Telerehabilitation Program and Detraining in Patients With Post-COVID-19 Sequelae

Study Overview
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Brief Summary
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The primary objective of this study is to evaluate the effects of a 15-week home telerehabilitation program and a detraining period on cardiorespiratory fitness and muscular efficiency in patients with post-COVID-19 sequelae compared to a control group of COVID-19 patients. We hypothesize that cardiorespiratory fitness and muscular efficiency significantly improve in patients who carry out the home telerehabilitation program. However, the cardiorespiratory and muscular adaptations achieved and tolerance to exercise are lost over time as an effect of detraining.

Official Title
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Effects of a Telerehabilitation Program and Detraining on Cardiorespiratory Fitness in Patients With Post-COVID-19 Sequelae

Conditions
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COVID-19 Acute Respiratory Distress Syndrome

Intervention / Treatment
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* Other: Telerehabilitation program


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age > 18 years molecular diagnosis (reverse transcription polymerase chain reaction [RT-PCR]) of infection by SARS-CoV-2 post-COVID-19 symptomatology Exclusion Criteria: severe neurological disease active oncological disease neuromuscular disease and/or orthopedic disorders impeding normal development of cardiopulmonary exercise test the absence of signed informed consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Supervised home telerehabilitation program<br>COVID-19 patients will perform a total of 15 weeks of a telerehabilitation program combined with aerobic and strength exercises using the circuit training methodology. COVID-19 patients will carry out 3 weekly sessions on non-consecutive days to avoid unnecessary overload and maximize the adaptations, completing a total of 45 sessions | Other: Telerehabilitation program<br>* The supervised telerehabilitation program will be performed in the home of each patient and supervised by an experienced physiotherapist with more than 4 years of clinical experience in therapeutic exercise for chronic diseases.<br>|
| No Intervention: non-supervised control group<br>COVID-19 patients that will not perform the telerehabilitation program | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiorespiratory fitness: absolute oxygen uptake | absolute peak oxygen uptake in L/min | 1 week per group | 
| Cardiorespiratory fitness: relative oxygen uptake | relative peak oxygen uptake in L/min | 1 week per group | 
| Exercise capacity during cardiopulmonary exercise test | Exercise time in minutes and seconds | 1 week per group | 
| Mechanical efficiency | Delta efficiency in percentage | 1 week per group | 
| Ventilatory efficiency | VE/VCO2 slope | 1 week per group | 
| Power output during pedaling | Power output in watts | 1 week per group | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Respiratory exchange ratio | RER | 1 week per group | 
| Minute ventilation | Ventilation in L/min | 1 week per group | 
| ventilatory equivalent for oxygen | VE/VO2 | 1 week per group | 
| ventilatory equivalent for carbon dioxide | VE/VCO2 | 1 week per group | 
| End-tidal partial pressure of oxygen | PetO2 in mmHg | 1 week per group | 
| end-tidal partial pressure of carbon dioxide | PetCO2 in mmHg | 1 week per group | 
| Weight of COVID-19 patients | Weight in kg | 1 week per group | 
| Height of COVID-19 patients | Height in meters | 1 week per group | 
| Body mass index of COVID-19 patients | BMI in kg/m2 | 1 week per group |