Lung Function in Post-COVID-19 Nursing Home Residents

Study Overview
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Brief Summary
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The coronavirus disease 2019 (COVID-19) took a toll in institutionalised older adults, who represent a vulnerable population in European countries. The aim of this study is to identify the predictive factors that worsens lung function in post-COVID nursing home (NH) residents. This is a multicenter case-control study in nursing homes of Osona (Catalonia), where individuals with worsened (cases) and normal (controls) lung function will be studied. The inclusion criteria are: female and male from 65 to 95 years old, preserved cognitive capacity and positive diagnosis of COVID-19 at least 3 months prior. We will assess sociodemographic variables, lung function [spirometry], fatigue [Chalder Fatigue Scale], frailty [Clinical Frailty Scale], and activities of daily living (ADL) [modified Barthel index].

Official Title
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Associated Factors for Impaired Lung Function in Post-COVID Nursing Home Residents

Conditions
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Post-COVID-19 Syndrome

Intervention / Treatment
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* Other: Previous exposure to SARS-CoV-2


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: male and female preserved cognitive function previous positive diagnosis of COVID-19 at a minimum of 3 months to the day of data collection individuals living permanently in a nursing home Exclusion Criteria: individuals in coma or palliative care any contraindication to perform spirometry (severe hypertension, myocardial infarction in the past week, non compensated heart failure, etc).

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Case<br>Individuals with impaired lung function, according to spirometry results (FVC ≤ LLN and FEV1/FVC ≥ LLN). | Other: Previous exposure to SARS-CoV-2<br>* This is an observational study in which no intervention will be applied.<br>|
| Control<br>Individuals with normal lung function | Other: Previous exposure to SARS-CoV-2<br>* This is an observational study in which no intervention will be applied.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lung function | Lung function will be assessed by spirometry. | Through study completion, an average of 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sociodemographic variables | Sociodemographic variables (age, gender, length of institutionalization) will be collected through an interview. | Through study completion, an average of 1 year | 
| Anthropometric variables | Anthropometric variables (weight and height) will be collected by means of a scale and a measuring tape, respectively. | Through study completion, an average of 1 year | 
| Health variables | Health variables (history of comorbidities) will be collected directly in the medical records of each participant. | Through study completion, an average of 1 year | 
| COVID-19 variables | The following variables related to COVID-19 will be collected from the medical records of each participant: diagnostic tests (PCR and serological test), suspicious case (symptoms of cough, fever, difficulty breathing, etc.), previous hospitalization for COVID-19 (yes/no, duration), use of mechanical ventilation during hospitalization (yes/no, duration) and vaccination (yes/no, type). | Through study completion, an average of 1 year | 
| Fatigue | Fatigue levels will be collected using the Chalder Fatigue Scale (CFQ-11) | Through study completion, an average of 1 year | 
| Frailty | Frailty levels will be assessed using the Clinical Frailty Scale (CFS). | Through study completion, an average of 1 year | 
| Dependency levels | Dependency levels will be assessed using the Barthel modified index. | Through study completion, an average of 1 year |