Comparison of Co2 Laser Versus Co2 Laser With PRP in Scars

Study Overview
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Brief Summary
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Objective: To compare the effect of Fractional Carbon dioxide Laser (FCL) Vs Fractional Carbon dioxide Laser with platelet rich plasma (PRP) in management of Scars. Study design: Randomized-controlled trial (RCT). Study setting and duration: Dermatology Department, CMH-Abbottabad, November 2022/April 2023. Methodology: The sample size of 60 patients, age 18 to 50 years, was calculated by using Openepi app and the non-probability consecutive sampling technique was used. Patient in group A received FCL treatment's four sessions with four weeks apart, whereas Group B received four PRP and FCL sessions. The Quartile grading scale (score 0 is <25%, score 1 is 25-50%, score 2 is 51-75% and score 3 is >75% improvement) was used to assess the patient's clinical improvement at 4 weeks after each session. To determine statistical significance χ2-square test, taking p-value <0.05 as significant, was used.

Official Title
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Comparative Study on the Efficacy of Fractional CO2 and Fractional CO2 Laser With Autologous Platelet Rich Plasma in Scars

Conditions
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CO2 Laser in Scars

Intervention / Treatment
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* Procedure: Fractional CO2 laser
* Procedure: Fractional CO2 with Platelet Rich Plasma


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged 18-50 years Fitzpatrick skin type III-V Presented with post-acne, post traumatic or post burn scars all those patients emotionally balanced with realistic expectations were included in the study. Exclusion Criteria: scar that was less than 6 months old if they had an active infection or inflammatory skin condition having a history of malignancy a known connective tissue illness history of excessive bleeding or keloids unrealistic expectations pregnant or breastfeeding.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Fractional Co2 laser<br>Patient in group A received FCL treatment's four sessions four weeks apart. | Procedure: Fractional CO2 laser<br>* Patient in group A received FCL treatments four sessions with four weeks apart<br>|
| Active Comparator: Platelet Rich Plasma<br>Group B received fractional CO2 with four Platelet Rich Plasma sessions,4 weeks apart. | Procedure: Fractional CO2 with Platelet Rich Plasma<br>* Group B received four PRP and FCL sessions 4 weeks apart<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quartile grading scale for assessment of scars | Quartile grading scale was used to assess effectiveness of CO2 laser and CO2 laser with Platelet rich plasma in scars.Minimum score=0,Maximum Score=3 .Maximum score means better outcome.The Quartile grading scale (score 0 is <25%, score 1 is 25-50%, score 2 is 51-75% and score 3 is >75% improvement) was used to assess the patient's clinical improvement at 4 weeks after each session. | 16 weeks |