Study of Biomarkers of Heat Tolerance and Recovery During Ultra-endurance Exercise

Study Overview
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Brief Summary
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Military personnel are called upon to serve in hot, dry or humid climates, which places great demands on their ability to tolerate heat. Induced heat stress can impair performance and lead to pathologies. Faced with the challenges of global warming, this issue is becoming increasingly important in the practice of sport. While hyperthermia is known to impair endurance performance, the underlying thermophysiological responses and regulatory mechanisms during prolonged exercise remain poorly understood. The effects of hyperthermia on mental performance raise questions about the degradation of interoceptive capacities and the deleterious impact on behavioral regulation, an important component of thermal risk management in ultra-endurance exercise. What's more, despite the muscular and hydromineral consequences (rhabdomyolysis, renal failure, dehydration) of prolonged exercise, few data are available on recovery kinetics. A better understanding of the factors conditioning recovery quality could help limit the deleterious consequences of ultra-endurance exercise.

Official Title
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Study of Biomarkers of Heat Tolerance and Recovery During Ultra-endurance Exercise

Conditions
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Heat Stress, Heat

Intervention / Treatment
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* Other: Passive heat exposure
* Other: Active heat exposure


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy individuals BMI between 18 and 25 kg/m2 Weight ≥ 51 kg Minimum training volume 6 days/7, aerobic Participation in a running competition ≥ 6hours Having given informed consent Exclusion Criteria: Presence or history of medical pathology Presence of significant deviation from normal electrocardiogram values History of heat stroke Known intolerance to heat Inability to swallow a capsule or refusal of rectal probe Alcohol consumption exceeding the equivalent of 3 glasses of wine per week Consumption of narcotics Smoking > 0.5 pack of cigarettes per day On usual medication Pregnant or breast-feeding women Protected adult, under legal protection, guardianship or curatorship, or unable to give personal written consent

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 37 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Passive heat exposure|Participants will be exposed to heat in a chamber.|
|Other: Active heat exposure|Participants will participate to a 6-hour run.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Degree of correlation between core temperature measured at the end of passive heat exposure and that measured at the end of active heat exposure | Core temperature will be measured in every participants at the end of passive heat exposure and at the end of active heat exposure. A correlation analysis will be performed on these measurements. | Through study completion (1 month) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ultra-endurance