New Interactive Sensor-home-based Hand Training to Improve Dexterity

Study Overview
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Brief Summary
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Primary objective of this study is to explore the impact of a 3-week upper limb hand function training in patients with PD, MS or stroke. The benefits on hand function of this training program will be evaluated. The hypothesize is that the 3-week upper limb hand function training improves finger dexterity.

Detailed Description
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Patients with Parkinson's disease (PD), multiple sclerosis (MS) or stroke often suffer from significantly decreased coordination and have difficulties with precise hand/finger movements during the performance of both basic activities of daily living (ADL), such as dressing, grooming as well as higher ADL, such as cooking, shopping and regular medication intake. The investigators explore the effects of a new, interactive, sensor-home-based upper limb hand training on upper limb related ADL in patients with PD, MS or stroke.

Official Title
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New Interactive Sensor-home-based Hand Training to Improve Dexterity

Conditions
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Stroke, Multiple Sclerosis, Parkinson Disease

Intervention / Treatment
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* Device: smart sensor egg training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with confirmed PD, according to UK Brain bank Criteria (Hughes et al., 1992) or MS patients with relapsing-remitting MS (RRMS), secondary-progressive MS (SPMS) or primary progressive MS (PPMS) according to the revised McDonald's criteria or subacute stroke written and signed informed consent self-reported hand function problems or healthy subject written and signed informed consent no self-reported hand function problems Exclusion Criteria: MoCA <21/30 psychiatric disease participation on other interventional trials Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: sensor-home-based hand training for MS, PD, stroke or control group
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: smart sensor egg training<br>An interactive hand trainer with integrated sensors was developed and can be used as input devices to a training which runs on the smartphone or tablet computer to train different finger, hand, and wrist functions. | Device: smart sensor egg training<br>* The portable hand trainer has three principal functionalities: (I) Grasping, (II) Pronosupination, and (III) wrist and finger extension. Different exercises can be done.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hand dexterity | Nine Hole Peg test (9-HPT): The 9-HPT is a standardized, well established, and reliable measure of hand dexterity in patients with PD, MS, or stroke. seconds will be measured. | 3 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fine finger movements | Coin rotation task (CRT): The CRT measures fine coordinated finger movements and is a suitable and valid dexterity test in patients with PD, MS, or stroke. The seconds for 20 halfturns will be measured. | 3 weeks | 
| grip strength | The handheld JAMAR dynamometer measures the grip strength. kg will be measured. | 3 weeks | 
| cognition | Montreal Cognitive Assessment (MOCA): Cognitive screening tool with a scale from 0 - 30 points. A higher score means a better outcome. | baseline | 
| executive function | Trail Making Tests (TMT) parts A & B. Results for both TMT A and B are reported as the number of seconds required to complete the task; therefore, higher scores reveal greater impairment. | 3 weeks | 
| executive function | Stroop-test: Results are reported as the number of seconds required to complete the task; therefore, higher scores reveal greater impairment. | 3 weeks | 
| self-reported dexterity related problems in daily living for PD | Patients with PD: Dexterity Questionnaire 24 (DextQ-24): This questionnaire is a standardized patient self-rated outcome measure (PROM) for evaluating dexterity related ADL in PD. score range 24-96, higher scores mean more dexterity problems. | 3 weeks | 
| self-reported arm and hand function related problems in patients with MS | Patients with MS: The Arm Function in Multiple Sclerosis Questionnaire (AMSQ): This questionnaire is a standardized patient self-rated outcome measure (PROM) for evaluating arm and hand function in patients with MS. Containing 31 items with a range of 1 - 100 points. Higher scores indicate more limitations in hand and arm function. | 3 weeks | 
| Arm and hand function in stroke patients | Patients with stroke: Upper limb limos: Mesures arm and hand function in ADL. | 3 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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dexterity, training