Columns: District | Vacator | Reason for change | Successor | Date successor seated
Pennsylvania 4th | John A. Hanna (DR) | Died July 23, 1805 | Robert Whitehill (DR) | Seated November 7, 1805 | Georgia At-large | Cowles Mead (DR) | Lost contested election December 24, 1805 | Thomas Spalding (DR) | Seated December 24, 1805 | Georgia At-large | Joseph Bryan (DR) | Resigned sometime in 1806 | Dennis Smelt (DR) | September 1, 1806 | Georgia At-large | Thomas Spalding (DR) | Resigned sometime in 1806 | William W. Bibb (DR) | Seated January 26, 1807 | Pennsylvania 1st | Michael Leib (DR) | Resigned February 14, 1806 | John Porter (DR) | Seated December 8, 1806 | Maryland 7th | Joseph H. Nicholson (DR) | Resigned March 1, 1806 | Edward Lloyd (DR) | Seated December 3, 1806 | Virginia 13th | Christopher H. Clark (DR) | Resigned July 1, 1806 | William A. Burwell (DR) | December 1, 1806 | Connecticut At-large | John Cotton Smith (F) | Resigned sometime in August, 1806 | Theodore Dwight (F) | December 1, 1806 | Pennsylvania 3rd | Christian Lower (DR) | Resigned December 19, 1806 | Vacant | Not filled for remainder of term