Protein: DNA (cytosine-5)-methyltransferase (A0A8M6YUX4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
InterPro domains:
- IPR043151: Bromo adjacent homology (BAH) domain superfamily (homologous_superfamily) [607-992]
- IPR002857: Zinc finger, CXXC-type (domain) [530-576]
- IPR001025: Bromo adjacent homology (BAH) domain (domain) [640-986]
- IPR031303: DNA methylase, C-5 cytosine-specific, conserved site (conserved_site) [1462-1480]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [993-1481]
- IPR022702: DNA (cytosine-5)-methyltransferase 1, replication foci domain (domain) [280-414]
- IPR001525: C-5 cytosine methyltransferase (family) [1028-1487]
- IPR050390: DNA Cytosine-5 Methyltransferase (family) [383-1495]
- IPR018117: DNA methylase, C-5 cytosine-specific, active site (active_site) [1107-1119]
- IPR010506: DMAP1-binding domain (domain) [5-104]
Sequence:
MPTKTSLSLPEDVKERLQVLDEGGDSLSDEECVKEKLRLLQEFLLADTQDQLKNLEDKLKSSELSTEVYMSEVKAVLKKALGVVKEGDGVEQNGHSNGFSENGSHKDNGEQEGAMDTQEEGDAIKSPSAPKGRGGRRSKADSEPKKSPASSRVTRNTGKQQTIVSMFSRVPKRKSDELNGEPANGDTEIKTEETITEEVREEKRLKTEDEKPEAENAANLKPVSTAKTPPPKCPDCRQYLDDSDLKFFQGDPDDALDEPEMLTDERLSLFDSNEDGFESYEDLPQHKITNFSVYDKRGHLCPFDSGLIEKNVELYFSCAVKPIYDDNPCMDGGVPAKKLGPINAWWITGFDGGEKALIGFTTAFADYILMDPSEEYSAIFALMQEKIYMSKIVVEFLQKNQDATYEDLLNKIETTVPPAGLNFNRFTEDTLLRHAQFVVEQVESYDEAGDSDEQPIIITPCMRDLIKLAGVTLGKSRQLYWRAARRQAVRHPTKIEKDNKGPTKATTTKLVYLIFDTFFSDQIDQNNKDGGVKRQRCGVCEVCQAPDCGKCSACKDMIKFGGSGRSKQACQKRRCPNLAVKEAEDDENMDEEDVLPVKDTKKMSQTKKKKQTKNKISWVGEPLKTEGKKEYYMKVRVENEVLEVGDCVSVSPDDPSHPLYLARITALWDDGEKMFHAHWFCRGTDTVLGESSDPLELFLVDECEDMQLSFIHGKVNVFYKAPSENWYMEGGMDEDIKVIDDDGESFFYQLHYEGECARFETPPKVTPSEDCKYKFCASCTRNKEREAESVPHAYEPLEDEESDSKVFYGLVNYKGEQYKVGDSVYLPPEAFNFVVKAASPVKRSHRKDDVDEDLYPEYYRKSSDYIKGSNLDAPQPFRIGRIKEIFCNKRSNGKPDTSEIKLRLYKFYRPENTHKGPKGAYHSDINQLYWSDEEATVSMTEVLTRCRVEYAEDLVESVQDYSNKGPDRFYFLEAYNAKTKSFEDPPNHARSAVNKGKGKGKGKGKGKGKAAPQEPQDQEPQEPVVPKLRTLDVFSGCGGLSEGFHQAGISETHWAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKLVMSGEKTNSLGQKLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSYLSYCDYYRPKFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPRYPEPLHVFAPRACSLSVAVDEKKYVSNVTRGNGGIYRTITVRDTMSDLPEIRNGAAALEISYNGEPQSWFQRQIRGSQYQPILRDHICKDMSALVAARMRNIPLAPGSDWRDLPNFEVRLRDGTTTKKLRYTHPDKKNGRSGTGALRGVCSCSEGKPCDPADRQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYRFFGNVLDKHRQVGNAVPPPLSKAIGLEVKKCVLEKMRENATEPVKQEKMELSD
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016740 (transferase activity), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0140097 (catalytic activity, acting on DNA), GO:0009008 (DNA-methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0003886 (DNA (cytosine-5-)-methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0032259 (methylation), GO:0007389 (pattern specification process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0060042 (retina morphogenesis in camera-type eye), GO:0046483 (heterocycle metabolic process), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0070121 (Kupffer's vesicle development), GO:0003407 (neural retina development), GO:0009799 (specification of symmetry), GO:0060255 (regulation of macromolecule metabolic process), GO:0043414 (macromolecule methylation), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0060041 (retina development in camera-type eye), GO:0043170 (macromolecule metabolic process), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:1901360 (organic cyclic compound metabolic process), GO:0002088 (lens development in camera-type eye), GO:0010842 (retina layer formation), GO:0003002 (regionalization), GO:0009888 (tissue development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0030097 (hemopoiesis), GO:0051216 (cartilage development), GO:0002521 (leukocyte differentiation), GO:0006479 (protein methylation), GO:0055123 (digestive system development), GO:0051052 (regulation of DNA metabolic process), GO:0048880 (sensory system development), GO:0061448 (connective tissue development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0048732 (gland development), GO:0035272 (exocrine system development), GO:0030099 (myeloid cell differentiation), GO:0061008 (hepaticobiliary system development), GO:0010468 (regulation of gene expression), GO:0006306 (DNA methylation), GO:0036211 (protein modification process), GO:0009855 (determination of bilateral symmetry), GO:0043412 (macromolecule modification), GO:0061009 (common bile duct development), GO:0001501 (skeletal system development), GO:0060972 (left/right pattern formation), GO:0090304 (nucleic acid metabolic process), GO:0006259 (DNA metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0048565 (digestive tract development), GO:0010629 (negative regulation of gene expression), GO:0031016 (pancreas development), GO:0008213 (protein alkylation), GO:0007368 (determination of left/right symmetry), GO:0060216 (definitive hemopoiesis), GO:0006304 (DNA modification), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0035622 (intrahepatic bile duct development), GO:0018193 (peptidyl-amino acid modification), GO:0150063 (visual system development), GO:0031017 (exocrine pancreas development), GO:0044030 (regulation of DNA methylation), GO:0001889 (liver development), GO:0018022 (peptidyl-lysine methylation), GO:0032776 (DNA methylation on cytosine), GO:0002573 (myeloid leukocyte differentiation), GO:0016571 (histone methylation), GO:0016570 (histone modification), GO:0034968 (histone lysine methylation), GO:0030851 (granulocyte differentiation), GO:0061647 (histone H3-K9 modification), GO:0006305 (DNA alkylation), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0018205 (peptidyl-lysine modification), GO:0051567 (histone H3-K9 methylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)