Is There an Association Between Quadriceps Strength and Different Markers of Fragility in Patients With Cirrhosis?

Study Overview
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Brief Summary
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Physical frailty and malnutrition are important factors in morbidity and mortality in patients with cirrhosis. No study has assessed the validity of Liver Frailty Index (LFI) against reference measures such as maximal lower limb strength. Main objective: To assess the association between LFI score and isometric maximal lower limb strength (quadriceps) in patients with cirrhosis.

Official Title
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Is There an Association Between Quadriceps Strength and Different Markers of Fragility in Patients With Cirrhosis?

Conditions
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Cirrhosis

Intervention / Treatment
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* Other: Frailty assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: SUBJECT : with a diagnosis of liver cirrhosis (regardless of cirrhosis stage and etiology) under the care of a physician practising in the University Hospital Estaing in Clermont-Ferrand affiliated to the french social security system Exclusion Criteria: SUBJECT: with hepatocellular carcinoma with HIV infection with hepatic encephalopathy grade ≥ 2 with cognitive dysfunction with contraindication for physical activity with knee pain/knee disorders pregnant or breastfeeding under protective supervision (guardianship, curatorship, protection of the court)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: single group assignment<br>Same assessments for all patients. | Other: Frailty assessment<br>* Assessments for all patients : isometric quadriceps strength, malnutrition by RFH-NPT and MNA questionnaires, body composition by circumference and triceps skinfold, frailty by LFI and SPPB, muscle cramps by Cramp questionnaire.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Isometric quadriceps strength | Isometric quadriceps strength (N.m) will be assessed 3 times with 30 second rest between each try. The dominant leg of each participant will be assessed, a standardised warm-up will be conducted to have effective results. | once, at inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Malnutrition: Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) |  | once, at inclusion | 
| Malnutrition: Mini Nutritional Assessment (MNA)) |  | once, at inclusion | 
| Body composition by circumference and triceps skinfold |  | once, at inclusion | 
| Frailty by LFI |  | once, at inclusion | 
| Frailty by Short Physical Performance Battery (SPPB) |  | once, at inclusion | 
| Muscle cramps by Cramp questionnaire |  | once, at inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Frailty markers, Quadriceps strength