Assessing Lung Dynamics and Respiratory Functions in Minimal Flow Anesthesia: A Prospective Study

Study Overview
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Brief Summary
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The patients were randomized into two groups medium flow anesthesia (MeFA) and minimal flow anesthesia (MiFA). While MeFA received medium flow anesthesia with 2 lt/min, MiFA received minimal flow anesthesia with 0.5 lt/min fresh gas flow. In both groups dynamic compliance values, peak inspiratory pressure (PIP) values, total inhalation anesthetic drug consumption, total remifentanil drug consumption, duration of anesthesia, and duration of surgery were recorded. The FVC, FEV1, and FEV1/FVC values of the patients in both groups were evaluated and noted 24 hours before the operation, after the operation 2nd, 8th, and 24th hours.

Official Title
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EVALUATION OF LUNG DYNAMICS AND RESPIRATORY FUNCTIONS IN PATIENTS APPLIED WITH MINIMAL FLOW ANESTHESIA: A PROSPECTIVE, RANDOMIZED STUDY

Conditions
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Medium Flow Anesthesia, Minimal Flow Anesthesia, Pulmonary Function Test, Compliance, Patient, Peak Inspiratuar Pressure

Intervention / Treatment
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* Other: Medium flow anesthesia
* Other: Minimal flow anesthesia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA I-II 18-65 years of age, who will undergo elective laparoscopic cholecystectomy surgery Exclusion Criteria: ASA III-IV Smokers Body mass index (BMI) > 40 kg / m2, Patients with cardiovascular system disease Chronic respiratory diseases, Patients whose pulmonary function tests cannot be applied and who have problems with pulmonary function tests during the examination of the chest disease consultant

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Medium flow anesthesia<br>After reaching the MAC 1 value with 4lt/min 50% O2 - 50% air and 8% desflurane medium flow anesthesia was started with 2 lt/min 50% O2 - 50% air with MAC 1 concentration desflurane. | Other: Medium flow anesthesia<br>* Group MeFA; after reaching the MAC 1 value with 4lt/min 50% O2 - 50% air and 8% desflurane with remifentanil infusion, medium flow anesthesia was started with 2 lt/min 50% O2 - 50% air with MAC 1 concentration desflurane. The vaporizer was closed at the end of the last suture, and the flow was increased to 80% oxygen at 6 lt/min.<br>|
| Experimental: Minimal flow anesthesia<br>After reaching the MAC 1 value with 4 lt/min 50% O2 - 50% air and 8% desflurane minimal flow anesthesia was started with 0.50 lt/min 50% O2 - 50% air with MAC 1 concentration of desflurane. | Other: Minimal flow anesthesia<br>* Group MiFA; after reaching the MAC 1 value with 4 lt/min 50% O2 - 50% air and 8% desflurane with remifentanil infusion, minimal flow anesthesia was started with 0.50 lt/min 50% O2 - 50% air with MAC 1 concentration of desflurane. The vaporizer was closed at the end of the last suture, and the flow was increased to 80% oxygen at 6 lt/min.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dynamic Compliance assessment | Dynamic Compliance will be assessed 5th minutes after endotracheal intubation | 5th minutes after endotracheal intubation | 
| Dynamic Compliance assessment | Dynamic Compliance will be assessed 5th minutes after the surgical incision | 5th minutes after surgical incision | 
| Dynamic Compliance assessment | Dynamic Compliance will be assessed 10th minutes after the surgical incision | 10th minutes after surgical incision | 
| Dynamic Compliance assessment | Dynamic Compliance will be assessed 30th minutes after the surgical incision | 30th minutes after surgical incision | 
| Dynamic Compliance assessment | Dynamic Compliance will be assessed 60th minutes after the surgical incision | 60th minutes after surgical incision | 
| Dynamic Compliance assessment | Dynamic Compliance will be assessed immediately after the end of the surgical suturing | immediately after the end of the surgical suturing | 
| Peak inspiratory pressure assessment | Peak inspiratory pressure will be assessed 5th minutes after endotracheal intubation | 5th minutes after endotracheal intubation | 
| Peak inspiratory pressure assessment | Peak inspiratory pressure will be assessed 5th minutes after the surgical incision | 5th minutes after the surgical incision | 
| Peak inspiratory pressure assessment | Peak inspiratory pressure will be assessed 10th minutes after the surgical incision | 10th minutes after the surgical incision | 
| Peak inspiratory pressure assessment | Peak inspiratory pressure will be assessed 30th minutes after the surgical incision | 30th minutes after the surgical incision | 
| Peak inspiratory pressure assessment | Peak inspiratory pressure will be assessed 60th minutes after the surgical incision | 60th minutes after the surgical incision | 
| Peak inspiratory pressure assessment | Peak inspiratory pressure will be assessed immediately after the end of the surgical suturing | immediately after the end of the surgical suturing | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| FEV1 measures assessment | FEV1 measures assessment will be assessed 24 hours before the operation | 24 hours before the operation | 
| FEV1 measures assessment | FEV1 measures assessment will be assessed 2nd hours after the operation | 2nd hour after the operation | 
| FEV1 measures assessmentt | FEV1 measures assessment will be assessed 8th hours after the operation | 8th hour after the operation | 
| FEV1 measures assessment | FEV1 measures assessment will be assessed 24th hours after the operation | 24th hour after the operation | 
| FVC measures assessment | FVC measures assessment will be assessed 24 hours before the operation | 24 hours before the operation | 
| FVC measures assessment | FVC measures assessment will be assessed 2nd hour after the operation | 2nd hour after the operation | 
| FVC measures assessment | FVC measures assessment will be assessed 8th hour after the operation | 8th hour after the operation | 
| FVC measures assessment | FVC measures assessment will be assessed 24th hours after the operation | 24th hour after the operation | 
| FEV1/FVC measures assessment | FEV1/FVC measures assessment will be assessed 24 hours before the operation | 24 hours before the operation | 
| FEV1/FVC measures assessment | FEV1/FVC measures assessment will be assessed 2nd hour after the operation | 2nd hour after the operation | 
| FEV1/FVC measures assessment | FEV1/FVC measures assessment will be assessed 8th hour after the operation | 8th hour after the operation | 
| FEV1/FVC measures assessment | FEV1/FVC measures assessment will be assessed 24th hour after the operation | 24th hour after the operation |