Sedation and Postoperative Cognitive Functions

Study Overview
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Brief Summary
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Patients over the age of 65 who underwent elective surgery for a hip fracture and were sedated during spinal anesthesia were included in the study. Patients who were given ketamine and dexmedetomidine for sedation were included in the study. The Mini Mental Status Tests of the patients measured on the first and third days of the operation in the preoperative period were determined from the hospital records and recorded.

Detailed Description
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Patients over the age of 65 who underwent elective surgery for a hip fracture and were sedated during spinal anesthesia were included in the study. The cognitive functions of these patients, which were evaluated by a Mini-Mental Test in the preoperative period, on the first and third days of surgery, were recorded from routine patient follow-up forms. Sedation scores of the patients evaluated by Intraoperative Alertness/Sedation Scale (OAA/S) Observer Evaluation were recorded. Intraoperative hemodynamic data were recorded. The interventions applied to the patient were performed by anesthesiologists who were not involved in the study according to their preferences as part of the routine. The researchers were not involved in any intervention performed on the patient, only the data were recorded.

Official Title
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The Effect of Sedation on Postoperative Cognitive Functions in Patients Operated for Hip Fracture Under Spinal Anesthesia

Conditions
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Cognitive Impairment, Femoral Fractures

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients over the age of 65 who underwent surgery under spinal anesthesia due to hip fracture Volunteered to participate in the study Exclusion Criteria: Patients who are under the age of 65 Patients with known histories of dementia Patients with Alzheimer's disease Patients with central nervous system disease Patients who scored 15 or less according to the Mini Mental Status Test (MMSE) Patients who underwent surgery under general anesthesia Patients who refused to voluntarily participate in the study

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group K<br>Those who have been administered ketamine for perioperative sedation | |
| Group D<br>Those who have been administered dexmedetomidine for perioperative sedation. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mini-Mental Status Test | Evaluation of the effect of sedation with ketamine and dexmedetomidine on postoperative cognitive functions by Mini-Mental Status Test | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| noninvasive mean arterial pressure | The effect of sedation on perioperative hemodynamics. | 6 months | 
| The heart rate | The effect of sedation on perioperative hemodynamics. | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cognitive Impairment, Mini mental status test, Hip fractures, Ketamine, dexmedetomidine