Protein: Ryanodine receptor 1 (A0A8M6YTI2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Multi- pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein
InterPro domains:
- IPR014821: Inositol 1,4,5-trisphosphate/ryanodine receptor (domain) [10-216]
- IPR035761: Ryanodine receptor, SPRY domain 1 (domain) [650-801]
- IPR015925: Ryanodine/Inositol 1,4,5-trisphosphate receptor (family) [17-5108]
- IPR005821: Ion transport domain (domain) [4836-5019]
- IPR013662: RyR/IP3R Homology associated domain (domain) [3906-4021]
- IPR001870: B30.2/SPRY domain (domain) [595-1562]
- IPR013333: Ryanodine receptor (family) [59-1031]
- IPR043136: B30.2/SPRY domain superfamily (homologous_superfamily) [643-1576]
- IPR048581: Ryanodine receptor, junctional solenoid domain (domain) [1654-2154]
- IPR036300: Mir domain superfamily (homologous_superfamily) [107-399]
- IPR003032: Ryanodine receptor Ryr (domain) [858-2970]
- IPR009460: Ryanodine Receptor TM 4-6 (domain) [4433-4741]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [668-1546]
- IPR035910: RyR/IP3 receptor binding core, RIH domain superfamily (homologous_superfamily) [433-2295]
- IPR000699: RIH domain (domain) [451-2397]
- IPR016093: MIR motif (domain) [104-399]
- IPR011992: EF-hand domain pair (homologous_superfamily) [4103-4181]
- IPR035764: Ryanodine receptor, SPRY domain 2 (domain) [1081-1213]
- IPR035762: Ryanodine receptor, SPRY domain 3 (domain) [1419-1558]
- IPR003877: SPRY domain (domain) [666-1561]
Sequence:
MAEGEGGDEEIQFLRTEDQVVLQCTATVLKEQIKLCLSCEGFGNRLCFLETTSNAQNVPPDLAICSFVLEQSLSVRALQEMLANTVDMTEAVDLDKWSSQGGGHRTLLYGHAILLRHYHSSMYLSCLTTSRSLTDKLAFDVGLQLDATGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYASGDLMVDASFMQTLWNMNPVCSGCELAEGYLTGGHVLRLFHGHMDECLAISTPDQGEEERKIAQYEGGAVCSQARSLWRLEPLRIGWSGSHMKWGQAFRVRHITTGRYLCLDDEKGLMVLDPEKANTKQSAFSFRASKEKVEGEKKKRDVEGMGIPEIKYGESMCFMQHISTGLWLTYAALDAKAARLGTMKRRVMLHQEGHMDDALTCSRSQTEESQAARMIYSTTGLFTQFIKGLDSLSGKNKSPGPVSLPLDGVILSLQDLIHYFRPPEEELEHEEKQTKLRSLRNRQNLFQEEGMITIVLECIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFCDNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLRSLCVCNGVAVRSNQNLITENLLPGRDLLLQTNIVNYASSVRPNIFLGTCEGSTQYKKWYFEVMVDYVESFVTAQATHLRVGWAMTEGFSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGHVSRQVASPNQHALAADDVVSCCLDLSVPSISFRINGHPVQGMFENFNLDGLFFPAISFSAGVKARFLLGGRHGDFKFLPPPGYAPCYEALLPKDRMRIEPIKEYKHDFEGVRNLLGPTQSLTHTSFTPCPVDTAQIVLPPHLERIREKLAENIHELWAVTRIEQGWTYGVFRDDNKKLHPCLVDFQSLPEPERNYNLQMSGETLKTLLALGCHVGMGDEKAEENLRKIKLPKTYVMSSGYKPAPLDLNHVKLTPNQNQLVEKLAENGHNVWARDRVRQGWTYSIVQDIVNKRNPRLVPYNLLDERTKKTNRDSVNNAVRTLIGYGYNIEPPDQESSGHGVEDVHGDKVRIFRAEKQYGVTSGKWYFEFEAVTTGEMRVGWARPNVRSDVELGSDELAYVFNGNRAQRWHIGNDPFGRQWQSGDVVGCMIDLIEMNIMFTLNGEMLISDSGSEMAFKDIEIGDGFIPVCTLGLSQVGRINLGQNVSSLRYFAICGLQEGFEPFAINMKRDITMWFSKSLPQFVPVPTDHNHIEVSRVDGTVDSAPCIKITHKTFGSQNANTDMLFFRLSMPVEFHLTFKVPAGTTPLTRALTIPEEEVLEVDPDSDYEVLKKSASRKEQEEKEKEPSVPKDIPGVKENDKDTASEKGKKKGFLFKAKKAAMITPPPPPPLMPRLIEDVVPDDRDDVDIILNTTTYYYSVRIFAGQEPSEVWVGWVTPDFHMYDLNFDLSKVRTVTVTVGDDKGNIHDSIKRSNCYMVWGGEFSSSQQKFSQEDLVIGCLVDLATGLLNFTANGKEINTFYQVEPNTKLFPAVFVLPSSQNMLQLELGKLKNIMPLSAAMFRSERKNPVPQCPPRLDVQMLTPVIWSRMPNHFLNPVVGRVSERHGWMVECTEPLTMMALHIPEENRCIDILELSEQHDLLQFHYHTLMLYCAVCALGNNRVAHALCSHVDESQLFYAIENTYLPGPLRSGYYDLLISIHLESAKRNRLGTNREFIVPMTSETLSITLFPDAEAAHDLPGVGLTTCLRPKLHFSPINFVGTDPDLYTLSPIIPLQNLKTQALSMLTEAVFDGSQAMRDPVGGSVEFHFVPILKLISTLLIMGIFNNEDVKHILKMIDPSVFGKKEEAEEPAEEAAPKEEGEEVKEKEETAEGEEEAVDEGVGEEEEEELKELKKEEGEEGEEVEKAVEEEDGEKVDGEKAEEEKEAEEVGEEAKEEEEEAPEEGLLQMKMPESVKLQMCTLLQYFCDCELRHRVEAIMAYSDNFVGQIQSNQRERYNELMRAFTMSAAETARRTREFRSPPQEQIFLLTNFKHNPEEEDCPVPDEVRETHNNFHNDLLNHCGVHIEEEVEEEEVDTSLRGRLLTLVDKVKSLKQKKEEEEPEPEEEPKPSTLQELISHTMIHWAQEAFIQNPELVRLMFSLLHRQYDALGELIRALPKAYAISAVSVQDTMEMLECLGQIRSLLIVQMGPEEERLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGGDSKEIRFPQMVTNCCRFLCYFCRISRQNQRSMFDHLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEMVVTYLAGCGLRMCPMLLSKGYPDIGWNPGGGERYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGEGGAGLLAAIEEAIKISEDPARDGPTPKKDRRFMFGGEDQHEENRLHLGNAIMSFYSALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLPVQIPTFGKDGQIVEPKMSASFVPDHKASMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRASASLDTVAFSTTEMALALNRYLCSAVLPLLTKCAPLFAGTDHRAIMIDSMLHTIYRLSRGRALTKAQRDVIEDCLMSLVKYLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNGWANFGVTSEEELHLSRKLFWGIFESLAHKKFDAELFKIAMPCICAIAGAIPPDYVDASYSSMTEKKASVDAEGNFDPKPVETTNTIIPERLDAFINKYAEHTHDKWAFEKIQNNWTYGEVLDENAKTHPMLRPYKTFSEKDKEIYRWPIKESIKAMLAWEWTLEKARDGETEVKTEVKATRKISQTAQATYDPSQGYSPQPVDLIGMALSRELQSMAEQLAENYHNTWGRKKKMELQAKGGGTHPLLVPYDTLTAKEKARDREKAQDLLKFLQLNGYAVTRGLKDMEQEISSIEKRFAYGFLQKLLKWMEIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFKNHCLYFLSTPAKVLGSGGHASNKEKEMIASIFCKLAGLVRHRVSLFGTDASAVVNCLHILSRSLDARTVMKSGPEIVKAGLRSFFESAADDIEKMVENLKLGKVSTKNQVKGVSQNISYTTTALLPVLTSLFDHIAQHQFGDDVMLDDLQISCYRIMCSIYSLGTVKTPHAENQRPALGECLAHLAAAMPVAFLEPNLNEFNSYSVYTTKTPRERTILGLPSQVQELCLDIPELDVLMKEIGHLAESGARYTEMPHVIEITLPMLCNYLPRWWERGPENFPEQEGCLCTDVTSEQLNQLLGSIMKIVVNNLGIDEASWMKRLAVFAQPIVSRAKPEMLKSHFIPTMEKLKKRSGKVVAEEEQLRMEGKTEVDSEGGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEDLFRMVGEVFIFWSKSHNFKREEQNFVVMNEINNMSFLTADSKSKMSKAGDGEGGGSDDDRTKKKRRGDRYSVQTSLIVAALKKLLPIGLNMCSPADQELINLAKIRYSLKDTDEEVREFLQNNLHLQGKVEDPSMRWQMALYKETSGKAEDADAPEKVVKRVQEVSAVLYHLELTEHPYKSKKMVWHKLLSKQRRRAVVACFRMTPLYNIPRHRASNMFLDGYKRNWLENEGYSFEDKMIDDLSKALEQEEEEEEETESKPDPLHQLILHFSRTALTEKLKLEVDHLYMSYADIMAKSCHIGEEDEGGEEGGVEPSFEVRQTEMEKEMEKQRLLYQQSRLHDRGAAEMVLQMISACKGETGVMVSSTLKLGISILNGGNSDVQQRMLDYLKDKKDVGFFLSLQALMQTCSVLDLNAFERQNKAEGLGMVSEEGTNMKLQREEKVMADDEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINIIICTVDFLLRLQESISDFYWYYSGKDIIDEPGKRNFSKAMTVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQMHPDQGLRDGDHFWSRTHSEDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFSKAMDSQKQYTPSEIQFLLSCSEADENEMINFEEFANRFQEPAKDIGFNIAVLLTNLSEHVPHDTRLQNFLEQAESVLNYFRPFLGRIEIMGASKRIERIYFEISEANRNQWEMPQVRESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMNIASQISEQEEEVIEDEDEEEEEESGGGGGGEGEGEEGNGEEAPPESSSAFADFIKSIVNFLSLFTFRNLRRRYRKIRKMTIKDMIVGLVMFLYTVLFGILHFIYSVCKGFFLLIWNTLFGGGLVEGAKKMTLTEILTNMPDPTQDEVHGDLPPEPGARKVQEAGGAGEGEEGAGGGEEEAEEGEEDEDGRAGFGPHGGLGDMGETEPEEPPTPEGSPLLKRKLVSEEGVEGEVVVEEEKVEEEPAPEPEKADAENGEKEKEAEPETEDKQEEEQAEIAKAKAKAKKGKKEEEVGFELWNELEIQRIKFMNYLSRNFYNLRFLALFIAFALNFILLFYKVSDRLPGEEEEFEGSAMFEGSGAFEGSAVFEGSAVFEGSGVFEGSGEAEGSGMEENGEEDEENGFVYYFLEESTGYMEPAMAFFSILHTIISFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYVTEQPEDDDIKGQWDRLVLNTPSFPNNYWDKFVKRKVLEKYGDIYGRERIAELLGMDLASLDVSAMTHEKKRQPDPSMFTWLTSIDIKYQIWKFGVVFTDNTFLYLVWYTVMSLLGHFNNFFFACHLLDIAMGVKTLRTILSSVTHNGKQLLMTVGLLAVVVYLYTVVAFNFFRKFYNMSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGSDYFDSTPHGFETHTMEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005262 (calcium channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0099604 (ligand-gated calcium channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0005217 (intracellular ligand-gated monoatomic ion channel activity), GO:0015278 (calcium-release channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0003008 (system process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050879 (multicellular organismal movement), GO:0007610 (behavior), GO:0003012 (muscle system process), GO:0050881 (musculoskeletal movement), GO:0006979 (response to oxidative stress), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0007166 (cell surface receptor signaling pathway), GO:0050877 (nervous system process), GO:0030537 (larval behavior), GO:0007626 (locomotory behavior), GO:0034599 (cellular response to oxidative stress), GO:0050905 (neuromuscular process), GO:0007224 (smoothened signaling pathway), GO:0003009 (skeletal muscle contraction), GO:0062197 (cellular response to chemical stress), GO:0008345 (larval locomotory behavior), GO:0006936 (muscle contraction), GO:0006941 (striated muscle contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0016528 (sarcoplasm), GO:0043227 (membrane-bounded organelle), GO:0016529 (sarcoplasmic reticulum), GO:0043231 (intracellular membrane-bounded organelle)