Protein: Mast/stem cell growth factor receptor (A0A8I5KS03)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein
InterPro domains:
- IPR027263: Mast/stem cell growth factor receptor (family) [1-977]
- IPR050122: Receptor Tyrosine Kinase (family) [143-931]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [789-801]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [591-923]
- IPR013151: Immunoglobulin-like beta-sandwich domain (domain) [220-303]
- IPR000719: Protein kinase domain (domain) [590-938]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [1-519]
- IPR003598: Immunoglobulin subtype 2 (domain) [224-298]
- IPR001824: Tyrosine-protein kinase, receptor class III, conserved site (conserved_site) [649-662]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [212-506]
- IPR007110: Immunoglobulin-like domain (domain) [212-309]
- IPR017441: Protein kinase, ATP binding site (binding_site) [596-624]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [590-925]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [565-924]
- IPR003599: Immunoglobulin domain subtype (domain) [43-411]
Sequence:
MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0038023 (signaling receptor activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0019955 (cytokine binding), GO:0046983 (protein dimerization activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0042802 (identical protein binding), GO:0016301 (kinase activity), GO:0042803 (protein homodimerization activity), GO:0019199 (transmembrane receptor protein kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004713 (protein tyrosine kinase activity), GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0022414 (reproductive process), GO:0002376 (immune system process), GO:0009605 (response to external stimulus), GO:0019953 (sexual reproduction), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0042330 (taxis), GO:0008283 (cell population proliferation), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048066 (developmental pigmentation), GO:0007165 (signal transduction), GO:0051640 (organelle localization), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0001775 (cell activation), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0050900 (leukocyte migration), GO:0098727 (maintenance of cell number), GO:0009893 (positive regulation of metabolic process), GO:0002252 (immune effector process), GO:0065009 (regulation of molecular function), GO:0030029 (actin filament-based process), GO:0140352 (export from cell), GO:0019827 (stem cell population maintenance), GO:0051094 (positive regulation of developmental process), GO:0048609 (multicellular organismal reproductive process), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0048468 (cell development), GO:0002366 (leukocyte activation involved in immune response), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0001817 (regulation of cytokine production), GO:0006793 (phosphorus metabolic process), GO:0070661 (leukocyte proliferation), GO:0051656 (establishment of organelle localization), GO:0030595 (leukocyte chemotaxis), GO:0002697 (regulation of immune effector process), GO:1990849 (vacuolar localization), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0032940 (secretion by cell), GO:0002443 (leukocyte mediated immunity), GO:0007166 (cell surface receptor signaling pathway), GO:0045595 (regulation of cell differentiation), GO:0007548 (sex differentiation), GO:0016043 (cellular component organization), GO:0001819 (positive regulation of cytokine production), GO:0006935 (chemotaxis), GO:0016477 (cell migration), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0097529 (myeloid leukocyte migration), GO:0002764 (immune response-regulating signaling pathway), GO:0009967 (positive regulation of signal transduction), GO:0045597 (positive regulation of cell differentiation), GO:0050790 (regulation of catalytic activity), GO:0007276 (gamete generation), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0051649 (establishment of localization in cell), GO:0030036 (actin cytoskeleton organization), GO:0010033 (response to organic substance), GO:0043170 (macromolecule metabolic process), GO:0043299 (leukocyte degranulation), GO:0007283 (spermatogenesis), GO:0050776 (regulation of immune response), GO:0042127 (regulation of cell population proliferation), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0002702 (positive regulation of production of molecular mediator of immune response), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0002263 (cell activation involved in immune response), GO:0009889 (regulation of biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0050931 (pigment cell differentiation), GO:0002274 (myeloid leukocyte activation), GO:0002699 (positive regulation of immune effector process), GO:0080090 (regulation of primary metabolic process), GO:0046661 (male sex differentiation), GO:0045834 (positive regulation of lipid metabolic process), GO:0032418 (lysosome localization), GO:0002720 (positive regulation of cytokine production involved in immune response), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0008406 (gonad development), GO:0046546 (development of primary male sexual characteristics), GO:0030318 (melanocyte differentiation), GO:1904892 (regulation of receptor signaling pathway via STAT), GO:0010468 (regulation of gene expression), GO:0043412 (macromolecule modification), GO:0006887 (exocytosis), GO:0002444 (myeloid leukocyte mediated immunity), GO:0090218 (positive regulation of lipid kinase activity), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:0019221 (cytokine-mediated signaling pathway), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0030097 (hemopoiesis), GO:0061458 (reproductive system development), GO:0034097 (response to cytokine), GO:0043303 (mast cell degranulation), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0002521 (leukocyte differentiation), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0071310 (cellular response to organic substance), GO:0051336 (regulation of hydrolase activity), GO:0002718 (regulation of cytokine production involved in immune response), GO:0031532 (actin cytoskeleton reorganization), GO:0046903 (secretion), GO:0010628 (positive regulation of gene expression), GO:0006796 (phosphate-containing compound metabolic process), GO:1904894 (positive regulation of receptor signaling pathway via STAT), GO:0051147 (regulation of muscle cell differentiation), GO:0030099 (myeloid cell differentiation), GO:0051149 (positive regulation of muscle cell differentiation), GO:0036211 (protein modification process), GO:0060326 (cell chemotaxis), GO:0045576 (mast cell activation), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0016192 (vesicle-mediated transport), GO:0002275 (myeloid cell activation involved in immune response), GO:0051338 (regulation of transferase activity), GO:0019216 (regulation of lipid metabolic process), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0051174 (regulation of phosphorus metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling), GO:0046427 (positive regulation of receptor signaling pathway via JAK-STAT), GO:0061081 (positive regulation of myeloid leukocyte cytokine production involved in immune response), GO:0046425 (regulation of receptor signaling pathway via JAK-STAT), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0071345 (cellular response to cytokine stimulus), GO:0051345 (positive regulation of hydrolase activity), GO:0016310 (phosphorylation), GO:0007010 (cytoskeleton organization), GO:0043549 (regulation of kinase activity), GO:0060191 (regulation of lipase activity), GO:0002448 (mast cell mediated immunity), GO:0051150 (regulation of smooth muscle cell differentiation), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0043410 (positive regulation of MAPK cascade), GO:0002573 (myeloid leukocyte differentiation), GO:0045055 (regulated exocytosis), GO:0031401 (positive regulation of protein modification process), GO:0043408 (regulation of MAPK cascade), GO:0038093 (Fc receptor signaling pathway), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0071944 (cell periphery), GO:0001650 (fibrillar center), GO:0031974 (membrane-enclosed lumen), GO:0005576 (extracellular region), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)