Effectiveness of Standard Therapy of Acne Vulgaris

Study Overview
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Brief Summary
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This study was to evaluate the effectiveness of standard therapy for acne vulgaris (AV) based on the clinical practice guidelines (CPG) in Indonesia. The main questions it aims to answer were: How is the clinical characteristics of patients with AV in dr.Cipto Mangunkusumo Hospital? How is the effectiveness of standard therapy for AV based on the CPG in Indonesia in reducing the number of non-inflammatory, inflammatory, and total lesions and degree of acne severity? The clinical pratice guideline (CPG) used for analysis was CPG by dr.Cipto Mangunkusumo Hospital 2017 in line with the date of patient visit. Data of 724 patients with AV in dr.Cipto Mangunkusumo Hospital as recorded in the medical records were assessed for eligibility. Data of 3-month-follow-up data of included subjects were collected and analyzed.

Detailed Description
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Objective: To evaluate the effectiveness of standard therapy for acne vulgaris (AV) based on the guidelines in Indonesia Design: An analytical retrospective observational study conducted from April 2023 through July 2023 using medical records of new acne patients between 2017 to 2019 from Dr. Cipto Mangunkusumo National Central General Hospital. A total sample of patients with AV who received standard therapy for acne vulgaris based on the guideline by Dr.Cipto Mangunkusumo Hospital in 2017 and not associated with systemic diseases or drugs were included. Patients were classified into mild, moderate, or severe acne using Lehmann grading system. Primary outcomes were changes in the number of non-inflammatory, inflammatory, and total lesions, and the proportion of acne severity after 3 months of therapy.

Official Title
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Effectiveness of Standard Therapy of Acne Vulgaris Based on Clinical Practice Guidelines (CPG) in Indonesia

Conditions
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Acne Vulgaris

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: New patients with acne vulgaris in the year 2017 to 2019 Complete medical record data of 3-month follow-up, including data of: name, medical record number, sex, age, job, level of education, visit date, number of non-inflammatory, inflammatory, and total acne lesions, diagnosis of acne vulgaris based on Lehmann grading system Acne treatment based on clinical practice guideline by dr.Cipto Mangunkusumo Hospital 2017 Exclusion Criteria: Follow-up data less than 3 times in 3 months Incomplete medical record AV diagnosis without data on severity History of systemic diseases associated with acne such as polycystic ovarian syndrome and Cushing syndrome History of allergy with one or more standard acne therapy based on the clinical practice guideline Received acne therapy not aligned with clinical practice guideline by dr.Cipto Mangunkusumo Hospital
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| General<br>This research is an observational study. There was no control and experimental group. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in non-inflammatory acne lesion count | Change in the sum of the number of open and closed comedones | week-12 | 
| Change in inflammatory acne lesion count | Change in the sum of the number of papules, pustules, nodes, and cysts | week-12 | 
| Change in total acne lesioncount | Change in the sums of the number of non-inflammatory and inflammatory lesions | week-12 | 
| Change in acne severity | Change in the acne severity based on Lehmann grading system (2002), which classified acne into mild, moderate, and severe | week-12 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acne vulgaris, clinical practice guideline, Indonesia, effectiveness, therapy