Effect of Acetaminophen Preemptive Analgesia on Postoperative Cognitive Function

Study Overview
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Brief Summary
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Patients undergoing gastrointestinal tumor surgery are prone to delayed recovery and postoperative cognitive dysfunction due to greater trauma and longer operation time. Pre-analgesia can reverse the effects of nociceptive stimulation on recovery from general anesthesia and postoperative cognitive function. Intravenous injection of non-steroidal drugs can effectively reduce postoperative pain and the use of opioids. Therefore, This study selected acetaminophen mannitol injection for preemptive analgesia to observe the effects on anesthesia recovery time and postoperative cognitive function of patients undergoing gastrointestinal tumor surgery, providing new ideas for reducing cognitive dysfunction in patients undergoing gastrointestinal tumor surgery

Detailed Description
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By administering acetaminophen to patients with gastrointestinal tumors before surgery, recording the time to recovery from anesthesia, and assessing cognitive function status by CAM on the first, third, and seventh day after surgery

Official Title
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Effects of Acetaminophen Preemptive Analgesia on Anesthesia Recovery Time and Postoperative Cognitive Function in Patients Undergoing Gastrointestinal Tumor Surgery

Conditions
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Cognitive Function

Intervention / Treatment
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* Drug: acetaminophen mannitol
* Drug: Normal saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing gastrointestinal tumor surgery American Society of Anesthesiologists（ASA）≤Ⅲ Exclusion Criteria: History of severe adverse reactions to oral acetaminophen Dysfunction of heart, liver, kidney and other important organs History of chronic pain Oral non-steroidal or opioid drugs Patients who do not accept clinical trials

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 88 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: By applying acetaminophen mannitol to patients with gastrointestinal tumors before surgery<br>Acetaminophen mannitol injection 50ml(500mg) intravenously pumped 30 minutes before surgery | Drug: acetaminophen mannitol<br>* Intravenous acetaminophen was administered 30 minutes before anesthesia<br>|
| Placebo Comparator: By applying normal saline to patients with gastrointestinal tumors before surgery<br>Normal saline injection 50ml intravenously pumped 30 minutes before surgery | Drug: Normal saline<br>* Intravenous acetaminophen was administered 30 minutes before anesthesia<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative delirium | The confusion assessment method (CAM) was used to assess postoperative cognitive dysfunction | 1/3/7 days after the surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recovery time | The postoperative recovery time was recorded | immediately after the surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acetaminophen mannitol, cognitive function, anesthesia recovery time, gastrointestinal tumor surgery