Protein: Tumor protein p73 (A6IUK8)
Organism: Rattus norvegicus (Rat)
Function: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR036674: p53-like tetramerisation domain superfamily (homologous_superfamily) [391-451]
- IPR002117: p53 tumour suppressor family (family) [48-644]
- IPR012346: p53/RUNT-type transcription factor, DNA-binding domain superfamily (homologous_superfamily) [156-363]
- IPR037612: Tumour protein p73, SAM domain (domain) [534-598]
- IPR010991: p53, tetramerisation domain (domain) [390-429]
- IPR001660: Sterile alpha motif domain (domain) [532-598]
- IPR057064: p53, central conserved site (conserved_site) [302-314]
- IPR011615: p53, DNA-binding domain (domain) [163-353]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [160-351]
- IPR013761: Sterile alpha motif/pointed domain superfamily (homologous_superfamily) [533-600]
Sequence:
MSSPRQLDAYATALPLQATGPPAPLPKSTDPSRAQVQPRMSNGVGEMAQSSSSSSSSSTFEHLWSSLEPDSTYFDLPQPSQGNSEATGSEESNMDVFHLQGMTSSVMAQFNLLSSAMDQMGSRAAPASPYTPEHAASAPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDIVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILVIITLETRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESTTKNGAASKRAFKQSPPAIPALGTNVKKRRHGDEDMFYMHVRGRENFEILMKVKESLELMELVPQPLVDSYRQQQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGVNKLPSVNQLVGQPPPHSSAAGPNLGSMGSGILNSHSHSMPANGEMNGGHSSQTMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIECFTSQGLQSIYHLQNLTIEDLGALKIPDQYRMTIWRGLQDLKQSHDCGQQLLRSSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGAGGVTGPDEWADFGFDLPDCKSRKQPIKEEFTETESH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0045597 (positive regulation of cell differentiation), GO:0010942 (positive regulation of cell death), GO:2000026 (regulation of multicellular organismal development), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0009410 (response to xenobiotic stimulus), GO:0045596 (negative regulation of cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0045595 (regulation of cell differentiation), GO:0010647 (positive regulation of cell communication), GO:0051962 (positive regulation of nervous system development), GO:0010033 (response to organic substance), GO:0072001 (renal system development), GO:0045664 (regulation of neuron differentiation), GO:0010243 (response to organonitrogen compound), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:1902533 (positive regulation of intracellular signal transduction), GO:0050769 (positive regulation of neurogenesis), GO:0051960 (regulation of nervous system development), GO:0045685 (regulation of glial cell differentiation), GO:0045665 (negative regulation of neuron differentiation), GO:0001822 (kidney development), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0048713 (regulation of oligodendrocyte differentiation), GO:0014015 (positive regulation of gliogenesis), GO:0045687 (positive regulation of glial cell differentiation), GO:0043410 (positive regulation of MAPK cascade), GO:0050767 (regulation of neurogenesis), GO:0048714 (positive regulation of oligodendrocyte differentiation), GO:0014013 (regulation of gliogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:0005694 (chromosome)