Machine Vision Based MDS-UPDRS III Machine Rating

Study Overview
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Brief Summary
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The Movement Disorders Society (MDS) Unified Parkinson's Disease Rating Scale (UPDRS) Part III (MDS-UPDRS III) is the primary assessment method for motor symptoms in Parkinson's disease patients. Currently, movement disorder specialists conduct semi-quantitative scoring, which entails limitations such as subjectivity, weak sensitivity, and a limited number of professional physicians. This study, based on machine vision, establishes gold standard labels according to expert scoring. By using machine learning, we develop a machine rating model and compare the model's performance with gold standard rating and general clinical rating to investigate the accuracy of machine vision-based MDS-UPDRS III machine rating.

Official Title
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Machine Vision Based Machine Rating of MDS-UPDRS III

Conditions
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Parkinsonian Disorders, Machine Learning

Intervention / Treatment
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* Other: video recording


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Meeting the diagnostic criteria for Parkinsonism established by the International Movement Disorder Society: having bradykinesia, and meeting at least one of the two criteria for resting tremor or muscle rigidity 20 to 80 years old Good compliance, voluntarily joining the study, and able to sign an informed consent form or have it signed by a legal representative Exclusion Criteria: Significant cognitive impairment (MMSE ≤ 23) Unable to sign written informed consent or unable to complete the trial due to other reasons Other situations in which the researcher deems the participant unsuitable for this study Participation in other clinical trials

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: video recording|Patients' performance of MDS-UPDRS III will be recorded.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ACC0 of machine rating vs gold standard rating | The accuracy rate when machine rating equals gold standard rating. | 1 day | 
| ACC1 of machine rating vs gold standard rating | The accuracy rate when machine rating equals the range of gold standard rating plus or minus one. | 1 day | 
| Weighted kappa of machine rating vs gold standard rating | The weighted kappa when machine rating equals gold standard rating. | 1 day | 
| Lin's CCC of machine rating vs gold standard rating | The Lin's Concordance Correlation Coefficient when machine rating equals gold standard rating. | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Accuracy rate of machine rating vs general clinical rating | Comparing the absolute residuals between machine rating and the gold standard rating with the absolute residuals between general clinical raitng and the gold standard rating. | 1 day | 
| Accuracy rate of machine facilitated rating vs general clinical rating | Comparing the absolute residuals between machine facilitated rating and the gold standard rating with the absolute residuals between general clinical raitng and the gold standard rating. | 1 day |