Influence of Enteral Microbiome on Mortality of Patients With Cardiogenic Shock

Study Overview
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Brief Summary
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Cardiogenic shock is associated with a high mortality. The microbiome is a double-edged sword which can convey protective and detrimental cardiovascular effects. The significance of the enteral micobiome on cardiovascular mortality of patients with cardiogenic shock is still not known. This study aims to provide a deeper understanding of the role of the enteral microbiome and microbiome dependent metabolites in mortality and disease progression of patients with cardiogenic shock.

Official Title
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Influence of Enteral Microbiome Composition and Microbiome Dependent Metabolites on Mortality of Patients With Cardiogenic Shock

Conditions
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Cardiogenic Shock, Microbial Colonization, Out-Of-Hospital Cardiac Arrest, Acute Heart Failure, Acute Myocardial Infarction

Intervention / Treatment
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* Other: Observational study


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: >18y signs of cardiogenic shock regardless of etiology lactate >3mmol/L and signs of organ dysfunction (urine output <30 ml/h, cold extremities, altered mental status) and systolic blood pressure <90 mmHg for >30 minutes or need for vasopressor therapy Exclusion Criteria: pregnancy/lactation period antibiotic treatment within >24h chronic inflammatory bowel disease short bowel syndrome artificial bowel outlet persistent diarrhea or vomiting in the past 3 months simultaneous participation in another interfering nutrition study active chemo or radiation therapy

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cardiogenic shock<br> | Other: Observational study<br>* No intervention: observational study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between enteral microbiome composition and mortality | Stool samples are collected and clinical evaluation will be performed at below mentioned time points | Sampling will be performed within 24 hours of onset of cardiogenic shock and clinical evaluation will be performed after 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between TMAO serum level and mortality | Blood samples are collected at below mentioned time points | Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3 | 
| Correlation between SCFA serum level and mortality | Blood samples are collected at below mentioned time points | Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3 | 
| Correlation between inflammatory profile (CRP, PCT, Interleukin panel) and mortality | Blood samples are collected at below mentioned time points | Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3 |