EFFECTS OF LASER PUNCTURE VERSUS ULTRAVIOLET ON POLYCYSTIC OVARIAN WOMEN

Study Overview
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Brief Summary
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Obese women with polycystic ovarian syndrome aged between 25 and 35 years old will be divided into three groups. For three months, group (A) will receive laser puncture (3 sessions per week), along with a metformin supplementation, group (B) will receive ultraviolet radiation (3 sessions per week), along with a metformin supplementation, while group (C) will receive only metformin supplementation. The follicular size will be measured using ultrasound, while, female sex hormones, and serum 25-hydroxyvitamin D levels will bel evaluated using blood analysis

Detailed Description
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Obese women with polycystic ovarian syndrome aged between 25 and 35 years old will be divided into three groups. For three months, group (A) will receive laser puncture (3 sessions per week), along with a metformin supplementation, group (B) will receive ultraviolet radiation (3 sessions per week), along with a metformin supplementation, while group (C) will receive only metformin supplementation. The follicular size will be measured using ultrasound, while, female sex hormones, and serum 25-hydroxyvitamin D levels will bel evaluated using blood analysis

Official Title
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EFFECTS OF LASER PUNCTURE VERSUS ULTRAVIOLET ON POLYCYSTIC OVARIAN WOMEN

Conditions
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Polycystic Ovary Syndrome

Intervention / Treatment
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* Device: aser puncture
* Device: ultraviolet radiatio
* Drug: Metformin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Obese nulli gravid PCOS women BMI 30-40 kg/m2 Exclusion Criteria: hyperprolactinemia BMI > 40 kg/m2 Endocrinological disorders such as thyroid disease, Cushing's syndrome, Coagulopathy Recent use of oral contraceptive pills Recent use of any photosensitizing medications, such as aspirin, tetracycline, chlorothiazide, or psoralen suspicious of neoplasms

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: laser puncture group<br>gallium Arsenide infrared (GaAlAs) laser, using a wavelength at 904nm with a Maximum power output is 150 mW and a power density at 0.417 W/cm2 as well as an energy density of 4 J/cm2 will be employed for 2 minutes on specific acupuncture points | Device: aser puncture<br>* laser puncture (3 sessions per week)<br>Drug: Metformin<br>* for 3 months<br>|
| Active Comparator: Ultraviolet treatment group<br>The therapist will place the UV arc lamp at a height of 60 to 80 cm above the lower abdomen region, perpendicular to the skin. Each woman's lamp will be switched on and given an individual timer by the minimum effective dose | Device: ultraviolet radiatio<br>* ultraviolet radiation (3 sessions per week)<br>Drug: Metformin<br>* for 3 months<br>|
| Active Comparator: Metformin only group<br> | Drug: Metformin<br>* for 3 months<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| LH/FSH ratio | LH/FSH ratio measured in venous sample on day 3 of the menstrual cycle | 1 month after treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum 25-hydroxyvitamin D | 25-hydroxyvitamin D measured in venous sample | 1 month after treatment |