Genetic Factors and CP Pregnancy Outcomes

Study Overview
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Brief Summary
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To explore the impact of chronic pancreatitis (CP) susceptibility genes on pregnancy outcomes.

Detailed Description
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The goal of this observational study is to explore the impact of CP susceptibility genes (SPINK1, PRSS1, CTRC, CFTR) on pregnancy outcomes (including both maternal and fetal outcomes) in a large Chinese cohort. Participants will be asked to provide their pregnancy-related data.

Official Title
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The Impact of Genetic Factors on Pregnancy Outcomes in Chronic Pancreatitis

Conditions
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Chronic Pancreatitis, Genetic Mutation, Pregnancy Related

Intervention / Treatment
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* Diagnostic Test: genetic sequencing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: female patients with a diagnosis of chronic pancreatitis have known genetic backgrounds and pregnancy history agree to join the study and provide informed consent Exclusion Criteria: patients without documented pregnancy patients who denied to provide pregnancy-related information, or with incomplete pregnancy characteristics and/or outcomes patients with other autoimmune comorbidities that might influence pregnancy outcomes, such as systemic lupus erythematosus, autoimmune thyroid diseases, etc
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: genetic sequencing|sequencing the susceptibility genes for CP, including serine protease inhibitor Kazal type 1, cationic trypsinogen, cystic fibrosis transmembrane conductance regulator, chymotrypsin C, etc.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| adverse maternal outcomes of female CP patients | CP-associated caesarean delivery referred to caesarean deliveries which happened due to the attack of CP or comorbidities associated with CP such as GDM and HDP. CP-associated preterm delivery was defined as preterm deliveries which happened due to the attack of CP or comorbidities associated with CP. GDM was defined as the onset or first recognition of abnormal glucose tolerance during pregnancy. Intrahepatic cholestasis of pregnancy was based on characteristic symptoms, as well as elevated serum bile acids, in the absence of other hepatobiliary disease. HDP included preeclampsia/eclampsia, chronic hypertension, chronic hypertension with superimposed preeclampsia, and gestational hypertension. | through study completion, an average of 1 year | 
| adverse fetal outcomes of female CP patients | Low birth weight was defined as weight at birth <2500 g. CP-associated abortion referred to abortions (i.e., a nonviable intrauterine pregnancy up to 20 weeks' gestation) which happened due to the attack of CP or comorbidities associated with CP. Congenital anomaly referred to the inborn errors of development. Stillbirth was defined as the delivery of a fetus ≥20 weeks of gestation with no signs of life. | through study completion, an average of 1 year |