lokahq/bioreason-rl huggingface dataset:
Protein: Band 4.1-like protein 3 isoform X7 (A0A8M9P5V2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR018980: FERM, C-terminal PH-like domain (domain) [211-301]
- IPR030691: Band 4.1-like protein 3, FERM domain, F1 sub-domain (domain) [1-83]
- IPR019748: FERM central domain (domain) [84-192]
- IPR008379: Band 4.1, C-terminal (domain) [790-895]
- IPR000798: Ezrin/radixin/moesin-like (family) [14-230]
- IPR007477: SAB domain (domain) [476-523]
- IPR000299: FERM domain (domain) [1-297]
- IPR019749: Band 4.1 domain (domain) [1-192]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [1-81]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [79-186]
- IPR014847: FERM adjacent (domain) [303-349]
- IPR035963: FERM superfamily, second domain (homologous_superfamily) [83-187]
- IPR018979: FERM, N-terminal (domain) [5-67]
- IPR019747: FERM conserved site (conserved_site) [55-191]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [187-296]
Sequence:
MQCKITLLDGSDYTCVVEKRDKGQVLFDKVCEHLNLLEKDYFGITFRDVENQKNWLDPAKDMKKQIRGVAWNFSFNVKFYPPEPALLSEDITRYYLCLQLRDDISSGRLPCSFATHTVLGSYTVQSELGDHDPEECGSEYTSEFRFAPQQTKEMEEKIIDLHKNYKGMTPAEAEMHFLENVKKLSMYGVDLHHAKLIGRFFHCFSPAKGEDSEGVEIMLGVCSSGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLVLPETPPKKFLTLGSKFRYSGRTQAQTRRASSQIVRPAPYFQRSSSKRYTMSRSLDGEMGTALYGAAKGIAMSDLITTVTPEKKVEEEPQPQKHTHADKQMQPQTETETETDTHTQTQTVLVENVMILEDDDETTRATELSLPSPATPARLDTRTDLTDTAVDGELTATESDQEDESEAKTKEADLTPDEQLKPQTNISELKRTFLEGGAEPAGLTEWEKRLSSSPLRSPRREEPPMIEPLELDEIKQEVVVETQEVAETQEVAAALDTQENNRKVDEPKPSFEEMSPELTALLQSARSWTPVPASASPSASASALVTPAPAALHTPQNQPSESVDEHLGKGLTEEERPADEPLDKPQVPAPPAGPLEPDGYYQACVACVEPLSSVRALDESESDGDSSDSSSVNSTNLDGPLERVAPQRAESPSESESEGESFTLSTDDEDDDGDRSPNISLSEQRGVAEGHSGEVDLMAGVETGVLSFRSVSGDTHDTHETHDTPVIQTEIKTITYEALQAETDGDADPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVISGDADIDHDEALAQAIKEAKEQHPDMSVTKVVVHKETEITPEEAEE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0044087 (regulation of cellular component biogenesis), GO:0050807 (regulation of synapse organization), GO:1901888 (regulation of cell junction assembly), GO:0051963 (regulation of synapse assembly), GO:1904889 (regulation of excitatory synapse assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0019898 (extrinsic component of membrane), GO:0005886 (plasma membrane), GO:0019897 (extrinsic component of plasma membrane)
Protein: RNA helicase (A0A8M9QFJ5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm
InterPro domains:
- IPR001650: Helicase, C-terminal domain-like (domain) [466-627]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [187-632]
- IPR011545: DEAD/DEAH-box helicase domain (domain) [251-442]
- IPR014014: RNA helicase, DEAD-box type, Q motif (domain) [227-255]
- IPR000629: ATP-dependent RNA helicase DEAD-box, conserved site (conserved_site) [397-405]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [246-470]
Sequence:
MSHVVVDGSHGLDQQLAVLDLNSADGQGVGTGPGNAYSSGRQSGYSVAPVQSYSPGWDGSRTNGFVNGYHDSRMNGTANFARGPLRNDRGGRGGFRGNRNGASFNQPVHNAGYGTYENKDGGWNSVVNRDAYASFGGRSDRGKSAFFNDRGASSRGRYERGGFGGGTGGNSRWVEESRDEEDWSKPMPPNERLEHELFSASNTGINFEKYDDIPVEATGTNSPGHIESFHDVDMGEIIMGNITLSRYTRPTPVQKYAIPIIKTKRDLMACAQTGSGKTAAFLLPVLSQIYSEGPGEALQATKASTQQENGKYVRRKQYPISLVLAPTRELALQIYDEARKFAYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGSRQTMMFSATFPKEIQILARDFLEEYIFLAVGRVGSTSENITQKVVWVEENDKRSFLLDLLNATGKDSLTLVFVETKKGADALEDFLYREGYACTSIHGDRSQRDREEALHQFRSGRCPIMVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFYNDKNSNITKDLLDILVEAKQEVPSWLENLAYEHQHKSTNRGRPKRFSGGFGARDYRQMPGGGNTFGNRGARNTGGHGGNRGFGGNKGGFGSFGGDSYGGTYGNYGGNYTQVDWWGN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0050900 (leukocyte migration), GO:0042330 (taxis), GO:0097529 (myeloid leukocyte migration), GO:0006935 (chemotaxis), GO:0030595 (leukocyte chemotaxis), GO:0070887 (cellular response to chemical stimulus), GO:0016477 (cell migration), GO:0071621 (granulocyte chemotaxis), GO:0060326 (cell chemotaxis), GO:0097530 (granulocyte migration), GO:1990266 (neutrophil migration), GO:0030593 (neutrophil chemotaxis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0043229 (intracellular organelle), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0045495 (pole plasm), GO:0043228 (non-membrane-bounded organelle), GO:0043186 (P granule), GO:0060293 (germ plasm), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: non-specific serine/threonine protein kinase (A0A8M2BI44)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR051931: Serine/threonine-protein kinase PAK 3-like (family) [68-512]
- IPR033923: p21 activated kinase binding domain (domain) [56-101]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [360-372]
- IPR000719: Protein kinase domain (domain) [245-496]
- IPR000095: CRIB domain (domain) [57-114]
- IPR017441: Protein kinase, ATP binding site (binding_site) [251-274]
- IPR035064: p21-activated kinase 2, catalytic domain (domain) [225-520]
- IPR036936: CRIB domain superfamily (homologous_superfamily) [53-131]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [235-498]
Sequence:
MSSTIFSGAKDHALTANHSSKPLPSVPEERKRNKIYSIFSGAEKGGRRKDRDKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLKFYDSTGNGRQKYLSFSSEKDSFPSGEQSPAKKTPEPSSPVKAVDDEDNGEDEDDDDDEETPPPVVAPRPEHTKSVYTRPSVIDPLPPPVTSPESDAASKATDRQRPKKGKMTDEEIMDKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVGEELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQSPEKLSPIFRDFLGRCLEMDVEKRGGSKELLQHPFLKLAKPLSSLTPLILAAKDAMKNNR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Cytohesin-1 isoform X1 (A0A8M6Z459)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR001849: Pleckstrin homology domain (domain) [283-400]
- IPR035999: Sec7 domain superfamily (homologous_superfamily) [82-275]
- IPR023394: Sec7, C-terminal domain superfamily (homologous_superfamily) [159-282]
- IPR000904: Sec7 domain (domain) [78-267]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [283-409]
Sequence:
MDSQVMGTVSDLCVSSFQAFLCPTIPRSPPVPDDLTPEEQKELENIRRRKQELLDDIQRLKDEIAEVTSEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTSEDIARFLYKGEGLNKTAIGDYLGERDDFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNPGVFQSTDTCYILSFAIIMLNTSLHNPNVKDKPTVERFISMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDKKPNCFELFIPDNKDQVIKACKTEADGRVVEGNHTFYRISAPTTEEKDEWMNSIKAAISRDPFYEMLAARKKKVSSMKRH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0007369 (gastrulation), GO:0002009 (morphogenesis of an epithelium), GO:0055113 (epiboly involved in gastrulation with mouth forming second), GO:0060429 (epithelium development), GO:0002011 (morphogenesis of an epithelial sheet), GO:0001702 (gastrulation with mouth forming second), GO:0090504 (epiboly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Neuromedin-U isoform X3 (A0A8M9PBN3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR042384: Neuromedin-U (family) [1-119]
- IPR008200: Neuromedin U, C-terminal (domain) [117-141]
Sequence:
MRNSNQCERATAHSAMSPGNTSALMLAVLLLSFIPITTSAPMLLNPSSLEHEQLLTQITDLCSFYLSADPSFRTSDVLEDLCFLMLGSLQKSKEITARETSKRFLFHYTKPNGAGLSDGTENLQGPGRIQSRGYFLYRPRNGRRSDEYV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0001664 (G protein-coupled receptor binding), GO:0071855 (neuropeptide receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0048511 (rhythmic process), GO:0007610 (behavior), GO:0007623 (circadian rhythm), GO:0007622 (rhythmic behavior), GO:0048512 (circadian behavior)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098793 (presynapse), GO:0150034 (distal axon), GO:0044306 (neuron projection terminus), GO:0042995 (cell projection), GO:0030054 (cell junction), GO:0045202 (synapse), GO:0120025 (plasma membrane bounded cell projection), GO:0043679 (axon terminus), GO:0043195 (terminal bouton), GO:0043005 (neuron projection), GO:0030424 (axon)
Protein: Myelin protein P0 isoform X3 (A0A8M6Z0S2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR013106: Immunoglobulin V-set domain (domain) [28-138]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [22-145]
- IPR000920: Myelin P0 protein-related (family) [7-198]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [29-127]
- IPR007110: Immunoglobulin-like domain (domain) [20-137]
- IPR047014: Myelin P0 protein, Ig-like domain (domain) [22-138]
- IPR003599: Immunoglobulin domain subtype (domain) [27-139]
Sequence:
MLSVLALTSVVLLGIASQSTALVVNTDSEKHALVGSDVRLSCSFFSWQWTSPEVSFTWHYRPDGAKDAISIFHYGGGEAYPANKGPFQNRLEFVGNPSRRDGSILIKNLDFGDNGTFTCDAKNPPDIGGHPSTIRLLVFEKVPVQAGVITGSIIGVVLGLLILVVAIYYLMRFLVARRVFSLSMSKHGKKGKGKEGSQQKQAGPQK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0007155 (cell adhesion), GO:0098609 (cell-cell adhesion), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046649 (lymphocyte activation), GO:0030097 (hemopoiesis), GO:0042110 (T cell activation), GO:0002521 (leukocyte differentiation), GO:0030098 (lymphocyte differentiation), GO:1903131 (mononuclear cell differentiation), GO:0030217 (T cell differentiation), GO:0033077 (T cell differentiation in thymus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043209 (myelin sheath)
Protein: Microtubule-associated protein RP/EB family member 2 (A0A8M2BA49)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton
InterPro domains:
- IPR027328: Microtubule-associated protein RP/EB (family) [1-280]
- IPR004953: EB1, C-terminal (domain) [200-270]
- IPR036872: CH domain superfamily (homologous_superfamily) [1-130]
- IPR036133: EB1, C-terminal domain superfamily (homologous_superfamily) [207-267]
- IPR001715: Calponin homology domain (domain) [14-117]
Sequence:
MAVNVYSTSITQETMSRHDITAWVNDLLCLNYTKVEQLSSGAAYCQFMDMLFPGCISLKKVKFQAKLEHEYIHNFKLLQASFKRMNVDKIIPVEKLVKGRFQDNLDFIQWFKKFFDANYDGKEYDPVEARQGQDAIPPPDPGEQIFNLPKKSHHAASSPTAGATRSTSSTPKSSTSTSTSTSRPSSAKKLPVMSATPAKGEKELEAQVTQLNEQMNTLKLALEGVEKERDFYFGKLREVELLCQEQGQDNGPFVERLMEVLYSADDQEAGGEEHEAPAQEEDVPDDTQDEY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:1904888 (cranial skeletal system development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005911 (cell-cell junction), GO:0005912 (adherens junction)
Protein: Band 4.1-like protein 3 isoform X1 (A0A8M9P5U6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR018980: FERM, C-terminal PH-like domain (domain) [211-301]
- IPR030691: Band 4.1-like protein 3, FERM domain, F1 sub-domain (domain) [1-83]
- IPR019748: FERM central domain (domain) [84-192]
- IPR008379: Band 4.1, C-terminal (domain) [975-1080]
- IPR000798: Ezrin/radixin/moesin-like (family) [14-230]
- IPR007477: SAB domain (domain) [476-523]
- IPR000299: FERM domain (domain) [1-297]
- IPR019749: Band 4.1 domain (domain) [1-192]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [1-81]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [79-186]
- IPR014847: FERM adjacent (domain) [303-349]
- IPR035963: FERM superfamily, second domain (homologous_superfamily) [83-187]
- IPR018979: FERM, N-terminal (domain) [5-67]
- IPR019747: FERM conserved site (conserved_site) [55-191]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [187-296]
Sequence:
MQCKITLLDGSDYTCVVEKRDKGQVLFDKVCEHLNLLEKDYFGITFRDVENQKNWLDPAKDMKKQIRGVAWNFSFNVKFYPPEPALLSEDITRYYLCLQLRDDISSGRLPCSFATHTVLGSYTVQSELGDHDPEECGSEYTSEFRFAPQQTKEMEEKIIDLHKNYKGMTPAEAEMHFLENVKKLSMYGVDLHHAKLIGRFFHCFSPAKGEDSEGVEIMLGVCSSGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLVLPETPPKKFLTLGSKFRYSGRTQAQTRRASSQIVRPAPYFQRSSSKRYTMSRSLDGEMGTALYGAAKGIAMSDLITTVTPEKKVEEEPQPQKHTHADKQMQPQTETETETDTHTQTQTVLVENVMILEDDDETTRATELSLPSPATPARLDTRTDLTDTAVDGELTATESDQEDESEAKTKEADLTPDEQLKPQTNISELKRTFLEGGAEPAGLTEWEKRLSSSPLRSPRREEPPMIEPLELDEIKQEVVVETQEVAETQEVAAALDTQENNRKVDEESDGWVIINKVPPFEAHKAPVETRDKSSIQPEIIVQDASPPAEPMKEFPEDVPAEKMDPEKTTKDEAPPEKTTVEEALPEKTTVDEALPEKTTVDETPLEKTIEKTTVDETPPEKIHSEKTEDVPPKVPPKVPPKVPEKKHSSSYRFLSSMSSAPPPSSVRPRSEDLSAGRISPALLRTSPTAKVPKPSFEEMSPELTALLQSARSWTPVPASASPSASASALVTPAPAALHTPQNQPSESVDEHLGKGLTEEERPADEPLDKPQVPAPPAGPLEPDGYYQACVACVEPLSSVRALDESESDGDSSDSSSVNSTNLDGPLERVAPQRAESPSESESEGESFTLSTDDEDDDGDRSPNISLSEQRGVAEGHSGEVDLMAGVETGVLSFRSVSGDTHDTHETHDTPVIQTEIKTITYEALQAETDGDADPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVISGDADIDHDEALAQAIKEAKEQHPDMSVTKVVVHKETEITPEEAEE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0044087 (regulation of cellular component biogenesis), GO:0050807 (regulation of synapse organization), GO:1901888 (regulation of cell junction assembly), GO:0051963 (regulation of synapse assembly), GO:1904889 (regulation of excitatory synapse assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0019898 (extrinsic component of membrane), GO:0005886 (plasma membrane), GO:0019897 (extrinsic component of plasma membrane)
Protein: Rho guanine nucleotide exchange factor 3 (A0A8M2B905)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases
Subcellular location: Cytoplasm
InterPro domains:
- IPR000219: Dbl homology domain (domain) [155-337]
- IPR001849: Pleckstrin homology domain (domain) [328-484]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [137-352]
- IPR055251: SOS1/NGEF-like, PH domain (domain) [366-479]
- IPR044129: Rho guanine nucleotide exchange factor 3, PH domain (domain) [349-481]
- IPR051480: Endocytic & GEF Adapter (family) [35-515]
- IPR001331: Guanine-nucleotide dissociation stimulator, CDC24, conserved site (conserved_site) [285-310]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [353-487]
Sequence:
MVDLCCLDINSSMSAGGDEASGPMVQGKESFSLLSTSEKWLFKGKKRKQRKRDVDSLSLCSLDINEPSTKRVKPLSRVTSLASLIPPVKAAPLKRIGQTLQRSISFRSDCRPEIMAPRPWSRQVVPTITKRRDSKLWSETFDVGLGHMLSSKEIKRQEAIFELSQGEQDLIEDLKLAKKAYHDPMLKLCIMTEHELNQIFGTLDSLIPLHEDLLSRLRDVRNPDGSTDHMGHILVHWLPCLETYNSYCSNQVAAKALLDHKKQDHRVHDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILKHTPNEHPDRQHLDEAINMIQSIVAGINTQTGESECRYYKERLLYLESGQRDLLIESSRILICHGELKNNRGVKLHVFLFQDVLVITRAISHNEQLWYQLYRQPIPVRDLEWEDLQDGEMRVGGSIRGAFSNNERTKNFFRVMFRCGGQTQMHCFQASDTFNKQQWLNCIRQAKEAVGSAESEPPRSPQMDRERQHNDCSDSNMMDTMEDSSSEYPQMELADIPVSPVRE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0003712 (transcription coregulator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0019207 (kinase regulator activity), GO:0003713 (transcription coactivator activity), GO:0008047 (enzyme activator activity), GO:0030695 (GTPase regulator activity), GO:0019209 (kinase activator activity), GO:0019887 (protein kinase regulator activity), GO:0030295 (protein kinase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048856 (anatomical structure development), GO:0048869 (cellular developmental process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis), GO:0030099 (myeloid cell differentiation), GO:0061515 (myeloid cell development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)