Protein: mitogen-activated protein kinase kinase (A6HFF9)
Organism: Rattus norvegicus (Rat)
InterPro domains:
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [107-119]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [2-267]
- IPR000719: Protein kinase domain (domain) [1-249]
Sequence:
MVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERTVEVACYVCKILDQMPATPSSPMYVD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004712 (protein serine/threonine/tyrosine kinase activity), GO:0004708 (MAP kinase kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0040007 (growth), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0016049 (cell growth), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0035265 (organ growth), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0010942 (positive regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0055017 (cardiac muscle tissue growth), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0060419 (heart growth), GO:0006793 (phosphorus metabolic process), GO:0048588 (developmental cell growth), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:1901700 (response to oxygen-containing compound), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0003012 (muscle system process), GO:0061061 (muscle structure development), GO:0010941 (regulation of cell death), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0009889 (regulation of biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0055006 (cardiac cell development), GO:0014896 (muscle hypertrophy), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:0000165 (MAPK cascade), GO:0003301 (physiological cardiac muscle hypertrophy), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:0031098 (stress-activated protein kinase signaling cascade), GO:0043412 (macromolecule modification), GO:0042692 (muscle cell differentiation), GO:0072359 (circulatory system development), GO:1902533 (positive regulation of intracellular signal transduction), GO:1901701 (cellular response to oxygen-containing compound), GO:0007507 (heart development), GO:1901216 (positive regulation of neuron death), GO:0009743 (response to carbohydrate), GO:0061049 (cell growth involved in cardiac muscle cell development), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0051052 (regulation of DNA metabolic process), GO:0071310 (cellular response to organic substance), GO:0051054 (positive regulation of DNA metabolic process), GO:0055001 (muscle cell development), GO:0043068 (positive regulation of programmed cell death), GO:1901214 (regulation of neuron death), GO:0006796 (phosphate-containing compound metabolic process), GO:0036211 (protein modification process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0060537 (muscle tissue development), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0035051 (cardiocyte differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0042981 (regulation of apoptotic process), GO:0051403 (stress-activated MAPK cascade), GO:0014706 (striated muscle tissue development), GO:0045937 (positive regulation of phosphate metabolic process), GO:0043523 (regulation of neuron apoptotic process), GO:0016310 (phosphorylation), GO:0055007 (cardiac muscle cell differentiation), GO:0006275 (regulation of DNA replication), GO:0051769 (regulation of nitric-oxide synthase biosynthetic process), GO:0043410 (positive regulation of MAPK cascade), GO:0031401 (positive regulation of protein modification process), GO:0032872 (regulation of stress-activated MAPK cascade), GO:0043525 (positive regulation of neuron apoptotic process), GO:0043408 (regulation of MAPK cascade), GO:0043065 (positive regulation of apoptotic process), GO:0048738 (cardiac muscle tissue development), GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process), GO:0031399 (regulation of protein modification process), GO:0071322 (cellular response to carbohydrate stimulus), GO:0045740 (positive regulation of DNA replication), GO:0006468 (protein phosphorylation), GO:0055013 (cardiac muscle cell development), GO:0019220 (regulation of phosphate metabolic process), GO:0051146 (striated muscle cell differentiation), GO:0003298 (physiological muscle hypertrophy), GO:0014897 (striated muscle hypertrophy), GO:0070304 (positive regulation of stress-activated protein kinase signaling cascade), GO:0001932 (regulation of protein phosphorylation), GO:0003300 (cardiac muscle hypertrophy), GO:0042327 (positive regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0032874 (positive regulation of stress-activated MAPK cascade), GO:0042325 (regulation of phosphorylation), GO:0007254 (JNK cascade), GO:0046328 (regulation of JNK cascade), GO:0046330 (positive regulation of JNK cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)