Protein: Ubiquitin-like modifier-activating enzyme 5 (A0A804HJ86)
Organism: Homo sapiens (Human)
Subcellular location: Golgi apparatus
InterPro domains:
- IPR035985: Ubiquitin-activating enzyme-like (homologous_superfamily) [105-422]
- IPR045886: ThiF/MoeB/HesA family (family) [99-387]
- IPR029752: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 (conserved_site) [133-161]
- IPR000594: THIF-type NAD/FAD binding fold (domain) [110-361]
Sequence:
MRGSDVCDAPEAAPRKACGSLGDVSVCEALGARPQGSGLGRRRRRPGLGALAAGVPAMAESVERLQQRVQELERELAQERSLQVPRSGDGGGGRVRIEKMSSEVVDSNPYSRLMALKRMGIVSDYEKIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKVQAAEHTLRNINPDVLFEVHNYNITTVENFQHFMDRISNGGLEEGKPVDLVLSCVDNFEARMTINTACNELGQTWMESGVSENAVSGHIQLIIPGESACFACAPPLVVAANIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLNFGTVSFYLGYNAMQDFFPTMSMKPNPQCDDRNCRKQQEEYKKKVAALPKQEVIQEEEEIIHEDNEWGIELVSEVSEEELKNFSGPVPDLPEGITVAYTIPKKQEDSVTELTVEDSGESLEDLMAKMKNM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016874 (ligase activity), GO:0008641 (ubiquitin-like modifier activating enzyme activity), GO:0043167 (ion binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0046983 (protein dimerization activity), GO:0016877 (ligase activity, forming carbon-sulfur bonds), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0042803 (protein homodimerization activity), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0071840 (cellular component organization or biogenesis), GO:0044238 (primary metabolic process), GO:0006950 (response to stress), GO:0061919 (process utilizing autophagic mechanism), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0003008 (system process), GO:1901564 (organonitrogen compound metabolic process), GO:0010646 (regulation of cell communication), GO:0033554 (cellular response to stress), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0009966 (regulation of signal transduction), GO:0016043 (cellular component organization), GO:0050877 (nervous system process), GO:0043170 (macromolecule metabolic process), GO:0006914 (autophagy), GO:0033143 (regulation of intracellular steroid hormone receptor signaling pathway), GO:0036211 (protein modification process), GO:0016236 (macroautophagy), GO:0034976 (response to endoplasmic reticulum stress), GO:0050905 (neuromuscular process), GO:0043412 (macromolecule modification), GO:0006996 (organelle organization), GO:0022411 (cellular component disassembly), GO:0033146 (regulation of intracellular estrogen receptor signaling pathway), GO:0070647 (protein modification by small protein conjugation or removal), GO:0061912 (selective autophagy), GO:1903008 (organelle disassembly), GO:0032446 (protein modification by small protein conjugation), GO:0061709 (reticulophagy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)