Comparison of the Effect of Preemptive and Post-operative Erector Spina Plane Block on Intraoperative Opioid Consumption and Postoperative Analgesia in Patients Who Will Undergo Elective Thoracotomy Surgery, Guided by the Nociception Level Index (NoL)

Study Overview
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Brief Summary
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The patients who will participate in the study will be determined and informed according to the inclusion and exclusion criteria, and the patients who signed the informed consent form will be included in the study.52 patients who will undergo elective thoracotomy surgery will be divided into double-blinded 2 sided as preemptive and postoperative erector spina plane block. Intraoperative pain status of the patients will be determined by the Nociception Level Index device and analgesia will be provided with fentanyl. The primary aim of the study is to compare the intraoperative opioid consumption of two groups with plan block at different times. In the postoperative period, patient-controlled analgesia device will be given to both groups for rescue analgesia. The opioid consumption of the patients will be controlled in this way in the postoperative period and their pain status will be determined. The secondary aim of the study is to examine the effect of plan block application time on the postoperative period.

Official Title
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Comparison of the Effect of Preemptive and Post-operative Erector Spina Plane Block on Intraoperative Opioid Consumption and Postoperative Analgesia in Patients Who Will Undergo Elective Thoracotomy Surgery, Guided by the Nociception Level Index (NoL)

Conditions
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Erector Spina Plan Block, Preemptive Analgesia, Thoracotomy, Nociception Level Index(NoL)

Intervention / Treatment
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* Procedure: Erector Spina Plan Block


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age between 18-65 years ASA classification <4 No history of allergy or hypersensitivity to the drugs we use throughout the procedure BMI ≤ 35 No history of neuropathy Surgeries other than emergency surgery Volunteer for the study No presence of infection at the injection site No any pyschiatric disease that would prevent the evaluation of the pain score Exclusion Criteria: Under the age of 18 or over the age of 65 ASA classification ≥ 4 History of allergy or hypersensitivity to the drugs we use throughout the procedure BMI > 35 History of neuropathy Undergoing emergency surgery Not be a volunteer for the study Presence of infection at the injection site Having a pyschiatric disease that would prevent the evaluation of the pain score Pregnancy Undergo surgery again during the postoperative follow-up period for any reason

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group 1<br>The group in which preemptive erector spina plane block was applied | Procedure: Erector Spina Plan Block<br>* Preemptive erector spina plan block and postoperative erector spina plan block were applied to patients undergoing thoracotomy. The effect of the time of application on intraoperative opioid consumption was compared with the Nociception Level Index pain monitor.<br>|
| Active Comparator: Group 2<br>The group in which the end of the surgery was applied to the erector spina plane block | Procedure: Erector Spina Plan Block<br>* Preemptive erector spina plan block and postoperative erector spina plan block were applied to patients undergoing thoracotomy. The effect of the time of application on intraoperative opioid consumption was compared with the Nociception Level Index pain monitor.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The value of Nociception Level Index (NoL) in both preemptive and postoperative groups | We aim to determine the effect of preemptive or postoperative application of ESPB ın the amount of intraopioid consumption by Nociception Level Index | Up to 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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preemptive analgesia, erector spina plan block, nociception level (NoL) index, thoracotomy, opioid consumption