Protein: Protein disulfide-isomerase (A0A8I5KW33)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum lumen. Melanosome
InterPro domains:
- IPR005792: Protein disulphide isomerase (family) [25-468]
- IPR041868: Protein disulfide-isomerase A3, first redox inactive TRX-like domain b (domain) [135-240]
- IPR017937: Thioredoxin, conserved site (conserved_site) [49-416]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [24-462]
- IPR005788: Protein disulfide-isomerase, thioredoxin-like domain (domain) [30-131]
- IPR013766: Thioredoxin domain (domain) [19-487]
Sequence:
MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEVSELSHIPTNIYTDVNTQP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:0016491 (oxidoreductase activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0043169 (cation binding), GO:0046906 (tetrapyrrole binding), GO:0046983 (protein dimerization activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0015035 (protein-disulfide reductase activity), GO:0051241 (negative regulation of multicellular organismal process), GO:0015036 (disulfide oxidoreductase activity), GO:0020037 (heme binding), GO:0042803 (protein homodimerization activity), GO:0046872 (metal ion binding), GO:0031420 (alkali metal ion binding), GO:0005509 (calcium ion binding), GO:0031402 (sodium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0019882 (antigen processing and presentation), GO:0006457 (protein folding), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0048002 (antigen processing and presentation of peptide antigen), GO:0034975 (protein folding in endoplasmic reticulum), GO:0002474 (antigen processing and presentation of peptide antigen via MHC class I), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)