Acute Influence of Resveratrol Supplementation and Beet Extract in Recovery After Exercise in Coronary Paths

Study Overview
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Brief Summary
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Introduction: Most cardiovascular diseases (CVD) can be prevented and controlled by adopting lifestyle changes, such as regular physical exercise and nutrition. Resveratrol and beverage extract promote beneficial health effects due to their nutritional properties. Objective: to analyze the effects of resveratrol supplementation and withdrawal extract on post-exercise recovery in coronary heart disease patients. Methods: men diagnosed with ischemic coronary artery disease will undergo four exercise protocols consisting of 30 minutes of aerobic exercise on an ergometric treadmill, with 5 minutes of warm-up, intensity of 30% of the heart rate reserve (HRR), followed by 25 minutes at intensity 60% of FCR and for a final 30 minutes of recovery in the supine position. Before each exercise protocol, all volunteers will consume: 500 mg of placebo (starch), or 500 mg of beetroot, or 500 mg of resveratrol and will also consume resveratrol and drink (500 mg each) 30 minutes before exercise. , the order of each supplementation will be done randomly. Cardiorespiratory parameters and heart rate variability (HRV) will be assessed at different times throughout the experimental procedure. To analyze the moments (rest versus recovery), the Bonferroni post-test will be used for parametric distribution or the Dunn post-test for non-parametric distribution. Statistical significance will be calculated at 5% for all analyses.

Official Title
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Acute Influence of Resveratrol Supplementation and Beet Extract in Recovery After Exercise Submaximal Aerobic in Coronary Paths: a Study Prospective, Randomized Placebo-controlled

Conditions
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Coronary Artery Disease, Autonomic Nervous System Disease, Blood Pressure, Heart Rate

Intervention / Treatment
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* Other: Placebo Protocol
* Other: Protocol Beet
* Other: Protocol Resveratrol
* Other: Protocol Beet and Resveratrol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult men over 45 years of age diagnosed with ischemic coronary artery disease and with preserved left ventricular function (above 50%), confirmed by a previous echocardiogram Exclusion Criteria: Volunteers who present at least one of the following characteristics will be excluded: smokers alcohol drinkers those who did not attend a cardiovascular rehabilitation program for at least 3 months prior to data collection individuals who have known infections, metabolic and respiratory diseases that could interfere in cardiac autonomic control, unstable angina, uncontrolled hypertension, significant valvular disease, uncontrolled metabolic disease (e.g., uncontrolled diabetes and thyroid disease)

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 79 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo Protocol<br>exercise and placebo capsules 500 mg (starch) | Other: Placebo Protocol<br>* ingestion of 500 mg of starch following 30 minutes of exercise (treadmill)<br>* Other names: 500 mg of starch;|
| Experimental: Protocol Beet<br>exercise and beet extract 500 mg | Other: Protocol Beet<br>* ingestion of 500 mg of beet extect following 30 minutes of exercise (treadmill)<br>* Other names: 500 mg of beet extract;|
| Experimental: Protocol Resveratrol<br>exercise and resveratrol capsules 500 mg | Other: Protocol Resveratrol<br>* ingestion of 500 mg of resveratrol following 30 minutes of exercise (treadmill)<br>* Other names: 500 mg of resveratrol;|
| Experimental: Protocol Beet and Resveratrol<br>exercise and beet extract 500mg and resveratrol capsules 500 mg | Other: Protocol Beet and Resveratrol<br>* ingestion 500 mg of beet extect and 500 mg of resveratrol following 30 minutes of exercise (treadmill)<br>* Other names: 500 mg of beet extect and 500 mg of resveratrol;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate variability (HRV) | Time and frequency domain of HRV | through study completion, an average of 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood Pressure | Systolic Blood Pressure and Diastolic Blood Pressure | through study completion, an average of 1 hour |