Peppermint Inhalation Versus Swedish Massage on Chemotherapy Induced-Nausea and Vomiting in Children With Leukemia

Study Overview
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Brief Summary
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Clinical trials was used to compare the effect of peppermint inhalation and Swedish massage on chemotherapy induced-nausea and vomiting in children with leukemia. the main research hypotheses are: Children with leukemia who receive peppermint inhalation exhibit less chemotherapy induced- nausea and vomiting than those who don't receive. Children with leukemia who receive Swedish massage exhibit less chemotherapy induced-nausea and vomiting than those who don't receive. Children with leukemia who receive Swedish massage exhibit less chemotherapy induced- nausea and vomiting than those who receive peppermint inhalation. children divided into three groups of study ( control group, peppermint inhalation group and Swedish massage group) to identify its effect on chemotherapy induced nausea and vomiting.

Official Title
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Comparative Effect of Peppermint Inhalation and Swedish Massage on Chemotherapy Induced-Nausea and Vomiting in Children With Leukemia.

Conditions
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Leukemia

Intervention / Treatment
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* Behavioral: Peppermint Inhalation
* Behavioral: Swedish Massage


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Received first chemotherapy session Intact skin in the massage Exclusion Criteria: Chronic and acute disorders such as respiratory, cardiovascular diseases...etc. Allergy from any essential oils.

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 15 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control group<br>Children with leukemia received routine nursing and hospital care for management of chemotherapy induced nausea and vomiting (antiemetic medications only). | |
| Experimental: Peppermint Inhalation Group<br>Children with leukemia received the inhalation of essential oil of peppermint 2% in addition to routine nursing and hospital care for management of chemotherapy induced nausea and vomiting. | Behavioral: Peppermint Inhalation<br>* The researcher applied two drops (0,2ml) of 2% essential oil of peppermint on a piece of cotton. Then, each child was instructed to take three breaths of the essence that had been put on a piece of cotton before starting chemotherapy session with three minutes. In addition, the piece of cotton with peppermint essence was kept at bed side table to use by child as needed throughout the chemotherapy session. Inhalation of peppermint essence was applied for three consecutive chemotherapy sessions.<br>|
| Experimental: Swedish Massage Group:<br>Children with leukemia received the Swedish massage therapy in addition to routine nursing and hospital care for management of chemotherapy induced nausea and vomiting. | Behavioral: Swedish Massage<br>* Children were received Swedish massage therapy for twenty minutes prior to chemotherapy session in a private and special room with effleurage, petrissage, friction, and tapotement and vibration movements for three consecutive chemotherapy sessions. The researcher applied facilitating olive oil in hands and pre warmed before applying massage. The massage technique was applied in prone position with mild to moderate pressure with guidance by the child's feedback and tolerance by using non-scented olive oil. Children's privacy was considered.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Experience of anticipatory nausea | Yes/No | assessed immediately before chemotherapy administration for three consecutive chemotherapy sessions | 
| Worst of anticipatory nausea | No/Mild/Moderate/severe/intolerable | assessed immediately before chemotherapy administration for three consecutive chemotherapy sessions | 
| Duration of anticipatory nausea | /Minutes | assessed immediately before chemotherapy administration for three consecutive chemotherapy sessions | 
| Frequency of anticipatory nausea | once/twice/ three times and more | assessed immediately before chemotherapy administration for three consecutive chemotherapy sessions | 
| Experience of anticipatory vomiting | Yes/No | assessed immediately before chemotherapy administration for three consecutive chemotherapy sessions | 
| Worst of anticipatory vomiting | No/Mild/Moderate/severe/intolerable | assessed immediately before chemotherapy administration for three consecutive chemotherapy sessions | 
| Amount of anticipatory vomiting | Small/ Moderate/ Large | assessed immediately before chemotherapy administration for three consecutive chemotherapy sessions | 
| Frequency of anticipatory vomiting | once/ twice/ three times and more. | assessed immediately before chemotherapy administration for three consecutive chemotherapy sessions | 
| Experience of acute nausea . | Yes/no. | First 24 hours after first chemotherapy administration of study. Assessed within the first 24 hours after second chemotherapy administration of study. Assessed within the first 24 hours after third chemotherapy administration of study. | 
| Worst of acute nausea . | No/Mild/Moderate/severe/intolerable | First 24 hours after first chemotherapy administration of study. Assessed within the first 24 hours after second chemotherapy administration of study. Assessed within the first 24 hours after third chemotherapy administration of study. | 
| Duration of acute nausea . | /hours. | Frst 24 hours after first chemotherapy administration of study. Assessed within the first 24 hours after second chemotherapy administration of study. Assessed within the first 24 hours after third chemotherapy administration of study. | 
| Frequency of acute nausea . | once/ twice/ three times and more. | First 24 hours after first chemotherapy administration of study. Assessed within the first 24 hours after second chemotherapy administration of study. Assessed within the first 24 hours after third chemotherapy administration of study. | 
| Experience of acute vomiting. | Yes/No. | First 24 hours after first chemotherapy administration of study. Assessed within the first 24 hours after second chemotherapy administration of study. Assessed within the first 24 hours after third chemotherapy administration of study. | 
| Worst of acute vomiting. | No/Mild/Moderate/severe/intolerable | First 24 hours after first chemotherapy administration of study. Assessed within the first 24 hours after second chemotherapy administration of study. Assessed within the first 24 hours after third chemotherapy administration of study. | 
| Amount of acute vomiting. | Small/ Moderate/ large | First 24 hours after first chemotherapy administration of study. Assessed within the first 24 hours after second chemotherapy administration of study. Assessed within the first 24 hours after third chemotherapy administration of study. | 
| Frequency of acute vomiting. | once/ twice/ three times and more. | First 24 hours after first chemotherapy administration of study. Assessed within the first 24 hours after second chemotherapy administration of study. Assessed within the first 24 hours after third chemotherapy administration of study. | 
| Experience of delayed nausea. | Yes/ No. | On second and third days after first chemotherapy administration.On second and third days after second chemotherapy administration. On second and third days after third chemotherapy administration. | 
| Worst of delayed nausea. | No/Mild/Moderate/severe/intolerable | On second and third days after first chemotherapy administration.On second and third days after second chemotherapy administration. On second and third days after third chemotherapy administration. | 
| Duration of delayed nausea. | /hours. | On second and third days after first chemotherapy administration.On second and third days after second chemotherapy administration. On second and third days after third chemotherapy administration. | 
| Frequency of delayed nausea. | once/ twice/ three times and more. | On second and third days after first chemotherapy administration.On second and third days after second chemotherapy administration. On second and third days after third chemotherapy administration. | 
| Experience of delayed vomiting. | Yes/ No. | On second and third days after first chemotherapy administration.On second and third days after second chemotherapy administration. On second and third days after third chemotherapy administration. | 
| Worst of delayed vomiting. | No/Mild/Moderate/severe/intolerable | On second and third days after first chemotherapy administration.On second and third days after second chemotherapy administration. On second and third days after third chemotherapy administration. | 
| Amount of delayed vomiting. | Small/ Moderate/ large | On second and third days after first chemotherapy administration.On second and third days after second chemotherapy administration. On second and third days after third chemotherapy administration. | 
| Frequency of delayed vomiting. | once/ twice/ three times and more. | On second and third days after first chemotherapy administration.On second and third days after second chemotherapy administration. On second and third days after third chemotherapy administration. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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leukemia, Swedish Massage, Peppermint Inhalation, Nausea, Vomiting, Chemotherapy, Children