Protein: Heat shock protein 90 beta family member 1 (A0A087WT78)
Organism: Homo sapiens (Human)
Subcellular location: Melanosome
InterPro domains:
- IPR020568: Ribosomal protein uS5 domain 2-type superfamily (homologous_superfamily) [339-594]
- IPR003594: Histidine kinase/HSP90-like ATPase domain (domain) [96-255]
- IPR019805: Heat shock protein Hsp90, conserved site (conserved_site) [94-103]
- IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [66-358]
- IPR037196: HSP90, C-terminal domain (homologous_superfamily) [594-724]
- IPR001404: Heat shock protein Hsp90 family (family) [61-748]
- IPR020575: Heat shock protein Hsp90, N-terminal (domain) [74-279]
Sequence:
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0005102 (signaling receptor binding), GO:0043169 (cation binding), GO:0019899 (enzyme binding), GO:0003723 (RNA binding), GO:0070325 (lipoprotein particle receptor binding), GO:0019902 (phosphatase binding), GO:0046872 (metal ion binding), GO:0050750 (low-density lipoprotein particle receptor binding), GO:0005509 (calcium ion binding), GO:0019903 (protein phosphatase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0051641 (cellular localization), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0006457 (protein folding), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0030029 (actin filament-based process), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0050790 (regulation of catalytic activity), GO:0001666 (response to hypoxia), GO:1901564 (organonitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0060548 (negative regulation of cell death), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0070482 (response to oxygen levels), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:1901700 (response to oxygen-containing compound), GO:0030036 (actin cytoskeleton organization), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0045184 (establishment of protein localization), GO:0034975 (protein folding in endoplasmic reticulum), GO:0046907 (intracellular transport), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0033554 (cellular response to stress), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:1902074 (response to salt), GO:0071417 (cellular response to organonitrogen compound), GO:0046683 (response to organophosphorus), GO:0071705 (nitrogen compound transport), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0071310 (cellular response to organic substance), GO:0051336 (regulation of hydrolase activity), GO:0030163 (protein catabolic process), GO:1902075 (cellular response to salt), GO:1901699 (cellular response to nitrogen compound), GO:0071702 (organic substance transport), GO:1903513 (endoplasmic reticulum to cytosol transport), GO:0022607 (cellular component assembly), GO:0034976 (response to endoplasmic reticulum stress), GO:0009057 (macromolecule catabolic process), GO:0006886 (intracellular protein transport), GO:0010243 (response to organonitrogen compound), GO:0044265 (cellular macromolecule catabolic process), GO:0015031 (protein transport), GO:0036293 (response to decreased oxygen levels), GO:0008104 (protein localization), GO:0014070 (response to organic cyclic compound), GO:0006996 (organelle organization), GO:0033198 (response to ATP), GO:1901701 (cellular response to oxygen-containing compound), GO:0051174 (regulation of phosphorus metabolic process), GO:0097435 (supramolecular fiber organization), GO:0007015 (actin filament organization), GO:0042981 (regulation of apoptotic process), GO:0031399 (regulation of protein modification process), GO:0032527 (protein exit from endoplasmic reticulum), GO:0010921 (regulation of phosphatase activity), GO:0043066 (negative regulation of apoptotic process), GO:0030970 (retrograde protein transport, ER to cytosol), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0071407 (cellular response to organic cyclic compound), GO:0019220 (regulation of phosphate metabolic process), GO:0007010 (cytoskeleton organization), GO:0051017 (actin filament bundle assembly), GO:0061572 (actin filament bundle organization), GO:0014074 (response to purine-containing compound), GO:0036503 (ERAD pathway), GO:0010498 (proteasomal protein catabolic process), GO:0071318 (cellular response to ATP), GO:0043666 (regulation of phosphoprotein phosphatase activity), GO:0030433 (ubiquitin-dependent ERAD pathway), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0035303 (regulation of dephosphorylation), GO:0035304 (regulation of protein dephosphorylation), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)