3/7 Resistance Training Method in Cardiac Rehabilitation

Study Overview
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Brief Summary
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Aim of the clinical monocentric study is to assess the resistance training exercise intervention in patients with Heart Failure with reduced Ejection Fraction (HFrEF) and coronary artery disease that will best improve peak oxygen uptake (Peak Vo2) and leg strength (assessed Isokinetic). The investigators hypothesize that resistance training exercise with induced a high stress metabolic is more important exercise with induced than a lower stress metabolic.

Official Title
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3/7 Resistance Training Method in Cardiac Rehabilitation of Coronary Artery Disease and Heart Failure With Reduced Ejection Fraction

Conditions
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Heart Failure, Coronary Artery Disease

Intervention / Treatment
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* Other: 3/7 Resistance Training Method
* Other: 3X9 Resistance Training Method


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical Coronary artery diseases Heart failure with reduced ejection fraction Exclusion Criteria: angina acutely decompensated heart failure electrocardiographic evidence of ischemia significant valvular disease orthopedic/neurologic disorders that limited exercise

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 3/7 RT method<br>perform interval- type endurance exercise at high intensity and resistance training with the 3/7 method | Other: 3/7 Resistance Training Method<br>* 3/7 Resistance Training Method<br>|
| Active Comparator: 3X9 RT method<br>perform interval- type endurance exercise at high intensity and resistance training with the 3X9 method | Other: 3X9 Resistance Training Method<br>* 3X9 Resistance Training Method<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Peak VO2 after 3 months | Change in Peak oxygen consumption (VO2) after three 3 months intervention | Baseline and 3 months | 
| Change in strength knee extensor after 3 months | Change in strength knee extensor (60°/sec) after three months intervention | Baseline and 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in VE/VCO2 slope after 3 months | Change in ventilatory efficiency (VE/VCO2) slope at baseline and 3 months intervention | Baseline and 3 months | 
| Change in submaximal exercise capacity after 3 months | Submaximal exercise capacity will be measured using watts at the first ventilatory threshold (VT1) | Baseline and 3 months | 
| Change in workload maximal after 3 months | Change in workload max at baseline and 3 months intervention | Baseline and 3 months | 
| Change in Body fat after 3 months | Change in Body fat at baseline and 3 months intervention | Baseline and 3 months | 
| Change in lean mass after 3 months | Change in lean mass at baseline and 3 months intervention | Baseline and 3 months | 
| Change in leg lean mass after 3 months | Change in leg lean mass at baseline and 3 months intervention | Baseline and 3 months | 
| Change in bone mass after 3 months | Change in bone mass at baseline and 3 months intervention | Baseline and 3 months | 
| Change in Visceral adipose tissue after 3 months | Change in Visceral adipose tissue measure by Dual-energy X- ray absorptiometry (DEXA) at baseline and 3 months intervention | Baseline and 3 months | 
| Change in hand grip force after 3 months | Change in hand grip force on non dominant hand at baseline and 3 months intervention | Baseline and 3 months | 
| Change in ventilation metaboreflex function after 3 months | Change in ventilation during metaboreflex test at baseline and 3 months intervention (Briefly, the subject is asked to exercise with the non-dominant arm by performing two 5 min handgrip manoeu- vres reaching approximately 50% of pre-determined maximal con- traction, in random order, separated by a 30 min interval: one bout with circulatory occlusion during the last 10 s of exercise and the all 3 min recovery phase ('clamp session'). During the clamp session, forearm cuff inflation to 30 mmHg above systolic blood pressure from the last 10 s of exercise till the end of the 3 min recovery phase; after cuff inflation, the subject is instructed to relax. Ergore- ceptor sensitivity is quantified as the percentage of the ventilatory and haemodynamic response to exercise maintained by circulatory occlusion during the third minute compared with the third minute of basal recovery.) | Baseline and 3 months | 
| Change in diastolic blood pressure metaboreflex function after 3 months | Change in diastolic blood pressure during metaboreflex test at baseline and 3 months intervention | Baseline and 3 months | 
| Change in heart rate at rest after 3 months | Change in heart rate at baseline and 3 months intervention | Baseline and 3 months | 
| Change in resting heart rate variability at rest after 3 months | Change in resting heart rate variability at baseline and 3 months intervention | Baseline and 3 months | 
| Change 30 s sit-to-stand after 3 months | Change 30 s sit-to-stand at baseline and 3 months intervention | Baseline and 3 months | 
| Change in isometric strength knee extensor after 3 months | Change in strength knee extensor (isometric) at baseline and 3 months intervention | Baseline and 3 months | 
| Change in 120°/sec strength knee extensor after 3 months | Change in strength knee extensor (120°/sec) at baseline and 3 months intervention | Baseline and 3 months | 
| Change in 180°/sec strength knee extensor after 3 months | Change in strength knee extensor (180°/sec) at baseline and 3 months intervention | Baseline and 3 months | 
| Change strength knee extensor in leg extension after 3 months | Change in one repetition maximal in leg extensor machine at baseline and 3 months intervention | Baseline and 3 months | 
| Change in sub maximal strength knee extensor in leg extension after 3 months | Change in 10 repetitions maximal in leg extensor machine at baseline and 3 months intervention | Baseline and 3 months | 
| Change in heart rate recovery after 3 months | Change in heart rate recovery at baseline and 3 months intervention | Baseline and 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cardiac rehabilitation, resistance training, strength training, exercise for older adults