Protein: Intraflagellar transport protein 81 (A8B296)
Organism: Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia)
Function: Component of the intraflagellar transport complex B (IFT-B) involved in flagellar assembly (Probable)
Subcellular location: Cell projection, cilium, flagellum . Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, flagellum basal body. Note=Localizes to the cytoplasmic and membrane-bound portions of each of the eight axonemes, localizing particularly at the flagellar pores and at the distal flagellar tips . Localizes to the basal bodies . Main cytoplasmic localization in the posteriolateral axonemes. In the examined anterior and posteriolateral flagella, higher levels are observed in the cytoplasmic portions of the axonemes compared to the membrane-bound portions, but lower levels compared to the flagellar pores. Dynamic in the cytoplasmic axonemes and at flagellar pores, accumulating at the flagellar pores
InterPro domains:
- IPR029600: Intraflagellar transport protein 81 (family) [7-667]
- IPR041146: IFT81, calponin homology domain (domain) [8-139]
- IPR043016: IFT81, N-terminal domain superfamily (homologous_superfamily) [6-146]
Sequence:
MQPPTSTDQLQTITDGLNLPPFERRMTLITLSEILHDPVRAMQLLADVAYQVRPHSLAEDSKAVPPPVKVNAANLEQVAAGITDFTVCLLNLNESRSMADKQAFVQELVLSDSANMRVLLSAILKDLAASRETIYVSKFKLPPVIPADYMVDPQIQTLLSQLREAQSRFTEALNQNRDVQKDQILQKMERLATDKTTFLTRRDKLFDRVKQAKALSVPKEAVRLASRRRVALSEIEELKTQINSQNEIRRAALNAAKAVVNSARGTPANILEASEAENKRLKQEIINLTAEITEKESLAHLIQSEPGQEAIELMENELETLRTDLVKYREMVSTVGSPDEEDNEQEKMSFLNQQITKIKTQRAQLENRLTNARRESAEVDAEVAKRCSSTDMASLMKDIDDMDSIPMLLFKNLLSKGRALKPLHKKAMDEQQLLRKENAIVSRTKDILAAIPNLSAEAPDELTDAGGLRPIGGGKQRVLGSIGGVGLNAKNLMEAKAVLAELDATLQQKKRDLAPRVSELAALKRQCAQLEADTESENQRARTLEVSREGSVYKLRLSVRALELEIDNLKTQAIVTDKKAELLRLELEQADNVREFDRLKREITSENNACKTQMMEIRAKQEELKCNLPNRMAQNKLFKSLVSILEFRKQAALERQEDHAAEMRMDKIRITN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0031503 (protein-containing complex localization), GO:0007017 (microtubule-based process), GO:0042073 (intraciliary transport), GO:0007018 (microtubule-based movement), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0010970 (transport along microtubule), GO:0030030 (cell projection organization), GO:0006996 (organelle organization), GO:0099111 (microtubule-based transport), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0097228 (sperm principal piece), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)