Protein: Essential MCU regulator, mitochondrial (Q7JX57)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential regulatory subunit of the mitochondrial calcium uniporter MCU channel, a protein that mediates calcium uptake into mitochondria
Subcellular location: Mitochondrion inner membrane ; Single-pass membrane protein
InterPro domains:
- IPR018782: Essential MCU regulator, mitochondrial (family) [17-96]
Sequence:
MIVPRLALPISLALQRVSRRVAEHPHNLRILQRHMSSVYFRSGAIKPKPEEMPFGLLAIFCAVIPGLFVGATISKNVANFLEENDLFVPADDDDDED
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0016247 (channel regulator activity), GO:0099106 (ion channel regulator activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005246 (calcium channel regulator activity), GO:0005261 (monoatomic cation channel activity), GO:0005262 (calcium channel activity), GO:0046873 (metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0055085 (transmembrane transport), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0002684 (positive regulation of immune system process), GO:0051234 (establishment of localization), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0050776 (regulation of immune response), GO:0043207 (response to external biotic stimulus), GO:0002833 (positive regulation of response to biotic stimulus), GO:0098660 (inorganic ion transmembrane transport), GO:0080134 (regulation of response to stress), GO:0009617 (response to bacterium), GO:0006810 (transport), GO:0006952 (defense response), GO:1990542 (mitochondrial transmembrane transport), GO:0050778 (positive regulation of immune response), GO:0032101 (regulation of response to external stimulus), GO:0098771 (inorganic ion homeostasis), GO:0034220 (monoatomic ion transmembrane transport), GO:0031349 (positive regulation of defense response), GO:0098542 (defense response to other organism), GO:0098655 (monoatomic cation transmembrane transport), GO:0031347 (regulation of defense response), GO:0006851 (mitochondrial calcium ion transmembrane transport), GO:0045089 (positive regulation of innate immune response), GO:0098662 (inorganic cation transmembrane transport), GO:0055080 (monoatomic cation homeostasis), GO:0045088 (regulation of innate immune response), GO:0042742 (defense response to bacterium), GO:0071702 (organic substance transport), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0055074 (calcium ion homeostasis), GO:0070588 (calcium ion transmembrane transport), GO:0050829 (defense response to Gram-negative bacterium), GO:0006812 (monoatomic cation transport), GO:0006816 (calcium ion transport), GO:0006874 (intracellular calcium ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:0051560 (mitochondrial calcium ion homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)