Dehydration Cognition

Study Overview
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Brief Summary
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The investigators want to understand the impact of the body losing and gaining water on brain function. Participants will restrict fluids consumed and exercise to lose 5% of body mass. Participants will then be provided fluid equal to the volume lost to consume over 2 hours (recovery). A series of brain function tests will be performed at baseline, following weight loss, and following recovery.

Detailed Description
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A baseline series of brain function tests will be performed. Following this, participants will complete a 24 hour fluid and water rich food restriction on the day proceeding testing. Participants will then complete moderate to high intensity exercise in a hot/humid room to achieve 5% body mass loss. Once baseline core body temperature returns to baseline levels, the series of brain function tests will be performed. Participants will then consume a sports drink equal to the volume of sweat lost over the course of a 2 hour recover period. Following this, he series of brain function tests will be performed.

Official Title
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Impact of Dehydration and Rapid Rehydration on Cognitive Function

Conditions
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Dehydration

Intervention / Treatment
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* Behavioral: Fluid loss and consumption


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy Recreationally active 18-26 years old Exclusion Criteria: History of cardiovascular, metabolic, respiratory, neural, or renal disease Hypertensive (systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg) or tachycardic (resting heart rate ≥ 100 bpm) during the screening visit Taking medication or supplements with a known side effect of affecting physiological responses to exercise (e.g., aspirin, acetaminophen, beta blockers, statins, stimulants, depressants, SSRIs) Tobacco or nicotine use in the past six months Current or past musculoskeletal injury impacting physical activity Study physician discretion based on any other medical condition or medication

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 26 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Dehydration and Rehydration Arm<br>Participants will complete exercise until 5% body mass loss, followed by ad libitum rehydration throughout 2 hours of recovery. | Behavioral: Fluid loss and consumption<br>* Upon 5% body mass loss, rehydration of fluid lost to sweating throughout a 2 hour recovery period<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Multitasking test | Accuracy score of a multitasking test (0-100%) with greater scores indicating a better outcome | Upon completion of 5% body mass loss protocol, approximately 2 hours into the trial | 
| Multitasking test | Accuracy score of a multitasking test (0-100%) with greater scores indicating a better outcome | 2 hours following the dehydration cognitive function test, approximately 4.5 hours into the trial |