Ibuprofen Versus Ketorolac For Postoperative Pain Relief After Cesarean Section

Study Overview
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Brief Summary
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The aim of this study will be to evaluate the effectiveness of intravenous ibuprofen versus intravenous ketorolac for postoperative pain relief after caesarian section The Primary outcome is measurement of visual analogue score during rest and movement The Secondary outcome is measurement of 24 hours opioids requirements.

Detailed Description
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METHODS 1. Preoperative assessment: All parturients included in the study will be assessed thoroughly by: Proper history taking Complete clinical examination. All needed laboratory investigations. 2. Patient preparation: On arrival to the operative theatre , an 18 G intravenous cannula will be inserted in a peripheral vein Steps of general anaesthesia will be explained to the parturients. Using a multichannel monitor (mindary) iMeC12 SHENZEN MINDRAY BIO-MEDICAL ELECTRONICS CO, LTD, CHINA, the parturients will be continuously monitored for: Non-invasive arterial blood pressure (NIBP) in (mmHg). Heart rate (beats/min). Oxygen saturation (percentage). End tidal carbon dioxide(mmhg). 3. Anaesthesia technique: Left uterine displacement will be maintained by a wedge under the right hip. Preoxygenation with 100% oxygen will be done for 3-5 minutes For both groups rapid sequence induction will be done with 2mg/kg propofol and 0.9 mg/kg rocuronium,50 microgram fentanyl followed by tracheal intubation and IPPV volume control. Anaesthesia will be maintained with 1.2% isoflurane in 100% Oxygen and 0.1 mg /kg roccuronium will be administrated if needed. After delivery oxytocin infusion 10 IU will be given After finishing operation , inhalational anaesthesia will be stopped and all parturients will receive 2mg/kg sugammadex when train of four is 75%. Then all parturients will be discharged to ward to be put under observation for 24 hours and they will receive NSAID immediately on arrival to the ward . Group A parturients will receive 30 mg ketorolac in 200 cc normal saline intravenously every 6 hours Group B parturients will receive 800 mg Ibuprofen in 200 cc normal saline intravenously every 6 hours All Parturients will receive 25 mg pethidine if visual analogue score (VAS) ≥4. MEASUREMENTS The following parameters will be measured for all parturients, in both groups: Demographic data: Age (years) Body Mass index ( kilogram/meters2) Weight (kilograms) Height (meters) Duration of surgery (minutes) Postoperative hemodynamics: Heart rate (beats/min) Blood pressure (mmHg) Baseline value immediately after extubation before giving any analgesia. Immediately and 2, 4, 6, 12, 24 hours after end of surgery. Visual analogue score: All parturients will be trained to use VAS. VAS at rest (VASR) and during movement (VASM) will be measured at 1,3,6,12,18,24 hours following surgery .The VAS score will be presented as 10 cm horizontal line anchored by the words no pain(corresponding to zero) and worst pain possible(corresponding to ten).The values will be scored as mild pain(from 1 to 3) ,moderate pain (from 4 to 6) and severe pain (from 7 to 10). If VAS is ≥4 parturients will receive 25mg pethidine iv. Opioid requirement During the first 24 hours after surgery(mg) The doses of pethidine required during the first 24 hours postoperatively will be calculated. Nocturnal awakening due to pain (percentage) The percentage of parturients who become awake at night due to pain Time to ambulate (minutes) The time the parturient takes to get out of bed and to do light activities such as sitting, standing or walking. Time to first analgesic dose (minutes) rescue analgesia The time when the patient require the first analgesic dose in the ward.

Official Title
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The Effectiveness Of Intravenous Ibuprofen Versus Intravenous Ketorolac For Postoperative Pain Relief After Cesarean Section

Conditions
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Pain, Postoperative

Intervention / Treatment
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* Drug: Ibuprofen 800 mg


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Parturients aged 20-30years. ASA physical satatus: II. Anticipated hospital stay for at least 24 hours. Refusal of spinal anaesthesia. Exclusion Criteria: Known allergy to the used drugs. Renal and hepatic impairement History of brochial asthma. Low platelets count (<70000). Bleeding diathesis and with history or risk of intracranial hemorrhage. Obese and morbidly obese parturients. GIT problems as gastritis or GI bleeding.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Group (A):<br>30mg ketorolac in 200cc normal saline intravenously every 6hours for 24hours postoperatively. | |
| Active Comparator: Group (B):<br>800mg ibuprofen in 200cc normal saline intravenously every 6 hours for 24hours postoperatively. | Drug: Ibuprofen 800 mg<br>* Intravenous Ibuprofen versus intravenous Ketorolac for postoperative pain relief<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| measurement of visual analogue score | measurement of visual analogue score during rest and movement . The Score range from 0- 10 . 0 means no pain and 10 indicates the worst pain ever | after the surgery average 24 hours postoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| opioids requirements. | Total opioid cumulative requirement dose | after the surgery average 24 hours postoperative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postoperative, pain relief, CESAREAN SECTION