Protein: Cell surface hyaluronidase (Q5FWI3)
Organism: Mus musculus (Mouse)
Function: Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate- size hyaluronan of approximately 5 kDa fragments. Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate. Has an essential function in systemic hyaluronan catabolism and turnover and regulates cell adhesion and migration via hyaluronan degradation at focal adhesion sites. Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity)
Subcellular location: Cell membrane; Single-pass type II membrane protein
InterPro domains:
- IPR019316: G8 domain (domain) [121-245]
- IPR055400: CEMIP, domain X (domain) [993-1174]
- IPR039477: ILEI/PANDER domain (domain) [265-1329]
- IPR055401: CEMIP, beta-helix domain (domain) [515-729]
- IPR052252: Cell surface hyaluronidase CEMIP/CEMIP2 (family) [85-1357]
- IPR039473: Cell surface hyaluronidase, PANDER-like domain (domain) [220-387]
- IPR011050: Pectin lyase fold/virulence factor (homologous_superfamily) [424-735]
Sequence:
MYAAGSRGHSPAFLQPQNGNGHRSPGYVPGKVVPLRPAPPPKNHASAKLTSRSQDAPATFAFSPEEQRTPSESRKRKRHKNTFICFAITSFSFFVALAVILGISSKYAPDENCPDQNPRLRNWDPGQDSAKHIVIKEGDLFRLTSDATVDSIVIQDGGLLVFGDDKDGSKNITLRTRYILIQDGGALHIGAEKCRYRSKATITLYGKSDERESMPIFGKKFIGVEAGGTLELHGAQRTSWTMLARTLHSSGLPFGSYAFEKDFSRGLNVRVIDQDTARVLENEKFDTHEYHNESRRLQEFLRAQEPGRIVAIAVGDSAVKSLLQGTIQMIQDRLGSKLIQGLGYRQAWALVGVIDGGSSSCNESVRNYENHSTGGKALAQGEFYTLDGQKFSVTAYSEWSQGISLSGFRVDIADGVKLHLLDDVSTWEAGDRIVVASTDYSMYQAEELTLLRCPECSRSQVKVKEIPQYLHVGEIIDGIDMRAEVGLLTRNIVIQGEMEDSCYAENHCQFFDYDTFGGHVMIEKNFTSVHLSYVELKHMGQQHMGRYPVHFHLCGDVDSKGGYSQPASVDGLSVHHSFSRCITVHGTSGLLIKDTIGFDTLGHCFFLEDGVEQRNILYHNLGLLTKPGTLLPTDRNSSMCTVMRDGVFGNYVPVPTTDCMAVSTFWIAHPNNHLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLEKPELTPLGIFYNNRVHSNFKAGLFVDKGVKTTNASASDPREYLCLDNSARFRPHQDADPEKPRVAAIIDRLIAFKNNDNGAWVRGGDIIVQNSAFADNGKGLTFASDGSFPSDEGSSQEVTESLFVGESRNYGFQGGQNKYMGTGGIDQKPRTLPRNRTFPIRGFQIYDGPIHLTKSTFKKYVPTPDRYSSAIGFLMKNSWQTTPRNNVSLVKFGPQVSLNVFFGKPGPWFEDCELDGDKNSIFHDIDGSVTGYKDTYVGRMDNYLIRHPNCVNVTKWNAVICSGTYAQVYVQTWNTPNLSMIITRDEYPSHPMVLRGINQRAISPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKDDWIRVGLCYPANTSFQVTVGFLQRQNGSLSRIEDYEPARSMEELQKKPSERKFYFDSGTGLLFLYLRAHSHRDGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYKKPSAVKRMPAMLTGLCQGCGTHQMVFTSDPHKSYLPVRFQSPGKAEIQRGDPSIISVNGTDFTFRSAGALLLIVDACSVPFRVKEKRMFLSADVSHMEEYFKASIPPRSIVLLSTRGEIKQLNISDSLAVLGLAKPAHLYSKGSVVFLGFSGNFAPSWTKLFTSPDEQGLGVLEQFLPLQMEEYGCSRTGSVHRRDLDLLQQALKVL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015929 (hexosaminidase activity), GO:0004415 (hyalurononglucosaminidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0006022 (aminoglycan metabolic process), GO:0006026 (aminoglycan catabolic process), GO:0030203 (glycosaminoglycan metabolic process), GO:0006027 (glycosaminoglycan catabolic process), GO:1903510 (mucopolysaccharide metabolic process), GO:0030212 (hyaluronan metabolic process), GO:0030214 (hyaluronan catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0005794 (Golgi apparatus), GO:0005783 (endoplasmic reticulum), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)