Effect of Different Remineralization Gels

Study Overview
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Brief Summary
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The aim of the study is to treat white spot lesions that occur after orthodontic treatment. Different gels will be used for remineralization. The study will consist of 45 people between the ages of 15-18. 45 people will be divided into 3 groups.

Detailed Description
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Oral hygiene training will be given to each group and a toothpaste containing 1450 ppm fluoride will be given to brush their teeth twice a day. Essix appliance with reservoir will be made by taking impressions from 30 patients. Remineralization gel will be put into the Essix appliance for 5-7 minutes twice a day for one month.

Official Title
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Effect of Different Remineralization Gels on the White Spot Lesions

Conditions
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White Spot Lesion

Intervention / Treatment
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* Other: Remineralization gel


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged 15-18 years, Presence of white point lesions, Volunteering to participate in the research. Exclusion Criteria: Not having received orthodontic treatment, Having a developmental anomaly affecting the enamel, Being allergic to milk, Having a syndrome affecting the oral cavity.

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Remineralization gel with CPP- ACP (GC Tooth MousseTM, Tokyo, Japan)<br>CPP-ACP containing remineralization gel (Tooth Mousse GC, Tokyo, Japan) will be put into the Essix appliance with a reservoir and applied for 5-7 minutes twice a day for one month. Before and after the applying remineralization gel, the laser fluorescence values will measure with a DIAGNOdent pen (KaVo Dental corporation, East Main street Lake Zurich, lL). | Other: Remineralization gel<br>* Remineralization gel<br>|
| Experimental: Remineralization gel with calcium glycerophosphate (R.O.C.S.® Medical Mineral Gel, Russia)<br>Remineralization gel containing calcium glycerophosphate (R.O.C.S.® Medical Minerals Gel, Russia) will be put into the Essix appliance with a reservoir for 5-7 minutes twice a day for one month. Before and after the applying remineralization gel, the laser fluorescence values will measure with a DIAGNOdent pen( KaVo Dental corporation, East Main street Lake Zurich, lL). | Other: Remineralization gel<br>* Remineralization gel<br>|
| No Intervention: Control Group<br>No intervention. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) | Decrease in laser fluorescence values with Diagnodent Pen as an indicator of remineralization | 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Calcium glycerophosphate | Decrease in laser fluorescence values with Diagnodent Pen as an indicator of remineralization | 4 weeks |