymerase, RBP11-like subunit (homologous_superfamily) [5-266]
- IPR036643: DNA-directed RNA polymerase, insert domain superfamily (homologous_superfamily) [43-178]
- IPR022842: DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1 (family) [8-263]
Sequence:
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLHDEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDLISNSPRVIPVTSRNRDNDPNDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTAGVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLRPETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0033554 (cellular response to stress), GO:0034605 (cellular response to heat)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140535 (intracellular protein-containing complex), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0030880 (RNA polymerase complex), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043233 (organelle lumen), GO:0055029 (nuclear DNA-directed RNA polymerase complex), GO:0016591 (RNA polymerase II, holoenzyme), GO:0043227 (membrane-bounded organelle), GO:0000428 (DNA-directed RNA polymerase complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0005665 (RNA polymerase II, core complex), GO:0070013 (intracellular organelle lumen), GO:0005736 (RNA polymerase I complex), GO:0005730 (nucleolus), GO:0005634 (nucleus), GO:0031981 (nuclear lumen)
Protein: DNA-directed RNA polymerase II subunit RPB7 (Q5E9B8)
Organism: Bos taurus (Bovine)
Function: Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2G/RPB7 is part of a subcomplex with POLR2D/RPB4 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4- POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single- stranded DNA and RNA
Subcellular location: Nucleus
InterPro domains:
- IPR005576: RNA polymerase Rpb7-like , N-terminal (domain) [10-64]
- IPR036898: RNA polymerase Rpb7-like, N-terminal domain superfamily (homologous_superfamily) [1-80]
- IPR045113: RNA polymerase subunit Rpb7-like (family) [1-162]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [78-172]
- IPR003029: S1 domain (domain) [79-162]
Sequence:
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQPGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFDPNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0008219 (cell death), GO:0012501 (programmed cell death), GO:0006915 (apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0140535 (intracellular protein-containing complex), GO:0030880 (RNA polymerase complex), GO:0043233 (organelle lumen), GO:0055029 (nuclear DNA-directed RNA polymerase complex), GO:1990234 (transferase complex), GO:0016591 (RNA polymerase II, holoenzyme), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000428 (DNA-directed RNA polymerase complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0005665 (RNA polymerase II, core complex), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Small ribosomal subunit protein eS12 (G1SFR8)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Subunit of the 40S ribosomal complex
Subcellular location: Cytoplasm. Nucleus, nucleolus
InterPro domains:
- IPR047860: Small ribosomal subunit protein eS12, conserved site (conserved_site) [17-35]
- IPR029064: Ribosomal protein eL30-like superfamily (homologous_superfamily) [1-132]
- IPR004038: Ribosomal protein eL8/eL30/eS12/Gadd45 (domain) [17-110]
- IPR000530: Small ribosomal subunit protein eS12 (family) [21-114]
Sequence:
MAEEGIAAGGVMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPMYVKLVEALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQAKDVIEEYFKCKK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0003735 (structural constituent of ribosome)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0010243 (response to organonitrogen compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0044391 (ribosomal subunit), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0043228 (non-membrane-bounded organelle), GO:0022627 (cytosolic small ribosomal subunit), GO:0015935 (small ribosomal subunit), GO:0015934 (large ribosomal subunit), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0022625 (cytosolic large ribosomal subunit), GO:0005840 (ribosome)