Effects of a Single Dose of Wild Blueberries on Mood and Executive Function in Healthy Emerging Adults

Study Overview
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Brief Summary
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This study aims to investigate whether consuming a drink containing powdered blueberries (equivalent to 150 g of fresh fruit) can improve mood and executive function in healthy emerging adults.

Detailed Description
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The present study will examine the psychological effects of a single dose of freeze-dried wild blueberries using a randomized, single-blind, placebo-controlled design. A total of 80 participants will be randomly allocated to consume either a drink prepared with 22 g blueberry powder or a drink prepared with 22 g placebo powder matched for macronutrients, flavour and colour.

Official Title
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Effects of a Single Dose of Wild Blueberries on Mood and Executive Function in Healthy Emerging Adults: a Single-Blind, Randomized Controlled Trial

Conditions
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Mood, Affect, Executive Function

Intervention / Treatment
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* Dietary Supplement: Blueberry drink
* Dietary Supplement: Placebo drink


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18 to 25 years of age Exclusion Criteria: Any medically significant condition or mental health disorder (e.g. diabetes, endocrine or gastrointestinal disorders) Taking medication (excluding hormonal contraception or medication for asthma/seasonal allergies) Allergy to blueberries or any other Vaccinium species

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Standard two-arm trial with a placebo arm and active intervention arm
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Blueberry drink<br> | Dietary Supplement: Blueberry drink<br>* 22 g freeze-dried wild blueberry (Vaccinium angustifolium) powder mixed with 250 ml water.<br>|
| Placebo Comparator: Placebo drink<br> | Dietary Supplement: Placebo drink<br>* 22 g placebo powder matched for macronutrients, color, and flavor mixed with 250 ml water.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Positive affect as measured by PANAS-X | Positive affect will be calculated by adding the values of the 21 positive items of the Positive and Negative Affect Schedule-X and the additional item motivated. Thus, the scale will range from 0 to 88 points with higher scores indicating better mood. | 1.5 hours post-ingestion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Negative affect as measured by PANAS-X | Negative affect will be calculated by adding the values of the 25 negative items of the Positive and Negative Affect Schedule-X. Thus, the scale will range from 0 to 100 points with higher scores indicating worse mood. | 1.5 hours post-ingestion | 
| Executive function (accuracy) | A task-switching test will be used to assess cognitive flexibility when switching between two predictable tasks requiring simple numerical decisions. The main outcome of interest is the average accuracy (0 to 100%). | 1.5 hours post-ingestion | 
| Reaction time | The average reaction time on correct trials of the task-switching test (in milliseconds). | 1.5 hours post-ingestion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Blueberry, Anthocyanins