Protein: non-specific serine/threonine protein kinase (A0A804HJM6)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [295-307]
- IPR001849: Pleckstrin homology domain (domain) [5-110]
- IPR000719: Protein kinase domain (domain) [150-433]
- IPR000961: AGC-kinase, C-terminal (domain) [434-505]
- IPR017892: Protein kinase, C-terminal (domain) [454-499]
- IPR017441: Protein kinase, ATP binding site (binding_site) [156-189]
- IPR039026: Protein Kinase B, pleckstrin homology domain (domain) [4-111]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [145-483]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [1-123]
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTRGVGQRGAGLPSCLWGRSSSSPSLQALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0048519 (negative regulation of biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:1905953 (negative regulation of lipid localization), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0090130 (tissue migration), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0048871 (multicellular organismal-level homeostasis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0001776 (leukocyte homeostasis), GO:0048523 (negative regulation of cellular process), GO:0040012 (regulation of locomotion), GO:0009628 (response to abiotic stimulus), GO:0048869 (cellular developmental process), GO:0051651 (maintenance of location in cell), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0033036 (macromolecule localization), GO:0065009 (regulation of molecular function), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0048870 (cell motility), GO:0008283 (cell population proliferation), GO:0006807 (nitrogen compound metabolic process), GO:0045927 (positive regulation of growth), GO:0050793 (regulation of developmental process), GO:0002683 (negative regulation of immune system process), GO:0009719 (response to endogenous stimulus), GO:0008219 (cell death), GO:0040017 (positive regulation of locomotion), GO:0031294 (lymphocyte costimulation), GO:0040013 (negative regulation of locomotion), GO:0023051 (regulation of signaling), GO:0007165 (signal transduction), GO:0007275 (multicellular organism development), GO:0051051 (negative regulation of transport), GO:0032879 (regulation of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0051235 (maintenance of location), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0048585 (negative regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0090068 (positive regulation of cell cycle process), GO:2000145 (regulation of cell motility), GO:0009314 (response to radiation), GO:0048513 (animal organ development), GO:0002686 (negative regulation of leukocyte migration), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0034764 (positive regulation of transmembrane transport), GO:0009725 (response to hormone), GO:0045184 (establishment of protein localization), GO:0045787 (positive regulation of cell cycle), GO:0010632 (regulation of epithelial cell migration), GO:0010035 (response to inorganic substance), GO:0046907 (intracellular transport), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0042391 (regulation of membrane potential), GO:0010564 (regulation of cell cycle process), GO:0050865 (regulation of cell activation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045597 (positive regulation of cell differentiation), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:1903829 (positive regulation of protein localization), GO:0032891 (negative regulation of organic acid transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0001568 (blood vessel development), GO:1905952 (regulation of lipid localization), GO:0060341 (regulation of cellular localization), GO:0044092 (negative regulation of molecular function), GO:0019538 (protein metabolic process), GO:0001558 (regulation of cell growth), GO:0051649 (establishment of localization in cell), GO:1901700 (response to oxygen-containing compound), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:2000147 (positive regulation of cell motility), GO:0009891 (positive regulation of biosynthetic process), GO:0050867 (positive regulation of cell activation), GO:0071402 (cellular response to lipoprotein particle stimulus), GO:0048872 (homeostasis of number of cells), GO:0001525 (angiogenesis), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0031325 (positive regulation of cellular metabolic process), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009266 (response to temperature stimulus), GO:0002260 (lymphocyte homeostasis), GO:0009968 (negative regulation of signal transduction), GO:0043487 (regulation of RNA stability), GO:0012501 (programmed cell death), GO:0060548 (negative regulation of cell death), GO:0002685 (regulation of leukocyte migration), GO:0030154 (cell differentiation), GO:0034405 (response to fluid shear stress), GO:0048731 (system development), GO:0070848 (response to growth factor), GO:0030155 (regulation of cell adhesion), GO:0071495 (cellular response to endogenous stimulus), GO:0002694 (regulation of leukocyte activation), GO:0051098 (regulation of binding), GO:0006793 (phosphorus metabolic process), GO:0034763 (negative regulation of transmembrane transport), GO:0009408 (response to heat), GO:0035295 (tube development), GO:0009894 (regulation of catabolic process), GO:0051726 (regulation of cell cycle), GO:0007162 (negative regulation of cell adhesion), GO:2001057 (reactive nitrogen species metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0062014 (negative regulation of small molecule metabolic process), GO:0045595 (regulation of cell differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:0051128 (regulation of cellular component organization), GO:0008284 (positive regulation of cell population proliferation), GO:2000146 (negative regulation of cell motility), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0010648 (negative regulation of cell communication), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0045833 (negative regulation of lipid metabolic process), GO:0045913 (positive regulation of carbohydrate metabolic process), GO:0035556 (intracellular signal transduction), GO:0006979 (response to oxidative stress), GO:0032507 (maintenance of protein location in cell), GO:0090132 (epithelium migration), GO:0034762 (regulation of transmembrane transport), GO:0045785 (positive regulation of cell adhesion), GO:0030307 (positive regulation of cell growth), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:0062013 (positive regulation of small molecule metabolic process), GO:0002696 (positive regulation of leukocyte activation), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0032369 (negative regulation of lipid transport), GO:0055094 (response to lipoprotein particle), GO:0090520 (sphingolipid mediated signaling pathway), GO:0045834 (positive regulation of lipid metabolic process), GO:0031295 (T cell costimulation), GO:0045185 (maintenance of protein location), GO:0051341 (regulation of oxidoreductase activity), GO:0071705 (nitrogen compound transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0022409 (positive regulation of cell-cell adhesion), GO:0051246 (regulation of protein metabolic process), GO:0008593 (regulation of Notch signaling pathway), GO:0043488 (regulation of mRNA stability), GO:0001944 (vasculature development), GO:0010675 (regulation of cellular carbohydrate metabolic process), GO:0032881 (regulation of polysaccharide metabolic process), GO:0072595 (maintenance of protein localization in organelle), GO:0071702 (organic substance transport), GO:0043393 (regulation of protein binding), GO:0032368 (regulation of lipid transport), GO:0050678 (regulation of epithelial cell proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0031981 (nuclear lumen), GO:0005634 (nucleus), GO:0015630 (microtubule cytoskeleton)