Protein: Transitional endoplasmic reticulum ATPase (A0A7P0TAQ1)
Organism: Homo sapiens (Human)
Subcellular location: Endoplasmic reticulum. Nucleus
InterPro domains:
- IPR003593: AAA+ ATPase domain (domain) [237-649]
- IPR005938: AAA ATPase, CDC48 family (family) [26-694]
- IPR041569: AAA ATPase, AAA+ lid domain (domain) [393-695]
- IPR003959: ATPase, AAA-type, core (domain) [241-647]
- IPR050168: AAA ATPase domain-containing protein (family) [38-694]
- IPR004201: CDC48, domain 2 (domain) [125-191]
- IPR029067: CDC48 domain 2-like superfamily (homologous_superfamily) [107-198]
- IPR009010: Aspartate decarboxylase-like domain superfamily (homologous_superfamily) [22-105]
- IPR003338: CDC48, N-terminal subdomain (domain) [25-108]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [200-698]
- IPR003960: ATPase, AAA-type, conserved site (conserved_site) [341-635]
Sequence:
MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRALSWPAWTLFPGGGGACPGEGPGVRPQPAPFSSLNSSATV
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0140657 (ATP-dependent activity), GO:0030234 (enzyme regulator activity), GO:0097159 (organic cyclic compound binding), GO:0016887 (ATP hydrolysis activity), GO:0140677 (molecular function activator activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0042802 (identical protein binding), GO:0008047 (enzyme activator activity), GO:0003676 (nucleic acid binding), GO:0140030 (modification-dependent protein binding), GO:0019904 (protein domain specific binding), GO:0061134 (peptidase regulator activity), GO:0019899 (enzyme binding), GO:0044389 (ubiquitin-like protein ligase binding), GO:0140035 (ubiquitination-like modification-dependent protein binding), GO:0016504 (peptidase activator activity), GO:0019902 (phosphatase binding), GO:0002020 (protease binding), GO:0031593 (polyubiquitin modification-dependent protein binding), GO:0003723 (RNA binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0031625 (ubiquitin protein ligase binding), GO:1990381 (ubiquitin-specific protease binding), GO:0019903 (protein phosphatase binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0065008 (regulation of biological quality), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0061919 (process utilizing autophagic mechanism), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0012501 (programmed cell death), GO:0044085 (cellular component biogenesis), GO:0060548 (negative regulation of cell death), GO:0080134 (regulation of response to stress), GO:0044248 (cellular catabolic process), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032886 (regulation of microtubule-based process), GO:0044089 (positive regulation of cellular component biogenesis), GO:0006914 (autophagy), GO:0044087 (regulation of cellular component biogenesis), GO:0009894 (regulation of catabolic process), GO:0051726 (regulation of cell cycle), GO:0046907 (intracellular transport), GO:0042391 (regulation of membrane potential), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0035966 (response to topologically incorrect protein), GO:0016043 (cellular component organization), GO:1901575 (organic substance catabolic process), GO:0051128 (regulation of cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0010564 (regulation of cell cycle process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010648 (negative regulation of cell communication), GO:1901564 (organonitrogen compound metabolic process), GO:1903047 (mitotic cell cycle process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0035556 (intracellular signal transduction), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0051649 (establishment of localization in cell), GO:0051130 (positive regulation of cellular component organization), GO:0031647 (regulation of protein stability), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0007059 (chromosome segregation), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0000278 (mitotic cell cycle), GO:0009896 (positive regulation of catabolic process), GO:0043254 (regulation of protein-containing complex assembly), GO:0071705 (nitrogen compound transport), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0030163 (protein catabolic process), GO:0071702 (organic substance transport), GO:0007093 (mitotic cell cycle checkpoint signaling), GO:0072331 (signal transduction by p53 class mediator), GO:1905897 (regulation of response to endoplasmic reticulum stress), GO:0022607 (cellular component assembly), GO:0009057 (macromolecule catabolic process), GO:0006886 (intracellular protein transport), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:0044265 (cellular macromolecule catabolic process), GO:0015031 (protein transport), GO:0043933 (protein-containing complex organization), GO:0022411 (cellular component disassembly), GO:0061024 (membrane organization), GO:0032386 (regulation of intracellular transport), GO:0006839 (mitochondrial transport), GO:1901215 (negative regulation of neuron death), GO:0098813 (nuclear chromosome segregation), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0042176 (regulation of protein catabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0071310 (cellular response to organic substance), GO:0010256 (endomembrane system organization), GO:0072594 (establishment of protein localization to organelle), GO:0006796 (phosphate-containing compound metabolic process), GO:0030111 (regulation of Wnt signaling pathway), GO:0032880 (regulation of protein localization), GO:0030177 (positive regulation of Wnt signaling pathway), GO:1902115 (regulation of organelle assembly), GO:0016236 (macroautophagy), GO:0034976 (response to endoplasmic reticulum stress), GO:0035967 (cellular response to topologically incorrect protein), GO:0044265 (cellular macromolecule catabolic process), GO:0006915 (apoptotic process), GO:0051247 (positive regulation of protein metabolic process), GO:0033043 (regulation of organelle organization), GO:0045732 (positive regulation of protein catabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:0006986 (response to unfolded protein), GO:0008104 (protein localization), GO:0031329 (regulation of cellular catabolic process), GO:0006996 (organelle organization), GO:0007034 (vacuolar transport), GO:0010638 (positive regulation of organelle organization), GO:0031334 (positive regulation of protein-containing complex assembly), GO:0072657 (protein localization to membrane), GO:0042981 (regulation of apoptotic process), GO:0030162 (regulation of proteolysis), GO:0010821 (regulation of mitochondrion organization), GO:0071218 (cellular response to misfolded protein), GO:1905634 (regulation of protein localization to chromatin), GO:0016050 (vesicle organization), GO:0052547 (regulation of peptidase activity), GO:0010822 (positive regulation of mitochondrion organization), GO:0008637 (apoptotic mitochondrial changes), GO:0034620 (cellular response to unfolded protein), GO:0043523 (regulation of neuron apoptotic process), GO:0008333 (endosome to lysosome transport), GO:0007029 (endoplasmic reticulum organization), GO:0043524 (negative regulation of neuron apoptotic process), GO:0000819 (sister chromatid segregation), GO:0009411 (response to UV), GO:0090090 (negative regulation of canonical Wnt signaling pathway), GO:0061025 (membrane fusion), GO:0031401 (positive regulation of protein modification process), GO:0010498 (proteasomal protein catabolic process), GO:0043525 (positive regulation of neuron apoptotic process), GO:0070925 (organelle assembly), GO:0033365 (protein localization to organelle), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:1905037 (autophagosome organization), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0051276 (chromosome organization), GO:0051603 (proteolysis involved in protein catabolic process), GO:0097352 (autophagosome maturation), GO:0007033 (vacuole organization), GO:0045862 (positive regulation of proteolysis), GO:1901800 (positive regulation of proteasomal protein catabolic process), GO:2000060 (positive regulation of ubiquitin-dependent protein catabolic process), GO:0032984 (protein-containing complex disassembly), GO:0061136 (regulation of proteasomal protein catabolic process), GO:0007165 (signal transduction), GO:0043632 (modification-dependent macromolecule catabolic process), GO:1903322 (positive regulation of protein modification by small protein conjugation or removal), GO:0019941 (modification-dependent protein catabolic process), GO:0072665 (protein localization to vacuole), GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0042325 (regulation of phosphorylation), GO:0070585 (protein localization to mitochondrion), GO:1903052 (positive regulation of proteolysis involved in protein catabolic process), GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:0070972 (protein localization to endoplasmic reticulum), GO:1903052 (positive regulation of proteolysis involved in protein catabolic process), GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:0070972 (protein localization to endoplasmic reticulum), GO:0006511 (ubiquitin-dependent protein catabolic process), GO:0043067 (regulation of programmed cell death), GO:0031398 (positive regulation of protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005654 (nucleoplasm), GO:0005794 (Golgi apparatus), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)