Developing and Optimizing Transcranial Magnetic Stimulation for Motor Rehabilitation

Study Overview
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Brief Summary
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This study aims to evaluate three different transcranial magnetic stimulation protocols and their impact on motor system neurophysiology and skill learning.

Detailed Description
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Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that induces long-term changes in connections between neuronal networks. This and the ability to activate the whole motor system allows the use of TMS to facilitate motor recovery. The motor system has different excitatory states associated with ongoing mu oscillation. Here, the investigators will monitor brain mu oscillations in real-time non-invasively using electroencephalography and modulate the function of the motor system. The investigators will test the impact of three different TMS protocols on motor system neurophysiology and skill learning. These data will provide novel understanding needed to improve TMS approaches for individuals requiring motor rehabilitation.

Official Title
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Developing and Optimizing Transcranial Magnetic Stimulation for Motor Rehabilitation

Conditions
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Motor Cortex, Motor Skills

Intervention / Treatment
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* Device: Transcranial Magnetic Stimulation (TMS)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-40 years old Able to read, understand, and sign the informed consent in English Right-handed Exclusion Criteria: A sensory or physical impairment History of epilepsy or seizures in the family Non-removable metal or electronics (e.g., a cochlear implant, cardiac pacemaker, or implanted electronic devices) in your head or body A head injury with loss of consciousness Diagnosis of psychiatric or neurological disorder Skin defects or active infections on the scalp or hands Pregnancy or breastfeeding

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Single-pulse TMS over the primary motor cortex<br>We will administer single-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task. | Device: Transcranial Magnetic Stimulation (TMS)<br>* Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.<br>|
| Experimental: Paired-pulse TMS over the primary motor cortex<br>We will administer paired-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task. | Device: Transcranial Magnetic Stimulation (TMS)<br>* Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.<br>|
| Sham Comparator: Sham TMS over the primary motor cortex<br>We will administer sham TMS to the primary motor cortex while measuring motor responses and before a skill-learning task. | Device: Transcranial Magnetic Stimulation (TMS)<br>* Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effect of TMS on motor evoked potentials | Amplitude of the motor evoked potentials in millivolts. | Up to 1 second after TMS | 
| Skill learning accuracy | Skill learning accuracy as the total number of correct responses. | Up to 12 minutes | 
| Skill learning speed | Skill learning speed in seconds. | Up to 12 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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TMS, Motor system, Healthy