1000 Eyes Lens Biometry Study: Artificial Intelligence for Intraocular Lens Power Calculation

Study Overview
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Brief Summary
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The main purpose of the study is to develop an AI approach to improve intraocular lens power calculations.

Detailed Description
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Cataract surgery is one of the most commonly performed surgeries worldwide and has a high postoperative patient satisfaction rate. Despite significant improvement in measurement methods and artificial lens power calculation formulas, miscalculations and subsequently refractive error still occur after cataract surgery. Most current artificial lens calculation methods use regression formulas. The concept of artificial intelligence (AI) has only recently found use and only in a rudimentary way. Examples include the Hill-RBF calculator and the Ladas superformula, but at least the superformula does not use a true AI approach and the results are no better than those obtained with conventional methods. The main purpose of the study is to develop an AI approach to improve intraocular lens power calculations. The data will be used for the following analysis: To compare the new AI method with conventional and modern formula (main question) To compare the refractive error for different eye lengths To use a ray tracing method to quantify sources of error in patients with a refractive surprise of at least 1.0 diopter To evaluate a novel concept of outlier testing using a modified nonparametric Walsh test This study will be multi-center and partially prospective. Data from 1000 patients who have already had cataract surgery will be analyzed. All patients will be invited for a visit to the recruitment clinic and the measurements will be performed.

Official Title
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The 1000 Eyes Lens Power Trial: Introducing Artificial Intelligence to Intraocular Lens Power Calculation

Conditions
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Cataract

Intervention / Treatment
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* Device: non contact measurement with the IOL Master 700


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pseudophakic (at least one eye): cataract surgery between 4 weeks and 24 months prior to recruitment If both eyes would be suitable for the study only the right eye will be included, if only one eye is suitable for the study, this eye will be included Pre-operative swept-source OCT biometry available (no ultrasound measurement for axial eye length) Uncomplicated cataract surgery Age 21 years and older Exclusion Criteria: Multifocal IOLs Combined surgery (cataract plus glaucoma/vitreoretinal/corneal surgery) Best corrected distance visual acuity below 0.5 Snellen In case of pregnancy (pregnancy test will be taken preoperatively in women of reproductive age)

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 110 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: non contact measurement with the IOL Master 700|postoerpative we will perform non contact measurement with the IOL Master 700|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| a new artificial intelligence based approach for intraocular lens power calculation | Developing an artificial intelligence algorithm to predict post-operative refraction | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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lens power calculation, biometry, artificial inteligence