Serratus Plane Block Versus Serratus Plane Block Plus Parasternal Block Combination for Breast Surgery

Study Overview
=================
Brief Summary
-----------------
Mastectomy is a technique often used in breast cancer surgery. Patients experience moderate to severe pain postoperatively after this procedure. Various plane blocks, NSAIDs, and opioid analgesics can be administered to these patients as components of multimodal analgesia. In the the study, the investigators aimed to evaluate the analgesic effects of the serratus plane block, the parasternal block added to the serratus plane block, and the dermatomal differences.

Official Title
-----------------
Serratus Plane Block Versus Serratus Plane Block Plus Parasternal Block on Postoperative Opioid Consumption and Dermatomal Analyses for Breast Surgery

Conditions
-----------------
Analgesia, Cancer, Breast

Intervention / Treatment
-----------------
* Other: group serratus plan block
* Other: group serratus and parasternal plan block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: American Society of Anesthesiologist's physiologic state I-III patients To undergo Mastectomy Surgery Being between the ages of 18-65 years Exclusion Criteria: Having a known heart, kidney, liver or hematological disease Having a history of peptic ulcer, gastrointestinal bleeding, allergy, chronic pain Routine analgesic use and history of analgesic use in the last 24 hours Not willing to participate in the study Uncooperative patients who have coagulopathy or use anticoagulant drugs To be allergic to one of the drugs to be used

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: group serratus<br>preoperative superficial serratus block with local anaesthetics and parasternal block with saline | Other: group serratus plan block<br>* preoperativelly, Superficial Serratus Block performed with 30 ml %0.25 Bupivacaine and Parasternal Block performed with 10 ml saline<br>|
| Active Comparator: group serratus and parasternal<br>preoperative superficial serratus block and parasternal block with local anaesthetics | Other: group serratus and parasternal plan block<br>* preoperativelly, Superficial Serratus Block performed with 30 ml %0.25 Bupivacaine and Parasternal Block performed with 10 ml %0.25 Bupivacaine<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative opioid consumption | First 24 hours total fentanyl consumption with patient controlled analgesia | first 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual analog pain score | Post operative pain will be evaluated with a Visual Analogue Scale (between 0-10; 0: no pain, 10:worst pain) score | First 24 hours | 
| Sensory Assessment | Sensory Assessment will be performed on patients following the block procedure with pinprick test. | 24 hours |