Protein: Caspase-8 (E7EVN1)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR011029: Death-like domain superfamily (homologous_superfamily) [1-124]
- IPR001875: Death effector domain (domain) [1-124]
- IPR033170: Caspase-8, death effector domain 1 (domain) [3-84]
Sequence:
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048519 (negative regulation of biological process), GO:0023057 (negative regulation of signaling), GO:0019222 (regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050790 (regulation of catalytic activity), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0060548 (negative regulation of cell death), GO:0044092 (negative regulation of molecular function), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0043086 (negative regulation of catalytic activity), GO:0043069 (negative regulation of programmed cell death), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:0051336 (regulation of hydrolase activity), GO:0051248 (negative regulation of protein metabolic process), GO:2001234 (negative regulation of apoptotic signaling pathway), GO:2001233 (regulation of apoptotic signaling pathway), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0042981 (regulation of apoptotic process), GO:0051346 (negative regulation of hydrolase activity), GO:0030162 (regulation of proteolysis), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:0052547 (regulation of peptidase activity), GO:0043066 (negative regulation of apoptotic process), GO:0019220 (regulation of phosphate metabolic process), GO:0045861 (negative regulation of proteolysis), GO:0045936 (negative regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0052548 (regulation of endopeptidase activity), GO:0010466 (negative regulation of peptidase activity), GO:0042326 (negative regulation of phosphorylation), GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:2000116 (regulation of cysteine-type endopeptidase activity), GO:0010951 (negative regulation of endopeptidase activity), GO:2000117 (negative regulation of cysteine-type endopeptidase activity), GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)