Effectiveness of Cognitive Behavior Therapy for Persons With Depression

Study Overview
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Brief Summary
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This was a randomized controlled clinical trial (RCT) carried out in three different hospitals in Dhaka city, Bangladesh.

Detailed Description
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This was a randomized controlled trial, conducted to determine the effectiveness of CBT for depression delivered by trained therapists with an adapted Bengali CBT (BaCBT) manual, as compared to a control group. The main objective of the current study was to examine the efficacy of CBT for persons with major depression in Bangladesh.

Official Title
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A Randomized Controlled Trial of the Effectiveness of Cognitive Behavior Therapy for Major Depression in Bangladesh

Conditions
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Depression

Intervention / Treatment
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* Other: cognitive behavior therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed with Major Depression Must be able to take therapeutic session Exclusion Criteria: active suicidal ideation a co-morbid serious health condition with psychotic features currently on medication for depression with an intellectual disability

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Treatment group<br>cognitive behavior therapy one session per week six to eight session | Other: cognitive behavior therapy<br>* Psycho-therapeutic intervention<br>|
| Other: Wait list control group<br>waitlist control group offer CBT after completing data collection. | Other: cognitive behavior therapy<br>* Psycho-therapeutic intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Depression Scale | Depression Scale to measure depression. The total scale scores range from 30 to 150. Higher scores mean worse outcomes. | change from baseline to day 42, a separate outcome from day 42 to day 72 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Anxiety Scale | Anxiety Scale, the possible range of scores from 0 to 144 and Higher scores mean worse outcomes. | change from baseline to day 42, a separate outcome from day 42 to day 72 | 
| Change in General Health Questionnaire-28 | General Health Questionnaire-28, range of scores from 0 to 84, and Higher scores mean worse outcomes. | change from baseline to day 42, a separate outcome from day 42 to day 72 | 
| Change in Beck Scale for Suicidal Ideation | Beck Scale for Suicidal Ideation, range of scores from 0 to 42, and Higher scores mean worse outcomes. | change from baseline to day 42, a separate outcome from day 42 to day 72 |