Effect of Collagen Peptides, in Combination With Resistance Training, on Body Composition and Muscle Strength in Untrained Men

Study Overview
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Brief Summary
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The effect of resistance training with post-exercise Collagen peptides (CP) supplementation on lean body mass, maximal and explosive, isometric muscle strength as well as fat mass, resting metabolism, health parameters and plasma lipid profile compared to resistance training alone will be evaluated in a group of untrained overweight male (30-60 yrs) population in a randomized controlled trial (RCT).

Detailed Description
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Participants will perform supervised resistance training involving (Leg press, pull down, chest press, back extension and abdominal crunches) 3 times a week for 12 weeks. Participants will consume either placebo or collagen peptides (in a double blinded study design) just following resistance training on training days (And approximately the same time of day on non-training days). Prior to, and following 12 weeks of exercise, participants will be tested in body composition, maximal and explosive, isometric muscle strength, resting metabolism, health parameters and plasma lipid profile Participants are healthy untrained overweight males (30-60 yrs)

Official Title
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Effect of Collagen Peptides, in Combination With Resistance Training, on Body Composition and Muscle Strength in Untrained Men

Conditions
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Body Composition, Lean Body Mass, Muscle Strength, Muscle Power

Intervention / Treatment
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* Dietary Supplement: Effect of collagen peptides, in combination with resistance training, on body composition and muscle strength compared to placebo in untrained men
* Dietary Supplement: Placebo Control intervention: Effect of resistance training in combination with placebo (silicon dioxide), on body composition and muscle strength in untrained men


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male, between 30 and 60 years of age Fat mass >25 % as measured by bioelectrical impedance analysis Stable weight (±5 %) and eating behaviour within the last 3 months. Signed informed consent Exclusion Criteria: Regular physical activity >60 min / week Stabile or progressive diseases/conditions (including medication) contraindicating or disabling participation in intensive exercise training and/or with potential to affect training adaptation beyond normal variation. For example: Contraindications against physical stress corresponding guidelines of American College of Sports Medicine (ACSM) Subjective symptoms during exercise (e.g., unusual physical exhaustion, dyspnoea, nausea) Moderate to severe mobility limitation (i.e., due to rheumatic disease) Diagnosis of cancer within the last 5 years Diabetes mellitus I and II uncontrolled arterial hypertension (systolic blood pressure >155 for mmHg and/or diastolic blood pressure >94 mm Hg; mild hypertension under resting condition will be allowed but such participants will be recommended to consult their general practitioner). Conditions contraindicating the supplementation protocol. Contraindications against nutritional or ergogenic supplements Allergy/aversion against animal protein Liver or kidney diseases with a non-permission to ingest certain concentrations of protein.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: A double blinded randomized controlled trial
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Collagen peptide group<br>This group will consume 1 serving of Collagen peptides, which is produced and marketed ® by GELITA AG, Germany under the brand name BODYBALANC each day. | Dietary Supplement: Effect of collagen peptides, in combination with resistance training, on body composition and muscle strength compared to placebo in untrained men<br>* The effects of collagen peptide consumption in combination with resistance training will be tested<br>|
| Placebo Comparator: Placebo group<br>This group will consume 1 serving of silicon dioxide (Sipernat 350, Evonik, Germany) each day. The product is absorbed in negligible amounts by the intestine and does therefore induce minor metabolic effects. | Dietary Supplement: Placebo Control intervention: Effect of resistance training in combination with placebo (silicon dioxide), on body composition and muscle strength in untrained men<br>* The effects of placebo consumption in combination with resistance training will be tested<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lean body mass (kg) | Lean body mass measured by dual-energy X-ray absorptiometry (DXA) | Pre (1week prior to intervention) and post (1 week following intervention. i.e 14weeks after inclusion) intervention - about 20 minutes for all dxa-measurements | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fat mass (kg) | Fat mass measured by dual-energy X-ray absorptiometry (DXA) | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 20 minutes for all dxa-measurements | 
| Resting energy expenditure (kcal pr. day) | Resting energy expenditure measured with the ventilated hood and indirect calorimetry | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - 15-25 minutes for all dxa-measurements | 
| 1 Repetition maximum strength (kg) | 1 repetition maximum strength in leg press, pull down and chest press | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 25 minutes for all 1RM measurements | 
| Maximal isometric knee extensor force (Nm) | Maximal isometric knee extensor force | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 25 minutes for all isokinetic dynamometer measurements | 
| Rate of force development (Nm/sec) | Unilateral rate of force development from onset of force until 0-30, 0-50, 0-100, 0-200ms of the knee extensor | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 25 minutes for all isokinetic dynamometer measurements | 
| Knee extensor power (W) | Unilateral knee extensor power (W) | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 15 minutes | 
| Sit to stand | 30 second sit to stand test | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 3 minutes | 
| Full body bone mineral density (g/cm^2) | Full body bone mineral density (BMD) (obtained by DEXA) | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 20 minutes for all dxa-measurements |