Effects of Different Types of Anaesthesia on Intraocular Pressure During Lumbar Disc Herniation Surgery

Study Overview
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Brief Summary
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The aim of this study was to investigate the effects of anaesthesia methods on intraocular pressure during lumbar disc surgery performed in the prone position.

Detailed Description
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The study included 75 patients with lumbar disc herniation between the ages of 18-75, with the American Society of Anesthesiologists (ASA) 1-2. The patients were randomly divided into 3 groups: propofol, desflurane, spinal. Intraocular pressure (IOP) was measured at 5 time points throughout surgery, including baseline (T1), 10 minutes after anesthesia (T2), 10 minutes after prone positioning (T3: early prone), 30 minutes after prone positioning (T4: late prone), and 10 minutes after returning to the supine position (T5). Hemodynamic parameters were measured at these time points. Hemoglobin and hematocrit values were measured preoperatively and on the first postoperative day.

Official Title
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Effects of Propofol, Desflurane and Spinal Anesthesia on Intraocular Pressure During Lumbar Disc Herniation Surgery: A Randomized Controlled Study

Conditions
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Anesthesia, Disk Herniated Lumbar, Intraocular Pressure

Intervention / Treatment
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* Other: Spinal Anesthesia Group
* Other: Desflurane Group
* Other: Propofol Group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA 1-2 according to the American Society of Anesthesiologists (ASA) Classification. Exclusion Criteria: Who did not sign the informed consent form, patients who required emergency surgery, eye surgery recipients, subjects with acute or chronic eye diseases other than refractive errors, individuals detected to have elevated IOP in preoperative measurements

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: The study included 75 patients with lumbar disc herniation between the ages of 18-75, with the American Society of Anesthesiologists (ASA) 1-2. The patients were randomly divided into 3 groups: propofol, desflurane, spinal. Intraocular pressure was measured at 5 time points throughout surgery, including baseline (T1), 10 minutes after anesthesia (T2), 10 minutes after prone positioning (T3: early prone), 30 minutes after prone positioning (T4: late prone), and 10 minutes after returning to the supine position (T5). Hemodynamic parameters were measured at these time points. Hemoglobin and hematocrit values were measured preoperatively and on the first postoperative day.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Spinal Anesthesia Group<br>Intraocular pressure values of the patients operated with spinal anaesthesia were measured | Other: Spinal Anesthesia Group<br>* Effect of spinal anesthesia on intraocular pressure<br>|
| Active Comparator: Desflurane Group<br>Intraocular pressure values were measured in patients operated under general anaesthesia with desflurane. | Other: Desflurane Group<br>* Effect of general anesthesia with desflurane on intraocular pressure<br>|
| Active Comparator: Propofol Group<br>Intraocular pressure values were measured in patients operated under general anaesthesia with desflurane. | Other: Propofol Group<br>* Effect of general anesthesia with propofol on intraocular pressure<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| intraocular pressure | Intraocular pressure was measured a total of 5 times at set time points throughout the procedures. | Time 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supine | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean Arterial Pressure | Mean Arterial Pressure was measured a total of 5 times at set time points throughout the procedures. | Time 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supine | 
| Heart Rate | Heart Rate was measured a total of 5 times at set time points throughout the procedures. | Time 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supine | 
| End Tidal Carbon Dioxide (CO2) | End Tidal CO2 was measured a total of 5 times at set time points throughout the procedures. | Time 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supine | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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prone position, intraocular pressure, hemodynamics, anesthesia,spinal, anesthesia,general