Protein: Sodium-dependent multivitamin transporter (Q5U4D8)
Organism: Mus musculus (Mouse)
Function: Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide . Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (By similarity). Required for biotin and pantothenate uptake in the intestine across the brush border membrane. Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin. Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Apical cell membrane ; Multi-pass membrane protein
InterPro domains:
- IPR051163: Sodium:Solute Symporter (SSF) (family) [21-576]
- IPR038377: Sodium/glucose symporter superfamily (homologous_superfamily) [52-551]
- IPR001734: Sodium/solute symporter (family) [24-476]
- IPR018212: Sodium/solute symporter, conserved site (conserved_site) [172-197]
Sequence:
MSVASTAAPFHTTSGSSGAISTFSVVDYVVFGLLLVLSLVIGLYHACRGWGHHTVGELLMADRKMGCLPVALSLLATFQSAVAILGAPAEIFRFGTQYWFLGCSYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKAVRICGTVTFIFQMVIYMGVALYAPSLALNAVTGFDLWLSVLALGIVCNIYTALGGLKAVIWTDVFQTLVMFLGQLVVIIVGAARVGGLGHVWNVTSQHGLISGINLDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQRYLSSHSERAAVLSCYAVFPCQQVALCMSCLIGLVMFAYYNMYSMSPELKQAAPDQLVLYFVMDLLKDMPGLPGLFVACLFSGSLSTISSAFNSLATVTMEDLIQPWFPQLTETRAIMLSRGLAFAYGLVCLGMAYISSHLGSVLQAALSIFGMVGGPLLGLFCLGLFFPCANPLGAIVGLLTGLTMAFWIGIGSIVSRMSSAVAPPPLNGSSSFLPANVTVAAVTTVMPSTLSKPTGLQHFYSLSYLWYSAHNSTTVIVVGLIVSLLTGGMRGRSLNPGTIYPVLPKLLALLPLSCQKRLCWRSHSQDIPVIPNLFPEKMRNGVLQDSTDKERMAEDGLVHQPCSPTYVVQETSL
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015296 (monoatomic anion:monoatomic cation symporter activity), GO:0015293 (symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015370 (solute:sodium symporter activity), GO:0015373 (monoatomic anion:sodium symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0055085 (transmembrane transport), GO:0051234 (establishment of localization), GO:0003008 (system process), GO:1903825 (organic acid transmembrane transport), GO:0098739 (import across plasma membrane), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0003013 (circulatory system process), GO:0035461 (vitamin transmembrane transport), GO:0003018 (vascular process in circulatory system), GO:0098657 (import into cell), GO:0071705 (nitrogen compound transport), GO:0010232 (vascular transport), GO:0051180 (vitamin transport), GO:0071702 (organic substance transport), GO:0072348 (sulfur compound transport), GO:0098656 (monoatomic anion transmembrane transport), GO:0098661 (inorganic anion transmembrane transport), GO:1905039 (carboxylic acid transmembrane transport), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0150104 (transport across blood-brain barrier), GO:0042886 (amide transport), GO:0015711 (organic anion transport), GO:0072337 (modified amino acid transport), GO:0015849 (organic acid transport), GO:0006820 (monoatomic anion transport), GO:0046942 (carboxylic acid transport), GO:0015718 (monocarboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045177 (apical part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane)