Protein: procollagen-lysine 5-dioxygenase (A0A8M2B9A3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side
InterPro domains:
- IPR044861: Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain (domain) [599-686]
- IPR050757: Collagen-modifying Glycosyltransferase 25 (family) [12-680]
- IPR001006: Procollagen-lysine 5-dioxygenase, conserved site (conserved_site) [614-621]
- IPR005123: Oxoglutarate/iron-dependent dioxygenase domain (domain) [593-686]
- IPR006620: Prolyl 4-hydroxylase, alpha subunit (domain) [512-685]
- IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [256-560]
- IPR057589: PLOD1-3-like, GT domain (domain) [1-224]
Sequence:
MRTIRQFNYTIQVLGLGEQWRGGDVARTVGGGQKVRWLKTELEKHKDKQNTVIMFVDSYDVILASGPVELLRKFSRFSHRVVFSAEGFCWPDQRLASKYPAVHHGKRYLNSGGFIGFAPEIHAIVQQWKYKDDDDDQLFYTRIYLDKEKRRKFNMTLDHRSQIFQNLNGAIEEVVLKFEKSRVRVRNVAYDTLPVVIHGNGPTKLQLNYLGNYVPTAWTYENGCGICEEDLLDLSHLSDEEMPLVHVAVFIEQPMPFLEEFLERLATLNYPHTRIRLFLHNNVVYHEQHVERFWTRHRSLFTGARIVGPEENLKHDQARTMAVEACKKDVSCDYFFSLDADVALTNPDVLRILIEENKSVIAPMLSRHGKLWSNFWGALSPEGFYSRAEDYIDIVQSKRVGLWNVPYITQVYLIRGETLRSRLAAVSLYQQEGMDPDMSFCKSVREQGIFMFVSNRDEFGRLVSSANYNISRLHPDMWQIFDNPVDWREKYIHENYSRIFEDDESVVEQPCPDVYWFPAFSERMCDDLVETMEEFGQWSGGGHKDERLSGGYENVPTVDIHMNQIQFEKEWLKFLKEYIVPVTEKLYPGYYPKAQAVMNFVVRYRPDEQPSLRPHHDSSTFTINIALNSKGVDYEGGGCRFLRYNCKVESPRKGWSFMHPGRLTHYHEGLPTTRGTRYIMVSFVDP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016491 (oxidoreductase activity), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016043 (cellular component organization), GO:0016477 (cell migration), GO:0006935 (chemotaxis), GO:0022008 (neurogenesis), GO:0048863 (stem cell differentiation), GO:0048864 (stem cell development), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0001667 (ameboidal-type cell migration), GO:0014033 (neural crest cell differentiation), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0007411 (axon guidance), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0014032 (neural crest cell development), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0090497 (mesenchymal cell migration), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis), GO:0001755 (neural crest cell migration), GO:0008045 (motor neuron axon guidance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:1990204 (oxidoreductase complex), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)