linjc16/ctgov huggingface dataset:
Arthroscopic Partial Trapezictomy With Hematoma Distraction in Basal Thumb Arthritis

Study Overview
=================
Brief Summary
-----------------
The basal joint, also referred to as the carpometacarpal (CMC) joint, of the thumb is one of the joints most commonly affected by arthritis. CMC joint arthritis can lead to decreased grip and pinch strength and impairment of activities of daily living

Detailed Description
-----------------
The thumb CMC joint has been reported as the most painful joint when compared to other hand joints affected by OA. It is therefore no surprise that this is a common chief complaint of patients and has a significant effect on work and life satisfaction Patients often present with complaints of pain localized to the base of the thumb that is exacerbated when performing tasks such as opening a jar, turning a car key, and turning door Knob, this pain may be reproduced by resisted pinch and grip . On physical examination, patients will have point tenderness at the thumb basal joint with swelling and crepitus when the basal joint is compressed - a positive grind test and a positive hump sign from dorsal CMC dislocation subluxation .

Official Title
-----------------
Arthroscopic Partial Trapeziectomy With Hematoma Distraction in Basal Thumb Arthritis

Conditions
-----------------
Orthopedic Disorder

Intervention / Treatment
-----------------
* Procedure: wrist arthroscopy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age: adult patient > 20years. Gender: Males & Females. Symptomtic patient. Failed conservative treatment of 6 months duration Eaton stage II, III and IV of base thumb arthritis Exclusion Criteria: Patient presenting with flexor carpi radialis rupture Previous Zancolli arthroplasty Associated comorbidity as: RA,DM with joint destruction Infection Poor Skin Condition Active Pateint With High Joint Demand

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Arthroscopic partial Trapezictomy With Hematoma Distraction<br> | Procedure: wrist arthroscopy<br>* Arthroscopic Partial Trapeziectomy with Hematoma Distraction in Basal Thumb Arthritis<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| DASH score | score for pinch grip | 1 year |
Rates and Risk Factors of Contact Between the OTX-TIC Intracameral Ocular Implant and Corneal Endothelium

Study Overview
=================
Brief Summary
-----------------
To determine what proportion of patients have inferior angle recess dimensions that could accommodate the OTX-TIC, and what are risk factors for implant contact with the corneal endothelium.

Official Title
-----------------
Rates and Risk Factors of Contact Between the OTX-TIC Intracameral Ocular Implant and Corneal Endothelium

Conditions
-----------------
Corneal Endothelium

Intervention / Treatment
-----------------
* Other: OCT Imaging


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age over 40 years No history of ocular surgery other than cataract surgery Exclusion Criteria: - Media opacities that preclude OCT imaging of the anterior segment

Ages Eligible for Study
-----------------
Minimum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: OCT Imaging|Each participant will receive imaging of the inferior sectors of the iridocorneal angle at 150°, and 180°, and 210° with the swept-source ANTERION AS-OCT system under standardized light and dark lighting conditions by a trained research technician|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Primary Outcome 1 | Predict contact between simulated OTX-TIC implant and corneal endothelium imaged using the ANTERION AS-OCT system. | 4-6 Months | 
| Primary Outcome 2 | Characterize the variability in distance (mean and standard deviation) between the angle recess and Schwalbe's line | 4-6 Months | 
| Primary Outcome 3 | Calculate the proportion of eyes with predicted contact between the simulated implant and corneal endothelium. | 4-6 Months | 
| Primary Outcome 4 | Develop logistic regression models to identify demographic, clinical, and biometric risk factors for predicted contact. | 4-6 Months |
A Study of Invasive Hemodynamic for MACHD Registry

Study Overview
=================
Brief Summary
-----------------
This research study is being done to provide comparative data to the Mayo Clinic Adult Congenital Heart Disease Registry.

Official Title
-----------------
Invasive Hemodynamic Control Cohort for The Mayo Clinic Adult Congenital Heart Disease (MACHD) Registry

Conditions
-----------------
Healthy, Congenital Heart Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Capacity to Consent BMI </= 30 Systolic BP </= 140mmHg Diastolic BP </= 90 eGFR > 30 (within prior 3 months) to confirm kidney function Able to undergo an MRI Exclusion Criteria: History of Cardiovascular disease that may affect the results of the testing performed. Any Current orthopedic limitations Currently taking any cardiac medication Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pulmonary vascular reserve | The slope of mean pulmonary artery pressure / cardiac output (mPAP/CO) | Baseline |
Glottic Opening Percentage (POGO) With Miller and McGrath MAC Videoingoscopes

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to compare the percentage of glottic opening (POGO) with Miller and McGrath MAC Videoingoscopes compared to the direct epiglottis lifting method.

Detailed Description
-----------------
The aim of this study is to compare the percentage of glottic opening (POGO) with Miller and McGrath MAC Videoingoscopes compared to the direct epiglottis lifting method.

Official Title
-----------------
Comparison of Glottic Opening Percentage (POGO) With Miller and McGrath MAC Videoingoscopes According to Direct Epiglottis Lifting Method

Conditions
-----------------
Endotracheal intübation

Intervention / Treatment
-----------------
* Other: miller laryngoscope
* Other: McGrath MAC videolaryngoscope


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Those who agreed to participate in the study He will undergo elective surgery Endotracheal intubation required 18-65 years old ASA 1-2 risk Body mass index<30 No risk of difficult intubation Exclusion Criteria: Those who do not want to participate in the study, Allergic to study drugs, Pregnant women Those with a history of difficult intubation They will be applied rapid-serial intubation Emergency

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group M (n=42), Miller laryngoscope<br>The effect of direct epiglottis lifting method on the percentage of glottic patency in Miller and McGraht laryngoscopy. | Other: miller laryngoscope<br>* The percentage of glottic opening (POGO) will be evaluated according to the method of lifting the epiglottis (direct imaging).<br>|
| Group V (n= 43), McGrath MAC videolaryngoscope<br>The effect of direct epiglottis lifting method on the percentage of glottic patency in Miller and McGraht laryngoscopy. | Other: McGrath MAC videolaryngoscope<br>* The percentage of glottic opening (POGO) will be evaluated according to the method of lifting the epiglottis (direct imaging).<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of Glottic Opening Percentage (POGO) With Miller and McGrath MAC Videolaryngoscopes According to Direct Epiglottis Lifting Method | Comparison of Glottic Opening Percentage (POGO) With Miller and McGrath MAC Videolaryngoscopes According to Direct Epiglottis Lifting Method | during laryngoscopy | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
percentage of glottic opening, laryngoscopy, direct epiglottis lifting method
Effect of High Intensity Laser for Treatment Females With Fibromyalgia: Single Blinded Placebo-randomized Controlled

Study Overview
=================
Brief Summary
-----------------
This study will be conducted to investigate the effect of high intensity laser for treatment females with fibromyalgia

Official Title
-----------------
Effect of High Intensity Laser for Treatment Females With Fibromyalgia: Single Blinded Placebo-randomized Controlled

Conditions
-----------------
Fibromyalgia

Intervention / Treatment
-----------------
* Device: High Intensity Laser


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: WPI ≥ 7/19 pain sites and SSS ≥ 5/12 or WPI between > 3-6/19 and SSS > 9/12 symptoms have been present at a similar level for at least 3 months the patient does not have another disorder that would otherwise sufficiently explain the pain generalized pain, defined as pain in at least four of five regions, is present Exclusion Criteria: uncontrolled diabetes known history of cancer

Ages Eligible for Study
-----------------
Minimum Age: 25 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: High intensity laser
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: The laser probe - with the small spacer (3.1cm2) - was applied perpendicularly on the skin.<br> | Device: High Intensity Laser<br>* High Intensity Laser<br>|
| Experimental: Sham High intensity laser (HIL) on trigger points without output<br> | Device: High Intensity Laser<br>* High Intensity Laser<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain intensity | Numeric rating scale | up to 4 weeks |
The Effect of Telerehabilitation on Clinical Stress Level and Stress Responses in Nursing Students

Study Overview
=================
Brief Summary
-----------------
It was aimed to examine the effect of telerehabilitation on clinical stress level and stress responses in nursing students.

Detailed Description
-----------------
It was aimed to examine the effect of telerehabilitation on clinical stress level and stress responses in nursing students.There is no study in the literature examining the relationship between telerehabilitation and clinical stress in nursing students. Since our study will be the first to investigate the subject, we foresee that it is scientifically important and will shed light on future studies. In addition, national or international publications are planned after the study is completed.

Official Title
-----------------
The Effect of Telerehabilitation Practice on the Clinical Stress Level and Stress Responses of Nursing Students During Their First Clinical Experience

Conditions
-----------------
Stress

Intervention / Treatment
-----------------
* Other: Exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: to be between the ages of 18-24 to do the first clinical internship in the hospital Exclusion Criteria: have joint limitation have congenital anomaly have any orthopedic problem have any serious psychological problems

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 24 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: parallel assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: control group<br>The participants in the control group did not receive any intervention. | |
| Experimental: Exercise group<br>The participants in the exercise group performed Jacobson muscle relaxation exercises with a specialist physiotherapist through the Zoom program (https://zoom.us). The exercises were applied 4 days a week for 4 weeks. | Other: Exercise<br>* Muscle relaxing Technique<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perceived Stress Scale for Nursing Students | Sheu et al. (2002) originally in Chinese, the scale consists of 29 items.Total score; It ranges from 0 to 116. A high score indicates a high level of stress. The internal consistency coefficient value of the original scale is 0.86. | baseline and 4 weeks | 
| Biopsychosocial Response Scale of Nursing Students | The scale was developed by Sheu et al. (2002). There are 21 items in the scale.Total score; It ranges from 0 to 84 (sub-dimension total scores are 32, 28, and 24 points, respectively). High score indicates more symptom presence and poor bio-psycho-social status. | baseline and 4 weeks |
A Phase 2 Dose-finding Study of TS-172 in Hyperphosphatemia Patients on Hemodialysis

Study Overview
=================
Brief Summary
-----------------
A phase 2, randomized, placebo-controlled, double-blind, dose-finding study of TS-172 in hyperphosphatemia patients on hemodialysis

Official Title
-----------------
A Phase 2, Randomized, Placebo-controlled, Double-blind, Dose-finding Study of TS-172 in Hyperphosphatemia Patients on Hemodialysis

Conditions
-----------------
Hyperphosphatemia Patients on Hemodialysis

Intervention / Treatment
-----------------
* Drug: TS-172 10mg bid
* Drug: TS-172 30mg bid
* Drug: TS-172 60mg bid
* Drug: TS-172 20mg tid
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hyperphosphatemia patients (outpatients) with chronic kidney disease receiving hemodialysis (HD or HDF) 3 times a week for at least 12 weeks prior to Visit 1 (Week -4) Patients aged ≥18 to <80 years at the time of obtaining informed consent Patients with a serum phosphorus concentration of ≥ 3.5 mg/dL and ≤ 6.0 mg/dL at Visit 1 (Week -4) Exclusion Criteria: Patients with confirmed serum intact PTH concentration >500 pg/mL from Visit 1 (Week -4) to Visit 5 (Week 0) Patients with serum phosphorus concentration ≥ 10.0 mg/dL from Visit 2 (Week -3) to Visit 5 (Week 0) Patients who have undergone previous parathyroid intervention (PTx, PEIT, etc.)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 79 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 10 mg bid<br>Patients receive TS-172 10 mg bid. | Drug: TS-172 10mg bid<br>* oral administration of TS-172 10 mg bid<br>|
| Experimental: 30 mg bid<br>Patients receive TS-172 30 mg bid. | Drug: TS-172 30mg bid<br>* oral administration of TS-172 30 mg bid<br>|
| Experimental: 60 mg bid<br>Patients receive TS-172 60 mg bid. | Drug: TS-172 60mg bid<br>* oral administration of TS-172 60 mg bid<br>|
| Experimental: 20 mg tid<br>Patients receive TS-172 20 mg tid. | Drug: TS-172 20mg tid<br>* oral administration of TS-172 20 mg tid<br>|
| Placebo Comparator: Placebo<br>Patients receive placebo. | Drug: Placebo<br>* oral administration of placebo<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in serum concentration of phosphorus |  | Week 4 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Achievement ratio of patients with the target serum concentration of phosphorus |  | Up to Week 4 | 
| Concentration of corrected serum calcium |  | Up to Week 4 | 
| Serum calcium times phosphorus product |  | Up to Week 4 |
Clinical and Biochemical Features for the Identification of Dominant Calpainopathies

Study Overview
=================
Brief Summary
-----------------
Mutations in the CAPN3 gene cause muscular dystrophies with dysfunction in calpain-3. Calpainopathies are usually inherited in an autosomal recessive manner but in some families they can occur in a dominant inheritance. The significance of heterozygous variants is difficult to interpret in the absence of family history. In this study, the investigators will review the clinical and laboratory information in a cohort of patients identified in the participating centers, with the aim of improving the diagnostic strategy of dominant calpainopathies.

Detailed Description
-----------------
The investigators will review clinical and biomarker information in a cohort of 50 patients with heterozygous variants in the CAPN3 gene. Patients are referred by participating centers who will provide anonymised information on the clinical phenotype and laboratory test results. Suitable subjects will be contacted to obtain informed consent. Pseudonymised anamnestic data will be collected from the patient's clinical history and medical records.The aim is to identify a set of multidisciplinary data sufficient to define a diagnostic algorithm for the dominant calpainopathies.

Official Title
-----------------
Retrospective Analysis of Clinical and Biochemical Features for the Identification of Dominant Inheritance of Calpainopathies

Conditions
-----------------
Calpain-3 Deficiency Limb Girdle Muscular Dystrophy Type 2A

Intervention / Treatment
-----------------
* Other: retrospective study


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical LGMD phenotype, family history with dominant inheritance or sporadic cases, single variant in CAPN3, second variant excluded by MLPA (Multiplex Ligation Probe Amplification) or by analysis of mRNA extracted from muscle. Exclusion Criteria: No variants in CAPN3, two variants in CAPN3
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: retrospective study|data collection from clinical history and medical records|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle strenght | Evaluation of muscle strength with MRC Scale (score 1-5 from weaker to stronger) | through study completion, an average of 1 year | 
| Muscle biopsy | Evaluation of histology and calpain 3 expression (present, reduced, absent) | through study completion, an average of 1 year | 
| Creatin Kinase | Amount of creatine kinase in blood in units (U) of enzyme activity per liter (L) of serum | through study completion, an average of 1 year | 
| Clinical history | Data collection sheet from clinical records | through study completion, an average of 1 year |
Trabecular Bone Score in Multiple Sclerosis

Study Overview
=================
Brief Summary
-----------------
Assess bone quality in MS patients through TBS and evaluate the potential effects exerted by different drugs used in MS treatment, which may affect BMD and TBS in MS patients

Official Title
-----------------
Trabecular Bone Score (TBS) as an Innovative Parameter Evaluation for Bone Disease's in Multiple Sclerosis (MS) Patients and Impact of Osteoporosis on the Quality of Life of Patients With MS

Conditions
-----------------
Multiple Sclerosis, Endocrine System Diseases, Neurologic Disorder

Intervention / Treatment
-----------------
* Diagnostic Test: sm tbs group


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diagnosis of MS according to the latest revision of McDonald's criteria; patients with relapsing-remitting MS (RRMS), secondary progressive MS (SPMS) and primary progressive MS (SPMS); absence of cortisone therapy for at least 6 months; Exclusion Criteria: patients already being treated with anti-osteoporotic drugs; • medical conditions that preclude the execution of the densitometric examination

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| sm tbs group<br>All patients will undergo densitometric examination with dual-energy x-ray absorptiometry (DXA) technique at our Facility. | Diagnostic Test: sm tbs group<br>* After collecting anthropometric data, information on environmental factors and lifestyle (smoking, alcohol intake, physical activity, sun exposure, vitamin D supplementation, fish consumption) will be acquired through a questionnaire. The genetic and environmental aspects related to multiple sclerosis will also be studied. Disability status will be assessed through the Kurtzke Extended Disability Status Scale (EDSS). [10] All recruited patients will be administered the questionnaire (Multiple Sclerosis Quality of Life-54 (MSQOL-54) composed of 14 scales and 54 items. The scales investigate physical functions, limitations with respect to physical and emotional role, pain, emotional well-being, degree of energy, perceptions of one's health, social, cognitive and sexual functioning, distress, changes in health, satisfaction with sexual functioning and quality of life in general.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| DXA scanner (Horizon© DXA System) | The DXA scanner (Horizon© DXA System) measures bone mineral content relative to bone area. | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone Mineral Density | BMD will be measured in the lumbar spine (L2-L4) and in the right and left femoral neck and trochanter regions. | 6 months |