Protein: Tyrosine-protein kinase (A6JRN2)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endomembrane system; Peripheral membrane protein
InterPro domains:
- IPR008266: Tyrosine-protein kinase, active site (active_site) [998-1010]
- IPR020776: Tyrosine-protein kinase, non-receptor Jak1 (family) [223-800]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [584-1146]
- IPR016251: Tyrosine-protein kinase, non-receptor Jak/Tyk2 (family) [7-1151]
- IPR041046: JAK, FERM F2 lobe domain (domain) [147-277]
- IPR000719: Protein kinase domain (domain) [582-1152]
- IPR000980: SH2 domain (domain) [437-545]
- IPR017441: Protein kinase, ATP binding site (binding_site) [880-907]
- IPR019749: Band 4.1 domain (domain) [32-286]
- IPR000299: FERM domain (domain) [34-420]
- IPR051286: Janus Kinase (JAK) (family) [13-1152]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [582-1148]
- IPR041381: JAK1-3/TYK2, pleckstrin homology-like domain (domain) [284-421]
- IPR035963: FERM superfamily, second domain (homologous_superfamily) [147-280]
- IPR019748: FERM central domain (domain) [154-277]
- IPR041155: FERM F1 lobe ubiquitin-like domain (domain) [39-128]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [421-550]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [565-1145]
Sequence:
MQYLNIKEDCNAMAFCAKMRSFKKTEVKQVAPEPGVEVTFYLLDREPLRLGSGEYTAEELCIRAAQECSISPLCHNLFALYDESTKLWYAPNHIITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKVPEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNVLPVEKEKNKLKRKKLDYNKHKKEDDRNKLREEWNSFSYFPEITHIVIKESVVSINKQDNKNMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVSCFEKSEVLGNQKQFKNFQIEVQKGRYSLHGSVDHFPSLRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDDEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSVLTRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKQPITEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLSCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGFEALLK
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0051427 (hormone receptor binding), GO:0005126 (cytokine receptor binding), GO:0001664 (G protein-coupled receptor binding), GO:0005131 (growth hormone receptor binding), GO:0042379 (chemokine receptor binding), GO:0048020 (CCR chemokine receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048519 (negative regulation of biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0002376 (immune system process), GO:0048856 (anatomical structure development), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0051241 (negative regulation of multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0008219 (cell death), GO:0040017 (positive regulation of locomotion), GO:0023051 (regulation of signaling), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0032879 (regulation of localization), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0044238 (primary metabolic process), GO:0051047 (positive regulation of secretion), GO:2000145 (regulation of cell motility), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0044057 (regulation of system process), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0001817 (regulation of cytokine production), GO:0009725 (response to hormone), GO:1903523 (negative regulation of blood circulation), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0050865 (regulation of cell activation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045597 (positive regulation of cell differentiation), GO:0050790 (regulation of catalytic activity), GO:1903829 (positive regulation of protein localization), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0043170 (macromolecule metabolic process), GO:2000147 (positive regulation of cell motility), GO:0009891 (positive regulation of biosynthetic process), GO:0050867 (positive regulation of cell activation), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0031325 (positive regulation of cellular metabolic process), GO:0033554 (cellular response to stress), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0099177 (regulation of trans-synaptic signaling), GO:0080090 (regulation of primary metabolic process), GO:0010942 (positive regulation of cell death), GO:0032103 (positive regulation of response to external stimulus), GO:0012501 (programmed cell death), GO:0060548 (negative regulation of cell death), GO:0032388 (positive regulation of intracellular transport), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0030155 (regulation of cell adhesion), GO:0071495 (cellular response to endogenous stimulus), GO:0051098 (regulation of binding), GO:0006793 (phosphorus metabolic process), GO:0007204 (positive regulation of cytosolic calcium ion concentration), GO:0009755 (hormone-mediated signaling pathway), GO:0007162 (negative regulation of cell adhesion), GO:0097190 (apoptotic signaling pathway), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0001819 (positive regulation of cytokine production), GO:0031349 (positive regulation of defense response), GO:0008284 (positive regulation of cell population proliferation), GO:0009967 (positive regulation of signal transduction), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0009611 (response to wounding), GO:0046887 (positive regulation of hormone secretion), GO:0006979 (response to oxidative stress), GO:0006952 (defense response), GO:0030522 (intracellular receptor signaling pathway), GO:0036473 (cell death in response to oxidative stress), GO:0010817 (regulation of hormone levels), GO:0010033 (response to organic substance), GO:0046883 (regulation of hormone secretion), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0009889 (regulation of biosynthetic process), GO:0051222 (positive regulation of protein transport), GO:0031099 (regeneration), GO:1903532 (positive regulation of secretion by cell), GO:0030030 (cell projection organization), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:1904951 (positive regulation of establishment of protein localization), GO:0048545 (response to steroid hormone), GO:0046824 (positive regulation of nucleocytoplasmic transport), GO:0031102 (neuron projection regeneration), GO:0010468 (regulation of gene expression), GO:0043401 (steroid hormone mediated signaling pathway), GO:0048660 (regulation of smooth muscle cell proliferation), GO:0043412 (macromolecule modification), GO:0051223 (regulation of protein transport), GO:0032732 (positive regulation of interleukin-1 production), GO:0030335 (positive regulation of cell migration), GO:0097193 (intrinsic apoptotic signaling pathway), GO:1902533 (positive regulation of intracellular signal transduction), GO:1900182 (positive regulation of protein localization to nucleus), GO:0022408 (negative regulation of cell-cell adhesion), GO:0043085 (positive regulation of catalytic activity), GO:0050708 (regulation of protein secretion), GO:1901701 (cellular response to oxygen-containing compound), GO:0019221 (cytokine-mediated signaling pathway), GO:0032386 (regulation of intracellular transport), GO:0071417 (cellular response to organonitrogen compound), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0071310 (cellular response to organic substance), GO:0062197 (cellular response to chemical stress), GO:0050804 (modulation of chemical synaptic transmission), GO:1901699 (cellular response to nitrogen compound), GO:0048661 (positive regulation of smooth muscle cell proliferation), GO:1901214 (regulation of neuron death), GO:0032880 (regulation of protein localization), GO:0045822 (negative regulation of heart contraction), GO:0036211 (protein modification process), GO:0043434 (response to peptide hormone), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0022008 (neurogenesis), GO:0032870 (cellular response to hormone stimulus), GO:0033993 (response to lipid), GO:0031326 (regulation of cellular biosynthetic process), GO:0006915 (apoptotic process), GO:0051101 (regulation of DNA binding), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0034599 (cellular response to oxidative stress), GO:1901652 (response to peptide), GO:0031347 (regulation of defense response), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0022407 (regulation of cell-cell adhesion), GO:0070201 (regulation of establishment of protein localization), GO:0002793 (positive regulation of peptide secretion), GO:0030334 (regulation of cell migration), GO:1903522 (regulation of blood circulation), GO:0048666 (neuron development), GO:0014857 (regulation of skeletal muscle cell proliferation), GO:0090276 (regulation of peptide hormone secretion), GO:0007399 (nervous system development), GO:0050729 (positive regulation of inflammatory response), GO:0051252 (regulation of RNA metabolic process), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:1904407 (positive regulation of nitric oxide metabolic process), GO:1901215 (negative regulation of neuron death), GO:0034097 (response to cytokine), GO:0090316 (positive regulation of intracellular protein transport), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0051336 (regulation of hydrolase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0099572 (postsynaptic specialization), GO:0098984 (neuron to neuron synapse), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0031981 (nuclear lumen), GO:0032279 (asymmetric synapse), GO:0005634 (nucleus)