lokahq/bioreason-rl huggingface dataset:
Protein: mitogen-activated protein kinase kinase (A0A8M3B0Q3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [219-231]
- IPR017441: Protein kinase, ATP binding site (binding_site) [102-125]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [92-384]
- IPR000719: Protein kinase domain (domain) [96-361]
Sequence:
MATSSPSSNPASASNNPTQLHPAQSQHITTMSSMQGKRKALKLNFANPPIKTTSRITSGLPFQNPHIERLRTHSIESSGKLKISAEQHCDFTAEDLKDLGEIGRGAYGSVNKMAHKPSGQIMAVKRIRSTVDEREQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSSLDEVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRKGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSSSEERQFSPKFINFVNLCLTKDESKRPKYKELLKHAFIQMYEERSVDVATYVCRILDQMPPSPSSPMYVD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:0003002 (regionalization), GO:0009799 (specification of symmetry), GO:0009855 (determination of bilateral symmetry), GO:0009953 (dorsal/ventral pattern formation), GO:0048263 (determination of dorsal identity), GO:0048262 (determination of dorsal/ventral asymmetry)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: ubiquitinyl hydrolase 1 (A0A8M3B3I3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR018200: Ubiquitin specific protease, conserved site (conserved_site) [169-609]
- IPR001394: Peptidase C19, ubiquitin carboxyl-terminal hydrolase (domain) [168-655]
- IPR028889: Ubiquitin specific protease UPS, catalytic domain (domain) [168-658]
- IPR009060: UBA-like superfamily (homologous_superfamily) [4-72]
- IPR003903: Ubiquitin interacting motif (conserved_site) [30-142]
- IPR054109: UBA-like domain (domain) [15-59]
- IPR054108: Ubiquitin carboxyl-terminal hydrolase 25/28, UIM (conserved_site) [81-131]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [163-655]
- IPR050164: Ubiquitin carboxyl-terminal hydrolases (family) [111-658]
Sequence:
MTVEQNVLQQHSQKHQQTLLNQLREVTGTTDVQLLQQALQVSNGDLVEAVAFLTEKNAKVPQQDEATYYQTAQITNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLEESNRAFRETGITDEEQAISRVLEASIAENKASLKRTHTEVWSDSPNPHERKRMENCPVGLKNVGNTCWFSAVIQSLFNLLEFQRLVLHYSPPARMQDLPRNQKEHRNLPFMQELRHLFSLLVGSKRKYVDPSGAVEILKDAFKSSESQQDVSEFTHKLLDWLEDAFQIKAEEDREGEKPKNPMVELFYGRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSAENSAKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPSMLYMDRYMDRNREITRIKREEIRRLKEHLTVLQQRLERYLSYGSGPKRFPLADVLQYAMEFASSKPVCTSPVEDIDTTAPPGGTIAQLPPPASAGEQPDACVSAEGSGSGLQASQQQQQRVSIHKPFTQSRVPPDLPMHPAPRHITEEELRVLESCLHRWRSEVENDTRDLQASISRIHRTIELMYSDKSMMQVPYRLHAVLVHEGQANAGHYWAYIYDRHHQRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYIDDKKPFLIQEEFDKETGQMLSGLDKLPPDLKVFVEADNKLFEREMEEWDALQARKLQQEKLALAAAAAAAAAASVAVQPMSTEPCSPDNTAPSAAPQHDPEYMEQQSPSGDSKHLQEDTERAISKAAAEHDEKSPEALLNTSQSSHPDSKLTSDPCPPPDPEQDDPTCPPPGPQRVVEVAIPNVGTFVIQSKEGGYDDEAMMTPNMQGIIMAIGKSRSVYDKCGPEAAFFKAMKVEYTRLLRLAQEDTPPERDYRLQHVIVFFIHNEAPKKIVERTLLMQFADRNLGFDERCKSIMKVARAKLELIKPDEVNLEEYEMWHQDYRIFRETSVFLLIGLELFMKKSFVEALMYLIYAYQYNKELLAKGPYRGHDEELIAHYRRECLLKLNEYAAALFETGEEAKVNTGLSIMNDLVVPCLPLLLVDEMEEKDMVAVEDMRNRWCSYLGQEMEPNLQEKLTDFLPKLLDCSTEIKSFHEPPKLPSYSTLELFERFGRVMTSLTMGRTPADGR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:1904888 (cranial skeletal system development), GO:0003002 (regionalization), GO:0009953 (dorsal/ventral pattern formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Neuroligin-1 isoform X2 (A0A8M6Z1K4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Single-pass type I membrane protein
InterPro domains:
- IPR019819: Carboxylesterase type B, conserved site (conserved_site) [152-162]
- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [45-643]
- IPR000460: Neuroligin (family) [473-724]
- IPR051093: Neuroligin and Bile salt-activated lipase (family) [45-768]
- IPR002018: Carboxylesterase, type B (domain) [53-627]
Sequence:
MPFQQPNRLSSIWKAMCPRLGLSASLDLPFLCWIVGLALHAQLAASEKLDETDPIVTTTYGKVRGFKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPISWSEIRNATQFAPVCPQTLLEGRLPDVMLPVWFTNSIEVVSSYVQDQSEDCLFLNIYVPTEDGPLSKKQNDDLADNDGAEDEDIRESGSPKPVMVFVHGGSYMEGTGNMFDGSILASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIAFFGGDPLRITVFGSGAGASCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLAKKVGCNLKDTVEMVECLQKKHYKELVEQDIQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVELIVDNENGVQANDFDYAVSSFVDDLYGYPEGKDILRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSSFGSPTYFYAFYHHCQTEQVPPWADAAHGDEIPYVFGLPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYNQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHSLNEVSQIISTTKLPPPEVTPRTPKKIPVNTKRPYPTPFPTETQDSHNQNQNQPFLVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHEVHRRCSPQRTTANELPHTQEEEIMSLQMKHSDLERECREAMHPHEVVLRTACPPDYTLAMRRSPDDIPLMTPNTITMIPNSMPGLTSLHPFNSYSSGQNNTLPHPHPHSHSTTRV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0050839 (cell adhesion molecule binding), GO:0005102 (signaling receptor binding), GO:0042043 (neurexin family protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0002040 (sprouting angiogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0045211 (postsynaptic membrane), GO:0098590 (plasma membrane region), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane), GO:0060076 (excitatory synapse), GO:0098978 (glutamatergic synapse)
Protein: ARF GTPase-activating protein GIT1 isoform X3 (A0A8M3AHJ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR022018: ARF GTPase-activating protein GIT1, C-terminal (domain) [548-661]
- IPR013724: GIT, Spa2 homology (SHD) domain (domain) [273-367]
- IPR032352: Arf GTPase-activating protein GIT1/2, coiled-coil domain (domain) [416-470]
- IPR002110: Ankyrin repeat (repeat) [132-228]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [43-247]
- IPR001164: Arf GTPase activating protein (domain) [1-124]
- IPR037278: ARFGAP/RecO-like zinc finger (homologous_superfamily) [4-120]
- IPR038508: ArfGAP domain superfamily (homologous_superfamily) [1-121]
- IPR047161: ARF GTPase-activating protein Git-like (family) [1-470]
Sequence:
MSRKVQRSEVCADCSAPDPGWSSINRGVLICDECCSVHRSLGRHISIVKHLRHSGWPPSLLQMVQTLASNGANSIWEHSLLDPAQVQSGRRKPNPQDKVHPTKSEFIRAKYQMLAFVHKLPCRDDDGVTTKDLSKQLHSSVRTGSLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQVLQAELLVVYGADPGAPDINGRTPIDYARQAGHVELAERLVECQYELTDRLAFYLCGRRPDHKNGHYIIPQMADRARPKCPTQSLDLSELAKAAKKKLQALNNRLFEELAMDVYDEVDRRENDAVWLTTQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSDAKRRQHGKGLTSPTDPLDLSQVDDDQHDYDSVASDEDTDSELTAQNNNNTQRNNRAKSMDSSDLSDGPITLQEYLEVKKALASSEAKVQQLMKVNNNLSEELRRLQKEVRKGAPAGPTPYGGAHLSASTDGRYNHPKAGEKYGSGTDSDYDNSQTYDVSIGVGRSSEEDSRGDVDDTEGDPDPTLPCTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALDAVRSSLKLLAASASRLQVECRKAAPSDSSASTVDYQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005911 (cell-cell junction)
Protein: Cyclin-dependent kinase 10 isoform X1 (A0A8M3AZU9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR050108: Cyclin-dependent kinase (family) [37-204]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [160-172]
- IPR000719: Protein kinase domain (domain) [40-304]
- IPR044093: Cyclin-dependent kinase 10, catalytic domain (domain) [32-320]
- IPR017441: Protein kinase, ATP binding site (binding_site) [46-69]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [34-311]
Sequence:
MESTADTDLEPLKLKSLKTDRTFVIPHSERLGKCRSVKEFEKINRIGEGTYGIVYRARDTRTNEIVALKKVRMDKEKDGIPISSLREINLLIRLRHPNIVELKEVVVGSHLESLFLVMSYCEQDLASLLENMQSPFSEAQVKCIVLQLLKGLAYLHHNFILHRDLKVSNLLMTDKGCVKIADFGLARVYGIPLQPMTPRVVTLWAVGCIFAELLAHKPLLPGASEIQQLDLIVQLLGTPNESIWPGFSRLPLVGQYSLRKQPYNNLKNKFTWLSEAGLRLLNLLFMYNPQRRATAIDCLESSYFKEKPLPCEPELMPTFPHHRNKRSASETEHQTKRSKV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:1901214 (regulation of neuron death), GO:1901215 (negative regulation of neuron death), GO:0007399 (nervous system development), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0043066 (negative regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0043524 (negative regulation of neuron apoptotic process), GO:0043523 (regulation of neuron apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X3 (A0A8M2BBH2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
InterPro domains:
- IPR009071: High mobility group box domain (domain) [65-135]
- IPR036910: High mobility group box domain superfamily (homologous_superfamily) [59-166]
Sequence:
MSKRPPYAPAPTPAPTTQMPTTPGFVGYNPYSHLAYNNYRLGGNPSGNNRVMNSSGITVPKPPKPPDKPLMPYMRYSRKVWDQVKASNPDLKLWEIGKIIGGMWRDLTDEEKQDYLNEYEAEKIEYNDSLKAYHNSPAYLAYVNAKNRAEAALEEESRQRQSRLDKGEPYMSIQPAEDPDDYDDGFSMKHTAAARFQRNHRLISDILSEVVVPDVRSVVTTARMQVLKRQVQSLMVHQRKLEAELLQIEDRHQEKKRRFLESTDSFNNELKRLCGLKVEVDMEKLAAEMAAAEEAARRRAEEREREAAEQVERAAQEEQQPASAQANANTEQTSASETKDGEDKPTPMETESLAETSEGSQEAEQGTPAAGEKAAQPEPAEGATDEGTSDSTAPSESSSGPPAEHQTASDNTPEERLPTQPQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048731 (system development), GO:0003157 (endocardium development), GO:0048513 (animal organ development), GO:0007507 (heart development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: RNA helicase (A0A8M3B2Q5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm
InterPro domains:
- IPR001650: Helicase, C-terminal domain-like (domain) [461-622]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [183-627]
- IPR011545: DEAD/DEAH-box helicase domain (domain) [247-437]
- IPR014014: RNA helicase, DEAD-box type, Q motif (domain) [223-251]
- IPR000629: ATP-dependent RNA helicase DEAD-box, conserved site (conserved_site) [392-400]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [242-465]
Sequence:
MSHVVVDGSHGLDQQLAVLDLNSADGQGVGTGRRYIPPHLRNKDASKNDSPGWDGSRTNGFVNGYHDSRMNGTANFARGPLRNDRGGRGGFRGNRNGASFNQPVHNAGYGTYENKDGGWNSVVNRDAYASFGGRSDRGKSAFFNDRGASSRGRYERGGFGGGTGGNSRWVEESRDEEDWSKPMPPNERLEHELFSASNTGINFEKYDDIPVEATGTNSPGHIESFHDVDMGEIIMGNITLSRYTRPTPVQKYAIPIIKTKRDLMACAQTGSGKTAAFLLPVLSQIYSEGPGEALQATKASTQENGKYVRRKQYPISLVLAPTRELALQIYDEARKFAYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGSRQTMMFSATFPKEIQILARDFLEEYIFLAVGRVGSTSENITQKVVWVEENDKRSFLLDLLNATGKDSLTLVFVETKKGADALEDFLYREGYACTSIHGDRSQRDREEALHQFRSGRCPIMVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFYNDKNSNITKDLLDILVEAKQEVPSWLENLAYEHQHKSTNRGRPKRFSGGFGARDYRQMPGGGNTFGNRGARNTGGHGGNRGFGGNKGGFGSFGGDSYGGTYGNYGGNYTQVDWWGN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0050900 (leukocyte migration), GO:0042330 (taxis), GO:0097529 (myeloid leukocyte migration), GO:0006935 (chemotaxis), GO:0030595 (leukocyte chemotaxis), GO:0070887 (cellular response to chemical stimulus), GO:0016477 (cell migration), GO:0071621 (granulocyte chemotaxis), GO:0060326 (cell chemotaxis), GO:0097530 (granulocyte migration), GO:1990266 (neutrophil migration), GO:0030593 (neutrophil chemotaxis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0043229 (intracellular organelle), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0045495 (pole plasm), GO:0043228 (non-membrane-bounded organelle), GO:0043186 (P granule), GO:0060293 (germ plasm), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: Histamine H1 receptor (A0A8M3B6M8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
InterPro domains:
- IPR000921: Histamine H1 receptor (family) [179-530]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [68-515]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [53-523]
Sequence:
MCFLTTLTSCDTLERPMESTTTLTTANSQFKRIDNTTLLIPSAPLHHHINNAVLGIFLGMLSLLTVIMNLLVLFAVRKERTLHTVGNLYIVSLSIADLIVGATVMPLNLVYLLEDQWKLGHVVCQFWLVMDYVASTASIFSLFILCLDRYRSVRHPLQYLKYRTRGRATLLICSAWLLSMTWTIPILGWRMFASVDKKTELENQCDTDFRFVTWFKVLTAILNFYIPSFLMLVFYSQIFIAVRDHYREWENFAGPALKTDATDTLTNGLQLQITKASEKESLALNAYSQNEGLLDQYSLEQPYNSRENTEEMISEPKRKMCYKKKAIFNLSKRMRKSVPDSEISFQSDDGETVAEGRPSLSLAFLQSENTAQPQTFINVSDCNVLVPNSVGNICESTPTVDIHNYTAVLCTPPSPPSPWAENSPPLDASIALPAKQSWQKLCEQSKQSIHSMRIRKERKAARQLGFIIGVFMVCWIPYFITFMVMALCETCVHHDLHMFTIWLGYINSTLNPFIYPLCNENFKRVFKKIFHMSR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008227 (G protein-coupled amine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0021517 (ventral spinal cord development), GO:0021510 (spinal cord development), GO:0022008 (neurogenesis), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0021515 (cell differentiation in spinal cord), GO:0030182 (neuron differentiation), GO:0021522 (spinal cord motor neuron differentiation), GO:0021953 (central nervous system neuron differentiation), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Stress-activated protein kinase JNK (A0A8M2B8D5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity
Subcellular location: Cytoplasm
InterPro domains:
- IPR003527: Mitogen-activated protein (MAP) kinase, conserved site (conserved_site) [102-204]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [188-200]
- IPR000719: Protein kinase domain (domain) [67-362]
- IPR050117: Mitogen-activated protein (MAP) kinase (family) [65-388]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [55-384]
- IPR008351: Mitogen-activated protein (MAP) kinase, JNK (family) [117-376]
Sequence:
MVFMNRRFLYNCSAPVLDVKIAFCQGFGKQVDVSYIAQHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAGYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDMWSVGCIFGEVIRGTVLFPGTDHIDQWNKVIEQLGTPSPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDCLFPADSEHNKLKASQARDLLSKMLIIDPAKRISVDEALQHPYINVWYDPAEVEAARNQQISMPPPQIYDKQLDEREHSIDEWKELIYKEVMNFEERTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLETSAGPLGCCR
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0004707 (MAP kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0048483 (autonomic nervous system development), GO:0007399 (nervous system development), GO:0061008 (hepaticobiliary system development), GO:0048484 (enteric nervous system development), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)