Functional Magnetic Resonance-Based Observations of Brain Networks in Moyamoya Disease Patients Under Anesthesia

Study Overview
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Brief Summary
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Moyamoya disease is characterized by progressive stenosis of the genesis of the distal internal carotid arteries bilaterally and progressive generation of compensatory pathological vascular networks at the basis cranii, and these pathological vasculature has poor vascular reactivity. Perioperative circulatory management of patients with smoky vessels to ensure perfusion of brain tissue and integrity of brain network during surgery to minimize postoperative impairment of neurological functions, including motor, sensory, emotional and cognitive functions, is the key point of perioperative circulatory management of moyamoya disease. Functional Magnetic Resonance Imaging (fMRI) has been routinely used in various cerebrovascular diseases to further evaluate cerebrovascular reserve and cerebral network connectivity. The purpose of this study is to observe the changes in cerebral blood flow, cerebral oxygen metabolism, cerebral oxygen metabolism rate, and cerebral network connectivity in adult patients with moyamoya disease in cerebral ischemia-sensitive areas under anesthesia to provide a basis for exploring anesthesia management to improve cognitive function and cerebral network connectivity in these patients.

Official Title
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Functional Magnetic Resonance-Based Observations of Brain Networks and Cerebrovascular Reactivity in Patients With Moyamoya Disease Under Anesthetic Sedation, A Prospective Observational Cohort Study

Conditions
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Moyamoya Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with moyamoya disease scheduled for direct or indirect intracranial and extracranial revascularization surgery Age between 18-65 years Obtain written informed consent. Exclusion Criteria: Patients with preoperative claustrophobia, sensory or motor aphasia that are unable to understand and cooperate with the examination Preoperative cranial imaging suggesting cerebral infarction lesion diameter >15mm Patients allergic to anesthetic drugs Metal implants in the body Undergoing other experimental drug or instrumentation trials

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes of brain functional network |  | Before sedation, after sedation and after maintenan the blood pressure at baseline 100%-120% for 15min | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative delirium |  | Day1-5 after surgery | 
| Electroencephalogram changes |  | Before sedation, after sedation and after maintenan the blood pressure at baseline 100%-120% for 15min | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Moyamoya Disease, Cerebral Network, Cognitive Function, Anesthesia