Correlation Between Preoperative Knee Extension Lag and Functional Outcome After Total Knee Arthroplasty

Study Overview
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Brief Summary
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To explore the relationship between different knee extension hysteresis angles and functional outcome of knee joint after total knee replacement

Detailed Description
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Collect perioperative baseline data Subjects were recruited and perioperative baseline data were collected: ① Demographic information, including age, sex, height, weight, affected knee, etc. ②Body structure and function: joint motion, knee extension hysteresis angle, pain NRS, WOMAC assessment, and ultrasonic knee extension mechanism were measured before and 3 days after surgery. Postoperative follow-up The patients were followed up for 3 months, and 6 weeks /3 months after surgery was selected as the follow-up node. The follow-up included postoperative range of motion, knee extension hysteresis Angle, pain NRS, WOMAC assessment, ultrasonic measuring knee extension mechanism, TUG Test (Timed Up-to-go Test), isometric muscle force test, balance postural graph, gait analysis, etc. Data analysis Multi-factor regression analysis was performed to determine the main outcome indicators of WOMAC evaluation at 3-month follow-up, including range of motion, Angle of knee extension hysteria, pain NRS, ultrasonic knee extension device, TUG Test (Timed Up-to-go Test), isoktatic muscle force test, balance postural graph and secondary outcome indicators of gait analysis. The perioperative knee extension hysteresis Angle was used as the independent variable to construct the postoperative regression model of knee function. According to the Angle of knee extension hysteresis in perioperative period, patients were divided into 4 groups: ≤5°, 5-10°11-15°, ≥15°, The results of range of motion, knee extension hysteresis Angle, pain NRS, WOMAC score, ultrasonic knee extension device, TUG Test (Timed Up to go Test), iso-tachykinesis test, balance postural mapping and gait analysis were compared among all groups 3 months after surgery. Study outcome Follow-up was completed; The patient underwent revision surgery for knee osteoarthritis. The patient dropped out of the trial for personal reasons; Other unforeseen circumstances prevented the patient from continuing the trial.

Official Title
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Correlation Analysis of Knee Extension Lag Angle and Knee Function After Total Knee Arthroplasty

Conditions
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Extension Lag, Total Knee Arthroplasty

Intervention / Treatment
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* Procedure: total knee arthroplasty


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: (1) Patients who meet the diagnostic criteria of knee osteoarthritis (age >45 years old); (2) Patients admitted to the Department of Orthopedics of the Third Hospital of Beijing Medical University and preparing to receive TKA surgery; (3) The patient has good cognitive function and good compliance, and can cooperate with various examinations; (4) Voluntarily participate in the study and sign the informed consent; Exclusion Criteria: (1) Patients with lower extremity fracture and severe lumbar spinal stenosis that affect postoperative functional recovery; (2) Patients with severe cerebrovascular disease who cannot cooperate with postoperative rehabilitation exercise; (3) The time interval of double knee replacement was less than 3 months.

Ages Eligible for Study
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Minimum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| <5°<br> | Procedure: total knee arthroplasty<br>* To observe the postoperative functional outcome of patients with knee extension lag at different angles<br>|
| 5-10°<br> | Procedure: total knee arthroplasty<br>* To observe the postoperative functional outcome of patients with knee extension lag at different angles<br>|
| 10-15°<br> | Procedure: total knee arthroplasty<br>* To observe the postoperative functional outcome of patients with knee extension lag at different angles<br>|
| ≥15°<br> | Procedure: total knee arthroplasty<br>* To observe the postoperative functional outcome of patients with knee extension lag at different angles<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| WOMAC | Knee functional scale | three months after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Thickness of vastus medialis muscle | muscle thickness | three months after surgery | 
| range of motion | Reflect knee function | three months after surgery |