Intracranial Pressure and Optic Nerve Sheath Diameter With CLOSED Bundle

Study Overview
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Brief Summary
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The design of the present study will be a multicenter prospective observational protocol. Approximately 100 patients will be recruited over the 24-month period with Acute Brain Injury (trauma brain injury, intracerebral hemorrhage, subarachnoid hemorrhage, ischemic stroke), who in their acute phase of intensive care unit require placement of a catheter capable of monitoring intracranial pressure (intra parenchymal catheter or external ventricular shunt). In addition to all the intensive care provided by the most recent guidelines, patients will undergo measurement of optic nerve sheath diameter through ultrasonography. At least, three measurements will be performed within the first 3 hours after admission, within the first 24-48 hours, and at each invasive intracranial pressure value greater than 18 cmH2O. Those patients with intracranial pressure values greater than 35 mmHg. At the first intracranial pressure measurement, patients with eyeball disease or trauma will be excluded. Measurements will be performed following the CLOSED bundle. Analysis of the results will include correlation between the invasive pressure values and the mean value of optic nerve sheath diameter measurements in the two projections (sagittal and transverse). In addition, the correlation of the absolute value of invasive pressure detected with the ratio of the optic nerve sheath diameter measurement to the eyeball diameter measured always ultrasound will be sought.

Official Title
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Correlation Between Intracranial Pressure and Optic Nerve Sheath Diameter Measured With CLOSED Bundle in Patients With Acute Brain Injury: Multicenter Observational Study

Conditions
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Intra Cerebral Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Trauma, Brain, Hypertension Intracranial, Stroke, Ischemic

Intervention / Treatment
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* Diagnostic Test: ultrasound optic nerve sheath diameter assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: acute brain injury patients with an invasive intra-cranial pressure monitoring - Exclusion Criteria: patients affected by disease or trauma of eye ball patients or relatives that don't want to participate to the study -

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| acute brain injury<br>Intra Cerebral Hemorrhage Subarachnoid Hemorrhage, Aneurysmal Trauma, Brain Stroke, Ischemic | Diagnostic Test: ultrasound optic nerve sheath diameter assessment<br>* ultrasound optic nerve sheath diameter assessment<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlation between invasive ICP/ONSD | correlation between invasive intra-cranial pression assessment and ultasound ONSD assessment | 3, 24, 48 hours after admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlation between invasive intra-cranial pression assessment and ultasound ratio of ONSD assessment and eyeball transverse diameter | correlation between invasive ICP/(ONSD/ETD) | 3, 24, 48 hours after admission | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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optic nerve sheath diameter, ultrasonography, Hypertension Intracranial, neuro monitoring