Combination Regimen With Sodium Valproate for Severe Hemophilia B: a Single-arm, Phase 1, Pilot Trial.

Study Overview
=================
Brief Summary
-----------------
The goal of this clinical trial is to determine the clinical efficacy and toxic effects of sodium valproate, sirolimus and calcitriol in the treatment of severe haemophilia B in participants with severe haemophilia B. The main questions it aims to answer are the possibility of adding a combination regimen to primary treatment for severe haemophilia B. Patients will receive oral sodium valproate extended-release tablets 0.5g/day, sirolimus tablets 1mg/day and osteopontin capsules 0.25μg/day.

Official Title
-----------------
PLA General Hospital

Conditions
-----------------
Hemophilia B

Intervention / Treatment
-----------------
* Drug: Sodium valproate extended-release tablets


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with clinically confirmed severe haemophilia B; Expected survival of ≥ 24 weeks with an ECOG score of 0-2; Not having participated in another clinical trial within four weeks; Informed consent signed by the patient or an immediate family member. Exclusion Criteria: Those with other types of blood disorders diagnosed at the morphological or molecular level of the bone marrow; Significantly abnormal cardiopulmonary function; Hepatic or renal insufficiency; Pregnancy or lactation, or inability to use contraception during the trial and for three months before the test and one year after administration Persons who are allergic to the drugs likely to be used or where there is a contraindication to their use; Those with severe uncontrollable infectious diseases or uncontrolled hypertension, malignancy, etc.; Inability to cooperate with a regular follow-up due to psychological, social, family and other geographical circumstances; Any other condition that, in the investigator's opinion, makes participation in this trial inappropriate.

Ages Eligible for Study
-----------------
Minimum Age: 14 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Patients with severe haemophilia B<br>confirmed as hemophilia B and FIX activity <1% | Drug: Sodium valproate extended-release tablets<br>* Sodium valproate extended-release tablets 0.5g/day; sirolimus tablets 1mg/day and calcitriol capsules 0.25μg/day.<br>* Other names: calcitriol capsules;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| FIX Activity | FIX activity in peripheral blood | through study completion, an average of 1 month | 
| FIX inhibitor concentration | FIX inhibitor concentration in peripheral blood | through study completion, an average of 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| frequency of joint bleeding | Record the number of joint bleeds each month | through study completion, an average of 1 month | 
| Activated Partial Thromboplastin Time | activated partial thromboplastin time in peripheral blood | through study completion, an average of 1 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hemophilia B, Sodium valproate, Sirolimus, Calcitriol