Analyses of Anemia in Very Low Birth Weight (VLBW) Infants.

Study Overview
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Brief Summary
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To study and analyze the association of the severity of anemia with neonatal morbidity and the risk factors of anemia in ealry life (less than 3 days of life) among the very low birth weight (VLBW) infants.

Detailed Description
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The rescue treatment of very low birth weight (VLBW) infants is the main task of our neonatal intensive care unit (NICU) is this era. Anemia of prematurity (AOP) is one of the most common complication of these infants, which can affect their growth, intelligence, behavior, immunity and hemodynamics, and even endanger their lives in severe situation. It is of great significance to investigate the association of the severity of anemia with neonatal morbidity and the risk factors of anemia in ealry life for improving the prognosis of these infants. Patient Registry procedures: First, the list of VLBW infants was obtained through medical record search, and sent to the principal investigator (PI) at each center when an infant was eligible for enrollment. Second, patients are included in this study according to the exclusion criteria by PI. Finally, the PI at each center will be responsible for the accuracy,completeness or representativeness of medical records, registry forms,data collection. Statistical analysis:The two groups were compared by a Χ2-test for categorical variables, Mann-Whitney U Test were used when reporting medians.A P value of <0.05 was considered statistically significant.

Official Title
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Analyses of Anemia Risk Factors and Prognosis in VLBW Infants.

Conditions
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Very Preterm Maturity of Infant, The Risk Factors for Improving the Prognosis of VLBW Infants

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Preterm infants less than 32 weeks of gestational age and birth weight below 1500 g and who survive to NICU are eligible for the trial. Anemia was defined as a central venous hemoglobin harvested in the first 3 days of life less than two standard deviations below the mean for postnatal age. Exclusion Criteria: Asphyxia (arterial pH <7.0, fifth minute Apgar score <3), Twin-to twin-transfusion syndrome, Discordant twins (difference in birth weight >20%), Major congenital anomalies or chromosomal anomalies, Disagree of parents.

Ages Eligible for Study
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Maximum Age: 4 Months

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Anemia group<br>The very low birth weight (VLBW) infants meet the diagnostic criteria of neonatal anemia during hospitalization between January 2020 and January 2023. | Other: No intervention<br>* Retrospect study, no direct intervention<br>|
| Control group<br>The very low birth weight (VLBW) infants are included without anemia during hospitalization between January 2020 and January 2023. | Other: No intervention<br>* Retrospect study, no direct intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anemia of prematurity (AOP) development in very low birth weight (VLBW) infants | The incidence of AOP in the first 72 hours of life in VLBW infants | Through study completion, an average of three months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risk factor of AOP among VLBW infants | The maternal hemoglobin (Hb) levels before birth among VLBW infants with AOP and without. | Through study completion, an average of three months | 
| Mortality or Bronchopulmonary Dysplasia (BPD) among VLBW infants with AOP | The incidence of death or BPD among VLBW infants with AOP and without. | Through study completion, an average of three months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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VLBW, anemia, risk factors, prognosis