Dosage of Propofol Based on Lean Body Weight

Study Overview
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Brief Summary
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Patients who will be induction of anesthesia with propofol will have a body analysis with Tanita before the operation. Patients' height, weight, age, gender and other general information will be recorded. Total body weight (TBW), ideal body weight (IBW) and lean body weight (LBW) of the patients will be calculated. Patients over the age of 18 who will be operated under general anesthesia for 2-6 hours will be included. Patients with propofol allergy or contraindicated to propofol are included in the study. In order to decide and try the most appropriate weight-based scalar for propofol dosing for anesthesia induction to be evaluated by specifying patients who need additional propofol during intubation in the study, Ingrande et al. 80 patients with a mean body mass index [BMI] between 18-35 and Bispectoral index (BIS). ) monitorization, propofol infusion (100 mg/kg/hour) will be started according to total body weight, and the infusion will be stopped with a BIS value between 50 and 40, and the elapsed time will be recorded. Routine anesthesia applications will be performed with neuromuscular blocker applied. The total dose of Propofol given; the dose applied to kilograms will be calculated according to TBW, IBW and LBW. And the relationship between the given doses and the body mass index will be evaluated.

Detailed Description
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Patients who will be induction of anesthesia with propofol will have a body analysis with Tanita before the operation. Patients' height, weight, age, gender and other general information will be recorded. Total body weight (TBW), ideal body weight (IBW) and lean body weight (LBW) of the patients will be calculated. Patients over the age of 18 who will be operated under general anesthesia for 2-6 hours will be included. Patients with propofol allergy or contraindicated to propofol are included in the study. In order to decide and try the most appropriate weight-based scalar for propofol dosing for anesthesia induction to be evaluated by specifying patients who need additional propofol during intubation in the study, Ingrande et al. 80 patients with a mean body mass index [BMI] between 18-35 and Bispectoral index (BIS). ) monitorization, propofol infusion (100 mg/kg/hour) will be started according to total body weight, and the infusion will be stopped with a BIS value between 50 and 40, and the elapsed time will be recorded. Routine anesthesia applications will be performed with neuromuscular blocker applied. The total dose of Propofol given; the dose applied to kilograms will be calculated according to TBW, IBW and LBW. And the relationship between the doses given and the body mass index will be evaluated. In our study, we aimed to evaluate the effects of Propofol dose according to lean body weight by evaluating patients with bodymass index below 35.Patients who will be induction of anesthesia with propofol will have a body analysis with Tanita before the operation. Patients' height, weight, age, gender and other general information will be recorded. Total body weight (TBW), ideal body weight (IBW) and lean body weight (LBW) of the patients will be calculated. Patients over the age of 18 who will be operated under general anesthesia for 2-6 hours will be included. Patients with propofol allergy or contraindicated to propofol are included in the study. In order to decide and try the most appropriate weight-based scalar for propofol dosing for anesthesia induction to be evaluated by specifying patients who need additional propofol during intubation in the study, Ingrande et al. 80 patients with a mean body mass index [BMI] between 18-35 and Bispectoral index (BIS). ) monitorization, propofol infusion (100 mg/kg/hour) will be started according to total body weight, and the infusion will be stopped with a BIS value between 50 and 40, and the elapsed time will be recorded. Routine anesthesia applications will be performed with neuromuscular blocker applied. The total dose of Propofol given; the dose applied to kilograms will be calculated according to TBW, IBW and LBW. And the relationship between the doses given and the body mass index will be evaluated. In our study, we aimed to evaluate the effects of Propofol dose according to lean body weight by evaluating patients with bodymass index below 35.

Official Title
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Lean Body Weight Scalar for the Anesthetic Induction Dose of Propofol

Conditions
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Gender, Anesthesia

Intervention / Treatment
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* Other: It is an observational study and no non-routine procedures will be performed on patients. Routine anesthesia procedure will be applied to the patients


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI 18-35 will be included. over 18 years old It will take 2-6 hours Patients who will be operated under general anesthesia will be included. - Exclusion Criteria: PATIENT DOESN'T WANT CONTRAINDICATION OF PROPOFOL Propofol allergy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| grup1<br>Group 1 BMI = 18.5-24.9, | Other: It is an observational study and no non-routine procedures will be performed on patients. Routine anesthesia procedure will be applied to the patients<br>* It is an observational study and no non-routine procedures will be performed on patients. Routine anesthesia procedure will be applied to the patients<br>|
| Group 2 BMI = 25-29.9<br>BMI = 25-29.9, | Other: It is an observational study and no non-routine procedures will be performed on patients. Routine anesthesia procedure will be applied to the patients<br>* It is an observational study and no non-routine procedures will be performed on patients. Routine anesthesia procedure will be applied to the patients<br>|
| Group 3<br>BMI=30-34.9 | Other: It is an observational study and no non-routine procedures will be performed on patients. Routine anesthesia procedure will be applied to the patients<br>* It is an observational study and no non-routine procedures will be performed on patients. Routine anesthesia procedure will be applied to the patients<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PROPOFOL DOSE | THE RATIO OF PROPOFOL DOSE WITH SUFFICIENT DEPTH OF ANESTHESIA ACCORDING TO TOTAL AND LEATHER BODY WEIGHT | 2 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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the lean body weight, propofol intubation conditions