Orofacial Pain in Multiple Sclerosis

Study Overview
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Brief Summary
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Although the orofacial pain is not typical symptom of multiple sclerosis, more than 50% of the patients experience some kind of pain. Acute pain usually in form of trigeminal neuralgia, that occurred in 2-3% of patients with multiple sclerosis. Chronic pain occurred in 40-50% of patients and most common forms are headache. Aim of this study is to investigate prevalence and evaluate the form of orofacial pain in patients with multiple sclerosis treated in General hospital Varaždin in period from 01.01. 2017. to 31.12.2022. Results of this investigation will determine better understanding orofacial pain , treatment and impact on everyday life.

Detailed Description
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Multiple sclerosis is a chronic autoimmune disease with an unknown mechanism of origin. Although pain is not a typical symptom of multiple sclerosis, it occurs in more than 50% of patients and has significant impact on the quality of life of patients. Pain syndromes that patients with multiple sclerosis initially have characteristics of somatic and nociceptive pain, and later neuropathic, including trigeminal neuralgia, headaches, Lhermitte's syndrome. Pain is also often associated with anxiety and depression, which occurs in almost one third of patients. Pain therapy in these patients is a challenge for many doctors involved in the treatment. Many patients do not have adequate pain therapy due to the disproportion between the fear of interaction with other drugs and side effects, and on the other hand the treatment of basic diseases with the aim of controlling the immune response.

Official Title
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Orofacial Pain in Multiple Sclerosis

Conditions
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Multiple Sclerosis

Intervention / Treatment
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* Diagnostic Test: Diagnosis of pain


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: multiple scerosis age 18-85 years Exclusion Criteria: records with missing data

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Multiple sclerosis group<br>Multiple sclerosis patients registered in Varazdin General Hospital from 1 January 2017 - 31 December 2022 | Diagnostic Test: Diagnosis of pain<br>* Pain will be investigated - type, origin, level<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The frequency of orofacial pain in patients with multiple sclerosis | To investigate that, hospital records will be reviewed. Additionally, all of the patients will be approached with the questionnaire investigating the frequency of orofacial pain (expressed in number and proportion of all patients) | 3 months | 
| The location of orofacial pain in patients with multiple sclerosis | To investigate that, hospital records will be reviewed. Additionally, all of the patients will be approached with the questionnaire investigating the loacation of orofacial pain | 3 months | 
| The duration of orofacial pain in patients with multiple sclerosis | To investigate that, hospital records will be reviewed. Additionally, all of the patients will be approached with the questionnaire investigating the duration of orofacial pain (in months) | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MS therapy's influence to pain | To investigate connection between orofacial pain and multiple sclerosis therapy | 3 months | 
| MS orofacial pain and the duration of the disease | To investigate the connection between orofacial pain and the duration of the disease | 3 months | 
| Pain and patients' characteristics | To investigate the pain characteristics in relation to age, sex, form of the disease | 3 months | 
| Other chronic diseases and orofacial pain | To investigate the influence of other chronic diseases on orofacial pain in patients with multiple sclerosis | 3 months | 
| Pain and daily functioning | To investigate the impact of pain on the daily functioning of patients with multiple sclerosis | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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facial pain, craniofacial pain, multiple sclerosis