Comparison of Multiple Exercise Trainings in Chronic Respiratory Disease

Study Overview
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Brief Summary
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The present study aims to investigate the effect of different exercise training in patients with chronic respiratory disease.

Detailed Description
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Background： Chronic respiratory and chronic obstructive pulmonary disease is the one of the major causes of global morbidity and mortality. Patients with chronic respiratory disease often experience exercise limitation and physical inactivity due to muscular weakness and severe dyspnea. Symptoms of COPD may contribute to activity restriction, deconditioning, and exercise intolerance. Pulmonary rehabilitation has been demonstrated to improve clinical outcomes and exercise capacity in patients with chronic respiratory disease. However, the optimal exercise training modality is remaining unclear. Study Design： This is a one-year, single-centre, prospective randomized controlled trial Methods： The investigators expected a total of 60 participants were be enrolled, then randomly assigned into three groups (control group, experimental-1, and experimental-2). All participants will receive a graded exercise test, then followed a 9-weeks of exercise training. After 9-weeks of exercise training, the maximal oxygen consumption will be analyzed as a primary outcome of this study. Physiological parameters, hemodynamic outcome, respiratory function, and strength of lower limb muscle will be recorded. Effect： After 9 weeks' exercise training, VO2 will significantly improve in eccentric cycling exercise groups, furthermore, heart rate and perceived exertion will be lower in the eccentric cycling exercise combined with helmet ventilation. Key words： Pulmonary rehabilitation; eccentric cycling exercise; helmet ventilation; chronic respiratory disease

Official Title
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Comparison of Multiple Methods of Exercise Training for Accessing Maximal Oxygen Consumption, Skeletal Muscle Oxygen Saturation, and Cardiopulmonary Outcomes in Patients With Chronic Respiratory Disease

Conditions
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Chronic Pulmonary Disease

Intervention / Treatment
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* Device: Eccentric bike
* Device: Helmet ventilation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age between 20 and 80 years Diagnosed with chronic respiratory diseases Having undergone pulmonary rehabilitation for more than 3 months Exclusion Criteria: Existing of tracheostomy Those who use oxygen therapy or ventilator at home Severe left heart failure (NYHA III-IV) Neuromuscular disease Acute exacerbation within the past three months Those who are unable to cooperate with the cardiopulmonary exercise test

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control group<br>Self-paced exercise | |
| Experimental: Intervention Group: eccentric cycling exercise<br>Received eccentric cycling exercise | Device: Eccentric bike<br>* Received eccentric cycling exercise<br>|
| Experimental: Intervention Group: eccentric cycling exercise with helmet ventilation<br>Eccentric cycling exercise combined with helmet ventilation | Device: Eccentric bike<br>* Received eccentric cycling exercise<br>Device: Helmet ventilation<br>* Using helmet ventilation during eccentric cycling exercise<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peak % of oxygen consumption | To observe the maximum exercise performance | 9 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart rate, b/m | Cardiac hemodynamic parameter | 9 weeks | 
| Respiratory rate, b/m | Pulmonary parameter | 9 weeks | 
| Mean arterial blood pressure, mmHg | Cardiac hemodynamic parameter | 9 weeks | 
| FEV1/FVC, % | Pulmonary function | 9 weeks | 
| Saturation of Peripheral Oxygen(SpO2), % | Blood oxygenation | 9 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pulmonary rehabilitation, Eccentric cycling exercise, Helmet ventilation, Chronic respiratory disease