Effect of Strength Versus Endurance Training on Muscle Damage in Gym Athletes on Caffeine Supplementation.

Study Overview
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Brief Summary
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Dietary supplements to enhance exercise and athletic performance come in a variety of forms, including tablets, capsules, liquids, powders, and bars. Many of these products contain numerous ingredients in varied combinations and amounts. Among the more common ingredients are amino acids, protein, creatine, and caffeine

Detailed Description
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Caffeine is a popular nutritional supplement among gym athletes. It is frequently used as an ergogenic aid to improve physical performance, delay fatigue, and increase muscle power. This research aims to evaluate the effectiveness of caffeine through the blood sample test (Serum CK, LDH levels, AST levels) on muscle damage of gym athletes who are performing aerobic and strength training. This study would help understand the effects of strength training and endurance training on muscle damage in gym athletes who are consuming caffeine and to check the serum enzymes level of both groups who are on strength training and those who are on endurance level training, therefore, this study would help determine which athletes should be careful while consuming caffeine for a particular exercise regimen

Official Title
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Effect of Strength Versus Endurance Training on Muscle Damage in Gym Athletes on Caffeine Supplementation.

Conditions
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Muscle Damage

Intervention / Treatment
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* Other: Strength Training with Caffeine
* Other: Endurance Training with Caffeine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male gym athletes Age: 18-40 years Athletes with at least three days training session per week Exclusion Criteria: Athletes already on caffeine supplementation Athletes with above normal serum enzyme levels

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Randomized Crossover Trial
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Strength Training<br>Strength training exercises along with caffeine supplementation | Other: Strength Training with Caffeine<br>* The intervention protocol consists of 5 types of strength training exercises. The following exercises will be performed for the strength training group: bench press (3 sets of 10 reps) biceps curl (3 sets of 10 reps) triceps pushdown (3 sets of 10 reps) leg press (3 sets of 10 reps) leg extension (3 sets of 10 reps) Strength training would be performed in 3 sets of 10 repetitions with 2 minutes of rest between each exercise. This protocol will be performed in a 30-40-minute session. 10-15 minutes of light warm-up activities will be performed before the start of each exercise session. The intervention sessions would be carried out with a 3-5-day gap between the two intervention sessions.<br>|
| Active Comparator: Endurance Training<br>Endurance training exercises along with caffeine supplementation | Other: Endurance Training with Caffeine<br>* The intervention protocol consists of 3 types of endurance training exercises. The following exercises will be performed by this group: Cycling (15 min) Running (20 min) Rowing (10 min) The intervention sessions would be carried out with a 3-5-day gap between the two intervention sessions.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum CK Levels | Serum CK level is the amount of an enzyme called creatine kinase (CK) in the blood. CK is a type of protein present in the muscle cells in human body need which is essential for proper functioning. Levels of CK can rise after a heart attack, skeletal muscle injury, or strenuous exercise | Pre-intervention, after 24 hours of the intervention, after 3 days before second intervention, and after 24 hours of the second intervention | 
| Serum LDH levels | Lactate Dehydrogenase (LDH) is enzyme found in almost every cell of the human body, including your blood, muscles, brain, kidneys, and pancreas. | Pre-intervention, after 24 hours of the intervention, after 3 days before second intervention, and after 24 hours of the second intervention | 
| Serum AST levels | Aspartate aminotransferase (AST) are enzymes found mainly in the liver, but also found in red blood cells, heart cells, muscle tissue and other organs, such as the pancreas and kidneys. | Pre-intervention, after 24 hours of the intervention, after 3 days before second intervention, and after 24 hours of the second intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rating of fatigue scale/Numeric Rating Scale-Fatigue | This rating-of-fatigue (ROF) scale has been developed which can track the intensity of perceived fatigue in a variety of contexts. | Pre-intervention, after 24 hours of the intervention, after 3 days before second intervention, and after 24 hours of the second intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Caffeine, Creatine Kinase, Endurance Training, Fitness Centers, Skeletal Muscle, Strength Training