Bio-electrical Impedance Analysis Derived Parameters for Evaluating Fluid Accumulation

Study Overview
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Brief Summary
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The purpose of this study is to assess fluid accumulation (FA) in the body using BIA (Bioelectrical Impedance Analysis) in critically ill patients treated in the ICU. This study is an observational cohort with an initial phase that analyzes prospective individual patient data

Detailed Description
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This research will begin by identifying subjects through the collection of initial data. The identification of subjects will involve using BIA (Bioelectrical Impedance Analysis) equipment. Subsequently, the subjects will be divided into two groups based on the initial BIA test results of body fluid balance. The first group will comprise patients with a body fluid balance exceeding 500cc, while the second group will consist of patients with a body fluid balance of 500cc or less. Throughout the study, various BIA-derived parameters will be closely monitored for both groups, starting from the initial BIA test until the patients are discharged from the ICU or for a maximum of 7 days of ICU care from the time of the first test.

Official Title
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The Use of Bio-Electrical Impedance Analysis Derived Parameters for Evaluating Fluid Accumulation in Critically Ill Patients Admitted to ICU: a Cohort Study

Conditions
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Critically Ill

Intervention / Treatment
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* Other: Bio-electrical Impedance Analysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: New patients admitted to Intensive Care Unit Cipto Mangunkusumo Hospital and Indonesia University University Willing to be included in this research and signed the consent form Exclusion Criteria: Obesity(BMI>35kg/m²) OR underweight (BMI < 18,5 kg/m²) Pregnant or Breastfeeding

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Positive Fluid Balance 500ml or more<br>Fluid Balance measured using Bio-electrical Impedance Analysis | Other: Bio-electrical Impedance Analysis<br>* Variable measured: Fluid accumulation (FA), volume excess (VE), total body weight (TBW), extracellular water (ECW), intracellular water (ICW)<br>|
| Fluid Balance 500ml or less<br>Fluid Balance measured using Bio-electrical Impedance Analysis | Other: Bio-electrical Impedance Analysis<br>* Variable measured: Fluid accumulation (FA), volume excess (VE), total body weight (TBW), extracellular water (ECW), intracellular water (ICW)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fluid accumulation (FA) | Each increase in volume excess is divided by the patient's initial body weight and expressed as a percentage. FA (fluid accumulation) is considered positive if the percentage value is greater than 5%. Conversely, FA is considered negative if the percentage value is less than 5%. | 1 week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| volume excess (VE) | Fluid volume expansion outside the cells, based on the assessment by BIA (Bioelectrical Impedance Analysis), refers to the increase in fluid volume that occurs outside the cells of the body. | 1 week | 
| total body weight (TBW) | The total mass or weight quantity of a person is obtained from BIA (Bioelectrical Impedance Analysis) measurements. | 1 week | 
| extracellular water (ECW) | The amount of ECW (liters) | 1 week | 
| intracellular water (ICW) | The amount of ICW (liters) | 1 week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Bio-electrical Impedance Analysis, Fluid Accumulation