Vascularized Inter-positional Periosteal Connective-tissue Flap Versus Collagen Membrane in Guided Bone Regeneration

Study Overview
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Brief Summary
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this study compares 2 techniques in guided bone regeneration for horizontal ridge augmentation in aesthetic zone

Detailed Description
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Guided bone regeneration is a technique for ridge augmentation using membranes The membrane of GBR is an essential component of treatment as it has some important characteristics manageability, space-making ability, and adequate mechanical, physical properties, and biocompatibility Collagen membranes are the most commonly used and can inhibit soft tissue growth in bone defects and achieve better wound healing and bone regeneration. on the other hand, a Vascularized inter-positional periosteal connective tissue flap is a flap that has been used as a substitute for the collagen membrane with promising results. Vascularized inter-positional periosteal connective tissue flap (VIPCTF) may have many advantages over traditional collagen membranes such as; high vascularity, decreased cost (as it may substitute membrane), providing an increase in soft tissue thickness, and reusability. So Evaluation of effect of vascularized interpositional periosteal connective tissue flap on horizontal ridge augmentation grafting of the anterior maxilla in comaprison with the collagen membranes

Official Title
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Vascularized Inter-positional Periosteal Connective-tissue Flap Versus Collagen Membrane in Guided Bone Regeneration in Horizontal Ridge Augmentation in Aesthetic Zone

Conditions
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Horizontal Ridge Deficiency

Intervention / Treatment
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* Procedure: Vascularized inter-positional periosteal connective tissue flap


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with a horizontal defect in anterior and premolar areas of the maxilla (aesthetic zone). Exclusion Criteria: poor oral hygiene radiation therapy of head and neck cancer intraoral soft and hard tissue lesions Heavy smoking Bone pathology

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: vascularized interpositional periosteal connective tissue flap<br>Vascularized inter-positional periosteal connective tissue flap (VIPCTF) may have many advantages over traditional collagen membranes such as; high vascularity, decreased cost (as it may substitute membrane), providing an increase in soft tissue thickness, and reusability. | Procedure: Vascularized inter-positional periosteal connective tissue flap<br>* It is a vascularized pedicled flap derived from the hard palate that can be used as a barrier to prevent in growth of soft tissue in guided bone regeneration and to increase soft tissue quantity<br>|
| Active Comparator: collagen membrane<br>Collagen membranes are the most commonly used and can inhibit soft tissue growth in bone defects, They achieve better wound healing and bone regeneration. | Procedure: Vascularized inter-positional periosteal connective tissue flap<br>* It is a vascularized pedicled flap derived from the hard palate that can be used as a barrier to prevent in growth of soft tissue in guided bone regeneration and to increase soft tissue quantity<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Amount of bone width gain (horizontal augmentation) | bone width gain is measured in millimeters by Cone beam computed tomography | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of bone formation in the bone biopsy | Area percentage of newly formed bone is measured through histomorphometric analysis | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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VIPCTF, GBR, Horizontal ridge augmentation