Validation of a Diagnostic Score for Encephalitis to Assess the Risk of Autoimmune Origin

Study Overview
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Brief Summary
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The investigators wish to test a diagnostic risk score for autoimmune encephalitis in case of encephalitis, previously validated by two American teams, in a retrospective analysis, according to the clinical and paraclinical data available in our database of the Reference Centre for Autoimmune Encephalitis and Paraneoplastic Neurological Syndromes of Professor Honnorat for patients with NMDAr, anti LGi1, anti CASPR2, anti GABAbr and anti GAD antibodies.

Official Title
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Validation of a Diagnostic Score for Encephalitis to Assess the Risk of Autoimmune Origin

Conditions
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Autoimmune Encephalitis, Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody (Disorder)

Intervention / Treatment
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* Other: Clinical score of Granillo and al.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age > 18 years old Patient with a definite auto-immune encephalitis (Graus and al. 2016) Exclusion Criteria: Uncomplete data in acute phase Patient with several antibodies Opposition

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| NMDAr patients<br>Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti NMDAr | Other: Clinical score of Granillo and al.<br>* Compare the performance of the clinical prediction score of confirmed autoimmune encephalitis according to the type of antibody isolated from the CSF.<br>|
| LGI1 patients<br>Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti LGI1 | Other: Clinical score of Granillo and al.<br>* Compare the performance of the clinical prediction score of confirmed autoimmune encephalitis according to the type of antibody isolated from the CSF.<br>|
| CASPR2 patients<br>Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti CASPR2 | Other: Clinical score of Granillo and al.<br>* Compare the performance of the clinical prediction score of confirmed autoimmune encephalitis according to the type of antibody isolated from the CSF.<br>|
| GABAb patients<br>Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti GABAb | Other: Clinical score of Granillo and al.<br>* Compare the performance of the clinical prediction score of confirmed autoimmune encephalitis according to the type of antibody isolated from the CSF.<br>|
| GAD patients<br>Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti GAD | Other: Clinical score of Granillo and al.<br>* Compare the performance of the clinical prediction score of confirmed autoimmune encephalitis according to the type of antibody isolated from the CSF.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Validation of a diagnostic score for encephalitis to assess the risk of autoimmune origin. | Comorbidities assessed by the Charlson score | At baseline | 
| Symptoms in the acute phase |  | At baseline | 
| Mode of onset of disease |  | At baseline | 
| Results of lumbar puncture |  | At baseline | 
| Results of antineuronal antibodies in CSF |  | At baseline | 
| Results of antineuronal antibodies in serum |  | At baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Diagnostic score, auto-immune encephalitis