RARC vs LRC in A Multicenter Cohort Study

Study Overview
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Brief Summary
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A multicenter, retrospective research was conducted. Patients who underwent robot-assisted radical cystectomy and laparoscopic radical cystectomy in 10 large medical centers in China were enrolled, comparing the oncologic outcomes of the patients.

Official Title
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Robot-Assisted Versus Conventional Laparoscopic Radical Cystectomy in A Multicenter Cohort Study: A Propensity Score Matching Analysis

Conditions
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Bladder Cancer

Intervention / Treatment
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* Procedure: Robot-assisted radical cystectomy
* Procedure: Conventional laparoscopic radical cystectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: >18 years old; Clinical stage Ta-T4a/N0-3/M0 Exclusion Criteria: Severe cardiovascular disease; History of previous major abdominopelvic surgery; Patients with distant metastases; Medical history of malignancy in other organs.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sun Yat-sen Memorial Hospital<br> | Procedure: Robot-assisted radical cystectomy<br>* Robot-assisted laparoscopic radical cystectomy<br>Procedure: Conventional laparoscopic radical cystectomy<br>* Conventional laparoscopic radical cystectomy<br>|
| Renji Hospital, Shanghai Jiaotong University School of Medicine<br> | Procedure: Robot-assisted radical cystectomy<br>* Robot-assisted laparoscopic radical cystectomy<br>Procedure: Conventional laparoscopic radical cystectomy<br>* Conventional laparoscopic radical cystectomy<br>|
| The Third Medical Centre of Chinese PLA General Hospital<br> | Procedure: Robot-assisted radical cystectomy<br>* Robot-assisted laparoscopic radical cystectomy<br>Procedure: Conventional laparoscopic radical cystectomy<br>* Conventional laparoscopic radical cystectomy<br>|
| The First Affiliated Hospital of Nanchang University<br> | Procedure: Robot-assisted radical cystectomy<br>* Robot-assisted laparoscopic radical cystectomy<br>Procedure: Conventional laparoscopic radical cystectomy<br>* Conventional laparoscopic radical cystectomy<br>|
| Peking University Third Hospital<br> | Procedure: Robot-assisted radical cystectomy<br>* Robot-assisted laparoscopic radical cystectomy<br>Procedure: Conventional laparoscopic radical cystectomy<br>* Conventional laparoscopic radical cystectomy<br>|
| The Second Xiangya Hospital, Central South University<br> | Procedure: Robot-assisted radical cystectomy<br>* Robot-assisted laparoscopic radical cystectomy<br>Procedure: Conventional laparoscopic radical cystectomy<br>* Conventional laparoscopic radical cystectomy<br>|
| Zhongda Hospital Southeast University<br> | Procedure: Robot-assisted radical cystectomy<br>* Robot-assisted laparoscopic radical cystectomy<br>Procedure: Conventional laparoscopic radical cystectomy<br>* Conventional laparoscopic radical cystectomy<br>|
| The First Hospital of Jilin University<br> | Procedure: Robot-assisted radical cystectomy<br>* Robot-assisted laparoscopic radical cystectomy<br>Procedure: Conventional laparoscopic radical cystectomy<br>* Conventional laparoscopic radical cystectomy<br>|
| Second Hospital of Dalian Medical University<br> | Procedure: Robot-assisted radical cystectomy<br>* Robot-assisted laparoscopic radical cystectomy<br>Procedure: Conventional laparoscopic radical cystectomy<br>* Conventional laparoscopic radical cystectomy<br>|
| Gansu Provincial Hospital<br> | Procedure: Robot-assisted radical cystectomy<br>* Robot-assisted laparoscopic radical cystectomy<br>Procedure: Conventional laparoscopic radical cystectomy<br>* Conventional laparoscopic radical cystectomy<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall Survival | Time from surgery until death from any cause. | Five years | 
| Recurrence-free Survival | Time from surgery to tumor recurrence which identified either pathologically or radiographically. | Five years | 
| Cancer-specific Survival | Time from date of surgery to death from bladder cancer. | Five years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bladder cancer, Radical cystectomy, Robot-assisted laparoscopy, Conventional laparoscopy