Protein: Double-strand break repair protein MRE11 (Q9W6K1)
Organism: Xenopus laevis (African clawed frog)
Function: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing
Subcellular location: Nucleus
InterPro domains:
- IPR003701: DNA double-strand break repair protein Mre11 (family) [3-691]
- IPR029052: Metallo-dependent phosphatase-like (homologous_superfamily) [9-372]
- IPR004843: Calcineurin-like, phosphoesterase domain (domain) [14-250]
- IPR007281: Mre11, DNA-binding (domain) [295-464]
- IPR041796: DNA double-strand break repair protein Mre11, N-terminal metallophosphatase domain (domain) [15-276]
- IPR038487: Mre11, capping domain (homologous_superfamily) [307-412]
Sequence:
MSSSSSSLDDEDTFKILVATDIHLGFMEKDAVRGNDSFVAFDEILRLAQDNEVDFLLLGGDLFHDNKPSRRTLHICLEQLRKYCMGDRPIEFEVLSDQSVNFGYSKFPWVNYQDNNLNISLPVFSVHGNHDDPTGADALCALDILSSAGLVNHFGRATSVEKIDISPVLLQKGHSKIALYGLGSIPDERLYRMFVNKQVMMLRPREDESSWFNLFVIHQNRSKHGPTNYIPEQFLDEFLDLVIWGHEHECKIAPTRNEQQLFYVSQPGSSVATSLSPGEAEKKHVGLLRIKGKKMNMQKIPLQTVRQFFIEDLVLSDYPDIFNPDNPRVTQEIETFCIEKVEAMLDTAERERLGNPRQPDKPLIRLRVDYTGGFEPFNTLRFSQKFVDRTANPKDIIHFFRHKEQKDKKDSITINFGKIDSKPLLEGTTLRVEDLVKEYFKTAEKNVQLSLLTERGMGEAVQEFVDKEEKDALEELVKFQLEKTQRFLKERHIDAEEEKIDEEVRKFRETRKTNTNEEDEEVREAIQRARTHRSQAPDVEMSDEDDDALLRKVSLSDDEDVRASMPARGRGRGRARGGRGQSTTTRGTSRRGRGSASADQPSSGRATKATGKNMSILDAFKPSSRQPTARNVAKKTYSEDIEDDDSDLEEVSFTPSSVIESRRTSSTSTSYSRKSTQPQSQATKAHFFDDDDDEEDFDPFKKSGPSRRGRR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:1903047 (mitotic cell cycle process), GO:0035556 (intracellular signal transduction), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0010948 (negative regulation of cell cycle process), GO:0043170 (macromolecule metabolic process), GO:0051726 (regulation of cell cycle), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0033554 (cellular response to stress), GO:0016043 (cellular component organization), GO:0045786 (negative regulation of cell cycle), GO:0044260 (cellular macromolecule metabolic process), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0007346 (regulation of mitotic cell cycle), GO:0000075 (cell cycle checkpoint signaling), GO:0006974 (cellular response to DNA damage stimulus), GO:0007093 (mitotic cell cycle checkpoint signaling), GO:0090304 (nucleic acid metabolic process), GO:1901987 (regulation of cell cycle phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:1901988 (negative regulation of cell cycle phase transition), GO:1902750 (negative regulation of cell cycle G2/M phase transition), GO:0031570 (DNA integrity checkpoint signaling), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:0000723 (telomere maintenance), GO:0044818 (mitotic G2/M transition checkpoint), GO:0051276 (chromosome organization), GO:0044774 (mitotic DNA integrity checkpoint signaling), GO:1902749 (regulation of cell cycle G2/M phase transition), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0000077 (DNA damage checkpoint signaling), GO:0000076 (DNA replication checkpoint signaling), GO:0044773 (mitotic DNA damage checkpoint signaling), GO:0010389 (regulation of G2/M transition of mitotic cell cycle), GO:0007095 (mitotic G2 DNA damage checkpoint signaling), GO:0010972 (negative regulation of G2/M transition of mitotic cell cycle), GO:0032200 (telomere organization), GO:0033314 (mitotic DNA replication checkpoint signaling), GO:0031573 (mitotic intra-S DNA damage checkpoint signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)