Protein: Ribonucleoside-diphosphate reductase (M0R486)
Organism: Rattus norvegicus (Rat)
Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
InterPro domains:
- IPR008926: Ribonucleotide reductase R1 subunit, N-terminal (homologous_superfamily) [6-214]
- IPR013509: Ribonucleotide reductase large subunit, N-terminal (domain) [142-212]
- IPR005144: ATP-cone domain (domain) [1-92]
- IPR013346: Ribonucleotide reductase, class I, alpha subunit, C-terminal (domain) [145-742]
- IPR039718: Ribonucleoside-diphosphate reductase large subunit (family) [1-791]
- IPR000788: Ribonucleotide reductase large subunit, C-terminal (domain) [216-738]
Sequence:
MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGRHSPMVASSTLEIVMAHKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKLLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPEDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKALKEEEEKERNTAAMVCSLENREECLMCGS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0042802 (identical protein binding), GO:0000166 (nucleotide binding), GO:0016725 (oxidoreductase activity, acting on CH or CH2 groups), GO:1901265 (nucleoside phosphate binding), GO:0016728 (oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor), GO:0061731 (ribonucleoside-diphosphate reductase activity), GO:0004748 (ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0008283 (cell population proliferation), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0044238 (primary metabolic process), GO:0061351 (neural precursor cell proliferation), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0060322 (head development), GO:0009314 (response to radiation), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0030900 (forebrain development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0007548 (sex differentiation), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0046661 (male sex differentiation), GO:0060041 (retina development in camera-type eye), GO:0000278 (mitotic cell cycle), GO:0007420 (brain development), GO:0061458 (reproductive system development), GO:0009112 (nucleobase metabolic process), GO:0007399 (nervous system development), GO:0048880 (sensory system development), GO:0021846 (cell proliferation in forebrain), GO:0007423 (sensory organ development), GO:0008406 (gonad development), GO:0046546 (development of primary male sexual characteristics), GO:0007417 (central nervous system development), GO:0072527 (pyrimidine-containing compound metabolic process), GO:0010212 (response to ionizing radiation), GO:0008584 (male gonad development), GO:0001654 (eye development), GO:0006206 (pyrimidine nucleobase metabolic process), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043025 (neuronal cell body), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)