Neurofeedback and Neural Plasticity of Self-Processing and Affect Regulation Circuits in Suicide Attempting Adolescents

Study Overview
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Brief Summary
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A non invasive treatment study including participants at risk for suicide attempts and undergoing neurofeedback training. Neurofeedback is controlling your brain activity in real time inside the scanner.

Official Title
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Neurofeedback and Neural Plasticity of Self-Processing and Affect Regulation Circuits in Suicide Attempting Adolescents

Conditions
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Suicide, Attempted, Suicide, Ideation, Depression

Intervention / Treatment
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* Other: neurofeedback training involving dACC
* Other: neurofeedback training involving amygdala


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adolescents with a history of suicide attempts Exclusion Criteria: Psychotic disorders. Primary substance use disorder. Primary anorexic disorder. Autism Spectrum Disorder.

Ages Eligible for Study
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Minimum Age: 11 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Parallel Assignment
Interventional Model Description: Comparing two different targets of treatment: either amygdala or dorsal anterior cingulate cortex neurofeedback
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: dACC Arm<br>Participants assigned to the Neurofeedback from the dorsal anterior cingulate cortex | Other: neurofeedback training involving dACC<br>* Participants are pseudorandomized to the dACC group to undergo neurofeedback (NF). NF training consists of four  7.33 min NF training runs preceded by a 5 min baseline (no NF) and followed by a 5 min transfer run (no NF). Training entails NF blocks paired to a self-happy face along a bar that indicates changing levels of the dACC. During the control condition, participants will count backward (CB) from 100 cued by an unfamiliar happy face with no NF. During rest conditions, participants see the cue Rest and are asked to relax with their eyes open. During NF, participants will try to increase dACC neural activity by recalling happy memories. The colored bar indicating the neural activity will shift up or down depending on values provided by Turbo-BrainVoyager software. Green = Activity > baseline and red = Activity < baseline. Before and after NF training, suicide ideation severity, depression severity, and performance on self-processing behavioral tasks will be assessed.<br>|
| Experimental: rAMY Arm<br>Participants assigned to the Neurofeedback from the amygdala | Other: neurofeedback training involving amygdala<br>* Participants are pseudorandomized to the rAMY group to undergo neurofeedback (NF). NF training consists of four  7.33 min NF training runs preceded by a 5 min baseline (no NF) and followed by a 5 min transfer run (no NF). Training entails NF blocks paired to a self-happy face along a bar that indicates changing levels of the rAMY. During the control condition, participants will count backward (CB) from 100 cued by an unfamiliar happy face with no NF. During rest conditions, participants see the cue Rest and are asked to relax with their eyes open. During NF, participants will try to increase rAMY neural activity by recalling happy memories. The colored bar indicating the neural activity will shift up or down depending on values provided by Turbo-BrainVoyager software. Green = Activity > baseline and red = Activity < baseline. Before and after NF training, suicide ideation severity, depression severity, and performance on self-processing behavioral tasks will be assessed.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| suicide ideation | suicide ideation questionnaire | 1 week and 1 month following intervention |