Optimal PEEP in Pediatric Patients Under 17 Years of Age.

Study Overview
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Brief Summary
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This study aimed to investigate the differences in positive end-expiratory pressure titration in the supine and prone positions by age in pediatric patients under 17 years of age who received general anesthesia and then evaluate the hemodynamic stability.

Official Title
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Determination of Optimal Positive End-expiratory Pressure in Prone Position During General Anesthesia Using Electrical Impedance Tomography in Pediatric Patient Under 17 Years of Age

Conditions
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Ventilation Therapy; Complications

Intervention / Treatment
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* Other: ventilation strategy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients who are scheduled to undergo general anesthesia in the prone position patients who are in age under 17 years Exclusion Criteria: had cyanosis or chronic respiratory failure had respiratory distress syndrome or bronchopulmonary dysplasia had laryngotracheal diseases had pulmonary hypertension receiving oxygen therapy

Ages Eligible for Study
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Minimum Age: 0 Years
Maximum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Experimental arm<br>All patients will be enrolled in the same arm. | Other: ventilation strategy<br>* Titrating positive end-expiratory pressure<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Optimal positive end-expiratory pressure (PEEP) | result of decremental PEEP trial | 10 minutes after intubation | 
| Optimal positive end-expiratory pressure (PEEP) | result of decremental PEEP trial | 60 minutes after prone positioning | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Impedance tidal variation | respiratory parameters measured by Electrical Impedance Tomography (EIT) device | 10 minutes after intubation | 
| Impedance tidal variation | respiratory parameters measured by EIT device | 60 minutes after prone positioning | 
| regional respiratory system compliance | respiratory parameters measured by EIT device | 60 minutes after prone positioning | 
| regional respiratory system compliance | respiratory parameters measured by EIT device | 10 minutes after intubation | 
| overdistension or atelectasis | respiratory parameters measured by EIT device | 10 minutes after intubation | 
| overdistension or atelectasis | respiratory parameters measured by EIT device | 60 minutes after prone positioning | 
| end-expiratory lung volume | respiratory parameters measured by EIT device | 10 minutes after intubation | 
| end-expiratory lung volume | respiratory parameters measured by EIT device | 60 minutes after prone positioning | 
| end-expiratory lung impedance | respiratory parameters measured by EIT device | 10 minutes after intubation | 
| end-expiratory lung impedance | respiratory parameters measured by EIT device | 60 minutes after prone positioning | 
| regional ventilation delay | respiratory parameters measured by EIT device | 10 minutes after intubation | 
| regional ventilation delay | respiratory parameters measured by EIT device | 60 minutes after prone positioning | 
| center of ventilation | respiratory parameters measured by EIT device | 10 minutes after intubation | 
| center of ventilation | respiratory parameters measured by EIT device | 60 minutes after prone positioning | 
| vital signs | blood pressure (mmHg) | 10 minutes after intubation | 
| vital signs | blood pressure (mmHg) | 60 minutes after prone positioning | 
| vital signs | oxygen saturation (%) | 10 minutes after intubation | 
| vital signs | oxygen saturation (%) | 60 minutes after prone positioning | 
| vital signs | heart rate (BPM) | 10 minutes after intubation | 
| vital signs | heart rate (BPM) | 60 minutes after prone positioning | 
| arterial blood gas analysis, if patients has arterial catheter | oxygen and cardon dioxide tension | 10 minutes after intubation & 60 minutes after prone positioning |