Role of Endocrine Disruptors in Thyroid Cancer

Study Overview
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Brief Summary
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the relationship between human exposure to EDCS and TC is poorly investigated and still unclear. The aim of this study is to evaluate the possible role of old and new generation endocrine disruptors in thyroid cancer. The primary aim is to evaluate the difference in the average levels of the main endocrine disruptors (PFAS, including: PFOA, PFOS, PFDA, PFUnA, PFHpS and possibly subsequently other categories, such as bisphenols, phthalates, parabens, PCBs, flame retardants) between patients with and without a diagnosis of thyroid cancer through highly sensitive, selective and precise mass spectrometry methods, such as liquid chromatography combined with tandem mass spectrometry (LC-MS / MS). The secondary aim is to evaluate the relationship between the concentrations of endocrine disruptors and some anamnestic variables studied (for example the type of diet, the use of personal care products).

Official Title
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Cross-sectional Case-control Study on the Role of Endocrine Disruptors in Thyroid Cancer

Conditions
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Endocrine Disruptor Chemicals, Thyroid Cancer

Intervention / Treatment
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* Diagnostic Test: Blood and urine diagnostic evaluation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with a diagnosis of thyroid cancer in the last 5 years (arm A) patients without a diagnosis of thyroid cancer will match patients included in arm A Exclusion Criteria: subjects under 18 years old patients unable to sign the informed consent or questionnaires

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Case group<br>Patients with thyroid cancer diagnosis within 5 years before study enrollment | Diagnostic Test: Blood and urine diagnostic evaluation<br>* Blood and urine samples will be obtained from both case and control groups in order to evaluate EDCs concentrations<br>|
| Control group<br>Patients without clinical diagnosis of thyroid disease | Diagnostic Test: Blood and urine diagnostic evaluation<br>* Blood and urine samples will be obtained from both case and control groups in order to evaluate EDCs concentrations<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in the average levels of the main endocrine disruptors | The main endocrine disruptors evaluated will be PFAS, including: PFOA, PFOS, PFDA, PFUnA, PFHpS and possibly subsequently other categories, such as bisphenols, phthalates, parabens, PCBs, flame retardants | At recruitment | 
| Relationship between the concentrations of endocrine disruptors and anamnestic variables | Relationship between the concentrations of endocrine disruptors and some anamnestic variables studied (for example the type of diet, the use of personal care products). | At recruitment |