Protein: A-kinase anchoring protein 9 (A0A7P0TAD6)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
InterPro domains:
- IPR028745: A-kinase anchor protein 9/Pericentrin (family) [3-3821]
- IPR019528: Pericentrin/AKAP-450 centrosomal targeting domain (domain) [3618-3699]
- IPR005539: ELK domain (domain) [346-895]
Sequence:
MEDEERQKKLEAGKAKLESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQFHAGMRR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0016247 (channel regulator activity), GO:0005515 (protein binding), GO:0044325 (transmembrane transporter binding), GO:0099106 (ion channel regulator activity), GO:0005102 (signaling receptor binding), GO:0051018 (protein kinase A binding), GO:0015459 (potassium channel regulator activity), GO:0034237 (protein kinase A regulatory subunit binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0031503 (protein-containing complex localization), GO:0042221 (response to chemical), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0098900 (regulation of action potential), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0007165 (signal transduction), GO:0051640 (organelle localization), GO:0051651 (maintenance of location in cell), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0060306 (regulation of membrane repolarization), GO:0061842 (microtubule organizing center localization), GO:0051235 (maintenance of location), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0007017 (microtubule-based process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0044085 (cellular component biogenesis), GO:0010469 (regulation of signaling receptor activity), GO:0044057 (regulation of system process), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0034764 (positive regulation of transmembrane transport), GO:0032886 (regulation of microtubule-based process), GO:0032970 (regulation of actin filament-based process), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0099536 (synaptic signaling), GO:0002027 (regulation of heart rate), GO:0043270 (positive regulation of monoatomic ion transport), GO:0042391 (regulation of membrane potential), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0098901 (regulation of cardiac muscle cell action potential), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051642 (centrosome localization), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0032409 (regulation of transporter activity), GO:0034762 (regulation of transmembrane transport), GO:1901700 (response to oxygen-containing compound), GO:0051130 (positive regulation of cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0010033 (response to organic substance), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0051657 (maintenance of organelle location), GO:0032411 (positive regulation of transporter activity), GO:0099623 (regulation of cardiac muscle cell membrane repolarization), GO:0031323 (regulation of cellular metabolic process), GO:0099177 (regulation of trans-synaptic signaling), GO:0080090 (regulation of primary metabolic process), GO:0046683 (response to organophosphorus), GO:0043254 (regulation of protein-containing complex assembly), GO:0051246 (regulation of protein metabolic process), GO:0090257 (regulation of muscle system process), GO:1903522 (regulation of blood circulation), GO:0099601 (regulation of neurotransmitter receptor activity), GO:0022607 (cellular component assembly), GO:1902903 (regulation of supramolecular fiber organization), GO:0051591 (response to cAMP), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:1902905 (positive regulation of supramolecular fiber organization), GO:0031644 (regulation of nervous system process), GO:0043933 (protein-containing complex organization), GO:0060307 (regulation of ventricular cardiac muscle cell membrane repolarization), GO:1901701 (cellular response to oxygen-containing compound), GO:0071417 (cellular response to organonitrogen compound), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0071310 (cellular response to organic substance), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0050804 (modulation of chemical synaptic transmission), GO:0086091 (regulation of heart rate by cardiac conduction), GO:1901699 (cellular response to nitrogen compound), GO:1903115 (regulation of actin filament-based movement), GO:0031109 (microtubule polymerization or depolymerization), GO:0007020 (microtubule nucleation), GO:0034767 (positive regulation of monoatomic ion transmembrane transport), GO:0043268 (positive regulation of potassium ion transport), GO:0010243 (response to organonitrogen compound), GO:0032414 (positive regulation of ion transmembrane transporter activity), GO:0099537 (trans-synaptic signaling), GO:0051247 (positive regulation of protein metabolic process), GO:0033043 (regulation of organelle organization), GO:0022898 (regulation of transmembrane transporter activity), GO:0014070 (response to organic cyclic compound), GO:0043269 (regulation of monoatomic ion transport), GO:0006996 (organelle organization), GO:0010638 (positive regulation of organelle organization), GO:0097435 (supramolecular fiber organization), GO:0051174 (regulation of phosphorus metabolic process), GO:0031334 (positive regulation of protein-containing complex assembly), GO:0051493 (regulation of cytoskeleton organization), GO:0031116 (positive regulation of microtubule polymerization), GO:0032271 (regulation of protein polymerization), GO:0065003 (protein-containing complex assembly), GO:1904064 (positive regulation of cation transmembrane transport), GO:0031113 (regulation of microtubule polymerization), GO:0045937 (positive regulation of phosphate metabolic process), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:0010959 (regulation of metal ion transport), GO:0086004 (regulation of cardiac muscle cell contraction), GO:0007010 (cytoskeleton organization), GO:0008016 (regulation of heart contraction), GO:0098916 (anterograde trans-synaptic signaling), GO:0031110 (regulation of microtubule polymerization or depolymerization), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0031112 (positive regulation of microtubule polymerization or depolymerization), GO:1901381 (positive regulation of potassium ion transmembrane transport), GO:1903358 (regulation of Golgi organization), GO:0031401 (positive regulation of protein modification process), GO:0046785 (microtubule polymerization), GO:1901018 (positive regulation of potassium ion transmembrane transporter activity), GO:0006937 (regulation of muscle contraction), GO:0031399 (regulation of protein modification process), GO:0098962 (regulation of postsynaptic neurotransmitter receptor activity), GO:0071320 (cellular response to cAMP), GO:0071407 (cellular response to organic cyclic compound), GO:0019220 (regulation of phosphate metabolic process), GO:0014074 (response to purine-containing compound), GO:0032273 (positive regulation of protein polymerization), GO:0051495 (positive regulation of cytoskeleton organization), GO:0001932 (regulation of protein phosphorylation), GO:0061337 (cardiac conduction), GO:1901379 (regulation of potassium ion transmembrane transport), GO:0043266 (regulation of potassium ion transport), GO:0042327 (positive regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0042325 (regulation of phosphorylation), GO:0055117 (regulation of cardiac muscle contraction), GO:1901016 (regulation of potassium ion transmembrane transporter activity), GO:0007268 (chemical synaptic transmission), GO:0006942 (regulation of striated muscle contraction), GO:0051258 (protein polymerization), GO:0033138 (positive regulation of peptidyl-serine phosphorylation), GO:0033135 (regulation of peptidyl-serine phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)