A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to compare the effects of Krill Oil and Fish Oil supplementation on muscle function in older adults. The secondary aim is to investigate the mechanisms underlying the beneficial effects previously observed.

Official Title
-----------------
A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults: a Randomised Controlled Pilot Study

Conditions
-----------------
Sarcopenia

Intervention / Treatment
-----------------
* Dietary Supplement: Fish oil
* Dietary Supplement: Kril oil
* Dietary Supplement: Vegetable oil


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Older adults (aged 60 years or older). BMI less than 30kg/m2 Exclusion Criteria: Participants (diagnosed and being treated for a pre-existing medical condition (cancer, kidney disease, liver disease, diabetes mellitus and cardiovascular disease, uncontrolled hypertension, gait disturbances limiting the ability to perform assessments of muscle function, dementia, affecting muscles known to use drugs (e.g., steroids). History of allergy to fish or fish oil and regular consumption of more than1portion of oily fish per week or use of fish oil or krill oil supplements will also be excluded.

Ages Eligible for Study
-----------------
Minimum Age: 60 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: 1:1:1 basis
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Fish oil<br>Fish oil 4 g/day | Dietary Supplement: Fish oil<br>* EPA rich fish oil<br>|
| Active Comparator: Krill oil<br>Krill oil 4g/day | Dietary Supplement: Kril oil<br>* Superba Krill Oil<br>|
| Placebo Comparator: Placebo<br>Vegetable oil 4g/day | Dietary Supplement: Vegetable oil<br>* Mixed vegetable oil<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in knee extensor maximal isometric torque ( MVC) | Knee extensor maximal isometric torque measured during a maximal voluntary contraction | Change from baseline to 16 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in fat mass | Whole body fat mass measured by measured via bio-electrical impedance | Change from baseline to 16 weeks | 
| Change in lean mass | Whole body lean mass measured by measured via bio-electrical impedance | Change from baseline to 16 weeks | 
| Blood sample | Red Blood Cell Omega-3 levels | Change from baseline to 16 weeks | 
| Change in Grip strength | Grip strength measured with a hand held dynamometer | Change from baseline to 16 weeks | 
| Change in Muscle thickness | Vastus lateralis muscle thickness measured by ultrasound | Change from baseline to 16 weeks | 
| Force steadiness during submaximal isometric knee extensor contractions | Measured by using intramuscular iEMG | Change from baseline to 16 weeks | 
| Neuromuscular Junction (NMJ) | Measured by iEMG | Change from baseline to 16 weeks | 
| Change in gait speed | Time taken to walk 4 metres at a normal walking pace | Change from baseline to 16 weeks | 
| Change in Chair rise time | A 30-second sit-to-stand test measured functional abilities | Change from baseline to 16 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
muscle mass, strength, omega-3, ageing