Non-alcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome

Study Overview
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Brief Summary
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This study was planned to examine the prevalence of vitamin D insufficiency, insulin resistance, non-alcoholic fatty liver disease (NAFLD), and their relationship with each other and the nutritional status of individuals with polycystic ovary syndrome (PCOS) in reproductive age, by evaluating anthropometric, biochemical, and ultrasonographic findings and food consumption frequency data.

Detailed Description
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A total of 72 female individuals diagnosed with PCOS were included in the study. Nutritional status, physical activity levels, anthropometric measurements, and biochemical parameters of individuals were examined. A food consumption frequency questionnaire was applied to the individuals. According to the 2003 Rotterdam Consensus revision, PCOS is diagnosed when at least two of the following three conditions are present: Polycystic ovaries on ultrasonography, oligomenorrhoea, or anovulation; clinical and/or biochemical symptoms of hyperandrogenemia. Testing was done on insulin, lipid profiles, fasting plasma glucose, and liver function. Bioelectrical impedance analysis was used to determine body weight and composition. An abdominal ultrasound was used to diagnose NAFLD.

Official Title
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Assessment of Non-alcoholic Fatty Liver Disease and Risk Factors in Women With Polycystic Ovary Syndrome

Conditions
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PCOS, NAFLD

Intervention / Treatment
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* Other: Questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: female sex PCOS diagnosis no use of oral contraceptives or any hormone therapy in the last 3 months no use of vitamin D supplements in the last 3 months no use of oral antidiabetic drugs in the last 3 months Exclusion Criteria: adrenal dysfunction diabetes mellitus pregnancy alcohol consumption a history of chronic viral hepatitis autoimmune liver disease other liver diseases history of hepatotoxicity use of antihypertensive, antidiabetic, lipid-lowering drugs

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Women with Polycystic ovary syndrome (PCOS)<br>PCOS was diagnosed according to the revised 2003 Rotterdam Consensus as the presence of at least two of the following three criteria: (i)oligomenorrhoea or anovulation; (ii)clinical and/or biochemical signs of hyperandrogenemia and (iii)polycystic ovaries on ultrasound. | Other: Questionnaire<br>* Nutritional status, physical activity levels, anthropometric measurements, and biochemical parameters of individuals were examined. A food consumption frequency questionnaire was administered.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum vitamin D levels | Serum vitamin D levels were measured by immunoassay analyzer. | 3 months | 
| Insulin resistance | Insulin resistance analyzed by homeostasis model assessment-insulin resistance (HOMA-IR) formulation. | 3 months | 
| Non-alcoholic fatty liver disease (NAFLD) grade | NAFLD grade was evaluated by ultrasonography. | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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polycystic ovary syndrome, non-alcoholic fatty liver disease, obesity, insulin resistance