The Comparison Between Computed Tomography and Colonoscope in Detecting Colorectal Tumors in Patients With FIT+

Study Overview
=================
Brief Summary
-----------------
Colonoscopy is the mainstay modality of choice in colorectal cancer screening worldwide. However, the rate of colonoscopy for colorectal cancer screening is very low (approximately 5-10%) because of the limited local medical resources (such as endoscopists and regional endoscope). This observational diagnostic test study aims to compare the diagnostic yield of routine computed tomography and colonoscopy in detecting colorectal tumors in patients at risk of colorectal cancer (aged more than 50 years and FIT+). The main question[s] it aims to answer are: To compare the diagnostic yield between the routine computed tomography and colonoscopy. To compare the procedure-related adverse events between the routine computed tomography and colonoscopy.

Detailed Description
-----------------
All enrolled patients underwent routine CT scans of whole abdomen, then subsequently under went a colonoscopy on the next day

Official Title
-----------------
The Comparison of Diagnostic Yield Between Routine Computed Tomography and Colonoscope in Detecting Colorectal Tumors in Patients Who at Risk of Colorectal Cancer

Conditions
-----------------
Patients at Risk of Colorectal Cancer

Intervention / Treatment
-----------------
* Diagnostic Test: CT and colonoscopy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Fit test + Normal platelet count and normal result of PT, PTT Exclusion Criteria: pregnancy or lactation uncontrolled Diabetes Mellitus, hypertension, asthma, congestive heart failure recent coronary artery disease within 3 months eGFR lesser than 30 mL/min/1.73m2 hemophilia or uncontrolled or uncorrected coagulopathy

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cohort1<br>Patients with aged more than 50 years and had FIT test + | Diagnostic Test: CT and colonoscopy<br>* All patients were admitted and worked up as inpatient cases. A blood test was obtained and a CT whole abdomen was performed for all patients in the evening. On the next day, all patients were prescribed for bowel preparation in the morning, then subsequently underwent colonoscopy in the afternoon.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic yield in diagnosis colorectal tumor | Sensitivity, specitivity, accuracy | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Procedure-related adverse events | Procedure-related adverse events such as, contrast induced nephropathy, contrast allergy, colonoscope-related perforation, post polypectomy bleeding | 2 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
colorectal tumor, colorectal cancer, CT scan, colonoscopy