Deprescribing and Health-related Effects

Study Overview
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Brief Summary
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In a primary care settled quality improvement project aiming to deprescribe medication through a medication review intervention, we investigated how the implemented medication changes affected health-related outcomes in real-life patients.

Detailed Description
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The project was approved by the Management in the Municipality of Frederikshavn. According to Danish legislation, no formal permission from the national or regional Committee on Health Research Ethics was required for this type of study, as patients were not treated inferior to usual care and no biological material was collected. It was conducted as a quality improvement project and informed consent was not required for the specific data collected. The study is in compliance with the General Data Protection Regulation and a part of North Denmark Region's record of processing activities (K2023-008).

Official Title
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Effective Deprescribing in Primary Care Without Deterioration of Health-related Outcomes

Conditions
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Chronic Disease

Intervention / Treatment
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* Other: Medication review


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: new residents and residents that had not yet attended a consultation focusing on pharmacological treatment in The Chronic Care Model. patients were invited for the consultation focusing on pharmacological treatment in the month of their birthday and, thereby, included randomly and consecutively throughout the study period. Exclusion Criteria: unable to collaborate on follow-up questionnaires

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 105 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Care home residents<br>The intervention was offered to new residents and residents that had not yet attended a consultation focusing on pharmacological treatment in The Chronic Care Model. | Other: Medication review<br>* Annual consultation focusing on pharmacological treatment. This specific consultation constituted the intervention. It included a structured review of the patient's health state, in addition to a structured medication review with a focus on appropriate medication and deprescribing.<br>* Other names: Medication review with focus on deprescribing;|
| Community-dwelling patients with chronic disease<br>Patients were invited for the consultation focusing on pharmacological treatment in the month of their birthday and, thereby, included randomly and consecutively throughout the study period. | Other: Medication review<br>* Annual consultation focusing on pharmacological treatment. This specific consultation constituted the intervention. It included a structured review of the patient's health state, in addition to a structured medication review with a focus on appropriate medication and deprescribing.<br>* Other names: Medication review with focus on deprescribing;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| self-reported health status | (on a scale from 1 to 10) | 4 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| general condition | (rated on a 5-point Likert Scale) | 4 months | 
| functional level | rated on a 5-point Likert Scale | 4 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Polypharmacy, Chronic disease management, Primary care, Medication review, Deprescribing