Thromboembolic Complications in COVID-19 Patients in Intensive Care Unit

Study Overview
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Brief Summary
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The present study aims to determine frequency of thromboembolic complications and the underlying causes of this complication of the patients who admitted to the intensive care unit diagnosed with COVID-19.

Detailed Description
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Patients diagnosed with COVID-19 infection and admitted to the ICU were recruited. Demographic information, comorbidities, length of ICU stay, some laboratory data,thromboembolic complications of the patients were recorded.

Official Title
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Incidence of Thromboembolism in COVID-19 Infection in the ICU: a Retrospective Cohort Analysis

Conditions
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COVID-19-Associated Thromboembolism

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who were infected with COVID-19 and admitted to the intensive care unit between the time of March 2020-December 2021 Exclusion Criteria: who is under 18 years old.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Ancestral variant<br>Ancestral variant is the first subtype of SARS CoV-2 virus which is the agent of first COVID-19 infection in Wuhan. Thromboembolic complications of this group were detected among patients which were infected with ancestral variant of COVID-19 | |
| Delta Variant<br>Delta variant is the subtype of SARS CoV-2 virus which is first COVID-19 subtype identified in India. Thromboembolic complications of this group were detected among patients which were infected with delta variant of COVID-19 | |
| Alpha variant<br>Alpha variant is the subtype of SARS CoV-2 virus which is first identified COVID-19 subtype in United Kingdom. Thromboembolic complications of this group were detected among patients which were infected with alpha variant of COVID-19 | |
| Other variants<br>Other variants is the subtype of SARS CoV-2 virus which were identified in Brazil, South Africa..etc. Thromboembolic complications of this group were detected among patients which were infected with alpha variant of COVID-19 | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of thromboembolic complications among patients who effected from different variants of COVID-19 Disease | Both arterial and venous thromboembolic events were detected | During the entire intensive care stay up to 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of thromboembolic complications of COVID-19 disease in critically ill patients | Both arterial and venous thromboembolic events were detected | During the entire intensive care stay up to 1 day | 
| Rate of thromboembolic complications according to anticoagulant therapy | Antithrombotic therapy of each patient was recorded | During the entire intensive care stay up to 1 day | 
| What is the rate of thromboembolism according to the comorbidities | Comorbidities of each patient were recorded from the patients records. | During the entire intensive care stay up to 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COVID-19, thromboembolism, Variants of COVID-19