Neal S. Young , MD , of the National Heart , Lung , and Blood Institute , National Institutes of Health , will discuss the pathophysiology of bone marrow failure and how clinical observations of patients with this disease have provided insights into the biology of autoimmunity , viral pathogenesis , and cancer at this year 's E. Donnall Thomas Lecture on Monday , December 8 , from 9 : 30 - 10 : 30 a.m.