linjc16/ctgov huggingface dataset:
Prophylactic Lymphovenous Bypass Procedure Following Inguinal Lymphadenectomy: A Prospective Observational Study

Study Overview
=================
Brief Summary
-----------------
To learn if LBP can help to prevent lymphedema when it is performed at the time of surgery rather than after a patient has already developed the disease.

Detailed Description
-----------------
Primary Objectives: The objective of this study is to evaluate the protective benefit to performing LVB surgery at the time of ILND. In the secondary objective, we will compare the medical outcomes for patients that received the LVB surgery with those receiving standard surgery in whom the intervention could not be performed.

Official Title
-----------------
Prophylactic Lymphovenous Bypass Procedure Following Inguinal Lymphadenectomy: A Prospective Observational Study

Conditions
-----------------
Lymphadenectomy

Intervention / Treatment
-----------------
* Procedure: Lymphovenous bypass procedure


Participation Criteria
=================
Eligibility Criteria
-----------------
Eligibility Criteria: Patients greater than or equal to 18 years of age. Patients willing to participate. Patients able to complete informed consent. Patients undergoing ILND. Exclusion Criteria: Patients taking anticoagulants within 7 days prior to surgery. Patients that are known to be pregnant at the time of surgery. Patients are available for follow-up less than 18 months or do not undergo measurements within the scheduled period. Patients with BMI greater than 50.0.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Lymphovenous bypass procedure (LBP)<br>A surgical procedure for treating lymphedema called lymphovenous bypass procedure (LBP), but it is usually only done after a patient develops lymphedema | Procedure: Lymphovenous bypass procedure<br>* Participants will return to the clinic 14 days, 6 months, 12 months, 18 months, and 24 months after your surgery for measurements of your legs to see if there are changes over time<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 4.03 |  | through study completion; an average of 1 year |
Outcomes of Thyroid Auto Transplantation Following Total Thyroidectomy in Benign Thyroid Disorders Protocol

Study Overview
=================
Brief Summary
-----------------
the study aimed at evaluating efficacy of auto-transplantation of thyroid tissue after total thyroidectomy in benign thyroid disorders to keep the patient euthyroid with no need for life long hormone replacement therapy.

Detailed Description
-----------------
This study will be a prospective study which will be conducted at Sohag University Hospital after approval of the protocol the study population include . Adult patients with goiters are seen in the general surgery outpatient clinic The study included thirty studied cases presented in the outpatient clinic with benign thyroid disorders for whom total thyroidectomy was performed

Official Title
-----------------
Outcomes of Thyroid Auto Transplantation Following Total Thyroidectomy in Benign Thyroid Disorders Protocol

Conditions
-----------------
Thyroid Diseases

Intervention / Treatment
-----------------
* Procedure: total thyroidectomy followed by thyroid auto transplantation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients proved to have benign thyroid disorders operable and candidate for total thyroidectomy Adult patients who agreed and consented to do the procedure. Exclusion Criteria: Patients with high suspicion of malignancy , unfit and refused the procedure

Ages Eligible for Study
-----------------
Minimum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patient undergone total thyroidectomy followed by thyroid auto transplantation<br> | Procedure: total thyroidectomy followed by thyroid auto transplantation<br>* All studied cases received general endotracheal anaesthesia, and all underwent total thyroidectomy. Frozen section will be done intraoperative to exclude malignancy and obtain piece of healthy tissue part . Most healthy-looking part of gland was selected after complete excision. Thyroid tissue to be transplanted weighed between two and five grammes. This section was finely split into ten-fifteen fragments with scalpel. Small pocket was created in sternomastoid muscle, into which these minor fragments were implanted, and this pocket was closed with absorbable sutures to prevent displacement of implanted fragments and was marked with metallic stables, as well as good hemostasis of thyroid bed and skin was closed with subcuticular sutures using absorbable three-zero Vicryl sutures.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Thyroid function following thyroid auto transplantation after total thyroidectomy | Thyroid hormone levels will be assessed after auto transplantation of thyroid tissue from benign thyroid patients following total thyroidectomy | six months |
Pulpotomy vs Root Canal Treatment for Teeth With Symptomatic Irreversible Pulpitis

Study Overview
=================
Brief Summary
-----------------
high-quality evidence is needed to add to current knowledge and also assess the long-term outcomes for full/complete pulpotomy after carious pulpal exposure in patients with signs and symptoms indicative of irreversible pulpitis

Official Title
-----------------
Pulpotomy vs Root Canal Treatment for Teeth With Symptomatic Irreversible Pulpitis: A Randomised Control Trial

Conditions
-----------------
Pulpitis - Irreversible

Intervention / Treatment
-----------------
* Procedure: vital pulp therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: a mature permanent tooth symptoms indicative of IRP responsive to cold and EPT sensibility testing restorable and can be adequately isolated during treatment One tooth (molar or premolar) per patient. Exclusion Criteria: active periodontal disease complex medical histories unable to consent pregnant or breast-feeding excessive bleeding that cannot be controlled

Ages Eligible for Study
-----------------
Minimum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: standard root canal treatment<br>standard root canal treatment | Procedure: vital pulp therapy<br>* removal of the coronal pulp followed by placing a biocompatible material to preserve the vitality of the radicular pulp<br>|
| Active Comparator: Pulpotomy<br>vital pulp therapy | Procedure: vital pulp therapy<br>* removal of the coronal pulp followed by placing a biocompatible material to preserve the vitality of the radicular pulp<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain score | score by a numeric rating scale from 1(minimum pain) to 100 (maximum pain) | day 3 post treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain score | score by a numeric rating scale from 1(minimum pain) to 100 (maximum pain) | 6 months post treatment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
vital pulp therapy
Economic Analysis of Robotic Rectal Resection in German Health Care System

Study Overview
=================
Brief Summary
-----------------
Analysis of cost effectiveness of robotic rectal resection, either sphincter preserving or abdominoperineal extirpation, in the German diagnosis related groups (DRG) system.

Detailed Description
-----------------
Robotic surgery has many well-known benefits for patients and surgeons, while it comes with higher acquisition and maintenance costs. On the other hand, a higher proportion of minimally invasive procedures can save costs by reducing complications, decreasing hospital stays due to lower morbidity, and saving personnel. To what extent can robotic surgery be cost-covering or even profitable, depending on the postoperative course? This question is investigated under the conditions of the German DRG system.

Official Title
-----------------
Economic Analysis of Robotic Rectal Resection in German Health Care System

Conditions
-----------------
Rectal Cancer

Intervention / Treatment
-----------------
* Other: Surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18y histologically proven rectal cancer with curative therapeutic approach suitable for minimally-invasive surgery Exclusion Criteria: no rectal cancer primary open surgery

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Robotic sphincter-preserving rectal resection<br>Patients with robotic anterior or low anterior rectal resection and primary anastomosis for rectal cancer. | Other: Surgery<br>* Robotic rectal resection, either sphincter preserving or extirpation<br>|
| Robotic abdominoperineal rectal resection<br>Patients with robotic abdominoperineal rectal resection for rectal cancer. | Other: Surgery<br>* Robotic rectal resection, either sphincter preserving or extirpation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Costs of treatment | costs caused by the case | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Major Complication | Clavin Dindo Score ≥ 3 | 30 days postoperatively | 
| Length of Hospital Stay | Hospital Stay after Surgery | 3 months | 
| 30-days Readmission | Readmission within 30 days after Surgery | 30 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Economic analysis, Robotic Surgery, Rectal Cancer, Low anterior Resection, Abdominoperineal rectal extirpation
Bariatric and Metabolic Surgery in Patients Over 65 Years of Age

Study Overview
=================
Brief Summary
-----------------
A retrospective multicenter study that will analyze the results of surgical treatment of obesity in patients over 65 years of age.

Official Title
-----------------
Bariatric and Metabolic Surgery in Patients Over 65 Years of Age - a Multicenter Study

Conditions
-----------------
Obesity, Diabetes Mellitus, Type 2, Hypertension

Intervention / Treatment
-----------------
* Procedure: bariatric surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 65 years of age and more undergone bariatric surgery Exclusion Criteria: lost to follow up

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: bariatric surgery|bariatric surgeries - sleeve gastrectomy, roux-en-Y gastric bypass, one anastomosis gastric bypass, adjustable gastric band|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| weight loss after bariatric surgery | how much weight patients lost, determined by BMI | until December 31, 2022 | 
| improvement in obesity-related diseases | changes in the treatment of hypertension and diabetes type 2 - whether the diseases resolved completely or whether there was a change in medications (in accordance with the guidelines of the American Society for Metabolic and Bariatric Surgery ASMBS) | until December 31, 2022 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bariatric surgery, elderly patients, obesity-related diseases
PCOS Indirect and Intangible Economic Burden

Study Overview
=================
Brief Summary
-----------------
The primary purpose of the PCOS Indirect and Intangible Economic Buren study is to estimate the economic costs of having PCOS in terms of quality of life and work productivity. The population will include individuals with a clinical diagnosis of PCOS, individuals self-diagnosed with PCOS, individuals with symptoms of PCOS (e.g., hirsutism, irregular menstrual cycles), and demographic-matched controls without PCOS. This study is a sub-study of The PCOS Challenge Study.

Official Title
-----------------
The PCOS Indirect and Intangible Economic Burden Study. A Sub-study of the PCOS Challenge Study: For the Collection of Information to Advance Research and Improve Care for PCOS Patients

Conditions
-----------------
Polycystic Ovary Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosed with PCOS by a health professional, self-diagnosed with PCOS or individuals with PCOS symptoms Willing to sign the consent form Able to understand the registry surveys or what is being asked Exclusion Criteria: Unable to understand the surveys or what is being asked Unwilling to sign the consent form

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Target Population<br>The target population includes individuals diagnosed with PCOS by a healthcare provider, self-diagnosed with PCOS, or who are exhibiting PCOS Symptoms and willing to sign the consent. | |
| Control Population<br>The control population includes people born biologically female who have not been diagnosed with PCOS and who also do not have symptoms of PCOS. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Information | Such as responses to survey questions | One Year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pcos, polycystic ovary syndrome, polycystic ovarian syndrome, stein leventhal syndrome
Quantification of Hepatic Steatosis With Different Ultrasound Frequency

Study Overview
=================
Brief Summary
-----------------
The objective of this study is: (1) to compare the feasibility (technical successes rate and reliability) in measuring attenuation coefficient between two different frequencies (3MHz, 4MHz) of ultrasound beam; (2) to evaluate and compare the diagnostic performance of attenuation coefficient for steatosis using two different frequencies (3MHz, 4MHz) of ultrasound beam by comparison with the pathologic results acquired by liver biopsy or surgery.

Detailed Description
-----------------
Investigators measure the distance between the skin and liver capsule on B-mod images. Investigators place a region of interest (ROI) avoiding reverberation artifacts and acquire attenuation coefficient for five times. For participants who require a liver biopsy, investigators try to target the same area in the liver, where ROI was placed. Investigators evaluate hepatic steatosis, lobular inflammation, and fibrosis of tissue of the liver using a scoring system suggested by Nonalcoholic Steatohepatitis Clinical Research Network.

Official Title
-----------------
Quantification of Hepatic Steatosis in Patients With Fatty Liver Disease Using Attenuation Imaging With Different Ultrasound Frequency

Conditions
-----------------
Fatty Liver, Fatty Liver, Nonalcoholic, Ultrasound

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Participants who are candidates for liver donation and scheduled liver biopsies for assessment of hepatic steatosis Participants suspected of nonalcoholic fatty liver disease and scheduled for liver biopsy or surgery Exclusion Criteria: Participants with a BMI of less than 23 Participants underwent liver transplantation or right hepatectomy Participants who have a large mass in the right liver Participants who have a bleeding tendency (platelet count < 80000, prothrombin time and international normalized ratio > 1.5)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Attenuation coefficient (3MHz vs. 4MHz) in attenuating imaging | dB/cm/MHz | During procedure | 
| Percentage of fat within hepatocyte in pathological specimen | S0 (<5%), S1(5% 33%), S2(34% 66%), and S3 (>66%) | During procedure | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hepatic steatosis, Quantification, Ultrasound, Attenuation coefficient
Safety and Performance Evaluation of the Nephronyx System for the Treatment of Patients With ADHF

Study Overview
=================
Brief Summary
-----------------
The objective of this interventional study is to evaluate the safety and functional performance of the Nephronyx System in patients with ADHF, presenting clinical signs of volume overload and compromised response to diuretics.

Official Title
-----------------
Safety and Performance Evaluation of the Nephronyx System for the Treatment of Patients With ADHF

Conditions
-----------------
Acute Decompensated Heart Failure

Intervention / Treatment
-----------------
* Device: Nephronyx system (Perfuser)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient admitted to the hospital with a primary diagnosis of ADHF Patient has signs of volume overload as evidence by a score of ≥ 4 on the EVEREST score Patient with Left Ventricular Ejection Fraction LVEF >15% Patient has compromised response to diuretics NT-proBNP >450 pg/mL if aged <55 years, >900 pg/mL if aged between 55 and 75 years and >1800 pg/mL if aged >75 years Exclusion Criteria: Patient with active DVT or history of DVT Patient has documented or evidence of Renal artery stenosis BMI>35 Kg/m^2 Patient has documented, untreated symptomatic coronary artery disease (CAD) requiring revascularization Patient is in Cardiogenic shock Patient has blood dyscrasia, acute anemia, thrombocytopenia, bleeding diathesis, or coagulopathy Temperature > 38°C, or sepsis, or active systemic infection requiring IV anti-microbial treatment Patient has shown liver cirrhosis or has signs of liver damage

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ADHF patients<br>ADHF patients with compromised response to diuretics treated with Nephronyx system | Device: Nephronyx system (Perfuser)<br>* Temporary deployment of the Nephronyx system (Perfuser)<br>* Other names: The Nephronyx system (Perfuser);|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serious Adverse Events | Device and/or investigational procedure related SAEs | 24 hours post device retrieval | 
| Performance/ Procedural success | Device preforms as planned with no associated device malfunction | procedure day |
Analyzing Clinical Research Participation of Patients With Spinal Cord Injury

Study Overview
=================
Brief Summary
-----------------
The percentages of participants in clinical studies haven't always been perfectly representative of a particular group. This research examines the variables that affect a patient's choice to enroll in, discontinue participation in, or resume participation in a clinical trial for spinal cord injury. It will also try to analyze data from the perspective of different demographic groups to check for recurring trends which might yield insights for the sake of future spinal cord injury research.

Official Title
-----------------
A Review of Clinical Trial Experiences and Trends From Spinal Cord Injury Patients

Conditions
-----------------
Spinal Cord Injuries

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Aged ≥ 18 years old Ability to understand and the willingness to sign a written informed consent document. Diagnosis of spinal cord injury Exclusion Criteria: Is pregnant, breastfeeding or expecting to conceive within the projected duration of the study Has a serious medical or psychiatric illness likely to interfere with participation in this clinical study. Inability to provide written informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of patients who decide to enroll in a spinal cord injury clinical study. |  | 3 months | 
| Number of spinal cord injury study participants who remain in clinical trial until completion. |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Spinal Cord Injuries, spinal cord injury