Protein: Succinate dehydrogenase [rhodoquinone] flavoprotein subunit 1, mitochondrial (Q33862)
Organism: Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Function: Flavoprotein (Fp) subunit of the mitochondrial electron transport chain complex II which, together with the iron-sulfur protein (Ip) subunit forms the catalytic core of the complex. During the parasitic larvae and adult stages, which occur in an anaerobic environment, acts as a fumarate reductase by transferring electrons from rhodoquinol to fumarate
Subcellular location: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
InterPro domains:
- IPR015939: Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal (domain) [494-644]
- IPR027477: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily (homologous_superfamily) [270-388]
- IPR003953: FAD-dependent oxidoreductase 2, FAD-binding domain (domain) [43-438]
- IPR003952: Fumarate reductase/succinate dehydrogenase, FAD-binding site (binding_site) [77-86]
- IPR011281: Succinate dehydrogenase, flavoprotein subunit (family) [40-645]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [34-467]
- IPR014006: Succinate dehydrogenase/fumarate reductase, flavoprotein subunit (family) [43-626]
- IPR030664: FAD-dependent oxidoreductase SdhA/FrdA/AprA (family) [31-645]
- IPR037099: Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily (homologous_superfamily) [484-645]
Sequence:
MLRAVRALMCRIGARRTLSVSSSRLDVSTSNMAQYKVIDHAYDVVIIGAGGAGLRAAMGLGEAGFKTAVVTKMFPTSSHTTAAQGGINAALGSMNPDDWKWHFYDTAKGSDWLGDQNAMHYLTRNAVEAVTELENFGMPFSSTPEGKIYQSSFGGQSNNYGKGGVAKRTCCVADRTGHSMLHTLYGNSLSCHCTFFIEYFALDLLMDKGSCVGVIALCLEDGTIHRFRSKRTIVATGGYGRAYFSCTTAHMNTGDGTALATRAGIALEDLEFIQFHPTGIYGVGCLITEGSSGEGGFLVNSEGERFMERYAPKAKDLASRDVVSRAETIEIMEGRGVGPEKDHIYLQLHHLPAEQLHQRLPGISETAKIFAGVDVTKEPIPVIPTVHYNMGGIPTNYKAQVIKYTKEGGDKMVPGLYACGECACHSVHGANRLGANSLLDAVVFGRACSINIKEELKPDEKIPELPEGAGEESIANLDAVRYANGDVPTAELRLTMQKTMQKHAGVFSSGDMLAEGVKKMMDLSKELKRLKTTDRSLIWNSDLTESLELQNLMLNATQTIVAAENSKESRGAHARDDFPKREDEYDYSKPIEGQTKSPFEKHWRKHTLTKQDPRTGHITLDYSPVIDKTLDPAEVDWMPPIISSY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:1901265 (nucleoside phosphate binding), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0050660 (flavin adenine dinucleotide binding), GO:0000104 (succinate dehydrogenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044238 (primary metabolic process), GO:0006099 (tricarboxylic acid cycle), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0022900 (electron transport chain), GO:0045333 (cellular respiration), GO:0022904 (respiratory electron transport chain), GO:0009060 (aerobic respiration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)