The South Texas Aging Registry and Repository

Study Overview
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Brief Summary
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This research registry and repository was designed because the investigators want to learn about how to improve the health and quality of life of older adults.

Detailed Description
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The South Texas Aging Registry and Repository (STARR) is a database and specimen resource of community dwelling adults from the South Texas area who are interested in volunteering for research studies on aging. The goal is to assist in the inclusion of older adults in clinical research studies and to help to increase the quantity and quality of research relating to them. This registry and repository can be used for various purposes ranging from describing the natural history of aging, identifying risk factors for premature aging, and the real-world effectiveness of life-extending therapies. Collection and storage of biological samples and patient-reported data from of Individuals can help advance research and the development of new awareness of basic mechanisms that play a part in healthy aging or premature death.

Official Title
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The South Texas Aging Registry and Repository (STARR)

Conditions
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Aging

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria STARR: -Age 18 years or older Inclusion Criteria KAPP Sen TMC: -Age 20 years and older Exclusion Criteria STARR: Inability to provide informed consent Pregnancy Exclusion Criteria KAPP Sen Tissue Mapping Center (TMC) Study: Diabetes Hypertension with end-organ damage BMI>30 GFR<60 ml/min/1.73 m2 Cardiovascular disease Pancreatitis Malignancy other than non-melanoma skin cancers Active, uncontrolled pulmonary, hepatic, infectious, gastrointestinal, endocrine, neurologic, or inflammatory disease. Chronic use of systemic steroids or use of agents with senolytic activity Any disease or condition considered to be exclusionary based on the clinical option and discretion of PI

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Primary Study<br>Community dwelling adults from the South Texas area who are interested in volunteering for research studies on aging. This will facilitate the inclusion of older adults and minority in research studies and help to increase the quantity and quality of research relating to them. | |
| KAPP Sen Tissue Mapping Study<br>The substudy KAPP Sen TMC will enroll eligible STARR participants to undergo repeat assessments over two years. KAPP Sen TMC is a collaborative effort between UT Health San Antonio, Jackson Laboratory for Genomic Medicine (JAX-GM), Brigham and Women's Hospital, Joslin Diabetes Center, UConn Health Center on Aging and Mayo Clinic to characterize cellular senescence in terms of its presence and heterogeneity in healthy human tissues, as well as its tissue burden, spatial distribution, and biological features in a diverse study population. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Collection of STARR repository data | De-identified repository data and samples will be made available to outside investigators for future studies related to aging | Baseline to one day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| KAPP Sen TMC repository data | Eligible STARR participants to undergo repeat assessments to characterize cellular senescence | Baseline to one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Older adults, Genetic material, Biorepository