Epicardial Adipose Tissue Thickness and the Related Factors in Patients With Ankylosing Spondylitis

Study Overview
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Brief Summary
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The aim of this study was to assess the EATT and the related factors in patients with AS and to compare the results with that of the healthy controls'

Detailed Description
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The aim of this study was to investigate the epicardial adipose tissue thickness (EATT) and the related factors in patients with ankylosing spondylitis (AS) and to compare the results with those of the healthy controls. This cross-sectional study comprised thirty patients diagnosed with AS based on the modified New York criteria. The control group consisted of 31 healthy volunteers. Demographic characteristics were recorded. EATT was measured via transthoracic echocardiography. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Ankylosing Spondylitis Disease Activity Score (ASDAS), Ankylosing Spondylitis Quality of Life (ASQoL), International Physical Activity Questionnaire Short Form (IPAQ-Short Form) were used. Functional capacity assessment was conducted using the six-minute walk test (6MWT).

Official Title
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Epicardial Adipose Tissue Thickness and the Related Factors in Patients With Ankylosing Spondylitis

Conditions
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Ankylosing Spondylitis

Intervention / Treatment
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* Diagnostic Test: epicardial adipose tissue thickness


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Disease duration >1 year, Being ≥18 years AS diagnosis according to modified New York Criteria Exclusion Criteria: Being illiterate, >65 years, History of ischemic heart disease, Cerebrovascular disease, Hypertension, Chronic kidney failure, endocrinopathies like diabetes mellitus, hypothyroidism, Cushing syndrome and primary hyperlipidemia.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Ankylosing spondylitis group<br>Thirty patients with AS according to the modified New York criteria were included in this cross-sectional study. | Diagnostic Test: epicardial adipose tissue thickness<br>* EATT measured via transthoracic echocardiography<br>|
| Healthy volunteers<br>Control group was consisted of 31 healthy volunteers | Diagnostic Test: epicardial adipose tissue thickness<br>* EATT measured via transthoracic echocardiography<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Epicardial adipose tissue thickness | Epicardial adipose tissue thickness is measured via transthoracic echocardiography | through study completion, an average of 5 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bath Ankylosing Spondylitis Disease Activity Index | The index indicates that disease activity of AS patients. Higher scores indicate that higher activity | through study completion, an average of 5 months | 
| Bath Ankylosing Spondylitis Functional Index | The index helps to evaluate disease activity of AS patients. High scores indicate that worse functional status. | through study completion, an average of 5 months | 
| Bath Ankylosing Spondylitis Metrology Index | The index helps to evaluate spinal mobility of AS patients. Higher scores indicate more limited mobility. | through study completion, an average of 5 months | 
| Ankylosing Spondylitis Disease Activity Score | This score is used to evaluate disease activity of AS patients. Higher scores indicate that higher activity. | through study completion, an average of 5 months | 
| Six minute walk test | This test is used to evaluate the patient's functional capacity. In case of low functional capacity, lower scores are observed. Higher scores indicate that higher activity. | through study completion, an average of 5 months | 
| Ankylosing Spondylitis Quality of Life | it is used for evaluate quality of life of AS patients. A lower score indicates better quality of life | through study completion, an average of 5 months | 
| International Physical Activity Questionnaire Short Form | it is used for evaluate patient's physical activity. Scoring a high level of physical activity on the IPAQ means your physical activity levels equate to approximately one hour of activity per day or more at least a moderate intensity activity level. | through study completion, an average of 5 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ankylosing spondylitis, atherosclerosis, epicardial adipose tissue thickness