Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity

Study Overview
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Brief Summary
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Resting tremors associated with Parkinson's disease (PD) remains difficult to quantify and track during disease progression. This study propose to explore the rhythmicity of distal muscle contractions in the upper limb to characterize resting tremor and discriminate it from cerebellar tremor (CT) based on the frequency spectrum of the EMG signal.

Detailed Description
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This retrospective study analyzed surface EMG recordings of wrist flexor-pronators and extensor-supinators from patients with PD or CT bilaterally in five 10-second conditions: rest with contralateral motor distraction, symmetrical arms extended forward posture with hands pronated, semi-pronation, supination, and elbows flexed with hands pronated. The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz.

Official Title
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Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity

Conditions
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Parkinson, Cerebellar Tumor, Rest Tremor, Diagnoses Disease, Movement; Abnormal, Involuntary

Intervention / Treatment
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* Diagnostic Test: EMG in wrist flexor-pronators and extensor-supinators


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patient who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators in Laboratories; diagnosis of Parkinson's disease or cerebellar tremor. Exclusion Criteria: Botulinium toxin injection in upper limb during a delay of 3 months before surface EMG recordings; Levodopa drugs administrated during a delay of 12 hours before surface EMG recordings; Tremor-favour drugs administrated during a delay of 30 days before surface EMG recordings; Presence of an other neurologic disease or of any disease associated with motor disorders in upper limb.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Tremor of rest<br>Patient with a diagnosis of Parkinson's disease and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories | Diagnostic Test: EMG in wrist flexor-pronators and extensor-supinators<br>* The subject is asked to perform a series of tasks: resting posture, symmetrical posture arms forward, unilateral distal movement. Each task lasts 10 seconds.<br>|
| Cerebellar tremor<br>Patient with a diagnosis of cerebellar tremor and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories | Diagnostic Test: EMG in wrist flexor-pronators and extensor-supinators<br>* The subject is asked to perform a series of tasks: resting posture, symmetrical posture arms forward, unilateral distal movement. Each task lasts 10 seconds.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rhythmicity index | The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz. | 10 seconds |