Validation of a Screening Scale for Misuse of Opioid Analgesics

Study Overview
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Brief Summary
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In oncology, pain is one of the main symptoms of discomfort. It has a significant impact on the quality of life.The use of opioid analgesics is recommended for the treatment of moderate to severe cancer pain.The misuse of opioid analgesics is an international public health problem.Different scales have been developed to help the prescriber screen for the risk of misuse in the general population. Patients with cancer-related pain are also at risk for aberrant opioid-related behaviors, misuse or addiction. The main objectif of this study is to validate of the screening scale for the misuse of opioid analgesics in patients with chronic pain related to cancer. (Prescription Opioid Misuse Index - POMI).

Detailed Description
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The study takes place in 2 phases. Test phase : Questionnaire no. 1 constitutes the data for the TEST phase: it includes socio-demographic data, medical and family history, lifestyle, treatments, 5 questions from the Concise Pain Questionnaire (QCD), the French version of the POMI scale, the diagnostic criteria of the DSM-V and two questions concerning anxiety associated with pain and therapeutic education. Retest phase : questionnaire no. 2 10 to 15 days later.

Official Title
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Validation of a Screening Scale for the Misuse of Opioid Analgesics in Patients With Chronic Pain Related to Cancer.

Conditions
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Cancer, Pain, Opioid Analgesic Adverse Reaction

Intervention / Treatment
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* Other: Questionnaires


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged 18 and over, Patients with chronic cancer-related pain that has been evolving for at least 3 months, Patients with a regular prescription of at least one opioid analgesic medicine taken daily for at least 1 month, Patients followed in oncology for an active cancerous pathology. Exclusion Criteria: Stopping opioid prescriptions on the day of the test phase (no Retest possible), Patients in the process of weaning (risk of being weaned during the Retest phase), Patients unable to complete the questionnaire on their own, Patients followed in a pain or addiction centre, Patients in terminal palliative situations of their cancer, Patients with chronic pain that is more disabling than cancer-related pain, Patients refusing to participate, Patients under guardianship or curatorship, Pregnant or breastfeeding patients, Patient with a language barrier limiting understanding of the questionnaire in French.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cancer patients<br>Questionnaires | Other: Questionnaires<br>* questionnaire including socio-demographic data, medical and family history, lifestyle, treatments, 5 questions from the Questionnaire Concis sur les Douleurs (QCD), the French version of the POMI scale, the diagnostic criteria of the DSM-V and two questions concerning anxiety associated with pain and therapeutic education.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| POMI scale score - Prescription Opioid Misuse Index | 8-item self-assessment scale | day 1 | 
| POMI scale score - Prescription Opioid Misuse Index | 8-item self-assessment scale | day 15 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| QCD | Visual Analogue Scales (VAS) for assessing the intensity and daily impact of pain (0-10) | day 1 | 
| QCD | Visual Analogue Scales (VAS) for assessing the intensity and daily impact of pain (0-10) | day 15 | 
| Sociodemographic characteristics | Questionnaire about Sociodemographic characteristics of patients | day 1 | 
| Lifestyle habits, other consumption | Questionnaire about Lifestyle habits, other consumption | day 1 | 
| Analgesic treatments | Questionnaire about Ongoing analgesic treatments | day 1 | 
| Use of analgesics | Question evaluating the use of analgesics in the context of anticipating pain | day 1 | 
| Use of analgesics | Question evaluating the use of analgesics in the context of anticipating pain | day 15 |