The Impact of Fish Oil Supplementation on the Outcome of Children With Pneumonia i

Study Overview
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Brief Summary
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The aim of study is to investigate the effect of enteral feeding of Omega-3 on the outcome of children with Pneumonia in PICU

Detailed Description
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Group A(cases) will be supplemented by omega-3 fatty acids for immediate post admission consecutive 7 days besides conventional treatment of pneumonia, in a dose of 350 mg twice daily for children less than 3 years and 450 mg twice daily for older children according to the standard treatment per the American Institute of Medicine of the National Academies guidelines for maximum dose for this age group. (Institute of Medicine of the National Academies,2016) Side effects of omega-3 supplements are usually mild. They include unpleasant taste, bad breath, bad-smelling sweat, headache, and gastrointestinal symptoms such as heartburn, nausea, and diarrhea. (Office of Dietary Supplements ,2016) Group B(controls) will be received enteral feeding without omega-3 fatty acid support.

Official Title
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The Impact of Fish Oil Supplementation on the Outcome of Children With Pneumonia in the Intensive Care Unit

Conditions
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Pneumonia

Intervention / Treatment
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* Dietary Supplement: Fish oil (Omega)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria All children patients with severe pneumonia admitted to PICU Both sexes Age: under 5 years Whose parents or caregivers approve for participation in the study Exclusion Criteria Patients with chronic illnesses to exclude bias that could be emerged due to the chronic disease effect Whose parents or caregivers will not apply for participation in the study Patients who will be contraindicated for enteral feeding

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 5 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Randomized Controlled Trial
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Children with Pneumonia in intensive care unit receiving fish oil and the standard treatment<br> | Dietary Supplement: Fish oil (Omega)<br>* We will use a dietary supplement source of omega 3 fatty acids from the available syrup ( each 5 ml contain 640 mg of high DHA Fish oil) so we will give it in a dose 2.7 ml twice daily for children between 1 and 3 years and 3.5 ml twice daily for children between 4 and 5 years.<br>|
| No Intervention: Children with Pneumonia in intensive care unit receiving the standard treatment only<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hospital length stay | Hospital length stay will be measured between the two groups | Through study completion, an average of 1 yea |