A Retrospective Study on Extranodal Lymphoma or Lymphoma of Rare Pathological Types

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to retrospectively collect clinical information on patients with extranodal or rare lymphomas, and to explore the best treatment strategy for these lymphomas in the real-world population.

Detailed Description
-----------------
Lymphoma is a highly common malignant tumor in Asia. For specific extra-abdominal sites or rare pathological subtypes of lymphoma, traditional chemotherapy protocols often cannot provide satisfactory results for patients. This study aims to retrospectively collect clinical information on patients with extranodal lymphoma or rare pathological subtype lymphoma, including the distribution of involved sites, clinical and molecular characteristics of different lymphoma subtypes, clinical treatment protocols, and prognosis, to explore the best treatment strategy for these lymphomas in the real-world population.

Official Title
-----------------
A Retrospective Study on Extranodal Lymphoma or Lymphoma of Rare Pathological Types

Conditions
-----------------
Lymphoma, Extranodal Lymphoma, Diffuse Large B Cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Marginal Zone Lymphoma, Mucosa-Associated Lymphoid Tissue Lymphoma, NK/T-Cell Lymphoma, Nasal and Nasal-Type, Intravascular Large B-Cell Lymphoma

Intervention / Treatment
-----------------
* Other: No interventions need to be specified for this study


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥ 18 years (including 18 years old). Patients newly diagnosed with non-Hodgkin lymphoma with extranodal involvement, whether it is primary, secondary, or cannot be determined; Or patients newly diagnosed with non-Hodgkin lymphoma of rare pathological types, including IVLBCL, SMZL, ALCL, AITL, MALTL. Patients who have received systematic clinical treatment. Patients with measurable lesions, at least containing one effective evaluation of efficacy. Exclusion Criteria: Patients who only receive supportive treatment. Patients who cannot obtain effective evaluation data of efficacy.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: No interventions need to be specified for this study|No interventions need to be specified for this study|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall Survival (OS) | Overall Survival (OS) will be defined from the start date of therapy to the date of death from any cause. | Baseline up to data cut-off (up to approximately 1 year) | 
| Progression Free Survival (PFS) | Progression-Free Survival (PFS) will be defined from the date of starting therapy and the date of disease progression, relapse or death from any cause. | Baseline up to data cut-off (up to approximately 1 year) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical characteristics form | Clinical characteristics from data filled into registry forms by physicians and data managers, including but not limited to values of lactate dehydrogenase, clinical stage, performance status, age ≥ 60 years and number and location of extranodal localizations. | Baseline up to data cut-off (up to approximately 1 year) | 
| Biological characteristics form | Biological characteristics from data filled into registry forms by physicians and data managers, such as immunohistochemical differences and genetic mutation characteristics of non-hodgkin´s lymphomas. | Baseline up to data cut-off (up to approximately 1 year) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
LYMPHOMA, EXTRANODAL