Acute Cerebrovascular Events Secondary to Patients Undergoing Catheter Ablation to Arrhythmias

Study Overview
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Brief Summary
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With the steady development of catheter ablation, it has gradually become the main treatment of various arrhythmias. Antithrombotic and anticoagulant therapy after catheter ablation determines the occurrence of perioperative bleeding and ischemic events. However, the incidence, characteristics and short-term prognosis of secondary acute cerebrovascular events in patients with arrhythmia after catheter ablation have not been studied. Methods: This study was intended to retrospectively collect and analyze the case data and auxiliary examination results of patients with arrhythmia who underwent catheter ablation. To evaluate the incidence, clinical features and short-term prognosis of secondary acute ischemic and hemorrhagic cerebrovascular events in patients with arrhythmia after catheter ablation. In order to improve the quality of life of patients, reduce the secondary acute cerebrovascular complications in the hospital in patients with arrhythmia after catheter ablation, to provide evidence for promoting the clinical management of such patients, and to provide help for the maximum degree of prevention and control risk.

Official Title
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Acute Cerebrovascular Events Secondary to Patients Undergoing Catheter Ablation to Arrhythmias (URGENT): an Investigator-initiated, National Multicenter Real-world Study

Conditions
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Arrhythmia, Ischemic Stroke, Hemorrhagic Stroke

Intervention / Treatment
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* Procedure: Radiofrequency catheter ablation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1.Clinical diagnosis of acute cerebrovascular disease secondary to radiofrequency catheter ablation. 2.Hospitalized from January 2018 to September 2022. Exclusion Criteria: 1. Patients were diagnosed of acute cerebrovascular disease prior to radiofrequency catheter ablation. 2. Patients refuse to take follow-up interviews.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Ischemic stroke group<br>Ischemic stroke secondary to patients receiving cardiac electronic implants Ischemic stroke met the diagnostic criteria of the 2018 edition of the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke, and was confirmed by cranial CT/MRI scan. | Procedure: Radiofrequency catheter ablation<br>* Catheter ablation has traditionally been used primarily in isolated Supraventricular tachycardias (SVT), atrioventricular nodal reentry tachycardias (AVNRT) are the most common paroxysmal SVTS. In recent years, the pathophysiological understanding of SVTS and catheter ablation have steadily advanced. Radiofrequency catheter ablation currently dominates AVNRT due to the high recurrence rate after cryoablation.<br>|
| Transient ischemic attack group<br>Transient ischemic attack secondary to patients receiving cardiac electronic implants Ischemic stroke met the diagnostic criteria of the 2018 edition of the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke, and was confirmed negative of new onset of infarction by cranial CT/MRI scan. | Procedure: Radiofrequency catheter ablation<br>* Catheter ablation has traditionally been used primarily in isolated Supraventricular tachycardias (SVT), atrioventricular nodal reentry tachycardias (AVNRT) are the most common paroxysmal SVTS. In recent years, the pathophysiological understanding of SVTS and catheter ablation have steadily advanced. Radiofrequency catheter ablation currently dominates AVNRT due to the high recurrence rate after cryoablation.<br>|
| Cerebral hemorrhage group<br>Cerebral hemorrhage secondary to patients receiving cardiac electronic implants Cerebral hemorrhage met the diagnostic criteria of the 2021 Chinese Guidelines for the Diagnosis and Treatment of cerebral hemorrhage and was confirmed by head CT/MRI. | Procedure: Radiofrequency catheter ablation<br>* Catheter ablation has traditionally been used primarily in isolated Supraventricular tachycardias (SVT), atrioventricular nodal reentry tachycardias (AVNRT) are the most common paroxysmal SVTS. In recent years, the pathophysiological understanding of SVTS and catheter ablation have steadily advanced. Radiofrequency catheter ablation currently dominates AVNRT due to the high recurrence rate after cryoablation.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The prevalence of acute cerebrovascular disease | Number and rate of patients with acute cerebrovascular disease secondary to patients receiving radiofrequency catheter ablation | up to 4 weeks in hospital | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| In-hospital mortality | In-hospital mortality of acute cerebrovascular disease in patients receiving radiofrequency catheter ablation | up to 4 weeks in hospital | 
| all-cause mortality | all-cause mortality within 3 months of telephone follow-up | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Radiofrequency catheter ablation, Arrhythmia, Stroke