Delayed Dinner, Exercise and Glucose Metabolism

Study Overview
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Brief Summary
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This study aims to investigate whether exercise can alleviate the impact of delayed dinner on metabolic health next morning in sedentary healthy adults

Official Title
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Impact of Exercise on Metabolic Health Following Delayed Dinner Consumption in Healthy Adults

Conditions
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Normal Dinner, Delayed Dinner, Exercise Plus Delayed Dinner

Intervention / Treatment
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* Behavioral: Normal dinner
* Behavioral: Delayed dinner consumption
* Behavioral: Exercise with delayed dinner consumption


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Physical inactive males Weight stable for more than 3 months (no change in weight +/- 3%) Non-smoker Able to walk comfortably on a treadmill Dinner consumers with normal sleep pattern (cycles) Exclusion Criteria: Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia Taking medications that may influence lipid or carbohydrate metabolism or immune system function Unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Normal dinner consumption<br>Participants will have their dinner between 1800-1830pm | Behavioral: Normal dinner<br>* Participants will consume breakfast at 0830-0855 am, lunch at 1230-1255 pm, followed by dinner at 1800-1825 pm. Snacks will be consumed at 2130-2140 pm.<br>|
| Experimental: Delayed dinner consumption<br>Participants will have their dinner between 2200-2230pm | Behavioral: Delayed dinner consumption<br>* Participants will consume breakfast at 08:30-08:55 am, lunch at 12:30-12:55 pm, followed by snacks at 18:00-18:10 pm. Dinner will be consumed at 21:30-21:55 pm.<br>|
| Experimental: Exercise with delayed dinner consumption<br>Participants will exercise on a treadmill for 45 min followed by delayed dinner between 2200-2230pm | Behavioral: Exercise with delayed dinner consumption<br>* Participants will consume breakfast at 08:30-08:55 am, lunch at 12:30-12:55 pm, followed by snacks at 18:00-18:10 pm. Participants will exercise for 45 min at moderate-intensity 45 min prior to the delayed dinner at 21:30-21:55 pm.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Metabolic health (Oral glucose tolerance test, OGTT) | Fasting and postprandial blood glucose responses on next morning between trials | 120 minutes | 
| Metabolic health (Oral glucose tolerance test, OGTT) | Fasting and postprandial blood insulin responses on next morning between trials | 120 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Inflammation | Fasting inflammatory biomarkers (IL-6, TNF-a, CRP) on next morning between trials | Baseline | 
| Visual analogue scale (VSA) | Changes in VAS from 0-100 mm (e.g., appetite & mood, etc.) on next morning between trials | 120 minutes | 
| Substate oxidation | Lipid and carbohydrate oxidation during OGTT between trials | 120 minutes | 
| Blood pressure | Changes in blood pressure (systolic and diastolic blood pressure) on next morning between trials | 120 minutes | 
| Appetite (lunch intake) | Ab libitum energy intake on next morning by the end of trial | 30 minutes | 
| HRV | Heart rate variability on next morning between trial | Baseline | 
| Gut hormones | Changes in blood gut hormones responses on next morning (e.g., GLP-1, PYY and GIP) between trials | 120 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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late dinner, postprandial Glycaemia