A Study of Gender-specific Impact Factors on Elderly Disability and Cognitive Impairment

Study Overview
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Brief Summary
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Elderly disability and cognitive impairment rates were different between elderly man and woman. Sex-specific risk factors and observed gender differences across the lifespan were associated with different degrees of cognitive and activity of daily living function decline between men and women. However, some of these viewpoint remains controversial. The aim of this study is to explore the gender differences and influencing factors of disability and cognitive impairment among the elderly.

Detailed Description
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With the rapid increase in the aging population in China, age-related cognitive impairment and disability has become a pressing public health concern. A number of large-scale studies in China and abroad have shown that the average life expectancy of women elderly is higher than men, but the rates of disability and cognitive impairment are higher. However, it is lack of exploration of the factors associated with the gender-specific of disability and cognitive impairment. The aim of this study is to explore the gender differences and influencing factors of disability and cognitive impairment among the elderly. A retrospective cohort based on Shandong Provincial Qianfoshan Hospital Healthcare Big Data Platform is conducted to collect data. And the data from the China Longitudinal Healthy Longevity Survey (CLHLS) was used to further validate the results.

Official Title
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Gender-specific Impact Factors on Elderly Disability and Cognitive Impairment: A Retrospective Cohort Study

Conditions
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Aging

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1.The elderly aged 65 and above. Exclusion Criteria: Lack of diagnostic information. Missing key influencing factors such as gender and age. Hearing or linguistic impairment. Comatose patients.

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Retrospective cohort based on Shandong Provincial Qianfoshan Hospital Healthcare Big Data Platform<br>A retrospective cohort based on Shandong Provincial Qianfoshan Hospital Healthcare Big Data Platform is conducted to collect data and to explore the gender differences and influencing factors of disability and cognitive impairment among the elderly. | |
| Retrospective cohort from CLHLS<br>The data from the China Longitudinal Healthy Longevity Survey (CLHLS) was used to further validate the results. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disability | We identified disability according to the Katz index. This Katz index includes six activities of daily life: bathing, transferring, dressing, eating, toileting, and continence. Disability was defined as needing help with at least one of the six activities of daily life. | 2002-2023 | 
| Cognitive impairment | The main outcome was assessed by the Chinese version of the Mini-Mental State Examination (CMMSE).For participants who had never received education, an MMSE score of 17 or less was considered as cognitive impairment; for those who had less than 6 years of education, an MMSE score of 20 or less was considered as cognitive impairment; and for those who had more than 6 years of education, an MMSE score of 24 or less was considered as cognitive impairment. For each level of education, scores above the threshold were considered cognitively normal. | 2002-2023 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Elderly, Disability, Cognitive impairment, Gender-specific