Protein: Hedgehog protein (A6JVX0)
Organism: Rattus norvegicus (Rat)
Function: [Protein hedgehog N-product]: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development
Subcellular location: Endoplasmic reticulum membrane. Membrane; Lipid-anchor. Secreted
InterPro domains:
- IPR003587: Hint domain N-terminal (domain) [201-308]
- IPR050387: Hedgehog Signaling (family) [14-405]
- IPR001657: Hedgehog protein (family) [9-403]
- IPR006141: Intein N-terminal splicing region (ptm) [203-279]
- IPR000320: Hedgehog, N-terminal signalling domain (domain) [28-189]
- IPR001767: Hedgehog protein, Hint domain (domain) [191-396]
- IPR003586: Hint domain C-terminal (domain) [309-353]
- IPR009045: Peptidase M74/Hedgehog-like, zinc-binding domain superfamily (homologous_superfamily) [25-198]
- IPR036844: Hint domain superfamily (homologous_superfamily) [203-349]
Sequence:
MSPAWLRPRLRFCLLLLLLLLVPAARGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGGCFPAGAQVHLETGERVALSAVKPGDRVLAMGEDGNPTFSDVLIFLDREPNRLRAFQVIETQDPPRRLALTPAHLLFIADNHTEPAARFRATFASHVQPGQYVLVAGVPGLQPARVAAISTHVALGSYAPLTRHGTLVVEDVVASCFAAVSDHHLAQLAFWPLRLFPSLPWGSWTPSEGVHWYPQLLYRLGRLLLEESTFHPLGMSGAGS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0044706 (multi-multicellular organism process), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0044703 (multi-organism reproductive process), GO:0032504 (multicellular organism reproduction), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0048522 (positive regulation of cellular process), GO:0007565 (female pregnancy), GO:0042127 (regulation of cell population proliferation), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0048731 (system development), GO:0048513 (animal organ development), GO:1901700 (response to oxygen-containing compound), GO:0009612 (response to mechanical stimulus), GO:0060135 (maternal process involved in female pregnancy), GO:0031099 (regeneration), GO:0010033 (response to organic substance), GO:0008284 (positive regulation of cell population proliferation), GO:0031100 (animal organ regeneration), GO:0032355 (response to estradiol), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0033993 (response to lipid), GO:0048732 (gland development), GO:0014070 (response to organic cyclic compound), GO:0050678 (regulation of epithelial cell proliferation), GO:0061008 (hepaticobiliary system development), GO:0050679 (positive regulation of epithelial cell proliferation), GO:0042981 (regulation of apoptotic process), GO:0001889 (liver development), GO:0043066 (negative regulation of apoptotic process), GO:0097421 (liver regeneration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0031012 (extracellular matrix)