Evaluation of the Role of Poisoning Severity Score, Serum Procalcitonin and C-reactive Protein in Acute Hydrocarbon Intoxicated Cases Admitted to the Poison Control Center Ain Shams University Hospitals

Study Overview
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Brief Summary
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Hydrocarbons are a primary energy source in modern society. They are present in many common household and occupational products, including motor fuels, paint thinners, cleaning agents, lotions, and industrial solvents. Unfortunately, these products are also used as agents of abuse and typically inhaled . They are derived mainly from petroleum (kerosene, gas, naphtha) or wood (turpentine, pine oil). They can be found in liquid, gas, or solid form depending on their properties. All hydrocarbons can be toxic, but aromatic (ring-shaped) and halogenated hydrocarbons typically have more severe toxicity . Toxicity occurs in various ways including through inhalation, ingestion, aspiration, and dermal exposure. Frequently, these exposures occur during attempted recreational use of the substances and sometimes for self-injurious behavior

Official Title
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Evaluation of the Role of Poisoning Severity Score, Serum Procalcitonin and C-reactive Protein in Acute Hydrocarbon Intoxicated Cases Admitted to the Poison Control Center Ain Shams University Hospitals

Conditions
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Acute Hydrocarbon Toxicity

Intervention / Treatment
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* Diagnostic Test: serum procalcitonin
* Diagnostic Test: C-reactive protein


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients of both sexes admitted to the Poison control center, Ain Shams university hospitals with acute hydrocarbon toxicity during the duration from December 2023 till December 2024 with a maximum number of 60 cases within 24 hours of intoxication. Exclusion Criteria: Patients with these criteria will be excluded: Cases > 24 hours of intoxication. Cases with occupational exposure to hydrocarbons. Pregnant females. Any cases received any treatment before arrival to the PCC. Cases suffering from cardiac, respiratory, renal, hepatic or haematological disorders. Cases presenting with fever. Cases with other causes that can increase levels of CRP & pro-calcitonin as bacterial infection, recent major trauma, major burn ,septic shock and medullary thyroid cancer.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| control group<br>20 subjects of apparently healthy persons for estimating the standard levels of the tested biomarkers. | Diagnostic Test: serum procalcitonin<br>* predicting the severity of intoxication<br>Diagnostic Test: C-reactive protein<br>* predicting the severity of intoxication<br>|
| case group<br>60 patients divided into mild, moderate and severe toxicity according to the poisoning severity score. | Diagnostic Test: serum procalcitonin<br>* predicting the severity of intoxication<br>Diagnostic Test: C-reactive protein<br>* predicting the severity of intoxication<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum procalcitonin level | measuring the level of serum procalcitonin (reference range 0-0.05µg/L) | 1 year |