lokahq/bioreason-rl huggingface dataset:
Protein: Solute carrier family 7 member 14 (Q8BXR1)
Organism: Mus musculus (Mouse)
Function: Imports 4-aminobutanoate (GABA) into lysosomes. May act as a GABA sensor that regulates mTORC2-dependent INS signaling and gluconeogenesis. The transport mechanism and substrate selectivity remain to be elucidated
Subcellular location: Lysosome membrane; Multi-pass membrane protein. Note=Exhibits a punctated pattern in the cytoplasm, which partially ovelaps with lysosomes
InterPro domains:
- IPR029485: Cationic amino acid transporter, C-terminal (domain) [627-677]
- IPR002293: Amino acid/polyamine transporter I (family) [53-434]
Sequence:
MSGFLASLDPRRVQWGAAWYAMHSRILRTKPVESMLEGTGTTSAHGTKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHSISRWMVDTVGTLNGLGKGEESYPDLLALVIAVIVTIIVALGVKNSVGFNNVLNVLNLAVWVFIMIAGLFFINGKYWAEGQFLPHGWSGVLQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSMILTLMVPYYAIDTESPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTETPVVACIVSGFLAALLSLLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKFLSEEHTKKKEGILADCEKETCSPVSEGEEFSSPATNTCGAKNLPSLGDNEMLIGKSDKSAYNVNHPNYGTVDMTTGIEADESENIYLIKLKKLIGPRYYTMRIRLGLPGKMDRPTAATGHTVTICVLLLFILMFIFCSFIIFGSEYISGQSWWAILLVVLMMLLISVLVFVILQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGMLIYFGYGIWNSTLEISAREQALHQSTYQRYDVDDPFSVEEGFSYATEGESQEDWGGPAEDKGFYYQQMSDAKANSRTSSKAKSKSKHKQNSEALIANDELDCSPE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0006865 (amino acid transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0015802 (basic amino acid transport), GO:0046942 (carboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: S-adenosylmethionine sensor upstream of mTORC1 (Q9W138)
Organism: Drosophila melanogaster (Fruit fly)
Function: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase
InterPro domains:
- IPR021867: S-adenosylmethionine-dependent methyltransferase Bmt2-like (family) [3-300]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [99-285]
Sequence:
MATEEHQRLASIVKSCHESLRQLTKEYGATAAWQEHTSPRNAKQLAEYAKAMKQLAAIWETNDGKVELQARSRIKWAIDYITKYFFTEGIYLQKRQREQRLLESYRAEGKLGEVQCRLMEEPPDRLHVLDVGSCFNPFSSAPHLEVTALDLCPATEDVLQADFLKVEVVPGIREPELEEGSVRRLPASHYECVIFSLLLEYMPSAEQRLQCCLQAYDLLLPEGILVLITPDSQHVGKNAHLMKNWRYSLARIGLLRVRFEKLPHISCMVFRKAISRELSQHWASIHREEGMCEEIRIPQDDS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:1901681 (sulfur compound binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:1904047 (S-adenosyl-L-methionine binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:1902532 (negative regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0032007 (negative regulation of TOR signaling), GO:0032006 (regulation of TOR signaling), GO:1904262 (negative regulation of TORC1 signaling), GO:1903432 (regulation of TORC1 signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Solute carrier family 5 member 4 (P31636)
Organism: Sus scrofa (Pig)
Function: Low-affinity sodium/D-glucose symporter with a great selectivity for sugars (D-glucose >> D-galactose). Na(+) and D-glucose transport are tightly coupled at neutral pH, but at acidic pH, ion transport is uncoupled from sugar transport
Subcellular location: Cell membrane; Multi-pass membrane protein
InterPro domains:
- IPR038377: Sodium/glucose symporter superfamily (homologous_superfamily) [45-572]
- IPR001734: Sodium/solute symporter (family) [25-506]
- IPR018212: Sodium/solute symporter, conserved site (conserved_site) [174-494]
Sequence:
MASTLSPSTVTKTPGPPEISERIQNAADISVIVIYFVVVMAVGLWAMLRTNRGTVGGFFLAGRDVTWWPMGASLFASNIGSGHFVGLAGTGAASGIAIAAFEWNALLLLLVLGWFFVPIYIKAGVMTMPEYLRKRFGGKRLQIYLSILSLFICVALRISSDIFSGAIFIKLALGLDLYLAIFSLLAITAIYTITGGLASVIYTDTLQTIIMLIGSFILMGFAFVEVGGYESFTEKYMNAIPTIVEGDNLTISPKCYTPQGDSFHIFRDAVTGDIPWPGMIFGMTVVAAWYWCTDQVIVQRCLSGKDMSHVKAACIMCGYLKLLPMFLMVMPGMISRILYTEKVACVVPSECVKHCGTEVGCSNYAYPLLVMELMPSGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDLYTKIRKQASEKELLIAGRLFIILLIVISIVWVPLVQVAQNGQLFHYIESISSYLGPPIAAVFLLAIFCKRVNEQGAFWGLIIGFVMGLIRMIAEFVYGTGSCLAASNCPQIICGVHYLYFALILFFVSILVVLAISLLTKPIPDVHLYRLCWALRNSTEERIDLDAEEKRHEEAHDGVDEDNPEETRGCLRKAYDLFCGLQRKGPKLSKEEEEAQKRKLTDTSEKPLWKTIVNINAILLLAVAVFVHGYFA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015144 (carbohydrate transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005402 (carbohydrate:monoatomic cation symporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0015293 (symporter activity), GO:0015294 (solute:monoatomic cation symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0034219 (carbohydrate transmembrane transport), GO:0006810 (transport), GO:0015749 (monosaccharide transmembrane transport), GO:0071702 (organic substance transport), GO:0008645 (hexose transmembrane transport), GO:0008643 (carbohydrate transport), GO:1904659 (glucose transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Q09508)
Organism: Caenorhabditis elegans
Function: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)
Subcellular location: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
InterPro domains:
- IPR015939: Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal (domain) [495-646]
- IPR027477: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily (homologous_superfamily) [271-389]
- IPR003953: FAD-dependent oxidoreductase 2, FAD-binding domain (domain) [44-439]
- IPR003952: Fumarate reductase/succinate dehydrogenase, FAD-binding site (binding_site) [78-87]
- IPR011281: Succinate dehydrogenase, flavoprotein subunit (family) [41-646]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [28-455]
- IPR014006: Succinate dehydrogenase/fumarate reductase, flavoprotein subunit (family) [44-586]
- IPR030664: FAD-dependent oxidoreductase SdhA/FrdA/AprA (family) [32-646]
- IPR037099: Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily (homologous_superfamily) [485-646]
Sequence:
MLRAASNGLRNTVAARSVSLSAANHSDAKRSDIAQYKVVDHAYDAVVVGAGGAGLRAAMGLAEGGLKTAVITKLFPTRSHTVAAQGGINAALGNMNPDNWRWHFYDTVKGSDWLGDQDAIHYMTREAERAVIELENYGMPFSRTTDGKIYQRAFGGQSNDFGRGGQAHRTCCVADRTGHSLLHTLYGASLQYNCNYFVEYFALDLIMENGVCVGVIAMDLEDGTIHRFRSKNTVLATGGYGRAFFSCTSAHTCTGDGTALTARAGINNSDMEFVQFHPTGIYGAGCLITEGSRGEGGYLVNSAGERFMERYAPNAKDLASRDVVSRSMTVEIMEGRGVGPDKDHIYLQLHHLPAEQLQQRLPGISETAMIFAGVDVTKEPIPVIPTVHYNMGGVPTNYKGQVLNYTPKKGDEVVPGLYAAGECGAHSVHGANRLGANSLLDLVIFGRACAIDILKNTSAGVGVPELPKNAGEASVANIDKLRHNKGDISTAELRLTMQKSMQNHAAVFRRGDILKEGVKVLSKLYKDQAHLNVADKGLVWNSDLIETLELQNLLINATQTIVAAENREESRGAHARDDFPDRLDELDYSKPLEGQTKKELKDHWRKHSIIRSNIETGEVSLDYRPVIDTTLDKSETDWVPPKVRSY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0000104 (succinate dehydrogenase activity), GO:0016635 (oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0022900 (electron transport chain)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Protein SHMOOSE (C0HM83)
Organism: Homo sapiens (Human)
Function: Increases neural cell metabolic activity and mitochondrial oxygen consumption rate
Subcellular location: Mitochondrion. Nucleus. Note=Detected in neuronal mitochondria and nuclei
InterPro domains:
Sequence:
MPPCLTTWLSQLLKDNSYPLVLGPKNFGATPNKSNNHAHYYNHPNPDFPNSPHPYHPR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0002682 (regulation of immune system process), GO:0050793 (regulation of developmental process), GO:0051239 (regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:1903706 (regulation of hemopoiesis), GO:2000026 (regulation of multicellular organismal development), GO:0045637 (regulation of myeloid cell differentiation), GO:1902105 (regulation of leukocyte differentiation), GO:0060284 (regulation of cell development), GO:0002761 (regulation of myeloid leukocyte differentiation), GO:0045670 (regulation of osteoclast differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Small integral membrane protein 45 (A0A590UK83)
Organism: Homo sapiens (Human)
Function: Plays a role in the regulation of neuron maturation
Subcellular location: Nucleus. Cytoplasm . Membrane; Single-pass membrane protein
InterPro domains:
Sequence:
MSMAACPEAPEPSFLREVPSSPASTQWHRPCNFRQVEANPRKEPKNLVWRDVSLGQTSRTPRGSGLELVRVCGGGMQRDKTVVEERVGEERERERERVWGERASMGR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0030155 (regulation of cell adhesion), GO:0016043 (cellular component organization), GO:0045785 (positive regulation of cell adhesion), GO:0044085 (cellular component biogenesis), GO:0010811 (positive regulation of cell-substrate adhesion), GO:0045229 (external encapsulating structure organization), GO:0043062 (extracellular structure organization), GO:0010810 (regulation of cell-substrate adhesion), GO:0022407 (regulation of cell-cell adhesion), GO:0022607 (cellular component assembly), GO:0001952 (regulation of cell-matrix adhesion), GO:0030198 (extracellular matrix organization), GO:0085029 (extracellular matrix assembly), GO:0001954 (positive regulation of cell-matrix adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Seven transmembrane protein 1 (Q10482)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Subcellular location: Membrane; Multi-pass membrane protein
InterPro domains:
- IPR051415: Lysosomal/Vacuolar Amino Acid Transporter 1 (family) [15-270]
- IPR006603: PQ-loop repeat (repeat) [17-234]
Sequence:
MSVIAPSFDMANILTELSSFLGALSLGCWVVLLIPQLLENYKNQSGESISDLFLIIWLIGDFFNVLGSIYGNVSSTVLVLSFYYIVSDSTLLMQIYYYRWKAARRIASREHEPLLQSRSLEEGLHAPIGKQQIWWDRLSTRQQFGVMGCVVIVSTIVGNLIISSASSDKSDDDLNAWPFTAGCISSVLYFCARIPQIIKNHKAKSTEGLSIIFFVLASVGNTSYAFSILVFPASDYLNYTYANLPWILGAFSTIFLDIYIFYQFIKYRNHY
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015174 (basic amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:1903825 (organic acid transmembrane transport), GO:0034486 (vacuolar transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:1905039 (carboxylic acid transmembrane transport), GO:0003333 (amino acid transmembrane transport), GO:0006865 (amino acid transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0015802 (basic amino acid transport), GO:0046942 (carboxylic acid transport), GO:1990822 (basic amino acid transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Transcription initiation factor IIB (Q257B3)
Organism: Trypanosoma brucei brucei
Function: Specifically binds to the promoter of the spliced leader (SL) RNA gene and thus is essential for SLRNA transcription
Subcellular location: Nucleus
InterPro domains:
- IPR054332: Transcription factor IIB, C-terminal module 2 (domain) [203-308]
- IPR041189: Transcription factor IIB, C-terminal module 1 (domain) [96-193]
- IPR000812: Transcription factor TFIIB (family) [10-247]
Sequence:
MSTTTDFVGRNCPHCSAVDSLQTDDVMGEVACTACALVVAMGLEENVFTRYNENATYEDVDHHRERNANPTAATSAAGSLSAADPHMSSTSSKVVLHPTMLNCMRGLHKKAVLPEPVLDRGIELARAFVGGRRARGQRVERQPDVAAACLMIAAEEAQQPLPLAEVRCLDSSLGDVELRRADIVRELHLEDSERRLRDTFADNLLVKYILKLGLQVSLYLPHCKRLLTALGRVEALAGLTVADRVTTALLLARTAQTLSWEQGTHISKGKECDLGMEAIYANFSSKAHLEVTKVNKIMHLAVDVLPLIQAAFQDCGEPTAGKRKVDKNSEPEASGGTKRVKREET
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000182 (rDNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0010467 (gene expression), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0016070 (RNA metabolic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0006366 (transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: THO complex subunit tho7 (Q9P7J4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export (By similarity). The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription (By similarity). THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase (By similarity). The THO complex is also required to maintain TRAMP complex occupancy at sites of snoRNA transcription thus promoting exosome-mediated degradation of snoRNA precursors
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR008501: THO complex subunit 7/Mft1 (family) [3-128]
Sequence:
MEETAIRSRLTVEERPLKRLISRCLGFAAQNVDEANLRDLEIEFSALSAFWLRLQMQLDMNAKEVDVYEGELKKTQTFCEAEKTEISQLEQDLLVAQEELRKREQYDELAKPIMSKGLRSRTEQQESIGKLQDAIRELEEENANYVKAWNLRKDIFDETLKQMNHLQSILHPPSNPESDSEEGIASEGENPSSSSSTQYKAK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0051236 (establishment of RNA localization), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0006403 (RNA localization), GO:0043170 (macromolecule metabolic process), GO:0071702 (organic substance transport), GO:0050658 (RNA transport), GO:0051169 (nuclear transport), GO:0071705 (nitrogen compound transport), GO:0010467 (gene expression), GO:0015931 (nucleobase-containing compound transport), GO:0006913 (nucleocytoplasmic transport), GO:0051028 (mRNA transport), GO:0006406 (mRNA export from nucleus), GO:0006405 (RNA export from nucleus), GO:0051168 (nuclear export), GO:0050657 (nucleic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Thiamine-triphosphatase (Q8JZL3)
Organism: Mus musculus (Mouse)
Function: Hydrolase highly specific for thiamine triphosphate (ThTP)
Subcellular location: Cytoplasm
InterPro domains:
- IPR033469: CYTH-like domain superfamily (homologous_superfamily) [4-217]
- IPR039582: Thiamine-triphosphatase (family) [1-218]
- IPR012177: Thiamine triphosphatase, eukaryotes (family) [1-222]
- IPR023577: CYTH domain (domain) [5-201]
Sequence:
MAQGLIEVERKFAPGPDTEERLQELGATLEHRVTFRDTYYDTSELSLMLSDHWLRQREGSGWELKCPGVTGVSGPHNEYVEVTSEAAIVAQLFELLGSGEQKPAGVAAVLGSLKLQEVASFITTRSSWKLALSGAHGQEPQLTIDLDSADFGYAVGEVEAMVHEKAEVPAALEKIITVSSMLGVPAQEEAPAKLMVYLQRFRPLDYQRLLEAASSGEATGDSAS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0043169 (cation binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0046872 (metal ion binding), GO:0016462 (pyrophosphatase activity), GO:0000287 (magnesium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006766 (vitamin metabolic process), GO:0006790 (sulfur compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0042723 (thiamine-containing compound metabolic process), GO:0006767 (water-soluble vitamin metabolic process), GO:0072527 (pyrimidine-containing compound metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)