Effect of Glycopyrrolate on Nausea and Vomiting After ERCP Operation

Study Overview
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Brief Summary
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This study aims to determine the role of Glycopyrrolate in preventing postoperative nausea and vomiting of ERCP.

Detailed Description
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This study is a prospective, double-blind, randomized controlled trial. Patients who meet the criteria of our center and need to undergo ERCP lesion resection will be included and randomly divided into groups. After receiving Glycopyrrolate (experimental group) and Anisodamine (control group), duodenal peristalsis, biliary and pancreatic treatment time and postoperative nausea and vomiting will be observed during therapeutic ERCP. The inhibitory effect of Glycopyrrolate on postoperative nausea and vomiting of ERCP will be analyzed statistically. Main outcome measure: incidence of nausea and vomiting after ERCP Secondary outcome measures: mean duodenal contractions per minute, duodenal spasm frequency and score, ERCP operation time, occurrence of other side effects of medication, remedial medication, and incidence of adverse events

Official Title
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Effect of Glycopyrrolate on Nausea and Vomiting After ERCP Operation

Conditions
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PIK3CA E545A

Intervention / Treatment
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* Drug: Glycopyrrolate
* Drug: Anisodamine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1.Adults 18-80 years old 2.ASA :I-III 3.Patients who are able to give informed consent and are currently planning to have the lesion removed or examined at the descending ERCP Exclusion Criteria:1: Use of anticholinergic drugs 2: pregnancy 3: glaucoma 4: Myasthenia gravis 5: Obstructive gastrointestinal diseases 6: Obstructive urinary tract disease (prostatic hyperplasia) 7: Heart disease (arrhythmia, coronary heart disease, congestive heart failure) 8: hyperthyroidism 9: Previous history of abdominal or intestinal surgery 10: Chronic renal failure -

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Glycopyrrolate<br>During induction of anesthesia, 0.2mg Glycopyrrolate was given intravenously to participants. | Drug: Glycopyrrolate<br>* During induction of anesthesia, 0.2mg Glycopyrrolate was given intravenously<br>|
| Active Comparator: Anisodamine Group<br>During induction of anesthesia,10mg of Anisodamine was given intramuscular injection | Drug: Anisodamine<br>* During induction of anesthesia,10mg of Anisodamine was given intramuscular injection.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of postoperative nausea and vomiting |  | Timepoint：24 hours after the ERCP |