Understanding Ayurveda Disease Conditions and Treatment Responses

Study Overview
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Brief Summary
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The goal of this observational study is to assess Prakriti & Vikriti in patients visiting OPD of IIISM department, SRM hospital. The main question[s] it aims to answer are: To evaluate Prakriti & Vikriti of patients using Prakriti & Vikriti questionnaire and with digital devices To correlate the determined Prakriti and Vikriti with the doctor's assessment along with clinical and biochemical parameters Participants will be advised to follow the treating physician's advice on medicines

Detailed Description
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The Ayurveda is an ancient documented medical system originated in India. The Ayurveda stratified humans into 7 broad categories based on the phenotype features viz. Vata, Pitta, Kapha, Vatapitta, Vatakapha, Kaphapitta and Vatapittakapha Prakriti types. Also, the features of the disease conditions are clearly described based on the predominance of Vata, Pitta and Kapha or its combinations. Presently, the identification of Prakriti type and Vikriti status are basically subjective assessment. This study proposes to integrate the subjective assessment with objective digital signal parameters. This digital signatures would be useful in ML / AI based assessment and prediction of Prakriti type and Vikriti status of the patients.

Official Title
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Prediction of Ayurveda Prakriti and Vikriti Using Automatic Questionnaire and Digital Sensors

Conditions
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Type2diabetes, Rheumatoid Arthritis, Osteo Arthritis Knee, Skin Diseases, Gastric Ulcer, Neurodegenerative Diseases

Intervention / Treatment
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* Drug: Personalized Ayurveda treatment protocol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients of various diseases visiting the OPD Exclusion Criteria: Pregnancy and lactating females

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Personalized Ayurveda treatment protocol|The treating physician decided and advised personalized Ayurveda treatment protocol based on disease and patient's condition|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in Complete blood count at 12 week | complete blood count, which includes red blood cell count, neutrophil count, eosinophil count, basophil count, lymphocyte count, monocyte count, and platelet count is a standard investigation to measure the abnormality in blood cells | 12 weeks | 
| Serum Urea | Measures urea, which is a investigation to measure the abnormality in kidney function | 12 weeks | 
| Serum creatinine | Measures creatinine, which is a investigation to measure the abnormality in kidney function | 12 weeks | 
| Lipid Profile | Lipid profile test includes Total cholesterol, LDL, HDL, Triglycerides, and non-HDL is a investigation to measure the abnormality in lipids | 12 weeks | 
| Cytokines (TNF- alpha, IFN-gamma, IL-1, IL-4, IL-6, IL-10) | Cytokines are inflammatory markers, measured to identify treatment effect in inflammation | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pulse Plethysmography signals (PPG) - Finger PPG sensor | PPG is measured to identify pulse wave form changes before and after treatment | 12 weeks |