Familial B-cell Lymphoproliferative Disorders

Study Overview
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Brief Summary
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This study investigates families with at least two cases of B-cell lymphoproliferative disorders (LPD), and evaluates the prevalence of LPD in families, the relationship between medical history, genetic factors, and the risk of familial LPD, and various clinical outcomes for these families in a multiethnic population of Jews and Arabs in Israel.

Official Title
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Epidemiology of Familial B-cell Lymphoproliferative Disorders

Conditions
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Lymphoproliferative Disorders, Premalignant, Monoclonal B-Cell Lymphocytosis, Chronic Lymphocytic Leukemia

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient inclusion criteria: Patients must have LPD and must have a family history of LPD. LPD patients who signed an informed consent to participate in the study. Criteria for the inclusion of relatives of patients: Relatives must be related by blood to LPD patients or unrelated (for control group). Relatives who signed an informed consent to participate in the study. Exclusion Criteria: Pregnant women, special populations and those lacking judgment will not be included

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Bnai Zion Medical Center<br>Bnai Zion Medical Center | Other: No intervention<br>* No intervention<br>|
| Tel Aviv Sourasky Medical Center - Ichilov Hospital<br>Tel Aviv Sourasky Medical Center - Ichilov Hospital | Other: No intervention<br>* No intervention<br>|
| Galil Medical Center<br>Galil Medical Center | Other: No intervention<br>* No intervention<br>|
| Ziv Medical Center<br>Ziv Medical Center | Other: No intervention<br>* No intervention<br>|
| Emek Medical Center<br>Emek Medical Center | Other: No intervention<br>* No intervention<br>|
| Beilinson Hospital<br>Beilinson Hospital | Other: No intervention<br>* No intervention<br>|
| Meir Medical Center<br>Meir Medical Center | Other: No intervention<br>* No intervention<br>|
| Kaplan Medical Center<br>Kaplan Medical Center | Other: No intervention<br>* No intervention<br>|
| Sheba Medical Center<br>Sheba Medical Center | Other: No intervention<br>* No intervention<br>|
| Rambam Medical Center<br>Rambam Medical Center | Other: No intervention<br>* No intervention<br>|
| Shaare Zdek Medical Center<br>Shaare Zdek Medical Center | Other: No intervention<br>* No intervention<br>|
| Hadassah Medical Center<br>Hadassah Medical Center | Other: No intervention<br>* No intervention<br>|
| Shamir Medical Center (Assaf Harofeh)<br>Shamir Medical Center (Assaf Harofeh) | Other: No intervention<br>* No intervention<br>|
| Soroka Medical Center<br>Soroka Medical Center | Other: No intervention<br>* No intervention<br>|
| Assuta Ashdod Hospital<br>Assuta Ashdod Hospital | Other: No intervention<br>* No intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prevalence of familial LPD in Israel |  | 5 years | 
| Association between medical history and genetic variants and the risk of familial LPD |  | 5 years | 
| Risk of clinical outcomes among familial LPD and family members |  | 15 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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lymphoproliferative disorders, Chronic Lymphocytic Leukemia, Monoclonal B-cell Lymphocytosis