Protein: Tyrosine 3-monooxygenase (A0A8M2BBY7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, axon. Cytoplasm, perinuclear region
InterPro domains:
- IPR018301: Aromatic amino acid hydroxylase, iron/copper binding site (binding_site) [300-311]
- IPR036329: Aromatic amino acid monoxygenase, C-terminal domain superfamily (homologous_superfamily) [137-469]
- IPR019773: Tyrosine 3-monooxygenase-like (family) [11-471]
- IPR036951: Aromatic amino acid hydroxylase superfamily (homologous_superfamily) [131-471]
- IPR041903: Tyrosine 3-monooxygenase, catalytic domain (domain) [139-436]
- IPR001273: Aromatic amino acid hydroxylase (family) [47-471]
- IPR019774: Aromatic amino acid hydroxylase, C-terminal (domain) [125-471]
- IPR005962: Tyrosine 3-monooxygenase (family) [16-469]
- IPR045865: ACT-like domain (homologous_superfamily) [47-143]
- IPR049321: Tyrosine 3-monooxygenase-like, ACT domain (domain) [53-122]
Sequence:
MKSDSIAQNVPLSGRKRSLIEDARRDRESGSSSPGPSRCGDSFVFEEEKTGKITLNILFALKNEKNAGFFKAGKVFETFETKLLHLESRASRKSKRSSGEDLEFFMRCEVHCSDTDIFINSLKRVADDVRIVQEEKTPWFPKKISDLDTCNHLITKYDPDLDQDHPGFSDSEYRKRRGFISEMAFNYKHGDPLPVVEYTPEENATWREVYRTLRSLYPSHACRQFLEALTQLESERLYGEDQIPQLREVSAFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHPSAPMHSPEPDCCHELLGHIPMLADQEFAQFSQEIGLVSLGASDEDIEKLSTLYWFTVEFGLCKQNGAVKAYGAGLLSSYGELLYALSNEPQYKPFDPAETAVQPYQDQSYQPVYFVSESFEDAKQKLRRYSSTIQTPFSIRYDPYTCSMEVLDEPSKIQNALGQMRDDLKILHKALGRLGQK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0004497 (monooxygenase activity), GO:0016714 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0097164 (ammonium ion metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:1901160 (primary amino compound metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0042430 (indole-containing compound metabolic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0009308 (amine metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0042428 (serotonin metabolic process), GO:0018958 (phenol-containing compound metabolic process), GO:0042435 (indole-containing compound biosynthetic process), GO:0006576 (biogenic amine metabolic process), GO:0042427 (serotonin biosynthetic process), GO:0009309 (amine biosynthetic process), GO:0009712 (catechol-containing compound metabolic process), GO:0046189 (phenol-containing compound biosynthetic process), GO:1901162 (primary amino compound biosynthetic process), GO:0042401 (biogenic amine biosynthetic process), GO:0006584 (catecholamine metabolic process), GO:0009713 (catechol-containing compound biosynthetic process), GO:0042417 (dopamine metabolic process), GO:0042423 (catecholamine biosynthetic process), GO:0042416 (dopamine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)