Protein: Intraflagellar transport protein 121 (A0A644F0T7)
Organism: Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia)
Function: Component of the intraflagellar transport complex A (IFT-A) involved in flagellar assembly
Subcellular location: Cell projection, cilium, flagellum . Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body. Note=Localizes to the cytoplasmic and membrane-bound portions of each of the eight axonemes, localizing particularly at the flagellar pores and at the distal flagellar tips. Localizes to the basal bodies
InterPro domains:
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [3-276]
- IPR056158: IFT121, second beta-propeller domain (domain) [454-662]
- IPR056170: IFT121-like, zinc finger domain (domain) [1483-1526]
- IPR011047: Quinoprotein alcohol dehydrogenase-like superfamily (homologous_superfamily) [182-806]
- IPR057979: IFT121-like, TPR repeats (domain) [1338-1445]
- IPR056159: IFT121/TULP4, N-terminal (domain) [17-384]
Sequence:
MPSTAFILKCLEFTDTGEEVVLVAWNKTENYIAAGGQTGSIRILLLDFNSLSEQGYNISDLRTSTRNVRILMDKKLSLHDNALITSIAWNEKETKLATSDNRGLVFISSTDTGKWVRNLVNDSNRAAVVTTTWSPDASRILMVYVNGLVMLGTASGHRIYNGTINKGSAPKFGLIASNAIEVFILAWGNAICCYNFSGEEVWSVSPLLATNSDNHFVHGCWGHSSESAQLTALSPSRDPACNGSSMPQIKINSFSGDSMTLIAVTSNGMLCVYSVLTGELLSSVSTEIIPVNVQLSPGSHMLCITGSVQSSDSNFGLHQLRGNQGVSGDSTKHTAIVVVYRTADLATISRLRLPERVATSSSWDSTGLRLVLAAGKNIYIATVRPSYNHYLMNDGTMAFTMSNYTSTILSTASFVDDTQRPPMNVGALFSKKTAEEAPSSAISSFEERILDRARCNECVLFWKPGLQAPYQRWPARMIAVVGCKSYIAILTLKTNTSGTRKHHTHICFYTSVCAPIFSIDLPYVPFYTAGSGNYLVCASSSRISVVDIRGLANEAIGLVDAENVSYVYEWHADSYPLAQDRELTVARLTVNNPIVGVACCDVALFVARQDERVQRYSLPSLTLLETMTIKPNQEYMQTNCNGTVLACLHEDGSLVFYYTQSYYSEFLYAHHNPAEQQQQKQQPAPKPPQAQAHLTLLDTDADTAAALGFGQDSVVETESAPYVIKNSVLKNVNVSSGELLQDSAQARSGGVSTIPPYSPELIGIWGLVFSPEDPNLVAVSSQYKVIVFHLDTQTREDSIQTSAHIIGFSGLSIIASYLDEVSHNISSLDHAYYVLETQMLRELQEIIFGQQQAPESFNPLVDAALNRGCLNKNMISLTSDSKSGVPSSLFDSVAPKTIAIKPVRGQQPVGDMVDSGLDVTASNSSQPSTQTSQALYSKDGQISINLAGAVEYVKSHPSVHLYRIVAEASLITLRLEVASYFYIRAGDYVSYNFCESLLRLQSQDQRRAEMLMLIGNFSSAEHVYKQVLGRPDLIVKTQTDLQMWLSIIRAAKLSRTPGGNLLIDDKLLEKAHKSIGLYYMRQQQYAIASDFLQKSGDPYLYAESLFAARRYAELKALAVSLPVDEFANCIAKVAVMLARLGDVEGASEALVRVNDPHSAVHISLQLKRFDIAAAIAGKHNILHIIDRELSVYLKQLLAAGDDQGALELLRKTKQGEVIAAVIINLVLKELQTIFVNRTFPMPPGLFSKLRRIIVLAGKEATYVQREQAKKNLQAHASAAPDCMLTEQATNAAIDTFINEDDNSKAVHDVKAKNTGKEASSLEHELENAQSRLRSVPVIWRIARQTRFIVLSSYMLYIGNPEQALWPAIEAANYYHRTNDSQSSADPCIQYLSRIALPIAAQAALLFGDFELASNLLELIEADTELPASERDQLEQMSVLIYSEYNITSVPSKRKDNYQINCGHCNTLLPPYCGMCEKCHWQTPICVRTGQPIKSDKMDKTVLCQMCRSLATMGKTHLSVCPLCHEPYQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0031503 (protein-containing complex localization), GO:0007017 (microtubule-based process), GO:0042073 (intraciliary transport), GO:0007018 (microtubule-based movement), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0010970 (transport along microtubule), GO:0030030 (cell projection organization), GO:0006996 (organelle organization), GO:0099111 (microtubule-based transport), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0030990 (intraciliary transport particle)