Empiric Antibiotic Treatment for Septic Patients in the Intensive Care Unit

Study Overview
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Brief Summary
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Sepsis is one of the most common causes of ICU admission. About 5-15% of patients admitted to the hospital with an infection will have sepsis, and about 30-40% of them will have septic shock. About 34% of septic patients and about 53% of patients with septic shock will die within 28 days of admission. Broad-spectrum empiric antibiotic treatment (depending on the source of infection and patient risk factors) is one of the cornerstones of sepsis management. According to the recommendations of the surviving sepsis campaign, empiric antibiotic treatment should be given within one hour of the patient's arrival for patients with sepsis or septic shock. Administration of inappropriate antibiotics in the first 24 hours of admission was found in 34% of septic patients in various studies, and administration of inappropriate antibiotics (or when administered in delay) was found to be associated with increased morbidity and mortality. In this study, we will assess the proportion of patients who were admitted to the ICU due to sepsis or septic shock and received empiric antibiotic treatment which, in retrospect, according to the growth in the cultures later on, was inappropriate. We will also assess the therapeutic results in these patients - mainly significant morbidity and mortality within 28 days, and compare them to the group of patients who received appropriate antibiotic therapy. We would also like to assess what were the possible reasons for inappropriate empiric antibiotic treatment, in order to draw conclusions to reduce the rate of these cases.

Official Title
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Empiric Antibiotic Treatment for Septic Patients in the Intensive Care Unit: Appropriateness and Therapeutic Outcomes

Conditions
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Septic Patients Admitted to the ICU

Intervention / Treatment
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* Other: empiric antibiotic therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients admitted to the general ICU due to sepsis or septic shock between 1/1/20 and 31/12/20 Exclusion Criteria: Patients who were admitted due to other non-infectious etiologies -

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| septic patients who recieved appropriate empiric antibiotics<br> | Other: empiric antibiotic therapy<br>* septic ICU patient given broad spectrum antibiotic therapy<br>|
| septic patients who recieved inappropriate empiric antibiotics<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of septic patients who recieved inappropriate empiric antibiotic therapy | Proportion of septic patients who recieved inappropriate empiric antibiotic therapy | January 2020-December 2020 |