Assessment of Different Orthodontic Tooth Movements Assisted With Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin

Study Overview
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Brief Summary
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The present prospective clinical study will be undertaken for assessment of the effect of application of Injectable plasma-rich fibrin versus Low-Level Laser Therapy onthe rate of different orthodontic tooth movements,

Detailed Description
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The present prospective clinical study will be undertaken for assessment of the effect of application of Inject able plasma-rich fibrin versus Low-Level Laser Therapy on the rate of different orthodontic tooth movements, namely: canine retraction, mandibular incisors leveling and alignment, maxillary molar distalization and maxillary incisor intrusion.

Official Title
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Assessment of Different Orthodontic Tooth Movements Assisted With Low-level Laser Therapy vs. Injectable Plasma-rich Fibrin: A Comparative Clinical Investigation

Conditions
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Injectable Plasma-rich Fibrin Versus Low-Level Laser Therapy on Othodontic Movement

Intervention / Treatment
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* Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: A- leveling and alignment Eligibility criteria Complete permanent dentition (third molars not included). Moderate mandibular anterior crowding (with Little's irregularity index score greater than 4 mm) who required nonextraction approach in the mandibular arch. No tooth size, shape or root abnormalities visible on patient's radiographic records. No spaces in the mandibular arch. No blocked out tooth that did not allow for placement of the bracket at the initial bonding appointment. No required management with interproximal stripping, intermaxillary elastics, open NiTi springs, and removable or extra-oral devices. Maxillary molar distalization Inclusion criteria: 1. Age ranges from 14 to 17 years. 2. Bilateral Class II molar relationship. 3. Skeletal Class I or mild Class II relationship. 4. Normal or decreased vertical height. 5. No posterior crowding or spaces. 6. Fully erupted maxillary first and second molars. 7. Congenitally missing or extracted third molars. 8. Good oral hygiene. 9. Absence of any periodontal disease and alveolar bone loss. 10. Absence of medications that may inhibit orthodontic movement Lower incisor leveling and alignment Inclusion criteria Complete permanent dentition (third molars not included); Moderate mandibular anterior crowding (with little's irregularity index score greater than 4 mm) who required non-extraction approach in the mandibular arch; No tooth size, shape or root abnormalities visible on the patient's radiographic records; No spaces in the mandibular arch; No blocked out tooth that did not allow for placement of the bracket at the initial bonding appointment; 6. No required management with interproximal stripping, inter-maxillary elastics, open NiTi springs, and removable or extra-oral devices. Canine retraction Eligibility criteria Age, 15 to 25 years; Class ii division 1 malocclusion with mild or no crowding; No previous orthodontic treatment; No systemic disease that might have affected bone formation or density, such as osteoporosis, hyperparathyroidism, or vitamin d deficiency; Adequate oral hygiene; Probing depth values not exceeding 3 mm across the Entire dentition; Adequate thickness of the attached gingiva (1-2 mm); No radiographic evidence of bone loss Exclusion Criteria:Exclusion criteria: Patients who required surgery to correct skeletal discrepancies. Patients with congenital dentoskeletal disorders. Missed or mutilated teeth in maxillary arch. Patients with poor oral hygiene and/or periodontally compromised patients Severe dental crowding that necessitates an extraction approach 2. Abnormal anteroposterior and vertical relationships; 3. Patients with cleft lip and palate, anomalies, and syndromes; 4. Previous orthodontic 5. Treatment; 6. Regular medications intake that could interfere with otm. -

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 22 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Factorial Assignment
Interventional Model Description: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: i-PRF side: canine retraction<br>application of i-PRF with translation of maxillary canine that will be performed on intervention sides according to a standardized protocol | Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin<br>* laser and platelet rich fibrin<br>|
| No Intervention: i-prf side control side<br>i-PRF side:canine retraction control side | |
| Experimental: LLLT side canine retraction<br>translation of maxillary canine that will be performed with LLLT application according to a standardized protocol | Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin<br>* laser and platelet rich fibrin<br>|
| No Intervention: LLLT side canine retraction control side<br>LLLT side canine retraction control side wihout intervention | |
| Experimental: I-PRF groupMolar distalization group inrervention side<br>Idistalization assisted with Injectable platelet-rich fibrin (i-PRF) according to a standardized protocol | Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin<br>* laser and platelet rich fibrin<br>|
| No Intervention: I-PRF groupMolar distalization group control side<br>distalization without i-PRF intervention | |
| Experimental: LLLT group: distalization intervntion side<br>distalization will be commenced with application of LLLT according to a standardized protocol | Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin<br>* laser and platelet rich fibrin<br>|
| No Intervention: LLLT group: distalization control side<br>distalization will be commenced without application of LLLT according to a standardized protocol | |
| Experimental: i-PRF group: leveling and alignment<br>leveling and alignment assisted with Injectable platelet-rich fibrin (i-PRF) according to a standardized protocol | Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin<br>* laser and platelet rich fibrin<br>|
| Experimental: LLLT group: leveling and alignment<br>leveling and alignment be commenced with application of LLLT according to a standardized protocol | Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin<br>* laser and platelet rich fibrin<br>|
| No Intervention: leveling and alignment without intervention<br>leveling and alignment without intervention | |
| Experimental: I-PRF group: Intrusion<br>intrusion assisted with Injectable platelet-rich fibrin (i-PRF) according to a standardized protocol | Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin<br>* laser and platelet rich fibrin<br>|
| Experimental: LLLT group: Intrusion<br>intrusion assisted with application of LLLT according to a standardized protocol | Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin<br>* laser and platelet rich fibrin<br>|
| No Intervention: intrusion control group<br>intrusion without intervention | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| assessment of the effect of application of Injectable plasma-rich fibrin versus Low-Level Laser Therapy on the accelration rate of different orthodontic tooth movements by millimeter |  | 6 months |