linjc16/ctgov huggingface dataset:
Genderspecific Differences in Hormone Levels After Trauma

Study Overview
=================
Brief Summary
-----------------
The goal of this prospective study with the aim to establish a registry is to learn about the role of steroid hormones in severely injured patients. The main question it aims to answer is whether steroid hormones influence morbidity and mortality after severe trauma. This is a prospective study with the aim to establish a large registry for severely injured patients and their hormonal status. Hormone levels will be measured upon arrival in the emergency room and within the following few days after trauma. Furthermore a detailed questionnaire aims to answer any hormone-related health questions.

Official Title
-----------------
A Prospective Analysis of the Gender Specific Role of Steroid Hormones on the Outcome on Patients After Polytrauma

Conditions
-----------------
Polytrauma

Intervention / Treatment
-----------------
* Other: No interventions are planned


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Polytrauma with ISS≥16, severe traumatic brain injury (AIS ≥3) over the age of 18 must reach emergency room alive Exclusion Criteria: pregnant patients dead on arrival to the hospital incarcerated patients secondarily transferred patients

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: No interventions are planned|No interventions are planned|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality |  | within 1 year after trauma |
Inhibition of Che-1/AATF as a New Tool in Multiple Myeloma Treatment

Study Overview
=================
Brief Summary
-----------------
Multiple myeloma (MM) is a haematological malignancy characterized by the accumulation of proliferating antibody producing plasma cells in the bone marrow. In the last few years many studies have emphasized the biological complexity and heterogeneity of MM as a result of both genetic and epigenetic aberrations. Che-1/AATF (Che-1) is a transcriptional cofactor involved in cell cycle regulation, apoptosis, DNA damage and stress response. it can be hypothesized that Che-1 might contribute to the establishment of the MM malignant phenotype by sustaining global transcription through its ability to modulate chromatin accessibility. The prospective study on MM human samples aims to understand the involvement of Che-1 in the transcriptional regulation and chromatin remodeling during the pathology. To this goal the main objectives are: Characterization of Che-1's role in chromatin remodeling and global gene expression Study in vivo and in vitro of Che-1 involvement in MM tumorigenesis Evaluation of Che-1 as a possible therapeutic target

Official Title
-----------------
Inhibition of Che-1/AATF as a New Tool in Multiple Myeloma Treatment

Conditions
-----------------
Multiple Myeloma

Intervention / Treatment
-----------------
* Other: ATAC-seq and ChIP-seq


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: MM Patients Exclusion Criteria: No exclusion criteria
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: ATAC-seq and ChIP-seq|CD138+ cells will be isolated from the bone marrow of MM patients and will be subjected to ATAC-seq and ChIP-seq analyses, by useing specific antibodies, to better understand the involvment of Che-1 in MM tumorogenesis.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Che-1 involvement in MM tumorigenesis | Characterization of Che-1's role in chromatin remodeling and global gene expression | About 2 years |
Anti KU Antibodies and Its Relationship With Systemic Lupus Erythematosus

Study Overview
=================
Brief Summary
-----------------
systemic lupus Erythematosus (SLE) is a multi system autoimmune disorder abroad spectrum of clinical presentations. Diagnosis of SLE depending on Systemic Lupus International Collaborating Clinics (SLICC) Criteria. SLICC Criteria requires either that a patient satisfy at least 4 of 17 Criteria including at least 1 of 11 clinical criteria and 1 of 6 immunological criteria or the patient has biopsy -proven nephritis compatible with SLE in the presence of antinuclear antibodies (ANA)or anti_double stranded DNA (dsDNA) antibodies. Anti_KU antibodies included in (ANA), reported in many autoimmune disorders like SLE,Sjogren syndrome, idiopathic lung fibrosis and myositis. So the aim of the work is to determine the relationship between Anti_KU antibodies and SLE manifestations.

Official Title
-----------------
Anti KU Antibodies and Its Relationship With Systemic Lupus Erythematosus

Conditions
-----------------
Systemic Lupus Erythematosus

Intervention / Treatment
-----------------
* Diagnostic Test: Anti _KU antibodies


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all patients will fulfill the Systemic Lupus International Clinics(SLICC) classification criteria for Systemic Lupus Erythematosus. Exclusion Criteria: any patient with any collagen disease other than SLE

Ages Eligible for Study
-----------------
Minimum Age: 17 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Anti _KU antibodies|aim of the work is to determine the relationship between Anti_Ku antibodies and SLE manifestations the study will include 60 SLE cases diagnosed by SLICC criteria and the activity of SLE will be calculated by SELDAI criteria, which is tool composed of 24 clinical and laboratory variables.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anti KU antibodies and its relationship with Systemic Lupus Erythematosus manifestations | the study will evaluate the titre of Anti KU antibodies which is positive or negative in one patient and on the other side what is the manifestation of SLE that found in the same patient if the Anti KU Antibodies titre is positive | 6 months |
Psychological Wellbeing, Physical Activity, and Disability in Fibromyalgia

Study Overview
=================
Brief Summary
-----------------
This study aims to investigate the association between psychological wellbeing, physical activity, and disability in patients with fibromyalgia. Participants will complete self-reported questionnaires to assess psychological wellbeing, physical activity, and disability. The study will use descriptive statistics, correlation analysis, and multiple regression analysis to analyze the data.

Official Title
-----------------
The Relationship Between Psychological Wellbeing, Physical Activity, and Disability in Patients With Fibromyalgia: A Cross-Sectional Study

Conditions
-----------------
Fibromyalgia

Intervention / Treatment
-----------------
* Other: no intervention - cross-sectional observational only


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of fibromyalgia Age between 18 and 70 years old Exclusion Criteria: Unable to complete self-reported questionnaires Presence of other chronic pain conditions

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Fibromyalgia patients<br>Participants will complete self-reported questionnaires to assess psychological wellbeing, physical activity, and disability. | Other: no intervention - cross-sectional observational only<br>* no intervention - cross-sectional observational only<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Depression, Anxiety, and Stress Scale (DASS) | epression, Anxiety, and Stress Scale (DASS) is a self-report questionnaire that is used to assess the severity of depression, anxiety, and stress. The DASS consists of 42 items that are scored on a scale of 0 to 3, with 0 indicating not at all and 3 indicating severely. The total score for the DASS is the sum of the scores for the 42 items. A higher score indicates more severe symptoms of depression, anxiety, or stress. | Baseline | 
| International Physical Activity Questionnaire (IPAQ) | International Physical Activity Questionnaire (IPAQ) is a self-report questionnaire that is used to assess physical activity levels. The IPAQ consists of 7 questions that ask about the frequency, duration, and intensity of physical activity. The IPAQ can be used to assess physical activity levels in people of all ages and activity levels. | Baseline | 
| Fibromyalgia Impact Questionnaire (FIQ) | is a self-report questionnaire that is used to measure disability in patients with fibromyalgia. The FIQ consists of 21 items that ask about the impact of fibromyalgia on physical function, social function, and role function. The FIQ can be used to assess the severity of fibromyalgia and to monitor the effectiveness of treatment. | Baseline |
NC/TMD Ratio as a Difficult Airway Predictor in Obese Patients

Study Overview
=================
Brief Summary
-----------------
To assess accuracy of NC/TM distance ratio in terms of sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) for predicting difficult intubation in obese patient with Intubation difficulty score (IDS) as gold standard.

Detailed Description
-----------------
At Preanaesthesia clinic patients , neck circumference to Thyromental distance ratios of obese patients with BMI >30Kg/m2 will be calculated and patients will be divided into two groups on the basis of Nc/TMD ratio as anticipated easy intubation ( NC/TMD<5) And anticipated difficult intubation ( NC/TMD ≥5). Intra-operatively, patients Intubation difficulty scale score will calculated and the data obtained from IDS score will be compared with NC/TMD ratio as a predictor of difficult Intubation and diagnostic accuracy of NC/TMD as a reliable indicator of difficult intubation in obese patients will be calculated by statistical analysis.

Official Title
-----------------
Neck Circumference to Thyromental Distance Ratio as a Reliable Indicator for Predicting Difficult Intubation in Obese Patients for Elective Surgery Under General Anesthesia

Conditions
-----------------
Difficult / Failed Intubation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ASA physical status I to III Body Mass Index (BMI) of 30kg/m2 or more age 18-65 years Exclusion Criteria: non consenting ASA class greater than III, patients undergoing general anesthesia without tracheal intubation or under regional anesthesia, patients with upper airway pathology such as maxillofacial fractures, upper airway tumors or cervical spine fracture, obstetric patients, refusal of the patient, previous head and neck surgery or radiotherapy.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group A (predicted easy intubation)<br>Group A labelled as predicted easy intubation on the basis of NC/TM distance ratio <5 | |
| Group B (predicted difficult intubation)<br>Group B labelled as predicted Difficult intubation on the basis of NC/TM distance ratio ≥ 5 | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Predictability of difficult airway | At the preanaesthetic examination neck circumference to thyromental distance ratio will be caculated in obese patients with BMI ≥ 30KG/m2 and the predictability of difficult airway will be evaluated by statistical analysis | During anaesthesia induction | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
difficult intubation, NC/TM distance ratio, intubation difficulty score
Passive Transmission of COVID-19 Antibody From Mother to Infant

Study Overview
=================
Brief Summary
-----------------
At present, there is no relevant research focusing on children's acquisition of novel coronavirus antibodies through maternal passive transmission. Therefore, this study assessed the changes of maternal passive transmission of COVID-19 antibodies by monitoring the specific antibodies of COVID-19 in young children; This will lay a foundation for further exploring the risk of COVID-19 infection in children and formulating immune prevention strategies.

Official Title
-----------------
Children's Hospital of Chongqing Medical University

Conditions
-----------------
Passive Transmission of Maternal and Infant Antibodies

Intervention / Treatment
-----------------
* Biological: sars-cov-2 vaccine or infection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children aged 0-2; No history of blood transfusion, chemotherapy, or related immunosuppressive therapy; No immune system related diseases; Exclusion Criteria: Not willing to participate

Ages Eligible for Study
-----------------
Minimum Age: 0 Months
Maximum Age: 2 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control group 1<br>Mother not vaccinated with COVID-19 vaccine | Biological: sars-cov-2 vaccine or infection<br>* Whether to vaccinate COVID-19 vaccine, or infect with sars-cov-2<br>|
| Control group 2<br>The mother was vaccinated with COVID-19 vaccine before pregnancy, and was not infected during pregnancy | Biological: sars-cov-2 vaccine or infection<br>* Whether to vaccinate COVID-19 vaccine, or infect with sars-cov-2<br>|
| Control group 3<br>The mother was vaccinated with COVID-19 vaccine before pregnancy, and was infected during pregnancy | Biological: sars-cov-2 vaccine or infection<br>* Whether to vaccinate COVID-19 vaccine, or infect with sars-cov-2<br>|
| Experimental group<br>The mother was not vaccinated with COVID-19 vaccine before pregnancy, so she was infected during pregnancy | Biological: sars-cov-2 vaccine or infection<br>* Whether to vaccinate COVID-19 vaccine, or infect with sars-cov-2<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SARS-CoV-2 IgG | ELISA detection of SARS-CoV-2 IgG antibody levels | duration of time over which each participant could be 6-month to 12-month | 
| SARS-CoV-2 neutralizing antibody | detection the level of SARS-CoV-2 neutralizing antibody | duration of time over which each participant could be 6-month to 12-month |
Comparative Study of the Performance of Drug Anamneses in an Emergency Department

Study Overview
=================
Brief Summary
-----------------
After the first medical history by the nurse and the emergency physician, the pharmacist and the pharmacy assistant take a detailed history of the patient's medications separately. After checking with the patient's reference pharmacy, the pharmacist and pharmacy assistant compare their results.

Official Title
-----------------
Comparative Study Between a Pharmacy Technician and a Pharmacist in the Performance of Medication Anamneses in Emergency Departments: a Skills Validation Study

Conditions
-----------------
Medication Adherence

Intervention / Treatment
-----------------
* Other: Emergency Care Unit - medicines


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Admission to the emergency care unit Over 18 years old Giving consent to participate Exclusion Criteria: Patients who do not take medication daily Unconscious patients

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Urgent care unit patients with medication<br>All patients admitted to the emergency department who agree to describe their medication | Other: Emergency Care Unit - medicines<br>* The same group of patients admitted to the emergency room will respond separately to a pharmacist and a pharmacy assistant about their daily medication. The two medical records will be compared in order to evaluate the work of the pharmacy assistant on the basis of 3 sources : the Electronic Medical Record the patient's medication history the reference pharmacy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of identical medication anamneses between pharmacist and pharmacy assistant | A pharmacist and a pharmacy assistant will compare the medication history of all patients who meet the eligibility criteria | immediately after admission to the emergency department |
Italian Lung Cancer Observational Study

Study Overview
=================
Brief Summary
-----------------
LUCENT is an observational study focused on malignant pulmonary and tracheo-bronchial disease. It involves a large proportion of reference Italian thoracic surgery centers. The relevance of the study is related to the epidemiology of lung cancer in the world - also known as Big Killer - and the high mortality rates both in males and females. The aim of his prospective study is to collect a large bulk of postoperative patients' outcome data and to produce up-to-date descriptive statistics of patients undergoing surgery for lung cancer. These results will be pivotal to compare the clinical results of all the relevant specialities involved in the care of lung cancer such as medical oncologists and radiation oncologists.

Official Title
-----------------
Italian Lung Cancer Observational Study

Conditions
-----------------
Lung Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with lung cancer informed consent Exclusion Criteria: alcohol or drug abuse age < 18 inability to express consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Lung cancer surgery outcomes | Benchmarking national outcome data of the treatment of lung cancer | 5 years |
Different Algorithm Models to Predict Postoperative Pneumonia in Elderly Patients

Study Overview
=================
Brief Summary
-----------------
The researchers aim to compare different algorithms to predict postoperative pneumonia in elderly patients and to assess the risk of pneumonia in elderly patients.

Detailed Description
-----------------
Postoperative pneumonia is a common complication that increases the mortality and length of older patients. In order to better assess the risk of postoperative pneumonia in elderly patients, we plan to use database information and different algorithms, such as logistic regression, random forest, and other algorithms respectively to build models and evaluate the effects of the models.

Official Title
-----------------
Different Algorithm Models to Predict Postoperative Pneumonia in Elderly Patients

Conditions
-----------------
Postoperative Pulmonary Complications

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 65 years or older receiving invasive ventilation during general anesthesia for surgery Exclusion Criteria: preoperative mechanical ventilation procedures related to a previous surgical complication a second operation after surgery organ transplantation discharged within 24 hours after surgery cardiac and thoracic surgery

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Training set<br>The whole cohort is randomly assigned to a training cohort and validation cohort. | |
| validation set<br>The whole cohort is randomly assigned to a training cohort and validation cohort. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative pulmonary complications |  | within one week after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative pulmonary complications |  | 30 days after surgery |