linjc16/ctgov huggingface dataset:
Tumor Microenvironment

Study Overview
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Brief Summary
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Cancer immunotherapy has the great potential to achieve long-term survival in patients with a solid malignancy. However, the beneficial effect of cancer immunotherapy is seen in only a minority of patients. Mounting evidence suggests that immunosuppressive features in the tumor microenvironment prevent an effective antitumor defense. The aim of the investigators is to comprehensively analyze the cytokine profile and the tumor immune infiltrate in the tumor microenvironment and to investigate its prognostic significance in patients with radically resected lung adenocarcinoma.

Official Title
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Tumor Microenvironment in Lung Adenocarcinoma

Conditions
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Lung Adenocarcinoma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Lung adenocarcinoma Tumor stage IB and II With or without adjuvant therapy Complete surgical resection (R0) No distant metastasis at the time of surgery (M0) Exclusion Criteria: • Second cancer within 5 years

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
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No

Study Plan
=================
How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival | Association of tumor microenvironment with overall survival | From date of surgery until the date of death from any cause assessed up to 100 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrence-free survival | Association of tumor microenvironment with recurrence-free survival | From date of surgery until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months |
Assessment of Left Ventricular Filling Pressure by Applying Artificial Intelligence Algorithms to Left Atrial Speckle-tracking Echocardiography

Study Overview
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Brief Summary
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The goal of this single-center, prospective, observational study is to validate a software package based on an artificial intelligence algorithm for automated non-invasive estimation of LVFP against invasively measured ones by left and right heart catheterization; In addition, the added value of this new automated software to detect increased LVEDP > 15 mm Hg compared to the current ASE/EACVI algorithm for assessing diastolic dysfunction and longitudinal left atrial strain during the reservoir phase will be evaluated.

Official Title
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Valutazione Delle Pressioni di Riempimento Del Ventricolo Sinistro Attraverso l'Impiego di un Software di Intelligenza Artificiale Applicato Alla Stima Dello Strain Atriale Sinistro Con Ecocardiografia Speckletracking: Studio di Validazione Mediante Cateterismo Cardiaco

Conditions
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Heart Failure, Diastolic, Echocardiography

Intervention / Treatment
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* Diagnostic Test: Software algorithm


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ≥ 18 yo, Signed informed consent to be part of this study, No pregnancy, Good acoustic window and patient cooperation to obtain good 2- and 3-dimensional datasets focused on left atrium (LA), Exclusion Criteria: Unwillingness to be part of the study, Patients with poor 2-dimensional imaging quality in ≥ 1 LA segment or lacking of a discernible R-R interval, which might preclude accurate strain measurements, Patients with more than mild mitral valve heart disease, aortic regurgitation, left side valvular prosthesis or mitral valve repair, mitral annulus calcification (≥ 5 mm), Patients with history or presence of atrial fibrillation (AF), supraventricular arrhythmias, ventricular paced rhythm, left bundle branch block (LBBB), Patients taking diuretics or vasodilators (nitrates) on the day of the examination, which could alter loading conditions.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Software algorithm|Validation of a software package based on an artificial intelligence algorithm for automated non-invasive estimation of LVFP against invasively measured ones by left and right heart catheterization|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Left ventricular filling pressure | Invasively measured left ventricular filling pressure by right heart catheterization | During procedure | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
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Transthoracic echocardiography, left ventricular filling pressure, artificial intelligence, right heart catheterization
Triage Survey for Psychiatry Research Eligibility

Study Overview
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Brief Summary
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TRIAGE-Psych is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored psychiatry clinical trials.

Official Title
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Triage Survey for Psychiatry Research Eligibility

Conditions
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Major Depressive Disorder, Borderline Personality Disorder, Generalized Anxiety Disorder

Intervention / Treatment
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* Other: Survey


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participant or Legally Authorized Representative has signed an ICF prior to study-specific procedures being performed. Participant is at least 18 years old. Exclusion Criteria: Participant is pregnant, breast-feeding, or planning to become pregnant. History of a clinically significant illness which in the investigator's opinion may impact participant safety or the ability to analyze study results. Participant represents an acute suicidal risk, as defined as a yes response to ideation on C-SSRS questions 4 or 5, or answer yes to behavior questions within 90 days of screening. Moderate or severe substance use disorder within 90 days prior to screen, according to DSM-5 criteria that in the investigator's opinion could pose undue risk to the participant. Any condition that in the investigator's opinion makes a participant unsuitable for the study. Currently employed by Adams Clinical or a first-degree relative of an employee.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Survey|Participants will be surveyed on demographics, medical history, and current psychiatric symptoms. Vital signs, urine drug screens, and urine pregnancy tests may be collected.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The proportion of participants who are eligible for industry-sponsored clinical trials, as defined as those who go on to screen for a study |  | Up to 52 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The proportion of participants who enroll in industry-sponsored clinical trials |  | Up to 52 weeks | 
| The prevalence of disqualifying comorbid conditions that prevent screening or enrollment in industry-sponsored clinical trials |  | Up to 52 weeks |
Trial Observationnal

Study Overview
=================
Brief Summary
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The aim of this retrospective longitudinal study was to describe a key factor in the prenatal diagnosis of isolated cleft palate on the axial transverse view, in order to provide better understanding, detection and diagnosis of this anomaly.

Detailed Description
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Objective: The study aims to evaluate the role of the posterior hard palate angle in the prenatal diagnosis of cleft palate. Methods: Stored images of the axial transverse view of the fetal secondary palate, obtained at three-level ultrasounds, were used to evaluate the posterior border of the hard palate. The investigators studied the visualization of the posterior nasal spine and the presence of a gap within the hard palate. The investigators also assessed the posterior angle of the hard palate, formed by the posterior borders of the palatine bones next to the most posterior middle point of the palatine bone. The study population comprised 65 consecutive pregnancies of unaffected cases and 17 pregnancies with 24 assessments at different time points, suspected for a cleft palate without cleft lip, including 7 cases of cleft palate, 4 cases of high arched palate and 6 false positive cases.

Official Title
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Diagnosis of Fetal Isolated Cleft Palate Using Assessment of the Posterior Hard Palate Angle

Conditions
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Fetal Anomaly, Ultrasound

Intervention / Treatment
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* Diagnostic Test: Posterior angle of the hard palate


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: - all patients suspected for a cleft palate without cleft lip referred to the Multidisciplinary Center for Prenatal Diagnosis in Poitiers (France) between January 2019 and January 2023. Exclusion Criteria for the control group: major congenital anomalies or chromosomal aberration, premature rupture of the membranes, fetal demise, patients aged under 18 years. If the available images did not allow the evaluation of the hard palate, the case was excluded from further consideration.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| affected<br>patiente suspected for a cleft palate without cleft lip | Diagnostic Test: Posterior angle of the hard palate<br>* Fetal ultrasound<br>* Other names: Gap within the hard palate and the no visualization of the nasal spine;|
| control<br>unaffected cases | Diagnostic Test: Posterior angle of the hard palate<br>* Fetal ultrasound<br>* Other names: Gap within the hard palate and the no visualization of the nasal spine;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of cleft palate without cleft lip | Presence of cleft palate without cleft lip in postnatal exam | derivery |
Development of Brief Positive Affect Treatment (PAT) for Caregivers of Patients With Advanced Cancer

Study Overview
=================
Brief Summary
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To learn more about the experience and wellbeing of people who provide care for cancer patients.

Detailed Description
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OBJECTIVES Primary Objectives: The primary objective of this proposal is to identify relevant themes and content essential to adapt PAT to a caregiving in advanced cancer context (PAT-C) and develop a Brief (5-session) version of PAT-C. Findings from this study are essential to inform future RCTs to test the feasibility, efficacy, dose and explore potential mediators of treatment outcomes of this intervention. Secondary Objectives: The secondary objective is to characterize psychosocial distress and psychosocial health of caregivers in the supportive care clinic. This data will be essential to inform appropriateness of the supportive care clinic as a potential site for future RCTs (i.e., determine if there are enough caregivers in this clinic who might benefit from this specific supportive care strategy).

Official Title
-----------------
Development of Brief Positive Affect Treatment (PAT) for Caregivers of Patients With Advanced Cancer

Conditions
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Cancer

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Provision of signed and dated informed consent form Stated willingness to comply with all study procedures and availability for the duration of the study Males and female adults ≥18 years Able to read and speak English Caregiver of a patient diagnosed with stage IV solid malignancy, with whom they have been residing for >6 months Access to necessary resources for participating in a technology-based intervention (i.e., telephone, internet access) Exclusion Criteria: Current participation in consistent (self-defined) psychotherapy Caregivers who are considered part of a vulnerable population (i.e. cognitively impaired (self-reported or patient-reported), pregnant, military personnel) will not be eligible.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of Life questionnaire (Qol) |  | through completion of study; approximately 1 month |
Use of Osteopathic Manipulative Treatment for Non-musculoskeletal Conditions

Study Overview
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Brief Summary
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The goal of this observational study is to learn how clinicians use osteopathic manipulative treatment (OMT) for their patients who have problems only related to their muscles, bones, and joints (ie, musculoskeletal problems) compared to patients whose problems involve other body systems (eg, infections, breathing, bowel function). The main questions it aims to answer are: What percentage of patients receiving OMT have a non-musculoskeletal problem? Is there a difference in the OMT techniques when the patient's problems include a non-musculoskeletal problem compared to patients with only musculoskeletal problems? Surveys will be completed by the clinicians about 20 unique adult (age 18 or older) patients who have received OMT.

Official Title
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Use of Osteopathic Manipulative Treatment for Non-Musculoskeletal Conditions: A DO-Touch.NET Card Study

Conditions
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Manipulation, Osteopathic

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients receiving osteopathic manipulative treatment from a participating treatment provider Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
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No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Type of chief complaint | Multiple choice question: Do this patient's chief complaints include musculoskeletal complaints only, non-musculoskeletal complaints only, or both musculoskeletal and non-musculoskeletal complaints? | 24 hours | 
| Osteopathic manipulative treatment techniques | Multiple choice question (multiple answers): What OMT techniques did you use to treat this patient's somatic dysfunction? (list of 12 OMT technique categories) | 24 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
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Musculoskeletal Diseases, Non-Musculoskeletal Diseases, Osteopathic Manipulative Treatment
Moesin Expression in Clear Cell Renal Cell Carcinoma

Study Overview
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Brief Summary
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Renal cell carcinoma (RCC) is the most frequently occurring primary renal neoplasm. There are several histological variants of RCC that are associated with variable prognostic outcomes. Epithelial-mesenchymal transition (EMT) is a phenomenon in which the epithelial cells acquire some mesenchymal criteria as enhanced invasive potential. There are several cell surface molecules that are implicated in EMT. Moesin is one of these molecules that is involved in EMT, which is associated with enhanced invasive potential and poor prognosis. Targeting Moesin by novel therapeutic agents may prevent EMT and improve prognosis of patients with RCC.

Official Title
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Expression and Distribution of Membrane-Organizing Extension Spike Protein (Moesin/ MSN) is Associated With Epithelial-Mesenchymal Transition in Clear Cell Renal Cell Carcinoma.

Conditions
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Renal Cell Carcinoma

Intervention / Treatment
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* Genetic: Immunohistochemical detection of Moesin in Clear cell Renal Cell Carcinoma


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: All cases of ccRCC. Tissue blocks with material adequate for immunohistochemical evaluation. All cases with accessible clinical data. Exclusion Criteria: Cases of renal neoplasms other than ccRCC. Patients who received preoperative chemotherapy or radiotherapy. Patients with ccRCC who were diagnosed by tru-cut biopsies only and didn't undergo radical operations. Cases with insufficient/destructed material. Patients with inadequate clinical data.
Sexes Eligible for Study
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All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Genetic: Immunohistochemical detection of Moesin in Clear cell Renal Cell Carcinoma|Formalin-fixed paraffin-embedded renal cell carcinoma tissue blocks will be sectioned and immunohistochemically stained by anti moesin antibody.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detection of Moesin in renal cell carcinoma | different levels of moesin expression will be correlated with some tumor characteristics as patients' ages, sexes, tumor site, tumor grades, stages and nodal statuses. | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
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Renal Cell Carcinoma, Moesin, Epithelial-Mesenchymal Transition
Frailty Trajectories and Their Association With Health Outcomes

Study Overview
=================
Brief Summary
-----------------
Frailty is common in gastric cancer survivors and seriously affects their prognosis. Multiple longitudinal follow-up assessment of frailty could provide a better understanding of the frailty change of individuals. Our aims were to identify the longitudinal trajectories of frailty and estimate their association with health outcomes in elderly gastric cancer survivors.

Detailed Description
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Our study suggested the significant heterogeneity in frailty trajectories among elderly gastric cancer survivors, and that different trajectories had different effects on health outcomes. Our results infer the necessity for prevention strategies in elderly gastric cancer survivors to manage heterogeneous frailty trajectories.

Official Title
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Exploration of Frailty Trajectories and Their Association With Health Outcomes in Elderly Gastric Cancer Survivors Undergoing Radical Gastrectomy: a Prospective Longitudinal Observation Study

Conditions
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Frailty Syndrome

Intervention / Treatment
-----------------
* Other: observation


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: diagnosed with gastric cancer by endoscopy or pathology; received radical gastrectomy the first time; aged ≥60 years; been able to communicate simply in writing and verbal; completed the data collection of all follow-up points. Exclusion Criteria: received radiotherapy or chemotherapy before surgery; had other sites of malignant tumors; complicated with severe heart, liver, lung and renal insufficiency; had physical disability.

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| improving frailty<br>Class 1 | Other: observation<br>* observation<br>|
| maintaining frailty<br>Class 2 | Other: observation<br>* observation<br>|
| deteriorating frailty<br>Class 3 | Other: observation<br>* observation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| quality of life (QOL) | used EORTC QLQ-STO22 to assess. | at 1-year after surgery | 
| disability | used Elderly Disability Assessment Scale to assess. | at 1-year after surgery | 
| 1-year hospital readmissions | captured from medical records. | at 1-year after surgery | 
| total costs | captured from medical records. | at 1-year after surgery |
Utilization of Airway Stabilizing Rod

Study Overview
=================
Brief Summary
-----------------
The pediatric airway is known to be more challenging than the adult airway when performing endotracheal intubation. When a patient cannot be ventilated and/or intubated, the guidelines for airway management dictate that a laryngeal mask airway (LMA) be used as a rescue device to oxygenate and ventilate the patient. While an excellent device the LMA is seen as temporary and ultimately needs to be replaced by an endotracheal tube (ETT).

Detailed Description
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The objective is to study this device in patients with difficult airway to assess the success rate and time to intubation for placing an endotracheal tube using this device.

Official Title
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Utilization of Airway Stabilizing Rod to Assist With LMA Guided Fiberoptic Intubation in Children

Conditions
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Airway Complication of Anesthesia

Intervention / Treatment
-----------------
* Device: Time to Intubation using FASTER device


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: Ages 5-18 years Requiring intubation Known difficult airway LMA placement possible Exclusion Criteria: Known normal airway Procedure not requiring endotracheal intubation Parental refusal Patient dissent

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
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No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Interventional Model Description: Testing of device for success during endotracheal intubation
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Time to intubation using FASTER device<br>Time from fiberoptic placement into airway to documentation of end-tidal carbon dioxide waveform through the endotracheal tube. | Device: Time to Intubation using FASTER device<br>* Time from fiberoptic placement onto airway to documentation of end-tidal carbon dioxide waveform through the endotracheal tube.<br>* Other names: FASTER;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall time in the airway | Time from fiberoptic placement onto airway to documentation of end-tidal carbon dioxide waveform through the endotracheal tube. | 5 minutes | 
| Total time to intubation | Time from movement of the device to documentation of end-tidal carbon dioxide waveform through the endotracheal tube. | 3 minutes |