Outcomes After PCI of the Aneurysmatic Right Coronary Artery

Study Overview
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Brief Summary
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This study aims to evaluate procedural and clinical outcomes of acute coronay syndrome (ACS) patients with aneurysmatic culprit right coronary artery (RCA).

Detailed Description
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The investigators sought differences in procedural (slow-flow, no-reflow, distal embolisation,Thrombolysis in Myocardial Infarction final flow (TIMI) etc.) and in immediate and long-term clinical outcomes between several subgroups such as index vs staged percutaneous coronary intervention (PCI), premedication vs none, use of IIb/IIIa inhibitors vs none, bare metal stent (BMS) vs drug eluting stent (DES), ultrathin DES vs thick DES, durable polymer vs bioresorbable or free polymer etc. The investigators also want to investigate the efficacy of different technical manoeuvres involved in resolving high thrombotic burden before stent deployment, such as thrombus aspiration, dilatation, intracoronary infusion of adenosine or thrombolytic agents, direct stenting etc.). Long-term follow-up includes target vessel failure (Cardiac Death, target vessel MI, clinically-driven target vessel revascularisation), define or probable stent thrombosis, target vessel revascularisation for ACS, clinically driven target vessel revascularisation and intrastent restenosis.

Official Title
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Percutaneous Coronary Interventions of the Aneurysmatic and Ectasic Right Coronary Artery in the Acute Setting: Management and Immediate- and Long-Term Outcomes The RIGHT-MARE Study

Conditions
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Coronary Disease, Coronary Artery Ectasia, Right Coronary Artery Occlusion, Right Coronary Artery Stenosis, STEMI

Intervention / Treatment
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* Procedure: Percutaneous Coronary Intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with ACS of the aneurysmatic or ectasic RCA Patient with at least 6 months clinical or angiographic follow-up Patients with accurate procedural and clinical records (particularly use of drugs before, during and after procedure, according to RCA PCI procedure (index or staged). Exclusion Criteria: Elective aneurysmatic or ectasic RCA PCI Patient with lack of accurate procedural and clinical data Patient with lack of clinical or angiographic follow up

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Index PCI<br>Patients with an aneurysmatic right coronary artery undergoing index PCI in the acute setting. | Procedure: Percutaneous Coronary Intervention<br>* Treatment of coronary stenoses with a drug-eluting stent or balloon<br>|
| Staged PCI<br>Patients with an aneurysmatic right coronary artery undergoing staged PCI in the acute setting. | Procedure: Percutaneous Coronary Intervention<br>* Treatment of coronary stenoses with a drug-eluting stent or balloon<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Technical success | Defined as final TIMI flow > 3 (TIMI 0: absence of any integrate flow beyond the coronary occlusion; TIMI 1: faint antegrade flow beyond the coronary occlusion with incomplete filling of the distal coronary bed; TIMI 2: delayed flow beyond the coronary occlusion with complete filling of the distal coronary bed; TIMI 3: normal flow with complete filling of the distal coronary bed) | Procedural (from the start to the end of the procedure) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Target Lesion Failure | Combination of cardiac death, target vessel MI and clinically target lesion revascularization | 12 moths | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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PCI, Acute Coronary Syndrome, Aneurysmatic Right Coronary Artery