Protein: Thrombomodulin (F7EK87)
Organism: Rattus norvegicus (Rat)
Function: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated
Subcellular location: Membrane; Single- pass type I membrane protein
InterPro domains:
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [339-350]
- IPR057350: Thrombomodulin-like domain (domain) [174-238]
- IPR016187: C-type lectin fold (homologous_superfamily) [24-175]
- IPR000742: EGF-like domain (domain) [243-480]
- IPR026823: Complement Clr-like EGF domain (domain) [304-326]
- IPR018097: EGF-like calcium-binding, conserved site (conserved_site) [324-463]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [242-368]
- IPR049883: NOTCH1 EGF-like calcium-binding domain (domain) [440-467]
- IPR052126: Spindle_Organization_and_Thrombomodulin (family) [3-428]
- IPR015149: Thrombomodulin-like, EGF-like (domain) [405-438]
- IPR001304: C-type lectin-like (domain) [24-167]
- IPR016186: C-type lectin-like/link domain superfamily (homologous_superfamily) [18-168]
- IPR001881: EGF-like calcium-binding domain (domain) [275-480]
Sequence:
MLGVFLLGVLAPAGLGISALAKLQPKGSQCVGNECFALFQDPVTFLDASQACQRLQGHLMTVRSSVAADVISLLVSDSSMDSRPWIGLQLPQGCGDPVHLGPLRGFQWVTGDNHTSYSRWARPNDQSPPLCGPLCVTVSTATEAAPGEPAWEEKPCENETKGFLCEFYFAAFCRPLRVNTRDPEGAHISSTYNTPLGVSGADFQTLPIGSSATVAPFGLELVCRALPGTSEGHWTREVTGAWNCSVENGGCEYMCNRSANGPRCVCPSGGDLQADGRSCAKPVAQLCNELCQHFCVNNSDVPGSYSCMCETGYQLAADGHRCEDVDDCKQGPNPCPQLCSNTEGGFECRCYDGYELVDGECVEQLDPCFRSKCEYQCQPVNSTHYNCICAEGFAPKLDDPDRCEMFCNETSCPADCDPNSPSFCQCPEGFILDEGSICTDIDECSQGECLTNECRNLPGSYECICGPDTALAGQISKDCDPIPVLEDSEDGGSGEHPSSNPTVVSSTVPPSARPMHSGVLIGISIASLSLVVALLALLCHLRKKQGTARAELEYKCTSSAKEVVLQHVRTDRTLQKF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:1901700 (response to oxygen-containing compound), GO:0043207 (response to external biotic stimulus), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0009314 (response to radiation), GO:0009617 (response to bacterium), GO:0046683 (response to organophosphorus), GO:0002237 (response to molecule of bacterial origin), GO:0051591 (response to cAMP), GO:0032496 (response to lipopolysaccharide), GO:0014070 (response to organic cyclic compound), GO:0010243 (response to organonitrogen compound), GO:0010212 (response to ionizing radiation), GO:0033993 (response to lipid), GO:0010165 (response to X-ray), GO:0014074 (response to purine-containing compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0098590 (plasma membrane region), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0016327 (apicolateral plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle)