linjc16/ctgov huggingface dataset:
Neoadjuvant Dose-dense Chemotherapy for HR+/HER2- Breast Cancer Patients With High Proliferation Index

Study Overview
=================
Brief Summary
-----------------
Studies have shown that dose-dense chemotherapy reduces the risk of recurrence and death of breast cancer patients comparing with standard-schedule chemotherapy. But some research data indicate that HR+/HER2- breast cancer patients benefit from dose-dense chemotherapy while some have negative results. How to identify HR+/HER2 breast cancer patients who are more likely to benefit from dose-dense chemotherapy is strongly necessary. Ki67 is a marker reflecting the proliferation of tumor cells. Breast cancer patients with high Ki67 are more likely to benefit from dose-dense chemotherapy. The purpose of this project is to investigate the efficacy and safety of neoadjuvant dose-dense chemotherapy for HR+/HER2- breast cancer patients with high proliferation index. At the same time, we will explore biomarkers, such as MammaPrint and BluePrint, to further identify patients who benefit more from neoadjuvant dose-dense chemotherapy.

Official Title
-----------------
Neoadjuvant Dose-dense Chemotherapy for HR+/HER2- Breast Cancer Patients With High Proliferation Index

Conditions
-----------------
Breast Cancer

Intervention / Treatment
-----------------
* Drug: dose-dense nab-paclitaxel followed by EC


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Females with age of 18 to 70 years old. Newly diagnosed breast cancer patients. Planned neoadjuvant chemotherapy. Hormone receptor status: Estrogen receptor (ER)-positive or Progesterone Receptor (PR)- positive. HER2/neu-negative. Ki67≥30%. Clinical stage IIB-IIIC. Informed consent form understood and signed. Patient agrees to all follow-up visits. Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1. Women of childbearing potential must have a negative serum pregnancy test. Exclusion Criteria: Metastatic disease Pregnancy. Nursing mothers. Active or uncontrolled infection. Presence of another malignancies. Granulocyte count < 1.5*10^9/L. Platelet count < 100*10^9/L. Hemoglobin < 90g/L. Serum Creatinine more than 1.5 upper limit. AST and ALT more than 2.5 upper limit. LVEF< 50%.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: dose-dense arm<br> | Drug: dose-dense nab-paclitaxel followed by EC<br>* dose-dense nab-paclitaxel followed by EC<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| RCB | Residual Cancer Burden | 7 days |
Treatment Of Unstable Trochanteric Fracture: A Comparative Study Between DHS And DHS With Trochanteric Stabilization Plate

Study Overview
=================
Brief Summary
-----------------
compare the results in treatment of unstable trochanteric fracture by using DHS and DHS with Trochanteric Stabilizing plate as regard shaft medialization.neck shaft angle measurment and shaft migration

Official Title
-----------------
Treatment Of Unstable Trochanteric Fracture: A Comparative Study Between DHS And DHS With Trochanteric Stabilization Plate

Conditions
-----------------
Trochanteric Fractures

Intervention / Treatment
-----------------
* Procedure: dynamic hip screw


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: pateints with comminution of medial femoral cortex and loss of continuity of lesser trochanter Exclusion Criteria: stable trochanteric fracture subtrochanteric extension reverse oblique trochanteric fracture

Ages Eligible for Study
-----------------
Minimum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: DHS<br>patients with trochanteric fracture treated with DHS | Procedure: dynamic hip screw<br>* using dynamic hip screw in treatment of trochanteric fracture and dynamic hip screw with trochanteric stabilizing plate<br>|
| Active Comparator: DHS with Trochanteric stabilizing plate<br>patients with trochanteric fracture treated with DHS with trochanteric stabilizing plate | Procedure: dynamic hip screw<br>* using dynamic hip screw in treatment of trochanteric fracture and dynamic hip screw with trochanteric stabilizing plate<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| neck shaft angle measurment .Harris hip score | measurment of neck shaft angle between two groups | 6 months |
Hürthle Cell Carcinoma and Follicular Thyroid Carcinoma

Study Overview
=================
Brief Summary
-----------------
The goal of this retrospective study is to evaluate in patients with HCC and FTC who underwent lobectomy. The main questions it aims to answer are: The necessity of completion thyroidectomy based on the clinicopathological characteristics Prognosis Participants underwent thyroid lobectomy Researchers compared HCC and FTC groups to see the prognosis after lobectomy.

Detailed Description
-----------------
Background The prognosis of Hürthle cell carcinoma (HCC) and follicular thyroid carcinoma (FTC) is poorly understood. These types of cancers are usually confirmed after diagnostic lobectomy. We aimed to evaluate the clinicopathological characteristics and prognoses of patients with HCC and FTC who did not undergo completion thyroidectomy. Materials and Methods We screened 221 patients diagnosed with FTC or HCC after thyroid lobectomy at Yonsei Severance Hospital between January 2000 and December 2020. After excluding patients who underwent complete thyroidectomy, 184 patients with FTC and 37 patients with HCC were included.

Official Title
-----------------
Clinicopathological Characteristics of Hürthle Cell Carcinoma and Follicular Thyroid Carcinoma Without Completion Thyroidectomy

Conditions
-----------------
Huerthle Cell Carcinoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Follicular thyroid carcinoma Hurthle cell carcinoma Lobectomy Exclusion Criteria: Completion thyroidectomy Total thyroidectomy
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| FTC<br>Follicular thyroid carcinoma | |
| HCC<br>Hurthle cell carcinoma | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disease-free survival (DFS) | a comparison of disease-free survival (DFS) between FTC and HCC groups | From January 2000 to March 2023 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| TNM stage | a comparison of TNM stage between FTC and HCC groups | From January 2000 to March 2023 |
Evaluation of the Vulnerable Carotid Atherosclerotic Plaque: A Clinical Multicenter Study

Study Overview
=================
Brief Summary
-----------------
Evaluation of carotid plaque vulnerability based on ultrasound imaging features， proteomics and metabolomics: a clinical multicenter study

Detailed Description
-----------------
Carotid artery plaque tissue specimen for proteomics. Blood were collect for metabolomics.

Official Title
-----------------
Evaluation of the Vulnerable Carotid Atherosclerotic Plaque: A Clinical Multicenter Study

Conditions
-----------------
Ultrasound

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who meet the CEA surgical indications; Age>18 years old; Patients who sign informed consent forms Exclusion Criteria: Those with severe calcification of plaques and obvious acoustic shadows, and poor image quality; Contraindications to ultrasound contrast, such as those who are allergic to contrast agents; Intracardiac right to left shunt;
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Stable Carotid Atherosclerotic Plaques<br> | |
| Unstable Carotid Atherosclerotic Plaques<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ultrasound | B mode | 2023.05 |
Potassium Nitrate in Polycarboxylate as a Direct Pulp Capping

Study Overview
=================
Brief Summary
-----------------
The study aimed to compare potassium nitrate in polycarboxylate cement to mineral trioxide aggregate as a direct pulp capping material of young permanent teeth in patients from 7 to 10 ears

Official Title
-----------------
Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate as a Direct Pulp Capping in Young Permanent Molars

Conditions
-----------------
Pulp Disease, Dental

Intervention / Treatment
-----------------
* Other: potassium nitrate in polycarboxilate cement


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 7-10 years of children Healthy children classified as ASA I or II Asymptomatic vital immature mandibular first molar with extensive and deep caries Signs and symptoms of reversible pulpitis Exclusion Criteria: Necrotic teeth or teeth with irreversible pulpitis Medically compromised children

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 10 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: potassium nitrate in polycarboxilate cement<br> | Other: potassium nitrate in polycarboxilate cement<br>* 5% potassium nitrate in polycarboxylate; pre-weighed 95 mg zinc oxide powder and 5mg of KNO3 will be placed on a glass slab followed by mixing by polyacrylic acid (liquid) in a 1:1 P/L ratio<br>|
| Active Comparator: Mineral Trioxide Aggregate<br> | Other: potassium nitrate in polycarboxilate cement<br>* 5% potassium nitrate in polycarboxylate; pre-weighed 95 mg zinc oxide powder and 5mg of KNO3 will be placed on a glass slab followed by mixing by polyacrylic acid (liquid) in a 1:1 P/L ratio<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| clinical success rate | Absence of pain, sensitivity to percussion, fistula or sinus tract, mobility | 24 months | 
| Radiographic success rate | Absence of periapical radiolucency, internal root resorption, external root resorption | 24 months |
Efficacy and Safety of DKB-119 in Patients in Crow's Feet

Study Overview
=================
Brief Summary
-----------------
To prove the non-inferiority of DKB-119 by evaluating the injecting efficacy and safety DKB-119 and control for patients in crow's feet

Detailed Description
-----------------
A single center, randomized, subject and evaluator blinded, split-face, pivotal clinical trial

Official Title
-----------------
A Single Center, Randomized, Subject and Evaluator Blinded, Split-face, Pivotal Clinical Trial to Evaluate the Efficacy and Safety of DKB-119 in Crow's Feet

Conditions
-----------------
Crow's Feet

Intervention / Treatment
-----------------
* Device: DKB-119


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Those who are over 19 under 70 ages. Those who score 2 or more in the LCL severity evaluation. Those who have visually symmetrical crow's feet on both sides. Etc. Exclusion Criteria: Pregnancy and lactating women. Etc.

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: DKB-119<br>Injecting to one side crow's feet | Device: DKB-119<br>* Experimental and Acitve Comparator are applied 4 times to each of crow's feet on both sides of the subject.<br>|
| Active Comparator: Control<br>Injecting to one side crow's feet | Device: DKB-119<br>* Experimental and Acitve Comparator are applied 4 times to each of crow's feet on both sides of the subject.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Crow's feet | Difference in improvement rate (percentage) | 18 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Crow's feet | Difference in improvement rate (percentage) | 8, 10 weeks | 
| LCL(Lateral Canthal Line) Severity | Difference in improvement rate (percentage) | 8, 10, 18 weeks | 
| GAIS(Global Aesthetic Improvement Scale) | GAIS 5 point scale (minimum -1 to maximum 3 points, The higher the score, the better the value) | 8, 10, 18 weeks |
Marital Rape:Knowledge, Attitudes and Prevalence in Asample of Married Women in Sohag Governorate

Study Overview
=================
Brief Summary
-----------------
this study aims at estimation of prevalence of marital rape attitudes and knowledge towards it using semi structured questionnaire

Detailed Description
-----------------
this study trying to estimate knowledge of married women in sohag about marital rape attitudes towards it the size of the problem psychological , mental ,physical health consequences if the problem deserve criminalization

Official Title
-----------------
Marital Rape:Knowledge, Attitudes and Prevalence in Asample of Married Women in Sohag Governorate

Conditions
-----------------
Marital Rape Knowledge ,Attitudes and Prevalence

Intervention / Treatment
-----------------
* Other: semi-structures questionaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: married or previously married females Exclusion Criteria: mentally disabled or who with low IQ

Ages Eligible for Study
-----------------
Minimum Age: 15 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Female

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: semi-structures questionaire|semi -structured questionnaire prepared by the researcher collect sociodemographic data , awareness ,attitudes about marital rape and health consequences|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| attitudes to marital rape questionnaire | married waomen know about marital rape or not | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of marital rape questionnaire | size of the proplem | 6 months |
End-Expiratory Lung Volume in Children Awakening From Propofol Anesthesia

Study Overview
=================
Brief Summary
-----------------
The goal of this pilot randomized clinical trial is to test the effects of high flow nasal oxygen and head elevation during awakening from propofol anesthesia in pediatric patients undergoing airway surgery. The main question[s] it aims to answer are: High flow oxygen can decrease the occurence of atelectasis during awakening from propofol anesthesia in pediatric patients? Head elevation can decrease the occurence of atelectasis during awakening from propofol anesthesia in pediatric patients? Researchers will compare high flow oxygen vs low flow oxygen group to see if the use of high flow oxygen decrease the occurence of atelectasis during awakening from propofol anesthesia. And in each group, the patients will be assigned to supine position vs head elevation position to compare the effects of head elevation during awakening from propofol anesthesia.

Official Title
-----------------
The Effects of High-Flow Nasal Cannula and Body Position On Atelectasis Using Electric Impedance Tomography in Children Awakening From Propofol Anesthesia: A Pilot Randomized Controlled Trial.

Conditions
-----------------
Atelectasis, Postoperative Pulmonary

Intervention / Treatment
-----------------
* Other: Head elevation_H
* Other: Supine_H
* Other: Head elevation_L
* Other: Supine_L


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pediatric patients undergoing airway surgery with high flow nasal oxygen Exclusion Criteria: Loss of spontaneous ventilation during surgery less than 1 months cyanotic patients

Ages Eligible for Study
-----------------
Minimum Age: 1 Month
Maximum Age: 7 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: high flow oxygen<br>Oxygen supply (2L/kg/min.) during awakening from propofol anesthesia | Other: Head elevation_H<br>* High flow_Head-elevation<br>Other: Supine_H<br>* High flow_Supine<br>|
| Active Comparator: Low flow oxygen<br>Oxygen supply (0.3L/kg/min.) during awakening from propofol anesthesia | Other: Head elevation_L<br>* Low flow_head elevation<br>Other: Supine_L<br>* Low flow_supine<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in Electric Impedance Tomography parameter |  | from induction of anesthesia to end of operation, about 3 hours |
Evaluation of Preoperative Risk Factors in Children

Study Overview
=================
Brief Summary
-----------------
The investigators aimed to make a more advanced risk assessment in predicting preoperative intensive care unit admission in pediatric patients. The investigators aimed to better define the pediatric patient population and identify preoperative risk factors in detail in order to reduce perioperative complications.

Detailed Description
-----------------
The aim of this study was to evaluate preoperative risk factors and determine their efficacy in predicting ICU admission after emergency or elective surgery in pediatric patients of all age groups. To achieve this aim, data such as gender, age, height, weight, history of prematurity, post-conceptional week, ASA PS score, accompanying systemic diseases, history of previous anesthesia, history of emergency or elective surgery, tumor surgery, chemotherapy and radiotherapy, surgical risk classification, difficult airway will be collected.

Official Title
-----------------
Evaluation of Preoperative Risk Factors in Prediction of ICU Admission in Children, An Observational Prospective Study

Conditions
-----------------
Anesthesia Morbidity, Preterm Birth, Difficult or Failed Intubation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children under the age of 18 who will have an operation in the pediatric surgery operating room. Exclusion Criteria: Children who are scheduled for surgery in pediatric surgery room but are hospitalized in the intensive care unit.(Children admitted directly from the intensive care units to the operating rooms)

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ASA-PS | The American Society of Anesthesiologists (ASA) physical status preoperative risk assesttment | Preoperative visit period ( 20 minutes) | 
| Postoperative PICU admission | Number of participants of Postoperative Pediatric Intensive Care Unit admission | postoperative follow-up ( in 72 hours) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ASA-PS, surgical risk, risk assessment, preoperative, prediction of icu admission
Assessing the Experience of Patients Undergoing Follicular Lymphoma Clinical Research

Study Overview
=================
Brief Summary
-----------------
Historically, participation in medical studies is highly skewed towards particular demographic groups of people. This research will invite several participants to gather a wide range of information on clinical trial experiences for follicular lymphoma patients. The aim of the study is to identify the factors that limit the ability of a person to enroll in, as well as complete a clinical trial for treatment of follicular lymphoma. The data collected from this study will help improve future outcomes for all follicular lymphoma patients as well as those in under-represented demographic groups.

Official Title
-----------------
Unveiling Follicular Lymphoma Clinical Trials: Analyzing Patient Engagement Patterns and Participation Trends

Conditions
-----------------
Follicular Lymphoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Participant must be 18 years of age or older Patient has been diagnosed with follicular lymphoma Patient has access to a home internet connection in order to provide regular updates through the course of the study Exclusion Criteria: Women of childbearing potential without a negative pregnancy test; or women who are lactating. Inability to provide written informed consent Patients receiving any other investigational agents

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients who decide to enroll in a follicular lymphoma clinical research |  | 3 months | 
| Rate of patients who remain in a follicular lymphoma medical study to trial completion |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
follicular lymphoma