Maxillary Canine Retraction Assisted With Micro-osteoperforations Versus Injectable Platelet Rich Fibrin

Study Overview
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Brief Summary
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The present clinical comparative study will be undertaken for assessment of two different modalities of maxillary canine retraction assisted with microosteoperforations versus injectable platelet rich fibrin.

Detailed Description
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Group I: will include 9 patients who willreceive MOPs with maxillary canine retraction that will be performed on intervention sides according to a standardized protocol. ▪ Group II: will include 9 patients receive i-PRF that will be performed on intervention sides according to a standardized protocol.

Official Title
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Assessment of Two Different Modalities of Maxillary Canine Retraction Assisted With Micro-osteoperforations Versus Injectable Platelet Rich Fibrin: A Comparative Clinical Study

Conditions
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Effects of; Movement of Teeth Assiste Wit MOPS and I-prf

Intervention / Treatment
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* Combination Product: injectable platelet rich fibrin versus microosteoperforation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: An age ranges from 15-22 years. Severe crowding or protrusion requiring 1st premolars extractions followed by symmetrical canine retraction. All permanent teeth present, 3rd molars are excluded. Good oral and general health. No systemic disease/medication that could interfere with OTM. No previous orthodontic treatment. Exclusion Criteria: Patient diagnosed to have an indication for non-extraction approach. Poor oral hygiene or periodontally compromised patient. Patient with craniofacial anomalies or previous history of trauma, bruxism or parafunctions. Previous orthodontic treatment.

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 22 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group MOPs<br>Group MOPs : will include 9 patients who willreceive MOPs with maxillary canine retraction that will be performed on intervention sides according to a standardized protocol. | Combination Product: injectable platelet rich fibrin versus microosteoperforation<br>* injectable platelet rich fibrin which is second product of blood versus microosteoperforation which is surgical procedure<br>|
| No Intervention: Group IMOPS<br>other side in group which is control group | |
| Experimental: Group i-PRF<br>group i-PRF: will include 9 patients receive i-PRF that will be performed on intervention sides according to a standardized protocol | Combination Product: injectable platelet rich fibrin versus microosteoperforation<br>* injectable platelet rich fibrin which is second product of blood versus microosteoperforation which is surgical procedure<br>|
| No Intervention: group i-PRF2<br>other side in group which is control group | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Direct clinical assessment of the amount of maxillary canine retraction i.e. amount of extraction space closure before and after four months observation period and on every 28 days observation period according to standardized method | Direct clinical assessment of the amount of maxillary canine retraction i.e. amount of extraction space closure before and after four months observation and every 28 days period and on every 28 days observation period according to standardized method. 2. Study cast assessment: • The amount of maxillary canine retraction on both sides will be measured immediately before starting canine retraction and at each observation interval by using a software for the scanned models according to standardized method | 4months |