Ventricular Tachycardia Ablation in LVAD Patients

Study Overview
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Brief Summary
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The CHANNELED-Registry is a multicenter retrospective study to (1) systematically assess the mechanism and origin of ventricular tachycardia in patients with end-stage heart failure carrying an left ventricular assist device (LVAD) and (2) to evaluate procedural parameters and outcome of ventricular tachycardia ablation in this special subset of patients.

Official Title
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Characterization of Ventricular Tachycardia Ablation in End-stage Heart Failure Patients With Left Ventricular Assist Device

Conditions
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Ventricular Tachycardia, End-stage Heart Failure, Ventricular Arrythmia, LVAD (Left Ventricular Assist Device)

Intervention / Treatment
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* Other: Ablation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients with end-stage heart failure with an LVAD implanted undergoing VT ablation Exclusion Criteria: Patients <18 years, pregnant women, patients undergoing VT ablation without an LVAD

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| LVAD patients<br>Patients with end-stage heart failure with an LVAD implanted undergoing VT ablation. | Other: Ablation<br>* VT ablation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mechanism of ventricular tachycardia in LVAD patients (descriptive name of scale) | Assessment of the mechanism of VT in LVAD patients (e.g LVAD cannula related vs. related to substrate of underlying heart disease) | 12 month | 
| Number of patients with ventricular tachycardia recurrence in device interrogation (physiological parameter) | Assessment of VT recurrence after ablation: Device interrogation and readout of ICD Holter | 12 month | 
| Mortality (physiological parameter) | Assessment of mortality after VT ablation. | 12 month | 
| Heart failure Hospitalization (physiological parameter) | Assessment of Hospitalization for worsening of Heart Failure after VT ablation. | 12 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Procedure duration (From groin puncture to sheath removal in minutes) | Evaluation of the duration of VT ablation procedures in LVAD patients | 12 month | 
| Fluoroscopy time (minutes) | Evaluation of the fluroscopy use (in minutes) | 12 month | 
| Radiofrequency energy used for ablation (in watts; e.g. 40 Watts) | Evaluation of the maximum RF-energy used for ablation | 12 month | 
| Number of patients suffering from intraprocedural complication (physiological parameter, e.g. hematoma) | Evaluation of intraprocedural complications of VT ablation | 12 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Catheter Ablation, VT Ablation in LVAD patients