Protein: Adenosine deaminase RNA specific (A0A7P0Z4F9)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [2-70]
- IPR044456: ADAR1, first double-stranded RNA binding domain (domain) [207-277]
- IPR044457: ADAR1, third double-stranded RNA binding domain (domain) [411-481]
- IPR042371: Z-binding domain (domain) [1-64]
- IPR002466: Adenosine deaminase/editase (domain) [525-908]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [1-71]
- IPR014720: Double-stranded RNA-binding domain (domain) [208-480]
Sequence:
MAEIKEKICDYLFNVSDSSALNLAKNIGLTKARDINAVLIDMERQGDVYRQGTTPPIWHLTDKKRERMQIKRNTNSVPETAPAAIPETKRNAEFLTCNIPTSNASNNMVTTEKVENGQEPVIKLENRQEARPEPARLKPPVHYNGPSKAGYVDFENGQWATDDIPDDLNSIRAAPGEFRAIMEMPSFYSHGLPRCSPYKKLTECQLKNPISGLLEYAQFASQTCEFNMIEQSGPPHEPRFKFQVVINGREFPPAEAGSKKVAKQDAAMKAMTILLEEAKAKDSGKSEESSHYSTEKESEKTAESQTPTPSATSFFSGKSPVTTLLECMHKLGNSCEFRLLSKEGPAHEPKFQYCVAVGAQTFPSVSAPSKKVAKQMAAEEAMKALHGEATNSMASDNQVRKIGELVRYLNTNPVGGLLEYARSHGFAAEFKLVDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQGKQEAADAALRVLIGENEKAERMGFTEVTPVTGASLRRTMLLLSRSPEAQPKTLPLTGSTFHDQIAMLSHRCFNTLTNSFQPSLLGRKILAAIIMKKDSEDMGVVVSLGTGNRCVKGDSLSLKGETVNDCHAEIISRRGFIRFLYSELMKYNSQTAKDSIFEPAKGGEKLQIKKTVSFHLYISTAPCGDGALFDKSCSDRAMESTESRHYPVFENPKQGKLRTKVENGEGTIPVESSDIVPTWDGIRLGERLRTMSCSDKILRWNVLGLQGALLTHFLQPIYLKSVTLGYLFSQGHLTRAICCRVTRDGSAFEDGLRHPFIVNHPKVGRVSIYDSKRQSGKTKETSVNWCLADGYDLEILDGTRGTVDGPRNELSRVSKKNIFLLFKKLCSFRYRRDLLRLSYGEAKKAARDYETAKNYFKKGLKDMGYGNWISKPQEEKNFYLCPV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0003723 (RNA binding), GO:0019239 (deaminase activity), GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines), GO:0004000 (adenosine deaminase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0042221 (response to chemical), GO:0048524 (positive regulation of viral process), GO:0019222 (regulation of metabolic process), GO:0006955 (immune response), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0050792 (regulation of viral process), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0045070 (positive regulation of viral genome replication), GO:0045069 (regulation of viral genome replication), GO:0043207 (response to external biotic stimulus), GO:0044085 (cellular component biogenesis), GO:0046483 (heterocycle metabolic process), GO:0044092 (negative regulation of molecular function), GO:0006952 (defense response), GO:0051649 (establishment of localization in cell), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0045087 (innate immune response), GO:0045184 (establishment of protein localization), GO:0098542 (defense response to other organism), GO:1901360 (organic cyclic compound metabolic process), GO:1903900 (regulation of viral life cycle), GO:0046907 (intracellular transport), GO:0006139 (nucleobase-containing compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0006810 (transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0009615 (response to virus), GO:0043086 (negative regulation of catalytic activity), GO:0034097 (response to cytokine), GO:0071705 (nitrogen compound transport), GO:0051246 (regulation of protein metabolic process), GO:0072594 (establishment of protein localization to organelle), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0051248 (negative regulation of protein metabolic process), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0006886 (intracellular protein transport), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0015031 (protein transport), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0008104 (protein localization), GO:0043933 (protein-containing complex organization), GO:0051338 (regulation of transferase activity), GO:0010467 (gene expression), GO:0010629 (negative regulation of gene expression), GO:0051174 (regulation of phosphorus metabolic process), GO:0006606 (protein import into nucleus), GO:0006913 (nucleocytoplasmic transport), GO:0033365 (protein localization to organelle), GO:0016070 (RNA metabolic process), GO:0006611 (protein export from nucleus), GO:0031399 (regulation of protein modification process), GO:0065003 (protein-containing complex assembly), GO:0031400 (negative regulation of protein modification process), GO:0031047 (RNA-mediated gene silencing), GO:0006396 (RNA processing), GO:0019220 (regulation of phosphate metabolic process), GO:0009451 (RNA modification), GO:0043549 (regulation of kinase activity), GO:0022618 (ribonucleoprotein complex assembly), GO:0051348 (negative regulation of transferase activity), GO:0035455 (response to interferon-alpha), GO:0045936 (negative regulation of phosphate metabolic process), GO:0071826 (ribonucleoprotein complex subunit organization), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0034504 (protein localization to nucleus), GO:0051170 (import into nucleus), GO:0001932 (regulation of protein phosphorylation), GO:0034470 (ncRNA processing), GO:0070918 (regulatory ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0033673 (negative regulation of kinase activity), GO:0042326 (negative regulation of phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0070922 (RISC complex assembly), GO:0016553 (base conversion or substitution editing), GO:0051168 (nuclear export), GO:0035196 (miRNA processing), GO:0006469 (negative regulation of protein kinase activity), GO:0031054 (pre-miRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)