Gender Heterogeneity in the Influencing Factors for Cerebral Microbleeds in Acute Ischemic Stroke Patients

Study Overview
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Brief Summary
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The investigators continuously collected data from 482 AIS inpatients at the Neurology Department of Hebei General Hospital. Both demographic and clinical data were collected from the study subjects. Different head magnetic resonance imaging sequences were used to assess the subjects' CMBs, white matter lesions, and old lacunar infarcts (LI). Various statistical methods, including the t-test, χ2 test, and logistic regression, were used to analyze the gender heterogeneity of the influencing factors for CMBs in AIS patients.

Official Title
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Gender Heterogeneity in the Influencing Factors for Cerebral Microbleeds in Acute Ischemic Stroke Patients

Conditions
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Acute Ischemic Stroke

Intervention / Treatment
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* Other: cerebral microbleeds


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aged 18 years and older Must meet the diagnostic criteria for AIS as presented in the Chinese Guidelines for Diagnosis and Treatment of Acute Ischemic Stroke 2014 Must be in good physical condition and have the ability to cooperate with MRI examinations Must have underwent SWI Exclusion Criteria: MRI contraindications present, such as cardiac pacemaker, cardiac stents, or metal implants Head MRI or carotid artery ultrasound suggests the presence of severe stenosis or occlusion in the intracranial or extracranial segments of the cerebral arteries Severe comorbid diseases, such as cardiac, pulmonary, hepatic, and renal insufficiencies

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Comparison of clinical data between AIS patients in CMB and non-CMB groups<br> | |
| without CMBs; with CMBs<br> | Other: cerebral microbleeds<br>* Whether patients with acute ischemic stroke are complicated by cerebral microbleeds<br>|
| male; female<br> | Other: cerebral microbleeds<br>* Whether patients with acute ischemic stroke are complicated by cerebral microbleeds<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of clinical data between AIS patients in CMB and non-CMB groups | Differences in general information between AIS patients in CMB and non-CMB groups | from January 2014 to December 2015 | 
| Comparison of clinical data between male and female AIS patients | Differences in general informationbetween male and female AIS patients | from January 2014 to December 2015 | 
| Comparison of CMB-related characteristics between the male and female AIS patients | Differences in CMB-related characteristics between the male and female AIS patients | from January 2014 to December 2015 | 
| Predictive factor analysis for CMBs in male AIS patients | CMB-related factors in male AIS patients | from January 2014 to December 2015 | 
| Predictive factor analysis for CMBs in female AIS patients | CMB-related factors in female AIS patients | from January 2014 to December 2015 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute ischemic stroke, Cerebral microbleeds, Influencing factors, Gender heterogeneity