lokahq/bioreason-rl huggingface dataset:
Protein: Acyl-CoA-binding domain-containing protein 5 (A0A7I2V2M2)
Organism: Homo sapiens (Human)
Function: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters
Subcellular location: Membrane; Single- pass membrane protein. Peroxisome membrane; Single-pass membrane protein
InterPro domains:
- IPR022408: Acyl-CoA-binding protein, ACBP, conserved site (conserved_site) [30-48]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [6-103]
- IPR035984: Acyl-CoA binding protein superfamily (homologous_superfamily) [9-94]
- IPR000582: Acyl-CoA-binding protein, ACBP (domain) [8-97]
- IPR016347: Acyl-CoA-binding domain-containing protein 5 (family) [1-472]
Sequence:
MADTRSVHETRFEAAVKVIQSLPKNGSFQPTNEMMLKFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKIIETMPMTEKVEELLRVIGPFYEIVEDKKSGRSSDITSAESSDSGAESEEEEAQEEVKGAEQSDNDKKMMKKSADHKNLEVIVTNGYDKDGFVQDIQNDIHASSSLNGRSTEEVKPIDENLGQTGKSAVCIHQDINDDHVEDVTGIQHLTSDSDSEVYCDSMEQFGQEESLDSFTSNNGPFQYYLGGHSSQPMENSGFREDIQVPPGNGNIGNMQVVAVEGKGEVKHGGEDGRNNSGAPHREKRGGETDEFSNVRRGRGHRMQHLSEGTKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLMRLQEDMQNVLQRLQKLETLTALQAKSSTSTLQTAPQPTSQRPSWWPFEMSPGVLTFAIIWPFIAQWLVYLYYQRRRRKLN
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0044248 (cellular catabolic process), GO:0006914 (autophagy), GO:0030242 (autophagy of peroxisome)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0042579 (microbody), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Hyccin PI4KA lipid kinase complex subunit 1 (A0A7P0T8K2)
Organism: Homo sapiens (Human)
Subcellular location: Cell membrane. Membrane
InterPro domains:
- IPR018619: Hyccin (family) [1-312]
Sequence:
MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSELLEPVCHQLFEFYRSGEEQLLQFTLQFLPELIWCYLAVSASRNVHSSGCIEALLLGVYNLEIVDKQGHTKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQHVRKYKGISSRIPVSSGFMVQMLTGIYFALAQLELYPEPLLVANAIKASLPHGPMKSNKEGTRCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGNTELTGQEELMEISEVDEGFYSRAASSTSQSGLSNSSHNCSNKPSIGKNHRRSGGSKTGGKEKETTGESCKDHFARKQTQRAQSENLELLSLKRLTLTTSQSLPKPSSHGLAKTAATVFSKSFEQVSGVTVPHNPSSAVGCGAGTDANRFSACSLQEEKLIYVSERTELPMKHQSGQQRPPSISITLSTD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051641 (cellular localization), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0044255 (cellular lipid metabolic process), GO:0070727 (cellular macromolecule localization), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0051668 (localization within membrane), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072657 (protein localization to membrane), GO:0008104 (protein localization), GO:0046486 (glycerolipid metabolic process), GO:0008610 (lipid biosynthetic process), GO:0006644 (phospholipid metabolic process), GO:0045017 (glycerolipid biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0006650 (glycerophospholipid metabolic process), GO:0046474 (glycerophospholipid biosynthetic process), GO:0008654 (phospholipid biosynthetic process), GO:1990778 (protein localization to cell periphery), GO:0072659 (protein localization to plasma membrane), GO:0006661 (phosphatidylinositol biosynthetic process), GO:0046488 (phosphatidylinositol metabolic process), GO:0046854 (phosphatidylinositol phosphate biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Centrosome and spindle pole associated protein 1 (A0A7I2V3M9)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR026708: Centrosome and spindle pole associated protein 1 (family) [101-620]
- IPR058191: Centrosome and spindle pole-associated protein 1, C-terminal (domain) [885-938]
Sequence:
MADNLDEFIEEQKARLAEDKAELESDPPYMEMKGKLSAKLSENSKILISMAKENIPPNSQQTRGSLGIDYGLSLPLGEDYERKKHKLKEELRQDYRRYLTQERLKLERNKEYNQFLRGKEESSEKFRQVEKSTEPKSQRNKKPIGQVKPDLTSQIQTSCENSEGPRKDVLTPSEAYEELLNQRRLEEDRYRQLDDEIELRNRRIIKKANEEVGISNLKHQRFASKAGIPDRRFHRFNEDRVFDRRYHRPDQDPEVSEEMDERFRYESDFDRRLSRVYTNDRMHRNKRGNMPPMEHDGDVIEQSNIRISSAENKSAPDNETSKSANQDTCSPFAGMLFGGEDRELIQRRKEKYRLELLEQMAEQQRNKRREKDLELRVAASGAQDPEKSPDRLKQFSVAPRHFEEMIPPERPRIAFQTPLPPLSAPSVPPIPSVHPVPSQNEDLRSGLSSALGEMVSPRIAPLPPPPLLPPLATNYRTPYDDAYYFYGSRNTFDPSLAYYGSGMMGVQPAAYVSAPVTHQLAQPVVNTVGQNELKITSDQVINSGLIFEDKPKPSKQSLQSYQEALQQQIREREERRKKEREEKEEYEAKLEAEMRTYNPWGKGGGGAPLRDAKGNLISHMQTQSSPFARGNVFGEPPTELQIKQQELYKNFLRFQIEEKKQREEAERERLRIAEEKEERRLAEQRARIQQEYEEEQEKKREKEEEQRLKNEEHIRLAEERQKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPALQNKIASKLQRPPSVDSIIRSFIHESSMSRAQSPPVPARKNQLRAEEEKKNVIMELSEMRKQLRSEERRLQERLLHMDSDDEIPIRKKERNPMDIFDMARHRLQAPVRRQSPKGLDAATFQNVHDFNELKDRDSETRVDLKFMYLDPPRDHHTLEIQQQALLREQQKRLNRIKMQEGAKGAYGETYPAIEDDVLPPPSQLPSARERRRNKWKGLDIDSSRPNVAPDGLSLKSISSVNVDELRVRNEERMRRLNEFHNKPINTDDESSLVDPDDIMKHIGDDGSNSVATEPWLRPGTSETLKRFMAEQLNQEQQQIPGKPGTFTWQGLSTAHG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051302 (regulation of cell division), GO:0051726 (regulation of cell cycle), GO:0051781 (positive regulation of cell division), GO:0090068 (positive regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0045787 (positive regulation of cell cycle), GO:0032465 (regulation of cytokinesis), GO:0032467 (positive regulation of cytokinesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0034451 (centriolar satellite), GO:0000922 (spindle pole), GO:0005813 (centrosome), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0005819 (spindle), GO:0015630 (microtubule cytoskeleton)
Protein: Required for meiotic nuclear division 1 homolog (A0A804HHY2)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR051624: RMD1/Sad1-interacting (family) [37-336]
- IPR003734: Domain of unknown function DUF155 (domain) [226-341]
Sequence:
MPATLLRAVARSHHILSKAHQCRRIGHLMLKPLKEFENTTCSTLTIRQSLDLFLPDKTASGLNKSQILEMNQKKSDTSMLSPLNAARCQDEKAHLPTMKSFGTHRRVTHKPNLLGSKWFIKILKRHFSSVSTETFVPKQDFPQVKRPLKASRTRQPSRTNLPVLSVNEDLMHCTAFATADEYHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVKDKTMKHVMKVLEKHEIQPYEIALVHWENEELNYIKIEGQSKLHRGEIKLNSELDLDDAILEKFAFSNALCLSVKLAIWEASLDKFIESIQSIPEVMNEKLQHCMELTDLMRNHLNEKRALRLEWMIVILITIEVMFELGRVFF
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0034248 (regulation of amide metabolic process), GO:0034250 (positive regulation of amide metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0010628 (positive regulation of gene expression), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0006417 (regulation of translation), GO:0045727 (positive regulation of translation), GO:0062125 (regulation of mitochondrial gene expression), GO:0010608 (post-transcriptional regulation of gene expression), GO:0070131 (positive regulation of mitochondrial translation), GO:0070129 (regulation of mitochondrial translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Sorting nexin 14 (A0A804HIA1)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR037436: Sorting nexin-14, PX domain (domain) [468-590]
- IPR001683: Phox homology (domain) [471-594]
- IPR003114: Phox-associated domain (domain) [32-208]
- IPR013937: Sorting nexin, C-terminal (domain) [711-814]
- IPR036305: RGS domain superfamily (homologous_superfamily) [232-377]
- IPR036871: PX domain superfamily (homologous_superfamily) [461-606]
- IPR044926: RGS, subdomain 2 (homologous_superfamily) [227-382]
- IPR037892: SNX14, RGS domain (domain) [244-370]
- IPR016137: RGS domain (domain) [240-372]
Sequence:
MIFWSFVAGVVTFYCSLGPDSLLPNIFFTIKYKPKQLGLQELFPQGHSCAVCGKVKCKRHRPSLLLENYQPWLDLKISSKVDASLSEVDIPSIITKKLLKAAMKHIEVIVKARQKVKNTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLIREILSGSVFLPSLDFLADPDTVNHLLIIFIDDSPPEKATEPASPLVPFLQKFAEPRNKKPSVLKLELKQIREQQDLLFRFMNFLKQEGAVHVLQFCLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESIDKIRFDPFIVEEIQRIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKLNRGSLSLDDFRNTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGVAEGEDDFIEEGIVVMEDDSPVEAVSTPNTPRNLAAWKISIPYVDFFEDPSSERKEKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGAFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIMNFINSCESPKPKPSRPELTILSPTSENNKKLFNDLFKNNANRAENTERKQNQNYFMEVMTVEGVYDYLMYVGRVVFQVPDWLHHLLMGTRILFKNTLEMYTDYYLQCKLEQLFQEHRLVSLITLLRDAIFCENTEPRSLQDKQKGAKQTFEEMMNYIPDLLVKCIGEETKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPELNKVQKEVTSVTSWM
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0008289 (lipid binding), GO:0043168 (anion binding), GO:0005543 (phospholipid binding), GO:0080025 (phosphatidylinositol-3,5-bisphosphate binding), GO:0035091 (phosphatidylinositol binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:1902936 (phosphatidylinositol bisphosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0016043 (cellular component organization), GO:0044248 (cellular catabolic process), GO:0006914 (autophagy), GO:0016236 (macroautophagy), GO:0022411 (cellular component disassembly), GO:0043933 (protein-containing complex organization), GO:0097352 (autophagosome maturation), GO:0032984 (protein-containing complex disassembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Cathepsin F (A0A7I2V411)
Organism: Homo sapiens (Human)
Subcellular location: Lysosome
InterPro domains:
- IPR013128: Peptidase C1A (family) [201-489]
- IPR013201: Cathepsin propeptide inhibitor domain (I29) (domain) [201-258]
- IPR000169: Cysteine peptidase, cysteine active site (active_site) [303-314]
- IPR039417: Papain-like cysteine endopeptidase (domain) [286-495]
- IPR025660: Cysteine peptidase, histidine active site (active_site) [443-453]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [194-496]
- IPR000668: Peptidase C1A, papain C-terminal (domain) [285-496]
Sequence:
MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTRFALEMFNRGRAAGTRAVLGLVRGRVRRAGQGSLYSLEATLEEPPCNDPMVCRLPVSKKTLLCSFQVLDELGRHVLLRKDCGPVDTKVPGAGEPKSAFTQGSAMISSLSQNHPDNRNETFSSVISLLNEDPLSQWVSLVSLKTGLPIQDLPVKMASIFKNFVITYNRTYESKEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLTEEEFRTIYLNTLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSVTGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSYQGHMQSCNFSAEKAKVYINDSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGISRPLRPLCSPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASSAVVD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0002376 (immune system process), GO:0019882 (antigen processing and presentation), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0019884 (antigen processing and presentation of exogenous antigen), GO:0043170 (macromolecule metabolic process), GO:0002504 (antigen processing and presentation of peptide or polysaccharide antigen via MHC class II), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0048002 (antigen processing and presentation of peptide antigen), GO:0006508 (proteolysis), GO:0002495 (antigen processing and presentation of peptide antigen via MHC class II), GO:0002478 (antigen processing and presentation of exogenous peptide antigen), GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle)
Protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (A0A7I2V327)
Organism: Homo sapiens (Human)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Subcellular location: Mitochondrion matrix
InterPro domains:
- IPR050566: Deoxyribonucleoside Kinase (family) [17-320]
- IPR015828: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (family) [1-336]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [56-293]
- IPR031314: Deoxynucleoside kinase domain (domain) [60-273]
Sequence:
MALRLLKLAATSASARVVAAGAQRVRGIHSSVQCKLRYGMWHFLLGDKASKRLTERSRVITVDGNICTGKGKLAKEIAEKLGFKHFPEAGIHYPDSTTGDGKPLATDYNGNCSLEKFYDDPRSNDGNSYRLQSWLYSSRLLQYSDALEHLLTTGQGVVLERSIFSDFVFLEAMYNQGFIRKQCVDHYNEVKSVTICDYLPPHLVIYIDVPVPEVQRRIQKKGDPHEMKITSAYLQDIENAYKKTFLPEMSEKCEVLQYSAREAQDSKKVVEDIEYLKFDKGPWLKQDNRTLYHLRLLVQDKFEVLNYTSIPIFLPEVTIGAHQTDRVLHQFREDPSDGLGPTQITQMISQSPAAEALLPAAGPQVQPWVQHRGGRQVDLAEVNGPPSAPAASQ
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0022804 (active transmembrane transporter activity), GO:0008137 (NADH dehydrogenase (ubiquinone) activity), GO:0015399 (primary active transmembrane transporter activity), GO:0003954 (NADH dehydrogenase activity), GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor), GO:0015453 (oxidoreduction-driven active transmembrane transporter activity), GO:0050136 (NADH dehydrogenase (quinone) activity), GO:0003955 (NAD(P)H dehydrogenase (quinone) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0010257 (NADH dehydrogenase complex assembly), GO:0032981 (mitochondrial respiratory chain complex I assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: ATPase copper transporting alpha (A0A8I5QJP0)
Organism: Homo sapiens (Human)
InterPro domains:
- IPR017969: Heavy-metal-associated, conserved site (conserved_site) [26-424]
- IPR036163: Heavy metal-associated domain superfamily (homologous_superfamily) [20-455]
- IPR006121: Heavy metal-associated domain, HMA (domain) [20-455]
- IPR006122: Heavy metal-associated domain, copper ion-binding (domain) [22-454]
Sequence:
MKDLLECNEEIKMDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIYPQKRTVAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLS
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006810 (transport), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055070 (copper ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0006878 (intracellular copper ion homeostasis), GO:0006812 (monoatomic cation transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006825 (copper ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)