linjc16/ctgov huggingface dataset:
Comparison of Different Non-invasive Methods to Assess Pulse Wave Analysis

Study Overview
=================
Brief Summary
-----------------
The primary goal of the study is to compare different methods for pulse wave measurement and analysis which are cuffless and contactless. The novel measurement tools will be compared to cuff-based reference methods.

Official Title
-----------------
Vergleich Verschiedener Nicht-invasiver Verfahren Zur Pulswellenanalyse

Conditions
-----------------
Blood Pressure, Arterial Stiffness, Arrythmia

Intervention / Treatment
-----------------
* Device: Pulse wave measurement and analysis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: older than 18 years male or female sex signed informed consent. Exclusion Criteria: acute sickness which influences hemodynamic parameters arm circumference is below or above the limits for the blood pressure of the reference method (i.e. below 20 or above 40 cm)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Participants with sinus rhythm<br> | Device: Pulse wave measurement and analysis<br>* Different contact-less and cuff-less pulse wave measurements will be used and compared to cuff-based reference method.<br>|
| Participants with atrial fibrillation<br> | Device: Pulse wave measurement and analysis<br>* Different contact-less and cuff-less pulse wave measurements will be used and compared to cuff-based reference method.<br>|
| Participants with extra systoles<br> | Device: Pulse wave measurement and analysis<br>* Different contact-less and cuff-less pulse wave measurements will be used and compared to cuff-based reference method.<br>|
| Participants with heart failure with reduced ejection fraction<br> | Device: Pulse wave measurement and analysis<br>* Different contact-less and cuff-less pulse wave measurements will be used and compared to cuff-based reference method.<br>|
| Participants with mildly reduced or preserved ejection fraction<br> | Device: Pulse wave measurement and analysis<br>* Different contact-less and cuff-less pulse wave measurements will be used and compared to cuff-based reference method.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Systolic and diastolic blood pressure | Cuffless and contactless methods will be used to measure and analyze pulse wave velocity to estimate systolic and diastolic blood pressure | 3 months |
Diagnostic Importance of the C-reactive Protein From Blood and Saliva in Children With Acute Appendicitis

Study Overview
=================
Brief Summary
-----------------
Diagnosing acute appendicitis in children is still a challenge even for experienced clinicians. Failure to recognize this acute condition can result in perforation, with consequent peritonitis, or misdiagnosis can result in negative appendectomies. C-reactive protein in blood can be elavated in children with acute appendicitis. The aim of this research is to compare the diagnostic value of C-reactive protein from the blood and saliva of children with acute appendicitis and to prove wheter the analysis of biomarker from saliva as a minimally invasive procedure can be sufficient for diagnosis.

Official Title
-----------------
Diagnostic Importance of the Circulating C-reactive Protein in Blood and Saliva in Acute Appendicitis in Pediatric Patients

Conditions
-----------------
Acute Appendicitis

Intervention / Treatment
-----------------
* Diagnostic Test: Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: children with age from 5 to 17 with acute abdominal pain children with clinical signs of appendicitis Exclusion Criteria: previous diagnosis of chronic and/or malignant disease children wich had previous abdominal surgery pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with acute appendicitis<br>Patients with acute appendicitis, after surgery and with pathohistological confirmation | Diagnostic Test: Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels<br>* Blood analysis of CRP and WBC levels Saliva analysis of CRP levels<br>|
| Patients without acute appendicitis<br>Patients without acute appendicitis, after laboratory, clinical and/or radiological exclusion of acute admittance | Diagnostic Test: Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels<br>* Blood analysis of CRP and WBC levels Saliva analysis of CRP levels<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Level of CRP in blood | Levels of CRP in blood as measured by ELISA test | 72 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Level of CRP in saliva | Levels of CRP in saliva as measured by ELISA test | 72 hours |
Milrinone on Right Ventricular Strain in Cardiac Surgery

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to analyze the changes in right ventricular strain before and after milrinone administration in order to find out whether milrinone improves RV systolic performance in patients undergoing cardiac surgery.

Official Title
-----------------
Effect of Milrinone on the Right Ventricular Strain in Cardiac Surgery

Conditions
-----------------
Ischemic Heart Disease, Valvular Heart Disease

Intervention / Treatment
-----------------
* Drug: Milrinone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patient agree and provide written informed consent. patient undergoing elective cardiac surgery preoperative LV EF>50% (TTE) Exclusion Criteria: preoperative cardiac dysrhythmia preoperative IABP use of other inotropic agents

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Milrinone|giving intravenous milrinone: 50 mcg/kg loading dose by IV push over 10 minutes, then 0.375-0.75 mcg/kg/ min infusion|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1. Right ventricular strain |  | 15 min after milrinone administration | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Left ventricular strain |  | 15 min after milrinone administration | 
| Left ventricular ejection fraction |  | 15 min after milrinone administration | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Milrinone, strain, systolic function
Factors Affecting Dialysis Associated Fatigue

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to investigate the factors affecting hemodialysis-associated fatigue and their impact on the physical and emotional well-being of patients. By identifying these factors, Investigators can develop effective strategies to reduce fatigue and enhance the overall quality of life for hemodialysis patients.

Detailed Description
-----------------
Chronic kidney disease (CKD) is a significant public health issue affecting millions of individuals worldwide. Hemodialysis, the most common modality for renal replacement therapy, is a life-sustaining procedure for end-stage renal disease (ESRD) patients. Despite its benefits, hemodialysis can be associated with various complications, and one of the most commonly reported symptoms is fatigue. Hemodialysis-associated fatigue (HAF) is characterized by persistent tiredness, lack of energy, and reduced motivation, which significantly impacts the quality of life and functional capacity of patients. Several potential factors contribute to HAF, including patient-related variables, dialysis-related factors, and comorbidities. Understanding the underlying mechanisms and factors contributing to HAF is essential for improving the overall care and quality of life of hemodialysis patients. Targeted interventions to address fatigue could lead to better adherence to dialysis treatment, reduced hospitalizations, and enhanced overall well-being for this vulnerable patient population. To date, limited research has been conducted on the subject of HAF, and the available studies often have small sample sizes and diverse methodologies. Therefore, this research aims to delve into the complexities of HAF, exploring its prevalence, potential risk factors, and implications for patient outcomes.

Official Title
-----------------
Factors Affecting Dialysis Associated Fatigue

Conditions
-----------------
Dialysis; Complications

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: adult hemodialysis patients aged ≥ 18 years patients on hemodialysis for at least 3 months Exclusion Criteria: patients aged < 18 years patients with acute kidney injury patients with cognitive impairment or inability to provide informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Factors affecting dialysis associated fatigue | The aim of this study is to investigate the factors affecting hemodialysis-associated fatigue and their impact on the physical and emotional well-being of patients. | baseline |
Study of Hydration Levels in Sports and Non-sports Schoolchildren (EHC)

Study Overview
=================
Brief Summary
-----------------
New knowledge regarding the negative impact of poor hydration on health highlights the need to provide recent epidemiological data on the water intake of the French population, especially among middle school students, a group that has been minimally studied until now. Given the crucial role of adequate hydration in sports performance, it is essential to assess fluid intake and hydration habits among middle school students, who often engage in intense physical activities. The primary outcome of this study is to evaluate whether the proportion of middle school students hydrating adequately according to current recommendations is higher among those engaging in moderate to intense sports compared to those who do little or no sports. The goal is to determine if daily fluid intake is significantly influenced by physical activity among this population. To achieve this, investigators have developed a questionnaire to gather information on the physical activity levels of middle school students, their daily hydration habits, and their liquid intake in relation to their sports activities, using appropriate visuals. This study involves distributing the questionnaire in two middle schools in Brittany between November 2023 and January 2024.

Official Title
-----------------
Study of Hydration Levels in Sports and Non-sports Schoolchildren

Conditions
-----------------
Hydration

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Middle school students with little or no sports involvement and middle school students with a moderate to intense level of physical activity Exclusion Criteria: Refusal of the middle school student to participate and parental opposition to their child's participation in this research

Ages Eligible for Study
-----------------
Minimum Age: 9 Years
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of middle school students adhering to current hydration recommendations among both athletic and non-athletic middle school students | Response to the questionnaire | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of middle school students adhering to current hydration recommendations | Response to the questionnaire | baseline | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Beverage, Sports, Children, Middle school students, Adolescents, dehydration, Water
Watering of the Eyes Following Uneventful Phacoemulsification Cataract Surgery

Study Overview
=================
Brief Summary
-----------------
An observational study aiming to assess the incidence and possible causes of post phacoemulsification watery eye.

Detailed Description
-----------------
This study will be conducted on patients who will undergo cataract extraction at Sohag university hospitals to evaluate the incidence of watery eyes in patients after phacoemulsification by one week , one month and three month. Study Design: observational study. Inclusion Criteria: Patients with age-related cataract. Exclusion Criteria: patients with watering of eyes or ocular surface diseases or watering of the eyes . patients with previous ocular surgeries. patients with glaucoma, uveitis, corneal or retinal pathologies. Preoperative Evaluation: Each patient will be subjected to the following: Detailed history taking and full ophthalmological examination. Fluorescein dye disappearance test. Syringing and probing. Schirmer's test. Tear break up time test. Measurement of punctal diameter by AS-OCT. Operative procedures: regional anesthesia. phaco technique : stop and shop. cumulative dissipated energy (CDE ) &fluid flow. Follow-up regimen: will be as follows: patients will be examined after surgery on: 1st postoperative week, 1st month, 3rd month. The following will be recorded for each patient: symptoms of watery eyes, visual acuity, IOP, slit lamp examination. dye disappearance test. Schirmer's test. tear break up time test. anterior segment OCT.

Official Title
-----------------
Watering of the Eyes Following Uneventful Phacoemulsification Cataract Surgery

Conditions
-----------------
Watery Eyes

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with age related cataract. Exclusion Criteria: patients with watering of the eyes or ocular surface disease. patients with previous ocular surgeries . patients with glaucoma, uveitis, cornealor retinal pathologies.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assess the incidence and possible causes of post phacoemulsification watery eye. | Patients are examined preoperatively and postoperatively by flourescein disappearance test, probing and syringing, schirmer's test,tear breakup time test and anterior segment optical coherence tomography to detect incidence and causes of post phacoemulsification watery eye. | Five months |
Pulmonary Vein (PV) Imaging by Intracardiac Echography (ICE) After Ablation

Study Overview
=================
Brief Summary
-----------------
To test the hypothesis that structural changes documented by ICE after pulmonary vein deconnection by RF can predict AF recurrences

Detailed Description
-----------------
Patient undergoing first RF ablation for sympomatic paroxysmal atrial fibrillation will be enrolled. ICE visualization of PV antra before and after PV deconnection (electrophysiological endpoint). Changes in echogenicity as documented by ICE will be evaluated by a dedicated software and correlated to long term recurrences

Official Title
-----------------
Pulmonary Vein Imaging by ICE After Atrial Fibrillation Ablation to Predict Recurrences

Conditions
-----------------
Atrial Fibrillation Recurrent

Intervention / Treatment
-----------------
* Device: Atrial fibrillation ablation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Atrial fibrillation ablation candidates Exclusion Criteria: Previous catheter ablation Persistent atrial fibrillation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Atrial fibrillation ablation|Pulmonary vein deconnection. PV antra visualization by ICE|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Atrial fibrillation recurrences | Recurrences of atrial fibrillation at 12 months follow up despite pulmonary vein deconnection | 12 months |
Prospective Assessment of Rejection in Kidney Transplant (PARK)

Study Overview
=================
Brief Summary
-----------------
The PARK study is a multi-center observational study to assess the performance of the QSant test with kidney biopsy. QSant is a test based on 6 urinary biomarkers that is used for the evaluation and management of acute rejection in renal allograft recipients with clinical suspicion of rejection.

Detailed Description
-----------------
Non-randomized, unblinded observational study to collect urine samples, coincident allograft biopsy results, and relevant clinical data to evaluate the QSant test. Participants will be recruited prior to or on the day of an already scheduled kidney biopsy. Urine samples will be collected before biopsy (protocol and for-cause).

Official Title
-----------------
Prospective Assessment of Rejection in Kidney Transplant (PARK)

Conditions
-----------------
Kidney Transplant Failure and Rejection

Intervention / Treatment
-----------------
* Other: QSant


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Kidney transplant recipient ≥ 18 years who are scheduled for kidney biopsy. Kidney biopsy scheduled on a date > 14 days post-transplant Able to understand risks and requirements of participation and provide informed consent Willing and able to comply with the study requirements Exclusion Criteria: Inability to provide a voided urine sample per collection protocol Urological abnormalities such as catheters, augmented bladder, ileal conduits, mitrofanoff, and vesicostomy History of or current multi-organ transplant

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: QSant|QSant™ is a needle free urine test collected in-home or in-clinic to aid in the evaluation and management of kidney transplant recipients' allograft status. QSant evaluates 6 kidney-specific biomarkers.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Collect coincident urine specimens and biopsy results from participants | Collect urine sample using QSant kit for adult kidney transplant recipients | Prior to biopsy | 
| QScore specificity and sensitivity in relation to kidney biopsy | Evaluate the QSant algorithm performance in terms of sensitivity, specificity, and accuracy | Prior to biopsy | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
kidney transplant, kidney biopsy, allograft rejection
Median Nerve Function During Phalen's Test

Study Overview
=================
Brief Summary
-----------------
This study will use electromyography and nerve conduction studies to evaluate median nerve function during the Phalen's wrist flexion test in different wrist positions.

Detailed Description
-----------------
The Phalen's test is commonly used to assess carpal tunnel syndrome. However, it is unclear which wrist position during this test best isolates median nerve function. This study will measure thenar muscle activation and median nerve conduction in 30 healthy participants performing the Phalen's test. Different wrist flexion angles will be evaluated to determine which position optimally targets the median nerve. Results may enhance utilization of the Phalen's test in clinical practice and research.

Official Title
-----------------
Electrophysiological Assessment of the Median Nerve During the Phalen's Test for Carpal Tunnel Syndrome

Conditions
-----------------
Carpal Tunnel Syndrome

Intervention / Treatment
-----------------
* Diagnostic Test: Phalen's wrist flexion test


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy adults aged 18-45 years No history of hand/wrist disorders Exclusion Criteria: Contraindications to EMG or NCV Neurological or muscular disorders

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Adults<br>30 healthy adult participants aged 18-45 years performing the Phalen's wrist flexion test | Diagnostic Test: Phalen's wrist flexion test<br>* The Phalen's test will be performed at different wrist flexion angles from 0 to 90 degrees.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Thenar Muscle Activation | Mean EMG activity of the thenar muscles during the Phalen's test at different wrist angles. Measured in microvolts (μV). | Baseline | 
| Median Nerve Conduction Velocity during Phalen's Test | Median nerve conduction velocity (measured in meters per second, m/s) assessed using surface electrodes at the wrist and elbow during the Phalen's test wrist flexion maneuver. Measured bilaterally at each wrist flexion angle during a single study visit. | Baseline | 
| Median Nerve Distal Latency during Phalen's Test | Median nerve distal latency (measured in milliseconds, ms) assessed using surface electrodes over the abductor pollicis brevis and stimulating the median nerve at the wrist during the Phalen's test. Measured bilaterally at each wrist flexion angle during a single study visit. | Baseline |