Question: When is the latest game the bills had 21 first downs
SQL: SELECT MIN("Game") FROM "1-16028459-2" WHERE "Bills first downs" = 21.0;

Question: How many first downs did the bills have when their opponent had 6
SQL: SELECT MIN("Bills first downs") FROM "1-16028459-2" WHERE "Opponents" = 6.0;

Question: How many points did the bills score when their opponent had 14
SQL: SELECT "Bills points" FROM "1-16028459-2" WHERE "Opponents" = 14.0;

Question: What is the minimum number of points given up to the Baltimore Colts
SQL: SELECT MIN("Opponents") FROM "1-16028459-2" WHERE "Opponent" = 'Baltimore Colts';