Effect of Physical Rehabilitation in Patients With Parkinson's Disease

Study Overview
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Brief Summary
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This is a prospective study. The aim of this study is to investigate the effect of exercise retraining on cardiorespiratory parameters, postural balance, sociopsychological variables, and cognitive function in subjects with Parkinson's disease. There will be two measurement sessions, one pre-intervention and one post-intervention (measuring cardiorespiratory parameters, evaluating dynamic and static postural balance, and assessing cognitive function).

Detailed Description
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this is a 12-week prospective study with the theme that I wish to develop in this context entitled the effect of exercise retraining on cardiorespiratory parameters, postural balance, sociopsychological variables, and cognitive function in subjects with Parkinson's disease. There will be two measurement sessions, one pre-intervention and one post-intervention (measuring cardiorespiratory parameters, evaluating dynamic and static postural balance, and assessing cognitive function). The recruited subjects will be randomly assigned to two groups: a control group and an experimental group. The subjects will be invited to attend the program three times per week. The control group will engage in an endurance training program, while the experimental group will participate in a combined endurance training and cognitive training program

Official Title
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Effect of Physical Rehabilitation on Cardiorespiratory Parameters, Postural Balance and Sociopsychological and Cognitive Variables in Patients With Parkinson's Disease

Conditions
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Parkinson Disease

Intervention / Treatment
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* Other: rehabilitation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed with Parkinson's disease according to the Movement Disorder Society (MDS) 2015 criteria. Mild to moderate stage according to the Hoehn and Yahr scale. No hearing or visual impairments that could hinder the integration and implementation of the rehabilitation protocol. Has the ability to communicate and walk. Patient has been stable on treatment for 3 months. Exclusion Criteria: A contraindication to engaging in cardiovascular physical activity A Montreal Cognitive Assessment score (MoCA ) of less than 24. A current psychiatric disorder that could make it difficult or dangerous to adhere to the research protocol. Musculoskeletal impairments or excessive pain in any joint that could limit participation in an exercise program. Treatment with sedative medications
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: control group<br>The control group will be invited to attend the program three times per week and will engage in an endurance training program | Other: rehabilitation<br>* The subjects will be invited to attend the program three times per week.<br>|
| Experimental: experimental group<br>the experimental group will be invited to attend the program three times per week and will participate in a combined endurance training and cognitive training program. | Other: rehabilitation<br>* The subjects will be invited to attend the program three times per week.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiorespiratory Parameters | Cardiorespiratory Parameters will be assessed using the six-minute walk test (6MWT). | There will be two measurement sessions, one pre-intervention and one post-intervention (After 12 week for each patient) | 
| Postural Balance | Postural balance will be assessed using the Timed Up and Go test (TUG) and stabilometry platform | There will be two measurement sessions, one pre-intervention and one post-intervention (After 12 week for each patient) | 
| Depression | The depression variable will be assessed through Beck Depression Inventory-II . | There will be two measurement sessions, one pre-intervention and one post-intervention (After 12 week for each patient) | 
| Cognitive Function | Cognitive function will be evaluated using the Montreal Cognitive Assessment score (MoCA) . | There will be two measurement sessions, one pre-intervention and one post-intervention (After 12 week for each patient) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Strength | handgrip test, Functional Reach Test, Five time to sit and stand test | There will be two measurement sessions, one pre-intervention and one post-intervention (After 12 week for each patient) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Parkinson Disease, cognitive function, postural balance, physical rehabilitation