Simulated Walking With Multiplexing Prism for Field Expansion in Monocular Vision

Study Overview
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Brief Summary
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The investigators are developing an assistive device, known as multiplexing prism that expands the field of view for individuals with acquired monocular vision (loss of an eye). The investigators will test the efficacy of the prism in improving the detection of colliding pedestrians during a simulated walking task.

Official Title
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Monocular Visual Confusion for Field Expansion

Conditions
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One Eye Blindness, Blind Left Eye, Blind Right Eye

Intervention / Treatment
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* Device: Multiplexing Prism


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: No medical health issues such as seizures, motor movements problem Loss of vision in one eye (no light perception/enucleation/evisceration) for >1 year Visual acuity of the seeing eye: Better than 20/32 visual acuity with correction No visual field defect in the seeing eye (nasal field of at least >45degree) Exclusion Criteria: Patients with any physical or mental disabilities, including cognitive dysfunction, balance problems, or other deficits that could impair their ability to respond to the stimuli presented in this study will be excluded Any person with a history (such as pacemaker use or photosensitive epilepsy) Any person with motor movements problem (e.g., unable to use extremities)

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Interventional Model Description: Individuals with Acquired Monocular Vision/ Blindness in One Eye
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Detection of colliding pedestrian<br>Participants will perform a simulated walking task in which surrounding pedestrians will walk towards and make a collision. Participants will respond by pressing buttons to indicate the direction of the colliding pedestrians. Participants will perform the task with and without the multiplexing prism in random orders. | Device: Multiplexing Prism<br>* Multiplexing prism is designed for spatial vision multiplexing. It allows partial light transmission through the prism allow the observer to simultaneously see the physical world through the prism and see the shifted view from the non-seeing side. It is developed to expand the field of view of individuals with just one eye.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean response time to detect colliding pedestrian | The investigators will compare the mean response time to detect colliding pedestrians coming from the nasal (same side as the blind eye) and temporal (same side as the seeing eye) visual field with and without multiplexing prism. The comparison will be made between these four: Nasal without prism, Temporal without prism, Nasal with prism, and Temporal with prism. | Approximately 3 sessions, up to 3 hours for each session, any time within 4 month period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pedestrian Detection Rate | The investigators will measure the rate of correct detection rate of colliding pedestrians in the nasal (same side as the blind eye) and temporal (same side as the seeing eye) with and without multiplexing prism. Comparisons will be made for these: nasal without prism, temporal without prism, nasal with prism,and temporal with prism. | Approximately 3 sessions, up to 3 hours for each session, any time within 4 month period | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Simulated Walking, Collision, Field Expansion, One eye blindness