Assessment of Lipid Profile in Juvenile Systemic Lupus Erythematosus

Study Overview
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Brief Summary
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. To determine pattern and frequency of dyslipoproteinemia in patients with newly diagnosed juvenile SLE and to assess effect of disease activity on lipid profile of patients with juvenile SLE.

Detailed Description
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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem inflammation and the presence of circulating autoantibodies against self-antigens leading to inflammatory damage of many target organs including the skin, joints, kidneys, blood cells, blood vessels, and the central nervous system.Premature atherosclerosis has been recognized as an important issue for patients with SLE since the mid-1970s. Among the traditional risk factors of atherosclerosis, a history of smoking, diabetes, hypertension, and abnormal lipid profile have been shown to be important (7). In patients with juvenile SLE, smoking, diabetes, and uncontrolled hypertension are not common and therefore abnormal lipid profiles may be the most important risk factor.The lipid profile of both children and adults with SLE is the result of a combination of the influences of active disease, therapies, and genetics. The best way to determine the maximal potential effect of disease activity itself would be to examine patients at the time of presentation of SLE, when they are likely to have high disease activity but no effect of corticosteroid therapy.Studies in patients with active SLE suggested that there is a distinct pattern of lipid abnormalities of increased very low-density lipoprotein (VLDL) and triglycerides and decreased high-density lipoprotein (HDL-C), cholesterol and apolipoprotein A1 levels (active SLE pattern)

Official Title
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Assessment of Lipid Profile in Juvenile Systemic Lupus Erythematosus

Conditions
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Systemic Lupus Erythematosus

Intervention / Treatment
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* Other: lipid profile


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who are diagnosed according to 2019 European League against Rheumatism (EULAR) /American College of Rheumatology (ACR) SLE classification criteria . Patients diagnosed with jSLE between 5 and 18 years of age Exclusion Criteria: 1. Patients on lipid lowering drugs for any other reason. 2. Patients with other autoimmune disease.

Ages Eligible for Study
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Minimum Age: 5 Years
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| newly diagnosed juvenile systemic lupus erythematosus<br> | Other: lipid profile<br>* Measurements for CHOL,TG,LDL-C and HDL-C obtained following an overnight fasting<br>|
| old cases of juvenile systemic lupus in activity<br> | Other: lipid profile<br>* Measurements for CHOL,TG,LDL-C and HDL-C obtained following an overnight fasting<br>|
| old cases of juvenile systemic lupus not in activity(controlled)<br> | Other: lipid profile<br>* Measurements for CHOL,TG,LDL-C and HDL-C obtained following an overnight fasting<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| lipid profile | pattern and frequency of dyslipoproteinemia in patients with newly diagnosed JSLE . | 2 years | 
| lipid profile | effect of disease activity on lipid profile of patients with JSLE | 2 years |