Effects of Omega-3 and Whey Protein Supplementation on Lean Mass in Older Adults

Study Overview
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Brief Summary
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To evaluate the effect of omega-3 supplementation combined with whey protein intake on lean mass and strength gains in older adults performing resistance exercise. Participants will be randomized into the 4 groups. The placebo group will receive 4 g per day of corn oil and 40 g per day of maltodextrin. The omega 3 + placebo group will receive 4 g per day of fish oil and 40 g per day of maltodextrin. The whey protein + placebo group will receive 40g per day of whey and 4g per day of corn oil. The omega 3 + whey group will receive 4g per day of fish oil and 40g per day of protein. All will perform the same exercise protocol for 12 weeks

Official Title
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Effects of Omega-3 and Whey Protein Supplementation on Lean Mass and Strength Gains in Older Adults Performing Resistance Exercise: A Randomized, Double-Blind and Placebo-Controlled Study

Conditions
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Sarcopenia

Intervention / Treatment
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* Dietary Supplement: Placebo Group
* Dietary Supplement: Whey Protein + Placebo
* Dietary Supplement: Omega 3 + Placebo
* Dietary Supplement: Omega 3 + Whey Protein


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Postmenopausal women (at least 1 year of menstrual interruption, self-reported); To be able to practice strength exercises; To be able to carry out supplementation; Do not present physical, orthopedic or cardiovascular complications that prevent the performance of physical exercises; No history of stroke or acute myocardial infarction; Not being a smoker and/or alcoholic; Do not perform hormone replacement therapy; Do not use anti-inflammatory drugs; To have normal kidney function; To submit a medical certificate of health that proves that the individual is able to perform exercises. Exclusion Criteria: Do not provide the necessary information for the development of the study; Individuals with diseases previously diagnosed and undergoing treatment, such as type II diabetes mellitus, cancer, rheumatoid arthritis, high blood pressure, dyslipidemia, cardiovascular, and kidney and/or liver diseases.

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo Group<br>Group supplemented with maltodextrin (40g/day) and corn oil (4g/day). All groups will undergo a training program with strength exercises for 12 weeks | Dietary Supplement: Placebo Group<br>* The placebo group will receive 4 g per day of corn oil and 40 g per day of maltodextrin.<br>|
| Experimental: Whey Protein + Placebo<br>Group supplemented with isolated whey protein (40g/day) and corn oil (4g/day). All groups will undergo a training program with strength exercises for 12 weeks. | Dietary Supplement: Whey Protein + Placebo<br>* The whey protein + placebo group will receive 40g per day of whey and 4g per day of corn oil.<br>|
| Experimental: Omega 3 + Placebo<br>Group supplemented with omega-3 (4g/day) and maltodextrin (40g/day). All groups will undergo a training program with strength exercises for 12 weeks. | Dietary Supplement: Omega 3 + Placebo<br>* The omega 3 + placebo group will receive 4 g per day of fish oil and 40 g per day of maltodextrin.<br>|
| Experimental: Omega 3 + Whey Protein<br>Group supplemented with omega-3 (4g/day) and whey protein (40g/day). All groups will undergo a training program with strength exercises for 12 weeks. | Dietary Supplement: Omega 3 + Whey Protein<br>* The omega 3 + whey group will receive 4g per day of fish oil and 40g per day of protein.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in lean mass (kg) using ultrasound and electrical bioimpedance in postmenopausal women |  | up to 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in strength (kg) using dynamometer in postmenopausal women |  | up to 12 weeks |