Effect of Adding Zirconium Oxide Nanoparticles to Printable Implant Overdenture

Study Overview
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Brief Summary
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This clinical study will be conducted to evaluate and compare non-modified printable acrylic resin base material and modified printable acrylic resin base material with zirconia oxide nanoparticles for a 2-implant retained complete overdenture regarding:Surface roughness; microbiological assessment of denture base microbiological analysis peri-implant soft tissue health around used implants

Official Title
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Effect of Adding Zirconium Oxide Nanoparticles to Printable Implant Overdenture Acrylic Resin Base Material. Clinical Comparative Study

Conditions
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Prosthesis Durability

Intervention / Treatment
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* Procedure: implant supported overdenture


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1. Patients are healthy, free from any systemic diseases relating to bone resorption such as uncontrolled diabetics or osteoporosis. This will be achieved through medical history and clinical examination by physician. 2. They will have completely edentulous jaws for at least 1 year. 3. They will be of angle's class I maxillo-mandibular relationship and have upper and lower completely edentulous arches. 4. Residual alveolar ridges covered with healthy firm mucosa. 5. All included patients will have sufficient available length and width of mandibular bone to accommodate conventional implant. (At least 5 mm buccolingual width and 12 mm vertical height of bone. Exclusion Criteria: Patients with chronic systemic diseases that affect bone metabolism Uncontrolled diabetic patients Patients with TMJ dysfunction Smokers

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group (I) non modified<br>Five patients will receive mandibular 2-implant retained overdentures of non-modified printable acrylic resin base material. | Procedure: implant supported overdenture<br>* mandibular 2-implant retained overdenture of non-modified printable acrylate resins base material with Zirconium oxide nanoparticles<br>|
| Active Comparator: Group (II) modified<br>Five patients will receive mandibular 2-implant retained overdentures of modified printable acrylate resin base material with zirconium oxide nanoparticles. | Procedure: implant supported overdenture<br>* mandibular 2-implant retained overdenture of non-modified printable acrylate resins base material with Zirconium oxide nanoparticles<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Surface roughness | Surface roughness: will be evaluated using profilometer device | one year | 
| Microbiological assessment | Microbiological assessment of denture base surface microbiological analysis | one year | 
| Peri-implant soft tissue health | was evaluated using scores for plaque and gingival bleeding | one year |