Evaluating the Efficacy of Resveratrol Containing Mouthwash as Adjunct Treatment Periodontitis:

Study Overview
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Brief Summary
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To evaluate the effectiveness of resveratrol mouthwash as adjunct to NSP treatment of periodontitis

Detailed Description
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Measuring and comparing the efficacy of RV mouth wash in comparison with CHX and placebo mouth wash in improving the clinical periodontal parameters; Measuring the salivary cytokines (IL-6) before and after 4weeks of the use of RV mouth wash as adjunct to NSP treatment in comparison with other mouthwash by using enzyme-linked immunosorbent assay. Measuring the salivary RANKL before and after 4weeks of the use of RV mouth wash as adjunct to NSP treatment in comparison with other mouthwash by using enzyme-linked immunosorbent assay. Correlate the salivary cytokines IL-6 and salivary RANKL with clinical periodontal parameter and with each other. Evaluate the intervention by using Visual analog scale (VAS)- score-based questionnaire will be filled out by each participant at the end of the trial.

Official Title
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Evaluating the Efficacy of Resveratrol Containing Mouthwash as Adjunct Treatment for Periodontitis:

Conditions
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Periodontitis

Intervention / Treatment
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* Other: resveratrol mouthwash as adjunct to scaling and root planing in periodontitis patients
* Other: chlorhexidine mouthwash as adjunct to scaling and root planing in periodontitis patients
* Other: placebo mouthwash as adjunct to scaling and root planing in periodontitis patients


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - The inclusion criteria: Participants need to be systemically healthy with age > 18 years old. Not taking antibiotic and anti-inflammatory drugs in the last three months. At least 20 teeth should be present Should have unstable periodontitis (PPD ≥ 5 or BOP at 4mm pocket) The exclusion criteria: Patients wearing fixed prosthesis (crowns, bridges or orthodontic appliances) Those with chronic disease, immunocompromised patients, pregnant, on contraceptives or lactating women. Those currently using any mouthwash. Those on antibiotic therapy and anti-inflammatory medications during the study and in the last 3 months before the study. Those having a history of hypersensitivity to any product used in the present study. Those who are smokers or alcoholics. Those who refuse to participate in the trial. -

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: the study include three groups. one of them is the study group in which the patient will use resveratrol mouthwash as adjunct to scaling, the second group use chlorhexidine mouthwas as adjunct to scaling while the third group will use a placebo. all the participants and the examiner are blinded regarding the type of the mouthwash they will be using
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: control<br>patients with periodontitis will receive scaling and rootplaning and a placebo mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month | Other: placebo mouthwash as adjunct to scaling and root planing in periodontitis patients<br>* patients with periodontitis will receive scaling and rootplaning and a placebo mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month<br>* Other names: placebo;|
| Active Comparator: chlorohexidine mouthwash<br>patients with periodontitis will receive scaling and rootplaning and a chlorhexidine mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month | Other: chlorhexidine mouthwash as adjunct to scaling and root planing in periodontitis patients<br>* patients with periodontitis will receive scaling and rootplaning and a chlorhexidine mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month<br>* Other names: chlorhexidine mouthwash (corsodyl);|
| Experimental: resveratrol mouthwash<br>patients with periodontitis will receive scaling and rootplaning and a resveratrol mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month | Other: resveratrol mouthwash as adjunct to scaling and root planing in periodontitis patients<br>* patients with periodontitis will receive scaling and rootplaning and a resveratrol mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month<br>* Other names: resveratrol mouthwash (oraxil);|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| bleeding on probing | bleeding on probing | at1 month from the baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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mouthwash, periodontitis, resveratrol