Common and Differentiated Representations Between Social Exclusion and Social Separation

Study Overview
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Brief Summary
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Explore the shared or separated neural mechanisms of social exclusion and social segregation and compare differential effects of AVP and OXT on these social interaction function.

Detailed Description
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A large body of research has shown that there are differences in the neural representation between social exclusion and social segregation, but the results are inconsistent, and the exploration of the neural basis is still insufficient. In addition, there are two mainstream theoretical explanations for these differences, namely the construction-level theory and the emotion-based theory, but there is no consistent theoretical model yet. Therefore, further exploration is necessary to confirm the cognitive and neural mechanisms underlying the differences between social exclusion and social segregation, and to attempt to reveal the theoretical explanations for these differences. In this project, the investigators propose to perform behavioral and functional magnetic resonance imaging (fMRI) techniques to examine the shared or separate neural mechanisms of social exclusion and social segregation (exp 1: social exclusion; exp 2: social separation) and investigate the modulatory effects of OXT/AVP on them (PLC/24IU OXT/20IU AVP).

Official Title
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Common and Differentiated Representations Between Social Exclusion and Social Separation

Conditions
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Healthy

Intervention / Treatment
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* Drug: Intranasal Oxytocin
* Drug: Intranasal Arginine Vasopressin
* Drug: Intranasal placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy subjects; Without any past or present psychiatric or neurological disorders; Without any current psychotherapeutic medication. EXclusion Criteria: With any past or present psychiatric or neurological disorders; With any current psychotherapeutic medication.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Randomized placebo-controlled double-blind between-subject design
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Intranasal Oxytocin<br>Administer oxytocin (24 IU) intranasally. | Drug: Intranasal Oxytocin<br>* Administer oxytocin (24 IU) intranasally, 6 individual 0.1 ml puffs (4 IU/0. 1ml), three puffs per nostril one every 30 seconds.<br>|
| Active Comparator: Intranasal Arginine Vasopressin<br>Administer Arginine Vasopressin (20 IU) intranasally. | Drug: Intranasal Arginine Vasopressin<br>* Administer arginine vasopressin (20 IU) intranasally, 6 individual 0.1 ml puffs (3.33 IU/0. 1ml), three puffs per nostril one every 30 seconds.<br>|
| Placebo Comparator: Intranasal placebo<br>Administer placebo intranasally. | Drug: Intranasal placebo<br>* Administer placebo intranasally, 6 individual 0.1 ml puffs, three puffs per nostril one every 30 seconds.<br>|
| No Intervention: Intranasal nothing (control)<br>Control condition | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neural index: OXT and AVP effects on fMRI based- social exclusion and social separation tasks | Comparions between OXT and AVP on social exclusion and social separation on brain activity or representations | 45 minutes after treatment administration | 
| Behavioral index: behavioral ratings of social exclusion and social separation tasks | Comparions between social exclusion and social separation in pain ratings | Immediately after fMRI scanning | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Social exclusion, Social separation, Oxytocin, Arginine Vasopressin, fMRI