Screening for Risk Factors of Prediabetes Among Adult Patients at Sohag University Hospital

Study Overview
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Brief Summary
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Prediabetes is an intermediate state of hyperglycemia with glycemic parameters above normal but below the diabetes threshold.. during the average 3 years of follow-up Prediabetes is diagnosed based on laboratory tests: fasting plasma glucose level (100-125 mg/dl) ;HbA1c, (5.7-6.4%) or plasma glucose level after an oral glucose tolerance test ( 140-199 mg/dl). Reports estimate that more than 470 million people will have prediabetes by 2030. According to an expert panel of the American Diabetes Association, up to 70% of individuals with prediabetes will eventually develop diabetes. Observational evidence suggests as association between prediabetes and complications of diabetes such early nephropathy(10%) , small fiber neuropathy(18-25 %), early retinopathy (8-12%) and risk of macrovascular disease (52%) . Screening for prediabetes is designed to save lives or enhance an individual's quality of life by early detection so that screening will minimize the risk of developing diabetes or its complications .

Detailed Description
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In this case control study we aim to screen for risk factors of prediabetes among adult patients to minimize the risk of developing diabetes or its complications . Prediabetes screening is also required to minimize medical costs such as hospitalization, outpatient care, surgery, medications, and laboratory test costs . Several studies had shown efficacy of lifestyle interventions in diabetes prevention by targeting obesity with increase in physical activity and dietary changes with a relative risk reduction of 40%-70% in adults with prediabetes ,also there is increasing evidence to prove the efficacy of pharmacotherapy in prevention of diabetes in adults with prediabetes

Official Title
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Screening for Risk Factors of Prediabetes Among Adults Patients at Sohag University Hospital

Conditions
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PreDiabetes

Intervention / Treatment
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* Diagnostic Test: HbA1c
* Diagnostic Test: lipid profile
* Diagnostic Test: CBC
* Diagnostic Test: Alb/cr ratio
* Diagnostic Test: serum creatinine .
* Diagnostic Test: CRP
* Diagnostic Test: urine analysis
* Diagnostic Test: ECG
* Diagnostic Test: fundus examination


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patient above 18 years old . Exclusion Criteria: all patients known to be diabetics . pregnancy . chronic depleting diseases, Those who were taking drugs known to influence blood glucose levels e.g. metformin, thiazolidinedione and steroids.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| case group<br>prediabetic | Diagnostic Test: HbA1c<br>* HbA1c will be measured for all patients to minimize the risk of developing diabetes or its complications .<br>Diagnostic Test: lipid profile<br>* lipid profile will be measured for all patients to minimize the risk of developing diabetes or its complications .<br>Diagnostic Test: CBC<br>* CBC will be measured for all patients to minimize the risk of developing diabetes or its complications<br>Diagnostic Test: Alb/cr ratio<br>* Alb/cr will be measured for all patients to minimize the risk of developing diabetes or its complications<br>Diagnostic Test: serum creatinine .<br>* serum creatinine will be measured for all patients to minimize the risk of developing diabetes or its complications<br>Diagnostic Test: CRP<br>* CRP will be measured for all patients to minimize the risk of developing diabetes or its complications<br>Diagnostic Test: urine analysis<br>* urine analysis will be measured for all patients to minimize the risk of developing diabetes or its complications<br>Diagnostic Test: ECG<br>* ECG will be done for all patients to minimize the risk of developing diabetes or its complications<br>Diagnostic Test: fundus examination<br>* fundus examination will be done for all patients to minimize the risk of developing diabetes or its complications<br>|
| control group<br>non prediabetic | Diagnostic Test: HbA1c<br>* HbA1c will be measured for all patients to minimize the risk of developing diabetes or its complications .<br>Diagnostic Test: lipid profile<br>* lipid profile will be measured for all patients to minimize the risk of developing diabetes or its complications .<br>Diagnostic Test: CBC<br>* CBC will be measured for all patients to minimize the risk of developing diabetes or its complications<br>Diagnostic Test: Alb/cr ratio<br>* Alb/cr will be measured for all patients to minimize the risk of developing diabetes or its complications<br>Diagnostic Test: serum creatinine .<br>* serum creatinine will be measured for all patients to minimize the risk of developing diabetes or its complications<br>Diagnostic Test: CRP<br>* CRP will be measured for all patients to minimize the risk of developing diabetes or its complications<br>Diagnostic Test: urine analysis<br>* urine analysis will be measured for all patients to minimize the risk of developing diabetes or its complications<br>Diagnostic Test: ECG<br>* ECG will be done for all patients to minimize the risk of developing diabetes or its complications<br>Diagnostic Test: fundus examination<br>* fundus examination will be done for all patients to minimize the risk of developing diabetes or its complications<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| comparison between the measurement of HbA1c in normal non prediabetics and prediabetics at Sohag university hospital . | analysis of HbA1c measurements and compare the results in both groups | 6 months |