Heart Failure Treatment Pattern Analysis of HF Patients in HF Centers and Non-HF Centers in China

Study Overview
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Brief Summary
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This is a retrospective, researcher-initiated, database-based study that will retrospectively observe the treatment and medication patterns of about 22,500 patients with heart failure from 25 heart failure centers and 25 non-heart failure centers in the database of heart failure center. The proportion of patients with heart failure treatment drugs reaching the target dose recommended in the guidelines and discontinuation rate will be observed at 1 month, 3 months and 12 months follow up time point. The purpose of this study is to illustrate the current HF treatment status in HF center hospitals and non-HF center hospitals, which may provide insights for improving the clinical practice of heart failure treatment in China, and promote the standardization of heart failure treatment in China.

Official Title
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Heart Failure Treatment Pattern Analysis of HF Patients in HF Centers and Non-HF Centers in China: a Retrospective Database-based Study

Conditions
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Heart Failure

Intervention / Treatment
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* Other: no intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: An index HF diagnosis date in the records Age ≥ 18 years old at initial diagnosis date HF patients baseline characteristic record Exclusion Criteria: eGFR<30 ml/min/1.73m²

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| HF center<br>heart failure patients enrolled from heart failure center hospitals | Other: no intervention<br>* no intervention<br>|
| non-HF center<br>heart failure patients enrolled from non-heart failure center hospitals | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of GDMT drugs (classified as RAASi (including ARNI), beta blockers, MRA and SGLT2i) | Numbers of GDMT drugs of HF patients stratified by HF ejection fraction and by HF Center and Non-HF Center | At baseline and at 1 month, 3 month, 12 month follow-up time point | 
| Use rates of GDMT drugs | The percentage of patients using each GDMT drug，stratified by HF ejection fraction and by HF Center and Non-HF Center | At baseline and at 1 month, 3 month, 12 month follow-up time point | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The proportion of patients using 2 types of GDMT drugs | The percentage of patients using 2 of any 4 GDMT drugs，stratified by HF ejection fraction and by HF Center and Non-HF Center | At baseline and at 1 month, 3 month, 12 month follow-up time point | 
| The proportion of patients using 3 types of GDMT drugs | The percentage of patients using 3 of any 4 GDMT drugs，stratified by HF ejection fraction and by HF Center and Non-HF Center | At baseline and at 1 month, 3 month, 12 month follow-up time point | 
| The proportion of patients using 4 types of GDMT drugs | The percentage of patients using all types of GDMT drugs，stratified by HF ejection fraction and by HF Center and Non-HF Center | At baseline and at 1 month, 3 month, 12 month follow-up time point | 
| The proportion of patients with each GDMT drug in the target dose | The percentage of patients who achieved the target dose of each GDMT drug, stratified by HF ejection fraction and by HF Center and Non-HF Center | at 1 month, 3 month, 12 month follow-up time point | 
| Discontinuation rate of each GDMT drug | The percentage of patients who discontinued GDMT drugs, stratified by HF ejection fraction and by HF Center and Non-HF Center | at 1 month, 3 month, 12 month follow-up time point |