Protein: EF-hand domain-containing family member B (Q8N7U6)
Organism: Homo sapiens (Human)
Function: Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion and the activation of store- operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, cilium axoneme
InterPro domains:
- IPR011992: EF-hand domain pair (homologous_superfamily) [554-817]
- IPR040193: EF-hand domain-containing protein EFHC1/EFHC2/EFHB (family) [247-831]
- IPR057428: EFHB, C-terminal EF-hand domain (domain) [750-823]
- IPR002048: EF-hand domain (domain) [561-632]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [610-622]
Sequence:
MNMEIGHPHEGKDDLGDKRVIMGTKFPMELGIRVGLGKEDSRCGESPVVSNKCEGRMAPPETKFPLSKGLEMGLERQNISRTVMQRGSLGVDSVSASQGTKPSLLPGRMGLENESLLAGYTHERIIQPPLGRVCGSSQAAGSRRAPLASGPEGVEELVGKPAFVMEPRQEMEKESTCVLMKPNTEIKLPVEVDIGLTQAEGPDETKNTEPQMGLVIEPPQCQFAQQHEQRKEAGNIESGVEPPDRIRPIYSGKFFDRTPCWPSAGKVIPVGYRVATCLTEKLPRLITPPEAKKYFNFRYPPAGVERVFYGRANDPQIAPYLTHGIRSKISVLANTLINPQPITTFQQKIKDKKESIYLSNRRAPLGKSHDQAPGLPKGMDTTNTTFGTAVIKEYSAKDVVNPPKSYEEVFKEGNEGHDLYVVSHNDYYAGEAKNRKYNPSSFHRCSVYGVPTPHFNDGRAMAKSLYWLHELQMKRGAKFVSKRADDFKEKFQHKLGRVLDPIAETMNVPPDCTFGACLRPEEYGVGDLIHNRLPDEYLRGKDRQRALIAAVRHHLKKVNYQKFDTLLAAFRHYDKKGDGMIDKDELQEACDQANLSLDDKLLDQLFDYCDVDNDGFINYLEFANFLNWKDKMLLKEYEERVIIKGRKPDCVNPTEANVEEPEQTLLIKPEDIVLKEAGSTEKTLRTLLRPSDKVSNYYKTTSSEINAIVGAIPSTCYPICGVPTIRSDIPAPRIRRISDRTNYGEEGSAYSLLYPTIFARKGVFERDFFKTRSKEEIAEILCNIGVKLSDEEFENVWNLASKKHHRGEVCVENIRNVLDELRHADRIKCKTLM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140299 (small molecule sensor activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051049 (regulation of transport), GO:0051098 (regulation of binding), GO:0010646 (regulation of cell communication), GO:0044092 (negative regulation of molecular function), GO:0009966 (regulation of signal transduction), GO:0043269 (regulation of monoatomic ion transport), GO:0043393 (regulation of protein binding), GO:0051100 (negative regulation of binding), GO:1902531 (regulation of intracellular signal transduction), GO:0050848 (regulation of calcium-mediated signaling), GO:0010959 (regulation of metal ion transport), GO:0032091 (negative regulation of protein binding), GO:0051924 (regulation of calcium ion transport), GO:0106056 (regulation of calcineurin-mediated signaling), GO:0070884 (regulation of calcineurin-NFAT signaling cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0036064 (ciliary basal body), GO:0005881 (cytoplasmic microtubule), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043228 (non-membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0005879 (axonemal microtubule), GO:0043227 (membrane-bounded organelle), GO:0005929 (cilium), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0099513 (polymeric cytoskeletal fiber), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)