Doppler at the Diagnosis in Predicting Perinatal Outcomes in Early and Late-onset Fetal Growth Restriction

Study Overview
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Brief Summary
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When a FGR is diagnose, the challenge in his monitoring is to assess the benefit-risk balance between continuing the pregnancy in order to limit complications related to prematurity and birth in order to minimize any risk of fetal death in utero. By able to know the characteristics of fetal deteriorations and its relationship with fetal and neonatal outcomes could be a thankful help in this decision. The placental insufficiency is by far the most common cause of FGR (32)(miller 2008). This effect can be documented thanks to ultrasound examinations to study fetal growth and Doppler of umbilical arteries for the placenta, the middle cerebral artery for the brain perfusion and the Ductus Venosus for the cardiac effects of placental dysfunction. The apparition of Doppler abnormalities suggests a deterioration of the disease and leads to several changes in clinical FGR management. Nevertheless, at this time, very few studies allow us to predict the time util the degradation and their impact on perinatal outcomes. The primary aim of this study was to evaluate the performance of the Doppler at the time of diagnosis in predicting the outcome of pregnancies. The secondary aim was to evaluate the performance of Doppler performed at any time during pregnancy and studied independently in predicting outcome of pregnancies

Official Title
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Doppler at the Diagnosis in Predicting Perinatal Outcomes in Early and Late-onset Fetal Growth Restriction

Conditions
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Fetal Growth Retardation

Intervention / Treatment
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* Other: Ultrasound


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Fetal growth restriction of antenatal diagnosis Exclusion Criteria: Twin pregnancies, non-isolated IUGR, post-natal diagnosis of FGR and incomplete records

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Early fetal growth restriction<br>Fetal growth restriction diagnosed before 32 SA | Other: Ultrasound<br>* Doppler mesure<br>|
| Late fetal growth restriction<br>Fetal growth restriction diagnosed after 32 SA | Other: Ultrasound<br>* Doppler mesure<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| evaluate the performance of the Doppler at the time of diagnosis in predicting the outcome of pregnancies |  | during pregnancy (6 month per patient maximum) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| evaluate the performance of Doppler performed at any time during pregnancy and studied independently in predicting outcome of pregnancies |  | during pregnancy (6 month per patient maximum) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Fetal Growth Retardation, Doppler, perinatale outcome