Postoperative Effects of Propofol Versus Sevoflurane Anesthesia

Study Overview
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Brief Summary
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Background: The choice of appropriate anesthetics is essential to protect brain function, decrease perioperative complications, and provide high-quality care, and better quality of life. Objectives: To compare the efficacy and safety of propofol versus sevoflurane in patients undergoing elective, non-cardiac operations under general anesthesia. Methods: This was a randomized (1:1), parallel, phase four clinical trial; carried out on 44 patients, who were candidates for elective, non-cardiac operations under general anesthesia at our hospital. Patients were randomly allocated into two equal groups in which anesthesia was maintained with propofol infusion in group P and sevoflurane inhalation in group S.

Official Title
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Postoperative Effects of Propofol Versus Sevoflurane Anesthesia During Elective Non-Cardiac Surgeries. A Randomized Clinical Trial

Conditions
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General Anesthetic Drug Adverse Reaction

Intervention / Treatment
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* Drug: Propofol 10 MG/ML Injection
* Drug: Sevoflurane Inhalation Liquid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Society of Anesthesiologists (ASA) physical status ≤ II Age from 21 years Body Mass Index (BMI) 25-35 kg/m2 Exclusion Criteria: ASA physical status > II Age < 21 years Patients with Montreal Objective Cognitive Assessment (MoCA-B) score < 24 points Patients with significant cardiovascular, cerebrovascular, respiratory, liver, renal, endocrine, blood, or immune diseases Patients with visual or auditory disease, infection, chronic inflammation, disturbance of consciousness, cognitive impairment, or dementia Patients on long-term use of sedatives or steroids, alcohol or drug abuse Allergy to any of the study drugs

Ages Eligible for Study
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Minimum Age: 21 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group P (n=22)<br>Propofol group | Drug: Propofol 10 MG/ML Injection<br>* Propofol infusion<br>|
| Active Comparator: Group S (n=22)<br>Sevoflurane group | Drug: Sevoflurane Inhalation Liquid<br>* Sevoflurane inhalation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean and Standard deviation of Neuron Specific Enolase enzyme (µg/L) in blood serum (mean±SD) | Before operation (T0), 1 hour after the end of operation (T1), 24 hours the end of operation (T2) | 24 hours after the end of operation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cognitive function, General anesthesia, Inflammatory response, Oxidative stress, Propofol, Sevoflurane