Prospective Recurrent Pregnancy Loss Registry

Study Overview
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Brief Summary
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The purpose of this Registry is to prospectively collect data of Recurrent Pregnancy Loss (RPL) patients attending the specialized care centre at the BC Women's Hospital, in order to evaluate investigation practices, treatment options, and outcomes for this patient population over time.

Detailed Description
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The Recurrent Pregnancy Loss Program at the BC Women's Centre for Reproductive Health is the only tertiary care centre of its kind in British Columbia, and has provided specialized and comprehensive care to RPL patients for the past 15 years. Using a team-based collaborative model, the program provides point-of-care investigations, surgical treatment, clinical management, education, and grief counselling. All RPL patients are asked to complete the intake questionnaire prior to their initial visit at the clinic. If the patient provides their consent to take part in research, their data will be copied from the clinical database to the research database. The questionnaire includes information regarding patient demographics, obstetric history, gynecological history, personal and medical history, family history and partner information. Additionally, data will also be collected from patient charts, follow-up questionnaires sent once a year for the next 5 years following the patient's initial visit, and medical records from fertility clinics and general practitioners when available. The online data registry is housed in the Research Electronic Data Capture (REDCap) platform located at BC Children's Hospital (BCCH). As an optional component of this study, patients invited to join the registry will also be presented with the option to register with the BCCH BioBank to store their tissue samples collected in the RPL clinic for clinical & diagnostic purposes.

Official Title
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Prospective Recurrent Pregnancy Loss (ProRPL) Registry

Conditions
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Recurrent Pregnancy Loss

Intervention / Treatment
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* Other: Data Registry


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • All new and re-referred patients at the BC Women's Recurrent Pregnancy Loss Clinic with recurrent pregnancy loss, defined as ≥2 miscarriages or ≥1 miscarriage beyond 10 weeks gestation; therapeutic abortions, ectopic pregnancies, and molar pregnancies are excluded from the miscarriage count. Exclusion Criteria: • Patients at BC Women's Recurrent Pregnancy Loss Clinic seen for reasons other than recurrent pregnancy loss.

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 49 Years

Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Data Registry|Follow-up questionnaires sent every year for the 5 years following the patient's initial visit.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Live Birth | Percent of patients with a live birth within 5 years after initial visit at the clinic. | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Recurrent pregnancy loss, Unexplained, Explained, Miscarriage, Live Birth