Columns: District | Vacator | Reason for change | Successor | Date successor seated
North Carolina 7th | John Culpepper (F) | Seat declared vacant January 2, 1808 | John Culpepper (F) | Seated February 23, 1808 | New Jersey At-large | Ezra Darby (DR) | Died January 27, 1808 | Adam Boyd (DR) | Seated March 8, 1808 | Indiana Territory At-large | Benjamin Parke | Resigned March 1, 1808 | Jesse B. Thomas | October 22, 1808 | Pennsylvania 1st | Joseph Clay (DR) | Resigned March 28, 1808 | Benjamin Say (DR) | Seated November 16, 1808 | Massachusetts 2nd | Jacob Crowninshield (DR) | Died April 15, 1808 | Joseph Story (DR) | Seated May 23, 1808 | Rhode Island At-large | Nehemiah Knight (DR) | Died June 13, 1808 | Richard Jackson, Jr. (F) | Seated November 11, 1808