Magnetoencephalography by Optical Pumping Magnetometer

Study Overview
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Brief Summary
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MagnetoEncephaloGraphy (MEG) is a method of recording brain activity with high temporal resolution and good spatial resolution, compared to current recording techniques such as ElectroEncephaloGraphy (EEG). The main limitation of MEG is its cost due to the sensors used, the Super Quantum Interference Devices (SQUID). These require a complex infrastructure from an instrumentation point of view to operate, requiring liquid helium, most often at a loss, at increasing cost. Optical Pumping Magnetometers (OPM) type sensors represent a promising alternative to SQUIDs sensors, especially since they do not require helium cooling. The purpose of this project is to Identify biomarkers in Magnetoencephalography of normal brain development in healthy adults, premature and term newborns from a priori obtained by the classical technique of High Resolution EEG performed.

Official Title
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Magnetoencephalography by Optical Pumping Magnetometer

Conditions
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Magnetoencephalography, Optical Pump Magnetometer, Neonate, Premature

Intervention / Treatment
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* Other: Magnetoencephalography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For healthy adult volunteers Age between 18 and 65 No pathology, no treatment No toxicant intake For term newborns Child between 38 and 42 weeks gestational age on the day of registration No pathology, no treatment For children born prematurely Child between 28 and 36 weeks gestational age on the day of registration No pathology, no treatment apart from routine care related to prematurity For pregnant women Pregnant with between 28 to 40 weeks gestational age on the day of registration No pathology, no treatment Exclusion Criteria: Subject and Patients not compatible MEG. Wearers of prosthesis or pacemaker likely to generate artefacts interfering with the measurement. There is no danger to the subject, but the measurement itself may be impossible. Patients who cannot stand to stand still for a few minutes. Newborn on ventilatory assistance or infusion Newborn baby not meeting the age criteria

Ages Eligible for Study
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Minimum Age: 1 Day

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Adults<br> | Other: Magnetoencephalography<br>* 40 minutes of Magnetoencephalography with Optical Pump Magnetometer<br>|
| Experimental: full term neonates<br> | Other: Magnetoencephalography<br>* 40 minutes of Magnetoencephalography with Optical Pump Magnetometer<br>|
| Experimental: premature neonates<br> | Other: Magnetoencephalography<br>* 40 minutes of Magnetoencephalography with Optical Pump Magnetometer<br>|
| Experimental: pregnant women<br> | Other: Magnetoencephalography<br>* 40 minutes of Magnetoencephalography with Optical Pump Magnetometer<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Signal to noise ratio of the MEG OPM | Signal to noise ratio of the MEG OPM is in dB | 1 day | 
| Signal to noise ratio of HR EEG | Signal to noise ratio of HR EEG is in dB | 1 day | 
| Number of dB between Signal to noise ratio of the MEG OPM and Signal to noise ratio of HR EEG |  | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Magnetoencephalography, optical pump magnetometer, neonate, Premature