Concentrated Platelet Rich Fibrin (C-PRF) as Adjunct to Non-surgical Periodontal Therapy

Study Overview
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Brief Summary
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The current study is a prospective randomised split mouth study to evaluate the effect of concentrated Platelet Rich Fibrin as an adjunct to the scaling and root planing

Detailed Description
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Twelve healthy individuals satisfying the inclusion and exclusion criteria were recruited for the study. A detailed, thorough medical and dental history was obtained and each patient was subjected to comprehensive clinical and radiological examination. All patients were informed about the nature of the study, procedure involved, potential benefits and risks associated with procedure and written informed consent were obtained from all patients. All the patients underwent scaling and root planing. As it is split mouth study design the test site is treated with Concentrated platelet rich fibrin( C-PRF) and the contralateral site is not treated with C-PRF. Periodotal pack was placed and patient was recalled after 6 weeks for the follow up.

Official Title
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Concentrated Platelet Rich Fibrin (C-PRF) as Adjunct to Non-surgical Periodontal Therapy- a Split Mouth Randomized Clinical Trail

Conditions
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Periodontal Pocket

Intervention / Treatment
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* Biological: C-PRF


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient age ranging from 18-45 years Contralateral sites with probing depth 5mm-7mm associated with premolar and molar teeth with no furcation involvement No systemic disease Not under any medication which effect the outcome of periodontal therapy Exclusion Criteria: History of any periodontal therapy within past 6 months Pregnant and lactating mothers Smokers smoking >10 cigarettes per day Patients with blood disorders or platelet count less than 50000 cells/ µL Patients with known systemic disease Non-compliant patients

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Probing sites with SPR and C-PRF application<br>The test group received the C-PRF as adjunct to sacling and root planing | Biological: C-PRF<br>* thorough scaling and root planing is performed followed by withdraw of 5ml of blood from antecubital vein of patient with consent . Following C-PRF protocol of 3000rpm for 8 min centrifugation is performed. 1ml of plasma is drawn from the test tube just above the red blood cell layer and allowed to clot and the formed clot is placed in the periodontal pocket after scaling and root planing<br>* Other names: Concentrated platelet rich fibrin;|
| No Intervention: Probing sites with SPR alone<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Probing pocket Depth | measured using a UNC-15 probe (university of North Carolina-15 periodontal probe- Hu-Friedy, Chicago, IL, USA) | 6 weeks | 
| Relative attachment level | measured by placing the acrylic stent on the selected teeth using UNC-15 probe (university of North Carolina-15 periodontal probe- Hu-Friedy, Chicago, IL, USA) | 6 weeks |