linjc16/ctgov huggingface dataset:
Evaluation of Cryotherapy in Granuloma Pyogenicum

Study Overview
=================
Brief Summary
-----------------
Surgical excision needs general anesthesia and might have complications due to anesthesia. Cryotherapy can be used in an outpatient setting and doesn't need general anesthesia. This study will evaluate if cryotherapy works in granuloma pyogenicum with the advancement of no general anesthesia.

Official Title
-----------------
Evaluation of Cryotherapy in Granuloma Pyogenicum by Means of Cryopen Compared to Surgical Removal

Conditions
-----------------
Granuloma, Pyogenic, Cryotherapy Effect

Intervention / Treatment
-----------------
* Device: Cryopen - Cryotherapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diagnosis of granuloma pyogenicum Exclusion Criteria: no approvement of cryotherapy

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Cryotherapy<br>Cryotherapy on granuloma pyogenicum | Device: Cryopen - Cryotherapy<br>* Cryotherapy with N20<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrence of Granuloma pyogenicum |  | 1 year |
Bilateral Monofocal Versus Monofocal-EDOF IOL Implantation: Quality of Vision Comparison

Study Overview
=================
Brief Summary
-----------------
The goal of this clinical trial is to compare visual quality after cataract surgery between two groups: bilateral monofocal intraocular lenses (IOL) and monofocal and contralateral extended depth-of-focus (EDOF) IOL implantation. The main question it aims to answer is: • does the combination of both monofocal and EDOF IOLs presents an advantage over bilateral monofocal IOL implantation in the daily life of patients undergoing cataract surgery without the disadvantages of bilateral EDOF IOL implantation? Participants will: be randomised in either bilateral monofocal group or monofocal and EDOF group undergo visual acuity testing with and without correction at all distances be asked to complete a quality of vision questionnaire undergo non-invasive examinations to measure residual astigmatism, contrast sensitivity, straylight, optical aberrations, reading spead.

Official Title
-----------------
Combining a Monofocal With an EDOF IOL: Is There an Improvement in Quality of Vision After Cataract Surgery Over Bilateral Monofocal IOL Implantation.

Conditions
-----------------
Cataract

Intervention / Treatment
-----------------
* Device: cataract surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients aged between 50 and 90 years with bilateral cataract without concomitant exclusion criteria Exclusion Criteria: prior refractive surgery patients with corneal opacities, retinopathy, opticopathy, glaucoma, uveitis and amblyopia patients with corneal astigmatism greater than 3 diopters (D) patients with expected postoperative astigmatism higher than 0.50D prior ocular surgery in the last six months patients with prior unilateral cataract surgery

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Bilateral monofocal intraocular lens<br>Standard treatment | Device: cataract surgery<br>* cataract surgery<br>|
| Experimental: Monofocal and contralateral extended depth-of-focus intraocular lens<br>Experimental treatment | Device: cataract surgery<br>* cataract surgery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in binocular photopic distance corrected intermediate visual acuity between both groups using Radner chart. | Difference in binocular photopic distance corrected intermediate visual acuity between both groups using Radner chart. | 3 months |
Evaluation of Prevalence of Sexuality Alteration in Women With an Abnormal Pap Test

Study Overview
=================
Brief Summary
-----------------
Human Papilloma virus is the most common sexual infection in women, which can leads to cervical lesion and cervical cancer. Pap test is recommanded in women of 25 years old until 65 years old in order to screen subclinic lesions and improve prognosis. Yet, scientific knowledge about chronic disease showed negative consequences on quality of life. However, no study until now has striven to evaluate the consequences of an abnormal pap test on sexuality in adult women. The aim of this study is to evaluate if an abnormal pap test have an impact on the sexual functions in women because of the anxiety and psychological consequences of the diagnosis

Official Title
-----------------
Evaluation of Prevalence of Sexuality Alteration in Women With an Abnormal Pap Test

Conditions
-----------------
Sexual Dysfunction, Epidemiology

Intervention / Treatment
-----------------
* Other: questionnary


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult women with an abnormal pap test. Diagnosis known 4 to 12 weeks before the appointment for colposcopy Exclusion Criteria: Cervical cancer Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Adult women with an abnormal pap test<br> | Other: questionnary<br>* If agreeing to the protocol, ; patients will answered questions about sexual health during the gynecologic consultation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| % ofpositive response rate at the first question of the questionnaire |  | 18 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of causes of woman alteration sexual function alteration |  | 18 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Abnormal pap test, Sexual Dysfunction, Epidemiology
Tracheal, Lung, and Diaphragmatic Ultrasonography Applications for Rapid Confirmation of Endotracheal Tube Position

Study Overview
=================
Brief Summary
-----------------
Nowadays endotracheal intubation is considered a fundamental management procedure during emergency resuscitation. Unrecognized misplacement of the ETT during endotracheal intubation and ventilation, has a reported incidence of 2.9-16.7% and is a frequent cause of morbidity and mortality in emergency intubations. The aim of this study is to determine the diagnostic accuracy of the tracheal, diaphragmatic and sonographic estimation of lung sliding for the rapid verification of endotracheal tube position in the intensive care unit (RICU) with reference to Co₂ monitors (capnography) (the gold standard technique)

Official Title
-----------------
Tracheal, Lung, and Diaphragmatic Ultrasonography Applications for Rapid Confirmation of Endotracheal Tube Position

Conditions
-----------------
Endotracheal Intubation

Intervention / Treatment
-----------------
* Device: Ultrasonography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age >18 years old with endotracheal intubation Having normal airway anatomy Exclusion Criteria: Age below 18 years old Neck deformities, Presence in history of neck radiation, Cervical spine immobility/instability Unstable vital signs Unwilling to participate or denial of informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Ultrasonography|Tracheal, diaphragmatic and lung ultrasonography|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The verification of endotracheal tube position using the ultrasonography in the respiratory intensive care unit (RICU) with reference to Co₂ monitors (capnography) (the gold standard technique) | The confirmation of endotracheal tube position using the tracheal, diaphragmatic and sonographic estimation of lung sliding for the rapid verification of endotracheal tube position in the intensive care unit (RICU) with reference to Co₂ monitors (capnography) (the gold standard technique) | one hour | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ETT
Prospective Coronary Heart Disease Cohort

Study Overview
=================
Brief Summary
-----------------
To evaluate the biomarkers for the prognosis of coronary heart disease, patients with coronary heart disease will be recruited and followed up for at least 2 years.

Detailed Description
-----------------
Patients with cardiovascular disease undergoing coronary angiography will be recruited and prospectively followed up for the incidence of major adverse cardiovascular events (MACE events), including all-cause mortality, cardiovascular mortality, ischemic stroke, heart failure and rehospitalization. Blood and fecal samples will be collected for further analysis. The basic and clinical information will be collected such as socio-demographic, diet, lifestyle, psychological status and medical history. The biomarkers for the incidence of coronary heart disease and the factors contributing to the poor prognosis of coronary heart disease will be investigated based on multi-omics analysis.

Official Title
-----------------
A Prospective Longitudinal Multi-Omics Cohort of Patients With Coronary Heart Disease Undergoing Coronary Angiography

Conditions
-----------------
Coronary Heart Disease, Myocardial Infarction

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosed as coronary heart disease or with unexplained chest pain needed to undergo coronary angiography. Healthy subjects undergoing routine physical examination in the physical examination department and willing to sign informed consent will be recruited as control subjects. Exclusion Criteria: With malignant tumors, infectious diseases and advanced liver diseases. Won't sign an inform consent.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| major adverse cardiovascular events | all-cause mortality, cardiovascular mortality, ischemic stroke, heart failure and rehospitalization | 2-year outcome and long-term outcome |
QIAstat-Dx® Respiratory Panel Plus (RPP) Clinical Performance Study

Study Overview
=================
Brief Summary
-----------------
This study will evaluate the clinical performance of the QIAstat-Dx® Respiratory Panel Plus (RPP) SARS-CoV-2 target with a validated comparator method

Detailed Description
-----------------
This multicentre study aims to evaluation the clinical performance of the QIAstat-Dx® Respiratory Panel Plus (RPP) SARS-CoV-2 target with a validated comparator method

Official Title
-----------------
An Observational Prospective Clinical Study to Assess Clinical Performance of QIAstat-Dx® Respiratory Panel Plus (RPP) SARS-CoV-2 Target in the Intended Use Population and Environment

Conditions
-----------------
Respiratory Disease

Intervention / Treatment
-----------------
* Device: QIAstat-Dx® Respiratory Panel Plus (RPP)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Presenting with signs and symptoms of a respiratory infection. Consent or assent to be obtained Able to communicate (speak, read and write) in local language, and able to understand and sign the required study documents. Willing and able to provide Nasopharyngeal Swab (NPS) Specimen collected per manufacturer's instructions. Exclusion Criteria: Subjects who, in the opinion of the Investigator, are unsuitable for participation in the study.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: QIAstat-Dx® Respiratory Panel Plus (RPP)|An observational prospective performance evaluation study of QIAstat-Dx® Respiratory Panel Plus (RPP) SARS-CoV-2 target against a marketed comparator, using NPS collected per the manufacturer's instructions and eluted in Universal Transport Media (UTM) from subjects with signs and symptoms of respiratory infection|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PPA | positive percentage agreement | 8 weeks | 
| NPA | negative percentage agreement | 8 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Respiratory Virus, SARS-CoV-2 coronavirus
In-Office Clinical Study of the Solo+ TTD

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to evaluate the safety and effectiveness of the Solo+ Tympanostomy Tube Device (Solo+ TTD) for the placement of tympanostomy tubes in paediatric patients undergoing a tympanostomy procedure.

Detailed Description
-----------------
The study will be a multi-site, prospective, treatment-only study to gather safety and effectiveness data on the use of the Solo+ TTD in-office with topical anesthesia in children aged ≥6 months to <13 years.

Official Title
-----------------
Pivotal In-Office Clinical Study of the Solo+ Tympanostomy Tube Device

Conditions
-----------------
Ear Infection, Otitis Media

Intervention / Treatment
-----------------
* Device: Solo+ Tympanostomy Tube Device (Solo+ TTD)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients aged ≥6 months to <13 years Planned tympanostomy tube insertion Patient is able to commit to the follow-up visits and assessments Exclusion Criteria: Anatomy that precludes sufficient visualization of the tympanic membrane Anatomy that precludes safe access to the tympanic membrane and safe use of the Solo+ TTD Narrow ear canals Congenital or craniofacial abnormalities affecting the ear No baseline audiometry or tympanometry Familial history of insensitivity to anesthetic components Patient unable to remain still or is unsuitable for protective stabilization to undergo an in-office procedure

Ages Eligible for Study
-----------------
Minimum Age: 6 Months
Maximum Age: 13 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Solo+ Tympanostomy Tube Device (Solo+ TTD)<br>The Solo+ TTD is a disposable surgical tool designed to deliver a tympanostomy tube into the tympanic membrane of patients undergoing a tympanostomy tube placement procedure. | Device: Solo+ Tympanostomy Tube Device (Solo+ TTD)<br>* The Solo+ TTD is intended to deliver a tympanostomy tube through the tympanic membrane of a patient.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Procedure Success | Percentage of subjects in which the Solo+ TTD tympanostomy tube is inserted in all indicated ears | Intra-operative | 
| Rate of Adverse Events | Incidence and nature of device- or procedure-related adverse events | 24 months |
Evaluation of 3D Michigan Appliance

Study Overview
=================
Brief Summary
-----------------
20 patients will be divided into 2 groups Group 1 : in which conventional appliance will be constructed after alginate impression Group 2 : in which 3d printed appliance will be constructed after intra-oral scanning

Official Title
-----------------
Development of Algorithm for 3d Printed Michigan Appliances in Patients With Temporomandibular Disorders

Conditions
-----------------
Myofacial Pain Syndromes

Intervention / Treatment
-----------------
* Device: 3D printed mitchigen appliance
* Device: side chair appliance


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient with bruxism Trigger points Medically stable Exclusion Criteria: • absence of other TMJ problem

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 3d printed appliance<br> | Device: 3D printed mitchigen appliance<br>* the process of appliance construction done by intra-oral scanning of the arch and 3d printing<br>|
| Active Comparator: side chair appliance<br> | Device: side chair appliance<br>* the impresion will be taken to make a cast to reconstruct the appliance<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| visual analogue scale | pain assessment by visual analogue scale immediate postoperative and 6 months later | Change from immediate postoperative to 6 months |
Salivary Expression of SOX7 in Oral Squamous Cell Carcinoma: Diagnostic Accuracy Study

Study Overview
=================
Brief Summary
-----------------
The study will include patients with oral cancer and healthy controls of both sexes. Subjects having any systemic diseases or other types of cancer will be excluded. All subjects will be selected from Oral Medicine Department, Faculty of Dentistry, Al Ahram Canadian University and Fayoum University. Informed consent will be obtained from all subjects enrolled in this study after explanation of the whole procedure.

Official Title
-----------------
Salivary Expression of SOX7 in Oral Squamous Cell Carcinoma: Diagnostic Accuracy Study

Conditions
-----------------
Oral Cancer, Oral Squamous Cell Carcinoma

Intervention / Treatment
-----------------
* Diagnostic Test: ELISA


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with oral cancer Exclusion Criteria: any systemic diseases or other types of cancer will be excluded

Ages Eligible for Study
-----------------
Minimum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Oral Cancer Group<br>23 patients with oral cancer | Diagnostic Test: ELISA<br>* quantitative determination of salivary SOX7 using an Enzyme Linked Immunosorbent assay (ELISA) kit based on the sandwich principle according to the manufacturer's protocol.<br>|
| Control Group<br>23 age-and-sex-matched healthy individuals, as normal controls | Diagnostic Test: ELISA<br>* quantitative determination of salivary SOX7 using an Enzyme Linked Immunosorbent assay (ELISA) kit based on the sandwich principle according to the manufacturer's protocol.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| salivary expression of SOX7 |  | 2 months |