Magnesium Injection Ensures Steroid Avoidance During Vaccine, Viremia or Immunocompromise

Study Overview
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Brief Summary
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Steroid injections are used for interventional pain management. However, their side-effect of immunosuppression may increase the risk of infections. Magnesium is an alternative anti-nociceptive injection that may be used instead of steroids. Prospective observational study of patients who received magnesium injection for interventional pain therapy, instead of steroid injection. Post-injection data collection includes numerical rating pain score, and sleep quality score. Pain is measured using the numeric pain rating scale. Sleep score is measured using the Likert sleep scale. A change in the pain or sleep scores by 2-points is considered significant.

Detailed Description
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Corticosteroid injections are used for interventional pain management. The immunosuppression effect of steroid injection may increase the risk of infections. Magnesium is an alternative anti-nociceptive agent that may be used for interventional pain injection therapy, instead of steroids. Prospective observational clinical study of pain clinic patients who received magnesium injection for interventional pain therapy, instead of steroid injection. Post-injection data collection includes numerical rating pain score, and sleep quality score. Pain is measured using the numeric pain rating scale. Sleep score is measured using the Likert sleep scale. A change in the pain or sleep scores by 2-points is considered significant. Data analyzed with IBM® SPSS® Statistics 25 (IBM Corp, Armonk, NY); using Student's t-test, ANOVA, Pearson Chi-square test, and regression analysis. P-value <0.05 is considered significant.

Official Title
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Magnesium Injection Ensures Analgesia and Steroid Avoidance During Vaccination, Viremia or Immunocompromise

Conditions
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Steroid Metabolism Disorder

Intervention / Treatment
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* Drug: Magnesium


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: adult chronic pain patients previous interventional injection therapy consent for interventional injection therapy good treatment compliance regular sleep diary regular pain diary informed consent for diary review consent for clinical record quality assurance review Exclusion Criteria: organ insufficiency cognitive disorder inability to provide consent major neuropsychiatric disorder unreliable diary poor treatment compliance previous adverse/allergic reactions to magnesium

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Adult chronic pain patients<br>Cohort of adult chronic pain patients, undergoing interventional injection therapy for pain management at a Canadian pain clinic | Drug: Magnesium<br>* Magnesium injection therapy<br>* Other names: Magnesium injection;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain score, objective measurement using the validated Numeric Pain Rating scale | Pain score, using the Numeric Pain Rating scale of 0 to 10, low scores indicate less pain, high scores indicate worse pain | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sleep quality score, objective measurement using the validated Likert sleep scale | Sleep quality score, using the Likert sleep scale of 0 to 10, low scores indicate poor sleep, high scores indicate better sleep | 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Magnesium, Steroid avoidance