Survey About the Relationship Beetween Allergic Rhinitis and Seasonal EOE Exacerbations

Study Overview
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Brief Summary
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Eosinophilic esophagitis (EoE) is a chronic inflammatory esophagus disease that is presented in patients with a history of recurrent dysphagia. EoE is closely related to other pathologies with an immuno-allergic etiopathogenesis such as atopic dermatitis (AD), IgE-mediated food allergy, allergic rhinitis and bronchial asthma. While the importance of the correlation between diet and food allergy has been largely demonstrated, less is known about the exact role of sensitization to aerollergens in the progression and recrudescence of symptoms. In support of this correlation there is evidence of a seasonal trend in the new diagnoses of EoE, of the possibility of the de-novo onset of the pathology following massive exposure to a specific aeroallergen and the demonstration that the degree of esophageal eosinophilia varies according to the climatic zone and the season of the year. The detailed knowledge of this correlation could clarify some aspects of the etiopathogenesis and natural history of EoE, improve and personalize the clinical-diagnostic management of affected patients and provide new therapeutic targets. Our aim is evaluating the possible existence of a correlation between the recrudescence of dysphagia symptoms and a specific month of the year and/or specific season.

Detailed Description
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Eosinophilic esophagitis (EoE) is a chronic inflammatory esophagus disease that is presented in patients with a history of recurrent dysphagia. EoE is closely related to other pathologies with an immuno-allergic etiopathogenesis such as atopic dermatitis (AD), IgE-mediated food allergy, allergic rhinitis and bronchial asthma. While the importance of the correlation between diet and food allergy has been largely demonstrated, less is known about the exact role of sensitization to aerollergens in the progression and recrudescence of symptoms. In support of this correlation there is evidence of a seasonal trend in the new diagnoses of EoE, of the possibility of the de-novo onset of the pathology following massive exposure to a specific aeroallergen and the demonstration that the degree of esophageal eosinophilia varies according to the climatic zone and the season of the year. The detailed knowledge of this correlation could clarify some aspects of the etiopathogenesis and natural history of EoE, improve and personalize the clinical-diagnostic management of affected patients and provide new therapeutic targets. It is a cross-sectional observational study and the aim is: evaluating the possible existence of a correlation between the recrudescence of dysphagia symptoms and a specific month of the year and/or specific season evaluating whether there is a statistically significant correlation between the anamnestic onset of the disease and the individual patient's sensitization to aeroallergens and the prevalence of respiratory allergy (rhinitis and allergic asthma) in patients with EoE. All the patient should answer a questionnaire about the state of health over the year and according to the various pollen seasons The questionnaire is made up of 18 questions which aim to investigate: anamnestic data (age, weight, height, clinical onset of the pathology); dysphagia symptomatology through modified DSQ (Dysphagia Symptom Questionnaire); rhinitis symptomatology SFAR (Score For Allergic Rhinitis); trend of exacerbations of dysphagia symptoms in the different months of the year. The aforementioned data aim to investigate the rhinitis and dysphagia symptoms of the patients in the last 12 months.

Official Title
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Survey About the Relationship Beetween Allergic Rhinitis and Seasonal EOE Exacerbations: the Role of Respiratory Allergy in the EOE Etiopathogenesis

Conditions
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Eosinophilic Esophagitis, Respiratory Allergy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All the subjects with EOE diagnosis Exclusion Criteria: All the patients without EOE diagnosis

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between the recrudescence of dysphagia symptoms and Seasons | Evaluate the possible correlation between the recrudescence of dysphagia symptoms and a specific month of the year and/or specific season. | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between the anamnestic onset of the disease and the individual patient's sensitization to aeroallergens. | Evaluate whether there is a statistically significant correlation between the anamnestic onset of the disease and the individual patient's sensitization to aeroallergens. | 12 months | 
| Prevalence of respiratory allergy (rhinitis and allergic asthma) in patients with EoE. | Evaluate the prevalence of respiratory allergy (rhinitis and allergic asthma) in patients with EoE. | 12 months |