Construction of Early Warning Model for the New Psychoactive Substances Using in Adolescents

Study Overview
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Brief Summary
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Based on the biological-psychology-sociological medicine pattern, this study aims to construction an early warning model of the New Psychoactive Substances (NPS) using for adolescents aged 14-35 years old. This study intends to obtain the data related to the behavioral expression of addiction susceptibility genes, adverse childhood experience, cognition, resistance and the use of NPS in adolescents by questionnaire survey (sample size: 200), and then use logistic regression and machine learning to construct an early warning model.

Detailed Description
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Based on the biological-psychology-sociological medicine pattern, this study aims to construction an early warning model on the use of the New Psychoactive Substances using for adolescents aged 14-35 years old. This study intends to conduct a questionnaire survey (sample size 200) to obtain data related to the behavioral expression of addiction susceptibility genes, childhood adversity experience, cognition, resistance and the use of NPS in adolescents from different regions and different populations. Through data analysis, this study aims to get the weight of different risk factors on NPS use, and then use logistic regression and machine learning to construct an early warning model, so as to screen out high-risk groups. At the same time, the expert group was consulted to establish a risk early warning system to provide a basis for intervention.

Official Title
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Early Warning Model Construction on Cognition, Resistance and Using Risk of the New Psychoactive Substances in Adolescents Based on Behavioral Expression of Addiction Susceptibility Genes and Adverse Childhood Experience

Conditions
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Drug Addiction

Intervention / Treatment
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* Other: Questionnaires


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adolescents aged 14-35 (including 14,35 years old) Agree to participate in the studies Exclusion Criteria: Be diagnosed with psychological or mental illness People that are unconscious, emotionally unstable, or unable to communicate normally Patients with severe diseases

Ages Eligible for Study
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Minimum Age: 14 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Investigation Team<br>Questionnaires assessed adolescents aged 14-35 years old (including 14,25 years old) who agreed to participate in the study | Other: Questionnaires<br>* Participants will be asked to complete the questionnaire including general demographic information, the cognition, resistance and use of NPS as well as the behavioral expression of addiction susceptibility genes and adverse childhood experience.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the cognition of NPS | knowledge questionnaire of drug types and risk awareness of drug use will be investigated to know the degree of cognition to NPS | Baseline | 
| the resistance of NPS | the drug refusal self-efficacy scale and the drug use permissive attitude will be used to measure the the resistance of NPS | Baseline | 
| the use of NPS | there will be some questions to investigate the drug use conditions | Baseline | 
| Adverse Childhood Experience | the Chinese version of Adverse Childhood Experience Scale with 10 items will be used to measure the adverse childhood experience | Baseline | 
| hedonic hunger | the Power of Food Scale with 15 items will be used to measure hedonic hunger | Baseline | 
| sensation seeking personality | the Brief Sensation Seeking Scale for Chinese with 8 items will be used to measure sensation seeking personality | Baseline | 
| prosocial behavior | the Prosocial Tendencies Measure with 26 items will be used to measure prosocial behavior | Baseline | 
| externalizing behavior | 17 items of aggressive behavior and 15 items of rule-breaking behavior from the Chinese Version of Achenbach Youth Self-Report-2001 Version will be used to measure adolescents' degree of externalizing behavior | Baseline | 
| sleep quality | the Pittsburgh Sleep Quality Index with 9 items will be used to measure adolescents' sleep quality | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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risk prediction model, NPS, addiction susceptibility genes, adverse childhood experience, adolescents