TMD-specific Physiotherapy in hEDS Patients Individuals With Hypermobile Ehlers-Danlos Syndrome

Study Overview
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Brief Summary
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The aim of this study is to analyze the effects of strictly defined physiotherapy in patients temporomandibular dysfunction (TMD) and hypermobile Ehlers-Danlos Syndrome (hEDS). Patients will be clinically examined before starting physiotherapy and fill in the questionnaires. Subsequently, it will be followed up whether changes occur as a result of physiotherapy. This study is a pilot study and is intended to be hypothesis generating in nature. Based on the resulting hypothesis, it will be verified by a study with a control group.

Official Title
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Effects of TMD-specific Physiotherapy in Individuals With Hypermobile Ehlers-Danlos Syndrome

Conditions
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Hypermobile Ehlers-Danlos Syndrome

Intervention / Treatment
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* Procedure: Physiotherapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: written consent to participate in the study confirmed diagnosis of hEDS (based on the diagnostic criteria of the current classification of 2017). pain in the area of the masticatory muscles and/or the temporomandibular joints command of the German language, both spoken and written Exclusion Criteria: currently undergoing TMD-specific treatment (physiotherapy, pain therapy masticatory muscles and/or temporomandibular joint, orthopedic treatment, osteopathic treatment). persons diagnosed with depression, anxiety or stress disorder taking opiates pregnant women minors persons with mental disability persons who are not able to speak and write the German language persons with legal representatives

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Physiotherapy<br>Using a strictly defined physiotherapy protocol, the effects on temporomandibular dysfunctions are studied. | Procedure: Physiotherapy<br>* Various physiotherapeutic techniques are used in three defined sessions. Before the first session, a dental examination is performed and a clinical functional status is obtained to assess the extent of temporomandibular dysfunction. The results are recorded on validated questionnaires.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction of temporomandibular pain | The German version of the Graded chronic pain scale is used to measure the level of pain. | Up to 3 months after the last physiotherapy intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effects on psychosocial impairment | The German version of the Depression Anxiety Stress Scale is used to assess psychosocial impairment | Up to 3 months after the last physiotherapy intervention | 
| Effects on oral health-related quality of life (OHRQoL) | The German version of the Oral Health Impact Profile (OHIP-G5) is used to assess OHRQoL | Up to 3 months after the last physiotherapy intervention |