linjc16/ctgov huggingface dataset:
Predictive Role of [11C] Choline PET/CT on Survival in Prostate Cancer Patients With Biochemical Failure.

Study Overview
=================
Brief Summary
-----------------
Several studies have shown that the PET/CT study with Choline is of great use in the restaging of patients with prostate cancer who present a recurrence of biochemical disease following primary treatment. Despite the large amount of literature in which the diagnostic accuracy of the method is highlighted in the identification of the recurrence of prostatic disease both in the case of local recurrence, lymph node recurrence and metastatic disease, there are to date no studies that evaluate whether PET /CT with choline may predict survival in patients radically treated for prostate cancer. The aim of the study is to evaluate the predictive role of choline PET/CT on the survival of patients with biochemical recovery of the disease during hormonal therapy. This retrospective study will include adult patients affected by prostate cancer with biochemical recurrence of the disease following radical prostatectomy treatment and undergoing hormonal therapy who underwent, between 2004 and 2007, a PET/CT study with choline for the restaging of their disease. The expected result is to establish how PET/CT with Choline can predict survival in patients who develop a biochemical recurrence of the disease during hormonal therapy. If this result is confirmed, PET/CT with Choline could be even more useful in the follow-up of patients radically treated for prostate cancer to plan the best therapeutic approach.

Official Title
-----------------
Predictive Role of [11C] Choline PET/CT on Survival in Prostate Cancer Patients With Biochemical Failure.

Conditions
-----------------
Prostate Cancer

Intervention / Treatment
-----------------
* Diagnostic Test: PET/CT with choline in the restaging phase of prostate cancer.


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients who have been treated with radical prostatectomy; patients who present a progressive increase in PSA value during hormonal treatment. Exclusion Criteria: patients< 18 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Male

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: PET/CT with choline in the restaging phase of prostate cancer.|PET/CT with choline in the restaging phase of prostate cancer in patients suffering from prostate cancer with biochemical recovery of the disease during hormonal therapy.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PET CT with choline on the survival of patients with biochemical recovery of prostate cancer | PET CT with choline on the survival of patients with biochemical recovery of the disease during hormonal therapy. | 1 year |
Effectiveness Of MM & Kinesotaping In The Female Patients Of KO To Improve Pain & Functional Mobility RCT

Study Overview
=================
Brief Summary
-----------------
to find out the Effectiveness Of Mobilization With Movement And Kinesotaping In The Female Patients Of Knee Osteoarthritis To Improve Pain And Functional Mobility

Official Title
-----------------
Effectiveness Of Mobilization With Movement And Kinesotaping In The Female Patients Of Knee Osteoarthritis To Improve Pain And Functional Mobility: A Randomized Controlled Trial

Conditions
-----------------
Knee Osteoarthritis

Intervention / Treatment
-----------------
* Diagnostic Test: Mobilization With Movement
* Diagnostic Test: Kinesotaping


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: · Female patients of age ranging from age above 50 years suffering from knee Osteoarthritis will be included Exclusion Criteria: · Patients suffering from any type of Cancer effecting area at which treatment will be applied. Patients having joint replacement or knee disease effecting the performance. Having skin allergies to taping.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Mobilization With Movement<br>Mobilization With Movement for Female Of Knee Osteoarthritis To Improve Pain And Functional Mobility | Diagnostic Test: Mobilization With Movement<br>* Mobilization With Movement Female Of Knee Osteoarthritis To Improve Pain And Functional Mobility<br>|
| Experimental: Kinesotaping<br>Kinesotaping for Female Of Knee Osteoarthritis To Improve Pain And Functional Mobility | Diagnostic Test: Kinesotaping<br>* Kinesotaping Female Of Knee Osteoarthritis To Improve Pain And Functional Mobility<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| KOOS | 42 itens Questioner for Knee injury and Osteoarthritis Outcome Score | 6 Months | 
| Li Scale | Lequesne Index is an11-item questionnaire designed to obtain information of a subjective nature, | 6 Months |
A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes

Study Overview
=================
Brief Summary
-----------------
The purpose of the study is to evaluate the safety, tolerability, and efficacy of VX-264 in participants with type 1 diabetes (T1D).

Official Title
-----------------
A Phase 1/2 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-264 in Subjects With Type 1 Diabetes Mellitus

Conditions
-----------------
Type 1 Diabetes

Intervention / Treatment
-----------------
* Drug: VX-264


Participation Criteria
=================
Eligibility Criteria
-----------------
Key Inclusion Criteria: Clinical history of T1D with greater than (>) 5 years duration Participant is on a stable diabetic treatment Consistent use of continuous glucose monitoring (CGM) for at least 4 weeks before Screening and willingness to use CGM for the duration of the study Key Exclusion Criteria: Prior islet cell transplant, organ transplant, or cell therapy Other protocol defined Inclusion/Exclusion criteria may apply.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: VX-264<br> | Drug: VX-264<br>* Allogeneic human stem cell-derived islets.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Part A and Part B: Safety and Tolerability as Assessed by Number of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs) |  | From Day 1 up to 24 months | 
| Part B and Part C: Change in Peak C-peptide during Mixed-Meal Tolerance Test (MMTT) |  | From Baseline and at Day 90 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Part C: Change in peak C-peptide during MMTT |  | From Baseline up to 24 months | 
| Part C: Change in Average Total Daily Insulin Dose |  | From Baseline up to 24 months | 
| Part C: Proportion of Participants who are Insulin Independent at One Point in Time |  | From Day 180 up to Day 365 | 
| Part C: Change in HbA1c values |  | From Baseline up to 24 months |
Management of Perforated Peptic Ulcer

Study Overview
=================
Brief Summary
-----------------
Perforated peptic ulcer (PPU) is a common surgical emergency. Exploratory laparotomy and repair with the omental patch are routine surgical intervention till now. In developing counties, laparoscopic repair is still not considered the gold standard in this emergency condition. This study was conducted to evaluate laparoscopic management of PPU in terms of peri-operative outcomes.

Detailed Description
-----------------
Files of all patients admitted to our hospital with perforated peptic ulcer in the last 4 years and underwent operative management. Demographic, clinical and perioperative outcomes will be collected tabulated and analyzed.

Official Title
-----------------
Laparoscopic Management of Perforated Peptic Ulcer: Multicenter Experience

Conditions
-----------------
Perforated Peptic Ulcer

Intervention / Treatment
-----------------
* Procedure: Repair of perforated peptic ulcer


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - All patients with perforated peptic ulcer admitted to our hospital in last 4 years and underwent surgical intervention. Exclusion Criteria: Uncompleted patents files.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Repair of perforated peptic ulcer|Repair of perforated peptic ulcer either open or laparoscopic.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Operative time | Time from skin incision to skin closure | 2 hours | 
| Leakage | Leakage from the repair | 5 days | 
| Time to return to normal daily activities. | Time to return to normal daily activities after surgery. | 2 weeks | 
| Perioperative complications | Any encountered perioperative complications related to surgical intervention.. | 1 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Peptic ulcer, Laparoscopic repair, Open repair, Graham Patch
Impact of Schemas, Cognitive Emotion Regulation on Quality of Life of HIV Patients: Assessing Outcomes of CBT

Study Overview
=================
Brief Summary
-----------------
The present study has investigated the impact of schemas, cognitive emotion regulation and social connectedness on the Quality of life of HIV patients in South Punjab region, Pakistan.

Detailed Description
-----------------
The present study has investigated the impact of schemas, cognitive emotion regulation and social connectedness on the Quality of life of HIV patients in South Punjab region, Pakistan. The main study was conducted in four steps as follows: Step 1: Pre-testing, N=150 Baseline assessment Random assignment of willing participants to control and experimental Step 2: CBT Intervention, N=40, 20 each group Step 3: post-test Step 4: Follow up Assessmen

Official Title
-----------------
Impact of Schemas, Cognitive Emotion Regulation on Quality of Life of HIV Patients: Assessing Outcomes of CBT

Conditions
-----------------
Quality of Life

Intervention / Treatment
-----------------
* Behavioral: CaCBT


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Registered at ART clinics South Punjab region HIV Patients Stage 1 or stage 2 Understands urdu Age above 20 Exclusion Criteria: AIDS converted No Other terminal illness No other diagnosis Below 20 age

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Repeated measures design
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control group<br>treatment as usual | |
| Experimental: Experimental group<br>CaCBT | Behavioral: CaCBT<br>* Culturally adapted Self help guide and modules total eight 80 hour session per week<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Social Connectedness Scale SCS-R | To measure social connectedness | 8 months | 
| WHOQOL-HIV Bref | HiV patients Quality of life will be enhanced | 8 months | 
| Schema Mode Inventory | This helped to measure schemas | 8 months | 
| CERQ | To measure cognitive emotion regulation strategies | 8 months | 
| WHOQOL | After intervention on HIV patients, Quality of Life will be enhanced as an outcome of the CBT intervention | 8 months |
Duration of Dual Antiretroviral Therapy in Virologically Suppressed People Living With HIV and Factors Associated With Switching to Tritherapy : a Real-life Cohort

Study Overview
=================
Brief Summary
-----------------
HIV infection requires lifelong continuous antiretroviral (ARV) treatment. The efficacy of current ARV treatments makes it possible to propose strategies for reducing the cumulative exposure to ARVs, side effects and costs. And so improve the quality of life of people living with HIV (PLHIV). However, in the real world, less regular adherence to treatment, more heavily pre-treated patients and resistance to treatment make these dual therapies prescribed beyond the strict framework of clinical trials. This can lead to undesirable side effects. From the perspective of personalized medicine, it seems to be important to determine which patients are receiving dual ARV therapy, and which patients remain on it for a long time. Identifying prognostic factors would enable us to adapt therapeutic management.

Official Title
-----------------
Duration of Dual Antiretroviral Therapy in Virologically Suppressed People Living With HIV and Factors Associated With Switching to Tritherapy : a Real-life Cohort

Conditions
-----------------
HIV Infections

Intervention / Treatment
-----------------
* Other: dual therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: hiv patient viral load < 50copies/ml patient treated with dual therapy patients with hospital follow-up between 2011 and 2023 Exclusion Criteria: adults under legal protection underage

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: dual therapy|The evaluation will focus on the retention of patients living with hiv on dual antiretroviral therapy.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| therapeutic switch | Proportion of patients switching from dual to triple therapy | 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
epidemiology
MRI Analysis and Degenerative Spine

Study Overview
=================
Brief Summary
-----------------
Analysis of MRI advanced techniques in degenerative spinal disease. The main questions it aims to answer are: Can we assess microstructural integrity of compressed nerve roots in degenerative spinal disease What are the image biomarkers affected by disease How they evolve with disease progression and treatment

Official Title
-----------------
MRI Analysis and Degenerative Spine

Conditions
-----------------
Spine Disease

Intervention / Treatment
-----------------
* Diagnostic Test: MRI advanced techniques


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age between 50 and 85 years Diagnosis of spinal disease by clinical and imagiological criteria More than 3 months duration of disease Ability to give consent Fluent portuguese speaker Exclusion Criteria: Previous spine surgery Spinal instability Neurological disease that might interfere with walking Known orthopedic conditions that causes significant gait impairment Dementia or development disorder with cognitive impairment Inability to give consent

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Healthy volunteers | Diagnostic Test: MRI advanced techniques<br>* Participants will be submitted to MRI studies at diagnosis, during disease evolution and after treatment. Data collected will be analysed by two different neuroradiologists using advanced techniques.<br>|
| Disease<br>Patients affected by disease | Diagnostic Test: MRI advanced techniques<br>* Participants will be submitted to MRI studies at diagnosis, during disease evolution and after treatment. Data collected will be analysed by two different neuroradiologists using advanced techniques.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ODI - Oswestry Disability Index | Measured using the ODI scale (range 0 - 50) | 18 months | 
| Lumbar Pain Intensity | Measured using the Numeric Pain Rating Scale (range: 0 - 10 ) | 18 months |
Virtual Reality Mindfulness in Preoperative Anxious Patients

Study Overview
=================
Brief Summary
-----------------
The goal of this interventional study is to reduce preoperative anxiety by Virtual Reality mindfulness. Population: all adults, able to give their consent and scheduled for surgery with high preoperative anxiety defined by Amsterdam Preoperative Anxiety and Information Scale (APAIS) score > 10. The study will recruit 100 patients in one university teaching hospital. The main question it aims to answer is: may mindfulness by Virtual Reality reduce preoperative anxiety in patients particularly anxious for the surgery? Participants will be asked to undergo to a single mindfulness virtual reality session before the surgery.

Official Title
-----------------
Virtual Reality Mindfulness in Preoperative Anxious Patients

Conditions
-----------------
Test Anxiety, Anxiety State, Preoperative Period

Intervention / Treatment
-----------------
* Device: Virtual Reality
* Other: application for mindfulness


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: adults able to give their consent, scheduled for elective surgery and with high preoperative anxiety defined by Amsterdam Preoperative Anxiety and Information Scale (APAIS) > 10 Exclusion Criteria: Pregnancy Epilepsy Pacemaker wearers Mental diseases Alcohol or drug addiction Severe hearing loss or blindness Simultaneous participation to other studies

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Virtual Reality<br>Each patient undergoes to a virtual reality session of mindfullness. This lasts about 30 minutes. | Device: Virtual Reality<br>* Use of this virtual reality headset to deliver a single mindfulness session<br>* Other names: Meta, Oculus 2;Other: application for mindfulness<br>* Application used to realize mindfulness in virtual reality<br>* Other names: Guided Meditation VR;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from one week before surgery in anxiety on STAI score some hours before the intervention | The State-Trait Anxiety Inventory (STAI) score is a validated, self reported instrument to assessing state and trait anxiety. Possible scores range from no or low anxiety (20-37) to high anxiety (45-80). Change = (one week before - some hours before the surgery and after mindfulness in virtual reality) | Up to two weeks |
Quantitative Neuromuscular Monitoring and Gastric Bypass Surgery

Study Overview
=================
Brief Summary
-----------------
This is a single site, prospective, non-blinded, non-randomized, before/after study. This study is designed to evaluate the impact of monitoring and reversal guidelines for neuromuscular blocking drugs on the post-operative outcomes for patients undergoing laparoscopic gastric bypass surgery.

Official Title
-----------------
A Before/After Study of the Impact of Quantitative Neuromuscular Monitoring and Sugammadex Reversal Following Gastric Bypass Surgery

Conditions
-----------------
Sugammadex

Intervention / Treatment
-----------------
* Device: Quantitative Neuromuscular Function Monitoring


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age greater than 18 years scheduled for an elective laparoscopic gastric bypass procedure Exclusion Criteria: age less than 18 years pregnancy prisoners significant co-existing lung disease including asthma or chronic obstructive pulmonary disease (COPD) requiring regular medication patients who require supplemental oxygen pre-operatively to maintain a hemoglobin saturation (SpO2>98%)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Quantitative Neuromuscular Function Monitoring|Quantitative electromyographic (EMG) monitoring|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oxygen desaturation | Incidence and magnitude of significant oxygen desaturation | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The rate of compliance with muscle relaxant monitoring and reversal protocols | Rate of compliance (%) | 24 hours | 
| Total intraoperative rocuronium use | Total dose/kg/hr (mg/kg/hr) | 24 hours | 
| Total sugammadex dose | Total dose (mg/kg) | 24 hours | 
| Post-operative supplemental oxygen requirement | Oxygen requirement (FiO2%/hr) | 24 hours | 
| Post-operative unit length of stay | Length of stay (Hours) | 7 days | 
| Hospital Length of stay | Length of stay (Hours) | 7 days | 
| Success rate for wearable device | Rate of compliance (%) | 24 hours |