Effects of COP Exercise and HIIT on Vascular Health in Young Overweight Females

Study Overview
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Brief Summary
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The goal of this study is to determine the effects of high-intensity interval training and crossover point exercise training on vascular health in young overweight women.

Detailed Description
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In recent years, improving cardiovascular health through exercise has become a popular research question, however, it is not clear which intensity and modes of exercise bring more benefits. Crossover point(COP) intensity has great medical potential as a personalized exercise intensity that is based on substrate utilization mode, especially in overweight and obese people.On the other hand, several studies have demonstrated that HIIT is an effective method in improving vascular endothelial dysfunction. During our study, we evaluated the vascular health changes in young overweight women who received either COP exercise or HIIT exercise for 10 weeks.

Official Title
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Effects of Crossover Point Exercise and High-intensity Interval Training on Vascular Health in Young Overweight Females

Conditions
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Vascular Diseases

Intervention / Treatment
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* Behavioral: high-intensity interval training (HIIT)
* Behavioral: crossover point(COP) exercise training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Female, 18-30 years old Body mass index (BMI) < 28 kg/m2 and ≥ 24 kg/m2 No exercise habit, and no recent new exercise plan No contraindications to exercise Exclusion Criteria: Participates had an orthopedic or other condition that limited participation in daily exercise Participates had a history of myocardial infarction, stroke, diabetes mellitus, chronic respiratory disease or cancer Participates had smoking or alcohol behavior

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: HIIT group<br> | Behavioral: high-intensity interval training (HIIT)<br>* Participants in both the COP and HIIT groups underwent 30 sessions of exercise performed over 10 weeks. The training sessions in the HIIT group involved five high-intensity intervals of 4 minutes each (running or walking on a treadmill) at 85% VO2max interspersed with 3 minutes of low-intensity walking.<br>|
| Experimental: COP group<br> | Behavioral: crossover point(COP) exercise training<br>* Participants in both the COP and HIIT groups underwent 30 sessions of exercise performed over 10 weeks. The COP exercise training sessions involved 45 minutes of continuous exercise at the COP on a treadmill.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| brachial-ankle pulse wave velocity (baPWV) | The change of baPWV before and after intervention | 10 weeks | 
| blood pressure | The change of blood pressure before and after intervention | 10 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Interleukin 6 (IL-6) | The change of IL-6 level before and after intervention | 10 weeks | 
| Homocysteine (HCY) | The change of HCY level before and after intervention | 10 weeks |