Protein: DNA nucleotidylexotransferase (A6JH71)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus
InterPro domains:
- IPR002054: DNA-directed DNA polymerase X (domain) [163-496]
- IPR027421: DNA polymerase lambda lyase domain superfamily (homologous_superfamily) [149-242]
- IPR027292: DNA nucleotidylexotransferase (TdT) (family) [1-484]
- IPR010996: Crossover junction endonuclease MUS81-like, HHH domain (domain) [163-233]
- IPR029398: DNA polymerase beta, thumb domain (domain) [446-481]
- IPR036420: BRCT domain superfamily (homologous_superfamily) [25-126]
- IPR037160: DNA polymerase, thumb domain superfamily (homologous_superfamily) [441-495]
- IPR001726: DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu (family) [1-484]
- IPR022312: DNA polymerase family X (family) [21-485]
- IPR002934: Polymerase, nucleotidyl transferase domain (domain) [315-404]
- IPR019843: DNA polymerase family X, binding site (binding_site) [332-351]
- IPR018944: DNA polymerase lambda, fingers domain (domain) [250-299]
- IPR043519: Nucleotidyltransferase superfamily (homologous_superfamily) [302-482]
- IPR001357: BRCT domain (domain) [27-124]
Sequence:
MDPLQAVHLGPRKKRPRQTGASGASTPHDIRFRDLVLFILEKKMGTTRRAFLMELARRKGFRVENELSDSVTHIVAENNSGSDVLEWLQLQNIKASSEFELLDISWLIECMGAGKPVEMAGRHQLVVRRNPSLSPVPGSQTVPPPPMQKISQYACQRRTTLNNHNQLFTDAFDILAENYEFRENEVSCLPFMRAASVLKSLSFPIVSMKDIEGIPCLGDKVKCVIEGIIEDGESSEVKAVLNDERYKSFKLFTSVFGVGLKTAEKWFRMGFRTLSKIKSDKSLRFTHMQKAGFLYYEDLVSCVNRAEAEAVSMLVKEAVVAFLPDALVTMTGGFRRGKMTGHDVDFLITSPEATEEEEQQLLHKVTNFWRQQGLLLYCDIIESTFEKFKLPSRKVDALDHFQKCFLILKLHRGLVRSEESGQQEGKDWKAIRVDLVMCPYERRAFALLGWTGSRQFERDLRRYATHERKMMLDNHALYDKTKRLSQFHLCMGKCQNHRKP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0140097 (catalytic activity, acting on DNA), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016779 (nucleotidyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:1902074 (response to salt), GO:0046683 (response to organophosphorus), GO:0033198 (response to ATP), GO:0014070 (response to organic cyclic compound), GO:0010243 (response to organonitrogen compound), GO:0014074 (response to purine-containing compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016363 (nuclear matrix), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0034399 (nuclear periphery), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0000791 (euchromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus)