lokahq/bioreason-rl huggingface dataset:
Protein: Pyruvate kinase (O62619)
Organism: Drosophila melanogaster (Fruit fly)
InterPro domains:
- IPR011037: Pyruvate kinase-like, insert domain superfamily (homologous_superfamily) [120-221]
- IPR015806: Pyruvate kinase, insert domain superfamily (homologous_superfamily) [120-222]
- IPR018209: Pyruvate kinase, active site (active_site) [268-280]
- IPR015795: Pyruvate kinase, C-terminal (domain) [413-530]
- IPR015793: Pyruvate kinase, barrel (domain) [47-378]
- IPR040442: Pyruvate kinase-like domain superfamily (homologous_superfamily) [46-388]
- IPR001697: Pyruvate kinase (family) [26-532]
- IPR036918: Pyruvate kinase, C-terminal domain superfamily (homologous_superfamily) [376-532]
- IPR015813: Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily (homologous_superfamily) [22-397]
Sequence:
MVNVTIYDEAPQLKPNEVPQNMAAGADTQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGTIDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIVTVE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004743 (pyruvate kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0042221 (response to chemical), GO:0033500 (carbohydrate homeostasis), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0009743 (response to carbohydrate), GO:0042593 (glucose homeostasis), GO:0034285 (response to disaccharide), GO:0009744 (response to sucrose)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0043229 (intracellular organelle), GO:0045495 (pole plasm), GO:0043228 (non-membrane-bounded organelle), GO:0043186 (P granule), GO:0060293 (germ plasm), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: L-lactate dehydrogenase (Q27888)
Organism: Caenorhabditis elegans
Subcellular location: Cytoplasm
InterPro domains:
- IPR015955: Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (homologous_superfamily) [161-331]
- IPR001557: L-lactate/malate dehydrogenase (family) [20-328]
- IPR011304: L-lactate dehydrogenase (family) [20-332]
- IPR001236: Lactate/malate dehydrogenase, N-terminal (domain) [22-160]
- IPR018177: L-lactate dehydrogenase, active site (active_site) [190-196]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [16-160]
- IPR022383: Lactate/malate dehydrogenase, C-terminal (domain) [163-327]
Sequence:
MASTIKEVFAEIAAPVENSHGKVTVVGVGQVGMACAYSILQQNLANELCLVDVVADKLKGEMMDLQHGLAFTRHCTVKADTDYSITAGSKLCVVTAGARQREGETRLSLVQRNVEIFKGIIPQLVKYSPDTCILVVSNPVDVLTYVTWKLSGLPRERVFGSGTNLDSARFRFLLSEKLNIAPSSCHGWIIGEHGDSSVAVWSGVNVAGVTLHEIKPDIGEKTDNEHWEAEIHKKVVDSAYEIIKLKGYTSWAIGLSVAKIAQGIFSNSRNVFALSTNVKGFHGINDDVYLSLPVVLGSAGLTHVVKQQLTEAEVQKLHNSAKALLEVQNGIVM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004457 (lactate dehydrogenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0006089 (lactate metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0006090 (pyruvate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0042995 (cell projection), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium), GO:0097730 (non-motile cilium)
Protein: L-lactate dehydrogenase (Q95028)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cytoplasm
InterPro domains:
- IPR015955: Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (homologous_superfamily) [161-330]
- IPR001557: L-lactate/malate dehydrogenase (family) [21-327]
- IPR011304: L-lactate dehydrogenase (family) [20-331]
- IPR001236: Lactate/malate dehydrogenase, N-terminal (domain) [22-160]
- IPR018177: L-lactate dehydrogenase, active site (active_site) [190-196]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [4-160]
- IPR022383: Lactate/malate dehydrogenase, C-terminal (domain) [163-323]
Sequence:
MAAIKDSLLAQVAEVLPSSGHKVTIVGIGQVGMASAFSILAQNVSKEVCLIDVCADKLQGELMDLQHGSNFLKNPQITASTDFAASANSRLCIVTAGVRQKEGESRLSLVQRNTDILKNIIPKLVEYSPDTILLMVSNPVDIMTYVAWKLSGLPKNRVIGSGTNLDSSRFRFLMSQRLGVAPTSCHGWIIGEHGDSSVPVWSGVNIAGVRLRELNPILGTGEDPEKWNELHKQVVDSAYEVIKLKGYTSWAIGLSTASLASAILRNTSSVAAVSTSVLGEHGIDKDVFLSLPCVLNANGVTSVVKQILTPTEVEQLQKSANIMSDVQAGLKF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004457 (lactate dehydrogenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0006089 (lactate metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0006090 (pyruvate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Protein LOWER TEMPERATURE 1 (Q6IDA6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Supports abscisic acid (ABA) responses and drought tolerance by regulating the dynamic localization and stability (preventing degradation by the proteasome) of CAR proteins (C2-domain ABA-related, e.g. CAR9)
Subcellular location: Nucleus
InterPro domains:
- IPR036361: SAP domain superfamily (homologous_superfamily) [124-162]
- IPR003034: SAP domain (domain) [127-162]
- IPR018276: DET1- and DDB1-associated protein 1 domain (domain) [18-76]
- IPR033575: DET1- and DDB1-associated protein 1-like (family) [17-151]
Sequence:
MEASSSQPSDSSDQTASKFLSDLPSRGFLSSTVVSSNPGSLRVYICEHDTSPPEGQLIKTNQQNILIRSLLLKKQKGESSSKDSKGTAEDGPKKRAANRALDDRSSAKRAANASRQEGSSSRTGERDFQSLTVEKLRAMLKEKGLPTKGRKDELIARLKSAN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0065007 (biological regulation), GO:0009628 (response to abiotic stimulus), GO:0065008 (regulation of biological quality), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0001101 (response to acid chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:1902074 (response to salt), GO:0031647 (regulation of protein stability)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Lytic polysaccharide monooxygenase NCU01050 (Q1K8B6)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
Function: Catalyzes the oxidative cleavage of glycosidic bonds in cellulosic substrates via a copper-dependent mechanism . In the presence of an exogenous reductant ascorbic acid, degrades phosphoric acid swollen cellulose (PASC) to cello-oligosaccharides and 4-ketoaldoses, the end products oxidized at the non-reducing end . Somewhat active toward tamarind xyloglucan and konjac glucomannan, with improved activity with glucomannan in the presence of PASC. H(2)O(2) is able to substitute for O(2) in reactions with PASC, xyloglucan and glucomannan. Very weak activity on cellopentaose. No activity with birchwood xylan or ivory nut mannan. Disrupts plant cell wall polysaccharide substrates, such as recalcitrant crystalline cellulose (Probable)
Subcellular location: Secreted
InterPro domains:
- IPR049892: Auxiliary Activity family 9 (family) [3-238]
- IPR005103: Auxiliary Activity family 9, catalytic domain (domain) [16-236]
Sequence:
MKVLAPLVLASAASAHTIFSSLEVNGVNQGLGEGVRVPTYNGPIEDVTSASIACNGSPNTVASTSKVITVQAGTNVTAIWRYMLSTTGDSPADVMDSSHKGPTIAYLKKVDNAATASGVGNGWFKIQQDGMDSSGVWGTERVINGKGRHSIKIPECIAPGQYLLRAEMIALHAASNYPGAQFYMECAQLNVVGGTGAKTPSTVSFPGAYSGSDPGVKISIYWPPVTSYTVPGPSVFTC
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0008810 (cellulase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009056 (catabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0016052 (carbohydrate catabolic process), GO:0009057 (macromolecule catabolic process), GO:0005976 (polysaccharide metabolic process), GO:0000272 (polysaccharide catabolic process), GO:0044042 (glucan metabolic process), GO:0009251 (glucan catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Multidrug resistance protein 1 (Q5ABU7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Plasma membrane multidrug efflux pump that confers resistance to numerous chemicals including azoles such as fluconazole, voriconazole, and benztriazoles, as well as to benomyl, cycloheximide, methotrexate, 4-nitroquinoline-N-oxide, sulfometuron methyl, cerulenin, and brefeldin A
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR020846: Major facilitator superfamily domain (domain) [116-557]
- IPR001958: Tetracycline resistance protein TetA/multidrug resistance protein MdtG-like (family) [159-297]
- IPR011701: Major facilitator superfamily (family) [123-511]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [101-559]
Sequence:
MHYRFLRDSFVGRVTYHLSKHKYFAHPEEAKDYIVPEKYLADYKPTLADDTSINFEKEEIDNQGEPNSSQSSSSNNTIVDNNNNNDNDVDGDKIVVTWDGDDDPENPQNWPTLQKAFFIFQISFLTTSVYMGSAVYTPGIEELMHDFGIGRVVATLPLTLFVIGYGVGPLVFSPMSENAIFGRTSIYIITLFLFVILQIPTALVNNIAGLCILRFLGGFFASPCLATGGASVADVVKFWNLPVGLAAWSLGAVCGPSFGPFFGSILTVKASWRWTFWFMCIISGFSFVMLCFTLPETFGKTLLYRKAKRLRAITGNDRITSEGEVENSKMTSHELIIDTLWRPLEITVMEPVVLLINIYIAMVYSILYLFFEVFPIYFVGVKHFTLVELGTTYMSIVIGIVIAAFIYIPVIRQKFTKPILRQEQVFPEVFIPIAIVGGILLTSGLFIFGWSANRTTHWVGPLFGAATTASGAFLIFQTLFNFMGASFKPHYIASVFASNDLFRSVIASVFPLFGAPLFDNLATPEYPVAWGSSVLGFITLVMIAIPVLFYLNGPKLRARSKYAN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901474 (azole transmembrane transporter activity), GO:0042910 (xenobiotic transmembrane transporter activity), GO:1901618 (organic hydroxy compound transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0098754 (detoxification), GO:0050896 (response to stimulus), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:1990961 (xenobiotic detoxification by transmembrane export across the plasma membrane), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0055085 (transmembrane transport), GO:0140352 (export from cell), GO:0140115 (export across plasma membrane), GO:0006979 (response to oxidative stress), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0046618 (xenobiotic export from cell), GO:0009636 (response to toxic substance), GO:0034599 (cellular response to oxidative stress), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0042908 (xenobiotic transport), GO:0062197 (cellular response to chemical stress), GO:0015850 (organic hydroxy compound transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Enoyl-[acyl-carrier-protein] reductase, mitochondrial (Q9V6U9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro
Subcellular location: Mitochondrion
InterPro domains:
- IPR013149: Alcohol dehydrogenase-like, C-terminal (domain) [175-296]
- IPR011032: GroES-like superfamily (homologous_superfamily) [23-180]
- IPR020843: Enoylreductase domain (domain) [36-352]
- IPR013154: Alcohol dehydrogenase-like, N-terminal (domain) [50-128]
- IPR051034: Mitochondrial Enoyl-ACP Reductase (family) [17-355]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [137-319]
Sequence:
MSVVAKSLKYTQHGEPQEVLQLVEDKLPDPKDNQVLVKILAAPINPADINTIQGKYPVKPKFPAVGGNECVAEVICVGDKVKGFEAGQHVIPLASGLGTWTTHAVYKEDQLLIVSKKVGLAEAATSTVNPTTAYRMLKDFVQLCPGDTVIQNGANSAVGQAVHQLCRAWGINSVGIVRDRPEIAELKQMLQCLGATEVLTEAEIRTSDIFKSGKLKKPRLAFNCVGGKSATEVSRHLDNGGVLVTYGGMSREPVTVATGPLIFKDIAFRGFWMTRWSKENYSSPERSKMFKEIFELMEQGKFVAPNHEMVPLAKFKDAAAAALSFKGFTGKKYILDMSI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0016628 (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Molybdopterin synthase sulfur carrier subunit (Q9Z224)
Organism: Mus musculus (Mouse)
Function: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin
Subcellular location: Cytoplasm, cytosol
InterPro domains:
- IPR044672: Molybdopterin synthase sulfur carrier subunit (family) [3-88]
- IPR016155: Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp (homologous_superfamily) [6-88]
- IPR003749: Sulfur carrier ThiS/MoaD-like (family) [9-88]
- IPR012675: Beta-grasp domain superfamily (homologous_superfamily) [5-88]
- IPR028887: Molybdopterin synthase sulfur carrier subunit, eukaryote (family) [6-88]
Sequence:
MVPRCQIDVLYFAKSAEIAGVRSETISVPQEIKASELWKELEMLHPGLADVRNQVIFAVRQEYVELGDQQLLLQPGDEVAIIPPISGG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051189 (prosthetic group metabolic process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043545 (molybdopterin cofactor metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0032324 (molybdopterin cofactor biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0019720 (Mo-molybdopterin cofactor metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0006777 (Mo-molybdopterin cofactor biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Molybdopterin synthase catalytic subunit (Q9Z223)
Organism: Mus musculus (Mouse)
Function: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group
Subcellular location: Cytoplasm, cytosol
InterPro domains:
- IPR036563: Molybdopterin biosynthesis MoaE subunit superfamily (homologous_superfamily) [27-186]
- IPR028888: Molybdopterin synthase catalytic subunit, eukaryotes (family) [44-186]
- IPR003448: Molybdopterin biosynthesis MoaE (family) [50-178]
Sequence:
MSSLEISNSCFSPETRSPSSRQSVEDNASEPSGKDVDDVQEKPKDIIQFTAEKLSVGEVSQLVVSPLCGAVSLFVGTTRNNFEGKKVISLEYEAYVPMAENEIRKICNDIRQKWPVRHIAVFHRLGLVPVSEASTVIAVSSAHRAASLEAVSYAIDSLKAKVPIWKKEIYEESTSSWKRNKECFWAAGD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051189 (prosthetic group metabolic process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0019538 (protein metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0043545 (molybdopterin cofactor metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0019720 (Mo-molybdopterin cofactor metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0032324 (molybdopterin cofactor biosynthetic process), GO:0006777 (Mo-molybdopterin cofactor biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)