Protein: Hydroxymethylglutaryl-CoA synthase (A0A8M1PIL7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA
InterPro domains:
- IPR013746: Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain (domain) [195-477]
- IPR000590: Hydroxymethylglutaryl-coenzyme A synthase, active site (active_site) [124-139]
- IPR016039: Thiolase-like (homologous_superfamily) [18-478]
- IPR013528: Hydroxymethylglutaryl-coenzyme A synthase, N-terminal (domain) [20-193]
- IPR010122: Hydroxymethylglutaryl-CoA synthase, eukaryotic (family) [20-477]
Sequence:
MIVSPFRMPGSLPAICESMWPKDVGIIAMEVYVPSQYVDQAELEEYDGVGAGKYTVGLGQARMGFCSDREDINSLCLTVVQRLMERNGLSYESVGRLEVGTETIIDKSKSTKTVLMQLFEESGNTDVEGVDTTNACYGGTAALFNAVNWVESSSWDGRYALVVAGDIAVYATGSARPTGGAGAVAMLVGPNAPLAFERGLRGTHMQHAYDFYKPDMVSEYPVVDGKLSIQCYLSALDQCYSVYKNKIHARWQREGTEGRCSLEDFGFMVFHSPYCKLVQKSLARLMLNDFLCHPSPNMESGPFSGLEAFRDVKIEDTYFDRDVEKAFMKASSELFDDKTKASLLISNQNGNMYTPSVYGCLASVLAQHTPQQLAGQRIGVFSYGSGFAATLYSIKVTQDGTPGSALDKLVSSLCDLPARLDSRQKVSPGVFAETMKLREETHHLANYIPQGSVDELFPGTWYLTRVDEKHRRQYARRSMNDDRPLEAGLVSSSMAAEHIPSPLKKMPRIPTTTAGPEVVVMSNGDH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0046912 (acyltransferase activity, acyl groups converted into alkyl on transfer)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048871 (multicellular organismal-level homeostasis), GO:0002262 (myeloid cell homeostasis), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0034101 (erythrocyte homeostasis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:1904888 (cranial skeletal system development), GO:0048872 (homeostasis of number of cells), GO:0030097 (hemopoiesis), GO:0022008 (neurogenesis), GO:0048703 (embryonic viscerocranium morphogenesis), GO:0048863 (stem cell differentiation), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0007399 (nervous system development), GO:0030218 (erythrocyte differentiation), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0021782 (glial cell development), GO:0010001 (glial cell differentiation), GO:0007417 (central nervous system development), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0030099 (myeloid cell differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0014033 (neural crest cell differentiation), GO:0061515 (myeloid cell development), GO:0043009 (chordate embryonic development), GO:0042063 (gliogenesis), GO:0048821 (erythrocyte development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0014003 (oligodendrocyte development), GO:0048709 (oligodendrocyte differentiation), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)