The Robot-Assisted Laparoscopic Radical Prostatectomy Combined Anterior and Posterior Approach

Study Overview
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Brief Summary
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The goal of this observational study was to compare the perioperative outcomes, postoperative urinary control rates and positive surgical margin (PSM) rates of the robot-assisted laparoscopic radical prostatectomy combined anterior and posterior approach (AP-RARP) with the Retzius-sparing approach (RS-RARP) and anterior approach (anterior-RARP) in the treatment of prostate cancer. The main question it aims to answer was: • The early therapeutic efficacy of the robot-assisted laparoscopic radical prostatectomy combined anterior and posterior approach Participants has been underwent: AP-RARP RS-RARP anterior-RARP Researchers compared the three groups to see if AP-RARP combines the advantages of anterior and posterior RARP and is a feasible surgical option for the treatment of prostate cancer.

Official Title
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The Early Therapeutic Efficacy of The Robot-Assisted Laparoscopic Radical Prostatectomy Combined Anterior and Posterior Approach: A Single-Center Retrospective Cohort Study

Conditions
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Prostatectomy, Prostate Neoplasm

Intervention / Treatment
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* Procedure: the robot-assisted laparoscopic radical prostatectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: pathologically diagnosed with prostate cancer by prostate biopsy underwent robot-assisted laparoscopic surgery the surgery performed by Weidong Gan the extended pelvic lymphadenectomy (PLA) is performed on patients with high-risk prostate cancer (PSA≥20 ng/ml or Grade Group 4-5 or clinical stage ≥T2c) and those considered to have a possibility of lymph node metastasis based on imaging evaluation. Exclusion Criteria: Patients with a clinical and pathological TNM stage ≥T3b and N1 patients with distant metastasis urinary incontinence before surgery received neoadjuvant therapy before surgery
Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| AP-RARP<br>the robot-assisted laparoscopic radical prostatectomy combined anterior and posterior approach | Procedure: the robot-assisted laparoscopic radical prostatectomy<br>* We collect medical data of 233 patients with clinically localized prostate cancer who underwent AP-RARP, RS-RARP or anterior-RARP. Perioperative outcomes, including operation time, intraoperative blood loss, intraoperative and postoperative transfusion, postoperative infection, and anastomotic leakage, were compared among the three groups. The postoperative continence rates and PSM rates were also compared.<br>|
| RS-RARP<br>the robot-assisted laparoscopic radical prostatectomy with the Retzius-sparing approach | Procedure: the robot-assisted laparoscopic radical prostatectomy<br>* We collect medical data of 233 patients with clinically localized prostate cancer who underwent AP-RARP, RS-RARP or anterior-RARP. Perioperative outcomes, including operation time, intraoperative blood loss, intraoperative and postoperative transfusion, postoperative infection, and anastomotic leakage, were compared among the three groups. The postoperative continence rates and PSM rates were also compared.<br>|
| anterior-RARP<br>he robot-assisted laparoscopic radical prostatectomy with anterior approach | Procedure: the robot-assisted laparoscopic radical prostatectomy<br>* We collect medical data of 233 patients with clinically localized prostate cancer who underwent AP-RARP, RS-RARP or anterior-RARP. Perioperative outcomes, including operation time, intraoperative blood loss, intraoperative and postoperative transfusion, postoperative infection, and anastomotic leakage, were compared among the three groups. The postoperative continence rates and PSM rates were also compared.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| urinary continence | was defined as using 0-1 pad a day | 0-6 month after surgery | 
| positive surgical margin | observed whether the tissue cutting in surgery has tumor cell in surgical margin by pathologist | 2 weeks after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| operating time | The start time of the operation refers to the time of incision of the skin at the surgical site. The end time of surgery refers to the time when the skin is sutured. | the day of the surgery | 
| intraoperative blood loss | Intraoperative bleeding was defined as the sum of blood content in blood gauze, blood content in negative pressure suction bottle and blood clot volume. | the day of the surgery |