Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 2

Study Overview
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Brief Summary
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This study assess the ways in which e-cigarette product characteristics, such as flavors and nicotine salts, impact user experience to inform potential regulations.

Detailed Description
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There are three primary objectives to the study: (1) Determine which dimensions of e-cigarette product diversity differentially affect product appeal in the overall population of tobacco product users as well as affect product appeal across young adult e-cigarette users and middle-age/older adult smokers; (2) Determine which dimensions of e-cigarette product diversity differentially affect product appeal in the overall population of tobacco product users as well as affect abuse liability in young adult e-cigarette users and the ability to resist smoking in adult smokers; (3) Determine the affect of product characteristics on e-cigarette nicotine delivery profile.

Official Title
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Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 2

Conditions
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Electronic Cigarette Use, Cigarette Smoking, Cigarette Use, Electronic, Vaping

Intervention / Treatment
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* Other: E-cigarette


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Vapers/E-cigarette Users - Regular use of e-cigarettes/vaping devices containing nicotine Cigarette Smokers - Regular use of cigarettes containing nicotine Exclusion Criteria: Pregnant or planning to become pregnant

Ages Eligible for Study
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Minimum Age: 21 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Participants will be randomly assigned to use an e-liquid
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: E-Liquid 1<br>Participants will self-administer an assigned e-liquid. | Other: E-cigarette<br>* Participants will self-administer experimenter-provided e-cigarettes<br>|
| Experimental: E-Liquid 2<br>Participants will self-administer an assigned e-liquid. | Other: E-cigarette<br>* Participants will self-administer experimenter-provided e-cigarettes<br>|
| Experimental: E-liquid 3<br>Participants will self-administer an assigned e-liquid. | Other: E-cigarette<br>* Participants will self-administer experimenter-provided e-cigarettes<br>|
| Experimental: E-liquid 4<br>Participants will self-administer an assigned e-liquid. | Other: E-cigarette<br>* Participants will self-administer experimenter-provided e-cigarettes<br>|
| No Intervention: No e-liquid<br>Participants will not receive an e-liquid to self-administer. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subjective Appeal | This self-report measures of subjective product appeal will be completed following e-cigarette self-administration. Scores can range from 0 to 100 for the appeal rating, with lower scores representing lower levels of appeal and higher scores representing higher levels of appeal. | 1 hour | 
| Sensory Attributes | This self-report measures of product sensory attributes will be completed following e-cigarette self-administration. Scores can range from 0 to 100 for the sensory attribute rating, with lower scores representing lower levels of liking the sensory attribute and higher scores representing greater liking of the sensory attribute. | 1 hour | 
| Vaping Delay | Minutes delayed before purchasing time to vape an e-liquid. | 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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vaping, e-cigarette, vape, nicotine, tobacco