Health Monitoring of Elderly Hypertensive Patients

Study Overview
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Brief Summary
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This study aims to monitor the health of elderly hypertensive patients in Tianjin.

Detailed Description
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From June 15th 2023 to August 31st 2023, and December 1st 2023 to February 28th 2024, the researchers will monitor the health indicators of 172 hypertensive patients between the ages of 60 and 65 in Wuqing District, Tianjin.For the sampling stage, two communities will be randomly selected in Wuqing District. The geographical distribution,urbanisation, population size, population structure, economic status, and health service resources of each selected community are in equilibrium.Meanwhile, the distance between the selected communities is greater than 5 km. Based on the list of chronic disease management records, 86 older hypertensive patients (male: female = 1:1) in each community will be involved in monitoring group and blank control group, respectively.Eligible individuals for this trial will be a mean untreated systolic blood pressure of at least 140 mmHg or a mean untreated diastolic blood pressure of at least 90 mmHg, or a mean treated systolic blood pressure of at least 130 mmHg or a mean treated diastolic blood pressure of at least 80 mmHg.Patients with a history of coronary heart disease, heart failure, stroke or diabetes were excluded. For the monitoring stage, different groups are monitored in different ways, including questionnaire surveys,monitoring of health indicators,health checkups and biological sample collection. The exposure temperature, electrocardiography(ECG), and blood pressure indicators will be monitored every day during the study period in the monitoring group,respectively.The blank control group will only monitor the exposure temperature every day. Besides, the study period will be divided into three parts including early, mid, and late period, respectively, and all the patients will have questionnaire surveys, health checkups and biological sample collections once in the early, mid, and late period.Biological biomarkers of inflammation and oxidative stress in the cardiovascular system will be tested. The content of the questionnaire will include individual fundamental information, sleep quality, hypertension medication.

Official Title
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Health Monitoring of Elderly Hypertensive Patients in Tianjin, China

Conditions
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Hypertension

Intervention / Treatment
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* Behavioral: The electrocardiography(ECG) and blood pressure monitoring


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 60 ≤ 65 years old Volunteer to participate in this study Exclusion Criteria: Patients with a history of coronary heart disease, heart failure, stroke or diabetes were excluded. Unable to cooperate with follow-up

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| The Monitoring Group<br>The exposure temperature, electrocardiography(ECG), and blood pressure indicators will be monitored every day during the study period in the monitoring group. | Behavioral: The electrocardiography(ECG) and blood pressure monitoring<br>* The electrocardiography (ECG) and blood pressure indicators will be monitored every day during the study period in the monitoring group.<br>|
| The Blank Control Group<br>The blank control group will only monitor the exposure temperature every day. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Observation indicators:Individual fundamental information | Weight and height will be combined to report BMI in kilogram/meter^2 (kg/m^2). | six months | 
| Observation indicators:Sleep quality | By answering the survey questionnaire, the duration of sleep (hours) was obtained. | six months | 
| Functional indicators:Blood pressure | Diastolic pressure and systolic pressure in millimetre of mercury (mmHg). | six months | 
| Functional indicators:Monitoring indicators of electrocardiogram - heartrate | AverageHeartRate in beat per minute(bpm),MaxHeartRate in bpm,MinHeartRate in bpm. | six months | 
| Functional indicators:Monitoring indicators of electrocardiogram - interval | ECG QT interval inMillisecond(ms),PR interval in ms. | six months | 
| Functional indicators:Monitoring indicators of electrocardiogram - electrical axis | QRS Electrical axis in degree. | six months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Experimental test index:Biomarkers of inflammation in the cardiovascular system - protein | Cardiac troponin in microgram/litre(μg/L),Heart fatty acid binding protein in μg/L,C-reactive protein in μg/L,D-dimer in μg/L,Myoglobin in μg/L. | six months | 
| Experimental test index:Biomarkers of inflammation in the cardiovascular system - enzyme | Creatine kinase isoenzyme-MB in unit/liter(U/L). | six months | 
| Experimental test index:Biomarkers of inflammation in the cardiovascular system - cytokine | Interleukin-6 in picogram/milliliter(pg/ml). | six months | 
| Experimental test index:Biomarkers of inflammation in the cardiovascular system - peptide | B-type natriuretic peptides in picogram/litre(pg/L),NT-proBNP in pg/L. | six months |