Protein: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (Q94511)
Organism: Drosophila melanogaster (Fruit fly)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By similarity)
Subcellular location: Mitochondrion inner membrane. Note=Matrix and cytoplasmic side of the mitochondrial inner membrane
InterPro domains:
- IPR054351: NADH-ubiquinone oxidoreductase, ferredoxin-like domain (domain) [180-246]
- IPR000283: NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site (conserved_site) [71-199]
- IPR019574: NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding (domain) [118-163]
- IPR006963: Molybdopterin oxidoreductase, 4Fe-4S domain (domain) [259-315]
- IPR050123: Prokaryotic molybdopterin-containing oxidoreductase (family) [108-722]
- IPR036010: 2Fe-2S ferredoxin-like superfamily (homologous_superfamily) [42-114]
- IPR001041: 2Fe-2S ferredoxin-type iron-sulfur binding domain (domain) [40-118]
- IPR010228: NADH:ubiquinone oxidoreductase, subunit G (family) [44-632]
- IPR015405: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial-like (domain) [677-712]
- IPR006656: Molybdopterin oxidoreductase (domain) [315-635]
Sequence:
MIRAPLVKALGALGSPTHQMASRAVRTSAMVAQTPAKAPEKIEVFVDDIPVQVVPGTTVLQAAAQIGVEIPRFCYHERLAVAGNCRMCLVEVEKSPKPVAACAMPVMKGWRIKTNSDLTRKAREGVMEFLLMNHPLDCPICDQGGECDLQDQAMAFGSDRSRFTDINYTGKRAVEDKDIGPLVKTIMTRCIHCTRCVRFASEIAGVDDLGTTGRGNDMQIGTYVEKLFLTELSGNVIDLCPVGALTNKPYSFVARPWEIRKVSSIDVLDAVGSNIVVSTRTNEVLRILPRENEDVNEEWLADKSRFACDGLKRQRLVAPMVRMPNGELQAVEWEGALIAVAKAIKAAGGQIAGISGQLADLEAQVALKDLLNRLGSEVVATEQGFIAGGTDNRANYLLNSTIAGLEEADAVLLVGTNPRYEAPLVNTRLRKAYVHNELQIASIGPKIDLSYDHENLGADAALVKDVCSGAHAFSKVLEGAKKPAIIIGADLLERADGAAIHATVAEYCKKLKKPNWNPFNVLQTNAAQVGALDVGYKAGAQTAVKAQPKVLFLLNADAGKVTREQLPKDCFVVYIGSHGDNGASIADAVLPGAAYTEKQGIYVNTEGRPQQTLPGVSPPGMAREDWKILRALSEVVGKPLPYDNLDELRNRLEDVAPHLTRLGQLEPAGDAGAAGTISKSIGGGAIDIKLKELRDYFMTDAISRASPTMAKCISAVNKQQRENEAKQSVAI
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0022804 (active transmembrane transporter activity), GO:0008137 (NADH dehydrogenase (ubiquinone) activity), GO:0015399 (primary active transmembrane transporter activity), GO:0003954 (NADH dehydrogenase activity), GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor), GO:0050136 (NADH dehydrogenase (quinone) activity), GO:0015453 (oxidoreduction-driven active transmembrane transporter activity), GO:0003955 (NAD(P)H dehydrogenase (quinone) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0022900 (electron transport chain), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0045333 (cellular respiration), GO:0022904 (respiratory electron transport chain), GO:0019646 (aerobic electron transport chain), GO:0009060 (aerobic respiration), GO:0042773 (ATP synthesis coupled electron transport), GO:0042775 (mitochondrial ATP synthesis coupled electron transport), GO:0006119 (oxidative phosphorylation), GO:0006122 (mitochondrial electron transport, ubiquinol to cytochrome c)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)