Protein: receptor protein-tyrosine kinase (A6JW54)
Organism: Rattus norvegicus (Rat)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Early endosome. Endosome. Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR003961: Fibronectin type III (domain) [328-537]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [742-754]
- IPR050449: Ephrin receptor tyrosine kinases (family) [14-908]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [621-878]
- IPR000719: Protein kinase domain (domain) [621-882]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [328-543]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [328-532]
- IPR034270: Ephrin type-A receptor 4, ligand binding domain (domain) [30-203]
- IPR027936: Ephrin receptor, transmembrane domain (domain) [550-618]
- IPR016257: Ephrin receptor type-A /type-B (family) [14-908]
- IPR008979: Galactose-binding-like domain superfamily (homologous_superfamily) [30-203]
- IPR001426: Tyrosine-protein kinase, receptor class V, conserved site (conserved_site) [185-267]
- IPR017441: Protein kinase, ATP binding site (binding_site) [627-653]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [621-878]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [613-899]
- IPR001090: Ephrin receptor ligand binding domain (domain) [30-209]
Sequence:
MAGIFYFILFSFLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEASQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRESQFGKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGHEEQNGECQACKIGYYKALSTDATCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTRVSITDLLAHTNYTFEIWAVNGVSKYNPSPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSQAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGPESSRPNTALLDPSSYGILRRSISG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0046875 (ephrin receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0007275 (multicellular organism development), GO:0065009 (regulation of molecular function), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0050773 (regulation of dendrite development), GO:0050790 (regulation of catalytic activity), GO:0045597 (positive regulation of cell differentiation), GO:0070570 (regulation of neuron projection regeneration), GO:2000026 (regulation of multicellular organismal development), GO:0051129 (negative regulation of cellular component organization), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0080135 (regulation of cellular response to stress), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0032101 (regulation of response to external stimulus), GO:0050803 (regulation of synapse structure or activity), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:1903035 (negative regulation of response to wounding), GO:0070571 (negative regulation of neuron projection regeneration), GO:0016477 (cell migration), GO:0032102 (negative regulation of response to external stimulus), GO:0048681 (negative regulation of axon regeneration), GO:0048679 (regulation of axon regeneration), GO:0022604 (regulation of cell morphogenesis), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0050807 (regulation of synapse organization), GO:0031344 (regulation of cell projection organization), GO:1903034 (regulation of response to wounding), GO:0031346 (positive regulation of cell projection organization), GO:0051336 (regulation of hydrolase activity), GO:0060284 (regulation of cell development), GO:0008347 (glial cell migration), GO:0010720 (positive regulation of cell development), GO:0048814 (regulation of dendrite morphogenesis), GO:0050769 (positive regulation of neurogenesis), GO:0051960 (regulation of nervous system development), GO:0031345 (negative regulation of cell projection organization), GO:0043087 (regulation of GTPase activity), GO:0010770 (positive regulation of cell morphogenesis involved in differentiation), GO:0010769 (regulation of cell morphogenesis involved in differentiation), GO:0042063 (gliogenesis), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0010977 (negative regulation of neuron projection development), GO:0050767 (regulation of neurogenesis), GO:0050775 (positive regulation of dendrite morphogenesis), GO:1905806 (regulation of synapse pruning), GO:1905244 (regulation of modification of synaptic structure), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043204 (perikaryon), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0030427 (site of polarized growth), GO:0098793 (presynapse), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0044306 (neuron projection terminus), GO:0043198 (dendritic shaft), GO:0031975 (envelope), GO:0098794 (postsynapse), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043679 (axon terminus), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0019867 (outer membrane), GO:0005794 (Golgi apparatus), GO:0043025 (neuronal cell body), GO:0043197 (dendritic spine), GO:0005739 (mitochondrion), GO:0005783 (endoplasmic reticulum), GO:0097447 (dendritic tree), GO:0030426 (growth cone), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0098858 (actin-based cell projection), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0014069 (postsynaptic density), GO:0031594 (neuromuscular junction), GO:0044295 (axonal growth cone), GO:0098978 (glutamatergic synapse), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0098984 (neuron to neuron synapse), GO:0031968 (organelle outer membrane), GO:0031966 (mitochondrial membrane), GO:0032279 (asymmetric synapse), GO:0005741 (mitochondrial outer membrane), GO:0030175 (filopodium), GO:0030424 (axon), GO:0044309 (neuron spine)