lokahq/bioreason-rl huggingface dataset:
Protein: WNK lysine deficient protein kinase 1 (A0A6Q8PFM0)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR056865: Serine/threonine-protein kinase WNK, CCTL2 domain (domain) [267-341]
- IPR050588: With No Lysine (K) Ser/Thr Protein Kinase (family) [90-1278]
Sequence:
EQEKKKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSSQQTVSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQSTQGVSQVAPAEPVAVAQTQATQPTTLASSVDSAHSDVASGMSDGNENVPSSSGRHEGRTTKRHYRKSVRSRSRHEKTSRPKLRILNVSNKGDRVVECQLETHNRKMVTFKFDLDGDNPEEIATIMVNNDFILAIERESFVDQVREIIEKADEMLSEDVSVEPEGDQGLESLQGKDDYGFSGSQKLEGEFKQPIPASSMPQQIGIPTSSLTQVVHSAGRRFIVSPVPESRLRESKVFPSEITDTVAASTAQSPGMNLSHSASSLSLQQAFSELRRAQMTEGPNTAPPNFSHTGPTFPVVPPFLSSIAGVPTTAAATAPVPATSSPPNDISTSVIQSEVTVPTEEGIAGVATSTGVVTSGGLPIPPVSESPVLSSVVSSITIPAVVSISTTSPSLQVPTSTSEIVVSSTALYPSVTVSATSASAGGSTATPGPKPPAVVSQQAAGSTTVGATLTSVSTTTSFPSTASQLCIQLSSSTSTPTLAETVVVSAHSLDKTSHSSTTGLAFSLSAPSSSSSPGAGVSSYISQPGGLHPLVIPSVIASTPILPQAAGPTSTPLLPQVPSIPPLVQPVANVPAVQQTLIHSQPQPALLPNQPHTHCPEVDSDTQPKAPGIDDIKTLEEKLRSLFSEHSSSGAQHASVSLETSLVIESTVTPGIPTTAVAPSKLLTSTTSTCLPPTNLPLGTVALPVTPVVTPGQVSTPVSTTTSGVKPGTAPSKPPLTKAPVLPVGTELPAGTLPSEQLPPFPGPSLTQSQQPLEDLDAQLRRTLSPEMITVTSAVGPVSMAAPTAITEAGTQPQKGVSQVKEGPVLATSSGAGVFKMGRFQVSVAADGAQKEGKNKSEDAKSVHFESSTSESSVLSSSSPESTLVKPEPNGITIPGISSDVPESAHKTTASEAKSDTGQPTKVGRFQVTTTANKVGRFSVSKTEDKITDTKKEGPVASPPFMDLEQAVLPAVIPKKEKPELSEPSHLNGPSSDPEAAFLSRDVDDGSGSPHSPHQLSSKSLPSQNLSQSLSNSFNSSYMSSDNESDIEDEDLKLELRRLRDKHLKEIQDLQSRQKHEIESLYTKLGKVPPAVIIPPAAPLSGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQSAASVLHPQQTLHPPGNIPESGQNQLLQPLKPSPSSDNLYSAFTSDGAISVPSLSAPGQGTSSTNTVGATVNSQAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLSGRRGSKGHMNYEGPGMARKFSAPGQLCISMTSNLGGSAPISAASATSLGHFTKSMCPPQQYGFPATPFGAQWSGTGGPAPQPLGQFQPVGTASLQNFNISNLQKSISNPPGSNLRTT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0051050 (positive regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0060627 (regulation of vesicle-mediated transport), GO:0051130 (positive regulation of cellular component organization), GO:0051049 (regulation of transport), GO:0045807 (positive regulation of endocytosis), GO:0051128 (regulation of cellular component organization), GO:0030100 (regulation of endocytosis), GO:0048260 (positive regulation of receptor-mediated endocytosis), GO:0048259 (regulation of receptor-mediated endocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Sorting nexin 14 (A0A804HKC6)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR037436: Sorting nexin-14, PX domain (domain) [563-685]
- IPR001683: Phox homology (domain) [566-689]
- IPR003114: Phox-associated domain (domain) [129-303]
- IPR013937: Sorting nexin, C-terminal (domain) [806-909]
- IPR036305: RGS domain superfamily (homologous_superfamily) [327-472]
- IPR036871: PX domain superfamily (homologous_superfamily) [556-701]
- IPR044926: RGS, subdomain 2 (homologous_superfamily) [322-477]
- IPR037892: SNX14, RGS domain (domain) [339-465]
- IPR016137: RGS domain (domain) [335-467]
Sequence:
MVPWVRTMGQKLKQRLRLDVGREICRQYPLFCFLLLCLSAASLLLNRYIHILMIFWSFVAGVVTFYCSLGPDSLLPNIFFTIKYKPKLGLQELFPQGHSCAVCGKVKCKRHRPSLLLENYQPWLDLKISSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDELRITLRFFASVLIRRIHKVDIPSIITKKLLKAAMKHIEVIVKARQKVKNTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLIREILSGSVFLPSLDFLADPDTVNHLLIIFIDDSPPEKATEPASPLVPFLQKFAEPRNKKPSVLKLELKQIREQQDLLFRFMNFLKQEGAVHVLQFCLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESIDKIRFDPFIVEEIQRIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKLNRGSLSLDDFRNTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGVAEGEDDFIEEGIVVMEDDSPVEAVSTPNTPRNLAAWKISIPYVDFFEDPSSERKEKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGAFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIMNFINSCESPKPKPSRPELTILSPTSENNKKLFNDLFKNNANRAENTERKQNQNYFMEVMTVEGVYDYLMYVGRVVFQVPDWLHHLLMGTRILFKNTLEMYTDYYLQCKLEQLFQEHRLVSLITLLRDAIFCENTEPRSLQDKQKGAKQTFEEMMNYIPDLLVKCIGEETKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPELNKVQKEVTSVTSWM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0008289 (lipid binding), GO:0043168 (anion binding), GO:0005543 (phospholipid binding), GO:0080025 (phosphatidylinositol-3,5-bisphosphate binding), GO:0035091 (phosphatidylinositol binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:1902936 (phosphatidylinositol bisphosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0016043 (cellular component organization), GO:0044248 (cellular catabolic process), GO:0006914 (autophagy), GO:0016236 (macroautophagy), GO:0022411 (cellular component disassembly), GO:0043933 (protein-containing complex organization), GO:0097352 (autophagosome maturation), GO:0032984 (protein-containing complex disassembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Alpha-crystallin A chain (A0A8C8KJZ9)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR002068: Alpha crystallin/Hsp20 domain (domain) [16-127]
- IPR001436: Alpha crystallin/Small heat shock protein, animal type (family) [26-135]
- IPR008978: HSP20-like chaperone (homologous_superfamily) [17-135]
Sequence:
MPVCPGDSHRPPKALPHLVCGRRGRQVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0051082 (unfolded protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051239 (regulation of multicellular organismal process), GO:0019222 (regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0001818 (negative regulation of cytokine production), GO:0001817 (regulation of cytokine production), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0032675 (regulation of interleukin-6 production), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Mitochondrial S-adenosylmethionine carrier protein (A0A8I5QKW7)
Organism: Homo sapiens (Human)
Function: Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L- homocysteine antiporter. Mediates the exchange of cytosolic S-adenosyl- L-methionine, the predominant methyl-group donor for macromolecule methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a by-product of methylation reactions
Subcellular location: Membrane; Multi- pass membrane protein
InterPro domains:
- IPR018108: Mitochondrial carrier protein, transmembrane region (repeat) [4-178]
- IPR023395: Mitochondrial carrier protein domain superfamily (homologous_superfamily) [5-185]
Sequence:
MDRPGFVAALVVACLIRVPSEVVKQRAQVSASTRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRITLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYDRTHSLLLEVGRKSP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015175 (neutral L-amino acid transmembrane transporter activity), GO:0015179 (L-amino acid transmembrane transporter activity), GO:0015187 (glycine transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0006810 (transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: MAM domain containing glycosylphosphatidylinositol anchor 1 (A0A7P0TB21)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR003961: Fibronectin type III (domain) [387-487]
- IPR050958: Cell Adhesion and Cytoskeletal Organization (family) [2-518]
- IPR000998: MAM domain (domain) [484-591]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [1-483]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [399-484]
- IPR003598: Immunoglobulin subtype 2 (domain) [2-366]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [487-580]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [2-375]
- IPR007110: Immunoglobulin-like domain (domain) [1-375]
- IPR003599: Immunoglobulin domain subtype (domain) [1-377]
Sequence:
MLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEHNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIVHRKHLHCFPQP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0030155 (regulation of cell adhesion), GO:0050803 (regulation of synapse structure or activity), GO:0051128 (regulation of cellular component organization), GO:0044087 (regulation of cellular component biogenesis), GO:0050807 (regulation of synapse organization), GO:1901888 (regulation of cell junction assembly), GO:0022407 (regulation of cell-cell adhesion), GO:0051963 (regulation of synapse assembly), GO:0099174 (regulation of presynapse organization), GO:1905606 (regulation of presynapse assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Interferon induced transmembrane protein 2 (R4GNC9)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR051517: Interferon-induced transmembrane antiviral protein (family) [2-62]
- IPR007593: CD225/Dispanin family (family) [34-62]
Sequence:
MLKEEQEVAMLGVPHNPAPPMSTVIHIRSETSVPDHVVWSLFNTLFMNTCCLGFIAFAYSVKEDGWRRDRGPGLCLHRQVPEHLGPDFGHLHDHSAHHHPSVGRPGPAIDQEASLRPGALPVTCIPRTLSSIPRPAPRGQELCP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0043903 (regulation of biological process involved in symbiotic interaction), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0051716 (cellular response to stimulus), GO:0050792 (regulation of viral process), GO:0006950 (response to stress), GO:0048525 (negative regulation of viral process), GO:0051707 (response to other organism), GO:0045069 (regulation of viral genome replication), GO:1903900 (regulation of viral life cycle), GO:0043207 (response to external biotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0006952 (defense response), GO:0045071 (negative regulation of viral genome replication), GO:0052372 (modulation by symbiont of entry into host), GO:0009615 (response to virus), GO:1903901 (negative regulation of viral life cycle), GO:0010033 (response to organic substance), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0046596 (regulation of viral entry into host cell), GO:0034097 (response to cytokine), GO:0071310 (cellular response to organic substance), GO:0034341 (response to type II interferon), GO:0046597 (negative regulation of viral entry into host cell), GO:0035456 (response to interferon-beta), GO:0035455 (response to interferon-alpha), GO:0071345 (cellular response to cytokine stimulus), GO:0035458 (cellular response to interferon-beta)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Muscleblind like splicing regulator 3 (B1AKI2)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR000571: Zinc finger, CCCH-type (domain) [7-194]
- IPR054429: Muscleblind-like, CCCH zinc finger (domain) [17-206]
Sequence:
IKGRCSREKCKYFHPPAHLQARLKAAHHQMNHSAASAMALQPGTLQLIPKRSALEKPNGATPVFNPTVFHCQQALTNLQLPQPAFIPAGPILCMAPASNIVPMMHGATPTTVSAATTPATSVPFAAPTTGNQIPQLSIDELNSSMFVSQM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010468 (regulation of gene expression), GO:0043484 (regulation of RNA splicing), GO:1903311 (regulation of mRNA metabolic process), GO:0050684 (regulation of mRNA processing), GO:0048024 (regulation of mRNA splicing, via spliceosome), GO:0000381 (regulation of alternative mRNA splicing, via spliceosome)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Dymeclin (A0A6Q8PF81)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR019142: Dymeclin (family) [1-722]
Sequence:
MGSNSSRIGDLPKNEYLKKLSGTESISENDPFWNQLLSFSFPAPTSSSELKLLEEATISVCRSLVENNPRTGNLGALIKVFLSRTKELKLSAECQNHIFIWQTHNALFIICCLLKVFICQMSEEELQLHFTYEEKSPGNYSSDSEDLLEELLCCLMQLITDIPLLDITYEISVEAISTMVVFLSCQLFHKEVLRQSISHKYLMRGPCLPYTSKLVKTLLYNFIRQEKPPPPGAHVFPQQSDGGGLLYGLASGVATGLWTVFTLGGVGSKAAASPELSSPLANQSLLLLLVLANLTDASDAPNPYRQAIMSFKNTQDSSPFPSSIPHAFQINFNSLYTALCEQQTSDQATLLLYTLLHQNSNIRTYMLARTDMENLVLPILEILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVILKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIISYTCRHLRRYVYVLDKLYFPHSHCSTLQHCFSTLSDNGEELLSLTCSHILRSYASSLFSLLSKKHNKVLEQATQSLRGSLSSNDVPLPDYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKFPELKFKYVEEEQPEEFFIPYVWSLVYNSAVGLYWNPQDIQLFTMDSD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0016043 (cellular component organization), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0001501 (skeletal system development), GO:0006996 (organelle organization), GO:0010256 (endomembrane system organization), GO:0060348 (bone development), GO:0007030 (Golgi organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Drebrin-like protein variant (Q59FH4)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, dendrite. Cell projection, lamellipodium. Cell projection, neuron projection. Cell projection, podosome. Cell projection, ruffle. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Endosome. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Postsynaptic density. Synapse
InterPro domains:
- IPR001452: SH3 domain (domain) [299-358]
- IPR035717: Drebrin-like protein, SH3 domain (domain) [303-356]
- IPR029006: ADF-H/Gelsolin-like domain superfamily (homologous_superfamily) [6-69]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [301-357]
- IPR002108: Actin-depolymerising factor homology domain (domain) [1-61]
Sequence:
ATAMTSAWLAQGTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding), GO:0008047 (enzyme activator activity), GO:0045296 (cadherin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0030036 (actin cytoskeleton organization), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0034330 (cell junction organization), GO:0098974 (postsynaptic actin cytoskeleton organization), GO:0099173 (postsynapse organization), GO:0007010 (cytoskeleton organization), GO:0050808 (synapse organization), GO:0099188 (postsynaptic cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle)