The Effect of Huel Powder on Appetite

Study Overview
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Brief Summary
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This project will assess the effect of Huel powdered food on the satiety of 40 generally healthy volunteers compared to a standard breakfast of cornflakes and milk. To achieve this, we will recruit 40 (non-smoking) generally healthy volunteers to attend the study centre on two separate occasions. On each occasion they will arrive at the study centre fasted and will be given their breakfast of either Huel or Cornflakes and milk, matched for calorie content. The aim is to identify the size and duration of any effect on satiety of the two meals.

Detailed Description
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This project will assess the effect of Huel Food replacement on the satiety of 40 generally healthy volunteers compared to a standard breakfast of cornflakes and milk. To achieve this, we will recruit 40 (non-smoking) generally healthy volunteers to attend the study centre on two separate occasions. On each occasion they will arrive at the study centre fasted and will be given their breakfast of either Huel or Cornflakes and milk, matched for calorie content. We will ask volunteers to come to the research facility in Newcastle University, before they have had any breakfast, on two separate occasions. The volunteers must not eat or drink anything (except water) after 8 pm the evening before they come in. This includes not drinking any alcohol, tea, or coffee. BMI, weight, and body composition (measured via electrical impedance) will also be taken at the initial visit to ensure they meet the inclusion criteria All volunteers will be asked to complete screening questionnaires focusing on morning eating and exercise routine and the 'three factor eating' questionnaire before or during their screening visit. A subset of volunteers (eight in total) will be recruited to collected blood samples throughout the two study visits. These volunteers will go through the same screening process but will also have their veins assessed for cannulation suitability. During the two study visits, both sets of volunteers will be asked to complete appetite questionnaires every 15 minutes for the first hour and every 30 minutes for the remaining 3 hours. Volunteers who have consented to provide blood samples will be asked to give samples just before they complete the appetite questionnaires. The blood samples will be assessed for Ghrelin, CCK, PYY, Glucose, and Insulin. All researchers are trained in GCP, phlebotomy and cannulation.

Official Title
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The Effect of Huel Powder on Appetite

Conditions
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Hunger

Intervention / Treatment
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* Other: Huel Powder


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Generally Healthy Non-pregnant/lactating No known food allergies BMI between 20-30 Exclusion Criteria: Diagnosed eating disorder receiving regular medication (except contraceptives or statins) long-term illness such as high blood pressure, heart disease taking medication that can affect kidney function

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Randomised, open label crossover study
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Huel Powder<br>This arm of the study will receive Huel as their first study meal with cornflakes and milk as their second | Other: Huel Powder<br>* Huel Powder v3.0 white, vanilla flavour<br>|
| Active Comparator: Cornflakes and Milk<br>This arm of the study will receive cornflakes and milk as their first study meal with Huel as their second | Other: Huel Powder<br>* Huel Powder v3.0 white, vanilla flavour<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hunger Visual Analogue Score | How hungry do you feel? | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | 
| Satisfied Visual Analogue Score | How satisfied do you feel? | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | 
| Fullness Visual Analogue Score | How full do you feel? | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | 
| How much can you eat Visual Analogue Score | How much do you think you can eat? | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sweet Visual Analogue Score | Would you like to eat something sweet? | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | 
| Salty Visual Analogue Score | Would you like to eat something salty? | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | 
| Savoury Visual Analogue Score | Would you like to eat something savoury? | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | 
| Fatty Visual Analogue Score | Would you like to eat something fatty? | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | 
| PYY | Concentration of Peptide YY in plasma (pg/ml) | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | 
| Ghrelin | Concentration of Ghrelin in plasma (pg/ml) | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | 
| CCK | Concentration of Cholecystokinin in plasma (pg/ml) | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | 
| Glucose | Concentration of glucose in plasma (mmol/l) | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | 
| Insulin | Concentration of Insulin in plasma (pmol/l) | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Satiety, Appetite