Protein: Nuclear factor NF-kappa-B p105 subunit (D6RH30)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasm. Nucleus
InterPro domains:
- IPR011029: Death-like domain superfamily (homologous_superfamily) [811-899]
- IPR030503: Nuclear factor NF-kappa-B, p105 subunit, Rel homology domain, N-terminal (domain) [51-252]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [256-374]
- IPR032397: Rel homology dimerisation domain (domain) [260-361]
- IPR037059: Rel homology domain (RHD), DNA-binding domain superfamily (homologous_superfamily) [50-252]
- IPR030492: Rel homology domain, conserved site (conserved_site) [66-72]
- IPR002110: Ankyrin repeat (repeat) [551-759]
- IPR000451: NF-kappa-B/Dorsal (family) [40-912]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [544-802]
- IPR011539: Rel homology domain, DNA-binding domain (domain) [48-255]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [257-389]
- IPR002909: IPT domain (domain) [258-359]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [50-261]
- IPR000488: Death domain (domain) [814-901]
- IPR047096: Nuclear factor NF-kappa-B p105 subunit, death domain (domain) [824-899]
- IPR033926: NFkappaB IPT domain (domain) [259-360]
Sequence:
MKRTTSFRMAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLG
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0060548 (negative regulation of cell death), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009314 (response to radiation), GO:0080134 (regulation of response to stress), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:2001021 (negative regulation of response to DNA damage stimulus), GO:0104004 (cellular response to environmental stimulus), GO:0010941 (regulation of cell death), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0071214 (cellular response to abiotic stimulus), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0071478 (cellular response to radiation), GO:0009416 (response to light stimulus), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0043069 (negative regulation of programmed cell death), GO:0071310 (cellular response to organic substance), GO:0043067 (regulation of programmed cell death), GO:0062197 (cellular response to chemical stress), GO:0071470 (cellular response to osmotic stress), GO:2001234 (negative regulation of apoptotic signaling pathway), GO:1902532 (negative regulation of intracellular signal transduction), GO:2001233 (regulation of apoptotic signaling pathway), GO:2001020 (regulation of response to DNA damage stimulus), GO:0010468 (regulation of gene expression), GO:1902230 (negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:2001242 (regulation of intrinsic apoptotic signaling pathway), GO:0042981 (regulation of apoptotic process), GO:1901796 (regulation of signal transduction by p53 class mediator), GO:0043066 (negative regulation of apoptotic process), GO:2001141 (regulation of RNA biosynthetic process), GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway), GO:0006355 (regulation of DNA-templated transcription), GO:0071482 (cellular response to light stimulus), GO:0009411 (response to UV), GO:1902229 (regulation of intrinsic apoptotic signaling pathway in response to DNA damage), GO:1902680 (positive regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1902253 (regulation of intrinsic apoptotic signaling pathway by p53 class mediator), GO:1902165 (regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator), GO:1902254 (negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator), GO:0045892 (negative regulation of DNA-templated transcription), GO:1902041 (regulation of extrinsic apoptotic signaling pathway via death domain receptors), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0034644 (cellular response to UV), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)