Marine pharmacognosy
Compounds from Marine Sources in Clinical Level
Columns: Clinical Status | Compound Name | Trademark | Marine Organism α | Chemical Class | Molecular Target | Clinical Trials β | Disease Area
FDA-Approved | Cytarabine (Ara-C) | Cytosar-U ® | Sponge | Nucleoside | DNA Polymerase | >50/711 | Cancer | FDA-Approved | Vidarabine (Ara-A) | Vira-A ® | Sponge | Nucleoside | Viral DNA Polymerase | 0 | Antiviral | FDA-Approved | Ziconotide | Prialt ® | Cone Snail | Peptide | N-Type Ca 2+ Channel | 2/5 | Analgesic | FDA-Approved | Eribulin Mesylate (E7389) | Halaven ® | Sponge | Macrolide | s Microtubule | 19/27 | Cancer | FDA-Approved | Omega-3-Fatty Acid Ethyl Esters | Lovaza ® | Fish | Omega-3 Fatty Acids | Triglyceride -Synthesizing Enzymes | 45/94 | Hypertriglyceridemia | FDA-Approved | Trabectedin (ET-743) EU Approved only | Yondelis ® | Tunicate | Alkaloid | Minor Groove of DNA | 17/34 | Cancer | Phase III | Brentuximab Vedotin (SGN-35) | Adcetris ® | Mollusk | Antibody-Drug Conjugate (MM Auristatin E) | CD30 and Microtubules | 9/19 | Cancer | Phase III | Plitidepsin | Aplidin ® | Tunicate | Depsipeptide | Rac1 and JNK Activation | 1/7 | Cancer | Phase II | DMXBA (GTS-21) | N/A | Worm | Alkaloid | Alpha-7 Nicotinic Acetylcholine Receptor | 0/3 | Congnition , Schizophrenia | Phase II | Plinabulin (NPI 2358) | N/A | Fungus | Diketopiperazine | Microtubules and JNK Stress Protein | 1/2 | Cancer | Phase II | Elisidepsin | Irvalec ® | Mollusk | Depsipeptide | Plasma Membrane Fluidity | 1/2 | Cancer | Phase II | PM00104 | Zalypsis ® | Nudibranch | Alkaloid | DNA-Binding | 2/3 | Cancer | Phase II | Glembatumumab Vedotin (CDX-011) | N/A | Mollusk | Antibody Drug Conjugate (MM Auristatin E) | Glycoprotein NMB and Microtubules | 1/3 | Cancer | Phase I | Marizomib (Salinosporamide A) | N/A | Bacterium | Beta-Lactone-Gamma Lactam | 20S Proteasome | 4/4 | Cancer | Phase I | PM01183 | N/A | Tunicate | Alkaloid | Minor Groove of DNA | N/A | Cancer | Phase I | SGN-75 | N/A | Mollusk | Antibody Drug Conjugate (MM Auristatin F) | CD70 and Microtubules | 2/2 | Cancer | Phase I | ASG-5ME | N/A | Mollusk | Antibody Drug Conjugate (MM auristatin E) | ASG-5 and Microtubules | 2/2 | Cancer | Phase I | Hemiasterlin (E7974) | N/A | Sponge | Tripeptide | Microtubules | 0/3 | Cancer | Phase I | Bryostatin 1 | N/A | Bryozoa | Polyketide | Protein Kinase C | 0/38 | Cancer, Alzheimers | Phase I | s Pseudopterosin | N/A | Soft Coral | Diterpene Glycoside | Eicosanoid Metabolism | N/A | Wound Healing