A potentially fatal symptom complex , sometimes referred to as Neuroleptic Malignant Syndrome ( NMS ) , has been reported in association with administration of antipsychotic drugs , including quetiapine . Rare cases of NMS have been reported with quetiapine . Clinical manifestations of NMS are hyperpyrexia , muscle rigidity , altered mental status , and evidence of autonomic instability ( irregular pulse or blood pressure , tachycardia , diaphoresis , and cardiac dysrhythmia ) . Additional signs may include elevated creatine phosphokinase , myoglobinuria ( rhabdomyolysis ) , and acute renal failure . The management of NMS should include immediate discontinuation of antipsychotic drugs .