Protein: Sodium/hydrogen exchanger 4 (P26434)
Organism: Rattus norvegicus (Rat)
Function: Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions . As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion (By similarity). Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion (By similarity). Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids (By similarity)
Subcellular location: Basolateral cell membrane ; Multi-pass membrane protein. Apical cell membrane ; Multi-pass membrane protein . Zymogen granule membrane; Multi-pass membrane protein. Note=Enrichment at apical or basolateral membrane may be tissue-dependent
InterPro domains:
- IPR006153: Cation/H+ exchanger, transmembrane domain (domain) [77-476]
- IPR004709: Na+/H+ exchanger (family) [63-621]
- IPR032103: Sodium/hydrogen exchanger, regulatory region (domain) [566-673]
- IPR001953: Sodium/hydrogen exchanger 2/4 (family) [115-627]
- IPR018422: Cation/H+ exchanger, CPA1 family (family) [45-620]
Sequence:
MGPAMLRAFSSWKWLLLLMVLTCLEASSYVNESSSPTGQQTPDARFAASSSDPDERISVFELDYDYVQIPYEVTLWILLASLAKIGFHLYHRLPHLMPESCLLIIVGALVGSIIFGTHHKSPPVMDSSIYFLYLLPPIVLESGYFMPTRPFFENIGSILWWAGLGALINAFGIGLSLYFICQIKAFGLGDINLLQNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMIFGEALLNDGISVVLYNILIAFTKMHKFEDIEAVDILAGCARFVIVGCGGVFFGIIFGFISAFITRFTQNISAIEPLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCQIWRAISVFTLFYVSNQFRTFPFSIKDQLIIFYSGVRGAGSFSLAFLLPLTLFPRKKLFVTATLVVTYFTVFFQGITIGPLVRYLDVRKTNKKESINEELHIRLMDHLKAGIEDVCGQWSHYQVRDKFKKFDHRYLRKILIRRNQPKSSIVSLYKKLEMKQAIEMAETGLLSSVASPTPYQSERIQGIKRLSPEDVESMRDILTRNMYQVRQRTLSYNKYNLKPQTSEKQAKEILIRRQNTLRESLRKGQSLPWVKPAGTKNFRYLSFPYSNPQPARRGARAAESTGNPCCWLLHFLLCRAMVEKIWGPGGQETQPRLLCRNLN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0015078 (proton transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0140828 (metal cation:monoatomic cation antiporter activity), GO:0015385 (sodium:proton antiporter activity), GO:0051139 (metal cation:proton antiporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0055085 (transmembrane transport), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0021700 (developmental maturation), GO:0140352 (export from cell), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0048731 (system development), GO:0006810 (transport), GO:0140115 (export across plasma membrane), GO:0016043 (cellular component organization), GO:0034220 (monoatomic ion transmembrane transport), GO:0071695 (anatomical structure maturation), GO:0098655 (monoatomic cation transmembrane transport), GO:0022008 (neurogenesis), GO:0098662 (inorganic cation transmembrane transport), GO:0071705 (nitrogen compound transport), GO:0007399 (nervous system development), GO:0002064 (epithelial cell development), GO:0046903 (secretion), GO:0016192 (vesicle-mediated transport), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0061024 (membrane organization), GO:0071805 (potassium ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0006897 (endocytosis), GO:0048699 (generation of neurons), GO:0007009 (plasma membrane organization), GO:0045055 (regulated exocytosis), GO:0030001 (metal ion transport), GO:0006813 (potassium ion transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045177 (apical part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane)