Survival and Predictive Factors of Clinical Outcome in Patients With Acquired Brain Injury

Study Overview
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Brief Summary
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The prediction of the final neurological and functional status of patients with acquired brain injury remains very uncertain despite the findings of current medicine. The aim of the study is to evaluate the clinical outcomes in patients with the most severe degree of brain injury hospitalized in the long-term intensive care unit of the Military University Hospital Prague.

Detailed Description
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The prediction of the final neurological and functional status of patients with acquired brain injury remains very uncertain despite the findings of current medicine. Current medical knowledge is particularly limited in patients with the most severe brain injury who had to be tracheostomized and admitted to long-term intensive care unit. In the Czech Republic, there is a complete lack of data on clinical outcomes in these patients. Some recent studies has not confirmed the long-standing better outcome in patients with traumatic brain injury compared to non-traumatic etiologies. The aim of the study is to evaluate the clinical outcomes in patients with the most severe degree of brain injury hospitalized in the long-term intensive care unit of the Military University Hospital Prague.

Official Title
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Survival and Predictive Factors of Clinical Outcome in Patients With Acquired Brain Injury

Conditions
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Acquired Brain Injury

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Acquired brain injury Initial Glasgow Coma Scale (GCS) score less than 8 points Tracheostomy for persistent impairment of consciousness Exclusion Criteria: none

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Trauma brain injury<br>Patients with acquired brain injury of traumatic etiology. | |
| Non-trauma brain injury<br>Patients with acquired brain injury of non-traumatic etiology. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Level of consciousness achieved | Initial Glasgow coma scale (GCS) and GCS at discharge. Minimal points 3, maximal point 15. The higher the score the better the outcome. | three months | 
| Level of self-sufficiency | Initial level of self-sufficiency and self-sufficiency at discharge using Barthel score. 0-100 points. A patient scoring 100 points is continent, feeds himself, dresses himself, gets up out of bed and chairs, bathes himself, walks at least a block, and can ascend and descend stairs. A score of 0 means that the patient does not meet any of the activities described above. | three months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of survival after discharge from intensive care. | Length of survival after discharge from intensive care. In days. | three months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acquired brain injury, consciousness disorders, prognosis, persistent vegetative state