Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?

Study Overview
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Brief Summary
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This study aims to explore the potential correlation between decreased ovarian reserve and previous history of early miscarriage.

Detailed Description
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By investigating the prevalence of low ovarian reserve (LOR) in populations with specific reproductive histories (such as recurrent pregnancy loss, G0, and ectopic pregnancy), as well as the aneuploidy rates of embryos produced with Preimplantation Genetic Testing for Aneuploidies (PGT-A), Investigators can better understand how LOR impacts fertility outcomes in these populations. This information can be used to inform clinical decision-making, such as whether participants with LOR should consider alternative or whether they would benefit from additional interventions to improve ovarian function. Ultimately, by improving our understanding of how LOR impacts fertility outcomes in specific populations, Investigators can help to improve the overall success rates of infertility treatment, reduce anxiety, and distress, and help participants achieve goals of becoming parents.

Official Title
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Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages? A Prospective Observational Study

Conditions
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Infertility, Female, Miscarriage, Miscarriage, Recurrent, IVF

Intervention / Treatment
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* Diagnostic Test: Transvaginal ultrasound
* Diagnostic Test: Blood test AMH


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1. All participants with at least 1 previous pregnancy, who are assessed in one of our clinics (ART Fertility Clinics Abu Dhabi, Al Ain, Dubai) Exclusion Criteria: Severe male factor (azoospermia, cryptozoospermia, severe oligoasthenoteratozoospermia (OAT)) Severe Endometriosis and adenomyosis based on positive anamnesis or ultrasound performed in our center during the first consultation Uterine abnormalities (e.g. fibroids, different degrees of uterine septum), diagnosed by ultrasound History of ovarian surgery, chemotherapy, or radiation therapy Known genetic disorder or chromosomal abnormality BMI >40Kg/m2 Currently using hormonal contraception or hormone replacement therapy
Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| AMH <1.3, at least 1 pregnancy or at least 1 miscarriage<br>Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications. | Diagnostic Test: Transvaginal ultrasound<br>* Transvaginal ultrasound for antral follicle count (AFC) performed on the day of first consultation<br>Diagnostic Test: Blood test AMH<br>* Measurement of AMH performed on the day of first consultation<br>|
| AMH <1.3, at least 1 pregnancy and no miscarriage<br>Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications. | Diagnostic Test: Transvaginal ultrasound<br>* Transvaginal ultrasound for antral follicle count (AFC) performed on the day of first consultation<br>Diagnostic Test: Blood test AMH<br>* Measurement of AMH performed on the day of first consultation<br>|
| AMH ≥ 1.3, at least 1 pregnancy or at least 1 miscarriage<br>Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.ons. | Diagnostic Test: Transvaginal ultrasound<br>* Transvaginal ultrasound for antral follicle count (AFC) performed on the day of first consultation<br>Diagnostic Test: Blood test AMH<br>* Measurement of AMH performed on the day of first consultation<br>|
| AMH ≥1.3, at least 1 pregnancy and no miscarriage<br>Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications. | Diagnostic Test: Transvaginal ultrasound<br>* Transvaginal ultrasound for antral follicle count (AFC) performed on the day of first consultation<br>Diagnostic Test: Blood test AMH<br>* Measurement of AMH performed on the day of first consultation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| AMH | Anti-Müllerian Hormone Test | 1 day | 
| AFC | Antral follicle count | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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miscarriage, infertility, IVF