Protein: Protein Wnt (A6IB96)
Organism: Rattus norvegicus (Rat)
Function: Ligand for members of the frizzled family of seven transmembrane receptors
Subcellular location: Secreted, extracellular space, extracellular matrix
InterPro domains:
- IPR005817: Wnt (family) [36-349]
- IPR018161: Wnt protein, conserved site (conserved_site) [200-209]
- IPR013300: Wnt-7 protein (family) [17-324]
- IPR043158: Wnt, C-terminal domain (homologous_superfamily) [289-349]
Sequence:
MTRKARRCLGHLFLSLGIVYLRIGDFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0001664 (G protein-coupled receptor binding), GO:0005109 (frizzled binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0007267 (cell-cell signaling), GO:0023056 (positive regulation of signaling), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0042127 (regulation of cell population proliferation), GO:0198738 (cell-cell signaling by wnt), GO:0010646 (regulation of cell communication), GO:0009611 (response to wounding), GO:0080134 (regulation of response to stress), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0007166 (cell surface receptor signaling pathway), GO:0010647 (positive regulation of cell communication), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0008284 (positive regulation of cell population proliferation), GO:0042060 (wound healing), GO:0032355 (response to estradiol), GO:0033993 (response to lipid), GO:0016055 (Wnt signaling pathway), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:1902533 (positive regulation of intracellular signal transduction), GO:0014070 (response to organic cyclic compound), GO:1902531 (regulation of intracellular signal transduction), GO:0060070 (canonical Wnt signaling pathway), GO:0043408 (regulation of MAPK cascade), GO:0043410 (positive regulation of MAPK cascade), GO:0032872 (regulation of stress-activated MAPK cascade), GO:0070304 (positive regulation of stress-activated protein kinase signaling cascade), GO:0046328 (regulation of JNK cascade), GO:0032874 (positive regulation of stress-activated MAPK cascade), GO:0046330 (positive regulation of JNK cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0098685 (Schaffer collateral - CA1 synapse), GO:0098978 (glutamatergic synapse)