linjc16/ctgov huggingface dataset:
Safety and Efficacy of Facial Cleanser

Study Overview
=================
Brief Summary
-----------------
This study is conducted to evaluate the safety and effectiveness of facial cleanser X containing combination of olive oil, virgin coconut oil, butylene glycol and hyaluronic acid on skin hydration and skin elasticity. The study duration is 5 weeks and the skin assessment will be carried out at baseline, week 3 and week 5.The main questions this study aims to answer are: The effect of product on skin hydration. The effect of product on skin elasticity. To observe any adverse effect occurrence with the usage of the product.

Official Title
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The Safety and Efficacy of Facial Cleanser Containing Combination of Olive Oil, Virgin Coconut Oil, Butylene Glycol and Hyaluronic Acid on Skin Hydration and Skin Elasticity

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Other: Other: Product X facial cleanser


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Malaysia citizen Male and female (age 35-55 years old) Exclusion Criteria: Participants who have acne which require medical treatment. Participants taking isotretinoin Participants who had undergo any cosmetic procedures such as laser & light treatment, botulinum toxin A injections and chemical peeling for the past 3 months Participants who are immunocompromised Participants with history of facial surgery

Ages Eligible for Study
-----------------
Minimum Age: 35 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Product X facial cleanser<br>Participants will used Product X facial cleanser twice daily for 5 weeks | Other: Other: Product X facial cleanser<br>* Product X facial cleanser contain olive oil, virgin coconut oil, butylene glycol and hyaluronic acid<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in skin hydration from baseline and at week 3 and 5 after using facial cleanser X | Skin hydration will be assessed using JANUS III skin analyzer | Baseline, week 3 and week 5 | 
| Change in skin elasticity from baseline and at week 3 and 5 after using facial cleanser X | Skin elasticity will be assessed using JANUS III skin analyzer | Baseline, week 3 and week 5 | 
| Adverse effect after using facial cleanser X | Based on adverse effect occurrence on participants that occur during study period (5 weeks) | Week 5 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
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Aesthetic, Cosmetic
RASECAL-Bronchoscopic Ambusampler

Study Overview
=================
Brief Summary
-----------------
Prospective, multi-centre, open labelled, 1:1randomized controlled study.

Detailed Description
-----------------
Patients admitted to ICU with acute respiratory failure, requiring mechanical ventilation with, suspected or confirmed COVID-19. Patients admitted to ICU with acute respiratory failure due to a condition other than COVID-19, requiring mechanical ventilation.

Official Title
-----------------
A Randomized Controlled Trial to Assess the Safety and Efficiency of a Self-Contained Sampling Device /Disposable Bronchoscope System Versus Usual sampLing Procedure.

Conditions
-----------------
Respiratory Failure

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: (All are required) Clinicians experienced in performing bronchoscopies (i.e. bronchoscopists should have performed a minimum 5 bronchoscopies in mechanically ventilated patients and a minimum of 5 bronchoscopies in a simulated or practice setting). Clinicians who have undergone the online product-training module for the use of the Ambu Bronchosampler, with self-certification documented. Clinicians who have simulated the online product training module using an Ambu Bronchosampler and Ambu Ascope4 a minimum of 5 times in a practice setting and have self-certified. Population Patients ≥ 18 years old Patients on mechanical ventilation with Acute respiratory failure for >4h Patients eligible for a clinically indicated bronchoscopy with fluid sampling. Patient information has been explained and verbal or written consent has been obtained Exclusion Criteria: Investigators Investigators who have not completed product training in aScope BronchoSampler by online and hands-on from Ambu product specialists or an experienced user from the site. Investigators with experience in < 5 self-verified simulated fluid sampling procedures using the Ambu BronchoSampler 4.8.2 Population Clinician concern regarding safety of bronchoscopy Involved study personal not available to perform the procedure and enroll the patient

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of two sampling pots | Can the Ambu Bronchosampler improve safety versus usual standard care by reducing the risk of spillage or disconnection of the sampling system during a procedure? | 1month |
Magnetic Resonance Fingerprinting in the Imaging of Endometrial Cancer

Study Overview
=================
Brief Summary
-----------------
In this context, the aim of this study is to investigate the role of MRF in endometrial cancer. Several applications are possible. Firstly, T1-, T2- and DWI-mappings can be associated to molecular risk group classification, in order to stratify patients' risk without recurring to surgery. MRF parameters can be also correlated to prognosis, both in terms of disease-free survival (DFS) and overall survival (OS).

Official Title
-----------------
MARF-E- Magnetic Resonance Fingerprinting in the Imaging of Endometrial Cancer

Conditions
-----------------
Endometrial Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with biopsy-proven endometrial cancer; Women aged > 18 years old; Signed Informed consent. Exclusion Criteria: Previous history of neoplasm; Concurrent malignancies at other sites.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Association between T1-, T2- and diffusion-mappings and risk group classification |  | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic accuracy of T1-,T2- and diffusion-mappings deriving from MRF in myometrial invasion detection |  | 3 months | 
| Correlation between T1-, T2- and diffusion mappings and DFS and OS |  | 3 years | 
| Diagnostic accuracy of T1-,T2- and diffusion-mappings and pathological nodal involvement |  | 3 months | 
| Evaluation of Radiomic and Radiogenomic models to predict recurrence in early stage EC and to predict DFS and OS |  | 3 years |
The Value of Molecular Residual Disease Monitoring Based on ctDNA in Advanced or Metastatic Pancreatic Cancer

Study Overview
=================
Brief Summary
-----------------
The goal of this clinical trial is to explore the value of molecular residual disease (MRD) monitoring based on ctDNA in advanced or metastatic pancreatic cancer. The main questions it aims to answer are: prognostic value of baseline MRD; the role of MRD dynamic changes after treatment in guiding treatment. Peripheral blood derived from participants will be obtained for MRD test before first-line chemotherapy initiation and at the first imaging assessment after chemotherapy.

Official Title
-----------------
The Value of Molecular Residual Disease Monitoring Based on ctDNA in Advanced or Metastatic Pancreatic Cancer

Conditions
-----------------
Pancreatic Cancer, Advanced Cancer, Metastatic Cancer

Intervention / Treatment
-----------------
* Drug: Later-line therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with histologically confirmed unresectable advanced or metastatic pancreatic cancer; both sexes, age ≥18 years old; ECOG performance status score ≤2; the expected survival time was ≥3 months. Exclusion Criteria: a known diagnosis of pancreatic cancer other than ductal adenocarcinoma; treated with any systemic antitumor treatment before first-line chemotherapy onset; died or lost to follow-up within one month after the initiation of first-line chemotherpay; combined with other primary malignances.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MRD-guided<br>Patients with elevated MRD from baseline at the first imaging assessment but without radiographic progressive disease will receive a later-line therapy. | Drug: Later-line therapy<br>* Another chemotherapy regimen, targeted therapy, or immunotherapy<br>|
| No Intervention: Routine treatment<br>Patients with elevated MRD from baseline at the first imaging assessment but without radiographic progressive disease will continued their current therapy. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression-free survival | The date of first-line chemotherpay initiation to tumor progression or death due to any cause in the absence of progression. | Baseline until death from any cause (up to approximately 24 months) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival | The date of first-line chemotherpay initiation to death due to any cause. | Baseline until death from any cause (up to approximately 24 months) |
ERAS Swallowing Rehabilitation in Elder Patients

Study Overview
=================
Brief Summary
-----------------
The investigators studied that swallowing function of patients receiving the Early Recovery Accelerated Swallowing (ERAS-W program) training will recover fast than that of patients in the control group. The ERAS program training will be initiated before surgery and continue to after surgery.

Detailed Description
-----------------
The older patients (≥65 years old) with OFI-8≥4 undergoing elective orthopedic surgery requiring tracheal intubation will be recruited. Patients will be randomized into an intervention and a control group. Patients in the intervention groups will received the ERAS-W program, while those in the control group will receive the swallowing education video.

Official Title
-----------------
Effectivity of Early Recovery Accelerated Swallowing Program on Promoting Swallowing Recovery in Older Patients With High Risk of Oral Frailty Requiring Endotracheal Intubation During General Anesthesia: a Pilot Randomized Control Trial

Conditions
-----------------
The Upper Esophageal Sphincter Contraction Strength

Intervention / Treatment
-----------------
* Behavioral: early rehabiliation swallowing program
* Behavioral: not receiving early rehabilitation swallowing program


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: elective surgery general anesthesia with endotracheal intubation Exclusion Criteria: major organ dysfunction, ex: chronic kidney disease, hear failure bleeding tendency

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Patients receive early recovery of swallowing rehabiliation before surgery and continued to after surgery
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: patients receiving early rehabiliation swallowing program<br>the early rehabilitation program beginning from before to after surgery | Behavioral: early rehabiliation swallowing program<br>* not receiving early rehabilitation swallowing program from before and after surgery<br>|
| Placebo Comparator: patients not receiving early rehabilitation swallowing program<br>the Taiwan Dysphagia Society's publicly shared swallowing exercises for dysphagia, which is started from before to after surgery | Behavioral: not receiving early rehabilitation swallowing program<br>* the Taiwan Dysphagia Society's publicly shared swallowing exercises for dysphagia, which is from before and after surgery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| UES pressure, mmHg |  | about six months |
Renal Doppler in Pediatric Patients With Idiopathic Nephrotic Syndrome

Study Overview
=================
Brief Summary
-----------------
The use of the renal resistive index in pediatric patient with idiopathic nephrotic syndrome to detect steroid resistance and to use it as a prognostic instrument of the progression of the disease.

Detailed Description
-----------------
Renal Doppler will be done for all children in supine and lateral positions using Toshiba Aplio ultrasound machine and renal resistive index will be measured (peak systolic velocity- end diastolic velocity/ peak systolic velocity) at diagnosis, after one month, 3 months and 6months, in which these values will be obtained by the ultrasound machine based on the computer algorithm. Also the kidneys will be scanned firstly for length, width, cortical thickness and echogenicity.

Official Title
-----------------
Renal Doppler in Detection of Steroid Resistance in Pediatric Patients With Idiopathic Nephrotic Syndrome

Conditions
-----------------
Nephrotic Syndrome

Intervention / Treatment
-----------------
* Device: renal doppler


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pediatric patients with primary nephrotic syndrome aged from 1 to 18 years Exclusion Criteria: - Patients with congenital nephrotic syndrome. Patients with secondary causes of nephrotic syndrome.

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: renal doppler|Toshiba Aplio ultrasound machine and renal resistive index will be measured (peak systolic velocity- end diastolic velocity/ peak systolic velocity|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| detection of steroid resistance in pediatric patients with idiopathic nephrotic syndrome | measurement of renal resistive index and detection of steroid sensitivity | 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| progression of nephrotic syndrome | frequent measurement of renal resistive index and using it as prognostic factor | six months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
renal doppler, nephrotic syndrome, steroid resistance
Needle Free Assessment of Myocardial Oxygenation in Healthy Subjects

Study Overview
=================
Brief Summary
-----------------
This is a prospective pilot study to evaluate the safety, tolerability and efficacy of utilizing precise computer controlled gas challenge in healthy subjects for identification of coronary artery disease.

Detailed Description
-----------------
This study will establish the safe and tolerable level of high PC02 and low P02 for future studies as potential stressors for coronary artery disease assessment.

Official Title
-----------------
A Prospective Pilot Study to Evaluate the Safety, Tolerability and Efficacy of Utilizing Precise Computer Controlled Gas Challenge in Healthy Subjects for Identification of Coronary Artery Disease

Conditions
-----------------
Coronary Artery Disease

Intervention / Treatment
-----------------
* Device: RespirAct


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults ≥ 45 years of age No known cardiac disease Exclusion Criteria: Low blood pressure (systolic blood pressure < 100 mmHg) Inability to voluntarily increase their breathing rate if prompted to do so Persons with the inability to lie supine for 30-40 minutes Persons who are pregnant, nursing, or implanted with intrauterine devices (IUD's) Persons with significant neurological, pulmonary, renal or hepatic disease Persons who have an abnormal cardiac rhythm or resting heart rate >100/min Inability or unwillingness to provide informed consent

Ages Eligible for Study
-----------------
Minimum Age: 45 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Healthy Subjects<br>Healthy subjects without a history of coronary artery disease will undergo computer-controlled gas challenges. | Device: RespirAct<br>* RespirAct device-based computer-controlled gas delivery at different concentrations as per protocol<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physiological Parameters Monitoring | Saturation of peripheral oxygen as percentage Heart rate as beats per minute Noninvasive blood pressure as mmHg Partial pressure of oxygen as mmHg Partial pressure of carbon dioxide as mmHg | 3 hours | 
| Assessment of Symptom Severity and Incidence | Chest pain Headache Dizziness Confusion Fatigue Upset stomach Nausea Vomiting | 3 hours |
Prevalence of Nerd Neck Between Different Students at Taibah University, Saudi Arabia

Study Overview
=================
Brief Summary
-----------------
A convenient sample of 82 female students aged 18-24 years participated in analytic observational experiment cross section design. Students were recruited into two groups, practical and non-practical. to answer the following Is there a difference in the prevalence of nerd neck between students of practical and non-practical studying groups at Taibah University from the sitting position? Is there a difference in the prevalence of nerd neck between students of practical and non-practical studying groups at Taibah University from the standing position?

Official Title
-----------------
Prevalence of Nerd Neck Between Different Students at Taibah University, Saudi Arabia; Cross Section Design

Conditions
-----------------
CERVICAL

Intervention / Treatment
-----------------
* Device: tragus to wall distance (TWD), craniovertebral angle (CVA) by smart phone application


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: A convenient sample of 82 female students the age was between 18-24 years Students were recruited from practical and non-practical faculties at taibah university. Exclusion Criteria: we excluded Any student with previous neck or back surgery or history of previous accident Also, any student with history of cervical column fracture injury, scoliosis, severe thoracic kyphosis, torticollis, persistent respiratory problems, rheumatic disease. also we excluded any student with loss of standing balance and user of hearing aid

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 24 Years

Sexes Eligible for Study
-----------------
Female

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| practical group<br> | Device: tragus to wall distance (TWD), craniovertebral angle (CVA) by smart phone application<br>* Applying photogrammetric method for CVA by smart phone application and measure nerd neck objectively from both sitting and standing positions. Also, tragus to wall distance method was used to detect degree of nerd neck from the standing position.<br>|
| non-practical group<br> | Device: tragus to wall distance (TWD), craniovertebral angle (CVA) by smart phone application<br>* Applying photogrammetric method for CVA by smart phone application and measure nerd neck objectively from both sitting and standing positions. Also, tragus to wall distance method was used to detect degree of nerd neck from the standing position.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the prevalence of nerd neck | we measured nerd neck by calculating CVA by tragus wall distance test from standing position | one day |