Retrospective Review of Esophageal Cancer at MSKCC

Study Overview
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Brief Summary
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Residual tumor at the proximal or distal margin after esophagectomy is a known prognostic factor for poor survival outcomes in patients with esophageal cancer; however, the significance of the circumferential resection margin (CRM) remains controversial. In this study, the investigators sought to evaluate the prognostic significance of the CRM in patients with esophageal cancer undergoing resection.

Official Title
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Retrospective Review of Esophageal Cancer at MSKCC

Conditions
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Esophageal Cancer, Esophagus Cancer

Intervention / Treatment
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* Procedure: Esophagectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Histologically confirmed esophageal adenocarcinoma (EAC) or esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy Pathologic staged T3 tumors (pT3) Exclusion Criteria: Pathologic staged T0-2 (pT0-2) or T4 tumors (pT4) Patients with histologic types other than EAC or ESCC, dysplasia or carcinoma in situ without tumor invasion, Patients undergoing salvage esophagectomy Evidence of distant metastatic disease Patients with a positive proximal or distal margin

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Circumferential resection margin (CRM)<br>Participants will have a diagnosis of esophageal carcinoma and residual tumor >1 mm from the CRM | Procedure: Esophagectomy<br>* Esophagectomy<br>|
| Circumferential resection margin (CRM)-close<br>Participants will have a diagnosis of esophageal carcinoma and residual tumor >0-1 mm from the CRM | Procedure: Esophagectomy<br>* Esophagectomy<br>|
| Circumferential resection margin (CRM)+<br>Participants will have a diagnosis of esophageal carcinoma and residual tumor at the surgical CRM | Procedure: Esophagectomy<br>* Esophagectomy<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| . Preoperative variables associated with overall survival and progression-free survival (measured from date of surgery) | Preoperative variables associated with overall survival and progression-free survival (measured from date of surgery) and the association between patient characteristics, neoadjuvant therapy, and postoperative morbidity. | Up to 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival and progression-free survival (measured from date of surgery) | Postoperative outcomes stratified by the type of esophageal cancer surgery performed. | Up to 2 years | 
| Postoperative outcomes stratified by the time between neoadjuvant therapy and surgery (i.e., delayed or immediate). |  | Up to 2 years | 
| Survival outcomes stratified by treatment modality (i.e., definitive chemoradiation therapy or trimodality treatment). |  | Up to 2 years | 
| Survival outcomes stratified by use of adjuvant therapy (i.e., adjuvant therapy or no adjuvant therapy). |  | Up to 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Esophageal Cancer, Esophagus Cancer, Memorial Sloan Kettering Cancer Center, 16-1631