Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis

Study Overview
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Brief Summary
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To evaluate the safety and effectiveness of PRP injection therapy in the repair of osteoarthritis and periarticular soft tissue injury through a single-center, exploratory clinical study, and to provide a more reliable basis for the treatment of joint injury.

Official Title
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Therapeutic Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis and Periarticular Tissue Injury

Conditions
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Platelets-rich Plasma, Osteoarthritis Knees Both, Meniscus Disorder, Cartilage Injury

Intervention / Treatment
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* Drug: Sodium hyaluronate injection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The age range of the participants was 20 to 60 years old. Through a comprehensive clinical and imaging examination, it was conclusively determined that the individuals had knee osteoarthritis or experienced injuries to the cart, and meniscus surrounding the knee joint. The preoperative routine tests and examinations revealed no contraindications. Revised sentence: Informed consent of the patient Exclusion Criteria: The platelet count or function exhibits significant abnormalities、Systemic infection transmitted through the bloodstream. Prolonged usage of anti-inflammatory drugs and systemic corticoid administration. In injection site or damage to the skin. Patients with tumors or undergoing radiotherapy and chemotherapy. Pregnant or breastfeeding women. Individuals with mental illnesses who are unable to cooperate with follow-up procedures. Contraindications for MRI、Patients or their families do consent to participate in the study. Other circumstances that render participation in the study unsuitable.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Preoperative<br> | |
| Experimental: postoperative (6 weeks)<br>The patients were injected with PRP. | Drug: Sodium hyaluronate injection<br>* The control group was injected into the joint cavity with sodium hyaluronate injection..<br>|
| Experimental: postoperative (3 months)<br>The patients were injected with PRP. | Drug: Sodium hyaluronate injection<br>* The control group was injected into the joint cavity with sodium hyaluronate injection..<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| X-ray | The postoperative plain X-ray film was utilized for the assessment of knee joint deformity, stenosis of the joint space, and hyperplasia of osteophytes. | pre-operation,3 weeks after treatment, 6 months after treatment | 
| CT | The application of three-dimensional CT scan for the assessment of articular cartilage defects. | pre-operation,3 weeks after treatment, 6 months after treatment | 
| MRI | The injury of ligaments, meniscus, and the knee joint was assessed using MRI. | pre-operation,3 weeks after treatment, 6 months after treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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platelets-rich plasma, Osteoarthritis, Cartilage Injury, Meniscus Injury