Performance of Spectral CT-scan in Patients With Metastatic Colorectal Cancer: a Prospective Multicentre Study

Study Overview
=================
Brief Summary
-----------------
Spectral CT is a rapidly expanding imaging modality that allows a reduction in iodine dose and irradiation compared to conventional scanning. It uses the difference in attenuation of the material according to the two different energy levels of the incident x-ray beams. The dual-energy scanner has a wide range of clinical applications, particularly in abdominal imaging.

Detailed Description
-----------------
First of all, the virtual creation of mono-energy images between 40 and 140 keV has shown subjective and objective improvement of tumor detection of hypovascular lesions using low energies (40keV). It has been shown to be of interest in vascular and cardiac imaging, and to reduce artefacts in bone imaging. However, its performance in oncology analysis has been little studied. The selection of patients for peritoneal and hepatic carcinosis surgery is fundamental, as surgery allows a prolongation of survival, but are associated with a non-negligible morbi-mortality rate. Spectral CT provides improved detection of peritoneal carcinosis and liver metastases of colorectal cancer compared to conventional CT acquisition.

Official Title
-----------------
Performance of Spectral CT-scan in Patients With Metastatic Colorectal Cancer: a Prospective Multicentre Study

Conditions
-----------------
Colo-rectal Cancer

Intervention / Treatment
-----------------
* Other: CT Images


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients followed for colorectal cancer with synchronous or metachronous liver metastases and/or peritoneal carcinosis Patients with a curative surgical resection plan Exclusion Criteria: Patients with non-metastatic colorectal cancer Patients treated with chemotherapy without surgical plans Patients with colorectal cancer with extra-hepatic and extra-peritoneal metastases alone (e.g. lung, bone)
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with Colo-rectal Cancer<br>Patients with Colo-rectal Cancer will be included. | Other: CT Images<br>* Analysis of CT images of peritoneal and/or liver metastases from colorectal cancer<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of peritoneal and hepatic lesion mapping between spectral scanning and conventional scanning | Comparison of peritoneal and hepatic lesion mapping between spectral scanning (monoenergetic acquisitions, iodine mapping, etc.) and conventional scanning (acquisition obtained during spectral acquisition). | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of evaluation of response to chemotherapy (if indicated) in RECIST 1.1 and Radiomics | Collection of demographic, biological and surgical data. | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Colo-rectal cancer, spectral CT scan, liver metastases, peritoneal carcinosis