Diaphragmatic Echography in COVID-19 Pneumonia

Study Overview
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Brief Summary
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We hypothesized that diaphragm thickness is concerned in acute respiratory failure of COVID19 patients and its ultrasound measure at the begining of hospitalisation is a good predictor of poor outcome. A prospective observational non intervention study is designed.

Detailed Description
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To answer our hypothesis we will perform diaphragm ultrasound in the first 24hr hospitalized COVID19 patients. In the ultrasound exploration we will assess diaphragm movility and thickness. We will also assess other clinical, biochemistry and radiological variables. The main outcome we want to analyze is the destination on discharge: home, respiratory intermediate critical unit or exitus.

Official Title
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Prognostic Value of Transthoracic Diaphragmatic Echography in COVID-19 Pneumonia Patients With Acute Respiratory Failure

Conditions
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Pneumonia, Viral, Covid19, Respiratory Failure

Intervention / Treatment
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* Diagnostic Test: Diaphragmatic echography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: COVID19 Pneumonia Acute respiratory failure (PaO2 <60mmHg) Exclusion Criteria: Invasive or non invasive ventilation within first 24h Neuromuscular disease Diaphragmatic paralysis

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Diaphragmatic echography|Diaphragmatic echography|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Early diaphragm ultrasound as a predictor factor for invasive and non invasive ventilation and death | This is the main outcome of our study given that it has a important clinical implications. If we confirm our hypothesis diaphragm ultrasound could prove to be a useful prognosis tool for COVID19 patients. | From date of inclusion until discharge date (lenght of hospitalization) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diaphragm thickness rate as a predictor factor for invasive and non invasive ventilation and death | Diaphragm strenght is directly related to thickness. The impact of COVID19 infection on this specific measure can predict patient evolution. | From date of inclusion until discharge date (lenght of hospitalization) | 
| Diaphragm movility rate as a predictor factor for invasive and non invasive ventilation and death | Diaphragm fatigability is directly related to movility. The impact of COVID19 infection on this specific measure can predict patient evolution. | From date of inclusion until discharge date (lenght of hospitalization) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COVID19 pneumonia, Diaphragm ultrasound