Effects of Platelet-Rich Fibrin in Patients With Anterior Cruciate Ligament Reconstruction

Study Overview
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Brief Summary
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The study was conducted to investigate the effects of platelet-rich fibrin on knee stability, knee muscle strength and knee function in patients with ACL reconstruction. Thirty patients with ACL reconstruction were included to the study and randomly divided into two groups. Patients were assessed preoperative and at the postoperative 1-year.

Detailed Description
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The study was conducted yo investigate the effects of platelet-rich fibrin (PRF) on the knee stability and function in patients with anterior cruciate ligament (ACL) reconstruction. Thirty patients with ACL reconstruction were included to the study and randomly divided into two groups (PRF group and control group). Hamstring tendon autograft was used in all patients for the reconstruction of the teared ACL. A standardized postoperative rehabilitation program was applied to all patients. Patients' knee stability, knee muscle strength and knee function were assessed preoperatively and one-year postoperatively. Knee stability was assessed using KT-2000 Knee Arthrometer. Quadriceps femoris and hamstring muscle strength measurements were conducted with an isokinetic dynamometer at 60˚/sec and 180˚/sec angular velocities. One Leg Hop (OLH) and Y-Balance tests, and International Knee Documentation Committee (IKDC) were used to evaluate the knee function.

Official Title
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Effects of Platelet-Rich Fibrin on Knee Muscle Strength and Function in Patients With Anterior Cruciate Ligament Reconstruction

Conditions
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Effects of Platelet-Rich Fibrin on Knee Stability and Knee Function

Intervention / Treatment
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* Biological: Platelet-Rich Fibrin during Standard ACL reconstruction surgery
* Other: Standard ACL reconstruction surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being isolated ACL reconstruction, Being between the ages of 18-45 years, Performing sports recreationally or professionally Exclusion Criteria: Having previous knee surgery, Having systematic disease, Having multiple ligament injury on the knee or additional cartilage injuries

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Randomised controlled design
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: PRF Group<br>Patients in this group, received PRF application during the standard ACL reconstruction surgery | Biological: Platelet-Rich Fibrin during Standard ACL reconstruction surgery<br>* Plateleth-rich fibrin was obtained from patients own blood (40 cc) and applied to the tunnels which were drilled for ACL graft<br>|
| Active Comparator: Control Group<br>Patients in this group received a standard ACL reconstruction surgery without any other intervention. | Other: Standard ACL reconstruction surgery<br>* This was a control group where patients received Standard ACL reconstruction surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in the Knee Laxity | Knee laxity was measured using Kneelax-3 Knee arthrometer | Preoperatively ans one year postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in the Knee Muscle Strenght | Qudriceps and hamstring muscle strength were measured using an isokinetic dynamometer | Preoperatively ans one year postoperatively | 
| Changes in the Knee Function | Knee function was assessed with one leg hop (OLH) test and Y-Balance tests | Preoperatively and one year postoperatively | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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return to play, Anterior cruciate ligament, platelet-rich fibrin