Protein: cGMP-dependent protein kinase (A6I0Z1)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [280-292]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [11-128]
- IPR035014: cGMP-dependent protein kinase, catalytic domain (domain) [166-426]
- IPR000719: Protein kinase domain (domain) [160-419]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [3-136]
- IPR002374: cGMP-dependent kinase (family) [27-135]
- IPR000961: AGC-kinase, C-terminal (domain) [420-471]
- IPR018488: Cyclic nucleotide-binding, conserved site (conserved_site) [48-107]
- IPR000595: Cyclic nucleotide-binding domain (domain) [21-143]
- IPR017441: Protein kinase, ATP binding site (binding_site) [166-190]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [154-460]
Sequence:
MMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding), GO:0051019 (mitogen-activated protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0022414 (reproductive process), GO:0040007 (growth), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0016049 (cell growth), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0040013 (negative regulation of locomotion), GO:0048523 (negative regulation of cellular process), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0051051 (negative regulation of transport), GO:0035265 (organ growth), GO:0042752 (regulation of circadian rhythm), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0003008 (system process), GO:0065009 (regulation of molecular function), GO:0048609 (multicellular organismal reproductive process), GO:0042753 (positive regulation of circadian rhythm), GO:0048522 (positive regulation of cellular process), GO:2000145 (regulation of cell motility), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0055017 (cardiac muscle tissue growth), GO:0048513 (animal organ development), GO:0044057 (regulation of system process), GO:0034764 (positive regulation of transmembrane transport), GO:0060419 (heart growth), GO:0003013 (circulatory system process), GO:0051048 (negative regulation of secretion), GO:0021549 (cerebellum development), GO:0048588 (developmental cell growth), GO:1903523 (negative regulation of blood circulation), GO:0007204 (positive regulation of cytosolic calcium ion concentration), GO:0043270 (positive regulation of monoatomic ion transport), GO:0062014 (negative regulation of small molecule metabolic process), GO:0090066 (regulation of anatomical structure size), GO:1903531 (negative regulation of secretion by cell), GO:2000146 (negative regulation of cell motility), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:1903530 (regulation of secretion by cell), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0032891 (negative regulation of organic acid transport), GO:0032409 (regulation of transporter activity), GO:0048515 (spermatid differentiation), GO:0034762 (regulation of transmembrane transport), GO:0030902 (hindbrain development), GO:0031324 (negative regulation of cellular metabolic process), GO:0022037 (metencephalon development), GO:0051953 (negative regulation of amine transport), GO:0045912 (negative regulation of carbohydrate metabolic process), GO:0007283 (spermatogenesis), GO:0003012 (muscle system process), GO:0061061 (muscle structure development), GO:0009888 (tissue development), GO:0060322 (head development), GO:0032411 (positive regulation of transporter activity), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0055006 (cardiac cell development), GO:0014896 (muscle hypertrophy), GO:0008015 (blood circulation), GO:0010675 (regulation of cellular carbohydrate metabolic process), GO:0003301 (physiological cardiac muscle hypertrophy), GO:0007286 (spermatid development), GO:0030334 (regulation of cell migration), GO:1903522 (regulation of blood circulation), GO:0007420 (brain development), GO:0007399 (nervous system development), GO:0042692 (muscle cell differentiation), GO:0072359 (circulatory system development), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0010677 (negative regulation of cellular carbohydrate metabolic process), GO:0007417 (central nervous system development), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051956 (negative regulation of amino acid transport), GO:0007507 (heart development), GO:0003018 (vascular process in circulatory system), GO:0051952 (regulation of amine transport), GO:0061049 (cell growth involved in cardiac muscle cell development), GO:0010565 (regulation of cellular ketone metabolic process), GO:0043255 (regulation of carbohydrate biosynthetic process), GO:0055001 (muscle cell development), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:1902930 (regulation of alcohol biosynthetic process), GO:0006109 (regulation of carbohydrate metabolic process), GO:0046890 (regulation of lipid biosynthetic process), GO:0045822 (negative regulation of heart contraction), GO:0030336 (negative regulation of cell migration), GO:0035150 (regulation of tube size), GO:0014048 (regulation of glutamate secretion), GO:0034767 (positive regulation of monoatomic ion transmembrane transport), GO:0043268 (positive regulation of potassium ion transport), GO:0032890 (regulation of organic acid transport), GO:1902931 (negative regulation of alcohol biosynthetic process), GO:0032414 (positive regulation of ion transmembrane transporter activity), GO:0060537 (muscle tissue development), GO:0031326 (regulation of cellular biosynthetic process), GO:0051046 (regulation of secretion), GO:0022898 (regulation of transmembrane transporter activity), GO:0043269 (regulation of monoatomic ion transport), GO:0019216 (regulation of lipid metabolic process), GO:0048232 (male gamete generation), GO:0035051 (cardiocyte differentiation), GO:0051174 (regulation of phosphorus metabolic process), GO:0014912 (negative regulation of smooth muscle cell migration), GO:0014706 (striated muscle tissue development), GO:1904064 (positive regulation of cation transmembrane transport), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:0010959 (regulation of metal ion transport), GO:2001259 (positive regulation of cation channel activity), GO:0097746 (blood vessel diameter maintenance), GO:0008016 (regulation of heart contraction), GO:0050810 (regulation of steroid biosynthetic process), GO:0055007 (cardiac muscle cell differentiation), GO:0035296 (regulation of tube diameter), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:1901381 (positive regulation of potassium ion transmembrane transport), GO:0010566 (regulation of ketone biosynthetic process), GO:0010919 (regulation of inositol phosphate biosynthetic process), GO:1901018 (positive regulation of potassium ion transmembrane transporter activity), GO:0019218 (regulation of steroid metabolic process), GO:0048738 (cardiac muscle tissue development), GO:0051955 (regulation of amino acid transport), GO:0014910 (regulation of smooth muscle cell migration), GO:0055013 (cardiac muscle cell development), GO:0019220 (regulation of phosphate metabolic process), GO:0003298 (physiological muscle hypertrophy), GO:0051146 (striated muscle cell differentiation), GO:0014897 (striated muscle hypertrophy), GO:0045936 (negative regulation of phosphate metabolic process), GO:1901379 (regulation of potassium ion transmembrane transport), GO:0003300 (cardiac muscle hypertrophy), GO:0042311 (vasodilation), GO:0043266 (regulation of potassium ion transport), GO:1901016 (regulation of potassium ion transmembrane transporter activity), GO:2001257 (regulation of cation channel activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0005654 (nucleoplasm), GO:0005794 (Golgi apparatus), GO:0043233 (organelle lumen), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0042383 (sarcolemma), GO:0001669 (acrosomal vesicle), GO:0031982 (vesicle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus)