Protein: Toll-like receptor (A6JDF8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR017241: Toll-like receptor (family) [31-794]
- IPR035897: Toll/interleukin-1 receptor homology (TIR) domain superfamily (homologous_superfamily) [641-797]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [86-507]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [44-598]
- IPR000157: Toll/interleukin-1 receptor homology (TIR) domain (domain) [651-795]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [540-594]
- IPR001611: Leucine-rich repeat (repeat) [88-484]
Sequence:
MVKSLWDSLCNMSQDREPIVESFHFVCTLALIVGSMTQFSDEFESVVDYSNKNLTHVPKDLSPSTKSLSLSQNSISDLQMSDISFLSELRVLRLSHNRIRRLDFGVFLLNRDLEYLDVSHNQLQNISCCPMVNLKHLDLSFNDFEVLPVYKEFGNLMKLSFLGLSAAKFRQLDLLPISHLHLSCVLLDLVNYQIKDGETESLQVPNTNVLHLVFHPNSLFSVQVNISVNALGCLQLSNIKLNDKNCQSLIIFLSELTRGPTLLNLTLQHIETNWKCFVRLLQFLWPRPVEYLNIYNLTITESISRETFIYVETVLKSLKIEHVTNQVFLFVKDALYSVFAEMNIRMLTLSDTPFIHMVCPEFPSTFAFLNFTQNVFTDSIFQGCSTLKRLETLILQRNGLKNLFKVALMTKTMSSLETLDVSLNSLNSHVYDRTCAWAESIRVLNLSSNVLSDSVFRCLPPKVKVLDLHNNRIVSIPKDVTHLQALQELNVASNFLTDLPGCGAFSSLSVLVIDHNSVSHPSSDFFQSCQNIRSITAGNNPFRCTCELREFVKNIGQASREVVEGWPDSYRCDYPDSIKGTPLQDFHMSPLSCDTILLTVTIGATLLLLAAIGASLCLYFDLPWYLRMLWQWTQTRHRARNIPLEELQRNLQFHAFVSYSEHDSAWVKNELLPNLEKDDIRVCLHERNFVPGKSIVENIIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPIQQNNIPSRYHKLRALMAQRTYLEWPIEKGKRGLFWANLRASFIMKLALVNENDVKT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0008289 (lipid binding), GO:0042277 (peptide binding), GO:0004888 (transmembrane signaling receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0001775 (cell activation), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0048584 (positive regulation of response to stimulus), GO:0006955 (immune response), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0002682 (regulation of immune system process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0002253 (activation of immune response), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0002764 (immune response-regulating signaling pathway), GO:0032103 (positive regulation of response to external stimulus), GO:0043207 (response to external biotic stimulus), GO:0002269 (leukocyte activation involved in inflammatory response), GO:0080134 (regulation of response to stress), GO:0006952 (defense response), GO:0032101 (regulation of response to external stimulus), GO:0061900 (glial cell activation), GO:0010033 (response to organic substance), GO:0002218 (activation of innate immune response), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:2001057 (reactive nitrogen species metabolic process), GO:0002833 (positive regulation of response to biotic stimulus), GO:0009617 (response to bacterium), GO:0050778 (positive regulation of immune response), GO:0002274 (myeloid leukocyte activation), GO:0031349 (positive regulation of defense response), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0002758 (innate immune response-activating signaling pathway), GO:0045088 (regulation of innate immune response), GO:0042116 (macrophage activation), GO:0002237 (response to molecule of bacterial origin), GO:0006954 (inflammatory response), GO:0001774 (microglial cell activation), GO:0046209 (nitric oxide metabolic process), GO:0002221 (pattern recognition receptor signaling pathway), GO:0150076 (neuroinflammatory response), GO:0002224 (toll-like receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)