Protein: 5-hydroxytryptamine receptor 3B (Q9JJ16)
Organism: Rattus norvegicus (Rat)
Function: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation- selective channel complexes, which when activated cause fast, depolarizing responses in neurons
Subcellular location: Postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A
InterPro domains:
- IPR006201: Neurotransmitter-gated ion-channel (family) [24-431]
- IPR008132: 5-hydroxytryptamine 3 receptor (family) [117-344]
- IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [29-234]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [26-233]
- IPR049944: 5-hydroxytryptamine 3 receptor, transmembrane domain (domain) [236-432]
- IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [235-348]
- IPR008134: 5-hydroxytryptamine 3 receptor, B subunit (family) [13-382]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [242-326]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [235-434]
Sequence:
MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDIIINEFVDVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNQEDIENDKRSFLNDSEWQLLSVTSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGVFFTVCMALLVLSLSKSILLIKFLYEERHSEQERPLMCLRGDSDANESRLYLRAPCAEDTESPVRQEHQVPSDTLKDFWFQLQSINNSLRTRDQVYQKEVEWLAILCHFDQLLFRIYLAVLGLYTVTLCSLWALWSRM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0060089 (molecular transducer activity), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0030594 (neurotransmitter receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0099589 (serotonin receptor activity), GO:0022835 (transmitter-gated channel activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022824 (transmitter-gated monoatomic ion channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0065009 (regulation of molecular function), GO:0051050 (positive regulation of transport), GO:0032879 (regulation of localization), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0034762 (regulation of transmembrane transport), GO:0071495 (cellular response to endogenous stimulus), GO:0034764 (positive regulation of transmembrane transport), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0032409 (regulation of transporter activity), GO:0032411 (positive regulation of transporter activity), GO:0043270 (positive regulation of monoatomic ion transport), GO:0070848 (response to growth factor), GO:0034767 (positive regulation of monoatomic ion transmembrane transport), GO:0022898 (regulation of transmembrane transporter activity), GO:0043269 (regulation of monoatomic ion transport), GO:0071363 (cellular response to growth factor stimulus), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0032414 (positive regulation of ion transmembrane transporter activity), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0036477 (somatodendritic compartment), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0030424 (axon)