HCG Levels After Ovulation Triggering as Predictors of ICSI Outcome

Study Overview
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Brief Summary
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This study aimed to assess the correlation between HCG levels after ovulation triggering and ICSI outcomes, affected by HCG formulation and dose

Detailed Description
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The aims of this study are: To assess the correlation between serum human chorionic gonadotropin (hCG) level after ovulation triggering and intracytoplasmic sperm injection (ICSI) outcome including: oocyte maturity and quality, good quality embryo rate, blastocyst formation rate and pregnancy rate To determine if there is an association between type and dose of the trigger and ICSI outcome.

Official Title
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Human Chorionic Gonadotropin Levels After Ovulation Triggering as Predictors of Intracytoplasmic Sperm Injection Outcome

Conditions
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Infertility

Intervention / Treatment
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* Drug: uHCG
* Drug: rHCG
* Drug: uHCG and GnRHa


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Women who will undergo controlled ovarian stimulation (COS) through fixed GnRH antagonist protocol Exclusion Criteria: BMI > 30 kg/m2 Irregular menstruation Severe male factor abnormality Poor ovarian reserve Endometriosis Uterine abnormality

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| uHCG group<br>Trigger intramuscular (IM) administration of 10000 IU of uHCG | Drug: uHCG<br>* Final oocyte maturation will be triggered by IM administration of 10000 IU of uHCG (Choriomon)<br>* Other names: Choriomon;|
| rHCG group<br>Trigger with subcutaneous (SC) administration of 6500 IU of rHCG | Drug: rHCG<br>* Final oocyte maturation will be triggered by SC administration of 6500 IU of rHCG (Ovitrelle)<br>* Other names: Ovitrelle;|
| Dual trigger group<br>Combined SC administration of 0.1 mg of GnRHa and IM administration of 2500 IU of uHCG | Drug: uHCG and GnRHa<br>* Final oocyte maturation will be triggered by combined SC administration of 0.1 mg of GnRHa (Decapeptyl, Triptorelin) and IM administration of 2500 IU of uHCG (Choriomon)<br>* Other names: Decapeptyl and Choriomon;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical pregnancy rate | Number of clinical pregnancies (defined as presence of at least one intrauterine gestational sac with fetal pole and cardiac activity on TVS scan at 4-6 weeks after the ET) divided by the number of ET procedures | 6 weeks after embryo transfer | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Oocyte maturation rate | Number of mature oocytes divided by the number of retrieved oocytes | On 1 day of oocyte retrieval | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ovulation triggering, uHCG, rHCG, GnRH, Dual trigger