Healing Abutment Materials on Matrix Metalloproteinase-8 Level in Peri-implant Crevicular Fluid

Study Overview
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Brief Summary
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Numerous materials are nowadays used in the fabrication of healing abutments to be used for dental implants. soft tissue response to different healing abutment materials is still to be unraveled. the Aim of this study is to compare the soft tissue response to titanium stock healing abutments to customized composite healing abutments through assessing the level of matrix metalloproteinase-8 in the peri-implant crevicular fluid

Official Title
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Effect of Two Different Healing Abutment Materials on Matrix Metalloproteinase-8 Level in Peri-implant Crevicular Fluid (a Randomised Clinical Trial)

Conditions
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Dental Implants

Intervention / Treatment
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* Other: Stock healing abutments
* Other: Compoiste healing abutments


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with no systemic and/or oral health disease absence of any lesions in the oral cavity wide band of keratinized tissue more than 1mm at implant site Exclusion Criteria: smoking more than 20 cigarettes per day localized radiation therapy of the oral cavity, antitumor chemotherapy, liver diseases, blood diseases, kidney diseases, immunosuppressed patients, patients taking corticosteroids, pregnancy, inflammatory and autoimmune diseases of the oral cavity

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Test group<br> | Other: Compoiste healing abutments<br>* 2ND stage surgery will be performed and composite healing abutment were placed<br>|
| Active Comparator: Control group<br> | Other: Stock healing abutments<br>* 2ND stage surgery will be performed and stock healing abutment were placed<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in MMP8 levels | Measuring MMP-8 level around composite and titanium healing abutments with ELISA kit | at 2 weeks and 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in gingival condition | Modified gingival index was used to assess gingival condition The MGI uses a rating score between 0 and 4 0 = absence of inflammation = mild inflammation = mild inflammation = moderate inflmmation = severe inflammation | at 2 weeks and 4 weeks | 
| Change in gingival bleeding | Bleeding index will be recorded as present or absent | at 2 weeks and 4 weeks | 
| Change in plaque accumulation | Plaque index 0: No plaque is in the area adjacent to the gingiva. Plaque index 1: There is a plaque in the form of a thin film on the gingival margin. Plaque index 2: There is a visible plaque in the gingival pocket and gingival margin. Plaque index 3: There is a dense plaque in the gingival pocket and on the gingival margin. | at 2 weeks and 4 weeks |