Protein: Voltage-dependent L-type calcium channel subunit alpha (A0A8M9QAY0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death
Subcellular location: Cell membrane, sarcolemma, T-tubule. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Membrane; Multi- pass membrane protein. Perikaryon. Postsynaptic density membrane
InterPro domains:
Sequence:
MLRGLFSWRRLKHERLEEEVEVRFKGKLVSERELGYTHVRPGGSNYSSPSLAPVPSLNEDEHVGGGGGVLGLAPEHIPTPGAPLSWQAAIDAARQAKLMGTTGAPISTASSTQRKRQHYTKPKKQASTASTRPPRALLCLTLKNPIRRACINIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLCHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGGTSMGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHRTCFFYKDGHKGHIAEEKPAPCAPSSAHGRHCSPPNITQCMMGWEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGNSWPWLYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENDDEGLDDDKPRNLSMPASENESVNTDNAPAGDMEGETCCTRMANRISKSKFSRYSRRWNRLCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHHQQPEWLTNVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKRQNSEKPPLEDEKKEEKIELKSITSDGETPTATKINIDEYTGEDNEEKNPYPVNDFPGEDDEEEPEMPVGPRPRPLSDIQLKEKAVPMPQAKAFFIFSPSNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTSLLQFMFACIGVQLFKGKFFYCTDTSKQTQAECRGAYILYKDGNVGKPEKAQRSWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQSQSFNKAMNILNMLFTGLFTVEMILKLIAFKPRHYFVDAWNTFDALIVVGSVVDIAITEVNGLQNTEDNARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDNSQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACSPNRPCEKGSEINHSSEDCGSHFAIFYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVAKIPPKTALSLQAGLRTLHDMGPEIRRAISGDLTVEEELERAMKETVCAASEDDIFRVKRSGGLFGNHVNYYHQSDGHVSFPQSFTTQRPLHISKSGSPGEAESPSHQKLVDSTFTPSSYSSSGSNANINNANNTAIGHRYPKPTVSTVDGQTGPPLTTIPLPRPTWCFPNKRSCFYDTFMRSDSSDSRLPIIRREEASTDETYDETFLDERDQAMLSMDMLEFQDEESKQLAPMVEAEVGEERRPWQSPRRRAFLCPTALGRRSSFHLECLRKHNRPDVSQKTALPLHLVHHQALAVAGLSPLLRRSHSPTLFTRLCSTPPASPSGRSGGGPCYQPVPSLRLEGSGSYEKLNSSMPSVNCSSWYSDSNGNHSGRAQRPVSLTVPPVTRRDSISLAHGSAGSLVEAVLISEGLGRYAHDPSFIQVAKQEIAEACDMTMEEMENAADNILNANAPPNANGNLLPFIQCRDTGSQESRCSLSLGLSPATGSDGALEAELEESEGAGQRNSPLMEDEDMECVTSL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005262 (calcium channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005245 (voltage-gated calcium channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0051641 (cellular localization), GO:0055085 (transmembrane transport), GO:0051234 (establishment of localization), GO:0051239 (regulation of multicellular organismal process), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0048878 (chemical homeostasis), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0019725 (cellular homeostasis), GO:0065009 (regulation of molecular function), GO:0140352 (export from cell), GO:0007154 (cell communication), GO:0040008 (regulation of growth), GO:0007610 (behavior), GO:0050801 (monoatomic ion homeostasis), GO:0086065 (cell communication involved in cardiac conduction), GO:0050790 (regulation of catalytic activity), GO:0048638 (regulation of developmental growth), GO:0044093 (positive regulation of molecular function), GO:0009314 (response to radiation), GO:0098660 (inorganic ion transmembrane transport), GO:0007588 (excretion), GO:0044057 (regulation of system process), GO:0033500 (carbohydrate homeostasis), GO:0003014 (renal system process), GO:0051649 (establishment of localization in cell), GO:0046620 (regulation of organ growth), GO:0008217 (regulation of blood pressure), GO:0098771 (inorganic ion homeostasis), GO:0030534 (adult behavior), GO:0034220 (monoatomic ion transmembrane transport), GO:0010817 (regulation of hormone levels), GO:0003013 (circulatory system process), GO:0045184 (establishment of protein localization), GO:0055082 (intracellular chemical homeostasis), GO:0099536 (synaptic signaling), GO:0098739 (import across plasma membrane), GO:0007611 (learning or memory), GO:0006810 (transport), GO:0007632 (visual behavior), GO:0070727 (cellular macromolecule localization), GO:0032940 (secretion by cell), GO:0050877 (nervous system process), GO:0023061 (signal release), GO:0098655 (monoatomic cation transmembrane transport), GO:0035592 (establishment of protein localization to extracellular region), GO:0003018 (vascular process in circulatory system), GO:0009416 (response to light stimulus), GO:0050890 (cognition), GO:0071705 (nitrogen compound transport), GO:0009306 (protein secretion), GO:0008015 (blood circulation), GO:0090659 (walking behavior), GO:0051336 (regulation of hydrolase activity), GO:0009914 (hormone transport), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0007612 (learning), GO:0060073 (micturition), GO:0099587 (inorganic ion import across plasma membrane), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0046879 (hormone secretion), GO:0006811 (monoatomic ion transport), GO:1903522 (regulation of blood circulation), GO:0055074 (calcium ion homeostasis), GO:0035150 (regulation of tube size), GO:0008542 (visual learning), GO:0098657 (import into cell), GO:0098662 (inorganic cation transmembrane transport), GO:0055080 (monoatomic cation homeostasis), GO:0008344 (adult locomotory behavior), GO:0051339 (regulation of lyase activity), GO:0015031 (protein transport), GO:0042593 (glucose homeostasis), GO:0099537 (trans-synaptic signaling), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0043085 (positive regulation of catalytic activity), GO:0007628 (adult walking behavior), GO:0045761 (regulation of adenylate cyclase activity), GO:0006812 (monoatomic cation transport), GO:0019229 (regulation of vasoconstriction), GO:0031281 (positive regulation of cyclase activity), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0070588 (calcium ion transmembrane transport), GO:0008016 (regulation of heart contraction), GO:0042886 (amide transport), GO:0098916 (anterograde trans-synaptic signaling), GO:0015833 (peptide transport), GO:0002790 (peptide secretion), GO:0071692 (protein localization to extracellular region), GO:0006939 (smooth muscle contraction), GO:0030073 (insulin secretion), GO:0006816 (calcium ion transport), GO:0006874 (intracellular calcium ion homeostasis), GO:0051349 (positive regulation of lyase activity), GO:0045055 (regulated exocytosis), GO:0030072 (peptide hormone secretion), GO:0007268 (chemical synaptic transmission), GO:0017156 (calcium-ion regulated exocytosis), GO:0030001 (metal ion transport), GO:0045762 (positive regulation of adenylate cyclase activity), GO:0097553 (calcium ion transmembrane import into cytosol)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0005891 (voltage-gated calcium channel complex), GO:0034702 (ion channel complex), GO:0034703 (cation channel complex), GO:0034704 (calcium channel complex)