Screening for Lung Cancer in Subjects With Family History of Lung Cancer

Study Overview
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Brief Summary
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Lung cancer can be detected via screening of high-risk individuals, i.e current or ex-heavy smokers, with low-dose computer tomography (LDCT) of thorax. The National Lung Screening Trial in US and the NELSON trial in Europe demonstrated reduction in lung cancer mortality with LDCT screening for lung cancer. In Hong Kong, however, there is a prominence of female never-smokers with lung cancer. There is no identifiable risk factors for non-smokers with lung cancer except family history of lung cancer. The hypothesis is that lung cancer screening for subjects with family history of lung cancer, can detect early lung cancer.

Detailed Description
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The primary aim of this prospective study is to find out the rate of lung cancer detection in subjects who are first degree relatives of lung cancer patients. Secondary aims include studying the characteristics of screen-detected lung cancer. This is a multi-centered prospective cohort study. 1,520 subjects who are first degree relatives of lung cancer patients at four public hospitals in Hong Kong will be screened. Intervention Detailed questionnaires and LDCT Thorax will be performed. The primary outcome measure is the number of lung cancers detected by this study. The screening-detection rate of lung cancer in first-degree relatives of lung cancer patients will be estimated.

Official Title
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Screening for Lung Cancer in Subjects With Family History of Lung Cancer

Conditions
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Lung Cancer

Intervention / Treatment
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* Diagnostic Test: Low dose CT thorax
* Diagnostic Test: Low dose CT thorax


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 50-75, men or women, smokers or non-smokers Being first degree relatives (Siblings, children, and parents) of lung cancer subjects Having no known lung cancer before Exclusion Criteria: Non-Chinese Mentally incompetent to give informed consent

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| First degree relatives of lung cancer patients<br>Age 50-75, men or women, smokers or non-smokers. Being first degree relatives (siblings, children and parents) of lung cancer subjects. Having no known lung cancer before. | Diagnostic Test: Low dose CT thorax<br>* A multi-detector row CT scanner with minimum section collimation of ≤1 mm and minimum number of data acquisition channels ≥ 16will be employed.<br>|
| Control group<br>Non-lung cancer subjects who are not related any lung cancer patients | Diagnostic Test: Low dose CT thorax<br>* Control subjects will also proceed to CT thorax, and outcome measures be compared to subjects<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The rate of lung cancer detection in subjects with family history of lung cancer | The number of screening-detected lung cancer among first degree relatives of lung cancer patients. | An average of 2.5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The characteristics of screening detected lung cancer | Stage distribution of lung cancer detected. | An average of 2.5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lung cancer, Screening, Family history