Protein: Metal transporter (A0A8M3AJ29)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Metal transporter
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR046342: CBS domain superfamily (homologous_superfamily) [384-539]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [560-771]
- IPR045095: Ancient conserved domain protein family (family) [145-786]
- IPR044751: Ion transporter-like, CBS domain (domain) [400-529]
- IPR000644: CBS domain (domain) [473-539]
- IPR002550: CNNM, transmembrane domain (domain) [206-386]
- IPR057492: Metal transporter CNNM1/2/4, immunoglobulin-like domain (domain) [48-204]
Sequence:
MAEPSVPVPPRKMASLSRVRAFTLIFLTASSCLITPTSGKEGGGEETVIIGLRLEDTDDISFMDRGFLRVSERSRVRLRVYGQNINNETWSKIAFTEHERSRVIGNIDSSSGDNQSQEDTSGLHPCGIRTSDILILPNIVLNRKTSGTVEIEVKPLRKTERSKAYYLCIATSTPAVAGAHDPWTENTWIYHDGEDTKVIVVEEKKFLLPFWLQVIFISMLLCLSGMFSGLNLGLMALDPMELQIVQNCGTEKEKNYARKIEPVRSQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGLIAVVMSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMLLTFPASYPVSKLLDYLLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITGDATLDFNSMSEIMESGYTRIPVFEGDRSNIVDLLFVKDLAFVDPDDCTPLKTITKFYSHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTDNKTKKKITHRERKQDFSAFKHMDNEMKVKISPQLLLATLRFLATEVEPFSPSQMSEKILLRLLKHPNVIQEVKYNDKNKKAIEHYLFHRNKPVDYFILVLQGKVEVEAGKEGLRFEAGAFSSYGMMALTASPVPLSLSRTFVVSRAESVAGSPGIENKSPPRSFGLNHSDSLNRSERIEVITPSLGSSNNQLNAFLQIYVPDYSVRAVSDVQYIKVTRQQYQNAVMASRIDKTPQSSESEYTKIEMALTELHDGLTDETTTLFNQTQNCVVHNKSNHTGHSEGPI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015095 (magnesium ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050801 (monoatomic ion homeostasis), GO:0060322 (head development), GO:0098771 (inorganic ion homeostasis), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0010960 (magnesium ion homeostasis), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0055080 (monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016323 (basolateral plasma membrane)