Sclerotherapy and Bone Marrow Injection In Aneurysmal Bone Cyst

Study Overview
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Brief Summary
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Aneurysmal bone cysts (ABCs) are benign, locally destructive growing bone tumors, which were first described in 1942 by Jaffé and Lichtenstein (1). They are most often diagnosed in childhood and early adulthood. The literature reports that ABCs comprise 1-6% of all primary benign bone tumors (2). Most cases of ABCs (75-90%) are reported for patients younger than 20 years, with a slightly higher incidence for females (3). Most common localizations are the pelvis, the metaphysis of long bones and the spine, but ABCs can also affect any other localization(2). ABCs that are associated with a preexisting osseous lesion are defined as secondary ABCs. They represent approximately 30% of all ABCs (2). Secondary ABCs can occur, e.g., in cases of a giant cell tumor, chondroblastoma or telangiectatic osteosarcoma

Detailed Description
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The clinical symptoms of an ABC are usually accidently discovered or may consist of pain and swelling in the affected region and pathological fractures ( complete and incomplete ) can be observed occasionally. In conventional radiography a relatively well-defined osteolytic, expansile lesion with possible blowout of the periosteum and a soap-bubble appearance can be found (4). MRI scanning shows cystic formations with typical fluid-fluid levels due to blood sedimentation (7). Because of the possible rapid growth with local destruction, the literature describes cases of ABCs that mimic malignant bone tumors

Official Title
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Sclerotherapy With Adjuvant Bone Marrow Injection In Management of Aneurysmal Bone Cyst

Conditions
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Orthopedic Disorder

Intervention / Treatment
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* Procedure: Sclerotherapy With Adjuvant Bone Marrow Injection In Management of Aneurysmal Bone Cyst


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All Patients above age of 1 year. The affected area was all bones except skull, ribs, and other non-orthopedic specialties. Primary or recurrent ABC Incomplete Fractured affected bones as greenstick fracture. Healed Pathological fracture without any surgical intervention Exclusion Criteria: ABC. In skull, ribs, and other non-orthopedic specialties. Age less than 1 year Suspected malignancy or other bone cysts Complete fractured bones and healed pathological fracture with surgical intervention.

Ages Eligible for Study
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Minimum Age: 1 Year

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| sclerotherapy and bone marrow<br>Sclerotherapy With Adjuvant Bone Marrow Injection In Management of Aneurysmal Bone Cyst | Procedure: Sclerotherapy With Adjuvant Bone Marrow Injection In Management of Aneurysmal Bone Cyst<br>* Sclerotherapy With Adjuvant Bone Marrow Injection In Management of Aneurysmal Bone Cyst<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Healing | Results will discuss in this study, according to assessment of ABC healing ( complete or not ) , and also following assessment of recurrence rate and incidence of complication. | 1 year |