linjc16/ctgov huggingface dataset:
Bedside Renal Ultrasound Assessment in Patients With Acute Kidney Injury

Study Overview
=================
Brief Summary
-----------------
Exploring the predictive and evaluative value of various indicators of bedside critical renal ultrasound in critically ill patients with acute kidney injury (AKI)

Detailed Description
-----------------
This study aims to perform bedside renal ultrasound examinations on critically ill patients admitted to the ICU (including sepsis, respiratory failure, shock, multiple trauma, etc.) and prospectively observe the relationship between ultrasound parameters and the occurrence and progression of AKI, in conjunction with traditional renal function indicators. This will provide clinicians with a rapid, non-invasive, and visual examination tool at the bedside for early diagnosis and treatment of AKI.

Official Title
-----------------
Bedside Renal Ultrasound Assessment in Critically Ill Patients With Acute Kidney Injury: an Observational Study

Conditions
-----------------
Critical Illness

Intervention / Treatment
-----------------
* Other: No Intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥ 18 years and ≤ 70 years Criteria for sepsis patients Exclusion Criteria: Pregnant women. Patients with malignant tumors, severe heart failure, chronic renal insufficiency, end stage renal disease, kidney transplantation.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: No Intervention|No Intervention|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival | 28-day mortality rate | 28 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| AKI | duration of continuous renal replacement therapy (CRRT)during hospitalization, length of hospital stay, duration of ICU stay, hospital mortality rate, 28-day mortality rate, and other relevant data. | 28 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Critical Illness, Ultrasound Therapy, Kidney injury
MRI-based Artificial Intelligence Software (NNS-SOT) for Onset Time Estimation in Lesion With Acute Ischemic Stroke

Study Overview
=================
Brief Summary
-----------------
This study evaluates the efficacy of investigational device named Stroke Onset Time Artificial Intelligence(AI) (Model name:NNS-SOT). Using the investigational device, analyze the image and the onset time of occurrence of acute ischemic stroke lesion on the brain image (4.5 hours or more from the onset of symptoms) and evaluate the efficacy of correctly estimating the onset time.

Detailed Description
-----------------
This clinical trial software medical device (Model name: NNS-SOT) is developed based on artificial intelligence algorithms. Through clinical validation, it will be easier to determine whether the golden hour (4.5 hours) has elapsed at the time of cerebral infarction in the medical field. It can be used for estimation of the onset time of occurrence in acute ischemic stroke.

Official Title
-----------------
Evaluating the Validation of MRI-based Artificial Intelligence Software (NNS-SOT) for Onset Time Estimation in Lesion With Acute Ischemic Stroke : a Single-center, Single-arm, Single-blind (Evaluator), Retrospective Pivotal Trial

Conditions
-----------------
Acute Ischemic Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Brain imaging in patients with acute ischemic stroke aged 20 years and older Brain imaging of ischemic stroke manifestation lesion confirmed by medical staff in brain MR image Brain imaging taken within 24 hours of ischemic stroke symptoms Brain imaging including Magnetic Resonance(MR) images (DWI and FLAIR) Patients with clearly recorded onset time of acute ischemic stroke symptoms Exclusion Criteria: Brain imaging used in NNS-SOT development process Brain imaging with noise (Artifact) Brain images damaged in data

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivity and specificity | Evaluation of sensitivity and specificity of clinical performance (estimation of 4.5 hours or more after cerebral infarction) performed with clinical trial medical device | October - November 2023 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Area Under the Curve(AUC), which is the lower area of the Receiver Operating Characteristics(ROC) curve | Lower limit of 95% confidence interval is 80% or more | October - November 2023 |
Efficacy and Safety of DKM420 in Patients With Osteoarthritis of Knee

Study Overview
=================
Brief Summary
-----------------
To prove the non-inferiority of DKM420 by evaluating the injecting efficacy and safety DKM 420 and control for patients who have osteoarthritis of Knee.

Detailed Description
-----------------
A multi-center, randomized, double-blind, active-controlled, pivotal, non-inferiority clinical study

Official Title
-----------------
A Multi-center, Randomized, Double-blind, Active-controlled, Pivotal, Non-inferiority Clinical Study to Evaluate the Efficacy and Safety of 'DKM420' in Knee Osteoarthritis Patients.

Conditions
-----------------
Osteoarthritis of Knee

Intervention / Treatment
-----------------
* Device: DKM420
* Device: Conjuran


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Men and Women who is over 40 under 80 ages. Diagnosed as osteoarthritis of Knee and satisfies the 3 of 6 ACR(American College of Rheumatology) conditions. Kellgren Lawrence grade (Ⅰ Ⅲ) at Visit 1 or within 24 weeks. 100mm VAS(Visual Analogue Scale) over 40mm. Etc. Exclusion Criteria: - Pregnancy and lactating women

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: 1:1 Parallel.
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: DKM420<br>Injecting to one side knee. | Device: DKM420<br>* A total of 3 doses will be applied at a dose of 2 mL over 3 weeks.<br>|
| Active Comparator: Conjuran<br>Injecting to one side knee. | Device: Conjuran<br>* A total of 3 doses will be applied at a dose of 2 mL over 3 weeks.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 100mm VAS(Visual Analogue Scale) | Change(The minimum value is 0mm, the maximum value is 100m, the lower the better.) | 16 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 100mm VAS(Visual Analogue Scale) | Change(The minimum value is 0mm, the maximum value is 100m, the lower the better.) | 2, 8 weeks | 
| K-WOMAC(Korean Western Ontario and McMaster Universities) | Change(Score from 0 to 96, the lower the better.) | 2, 8, 16 weeks |
CT Image-assisted Detection Software for Focal Liver Lesions

Study Overview
=================
Brief Summary
-----------------
To evaluate the safety and effectiveness of the developed and produced CT image-assisted detection software for focal liver lesions before being put into the market.

Official Title
-----------------
A Retrospective, Multicenter, Multiple-viewer-multiple-case (MRMC) Clinical Trial to Evaluate the Safety and Efficacy of CT Image-assisted Detection Software for Focal Liver Lesions

Conditions
-----------------
Focal Liver Lesion

Intervention / Treatment
-----------------
* Device: CT image-assisted detection software


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: doctors have liver CT scanning experience more than 1 year; Exclusion Criteria: persons don't have the license of practicing physician; doctors don't have liver CT scanning experience or have liver CT scanning experience less than 1 year;

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: AI-assisted diagnosis<br>Doctors diagnose the focal liver lesion with the help of AI. | Device: CT image-assisted detection software<br>* CT image-assisted detection software can help doctor to diagnosis the focal liver lesion<br>|
| No Intervention: common diagnosis<br>Doctors diagnose the focal liver lesion without the help of AI. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| AFROC | Under different confidence scores, the number of accurately located lesions/the number of true lesions determined by the reference standard was taken as the ordinate coordinate, and (1- the number of negative cases determined by the reference standard/the total number of true negative cases diagnosed by the reference standard) was plotted as the horizontal coordinate | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
CT image-assisted detection software, focal liver lesion
Trends of Vitreoretinal Surgery in Children

Study Overview
=================
Brief Summary
-----------------
Purpose: We determined the incidence, etiology, and longitudinal trends of vitreoretinal diseases necessitating pars plana vitrectomy (PPV) in the pediatric and adolescent population. Design: This was a nationwide, population-based cohort study, utilizing data from the Korean National Health Claims database spanning from 2009 to 2020. Given the retrospective design of the study and the anonymized nature of the data, the requirement for informed consent was waived. Methods: All pediatric and adolescent patients (under 20 years of age) who underwent PPV across the Korean population were included. The cumulative incidence of PPV was estimated from 2009 to 2020, with 2009 to 2011 as the washout period. The annual trends of PPV incidence, the proportion of each etiology, and comorbidity were estimated based on sex and specific age groups.

Official Title
-----------------
Contemporary Patterns and Underlying Causes of Vitrectomy in Pediatric and Adolescent Patients: A Nationwide, Population-Based Analysis

Conditions
-----------------
Vitreoretinal Disease

Intervention / Treatment
-----------------
* Other: no intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: We included all pediatric and adolescent patients who underwent complete PPV (registered under code S5121) during the study period from January 2009 to December 2020, and who were continuously enrolled in a medical plan, in our estimates.

Ages Eligible for Study
-----------------
Minimum Age: 0 Years
Maximum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: no intervention|no intervention, just retrospective observation|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of vitreoretinal surgery | vitreoretinal surgeries that had already performed during the retrospective study period | 2009-2020 |
Results of Unicompartmental Knee Arthroplasties in Patients Beyond Historical Indications (PUCIL)

Study Overview
=================
Brief Summary
-----------------
Primary objective: To compare medial uni compartimental knee arthroplasty between patients who had a limit factor prior to the surgery ans patients who fill thé historical criteria. Secondary objectives 1 to compare survival of medial UKA between patients with one limit factor and those with multiple limits. 2. To identify the prognosis factors of failure in medial UKA in our center during the time of our analysis (2009-2015)

Detailed Description
-----------------
7 year follow up survival if no amputation or no removal of UKA for TKA

Official Title
-----------------
Unicompartimental Knee Arthroplasties When Borders Are Crossed : Survival Study at 7 Years

Conditions
-----------------
Knee Disease

Intervention / Treatment
-----------------
* Procedure: Unicompartmental knee arthroplasty


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - medial UKA implanted between 2009 and 2015 at the CCEG Exclusion Criteria: no other UKA lost to follow up patient refuses

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Limit indications<br>Obèse (BMI>30), ACL déficiency, HKA > 10°, flessum >10° [HKA : hop knee angle] | Procedure: Unicompartmental knee arthroplasty<br>* medial unicompartmental knee arthroplasty<br>|
| Historical indications<br>Patient with a BMI between 18,5 and 30, HKA <10°, functionnal ACL, no flessum or <5° | Procedure: Unicompartmental knee arthroplasty<br>* medial unicompartmental knee arthroplasty<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival of medial UKA | UKA changed or replaced by TKA | 7 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| to compare UKA survival if multiple limit indication | UKA changed or replaced by TKA | 7 years | 
| to identify prognostic factors of re operation of patients with a medial UKA implanted between 2009 and 2015 at the CCEG | ACL, flessum, HKA, weight | 7 years |
EFFECT OF CHEWING GUM ON CONTROLLING NAUSEA/VOMITING AND THIRST IN PATIENTS WITH ACUTE PANCREATITIS

Study Overview
=================
Brief Summary
-----------------
Nausea and vomiting are one of the most common symptoms in acute pancreatitis. In addition to pharmacological methods for nausea and vomiting, non-pharmacological methods can also be used. Among these, anticipatory nausea and vomiting can be prevented by behaviors aimed at distracting attention. This study will be conducted to evaluate the effect of chewing gum on the severity of nausea-vomiting and thirst in patients with acute pancreatitis. The study will be conducted with a total of 60 patients, 30 intervention and 30 control. Patients in the intervention group will chew xylitol gum five times a day for three days. The patients' thirst and nausea and vomiting conditions will be examined.

Official Title
-----------------
Erciyes University

Conditions
-----------------
Acute Pancreatitis, Thirst

Intervention / Treatment
-----------------
* Other: Gum group


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Those diagnosed with acute pancreatitis, Without total dental prosthesis, Without salivary gland infection, Those who have not had salivary gland surgery, No difficulty in chewing, Not receiving oxygen therapy, Able to answer all questions and be communicativ Exclusion Criteria: Those with diabetes, Does not like chewing gum, Receiving radiotherapy or chemotherapy,

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: intervention group<br> | Other: Gum group<br>* Group chewing gum with xylitol<br>|
| No Intervention: Control group<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Thirst Severity -Visual Analog Scale | Visual Analog Scale is a 10 cm long scale that evaluates the severity of thirst. | Apply in the morning of the 1st day after application | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rhodes Nausea, Vomiting and Retching Index | It is an eight-item scale that measures the number and severity of patients' nausea, vomiting and retching in the last 24 hours. | Apply in the morning of the 1st day after application | 
| Rhodes Nausea, Vomiting and Retching Index ( | It is an eight-item scale that measures the number and severity of patients' nausea, vomiting and retching in the last 24 hours. | Apply in the morning of the 1st day after application | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Acute Pancreatitis, Thirst, nouse, vomiting
Vastus Medialis Activation During McMurray's Test

Study Overview
=================
Brief Summary
-----------------
This study will use electromyography to evaluate activation patterns of the vastus medialis and vastus lateralis muscles during the McMurray's knee examination test in different knee positions.

Detailed Description
-----------------
The McMurray test is commonly used to assess knee pathology. However, it is unclear which knee position during this test best isolates activity of the vastus medialis muscle. This study will measure vastus medialis and lateralis activation using surface electromyography in 30 healthy participants performing the McMurray test. Different knee flexion and rotation angles will be evaluated to determine which position optimally activates the vastus medialis. Results may enhance utilization of the McMurray test in rehabilitation programs targeting this muscle.

Official Title
-----------------
Muscle Activation Patterns During the McMurray's Test for Knee Examination

Conditions
-----------------
Electromyography, Knee Injuries, Knee Pain Chronic

Intervention / Treatment
-----------------
* Diagnostic Test: McMurray knee examination test


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy adults aged 18-45 years No history of knee pathology Exclusion Criteria: Contraindications to EMG Neurological or muscular disorders

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Adults<br>30 healthy adult participants aged 18-45 years performing the McMurray knee examination test | Diagnostic Test: McMurray knee examination test<br>* The McMurray test will be performed in different knee flexion and rotation angles.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vastus Medialis Activation | Mean EMG activity of the vastus medialis during McMurray test at different knee positions. Measured in microvolts (μV). | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vastus lateralis EMG activity during McMurray test (μV) | Mean EMG activity of the vastus lateralis muscle during the McMurray knee examination test at different knee flexion and rotation angles. Measured in microvolts (μV). | baseline | 
| Force exerted during McMurray test measured by dynamometer (Newtons) | Maximum voluntary isometric knee extension force measured using a handheld dynamometer during the McMurray knee examination test at different knee positions. Measured in Newtons (N). | baseline |
Outcome Predictors of Trachea-esophageal Fistula

Study Overview
=================
Brief Summary
-----------------
In the present study, the investigator aim to evaluate the prevalence, factors affecting outcome and the outcome of neonates with tracheoesophageal fistula.

Detailed Description
-----------------
Tracheoesophageal fistula is a connection between the esophagus and the trachea. Tracheoesophageal fistula (TEF) represents one of the most common congenital anomalies seen in infants, Infants with TEF classically present with respiratory distress, feeding difficulties, choking, and risk for aspiration. TEF is most commonly associated with other congenital anomalies, particularly cardiac defects. Esophageal atresia (EA) is a related congenital malformation with a similar presentation to TEF and can occur with or without the presence of a fistula. Although the events leading to separation of the primitive trachea and esophagus are not completely understood, the most commonly accepted hypothesis is that a defect in the lateral septation of the foregut into the trachea and esophagus causes TEF and EA. The trachea and esophagus develop from a common primitive foregut, and at approximately 4 weeks of gestation, the developing respiratory and gastrointestinal tracts are separated by epithelial ridges. The foregut divides into a ventral respiratory tract and a dorsal esophageal tract; the fistula tract is thought to derive from an embryonic lung bud that fails to undergo branching. These defects of mesenchymal proliferation are thought to lead to TEF formation. The incidence of TEF is approximately 1 in 3500 births. EA and TEF are classified according to their anatomic configuration.

Official Title
-----------------
Outcome Predictors of Trachea-esophageal Fistula in Neonates Admitted to AUCH

Conditions
-----------------
Tracheo Esophageal Fistula

Intervention / Treatment
-----------------
* Procedure: Tracheoesophageal fistula repair


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients diagnosed with tracheoesophageal fistula are/below the age of 28 days. Exclusion Criteria: Patients above the age of 28 days. Patients diagnosed with other diseases. Patients with acquired tracheoesophageal fistula.

Ages Eligible for Study
-----------------
Maximum Age: 28 Days

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Tracheoesophageal fistula repair|Tracheoesophageal fistula repair|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Affection of tracheo-esophageal fistula in neanates | evaluate factors affecting outcome of neonates with tracheoesophageal fistula. | Baseline |