linjc16/ctgov huggingface dataset:
Glaukos® iStent Infinite Trabecular Micro-Bypass System in Subjects With Mild to Moderate Primary Open-angle Glaucoma

Study Overview
=================
Brief Summary
-----------------
Prospective, multicenter, single-arm study of the iStent infinite in adult pseudophakic or phakic subjects with mild to moderate primary open angle glaucoma who have not failed conventional medical and surgical treatment

Official Title
-----------------
A Prospective, Multicenter Study of the Glaukos® iStent Infinite Trabecular Micro-Bypass System Model iS3 in Subjects With Mild to Moderate Primary Open-angle Glaucoma

Conditions
-----------------
Glaucoma

Intervention / Treatment
-----------------
* Device: iStent Infinite


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of primary open-angle glaucoma Phakic or pseudophakic Age 35 years or older Exclusion Criteria: Traumatic, uveitic, neovascular, angle-closure glaucoma or glaucoma associated with vascular disorders Active corneal inflammation or edema Retinal disorders not associated with glaucoma

Ages Eligible for Study
-----------------
Minimum Age: 35 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: iStent Infinite<br>iStent Infinite Trabecular Micro-Bypass System | Device: iStent Infinite<br>* iStent Infinite Trabecular Micro-Bypass System<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean Diurnal Intraocular Pressure (IOP) 12-Month reduction ≥ 20% from Baseline |  | 12 Months |
Comparison of Erector Spina Plane Block and Lumbar Plexus Block in Femoral Fracture Surgery

Study Overview
=================
Brief Summary
-----------------
The aim is to clinical trials compare the lumbar plexus block method with the erector spinae plan block method in terms of analgesic efficacy and possible complications. İn patients for femur fracture surgery. The main questions it aims to answer are: 1. is erector spinae plane block as effective as lumbar plexus block for postoperative analgesia in femur fractures? 2. Is erector spinae plane block effective for reducing opioid consumption compared to lumbar plexus block?

Official Title
-----------------
Comparison of Erector Spina Plane Block and Lumbar Plexus Block for Postoperative Analgesia in Femoral Fracture Surgery

Conditions
-----------------
Femur Fracture, Erector Spinae, Lumbar Plexus, Ultrasound Guide

Intervention / Treatment
-----------------
* Procedure: ESP block
* Procedure: LP block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: undergoing proximal femoral surgery All patients who can respond to pain assessment questions Exclusion Criteria: With regional block contraindications, with severe cardiac and respiratory disease, with severe coagulopathy, having a body mass index greater than 35 patients will be excluded.

Ages Eligible for Study
-----------------
Minimum Age: 45 Years
Maximum Age: 95 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Group 1: The patients in the first group (ESP Group) will be applied ultrasound guided ESP block at the lateral position at the end of the surgery. ESP will be performed with a posterior approach, under ultrasound guidance, by imaging the muscles and the needle. Group 2: At the end of the surgery, patients in the second group (LP Group) will have an appropriate level of LP block with ultrasound guidance and, if necessary, using a neurostimulator.
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: ESP Block<br> | Procedure: ESP block<br>* ESP block: ultrasound guided erector spina plane block<br>|
| Active Comparator: LP block<br> | Procedure: LP block<br>* LP block: ultrasound guided lumbar plexus block<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative opioid consumption | Erector spina plan block is expected to provide effective postoperative analgesia and reduce postoperative intravenous opioid consumption in patients undergoing hip surgery. | postoperative 24 hours |
A Study to Learn About the Patients With COVID-19 Prescribed Paxlovid in Morocco

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to collect information on the: general information of a group of people such as their age, sex, and other facts. clinical information of the patients such as any other illness before having COVID 19. In adult patients with COVID-19 who have been prescribed nirmatrelvir and ritonavir treatment. This study will be conducted in Morocco. The study will capture information of the adult COVID-19 outpatients and inpatients who have been prescribed nirmatrelvir, ritonavir treatment. The inpatients will be admitted in the hospital for other reasons than COVID-19. This study will have about 150 patients. The study will involve collection of patient information from medical records. The information collected can be either from papers or from computers. The study will include patient information of those who: are confirmed to have COVID-19 infection during the study period from 01 June 2022 to 30 June 2023. are 18 years of age or older. are prescribed Nirmatrelvir and ritonavir. This study will help to inform decision-making on use of Paxlovid at the national level.

Official Title
-----------------
A Retrospective Observational Non-Interventional Study (NIS) to Assess Patient Characteristics Among COVID-19 Patients Receiving Treatment With Nirmatrelvir/Ritonavir (PAXLOVIDTM) in Morocco.

Conditions
-----------------
COVID-19 Drug Treatment

Intervention / Treatment
-----------------
* Drug: Nirmatrelvir/Ritonavir


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Confirmed COVID-19 infection during the study period from 01 June 2022 to 30 June 2023 Nirmatrelvir, ritonavir written prescription Exclusion Criteria: There are no exclusion criteria for this study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Participants receiving Paxlovid Treatment<br>Patients administered oral Paxlovid as prescribed according to national Morocco treatment guidelines for Covid. | Drug: Nirmatrelvir/Ritonavir<br>* Patients administered oral Paxlovid as prescribed according to national Morocco treatment guidelines for Covid.<br>* Other names: Paxlovid;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Demographical Characteristics of Participants |  | Approximately 01 June 2022 through 30 June 2023 | 
| Clinical Characteristics of Participants |  | Approximately 01 June 2022 through 30 June 2023 | 
| Number of Participants with Pre-existing Comorbidites |  | Approximately 01 June 2022 through 30 June 2023 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Treatment, Covid Patient, Paxlovid, Morocco
A Comparative Study Between the Different Levels of TMJ Arthroscopy in the Management of TMJ Internal Derangement

Study Overview
=================
Brief Summary
-----------------
The temporomandibular joint (TMJ) arthroscopy has emerging role nowadays in the treatment of TMJ internal derangement with its three levels of intervention. A comparative study between the 3 levels is essential to develop a standardized selection criteria and management algorithm.

Official Title
-----------------
A Comparative Study Between the Different Levels of TMJ Arthroscopy in the Management of TMJ Internal Derangement (A Randomized Clinical Trial)

Conditions
-----------------
TMJ Disc Disorder

Intervention / Treatment
-----------------
* Procedure: three levels of TMJ arthroscopy
* Procedure: three levels of TMJ arthroscopy
* Procedure: three levels of TMJ arthroscopy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with TMJ internal derangement Wilkes III Exclusion Criteria: Medically unfit patients. Patients with TMDs secondary to malocclusion. Psychological instability. Patients operated before for other TMJ problems.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: level (I) arthroscopy (Lysis and lavage)<br> | Procedure: three levels of TMJ arthroscopy<br>* Group I: 10 patients will be treated with Lysis and lavage<br>|
| Active Comparator: level (II) arthroscopy (operative arthroscopy)<br> | Procedure: three levels of TMJ arthroscopy<br>* Group II: 10 patients will be treated with operative arthroscopy<br>|
| Active Comparator: level (III) arthroscopy (operative arthroscopy + disc repositioning and fixation)<br> | Procedure: three levels of TMJ arthroscopy<br>* Group III: 10 patients will be treated with operative arthroscopy + discopexy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mouth opening measurement | measuring the maximal interincisal opening (MIO) | 1, 3 and 6 months postoperatively |
Mindfulness Training in Adolescents With Type 1 Diabetes

Study Overview
=================
Brief Summary
-----------------
Creation of an adaptation of a mindfulness-based stress reduction mobile health application specifically designed for adolescents living with Type 1 diabetes. Aim to determine whether daily mindfulness improves anxiety symptoms in adolescents with Type 1 diabetes.

Official Title
-----------------
Mindfulness-based Stress Reduction in Adolescents With Type 1 Diabetes

Conditions
-----------------
Anxiety, Type 1 Diabetes, Quality of Life

Intervention / Treatment
-----------------
* Behavioral: Mindfulness training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of Type 1 diabetes for 6 months or longer Anxiety score of 5 or higher on the Generalized Anxiety Disorder 7-item scale Must be able to read and speak English Exclusion Criteria: Clinical diagnosis of a chronic medical condition requiring intensive daily management

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Mindfulness training mobile health application<br>Use of a mindfulness training mobile health application | Behavioral: Mindfulness training<br>* Mindfulness-training mobile health application<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anxiety Symptoms | Generalized Anxiety Disorder 7-item Score range: 0 to 21 Higher scores indicate more anxiety | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diabetes-specific quality of life | Pediatric Quality of Life Inventory 3.2 Diabetes Module Range 0 to 100 Higher scores indicate better quality of life | 12 weeks | 
| Glycemic control | HbA1c | 12 weeks |
MRI T1 Relaxation Time in Rectal Cancer

Study Overview
=================
Brief Summary
-----------------
The goal of this observational study is to learn about the T1 relaxation time and T1 relaxation time properties of the disease in people with locally advanced rectal cancer. The main question it aims to answer is: Does MRI T1 relaxation time have a high diagnostic performance in recognizing fibrosis as a complete response to neoadjuvant treatment of rectal cancer? Participants will receive standard neoadjuvant treatment and be part of the standard examination programme regarding rectal cancer.

Official Title
-----------------
MRI T1 Relaxation Times in Evaluating Neoadjuvant Treatment of Rectal Cancer

Conditions
-----------------
Rectal Cancer, Locally Advanced Rectal Carcinoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: rectal cancer, age >18 years Exclusion Criteria: contraindications for MRI (pacemaker, claustrophobia, implanted medical injectors and nerve stimulators, previous radiochemotherapy or another disease which investigator judges inappropriate for the persons continued participation.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in T1 relaxation time (ms) in the rectal cancer tumor measured in IntelliSpace-software before and after neoadjuvant radiochemotherapy. | An MRI T1 relaxation time-map is performed on each participant. The data is transferred to IntelliSpace-software for measurement and mapping. It is measured in miliseconds (ms) before and after neoadjuvant treatment. | 6 to 8 weeks. |
The Effect of Laughter Yoga on Tex Anxiety and Educational Stress

Study Overview
=================
Brief Summary
-----------------
The primary purpose of this study is to examine the effects of laughter therapy on tex anxiety and educational stress in 8th-grade students.

Official Title
-----------------
The Effect of Laughter Yoga on Tex Anxiety and Educational Stress in 8th-Grade Students

Conditions
-----------------
Laughter Therapy, Anxiety, Stress, Exam

Intervention / Treatment
-----------------
* Behavioral: laughter yoga


Participation Criteria
=================
Eligibility Criteria
-----------------
The inclusion criteria of the study were determined as being an 8th-grade student, speaking and understanding Turkish, and being able to perform daily life activities. The exclusion criteria of the study were to have undergone a surgical operation in the last three months, and to have uncontrollable blood pressure, diabetes and asthma.

Ages Eligible for Study
-----------------
Minimum Age: 13 Years
Maximum Age: 14 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: laughter yoga<br>Laughter yoga was performed face-to-face with the intervention group for 35-40 minutes twice a week and in 6 sessions in total. | Behavioral: laughter yoga<br>* laughter yoga<br>|
| No Intervention: Control group<br>No intervention was performed for the control group | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Westside Test Anxiety Scale | The Westside Test Anxiety Inventory is a ten-item scale in a single dimension that aims to measure test anxiety. The scale was developed to be used in examining the effect of a program to reduce test anxiety. | up to 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Educational stress | It is a self-reported 5-point Likert-type measurement tool consisting of 16 items. The educational stress scale consists of four sub-dimensions: work pressure, course load, success anxiety, and expectation versus hopelessness. In addition to the sub-dimensions in the scale, the total score for the overall scale is calculated. | up to 6 weeks |
A Retrospective Analysis of Incisional Hernia Repair's Postoperative Recurrence

Study Overview
=================
Brief Summary
-----------------
ABSTRACT Purpose：A retrospective study was conducted among patients with incisional hernia in our hospital to analyse the factors associated with postoperative recurrence of abdominal wall incisional hernia. Methods：Patients with a diagnosis of incisional hernia obtained from our hospital's electronic medical record system were divided into primary incisional hernia group and recurrent incisional hernia group according to whether or not they had a recurrence after surgery. Baseline information on these patients was recorded and statistically analysed after our review.

Official Title
-----------------
A Retrospective Study of Factors Associated With Postoperative Recurrence of Incisional Hernia Repair in the Abdominal Wall

Conditions
-----------------
Incisional Hernia, Recurrent Hernia

Intervention / Treatment
-----------------
* Behavioral: Recurrence after surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Inclusion criteria: diagnosis of incisional hernia of the abdominal wall and primary; surgical treatment for hernia repair at our hospital; all patients originating from outpatient clinics rather than emergency clinics; age of 18 to 80 years at the time of admission; and those with a well-established preoperative examination. Exclusion Criteria: Exclusion criteria: severe organ dysfunction (ASA score of IV, V, VI); unconsciousness and poor cooperation with various preoperative examinations; correction of other types of abdominal hernia by perfect examination after admission; incomplete necessary information.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| The primary group<br> | |
| The recurrent group<br> | Behavioral: Recurrence after surgery<br>* Recurrence after repair was the main outcome<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrent | Recurrence after surgery repair | 2017.1-2023.8 |
Sonu Nasal Congestion Relief Study in Patients Suffering From Moderate to Severe Nasal Congestion

Study Overview
=================
Brief Summary
-----------------
To demonstrate the safety and effectiveness of Sonu for the treatment of patients suffering from moderate to severe nasal congestion.

Detailed Description
-----------------
Sonu consists of and acoustic vibrational headband worn circumferentially at the level of the forehead. A smart phone App, paired to the headband, delivers acoustic resonant frequencies of the subject's nasal cavity through the headband and provides relief. Sonu is intended to be used for the treatment of moderate to severe nasal congestion due to rhinitis.

Official Title
-----------------
Sonu Nasal COngestion RElief Study (SCORE)

Conditions
-----------------
Nasal Congestion and Inflammations

Intervention / Treatment
-----------------
* Device: Sonu


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years of age and older Present with symptoms of nasal congestion for 1 month or more prior to treatment Have a 24 hour reflective nasal congestion subscore of the TNSS of 2 or more on a 0 to 3 scale at the time of screening Exclusion Criteria: Head, nasal or sinus surgery within 3 months Sinus infection diagnosed within the last month, or rhinitis medicamentosa Documented history of nasal polyposis or mass

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sonu Treatment Group<br>Patients will receive acoustic resonance therapy for 15 minutes, twice a day, for two weeks using Sonu. | Device: Sonu<br>* Acoustic energy delivery<br>|
| Sham Comparator: Sham Control Group<br>Patients will receive non-resonant acoustic energy for 15 minutes, twice a day, for two weeks using Sonu. | Device: Sonu<br>* Acoustic energy delivery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Primary Effectiveness | Statistically significant improvement in nasal congestion subscore compared to baseline congestion score | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Secondary Effectiveness | Statistically significant improvement in total nasal symptom score (TNSS) compared to baseline TNSS | 2 weeks |