Protein: Glycine receptor, alpha 4b precursor (A0A8M1P2L1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Multi- pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Synapse. Synaptic cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR006201: Neurotransmitter-gated ion-channel (family) [24-478]
- IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [47-253]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [35-252]
- IPR008127: Glycine receptor alpha (family) [40-348]
- IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [251-489]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [260-475]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [253-481]
- IPR018000: Neurotransmitter-gated ion-channel, conserved site (conserved_site) [171-185]
- IPR006028: Gamma-aminobutyric acid A receptor/Glycine receptor alpha (family) [256-478]
Sequence:
MFSVIWRILLELLLVCWMFEGVIRCVFSKELKSPSVRTKPMSPSDFLDKLMGKTSGYDARIRPNFKGPPVNVTCNIFINSFGSITETTMDYRLNVFLRQQWNDPRLAYKEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFQNGNVLYSIRLTLILSCPMDLKNFPMDTQTCTMQLESFGYTMNDLIFQWLDEGPVQVADDLMLPQFVLKEEKDLGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLTVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQYKEFFRLRRKLRQEQRNRAASGQAGAAETKNKSNNVTGGTPSRNAQRQCSACAREEQLASQNQDLYFPGFGIDTSLSGDGPLSEAAAMFAGLPPGHALFDIRRRFVEQAKRIDTISRAVFPLSFLVFNVFYWVTYKVLRNEDIHLALRP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity), GO:0005231 (excitatory extracellular ligand-gated monoatomic ion channel activity), GO:0016933 (extracellularly glycine-gated ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0048523 (negative regulation of cellular process), GO:0003008 (system process), GO:0007610 (behavior), GO:0001101 (response to acid chemical), GO:0001966 (thigmotaxis), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0048731 (system development), GO:0006810 (transport), GO:0045595 (regulation of cell differentiation), GO:1901700 (response to oxygen-containing compound), GO:0050877 (nervous system process), GO:0010033 (response to organic substance), GO:0001964 (startle response), GO:0045664 (regulation of neuron differentiation), GO:0050905 (neuromuscular process), GO:1901215 (negative regulation of neuron death), GO:0043200 (response to amino acid), GO:0007399 (nervous system development), GO:0010243 (response to organonitrogen compound), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:1901214 (regulation of neuron death), GO:0007417 (central nervous system development), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0006821 (chloride transport), GO:0042981 (regulation of apoptotic process), GO:0043524 (negative regulation of neuron apoptotic process), GO:0043066 (negative regulation of apoptotic process), GO:0043523 (regulation of neuron apoptotic process), GO:0006820 (monoatomic anion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)