Evaluation of the Effectiveness of the Self-developed Pulmonary Lobar Ventilation Detector

Study Overview
=================
Brief Summary
-----------------
The goal of observational study is to Evaluation of the effectiveness of the self-developed pulmonary lobar ventilation detector in Chronic Obstructive Pulmonary Disease. The main question it aims to answer are:Evaluation of the effectiveness of the self-developed pulmonary lobar ventilation detector. Participants will use the self-developed pulmonary lobar ventilation detector and the imported Chartis detection system to evaluate the target pulmonary lobar collateral ventilation.

Official Title
-----------------
Evaluation of the Effectiveness of the Self-developed Pulmonary Lobar Ventilation Detector

Conditions
-----------------
Chronic Obstructive Pulmonary Disease

Intervention / Treatment
-----------------
* Device: Self-developed pulmonary lobar ventilation detector
* Device: Chartis detection system


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with chronic obstructive pulmonary disease who meet the GOLD diagnostic criteria FEV1 ≤ 45% pred and FEV1/FVC<70% TLC>100% pred and RV>175% pred CAT≥18 >50% of emphysema destruction Smoking prohibition>6 months Sign the informed consent form Exclusion Criteria: PaCO2>8.0 kPa, or PaO2<6.0 kPa 6-minute walking test<160m Obvious chronic bronchitis, bronchiectasis or other infectious lung diseases Three hospitalizations due to pulmonary infection in the past 12 months before the baseline assessment Previous lobectomy, LVRS or lung transplantation LVEF<45% and or RVSP>50mmHg Anticoagulant therapy that cannot be stopped before surgery The patient has obvious immune deficiency Participated in other lung drug studies within 30 days before this study Pulmonary nodules requiring intervention Any disease or condition that interferes with the completion of the initial or subsequent assessment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Self-developed pulmonary lobar ventilation detector<br> | Device: Self-developed pulmonary lobar ventilation detector<br>* The participants would evaluated by the self-developed pulmonary lobar ventilation detector.<br>|
| imported Chartis detection system<br> | Device: Chartis detection system<br>* The participants would evaluated by the Chartis detection system.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Therapeutic effect of lung volume reduction surgery | Lung CT | 1 month after bronchoscopic valve lung volume reduction | 
| Therapeutic effect of lung volume reduction surgery | Lung CT | 3 months after bronchoscopic valve lung volume reduction | 
| Therapeutic effect of lung volume reduction surgery | Lung CT | 6 months after bronchoscopic valve lung volume reduction | 
| the integrity of interlobar fissure | Use the self-developed pulmonary lobar ventilation detector and the imported Chartis detection system to evaluate the target pulmonary lobar collateral ventilation | Before bronchoscopic valve lung volume reduction |