The Translational Initiative to Map Epigenetics in Aging (TIME-A)

Study Overview
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Brief Summary
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The Translational Initiative to Map Epigenetics in Aging (TIME-A) study aims to advance our understanding of the connections between epigenetics, lifestyle, demographics, and health and aging.

Detailed Description
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TIME-A is a longitudinal research initiative. Anyone who has ever taken an Index test registered through Elysium Health is eligible to participate. Participation involves answering questions that will be administered via a survey format. Research participants' survey responses will be combined with their epigenetic Index data with the primary aim of identifying the contributions of 1) environmental and lifestyle factors, 2) general health, and 3) medical history, on biological age. Exploratory aims include the development of epigenetic signatures that are predictive of health status, and exploring the relationship between epigenetically-derived health phenotypes and biological age. These findings will lay the foundation for personalized health recommendations using Index (including, but not limited to: workout routines, diets, supplement regimens, medications, lifestyle changes).

Official Title
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The Translational Initiative to Map Epigenetics in Aging (TIME-A)

Conditions
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Biological Aging

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All adults aged 18 and above Have registered at least one Index kit via the Elysium Health website Able and willing to provide digital consent to the Research Consent Form, and the TIME-A Research Subject Consent Form Exclusion Criteria: Consent to participate not given

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| TIME-A<br>Group will complete periodic surveys | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of environmental and lifestyle factors on biological age | Univariate and multivariate statistical methods will be used to identify which environmental and lifestyle factors (from TIME-A survey responses) influence biological age. | At baseline and throughout study (approximately every 6 months up to 120 months) | 
| Effect of general health on biological age | Univariate and multivariate statistical methods will be used to identify which general health characteristics (from TIME-A survey responses) influence biological age. | At baseline and throughout study (approximately every 6 months up to 120 months) | 
| Effect of medical history on biological age | Univariate and multivariate statistical methods will be used to identify the impact of medical history (from TIME-A survey responses) on biological age. | At baseline and throughout study (approximately every 6 months up to 120 months) |