Effect of Ultrasound Combined With Microbubbles on Blood Perfusion in Invasive Breast Cancer

Study Overview
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Brief Summary
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Blood perfusion insufficiency and hypoxia are the main causes of drug resistance to chemotherapy in breast cancer. Increasing blood perfusion can improve drug delivery. The cavitation effect of ultrasound-stimulated microbubbles (USMBs) is known to enhance tumor blood perfusion, so we conducted a prospective human study to investigate the effects of USMBs on hemoperfusion in invasive breast cancer (IBC).

Detailed Description
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patients with IBC were selected from the breast surgery department of our hospital. To induce an enhanced perfusion effect, IBC tumors were treated with SonoVue® microbubbles (MBs) stimulated by ultrasound, with a mechanical index (MI) of 0.2-0.3; 1 mL of SonoVue® MBs were injected at 3.5-min intervals three times for a USMB treatment lasting 10 min. The contrast-enhanced ultrasound (CEUS) parameters peak intensity (PI), area under the curve (AUC), and perfusion area were used to evaluate the changes in blood perfusion.

Official Title
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Effect of Ultrasound Combined With Microbubbles on Blood Perfusion in Invasive Breast Cancer

Conditions
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Invasive Breast Cancer, Cavitation, Perfusion

Intervention / Treatment
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* Procedure: ultrasound combined with microbubbles


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of Invasive Breast Cancer patients scheduled to undergo surgical resection maximum lesion diameter < 4 cm age over 18 years Exclusion Criteria: patients with allergies to SonoVue® patients with severe cardiopulmonary insufficiency, patients who had already received neoadjuvant chemotherapy pregnant women individuals with mental illness Patients who refused to participate in the study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: ultrasound combined with microbubbles|IBC tumors were treated with microbubbles (MBs) stimulated by ultrasound|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in peak intensity (PI) | PI represents the quantitative scale of the highest average concentration of microbubble (MB) in the region of interest (ROI); thus, a larger PI corresponds to a higher concentration of MB in the ROI. | 15 minutes after the USMB procedure | 
| area under the curve (AUC) | AUC represents the total amount of MB passing through the ROI during perfusion; thus, a larger AUC corresponds to greater perfusion in the ROI. | 15 minutes after the USMB procedure | 
| percentage increase in the perfusion area (%) of tumor | The percentage increase in the perfusion area (%) was calculated as follows: (perfusion area after the USMB procedure - perfusion area before the USMB procedure) × 100%/perfusion area before the USMB procedure. The greater percentage increase of perfusion area (%), the more significant the improvement of blood perfusion. | 15 minutes after the USMB procedure | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Contrast-enhanced ultrasound, ultrasound combined with microbubbles, Invasive ductal carcinoma of breast