Relationship Between Oxytocin Level, Trust, and Attachment in Individuals With Borderline Personality Disorder

Study Overview
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Brief Summary
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We aim to assess the baseline oxytocin levels in individuals with borderline personality disorder and correlate those levels with social behavior, and compare the results with controls. Primary Hypothesis (H1): There is a significant difference in trust-related behavior as measured by oxytocin (OXT) levels between borderline personality disorder (BPD) patients and healthy controls. Secondary Hypotheses: H2: The trust-related behavior in BPD patients is significantly influenced by their level of emotional sensitivity. Specifically, higher emotional sensitivity in BPD patients is associated with lower trust-related behavior and vice-versa. H3: There is a significant correlation between trust-related behavior and childhood trauma in BPD patients. BPD patients with higher levels of reported childhood trauma will exhibit lower trust-related behavior compared to those with lower levels of trauma. H4: Trust-related behavior in BPD patients varies depending on their attachment styles. Specifically, BPD patients with insecure attachment styles will exhibit lower trust-related behavior compared to those with secure attachment styles. H5: There is a significant correlation between trust-related behavior and BPD severity. Patients with more severe BPD symptoms will exhibit lower trust-related behavior compared to those with less severe symptoms. H6: The levels of OXT in BPD patients will significantly correlate with their reported levels of emotional sensitivity, childhood trauma, attachment styles, and BPD severity. These hypotheses aim to address the complexities surrounding the modulation of trust-related behavior by oxytocin in BPD patients, taking into account various factors like emotional sensitivity, childhood adversity, attachment styles, and BPD severity. By testing these hypotheses, the study aims to provide a comprehensive understanding of the interplay between these factors in influencing trust-related behavior in BPD patients.

Official Title
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Relationship Between Oxytocin Level, Trust, and Attachment in Individuals With Borderline Personality Disorder

Conditions
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Borderline Personality Disorder

Intervention / Treatment
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* Other: baseline serum oxytocin levels
* Other: Emotional Sensitivity test
* Other: Neuro-economical game
* Other: Childhood Trauma Questionnaire
* Other: Relationships Questionnaire
* Other: demographic questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Individuals with borderline personality disorder will qualify as cases controls will be age, gender matched individuals without any psychiatric/mental health concerns Exclusion Criteria: for all: pregnancy, hormonal or neurological disorders, and any kind of regular medication additional exclusion criteria for cases: a lifetime diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder, or significant neurological disease, current alcohol/ drug dependence for controls: MacLEan screening instrument for BPD will be used at the time of screening to exclude BPD diagnosis in controls

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cases<br>Participants with borderline personality disorder who meet the inclusion criteria | Other: baseline serum oxytocin levels<br>* Both cases and controls will be assessed for their baseline serum oxytocin levels<br>Other: Emotional Sensitivity test<br>* To assess the level of emotional sensitivity in the participant<br>Other: Neuro-economical game<br>* A game played to assess the trust-index of participants<br>Other: Childhood Trauma Questionnaire<br>* to assess childhood trauma score<br>Other: Relationships Questionnaire<br>* to assess attachment type<br>Other: demographic questionnaire<br>* To obtain basic data on demographics<br>|
| Controls<br>Participants without borderline personality disorder, who meet the inclusion criteria | Other: baseline serum oxytocin levels<br>* Both cases and controls will be assessed for their baseline serum oxytocin levels<br>Other: Emotional Sensitivity test<br>* To assess the level of emotional sensitivity in the participant<br>Other: Neuro-economical game<br>* A game played to assess the trust-index of participants<br>Other: Childhood Trauma Questionnaire<br>* to assess childhood trauma score<br>Other: Relationships Questionnaire<br>* to assess attachment type<br>Other: demographic questionnaire<br>* To obtain basic data on demographics<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation of Oxytocin levels and trust index |  | Day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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oxytocin, borderline personality disorder, trust-related behavior, attachment styles, childhood trauma, emotional sensitivity