Resistance Exercise Training in Children.

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is examine the effects of 8 weeks (3 days/week) of resistance exercise training in children 8 to 10 years of age on muscle strength, activation, and lipids of the vastus lateralis.

Official Title
-----------------
The Effects of Resistance Exercise on Muscle Activation and Lipids in Children

Conditions
-----------------
Resistance Training

Intervention / Treatment
-----------------
* Other: Resistance exercise training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy volunteer males and females ages 8 - 10 years. Exclusion Criteria: No history or ongoing neuromuscular diseases, musculoskeletal injuries, or a disease that effects metabolism.

Ages Eligible for Study
-----------------
Minimum Age: 8 Years
Maximum Age: 10 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Resistance exercise training<br>Participants undergo 8 weeks (3 days/week) of resistance exercise training. | Other: Resistance exercise training<br>* Traditional linear periodization resistance training.<br>|
| No Intervention: Control<br>Participants do not perform 8 weeks of resistance exercise training. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in the muscular strength of leg extensors, as measured with isometric strength. | The score will reflect the strength of the leg extensors. The higher score, reflects greater muscular strength. | baseline, following the intervention (9 weeks) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline in motor unit firing rates during a 60% of maximal voluntary contraction (MVC). | Scores are measured with the y-intercept from the firing rates versus recruitment threshold relationships from the 60%. The higher y-intercept score reflects greater muscle activation. | baseline, following the intervention (9 weeks) | 
| Change from baseline in motor unit firing rates during a 60% of maximal voluntary contraction (MVC). | Scores are measured with the slope from the firing rates versus recruitment threshold relationships from the 60%. The higher slope score reflects greater muscle activation. | baseline, following the intervention (9 weeks) | 
| Change from baseline in thigh muscle cross-sectional area. | Scores are measured cross-sectional area from ultrasound images. | baseline, following the intervention (9 weeks) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
exercise, muscle cross-sectional area, intramyocellular lipids, extramyocellular lipids, strength