Effect of Intravenous Dextrose on PONV in Patients Undergoing Gynecological Laparoscopy

Study Overview
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Brief Summary
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This study is to explore the relationship between intravenous infusion of dextrose during emergence from anesthesia and the incidence of PONV in patients undergoing gynecology laparoscopy (GL).

Official Title
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Research Investigator

Conditions
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Postoperative Nausea and Vomiting

Intervention / Treatment
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* Other: 5% glucose
* Other: lactated ringers


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA I or II; Performing gynecologic laparoscopic procedures under general anesthesia; Exclusion Criteria: age <18 or >75 severe hypertension,diabetes mellitus, significant hepatic or renal disease inability to follow protocol refusal to participant

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Experimental group<br>Patients in the experimental group were infused intravenously with 5% dextrose (400 ml/h) in the PACU. The study outcomes were collected at three assessment periods, 0-0.5 h, 0.5-6 h, 6-24 h, after anesthesia by an independent investigator. | Other: 5% glucose<br>* Patients in the experimental group were infused intravenously with 5% dextrose (500 ml/h) in the PACU.<br>* Other names: 5% dextrose;|
| Active Comparator: Control group<br>Patients in the control group were infused intravenously with ringer lactate solution (400 ml/h) in the PACU. The study outcomes were collected at three assessment periods, 0-0.5 h, 0.5-6 h, 6-24 h, after anesthesia by an independent investigator. | Other: lactated ringers<br>* Patients in the control group were infused intravenously with lactated ringers (500 ml/h) in the PACU.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative nausea and vomiting | The severity and incidence of PONV at 0.5 hours postoperatively. | Measured at 0.5 hours postoperatively. | 
| Postoperative nausea and vomiting | The severity and incidence of PONV at 2 hours postoperatively. | Measured at 2 hours postoperatively. | 
| Postoperative nausea and vomiting | The severity and incidence of PONV at 24 hours postoperatively. | Measured at 24 hours postoperatively. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Consumption of postoperative analgesic | Record the type and dosage of postoperative analgesic within 24 hours after surgery. | Approximately 24 hours after surgery. | 
| Postoperative pain response | The Visual Analog Score was used to assess pain response at 0.5 hours postoperatively. The score ranges from 0 (pain free or no pain) to 10 (worst pain). | Measured at 0.5 hours postoperatively. | 
| Postoperative pain response | The Visual Analog Score was used to assess pain response at 2 hours postoperatively. The score ranges from 0 (pain free or no pain) to 10 (worst pain). | Measured at 2 hours postoperatively. | 
| Postoperative pain response | The Visual Analog Score was used to assess pain response at 24 hours postoperatively. The score ranges from 0 (pain free or no pain) to 10 (worst pain). | Measured at 24 hours postoperatively. | 
| Recovery time of PACU | Record PACU recovery time in hours. The criteria for discharge from PACU was the achievement of a modified Aldrete score ≥ 9. | Approximately 24 hours after surgery. | 
| Consumption of postoperative rescue antiemetic | Record the type and dosage of postoperative rescue antiemetic within 24 hours after surgery. | Approximately 24 hours after surgery. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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PONV