linjc16/ctgov huggingface dataset:
Prevalence of Non-alcoholic Fatty Liver Disease in Patients With Chronic Kidney Disease in Assiut

Study Overview
=================
Brief Summary
-----------------
The goal of this observational study is to detect the prevalence of NAFLD in CKD patients The main question[s] it aims to answer are: [question 1] prevalence of NAFLD in CKD patients. [question 2] the relationship between NAFLD and CKD.

Detailed Description
-----------------
The goal of this observational study is to detect the prevalence of NAFLD in CKD patients The main question[s] it aims to answer are: [question 1] prevalence of NAFLD in CKD patients. [question 2] the relationship between NAFLD and CKD.

Official Title
-----------------
Prevalence of Non-alcoholic Fatty Liver Disease in Patients With Chronic Kidney Disease in Assiut

Conditions
-----------------
CKD, NAFLD

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: CKD patients Exclusion Criteria: HCV and HBV Positive patients Alcoholics patient on Hemodialysis patients with wilson disease patients with alpha one antitrypsin deficiency

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| CKD patients<br>CKD patient who are not DM are investigated for the presence of NAFLD | |
| normal control group<br>normal population are investigated to know the prevalence of NAFLD in contrast to patients with CKD. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| abdominal ultrasound | assessment of Liver regarding fatty liver disease by Ultrasound. | 1 year | 
| liver enzymes | participants will undergo assessment of liver enzymes (AST and ALT) and results will be reporeted in a table. | 1 year | 
| Fibroscan | participants will undergo fibroscanning of the liver to assess NAFLD and results will be reported in a table. | 1 year | 
| BUN, Cr level and estimated GFR | participants will be assessed regarding BUN, CR and estimated GFR to confirm and follow up CKD patients involved in the study. | 1 year | 
| Lipid Profile | participants will be assessed regarding Cholesterol level, Triglycerides, HDL and LDL. results will be reported in a table | 1 year | 
| Complete Blood Picture (WBCs, HB, Patelets | total leucocytic count Hemoglobin level and platelet count will be assessed in our patients and will be reported in a table | 1 year | 
| serum Uric Acid | serum uric acid will be assessed and reported in our patients | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Waist Circumference | waist circumference measurement. | 1 year | 
| Body Mass Index | BMI will also be calculated. | 1 year |
Wait Time Preferences of the US Public for New Drugs: a Discrete Choice Experiment

Study Overview
=================
Brief Summary
-----------------
To provide timely access to new treatments, some eligible drugs can be approved despite uncertainty surrounding the level of clinical benefit they offer patients. It is not currently known if (and under which circumstances) the public would prefer to wait to access some new drugs in exchange for greater certainty surrounding their clinical benefit. This study aims to elicit the preferences of the US public for wait times and clinical uncertainty of new drugs. To elicit this information, in a survey format, respondents will be presented with a hypothetical scenario and asked to state their preferences for new treatments, each with different attributes.

Official Title
-----------------
Wait Time Preferences of the US Public for New Drugs With Uncertain Treatment Benefits: a Discrete Choice Experiment

Conditions
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Cancer

Intervention / Treatment
-----------------
* Other: Discrete Choice Experiment (DCE)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Individuals previously or currently diagnosed with any type of cancer. Individuals with immediate family members previously or currently diagnosed with any type of cancer. Exclusion Criteria: Individuals without previous or current diagnosis with any type of cancer (themselves or immediate family members).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Discrete Choice Experiment (DCE)|DCE survey experiment|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Preferences for treatment attributes and trade-offs between attributes. | Preferences for different treatment attributes (including clinical uncertainty and wait time), and trade-offs between these, using a study-specific Discrete Choice Experiment (DCE) Questionnaire. Preferences are measured on relative utility scale (arbitrary units, no min/max). Utility indicates preference e.g., higher values are more preferred (better). | Through study completion, an average of 4-8 weeks. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Discrete Choice Experiment
Patient Experiences on the Stroke Unit

Study Overview
=================
Brief Summary
-----------------
In this study we want to develop and validate a PREM for patient with ischemic stroke.

Detailed Description
-----------------
Patient Reported Experience Measures (PREMs) assess patient's perception of health care. Currently, there is no suitable PREM tool for patients with ischemic stroke. Therefore, we aim to develop and validate a PREM for this patient population. This PREM will be validated in a multicentre study, in 10 Flemish hospitals. We want to investigate the feasibility of our new questionnaire, as well as the usefulness. In addition we well analyse the results of the questionnaires and use this information to improve the quality of the care program for stroke patients.

Official Title
-----------------
Patient Experiences of the CVA Care Program on the Stroke Unit

Conditions
-----------------
Ischemic Stroke

Intervention / Treatment
-----------------
* Other: Questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: > 18 years ischemic stroke stayed at least one day at the stroke unit Exclusion Criteria: not able to read the questionnaire not able to answer question orally are not proficient in the dutch language

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Intervention<br>Completion of questionnaire | Other: Questionnaire<br>* Completion of the patient reported experience measurements (PREMs) questionnaire<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Validation of a new Patient Reported Experience Measurements (PREMs) for stroke patients | Validation of a questionnaire which was developed based on literature and consensus meeting | 6-months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient experiences | How do patients experience their received care when they are admitted to the stroke unit/neurology department | 6-months |
Inflammatory and Degenerative Muscle Disease

Study Overview
=================
Brief Summary
-----------------
Correlation between clinical , ultrasonographical, neurophysiological and histopathological findings in muscle diseases of different etiologies.

Official Title
-----------------
Neurophysiological, Sonographical and Pathological Findings in Patients With Inflammatory Versus Degenerative Muscle Diseases

Conditions
-----------------
Inflammatory Muscle Disease

Intervention / Treatment
-----------------
* Procedure: muscle biopsy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Muscle diseases of different etiologies. Any age. Exclusion Criteria: Patient refuse to participate. The anatomy is altered due to severe trauma, tumor , or surgery. Severe deformity preventing examination.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| inflammatory muscle disease<br> | Procedure: muscle biopsy<br>* true cut needle biopsy<br>* Other names: muscle ultrasound;|
| degenerative muscle disease<br> | Procedure: muscle biopsy<br>* true cut needle biopsy<br>* Other names: muscle ultrasound;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| microscopic picture of muscle in inflammatory and degenerative muscle disease | true cut needle muscle biopsy is done to differentiate between inflammatory and degenerative muscle disease in microsopic picture | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| muscle ultrasound in inflammatory and degenerative muscle disease | muscle ultrasound picture and dimensions in inflammatory and degenerative muscle disease | 1 year | 
| neurophysiology in inflammatory and degenerative muscle disease | electromyography changes in inflammatory and degenerative muscle disease | 1 year |
Anesthetists After the Pandemic in the Eyes of the Public

Study Overview
=================
Brief Summary
-----------------
Anaesthesia and anesthesiologist from the very beginning has obtained Behind the screen role. This is of great concern as the field of Anesthesiology has expanded its services to various specialities like intensive care, postoperative pain management, labour analgesia, accident and trauma management, casualty etc. the role assigned to the anesthesiologist remains inaccurate even during COVID 19 pandemic. The aim of this study was to evaluate general publics' perception about anesthesiologist& anesthesia in operating and especially intensive care units during COVID 19 pandemic.

Detailed Description
-----------------
Method: A questionnaire consisting of 27 questions was asked to fill by the general population via the social media. The questionnaire consists of two parts: The first part includes demographic data such as age, gender, education level, occupation; the second part includes the questions about anesthesia experience and knowledge.

Official Title
-----------------
Are Anesthetists Still Secret Heroes After the Pandemic?

Conditions
-----------------
Anesthesia, COVID-19 Pandemic

Intervention / Treatment
-----------------
* Other: questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - Subjects older than 16 years of age and not working in any health sector will be included in the study. Exclusion Criteria: if she/he doesn't want to join

Ages Eligible for Study
-----------------
Minimum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| public<br>Subjects older than 16 years of age and not working in any health sector will be included in the study. | Other: questionnaire<br>* 27 questions will be asked to public to find out what is the role of anesthetists after the covıd pandemic<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| who are the anesthesist | the anesthetist's role will be evaluated by yes-no or don't know | questionare will be administered online for a one month period. | 
| covid19 and anesthetists | Whether anesthetists' duties during the covid19 pandemic are known to the public will be evaluated with yes, no or I don't know. | questionare will be administered online for a one month period. |
Relapse and Failure Rates Between CAD/CAM and Conventional Fixed Retainers

Study Overview
=================
Brief Summary
-----------------
The aim of this study was to compare the differences in relapse and failure rates in patients treated with fixed retainers (FRs) using Computer-Aided Design/Computer-Aided Manufacturing technology, lab-based technique, and chairside method.

Official Title
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Relapse and Failure Rates Between CAD/CAM and Conventional Fixed Retainers: A 2-year Follow-up of a Randomized Controlled Clinical Trial

Conditions
-----------------
Relapse

Intervention / Treatment
-----------------
* Other: Computer Aided Design/ Computer Aided Manufacturing Retainers
* Other: Lab-based Retainers
* Other: Chairside Retainers


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: completion of comprehensive orthodontic treatment class I molar and canine relationships indication for a fixed retainer on the mandibular anterior teeth. no extractions done as part of their treatment. Treatment with preadjusted edgewise appliance. Exclusion Criteria: refusal to participate refusal to have fixed retainers poor oral hygiene non-compliance

Ages Eligible for Study
-----------------
Minimum Age: 13 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CAD/CAM group<br> | Other: Computer Aided Design/ Computer Aided Manufacturing Retainers<br>* Custom-bent fixed retainer wires from an in-office CAD/CAM system with FixR software and the BenderI machine (YOAT Corporation, Lynwood, WA). Dentaflex wires- round, 0.5mm in diameter, three-stranded Stainless Steel (Dentaurum GmbH & Co., Ispringen, Germany)- were used for the CAD/CAM group<br>* Other names: CAD/CAM;|
| Active Comparator: Lab group<br> | Other: Lab-based Retainers<br>* The lab group used the same type of wire as the CAD/CAM group but was manually bent by a lab technician<br>|
| Active Comparator: Chairside group<br> | Other: Chairside Retainers<br>* The chairside group used three-stranded Stainless Steel, 0.974mm x 0.402 mm, flexible Ortho-FlexTech wires (Reliance, Itasca, IL)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in intercanine width (ICW) | ICW was measured on the Meshlab software using the 3D ruler measurement tool. Pre-treatment, post-treatment, and post-retention measures were recorded and any change in the ICW was considered relapse. | 2 years | 
| Change in Little's Irregularity Index (LII) | ICW was measured on the Meshlab software using the 3D ruler measurement tool. Pre-treatment, post-treatment, and post-retention measures were recorded and any change in the LII was considered relapse. | 2 years |
Australian UCSF Concussion in Athletes

Study Overview
=================
Brief Summary
-----------------
Analysis of cardiac induced brain forces using cranial accelerometry has been shown to diagnose concussion in high school athletes. This trial expands on this observation by recording headpulse signals in a recently concussed athletes playing Australian rules football.

Detailed Description
-----------------
Recently concussed athletes will have headpulse measurements obtained as soon after the clinically identified concussion as is feasible and at 1-3 day intervals over the course of a month. These recordings will pair with a self administered neurological symptom inventory (NSI) to track the athletes subjective concussion symptoms. Data will be used to confirm prior models of analysis and produce a tool to be confirmed in a future study.

Official Title
-----------------
Australian UCSF Concussion in Athletes Studied With Cranial Accelerometry

Conditions
-----------------
Concussion, Mild

Intervention / Treatment
-----------------
* Device: Headpulse measurements


Participation Criteria
=================
Eligibility Criteria
-----------------
Concussion Subjects: Inclusion Criteria: Diagnosed with sport related concussion first recording obtained within one week willingness to have multiple recordings in the month following concussion Exclusions: - head laceration Control subjects: Inclusion Criteria: athletes without concussion over the last year willingness to have single or multiple recordings Exclusion Criteria: - head laceration

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Concussed<br>Diagnosis of concussion | Device: Headpulse measurements<br>* Placement of headset on subject<br>|
| Controls<br>Athletes with no concussion within the preceding year | Device: Headpulse measurements<br>* Placement of headset on subject<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivity of headpulse measurements to detect subjects with concussion | Proportion of clinically concussed athletes that have headpulse values > 2SD of control subjects | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Feasibility of subject recruitment | Number of subjects recruited during playoff season | 2.5 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
mild traumatic brain injury
Comparison Of Efficacy Of Hydrocortisone And Methyl Prednisolone In Acute Severe Asthma

Study Overview
=================
Brief Summary
-----------------
COMPARISON OF EFFICACY OF HYDROCORTISONE AND METHYLPREDNISOLONE IN ACUTE SEVERE ASTHMA In this study Investigator will compare the efficacy of hydrocortisone and methyl prednisolone in acute severe asthma that will lead to final result and beneficial effects that will help in early resoloution of symptoms and help in preventing recurrence

Detailed Description
-----------------
investigator will compare the efficacy of hydrocortisone v/s methylprednisolone in management of patients presented with acute severe asthma in emergency. A local study was conducted in 2009, after that there is a big research gap exists at national level although international literature is available on the same but it can not be generalized to our population due to socio, geographic and economic differences so there is dire need to conduct this study this gives a strong rationale to implement in our settings

Official Title
-----------------
Comparison Of Efficacy Of Hydrocortisone And Methyl Prednisolone In Acute Severe Asthma

Conditions
-----------------
Asthma Acute

Intervention / Treatment
-----------------
* Drug: Methylprednisolone,


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Either Gender (18 to 50 years old) Patient presenting to emergency department with acute severe asthma Exclusion Criteria: Patients with critical illness or pregnant females. .Patient treated other than hydrocortisone and methylprednisolone. .Patients not willing to participate in study. Life threatening asthma Near fatal asthm

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| HYDROCORTISONE<br>Group A will comprise of 30 patients will be treated with 200 mg hydrocortisone followed by 3 doses of hydrocortisone 100 mg 6 hours apart for next 24hrs | |
| METHYLPREDNISOLONE<br>Group B will be treated with methylprednisolone 125 mg stat | Drug: Methylprednisolone,<br>* No intervention required<br>* Other names: Hydrocortisone;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Spirometry | Above will be check on arrival of patient to Emergency and post Managment | 24 hours | 
| Blood pressures | Vital signs at initial presentation and post managment will be recorded Blood pressure in mm HG will be recorded | 24 hours | 
| Respiratory rate | Respiratory rate at arrival and post managment will be considered Respiratory rate in Breaths/min | 24 hours | 
| Heart rate | Heart rate beats/min will be checked | 24 hours | 
| PEAK EXPIRATORY FLOW RATE | it wil be checked on arrival and post managment in Peak Expiratory Flow rate (force expiratory volume in 1 second and force vital capacity )will be examined | 24 hours |