Mechanisms of LV Remodeling in Hypertensive Patients Working on a Rotational Expeditionary Basis in the Arctic

Study Overview
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Brief Summary
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The main goal of our investigation is to study the mechanisms of formation of left ventricular remodeling in patients with hypertension, working on a rotational expedition basis in the Arctic.

Detailed Description
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Hypothesis: In patients with hypertension working in the conditions of the Arctic shift, the combination of climatic and geographical factors and rotational expeditionary method of labor contributes to the increase in the left ventricular remodeling processes and leads to the formation of heart failure with preserved ejection fraction.

Official Title
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Mechanisms of Left Ventricular Remodeling in Hypertensive Patients Working on a Rotational Expeditionary Basis in the Conditions of the Arctic Region

Conditions
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Heart Failure With Preserved Ejection Fraction

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patient signed the informed consent Exclusion Criteria: Valvular pathology of the heart Past cardiac or cerebral complications Identified heart rhythm disturbances Coronary heart disease Patients with severe somatic pathology, whose prognostic survival rate does not exceed 1 year The presence of a mental disorder of organic origin

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with hypertension of stages 1 and 2<br>Individuals with stage 1 and 2 hypertension living in a temperate climate zone and doing rotational shiftwork in the Arctic. | |
| Healthy volunteers<br>Virtually healthy individuals living in a temperate climate zone and and doing rotational shiftwork in the Arctic. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Echocardiographic assessment of GLS (Global longitudinal strain), % | Echocardiographic assessment of global strain (%) at baseline and after one year of follow-up. | One year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Myeloperoxidase, ug/ml | Biomarker of oxidative stress; Lab analyzer - Stat Fax 4200 (USA); | One year | 
| Oxidized low density lipoproteins | Biomarker of oxidative stress; Lab analyzer - Stat Fax 4200 (USA) | One year | 
| Homocysteine, umol/l | Biomarker of oxidative stress; Lab analyzer - IMMULITE 2000 (Siemens Diagnostics, USA); | One year | 
| C-reactive protein, IU/L | Biomarker of immune inflammation; Lab analyzer - Stat Fax 4200 (USA); | One year | 
| Tumor necrosis factor alpha, pg/ml | Biomarker of immune inflammation; Lab analyzer - Stat Fax 4200 (USA); | One year | 
| 1,6,8 interleukins, pg/ml | Biomarker of immune inflammation; Lab analyzer - Stat Fax 4200 (USA); | One year | 
| GDF-15/MIC-1 (Growth Differentiation Factor 15/Macrophage-inhibitory 1), pg/ml | Biomarker of fibrosis; Lab analyzer - Stat Fax 4200 (USA); | One year | 
| PIIINP (N-terminal propeptide to procollagen III), ng/ml | Biomarker of fibrosis; Lab analyzer - Stat Fax 4200 (USA); | One year | 
| FGF-23 (Fibroblast growth factor 23), pmol/l | Biomarker of fibrosis; Lab analyzer - Stat Fax 4200 (USA); | One year | 
| Plasma procollagen type 3 | Biomarker of remodeling factors; Lab analyzer - Stat Fax 4200 (USA); | One year | 
| Adrenaline, pg/ml | Catecholamine; Lab analyzer - Stat Fax 4200 (USA); | One year | 
| Noradrenaline, pg/ml | Catecholamine; Lab analyzer - Stat Fax 4200 (USA); | One year | 
| Testosterone, nmol/l | Hormone; Lab analyzer - Stat Fax 4200 (USA); | One year | 
| Progesterone, nmol/l | Biomarker of hormones; Lab analyzer - Stat Fax 4200 (USA); | One year | 
| Estradiol, pg/ml | Hormone; Lab analyzer - Stat Fax 4200 (USA); | One year | 
| Cystatin-C, ng/ml | Biomarker of chronic kidney disease; Lab analyzer - Stat Fax 4200 (USA); | One year | 
| NGAL (Neutrophilic gelatinase-associated lipocalin or neutrophilic lipocalin), ng/ml | Biomarker of chronic kidney disease; Lab analyzer - Stat Fax 4200 (USA); | One year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hypertension, Arctic, rotational shift work, echocardiography