EXErcise Regimen Designed to Improve Functional Mobility, Body Composition, and Strength After Treatment for Cancer

Study Overview
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Brief Summary
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This protocol seeks to analyze patient outcomes of the standard of care, monitored group exercise regimen of high-load resistance training and functional exercises with compound movements under close supervision on individuals who have been treated for cancer.

Official Title
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EXERT-C: Prospective Study of an EXErcise Regimen Designed to Improve Functional Mobility, Body Composition, and Strength After Treatment for Cancer

Conditions
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Cancer

Intervention / Treatment
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* Other: Dose esclated resistance training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 20-89 years Women of child-bearing potential must verbally confirm lack of pregnancy prior to enrollment. They should also consent to use adequate contraception during the course of the study. Participants must be determined capable of engaging in resistance training by exercise personnel and/or study PI Participants must complete an assessment by EOC staff and be determined safe to engage in the workout regimen by the study exercise personnel. Individuals not deemed safe to participate in the standard EOC exercise program will be referred to physical therapy or elsewhere Exclusion Criteria: 1. Severe arthritic, joint, cardiovascular, or musculoskeletal condition that would interfere with exercise program

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 89 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| General cancer patients<br>All patients undergoing treatment for cancer on an exercise regimen | Other: Dose esclated resistance training<br>* All individuals will be engaging in resistance training during and/or after their cancer treatment<br>|
| Head and neck cancer patients<br>All patients undergoing treatment for head and neck cancer on an exercise regime | Other: Dose esclated resistance training<br>* All individuals will be engaging in resistance training during and/or after their cancer treatment<br>|
| Colorectal cancer patients<br>All patients undergoing treatment for colorectal cancer on an exercise regime | Other: Dose esclated resistance training<br>* All individuals will be engaging in resistance training during and/or after their cancer treatment<br>|
| Pancreatic cancer patients<br>All patients undergoing treatment for pancreatic cancer on an exercise regime | Other: Dose esclated resistance training<br>* All individuals will be engaging in resistance training during and/or after their cancer treatment<br>|
| Metastatic breast cancer patients<br>All patients undergoing treatment for metastatic breast cancer on an exercise regime | Other: Dose esclated resistance training<br>* All individuals will be engaging in resistance training during and/or after their cancer treatment<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine changes in fat mass in pounds from before to after the nutrition and exercise regimen via bioimpedance analysis | Measurement on bioimpedance analysis machine (Inbody 970) | 3 months | 
| Determine changes in fat mass in pounds from before to after the nutrition and exercise regimen via ultrasound | Measurement via ultrasound and calculation with Jackson-Pollack calculations | 3 months | 
| Determine changes in muscle mass in pounds from before to after the nutrition and exercise regimen | Measurement on bioimpedance analysis machine (Inbody 970) | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine changes in overall score of functional movement screen (FMS) from before to after the nutrition and exercise regimen | Determine changes in overall score of functional movement screen (FMS) from before to after the nutrition and exercise regimen | 3 months | 
| Determine changes in Y-balance score for each leg | Y-balance score adds up the distance each leg can move in the front and side directions, divided by the length of the hip. This correlates inversely with fall risk. | 3 months | 
| Determine changes in strength via load measured in pounds from before to after the nutrition and exercise regimen | Load is calculated by multiplying sets by repetitions by weight lifted for a specific exercise | 3 months | 
| Determine changes in EQ-5D responses 1-5 and overall score from before to after the nutrition and exercise regimen | EQ-5D asks 5 questions rates from 1-5 and an overall rating of health | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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exercise, resistance training