Effects of Prehabilitation on Postoperative Recovery

Study Overview
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Brief Summary
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The study to be carried out in the Istanbul Faculty of Medicine Department of Anesthesiology was planned as a randomized, prospective study. Patients who will undergo lung resection will be included in the study. Patients were randomized into two groups: Intervention Group includes patients who are rehabilitated preoperatively (prehabilitation), Control Group includes patients who are routinely recommended preoperative exercise, alcohol and smoking cessation. Prehabilitation consists of respiratory muscle exercise and walking is recommended to Intervention Group. Postoperative recovery will be questioned with Quality of Recovery-15 (QoR-15) on the 2nd day and 1st month. The intensive care unit admission, postoperative pulmonary complications and length of hospital stay will be recorded.

Detailed Description
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The study to be carried out in the Istanbul Faculty of Medicine Department of Anesthesiology was planned as a randomized, prospective study. Patients who will undergo lung resection will be included in the study. Patients will be informed about the study and their written consent will be obtained. Patients who do not give consent will not be included in the study. Routine preoperative evaluation including detailed history (daily physical activity, clinical complaints at rest or exertion, if any) and physical examination will be performed on the patients. Patients were randomized into two groups: Intervention Group includes patients who are rehabilitated preoperatively (prehabilitation), Control Group includes patients who are routinely recommended preoperative exercise, alcohol and smoking cessation. Preoperative exercise, alcohol and smoking cessation are recommended to all patients. Prehabilitation consists of respiratory muscle exercise with inspiratory muscle trainer (two times a day) and walking (5000steps/day) is recommended to Intervention Group. Hospitalized patients are followed up with daily visits, and patients who are at home are followed up by phone call. All patients' induction of anesthesia and maintenance were similar. Postoperative recovery will be questioned with Quality of Recovery-15 (QoR-15) on the 2nd day (as primary outcome) and 1st month. The duration of anesthesia, surgery duration, intensive care unit admission, postoperative pulmonary complications and length of hospital stay will be recorded.

Official Title
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Effects of Prehabilitation on Postoperative Recovery in Patients Undergoing Lung Resection

Conditions
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Lung Cancer

Intervention / Treatment
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* Other: Respiratory muscle exercise
* Other: Endurance exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA physical status classification system score 1-3 patients Patients who underwent lung resection Patients who agreed to participate in the study and gave written informed consent Exclusion Criteria: Re-operation Emergency operations Patients with psychiatric drug use unability for physical exercise

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: randomized, prospective
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br>Preoperative exercise, alcohol and smoking cessation are recommended to patients. | |
| Active Comparator: Intervention<br>Respiratory muscle exercise (two times a day) and walking (5000steps/day) are recommended to the patients preoperatively. | Other: Respiratory muscle exercise<br>* respiratory muscle exercise with inspiratory muscle trainer (two times a day)<br>Other: Endurance exercise<br>* walking exercise 5000 steps/day<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of recovery at postoperative second day | The primary aim of our study is to compare recovery of patients who have prehabilitation programme and who have not any programme by using QoR-15 questionnaire on the 2nd postoperative day. | two days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of recovery at postoperative first month | Investigating recovery of patients by by using QoR-15 questionnaire | one month | 
| length of intensive care unit stay | Investigating planned or unplanned ICU admission | two weeks | 
| Length of hospital stay | patients' length of stay | one month | 
| Postoperative pulmonary complications | Patients' pulmonary complications such as pneumonia, atelectasis, hemorrhage, emphysema, prolonged air leak, chylothorax and respiratory failure. | one month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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prehabilitation, quality of recovery, lung resection