Distinct Metastatic Phenotypes Between Early-onset and Late-onset Colorectal Cancer

Study Overview
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Brief Summary
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The clinical and pathological features of early-onset colorectal cancer (EOCRC) differ from those of late-onset colorectal cancer (LOCRC). Our research aims to thoroughly elucidate the distinctions between them by analyzing clinical prognosis, metastatic patterns, gene expression, and genomic mutation profiles. Our deliberation will uncover latent strategies for personalized therapeutic of both EOCRC and LOCRC.

Official Title
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Integrated Analysis of Multi-center Cohorts and Bulk RNA-sequencing Data Reveal Distinct Metastatic Phenotypes Between Early-onset and Late-onset Colorectal Cancer

Conditions
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Early-onset Colorectal Cancer, Late-onset Colorectal Cancer

Intervention / Treatment
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* Other: standardized treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The initial diagnosis of colonoscopy and pathology belongs to colorectal cancer; Patients should sign an informed consent form after fully understanding the purpose, procedures and potential risks of the study, indicating their voluntary participation in the research. Exclusion Criteria: Patients with obvious local or systemic severe infection; Acute abdomen: intestinal obstruction, peritonitis, intestinal perforation; Have a systemic underlying disease that has not been controlled, or is unstable; Patients with poor physical fitness or serious other organic diseases who cannot tolerate anesthesia and surgery; Women during pregnancy, perinatal and lactation; Patients with severe mental disorders (such as schizophrenia, bipolar disorder, etc.) or patients who are mentally incapable or unable to understand the requirements for participation in the study.

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| EOCRC<br>Patients aged<50 with colorectal cancer between 2008 and 2018 in Fudan university Shanghai cancer center. | Other: standardized treatment<br>* Patients enrolled in these 2 cohorts all received standardized treatment of colorectal cancer.<br>|
| IOCRC<br>Patients aged between 50 to 70 with colorectal cancer between 2008 and 2018 in Fudan university Shanghai cancer center. | Other: standardized treatment<br>* Patients enrolled in these 2 cohorts all received standardized treatment of colorectal cancer.<br>|
| LOCRC<br>Patients aged between≥70 with colorectal cancer between 2008 and 2018 in Fudan university Shanghai cancer center. | Other: standardized treatment<br>* Patients enrolled in these 2 cohorts all received standardized treatment of colorectal cancer.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| OS | overall survival | 5 years after intervention |