Neutrophil-lymphocyte and Platelet-lymphocyte Ratios and Their Relations to Vascular Comlications and Glycemic Control in Patients With Type 2 Diabetes Attending The Diabetes Center of Assiut University Hospitals

Study Overview
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Brief Summary
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Evaluate PLR and NLR and their assiotation to vascular complications and glycemic control in type 2 DM

Detailed Description
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Vascular complications of DM result from various disorders including metabolic, cellular, and blood disturbances. Excessive production of pro-inflammatory adipokines from adipose tissue, resulting in low-grade chronic inflammation, causing insulin resistance (IR) and type 2 DM [3]. Hematological changes affecting the red blood cells (RBCs), white blood cells (WBCs), platelet function, and the coagulation factors are detected to be associated with DM . It is important to add that, high WBC count, one of the chief components of inflammatory process, sharing to atheroscle-rosis development and cardiovascular diseases (CVD) . Lately, the neutrophil-to-lymphocyte (N/L) and the platelet-to-lymphocyte (P/L) ratios, were offered as markers of inflammation in cardiac diseases, neoplasms and diabetes-related complications . Moreover, high leucocyte counts have been used as diagnostic and prognostic markers in vascular complication of diabetes

Official Title
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Neutrophil-lymphocyte and Platelet-lymphocyte Ratios and Their Relations to Vascular Comlications and Glycemic Control in Patients With Type 2 Diabetes Attending The Diabetes Center of Assiut University Hospitals

Conditions
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Vascular Complication, Diabetic

Intervention / Treatment
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* Radiation: Echocardiogram


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Type 2 diabetes mellitus (T2DM) patients with good glycemic control and have HBA1C <7and ages ranging from ≥18 old. And poor glycemic control and have HBA1C ≥7 and ages rang from ≥ 18 years old Exclusion Criteria: Patients with, type 1 diabetes mellitus Idiopathic thrombocytopenic purpura, liver cell failure Myeloproliferative neoplasm patients on anticoagulant drugs , anti platelet drugs or on steroids were excluded from the study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Type 2 diabetes mellitus (T2DM) patients with good glycemic control and have HBA1C <7and ages ranging from ≥18 old. | Radiation: Echocardiogram<br>* Evaluate PLR and NLR and their assiotation to vascular complications and glycemic control in type 2 DM<br>* Other names: Echo;|
| 2<br>Type 2 diabetes mellitus (T2DM) patients with poor glycemic control and have HBA1C ≥7 and ages rang from ≥ 18 years old | Radiation: Echocardiogram<br>* Evaluate PLR and NLR and their assiotation to vascular complications and glycemic control in type 2 DM<br>* Other names: Echo;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neutrophil-to-lymphocyte ratio and platelets to lymphocytes ratio | Measurement of Neutrophils to lymhocyte ratio and platelets to lymhocyte ratio in patients with type 2 DM | Basline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HbA1c with good glycemic control and have HBA1C lower than 7and poor glycemic control and have HBA1C higher than 7with prescence or abscence of vascular complications | Evaluate PLR and NLR and their assiotation to vascular complications and glycemic control in type 2 DM | Basline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Neutrophils to lymhocyte ratio and platelets to lymhocyte ratio