Treatment Of Shallow Periodontal Pockets Using PRF As an Adjunct To Scaling And Root Planing In Periodontitis Patients

Study Overview
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Brief Summary
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Platelet rich fibrin (PRF) has been widely used in regenerative dentistry since it provides plenty amount of growth factors that enhance wound healing and tissue regeneration. Platelet derived growth factor-BB (PDGF-BB) is a growth factor with essential functions such as regulation of cell migration, proliferation, and differentiation. This study aims to evaluate the efficacy of PRF in improving the clinical periodontal parameters and GCF level of PDGF-BB.

Detailed Description
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Split mouth randomized clinical trial is the design of the study. 12 periodontitis patients with 24 opposite shallow periodontal pockets (4-6 mm in depth) will be selected. Randomization in this study will be achieved using toss of coin method in which periodontal pockets will be designated either control site or test site. PRF will be used as an adjunct to scaling and root planing to treat the test sites. While control sites were treated by scaling and root planing only. Clinal periodontal parameters were recorded and GCF level of PDGF-BB will be measured at baseline and1- and 3- month follow-up visits to evaluate the healing response to the treatment.

Official Title
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Treatment Of Shallow Periodontal Pockets Using PRF As an Adjunct To Scaling And Root Planing In Periodontitis Patients, Randomized Clinical Trial

Conditions
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Periodontitis

Intervention / Treatment
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* Other: PRF


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: •periodontitis Exclusion Criteria: Periodontal therapy for the last 3 months Medical history of systemic diseases such as diabetes. Patients wearing dental prosthesis Alcoholic patients Teeth with grade II mobility, endodontic lesions, and teeth with untreated caries

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Test ScRp+PRF<br>This site will treated by ScRp+PRF | Other: PRF<br>* Split mouth randomized clinical trial will be the design of the study. 12 periodontitis patients with 24 opposite shallow periodontal pockets (4-6 mm in depth) will be selected. Randomization in this study will be achieved using toss of coin method in which periodontal pockets were designated either control site or test site. PRF will be used as an adjunct to scaling and root planing to treat the test sites. While control sites will be treated by scaling and root planing only. Clinal periodontal parameters will be recorded and GCF level of PDGF-BB will be measured at baseline and1- and 3- month follow-up visits to evaluate the healing response to the treatment.<br>|
| No Intervention: Control ScRp<br>This site will treated by ScRp only | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Clinical attachment level | Using UNC-15 periodontal probe measured in mm | Change from baseline to 1-month and change from baseline to 3-month | 
| Change in Periodontal pocket depth measured in mm | Using UNC-15 periodontal probe measured in mm | Change from baseline to 1-month and change from baseline to 3-month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in plaque index | Using Sinless and Loe 1964 plaque index scores | Change from baseline to 1-month and change from baseline to 3-month | 
| Change in bleeding on probing percentage | Using UNC-15 periodontal probe | Change from baseline to 1-month and change from baseline to 3-month | 
| Change in GCF level of platelet derived growth factor | Using periocol paper to collect GCF and analysed by ELISA test | Change from baseline to 1-month and change from baseline to 3-month |