Arterial Spin Label Depicted Ischemic Stroke Cohort (ASLIS)

Study Overview
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Brief Summary
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Establish a clinical cohort of acute ischemic stroke patients and find the determinant of the prognosis.

Detailed Description
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Enrollment: screening the candidates based on the inclusion and exclusion criteria, and sign the informed consent. Baseline evaluation: evaluate baseline situation of enrolled candidates. Inpatient view: view and evaluate enrolled candidates respectively at day 1, 3, 7 and 14 after stroke, and record the results. Follow-up: view the candidates at 90 days and one year after stroke onset, and record the results. Data analysis: analyze the results.

Official Title
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Arterial Spin Label Depicted Ischemic Stroke Cohort (ASLIS)

Conditions
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Acute Ischemic Stroke

Intervention / Treatment
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* Other: routine therapy of acute ischemia stroke


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 30-90, no gender restrictions. Onset of disease ≤7 days. Meet either of the following two conditions: ① Transient ischemic attack (TIA) ② Ischemia stroke (IS) Note: Acute IS diagnosis criteria: sudden and persistent focal or widespread neurological dysfunction, excluding other non-vascular causes of brain dysfunction (such as brain infection, head injury, brain tumor, epilepsy, severe metabolic diseases, or degenerative neurological diseases), confirmed by image as new IS. TIA diagnosis criteria: sudden and reversible focal neurological or retinal ischemic deficit caused by a reversible ischemia, usually lasting less than 24 hours, with no evidence of new IS on imaging, and excluding other non-ischemic causes (such as brain infection, head injury, brain tumor, epilepsy, severe metabolic diseases, or degenerative neurological diseases). Signed informed consent Exclusion Criteria: Clear cause of ischemic stroke other than atrial fibrillation. Other ischemic strokes with a clear cause. Presence of non-vascular intracranial disease. Presence of severe systemic diseases. Pregnancy or lactation. Unable to tolerate or cooperate with MRI examination. Unable to comply with follow-up due to geographical or other reasons.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Acute ischemia stroke<br>Best medcine treatment. It including antiplatelet drugs, statins, hypotensive drugs, antidiabetics, neurotrophic drugs, butylphthalide, edaravone. | Other: routine therapy of acute ischemia stroke<br>* Routine therapy of acute ischemia stroke based on the guidelines, which generally includes two parts: evaluation and medicine treatment. Evaluation includes peripheral blood test, radiologic examination, electrophysiological examination, ultrasonic examination. Medicine treatment includes drug therapy and rehabilitation.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progressively deterioration in acute phase | Number of participants whose SNOB (Standardised nursing observations for stroke) score at 7 days post ischemia stroke ≤ 2 points compared to baseline, and/or NIHSS score at 7 days post ischemia stroke ≥ 2 points compared to baseline are identified as progressively deterioration in acute phase. | 7 days after ischemia stroke onset | 
| Bad prognosis of acute ischemia stroke | Number of participants whose mRS (Modified rankin scale) score at 90 days after ischemia > 2 are identified as bad prognosis. | 90 days after ischemia stroke onset | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrent vascular episode | Including transient ischemia attack, intracranial hemorrhage, ischemia stroke | 1 year | 
| Recurrent artery stenosis | Degree of artery stenosis at one year after stenting > 50% | one year after stenting | 
| Unhealthy status | Any dimension in EQ-5D-3L (the generic three-level EuroQol five-dimensional questionnaire) score ≥ 2 | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acute ischemia stroke, arterial spin labeling, evaluation