Tissue Oxygen Use With Combined Arteriovenous Noninvasive Oximetry

Study Overview
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Brief Summary
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The goal of this observational study is to find out if researchers can measure oxygen consumption in the body without having to draw blood from lines in arteries and central veins. Participants will undergo measurements of arterial blood oxygen saturation using both finger and neck pulse oximeters.

Detailed Description
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TOUCAN-1 is a study to estimate the accuracy and precision of pulse oximetry as a noninvasive tool for oxygen consumption measurement. Researchers will use a pair of commercially-available, noninvasive pulse oximeters to estimate the oxygen saturation of blood in the internal jugular vein, and compare it to the directly measured oxygen saturation in sampled jugular blood. Researchers will then measure the arterial oxygen saturation in a finger, and compare it to the directly measured oxygen saturation in sampled radial arterial blood.

Official Title
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Tissue Oxygen Use With Combined Arteriovenous Noninvasive Oximetry (TOUCAN-1): Determining the Precision and Accuracy of Combined Finger Pulse Oximetry and Jugular Transreflectance Oximetry to Estimate Global Oxygen Use

Conditions
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Oxygen Consumption

Intervention / Treatment
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* Device: Finger pulse oximetry probe
* Device: Transreflectance oximetry probe


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Inpatient at the University of Wisconsin University Hospital Has an internal jugular venous central line Has a radial arterial line Exclusion Criteria: Currently receiving extracorporeal membrane oxygenation (ECMO) Currently receiving continuous renal replacement therapy (CRRT/CVVH) All usable lumens of the participant's jugular catheter are in use, and interruption of any medical or therapy through any lumen would, in the view of the primary care team, compromise the participant's care. Jugular venous catheter is not functional or position is not confirmed by radiography Arterial cannula is not functional Known history of sickle cell anemia or other hemoglobinopathy Therapy with any of the following medications: Nitroprusside Hydroxocobalamin Indocyanine green Norepinephrine Vasopressin Epinephrine Any other medication or therapy that, in the judgement of the study investigators, may affect the accuracy and precision of the noninvasive oximetry results

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Critically ill adults<br>Inpatient adults who require internal jugular venous central line and radial arterial line | Device: Finger pulse oximetry probe<br>* This finger probe will be used to make noninvasive measurements of systemic arterial and central venous oxygen saturations.<br>Device: Transreflectance oximetry probe<br>* This neck probe will be used to make noninvasive measurements of systemic arterial and central venous oxygen saturations.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Accuracy of digital pulse oximetry | Difference in the standard deviation of the arteriovenous saturation difference comparing noninvasive photoplethysmography to invasive blood sampling and oximetry | Through study completion, approximately 20 minutes | 
| Accuracy of jugular pulse oximetry | Difference in the standard deviation of the arteriovenous saturation difference comparing noninvasive photoplethysmography to invasive blood sampling and oximetry | Through study completion, approximately 20 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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jugular vein catheter, intensive care, radial artery catheter