Personality Change Study for Borderline Personality Disorder

Study Overview
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Brief Summary
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Participants with borderline personality disorder will undergo an a 2 - 4 week baseline assessment to determine level of outcomes of interest in the absence of treatment. After the baseline period, participants will receive six weekly 50-60-minute treatment sessions. After the 6 treatment sessions, participants will complete a 4-week follow-up period to determine the sustainability of the treatment module.

Official Title
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Engaging Higher-Order Mechanisms of Psychopathology: A Parsimonious Approach to Precision Medicine

Conditions
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Borderline Personality Disorder

Intervention / Treatment
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* Behavioral: Personality-Based Therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Speak English fluently Diagnosis of Borderline Personality Disorder Exclusion Criteria: diagnosed psychological conditions that would be better addressed by alternative treatments concurrent psychotherapy medication instability substance use disorder

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Personality-based treatment 2 week baseline<br>Participants will receive treatment tailored to 1 of 3 personality dimensions after a 2 week baseline assessment | Behavioral: Personality-Based Therapy<br>* Participants will be randomized to a 2- or 4-week assessment-only baseline period. After the baseline period, participants will receive the personality-based treatment module corresponding to their highest clinical elevation (i.e., neuroticism, [low] conscientiousness, [low] agreeableness). Treatment will consist of six weekly 50-60-minute sessions. After the 6-week intervention period, participants will complete a 4-week follow-up period to determine the sustainability of effects observed<br>|
| Experimental: Personality-based treatment 4 week baseline<br>Participants will receive treatment tailored to 1 of 3 personality dimensions after a 4 week baseline assessment | Behavioral: Personality-Based Therapy<br>* Participants will be randomized to a 2- or 4-week assessment-only baseline period. After the baseline period, participants will receive the personality-based treatment module corresponding to their highest clinical elevation (i.e., neuroticism, [low] conscientiousness, [low] agreeableness). Treatment will consist of six weekly 50-60-minute sessions. After the 6-week intervention period, participants will complete a 4-week follow-up period to determine the sustainability of effects observed<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in clinician-rated borderline personality disorder symptoms | Change in borderline personality disorder symptoms will be measured using Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) - clinician-rated version. Scores range from 0-36; higher scores indicate greater severity of borderline personality disorder symptoms | up to 14 weeks (pre-baseline, pre-intervention, post-intervention, post-follow-up) | 
| Change in patient-reported borderline personality disorder symptoms | Change in borderline personality disorder symptoms will be measured using Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) - self-report version. Scores range from 0-36; higher scores indicate greater severity of borderline personality disorder symptoms | weekly up to 14 weeks |