Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders

Study Overview
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Brief Summary
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Damages in frontal area present in neurodegenerative disease (frontotemporal degeneration, frontal variant of Alzheimer disease) and in psychiatric disease (bipolar disorder) can affect behavior and cognition including social cognition. Symptoms vary both quantitatively and qualitatively from disease to another and from person to person. It cannot be completely excluded that in some cases, factors of susceptibility such as premorbid personality traits lead to frontal fragility. The study will assess the relationship between premorbid profile using NEO-PI 3 inventory and cognitive and behavioral/psychobehavioral manifestations in patients with behavioral variant of frontotemporal disorder (bvFTD), phenocopy frontotemporal dementia (phFTD), frontal variant of Alzheimer disease, bipolar disorder characterized with frontal damages.

Official Title
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Relationship Between Premorbid Personality Traits and Cognitive and Behavioral Disorders

Conditions
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Behavioral Variant of Frontotemporal Disorder (bvFTD), Phenocopy Frontotemporal Dementia (phFTD), Frontal Variant of Alzheimer Disease, Bipolar Disorder

Intervention / Treatment
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* Other: Submission of the NEO-PI-3 questionnaire
* Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria : Patients with behavioral variant of frontotemporal disorder (bvFTD) according to Rascovsky criteria (2011) or patients with phénocopy frontotemporal dementia (phFTD) who fulfill criteria for possible bvFTD and have no imaging abnormalities or patients with frontal variant of Alzheimer disease according to Ossenkopele criteria (2022), or patient with bipolar disorder according to CIM 10 criteria Score for Mini-mental state examination ≥ 18 Patient with caregiver who has who has known him/her in the 10 years preceding the disease onset. Patient and caregiver consents (no opposition) Exclusion Criteria : Patient with no caregiver Pregnant or breast feeding women

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Behavioral variant of frontotemporal disorder (bvFTD)<br>A group of participants who fulfill Rascovsky criteria (2011) for behavioural variant Frontotemporal Dementia | Other: Submission of the NEO-PI-3 questionnaire<br>* The questionnaire contains 240 statements. For each statement, the patient chooses the answer that best corresponds to their choice (FD: strongly disagree - D: disagree - N: neutral - A: agree - FA: strongly agree).<br>Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI)<br>* The test assesses two cognitive and two affective components of empathy that influence each other and affect attitudes and behaviors toward others.<br>|
| Phenocopy frontotemporal dementia (phFTD)<br>A group of participants who fulfill who fulfill Rascovsky criteria (2011) for possible behavioural variant Frontotemporal Dementia and have no imaging abnormalities. | Other: Submission of the NEO-PI-3 questionnaire<br>* The questionnaire contains 240 statements. For each statement, the patient chooses the answer that best corresponds to their choice (FD: strongly disagree - D: disagree - N: neutral - A: agree - FA: strongly agree).<br>Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI)<br>* The test assesses two cognitive and two affective components of empathy that influence each other and affect attitudes and behaviors toward others.<br>|
| Frontal variant of Alzheimer disease<br>A group of participants who fulfill Ossenkopele criteria (2022) | Other: Submission of the NEO-PI-3 questionnaire<br>* The questionnaire contains 240 statements. For each statement, the patient chooses the answer that best corresponds to their choice (FD: strongly disagree - D: disagree - N: neutral - A: agree - FA: strongly agree).<br>Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI)<br>* The test assesses two cognitive and two affective components of empathy that influence each other and affect attitudes and behaviors toward others.<br>|
| Bipolar disorder<br>A group of participants who fulfill CIM 10 criteria | Other: Submission of the NEO-PI-3 questionnaire<br>* The questionnaire contains 240 statements. For each statement, the patient chooses the answer that best corresponds to their choice (FD: strongly disagree - D: disagree - N: neutral - A: agree - FA: strongly agree).<br>Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI)<br>* The test assesses two cognitive and two affective components of empathy that influence each other and affect attitudes and behaviors toward others.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Premorbid personality traits | Premorbid personality traits will be assessed by the NEO- NEO Personality Inventory-3 (NEO-PI-3). The NEO PI-3 measures the five major domains of personality: Neuroticism, Extraversion, Openness to experience, Conscientiousness and Agreeableness. Each domain is defined by 6 facets. NEOPI-3 includes 240 items and responses are made on a 5-point Likert -type scale ranging from strongly Disagree to strongly agree. The NEOPI 3 will be completed by a caregiver who has known the patient in the 10 years preceding the disease onset. | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Interpersonal Reactivity Index (IRI) | IRI is a 28-item questionnaire measuring 4 aspects of empathy : perspective-taking, fantasy, empathic concern, personal distress. Each answer is rated from 1 (does not describe me well) to 5 (describes me very well). | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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bvFTD, fvAD, phFTD, bipolar disorder,personality