Comparisons of Two Airway Clearance Techniques

Study Overview
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Brief Summary
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The goal of this clinical trial is to compare the effectiveness of two airway clearance techniques for patients with ventilator associated pneumonia. The main questions it aim to answer are: effect of the therapies on volume changes outcome on sputum clearance Participants will receive airway clearance techniques of chest physiotherapy high frequency chest wall oscillation.

Detailed Description
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Sputum can be accumulated in the airways of intubated patients, resulting in recurrent pneumonia. The airway clearance therapy is often utilized with chest physiotherapy or high frequency chest wall oscillation which has become popular for its easy of use and less time consuming to the healthcare workers. The main questions it aim to answer are on effectiveness of the therapies on lung volume changes and sputum clearance by two airway clearance techniques. With the oscillation of entire chest wall, the investigators hypothesize that the high frequency chest wall oscillation is more effectively clear sputum in the distal airways.

Official Title
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Comparison of Two Airway Clearance Techniques by Electrical Impedance Tomography- a Parallel Study

Conditions
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Airway Clearance Impairment

Intervention / Treatment
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* Procedure: high frequency chest wall oscillation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed with chronic pulmonary disease Diagnosed with ventilator associated pneumonia Receive airway clearance therapy Exclusion Criteria: Head injury, spinal injury Instable hemodynamics Intercranial pressure > 20 cmH2O Active hemoptysis Empyema Eye surgery Abdominal distension Chest tube insertion Active tuberculosis

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Chest physiotherapy<br>Patients receive airway clearance by chest physiotherapy for 30 minutes twice a day. | Procedure: high frequency chest wall oscillation<br>* Patients receive airway clearance by high frequency chest wall oscillation for 30 minutes twice a day.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| end-expiratory lung impedance | Changes of global of impedance of lungs measure by the electrical impedance tomography | Measurement before intervention, 30 after, 1 hour and 2 hours after intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weight of secretions | Sputum amount is weighted. | Sputum is collected before intervention, 30 after, 1 hour and 2 hours after intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Airway clearance technique, Ventilator associated pneumonia, Electrical impedance tomography, High frequency chest wall oscillation, Chest physiotherapy