Throid Function and Liver Failure

Study Overview
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Brief Summary
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Liver plays an important role in the metabolism of thyroid hormones, as it is the most important organ in the peripheral conversion of tetraiodothyronine (T4) to triiodothyronine (T3) by Type 1 deiodinase.

Detailed Description
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In clinical terms, cirrhosis is described as are either compensated or decompensated. Decompensation means cirrhosis complicated by one or more of the following features: jaundice, ascites, hepatic encephalopathy (HE), or bleeding varices. Ascites is the usual first sign. Hepatorenal syndrome, hyponatremia, and spontaneous bacterial peritonitis are also features of decompensation, but in these patients, ascites invariably occurs first. Compensated cirrhotic patients have none of these features. The liver plays an important role in the metabolism of thyroid hormones, as it is the most important organ in the peripheral conversion of tetraiodothyronine (T4) to T3 by Type 1 deiodinase. T4 and T3 regulate the basal metabolic rate of all cells, including hepatocytes, and thereby modulate hepatic function. The liver metabolizes the THS and regulates their systemic endocrine effects. Thyroid diseases may perturb liver function; liver disease modulates thyroid hormone metabolism; and a variety of systemic diseases affect both the organs.

Official Title
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Thyoid Dysfucntion; Does it Affect the Short Term Outcome of Heptic Failure Patiens ?

Conditions
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Hepatic Encephalopathy, Hepatic Impairment, Hypothyroidism, Hepatic Failure

Intervention / Treatment
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* Diagnostic Test: hypothroidism
* Diagnostic Test: euothyroid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - hepatic fauiure patients Exclusion Criteria: hypethyroid patients

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hypothroid group<br>throid fuction will be evaluated on admission of hepatic failure patients, and the hypothroid patients will be enroled in this group. | Diagnostic Test: hypothroidism<br>* throid fuction will be evaluated on admission of hepatic failure patients, and the hypothyroid patients will be enroled in this group.<br>|
| Euthroid group<br>throid fuction will be evaluated on admission of hepatic failure patients, and the euothroid patients will be enroled in this group. | Diagnostic Test: euothyroid<br>* throid fuction will be evaluated on admission of hepatic failure patients, and the euothyroid patients will be enroled in this group.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| short termoutcome | mortality dring hospitalstay | 0: 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| complications | suchas renal affection, bleeding tendency ...etc | 0:30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hepatic Failure, Hypothyroidism