Influence of Thoracic Outlet Syndrome Severity on Upper Extremity Function and Neural Integrity

Study Overview
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Brief Summary
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The purpose of this study is to investigate the relationship between the severity of thoracic outlet syndrome and upper extremity function, as well as neural integrity.

Official Title
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The Influence of Thoracic Outlet Syndrome Severity on Upper Extremity Function and Neural Integrity: A Cross-Sectional Study

Conditions
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Thoracic Outlet Syndrome

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18-65 years Diagnosed with thoracic outlet syndrome Willing and able to provide informed consent Exclusion Criteria: History of upper extremity surgery unrelated to thoracic outlet syndrome Other upper extremity disorders unrelated to thoracic outlet syndrome

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cohort 1 (Mild)<br>Participants with mild self-reported thoracic outlet syndrome symptoms (visual analog scale score 1-3). | Other: No intervention<br>* This is an observational cross-sectional study. No intervention will be provided. Participants will be assessed and stratified into four cohorts based on self-reported symptom severity of thoracic outlet syndrome using a visual analog scale (VAS) to investigate the relationship between symptom severity and upper extremity function/neural integrity.<br>|
| Cohort 2 (Moderate)<br>Participants with moderate self-reported thoracic outlet syndrome symptoms (visual analog scale score 4-6). No intervention will be provided. | Other: No intervention<br>* This is an observational cross-sectional study. No intervention will be provided. Participants will be assessed and stratified into four cohorts based on self-reported symptom severity of thoracic outlet syndrome using a visual analog scale (VAS) to investigate the relationship between symptom severity and upper extremity function/neural integrity.<br>|
| Cohort 3 (Severe)<br>participants with severe self-reported thoracic outlet syndrome symptoms (visual analog scale score 7-9). No intervention will be provided | Other: No intervention<br>* This is an observational cross-sectional study. No intervention will be provided. Participants will be assessed and stratified into four cohorts based on self-reported symptom severity of thoracic outlet syndrome using a visual analog scale (VAS) to investigate the relationship between symptom severity and upper extremity function/neural integrity.<br>|
| Cohort 4 (Very Severe)<br>Participants with very severe self-reported thoracic outlet syndrome symptoms (visual analog scale score 10). No intervention will be provided. | Other: No intervention<br>* This is an observational cross-sectional study. No intervention will be provided. Participants will be assessed and stratified into four cohorts based on self-reported symptom severity of thoracic outlet syndrome using a visual analog scale (VAS) to investigate the relationship between symptom severity and upper extremity function/neural integrity.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Range of Motion (ROM) of the Shoulder joint | Active and passive ROM will be measured using a standard goniometer. | Baseline | 
| Range of Motion (ROM) of the Elbow joint | Active and passive ROM will be measured using a standard goniometer. | Baseline | 
| Range of Motion (ROM) of the Wrist joint | Active and passive ROM will be measured using a standard goniometer. | Baseline | 
| Isometric Muscle Strength of shoulder | Maximum voluntary isometric strength of shoulder muscles will be measured using a handheld dynamometer. | Baseline | 
| Isometric Muscle Strength of elbow | Maximum voluntary isometric strength of elbow muscles will be measured using a handheld dynamometer. | Baseline | 
| Isometric Muscle Strength of wrist | Maximum voluntary isometric strength of wrist muscles will be measured using a handheld dynamometer. | Baseline | 
| Self-reported upper extremity function | The Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire, developed by the Institute for Work and Health, is used to measure patient-reported functional outcomes. The DASH questionnaire consists of 30 questions regarding limitations to complete physical activities due to upper extremity pain/impairment. Participants will be asked to respond to each question based on their experiences over the preceding week according to a 5-point Likert scale ranging from 1 (no difficulty) to 5 (unable to do). Responses will be scored out of 5 and averaged to produce a score out of 100 with higher scores representing greater disability. | Baseline | 
| Nerve Conduction Studies of ulnar nerve | Nerve conduction studies will assess the function/integrity of the ulnar nerve. | Baseline |