Assessment of Bronchial Obstruction in Adolescents With HIV

Study Overview
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Brief Summary
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In children, data from the literature find a higher prevalence of asthma in the population treated for HIV. Bronchial hyperreactivity, indicative of chronic inflammation and bronchial obstruction, is also present. Screening for early peripheral obstruction could therefore make it possible to initiate appropriate anti-inflammatory treatment, if necessary, and early preventive management.

Detailed Description
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In adults chronically infected with HIV, there is an increased prevalence impaired respiratory function, with a greater occurrence of COPD than in the uninfected population. In children, data from the literature find a prevalence of greater atopy in the HIV-infected pediatric population. Furthermore, a bronchial hyperreactivity or even peripheral bronchial obstruction, indicative of a local chronic inflammation has been found in young adolescents treated since the birth for HIV infection in utero. Screening for early peripheral obstruction in HIV-infected adolescents could therefore make it possible to initiate, if necessary, a anti-inflammatory treatment, and early management to prevent the occurrence of impaired respiratory function in adulthood For this this single-center prospective study chose to perform respiratory function explorations with forced oscillometry with the Endpoint main factor of the peripheral obstruction the R5HZ parameter expressed in % predicted. Patients from 11 to 25 years to whom it was proposed added to that to answer a questionnaire of respiratory quality of life

Official Title
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Assessment of Bronchial Obstruction in Adolescents With HIV

Conditions
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HIV

Intervention / Treatment
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* Diagnostic Test: pulmonary function tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children over 11 and Under 25-year-old infected with HIV and on antiretrovirals and followed up at Robert Debré hospital for this pathology Consent of the holders of parental authority and Patients informed and not objecting to participate in research Exclusion Criteria : • Age ≤ 11 years old Not treated for HIV Patients under guardianship / curatorship

Ages Eligible for Study
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Minimum Age: 11 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: pulmonary function tests<br> | Diagnostic Test: pulmonary function tests<br>* pulmonary function tests<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Resistance measured by forced oscillometry (5hZ) | Resistance measured by forced oscillometry (5hZ) | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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antiretrovirals