Protein: Toll-like receptor 2 (A0A8K0ZGH5)
Organism: Rattus norvegicus (Rat)
Function: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response
Subcellular location: Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR017241: Toll-like receptor (family) [2-784]
- IPR035897: Toll/interleukin-1 receptor homology (TIR) domain superfamily (homologous_superfamily) [637-784]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [50-499]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [24-590]
- IPR000157: Toll/interleukin-1 receptor homology (TIR) domain (domain) [639-784]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [533-586]
- IPR001611: Leucine-rich repeat (repeat) [77-535]
Sequence:
MLQALWLFWILMAVIGLSREGHSAQASLSCDAAGVCDGSSRSFTSIPSGLTANTKKLDLSFNKITYIGHGDLRACVNLRVLTLESSGINTIEGDAFYSLGSLEHLDLSNNHLSSLSSSWFRPLSSLKYLNLMGNPYRTLGETSLFSNLTNLQTLRVGNVDTFSEIRRIDFAGLTSLNELEIQVLSLGNYESRSLQSIRDIYHLTLHLSESAFLLGIFADILSSVRYLELRDTNLARFQFSELSVDEINSPMKKLAFRNADLTDKSFNELLKLLRYILELMEVEFDHCTLNGVGNFNPSESDVVRELGKVETVTIRSLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACEGGWPSLQSLVLSQNHLRSIRKTAEILLTLKNLTALDISKNSFQPMPDSCQWPGKMRFLNLSSTGIQAVKTCIPQTLEVLDVSNNNLDSFSLFLPRLQELYISRNKLKTLPEASLFPVLQVMKIRENAISTFSKDQLGSFPKLETLEAGDNHFICSCELLSFILERPALVHVLVDWPDSYLCDSPPRLHGQRLQDARPSVLECHQAALVSGVCCALLLLILLLGALCYHFHGLWYLRMMWAWLRAKRKPKKAPCRDLCYDAFVSYSEQDSYWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDFSHFRLFDENNDAAILVLLEPIEKKAIPQRFCKLRKIMNTKTYLEWPLDEGQREVFWANLRTAIKS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0005515 (protein binding), GO:0008289 (lipid binding), GO:0042277 (peptide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0007272 (ensheathment of neurons), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050793 (regulation of developmental process), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002253 (activation of immune response), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0007275 (multicellular organism development), GO:0001775 (cell activation), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0001666 (response to hypoxia), GO:0032103 (positive regulation of response to external stimulus), GO:0044085 (cellular component biogenesis), GO:0043207 (response to external biotic stimulus), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0070482 (response to oxygen levels), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0001817 (regulation of cytokine production), GO:0009725 (response to hormone), GO:0002218 (activation of innate immune response), GO:2001057 (reactive nitrogen species metabolic process), GO:0006082 (organic acid metabolic process), GO:0050778 (positive regulation of immune response), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0001819 (positive regulation of cytokine production), GO:0031349 (positive regulation of defense response), GO:0051962 (positive regulation of nervous system development), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0002764 (immune response-regulating signaling pathway), GO:0045597 (positive regulation of cell differentiation), GO:0008366 (axon ensheathment), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0002269 (leukocyte activation involved in inflammatory response), GO:0008285 (negative regulation of cell population proliferation), GO:0009636 (response to toxic substance), GO:0006952 (defense response), GO:1901700 (response to oxygen-containing compound), GO:0061900 (glial cell activation), GO:0010033 (response to organic substance), GO:0002831 (regulation of response to biotic stimulus), GO:2000026 (regulation of multicellular organismal development), GO:0050776 (regulation of immune response), GO:0042127 (regulation of cell population proliferation), GO:0002757 (immune response-activating signaling pathway), GO:1901698 (response to nitrogen compound), GO:0002833 (positive regulation of response to biotic stimulus), GO:0009617 (response to bacterium), GO:0002274 (myeloid leukocyte activation), GO:1901652 (response to peptide), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0002758 (innate immune response-activating signaling pathway), GO:1901654 (response to ketone), GO:0043436 (oxoacid metabolic process), GO:0048545 (response to steroid hormone), GO:0002237 (response to molecule of bacterial origin), GO:0010001 (glial cell differentiation), GO:0050769 (positive regulation of neurogenesis), GO:0070542 (response to fatty acid), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0032288 (myelin assembly), GO:0007399 (nervous system development), GO:0036293 (response to decreased oxygen levels), GO:0007417 (central nervous system development), GO:0001774 (microglial cell activation), GO:0032496 (response to lipopolysaccharide), GO:0032733 (positive regulation of interleukin-10 production), GO:0045088 (regulation of innate immune response), GO:0042552 (myelination), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0042116 (macrophage activation), GO:0021782 (glial cell development), GO:0010628 (positive regulation of gene expression), GO:0051960 (regulation of nervous system development), GO:0045685 (regulation of glial cell differentiation), GO:0043434 (response to peptide hormone), GO:0032291 (axon ensheathment in central nervous system), GO:0022008 (neurogenesis), GO:0006954 (inflammatory response), GO:0010243 (response to organonitrogen compound), GO:0033993 (response to lipid), GO:0032653 (regulation of interleukin-10 production), GO:0014070 (response to organic cyclic compound), GO:0046209 (nitric oxide metabolic process), GO:0022010 (central nervous system myelination), GO:0002221 (pattern recognition receptor signaling pathway), GO:0048709 (oligodendrocyte differentiation), GO:0019752 (carboxylic acid metabolic process), GO:0032570 (response to progesterone), GO:0048713 (regulation of oligodendrocyte differentiation), GO:0050767 (regulation of neurogenesis), GO:0014003 (oligodendrocyte development), GO:0032868 (response to insulin), GO:0042063 (gliogenesis), GO:0014015 (positive regulation of gliogenesis), GO:0045687 (positive regulation of glial cell differentiation), GO:0150076 (neuroinflammatory response), GO:0048714 (positive regulation of oligodendrocyte differentiation), GO:0006690 (icosanoid metabolic process), GO:0002224 (toll-like receptor signaling pathway), GO:0014013 (regulation of gliogenesis), GO:0006691 (leukotriene metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0009986 (cell surface), GO:0044297 (cell body)