Assessment of Intestinal Inflammation by Infrared Thermography in Pediatric Crohn Disease

Study Overview
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Brief Summary
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The assessment of digestive inflammation and disease activity in paediatrics Crohn's disease (CD) is currently based on anamnestic, clinical and paraclinical elements such as the paediatric CD activity index (wPCDAI) , faecal calprotectin measuring or digestive endoscopy. Infrared thermal imaging is based on capturing electromagnetic waves, on a specific Wavelength, emitted by the human body surface and representing local thermic-metabolic activity. It concern metabolic activity in digestive inflammations. Infrared imaging is a non-invasive, contactless, stressless technique that assess the variations in skin surface temperature of the patient's entire abdomen or more targeted areas in a single photography. This technique would be useful for determination of Crohn's disease activity, inflammation's degree and partial mapping of inflammatory lesions. In a specific room with a patient lying, the investigators will determine the abdominal infrared radiation with a FLIR® thermal camera. This will be correlated with the measurement of the faecal calprotectin concentration and the composite CD activity index wPCDAI. All measurements will be performed during the standard follow-up of Crohn disease. No additional follow will be necessary.

Official Title
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Assessment of Intestinal Inflammation by Infrared Thermography in Pediatric Crohn Disease

Conditions
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Crohn Disease, Infrared Thermography, Child

Intervention / Treatment
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* Other: abdominal infrared radiation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients diagnosed with CD according to the Porto criteria [6] Aged from 4 years to 17 years-old Follow-up at the Amiens Picardie University Hospital (CHU Amiens Picardie) Child's affirmative agreement and assent and permission of their parents to participate in research Exclusion Criteria: Recent abdominal surgery Other Inflammatory bowel disease

Ages Eligible for Study
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Minimum Age: 4 Years
Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: abdominal infrared radiation|In a specific room (controlled temperature and humidity) with a patient lying on his back, we will determine the abdominal infrared radiation with a FLIR® thermal camera (without contact) and quantify the thermal signal by spectral analysis (in degrees Celsius).|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlation between the quantification of abdominal infrared radiation and faecal calprotectin concentration | correlation between the quantification of abdominal infrared radiation determined by the FLIR® thermal camera and quantified by the spectral analysis of the thermal signal (in degrees Celsius) and the determination of faecal calprotectin concentration (µg/g of faeces). This concentration will be determined by ELISA method at Biochemistry in Amiens Picardie Faculty hospital. | one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Crohn Disease, Infrared thermography, Faecal Calprotectin, PCDAI, Child