Comparison of Cryotherapy and Peeling Agent in the Treatment of Common Warts

Study Overview
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Brief Summary
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Objective: To compare the efficacy of cryotherapy using liquid nitrogen (cryoget method) versus trichloroacetic acid 90% (applicator method) in treatment of common warts. Study Design: Randomized Control Trial. Place And Duration of Study: Department of Dermatology, CMH Abbottabad from Jun 2022 to Nov, 2022.

Detailed Description
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A total of 60 patients were enrolled in this investigation by non-probability consecutive sampling technique. Sample size was calculated using WHO sample size calculator and patients were randomized into two equal groups, A and B, each comprising of 30 patients through lottery method. Patients with common warts such as hard lesions, raised lumps with rough surfaces at the back of their fingers, around nails and palm of their hands between the ages of 18 and 60 were included, whereas those with genital warts, cardiac, hepatic, renal, or hypercholesterolemia were excluded.

Official Title
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Cryotherapy Versus Topical Tricholoacetic Acid 90% in Treatment of Common Warts

Conditions
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Warts

Intervention / Treatment
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* Drug: CRYOTHERAPY
* Drug: Tricholoracetic acid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient presented with common warts in dermatology opd Exclusion Criteria: • Patients with warts on toes and tip of fingers genital warts cardiac, hepatic and renal disease hypercholesterolemia hypersensitivity reactions

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group A cryotherapy<br>Cryotherapy Group A had their warts treated once every two weeks for a total of twelve weeks, with liquid nitrogen using cryoget method for 10 to 15 seconds on each lesion (depending on size, until a narrow white rim of around 1 mm developed around it). | Drug: CRYOTHERAPY<br>* Group A had their warts treated once every two weeks for a total of twelve weeks, with liquid nitrogen using cryoget method for 10 to 15 seconds on each lesion (depending on size, until a narrow white rim of around 1 mm developed around it).<br>* Other names: Liquid nitrogen;|
| Active Comparator: Group B Topical TCA 90%<br>Topical TCA 90 % Warts in Group B were treated with liquid TCA 90% by an applicator every two weeks for a total of twelve weeks. After 20 minutes, patients were instructed to remove the solution by washing their warts with water or regular saline | Drug: Tricholoracetic acid<br>* Group B were treated with liquid TCA 90% by an applicator every two weeks for a total of twelve weeks. After 20 minutes, patients were instructed to remove the solution by washing their warts with water or regular saline.<br>* Other names: Peeling agent;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of cryotherapy and Tricholoracetic acid 90% in treatment of common warts | Outcome was determined at the end of third month and the patients were labelled as cured and the efficacy was labelled as Yes in cases with absence of all the lesions. After twelve weeks of therapy, individuals with persistent warts were regarded as cases of treatment failure and efficacy was labelled as No. | 12 weeks |