lokahq/bioreason-rl huggingface dataset:
Protein: E3 ubiquitin-protein ligase CBL (A0A8M2B4G4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome
InterPro domains:
- IPR024159: Adaptor protein Cbl, PTB domain (domain) [31-335]
- IPR011992: EF-hand domain pair (homologous_superfamily) [163-247]
- IPR015940: Ubiquitin-associated domain (domain) [862-901]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [380-389]
- IPR014742: Adaptor protein Cbl, SH2-like domain (domain) [240-336]
- IPR009060: UBA-like superfamily (homologous_superfamily) [861-899]
- IPR003153: Adaptor protein Cbl, N-terminal helical (domain) [35-159]
- IPR014741: Adaptor protein Cbl, EF hand-like (domain) [163-246]
- IPR018957: Zinc finger, C3HC4 RING-type (domain) [365-403]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [335-419]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [248-334]
- IPR036537: Adaptor protein Cbl, N-terminal domain superfamily (homologous_superfamily) [31-161]
- IPR024162: Adaptor protein Cbl (family) [4-543]
- IPR001841: Zinc finger, RING-type (domain) [365-404]
Sequence:
MAGNLKKGGGLIGMMKDAFQPHHHLHHSHHQPGAVDKKTVEKCWKFMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGDNEYFRVFMENLTKKTKQTISLFKDGKERMFEENSQPRRNLTKLSLIFSHMLAELKAIFPNGLFQGDNFRITKADAAEFWRRSFGDKTIVPWKVFRQALHEFHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRTQNPDLTGLCEPSPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESEGQGCPFCRCEIKGTEPIVVDPFDPKDPNSAASYGCRGMFGAEGAPSPSYDDDDDDRLEETPFMISKLVGSKVERPPSPMSISPQPVVPPVPPRLDLLPLRPTNPPGASSPGATSKAPSHHKDKPLPLPPALRDLPPPPPPDRPHPAGADNRLPRRPLPSTPGDPSRDKLPPAPPNRNMPDWNSRPVPKAPSQPPASGDTRGSRELSNRHSLPLQLPSTLDSRTEAPRNNGPPSLDHQLSFGSSNPASDYDSPKVKPSASANAIYSLAIRPVAAARTQTGEETNENDEESEYMTPSSRPVLPSAAGEAVPRPPPPLSLSPSMLNELESESPQMYEAMYNIQAQALTASAPQARDSDYSELPPLTCSNGPRDPVGAYAEEEEEEENSYDYPKPHLSAALARRTLSDANSPSSSAFSRLSFDSDLGAAATVLDPSEAPERPPKPLPRRINSDRRPSPVPPGASPGPSQQISSEIEHLLSQGYSHQDIQKALMIAQNNIEMAKNILREFVSIPSTAHILT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis), GO:0060216 (definitive hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Si:dkey-191g15.12 isoform X1 (A0A8M2BEZ8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR050119: C-C chemokine receptor type 1-9-like (family) [49-372]
- IPR001416: Atypical chemokine receptor 3 (family) [52-376]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [77-361]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [92-353]
Sequence:
MRTKPWINIAHSTSIKGKMTEIQSSSPNEKLGLSASELTEFFAMWEELNFTDSNNNSSRVEAQMCPASFNRSALLNAMCTLYAFIFVVGLAANALVVWVNMRSQRHYHETHMYILNLAVADLCVVATLPVWVSSLAQGGHWAFGQAACKLTHLLFSVNLFASIFFLTCMSVDRYLSVVRFREISHRRGRQVRRLVCAITWLLALFASVPDTYFLRSVKSQYSHVTLCLPVYPEDNPLQWMVGIQLSFVVLGFAIPFPIIAVSYALLANTLASTSTHSPSNGDQDRSVSKKVILMYIVVFIACWAPYHAVLLADALAMLGVLPLGCSSENGLFVALHLTQCLSLLHCCVNPVVYSFAHRHYRYDLMKAFIFKYSTRTGLARLIDGSQGIETEYAMVENNPPTVT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019955 (cytokine binding), GO:0019956 (chemokine binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0016477 (cell migration), GO:0006935 (chemotaxis), GO:0009888 (tissue development), GO:0048731 (system development), GO:0048882 (lateral line development), GO:0048880 (sensory system development), GO:0048883 (neuromast primordium migration), GO:0048925 (lateral line system development), GO:0048916 (posterior lateral line development), GO:0048920 (posterior lateral line neuromast primordium migration), GO:0048881 (mechanosensory lateral line system development), GO:0048915 (posterior lateral line system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0009986 (cell surface), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Nuclear pore complex protein Nup153 isoform X5 (A0A8M3ASW6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR001876: Zinc finger, RanBP2-type (domain) [634-849]
- IPR013913: Nucleoporin Nup153, N-terminal (domain) [98-604]
- IPR036443: Zinc finger, RanBP2-type superfamily (homologous_superfamily) [635-848]
- IPR026054: Nuclear pore complex protein (family) [4-814]
Sequence:
MAATGGGKIRSRRHHIASKPYAKGKQQPGLITRVTDTVKSIVPSWLQKYFRNGEGPEGGASAAGVEHNNMTPPPNGSDEAPLRDGRDSPEPSTSNTEPSTSRASLNFQEALSRPPLNRTHLQFPSLDGSPALGGSSSLFSQPSTSTAPFSGSPFAVTSNFSLVKEIKDSSSQHEDDNISTTSGFSSRASDKDVPTSKTVPLLWSPETERTHSGSQTAHSGLKKPAFNLSVFGTSSSSVLNSSVLNSSQLGDSPFYPGKTTYGGASAMRTARSRPATPYQPPVRRQIKAKPTGAQPCGVTSATARRILQSLERMSSPLADAKRIPSTVSSPLSASLNHTDLDISNYQAKRKRLEPSVPPVQKLVVPAAAAVSGNRSISFRPSLTPGGVSRGVEKTSRETPVRQSPPISEPAQAPPPSTSTLSYPLSSTPAANSAALGGGKMKRERAIRPSSKRPDDEVAEEPDLPPASLPSNFTLPTFTFSTPPPTSSLKSSTAPLITVSEEPAANKQPAAPSTPPSAPFTFSSPIVKATAASPPSFSPSSGFTFSAPTMKMGPSFSNGKIVPSVAPVKSVVIEEKEFEGPFKPAKVLKQGSVLDILKGPGFASPSQNSTDKPLQSTSTTTSSPFSGFGDKFRPPAGSWNCGTCMLQNKPSDKKCVACLAPQPNTDSSKSDSKPAEAPASISSLFAPPAGSWECDTCLVSNKPDAVKCVACDTAKPGTGVKSSLTLLAASESSSSTTTTATTTAAALTSTGLLGLGDKFKKPEGAWDCDVCMVQNKAQDLKCVACLTAKPGAAAAPLSTPASAPVSSAAPLLGFGDKFKKPEGSWECDVCCVQNKADDQQCVACQSAKPGAKIESKGFSSSFGVQSNSTDSNTSGFKFGTGSTDSSSSSAGLKFGGTFSDSSTTGGIKFGFGLSSTSSEGFKFGGSSSDAGGAKLSSTLSESTATKESSTKSFAFGGSADDTLEKKSKTQESNTGFKFGGGSGMASGSENSSFLFGAKPSEKGSSNPSFSFPVPQSKVEKDAPSETPPVSNTTTTTTAANALPVFGKSLVAESSAPKFGEPATKEQTLVTSTFTFGKPEEKKDTSAPSSTFLFGSSKEAEKPTPNLGFAFSEPDPPKDFPKPALTFGKPAESTEPPKPSFGFGQSLTAPAPSANPSPFVFSSAAPSSGFGSGQTPIFGQSASQPSAPAFGSAAPSFSASATPASTFGAKPSSAPVFGQQANAAPTFGSTAASTGQGGFQFGSTGGFGASATSNSVFNFGGGSAAPAASPAMPALNPPAGGGFGFSPTPAFNIGSAKSSFTASPAGQNSIAGRKIKTAVRRRK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0031490 (chromatin DNA binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)
Protein: Serine/threonine-protein kinase Chk2 isoform X1 (A0A8M2BC68)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [313-325]
- IPR000719: Protein kinase domain (domain) [193-456]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [42-194]
- IPR000253: Forkhead-associated (FHA) domain (domain) [90-164]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [186-466]
Sequence:
MSEEAGPSGESQSQTQSQTQSQPASSSSSAPTSSSQGSSSGSGTLSSVDTVPVQELQSIPEDEEEVQPQVWGRIIPLKQGFSVLNCTENQYSFGRDKRCDYSFSNSILKKSPYFNTYSKKHFRIFRDENLVYLEDLSGNGTWVDDEKLGNGKQSLLSNNSVIALAEQKHQVFMFIDKMADDQANLPLEFSKKYHIARKIGTGVCGEVKLAIEKETFKKVALKTINKHDFPSIGTATRNAEREIEILKKIDHPCLIKTEDFYQTEDSYYIVLEYIEGGELFGRIKAKKKLEEDIAKLYFYQMLKAVEYLHNNGIIHRDLKPENVLLASHDDICLIKITDFNQSKILEESSLMKTLCGTPTYVAPEVFTHASTVGYTKAVDYWSLGVLLFICLGGYPPFNTECTTMSVREQIINGEYRFIPSQWKNVSNEAKDLVKKLLVVDPQKRLSVEEALEHPWLKDDRMRQNANQLMNPGAANQPMRPEATRQKRKAQEGEGEPASKRKPGP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0033554 (cellular response to stress), GO:0006974 (cellular response to DNA damage stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Glucosidase 2 subunit beta (A0A8M2BBI5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR009011: Mannose-6-phosphate receptor binding domain superfamily (homologous_superfamily) [448-556]
- IPR044865: MRH domain (domain) [457-558]
- IPR002048: EF-hand domain (domain) [257-292]
- IPR028146: Glucosidase II beta subunit, N-terminal (domain) [54-215]
- IPR039794: Glucosidase II beta subunit-like (family) [50-557]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [270-282]
- IPR036607: Glucosidase 2 subunit beta-like (domain) [420-558]
Sequence:
MPTRHLKDGVNVYQTAGKKCKFFKLFRSRASSGTQCLFLHLGIMTCVHLLLTLVFAVSLGTPVEVHRPRGVPLSKKPFYEENKPFTCLDGSKTILFDQVNDDYCDCKDGSDEPGTAACPNGKFHCTNAGYKPTFIPSSRINDGICDCCDTTDEYNSGAKCENTCKELGRKEREVLQKMAEITKEGFLLKQQLIEEAKKGRGEKQSKVTEMQDNKKQLEEKVEALRTVKETAEQPEREAKERHLKAWEEQKAAIRLVKDKAKMAEAFLELDDNADGLVSVSELQSHAELDSDTDGTLSEAEAKGLMGGVEQVDTATFESVWENIKDKYHSESQPEEPAPVETPVDEVKEPVVDNESEPYPEDISEEEDEDDDDDDEYHEEDEKAPPTMKTPEKSQEDEEAMPPYEADTQVLIEAAQKARDDFEEAEKALREMDDQIRNIEKELSFDFGPNAEFTYLYSQCYELSTSEYIYRLCPFNRVSQKPKFGGSETNLGTWGSWSGPENNKYLSMKYEHGTGCWQGPNRSTTVKLTCGKETMLTSTSEPSRCEYLMEFITPAVCQEPSNIDLSAHGHTEL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0043169 (cation binding), GO:0003723 (RNA binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0072001 (renal system development), GO:0001822 (kidney development), GO:0061008 (hepaticobiliary system development), GO:0048793 (pronephros development), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Calymmin isoform X5 (A0A8M6Z999)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
Sequence:
MLRWTILRMMLLLWMTRVTLQGGTGYQPQKSNGNAAPISPGGYGSNNNAANLKGYGVYGGAQNKPANRGHLPHGYGNGNTNGNNGYKAPSYGGYSNLLGTHPRKGAGLGFGAGPAATKGQGSNPGGSSQYMGNTNGGTKGPKPGYGGYPNGGAAVQPGTGSSQYKGFPSGGIKGPNPGFAANAGASNEKGVKPNGYGGYPNGGAANQPNGGSSHYMGYPNGGTKGPKPGYGANAGPSAGQVAKPNGYGGYPNAGATNQPNGGPFQNMGYPNGGTKGPKPGYGAKAGPSAGHVAKPNGNGGYPNGGATSQHNGGSSQFMGYPNGGTKGPKSGYGANAGPSAGQVAKPNGNGRYPIGGVANQPNRGSSQNMGYPNGRTKGPKQGYGGYPNGGAANQPNGGSTQNMGYSNGGTKGPKQGYGANAGPSAGQVAKPNGYGGYPNGGATNQPNGGSSQYMGYPNGGAKGPKAGYGAKSGPSSGQVSKPNGSSQYMGYPNGGTNGLKPGYGAKARTTYGQGAKPQNGFGGYSNGGAINQPNTGSSQYIGYPNGGFKGPLNGQGGRPYNGYGVPGYTSKGPKAANSGYMPVITGNKGASIGKGPKGEILSAEAPSQAPLSNTKGVLPVAQQEPVTGLLPNQGTKGLPVLQQTKGQILQASLPQSKTQNSMVPQFASNPFMQGPSSYKPSKMYKPPTSTIPIEKPEIPVIPQSVPAPESAFIPQTSQTTPLEQEQVLSLEQKSQVTAQPVTQQGSISSQAAQSTPVLQQAEIQSNPALPQLKNPTTTNPELTGLEQPNGQVQGAVPAKPDCGPEGRPNGQWVKLTNPGFGYPNGKGEGLSQPGFGAGIGGYPTQGMNNGHKAGYGGYGNQLKNHAGLQGGPPARLGTKGKSQTKYGIGGLPFGGSPSGYQSNPYGQYGNDGQRYGAKPYNPKAPGKYGYGSLPYNSQAFPESVARSPDFGGFPYNGQPLGYGSGKSTGKYGQKGPQYGGQSLGHGPDAISGKYGSPESLYTPETVNLGGNAKSTKYGNPAVSYELLGPVTDGQSVEENRSIETLHQGPEIDGQKAVDNFGDGEIPPHPDVPGAGEANAQSTEKYGTEDYNAGKPQPEAVSFPAVPTVGPAVTSLDTTLSLDGSSPVPVSVPDAVHEVPVSPILPQPDLPTLMLQPAPPQQIQIQQHLKLHFQPHSNSQTGKEGKYKLSGFFGNKYQG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005201 (extracellular matrix structural constituent)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009790 (embryo development), GO:0048731 (system development), GO:0001501 (skeletal system development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix)
Protein: BTB/POZ domain-containing protein 9 (A0A8M9Q9R1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR052407: BTB/POZ domain-containing protein 9 (family) [1-599]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [14-165]
- IPR008979: Galactose-binding-like domain superfamily (homologous_superfamily) [291-548]
- IPR034091: BTBD9, BACK-like domain (domain) [137-236]
- IPR000210: BTB/POZ domain (domain) [33-137]
- IPR011705: BTB/Kelch-associated (domain) [143-241]
- IPR000421: Coagulation factor 5/8, C-terminal domain (domain) [293-551]
Sequence:
MSDSHPLRPMNSASEIDHLHLLSEQLGALVPGEEYSDVTFVVEEKRFPAHRVILAARCQYFRALLYGGLRESRAQAEVRLEETRAEAFSMLLRYLYTGRATLSEAREETLLDFLGLAHRYGLQPLEVSICEFLRTLLSTRNVCLVFDVASLYCLNGLAEACMAYMDRNAVEVLKSDGFLTLSKSALLTVVRRDSFASSEREIFQALCHWCHHNGDGPEAKEVMSAVRLPLMTLFEMLNVVRPSGLLSPDDLLDAIQTRSESRDMDLNYRGMLIPEENIATMKHGAVVVKGELKSALLDGDTQNYDLDHGFSRHPIEEEGRAAGIQVRLGQPSIVNHIRLLLWDKDSRSYSYYVEVSMDELDWVRVVDHSKFLCRSWQQLYFPARVCRFIRVVGTHNTVNKVFHLVALECMYTLRPFTLEKGLLVPTENVATVQACASVVEGVSRSRNALLNGDTSHYDWDSGYTCHQLGSGAIVIQLAQPYMLCSMRLLLWDCDERSYSYYVELSTNQQNWVKIVDRTKDECRSWQTLTFDRQPASFIRIVGTHNTANEVFHCVHFECPAQMDTVVKEGSPGPDQPKPETSSQNSYSQSLMAQKPSSSSSHA
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Phospholipid scramblase (A0A8M3AZ51)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane
InterPro domains:
- IPR005552: Scramblase (family) [21-261]
- IPR025659: Tubby-like, C-terminal (homologous_superfamily) [78-257]
Sequence:
METNNGYPVELQPNKNAIHPAPGYGQGAAIPGHGQVVMMPVPQRPDGCPPGLEYLTQIDQLLVQQKVELAEVILGWETNNKYIVKNSMGQQVFYVAEENDCCNRQFCGPLRSFVIHVQDNLGQEVMRLMRPLKCGSCFCPCCLQELEIQSPPGYPIGYVIQNWHPFLPKFTIQNEKKEAVLKIEGPFCSCRCCSDVNFDVLSLDESTKVGKISKQWTGLVREAFTDADNFGISFPMDLDVKIKAVLFGACFLIDFMFFEHNK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0030030 (cell projection organization), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: NHS-like protein 1 isoform X2 (A0A8M2B7N1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR024845: Actin remodeling regulator NHS-like (family) [82-1552]
Sequence:
MGNTPPSQLQSPSGLDPAQTPGVRSDCGIRRRLLASKVHQRPESLWTPKPMLRAEVKGSQGDTLTRSQSCCKRNSLSCFPTVSNLDEEKKWTVHYTAPWHQQENVFLPGSRPACVEDLHRQAKVNLKTALRECDKLRKDGFRSSQYYSQGPTFSGSSSSQHEDEDLEGDDADKKSTASSGEEEKDSCQMRAQSPAQVEGVEVDGQMSSSKASVLPTPEEKMRQQAQAVLTDIVPINVTGETFDRQASIRRSLINTDTLVRRPKKVKRRKTISGVPDSVQQELAAKGRGGELRPQSMFIPGQYSTLGRVMNGNSTLRQSVTKDSGCQTEAVKIVPPSVRRIRAQKGQGIAAQMAGISTSATNISSVSDGSSTGGSIVAMAPQFGNDIQRFHSLPRGARVSLNAEPIYSSTPFRKEDSCAKAPKQIGKLQVDNTAVHMRNAPRVCTQARPKSQEVRGSQREWGSVSGPACVVSPHAAYSTSLIPNATLSCSAEVFALHSKSSPGQSPLSGSPYTKARPLSMVSVVNSGSTSSVGTGSHTPDAGMKDTCSETGQSDSSLHSHSTIAAGTLSSDEQWIYDTPDNALPRRTMTSSCSTPINHLYSSLERSSKGTDSSSLYSMDNDGYYTSMHLDSGLRSRSHGSGHGHGIGGRAVRHSMYECLGEQEDRNSLCSDHSLSRSISLRKPKKPPLPPARTDSLRRKPGKNSSPSANIGQSNIRNGSLLNESLIATLQQSLQNGLKGKGSSTSPSHSPCSDYEDPWMLRPRSQSSISASSSGVSATGMAHVYSICPVTPSHSDTSSLRSDYADSWGYYMEYPRPSGDQTQSPCTNSHSAGQVSEMANGRGPLNGNQANLPAVQEGSDMSAKPRTGTSSPDRVHRLTSPSSGYSSQSNTPTAGTPVPSFMRCMSPSGKPKPRVPERKSSLLSSVSISSSSTSLSSNTSDSNRSNIPPPPPLPAAPVVLVPLNPPSFPPPLPPPSPVCTEDQKFPPPPPPLPTTPHQQASMNPLQNNSSPEFPPPPPPEVLTDPACSGFNSSFSPPPPPPPPPLPTYSPSQNQHLPHMTPQTPSSASLKEIKGCLKPVNLEGRPVLPQSEEPNKVSMPLITPFALQSVQLRPAKRPENNEVSRTDRPQTPEKTHPTVPQISCISPNVSLSSTEEKPSIQHSQDGLVEAQTDYSVKSNSDPTSFLTNGPIDLGEATDEVDGLKTFLSTQVEKSLNSTPKKKPPMISKKPKFSLTFSSVDHVRDFVSAEVLDPIPVLEKEEETTEKSSFDISVPPVEIRDISPTNGESQEFSQSSGTTILDVDKSTSEAEDEEERDDEDVTSSTGSFSSKDDENGDVFESSTLDVAQSPSINGDSCGDMVTPTRPRTTEDLFAAIHRSKRKVLGRKESEEDRSRGPLSPPVTPTAQSPSLTSSLPRQSGSIQRSLRKSATSSDTFKALLLKKGSRSESSFRMSATEMLRSTDPRFQRTRSLDSSFDPASPTSESPCSSPGRSKRVADDWARNDGMFSTSPSLIGPKYGRSRTPPSAASSKYNARCRILSSPMTVICERDGELTDCEDPVSPSNTPLPISQDSNSTLCEQSSS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0046983 (protein dimerization activity), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0030154 (cell differentiation), GO:0016477 (cell migration), GO:0048731 (system development), GO:0001764 (neuron migration), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Mitochondrial Rho GTPase (A0A8M9PZT5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mitochondrial GTPase involved in mitochondrial trafficking
Subcellular location: Membrane; Single- pass type IV membrane protein. Mitochondrion outer membrane; Single-pass type IV membrane protein
InterPro domains:
- IPR001806: Small GTPase (family) [1-439]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [163-295]
- IPR011992: EF-hand domain pair (homologous_superfamily) [148-334]
- IPR020860: MIRO domain (domain) [2-546]
- IPR013567: EF hand associated, type-2 (domain) [185-270]
- IPR021181: Mitochondrial Rho GTPase (family) [1-625]
- IPR002048: EF-hand domain (domain) [154-305]
- IPR052266: Mitochondrial Rho GTPase/EF-hand domain-containing protein (family) [148-407]
- IPR013566: Mitochondrial Rho GTPase 1/3, EF hand associated, type-1 (domain) [307-379]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [3-552]
Sequence:
MRKDVRILLVGEPKVGKTSLIMSLVSEEFPAVVPYRAEEITIPADVTPERVPTHIVDYSEAEQTDEQLFQEISKANVICIVYSVNNQKSIEKVTSHWIPLINERTDKDSRVPLILVGNKSDLVEHSSMETVLPIMNKYTEIETCVEMRTACVLALTRIFKVSDSDNDGVLNDNELTFFQKTCFNTPLAPQALEDVKNVVRKNISDGVHDNGLTLKGFLFLHTLFIQRGRHETTWAVLRRFGYDDDLELHQDYLFPPLKIPPDSTTELNHDAYLFLQSVFDKHDKDRDGSLSPGELIDLFDVFPYVPWGLDVNSTVCTNDQGWITYQGYLSQWTLTTYLDVQRCLEYLGYLGYSIIAEQESQASAITVTRDKKLDLQKKQTQRNVFRCHVFGITGSGKTGFLQGFLGRNLVHQRAIREEHKSYYAISTAHVYGQEKYLLLHKVFPDFDFLSEMELTCDVACLIYDVSNPCSFEYCAQIFKQYFMDSKTPCMLIAAKSDLPETKQQYGMTPLEFCRKHKMPPPQSYTCNTAGAPSKDIFIKLATMAVYPHARLRCMCTCNRCTFCLCQNFLNSELVQTVRTKLYTVILSRHIIHAELKNSSLWLKASVGATICAVLGFAIYRTLLRNR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0007005 (mitochondrion organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)