Plasma Proteomics in Patients With Postoperative Delirium

Study Overview
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Brief Summary
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Patients undergoing cardiac surgery were recruited. Baseline characteristics of all subjects were collected. The 3-minute Delirium diagnostic Scale (3D-CAM) was used to screen the POD group and non-POD group from the recruited subjects during the first 7 days after surgery. Peripheral blood samples were collected 1 day before surgery and 2 day after surgery. . Plasma was isolated from peripheral blood for subsequent proteomic analysis.

Detailed Description
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Patients undergoing noncardiac surgery were recruited. Baseline characteristics of all subjects were collected. The 3-minute Delirium diagnostic Scale (3D-CAM) was used to screen the POD group and non-POD group from the recruited subjects during the first 7 days after surgery. Peripheral blood samples were collected 1 day before surgery and 2 day after surgery. Plasma was isolated from peripheral blood for subsequent proteomic analysis. To study the characteristics of proteins on a large scale, including protein expression levels, post-translational modifications, protein-protein interactions, etc., so as to obtain a comprehensive understanding of disease occurrence, cell metabolism and other processes at the protein level. Assessment of imbalanced protein expression in peripheral blood using protein profiling may allow us to better understand the pathological changes occurring at the molecular level of POD. Early detection of patients at high risk of POD can optimize perioperative management and promote rapid postoperative recovery.

Official Title
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Serum Biomarkers for Postoperative Delirium Based on Plasma Proteomic Analysis of Elder Patients Undergoing Cardiac Surgery

Conditions
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Postoperative Delirium

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥65 years old, regardless of gender. The patient had clear consciousness and no cognitive impairment, and could cooperate with the investigation and follow-up. The ASA classification is I-Ⅲ. Exclusion Criteria: severe neurological or psychiatric disorders. drug and alcohol abuse. Patients with cognitive impairment caused by various reasons such as neuropsychiatric symptoms. Exclusion criteria included incomplete medical records and failure to complete the postoperative follow-up.

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| POD group<br>According to the occurrence of postoperative delirium, the patients were divided into POD group and non-POD group | |
| non-POD group<br>According to the occurrence of postoperative delirium, the patients were divided into POD group and non-POD group | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences of Quantitative Proteomics between POD and non-POD | Plasma was isolated from peripheral blood for subsequent proteomic analysis. Investigators study the characteristics of proteins at a large-scale level. | 1 day before surgery | 
| Differences of Quantitative Proteomics between POD and non-POD after surgery | Plasma was isolated from peripheral blood for subsequent proteomic analysis. Investigators study the characteristics of proteins at a large-scale level. | 2 day after surgery |