The Association of Cardiac Valve Calcification and 1-year Mortality After Lower-extremity Amputation in Diabetic Patients

Study Overview
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Brief Summary
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The goal of this observational study is to learn about the association between cardiac valve calcification and the 1-year mortality after lower-extremity amputation in diabetic patients. Diabetic patients requiring lower-extremity amputation were retrospectively studied. Preoperative detailed anamnesis was taken. Cardiac valve calcification was assessed using echocardiography at baseline. One-year follow-up was conducted and included clinical visits, hospital record assessment, and telephone reviews to obtain the survival status of patients. Researchers compare the survival group to the mortality group to study the relationship between the cardiac valve calcification and mortality.

Detailed Description
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This study aimed to investigate the association between cardiac valve calcification and 1-year mortality in diabetic patients after lower-extremity amputation. The investigator recruited consecutive patients who were admitted to the Sun Yat-sen Memorial Hospital for diabetic foot ulcers that needed amputation surgery. Clinical characteristics of each patient and the laboratory examination were collected before surgery. Cardiac valve calcification was assessed at baseline. This study obtained the survival status of patients within one year through outpatient follow-up and telephone follow-up. Researchers compared the survival group to the mortality group to see if the mortality group had a higher prevalence of heart valve calcification.

Official Title
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The Association of Cardiac Valve Calcification and 1-year Mortality After Lower-extremity Amputation in Diabetic Patients: a Retrospective Study

Conditions
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Amputation, Diabetic Foot, Valve Disease, Aortic, Valve Heart Disease

Intervention / Treatment
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* Other: calcified cardiac valve


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Had echocardiography at baseline With diabetic foot ulcers that required amputation after orthopedist's assessment Exclusion Criteria: Fractures due to traumatic reasons that required extremity amputation Amputation level below the ankle Severe sepsis that required vasoactive agent treatment Rheumatic heart disease Heart valve surgery history

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| survival group<br>The patients who survived more than 1-year after amputation surgery. | Other: calcified cardiac valve<br>* patients have cardiac cardiac valve before surgery<br>|
| mortality group<br>The patients who were dead within 1-year after amputation surgery. | Other: calcified cardiac valve<br>* patients have cardiac cardiac valve before surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The proportion of cardiac valve calcification between survival group and mortality group | The prevalence of calcified heart valve diseases was compared between the mortality group and survival group. | 2017-12-1 |