Protein: protein-tyrosine-phosphatase (A6IGM6)
Organism: Rattus norvegicus (Rat)
Subcellular location: Membrane; Single- pass type I membrane protein
InterPro domains:
- IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [1678-1973]
- IPR003961: Fibronectin type III (domain) [48-1594]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [34-1457]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [105-1445]
- IPR050713: Receptor-type Tyrosine-protein Phosphatases/Ushers (family) [16-1999]
- IPR000242: Tyrosine-specific protein phosphatase, PTPase domain (domain) [1705-1968]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [1881-1957]
- IPR041201: PTPRJ, transmembrane domain (domain) [1474-1612]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [1905-1915]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [1862-1965]
Sequence:
MLSHGALLALWIALSVLQTGVAEQVKCNFTVLESKVSSLSASIQWRTFGSPCNFSLIYSSDTSGPLWCHPILIDNFTYGCDPKDLQAGTIYNFRIVSLDGEERSLVLQTDPLPPARLEVNPERTTSTTLQVRWTPSSGKVTWYEVQLFDQNNQKIQEVQVQESATWSQYTFLNLTAGSSYKIGITAVSGGKRSFPVYTNGSTGPSPVEDIGISPNPNSLLISWSRGPGNVEQFRLMLMDKGAIVQDTNVDKRDTSYAFRGLTPGHLYNVTIVTMASGLQNSRWKLGRTAPMEVSNLKVTSGGSLTSLNVKWQKPLGVIDSYSITLSHQGTVKESKTLPPRATEIQFKDLVPGRFYQVTIRCVSGELSAEKSAMGRTVPEKVSNLVSYNEIWMKSFAVNWTPPAGDWDHYRILLFNDSLVLLNTTVGKEETHFALEGLELIPGRQYEVEVIVESGNLRNSERCQGRTVPLAVLQLRIKQANETSLGITWRAPLGEWEKYTISLMDRELFVIHKSLSKDAKEYTFTNLMPGRNYKATVTSMSGDLKQSASIQGRTVPAQVTDLEVSNQGMTSSLFTNWTKALGDVEFYQVLLIHENVVVKNESVSSDSSWYSFRALRSGSLYSVVVTTVSGGIPSRQVVAEGRTVPSSVSGVTVNNSGRNDYLSVSWLPAPGEVHHYVVTLSHDSKVVQSLITAKFVSECSFSSLTPGRLYNVTITTKSGNYESHSFSEERTVPDKVQGISVSNSARSDYLKVSWVHATGDFDHYEVTIKNRDSFIQTKSIPKSENECVFARLVPGRLYSITVTTKSGQYEASEQGTGRTIPEPVKNLTLLNRSTEDLHVTWSRANGDVDQYEVQLLFNDMKVFPPIYLVNTATEYQFSALTPGRHYKILVLTISGDVQQPAFIEGLTVPSTVKNIHISANGATDRLTVTWSPGGGDVDSYVVSAFRQDEKVESHTLPKHGSEHTFHRLEAGATYRIAIVSVSGSLRNQIDVLGQTVPASVHGVVADNAYSSNSLTVSWQKALGMAERYDILLLSENGVLLSNTSEPATVKQHKFEDLTPGKKYKMQILTVSGGLFSKEVETEGRTVPAAVTNLRITENSSRHLSFSWTASEGELSWYNIFLYNPDKTLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPAAVNHLKGSNRNMTDSLWFSWSPASGDFDFYELILYNPNGTKKENWREKDVTEWRFQGLIPGRKYTLYVVTHSGDLSNKVTGEGRTAPSPPSLLSFADVANTSLAITWKGPPDWTDYNDFELQWLPGDALTVFNPYSSKKSEGRIVNGLRPGRSYQFSVKTVSGDSWKTYSKPISGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEIEFSRKLEKEKSLLNIMMLVPHRRYLVSIKVQSAGVTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFAVVVREADSMDELRPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAESPDPDRSSKSFNIKLGGEMDSLGGKCDPSQQKFCDGPLKPHTAYRISIRAFTQLFDEGLKEFTKPLYSDTFFSMPITTESEPLFGVIEGVSAGLFLIGMLVALVAFFICRQKASHSRERSSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEDLKDVGRSQSCDIALLPENRGKNRYNNILPYDASRVKLCNVDDDPCSDYINASYIPGNNFRREYIATQGPLPGTKDDFWKMAWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDPLYYGDLILQMVSESVLPEWTIREFKICSEEQLDAHRLLRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFVALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRNEQENPLFPIYENVNPEYHRDAMYSRH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0038023 (signaling receptor activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004721 (phosphoprotein phosphatase activity), GO:0004888 (transmembrane signaling receptor activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0050839 (cell adhesion molecule binding), GO:0045296 (cadherin binding), GO:0004725 (protein tyrosine phosphatase activity), GO:0042578 (phosphoric ester hydrolase activity), GO:0019198 (transmembrane receptor protein phosphatase activity), GO:0016791 (phosphatase activity), GO:0005001 (transmembrane receptor protein tyrosine phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0030154 (cell differentiation), GO:0016477 (cell migration), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0008347 (glial cell migration), GO:0007399 (nervous system development), GO:0042063 (gliogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0045211 (postsynaptic membrane), GO:0005794 (Golgi apparatus), GO:0043197 (dendritic spine), GO:0098590 (plasma membrane region), GO:0005783 (endoplasmic reticulum), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0005791 (rough endoplasmic reticulum), GO:0044309 (neuron spine)