Psychological and Pain Factors in Knee Osteoarthritis

Study Overview
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Brief Summary
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This study aims to determine if baseline measures of psychology and pain sensitivity can predict changes in physical function at 1 year in patients with knee osteoarthritis.

Official Title
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Associations Between Psychological Factors, Pain Sensitivity, and Physical Function in Knee Osteoarthritis: a One-year Follow up Study

Conditions
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Knee Osteoarthritis

Intervention / Treatment
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* Diagnostic Test: WOMAC pain subscale


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Physician diagnosis of knee OA based on clinical and radiographic ACR criteria Pain in or around the knee on most days of the past month Aged 40 years or above Ambulatory with or without walking aid Exclusion Criteria: Inflammatory arthritis (rheumatoid arthritis, lupus, etc.) Recent knee injury or surgery (past 3 months) Severe comorbidity likely to prevent study completion (dementia, terminal illness) inability to comply with study procedures or follow up

Ages Eligible for Study
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Minimum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Knee Osteoarthritis<br>Patients with physician-diagnosed knee osteoarthritis | Diagnostic Test: WOMAC pain subscale<br>* The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale is a self-reported questionnaire that is used to measure pain in people with osteoarthritis (OA). The subscale consists of five items that ask about the intensity, frequency, and duration of pain in the hip and knee joints. The WOMAC Pain Subscale has been shown to be a reliable and valid measure of pain in people with OA. It has been used in a number of clinical trials and is considered to be a standard measure of pain in OA. The WOMAC Pain Subscale is scored on a scale of 0 to 4, with 0 indicating no pain and 4 indicating severe pain. The total score for the subscale is the sum of the scores for the five items. A higher score indicates more pain.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Physical Function from Baseline to 1 year (WOMAC) | Assessed using the WOMAC physical function subscale (0-68 scale, higher = worse function) | Change from baseline at 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain Catastrophizing Scale | Assessed using the Pain Catastrophizing Scale (0-52 scale, higher = higher catastrophizing) | Change from baseline at 1 year | 
| Kinesiophobia | Assessed using the Tampa Scale of Kinesiophobia (17-68 scale, higher = higher kinesiophobia) | Change from baseline at 1 year | 
| Change in Sleep Quality from Baseline to 1 year (Pittsburgh Sleep Quality Index) | Assessed using the Pittsburgh Sleep Quality Index (0-21 scale, higher = worse sleep quality) | Change from baseline at 1 year | 
| Change in Pain Self-efficacy from Baseline to 1 year (Pain Self-Efficacy Questionnaire) | Assessed using the Pain Self-Efficacy Questionnaire (0-60 scale, higher = stronger self-efficacy beliefs) | Change from baseline at 1 year |