Exploratory Study on Predicting CIDP Patients' Decline During IV Immunoglobulin Treatment Adaptation Feasibility.

Study Overview
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Brief Summary
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ActiCIDP is a monocentric academic study. Patients with Chronic inflammatory demyelinating polyradiculoneuritis may be included on a voluntary basis. The investigators plan to include a group of approximately 40 patients with CIDP. The investigators have planned to assess patient every three months for a year. After each visit, participants will wear Actimyo for one month daily.

Detailed Description
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On each visit, participants will undergo a clinical examination with MRC sum score, a mISS score and a I-RODS score. They will perform few tests 6-minutes walk test (6MWT), a myogrip measurement, and a 9 Hole Peg Test (9HPT) and will answer to some questionaires (mISS, INCAT and PGIC). Actimyo is an innovative device intended to be used in a home-based environment. It is composed of two watch-like sensors, each containing a magneto-inertial sensors that record the linear acceleration, the angular velocity, the magnetic field of the movement in all directions.The two watches can be worn as wristwatch or placed near the ankle.

Official Title
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ActiCIDP : Exploratory Study on the Feasibility of Predicting CIDP Patients' Evolution Decline During Intravenous Immunoglobulins Treatment Adaptation.

Conditions
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Chronic Inflammatory Demyelinating Polyneuropathy

Intervention / Treatment
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* Device: Actimyo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed with CIDP or possible CIDP based on 2021 EAN/PNS criteria2. Treated with IVIg (≤1g/kg/3-8week) Clinically Stable disease for 3 months (according to treating physician opinion). No treatment withdrawal failure within 1 year Age over 18 years Exclusion Criteria: Significant cognitive or communication disorders Surgery or serious traumatic injury ≤ 6 months Non ambulant patient Current participation to a therapeutic trial Anti-myeline antibodies (anti-MAG) positive or nodo-paranodopathy Other autoimmune disease that requires Corticosteroids, IVIg, Plasma Exchange treatment Pregnancy or breastfeeding Any other condition that, according to the investigator, could significantly interfere with patient evaluation or safety.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Actimyo|Participants will wear 2 Actimyos in everyday life. Actimyo is an innovative device intended to be used in a home-based environment. It is composed of two watch-like sensors, each containing a magneto-inertial sensors that record the linear acceleration, the angular velocity, the magnetic field of the movement in all directions.The two watches can be worn as wristwatch or placed near the ankle.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 95th centile of stride velocity | 95th centile of stride velocity obtained with a magneto-inertial sensor (Actimyo) in real-life (meter per second). | 1 year | 
| 50th centile of stride velocity | 50th centile of stride velocity obtained with a magneto-inertial sensor (Actimyo) in real-life (meter per second). | 1 year | 
| 95th centile of stride length | 95th centile of stride length obtained with a magneto-inertial sensor (Actimyo) in real-life (meter). | 1 year | 
| 50th centile of stride length | 50th centile of stride length obtained with a magneto-inertial sensor (Actimyo) in real-life (meter). | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Actimyo, Accelerometry, Daily living