Protein: DNA-binding protein RFX7 (F8VPJ6)
Organism: Mus musculus (Mouse)
Function: Transcription factor. Acts as a transcriptional activator by binding to promoter regions of target genes, such as Rec8, Mxd4 and Ddit4. Plays a role in natural killer (NK) cell maintenance and immunity. May play a role in the process of ciliogenesis in the neural tube and neural tube closure (By similarity)
Subcellular location: Nucleus
InterPro domains:
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [109-182]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [108-183]
- IPR003150: DNA-binding RFX-type winged-helix domain (domain) [106-183]
- IPR039779: RFX-like DNA-binding protein (family) [12-1109]
Sequence:
MAEEQQQPPPQQLDAPQQLPLSAPNPGVALPALVPGLPGTEANALQHKIKNSICKTVQSKVDCILQEVEKFTDLEKLYLYLQLPSGLSSAEKSDQNAMSSSRAQQMHAFSWIRNTLEEHPETSLPKQEVYDEYKSYCDNLGYHPLSAADFGKIMKNVFPNMKARRLGTRGKSKYCYSGLRKKAFVHMPTLPNLDFHKTGDGLEGVEPSGQLQNIDEEVISSACRLVCEWAQKVLSQPFDTVLELAHFLVKSHYIGTKSMAALTVMAAAPAGLKGIPQPSAFIPTAESNSFQPQVKTLPSPIDAKQQLQRKIQKKQQEQKLQSPLPGESSAKKPEGTTANGVANLPNGNPAILSPQPIGIVVAAVPSPIPVQRTRQLVTSPSPMNSPDGKVLPLNVQVVTQHMQSVKQTPKTPQNVPASPGGDRSARHRYPQILPKPANTSALTIRSPTTVLFTSSPIKTAVVPASHMSSLNVVKMTTISLTPSNSNAPLKHSASVSSATGTTEESRIVPQIKNGSVVSLQSPGSRASSTGGTSAVEVKMEPEGSSDEHPLQCQENSEETKAPLTTSSALWGQKSNTDGTVPKPSNEGVTEVKTTKVCDQRTKCKNRCNEILSGISAGNNQSTVTLSVATQNLPFTSTSSPSNGDSVNKDPKICTKSPRKRLSATLQESQVPPVKKPIVEQLSAVTIEGQKPGTVKKDQKVPHSGKTESSTAGAQIPNKVSISVSSQIIEDQPVNPALVTSEPVLEQQTTPSSSPDVKVKLEGSVFLLDRESKSDGSFNRNEWQQVTKDSDFIAASCEHQQDISVMTIAEHPDIHDLEKSVWELEGMPQDTYSQQLHSQIPESSLNEIQAQSSDQLPLQSELKEFESSVSQTNESYFPFDDELTQDSIVEELVLMEQQMSMNNSHSYGNCLGMSLQNQSVTPGAPMSSHASSTHFYHPIHSNGTPIHTPTPTPTPTPTPTPTPTPTSEMIAGSQSLSRESPCSRLAQTTPVDSALGSSRHTPIGTPHSNCSSSVPPSPVECRNPFAFTPISSSMAYHDASIVSSSPVKPMQRPMATHPDKTKLEWMNNGYGGVGNSSVSGHGILPSYQELVEDRFRKPHAFAVPGQSYQSQSRHHDTHFGRLTPVSPVQHQGATVNTNKQEGFAVPAPLDNKGTNSSAGSNFRCRSVSPAVHRQRNLSGSTLYPVSNIPRSNVTPFGSPVTPEVHVFTNVHTDACANNIAQRSQSVPLTVMMQTAFPNALQKQTNSKKITNVLLSKLDSDNDDSVRGLGINNVPSNYTARMNLTQILETSPVFPSANSQNMIDSSTSVYEFQTPSYLTKSNSTDQISFSPGDNQAQSEIGEQQLDFNSTVKDLLSGDNLQTSQQLVGQVASDLTNTASDFSSDIRLSSDLSGSINDLNTLDPNLLFDPGRQQGQDDEATLEELKNDPLFQQICSESMNSMTSSGFEWIESKDHPTVEMLG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)