Exercise-snacks at Work: Impact on Cardiometabolic Parameters

Study Overview
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Brief Summary
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The main objective is to measure the effects of intense brief exercise program in the workplace of administrative staff on the cardio-metabolic health

Detailed Description
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Backgrounds: Very short (< 1 minute) and intense exercises, entitled exercise-snacks, have been reported to be effective 1) in improving physical fitness over 6 weeks and 2) in improving vascular function and lowering blood glucose levels over one day. These studies were all carried out in the laboratory. The question therefore arises as to whether these acute vascular and metabolic benefits, as well as those on physical fitness, are sustainable over time following a chronic exercise-snacks program applicable in the professional environment to sedentary, overweight people. Aims of this project is therefore to measure the effects of an exercise-snacks type physical activity program in the workplace of administrative staff on the cardio-metabolic health and sedentary behaviour of staff.

Official Title
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Exercise-snacks: an Effective Strategy to Break Sitting Time and Improve Cardiometbaolic Health in Sedentary Overweight Office Workers

Conditions
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Sedentary Time, Overweight and Obesity, Work-Related Condition

Intervention / Treatment
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* Other: Exercise-snacks program


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: administrative staff, age between 30 and 60, body mass index ≥25kg/m², sedentary time ≥7h/day, minimum 3 working days on site, no known cardiovascular or metabolic pathology, social security affiliation or benefit, ability and willingness to give free, written and informed consent. Exclusion Criteria: pregnant or breast-feeding women, anti-hypertensive treatment, beta-blockers and anti-diabetics, known contraindications to physical activity (articular, cardiac or other), exercise-induced asthma, lack of motivation of subjects posing problems of compliance and adherence to the exercise program, participation in a study in the preceding 3 months, ongoing participation in a clinical trial.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise-snacks group<br>They will perform a exercise-snacks program and receive information about physical activity | Other: Exercise-snacks program<br>* Subjects in the exercise-snacks group will perform 4 exercise-snacks sessions per working day for 4 weeks. These sessions will consist of 80 one-to-one walks to be completed as quickly as possible. They will also receive information about their attitudes to physical activity.<br>|
| No Intervention: Control group<br>They will maintain their usual lifestyle until the end of the study | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in aerobic fitness | Aerobic fitness will be assessed via the Chester step test's prediction of VO2max | at inclusion, at the end of the 4-weeks program and 1 month following the end of the program | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adherence of staff in the experimental group by analyzing accelerometric data. | Total number of exercise-snacks performed during the 4-week program by analysing accelerometers data | during the 4-weeks program | 
| Intensity of exercise-snacks | Heart rate during exercise-snacks in % heart rate max | during the 4-weeks program | 
| Changes in flow mediated dilation of superficial femoral artery | measured by echocardiography (Vivid Q, GE) , in % | at inclusion, at the end of the 4-weeks program | 
| Changes in peak shear rate of superficial femoral artery | measured by echocardiography (Vivid Q, GE) during hyperemia, in s-1 | at inclusion, at the end of the 4-weeks program | 
| Changes in nitrate mediated dilation of superficial femoral artery | by echocardiography (Vivid Q, GE), in % | at inclusion, at the end of the 4-weeks program | 
| Changes in superficial femoral artery compliance | by echocardiography (Vivid Q, GE), in mm2 mmHg-1 | at inclusion, at the end of the 4-weeks program | 
| Changes in carotid intima-thickness | by echocardiography (Vivid Q) in mm | at inclusion, at the end of the 4-weeks program | 
| Changes in carotid compliance | by echocardiography (Vivid Q) in mm2 mmHg-1 | at inclusion, at the end of the 4-weeks program | 
| Changes in carotid-femoral pulse wave velocity | by Sphygmocor, in m.s-1 | at inclusion, at the end of the 4-weeks program | 
| Changes in post-occlusive skin perfusion | by Laser Doppler (Perimed), in perfusion unit, in area under the curve, in time to peak | at inclusion, at the end of the 4-weeks program | 
| Changes in blood pressure | systolic, diastolic, mean and pulsed | at inclusion, at the end of the 4-weeks program and 1 month following the end of the program | 
| Changes in mean amplitude of glycemic excursions | measured by continuous glucose monitoring (FreeStyle), in mmol.L-1 | one week before the beginning of the program and the first week of the program and the 2 lastest weeks of the program | 
| Changes in heart rate | Heart rate at rest, at the end of the Chester step test and during exercise | between the beginning and end of the 4-week exercise program and 4 weeks after the program. | 
| Changes in level of habitual physical activity | Physical Activity questionnaire | between the start and end of the 4-week exercise program and 4 weeks after the program | 
| Changes in fat mass | measured by InBody, in kg | between the start and end of the 4-week exercise program and 4 weeks after the program | 
| Changes in lean mass | measured by InBody, in kg | between the start and end of the 4-week exercise program and 4 weeks after the program | 
| Change in physical activity behaviour at work of staff | Theory of planned behavior questionnaire, score range from 20 to 80 with higher scores mean a better outcome. | between the start and end of the 4-week exercise program. | 
| Changes in rating of perceived exertion | measured during the Chester test, score range from 7 to 20 with higher scores mean a worse outcome. | between the start and end of the 4-week exercise program and 4 weeks after the program | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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brief intense exercise, vascular function, cardiorespiratory fitness