Evolution of Vestibular Function After Treatment of a Vestibular Schwannoma by Gamma-knife Radio-surgery

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the vestibular effects of gamma-knife radiosurgery, as part of the treatment of vestibular schwannoma.

Detailed Description
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Vestibular schwannoma is a benign tumor located on the vestibulocochlear nerve. It represents 6 to 8% of intracranial tumors, 80% of ponto-cerebral angle tumors and its frequency is 13 cases per million inhabitants per year. The main symptoms related to the development of vestibular schwannoma are unilateral deafness of perception, unilateral tinnitus, unilateral vestibular deficit vertigo, facial paralysis. Management is divided into 3 options: monitoring, surgery and gamma-knife radiosurgery. This study will focus on gamma-knife radiosurgery. The objective of this treatment is to stabilize the evolution of schwannoma. This study aims to describe the vestibular effects of radiosurgery.

Official Title
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Evolution of Vestibular Function After Treatment of a Vestibular Schwannoma by Gamma-knife

Conditions
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Vestibular Schwannoma, Neurinoma, Acoustic, Acoustic Neuroma

Intervention / Treatment
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* Other: Vestibular exam


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria : Men and women aged 18 to 90 included Subject who benefited from gamma-knife radiosurgery as part of the treatment of vestibular schwannoma Non-opposition of the subject to participate in the study Affiliation to a French social security scheme or beneficiary of such a scheme Exclusion Criteria : Subject with another vestibular pathology Subject who did not benefit from a vestibular assessment before treatment with gamma-knife radiosurgery Legal incapacity or limited legal capacity Subject unlikely to cooperate in the study and/or weak cooperation anticipated by the investigator Subject without health insurance Subject being in the period of exclusion from another study or provided for by the national volunteer file.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: Prognostic cohort study
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Radiosurgery<br> | Other: Vestibular exam<br>* Interrogation, videonystagmoscopy, videonystagmography, video-head-impulse-test<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Description of vestibular function with videonystagmography before gamma-knife radiosurgery, as part of the treatment of vestibular schwannoma. | Videonystagmography: Results of caloric tests = Intervestibular deficit (in percentage) | 1 month before gamma-knife radiosurgery | 
| Description of vestibular function with vidéonystagmoscopy before gamma-knife radiosurgery, as part of the treatment of vestibular schwannoma. | Videonystagmography: Results of caloric tests = Intervestibular deficit (in percentage) | After gamma-knife radiosurgery at 6 month or 12 month or 18 month or 2 years or 3 years depending on the history of the treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Description of vestibular symptoms before gamma-knife radiosurgery as part of the treatment of vestibular schwannoma. | Dizziness Handicap Inventoryquestionnaire (DHI questionnaire) | 1 month before gamma-knife radiosurgery | 
| Description of vestibular symptoms after gamma-knife radiosurgery as part of the treatment of vestibular schwannoma. | Dizziness Handicap Inventoryquestionnaire (DHI questionnaire) | After gamma-knife radiosurgery at 6 month or 12 month or 18 month or 2 years or 3 years depending on the history of the treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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vestibular, schwannoma, radiosurgery, gamma-knife, neurinoma, acoustic