Protein: Cytoplasmic linker associated protein 2 (A0A804HJG7)
Organism: Homo sapiens (Human)
Subcellular location: Chromosome, centromere, kinetochore. Golgi apparatus, trans-Golgi network
InterPro domains:
- IPR048491: XMAP215/Dis1/CLASP, TOG domain (domain) [50-201]
- IPR021133: HEAT, type 2 (repeat) [168-206]
- IPR011989: Armadillo-like helical (homologous_superfamily) [1-1492]
- IPR034085: TOG domain (domain) [7-1499]
- IPR016024: Armadillo-type fold (homologous_superfamily) [47-1482]
- IPR024395: CLASP N-terminal domain (domain) [321-538]
- IPR057546: Stalled ribosome sensor GCN1-like, HEAT repeats region (domain) [1269-1398]
Sequence:
MEPRSMEYFCAQVQQKDVGGRLQVGQELLLYLGAPGAISDLEEDLGRLGKTVDALTGWVGSSNYRVSLMGLEILSAFVDRLSTRFKSYVAMVIVALIDRMGDAKDKVRDEAQTLILKLMDQVAPPMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFGAQPLVISKLIPHLCILFGDSNSQVRDAAILAIVEIYRHVGEKVRMDLYKRGIPPARLEMIFAKFDEVQSSGGMILSVCKDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSSKWSTANPSTVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDKLDGTASEDGRVRAKLSAPLAGMGNAKADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKRVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQTGSGGADPTTDVSGQS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding), GO:0051010 (microtubule plus-end binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0007163 (establishment or maintenance of cell polarity), GO:0022402 (cell cycle process), GO:0051301 (cell division), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0050793 (regulation of developmental process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0040013 (negative regulation of locomotion), GO:0006903 (vesicle targeting), GO:0048523 (negative regulation of cellular process), GO:0040012 (regulation of locomotion), GO:0051640 (organelle localization), GO:0032879 (regulation of localization), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0007017 (microtubule-based process), GO:0051094 (positive regulation of developmental process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0044085 (cellular component biogenesis), GO:0051129 (negative regulation of cellular component organization), GO:0030010 (establishment of cell polarity), GO:2000145 (regulation of cell motility), GO:0051047 (positive regulation of secretion), GO:0080134 (regulation of response to stress), GO:0007051 (spindle organization), GO:0030155 (regulation of cell adhesion), GO:0032101 (regulation of response to external stimulus), GO:0060627 (regulation of vesicle-mediated transport), GO:0051648 (vesicle localization), GO:0032886 (regulation of microtubule-based process), GO:0032970 (regulation of actin filament-based process), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0010632 (regulation of epithelial cell migration), GO:0051656 (establishment of organelle localization), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:2000146 (negative regulation of cell motility), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:1903047 (mitotic cell cycle process), GO:0051649 (establishment of localization in cell), GO:0051130 (positive regulation of cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:2000147 (positive regulation of cell motility), GO:2000026 (regulation of multicellular organismal development), GO:0051653 (spindle localization), GO:0006810 (transport), GO:0044770 (cell cycle phase transition), GO:0031023 (microtubule organizing center organization), GO:0000278 (mitotic cell cycle), GO:1903035 (negative regulation of response to wounding), GO:1903532 (positive regulation of secretion by cell), GO:0032102 (negative regulation of response to external stimulus), GO:0061045 (negative regulation of wound healing), GO:0010810 (regulation of cell-substrate adhesion), GO:0043244 (regulation of protein-containing complex disassembly), GO:0031122 (cytoplasmic microtubule organization), GO:0032956 (regulation of actin cytoskeleton organization), GO:0007052 (mitotic spindle organization), GO:0051294 (establishment of spindle orientation), GO:0030334 (regulation of cell migration), GO:0150116 (regulation of cell-substrate junction organization), GO:0051650 (establishment of vesicle localization), GO:0001578 (microtubule bundle formation), GO:0022607 (cellular component assembly), GO:1902903 (regulation of supramolecular fiber organization), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:0032231 (regulation of actin filament bundle assembly), GO:0045995 (regulation of embryonic development), GO:0030335 (positive regulation of cell migration), GO:1903053 (regulation of extracellular matrix organization), GO:0043933 (protein-containing complex organization), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:1903055 (positive regulation of extracellular matrix organization), GO:1903034 (regulation of response to wounding), GO:0010256 (endomembrane system organization), GO:1901888 (regulation of cell junction assembly), GO:0140014 (mitotic nuclear division), GO:0017157 (regulation of exocytosis), GO:0030953 (astral microtubule organization), GO:1902904 (negative regulation of supramolecular fiber organization), GO:0045921 (positive regulation of exocytosis), GO:0030336 (negative regulation of cell migration), GO:0031109 (microtubule polymerization or depolymerization), GO:0007020 (microtubule nucleation), GO:0010470 (regulation of gastrulation), GO:0044772 (mitotic cell cycle phase transition), GO:0010639 (negative regulation of organelle organization), GO:1901201 (regulation of extracellular matrix assembly), GO:0043242 (negative regulation of protein-containing complex disassembly), GO:0034453 (microtubule anchoring), GO:0051293 (establishment of spindle localization), GO:0010634 (positive regulation of epithelial cell migration), GO:0033043 (regulation of organelle organization), GO:0051046 (regulation of secretion), GO:0016192 (vesicle-mediated transport), GO:0006996 (organelle organization), GO:0010717 (regulation of epithelial to mesenchymal transition), GO:0097435 (supramolecular fiber organization), GO:0051493 (regulation of cytoskeleton organization), GO:0051494 (negative regulation of cytoskeleton organization), GO:0010458 (exit from mitosis), GO:0065003 (protein-containing complex assembly), GO:0031114 (regulation of microtubule depolymerization), GO:0001952 (regulation of cell-matrix adhesion), GO:0031111 (negative regulation of microtubule polymerization or depolymerization), GO:0007010 (cytoskeleton organization), GO:0007026 (negative regulation of microtubule depolymerization), GO:0110020 (regulation of actomyosin structure organization), GO:0031110 (regulation of microtubule polymerization or depolymerization), GO:0032232 (negative regulation of actin filament bundle assembly), GO:0061041 (regulation of wound healing), GO:0046785 (microtubule polymerization), GO:0040001 (establishment of mitotic spindle localization), GO:1901879 (regulation of protein depolymerization), GO:0048285 (organelle fission), GO:1901880 (negative regulation of protein depolymerization), GO:0010715 (regulation of extracellular matrix disassembly), GO:0007030 (Golgi organization), GO:0090109 (regulation of cell-substrate junction assembly), GO:0110053 (regulation of actin filament organization), GO:0051492 (regulation of stress fiber assembly), GO:0000280 (nuclear division), GO:0051893 (regulation of focal adhesion assembly), GO:0051497 (negative regulation of stress fiber assembly), GO:0051258 (protein polymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)