ChAracterization of Normal and Pathological moRphological Variations of the TEMporomandibular Joint by Real-time magnetIc reSonance Imaging

Study Overview
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Brief Summary
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The Real Time MRI Rapid Flash sequence is particularly interesting for the study of moving organs and joints. This sequence will make it possible to characterize normal and pathological temporomandibular joint movements by MRI.

Official Title
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ChAracterization of Normal and Pathological moRphological Variations of the TEMporomandibular Joint by Real-time magnetIc reSonance Imaging

Conditions
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Healthy, Temporomandibular Joint Disorders

Intervention / Treatment
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* Device: MRI with Real Time MRI Rapid Flash sequence


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult: age ≥ 18 years old; Person with the capacity to understand the instructions given; Person affiliated to a social security scheme or beneficiary of such a scheme; Person having received complete information on the organization of the Clinical Investigation and having signed informed consent. Exclusion Criteria: Person with large-scale metallic dental reconstructions; Edentulism more than 5 teeth; Claustrophobia; Contraindication to performing an MRI examination Persons referred to in Articles 64, 65 and 66 of European Regulation 2017/745 on Medical Devices (RDM) and in L. 1121-5 to L1121-8 of the French Public Health Code

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Healthy<br>Healthy volunteers | Device: MRI with Real Time MRI Rapid Flash sequence<br>* MRI examination of temporomandibular joint with Real Time MRI Rapid Flash sequence<br>|
| Other: Temporomandibular Joint Disorders<br>Patients with Temporomandibular Joint Disorders | Device: MRI with Real Time MRI Rapid Flash sequence<br>* MRI examination of temporomandibular joint with Real Time MRI Rapid Flash sequence<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Curve representing the difference between displacement of condyles during Temporo Mandibular Joint (TMJ) movements in healthy subjects and in subjects with known Temporo Mandibular Disorder (TMD). |  | Baseline (day 0) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Curve representing the displacement of the articular discs during TMJ movements |  | Baseline (day 0) | 
| Curve representing the difference between displacement of joint discs during TMJ movements in healthy subjects and in subjects with known TMD |  | Baseline (day 0) | 
| Characterization of the volume in mm3 of the main masticatory muscles during movement by MRI in healthy and pathological subjects. |  | Baseline (day 0) |