Protein: Adenylosuccinate synthetase isozyme 1 (A6KBV5)
Organism: Rattus norvegicus (Rat)
Function: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP
Subcellular location: Cytoplasm
InterPro domains:
- IPR033128: Adenylosuccinate synthase, active site (active_site) [166-177]
- IPR042109: Adenylosuccinate synthetase, domain 1 (homologous_superfamily) [35-297]
- IPR027509: Adenylosuccinate synthetase isozyme 1, chordates (family) [1-457]
- IPR042111: Adenylosuccinate synthetase, domain 3 (homologous_superfamily) [298-457]
- IPR042110: Adenylosuccinate synthetase, domain 2 (homologous_superfamily) [132-231]
- IPR001114: Adenylosuccinate synthetase (family) [1-457]
- IPR018220: Adenylosuccinate synthase, GTP-binding site (binding_site) [40-47]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [32-455]
Sequence:
MSGTRASNDRPPGTGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVVDLLATDADIVSRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLVFDFHQAVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDFDEFSARFKNLAHQHQSMFPTLEIDVEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGDLLQNRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLSEIKVGISYKLNGKRIPYFPANQEILQKVEVEYETLPGWKADTTGARKWEDLPPQAQSYVRFVENHLGVAVKWVGVGKSRESMIQLF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0016787 (hydrolase activity), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0051015 (actin filament binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0042802 (identical protein binding), GO:0016879 (ligase activity, forming carbon-nitrogen bonds), GO:0008092 (cytoskeletal protein binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0003779 (actin binding), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0014823 (response to activity), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044238 (primary metabolic process), GO:0051602 (response to electrical stimulus), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0009410 (response to xenobiotic stimulus), GO:0046483 (heterocycle metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0009991 (response to extracellular stimulus), GO:1901360 (organic cyclic compound metabolic process), GO:0104004 (cellular response to environmental stimulus), GO:0014850 (response to muscle activity), GO:0042594 (response to starvation), GO:0006139 (nucleobase-containing compound metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0071214 (cellular response to abiotic stimulus), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0071466 (cellular response to xenobiotic stimulus), GO:0043436 (oxoacid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0071257 (cellular response to electrical stimulus), GO:0072521 (purine-containing compound metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0031667 (response to nutrient levels), GO:0018130 (heterocycle biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0009117 (nucleotide metabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0009259 (ribonucleotide metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009123 (nucleoside monophosphate metabolic process), GO:0009066 (aspartate family amino acid metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0009124 (nucleoside monophosphate biosynthetic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0006541 (glutamine metabolic process), GO:0009161 (ribonucleoside monophosphate metabolic process), GO:0006531 (aspartate metabolic process), GO:0009126 (purine nucleoside monophosphate metabolic process), GO:0009167 (purine ribonucleoside monophosphate metabolic process), GO:0046040 (IMP metabolic process), GO:0009127 (purine nucleoside monophosphate biosynthetic process), GO:0009156 (ribonucleoside monophosphate biosynthetic process), GO:0009168 (purine ribonucleoside monophosphate biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)