Effect of Different Heparinization Schemes on Prognosis of Intracranial Aneurysm

Study Overview
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Brief Summary
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The goal of this clinical trial is to compare intracranial aneurysm patients. The main question it aims to answer are: Which heparinization regimen is most beneficial to patients during surgery for intracranial aneurysms. Participants will be randomized to different intraoperative heparinization regimens: (i) 50 U/kg intravenous (IV) at 1-h intervals reduced by half to a minimum of 1000 u/h; (ii) 70 U/kg IV at 1-h intervals reduced by half to a minimum of 1000 u/h. MRI will be performed within 72 h after surgery, and the DWI sequence of MRI will be analyzed. If there is a comparison group: Researchers will compare different intraoperative heparinization protocol groups to see which dose of intraoperative heparin has the best prognosis for use.

Official Title
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Effect of Heparinization on Intracranial Aneurysm

Conditions
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Intracranial Aneurysm

Intervention / Treatment
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* Drug: Heparin sodium


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Greater than 18 years old, less than 75 years old Patients with unruptured intracranial aneurysm were confirmed by DSA. Coagulation function should be normal in the enrolled patients. Exclusion Criteria: Dissection aneurysm, blister aneurysm, moyamoya disease or arteriovenous malformation. Previous use of antithrombotic drugs (including anticoagulant or antiplatelet aggregation drugs).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Low-dose group<br>The initial dose was 50U/kg intravenous injection, and the dosage was halved by intravenous injection every 1 hour to the minimum 1000u/h. The medication will be discontinued at the end of the procedure. | Drug: Heparin sodium<br>* Intravenous heparin was administered during intracranial aneurysm embolization with a guide catheter and discontinued at the end of the procedure.<br>|
| Experimental: High-dose group<br>The initial dose was 70U/kg intravenous injection, and the dosage was halved by intravenous injection every 1 hour to the minimum 1000u/h. The medication will be discontinued at the end of the procedure. | Drug: Heparin sodium<br>* Intravenous heparin was administered during intracranial aneurysm embolization with a guide catheter and discontinued at the end of the procedure.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Size of the ischemic focus | Cranial MRI will be performed on postoperative patients within 24 hours. The presence of high signal on diffusion weighted imaging sequences indicated the occurrence of cerebral infarction. | This will be evaluated within 24 hours after the procedure. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Intracranial Aneurysm