Effects of Preoperative Rehabilitation on Tendon Healing and Bone Mineral Density After ACLR

Study Overview
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Brief Summary
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To explore the effect of preoperative exercise rehabilitation on bone mineral density, tendon bone healing, change of cartilage, and gait feature in patients with anterior cruciate ligament rupture.

Detailed Description
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Anterior Cruciate Ligament (ACL) injury is one of the most common sports injuries. It is a serious knee injury. The fracture of ACL can cause functional instability of knee joint, damage of meniscus and articular cartilage, and even induce knee osteoarthritis and other diseases. It has great influence on knee joint and even lower limb function of patients. Arthroscopic ACL reconstruction has become the first choice in clinical treatment of ACL fracture. ACL fracture can cause local knee joint osteoporosis, and reconstruction surgery can also affect tendon bone healing, bone canal enlargement, rehabilitation period, gait, articular cartilage degradation, etc. This study intends to conduct preoperative rehabilitation intervention for young people with anterior fork rupture, and explore the effects of exercise rehabilitation on knee bone mineral density, muscle strength, proprioceptive ability and other aspects after ACL rupture, as well as the effects of knee bone mineral density, tendon bone healing, bone tunnel aperture, motor function, gait characteristics and cartilage degradation after reconstruction.

Official Title
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A Study on the Effect of Exercise Rehabilitation on Bone Mineral Density and Reconstruction Ligament Tendon Bone Healing After ACL Rupture

Conditions
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Anterior Cruciate Ligament Rupture

Intervention / Treatment
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* Behavioral: exercise rehablitation
* Behavioral: routine treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 40 years old, diagnosed ACL rupture by MRI; The first unilateral ACL rupture requires reconstruction at our hospital; Greater than 6 weeks from trauma and within 6 months. Exclusion Criteria: Be older than 40 years, or less than 18 years old Within 8 weeks of the onset of the trauma, or more than 1 year Severe injury to other knee ligaments History of knee trauma

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: experimental group<br>Before ACL reconstruction,40 minutes of rehabilitation training was performed 3 times a week for 6 weeks, and gotted regular treatment. The ACL reconstruction was followed by a 0.5 year rehabilitation. | Behavioral: exercise rehablitation<br>* Preoperative exercise rehabilitation in experimental group was performed.<br>|
| Active Comparator: control group<br>Regular rehabilitation training was not performed before ACL reconstruction, got regular treatment. The ACL reconstruction was followed by a 0.5 year rehabilitation. | Behavioral: routine treatment<br>* The control group receives conventional treatment preoperative.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Grade of tendon bone healing | tendon bone healing by knee MRI | At 6 monthes post operation. | 
| Grade of tendon bone healing | tendon bone healing by knee MRI | At 1 year post operation. | 
| balanced capacity | Y balance test | At preoperative. | 
| balanced capacity | Y balance test | At 6 monthes post operation. | 
| balanced capacity | Y balance test | At 1 year post operation. | 
| knee T1 rho value | knee T1 rho value by functional MRI | At 6 months post operation. | 
| knee T1 rho value | knee T1 rho value by functional MRI | At 1 year post operation. | 
| knee T2 value | knee T2 rho value by functional MRI | At 6 months post operation. | 
| knee T2 value | knee T2 rho value by functional MRI | At 1 year post operation. | 
| knee extension angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 6 months post operation. | 
| knee extension angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 1 year post operation. | 
| Graft maturity | tendon bone healing by knee MRI | At 6 monthes post operation. | 
| Graft maturity | tendon bone healing by knee MRI | At 1 year post operation. | 
| bone mineral density | bone mineral density by knee DEX | At preoperative. | 
| bone mineral density | bone mineral density by knee DEX | At 6 monthes post operation. | 
| bone mineral density | bone mineral density by knee DEX | At 1 year post operation. | 
| isokinetic muscle strength | Knee isokinetic strength test | At preoperative. | 
| isokinetic muscle strength | Knee isokinetic strength test | At 6 monthes post operation. | 
| isokinetic muscle strength | Knee isokinetic strength test | At 1 year post operation. |