Multiple Breath Washout as a Method for Diagnosing Lung Diseases

Study Overview
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Brief Summary
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Comparison of the new multiple-breath washout method (ndd Medizintechnik Zürich, Trueflow™/Truecheck™) with established methods of lung function diagnostics in patients with idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, asthma and cardiopulmonary healthy individuals.

Detailed Description
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This diagnostic, prospective, clinical study aims to investigate whether the lung function data measured with the EasyOnePro®LAB device correlates with the lung function data from established measurement methods used in routine clinical practice. It is to be investigated whether the EasyOnePro®LAB measurement leads to equivalent results even with a shorter measurement duration due to an improved evaluation. This is relevant for a broader clinical application in the future. It will also be tested whether the fact that the EasyOnePro®LAB measurement can be carried out largely independently of the employee also leads to better reproducibility of the results. To this end, the intra-individual deviations in repeated measurements will be compared between the methods.

Official Title
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Comparison of New Methods of Multiple Breath Washout and Diffusion Capacity Determination (Ndd Medizintechnik Zurich, Trueflow™/Truecheck™) With Established Methods of Lung Function Diagnostics in Patients With Idiopathic Pulmonary Fibrosis, Chronic Obstructive Pulmonary Disease, Asthma and Cardiopulmonary Healthy Individuals

Conditions
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Pulmonary Fibrosis, COPD, Asthma

Intervention / Treatment
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* Diagnostic Test: Multiple-Breath-Washout


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥ 18 years existing consent confirmed diagnosis of one of the following diseases idiopathic pulmonary fibrosis (IPF), confirmed according to the guidelines chronic obstructive pulmonary disease (COPD) with/without emphysema bronchial asthma or patients who are admitted with suspected cardiopulmonary dysfunction (e.g. with unclear dyspnoea) and in whom there is no evidence of cardiopulmonary dysfunction during the diagnostic process (comparison group of healthy patients). Indication for routine performance of the following pulmonary function tests during the current inpatient stay: Ganzkörperplethysmographie (GKP) Diffusionskapazitätsmessung, Single-Breath (DLCO-SB) Exclusion Criteria: Age < 18 years Simultaneous presence of at least two of the following diseases (IPF, COPD/emphysema, asthma, pulmonary arterial hypertension) any medical, psychological or other condition that restricts the patient's ability to give informed consent for voluntary participation in this trial
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cardiopulmonary healthy<br>Patients in whom there is no evidence of cardiopulmonary dysfunction in the course of diagnostics | Diagnostic Test: Multiple-Breath-Washout<br>* One additional diagnostic test is performed using the Multiple-Breath-Washout technology<br>|
| Idiopathic pulmonary fibrosis<br>idiopathic pulmonary fibrosis (IPF), confirmed according to the guidelines | Diagnostic Test: Multiple-Breath-Washout<br>* One additional diagnostic test is performed using the Multiple-Breath-Washout technology<br>|
| Chronic obstructive pulmonary disease<br>Chronic obstructive pulmonary disease (COPD) with/without emphysema | Diagnostic Test: Multiple-Breath-Washout<br>* One additional diagnostic test is performed using the Multiple-Breath-Washout technology<br>|
| Asthma bronchiale<br> | Diagnostic Test: Multiple-Breath-Washout<br>* One additional diagnostic test is performed using the Multiple-Breath-Washout technology<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lung Clearance Index | comparison of the lung clearance index of the different patient groups | immediately ofter the procedure |