Evaluating the Episodic Future Thinking Intervention for Reducing Cigarette Consumption in Cigarette Smokers

Study Overview
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Brief Summary
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This clinical trial evaluates the effectiveness of active episodic future thinking (EFT) stimuli for reducing cigarette consumption in cigarette smokers. EFT is an innovative framing method shown to significantly activate brain regions involved in future thinking, planning, and other executive functions. Active EFT stimuli are positive events, unrelated to smoking, that participants anticipate, look forward to, and can vividly imagine happening up to 1 year in the future. Control EFT stimuli are positive past events, unrelated to smoking, that participants can vividly remember happening in the recent past. Active EFT stimuli may help reduce cigarette consumption among cigarette smokers by exposing them to personally relevant future oriented stimuli.

Detailed Description
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PRIMARY OBJEECTIVE: I. To evaluate the efficacy of episodic future thinking (EFT) for smoking cessation. OUTLINE: Participants are randomized to 1 of 2 arms. ARM I (ACTIVE): Participants receive the active EFT stimulus and use the iCOquit Smokerlyzer carbon monoxide monitor on study. ARM II (CONTROL): Participants receive the control EFT stimulus and use the iCOquit Smokerlyzer carbon monoxide monitor on study.

Official Title
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Pilot Study of Episodic Future Thinking Among Cigarette Smokers

Conditions
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Cigarette Smoking-Related Carcinoma

Intervention / Treatment
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* Behavioral: Smoking Cessation Intervention
* Behavioral: Smoking Cessation Intervention (control)
* Other: Medical Device Usage and Evaluation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Smoke >= 10 cigarettes daily > 32 on the Vividness of Visual Imagery Questionnaire (VVIQ) No regular use of other tobacco products In possession of a smartphone with text messaging capabilities Exclusion Criteria: Unable or unwilling to provide verbal consent Unable or unwilling to provide data to the research team Current use of nicotine replacement therapy, bupropion, or varenicline Use of drugs of abuse in the past 30 days Living in the same household as a participant already enrolled in this study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Arm 1 (active EFT)<br>Participants receive the active EFT stimulus and use the iCOquit Smokerlyzer carbon monoxide monitor on study. | Behavioral: Smoking Cessation Intervention<br>* Receive active EFT stimulus<br>* Other names: Smoking and Tobacco Use Cessation Interventions;Other: Medical Device Usage and Evaluation<br>* Use iCOquit Smokerlyzer carbon monoxide monitor<br>|
| Active Comparator: Arm II (control EFT)<br>Participants receive the control EFT stimulus and use the iCOquit Smokerlyzer carbon monoxide monitor on study. | Behavioral: Smoking Cessation Intervention (control)<br>* Receive control EFT stimulus<br>* Other names: Smoking and Tobacco Use Cessation Interventions;Other: Medical Device Usage and Evaluation<br>* Use iCOquit Smokerlyzer carbon monoxide monitor<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Concentration of carbon monoxide on breath | Will be measured by ICOquit Smokerlyzer | From baseline up to 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction in delay discounting rate | participants will be guided to imagine the situational and sensory details for each of the stimuli until the vividness scores are ≥ 4 on a scale of 1-5 (1=very low, 5=very high). | Up to 30 days |