Analysis of the Causes of Redo Pull-through for Recurrent Constipation and the Risk Factors Affecting the Prognosis of the Hirschsprung's Disease and Allied Disorders

Study Overview
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Brief Summary
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The goal of this observational study is to conducted a comprehensive analysis of the factors contributing to redo- Pull-through surgery for constipation recurrence in Children who are suffering from Hirschsprun' s disease (HSCR) and its allied disorders (ADHD) . The main question[s] it aims to answer are: Our study focused on the treatment and prognosis of these conditions, drawing upon 16 years of patient data and clinical experiences What are the key risk factors affecting the prognosis of recurrent constipation patients undergoing repeat PT?

Official Title
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Analysis of the Causes of Redo Pull-through for Recurrent Constipation and the Risk Factors Affecting the Prognosis of the Hirschsprung's Disease and Allied Disorders

Conditions
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Surgery, Pediatric ALL

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients admitted to the department of pediatric surgery at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, between January 2005 and December 2021; HSCR and ADHD patients admitted due to constipation recurrence and requiring redo-PT. Exclusion Criteria: Patients undergoing staged surgeries or undergoing internal sphincterotomy; Patients with concomitant severe congenital anomalies such as Down syndrome; (3) Patients with incomplete postoperative follow-up data after redo-PT.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Acquire Aganglionosis (AA)<br> | |
| Intestinal Dysmotility (ID)<br> | |
| Anastomotic Complications (AC)<br> | |
| Intestinal Neurodevelopmental Impairment (INI)<br> | |
| Incomplete Resection of Affected Intestinal Segments (IRAIS)<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Participants with redo-pull-through surgery for recurrent constipation | After utilizing the terms Hirschsprung and Redo pull-through in searches across PubMed and Web of Science for references published between 1990 and 2023, and subsequent removal of duplicate and incomplete documents, we compiled clinical information from the remaining literature. This compilation facilitated a review of relevant literature on the causes of redo-PT for recurrent constipation, enabling an assessment of classification types, which we categorized into five groups: Incomplete Resection of Affected Intestinal Segments (IRAIS), Acquire Aganglionosis (AA), Intestinal Dysmotility (ID), Anastomotic Complications (AC), and Intestinal Neurodevelopmental Impairment (INI). | 1990-2023 | 
| Participants with and without postoperative complications | Group the data by gender, age groups, surgical techniques, and surgical approaches. Then, calculate the number of cases with and without postoperative complications | through study completion, an average of 33 year |