Protein: RCG60999, isoform CRA_b (A6JJH2)
Organism: Rattus norvegicus (Rat)
Function: Involved in the presentation of foreign antigens to the immune system
Subcellular location: Membrane; Single- pass type I membrane protein
InterPro domains:
- IPR050208: Antigen-presenting and immune regulatory MHC class I-related (family) [14-335]
- IPR003597: Immunoglobulin C1-set (domain) [218-290]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [203-304]
- IPR001039: MHC class I alpha chain, alpha1 alpha2 domains (domain) [80-196]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [205-297]
- IPR011162: MHC classes I/II-like antigen recognition protein (homologous_superfamily) [23-202]
- IPR007110: Immunoglobulin-like domain (domain) [206-292]
- IPR003006: Immunoglobulin/major histocompatibility complex, conserved site (conserved_site) [278-284]
- IPR037055: MHC class I-like antigen recognition-like superfamily (homologous_superfamily) [21-202]
- IPR011161: MHC class I-like antigen recognition-like (domain) [22-200]
Sequence:
MAPRTLLLILAAALAPTQTRAGSHSMRYFDIAVSRPGLGEPRFIIVGYVDDTEFVRFDSDAEKPRYEPRAPWMEPEGPEYWEEQTRRAKEGEQTFRVNLRTALHYYNQSEDRSHTIQRLSGCDVGSDGRLLRGYEQYAYDGRDYIALNEDLKTWTAADFAARISRNKWDQAGVAERLRAYLEGECVEWLRRYLELGKETLLRSDPPKAHVTLHPRPEGDVTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCRVEHEGLPEPLSQRWEPPPSTDSNMETTVIYVVLGAVAIIAAVIIGAVVTVVRKRRRNTGRKGQGTDSSQSSDVSLPDCKA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0033218 (amide binding), GO:0005515 (protein binding), GO:0042277 (peptide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0002520 (immune system development), GO:0048584 (positive regulation of response to stimulus), GO:0002683 (negative regulation of immune system process), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0002507 (tolerance induction), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0031341 (regulation of cell killing), GO:0050777 (negative regulation of immune response), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0032102 (negative regulation of response to external stimulus), GO:0002697 (regulation of immune effector process), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0031343 (positive regulation of cell killing), GO:0050778 (positive regulation of immune response), GO:0032101 (regulation of response to external stimulus), GO:0002698 (negative regulation of immune effector process), GO:0002699 (positive regulation of immune effector process), GO:0002832 (negative regulation of response to biotic stimulus), GO:0002643 (regulation of tolerance induction), GO:0031348 (negative regulation of defense response), GO:0031342 (negative regulation of cell killing), GO:0031347 (regulation of defense response), GO:0045088 (regulation of innate immune response), GO:0002703 (regulation of leukocyte mediated immunity), GO:0001910 (regulation of leukocyte mediated cytotoxicity), GO:0001911 (negative regulation of leukocyte mediated cytotoxicity), GO:0002704 (negative regulation of leukocyte mediated immunity), GO:0002821 (positive regulation of adaptive immune response), GO:0045824 (negative regulation of innate immune response), GO:0002705 (positive regulation of leukocyte mediated immunity), GO:0001912 (positive regulation of leukocyte mediated cytotoxicity), GO:0002819 (regulation of adaptive immune response), GO:0002716 (negative regulation of natural killer cell mediated immunity), GO:0002822 (regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0002706 (regulation of lymphocyte mediated immunity), GO:0002824 (positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0042269 (regulation of natural killer cell mediated cytotoxicity), GO:0002708 (positive regulation of lymphocyte mediated immunity), GO:0045953 (negative regulation of natural killer cell mediated cytotoxicity), GO:0001914 (regulation of T cell mediated cytotoxicity), GO:0001916 (positive regulation of T cell mediated cytotoxicity), GO:0002715 (regulation of natural killer cell mediated immunity), GO:0002707 (negative regulation of lymphocyte mediated immunity), GO:0002711 (positive regulation of T cell mediated immunity), GO:0002709 (regulation of T cell mediated immunity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface)