linjc16/ctgov huggingface dataset:
KNOW HOW TO POSITION THE SACCULE AND UTRICULE IN SCANNING

Study Overview
=================
Brief Summary
-----------------
Titanium pistons cause MRI artifacts that prevent interpretation of the vestibule. This disadvantage is not present on CT but the vestibule is not visible. Hence the interest in creating a model with 6 reference cuts in order to position the utricle and the saccule in the vestibule in CT. Furthermore, the scanner has fewer contraindications, greater availability and a shorter examination time than MRI.

Detailed Description
-----------------
The aim of the study is to analyze six normal sections chosen as reference in histology, high resolution T2 MRI and CT in order to compare them with precise topographical landmarks to position the posterior membranous labyrinth in CT. Then, apply the investigators' observations to cases of operated otosclerosis.

Official Title
-----------------
KNOW HOW TO POSITION THE SACCULE AND UTRICULE IN SCANNING: INTEREST IN INTRAVESTIBULAR DISLOCATIONS OF PISTONS OR CALIPER

Conditions
-----------------
Otosclerosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults (≥18 years old) and minors (≥ 6 years old) Subject having received an MRI of the internal ear canals from the HUS between 01/01/2018 and 01/01/2021 or a CT scan of the rocks between 07/01/2015 and 01/01/2021 Normal MRI or CT on the side opposite the pathology. Normal tonal audiogram on the side opposite the pathology (peripheral facial paralysis assumed to be cold for MRI and petrous fracture for CT). Subject who has not expressed his opposition, after information, to the reuse of his data for the purposes of this research. Holders of authority who have not expressed their opposition, after information, to the reuse of their child's data for the purposes of this research Exclusion Criteria: Subject having expressed opposition to participating in the study Holders of parental authority who have expressed their opposition to the reuse of their child's data for the purposes of this research Imaging with artifacts Absence of pure-tone audiogram or its abnormality on the side of the ear studied Any malformation or pathology of the vestibule on imaging on the side of the ear studied Subjects under guardianship or curatorship

Ages Eligible for Study
-----------------
Minimum Age: 6 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence or absence of the anatomical structure referenced in the investigators' reading grid on each of the 6 predefined MRI or CT sections |  | up to 10 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Otosclerosis, Vestibular dysfunction, Membranous Labyrinth
COOL-IT-PRO: Cryoablation of Breast Cancer in Non-surgical Patients

Study Overview
=================
Brief Summary
-----------------
This is a subject registry study of patients who undergo cryoablation for their breast cancer after being determined not to be surgical candidates. Data collected as part of this registry will be used to assess the safety of percutaneous ultrasound-guided cryoablation in this population as well as provide long-term follow-up of subjects who received cryoablation.

Official Title
-----------------
COOL-IT-PRO: Cryoablation of Breast Cancer in Non-surgical Patients: A Prospective Observational Registry

Conditions
-----------------
Breast Cancer, Cancer of the Breast

Intervention / Treatment
-----------------
* Device: Cryoablation


Participation Criteria
=================
Eligibility Criteria
-----------------
Eligibility Criteria: Diagnosis of breast cancer. Mass must be visible on ultrasound and > 5 mm from skin. Not undergoing surgery, because: Patient has a medical condition that would not allow sedation or general anesthesia Surgery is not clinically indicated due to unresectable and/or metastatic disease Surgery is not clinically indicated for another reason Patient declines surgery At least 18 years old. Able to understand and willing to sign an IRB-approved written informed consent document.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cryoablation<br>Following pre-procedural imaging evaluation, patients will receive ultrasound-guided percutaneous cryoablation as part of their routine treatment of their breast cancer. Follow up imaging (if tolerated) will be performed at 6 months and 12 months and annually thereafter for until 3 years post-procedure. Data will be collected on patient demographics, disease characteristics, treatment, treatment complications, follow-up imaging, response (for 3 years post-procedure), and quality of life. | Device: Cryoablation<br>* Takes place at single time point.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of patients who are free of serious treatment related complications per CTCAE v 5.0 |  | Through 3 year follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of patients who demonstrate progression-free survival (PFS) |  | At 3 year follow-up | 
| Proportion of patients who demonstrate disease-free survival (DFS) |  | At 3 year follow-up | 
| Proportion of patients who demonstrate overall survival (OS) |  | At 3 year follow-up |
FoodSEqual Food Study

Study Overview
=================
Brief Summary
-----------------
Diet is an important modifiable risk factor for many chronic diseases, but there is a paucity of dietary data from disadvantaged communities. The last Low Income Diet and Nutrition Survey (LIDNS) was conducted more than a decade ago and disadvantaged communities are known to be under-represented in other national surveys. The aim of the study is to investigate diet and health and factors contributing to dietary choice in a sample of socio-culturally diverse disadvantaged communities using a combination of dietary intake assessment methods, including nutritional biomarkers

Detailed Description
-----------------
The FoodSEqual project is part of a five-year national consortium project led by the University of Reading and involves academics from Plymouth, Sussex, Kent and Cranfield Universities. It is funded by the UK Research and Innovation (UKRI) Strategic Priorities Fund (SPF). The vision of the FoodSEqual project is to provide citizens of socio-culturally diverse disadvantaged communities with choice and agency over the food they consume by co-developing new products, new supply chains and new policy frameworks that deliver affordable, attractive, healthy, and sustainable diet. The FoodSEqual Health project is a follow-on project to investigate associations between diet, health, and food affordability in the context of the FoodSEqual project. Diet is an important modifiable risk factor for many chronic diseases, but there is a paucity of dietary data from disadvantaged communities. The last Low Income Diet and Nutrition Survey (LIDNS) was conducted more than a decade ago and disadvantaged communities are known to be under-represented in other national surveys. The aim of the study is to investigate diet and factors contributing to dietary choice in a sample of socio-culturally diverse disadvantaged communities using a combination of dietary intake assessment methods, including nutritional biomarkers.

Official Title
-----------------
FoodSEqual Food Study

Conditions
-----------------
Diet Habit

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years and over Exclusion Criteria: unable to provide consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Food intake | Habitual dietary intake using biomarkers, FFQ and 24h recall | 18 months |
The Effects of Intra-articular Platelet-Rich Plasma Injection on The Severity of Knee Osteoarthritis

Study Overview
=================
Brief Summary
-----------------
This is a single-center, randomized control trial The aim of this study is to compare PRP with placebo as the treatment of knee OA Conducted at Puri Raharja Hospital Bali in January-June 2022 Sample consisted of 106 patients with knee OA grades 2-3 Kellgren-Lawrence, randomized into PRP group and placebo group Samples were injected with 2 ml PRP or normal saline twice at one-week interval The severity of knee OA was assessed by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) before injection and two weeks after the first injection.

Official Title
-----------------
The Effects of Intra-articular Platelet-Rich Plasma Injection on The Severity of Knee Osteoarthritis

Conditions
-----------------
Osteoarthritis, Knee

Intervention / Treatment
-----------------
* Procedure: PRP
* Other: Normal Saline


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with knee pain for at least three months, aged between 40 to 80 years old, and whose results of radiological examination of the knee indicated OA grades 2-4 based on the Kellgren Lawrence classification Exclusion Criteria: polyarticular rheumatic disease; knee arthroscopy <1 year; intra-articular injection of hyaluronic acid (HA) or steroids in the past three months; current infection, diabetes, rheumatoid arthritis, coagulopathy disorders, anticoagulant or antiplatelet aggregation therapy, immunodeficiency disease, taking non-steroidal anti-inflammatory drugs (NSAIDs) two weeks prior to the procedure, knee trauma; inflammation; and tumors around the knee

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Platelet-rich plasma<br>PRP manufactured by T_Biyoteknoloji LTD, Turkey | Procedure: PRP<br>* 2 ml of platelet rich plasma intraarticular injection twice in one week interval<br>* Other names: T_Biyoteknoloji LTD, Turkey;|
| Placebo Comparator: Normal Saline<br>NaCl 0.9% | Other: Normal Saline<br>* NaCl 0.9%<br>* Other names: NaCl 0.9%;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| WOMAC | The Western Ontario and McMaster Universities Arthritis Index (WOMAC) based on questionnaire | 2 weeks |
Prevalence of Refractive Errors in Primary School Children

Study Overview
=================
Brief Summary
-----------------
The study aim to determine the prevalence of refractive errors in primary school children aged 6-12 in The New Valley , Egypt .

Detailed Description
-----------------
The refractive state of the eye changes as the eye's axial length increases and the cornea and lens flattens. In general, eyes are hyperopic at birth, and become slightly more hyperopic until the age of 7, at this point we see a myopic shift toward Plano until the eyes reach their adult dimensions, usually by about the age of 16.

Official Title
-----------------
Prevalence of Refractive Errors in Primary School Children in The New Valley

Conditions
-----------------
Refractive Errors

Intervention / Treatment
-----------------
* Diagnostic Test: cycloplegic refraction


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age: 6 -12-year-old Myopia :- 0.5 D to -10D Hypermetropia: 1 D to 8 D Astigmatism: 0 to 6 D Distance correction: 0.1 logs MAR (20/25 ) or better Exclusion Criteria: Retinopathy, Prematurity, history of genetic disease, connective tissue diseases (e.g. Stickler or Marfan syndromes, any ocular diseases, Glaucoma, Cataract, Squint.

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: cycloplegic refraction|Cycloplegic autorefraction will be attempted on all children using a table-mounted autorefractor . Cycloplegia will be achieved with three drops of 1% cyclopentolate administered 5 min apart and autorefractive measurements will be performed 30 min after the instillation of the last drop. Auto refraction readings of three consecutive measurements will be obtained and the average will be computed automatically in each eye. Each child will be reexamined until three measurements fell within 0.50 diopters (D) if any two measurements varied by >0.50D.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of refractive error in primary school children | determine the prevalence of refractive error in primary school children aged 6-12 in New Valley, Egypt . | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Degree of Visual aquity improvement of children. | We need to measure : 1-Degree of improvement of visual aquity among those children . 2 - Acceptence of the parents and children to wear spectecles among those population . | Baseline |
Healing Process and Blood Sugar Level Following Local Anesthetic Infiltration With and Without Vasoconstrictor

Study Overview
=================
Brief Summary
-----------------
Evaluating the healing of the extraction socket and the glycemic levels before, and after injection of local anesthesia with and without vasoconstrictor in diabetic patients

Official Title
-----------------
Evaluation of Healing Process and Blood Sugar Level Following Local Anesthetic Infiltration With and Without Vasoconstrictor for Extraction of Maxillary Teeth in Diabetic Patients Double Blind Randomized Clinical Trial

Conditions
-----------------
Diabetes, Anesthesia, Local

Intervention / Treatment
-----------------
* Drug: Local anaesthesia with vasocontrictor (Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Inclusion criteria patients over 20 years and under 60 years of age DM controlled by medication Requiring a tooth extraction in the maxilla, with an indication of the intra-alveolar technique for periodontal reasons. Only participants that are willing to control and record blood glucose level throughout the study period. Exclusion Criteria: Patients with any significant medical condition (besides DM) Alcoholic individuals Patients on drugs that affect the central nervous systems Patients who reported the use of drugs that might interfere with pain sensitivity Pregnant and lactating women Patients with hypersensitivity to local anesthetics or non-steroidal anti-inflammatory drugs (NSAIDs).

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Anaesthesia with vasocontrictor<br> | Drug: Local anaesthesia with vasocontrictor (Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg)<br>* Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg<br>|
| Active Comparator: Anaesthesia without vasocontrictor<br> | Drug: Local anaesthesia with vasocontrictor (Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg)<br>* Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glycemic level recorded before local anesthesia administration and 30 minutes following local anesthesia injection using glucometer |  | 30 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Healing score of the extraction socket |  | 21 days |
FES VS Constrained Induced MT Recovery and Spasticity in Upper Limb Hemiparetic Ischemic Patients

Study Overview
=================
Brief Summary
-----------------
To determines the effects of Functional Electrical Stimulation versus Constrained Induced Movement Therapy for motor recovery and spasticity in Upper Limb Hemiparetic Chronic Ischemic Stroke Patients

Official Title
-----------------
Functional Electrical Stimulation Versus Constrained Induced Movement Therapy for Motor Recovery and Spasticity in Upper Limb Hemiparetic Chronic Ischemic Stroke Patients

Conditions
-----------------
Stroke

Intervention / Treatment
-----------------
* Diagnostic Test: Functional Electrical Stimulation
* Diagnostic Test: Constrained Induced Movement Therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinically diagnosed chronic ischemic stroke patients. Patients from both genders Age 45 year and older. Patients having upper limb spasticity equal to 2 or less than 2 according to modified ash worth scale. Patients having active cognitive scoring on Mini Mental State Examination. Exclusion Criteria: Having pacemaker and other stimulation devices. Prosthesis of bones, joints in targeted region of treatment. Patients presenting the history of recurrent stroke. Patients having history of bilateral hemiparesis. Co-morbid history of tumor, heart disease, hypertensive. Patients presenting with skin lesions, wounds, discoloration will be excluded from this research.

Ages Eligible for Study
-----------------
Minimum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Functional Electrical Stimulation<br> | Diagnostic Test: Functional Electrical Stimulation<br>* Functional Electrical Stimulation for Motor Recovery and Spasticity in Upper Limb Hemiparetic Chronic Ischemic Stroke Patients<br>|
| Experimental: Constrained Induced Movement Therapy<br> | Diagnostic Test: Constrained Induced Movement Therapy<br>* Constrained Induced Movement Therapy for Motor Recovery and Spasticity in Upper Limb Hemiparetic Chronic Ischemic Stroke Patients<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Scale Modified Ash worth |  | 6 Months | 
| Motor Function assessment test |  | 6 Months |
Carpal Tunnel Release With Risk Factors for Amyloidosis

Study Overview
=================
Brief Summary
-----------------
Bilateral carpal tunnel syndrome has been demonstrated in previous literature to be a warning sign for potential amyloidosis. One study has been performed in which patients with bilateral carpal tunnel syndrome underwent tissue biopsy (either tendon sheath or transverse carpal ligament) at the time of carpal tunnel release to determine the strength of association as well as most common subtypes. However, no study has been done demonstrating whether or not patients with amyloid-positive carpal tunnel biopsy would benefit from an early referral to cardiology for a work-up of potential cardiac amyloidosis. In our study, patients with bilateral carpal tunnel symptoms who are indicated for carpal tunnel release would be identified in clinic and undergo biopsy for congo red staining at the time of surgery. All patients with positive biopsy results would be referred to cardiology. Outcomes would include the rate of amyloid positivity, common subtypes, and echocardiographic findings after cardiac referral.

Official Title
-----------------
Prospective Histopathologic and Clinical Evaluation of Patients Undergoing Carpal Tunnel Release With Risk Markers for Amyloidosis

Conditions
-----------------
Amyloidosis

Intervention / Treatment
-----------------
* Procedure: Carpal Tunnel Release Surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Positive screening is defined as two characteristics from Tier 1 or one characteristic from Tier 1 and one from Tier 2 Tier 1 Male > 50 years old Female > 60 years old Bilateral carpal tunnel symptoms or prior release surgery Tier 2 Spinal stenosis History of biceps tendon rupture Atrial fibrillation or flutter (active or previous history) Pacemaker Congestive heart failure Family history of transthyretin amyloidosis (ATTR) Exclusion Criteria: Unable or unwilling to follow up with cardiology. Previous diagnosis of cardiac amyloidosis.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Carpal Tunnel Release<br> | Procedure: Carpal Tunnel Release Surgery<br>* Carpal tunnel release surgery used to take a biopsy to diagnose amyloidosis and determine whether or not carpal tunnel syndrome can predict who's at risk for having amyloidosis.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of amyloid positivity | How many patients who participate in study have positive biopsy for amyloidosis. | Biopsy sent for testing immediately after the procedure |