Protein: Synaptojanin-1 (O18964)
Organism: Bos taurus (Bovine)
Function: Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate . Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2
Subcellular location: Cytoplasm, perinuclear region
InterPro domains:
- IPR002013: SAC domain (domain) [60-442]
- IPR000300: Inositol polyphosphate-related phosphatase (domain) [531-874]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [890-975]
- IPR015047: Synaptojanin-1/2, RNA recognition motif (domain) [867-1009]
- IPR036691: Endonuclease/exonuclease/phosphatase superfamily (homologous_superfamily) [510-889]
- IPR046985: Inositol 5-phosphatase (family) [85-1047]
- IPR034971: Synaptojanin-1, RNA recognition motif (domain) [893-969]
- IPR000504: RNA recognition motif domain (domain) [902-971]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [880-971]
Sequence:
MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAYGLLGVLRLNLGDIMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRVDSSDEDRISEVRKVLNSGNFYFAWSASGVSLDLSLNAHRSLQEHTTDNRFSWNQSLHLHLKHYGVNCADWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGIFHFDGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLTKQLEALGLAEKPQLVTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVSRTIQNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPMDIFPIGFEEMVELNAGNIVNASTTNQKLWAAELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNDDFLEIARKLSFPMGRLLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQIFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKSSLPENNFFNDALIDELLQQFTNFGEVILIRFVEDKMWVTFLEGSSALNVLNLNGKELLGRTITITLKSPDWIKTLEEEMSLEKINVPLPSSTSSTLLGEDAEVTADFDMEGDVDDYSAEVEEILPQHLQPSSSSALARPPVLHPGPVPASHLPYRRGPVPSLPVRPSRAPSRTPGPPASQSSPVDTLPATQLQQKDSSQTLEPKRPPPPRPVAPPARPAPPQRPPPPSGARSPAPARERVWSTRKAQERPRRDNLGGSQLPPQGGLPGPGLAGHSAARPIIPPRAGVISAPESHGRVSAGRLTPESQRKTXEVLKGPALLPEPLKPQAALPVPPSLAPPSQEMQEPLIAVAAPLAQSALQPSLETPPQPPPRSRSSHSLPSDAPAAAAGATIRVTGEKQTGVSAVRLDCPLKSDPFEDLSLN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0052866 (phosphatidylinositol phosphate phosphatase activity), GO:0052745 (inositol phosphate phosphatase activity), GO:0046030 (inositol trisphosphate phosphatase activity), GO:0034595 (phosphatidylinositol phosphate 5-phosphatase activity), GO:0034594 (phosphatidylinositol trisphosphate phosphatase activity), GO:0034593 (phosphatidylinositol bisphosphate phosphatase activity), GO:0106019 (phosphatidylinositol-4,5-bisphosphate phosphatase activity), GO:0004439 (phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0030258 (lipid modification), GO:0006796 (phosphate-containing compound metabolic process), GO:0046486 (glycerolipid metabolic process), GO:0006644 (phospholipid metabolic process), GO:0006650 (glycerophospholipid metabolic process), GO:0016311 (dephosphorylation), GO:0046839 (phospholipid dephosphorylation), GO:0046856 (phosphatidylinositol dephosphorylation), GO:0046488 (phosphatidylinositol metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure), GO:0048471 (perinuclear region of cytoplasm)