Refining the Interpretation of the Tinel's Sign for Carpal Tunnel Syndrome

Study Overview
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Brief Summary
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This is an observational study to investigate the electromyographic (EMG) activity and nerve conduction velocity (NCV) of healthy individuals during the Tinel's Sign performed at different wrist positions. The study aims to identify the wrist position that best isolates median nerve activity during the Tinel's Sign.

Detailed Description
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The study will be conducted in a controlled laboratory setting, equipped with an electromyography (EMG) machine and a nerve conduction velocity (NCV) measurement device. We will recruit 30 healthy adults, aged 18-45 years, with no history of hand or wrist pain, neurological or muscular disorders. Participants will be excluded if they have any contraindications to EMG or NCV measurement. The independent variable will be the wrist position during the Tinel's Sign, and the dependent variables will be the EMG activity of the thenar and hypothenar muscles and the NCV of the median and ulnar nerves. EMG activity will be measured using surface electrodes placed on the thenar and hypothenar muscles. NCV will be measured using a standard NCV measurement device. To minimize bias, the same trained examiner will perform all tests and measurements, and the examiner will be blinded to the EMG and NCV data during the tests. Differences in EMG activity and NCV across different wrist positions will be analyzed using repeated measures ANOVA. Post-hoc pairwise comparisons will be performed using Bonferroni correction. The study protocol will be submitted to the local ethics committee for approval, and all participants will provide informed consent.

Official Title
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Refining the Interpretation of the Tinel's Sign for Carpal Tunnel Syndrome: An Electromyographic and Nerve Conduction Velocity Study

Conditions
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Carpal Tunnel Syndrome

Intervention / Treatment
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* Diagnostic Test: Tinel's Sign performed at different wrist positions


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy individuals aged 18-45 years No history of hand or wrist pain, neurological or muscular disorders Exclusion Criteria: Any contraindications to EMG or NCV measurement

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy individuals<br>Participants will undergo the Tinel's Sign at different wrist positions while EMG activity and NCV are recorded. | Diagnostic Test: Tinel's Sign performed at different wrist positions<br>* Participants will undergo the Tinel's Sign at different wrist positions while EMG activity and NCV are recorded to investigate the effect of wrist position on median nerve activity.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EMG activity of the thenar muscles during the Tinel's Sign performed at different wrist positions. | The amplitude of EMG activity of the thenar muscles will be measured during the Tinel's Sign performed at different wrist positions. The amplitude will be quantified in microvolts (µV). | Baseline | 
| EMG activity of the hypothenar muscles during the Tinel's Sign performed at different wrist positions. | The amplitude of EMG activity of the hypothenar muscles will be measured during the Tinel's Sign performed at different wrist positions. The amplitude will be quantified in microvolts (µV). | Baseline | 
| Nerve conduction velocity of the median nerve during the Tinel's Sign performed at different wrist positions. | The NCV of the median nerve will be measured during the Tinel's Sign performed at different wrist positions. The NCV will be quantified in meters per second (m/s). | Baseline | 
| Nerve conduction velocity of the ulnar nerve during the Tinel's Sign performed at different wrist positions. | The NCV of the ulnar nerve will be measured during the Tinel's Sign performed at different wrist positions. The NCV will be quantified in meters per second (m/s). | Baseline |