linjc16/ctgov huggingface dataset:
Analyzing Clinical Trial Experiences of Colon Cancer Patients

Study Overview
=================
Brief Summary
-----------------
Participation in medical trials usually favors a particular demographic group. But there is limited research available to explain what trial attributes affect the completion of these specific demographic groups. This trial will admit a wide range of data on the clinical trial experience of Colon Cancer patients to determine which factors prevail in limiting a patient's ability to join or finish a trial. It will also try to analyze data from the perspective of different demographic groups to check for recurring trends which might yield insights for the sake of future Colon Cancer patients.

Official Title
-----------------
An In Depth Study Evaluating Patterns in the Colon Cancer Patients Clinical Trials

Conditions
-----------------
Colon Cancer, Colon Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient has been diagnosed with colon cancer Patient has self-identified as planning to enroll in an observational clinical trial Patient is a minimum of 18 years or older Exclusion Criteria: Pregnant or nursing patients Inability to perform regular electronic reporting Patient does not understand, sign, and return consent form

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of colon cancer patients who decide to enroll in a clinical trial |  | 3 months | 
| Rate of patients who remain in a colon cancer clinical trial to trial completion |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Colon Cancer, Colon Disease
Assessment of Automatic Tourniquets for Soldiers During Wartime

Study Overview
=================
Brief Summary
-----------------
The goal of this clinical trial is to compare usability and performance of automatic tourniquets (AUT) and standard mechanical tourniquets (CAT) in healthy adults. The main questions it aims to answer are: Are AUTs effective in occlusion of blood flow Are AUTs easy to use Participants will be asked to place AUT and CAT on their upper limbs and lower limbs (8 applications overall). Following each application, the following parameters will be assessed: Limb blood flow Ease of use Researchers will compare the results of the AUT and CAT to see if AUT is as effective as CAT in blood occlusion, and if AUT is easy to use as the CAT.

Official Title
-----------------
Assessment of Automatic Tourniquets for Soldiers During Wartime as Part of Accelerated Research and Development

Conditions
-----------------
Trauma Injury, Hemorrhage Wound

Intervention / Treatment
-----------------
* Device: Occlusion of blood flow


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: -Soldier in active service or active reserve service. Exclusion Criteria: Muscle disorders Peripheral nerve disorders Skin diseases of the limbs Limb surgery in the past Rickets Hypertension

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Device Feasibility
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Automatic Tourniquet<br>Automatic pneumatic tourniquet | Device: Occlusion of blood flow<br>* Tourniquets will be applied until peripheral blood flow occlusion is achieved. Total intervention time: up to 60 seconds<br>|
| Active Comparator: CAT<br>Combat Application Tourniquet Generation 7 | Device: Occlusion of blood flow<br>* Tourniquets will be applied until peripheral blood flow occlusion is achieved. Total intervention time: up to 60 seconds<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to distal limb arterial occlusion as assessed by Doppler |  | 60 seconds | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety of using automatic tourniquets | Safety issues, specifically peripheral limb numbness will be assessed via questionnaire | Will be assessed via questionnaire up to 5 minutes following the intervention. | 
| Usability of using automatic tourniquets |  | Ease of use will be assessed via questionnaire up to 5 minutes following the intervention. |
Finite Element Role in Zygomaticomaxillary Complex (ZMC) Fracture

Study Overview
=================
Brief Summary
-----------------
A cone beam CT (CBCT) scan of the patient, will be used to create a 3D scanned image of ZMC 3D images will be introduced to finite element (FA)software to evaluate Stresses (MPa) and Life time (cycle) For each model and determine which point of fixation is the best After application this point of fixation on the patient Finite element analysis will be done again to verify the previous results

Official Title
-----------------
Role of Finite Element Analysis for Selection of Single Point Fixation in Zygomaticomaxillary Complex Fracture

Conditions
-----------------
Zygomaticomaxillary Complex Fracture

Intervention / Treatment
-----------------
* Procedure: Zygomaticomaxillary fracture repair


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Fit to general anesthesia (GA) Isolated minimally displaced zygomaticomaxillary complex (ZMC) fracture Exclusion Criteria: absence of other facial trauma, mandibular condylar fracture

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: finite arm<br> | Procedure: Zygomaticomaxillary fracture repair<br>* A cone beam CT (CBCT) scan of the patient will be used to create a 3D scanned image of zygomaticomaxillary complex fracture (ZMC) 3D images will be introduced to finite element (FA) software to evaluate Stresses (MPa), Micromotion (microns), and Life time (cycle) For each model and determine which point of fixation is the best After application this point of fixation on the patient Finite element analysis will be done again to verify the previous results<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stresses by megapascal (MPa) | stress on the plate will be measured for each point of application by finite element (FA) software | immediately after procedure |
Length of Stay Between Early Versus Delayed Oral Postoperative Feeding

Study Overview
=================
Brief Summary
-----------------
Length of stay between early versus delayed oral postoperative feeding after gynecologic surgery under General Anesthesia: Randomized Controlled Trial, single center The goal of this Randomized Controlled Trial is to compare Length of stay between early versus delayed oral postoperative feeding after gynecologic surgery under General Anesthesia. The main question[s] it aims to answer are: Length of stay Complications Participants will randomized (1:1 block randomization ) into Group A or B. The comparison groups are early and delayed postoperative feeding.

Official Title
-----------------
Length of Stay Between Early Versus Delayed Oral Postoperative Feeding After Gynecologic Surgery Under General Anesthesia: Randomized Controlled Trial, Single Center

Conditions
-----------------
Early Feeding

Intervention / Treatment
-----------------
* Other: Food


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Participants undergoing gynecologic surgery with stable vital signs Participants undergoing abdominal gynecologic surgery No evidence of malignancy No underlying disease relating to GI system Not currently having gut obstruction No previous abdominal surgeries aside from appendectomy Previous history of abdominal radiation Exclusion Criteria: Transferred to ICU postoperatively on ETT, NG Participants with immediate complications from operation No informed consent
Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: The participants were randomized (1:1 computerized block randomization) into two groups. One group is early feeding and another is delayed feeding.
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Delayed feeding<br> | Other: Food<br>* Post-operative feeding includes water, liquid diet, soft diet.<br>|
| Experimental: Early feeding<br> | Other: Food<br>* Post-operative feeding includes water, liquid diet, soft diet.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of stay | Length of stay between early versus delayed oral postoperative feeding | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complications | Complications occur during postoperative feeding between two groups | 12 months |
The Effects of Playful Pathways

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate infants ages 0-6 months of age before and after an 8 week developmental and educational caregiver and baby interactive program as well as 3 month following the conclusion of the program. The researchers aim to screen and identify developmental delays and the effects of the 8 week program on gross motor development as well as explore parent perceptions of the program. The aim of this study is to assess the physical, social, and emotional outcomes of an interactive group program for infants 0-6 months and their families/caregiver.

Official Title
-----------------
The Effects of Playful Pathways, a Play-Based Developmentally Focused Group Program, and How it Affects Caregivers' Health Literacy and Self-Efficacy and Influences Outcomes for Infants

Conditions
-----------------
Gross Motor Development Delay

Intervention / Treatment
-----------------
* Other: Gross motor development group session


Participation Criteria
=================
Eligibility Criteria
-----------------
All babies typically developing or any diagnosis ages 0 - 6 months; parents/caregivers of babies typically developing or any diagnosis ages 0 - 6 months participating in the intervention. Sample size will be 12 babies ages 0-6 months and their caregivers (1-2 caregivers per baby). Total population 12 infants with up to 30 caregivers. Inclusion criteria: 1. All babies typically developing or any diagnosis ages 0 - 6 months Inclusion criteria for parents/caregivers: At least 18 years of age Able to communicate in and read English Parent/caregiver of baby ages 0 - 6 months who is participating in the program Ability to provide transportation to/from research site(s)
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Gross motor development group session|Group session for gross motor development|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| DAYC-2 | measure of gross motor development | 9/20/23 - 2/20/24 | 
| PHLAT-8 | measure of health literacy | 9/20/23 - 2/20/24 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
INFANT, GROSS MOTOR DEVELOPMENT, GROUP SESSION
Endoscopic Band Ligation for Treating Reflux Disease

Study Overview
=================
Brief Summary
-----------------
GERD is a chronic disease the require different treatment modalities; non have proven long term efficacy with concerns about their safety. The use of band ligation in endoscopy appears safe, repeatable with short learning curve. Placing multiple bands at the Z-line can create a fibrous ring in the distal esophagus acting as a barrier against reflux of gastric content.

Detailed Description
-----------------
The aim of the study is the complete resolution of reflux symptoms without the use of any drug.

Official Title
-----------------
EndoBand: Endoscopic Band Ligation for Treating Reflux Disease (GERD)

Conditions
-----------------
GERD

Intervention / Treatment
-----------------
* Device: Band Ligation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Symptomatic GERD Exclusion Criteria: Any previous surgery for GERD

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Off PPI<br>No symptoms of reflux | Device: Band Ligation<br>* Placing bands in distal esophagus<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Endoscopic Band Ligation for GERD | Resolution of reflux symptoms and stopping proton pump inhibitors. | 1 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
GERD, GastroEsophageal Reflux, Band Ligation, EndoBand
The Impact of Medication Belief on Adherence to Infliximab in Patients With Crohn's Disease

Study Overview
=================
Brief Summary
-----------------
The IFX adherence to CD in China was not high. Medicine concerns may be predictive factor of adherence. By enhancing knowledge and relieving medicine concerns, we may increase patients' adherence to IFX.

Detailed Description
-----------------
Crohn's disease (CD) is an incurable chronic disease that requires long-term treatment. As an anti-tumor necrosis factor (TNF) agent, Infliximab (IFX) is widely used in the treatment of Crohn's disease, while the adherence is not high. The purpose of this study was to investigate the adherence to IFX among CD patients in China and evaluate the association between medication belief and IFX adherence.

Official Title
-----------------
The Impact of Medication Belief on Adherence to Infliximab in Patients With Crohn's Disease

Conditions
-----------------
Inflammatory Bowel Diseases

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with a confirmed diagnosis of CD; were treated with infliximab for at least 12 weeks; were informed consent. Exclusion Criteria: The exclusion criteria were received treatment from mental health professionals due to any mental or cognitive impairment; suffered from other serious diseases, such as heart, brain, lung, liver and kidney dysfunction; severe infection, anemia, cachexia or other serious complications were found.

Ages Eligible for Study
-----------------
Minimum Age: 14 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adherence | Adherence was judged by comparing the theoretical infusion times with the actual infusion times in recent 1 year, which was referred to the definition of modified medication possession radio (mMPR) | November 15 to December 28, 2021 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Crohn's disease; adherence; medication concern; infliximab
HCC Staging Modified by Tumor Micronecrosis

Study Overview
=================
Brief Summary
-----------------
Tumor micronecrosis is a pathological feature that reflects malignant biological behavior in hepatocellular carcinoma (HCC). This study aimed to evaluate the prognostic significance of tumor micronecrosis based on the current BCLC and TNM staging systems, and futher improve the performance of the staging models by establishing modified new staging models including tumor micronecrosis.

Official Title
-----------------
Optimizing Hepatocellular Carcinoma Disease Staging Systems by Incorporating Tumor Micronecrosis: A Multi-institutional Retrospective Study

Conditions
-----------------
Hepatocellular Carcinoma

Intervention / Treatment
-----------------
* Behavioral: tumor micronecrosis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: primary and histologically confirmed HCCs patients who underwent curative liver resection Exclusion Criteria: simultaneous presence of other tumors patients who had received preoperative antitumor therapies no available surgical specimens for evaluating micronecrosis status gross tumor necrosis and Nscore = 3

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| micronecrosis(+) group<br>Hepatocellular patients with tumor micronecrosis. | Behavioral: tumor micronecrosis<br>* whether HCC patients have tumor micronecrosis or not<br>|
| micronecrosis(-) group<br>Hepatocellular patients without tumor micronecrosis. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival | the number of months from the date of surgery to the date of the last follow-up visit or time of death. | from date after liver resection until death or last follow-up, whichever came first, assessed up to 72 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disease-free survival | the number of months from the date of surgery to the date of first confirmable recurrence or death | from date after liver resection until recurrence or last follow-up, whichever came first, assessed up to 72 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hepatocellular carcinoma, Tumor micronecrosis, BCLC, TNM, Disease staging
Clinical Efficacy and Safety of Metformin Versus Apple Cider Vinegar (ACV) in Prediabetics

Study Overview
=================
Brief Summary
-----------------
The goal of this clinical trial is to compare efficacy and safety of metformin versus apple cider vinegar in prediabetics . The main question[s] it aims to answer are: Efficacy of metformin versus apple cider vinegar in prediabetics Safety of metformin versus apple cider vinegar in prediabetics Researchers will compare group of prediabetics taking metformin with group of prediabetics taking apple cider vinegar to see if there is difference in safety and efficacy..

Official Title
-----------------
Clinical Efficacy and Safety of Metformin Versus Apple Cider Vinegar (ACV) in Prediabetics

Conditions
-----------------
PreDiabetes

Intervention / Treatment
-----------------
* Drug: Metformin Hydrochloride (HCL)
* Dietary Supplement: Apple cider vinegar


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Males and Female 17-40 years age Body Mass index (BMI) overweight and obese FBS (100-125 mg/dl) HBA1c 5.7% to 6.4% Exclusion Criteria: Concomitant medical problems as established diabetes, hepatic or renal insufficiencies etc. Known allergy or intolerance to metformin or apple cider vinegar

Ages Eligible for Study
-----------------
Minimum Age: 17 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Randomized, open label, prospective, clinical trial
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Metformin<br>Tablet Metformin HCl 500 mg per oral twice daily for 12 weeks | Drug: Metformin Hydrochloride (HCL)<br>* Tab Metformin HCL 500mg twice per day aimed at improving glycemic indices in Prediabetics<br>|
| Active Comparator: Apple cider vinegar<br>Apple Cider Vinegar 15ml per day diluted in 200 ml of water for 12 weeks | Dietary Supplement: Apple cider vinegar<br>* Apple cider vinegar aimed at improving glycemic indices in Prediabetics<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glycated Hemoglobin | Change in glycosylated hemoglobin (HbA1c ) in percent | 12 weeks | 
| Fasting Blood Sugar | Change in fasting blood sugar (FBS) in mg/dL | 12 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Prediabetes, Metformin HCl, Apple cider vinegar