linjc16/ctgov huggingface dataset:
Diagnostic Efficacy of Metagenomic Next-generation Sequencing in Patients With Spinal Infections: A Retrospective Study

Study Overview
=================
Brief Summary
-----------------
Comparing the diagnostic efficacy between traditional laboratory methods and second-generation high-throughput sequencing in patients suspected of spinal infections.

Official Title
-----------------
Diagnostic Efficacy of Metagenomic Next-generation Sequencing in Patients With Spinal Infections: A Retrospective Study

Conditions
-----------------
Spinal Infection, Diagnositic Efficacy

Intervention / Treatment
-----------------
* Other: No interventions


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients suspected of spinal infections, as per the American Infectious Diseases Society's 2015 criteria for primary vertebral osteomyelitis, were identified based on their clinical symptoms, laboratory tests, and imaging examinations. All cases included in the study underwent laboratory examinations, histopathological examinations, and second-generation high-throughput sequencing (metagenomic sequencing). Exclusion Criteria: The absence of laboratory examinations, histopathological examinations, and results from second-generation high-throughput sequencing (metagenomic sequencing).

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sun Yat-sen memorial hospital<br>Patients who were suspected of Spinal infection. | Other: No interventions<br>* No intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The diagnositic efficacy | Sensitivity, Specificity | 1 year | 
| The diagnositic efficacy | Positive Predictive Value, Negative Predictive Value | 1 year |
A Companion Diagnostic Study to Develop Circulating Exosomes as Predictive Biomarkers for the Response to Immunotherapy in Renal Cell Carcinoma

Study Overview
=================
Brief Summary
-----------------
Immune checkpoint inhibitors targeting PD-1 or PD-L1 have been developed and clinical trials showning better response in unselected patients with metastatic renal cell carcinoma (RCC). At the moment, no clear biomarker exists to accurately predict anti-PD1/PDL1 RCC responsiveness. The objective of this study is to develop and evaluate the utility of circulating exosomes as companion diagnostic biomarker for predicting response to immunotherapy in patients with RCC.

Official Title
-----------------
A Companion Diagnostic Study to Develop Circulating Exosomes as Predictive Biomarkers for the Response to Immunotherapy in Renal Cell Carcinoma

Conditions
-----------------
Renal Cell Carcinoma

Intervention / Treatment
-----------------
* Other: Other: Blood and Urine Collection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Advanced Metastatic RCC Scheduled to initiate an immunocheckpoint inhibitors or in combination with them Age >= 18 years Able to provide informed consent Exclusion Criteria: Other, unrelated, concomitant active, invasive malignancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Other: Blood and Urine Collection|Blood and Urine Collection|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The correlation between the circulating exosomes levels and the tumor responsiveness | The Measurement： The concentration of ciruculating exosomes and the expression level of exosomal RNA. The Measurement Tool: RT-PCR，WB and Elisa | 3 years |
Comparison of Turkish Children's Actual Weights With Which Predicted Weights by Estimation Methods

Study Overview
=================
Brief Summary
-----------------
The goal of this observational study is to compare body weigth with the prediceted weigth values abtracted by weigth estimation methods in Turkish Children. The main question it aims to answer is: to evaluate the suitability of APLS, Luscombe & Owens, Best Guess, Nelson Formula and Broselow Band methods in estimating actual measurements in patients coming to the surgery outpatient clinic of our hospital

Official Title
-----------------
Comparison of Turkish Children's Actual Weights With Predicted Weights Values by APLS, Luscombe and Owens, Best Guess, Nelson Formulas and Broselow Band Methods

Conditions
-----------------
Pediatric Hernia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria:admitted to the pediatric surgery clinic 0-18 years old patients will be included Exclusion Criteria:Those who have a disease that will cause severe developmental growth retardation will be excluded

Ages Eligible for Study
-----------------
Minimum Age: 0 Days
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of actual weigth with predicted weigth |  | one year |
Investigation of a 3 oz Water Protocol on Patients With Tracheostomies

Study Overview
=================
Brief Summary
-----------------
Examining the validity of a novel 3 oz protocol in patients with tracheostomies as compared to the gold standard of instrumental swallow assessments (Flexible Endoscopic Evaluation of the Swallow or Modified Barium Swallow Study).

Detailed Description
-----------------
The purpose of this research study is to determine if a 3 oz water screening protocol is an effective screen for patients with openings in their airways (i.e. tracheostomies). This procedure is already in use for many different populations and is particularly useful for clinicians who want to understand who is at risk for having food or liquid enter the lungs while eating or drinking (i.e. aspiration).

Official Title
-----------------
Investigation of a 3 oz Water Protocol on Patients With Tracheostomies

Conditions
-----------------
Tracheostomy

Intervention / Treatment
-----------------
* Other: 3 Oz water screen


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Has a tracheostomy Able to remain alert for testing Not on a modified diet for pre-existing dysphagia No head of bed restrictions Not NPO by physician for any reason other than possible dysphagia At least 18 years old Exclusion Criteria: Does not have a tracheostomy Unable to remain alert for testing On a modified diet due to pre-existing dysphagia Head of bed restrictions for greater than or equal to 30 degrees NPO by physician for reasons other than possible dysphagia Less than 18 years old

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with Tracheostomies<br>Patients with openings in their airways (i.e. tracheostomies) | Other: 3 Oz water screen<br>* Patient will consume 3 oz of water continuously without stopping and then will be monitored for one minute post completion. Patient will complete this twice in the same session.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Swallow screen | Swallow screen measured as pass/fail for presence or absence of aspiration | End of participation study within 7 days of enrollment | 
| Penetration Aspiration Scale Score | The penetration aspiration scale (PAS) is a validated measure used by trained blinded clinicians to assign ratings of safety to swallowing bolus trials. The PAS is an 8-point, equal-appearing interval scale (8 being best; 1 being worst) to describe penetration and aspiration events. Scores are determined primarily by the depth to which material passes in the airway and by whether or not material entering the airway is expelled. Higher scores indicate better health outcomes. | End of participation study within 7 days of enrollment |
Knee Osteoarthritis, Aging and Metabolic Syndrome

Study Overview
=================
Brief Summary
-----------------
Osteoarthritis (OA) is the most prevalent form of arthritis. Its pathogenesis remains poorly understood. Though historically regarded as a disease of mechanical degeneration, it is now appreciated that inflammation plays an important role in OA pathogenesis

Detailed Description
-----------------
Place of the study: Sohag university hospital. Type of study: Cross-Sectional Observational study Study period: Six months to one year The study will include Patients who met the American College of Rheumatology (ACR) clinical criteria for knee OA . The following details will be obtained: Demographic data : Age ,Sex ,Marital status ,Occupation ,Residence ,Education level ,Anthropometrical measures which included waist circumference (WC) and blood pressure (BP) will be obtained,History of chronic diseases (eg; Diabetes mellites, Hypertension) Clinical information: Symptom and its Duration. Plain radiographs of at least one knee [anteroposterior (A/P), lateral} will be taken. Laboratory findings included fasting blood sugar, serum levels of triglycerides, High-density lipoprotein cholesterol and total cholesterol.

Official Title
-----------------
What Affects the Severity of Knee Osteoarthritis? Aging or Associated Metabolic Syndrome

Conditions
-----------------
Knee Osteoarthritis

Intervention / Treatment
-----------------
* Diagnostic Test: xray


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who met the American College of Rheumatology (ACR) clinical criteria for knee OA and had symptomatic OA of at least 1 knee (index knee), with a Kellgren / Lawrence (K/L) score ≥ 1 in that knee Exclusion Criteria: Any patient with a history of trauma to the knee Any other form of arthritis (e.g., rheumatoid arthritis, seronegative spondyloarthropathies, gout, pyrophosphate disease, or other crystal arthropathy)

Ages Eligible for Study
-----------------
Minimum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| knee osteoarthritis<br>Knee osteoarthritis | Diagnostic Test: xray<br>* radiological description<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| severity of knee osteoarthritis | Kellgren and Lawrence (K/L) grading system of Knee osteoarthritis. It assigned a grade from 0 to 4, which they correlated to increasing severity of OA, with Grade 0 signifying no presence of OA and Grade 4 signifying severe OA . | 8/2023-8/2024 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
knee osteoarthritis, Aging, Metabolic Syndrome
Long-term Outcomes After Epigastric Hernia Repair in Women - a Nationwide Database Study

Study Overview
=================
Brief Summary
-----------------
The aim was to evaluate outcomes after epigastric hernia repair in women on a nationwide basis. The primary outcome iss recurrence - secondary outcomes are readmission, operation for complication, risk factors for recurrence, and readmittance.

Detailed Description
-----------------
Aim Outcomes after epigastric hernia repair are rarely reported independently. Furthermore, women have the highest prevalence of epigastric hernia repair in the age of 41-50 years. The aim of this study was to evaluate long-term outcomes after epigastric hernia repairs in women on a nationwide basis. Methods Nationwide database cohort study using prospectively recorded data from the Danish Hernia Database from women undergoing elective repair for epigastric hernias, during a 4-year period (2018-2021). A 100% follow-up was obtained by combining intra-operative data with data from the National Civil Register (NRC). The primary outcome was operation for recurrence, secondary outcomes were readmission and operation for complications. We compared open vs. laparoscopic repairs, and subgroup analysis were made for open repairs (sutured vs. mesh).

Official Title
-----------------
Long-term Outcomes After Epigastric Hernia Repair in Women - a Nationwide Database Study

Conditions
-----------------
Epigastric Hernia, Women With Epigastric Hernias

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All female patients undergoing elective repair with a laparoscopic or open technique for an epigastric hernia were included. Exclusion Criteria: umbilical or incisional hernias, male patients, recurrent hernia repairs, and hernia repairs performed in relation to other surgical procedures.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 120 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| women undergoing epigastric hernia repair<br>all women who have undergone epigastric hernia repair open or laparoscopic in Denmark during af 4-year period from January 1st, 2018, to Dec 31st, 2021. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| operation for recurrence | operation for recurrence during the observation period | 4 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Readmittance | readmittance within 90 days after repair | 90 days | 
| operation for complications | 90 days operation for complications | 90 days |
Subthreshold Stimulation on Chronic Low Neck Pain Myofascial Trigger Points

Study Overview
=================
Brief Summary
-----------------
This study will investigate the effect of subthreshold stimulation on pain and muscle activity in patients with chronic low neck pain and myofascial trigger points.

Detailed Description
-----------------
The study will include 2 groups. One group will receive subthreshold stimulation and other will not receive any treatment. The measurements will include pain and myscle activity.

Official Title
-----------------
Effect of Subthreshold Stimulation on Pain and Muscle Activity in Patients With Chronic Low Neck Pain and Myofascial Trigger Points

Conditions
-----------------
Chronic Neck Pain

Intervention / Treatment
-----------------
* Device: Subthreshold Electrical stimulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: chronic neck pain One or more trigger point Exclusion Criteria: any musculoskeletal or neuromuscular diseases

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group 1<br>This group will receive subthreshold stimulation | Device: Subthreshold Electrical stimulation<br>* We will use a electrotherapy device to deliver subthreshold Electrical stimulation<br>|
| No Intervention: Group II<br>This group will receive no stimulation | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Electromyographical signals | We will record the the Trapezius muscle activity of both sides. | 2 months | 
| Pressure sensitivity using pressure ergometer | We will measure pain threshold produced from Trapezius muscle | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neck pain and disability | We will record the level of pain and disability in neck using neck pain and disability index. standard instrument for measuring self-rated disability due to neck pain and is used by both clinicians and researchers. Each of the 10 items scores from 0 to 5. The maximum score is 50. The obtained score can be multiplied by two to produce a percentage score | 2 months | 
| Functional ability | We will measure the functional ability. The Copenhagen Neck Functional Disability Scale has been developed for those who have neck pain and disabilities due to the pain. The scale includes questions relating to headache, ability to sleep and to concentrate and activities of daily living. | 2 months |
Stone Disease of the Urinary Tract in Children

Study Overview
=================
Brief Summary
-----------------
The incidence of stone disease of the urinary tract in children is increasingly increasing with a remarkable economic impact for its management. This incidence is variable according to race, geographic region, socio-economic status and dietary habits. Oxalo-calcium stones are the most common but the biochemical nature of urinary stones varies depending on the region where those of a phosphatic nature are characterized by a higher incidence in Europe. The diagnosis is confirmed by imaging. The unprepared abdomen (ASP) has low diagnostic accuracy. The scanner is the reference tool but remains an irradiating examination. Risk factors for disease recurrence include primarily the presence of an underlying urinary metabolic abnormality and young age. Urinary metabolic abnormalities vary from one study to another. The understanding of lithogenesis, its evaluation as well as the therapeutic options is essential for adequate and adapted management in the pediatric population.

Official Title
-----------------
Stone Disease of the Urinary Tract in Children: Clinical Presentation, Diagnostic Methods, Therapeutic Management, Evolution and Prognosis

Conditions
-----------------
Urinary Lithiasis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Patients aged less than 18 years. Both sexes. Subjects presenting with lithiasis of the urinary tree in one of the two departments concerned between 01/01/2010 and 12/31/2022 Subject not opposing, after information, the reuse of their data for the purposes of this research. Holders of parental authority who do not object, after being informed, to the reuse of their child's data for the purposes of this research. Exclusion criteria: Subject or holder of parental authority having expressed opposition to participating in the study. Non-usable patient files: insufficient data.

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Study of the modalities of the therapeutic management of children with urinary stones, retrospective description of the evolutionary aspects and the risk factors associated with recurrence. | This study is retrospective on already existing data | Files analysed retrospectively from January 01, 2010 to December 31, 2022 will be examined | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Urinary Lithiasis, Stone disease, Urolithiasis, Urinary Calculi
Vowel Segmentation for Classification of Chronic Obstructive Pulmonary Disease Using Machine Learning

Study Overview
=================
Brief Summary
-----------------
This work aims to evaluate whether the segmentation of vowel recordings collected from patients diagnosed with COPD and healthy control groups can increase the classification precision of machine learning techniques.

Detailed Description
-----------------
Voice data and sociodemographic data on gender and age will be collected through the VoiceDiganostic application from the company Voice Diagnostic. Collected vowel recordings will be segmented and tested to determine whether some segments contain more information for the discrimination of COPD from healthy control groups. Each segment will be transformed into mathematical vocal measures called voice features. A dataset consisting of voice features in conjunction with demographics and health data will be constructed for each segment which in turn will be evaluated for classification performance using several machine learning algorithms. Descriptive statistical analysis will be held on attributes containing information on input data and gained outcomes from ML algorithms. The achieved results will be presented in the form of summary tables and graphs.

Official Title
-----------------
Vowel Segmentation for Classification of Chronic Obstructive Pulmonary Disease Using Machine Learning

Conditions
-----------------
Chronic Obstructive Pulmonary Disease

Intervention / Treatment
-----------------
* Other: COPD


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: being 18 years old and older. Exclusion Criteria: being under 18 years old and older.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COPD<br>30 COPD participants, 16 Female and 14 Male. | Other: COPD<br>* A vowel segmentation data set consisting of information from COPD and HC groups will be used to experiment with the classification performance of several Machine Learning techniques on different segments of a vowel recording.<br>* Other names: HC;|
| HC<br>38 HC participants, 20 Female and 18 Male. | Other: COPD<br>* A vowel segmentation data set consisting of information from COPD and HC groups will be used to experiment with the classification performance of several Machine Learning techniques on different segments of a vowel recording.<br>* Other names: HC;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Classification performance | Binary classification performance of the ML algorithm on each segment. | 30 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Segmentation, Classification, COPD, Machine Learning