Effects of Multimodal Physical Therapy in Patients With Lumbosacral Radiculopathy

Study Overview
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Brief Summary
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Purposes of the study To investigate the effect of Multimodal Physical Therapy on pain, daiablility H-reflex, and Diffusion Tensor Imaging (DTI) Parameters in Patients With Lumbosacral Radiculopathy.

Detailed Description
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Participants will receive Multimodal Physical Therapy program consisting of electrophysical agents, manual therapy interventions, and core stability exercises. Patients will receive the intervention for six weeks. Outcomes will be assessed at baseline and post-intervention.

Official Title
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Effects of Multimodal Physical Therapy on Pain, Disability, H-reflex, and Diffusion Tensor Imaging Parameters in Patients With Lumbosacral Radiculopathy

Conditions
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Lumbosacral Radiculopathy

Intervention / Treatment
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* Other: Multimodal Physical Therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: chronic (≥ 3 months) unilateral Lumbosacral Radiculopathy (LSR) The LSR is due to paracentral L4-L5 or L5-S1 Lumbar disc herniation The LSR is confirmed radiologically by MRI The LSR is confirmed clinically by history and physical examination The LSR is confirmed neurophysiological by soleus H-reflex assessment Body mass Index less than 30 20-45 years of age Exclusion Criteria: systematic disease Bilateral symptoms Lumbar spinal stenosis previous surgery Steroid injection Spinal fracture Lumbar spinal stenosis Spinal deformity Spinal fracture Radiological evidence of bilateral nerve root encroachmen Evidence of H-reflex amplitude or latency affection on asymptomatic side

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Multimodal Physical Therapy<br>Patients in this group will receive Multimodal Physical Therapy program consisting of electrophysical agents, manual therapy interventions, and core stability exercises. | Other: Multimodal Physical Therapy<br>* Multimodal Physical Therapy program consisting of electrophysical agents, manual therapy interventions, and core stability exercises<br>* Other names: Physiotherapy;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain | Visual analog scale (VAS) | Change from Baseline pain at 6 weaks | 
| Disability | Roland-Morris Disability Questionnaire (RMDQ) | Change from Baseline Disability at 6 weaks | 
| Soleus H-reflex amplitude | by EMG unit | Change from Baseline Soleus H-reflex amplitude at 6 weaks | 
| Soleus H-reflex side-to-side amplitude (H/H) ratio | by EMG unit | Change from Baseline Soleus H/H ratio at 6 weaks | 
| Fractional anisotropy (FA) of the compressed nerve root | by MRI examination | Change from Baseline Fractional anisotropy (FA) ratio at 6 weaks | 
| Apparent diffusion coefficient (ADC) of the compressed nerve root | by MRI examination | Change from Baseline Apparent diffusion coefficient (ADC) at 6 weaks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lumbosacral Radiculopathy, Lumbar disc herniation