The Efficacy of Autogenous Dentin Graft in Mandibular Wisdom Tooth Extraction

Study Overview
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Brief Summary
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The study aimed to investigate clinical effect of autogenous dentin graft on patients following mandibular wisdom tooth extraction. The primary outcomes are pain, swelling, trismus and soft tissue healing index within one week after surgery. The investigators also measured periodontal healing of distal aspect of the adjacent second molar up to 2 year after the surgery.

Official Title
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The Clinical Effect of Autogenous Dentin Graft in Mandibular Third Molar Surgery

Conditions
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Periodontal Pocket, Swelling Lips & Face, Trismus, Pain, Acute

Intervention / Treatment
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* Procedure: Autogenous dentin graft


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Over 18 years old Symmetry mandibular third molars Symmetry maxillary third molars with no caries or periodontal disease Mandibular second molars are available Exclusion Criteria: Systematic health has contraindication for surgery Pregnant or breastfeeding women Allergy with Lidocaine Abnormal signs surrounding mandibular third molars

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Dentin graft<br> | Procedure: Autogenous dentin graft<br>* Dentin graft is made from the participant extracted tooth by using Kometa Smart Dentin Grinder<br>|
| No Intervention: Conventional<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of self-reported pain | Pain is measured by self-reported Likert scale from 0 to 5. Higher score indicated more painful situation. Result is reported by the mean score. | 3 days, 7 days | 
| Self-reported swelling | Patients reported their perception about swelling levels. There are 6 levels of this scale, score from 0 to 5. Higher score means more swelling. | 3 days, 7 days | 
| Trismus | Trismus is measured by difference of maximal mouth opening between post-and pre-operative wisdom tooth surgery. Maximal mouth opening is mueasured by distance of mesial incisal edge of maxillary and mandibular central incisor. | 3 days, 7 days | 
| Soft tissue healing score | The soft tissue healing score is evaluated according to Hamzami (2018). It includes 8 sub-items. Each item is recorded as 0 or 1 (score). Then, total score of the first 30 days (3 evaluation time) is used to classify wound healing level (good, acceptable, and bad). | 3 days, 7 days, 30 days | 
| Aveolar height | Aveolar height is measured as the distance from cementoenamel joint on distal surface of second molar to the aveolar ridge. The landmark points are defined on periapical film. The aveolar height is measured at 7 days, 3 months, 6 months and 2 years after the surgery. | 7 days, 2 months, 6 months, 2 years | 
| Swelling measured by facial dimension | Difference of distances of facial landmark points between post-and pre-operative wisdom tooth surgery. Two distances (AB and CD) from 4 landmark points are used for measurement: A - lateral commissure of the eye, B - gonion, C - tragus, and D - lateral commissure of the lips. | 3 days, 7 days |