Protein: Voltage-dependent L-type calcium channel subunit alpha (A0A8M9QD03)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR050599: Voltage-dependent calcium channel alpha-1 subunit (family) [760-1709]
- IPR031688: Voltage-gated calcium channel subunit alpha, C-terminal (domain) [1794-2004]
- IPR005821: Ion transport domain (domain) [78-1413]
- IPR031649: Voltage-dependent L-type calcium channel, IQ-associated domain (domain) [1423-1476]
- IPR005446: Voltage-dependent calcium channel, L-type, alpha-1 subunit (family) [106-674]
- IPR014873: Voltage-dependent calcium channel, alpha-1 subunit, IQ domain (domain) [1486-1571]
- IPR002077: Voltage-dependent calcium channel, alpha-1 subunit (family) [219-1338]
- IPR027359: Voltage-dependent channel domain superfamily (homologous_superfamily) [70-1277]
Sequence:
MSANGPAPPAATPAAPPAAAVPVPSVVPVGSLAQKKRAQYAKSKKQGSSANTRPQRALFCLNLNNPIRRACISLVEWKPFDIFILIAIFANCMALAVYVPFPEDDSNSTNHDLETVEYAFLIIFTIETFLKIIAYGLVMHQNAYVRNGWNMLDFVIVVIGLFSVVLEVLTKEGGEKEEVGENLSAHGHGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHASCYFQGTDILEDEPAPCAVNGHGRTCPINGTLCKEGWQGPNGGITNFDNFMFAMLTVFQCITMEGWTDVLYWMNDAMGLELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEEEESKRNRVTLASLMEKKKKGFGWFSQSSDTHASMPASETESMNTENEKGEDEKATCCGPTCQKISKSKFSRRWRRWNRLCRRNCRLAVKSVPFYWLVIILVFLNTLTISSEHYNQPMWLTQVQDVANKVLLAMFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVEFEIMSPLGISVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQVFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTDDTKKPDEIDEIEDEAKAGEEDEKDNAEEDEEEPDVPAGPRPKISELVKKEKITPIPEGSAFFIFSNTNPVRVACHKLINHHIFTNLILVFIMLSSASLAAEDPIRNFSARNIILGYFDYAFTAIFTVEIVLKMTTYGAFLHKGAFCRNYFNLLDLLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCNDEAKSSPEECKGTYIMYKEGDVNQPIIQKRHWHNSDFNFDNVLMAMMALFTVSTFEGWPALLYKAIDSNRENMGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSTGFEYIMFVLILLNTICLAVQHYGQSELFNYVMDILNMVFTAVFTVEMVLKLIAFKPRHYFTDAWNTFDALIVVGSVVDIAITEVNPTEAPQVDESGNTEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIAMVDHTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACMPGKLCDPESDYNPGEEMTCGSSFAIIYFITFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEEGLVGVHPAQNNTAIALQAGLRTLHDIGPEIRRAISCDLQDDELVDFIPEEDEEIYRRNGGLFGNHINHINGDPRRSSGHQTNATQRPLQVQPPPHYVHMEQPVGRLGRANAMAQQNHHRHHHHHHHHHHHNNSYNKSPKSTNINLNNANVSSLPNGGHNRYYEHAPANGYPGSYYGEYDKPRTPHGQRSQGSDRRRPTIRREEEYEEDRYSGEYYSGEEFYEDDSMLSGDRYPNSDQEYETPRGYHHPDSYYEDDEQPLYHDSHRSPKRRLLPPTPQGNRRPSFNFECLRRQSSQDDLPHQRTALPLHLMQHQVMAVAGLDSSRAHRLSPTRSTRSWASPPPTPASKDRTPYYTPLIRVDRPLRDSASSSHSSIRKSSWYTDDPEYQQRNFSPVHLQVPPEYRNQYLQKRGSATSLVEAVLISEGLGRYAKDPKFVAATKHEIADACEMTIDEMESAASHLLNGGITPVVNGVNVFPILGHRDYELQDVSASYSDEEPEPEPRPRYEEDLADEMICITTL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005262 (calcium channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005245 (voltage-gated calcium channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0051606 (detection of stimulus), GO:0003008 (system process), GO:0009581 (detection of external stimulus), GO:0009582 (detection of abiotic stimulus), GO:0016043 (cellular component organization), GO:0050877 (nervous system process), GO:0009612 (response to mechanical stimulus), GO:0050906 (detection of stimulus involved in sensory perception), GO:0050974 (detection of mechanical stimulus involved in sensory perception), GO:0050905 (neuromuscular process), GO:0050982 (detection of mechanical stimulus), GO:0034330 (cell junction organization), GO:0007600 (sensory perception), GO:0050910 (detection of mechanical stimulus involved in sensory perception of sound), GO:0050808 (synapse organization), GO:0050954 (sensory perception of mechanical stimulus), GO:0050885 (neuromuscular process controlling balance), GO:0007605 (sensory perception of sound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0009925 (basal plasma membrane), GO:0045202 (synapse), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0097470 (ribbon synapse)