Protein: DASH complex subunit DAD1 (G0RYE9)
Organism: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
Function: Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle
Subcellular location: Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Nucleus
InterPro domains:
- IPR013958: DASH complex subunit Dad1 (family) [2-93]
Sequence:
MAAHKRSTSAVPGTREMSYFEQQRQALIEEIAMNFEHVLANINKLNRSLEAVIAVGNEFSSVEALWSQFENVMAKAPEEEANAKAGEEQEGDGNAGAGDRGANDAGQV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0022402 (cell cycle process), GO:0050794 (regulation of cellular process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0051640 (organelle localization), GO:0048522 (positive regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0007059 (chromosome segregation), GO:1903047 (mitotic cell cycle process), GO:0051656 (establishment of organelle localization), GO:0050000 (chromosome localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0045787 (positive regulation of cell cycle), GO:0098813 (nuclear chromosome segregation), GO:0140014 (mitotic nuclear division), GO:0007080 (mitotic metaphase plate congression), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0000070 (mitotic sister chromatid segregation), GO:0051303 (establishment of chromosome localization), GO:0051310 (metaphase plate congression), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0000280 (nuclear division)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0019954 (asexual reproduction), GO:0048569 (post-embryonic animal organ development), GO:0043228 (non-membrane-bounded organelle), GO:0000779 (condensed chromosome, centromeric region), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005694 (chromosome), GO:0000793 (condensed chromosome)