Time Effect on the Predictability of Different Grafting for Gingival Recession RT 1

Study Overview
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Brief Summary
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The primary objective of this study was to evaluate time effect on the clinical predictability of collagen matrix Xenograft (CMX) with melatonin gel versus connective tissue graft (CTG) and determine whether it is proposed to be an alternative in multiple adjacent gingival recession (MAGR) in recession type one (RT1)

Detailed Description
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this study was conducted to evaluate time effect on the clinical predictability of collagen matrix Xenograft (CMX) with melatonin gel versus connective tissue graft (CTG) and determine whether it is proposed to be an alternative in multiple adjacent gingival recession

Official Title
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Time Effect on the Predictability of Different Grafting Materials in Treatment of Gingival Recession RT 1in the Esthetic Zone

Conditions
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Gingival Recession Types One(RT1)

Intervention / Treatment
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* Combination Product: melatonin with collagen matrix
* Combination Product: connective tissue graft (CTG)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Presence of RT1 GRs of the maxillary or mandibular arch in the esthetic zone with a GR depth ≥2 mm, patients >18 years old, Full mouth plaque index score <20% Systemically and periodontally healthy patients. Exclusion Criteria: Smokers Patients with periodontitis stage III and IV were previous surgical treatment of GR, Pregnant or breastfeeding women; P Patients with para-functional habits or any source of occlusal trauma.

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: collagen matrix<br>melatonin in collagen matrix with Modified Coronally Advanced Tunneling Technique (MCAT) | Combination Product: melatonin with collagen matrix<br>* (CMX) with melatonin in the esthetic zone using Modified Coronally Advanced Tunneling Technique (MCAT)<br>|
| Active Comparator: connective tissue graft (CTG)<br>connective tissue graft with Modified Coronally Advanced Tunneling Technique (MCAT) | Combination Product: connective tissue graft (CTG)<br>* control group connective tissue graft using Modified Coronally Advanced Tunneling Technique (MCAT)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| interproximal clinical attachment level | measured from CEJ to base of pocket depth by using periodontal prob | 6-9 months | 
| Probing pocket depth (PPD) | from gingival margin to pocket depth measured by mm | 6-9 months | 
| Recession depth | measure from CEJ to gingival margin by mm | 6-9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Keratinized tissue width | from free gingival groove to MGJ | 6-9 months |