Effects of Different Ventilatory Strategy on Intraoperative Atelectasis During Bronchoscopy Under General Anesthesia.

Study Overview
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Brief Summary
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This trial compares two different types of ventilation for the prevention of partial or complete collapsed lung (atelectasis) in patients undergoing interventional pulmonology procedures under general anesthesia. Ventilatory strategy to prevent reduce the intra-procedural development of atelectasis during interventional pulmonology procedures under general anesthesia.

Official Title
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Effects of Different Ventilatory Strategy on Intraoperative Atelectasis During Bronchoscopy Under General Anesthesia.

Conditions
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Lung Disorder

Intervention / Treatment
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* Procedure: VESPA
* Procedure: conventional mechanical ventilation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients undergoing interventional pulmonology procedures with radial probe endobronchial ultrasound (RP-EBUS) for peripheral lung lesions Recent (< 4 weeks) chest computed tomography (CT) performed prior to the bronchoscopy Exclusion Criteria: Patients with baseline lung consolidation, interstitial changes or lung masses (> 3 cm in diameter) in dependent areas of the lung (right/left [R/L] B6, 9, or 10 bronchial segments) as seen on most recent CT History of primary or secondary spontaneous pneumothorax

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: conventional mechanical ventilation<br>Conventional mechanical ventilation for General Anesthesia | Procedure: conventional mechanical ventilation<br>* Conventional mechanical ventilation for General Anesthesia.<br>|
| Experimental: VESPA<br>ventilatory strategy to prevent atelectasis for General Anesthesia | Procedure: VESPA<br>* Using Ventilatory strategy of prevent atelectasis for General Anesthesia.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence or absence of new atelectasis for each segment | The proportion of patients identified as developing intraprocedural atelectasis by radial probe endobronchial ultrasound (RP-EBUS) | During bronchoscopy, an average of 1 hour. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ventilation-induced complications |  | Within 48 hours of bronchoscopy | 
| Bronchoscopy-induced complications |  | Within 48 hours of bronchoscopy | 
| Assess the regional ventilation distribution by Electrical impedance tomography (EIT) |  | During bronchoscopy, an average of 1 hour. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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atelectasis, general anesthesia