linjc16/ctgov huggingface dataset:
Aberrant Myeloid Lineage Differentiation in HIV/AIDS Patients

Study Overview
=================
Brief Summary
-----------------
The investigators included 782 HIV-infected patients from January 2016 to October 2020 Zhongnan Hospital of Wuhan University, whose AIDS diagnosis criteria met the AIDS Diagnosis and Treatment Guide (2018 edition) of Chinese Medical Association.

Official Title
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A Single-center, Retrospective Cohort Study of Aberrant Myeloid Lineage Differentiation in HIV/AIDS Patients

Conditions
-----------------
HIV Infections, Leukemia

Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: HIV-infection Exclusion Criteria: -
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| HIV without leukemia<br> | |
| HIV leukemia<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The proportion of granulocytes and granulocyte/macrophage progenitors in myelogram of HIV/AIDS patients | Flow cytometric immunophenotyping of an EDTA-anticoagulated BM aspirate specimen was performed. A standard BM assay with erythrocyte cell lysis was used for all BM aspirate specimens. Flow cytometric analysis was conducted using a FACS Canto II flow cytometer (Becton Dickinson, Sunnyvale, CA, USA). | 2020 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neutrophil counts in peripheral blood of HIV/AIDS patients | Blood samples were drawn from patients undergoing routine diagnostic blood analysis at our institute by sterile venipuncture into tubes containing 5.4 mg of K2EDTA and analyzed by the automated hematology analyzer. | 2020 |
Insights Into Participating in Studies for Uterine Cancer

Study Overview
=================
Brief Summary
-----------------
Clinical study participation has historically been heavily biased toward specific demographics. Several people will be invited to enroll in this trial so that it may collect a variety of data about uterine cancer clinical study experiences and identify barriers to participation as well as the causes of participants' failure or withdrawal. People with uterine cancer who are invited to take part in medical study will benefit from the analysis of the data.

Official Title
-----------------
Exploring Uterine Cancer Clinical Trials - Revealing Participation Patterns in Individuals With Uterine Cancer

Conditions
-----------------
Uterine Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Aged ≥ 18 years old and ability to provide written informed consent obtained prior to participation in the study and any related procedures being performed Diagnosis of uterine cancer No prior treatment for uterine cancer Exclusion Criteria: Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial Enrolled in another research study Inability to provide written informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients who decide to enroll in a uterine cancer clinical research |  | 3 months | 
| Rate of patients who remain in a uterine cancer clinical trial to trial completion |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Uterine Cancer
Adjust-Unlikely PE

Study Overview
=================
Brief Summary
-----------------
The aim of this pilot study is to assess the feasibility of a larger study to determine the Adjust-Unlikely algorithm safety and efficiency for diagnosing PE. The pilot study objectives are to: Determine study recruitment rate, per site, per month Determine study 90-day loss to follow up rate Estimate of the proportion of enrolled patients who test negative for PE at initial assessment using the Adjust-Unlikely rule Estimate of the Adjust-Unlikely algorithm efficiency Compare excluded and missed-eligible patients to study participants: age, sex and prevalence of PE diagnoses at initial testing. The pilot study hypothesis is that the investigators can recruit at least 20 patients per month and successfully follow at least 90% of patients for 90 days.

Official Title
-----------------
A Pilot Study to Assess Feasibility of Evaluating the Safety and Efficiency of a Simplified Diagnostic Approach for Pulmonary Embolism

Conditions
-----------------
Pulmonary Embolism (Diagnosis)

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Emergency physician decides to test for PE Exclusion Criteria: Tested for PE without using the Adjust-Unlikely algorithm D-dimer level is known before Adjust-Unlikely assessment A new indication for anticoagulation on emergency department assessment (other than pulmonary embolism) in a patient not previously prescribed an anticoagulant Declines participation Is inaccessible for follow-up Has previously participated in this study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The proportion of patients who have PE excluded by the Adjust-Unlikely algorithm and who are subsequently diagnosed with either PE or lower limb DVT. |  | 90 days following index presentation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
emergency medicine, standardization of practice, diagnostics evaluation
Temporomandibular Dysfunction in Patients With Cervical Disc Herniation

Study Overview
=================
Brief Summary
-----------------
Cervical spine problems are associated with temporomandibular joint (TMJ) and related muscles.The aim of the present study was to investigate temporomandibular joint dysfunction (TMD) and pain in individuals with cervical disc herniation (CDH) according to the level of neck disability.

Detailed Description
-----------------
The study included diagnosed with cervical disc herniation. The participants were divided into two groups based on their The Neck Disability Index (NDI) score: Group 1 with no disability and mild disability and Group 2 with moderate and severe disability. Temporomandibular dysfunction and its severity, intensity of neck and temporomandibular joint pain was assessed.

Official Title
-----------------
Investigation of Temporomandibular Dysfunction in Patients With Cervical Disc Herniation

Conditions
-----------------
Temporomandibular Joint Dysfunction Syndrome

Intervention / Treatment
-----------------
* Other: questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosed with cervical disc herniation aged between 18 and 65, who could read and write in Turkish Exclusion Criteria: Individuals with a history of head and neck surgery, fracture, physiotherapy or medical treatment cervical or temporomandibular joint treatment within the last six months, presence of any inflammatory rheumatic diseases, such as ankylosing spondylitis and rheumatoid arthritis, facial paralysis, infection, advanced osteoporosis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1<br>no disability and mild disability | Other: questionnaire<br>* Neck Disability Index, The Fonseca Anamnestic Index (FAI) and Visual Analogue Scale (VAS)<br>|
| Group 2<br>moderate and severe disability | Other: questionnaire<br>* Neck Disability Index, The Fonseca Anamnestic Index (FAI) and Visual Analogue Scale (VAS)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neck Disability Index | Assessment of neck disability | one day assessment | 
| Fonseca Anamnestic Index | Assessment of temporomandibular dysfunction | one day assessment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual Analogue Scale | Assessment of temporomandibular joint pain and neck pain intensity | one day assessment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Temporomandibular Joint Dysfunction Syndrome, Intervertebral Disc Displacement, Disability, Neck, Jaw
Use of Laparoscopy in the Treatment of Pelvic Ring Ruptures

Study Overview
=================
Brief Summary
-----------------
Case series to describe the use of laparoscopy for the treatment of pelvic ring disruption.

Official Title
-----------------
Use of Laparoscopy in the Treatment of Pelvic Ring Ruptures

Conditions
-----------------
Pelvic Fracture

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients who underwent laparoscopy for the treatment of pelvic ring disruption Exclusion Criteria: patient < 18 years old

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| conversion rate to open surgery | conversion rate to open surgery | intraoperative | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pelvic ring surgery, Trauma Surgery, Plate Fixation, Laparoscopy, Case series
A Liquid Biopsy Diagnostic Techniques for Endometriosis

Study Overview
=================
Brief Summary
-----------------
To evaluate the diagnostic efficiency of circulating endometrial cell detection method using microfluidic chip as an non-invasive method for diagnosis in endometriosis.

Detailed Description
-----------------
Endometriosis is a chronic condition, characterized by the presence of functional endometrial glands and interstitium in extrauterine ectopia. Ectopic endometrial tissue responds to estradiol and other hormones similar to normal endometrium. Endometriosis is one of the most common benign gynaecological conditions, affecting up to 5 to 10 percent of women of reproductive age. In addition to severe dysmenorrhea or pelvic pain, decreased fertility is a common clinical manifestation of internal heterogeneity, with up to 40 percent of patients associated with infertility . Currently, laparoscopy is the gold standard for diagnosis. However, the actual time to diagnosis in patients with internal dysmorphia is delayed by an average of 4 to 11 years, resulting in a large number of patients with moderate to severe (stage III to IV) at diagnosis. Recently, the exploration of efficient and cost-effective non-invasive diagnostic solutions has been a hot button issue.

Official Title
-----------------
A Pilot Study of Liquid Biopsy Diagnostic Techniques for Endometriosis

Conditions
-----------------
Liquid Biopsy, Endometriosis

Intervention / Treatment
-----------------
* Diagnostic Test: Three-Dimensional Poly(dimethylsiloxane) Scaffold


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: • Surgically and pathologically verified patients with or without endometriosis Exclusion Criteria: suspicion of malignancy pregnancy acute infection Lack of ability to sign informed consent forms on their own

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Three-Dimensional Poly(dimethylsiloxane) Scaffold|The rest blood samples from patients with and without endometriosis (No. 20 VS 20) would be collected for testing on a Microchip Embedded with Three-Dimensional Poly(dimethylsiloxane) Scaffold.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of cases with identified circulating endometrial cells. | To evaluate the ability of the Three-Dimensional Poly(dimethylsiloxane) Scaffold to isolating circulating endometrial cells (CEC) in patients with and without endometriosis. In each group, the percentage of cases with identified circulating endometrial cells will be estimated. | within one week after blood sample collecting |
Optimizing Postoperative Pain Control After Laparoscopic Colorectal Surgery

Study Overview
=================
Brief Summary
-----------------
Erector spinae plane block (ESPB) is a novel regional block technique that was proven to have superior outcomes in relieving postoperative pain in colorectal surgeries.Ketamine enhances the impact of local anaesthetics by reducing the duration and extent of motor block while shortening the onset of sensory and motor block.Transdermal Fentanyl Patch (TFP) was better than transdermal buprenorphine in postoperative analgesia following abdominal surgeries.

Official Title
-----------------
Optimizing Postoperative Pain Control After Laparoscopic Colorectal Surgery by Supplementing Ultrasound-guided Erector Spinae Plane Block With Ketamine or Transdermal Fentanyl Patch

Conditions
-----------------
Postoperative Pain

Intervention / Treatment
-----------------
* Other: Bupivacaine and ketamine
* Other: Bupivacaine and transdermal fentanyl patch
* Other: Bupivacain


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients undergoing laparoscopic colorectal surgery. American Society of Anesthesiologists (ASA) physical status I or II. Exclusion Criteria: Known allergy to one of the study medications. Skin infections at the site of the needle puncture. Hepatic, renal or cardiac dysfunction. Patients diagnosed with obstructive sleep apnoea

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Bupivacaine and ketamine<br> | Other: Bupivacaine and ketamine<br>* Bilateral erector spinae plane block (bupivacaine and ketamine)<br>|
| Other: Bupivacaine and transdermal fentanyl patch<br> | Other: Bupivacaine and transdermal fentanyl patch<br>* Bilateral erector spinae plane block (bupivacaine) and transdermal fentanyl patch<br>|
| Other: Bupivacaine<br> | Other: Bupivacain<br>* Bilateral erector spinae plane block (bupivacaine)<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The total rescue analgesia consumption (mg) | The total rescue analgesia consumption (mg) in the first 48 hours after surgery | in the first 48 hours after surgery |
Harnessing Health IT to Promote Equitable Care for Patients With Limited English Proficiency and Complex Care Needs

Study Overview
=================
Brief Summary
-----------------
This is a pragmatic trial that will measure if the use of AI to identify patients with complex care needs and language barriers, as well as active reaching out to clinicians to offer the use of interpreter services will improve the frequency of interpreter use and reduce the time to first interpreter use

Official Title
-----------------
Harnessing Health Information Technology to Promote Equitable Care for Patients With Limited English Proficiency and Complex Care Needs

Conditions
-----------------
Limited English Proficiency, Artificial Intelligence, Machine Learning, Language Barrier, Complex Medical Needs

Intervention / Treatment
-----------------
* Other: Complexity score and implementation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults with limited English proficiency and requiring an interpreter and having complex medical care needs (includes admitted to the ICU, prolonged hospital stay, requiring palliative care) Have research authorization Exclusion Criteria: - Do not require an interpreter

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: This is a pragmatic clinical trial-a stepped wedge cluster randomized control trial
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br>This is the control group who receive standard of care | |
| Experimental: Intervention<br>This is the group in units who are identified via AI model and in which interpreter services are actively reaching out to clinicians | Other: Complexity score and implementation<br>* AI machine learning model to identify patients with complex care needs and implementation with active reaching out to clinicians to offer interpreter services<br>* Other names: AI machine learning model and implementation with reaching out to clinicians;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of interpreters | the number of interpreters used among patients with LEP and complex care needs | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in time to interpreter use | The time measured in hours and minutes for an interpreter to be used for patients with LEP | 12 months |
Genetic Test Based Risk Prediction of Early Calcific Aortic Valve Disease in Patients With Bicuspid Aortic Valve

Study Overview
=================
Brief Summary
-----------------
This study is to elucidate the impact of germline mutations and clonal hematopoiesis (CHIP) on the progression of early aortic valve calcification in patients with bicuspid aortic valves. The study will be conducted over a recruitment period of one year and a follow-up observation period of two years. Considering a 2-year event rate and a 33% occurrence rate of clonal hematopoiesis, each group requires a minimum of 102 participants. Accounting for a 15% dropout rate, a total of 120 participants are needed for each group (type I error (α) = 5%, type II error (β) = 20%). Therefore, the total study population, including patients with normal aortic valve function, is set at 240 participants.

Official Title
-----------------
Genetic Test Based Risk Prediction of Early Calcific Aortic Valve Disease in Patients With Bicuspid Aortic Valve

Conditions
-----------------
Bicuspid Aortic Valve

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with confirmed bicuspid aortic valves based on cardiac imaging (echocardiography, CT, MRI) or surgical findings. Early aortic valve calcification group: Patients aged 20-80 with moderate or greater aortic valve stenosis/regurgitation. Normal functioning aortic valve group: Patients aged 20-80 with mild or less aortic valve stenosis/regurgitation. Patients who understand the purpose of the study and voluntarily consent to participate. Exclusion Criteria: Patients with malignant neoplastic diseases or other conditions, such as cerebrovascular accidents, which predict survival of less than 6 months. Patients with unclear presence of bicuspid aortic valves. Patients with stage 3 or higher chronic kidney disease. Patients with other inherited cardiac conditions. Patients with cognitive impairment or hemodynamically unstable patients who have difficulty understanding the study content.

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of germline mutation |  | 2 years follow-up | 
| Clonal hematopoiesis of indeterminate potential (CHIP) mutation | Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally expanded hematopoietic stem cell caused by a leukemogenic mutation. | 2 years follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression of aortic valve calcification | Progression of aortic valve calcification measured by computed tomography (AV calcium score) or Echocardiography (Progression of AS/AR) | 2 years follow-up |