Protein: Intermembrane lipid transfer protein vps1302 (O42926)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). May play a role in mitochondrial lipid homeostasis, Golgi vesicle transport, reticulophagy, actin cytoskeleton organization and formation of the forespore membrane (By similarity)
Subcellular location: Golgi apparatus, trans-Golgi network
InterPro domains:
- IPR026854: Vacuolar protein sorting-associated protein 13, N-terminal domain (domain) [1-819]
- IPR017148: Vacuolar protein sorting-associated protein 13, fungi (family) [1-3042]
- IPR056747: VPS13-like, middle region (domain) [986-1755]
- IPR009543: Vacuolar protein sorting-associated protein 13, VPS13 adaptor binding domain (domain) [1790-2363]
- IPR056748: Intermembrane lipid transfer protein VPS13-like, C-terminal (domain) [2872-2938]
- IPR026847: Vacuolar protein sorting-associated protein 13 (family) [1-2938]
Sequence:
MLEGLLANFLNRLLGEYIENFDATQLKVAVWNGDVTLRNLQLKRSAFRKLELPISVQYGLVEELTLKIPWSSLKNKPVEIYIVGIRALASMEENVKSQSEVDPHQVLESKRRQMQLWEASQIGKAETAYDPKTQTFTESLITRMIDNIQINIRDIHIRFEHLPVSNVVPGGYSFGLLLSEFSIESCNEEWTSTFVETESQTIYKLCSLRGFGIYSDETAECIDKTDINELMNTFQALITDFQSREKDYIIAPVTGMAKVTINKLPTPEIPRFLSQISFRGFDVSLNDSQISCGMSLAHELQDVMSKLAFRKRIVGNVSLDTPLDYLRFIFQKTLHDIQQKHYARSWPAIKAFCEKRRNYIKLYKKKFLAVQLSADESKELDVLELNLDISQLKLFRSLAYQEIKNEGFEPQPPKQQGWGSWMWNSFRGASDENGEVTDDQRKTVIDAIGLNDSIIESAHVGDLQSNTSLFDVRLEVPSGKFSLLKYPKKENVISLELLNFFSQFKCNKKDYSFVANLGSLKMYNDDRNFLYPRETSNKEIETTSPSIFTLSFERSSSDDNDTDTLGINLRALEFFYDPNLLLRVKGFQSSLFANDNGRKLVRLANDAVTDFTSQTVQNLQEYLNEKRKLNVNFQFQTPLLIFPEDCNNPESFSLFVDAGFISITSQNVETNDKESNSESETLYHLIYDRYRVSLESARLLLGPLNELKNESNKINEEYYLMNELNTEIFIQAQRVPTPQYPRIKVEGNMPCLSFILSDAQFRILNNLASTMLKDGKASDDDDNGDWRPESSESLDSHESEYKLNNTPSEQSVKVSHFFEFNMKLGEVTLILCREDSQTKRNSMVSVNFAKLLLSFNQFEDNSHLRMSINSFHINDMLSKSSRDNNRQLMRCYAPDSVDAENTPVIVEIKSVKAGENQSETNTTVDFLCANGDFYLAKFSILTLIEFLPSFAPPPSNDKQSTPQVSNSAAGKMELNFKIHKIGLRLLENYESKPICIDLLALDLSVNSTKGISEVESRVDKIQVMAWDHEKDEIVTLIDSKQDSLFDLKCKMQEGWFIHSPNPSTDVNIKMGSFTMLCHKQPIEEILNYASNFGHYKAIVQSVKYLAETGTHQVQQGTNVNINLYISNPIFQIPLTLENGSSAMVEILPGSFSLKTPSWLPNLTLNLESKSTTLRTIYYSKDFDEKGNQITVLDDLNISLDGSIVQAVDSAITNYAIDLHCGISELLIHLSQAQYLILLKLASNLPEMLSIANAFSANVDAPSVMTLLSEELYSIDTVNDAISNLSQNSSFDMKFGLHFPKISLNLYDGTFITPENSLSPLSNFTLNEIRAEGSYDLKTGASALIKMASLAIEDVRSEKSRYFSNVIIPSTDTESQLQVSFQYKPDTSSILLEGDIFKSMYVLSLDHLLSIYYWFGQPLMEKKLESPDDVQSLQAESSVSTPAVTAASEKSISLSVRFDIRNTSLVFVADASKSTSQAIVLRTDQISLVKQLSYSLTVQKMGMFVTRMDKLDDGIQILDDFDIGFGLVQDCSENKSFSATLDLDRLLFRISVYDLLLLQSIAQASVSVISSYKDKSSSISENMNSGDYGQQILNASNIAAVQQKAEQTATTLLTVLGHDSLISEEFTINSAGIQLILISDAHCLPVFDFTIENFNVLVKDWSTNLSATTSLTLHCNAFNFAKSHWEPVIEPWTFSTTAIMKDGMHEVNINSDDIAQISLTPMMVTDVHRLIKFYLTNQENNIEKRPEGYPYVILNQTGYNLSIQYGNLNSSEMQSLSLPSGKCVPCRFESKEVLTSRMSSKVQDVATKVRVSFDSTWYPVDEVSVHQEGSFLYELKPRIDQRTFLLVTVVLLESNIKQIILSSPYSIVNRTKEVIEVVCNDRSGHRQSSVIKIDPNETGYVPLDLACLYPLRIRPVSKLGFLWSNQIVDWHSLNKSPLQYLTCESTSTSWKHNLLVFARNLMDGSLQNDYPFLQLNILPTLQIENLLPYEINLRIIERSSGNDWRSSLSPGDSLPILHTDSKSFLLMGINVPDLDLQPVDLPIIYTPISSGQDVQTSALLTASDKQDVVKLILKYEKLPGTNYVSKVMIYPPYVIFNHTDLSIQVTSSSPNSIRYTIPSGSYSNDIKPYFYSFDESGRKNRAMISIDNGTSWSADIGFDTLGSSSQVEVRKTNESDVCLLGMSISESSGKFCLTKSVTFTPRFVFKNHLDCTVSLREFGSSKVLHLPSNELIPMMYFSNPQEIALLLSLPSSNNHWTSPFLAQNVGIVHLKAFEFDDDDNNMSTTLLRLCVTLEDATFFVTITKEDKAWPFRLKNCTSREICYEQKRPDPESVDSRFLQGSRSMKYALNPGEEANYSWDFPILKSKLLQVEVGKAIHDLDISSVGQLEPWHPTELDQKIRIHPEVKVDSLTSLVTFNEIDLSKPKLPSRTNSNVKGSIVEQKFKLVLQLKGFGISLIDKKYEEFAYATLKNFTFRFDDSKDLNTFGMSLGWLQIDNQMLDSVYPIALFPTMITQEVKQDDPQLLQLRFSVLKDSSFNILYIKYASLLLQELSLEVEDRLVLTLLQLLYPSSDVSKDSASLSKNAFADKFEIPDLDADVYRSNVFFETLHLQPTRLNISFETSYESDQPAVKSSNPTLDFMTGILISTLGNIHDAPVQLNSILLENARGTLSEMANRVASHYKQQVGYQIYKIAGRADFLGNPVGLFNNVASGVFDMFYEPYQGFLLQDSQSFGDSFARGTSSFMRKTIYGVSDSVSKITGTISKGLSTMTMDPKYQNSRRRFRSRNRPKEAVYGVTAGANSFYDSMSSGFKGLKKPFTDPKNNSAGKFLKGFGKGMLGLATKPAIGLLDMTSNVSEGIRNSTDVRTNPEIDKVRVPRYVEFGGLIVPFKPYESLGKYMLSCLDDGKYAFDEYLYHAEIQNVDILYISTKHFIITGSNYIVKIAVPVKQISGLRVSEHDLNSSCLFTFAVFWQRCESLFDCEYLSTPNLELFVKEKKKPIMSITMSDSSAYGEELMRERFEHLLKAYEKMALMVAEQEEFNAKIEDMALKLLSEKYDNEAYQAELFYRLSNCVEKVLHNKISITDLKTEYEEILEQTLKKECKAYERSCIENVKLKKRTEQATAYYASSSSEP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0016043 (cellular component organization), GO:0006810 (transport), GO:0006869 (lipid transport), GO:0071702 (organic substance transport), GO:0061024 (membrane organization), GO:0120009 (intermembrane lipid transfer), GO:0015850 (organic hydroxy compound transport), GO:0015918 (sterol transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)