Mobilization With Movement on Pain, Function, and Quality of Life in Patients With Thoracic Outlet Syndrome

Study Overview
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Brief Summary
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This randomized controlled trial aims to evaluate the effects of Mobilization with Movement (MWM) on pain, function, and quality of life in patients with Thoracic Outlet Syndrome (TOS) compared to conventional physiotherapy.

Official Title
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The Impact of Mobilization With Movement on Pain, Function, and Quality of Life in Patients With Thoracic Outlet Syndrome: A Randomized Controlled Trial

Conditions
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Thoracic Outlet Syndrome

Intervention / Treatment
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* Other: Mobilization with Movement (MWM) and Tailored Therapeutic Exercise Program
* Other: Conventional Physiotherapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults aged 18-65 years, diagnosed with TOS by a specialist, and experiencing symptoms for at least 3 months Exclusion Criteria: Previous surgery for TOS contraindications to manual therapy other comorbidities significantly affecting upper limb function

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Two-arm randomized controlled trial with an equal allocation ratio (1:1) for the experimental and control groups
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group A (experimental group)<br>MWM techniques combined with a tailored therapeutic exercise program | Other: Mobilization with Movement (MWM) and Tailored Therapeutic Exercise Program<br>* The intervention consists of MWM techniques targeting the cervical and thoracic spine, and the first rib, applied by a certified physiotherapist for 8 weeks, 2 sessions per week, each session lasting 45 minutes. The intervention also includes a tailored therapeutic exercise program for the patients, comprising postural correction, stretching, and strengthening exercises. This intervention will be compared to conventional physiotherapy in the control group.<br>|
| Active Comparator: Group B (control group)<br>Conventional physiotherapy combined with a tailored therapeutic exercise program | Other: Conventional Physiotherapy<br>* Conventional physiotherapy, including manual therapy (soft tissue mobilization, joint mobilization, and nerve gliding techniques) for 8 weeks, 2 sessions per week, each session lasting 45 minutes, combined with a tailored therapeutic exercise program (including postural correction, stretching, and strengthening exercises).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in Pain Intensity | Pain intensity will be assessed using the Numeric Pain Rating Scale (NPRS). | Changes in Pain intensity at Baseline, 4 weeks, 8 weeks, and 12 weeks (follow-up) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in Functional Status | Functional status will be evaluated using the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire. | Changes in Functional Status Baseline, 4 weeks, 8 weeks, and 12 weeks (follow-up) | 
| Changes in Cervical Range of Motion | Cervical range of motion will be assessed using a goniometer. | Baseline, 4 weeks, 8 weeks, and 12 weeks (follow-up) | 
| Changes in Quality of Life | Quality of life will be assessed using the Short Form-36 (SF-36) questionnaire | Changes in quality of life at Baseline, 4 weeks, 8 weeks, and 12 weeks (follow-up)aseline, 4 weeks, 8 weeks, and 12 weeks (follow-up) |