An Imaging Study of Polyvascular Disease

Study Overview
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Brief Summary
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Establish a multimodality imaging database for PVD, improve the one-stop screening process for early PVD based on artificial intelligence, build a full-cycle control information platform, and promote the construction and standardization of a multidisciplinary co-morbidity and co-management diagnosis and treatment model. Based on non-invasive, zero-contrast ocular OCTA combined with one-stop CTA imaging of the heart and brain, construct an integrated eye-heart-brain early warning model for PVD, and explore a potential non-invasive and convenient early warning system for PVD. Based on the multi-omics, investigate EVs-mediated intercellular communication network, elucidate the roles and regulatory mechanisms of EVs in the development of PVD, search for potential targets for intervention, and construct an artificial intelligence-based pan-vascular score risk assessment system based on the combination of multi-modality imaging and multi-omics biomarkers.

Official Title
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Early Screen, Systematic Evaluation and Risk Warning of Polyvascular Disease Based on Multi-modality Imaging

Conditions
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Polyvascular Disease

Intervention / Treatment
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* Diagnostic Test: Magnetic Resonance Angiography, Ocular OCTA, CT Angiography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Task 1: Patients with coronary artery disease (≥50% stenosis in any coronary artery on coronary angiography) Age ≥18 years old Proposed OCT-IVUS integrated imaging system able to provide written informed consent prior to the start of any procedures related to the study. Task 2: patients with coronary artery disease (coronary angiography reveals ≥50% degree of stenosis in any coronary artery) and patients with stroke or TIA (confirmed by a neurologist) Age ≥ 18 years able to provide written informed consent prior to the start of any procedures related to the study. Exclusion Criteria: Task 1: severely tortuous/calcified coronary arteries with anticipated difficulty in completing the OCT-IVUS integrated imaging system uncontrolled congestive heart failure or acute left heart failure;plan claustrophobia; left main stem occlusion; proposed coronary artery bypass grafting (CABG); uncontrolled severe ventricular arrhythmia; active bleeding or severe bleeding tendency; acute stroke; patients with hemodynamic instability or unstable cardiac electrical activity (including shock) ; severe renal insufficiency and/or anuria, except in cases where dialysis treatment has been planned; contraindications to the application of contrast media; patients who are severely uncooperative due to psychiatric or serious systemic illness; Patients who, in the opinion of the investigator, are unsuitable for participation in the study. Task 2: patients who are unable to comply with the follow-up schedule; uncontrolled congestive heart failure or acute left heart failure; patients with a life expectancy of less than 6 months; left main stem occlusion; proposed coronary artery bypass grafting (CABG); uncontrolled severe ventricular arrhythmia; active bleeding or severe bleeding tendency; patients with hemodynamic instability or unstable cardiac electrical activity (including shock) ; severe renal insufficiency and/or anuria, except in cases where dialysis treatment has been planned; contraindications to the application of contrast media; patients who are severely uncooperative due to psychiatric or serious systemic illness; patients who, in the opinion of the investigator, are not suitable for participation in the study.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Polyvascular disease<br> | Diagnostic Test: Magnetic Resonance Angiography, Ocular OCTA, CT Angiography<br>* Magnetic Resonance Angiography of intracranial artery, carotid artery, renal artery and lower extremity artery, CT angiography of coronary artery or intracranial artery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Task1: MACE | All cause death, stroke, myocardial reinfarction, unplanned revascularization, lower extremity artery disease | 1 year | 
| Task2: Plaque characteristics | Plaque morphology on OCT | 1 year |