Predictors of Chronic Kidney Disease Among Type 2 Diabetic Patients in Assiut University Hospitals

Study Overview
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Brief Summary
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Predictors of Chronic Kidney Disease among Type 2 Diabetic Patients in Assiut University Hospitals.

Detailed Description
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Globally, the total number of people with diabetes is estimated to increase from 415 million (8.8%) in 2015 to 642 million (10.4%) in 2040, with the largest alterations expected to occur in the urban population of low- to middle-income countries (LMICs)1. Of them, type 2 diabetes mellitus (T2DM) accounts for more than 90% of people with diabetes2,3. By 2040, the difference worldwide is projected to broaden, with 477.9 million affected people living in urban areas and 163.9 million in rural areas1. It has been postulated that the burden of diabetes and its complications in the LMICs may be contributed by the economic development and rapid urbanisation via increased caloric intake and the adoption of a sedentary lifestyle2,4,5. More importantly, the most striking demo graphic change to diabetes prevalence in global terms also seems to be related to the growth of the proportion of the elderly population6. Despite rates of diabetes-related complications such as CVDs decreasing significantly in the past two decades, it has not translated nearly as well as kidney complications7. Approximately 10% of deaths in people with T2DM are attributable to kidney failure8. It is well-established that diabetes-related chronic kidney disease (CKD) is the leading cause of end-stage kidney disease (ESKD) in T2DM patients worldwide9,10. In our study, we aim to identify and classify patients attending diabetic outpatient clinic with both CKD and

Official Title
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Predictors of Chronic Kidney Disease Among Type 2 Diabetic Patients in Assiut University Hospitals

Conditions
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Type 2 Diabetes With Renal Manifestations

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Patients with T2DM aged 18 years or older. For patients whom eGFR values < or =60 ml/min/1.73m2. Patient with type 2 DM and ESRD on regular HD with duration less than 1 year Exclusion Criteria: Having kidney transplantation incomplete data on glycemic control. Patients with type 2 DM and ESRD on regular HD with duration more than 1 year. Pregnant woman. Patients with advanced comorbides(cardiac, hepatic,

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| CKD patients with T2DM on regular HD<br>CKD patients with T2DM attending Assuit university diabetic outpatients clinic and ESRD on regular HD at dialysis unit of Assuit University Hospital | |
| CKD patients with T2DM not on regular HD<br>CKD patients with T2DM attending Assuit university diabetic outpatients clinic and ESRD not on regular HD at dialysis unit of Assuit University Hospital | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| predictors of CKD among T2DM patients attending Assiut University Hospitals. To classify our patients into stages according to KDIGO guidelines | To identify predictors of CKD among T2DM patients attending Assiut University Hospitals. To classify our patients into stages according to KDIGO guidelines | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the possible risk factors contributing to progessing CKD in T2DM patients. | To identify the possible risk factors contributing to progessing CKD in T2DM patients. | 3 years |