Interstitial Lung Disease and Obstructive Sleep Apnea

Study Overview
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Brief Summary
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Clinically, all patients with interstitial lung disease were observed, and relevant clinical data were collected. Bronchoscopic specimens were collected according to the condition of the enrolled patients, and the ROSE smear was evaluated, combined with the NGS results of these patients. To observe the etiology and biological characteristics of exacerbation in patients with interstitial lung disease. Patients with apnea should be tested for polysomnography, and corresponding biological specimens should be obtained for molecular biology or other tests

Official Title
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Study on the Clinical Characteristics of Interstitial Lung Disease and Obstructive Sleep Apnea

Conditions
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ILD OSA

Intervention / Treatment
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* Diagnostic Test: The relationship between imaging and ROSE and NGS


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: over 18 years old and under 80 years old. Clinical diagnosis of interstitial lung disease or obstructive respiratory sleep apnea syndrome. Patient is conscious and capable of signing informed consent. The patient may wear a polysomnograph. Exclusion criteria: malignant tumors. severe heart failure. uremia. autoimmune diseases. pulmonary embolism, and end-stage chronic obstructive pulmonary disease. Patients with mental illnesscannot sign informed consent on their own.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| OSA group<br>Sleep detection was performed in OSA patients，And according to the severity of the analysis, obtain the corresponding biological specimens, the relevant detection | Diagnostic Test: The relationship between imaging and ROSE and NGS<br>* The correlation between ROSE and NGS in imaging and bronchoscopy of ILD patients was observed<br>* Other names: Association between the severity of OSA and biological specimen examination;|
| Interstitial lung disease group<br>Bronchoscopy was performed to obtain alveolar lavage fluid in ILD patients and lung tissue was obtained for ROSE and NGS in appropriate patients | Diagnostic Test: The relationship between imaging and ROSE and NGS<br>* The correlation between ROSE and NGS in imaging and bronchoscopy of ILD patients was observed<br>* Other names: Association between the severity of OSA and biological specimen examination;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| imaging changes and ROSE and NGS in patients | Relationship between imaging changes and ROSE and NGS in patients with interstitial lung disease | 2Day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Severity and biological examination of OSA patients | Classification of the severity of OSA and the relationship between positive results of biological or other tests | 2Day |