Protein: 5-aminolevulinate synthase, non-specific, mitochondrial (Q8VC19)
Organism: Mus musculus (Mouse)
Function: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products
Subcellular location: Mitochondrion inner membrane ; Peripheral membrane protein . Note=Localizes to the matrix side of the mitochondrion inner membrane
InterPro domains:
- IPR015421: Pyridoxal phosphate-dependent transferase, major domain (homologous_superfamily) [263-496]
- IPR015424: Pyridoxal phosphate-dependent transferase (homologous_superfamily) [199-599]
- IPR004839: Aminotransferase, class I/classII, large domain (domain) [248-592]
- IPR050087: 8-amino-7-oxononanoate synthase class-II (family) [197-592]
- IPR010961: Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase (domain) [199-603]
- IPR001917: Aminotransferase, class-II, pyridoxal-phosphate binding site (binding_site) [444-453]
- IPR015422: Pyridoxal phosphate-dependent transferase, small domain (homologous_superfamily) [245-585]
- IPR015118: 5-aminolevulinate synthase presequence (domain) [2-140]
Sequence:
METVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRTLSTSAVHCQQVKETPPANEKEKTAKAAVQQAPDESQMAQTPDGTQLPSGHPSPATSQGSGSKCPFLAAQLSQTGSSVFRKASLELQEDVQEMHAVRKEAAQSPVPPSLVNVKTDGEDPSRLLKNFQDIMRKQRPERVSHLLQDNLPKSVSTFQYDHFFEKKIDEKKNDHTYRVFKTVNRRAQIFPMADDYTDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMETVKQHGAGAGGTRNISGTSKFHVELEQALADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVNHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSLLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSSEGRALRRQHQRNVKLLRQMLMDAGLPVIHCPSHIIPVRVADAAKNTEICDELMTRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNFFVEKLLVTWKRVGLELKPHSSAECNFCRRPLHFEVMSEREKAYFSGMSKMVSAQA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048878 (chemical homeostasis), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009058 (biosynthetic process), GO:0019725 (cellular homeostasis), GO:0044237 (cellular metabolic process), GO:0042440 (pigment metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0002262 (myeloid cell homeostasis), GO:0044238 (primary metabolic process), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0034101 (erythrocyte homeostasis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0019538 (protein metabolic process), GO:0046148 (pigment biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0098771 (inorganic ion homeostasis), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0042168 (heme metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0048872 (homeostasis of number of cells), GO:1901566 (organonitrogen compound biosynthetic process), GO:0030097 (hemopoiesis), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0055080 (monoatomic cation homeostasis), GO:0030218 (erythrocyte differentiation), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0020027 (hemoglobin metabolic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0030099 (myeloid cell differentiation), GO:0033013 (tetrapyrrole metabolic process), GO:0006783 (heme biosynthetic process), GO:0055072 (iron ion homeostasis), GO:0006778 (porphyrin-containing compound metabolic process), GO:0033014 (tetrapyrrole biosynthetic process), GO:0042541 (hemoglobin biosynthetic process), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0006779 (porphyrin-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)