These risks and uncertainties include , without limitation : general risks affecting the real estate industry ( including , without limitation , the inability to enter into or renew leases , dependence on tenants ' financial condition , and competition from other developers , owners and operators of real estate ) ; adverse economic or real estate developments in the life science industry or the company 's target markets ; risks associated with the availability and terms of financing , the use of debt to fund acquisitions and developments , and the ability to refinance indebtedness as it comes due ; failure to manage effectively the company 's growth and expansion into new markets , or to complete or integrate acquisitions and developments successfully ; risks and uncertainties affecting property development and construction ; risks associated with downturns in the national and local economies , increases in interest rates , and volatility in the securities markets ; potential liability for uninsured losses and environmental contamination ; risks associated with the company 's potential failure to qualify as a REIT under the Internal Revenue Code of 1986 , as amended , and possible adverse changes in tax and environmental laws ; and risks associated with the company 's dependence on key personnel whose continued service is not guaranteed .