Evaluation of Serum Pentraxin 3 and High Sensitive CRP in Female Patients With Gestational Diabetes Mellitus in Second Trimester of Pregnancy

Study Overview
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Brief Summary
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To assess the value of serum Pentraxin-3 and high sensitive CRP in females with normal pregnancy and females with gestational diabetes mellitus in second trimester of pregnancy. To study correlations between serum Pentraxin-3 and High sensitive CRP in gestational diabetes.

Detailed Description
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Gestational diabetes mellitus (GDM) refers to abnormal glucose metabolism that occurs or is discovered during pregnancy, it can cause multiple poor outcomes and increase maternal and child prevalence and mortality. GDM can increase the risk of type 2 diabetes mellitus (T2DM) and cardiovascular diseases in pregnant women, and the risk of metabolic disorders in their offspring is high, so it's called a disease that affects two generations.(1) The relationship between maternal hyperglycemia and fetal macrosomia together with other complications has been confirmed.(2) Women with GDM have a higher long-term risk of type 2 diabetes mellitus.(3) Pentraxin 3 (PTX3) and high sensitive CRP are both the acute phase proteins belonging to the pentraxin family but with different biological characteristics, CRP belongs to the short PTX, which is an acute phase protein synthesized by the hepatocytes when the body is stimulated by microbial invasion or tissue damage.(4) PTX3 is a long-chain PTX protein. A variety of tissue cells can produce PTX3 under the stimulation of pro-inflammatory factors, including the endothelial cells, fibroblasts, monocytes, adipocytes, etc.(5,6) There is one study(Changes of serum pentraxin-3 and hypersensitive CRP levels during pregnancy and their relationship with gestational diabetes mellitus , 2019) , that has come to PTX3 and hs-CRP may be related to the pathogenesis of GDM, and they are significantly increased in the second trimester, which provides a new idea for early prevention and treatment of GDM .

Official Title
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Evaluation of Serum Pentraxin 3 and High Sensitive CRP in Female Patients With Gestational Diabetes Mellitus in Second Trimester of Pregnancy.

Conditions
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Gestational Diabetes Mellitus in Second Trimester of Pregnancy

Intervention / Treatment
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* Diagnostic Test: serum pentraxin 3 and high sensitive CRP


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pregnant women. Diagnosed GDM. 3Gestational age >20weeks Exclusion Criteria: Women with pregestational diabetes . Women with chronic diseases. Twin pregnancy.
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Interventional Model Description: Evaluation of serum pentraxin 3 and high sensitive CRP in female patients with gestational diabetes mellitus in second trimester of pregnancy.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: serum pentraxin 3 and high sensitive CRP<br>female with gestational diabetes mellitus in 2nd trimester | Diagnostic Test: serum pentraxin 3 and high sensitive CRP<br>* serum pentraxin 3 and high sensitive CRP<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean different in concentration of serum pentraxin-3 and high sensitive CRP levels in study groups. | female patients with gestational diabetes mellitus in second trimester of pregnancy | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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serum pentraxin 3,high sensitive CRP in female patients with gestational diabetes mellitus