Functional Instability in Patients Suffering From Collagen Disease and Joint Hypermobility

Study Overview
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Brief Summary
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A joint is considered hypermobile when it has a greater range of motion than normal for a given age, ethnicity or gender. Many people have asymptomatic hyperlaxity in multiple joints, a condition called Generalized Joint Hypermobility (GJH). Conversely, hyperlaxity can be symptomatic, a condition that has been defined Joint Hypermobility Syndrome - JHS. Diagnosis of JHS is commonly performed by applying the revised Brighton criteria. Based on these criteria, an individual is diagnosed with JHS with a Beighton score >/= 4/9, and arthralgia for 3 or more months in 4 or more joints (major criteria). The dynamic body balance test (i.e. the stability test with multiple single-leg jumps) can provide information regarding the effectiveness of the feedforward and feedback mechanisms in correcting the postural deviations necessary to achieve successful performance during daily and sporting activities. Such assessment may also be useful to demonstrate deficiencies in balance, especially in young patients with increased physical activity. The aim of this study is to examine the postural balance of individuals with JHS by performing stability tests in monopodalic and bipodalic stance with the Delos Postural Proprioceptive System

Official Title
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Evaluation of Functional Instability Using the Delos Proprioceptive System in Patients Suffering From Collagen Disease and Joint Hypermobility

Conditions
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Hypermobility Syndrome, Danlos Disease, Ehlers, Collagen Diseases, Joint Hypermobility, Laxity of Ligament

Intervention / Treatment
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* Diagnostic Test: Clinical tests and balance evaluation using the Delos Proprioceptive System


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with moderate (Beighton-Horan Joint Mobility Index score from 3 to 4) or severe (Beighton-Horan Joint Mobility Index score from 5 to 9) joints hyperlaxity at the clinical evaluation Exclusion Criteria: Obesity (BMI > 25) and weight > 90 kg Practice of competitive sport Orthopedic (complex surgery of the spine and lower limbs), neurological (spasticity, stroke), and oncological comorbidities Orthostatic / walking inability Absence of joints hyperlaxity at the clinical evaluation (Beighton-Horan Joint Mobility Index score from 0 to 2)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Joint Hypermobility Syndrome<br>Patients suffering from Joint Hypermobility Syndrome with a moderate/severe degree of joint hypermobility (Beighton-Horan Joint Mobility Index score 3-9) | Diagnostic Test: Clinical tests and balance evaluation using the Delos Proprioceptive System<br>* Each patient is evaluated using clinical tests (Time up and go test, 6 minutes walking test), scales (BORG scale, Beighton score), and the ''Delos Proprioceptive System'' to assess balance control and proprioception with bipodalic and monopodalic tests.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessing proprioception and postural control | Assessing proprioception and postural control using the Delos Proprioceptive System to obtain static and dynamic stability indicators | baseline |