MDMA-assisted Massed Prolonged Exposure for PTSD

Study Overview
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Brief Summary
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The overall objective of this study is to pilot the VASDHS-adapted Emory MDMA-PE Protocol (aE-MDMA-PE) and assess the effect on clinician-rated PTSD symptoms in veterans who receive full-dose MDMA and veterans who receive low-dose MDMA.

Detailed Description
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The study is a randomized pilot study that will evaluate the preliminary efficacy, safety, tolerability, and acceptability of the intervention in a sample of U.S. veterans seeking PTSD treatment at the VASDHS. Ten veterans will be randomized in a 1:1 ratio to receive MDMA in a standard dose (120 mg MDMA HCl,  102 mg MDMA, rounded) or low dose (40 mg MDMA HCl,  34 mg MDMA) based on the 2-week Emory MDMA-PE Protocol developed by Maples-Keller and Rothbaum. The current protocol will entail massed-PE and the MDMA administration spanning up to 3-weeks. PE will involve eleven 90-minute sessions with the initial two sessions both occurring during the first treatment visit and the remaining sessions occurring daily or every other day (M-F for two to three weeks). Following the baseline assessment during Visit 1, participants will begin PE during Visit 2, which will include psychoeducation, rationale for exposure-based treatment, discussion of the SUDS scale, and creating the in vivo exposure hierarchy. Visit 3 will include the first imaginal exposure. Participants will report SUDS at the start and end of imaginal exposure. Imaginal exposures will be recorded, and participants will listen to this recording as homework. Following a modified version of the MAPS Preparatory session criteria, we also will provide psychoeducation regarding MDMA's subjective effects and strategies for MDMA-related support after a 30-minute break following the PE session. Visit 4 will include the MDMA administration. At the beginning of Visit 5, following a modified version of the MAPS Integration session criteria, the therapist and patient will focus on developing a deeper understanding of insights from the MDMA session and any thoughts or feelings regarding the patient's experience of PTSD and its impact on their life. After the Integration session there will be a 30-minute break before the PE session. Visits 5-12 will include imaginal exposures and processing of the in-session experience. Each day an in vivo exposure will be assigned for homework; all sessions will begin with a check-in that includes reviewing this exposure experience. The post-treatment questionnaire assessment will occur on Visit 13. Participants will complete post-treatment follow-up CAPS-5 clinical interviews remotely within 1 week, 2 months, and 4 months after treatment.

Official Title
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MDMA-assisted Massed Prolonged Exposure for PTSD

Conditions
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Post-Traumatic Stress Disorder

Intervention / Treatment
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* Drug: 3,4 Methylenedioxymethamphetamine
* Behavioral: Prolonged Exposure


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Be a veteran (age 18 years or older) who meets criteria for PTSD due to any military event on the CAPS-5 (severity ≥ 25). Be fluent in speaking and reading English. Are willing to commit to medication dosing, therapy sessions, follow-up sessions, completing evaluation instruments, and all necessary telephone contact Be able to swallow pills. Agree to have study visits audio and/or video recorded, including MDMA session, assessments, and PE sessions, and aware that Independent Rater assessments for PE sessions will occur. Have a contact able to drive the participant home after the MDMA session. Provide a contact (relative, spouse, close friend, or other support person) who is willing and able to be reached by the investigators in the event of a participant becoming suicidal or unreachable. Agree to inform the investigators within 48 hours of any new medical conditions or procedures. If able to become pregnant (i.e., assigned female at birth, fertile, following menarche and until becoming post-menopausal unless permanently sterile), must have a highly sensitive negative pregnancy test at study entry and prior to the MDMA session, and must agree to use adequate birth control for 1 month before through 10 days after the MDMA session. Adequate birth control methods include intrauterine device (IUD), injected, implanted, intravaginal, or transdermal hormonal methods, abstinence, oral hormones plus a barrier contraception, vasectomized sole partner, or double barrier contraception. Two forms of contraception are required with any barrier method or oral hormones (i.e., condom plus diaphragm, condom or diaphragm plus spermicide, oral hormonal contraceptives plus spermicide or condom). Agree to the following lifestyle modifications (described in more detail in Section 3.3 Lifestyle Modifications): comply with requirements for fasting and refraining from certain medications prior to and following the MDMA session, including a possible medication taper if on SSRIs, medications for ADHD, and/or other medications described in the concomitant medications section. Agree not to participate in other PTSD psychotherapy during study treatment. Not enroll in any other interventional clinical trials during the duration of the study, and commit to medication dosing, therapy, and study procedures. At Screening, have at least moderate PTSD symptoms in the last month based on PCL-5 total score of 40 or greater (index). May have well-controlled hypertension that has been successfully treated with anti- hypertensive medicines if they pass additional screening to rule out underlying cardiovascular disease. May have asymptomatic Hepatitis C virus (HCV) that has previously undergone evaluation and treatment as needed. May have alcohol or substance use disorder if participant is not in withdrawal or requiring detox. Participants must have a plan, agreed upon by investigator, therapy team, and study physician, to reduce use of alcohol or other substances and to manage symptoms without self-medicating. Enrollment will require that, in the judgment of the investigator, therapy team, and study physician, the plan for decreasing substance use is realistic and has a good chance of succeeding in order to prevent substance use from impacting the safety or effectiveness of the investigational treatment. Veterans will also be subject to a urine toxicology drug screening prior to enrollment and before the MDMA session. May have a history of or current Diabetes Mellitus (Type 2) if additional screening measures rule out underlying cardiovascular disease, if the condition is judged to be stable on effective management, and with approval by the study physician. May have hypothyroidism if taking adequate and stable thyroid replacement medication. May have a history of, or current, glaucoma if approval for study participation is received from an ophthalmologist. Exclusion Criteria: Are not able to give adequate, written informed consent. Are currently engaged in compensation and pension (C&P) litigation whereby financial gain would be achieved from prolonged symptoms of PTSD or any other psychiatric disorders. Are likely, in the investigator's opinion and via assessment period, to be re- exposed to their index trauma or other significant trauma, lack social support, or lack a stable living situation. Have used Ecstasy (material represented as containing MDMA) more than 10 times within the last 10 years or at least once within 6 months of the MDMA session. Have a positive screen for amphetamine or cocaine. Have any current problem which, in the clinical opinion of the investigator and study physician, might interfere with participation due to it impacting the patient's safety and/or ability to participate in the protocol. Have hypersensitivity to any ingredient of the IMP (Investigational Medicinal Product). Have received Electroconvulsive Therapy (ECT) within 12 weeks of enrollment. Have dementia. Have a history of or a current primary psychotic disorder assessed via the DIAMOND and clinical interview. Have a history of or current Bipolar 1 disorder, Bipolar 2 disorder, or manic episode assessed via the DIAMOND and clinical interview. Have a current eating disorder with active purging assessed via DIAMOND and clinical interview. Have current major depressive disorder with psychotic features assessed via DIAMOND. Have a current panic disorder assessed via the DIAMOND Have a history of amphetamine or cocaine substance use disorder Have a current alcohol or substance use disorder other than caffeine or nicotine that the investigators, therapy team, and/or study physician judge to be a safety concern for enrollment in the study or that could interfere with the therapeutic process or with other aspects of study participation. Any participant who is not able to agree or adhere to a plan to reduce use and manage symptoms will not be enrolled. Individuals endorsing severe symptoms of an active alcohol use disorder (AUDIT >8 for men, >6 for women) or of an active substance use disorder (DUDIT >6 for men, >2 for women) will be evaluated by the study PI and/or physicians to determine if they should be excluded. Present with current serious suicide risk, as determined through psychiatric interview, responses to C-SSRS (scores of four or greater), and clinical judgment of the investigator; however, history of suicide attempts is not an exclusion. Any participant who is likely to require hospitalization related to suicidal ideation and behavior, in the judgment of the investigator, will not be enrolled. Any participant presenting with the following on the pre-screen C-SSRS will be excluded: Suicidal ideation score of 4 or greater within the last 6 months of the assessment at a frequency of once a week or more. Any suicidal behavior, including suicide attempts or preparatory acts, within the last 6 months of the assessment. Participants with non-suicidal self- injurious behavior may be included if approved by the study physician. Would present a serious risk to others as established through clinical interview and if necessary, discussion with treating psychiatrist. Require ongoing concomitant therapy with a psychiatric medication other than the exceptions described in protocol section on Concomitant Medications. Have a history of any medical condition that could make receiving a sympathomimetic drug harmful because of increases in blood pressure and heart rate. This includes, but is not limited to, a history of myocardial infarction, cerebrovascular accident, or aneurysm. Participants with other mild, stable chronic medical problems may be enrolled if the study physician and PI agree the condition would not significantly increase the risk of MDMA administration or be likely to produce significant symptoms during the study that could interfere with study participation or be confused with side effects of the IMP. Examples of stable medical conditions that could be allowed include, but are not limited to Human Immunodeficiency Virus (HIV) infection, Gastroesophageal Reflux Disease (GERD), etc. Any medical disorder judged by the investigator to significantly increase the risk of MDMA administration by any mechanism would require exclusion. Have a diagnosis of uncontrolled hypertension defined by the American Heart Association as repeated readings of ≥ 140 millimeters of Mercury [mmHg] systolic or ≥ 90 mmHg diastolic. Have a history of ventricular arrhythmia at any time, other than occasional premature ventricular contractions (PVCs) in the absence of ischemic heart disease. Have Wolff-Parkinson-White syndrome or any other accessory pathway that has not been successfully eliminated by ablation. Have a history of arrhythmia, other than premature atrial contractions (PACs) or occasional PVCs in the absence of ischemic heart disease, within 12 months of screening. Participants with a history of atrial fibrillation, atrial tachycardia, atrial flutter or paroxysmal supraventricular tachycardia or any other arrhythmia associated with a bypass tract may be enrolled only if they have been successfully treated with ablation and have not had recurrent arrhythmia for at least one year off all antiarrhythmic drugs and confirmed by a cardiologist. Have a marked Baseline prolongation of QT/QTc interval. For purposes of eligibility, this is defined as repeated demonstration of a QT interval corrected using Fridericia's formula [QTcF] >450 milliseconds [ms]. Have a history of additional risk factors for Torsade de pointes (e.g., heart failure, hypokalemia, family history of Long QT Syndrome). Require use of concomitant medications that prolong the QT/QTc interval during Sessions. Refer to protocol section on Concomitant Therapy. Have symptomatic liver disease or have repeated significant liver enzyme elevations on labs. Have history of hyponatremia or hyperthermia. Weigh less than 48 kilograms (kg). Are pregnant or nursing or are able to become pregnant and are not practicing an effective means of birth control. Have engaged in ketamine-assisted therapy or used ketamine within 12 weeks of enrollment. Have any preexisting condition affecting renal functioning.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Eligible participants will be randomized in a stratified 1:1 manner to the standard dose MDMA or low dose MDMA condition.
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Standard Dose<br>Non-medicine sessions of PE + One Medicine Session with 3,4-methylenedioxymethamphetamine (MDMA) PE Non-medicine sessions: 11 sessions MDMA Medicine session: Standard Dose: 120 mg MDMA HCl ( 102 mg MDMA) | Drug: 3,4 Methylenedioxymethamphetamine<br>* 1 MDMA session<br>* Other names: MDMA;Behavioral: Prolonged Exposure<br>* 11 90-minute PE sessions; initial two sessions both occurring during the first treatment visit and the remaining sessions occurring daily or every other day<br>* Other names: PE;|
| Experimental: Low Dose<br>Non-medicine sessions of PE + One Medicine Session with 3,4-methylenedioxymethamphetamine (MDMA) PE Non-medicine sessions: 11 sessions MDMA Medicine session: Low Dose: 40 mg MDMA HCl ( 34 mg MDMA) | Drug: 3,4 Methylenedioxymethamphetamine<br>* 1 MDMA session<br>* Other names: MDMA;Behavioral: Prolonged Exposure<br>* 11 90-minute PE sessions; initial two sessions both occurring during the first treatment visit and the remaining sessions occurring daily or every other day<br>* Other names: PE;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinician-rated PTSD symptoms | The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) is a 20-item diagnostic interview administered by trained evaluators to assess PTSD in a participant. Based on DSM-5 diagnostic criteria, evaluators ask about the severity of four PTSD-related symptom clusters: re-experiencing, avoidance, negative alterations in cognition and mood, and alterations in arousal and reactivity. The evaluator rates responses on a 5-point Likert scale (0 = Absent to 4 = Extreme/Incapacitating). Total scores range from 0 to 80 with higher scores indicating greater severity. | Baseline - 4-months post-treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Self-reported PTSD symptoms | The PTSD Checklist for DSM-5 (PCL-5) is a 20-item self-report questionnaire in which respondents indicate the presence and severity of PTSD symptoms. Participants indicate how much distress they have experienced due to symptoms on a five-point Likert-type scale (1=Not at all to 5=Extremely). Total scores range from 0 to 80, with higher scores indicating more severe PTSD symptoms. | Baseline - 4-months post-treatment | 
| Depressive Symptoms | The Patient Health Questionnaire 9 (PHQ-9) is a 9-item self-report measure of depressive symptoms. The PHQ-9 screens for major depression, with a score of 10 or above indicative of a possible major depressive episode, and it provides a measure of severity of these symptoms. | Baseline - 4-months post-treatment | 
| Functioning | The Brief Inventory of Psychosocial Functioning (B-IPF) is a brief version of the Inventory of Psychosocial Functioning (IPF) that measures functioning impairment across seven domains: intimate relationships, family and parenting, friendships, work, socializing, education, and self-care over the past 30 days. Total scores, ranging from 0 to 100, are calculated as the sum score divided by the total possible score multiplied by 100, with higher scores indicating greater impairment in functioning. | Baseline - 4-months post-treatment | 
| Sleep | The Pittsburgh Sleep Quality Index (PSQI) measures sleep quality over the past 1-month using 19 items in a self-report questionnaire format. The scale has seven subcategories: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medication, and daytime dysfunction. Items are rated on a combination of Likert scales from 0 to 3 and open- ended questions that are later converted to scaled scores.. Higher total scores indicate greater sleep disturbance. | Baseline - 4-months post-treatment | 
| Safety/Suicidality | The C-SSRS is a clinician-administered measure of suicidal behavior devised to detect potential suicidal thoughts or behaviors during a clinical trial. It consists of a Baseline version and a Since Last Visit version that assess suicidal ideation, ideation intensity, and behavior. | Baseline - 4-months post-treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MDMA, Post Traumatic Stress Disorder, 3,4-methylenedioxymethamphetamine, Veterans, Prolonged Exposure Therapy