Columns: District | Vacator | Reason for change | Successor | Date successor seated
Missouri 4th | George H. Christopher (D) | Died January 23, 1959 | William J. Randall (D) | March 3, 1959 | New York 43rd | Daniel A. Reed (R) | Died February 19, 1959 | Charles Goodell (R) | May 26, 1959 | Ohio 6th | James G. Polk (D) | Died April 28, 1959 | Ward Miller (R) | November 8, 1960 | Hawaii Territory At-large | John A. Burns (D) | Hawaii achieved statehood. | Seat eliminated August 21, 1959 | Seat eliminated August 21, 1959 | Hawaii At-large | New seat | Hawaii achieved statehood August 21, 1959 | Daniel Inouye (D) | August 21, 1959 | Illinois 12th | Charles A. Boyle (D) | Died November 4, 1959 | Vacant | Not filled this term | Iowa 4th | Steven V. Carter (D) | Died November 4, 1959 | John H. Kyl (R) | December 15, 1959 | Pennsylvania 17th | Alvin Bush (R) | Died November 5, 1959 | Herman T. Schneebeli (R) | April 26, 1960 | New York 23rd | Isidore Dollinger (D) | Resigned December 31, 1959 | Jacob H. Gilbert (D) | March 8, 1960 | Pennsylvania 18th | Richard M. Simpson (R) | Died January 7, 1960 | Douglas H. Elliott (R) | April 26, 1960 | North Carolina 12th | David M. Hall (D) | Died January 29, 1960 | Roy A. Taylor (D) | June 25, 1960 | Washington 3rd | Russell V. Mack (R) | Died March 28, 1960 | Julia Butler Hansen (D) | November 8, 1960 | Pennsylvania 18th | Douglas H. Elliott (R) | Died June 19, 1960 | J. Irving Whalley (R) | November 8, 1960 | North Dakota At-large | Quentin N. Burdick (D) | Resigned August 8, 1960 after becoming US Senator | Vacant | Not filled this term | Massachusetts 5th | Edith Nourse Rogers (R) | Died September 10, 1960 | Vacant | Not filled this term