Protein: RCG50085 (A6JVP8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR011500: GPCR, family 3, nine cysteines domain (domain) [546-599]
- IPR038550: GPCR, family 3, nine cysteines domain superfamily (homologous_superfamily) [545-621]
- IPR017978: GPCR family 3, C-terminal (domain) [614-875]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [48-538]
- IPR000337: GPCR, family 3 (family) [47-830]
- IPR001828: Receptor, ligand binding region (domain) [87-504]
- IPR000068: GPCR, family 3, extracellular calcium-sensing receptor-related (family) [46-878]
Sequence:
MASQKICLALGFLAFLWAELGAQNKTEELQCRLMAKFNLSGYVDAKNHSLVIAGLFPIHSRIIPVDESILEPVSPMCEGFNFRGFRWMKTMIHTIKEINARKDILPNHTLGYQIFDSCYTISKAMESSLVFLTGQEEFKPNFRNSTGSTLAAMVGAGGSSLSVAASRILGLYYMPQVGYTSSCSILSDKFQFPSYLRVVPSDKIQSEAMVNLIKHFGWVWVGAVAADDDYGKYGVKTFKEKMESANLCVAFSETIPKVYSNEKMQKAINAVKNSTAKVIVLYTSDIDLSPFVLELIHHNVTDRTWIASEAWITSALIAKPEYFPYFGGSIGFALPRTTIPGLKEFLYDIHPSKDPNDVLTIEFWQTAFNCTWPNSSVPYNVDHRVNMTGKEDRLYDMSDQLCTGEEKLEDLKNTYLDMTQLRITNNVKQAVYAIAHALDLLSRCQEGYGPFGTNNACAYIPTFDFWQLMYYMKEIKFKSHEEKWVVLDDNGDLKFGHYDILNWQLDDSGEISFVTVGRFNFKTDMFELIIPTNSTIFWNTESSRRPDSFCTQVCPPGTRKGIRQGQPICCFDCIPCADGYVSENPGQRECDPCGEDDWSNAEKSKCVPKLVEFLAYEEALGLTLVILSIFGALVVLAVTVVYVIYRHTPLVKANDRELSFLIQMSLVITVLSSMLFIGKSCNWTCMARQVTLALGFCLCLSSTLGKTISLFFAYRISKSKTRLISMSPIYRKLIVLICVVGEIGVCTAYLVLEPPRMFKNIEPQNVKIIFECNEGSIEFLCAIFGFDVFLALLCFLTTFVARKLPDNYYEGKCITFGMLVFFIVWISFVPAYLSTKGKFKVAVEIFAILASSYGLLGCIFLPKCFIILLRPKRNTDETVGGRVPTVDRSIQLTSASVSSELNNTAVSTVLDE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0008527 (taste receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0042592 (homeostatic process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0055085 (transmembrane transport), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0065008 (regulation of biological quality), GO:0019725 (cellular homeostasis), GO:0009719 (response to endogenous stimulus), GO:0008219 (cell death), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0003008 (system process), GO:0048878 (chemical homeostasis), GO:0001503 (ossification), GO:0006950 (response to stress), GO:0051606 (detection of stimulus), GO:0001763 (morphogenesis of a branching structure), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0001666 (response to hypoxia), GO:0032103 (positive regulation of response to external stimulus), GO:0012501 (programmed cell death), GO:0009593 (detection of chemical stimulus), GO:0048729 (tissue morphogenesis), GO:0051047 (positive regulation of secretion), GO:0098660 (inorganic ion transmembrane transport), GO:0070482 (response to oxygen levels), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0032101 (regulation of response to external stimulus), GO:0034220 (monoatomic ion transmembrane transport), GO:0003013 (circulatory system process), GO:0035295 (tube development), GO:0055082 (intracellular chemical homeostasis), GO:0010035 (response to inorganic substance), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0043270 (positive regulation of monoatomic ion transport), GO:0031668 (cellular response to extracellular stimulus), GO:0071496 (cellular response to external stimulus), GO:0090066 (regulation of anatomical structure size), GO:0008284 (positive regulation of cell population proliferation), GO:1902074 (response to salt), GO:0035239 (tube morphogenesis), GO:0050801 (monoatomic ion homeostasis), GO:0009967 (positive regulation of signal transduction), GO:1903530 (regulation of secretion by cell), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0035556 (intracellular signal transduction), GO:0046887 (positive regulation of hormone secretion), GO:0050920 (regulation of chemotaxis), GO:0060341 (regulation of cellular localization), GO:0033500 (carbohydrate homeostasis), GO:0061138 (morphogenesis of a branching epithelium), GO:1901700 (response to oxygen-containing compound), GO:0098771 (inorganic ion homeostasis), GO:0010817 (regulation of hormone levels), GO:0010033 (response to organic substance), GO:0071402 (cellular response to lipoprotein particle stimulus), GO:0046883 (regulation of hormone secretion), GO:0009991 (response to extracellular stimulus), GO:0042127 (regulation of cell population proliferation), GO:0007584 (response to nutrient), GO:0009888 (tissue development), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0045907 (positive regulation of vasoconstriction), GO:0010647 (positive regulation of cell communication), GO:0055094 (response to lipoprotein particle), GO:0051222 (positive regulation of protein transport), GO:0050921 (positive regulation of chemotaxis), GO:0002931 (response to ischemia), GO:1903532 (positive regulation of secretion by cell), GO:1901652 (response to peptide), GO:0071453 (cellular response to oxygen levels), GO:0008015 (blood circulation), GO:1904951 (positive regulation of establishment of protein localization), GO:0061448 (connective tissue development), GO:0070201 (regulation of establishment of protein localization), GO:0000165 (MAPK cascade), GO:0002793 (positive regulation of peptide secretion), GO:0071702 (organic substance transport), GO:0002009 (morphogenesis of an epithelium), GO:0007200 (phospholipase C-activating G protein-coupled receptor signaling pathway), GO:0033273 (response to vitamin), GO:0015698 (inorganic anion transport), GO:1903522 (regulation of blood circulation), GO:0048754 (branching morphogenesis of an epithelial tube), GO:0031098 (stress-activated protein kinase signaling cascade), GO:0050927 (positive regulation of positive chemotaxis), GO:0051592 (response to calcium ion), GO:0051223 (regulation of protein transport), GO:0090276 (regulation of peptide hormone secretion), GO:0031667 (response to nutrient levels), GO:0051928 (positive regulation of calcium ion transport), GO:0036293 (response to decreased oxygen levels), GO:1902533 (positive regulation of intracellular signal transduction), GO:0098661 (inorganic anion transmembrane transport), GO:0050708 (regulation of protein secretion), GO:1901701 (cellular response to oxygen-containing compound), GO:0010038 (response to metal ion), GO:0071456 (cellular response to hypoxia), GO:0071417 (cellular response to organonitrogen compound), GO:0003018 (vascular process in circulatory system), GO:0050926 (regulation of positive chemotaxis), GO:0009743 (response to carbohydrate), GO:0060562 (epithelial tube morphogenesis), GO:0060612 (adipose tissue development), GO:0071310 (cellular response to organic substance), GO:0035728 (response to hepatocyte growth factor), GO:1901699 (cellular response to nitrogen compound), GO:0071774 (response to fibroblast growth factor), GO:0046903 (secretion), GO:0032880 (regulation of protein localization), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0050714 (positive regulation of protein secretion), GO:0033280 (response to vitamin D), GO:0055074 (calcium ion homeostasis), GO:0035150 (regulation of tube size), GO:0010243 (response to organonitrogen compound), GO:0090087 (regulation of peptide transport), GO:0055080 (monoatomic cation homeostasis), GO:0033993 (response to lipid), GO:0071404 (cellular response to low-density lipoprotein particle stimulus), GO:0042593 (glucose homeostasis), GO:0006915 (apoptotic process), GO:0031670 (cellular response to nutrient), GO:0051046 (regulation of secretion), GO:0090277 (positive regulation of peptide hormone secretion), GO:0014070 (response to organic cyclic compound), GO:0043269 (regulation of monoatomic ion transport), GO:0098656 (monoatomic anion transmembrane transport), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0060429 (epithelium development), GO:0031669 (cellular response to nutrient levels), GO:0001678 (intracellular glucose homeostasis), GO:0071363 (cellular response to growth factor stimulus), GO:1902531 (regulation of intracellular signal transduction), GO:0006821 (chloride transport), GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway), GO:0071305 (cellular response to vitamin D), GO:0032024 (positive regulation of insulin secretion), GO:0051403 (stress-activated MAPK cascade), GO:0050796 (regulation of insulin secretion), GO:0035729 (cellular response to hepatocyte growth factor stimulus), GO:0071333 (cellular response to glucose stimulus), GO:0010959 (regulation of metal ion transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0097746 (blood vessel diameter maintenance), GO:0046717 (acid secretion), GO:0035296 (regulation of tube diameter), GO:0043410 (positive regulation of MAPK cascade), GO:0090280 (positive regulation of calcium ion import), GO:1902476 (chloride transmembrane transport), GO:0006874 (intracellular calcium ion homeostasis), GO:0015849 (organic acid transport), GO:0006820 (monoatomic anion transport), GO:0043408 (regulation of MAPK cascade), GO:0015711 (organic anion transport), GO:0019229 (regulation of vasoconstriction), GO:0071322 (cellular response to carbohydrate stimulus), GO:0034284 (response to monosaccharide), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:1901653 (cellular response to peptide), GO:0002791 (regulation of peptide secretion), GO:0036294 (cellular response to decreased oxygen levels), GO:0071295 (cellular response to vitamin)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0036477 (somatodendritic compartment), GO:0042995 (cell projection), GO:0097447 (dendritic tree), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0030425 (dendrite)