Ocular Changes With Alpha-2 Receptor Agonist.

Study Overview
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Brief Summary
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selective alpha-2 receptor agonists cause changes in intraocular pressure and pupillary size thus may affect patient quality of life.

Detailed Description
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In this research, we will analyze the effect of selective alpha-2 receptor agonists on the human eye and investigate ocular changes over 6 months after its topical use.

Official Title
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Ocular Changes After Selective Alpha-2 Receptor Agonist.

Conditions
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Glaucoma, Suspect, Aberration, Corneal Wavefront

Intervention / Treatment
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* Drug: Low dosage selective alpha-2 receptor agonists topical eyedrop
* Drug: High dosage selective alpha-2 receptor agonists topical eyedrop


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Glaucoma suspect cases. post-refractive surgery cases. Exclusion Criteria: Cases with prostatic hyperplasia or diabetics that may alter the measurements of pupillary diameter. Cases with previous history of any retinal intervention or other drugs that may alter intraocular pressure measurements.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Glaucoma suspect group<br>Cases diagnosed as glaucoma suspect | Drug: Low dosage selective alpha-2 receptor agonists topical eyedrop<br>* Using selective alpha-2 receptor agonists eyedrop in both groups with 0.2% concentration.<br>* Other names: Topical selective alpha-2 receptor agonists;Drug: High dosage selective alpha-2 receptor agonists topical eyedrop<br>* Using selective alpha-2 receptor agonists eyedrop in both groups with 0.02% concentration.<br>* Other names: Topical selective alpha-2 receptor agonists;|
| Active Comparator: Post-refractive surgery group<br>Cases had undergone refractive surgery | Drug: Low dosage selective alpha-2 receptor agonists topical eyedrop<br>* Using selective alpha-2 receptor agonists eyedrop in both groups with 0.2% concentration.<br>* Other names: Topical selective alpha-2 receptor agonists;Drug: High dosage selective alpha-2 receptor agonists topical eyedrop<br>* Using selective alpha-2 receptor agonists eyedrop in both groups with 0.02% concentration.<br>* Other names: Topical selective alpha-2 receptor agonists;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraocular pressure | Changes in intraocular pressure measured in mmHg by applanation tonometry | Baseline and 6 months after regular use of the topical eyedrops | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pupillary diameter | Changes in the pupillary diameter measured in mm by handheld pupillometer | Baseline and 6 months after regular use of the topical eyedrops | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Glaucoma suspect, Post-lasik