Question: What is the location of the enzyme Uroporphyrinogen III synthase?
SQL: SELECT "Location" FROM "2-182499-1" WHERE "Enzyme" = 'Uroporphyrinogen III synthase';

Question: What is Protoporphyrin IX's substrate?
SQL: SELECT "Substrate" FROM "2-182499-1" WHERE "Product" = 'Protoporphyrin IX';

Question: Which substrate has an OMIM of 176000?
SQL: SELECT "Substrate" FROM "2-182499-1" WHERE "OMIM" = 176000.0;