Protein: Protein unc-80 homolog (Q9VB11)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the na (narrow abdomen) sodium channel complex. In the circadian clock neurons it functions with na and unc79 to promote circadian rhythmicity
Subcellular location: Membrane; Multi-pass membrane protein
InterPro domains:
- IPR045852: Protein UNC80, central region (domain) [1179-1920]
- IPR031542: Cation channel complex component UNC80, N-terminal (domain) [53-260]
- IPR046460: Protein UNC80, C-terminal (domain) [1926-3002]
Sequence:
MVTNAAGTAATGGATSNTTNNNNLQTNNNSHGANNNNDDFDFDQDSGLQDLGLPVSVQTFLWRQIAPFIRPKLGKLHESTCLFCQHAPGHHESKEACKSFEKVLVQNIQFGLSPPLTKGLGVIPRWRLLQGALPHVMHACAALLYNRVKDMQAIGPVETKLLYTMQWILLYAAEECADDEGGEDLGLGDAAEPKSKSIDQYLFSVPTITLFVYLFAPIIHHLKESDFQNFRLENGIKLWQGMWDNRAPGAPCFTAPVKPKARNLLCAPTPKGSTDVFPARKHSLSADAMSPKADSPQSGISDYGRQDEEGSWVSSPKEFAFPETIPEEASSVEDERVVIFRLPSAPQLMDNSFFTADASLLQQQQSQSRRGSRQSMNSRDKDKVPSTKFEFDQQELMRGASMKEKRSASIEKETDSDKSESIKADVSAATFLDVAVLRCLFISHWQEEGIFWSLQYLYNRLSDIGEEAAITLNQPRKRSNSLPIPQIEISLYQGPGSNSRDSPGSSVVKDYIEIPDPSPTVTACVAEEPQSAPSTTERRGSEKKKRVKMADLRAFVETKMFSKSEKNLEKVGLDTNSANGKTPLQHAEYHRSLDTGEKKLSRSASMISREPASNLIKGKSMPSLRFYRYVEPPKAPRPSQATCPRSTAFYPRNPIITVTEHTPTPSPDYMKRQGSIDSQLDALSNGGSIAGMTGNGGGNGSTGMGSSTTRYRGQMLRSHTDSHIDYTGVDESEAPGSSFYITRDGGIDYEIILLAISNVFKRDPAQVCSLRVLEAGLNICELLIEMGVLKLGEHAHEISMSITRRALQVLGCPHGCNDGVRGPPADFLRNQCQKILSRMLRQAGQRTKRFMQEMVKTSPLPELIDYFHAFLAFCVDPSSLLSPLSQGGYSTNFSGGMSGGAEAQVVGAVFKPLVSRFVEASKDLKGPENIALYGDIRQLVTYVKGAHGGPFRLVALSGILAVTPRPHKKGPSAQTTRVIRHIPQANANQSLQNDDNRSQRRLLLKKRSTSSACASLLETEACEEHYKTSQSPLSNFRRRTTGVRPTLTPRHSERALLSDSTSSSERNSLGRLSGLVRWFRGTPKEASSIDLEIGSLNPEISSTFMRHASLKIQRGRSSDGIGRSIQRAKRRVERRLNRFGGIVKGKKKVGGIEETADFSRRSSSDMCDGPRESEVVILKERKLVPTEPVRVGMLRLSFLLETCAPGSFPDPQLVAAVLDLPQAPLVARATFLLECAHFVHLCNKGQWPAWMKQNVGSYRASGANINLNQMKQQVSQTSARRTHILQRAAGKMFHQWAEMVGARLEEILFTERLQYEAVNASLTDPEKQRELLQQDEEEDFLDETSVNPHGNDCPHSLKLIACVLLFEITAFLRDTYLMLPKTSKLIHRDKPAPWEKVYREANRRWSMALSSMGHSQTSAQSLQSIAAGNDGAGQSERKISFVLHEPDNESENSSNTTLTKEGEEARRPTTSAVRPFLLRRGTATTTGGSFKRRSLKLRRNTKDSKDIETDFNMQSRRKVSSLSDRSDTSEQGMISGGEESPGILSDDQQPESPTDSNENDDTAKNMPWLKAIIDLMSSYNYYCTHKGYCHPFCYKRHMRSCTRLVKATRKVYGEEFGFTFDADHPNVEPTIITSSKPHTSRARSTRKVSEQSSTQTSPSKRKDSLSRKDRISDDPDLEMAEKLAKAFRQEKEKKMQEEPPILKFIRIHIRNLFHFPLATLLKGAVVLTEEMVIEAMPAAWELLLETNHDTATSSAAVFLMGSVKAQNFAFDIMQRALKHKDPDIRIGAIQRYLVLWKCRFHVWPRMEENAHDVTFKVPPGGIEFTLPSPKIGIESLPVVDPPWMPVQQTKDMDVTLNQDRHRSLVTATKSRKMQQTEAIRNALRQQRDKQRAERHSFLITMIPISQQASHEPGMEKLEDHEIEEDLDGTRMSSHLHHAHSLFPSVLCSSVMQIVGCLDDAAIGSDGNAVYEIAYQVIWVCLVEESALFLRYVFERLTRDRQDQMFKLLRHLIRFVPRLPQQAAFALYNSIIGYIMFYVRSSNELKQELVGSALSVLWMVVHSVHGIMFKDLKQILRKEQCDASILLTANVPAAKKIVVHGPADDDYNIPSQFPVQEDTLFCQLLKEALDYYPIDEKNTSHYCLVDYKSSKILNPNWYIRDLYFFKRSQYPEVRLMLMRPEESFLALQKQELTKKFVEIGKVHLTWAILKNVDMVVQRVVFLHEELMKLPSFPRKALEVDLDLHHGGEYGKVLLGLDVLHKFMWVRLIARMFEAMAGNFAYSADIQLFLNVLSGASILHAEDSCIMRYVMATFINAAFNFKNIFSTNGYFMIMPTLLQVYSLHQTNKLITTTIEYAVKQFYLLNRKPFILQMFGSVSAILDTDEDGTYGEAHKVQSSCLFNLLLSLEDPSPDPLNIAELVKEPKPLKAIDFCYHDEDDDVTVLDCITLCVMVVSYSAESTRGYQMLIILEAILPCYLQQIQSPSYIPLQGKSERDIILQLAVAIRTMVHNCEGLAKSYNGPYRNSPEHKGSSQRNCSRGPPCSPGLDFEEETHPKYMTDARTKNMMDSAEDSEMIRTEYRRPRDVLLSVVADFLTKSTVRLAELAKKMPSDTKPTEVLDAKCHIRLADIAHSLLKVSPYDPESMACRGLQRYMQAVLPRAEWSNDTLRNALVTILRRIDKVFLKISKKPSIRRNTDWEAAAGLLKGIHETIIRHSYVLHWQQMKTLISTVQNLIVNEPGIPEGVSSAGAALMSQNPPAFFCSAVVRLVALQVVSPVDCFSLVQICGGSSEFATQEKAEGFLMHLIMPLCLKVCSGRGVSDVGELKMSDVSFLLTAVLNAMSPPAGRTGQAVSQINRVTGDLRAGSLTFTGSRDAKRPARISGSLYQAAFLALRIVCICFESRLSNEWPRIVRVMRDLGRRNEAAPDLWSFMEFVVTHRTPLYIVLLPFILHKISQPPIGDHERHMQFIIRERLRGTPPQGGIKSKGALLLELARELRDLRDELEEKRYDRESSEQKKSDTPAATSAAEAHKSQQRPSLISIFTGTTTGQASHSHVSAVPIDSRSGSGGICTPSDTLSQQTLHPPRESLSSSSTGRDPHTTTSESQSGEADAGSAPTLVGATPSGSGHGSGGGIGTGAASAVPSHLSHSQSLQQAPFKAQPPKLRFVSSVEFRHSSGETSTTPLSPESPAEDSSGDHTRSRLQRSKAASRKTFRLKRSRLTPMEPPSIVTSQEEQAPQAQAKTLGEISWDSVSQTSSTSGYRDNNSLQTGLLSPDGSLGGLTLGRSPSQHSLLMVFEGQDEDTLI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0048511 (rhythmic process), GO:0007610 (behavior), GO:0007623 (circadian rhythm), GO:0007626 (locomotory behavior), GO:0048512 (circadian behavior), GO:0007622 (rhythmic behavior), GO:0045475 (locomotor rhythm)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:1902495 (transmembrane transporter complex), GO:0120025 (plasma membrane bounded cell projection), GO:0034702 (ion channel complex), GO:0043005 (neuron projection), GO:0034703 (cation channel complex), GO:0030424 (axon)