Protein: receptor protein-tyrosine kinase (A0A9K3Y730)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single- pass type I membrane protein
InterPro domains:
- IPR002011: Tyrosine-protein kinase, receptor class II, conserved site (conserved_site) [733-741]
- IPR050122: Receptor Tyrosine Kinase (family) [360-848]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [705-717]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [564-845]
- IPR000719: Protein kinase domain (domain) [563-848]
- IPR048525: Discoidin domain-containing receptor 1/2, DS-like domain (domain) [190-366]
- IPR008979: Galactose-binding-like domain superfamily (homologous_superfamily) [29-187]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [563-848]
- IPR000421: Coagulation factor 5/8, C-terminal domain (domain) [29-185]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [552-845]
Sequence:
MILIPRMPLVLLLLLLILGSAKAQVNPAICRYPLGMSGGHIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVQPDDLKEFLQIDLRTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGNRWISWRNRHGKQVLDGNSNPYDVFLKDLEPPIVARFVRLIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGFIEIMFEFDRVRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSETSEWEPTAVYFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSGALPTSPMAPTTFDPMLKVDDSNTRILIGCLVAIIFILLAVIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSESSMFNNNHSSSPSEQESNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPAQPNGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDANIIRLLAVCITEDPLCMITEYMENGDLNQFLSRHEPLSSGSSNATVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLPQPAVCPDSVYKLMLSCWRRETKHRPSFQEIHLLLLQQGAE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005518 (collagen binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0040012 (regulation of locomotion), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0001666 (response to hypoxia), GO:0010942 (positive regulation of cell death), GO:0090068 (positive regulation of cell cycle process), GO:2000145 (regulation of cell motility), GO:0060548 (negative regulation of cell death), GO:0080134 (regulation of response to stress), GO:0070482 (response to oxygen levels), GO:0010714 (positive regulation of collagen metabolic process), GO:0070848 (response to growth factor), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0010712 (regulation of collagen metabolic process), GO:0009725 (response to hormone), GO:0045787 (positive regulation of cell cycle), GO:0051726 (regulation of cell cycle), GO:0010564 (regulation of cell cycle process), GO:0050865 (regulation of cell activation), GO:0008284 (positive regulation of cell population proliferation), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0044092 (negative regulation of molecular function), GO:0080135 (regulation of cellular response to stress), GO:1901700 (response to oxygen-containing compound), GO:0031324 (negative regulation of cellular metabolic process), GO:1903036 (positive regulation of response to wounding), GO:0010033 (response to organic substance), GO:2000147 (positive regulation of cell motility), GO:0009891 (positive regulation of biosynthetic process), GO:0050867 (positive regulation of cell activation), GO:1902883 (negative regulation of response to oxidative stress), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0009612 (response to mechanical stimulus), GO:1901652 (response to peptide), GO:0032967 (positive regulation of collagen biosynthetic process), GO:0007346 (regulation of mitotic cell cycle), GO:0048145 (regulation of fibroblast proliferation), GO:0071453 (cellular response to oxygen levels), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0060547 (negative regulation of necrotic cell death), GO:1901032 (negative regulation of response to reactive oxygen species), GO:0030334 (regulation of cell migration), GO:0048660 (regulation of smooth muscle cell proliferation), GO:1900407 (regulation of cellular response to oxidative stress), GO:1903201 (regulation of oxidative stress-induced cell death), GO:0036293 (response to decreased oxygen levels), GO:1902882 (regulation of response to oxidative stress), GO:0090303 (positive regulation of wound healing), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0030335 (positive regulation of cell migration), GO:1902533 (positive regulation of intracellular signal transduction), GO:0048146 (positive regulation of fibroblast proliferation), GO:1901701 (cellular response to oxygen-containing compound), GO:1901216 (positive regulation of neuron death), GO:0071456 (cellular response to hypoxia), GO:0071417 (cellular response to organonitrogen compound), GO:0071559 (response to transforming growth factor beta), GO:0043086 (negative regulation of catalytic activity), GO:1901989 (positive regulation of cell cycle phase transition), GO:1903034 (regulation of response to wounding), GO:0071310 (cellular response to organic substance), GO:1901699 (cellular response to nitrogen compound), GO:0048661 (positive regulation of smooth muscle cell proliferation), GO:1901214 (regulation of neuron death), GO:0045931 (positive regulation of mitotic cell cycle), GO:1903202 (negative regulation of oxidative stress-induced cell death), GO:0010939 (regulation of necrotic cell death), GO:0043434 (response to peptide hormone), GO:0032870 (cellular response to hormone stimulus), GO:0032965 (regulation of collagen biosynthetic process), GO:0010243 (response to organonitrogen compound), GO:0035994 (response to muscle stretch), GO:1901987 (regulation of cell cycle phase transition), GO:0051338 (regulation of transferase activity), GO:0071363 (cellular response to growth factor stimulus), GO:0051174 (regulation of phosphorus metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0042981 (regulation of apoptotic process), GO:1904705 (regulation of vascular associated smooth muscle cell proliferation), GO:1901031 (regulation of response to reactive oxygen species), GO:1902808 (positive regulation of cell cycle G1/S phase transition), GO:0043549 (regulation of kinase activity), GO:1901992 (positive regulation of mitotic cell cycle phase transition), GO:0051348 (negative regulation of transferase activity), GO:0043410 (positive regulation of MAPK cascade), GO:1903205 (regulation of hydrogen peroxide-induced cell death), GO:0061041 (regulation of wound healing), GO:0014911 (positive regulation of smooth muscle cell migration), GO:0043408 (regulation of MAPK cascade), GO:0071560 (cellular response to transforming growth factor beta stimulus), GO:0071375 (cellular response to peptide hormone stimulus), GO:0043066 (negative regulation of apoptotic process), GO:0014910 (regulation of smooth muscle cell migration), GO:1903206 (negative regulation of hydrogen peroxide-induced cell death), GO:0019220 (regulation of phosphate metabolic process), GO:1901653 (cellular response to peptide), GO:0036294 (cellular response to decreased oxygen levels), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:1904707 (positive regulation of vascular associated smooth muscle cell proliferation), GO:1990776 (response to angiotensin), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:0045936 (negative regulation of phosphate metabolic process), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0042326 (negative regulation of phosphorylation), GO:1904385 (cellular response to angiotensin), GO:1900087 (positive regulation of G1/S transition of mitotic cell cycle), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0042325 (regulation of phosphorylation), GO:0033673 (negative regulation of kinase activity), GO:2000045 (regulation of G1/S transition of mitotic cell cycle), GO:1904752 (regulation of vascular associated smooth muscle cell migration), GO:1904754 (positive regulation of vascular associated smooth muscle cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045177 (apical part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane)