Protein: Gamma-tubulin complex component (A0A804HJH7)
Organism: Homo sapiens (Human)
Function: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
InterPro domains:
- IPR007259: Gamma-tubulin complex component protein (family) [105-889]
- IPR040457: Gamma tubulin complex component, C-terminal (domain) [509-888]
- IPR013087: Zinc finger C2H2-type (domain) [649-673]
- IPR041470: Gamma tubulin complex component protein, N-terminal (domain) [218-506]
- IPR042241: Gamma-tubulin complex component, C-terminal domain superfamily (homologous_superfamily) [509-887]
Sequence:
MSEFRIHHDVNELLSLLRVHGGDGAEVYIDLLQKNRTPYVTTTVSAHSAKVKIAEFSRTPEDFLKKYDELKSKNTRNLDPLVYLLSKLTEDKETLQYLQQNAKERAELAAAAVGSSTTSINVPAAASKISMQELEELRKQLGSVATGSTLQQSLELKRKMLRDKQNKKNSGQHLPIFPAWVYERPALIGDFLIGAGISTDTALPIGTLPLASQESAVVEDLLYVLVGVDGRYVSAQPLAGRQSRTFLVDPNLDLSIRELVHRILPVAASYSAVTRFIEEKSSFEYGQVNHALAAAMRTLVKEHLILVSQLEQLHRQGLLSLQKLWFYIQPAMRTMDILASLATSVDKGECLGGSTLSLLHDRSFSYTGDSQAQELCLYLTKAASAPYFEVLEKWIYRGIIHDPYSEFMVEEHELRKERIQEDYNDKYWDQRYTIVQQQIPSFLQKMADKILSTGKYLNVVRECGHDVTCPVAKEIIYTLKERAYVEQIEKAFNYASKVLLDFLMEEKELVAHLRSIKRYFLMDQGDFFVHFMDLAEEELRKPVEDITPPRLEALLELALRMSTANTDPFKDDLKVRVGCSGTCQIFTQVWQKRELCHAVATSSHRGPKAALPGLQCPRDSRAVRGPRCGLWSTDAVSTTPPVTEAHLRCRHVSCRKALTRYQMLFRHMFYCKHVERQLCSVWISNKTAKQHSLHSAQWFAGAFTLRQRMLNFVQNIQYYMMFEVMEPTWHILEKNLKSASNIDDVLGHHTGFLDTCLKDCMLTNPELLKVFSKLMSVCVMFTNCMQKFTQSMKLDGELGGQTLEHSTVLGLPAGAEERARKELARKHLAEHADTVQLVSGFEATINKFDKNFSAHLLDLLARLSIYSTSDCEHGMASVISRLDFNGFYTERLERLSAERSQKATPQVPVLRGPPAPAPRVAVTAQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0044085 (cellular component biogenesis), GO:0060322 (head development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0016477 (cell migration), GO:0031109 (microtubule polymerization or depolymerization), GO:0007420 (brain development), GO:0007020 (microtubule nucleation), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0001764 (neuron migration), GO:0007417 (central nervous system development), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0022607 (cellular component assembly), GO:0007010 (cytoskeleton organization), GO:0048699 (generation of neurons), GO:0065003 (protein-containing complex assembly), GO:0046785 (microtubule polymerization), GO:0051258 (protein polymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0099080 (supramolecular complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005881 (cytoplasmic microtubule), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0070013 (intracellular organelle lumen), GO:0099513 (polymeric cytoskeletal fiber), GO:0005634 (nucleus), GO:0005856 (cytoskeleton), GO:0031981 (nuclear lumen), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)