Financial Incentives and Recruitment to the APT Webstudy

Study Overview
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Brief Summary
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This single-blind, three-arm, randomized, controlled trial will assess the impact of messages and financial incentives on the enrollment of demographically diverse individuals to the Alzheimer Prevention Trials (APT) Webstudy. The APT Webstudy is a novel, online registry that employs quarterly cognitive testing using validated platforms. The APT Webstudy implements fully remote assessments, coordinated by the Alzheimer's Therapeutic Research Institute (ATRI) under USC IRB #HS-17-00746. The purpose of the current study is to test whether we can increase enrollment of diverse individuals into the registry. To do this, we will work with Contra Costa Regional Medical Center (CCRMC), the county public hospital and its affiliated health centers in Contra Costa County, California, to test whether sending messages with and without financial incentives to patients who receive primary care with the health system can increase enrollment to the APT Webstudy. The investigators hypothesize that 1) a certain small financial incentive and an award opportunity based incentive (or a drawing with a prize) will increase enrollment rates of CCHS members into the APT Webstudy relative to the control group. The investigators further hypothesize that the award opportunity incentive will increase the enrollment rate of CCRMC patients into the APT Webstudy more than a certain financial incentive with the same expected value.

Official Title
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A Randomized Trial of Financial Incentives for the Recruitment of County Health System Patients to the Alzheimer Prevention Trials (APT) Webstudy

Conditions
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Alzheimer Disease, Dementia, Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease

Intervention / Treatment
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* Behavioral: Financial Incentives
* Behavioral: Message


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: To be eligible to participate in this study, an individual must meet all of the following criteria: Patients empaneled at Contra Costa Regional Medical Center (CCRMC), the county public hospital and its affiliated health centers. Age 50 or older Literate in either English or Spanish Exclusion Criteria: Below age 50 Documentation of prior dementia diagnosis

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Messaging Only<br>16,000 participants will be randomized to Arm 1 where no monetary incentive is offered. | Behavioral: Message<br>* Message inviting participant to enroll<br>|
| Experimental: Small Incentive<br>16,000 participants will be randomized to Arm 2 where a small one-time monetary incentive is offered. | Behavioral: Financial Incentives<br>* Small financial incentive or prize incentive<br>|
| Experimental: Prize Incentive<br>16,000 participants will be randomized to Arm 3 where an opportunity based incentive (or a drawing with a prize) with a single winner will be offered. | Behavioral: Financial Incentives<br>* Small financial incentive or prize incentive<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Enrollment status into the APT Webstudy | APT Webstudy enrollment rate based on completion of at least one of the two APT Webstudy cognitive assessments (Cognitive Function Instrument [CFI] and/or Cogstate Brief Battery). | 2-weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cost per enrollee | Cost to acquire an enrollment | annual | 
| Completion of cognitive assessments within the APT Webstudy | Completion of both APT Webstudy cognitive assessments (Cognitive Function Instrument [CFI] and/or Cogstate Brief Battery). | 2-weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Alzheimer's, Prevention, Observational, Trial-Ready Cohort