Protein: Neurofibromin isoform X2 (A0A8M2BH35)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR036865: CRAL-TRIO lipid binding domain superfamily (homologous_superfamily) [1475-1620]
- IPR001936: Ras GTPase-activating domain (domain) [1102-1451]
- IPR023152: Ras GTPase-activating protein, conserved site (conserved_site) [1301-1315]
- IPR008936: Rho GTPase activation protein (homologous_superfamily) [1113-1443]
- IPR016024: Armadillo-type fold (homologous_superfamily) [642-1384]
- IPR039360: Ras GTPase-activating protein (family) [57-1884]
- IPR001251: CRAL-TRIO lipid binding domain (domain) [1474-1632]
- IPR054071: Neurofibromin, PH domain-like (domain) [1631-1725]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [1621-1731]
Sequence:
MAAQKPVEWVQAVISRFDEQLPVKVGVQNTHTKISTEHNKECLINISRYKFSLVISGLTNILKNVNNMRIFGDTAERNLYLSQLIILDTLEKCLAGQPKDSMRLDETMLVKQLLPEICHFIHTYREGNQHAAELRSSACGVLFSLSCSNFNAVFSRISTRLQELTVCSEDTVDVHDIELIQYINVDGCKLKRLLQETVFKFKALKKPAQLSVIFNLEKAFWNWVENYPDEFTRLYQRPQTDMADCAEKLFDLVDSFAESTKRKAAVWPLQIILLILCPDITQDMSRDAAEDAKDNKKLFLENLRKALTGHGGSKQLTESAAIACVKLCKASTYISWEDHSVIFLLVQSIVMDLKGLLFNPVKPFSRGAGSQSADLDLMIDCFVSCFRINPHNNQQFKVCLASSSPSTFHFVLVNSLHRIITNSPLDWWPKIDTVYCYSGELRLMFAETLGRVVQGCSHTTLRLTPSLTFKEKMSSLKFKEKTTDLDTRSLKYLLLALVKLIHADPKLMLHNPGKQGLEVHSSTAELITGLVQLVPLANMGEISQEAMEALLVLHQPESIELWNPDAPMETFWDISSQVLYFICKNLFGHPLVSSTEILKWLREILICRNKFLLRNKDRATVGSNIATCRQAQTKLEVCLYMFLWSPDMEAVLVAMSCFRYLCEEAEIRCGVEDIPVQSLLPNYNTFMEFASVSNMMVTGRSALQKRVMALLRKIELPTPGNTEAWEDTHAKWEHATKLILSHPKTKLEDGQEWINMTGFLCALGGVCLQQRHVSALATYSPPMGTLNDRKGSMVSMSSCEGSPETPLGRFLDRLLSLMVCSHEKGHQIRTNVKDLVGLELSPVLYPMLFNKLKNSISRFFDAQGPVPINETNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRILGNMVHAIQIKTKLCQLVEVMMERRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDEGQPVVGRKRGMSRRLASLRHCTILAMSNLLSANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETALADRFERLVELVTMMGDQGELPIAMALASVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLEPLLRSVIAGTEWHMLSFEVDPTRLENGENLEENQRNLLRMTERFFKAIISSSGEFPPQLRSVCHCLFQVVSQRFPQNSIGAVGSAMFLRFVNPAIVSPYEAGILDKKPQPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPASDSLNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLHIFYQAGTSKNGNPVFYYVTRRFKTGQINGDLLIYHVLLTLKPYYAKPYELVVDLTHAGPSNRFKTDFLSKWFVVFPGFAYENVAAIYIYNCNTWVREYTKYHERLLTGLKGSKKLLFIDSPARLAEHVEPEQQKLPAATLALEEDLKVFHNALKLAHRDTKVSIKVGSTAVQVTSAERTRVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECESIVHSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISQTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLLNLVRFCKHSDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIIRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTLLVATGPLSLRASTHGLVINIIHSLCTCSQLSFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALSSLETVTEALLEIMEACMRDIPGCKWLDQWTDLAQKFAFQYNPSLQPRALVVFGCISKRVTHTQMKQIIRILSKASLLLSIDRGLESCLKGPDNCNSQVLIEATVIALTKLQPLLNKDSAMHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRVFNDKSPEEVFMEIRQPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGFRHPSPTTVARTIRILHMLLALVGKHQNCDKFEVNTQSVAYLAALLPVSEEVRSRCSLKHRKLLLFSDVTMENVQMDPYSVHHEDPSGRTLRENELWASPKVSERYLVAHFPIMGQISPRTRKSMSLDMGQPSQVNTKKLLGTRKSFDLLLSDSKAPKRPEIETGITTPPKMRRVAENEYEIETPRISHHHLRKVSVSESNVLLNEEVLTDPKIQALLLTVLATQVKNTSDEFEQRILYEFLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPHLLNPVHGIVQSVVYHEESPPQYQPSYLQTFGFNGLWRFAGPFSKQTQFPDYAELIVKFLDALIDTYLPGIDEETSEEGLRTPTSPYPPPVQSQLSITANLNLSNSMTSLATSQHAPGMDKEKVDLSPTTGLAAGGRTRHGSASQVQKQRSTGSFKRPSIKKIV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0023057 (negative regulation of signaling), GO:0008283 (cell population proliferation), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0003008 (system process), GO:0007610 (behavior), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0061351 (neural precursor cell proliferation), GO:0042127 (regulation of cell population proliferation), GO:0001568 (blood vessel development), GO:0010646 (regulation of cell communication), GO:0007611 (learning or memory), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0045595 (regulation of cell differentiation), GO:0050877 (nervous system process), GO:0007613 (memory), GO:0050890 (cognition), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0060251 (regulation of glial cell proliferation), GO:0007612 (learning), GO:1902532 (negative regulation of intracellular signal transduction), GO:0045685 (regulation of glial cell differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:0007507 (heart development), GO:0043408 (regulation of MAPK cascade), GO:0042063 (gliogenesis), GO:0046958 (nonassociative learning), GO:0043409 (negative regulation of MAPK cascade), GO:0070373 (negative regulation of ERK1 and ERK2 cascade), GO:0046959 (habituation), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0045202 (synapse), GO:0098978 (glutamatergic synapse)