Protein: Paired box 2 (A0A7P0TAC9)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus
InterPro domains:
- IPR043565: PAX family (family) [6-364]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [12-134]
- IPR022130: Paired-box protein 2 C-terminal (domain) [279-387]
- IPR001523: Paired domain (domain) [10-136]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [5-142]
- IPR043182: Paired DNA-binding domain (domain) [44-60]
Sequence:
MEERAGPAAGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLSSPYYYSAAPRGSAPAAAAAAYDRH
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0003676 (nucleic acid binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0003008 (system process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0001763 (morphogenesis of a branching structure), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0048729 (tissue morphogenesis), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0072028 (nephron morphogenesis), GO:0016043 (cellular component organization), GO:0072006 (nephron development), GO:0090066 (regulation of anatomical structure size), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0035239 (tube morphogenesis), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:0061138 (morphogenesis of a branching epithelium), GO:0031324 (negative regulation of cellular metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0009888 (tissue development), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0050877 (nervous system process), GO:0080090 (regulation of primary metabolic process), GO:0060562 (epithelial tube morphogenesis), GO:0072009 (nephron epithelium development), GO:0030030 (cell projection organization), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043069 (negative regulation of programmed cell death), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:2000378 (negative regulation of reactive oxygen species metabolic process), GO:0032990 (cell part morphogenesis), GO:0072088 (nephron epithelium morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0050678 (regulation of epithelial cell proliferation), GO:0060993 (kidney morphogenesis), GO:0010468 (regulation of gene expression), GO:0048666 (neuron development), GO:0048754 (branching morphogenesis of an epithelial tube), GO:0000904 (cell morphogenesis involved in differentiation), GO:0061326 (renal tubule development), GO:0007399 (nervous system development), GO:0072164 (mesonephric tubule development), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0048858 (cell projection morphogenesis), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0072001 (renal system development), GO:0043086 (negative regulation of catalytic activity), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:0051336 (regulation of hydrolase activity), GO:0051248 (negative regulation of protein metabolic process), GO:0007600 (sensory perception), GO:0050679 (positive regulation of epithelial cell proliferation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0022008 (neurogenesis), GO:0051254 (positive regulation of RNA metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0060429 (epithelium development), GO:0051253 (negative regulation of RNA metabolic process), GO:0001822 (kidney development), GO:0030182 (neuron differentiation), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0072080 (nephron tubule development), GO:0050953 (sensory perception of light stimulus), GO:0042981 (regulation of apoptotic process), GO:0051346 (negative regulation of hydrolase activity), GO:0030162 (regulation of proteolysis), GO:0001823 (mesonephros development), GO:0052547 (regulation of peptidase activity), GO:2001141 (regulation of RNA biosynthetic process), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0001656 (metanephros development), GO:0061333 (renal tubule morphogenesis), GO:0003338 (metanephros morphogenesis), GO:0001658 (branching involved in ureteric bud morphogenesis), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0001657 (ureteric bud development), GO:0048699 (generation of neurons), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0072171 (mesonephric tubule morphogenesis), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0043066 (negative regulation of apoptotic process), GO:0072073 (kidney epithelium development), GO:0120036 (plasma membrane bounded cell projection organization), GO:0006355 (regulation of DNA-templated transcription), GO:0031175 (neuron projection development), GO:0045861 (negative regulation of proteolysis), GO:0072078 (nephron tubule morphogenesis), GO:0048812 (neuron projection morphogenesis), GO:0052548 (regulation of endopeptidase activity), GO:0010466 (negative regulation of peptidase activity), GO:0061564 (axon development), GO:0045892 (negative regulation of DNA-templated transcription), GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:0060675 (ureteric bud morphogenesis), GO:0072207 (metanephric epithelium development), GO:0072163 (mesonephric epithelium development), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0007409 (axonogenesis), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0007601 (visual perception), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:2000116 (regulation of cysteine-type endopeptidase activity), GO:0010951 (negative regulation of endopeptidase activity), GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:2000117 (negative regulation of cysteine-type endopeptidase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)