Fibrinogen Concentrate and Placenta Acreta Spectrum

Study Overview
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Brief Summary
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The aim of this study is to evaluate the relationship between fibrinogen use and bleeding in patients who underwent cesarean section with a prediagnosis of PAS. The key question(s) it aims to answer are: [Does the use of fibrinogen concentrate reduce bleeding in PAS patients?] Patients who had a cesarean section with a pre-diagnosis of PAS were analyzed retrospectively. The choice of anesthesia applied to the patients and the relationship between the use of blood products and bleeding were evaluated.

Detailed Description
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Our study was designed as a retrospective randomized study. Patients aged 20-50 years and >34 weeks of gestation who accepted the birth with a cesarean section with a pre-diagnosis of PAS were evaluated retrospectively. examined. were randomized into 2 groups, 53 patients in each group: group1: GNF : the group without fibrinogen concentrate Group 2: GF: the group with fibrinogen concentrate

Official Title
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Is the Use of Fibrinogen in Cesarean Section Related to Bleeding and Blood Product in Patients With Placenta Accreta Spectrum?: a Retrospective Randomized Study

Conditions
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Obstetric Anesthesia Problems, Placenta Accreta

Intervention / Treatment
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* Procedure: the group without fibrinogen concentrate (GNF) , the group with fibrinogen concentrate (GF)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 20-50 years PAS pre-diagnosed pregnant women >34 weeks of pregnancy Those with normal renal functions Exclusion Criteria: Patients with renal insufficiency Those with <34 weeks of gestation Pregnant women with missing data

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: retrospective randomized study
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: grup 1: the group without fibrinogen concentrate (GNF)<br>grup 1: the group without fibrinogen concentrate (GNF) | Procedure: the group without fibrinogen concentrate (GNF) , the group with fibrinogen concentrate (GF)<br>* the group without fibrinogen concentrate (GNF, ) the group with fibrinogen concentrate (GF)<br>* Other names: group 2: the group with fibrinogen concentrate (GF);|
| Experimental: Grup 2: the group with fibrinogen concentrate<br>Grup 2: the group with fibrinogen concentrate | Procedure: the group without fibrinogen concentrate (GNF) , the group with fibrinogen concentrate (GF)<br>* the group without fibrinogen concentrate (GNF, ) the group with fibrinogen concentrate (GF)<br>* Other names: group 2: the group with fibrinogen concentrate (GF);|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Laboratory hemoglobin level(g/dl) | Our primary aim was to evaluate the postoperative day 1(POD 1) hemoglobin values(g/dl). | Change from preoperative to postoperative day 1(POD 1) hemoglobin values (g/dl). | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The intensive care unit (ICU) admission and length of stay. | The secondary aim was to investigate the intensive care unit (ICU) admission and length of stay. | postoperatively up to 1 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fibrinogen concentrate, obstetric anesthesia, plasenta acreata spectrum, postpartum hemorrhage