Protein: Afadin, adherens junction formation factor (A0A804HJ20)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR002710: Dilute domain (domain) [668-915]
- IPR037977: Afadin, cargo binding domain (domain) [611-939]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [406-502]
- IPR036034: PDZ superfamily (homologous_superfamily) [1006-1106]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [39-347]
- IPR028842: Afadin (family) [1-1831]
- IPR000253: Forkhead-associated (FHA) domain (domain) [425-492]
- IPR001478: PDZ domain (domain) [1014-1100]
- IPR000159: Ras-associating domain (domain) [39-348]
Sequence:
MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELSPGRRNHFAYYNYHTYEDGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQEVDQVDQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPGLCRPPLPRDYEPPSPSPAPGAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYNEEEEEEDCSLAGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLTELENELNTK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0051015 (actin filament binding), GO:0050839 (cell adhesion molecule binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0045296 (cadherin binding), GO:0051020 (GTPase binding), GO:0003779 (actin binding), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0007267 (cell-cell signaling), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0007155 (cell adhesion), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0040013 (negative regulation of locomotion), GO:0071840 (cellular component organization or biogenesis), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0007154 (cell communication), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0044085 (cellular component biogenesis), GO:2000145 (regulation of cell motility), GO:2000146 (negative regulation of cell motility), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0030154 (cell differentiation), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0045785 (positive regulation of cell adhesion), GO:0022409 (positive regulation of cell-cell adhesion), GO:0002064 (epithelial cell development), GO:0051336 (regulation of hydrolase activity), GO:0022407 (regulation of cell-cell adhesion), GO:0010628 (positive regulation of gene expression), GO:0043933 (protein-containing complex organization), GO:0030334 (regulation of cell migration), GO:0043085 (positive regulation of catalytic activity), GO:0060429 (epithelium development), GO:0034330 (cell junction organization), GO:0010468 (regulation of gene expression), GO:0030855 (epithelial cell differentiation), GO:0030336 (negative regulation of cell migration), GO:0022607 (cellular component assembly), GO:0045446 (endothelial cell differentiation), GO:0043087 (regulation of GTPase activity), GO:0001885 (endothelial cell development), GO:0003158 (endothelium development), GO:0065003 (protein-containing complex assembly), GO:0051345 (positive regulation of hydrolase activity), GO:2000047 (regulation of cell-cell adhesion mediated by cadherin), GO:0045216 (cell-cell junction organization), GO:0034329 (cell junction assembly), GO:0007043 (cell-cell junction assembly), GO:0046931 (pore complex assembly), GO:0061028 (establishment of endothelial barrier), GO:0043547 (positive regulation of GTPase activity), GO:0120193 (tight junction organization), GO:0120192 (tight junction assembly), GO:0043297 (apical junction assembly), GO:0070830 (bicellular tight junction assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016604 (nuclear body), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0016607 (nuclear speck), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)