Protein: Mitogen-activated protein kinase kinase kinase 14 (A6HJQ8)
Organism: Rattus norvegicus (Rat)
Function: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity
Subcellular location: Cytoplasm
InterPro domains:
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [513-525]
- IPR000719: Protein kinase domain (domain) [402-657]
- IPR017425: Mitogen-activated protein (MAP) kinase kinase kinase 14 (family) [1-942]
- IPR017441: Protein kinase, ATP binding site (binding_site) [408-432]
- IPR050538: Mitogen-activated protein kinase kinase kinase (family) [37-651]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [407-656]
- IPR042787: M3K14, catalytic domain (domain) [395-662]
Sequence:
MAVMEVACPGTPGSAVGQQKEFAKAKEKTQSPGKKQSCIFQLEAVEKSPVFCGKWEILNDVITKGTAKEGSEGGPPAISIIAQAECENSQEFSPTFSERIFIAGSQQYSQSESLDQIPNNVAHATEGKMARVCRKGKRHSKARKKRRKRRSKSLAQAGVALAKPLPRTPEQESCTIPVQEDESPLGNLYARNVSQFTKPLKGPGLGHLCFKKQDEGLRPVLPRPELHKLISPLQCLNHVWKLHHPQATGPLPHPTHPFPFSRMPHPFPFYPLEPWRPYTLNPAFLDKLAAVSGQRPLPGPPHLSKPAYRDSQKPLPGPHLESSCLSREALEKVPAEEYLVHALQGSVSSGQAHSLASLAKTWSSGSSKLQRFSPETEDNEGVLLTEKLKPVDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRAEELIACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQKGCLPEDRALYYLGQALEGLEYLHTHRVLHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPVREIPPSCTPLTAQAIQEGLRKEPIHRASAMELRRKVGKALQEVGGLKSPWKGEYKEPRPPPQDQAPCPQTLHTLPRENPPAKANTDGAPERQPPLPPEPPEPNKAPALNLSKEESGTWEPLPLSSLDPAPAKGPSLPDRRATFPELELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSLSLSEDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSSSCSMALARGRPTDIPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPATAFSLVTKDGQPVCYDMEVPDSGIDLQCTLAPDGSFAWAWRVKHGQLENRP
Predicted GO terms:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0006468 (protein phosphorylation), GO:0016310 (phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)