Protein: Paired box protein Pax-8 (A0A024R531)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus
InterPro domains:
- IPR043565: PAX family (family) [5-363]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [11-133]
- IPR022130: Paired-box protein 2 C-terminal (domain) [282-386]
- IPR001523: Paired domain (domain) [9-135]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [1-141]
- IPR043182: Paired DNA-binding domain (domain) [43-59]
Sequence:
MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0038023 (signaling receptor activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0004888 (transmembrane signaling receptor activity), GO:0016500 (protein-hormone receptor activity), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0004930 (G protein-coupled receptor activity), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0065008 (regulation of biological quality), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0001763 (morphogenesis of a branching structure), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0048729 (tissue morphogenesis), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0009725 (response to hormone), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:1901360 (organic cyclic compound metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0072028 (nephron morphogenesis), GO:0072006 (nephron development), GO:0048839 (inner ear development), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0035239 (tube morphogenesis), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:1901576 (organic substance biosynthetic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0032350 (regulation of hormone metabolic process), GO:0046483 (heterocycle metabolic process), GO:0061138 (morphogenesis of a branching epithelium), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0010817 (regulation of hormone levels), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0046883 (regulation of hormone secretion), GO:0032352 (positive regulation of hormone metabolic process), GO:0009888 (tissue development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0060562 (epithelial tube morphogenesis), GO:0072009 (nephron epithelium development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0072088 (nephron epithelium morphogenesis), GO:0061005 (cell differentiation involved in kidney development), GO:0048732 (gland development), GO:0002009 (morphogenesis of an epithelium), GO:0060993 (kidney morphogenesis), GO:0010468 (regulation of gene expression), GO:0048754 (branching morphogenesis of an epithelial tube), GO:0090276 (regulation of peptide hormone secretion), GO:0061326 (renal tubule development), GO:0007399 (nervous system development), GO:0034698 (response to gonadotropin), GO:0090304 (nucleic acid metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0007417 (central nervous system development), GO:0072164 (mesonephric tubule development), GO:0051252 (regulation of RNA metabolic process), GO:0010467 (gene expression), GO:0072001 (renal system development), GO:0035270 (endocrine system development), GO:0071599 (otic vesicle development), GO:0071310 (cellular response to organic substance), GO:0019438 (aromatic compound biosynthetic process), GO:0007423 (sensory organ development), GO:0030855 (epithelial cell differentiation), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0032870 (cellular response to hormone stimulus), GO:0090087 (regulation of peptide transport), GO:0072273 (metanephric nephron morphogenesis), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051046 (regulation of secretion), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0060429 (epithelium development), GO:0072210 (metanephric nephron development), GO:0001822 (kidney development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0072080 (nephron tubule development), GO:0016070 (RNA metabolic process), GO:0001823 (mesonephros development), GO:0060231 (mesenchymal to epithelial transition), GO:2001141 (regulation of RNA biosynthetic process), GO:0043583 (ear development), GO:0001656 (metanephros development), GO:0061333 (renal tubule morphogenesis), GO:0003338 (metanephros morphogenesis), GO:0001658 (branching involved in ureteric bud morphogenesis), GO:0071371 (cellular response to gonadotropin stimulus), GO:0030878 (thyroid gland development), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0001657 (ureteric bud development), GO:0072171 (mesonephric tubule morphogenesis), GO:0035850 (epithelial cell differentiation involved in kidney development), GO:0072073 (kidney epithelium development), GO:0006355 (regulation of DNA-templated transcription), GO:0002791 (regulation of peptide secretion), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0072078 (nephron tubule morphogenesis), GO:0060675 (ureteric bud morphogenesis), GO:0072207 (metanephric epithelium development), GO:0072163 (mesonephric epithelium development), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)