The Effect of Peripheral Nerve Blocks on Postoperative Analgesia in Elective Cesarean Section

Study Overview
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Brief Summary
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The goal of this prospective randomized study was to compare the efficacy of transversus abdominis plane block and transversalis fascia plane block for postoperative analgesia in patients undergoing elective cesarean section under spinal anesthesia. The main question[s] it aims to answer are: [Is transversalis fascia plane block more effective in postoperative analgesia? ] [Is there a difference between the duration of postoperative first analgesia requirement? ] Since the pain scores after the block at the end of the operation will be evaluated during the postoperative 24 hours, the participants will be asked to give a value between 0 and 10 in certain time periods.

Detailed Description
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This prospective, randomized trial was conducted at Başakşehir Çam and Sakura City Hospital by the Declaration of Helsinki. After ethics committee approval (decision no: 2022-74, date: 09.03.2022) and written informed consent was obtained from all patients, the trial was conduct-ed according to Consolidated Standards of Reporting Trials (CONSORT) guidelines.A total of 150 patients were divided into two groups: transversal fascia plane block (TFPB group) and Transversus abdominis plane block (TAPB group).VAS values, time to first analgesic requirement, analgesic requirements, nausea & vomiting and pruritus were evaluated for 24 hours postoperatively (6th hour (T2), 12th hour (T3), 24th hour .

Official Title
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Comparison of the Effectiveness of Ultrasound-guided Transversalis Fascia Plane Block and Transversus Abdominis Plane Block on Postoperative Pain in Caesarean Section : a Prospective Randomized Trial

Conditions
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Anesthesia; Sexual, Analgesia

Intervention / Treatment
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* Procedure: Patients undergoing transversalis fascia plane block
* Procedure: Patients undergoing transversus abdominis plane block


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 20-50 years old pregnant woman ASAII-III Patients accepting spinal anesthesia Exclusion Criteria: Morbid obesity(BMI >40) Patients who are switched to general anesthesia in an unexpected perioperative situation Patients with placental anomaly Patients with bupivacaine allergy Fetal distress situations too urgent to wait for spinal anesthesia and patients who do not want spinal anesthesia

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Prospective randomize study
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Grup 1: Transversalis Fascia Plane Block (TFPB)<br>Transversalis Fascia Plane Block (TFPB) | Procedure: Patients undergoing transversalis fascia plane block<br>* The investigators applied a transversalis fascia plane block to the group of patients who had a cesarean section under spinal anesthesia to prevent postoperative pain.<br>Procedure: Patients undergoing transversus abdominis plane block<br>* The investigators applied a transversus abdominis plane block to the group of patients who had a cesarean section under spinal anesthesia to prevent postoperative pain.<br>|
| Experimental: Grup 2: Transversus Abdominis Plane Block (TAPB)<br>Transversus Abdominis Plane Block (TAPB) | Procedure: Patients undergoing transversalis fascia plane block<br>* The investigators applied a transversalis fascia plane block to the group of patients who had a cesarean section under spinal anesthesia to prevent postoperative pain.<br>Procedure: Patients undergoing transversus abdominis plane block<br>* The investigators applied a transversus abdominis plane block to the group of patients who had a cesarean section under spinal anesthesia to prevent postoperative pain.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| time of first analgesic need | Our primary goal was to meet the initial analgesic requirement times. | 24 hours postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| visuel analog scale | Our secondary aim was to compare postoperative pain scores. The first 24 hours postoperatively were evaluated.Visual analog scale(VAS) was used to assess postoperative pain.6th, 12th, 24th hour VAS values were recorded For example, 0-10 where 0 is no pain and 10 is the worst pain imaginable. | 24 hours postoperatively | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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postoperative analgesia, anesthesia recovery period, cesarean section, obstetric anesthesia, spinal anaesthesia