linjc16/ctgov huggingface dataset:
The Effect of Obesity in COPD Mechanically Ventilated Patients

Study Overview
=================
Brief Summary
-----------------
Study the relationship between the body mass index and duration of mechanical ventilation & complications in mechanically ventilated COPD patients. Study the effect of obesity on mortality rate of COPD mechanically ventilated patients. Determine prevalence of obesity in mechanically ventilated COPD patients.

Detailed Description
-----------------
Obesity has become a global epidemic with prevalence rising both in developed and developing countries. The percentage of patients with obesity in the intensive care unit (ICU) can be expected to increase concomitantly or even more since obesity increases the risk for a more severe disease course with more need for ICU admission and mechanical ventilation . Obesity, especially abdominal obesity (android fat distribution) and severe obesity, results in altered respiratory anatomy and physiology and, therefore, complicated airway management and adapted ventilator settings during mechanical ventilation. Obesity appears to be associated with an increased risk of acute respiratory distress syndrome (ARDS) and infection, mainly pneumonia probably related to an imbalanced production of adipokines. In ventilated patients, obesity increases ICU length of stay and the duration of mechanical ventilation . Obesity is relatively common among individuals with COPD, corresponding to 20%-35% of patients with COPD. Increasing evidence suggests that obesity is a risk factor for impaired quality of life, exercise intolerance, and suboptimal disease control in COPD .

Official Title
-----------------
Effect Of Obesity on The Outcome Of Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients

Conditions
-----------------
Effects of Obesity on COPD Mechanically Ventilated Patients

Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: Adult patients of both genders more than 18 years old admitted at RICU, diagnosed COPD and need mechanical ventilation from August 2023 to August 2024. Exclusion Criteria: patients less than 18 years old. patients who refused to participate in the research. patients with missing data.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Study the effect of obesity on morbidity and mortality rate of COPD mechanically ventilated patients. | Study the relationship between the body mass index and duration of mechanical ventilation & complications in mechanically ventilated COPD patients. | one year |
Alternating Pressure Air Mattress and Pressure Injury Prevalence

Study Overview
=================
Brief Summary
-----------------
explore the correlation of accurate implementation of APAM and pressure injury prevalence

Official Title
-----------------
Explore the Relationship Between Implementation of Alternating Pressure Air Mattress and Pressure Injury Prevalence

Conditions
-----------------
Pressure Injury, Alternating Pressure Air Mattress, Implementation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with pressure injury Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| proportion of full thickness pressure injury | total number of full thickness pressure injuries devided by total number of pressure injuries | 2020/1  2023/8 |
Technical Failure During Colorectal Endoscopic Full Thickness Resection (EFTR): The Through Thick and Thin Study

Study Overview
=================
Brief Summary
-----------------
Among advanced resection techniques, endoscopic full thickness resection (EFTR) allows closure and full-thickness resection by the use of the non-exposed full thickness resection device (FTRD). The study is a retrospective analysis of technical failure occurring during colorectal full-thickness resection. Full thickness resection is a safe and effective procedure for difficult colorectal lesions. However, technical failure can occur and to date there is no evidence about type and clinical consequences in this setting.

Detailed Description
-----------------
The study is a multicentre retrospective study involving centres with experience in advanced colorectal resections. Each centre is invited to submit information about the Centre and to report alle the consecutive cases corresponding to technical failure.

Official Title
-----------------
Technical Failure During Colorectal Endoscopic Full Thickness Resection (EFTR): The Through Thick and Thin Study

Conditions
-----------------
Endoscopic Full Thickness Resection (EFTR), Residual /Recurrent Colorectal Lesion, Full-thickness Resection Device (FTRD), Colorectal Adenoma, Non-lifting Colorectal Lesions, Intraprocedural Complication

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Consecutive colorectal EFTR procedures with technical failure by using OVESCO Full Thickness Resection Device Exclusion Criteria: EFTR performed by exposed techniques and/or devices different from FTRD Patients not able to give informed consent for data collection

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Procedures corresponding to technical failure<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Technical failure rate and classification |  | 2014 - 2022 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Conservative Management of technical failure | Performance of rescue endoscopic resection | 2014-2022 | 
| Clinical success (R0 resection) |  | 2014-2022 | 
| Complication rate |  | 2014-2022 |
SMART TRENDS Study

Study Overview
=================
Brief Summary
-----------------
A multicenter, interventional, feasibility comparison with historical controls

Official Title
-----------------
Acumen HPI Smart Alerts and Smart Trends to Improve Compliance With an Intra-operative Hemodynamic Management Algorithm and Reduce Renal Injury Following Major Elective Noncardiac Surgery.

Conditions
-----------------
Moderate to High-risk Noncardiac Surgery

Intervention / Treatment
-----------------
* Device: Acumen HPI Smart Alerts and Smart Trends Software


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Signed informed consent Age ≥ 18 years ASA Physical Status ≥ 2 Elective noncardiac surgery with expected surgery duration ≥ 3 hours and expected post-operative length of stay of ≥ 3 days Planned monitoring with an arterial catheter General anesthesia with tracheal intubation and positive pressure ventilation Exclusion Criteria: Inability to comply with the study intra-operative hemodynamic management algorithm such as surgeon request for relative hypotension or fluid restriction or avoidance of vasopressors Planned vasopressor or inotrope infusion during surgery Contraindication to intra-arterial blood pressure monitoring Has previously participated in the SMART TRENDS study Serum creatine > 2.0 mg/dL (> 175 μmol/L) or CKD stage > 3A Scheduled for intracranial or cardiac surgery Patient who is known to be pregnant Patients on mechanical circulatory support Emergency surgery Planned beach-chair positioning

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: SMART TRENDS Arm<br>Acumen HPI Smart Alerts and Smart Trends Software Feature to guide hemodynamic management in moderate-to-high-risk noncardiac surgery. | Device: Acumen HPI Smart Alerts and Smart Trends Software<br>* Device: Acumen HPI Smart Alerts and Smart Trends Software The Acumen HPI Smart Alerts and Smart Trends Software provides the clinician with physiological insight into a patient's likelihood of trending toward a hypotensive event. The Acumen HPI Smart Alerts and Smart Trends Software suite is enabled by the minimally invasive Acumen IQ sensor.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HPI Smart Alert | The proportion of HPI Smart Alert prompts displayed resulting in initiation of action within 5 minutes consistent with an intra-operative hemodynamic management algorithm. | From start to end of non-cardiac surgery |
Outcomes and Predictors of Mortality Among Preterm Infants With Neonatal Sepsis

Study Overview
=================
Brief Summary
-----------------
A prospective cross-sectional study of outcomes and predictors of mortality among preterm infants with neonatal sepsis admitted in NICU of Assiut University Children's Hospital

Detailed Description
-----------------
Neonatal sepsis is a clinical syndrome of bacteremia with systemic signs and symptoms of infection in the first 28 days of life. It can also result from viral and fungal invasions of the bloodstream It is one of the events that can occur during neonatal intensive care unit (NICU) admission. It contributes significantly to the morbidity of very preterm (VP: <32 weeks gestational age) and/or very low birthweight (VLBW: <1500 g) infants Sepsis is a major cause of neonatal mortality and neurodevelopmental impairment among neonates which results in death and major disability for 39% of those affected even with timely antibiotic treatment . Globally, it is estimated that more than 1.4 million neonatal deaths annually are the consequence of invasive infections . Infection-specific mortality varies by geographic region and neonatal risk factors like gestational age and body weight . It contributes to nearly 30-50% of neonatal deaths in developing countries . The risk of death is highest in the first 24 h of life when more than half of deaths occur and about three-quarters of all neonatal deaths occur within the first week of life.

Official Title
-----------------
Outcomes and Predictors of Mortality Among Preterm Infants With Neonatal Sepsis Admitted in NICU of Assiut University Children's Hospital

Conditions
-----------------
Neonatal Sepsis

Intervention / Treatment
-----------------
* Other: Prospective study


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All preterm infants (<37 weeks) diagnosed with neonatal sepsis Preterm infants aged 0-28 days Exclusion Criteria: Full term infants (> 37 weeks gestation) -Neonates with congenital anomalies -Neonates diagnosed with metabolic diseases Neonates with birth asphyxia

Ages Eligible for Study
-----------------
Minimum Age: 1 Minute
Maximum Age: 28 Days

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Prospective study|Prospective study of outcomes and predictors of mortality among preterm infants with neonatal sepsis|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mortality among preterm infants with neonatal sepsis | mortality among preterm infants with neonatal sepsis admitted in NICU of Assiut university children's hospital | Baseline |
Dose of Remi in Children

Study Overview
=================
Brief Summary
-----------------
Remimazolam has demonstrated the potential as a valuable medication for procedural sedation and general anesthesia. However, the effective dosage of remimazolam in pediatric patients is still unknown.

Official Title
-----------------
Determination of the 50% and 95% Effective Dose of Remimazolam for Intravenous Anesthesia Induction in Pediatric Patients

Conditions
-----------------
Anesthesia

Intervention / Treatment
-----------------
* Drug: Remimazolam


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age from 3 to 12 years old patients scheduled for surgery under general anesthesia Exclusion Criteria: American Society of Anesthesiologists status >=Ⅲ Body mass index>=28kg/m2 patients who cannot cooperate with intravenous anesthesia induction patients with risk of difficult airway patients who are allergic to benzodiazepines patients with delayed neurologic function

Ages Eligible for Study
-----------------
Minimum Age: 3 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Sequential Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: remimazolam<br>remimazolam is given for anesthesia induction | Drug: Remimazolam<br>* remimazolam is given intravenously<br>* Other names: remimazolam besylate;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| half effective dosage | the dosage by which half of the patients will be sedated | from injection of remimazolam to loss of consciousness, at an average of 5 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 95% effective dosage | the dosage by which 95% of the patients will be sedated | from injection of remimazolam to loss of consciousness, at an average of 5 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
general anesthesia, anesthesia induction, remimazolam
Risk of Osteoporotic Fracture in Home Care Patients in Turkey

Study Overview
=================
Brief Summary
-----------------
This study will assess the incidence of osteoporosis and osteoporotic fracture risk of registered home health patients in the Anatolian side of Istanbul.

Detailed Description
-----------------
After selecting the patients who have been visited by the team in the last 6 months from the patients registered in the home health system, the number of patients required to reflect the population will be determined, and patient files will be selected by randomization. Demographic information, comorbidities, medications, and blood tests will be recorded. FRAX risks of the patients will be calculated, and it will be examined whether they have any previous fracture history and whether they have received treatment for osteoporosis.

Official Title
-----------------
Risk of Osteoporotic Fracture in Home Care Patients in Turkey: A Call for Action

Conditions
-----------------
Osteoporosis, Osteoporosis Risk, Osteoporotic Fractures

Intervention / Treatment
-----------------
* Other: Document review and scanning


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Being registered for home health services Having made a call to home health services in the last 6 months Exclusion Criteria: Patients that have passed away
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Home health care patients<br>Home health patients registered in the Anatolian side of Istanbul | Other: Document review and scanning<br>* Osteoporosis risk and osteoporotic fracture risk will be calculated by examining the patients' files.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Osteoporotic fracture risk of home care patients | Osteoporotic fracture risk of home care patients | 3 months |
Quetiapine in Prevention of Delirium

Study Overview
=================
Brief Summary
-----------------
The aim is to study the effectiveness of Quetiapine in preventing delirium in the elderly patients with multiple risks for delirium.

Official Title
-----------------
Role of Quetiapine in the Prevention of ICU Delirium in Elderly Patients at a High Risk

Conditions
-----------------
Delirium

Intervention / Treatment
-----------------
* Drug: Quetiapine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with anemia Sedated patients Hypotensive patients Immobilized patients Patients with visual or auditory impairment Exclusion Criteria: Patients or guardians refuse to participate Patients diagnosed with delirium Contraindication for delirium

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Quetiapine<br>The patients with multiple risks for delirium will receive 25 mg/day PO | Drug: Quetiapine<br>* The patients will be randomly divided into two equal groups group Q and group C. Randomization will be done by computer-generated number lists and using opaque sealed envelopes.<br>|
| No Intervention: Non pharmacological preventive bundle<br>The patients will only be monitored with application of delirium preventive bundle without pharmacological agent | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quetiapine in preventing delirium | The presence of delirium will be monitored among the patients in the two groups using ICU-Confusion Assessment Method 7 score for delirium where a score of (0-2 = no delirium, 3-5 = mild to moderate delirium and a score >5 = severe delirium) | 2 months |
Comparison of DCB and DES for Severe Calcification of de Novo Lesion in Elderly CHD

Study Overview
=================
Brief Summary
-----------------
The goal of this clinical trial was to compare the effectiveness of drug balloons versus drug-coated stents in calcified lesions in elderly coronary artery disease. The main question it aims to answer is whether the application of DCB is non-inferior to DES for in situ large vessel calcified lesions in the elderly coronary arteries. And to develop a method to precisely identify the nature and extent of calcified lesions and to rationalize the choice of pretreatment.

Official Title
-----------------
Comparison of Drug-coated Balloon and Drug-eluting Stent for Severe Calcification of de Novo Lesion in Elderly Coronary Heart Disease

Conditions
-----------------
Coronary Artery Disease

Intervention / Treatment
-----------------
* Device: DES
* Device: DCB


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1. older than 60 years of age. 2. meeting the indications for coronary intervention. 3. IVUS examination suggests severe calcified lesions (calcification angle > 270° at the target lesion) or OCT examination suggests severe calcified lesions (calcification angle > 180° and/or length > 5 mm and/or thickness > 0.5 mm); 4. Target lesion vessel diameter > 2.5 mm Exclusion Criteria: 1. inability to provide written informed consent. 2. unable to administer antiplatelet agents and anticoagulant therapy; have allergies to heparin, contrast agents, etc. 3. the subject is participating in another uncompleted clinical trial 4. life expectancy <1 year. 5. non-in situ vascular lesions. 6. cardiogenic shock. 7. Patients with hemodynamic instability

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: DCB Group<br>Implantation of drug-coated balloons in patients with satisfactory pretreatment | Device: DCB<br>* Drug-coated balloon with paclitaxel as drug coating<br>|
| Experimental: DES Group<br>Implantation of drug-eluting stents in patients with satisfactory pretreatment | Device: DES<br>* Second-generation drug-eluting stents<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| LLL | Late lumen loss (LLL) of the target lesion segment | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MACE | Cardiovascular death, target vessel revascularization, target vessel non-lethal myocardial infarction | Perioperative period, 30 days, 3 months, 6 months, 12 months after discharge |