Protein: Thrombospondin 1 (A6HP99)
Organism: Rattus norvegicus (Rat)
Subcellular location: Secreted
InterPro domains:
- IPR024731: NELL2-like, EGF domain (domain) [592-631]
- IPR001007: VWFC domain (domain) [316-373]
- IPR000742: EGF-like domain (domain) [489-632]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [29-233]
- IPR048287: Thrombospondin-like, N-terminal domain (domain) [24-221]
- IPR036383: Thrombospondin type-1 repeat superfamily (homologous_superfamily) [376-488]
- IPR017897: Thrombospondin, type 3 repeat (repeat) [669-704]
- IPR003367: Thrombospondin, type 3-like repeat (repeat) [669-746]
- IPR001791: Laminin G domain (domain) [101-217]
- IPR028974: TSP type-3 repeat (homologous_superfamily) [633-748]
- IPR000884: Thrombospondin type-1 (TSP1) repeat (repeat) [377-489]
- IPR001881: EGF-like calcium-binding domain (domain) [484-587]
Sequence:
MELLRGLGVLFLLHVCGSNRIPESGGDNGVFDIFELIGGARKVPGRRLVKGQDLSSPAFRIENANLIPPVPDDKFQDLLDAVWADKGFIFLASLRQMKKTRGTLLAVERKDNSGQIFSVVSNGKAGTLDLSLSLPGKQQVVSVEEALLATGQWKSITLFVQEDRAQLYIDCDKMESAELDVPIQSIFTRDLANVARLRVAKGDVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTNVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGLSCDELSSMVLELRGLRTIVTTLQDSIRKVTEENRELASELRRPPLCFHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWLKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWSPWSLWDICSVTCGGGVQRRSRLCNNPTPQFGGKDCVGDVTENQVCNKQDCPIDGCLSNPCFAGAKCTSYPDGSWKCGACPPGYSGNGIQCKDVDECKEVPDACFNHNGEHRCKNTDPGYNCLPCPPRFTGSQPFGRGVEHAMANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACAVDIDGDAGL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019838 (growth factor binding), GO:0019955 (cytokine binding), GO:0050431 (transforming growth factor beta binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0050793 (regulation of developmental process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:2000026 (regulation of multicellular organismal development), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0070848 (response to growth factor), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0001819 (positive regulation of cytokine production), GO:0009612 (response to mechanical stimulus), GO:0001817 (regulation of cytokine production), GO:1901343 (negative regulation of vasculature development), GO:0010033 (response to organic substance), GO:0034097 (response to cytokine), GO:1901654 (response to ketone), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:1901342 (regulation of vasculature development), GO:0071636 (positive regulation of transforming growth factor beta production), GO:0010628 (positive regulation of gene expression), GO:0045765 (regulation of angiogenesis), GO:0014070 (response to organic cyclic compound), GO:0071363 (cellular response to growth factor stimulus), GO:0010468 (regulation of gene expression), GO:0071634 (regulation of transforming growth factor beta production), GO:2000181 (negative regulation of blood vessel morphogenesis), GO:0016525 (negative regulation of angiogenesis), GO:0034612 (response to tumor necrosis factor), GO:0033574 (response to testosterone), GO:0071345 (cellular response to cytokine stimulus), GO:0071356 (cellular response to tumor necrosis factor)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure), GO:0005576 (extracellular region), GO:0005615 (extracellular space)