Diagnosis and Comprehensive Treatment of Mediastinal Interventional Technique

Study Overview
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Brief Summary
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The goal of this observational study is to learn abou Whether patients undergoing mediastinal disease diagnosis and combined treatment with intrapacial ultrasound-guided mediastinal opening techniques have greater clinical benefit. The participants were physically ill. The main questions it aims to answer are: Whether the mediastinal ultrasound-guided mediastinal opening technique is more beneficial for the diagnosis of benign or malignant mediastinal diseases. Does the mediastinal ultrasound-guided mediastinal opening technique benefit the patient by ablating mediastinal masses using freezing, laser, or other means. Mediastinal diseases were diagnosed by lymph node biopsy combined with NGS, ROSE and other techniques using transairway ultrasound-guided mediastinal opening technique. Ablation of mediastinal malignancies is performed using techniques such as freezing or laser. Researchers will compare the experimental group with mediastinal opening and the control group without mediastinal opening to see if Mediastinal open technique benefits patients.

Official Title
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Application Value of Respiratory Mediastinal Intervention Technique in Diagnosis and Comprehensive Treatment of Diseases

Conditions
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Mediastinal Diseases

Intervention / Treatment
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* Procedure: Intraairway ultrasound-guided mediastinal opening technique


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Radiographic abnormalities of mediastinum Can tolerate general anesthesia Can tolerate bronchoscopy and has the condition to have mediastinal biopsy and treatment Exclusion Criteria: Imaging or other tests can make a definitive diagnosis Cannot tolerate general anesthesia or tracheoscopic surgery Patients cannot sign informed consent forms

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mediastinal open group<br>Mediastinal opening technique was performed with intraairway ultrasound guidance | Procedure: Intraairway ultrasound-guided mediastinal opening technique<br>* Mediastinal intervention for patients with mediastinal imaging abnormalities is performed under general anesthesia to obtain biopsy specimens for detection or elimination of mediastinal masses<br>|
| Non-mediastinal open group<br>Diagnosis and treatment are routinely performed without any manipulation of the mediastinum | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| In the diagnosis of mediastinal diseases, the difference in diagnosis rate between the experimental group with open mediastinum and the control group with traditional methods was observed | The contribution of pathological results to the final diagnosis of the disease between the experimental group and the control group was observed.That is, the difference in diagnostic accuracy between the experimental group and the control group. | 11 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall Survival |  | 11 months | 
| quality of life survey |  | 11 months | 
| number of hospitalizations |  | 11 months | 
| Cost of disease treatment |  | 11 months |