Protocol No. 2016 - Calculosis- Endourology;

Study Overview
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Brief Summary
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Retrospective and prospective study on patients suffering from nephrolithiasis who undergo minimally invasive surgery of the upper excretory system; correlation between the phenotypic and genotypic aspects of the patients and the stone pathology treated with an endoscopic surgical approach.

Detailed Description
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Clinical data will be collected from patients suffering from kidney stones before and after surgery, in order to demonstrate how the endoscopic approach can not only be effective in treating kidney stones but also reduce operative complications. These data will be collected in a database in order to be able to perform statistical analyzes useful for demonstrating our theory. Furthermore, data from the surgery will be collected regarding the endoscopic instruments used and the intraoperative findings (site, size, appearance of the stone), degree of calcification of the renal papillae. All this in order to improve the therapeutic approach to patients suffering from stones and reduce the risk of recurrence over time through the identification of genetic expression patterns that predispose to the expression of the stone phenotype.

Official Title
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Retrospective and Prospective Study of Patients Suffering From Nephrolithiasis Undergoing Surgery Using a Minimally Invasive Endoscopic Approach.

Conditions
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Calculosis

Intervention / Treatment
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* Other: Observation of patients suffering from kidney stones who undergo endoscopic surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: subjects suffering from kidney stones or tumors of the upper excretory tract >= 18 years signature of informed consent Exclusion Criteria: subjects < 18 years presence of mental or physical disability that may prevent the patient from answering the questionnaires.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Calculosis patients<br>Patients suffering from kidney stones | Other: Observation of patients suffering from kidney stones who undergo endoscopic surgery<br>* Clinical data will therefore be acquired through a collection of medical history, physical examination, blood chemistry and instrumental test reports;<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical data | Medical history: patient's medical history, past surgical history, family medical history, social history, allergies, and medications; physical examination: vital signs, temperature examination, blood pressure, pulse, and respiratory rate blood chemistry and instrumental test reports: Serum PSA levels, conventional imaging | Baseline and after 6 months | 
| Eating habits | Eating habits through an ad-hoc eating habits questionnaire | Baseline and after 6 months | 
| Prostatic Function | Prostatic Function through the International Prostatic Symptoms Score questionnaire, IPSS, Scoring 0 -7, 0-7 mild symptoms, 8-19 moderate symptoms, 20-35 severe symptoms. | Baseline and after 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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calculosis, calculi, endourologia