Diagnostic and Prognostic Value of New Quick Tests of Action Slowing in Stroke and in Cognitive Neurodegenerative Disease

Study Overview
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Brief Summary
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A large series of recent studies have documented the frequency of the slowing of the action in brain diseases, especially vascular and neurodegenerative diseases. In stroke, the predictive value of action slowing at the acute phase for predicting post-stroke functional outcome remains poorly investigated. In neurodegenerative diseases, the diagnostic relevance of the slowing at the prodromal stage remains unknown and this diagnostic requires new tests. Finally, in terms of anatomical determinants, few studies have studied the determinants of action slowing. The objectives of this project are to Determine the diagnostic and prognostic value of action slowing assessed with new quick tests in patients with acute stroke (Neurovascular Unit) and cognitive neurodegenerative disorders (Alzheimer Disease (AD), Lewy Body disease (LBD), Fronto Temporal lobar degeneration (FTLD), Cortico Basal Degeneration (CBD) and Progressive Supra Nuclear Palsy (PSNP)) and to define the lesion determinants with VBM and VLSM

Official Title
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Diagnostic and Prognostic Value of New Quick Tests of Action Slowing in Stroke and in Cognitive Neurodegenerative Disease

Conditions
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Stroke, Action Speed, Dementia Mild Cognitive Impairment, Alzheimer Disease

Intervention / Treatment
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* Other: quick tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients between 40 and 85 years old, French native language, Social Security affiliation. University Memory Clinic for: Mild severity disorder (MMSE> 19) or major severity disorder related to AD : Albert 2011 criteria ; McKhann 2011 to MCL according to McKeith criteria to FTLD according to Rascovsky 2011 criteria BBD according to Armstrong's criteria related to PSP according to Höglinger criteria Exclusion Criteria: Mental retardation or guardianship Previously diagnosed dementia Other current or past brain condition severe head trauma epilepsy prior to stroke still requiring previous treatment Parkinson disease, multiple sclerosis... brain tumor or brain radiation therapy Current or past schizophrenia or psychosis Active or past psychiatric disorders requiring a stay> 2 days in a specialized environment Contra indication to MRI Comorbidity with life expectancy <1 year Comorbidity affecting cognition in particular: Alcohol (> 3 glasses / day) or history of alcohol withdrawal syndrome opiate or cocaine addiction or opiate withdrawal syndrome renal failure (dialysis or creatinine clearance <30) hepatic failure (spontaneous INR> 1.5 or PT <60%) respiratory failure requiring oxygen therapy heart failure (orthopnea> 2 pillows) persistent vigilance disturbances (NIHSS1a score ≤1) cancer with paraneoplastic syndrome treatment with gold salts, D Penicillamine or other treatment with cognitive effect Patient under guardianship or curators or private under public law Pregnant and / or lactating wom

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| acute stroke patients<br> | Other: quick tests<br>* New quick tests are Batterie MindPlus (Brevet n° FR1908081, Suarez 2019) is a quick reaction time battery and Minimal Cognitive Evaluation (MCE) test (Sardi et al, 2019) is a cognitive screening tests including a specific assessment of slowing<br>|
| cognitive neurodegenerative disorders<br>cognitive neurodegenerative disorders (Alzheimer Disease (AD), Lewy Body disease (LBD), FrontoTemporal lobar degeneration (FTLD), Cortico Basal Degeneration (CBD) and Progressive Supra Nuclear Palsy (PSNP) | Other: quick tests<br>* New quick tests are Batterie MindPlus (Brevet n° FR1908081, Suarez 2019) is a quick reaction time battery and Minimal Cognitive Evaluation (MCE) test (Sardi et al, 2019) is a cognitive screening tests including a specific assessment of slowing<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Value of the speed of the action with the 'RT Componential Analysis of Action Speed' battery in all patients | RT Componential Analysis of Action Speed | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Speed values of action measured in all patients with the MindPlus battery in all patients |  | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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executive processes, attention, Stroke, action speed, Diagnostic, sensitivity, specificity, dementia mild cognitive impairment, Alzheimer disease