Effects Of Caffeine On Cognitive Performance

Study Overview
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Brief Summary
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Caffeine is a potent central nervous system stimulant that increases the activity in the prefrontal cortex and can improve cognitive skills. An improvement in these cognitive skills can lead to further benefits in athletic performance. Therefore, it is necessary to clarify the dose-response of caffeine on cognitive performance.The aim of this research will be to determine the effects of different doses of caffeine on sport-related cognitive aspects.

Detailed Description
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The investigators will require healthy, physically active young adults to complete three trials under the conditions: a) placebo, b) 3 mg/kg, or c) 6 mg/kg body mass of caffeine. In each trial, different cognitive abilities will be assessed using the following test batteries: reaction time (DynavisionTM D2), anticipation (Bassin Anticipation Timer), sustained attention (Go/No-Go and Eriksen Flanker Test) and memory tests. In addition, side effects and the perceived sensation index will be recorded 24 h after each test.

Official Title
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Effects Of Different Doses Of Caffeine On Cognitive Performance In Healthy Physically Active Individuals

Conditions
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Caffeine

Intervention / Treatment
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* Dietary Supplement: PLACEBO
* Dietary Supplement: 3 mg/kg of caffeine
* Dietary Supplement: 6 mg/kg of caffeine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Physically active individuals ( >150 min/week moderate physical activity or >75 min/week vigorous physical activity) Individuals without serious and undiagnosed health problems. Exclusion Criteria: Individuals with color blindness. Regular caffeine consumers (>3 cups of coffee/day).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: PLACEBO<br>placebo (0 mg/kg of body mass of caffeine). The capsule will be filled with 3 mg/kg of body mass of cellulose. | Dietary Supplement: PLACEBO<br>* 3 mg/kg of cellulose (0 mg/kg of caffeine)<br>|
| Experimental: 3mg/kg<br>3 mg/kg of body mass of caffeine (99% caffeine, Bulkpowders, United Kingdom). | Dietary Supplement: 3 mg/kg of caffeine<br>* Ingestion of 3 mg/kg of body mass of caffeine<br>|
| Experimental: 6mg/kg<br>6 mg/kg of body mass of caffeine (99% caffeine, Bulkpowders, United Kingdom). | Dietary Supplement: 6 mg/kg of caffeine<br>* Ingestion of 6 mg/kg of body mass of caffeine<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reaction Time | Reaction time (in seconds) shall be assessed with the Dynavision™ D2 Visomotor Device using the Reaction Time Test. In this test the fastest visual, motor and physical reaction time will be measured. | 10 minutes | 
| Anticipation | Visual acuity related to hand-eye coordination and anticipation will be assessed using the Bassin Anticipation Timer instrument. The best anticipation time (in seconds) of each condition (5, 10 and 15 mph) will be taken. | 5 minutes | 
| Sustained attention | The ability of maintaining the attention and inhibiting an appropriate response will be measured by Go/No-Go Test [fastest, slowest, and average response time (in seconds), and successful attempts (percentage; %)] and Eriksen Flanker Test [congruent and incongruent reaction time (in seconds)]. | 10 minutes | 
| Memory | To study the modulation of memory storage processes, three 20-item word lists were created. Each word in the list will be presented for 5 s. This will be followed by a 100 s memory consolidation interval, after which there will be a 120 s period in which as many words as the participants can remember will be written down (First time). After 15 min, participants will perform a recall task (Second time) in which they will have to rewrite all the words they remember at that time. | 20 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ergogenic aid, sport performance, reaction time, anticipation, attention, memory