linjc16/ctgov huggingface dataset:
Estimation of the Tissue and Serum Levels of Interleukin (IL) -35 in Mycosis Fungoides: a Case Control Study

Study Overview
=================
Brief Summary
-----------------
Tissue and serum samples from 20 MF patients and 20 normal healthy controls will be subjected for biochemical assessments by ELISA (Enzyme- linked immune-sorbent assay) for assessing the level of IL35.

Detailed Description
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Tissue and serum samples from 20 MF patients and 20 normal healthy controls will be subjected for biochemical assessments by ELISA (Enzyme- linked immune-sorbent assay) for assessing the level of IL35

Official Title
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Estimation of the Tissue and Serum Levels of Interleukin (IL) -35 in Mycosis Fungoides: a Case Control Study.

Conditions
-----------------
Mycosis Fungoides

Intervention / Treatment
-----------------
* Diagnostic Test: Skin biopsy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with mycosis fungoides. Both genders. Age group ≥ 18 years old. Exclusion Criteria: Patients with any other skin diseases. Patients who received treatments for mycosis fungoides in the past three months. Subjects with history of solid or hematological malignancy as leukemia

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Mycosis fungoides patients<br>Blood sample and skin biopsy for assessment of IL35 by ELISA | Diagnostic Test: Skin biopsy<br>* biochemical assessment for measurement IL35 by ELISA (Enzyme linked immunosorbent assay) technique in tissue and serum samples of all thirty patients and healthy controls.<br>* Other names: Blood sample;|
| Normal healthy controls<br>Blood sample and skin biopsy for assessment of IL35 levels by ELISA | Diagnostic Test: Skin biopsy<br>* biochemical assessment for measurement IL35 by ELISA (Enzyme linked immunosorbent assay) technique in tissue and serum samples of all thirty patients and healthy controls.<br>* Other names: Blood sample;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To assess and compare tissue and serum levels of interleukin 35 (IL -35) in mycosis fungoides patients and normal controls. | To assess and compare tissue and serum levels of interleukin 35 (IL -35) in mycosis fungoides patients and normal controls. | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlating tissue and serum levels of IL-35 in mycosis fungoides patients with patients age, sex, duration, extent and stage of the disease. L | Correlating tissue and serum levels of IL-35 in mycosis fungoides patients with patients age, sex, duration, extent and stage of the disease. | 1 year |
Consequence of Open Versus Closed Tracheostomy Immediately After Decannulation

Study Overview
=================
Brief Summary
-----------------
Tracheostomy is performed for prolonged mechanical ventilation. Ineffective bandaging following decannulation leaves the tracheostomy wound unsealed, reducing pulmonary function, coughing ability, and voice quality, ultimately leading to decannulation failure. Recently, a new concept enabling intratracheal sealing of the tracheotomy was introduced, potentially solving the issues of air leakage and tracheal wound infection. This study aims to investigate the feasibility of intratracheal tracheostomy sealing in relation to an immediate normalization of physiological airway flow and an improved voice quality.

Detailed Description
-----------------
See protocol document.

Official Title
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Consequence of Open Versus Closed Tracheostomy Immediately After Decannulation

Conditions
-----------------
Tracheostomy

Intervention / Treatment
-----------------
* Device: Sealing device
* Device: No device


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: Tracheostomy for minimum 7 days Age > 18 years Capped uncuffed tube size 7 or 8 for at least 24 hours Exclusion Criteria: Cognitive dysfunction (patients who are not able to cooperate with investigation)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sealed / closed tracheostomy<br>Sealing of the tracheostomy wound using a sealing device. | Device: Sealing device<br>* Intratracheal tracheostomy sealing<br>Device: No device<br>* Open tracheostomy wound<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lung function / air flow | Evaluated by spirometry | At time of decannulation, i.e. directly after inclusion and randomization to sealing or not as first intervention | 
| Voice quality | Evaluated by Equal-Appearing Interval Scale ranging from 1 to 5, where 5 represents a normal voice quality and 1 represents a severely impaired voice | At time of decannulation, i.e. directly after inclusion and randomization to sealing or not as first intervention | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
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tracheostomy, respiratory insufficiency, respiratory function tests, mechanical ventilators, rehabilitation, critical care
Frequency of Sexual Intercourse,Women With Fibromyalgia

Study Overview
=================
Brief Summary
-----------------
Does frequency of sexual intercourse affect symptom severity in female patients with fibromyalgia?

Official Title
-----------------
The Effect of Frequency of Sexual Intercourse on Symptoms in Women With Fibromyalgia

Conditions
-----------------
Fibromyalgia, Pain, Depression

Intervention / Treatment
-----------------
* Diagnostic Test: Fibromyalgia Impact Questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: * Female patient with fibromyalgia Exclusion Criteria: Uncontrollable systemic disease (cardiovascular, pulmonary, hepatic, renal, hematological), Major psychiatric disease, Endocrine disease, Pregnancy Menopausal status, Antihypertensive, antidepressant, anxiolytic, antiepileptic drugs use

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patient<br>female patient with fibromyalgia | Diagnostic Test: Fibromyalgia Impact Questionnaire<br>* diagnostic tests<br>* Other names: frequency of sexual intercourse;|
| healthy controls<br>women | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual Analog Scale | pain level 0-10, higher scores indicate worse outcome | 1 week | 
| frequency of sexual intercourse | mean monthly frequency of sexual intercourse in the last 3 months | 3 mounths | 
| Fibromyalgia Impact Questionnaire | 0-80, higher scores indicate worse outcome | 1 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Beck Depression Inventory | 0-63, higher scores indicate worse outcome | 1 week | 
| Widespread Pain Index | 0-19, higher scores indicate worse outcome | 1 week | 
| Symptom Severity Scale | 0-12, higher scores indicate worse outcome | 1 week |
Clinical Feasibility Assessment of Glean Urodynamics System

Study Overview
=================
Brief Summary
-----------------
The goal of this prospective observational trial is to assess the safety and reliability of the Glean Urodynamics System (GUS) in adult females with lower urinary tract symptoms. The main question[s] it aims to answer are: • What is GUS's ability to safely and reliably conduct wireless, catheter-free monitoring of vesical pressure compared to the vesical pressures collected with conventional urodynamics? Participants will undergo a conventional urodynamics exam, a simultaneous urodynamics exam with GUS, ambulatory urodynamics with GUS, and extended home monitoring with GUS. Researchers will compare GUS data with that from a conventional urodynamics exam.

Official Title
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Assessment of Clinical Feasibility and Safety of Wireless, Catheter-Free Glean Urodynamics System (GUS) in Adult Females With Lower Urinary Tract Symptoms (LUTS)

Conditions
-----------------
Urologic Diseases, Urodynamics

Intervention / Treatment
-----------------
* Device: Glean Urodynamics System


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female patients ages 18 years or older with a diagnosis of LUTS Scheduled for or recommended for conventional urodynamics Able to tolerate 18 Fr catheterization Able to provide informed consent Exclusion Criteria: Pregnant (as confirmed by urine pregnancy test) or breastfeeding, pregnant within the past 6 months or intend to become pregnant during the study period Has an active and symptomatic UTI (positive urine culture), or patient has an active and asymptomatic UTI (positive urine culture) and is not being treated prophylactically Diagnosed with neurogenic LUTD (i.e., known history of traumatic spinal cord injury, Parkinson's disease, multiple sclerosis, traumatic brain injury, or spina bifida) Has an atypical anatomic structural variation or has had a previous surgical intervention that has permanently changed structural anatomy anywhere along their lower urinary tract (urethra, pelvic floor, urethral sphincter, and/or bladder wall). Has a known inability to void or is in complete retention Who, at the principal investigator's determination, would not be appropriate for this study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Glean Urodynamics System|Wireless, catheter-free urodynamics system|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vesical pressure | Vesical pressure | during the procedure/surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Home Monitoring, Lower Urinary Tract Dysfunction, Urinary Incontinence, Overactive Bladder, Urodynamics, Uroflowmetry
Improvement Mental Health Among Physicians by a Mindfulness-training Mobile Application

Study Overview
=================
Brief Summary
-----------------
The aim of our study was to evaluate the effect of a short, smartphone-based mindfulness application on stress, wellbeing and burnout among hospital physicians

Detailed Description
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Physicians working at a tertiary hospital were recruited and randomly divided into two groups, a study group (SG) in which participants practiced mindfulness through the application for 6 weeks and a control group (CG). Main Measures: All participants filled-out questionnaires assessing stress (Perceived Stress Scale-PSS), mental health (Mental Health Inventory-MHI) and burnout (Maslach Burnout Inventory-MBI) at baseline and 7 weeks later

Official Title
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Improvement in Mental Health Markers Among Hospital Physicians Through a Mindfulness-training Mobile Application - Randomized Controlled Trial

Conditions
-----------------
Stress

Intervention / Treatment
-----------------
* Other: practiced mindfulness through the application for 6 weeks


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: * Physicians Working full-time at the Rambam Healthcare Campus. Exclusion Criteria: * Physicians that won't be able to participate in at least 50% of the practicing.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: a study group (SG) in which participants practiced mindfulness through the application for 6 weeks<br>a study group (SG) in which participants practiced mindfulness through the application for 6 weeks | Other: practiced mindfulness through the application for 6 weeks<br>* Physicians working at a tertiary hospital were recruited and randomly divided into two groups, a study group (SG) in which participants practiced mindfulness through the application for 6 weeks<br>|
| No Intervention: control group<br>Waiting for the intervention | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perceived Stress Scale-PSS | Differences in stress between baseline and 7 weeks later - will be assessed by Perceived Stress Scale-PSS | 7 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mental Health Inventory-MHI | Differences in Mental health between baseline and 7 weeks later will be assessed by Mental Health Inventory-MHI | 7 weeks | 
| Maslach Burnout Inventory - MBI | Differences in Burn out between baseline and 7 weeks later will be assessed by Maslach Burnout Inventory - MBI | 7 weeks |
Develop a Risk Prediction Model for Phthalate-ester-induced Diseases

Study Overview
=================
Brief Summary
-----------------
This exploratory study collected basic demographic and laboratory data from the Taiwan Biobank using artificial intelligence algorithms and applied data mining to identify the correlations between phthalate esters [di(2-ethylhexyl) phthalate, DEHP], lifestyle, and disease.

Detailed Description
-----------------
This study was designed as exploratory research. The Institutional Review Board and the Taiwan Biobank approved the study before it was conducted (Approval Number: TWBR11007-06). The data set included information from participants between 30 and 70 years old who were tested for PAEs between 2016 and 2022 (1337 cases). The data set includes (1) questionnaire responses, such as basic personal information, individual health behaviors, and female health issues; (2) physical examination results, such as body mass index (BMI), body fat percentage, waist circumference, hip circumference, waist-to-hip ratio, blood pressure, heart rate, pulmonary function, and bone mineral density; (3) blood and urine analyses results from blood tests, serology tests, hepatobiliary function tests, renal function tests, and urinalysis; and (4) data on PAE content of urine

Official Title
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Using Machine Learning Algorithms to Develop a Risk Prediction Model for Phthalate-ester-induced Diseases and Suggestions for Improved Nursing Assessment

Conditions
-----------------
Plasticizers

Participation Criteria
=================
Eligibility Criteria
-----------------
inclusion: The target subjects of this study are individuals aged 30 to 70 years old who were tested for PAEs from January 1, 2016 to December 31, 2020. exclusion: 1who have not been tested for plasticizers
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risk assessment analysis of disease and PAEs | (1) questionnaire responses, such as basic personal information, individual health behaviors, and female health issues; (2) physical examination results, such as body mass index (BMI), body fat percentage, waist circumference, hip circumference, waist-to-hip ratio, blood pressure, heart rate, pulmonary function, and bone mineral density; (3) blood and urine analyses results from blood tests, serology tests, hepatobiliary function tests, renal function tests, and urinalysis; and (4) data on PAE content of urine. | 2022 | 
| Artificial intelligence prediction model for diseases and PAEs | to apply machine learning to establish the correlations between the environmental hormone PAE and high disease risk and suggest assessment items for nursing intervention. | 2022 |
Comparison of Tele-rehabilitation Versus In-clinic Rehabilitation for Upper Limb Motor Function Stroke Patients

Study Overview
=================
Brief Summary
-----------------
To determine the effects of Tele-rehabilitation versus in-clinical rehabilitation for upper limb motor function and spasticity in chronic ischemic stroke patients.

Official Title
-----------------
Comparison of Effects of Tele-rehabilitation Versus In-clinic Rehabilitation for Upper Limb Motor Function in Chronic Stroke Patients

Conditions
-----------------
Stroke

Intervention / Treatment
-----------------
* Diagnostic Test: In-clinic Rehabilitation
* Diagnostic Test: Tele-rehabilitation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: • Patients from both genders. Patients with chronic ischemic stroke i.e. 6 months or more. Patients with 45 years old and above. On modified Ashworth scale, patient with limb spasticity equal to 2 or less than 2. On Mini Mental State Examination (MMSE), patients with good cognitive function minimum 24 or more. Exclusion Criteria: • Patients with any recurrent stroke history. Cognitive deficit patients (on Folstein Mini Mental state Examination score of less than 24) Patient having other neurological diseases.

Ages Eligible for Study
-----------------
Minimum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Tele-rehabilitation<br> | Diagnostic Test: Tele-rehabilitation<br>* Effects of Tele-rehabilitation for Upper Limb Motor Function in Chronic Stroke Patients<br>|
| Experimental: In-clinic Rehabilitation<br> | Diagnostic Test: In-clinic Rehabilitation<br>* Effects of In-clinic Rehabilitation for Upper Limb Motor Function in Chronic Stroke Patients<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fugal Myer assessment scale (FMAS) | Fugal Myer assessment scale (FMAS) to check the pain and funcationality in stroke | 6 Months | 
| Modified Ashworth Scale (MAS) | Modified Ashworth Scale (MAS) to check the pain and funcationality in stroke | 6 Months |
Upper Gastrointestinal Endoscopy Reporting System in Improving Report Quality

Study Overview
=================
Brief Summary
-----------------
The goal of this observational study is to evaluate the effectiveness of an AI-based reporting system for upper gastrointestinal endoscopy. The main question it aims to answer is: Whether the AI-based reporting system can improve the completeness of the reports, which are drafted by endoscopists with the AI assistance. Participants will undergo upper gastrointestinal endoscopy examination as routine. The junior endoscopists will draft the report with the assiatance of the AI system. And the senior and expert endoscopists will draft the report using the traditional reporting system without AI assistance.

Official Title
-----------------
A Prospective, Single-arm, Single-center Observational Study to Evaluate the Clinical Effectiveness of an Intelligent Reporting System for the Upper Gastrointestinal Endoscopy

Conditions
-----------------
Endoscopy, Gastrointestinal, Artificial Intelligence

Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: Aged 18 years Aim to undergo screening, surveillance, and diagnosis Undergo sedated EGD Able to read, understand, and sign informed consent Exclusion Criteria: EGD contraindications Not suitable for sedated endoscopy after anaesthesia evaluation Biopsy contraindications Active upper gastrointestinal bleeding or emergency oesophagogastroduodenoscopy (EGD) Pregnancy Upper gastrointestinal surgery or residual stomach Not suitable for recruitment after investigator evaluation because of other high-risk conditions

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Completeness of reporting lesions | Calculation method = number of report lesions / total number of lesions x 100% | one month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Completeness of report drafting on lesion features | Calculation method = number of drafted features of lesions / total number of features required to be drafted x 100% | one month | 
| Accuracy of report drafting on lesion features | Calculation method = number of accurately drafted features of lesions / total number of drafted features x 100% | one month | 
| Reporting time | The time that endoscopists draft reports | one month | 
| Completeness of reporting lesions of AI system | Calculation method = number of report lesions / total number of lesions x 100% | one month | 
| Accuracy of report drafting on lesion features of AI system | Calculation method = number of accurately drafted features of lesions / total number of drafted features x 100% | one month |