Vitamin D, HbA1c and Vitamin B12 Levels in Patients

Study Overview
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Brief Summary
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Abstract Aim: to compare the serum vitamin D, HbA1c and vitamin B12 levels in patients with gingivitis and four different periodontitis stages diagnosed according to the 2017 Periodontal Disease Classification. Materials and methods: A total of 606 (378 Female, 228 Male) patients were included in the study. The periodontal status of the patients was diagnosed with gingivitis, stage 1,2,3 and 4 periodontitis groups were formed. HbA1c, vitamin D and vitamin B12 values of the patients were compared and analyzed. Result: Conclusion:

Detailed Description
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bstract Aim: to compare the serum vitamin D, HbA1c and vitamin B12 levels in patients with gingivitis and four different periodontitis stages diagnosed according to the 2017 Periodontal Disease Classification as determined by the American Academy of Periodontology and the European Federation of Periodontology (AAP-EFP) Materials and methods: A total of 606 (378 Female, 228 Male) patients were included in the study. The periodontal status of the patients was diagnosed with gingivitis, stage 1,2,3 and 4 periodontitis groups were formed. HbA1c, vitamin D and vitamin B12 values of the patients were compared and analyzed.

Official Title
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Serum Vitamin D, HbA1c and Vitamin B12 Levels in Patients With Gingivitis and Periodontitis Stages

Conditions
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Serum HbA1c and Vitamin D, Vitamin B12 Values in Periodontal Diseases

Intervention / Treatment
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* Diagnostic Test: HbA1c, Vitamin D, Vitamin B12


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients diagnosed with gingivitis or periodontitis with complete periodontal diagnostic data (Gingival Index(Löe, 1967), Plaque Index(Löe, 1967), Periodontal pocket depths(PD), Clinical Attachment loss (CAL), Radiological data- Interdental Bone loss (IBL) data Non-smoker Vit D, HbA1c and B12 vit in blood on the date of application to the clinic and/or in the last 3 months. Patients with data on values were included in the study. Exclusion Criteria: Patients with missing data and not allowing data use Smoker The data of pregnant and lactating patients were not included in the study.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Gingivitis<br>0% interdental bone loss | Diagnostic Test: HbA1c, Vitamin D, Vitamin B12<br>* Serum HbA1c, Vitamin D, Vitamin B12 values of the patients who applied for gingival treatment in the last 3 months from the date of application were found from the hospital archive and serum was not taken from the patients again for the study.<br>|
| Stage 1 periodontitis<br>0-15% interdental bone loss | Diagnostic Test: HbA1c, Vitamin D, Vitamin B12<br>* Serum HbA1c, Vitamin D, Vitamin B12 values of the patients who applied for gingival treatment in the last 3 months from the date of application were found from the hospital archive and serum was not taken from the patients again for the study.<br>|
| Stage 2 Periodontitis<br>15-33% interdental bone loss | Diagnostic Test: HbA1c, Vitamin D, Vitamin B12<br>* Serum HbA1c, Vitamin D, Vitamin B12 values of the patients who applied for gingival treatment in the last 3 months from the date of application were found from the hospital archive and serum was not taken from the patients again for the study.<br>|
| Stage 3 Periodontitis<br>>33% interdental bone loss with potential for additional tooth loss | Diagnostic Test: HbA1c, Vitamin D, Vitamin B12<br>* Serum HbA1c, Vitamin D, Vitamin B12 values of the patients who applied for gingival treatment in the last 3 months from the date of application were found from the hospital archive and serum was not taken from the patients again for the study.<br>|
| Stage 4 Periodontitis<br>>%33 interdental bone loss with potantial for loss of dentition | Diagnostic Test: HbA1c, Vitamin D, Vitamin B12<br>* Serum HbA1c, Vitamin D, Vitamin B12 values of the patients who applied for gingival treatment in the last 3 months from the date of application were found from the hospital archive and serum was not taken from the patients again for the study.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HbA1c | serum Hemoglobin A1c value | t0:baseline | 
| Vitamin D | serum Vitamin D value | t0 : baseline | 
| Vitamin B12 | serum Vitamin B12 value | t0:baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diabetes Mellitus, Periodontitis, Risk Factors, Vitamin