Brain Imaging in Cerebral Venous Outflow Disturbance

Study Overview
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Brief Summary
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Cerebral venous outflow disturbance can lead to cerebral hemodynamic disturbances, altered cerebrospinal fluid dynamics, cerebral venous blood stasis, increased cerebral venous pressure and decreased cerebral perfusion, cerebral white matter sparing-like changes, and widening of retinal vessel diameter. These changes are associated with numerous neurological signs and symptoms. Therefore, understanding the brain structural and functional changes in patients with cerebral venous outflow disturbance is essential to provide specific imaging evaluation indicators and new diagnosis and treatment methods for patients with cerebral venous return disorders.

Detailed Description
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Cerebral venous outflow disturbance can lead to cerebral hemodynamic disturbances, altered cerebrospinal fluid dynamics, cerebral venous blood stasis, increased cerebral venous pressure and decreased cerebral perfusion, cerebral white matter sparing-like changes, and widening of retinal vessel diameter. These changes are associated with numerous neurological signs and symptoms. A number of central nervous system disorders such as transient global amnesia, transient monocular blindness, primary labor headaches, and even Parkinson's have been reported to be closely associated with internal jugular vein stenosis. Other common clinical manifestations include sleep disturbances, tinnitus, tinnitus, headache, visual impairment, optic papilledema, hearing loss, cognitive decline and neck discomfort and even autonomic dysfunction. The main objective of this study is to investigate the structural and functional network changes in patients with cerebral venous outflow disturbance using different brain imaging techniques, to clarify the correlation between symptoms of cerebral venous outflow disturbance and brain structure and function; to identify areas with corresponding structural and functional changes in patients with cerebral venous outflow disturbance and or comorbid symptoms, and to provide specific imaging assessment indicators and new diagnostic and treatment tools for patients with cerebral venous outflow disturbance and comorbid symptoms.

Official Title
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Study on Brain Structure and Function Imaging in Patients With Cerebral Venous Outflow Disturbance

Conditions
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Image, Abnormal Cerebral Venous Sinus Morphology, Internal Jugular Vein Stenosis

Intervention / Treatment
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* Radiation: high-resolution 3D-T1
* Radiation: diffusion tensor imaging (DTI)
* Radiation: resting-state functional magnetic resonance imaging (rs-fMRI)
* Radiation: arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI)
* Radiation: susceptibility-weighted images (SWIs)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cerebral venous outflow disturbance( moderate to severe stenosis in cerebral venous sinus or intracranial jugular veins ) is confirmed by two of magnetic resonance venography (MRV), computed tomography venography (CTV) or digital subtraction angiography (DSA) Accompanying symptoms such as tinnitus cerebri, cognitive decline, anxiety depression, sleep disorders, etc. for more than 6 months Exclusion Criteria: ear primary disease medicine related intracranial hypertension; Systemic disease of abnormal metabolism or inflammation; moderate to severe stenosis in intracranial, carotid or vertebral arteries; intracranial lesions.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| CVOD-WS<br>Cerebral Venous Outflow Disturbance with symptoms such as tinnitus cerebri，somnipathy ，anxiety ，depression and cognitive decline | Radiation: high-resolution 3D-T1<br>* Subjects undergo a high-resolution 3D-T1 imaging to obtain structural images<br>Radiation: diffusion tensor imaging (DTI)<br>* Subjects undergo a DTI imaging to obtain images of white matter lesions<br>Radiation: resting-state functional magnetic resonance imaging (rs-fMRI)<br>* Subjects undergo rs-fMRI to investigate the differences in intra-regional brain activity and inter-regional functional connectivity<br>Radiation: arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI)<br>* Subjects undergo arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) to clarify the difference of cerebral blood flow (CBF) perfusion in certain regions<br>Radiation: susceptibility-weighted images (SWIs)<br>* Subjects undergo susceptibility-weighted images (SWIs) to segment the vein network<br>|
| CVOD-WOS<br>Cerebral Venous Outflow Disturbance without symptoms such as tinnitus cerebri，somnipathy ，anxiety ，depression and cognitive decline | Radiation: high-resolution 3D-T1<br>* Subjects undergo a high-resolution 3D-T1 imaging to obtain structural images<br>Radiation: diffusion tensor imaging (DTI)<br>* Subjects undergo a DTI imaging to obtain images of white matter lesions<br>Radiation: resting-state functional magnetic resonance imaging (rs-fMRI)<br>* Subjects undergo rs-fMRI to investigate the differences in intra-regional brain activity and inter-regional functional connectivity<br>Radiation: arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI)<br>* Subjects undergo arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) to clarify the difference of cerebral blood flow (CBF) perfusion in certain regions<br>Radiation: susceptibility-weighted images (SWIs)<br>* Subjects undergo susceptibility-weighted images (SWIs) to segment the vein network<br>|
| HC<br>Healthy control | Radiation: high-resolution 3D-T1<br>* Subjects undergo a high-resolution 3D-T1 imaging to obtain structural images<br>Radiation: diffusion tensor imaging (DTI)<br>* Subjects undergo a DTI imaging to obtain images of white matter lesions<br>Radiation: resting-state functional magnetic resonance imaging (rs-fMRI)<br>* Subjects undergo rs-fMRI to investigate the differences in intra-regional brain activity and inter-regional functional connectivity<br>Radiation: arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI)<br>* Subjects undergo arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) to clarify the difference of cerebral blood flow (CBF) perfusion in certain regions<br>Radiation: susceptibility-weighted images (SWIs)<br>* Subjects undergo susceptibility-weighted images (SWIs) to segment the vein network<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| voxel-based morphometry | Voxel-based morphometry (VBM) is used to obtain the relative gray matter volume (GMV) and WM volume (WMV) | at admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The amplitude of low-frequency fluctuations (ALFF) | The amplitude of low-frequency fluctuations (ALFF) is used to investigate the differences in intra-regional brain activity and inter-regional functional connectivity | at admission |