Application of Intraoperative Transesophageal Echocardiography Imaging of Vein and CLCVP in Early Prediction and Intervention CSA-AKI

Study Overview
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Brief Summary
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The goal of this clinical trial is to learn about in postoperative acute kidney injury in cardiac surgery. The main questions it aims to answer are: Intraoperative Transesophageal Ultrasound Doppler venous imaging can be used to predict the occurrence of cardiac surgery associated acute kidney injury (CSA-AKI ) in the early stage by observing the changes of renal vein, portal vein and hepatic vein blood flow patterns, calculating the renal vein stasis index and portal vein pulsatility index, and evaluating the degree of venous congestion. Controlled low central venous pressure (CLCVP) technology can reduce the occurrence of CSA-AKI by reducing venous congestion and increasing renal perfusion pressure. Participants will receive Transesophageal Ultrasound Doppler during cardiac surgery. If the participant is assigned to the intervention group, if the central venous pressure of the participant is ≥ 10mmHg 30 minutes after the end of cardiopulmonary bypass, he will receive nitroglycerin pumped to apply the controlled low central venous pressure (CLCVP) technology; If participants are assigned to the control group, no intervention measures will be taken. The researchers will compare the intervention group with the control group to see the occurrence of AKI and AKD after cardiac surgery.

Official Title
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Application of Intraoperative Transesophageal Echocardiography Imaging of Vein and Controlled Low Central Venous Pressure in Early Prediction and Intervention of Acute Renal Injury Associated With Cardiac Surgery

Conditions
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Acute Kidney Injury

Intervention / Treatment
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* Combination Product: Controlled low central venous pressure (CLCVP) technology
* Drug: Nitroglycerin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged above 18 years undergoing coronary artery bypass graft or heart valve surgery under cardiopulmonary bypass. Exclusion Criteria: Patients with CKD history, end-stage renal disease and renal transplantation before operation Used nephrotoxic drugs within two weeks before operation Known Renal Artery Stenosis and Renal Malformations There are contraindications for transesophageal ultrasound Doppler evaluation of esophageal space occupying lesions

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention group<br>Controlled low central venous pressure (CLCVP) technology | Combination Product: Controlled low central venous pressure (CLCVP) technology<br>* Controlled low central venous pressure (CLCVP) technology: after cardiopulmonary bypass, pumping nitroglycerin (0.2-1 ug/kg * min) and other methods until the end of surgery to maintain the central venous pressure below 10 mmHg.<br>Drug: Nitroglycerin<br>* nitroglycerin (0.2-1 ug/kg * min)<br>|
| No Intervention: control group<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Level of Serum creatinine | SCR | Before operation to 90 days after operation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neutrophil gelatinase associated lipid transporter (NGAL) | Neutrophil gelatinase associated lipid transporter | Before operation to 2 hours after operation | 
| Kidney Injury Molecule-1 (KIM-1) | Kidney Injury Molecule-1 | Before operation to 12 hours after operation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute Kidney Injury, Acute Kidney Disease, Postoperative complications of cardiac surgery, Transesophageal echocardiography