Protein: Phosphate regulating gene with homologies to endopeptidases on the X chromosome (Hypophosphatemia, vitamin D resistant rickets), isoform CRA_a (A6IPQ1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single- pass type II membrane protein
InterPro domains:
- IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [54-749]
- IPR000718: Peptidase M13 (family) [32-749]
- IPR008753: Peptidase M13, N-terminal domain (domain) [76-479]
- IPR042089: Peptidase M13, domain 2 (homologous_superfamily) [102-525]
- IPR018497: Peptidase M13, C-terminal domain (domain) [530-742]
Sequence:
MEAEAGSTMETGKGTNRGIRIALALFITGTLVLGTLLFLVSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALLEKSVSRRRDTEAVQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAVLAKVGYPEFIMNDTYVNEDLKAIKFSESDYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSVDSEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPANSTMNRGADSCRLW
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0043169 (cation binding), GO:0008233 (peptidase activity), GO:0046872 (metal ion binding), GO:0004175 (endopeptidase activity), GO:0008237 (metallopeptidase activity), GO:0046914 (transition metal ion binding), GO:0004222 (metalloendopeptidase activity), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0035295 (tube development), GO:0009991 (response to extracellular stimulus), GO:0010035 (response to inorganic substance), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0031668 (cellular response to extracellular stimulus), GO:0071496 (cellular response to external stimulus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1902074 (response to salt), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0030324 (lung development), GO:0030323 (respiratory tube development), GO:0032870 (cellular response to hormone stimulus), GO:0060348 (bone development), GO:0010243 (response to organonitrogen compound), GO:0001501 (skeletal system development), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0031670 (cellular response to nutrient), GO:0014070 (response to organic cyclic compound), GO:0033273 (response to vitamin), GO:0071107 (response to parathyroid hormone), GO:1901701 (cellular response to oxygen-containing compound), GO:0031669 (cellular response to nutrient levels), GO:0033280 (response to vitamin D), GO:0060541 (respiratory system development), GO:0071305 (cellular response to vitamin D), GO:0071295 (cellular response to vitamin), GO:0071374 (cellular response to parathyroid hormone stimulus), GO:0060416 (response to growth hormone), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)