Evaluation of Skeletal Muscle Function Using Ultrasonic Elastography

Study Overview
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Brief Summary
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The goal of observational study is to evaluation of skeletal muscle function in patients with chronic obstructive pulmonary disease before and after lung rehabilitation training using ultrasonic elastography in Chronic Obstructive Pulmonary Disease. The main question it aims to answer are:Evaluation of skeletal muscle function in patients with chronic obstructive pulmonary disease before and after lung rehabilitation training using ultrasonic elastography. Participants will undergo pulmonary rehabilitation.

Official Title
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Evaluation of Skeletal Muscle Function in Patients With Chronic Obstructive Pulmonary Disease Before and After Lung Rehabilitation Training Using Ultrasonic Elastography

Conditions
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Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Other: pulmonary rehabilitation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The age is between 40-80 years old Patients with chronic obstructive pulmonary disease who meet the diagnostic criteria of GOLD guideline(2019) There was no acute exacerbation in the past 12 weeks Exclusion Criteria: Hypoxemia (oxygen partial pressure is less than 60mmHg or oxygen saturation is less than 88% at rest), or patients who need continuous oxygen inhalation, or patients with any contraindication to exercise test (refer to the American Thoracic Association/American Association of Thoracic Physicians exercise test guidelines) Oral glucocorticoids Receive long-term oxygen therapy prescription Have participated in supervised exercise programs in the past 12 months History of other lung diseases, including pneumoconiosis, bronchiectasis, tuberculosis, primary pulmonary hypertension, pulmonary embolism, interstitial lung disease Diseases that restrict the active exercise ability of participants or involve skeletal, neuromuscular, cardiovascular or metabolic disorders of muscle activity, such as tumors, diabetes, muscle weakness, etc

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| pulmonary rehabilitation<br> | Other: pulmonary rehabilitation<br>* The participants would undergo pulmonary rehabilitation.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effectiveness of pulmonary rehabilitation training | 6-minute walking distance (6MWD) | baseline | 
| Effectiveness of pulmonary rehabilitation training | 6-minute walking distance (6MWD) | 1 week after pulmonary rehabilitation | 
| Effectiveness of pulmonary rehabilitation training | COPD Assessment Test (CAT) score | baseline | 
| Effectiveness of pulmonary rehabilitation training | COPD Assessment Test (CAT) score | 1 week after pulmonary rehabilitation | 
| Effectiveness of pulmonary rehabilitation training | St. George's Respiratory Questionnaire (SGRQ) | baseline | 
| Effectiveness of pulmonary rehabilitation training | St. George's Respiratory Questionnaire (SGRQ) | 1 week after pulmonary rehabilitation | 
| Effectiveness of pulmonary rehabilitation training | modified Medical Research Council (mMRC) dyspnea scores | baseline | 
| Effectiveness of pulmonary rehabilitation training | modified Medical Research Council (mMRC) dyspnea scores | 1 week after pulmonary rehabilitation | 
| Effectiveness of pulmonary rehabilitation training | rectus femoris muscle strength via a dynamometer | baseline | 
| Effectiveness of pulmonary rehabilitation training | rectus femoris muscle strength via a dynamometer | 1 week after pulmonary rehabilitation | 
| Effectiveness of pulmonary rehabilitation training | 6-30-second sit-to-stand test | baseline | 
| Effectiveness of pulmonary rehabilitation training | 6-30-second sit-to-stand test | 1 week after pulmonary rehabilitation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Forced Expiratory Volume in 1-second(FEV1) | Pulmonary function test | before pulmonary rehabilitation | 
| Forced Expiratory Volume in 1-second(FEV1) | Pulmonary function test | 1 week after pulmonary rehabilitation | 
| Ultrasonic elastic imaging of rectus femoris | Ultrasonic elastography of skeletal muscle | before pulmonary rehabilitation | 
| Ultrasonic elastic imaging of rectus femoris | Ultrasonic elastography of skeletal muscle | 1 week after pulmonary rehabilitation |