Protein: Fibroblast growth factor receptor 2 (A6IA29)
Organism: Rattus norvegicus (Rat)
Subcellular location: Golgi apparatus. Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR050122: Receptor Tyrosine Kinase (family) [29-326]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [185-197]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [44-320]
- IPR000719: Protein kinase domain (domain) [44-333]
- IPR017441: Protein kinase, ATP binding site (binding_site) [50-80]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [44-320]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [34-320]
Sequence:
MNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLTQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYDPCLPQYPHINGSVKT
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0060089 (molecular transducer activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0038023 (signaling receptor activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004888 (transmembrane signaling receptor activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0019838 (growth factor binding), GO:0016301 (kinase activity), GO:0019199 (transmembrane receptor protein kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004713 (protein tyrosine kinase activity), GO:0017134 (fibroblast growth factor binding), GO:0004714 (transmembrane receptor protein tyrosine kinase activity), GO:0005007 (fibroblast growth factor receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0040007 (growth), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048589 (developmental growth), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035265 (organ growth), GO:0042221 (response to chemical), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0048729 (tissue morphogenesis), GO:0043207 (response to external biotic stimulus), GO:0009611 (response to wounding), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0008285 (negative regulation of cell population proliferation), GO:0048513 (animal organ development), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0098868 (bone growth), GO:0001704 (formation of primary germ layer), GO:0048598 (embryonic morphogenesis), GO:0042127 (regulation of cell population proliferation), GO:0009888 (tissue development), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:0009790 (embryo development), GO:0007166 (cell surface receptor signaling pathway), GO:0008284 (positive regulation of cell population proliferation), GO:0003416 (endochondral bone growth), GO:0048333 (mesodermal cell differentiation), GO:0071559 (response to transforming growth factor beta), GO:0097305 (response to alcohol), GO:0032496 (response to lipopolysaccharide), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0071310 (cellular response to organic substance), GO:0001707 (mesoderm formation), GO:0007369 (gastrulation), GO:0048661 (positive regulation of smooth muscle cell proliferation), GO:0071774 (response to fibroblast growth factor), GO:0002237 (response to molecule of bacterial origin), GO:0060485 (mesenchyme development), GO:0050678 (regulation of epithelial cell proliferation), GO:0048660 (regulation of smooth muscle cell proliferation), GO:0042060 (wound healing), GO:0060348 (bone development), GO:0050680 (negative regulation of epithelial cell proliferation), GO:0001501 (skeletal system development), GO:0033993 (response to lipid), GO:0048332 (mesoderm morphogenesis), GO:0007498 (mesoderm development), GO:0048762 (mesenchymal cell differentiation), GO:1901701 (cellular response to oxygen-containing compound), GO:0071363 (cellular response to growth factor stimulus), GO:0032526 (response to retinoic acid), GO:0071560 (cellular response to transforming growth factor beta stimulus), GO:0001837 (epithelial to mesenchymal transition), GO:0045471 (response to ethanol), GO:0071300 (cellular response to retinoic acid), GO:0071396 (cellular response to lipid), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0044344 (cellular response to fibroblast growth factor stimulus), GO:0008543 (fibroblast growth factor receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0009986 (cell surface), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)