SIRT1(rs7069102 ) Gene Polymorphism in Chronic Obstructive Pulmonary Disease at Egyptian Patients

Study Overview
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Brief Summary
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Chronic obstructive pulmonary disease (COPD) prevalence, morbidity, and mortality vary across countries and across different groups within countries with a direct relation to the prevalence of tobacco smoking. Other risk factors for COPD include genetic factors, longstanding asthma, outdoor air pollution, second-hand smoke exposure, biomass smoke, indoor air pollution, occupational exposures, and tuberculosis . The prevalence and burden of COPD are projected to increase in the coming decades because of continued exposure to COPD risk factors and the changing age structure of the world's population. As these factors are rapidly increasing in developing countries, COPD will become a major health problem, exerting a huge demand on economic and healthcare resources in developing countries [2]. In Egypt, although COPD is a rising significant health problem, data on its prevalence, morbidity, and mortality are still lacking and have to be estimated . Sirtuin 1 (SIRT1) is a protein/histone deacetylase dependent NAD. It plays a crucial role in various human diseases such as cardiovascular diseases, cancer, inflammation, aging, neurodegenerative disease, obesity and type 2 diabetes. Seven isoforms of the SIRT1 gene (SIRT1- SIRT7) have been determined in mammals. Expression of the SIRT1 gene is regulated by transcription factors such as CREB, FOXO3, HIC1, NF-KB, p53, PARP-2 and PPAR. SIRT1

Official Title
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SIRT1(rs7069102 ) Gene Polymorphism in Chronic Obstructive Pulmonary Disease at Egyptian Patients

Conditions
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Genotyping of SIRT1in Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Genetic: genotyping of SIRT1 in chronic obstructive patients


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients admitted to Sohag University Hospital, chest department. Exclusion Criteria: Patients with malignancies, any other chronic disease, Individuals with a history of known chronic cardiorespiratory diseases and those with collagen vascular diseases were excluded.

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients more than 40 years<br> | Genetic: genotyping of SIRT1 in chronic obstructive patients<br>* genotyping of SIRT1 in chronic obstructive patients<br>|
| patients less than 40 years<br> | Genetic: genotyping of SIRT1 in chronic obstructive patients<br>* genotyping of SIRT1 in chronic obstructive patients<br>|
| controls<br> | Genetic: genotyping of SIRT1 in chronic obstructive patients<br>* genotyping of SIRT1 in chronic obstructive patients<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SIRT1(rs7069102 ) Gene polymorphism in chronic obstructive pulmonary disease | genotyping of sirt1 in chronic obstructive pulmonary disease | 2 months |