Food-specific IgG4-guided Elimination Diets Improve Allergy Symptoms in Children

Study Overview
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Brief Summary
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Allergic diseases in children are major public health concerns due to their widespread and rising prevalence. The most classic pathway to trigger allergy is type I allergy mediated by immunoglobulin E(IgE), but the role of immunoglobulin G4(IgG4) in allergic diseases is still worth exploring.we have collected the data of allergic patients aged 0-14 years for retrospective cross-sectional analysis to evaluate the positive rates of total IgE, HDM IgE, FS-IgE and FS-IgG4. Meanwhile, investigators screened out patients who were treated with FS-IgG4-guided elimination diets with/without probiotics for more than 3 months to clarify the role of FS-IgG4 in childhood allergic diseases by assessing the improvement of clinical symptoms before and after treatment.

Detailed Description
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Allergic diseases in children are major public health concerns due to their widespread and rising prevalence. And management of allergic diseases beyond medication, such as food management is also very important. The most classic pathway to trigger allergy is type I allergy mediated by immunoglobulin E(IgE), but the role of immunoglobulin G4(IgG4) in allergic diseases is still worth exploring.In present study, investigators have collected the data of allergic patients aged 0-14 years for retrospective cross-sectional analysis to evaluate the positive rates of total IgE, house dust mite (HDM) IgE, FS-IgE and FS-IgG4. Meanwhile, investigators screened out patients who were treated with FS-IgG4-guided diet elimination with/without probiotics for more than 3 months to clarify the role of FS-IgG4 in childhood allergic diseases by assessing the improvement of clinical symptoms before and after treatment. This retrospective study was conducted to clarify the clinical relevance of food-specific IgG4 in allergic diseases and the effect of dietary avoidance on clinical symptoms, thus making a breakthrough in the diagnosis and treatment of childhood allergies.

Official Title
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Food-specific IgG4-guided Elimination Diets Improve Allergy Symptoms in Children

Conditions
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Rhinitis, Allergic, Asthma, Allergic, Conjunctivitis, Allergic, Atopic Dermatitis, Chronic Urticaria

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of allergic rhinitis. Clinical diagnosis of asthma. Clinical diagnosis of conjunctivitis. Clinical diagnosis of urticaria. Clinical diagnosis of atopic dermatitis. Total IgE,FS-IgE, HDM-IgE and FS-IgG4 must be tested. Exclusion Criteria: · Autoimmune diseases.

Ages Eligible for Study
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Minimum Age: 8 Months
Maximum Age: 14 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Respiratory system group<br>the patients who diagnosed as rhinitis, asthma and conjunctivitis were assigned to the respiratory system group | |
| Skin system group<br>the patients who diagnosed as urticaria and atopic dermatitis were assigned to the skin system group | |
| Multiple systems group<br>the patients who diagnosed with a combination of symptoms from different systems were assigned to the multiple systems group | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Age of participants | Age of participants were evaluated in the respiratory, dermatological and multisystemic groups. | 2018.1-2020.12 | 
| Gender ratio of participants | Gender ratio of participants were evaluated in the respiratory, dermatological and multisystemic groups. | 2018.1-2020.12 | 
| birth mode of participants | Birth mode of participants were evaluated in the respiratory, dermatological and multisystemic groups. | 2018.1-2020.12 | 
| Family history of allergies of the participants | Family history of allergies of the participants were evaluated in the respiratory, dermatological and multisystemic groups. | 2018.1-2020.12 | 
| total IgE | The average level of total IgE in the respiratory, cutaneous, and multi-system groups was assessed. | 2018.1-2020.12 | 
| FS-IgE | The positive rates of FS-IgE in respiratory, cutaneous and multi-system groups were evaluated. | 2018.1-2020.12 | 
| HDM-IgE | The average level of HDM-IgE in the respiratory, cutaneous, and multi-system groups was assessed. | 2018.1-2020.12 | 
| FS-IgG4 | The positive rates of FS-IgG4 in respiratory, cutaneous and multi-system groups were evaluated. | 2018.1-2020.12 | 
| The difference of total-IgE and FS-IgG4 positive rates among the three groups | Chi-square test was used to compare total-IgE (+) FS-IgG4 (+), total-IgE (+) FS-IgG4 (-), total-IgE (-) FS-IgG4 (+) and total-IgE (-) FS-IgG4 (-) among the three groups. | 2018.1-2020.12 | 
| The difference of FS-IgE and FS-IgG4 positive rates among the three groups | Chi-square test was used to compare FS-IgE (+) FS-IgG4 (+), FS-IgE (+) FS-IgG4 (-), FS-IgE (-) FS-IgG4 (+) and FS-IgE (-) FS-IgG4 (-) among the three groups. | 2018.1-2020.12 | 
| Comparison of FS-IgG4 positive rates among the three groups | The differences of 10 food-specific IgG4 antibodies (including eggs, milk, cod, beef, chicken, wheat, prawns, crab, mushrooms) in respiratory, skin and multi-system groups were evaluated. | 2018.1-2020.12 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Immunoglobulin E, Immunoglobulin G, Elimination Diets, chlid