Clinical Study of Angong Niuhuang Pill and Acupuncture on PSCI Angong Niuhuang Pill Combined With Supervised Pulse Music Electroacupuncture on Cognitive Impairment After Ischemic Stroke

Study Overview
=================
Brief Summary
-----------------
Post stroke cognitive impairment (PSCI) refers to the attainment of cognitive impairment after the clinical event of stroke A range of syndromes that impede diagnostic criteria. Epidemiologically, PSCI is one of the common complications in stroke patients

Detailed Description
-----------------
(1) Clinical scale data of cognitive function, daily living ability of PSCI patients integrated with the research of this project using uterine Niu Huang pill combined with examined pulse music electroacupuncture For analysis, the efficacy of PSCI patients was observed; (2) In depth studies on auditory event-related potentials of PSCI treated by uterine Niu Huang pill combined with examined pulse music electroacupuncture The changes of serum related nerve growth factor and the relationship between each other in order to enrich / fill our province's research results in this field; (3) In key academic journals 1 high level scientific research paper published.

Official Title
-----------------
Efficacy Evaluation and Evaluation of Peripheral Neuroprotective Mechanism of Amgong Niuhuang Pill Combined With Supervised Pulse Music Electroacupuncture on Cognitive Impairment After Ischemic Stroke

Conditions
-----------------
Post-stroke Cognitive Impairment

Intervention / Treatment
-----------------
* Drug: Angong Niuhuang Pill


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: (1) All were the first stroke, confirmed by head computed tomography (CT) or magnetic resonance imaging (MRI), with vital signs stable; (2) Those who are conscious and can cooperate with relevant treatment; (3) Montreal Cognitive Assessment Scale (MoCA) score ≤ 24 points; （4） The course of disease is more than 1 month, and the patient is 40-70 years old. Exclusion Criteria: (1) People with cognitive impairment before onset; (2) There are contraindications of Angong Niuhuang Pill or electroacupuncture treatment; (3) Complicated with dysfunction of heart, liver, kidney and other important organs; (4) Previous history of cerebral hemorrhage, epilepsy, brain injury, etc; (5) Before onset Have a history of alcohol and drug dependence; (6) The condition worsens, and new hemorrhagic or infarcted foci appear. -

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Angong Niuhuang Pill Group<br>Take half an Angong Niuhuang pill every day for 4 weeks | Drug: Angong Niuhuang Pill<br>* Take Angong Niuhuang pill half a pill/day； Angong Niuhuang pill combined with music scalp acupuncture group These operations last for 4 weeks<br>* Other names: Angong Niuhuang pill combined with music scalp acupuncture group;|
| Experimental: Angong Niuhuang pill combined with music electroacupuncture group<br>Take half an Angong Niuhuang pill every day for 4 weeks and Daily music scalp acupuncture treatment | Drug: Angong Niuhuang Pill<br>* Take Angong Niuhuang pill half a pill/day； Angong Niuhuang pill combined with music scalp acupuncture group These operations last for 4 weeks<br>* Other names: Angong Niuhuang pill combined with music scalp acupuncture group;|
| No Intervention: General control group<br>no intervention | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Simple intelligence state examination scale | MMSE | up to 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Post-stroke cognitive impairment;acupuncture