Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals

Study Overview
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Brief Summary
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The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.

Official Title
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Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy

Conditions
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Dietary Supplementation

Intervention / Treatment
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* Dietary Supplement: Grape seed extract


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers (SBP < 120 mmHg, DBP < 80 mmHg) Exclusion Criteria: cardiovascular and/or pulmonary disease, musculoskeletal disorders medications that prevent the safe completion of the exercise protocol

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Randomized double blind grape seed extract design<br>Grape seed extract | Dietary Supplement: Grape seed extract<br>* Acute effect of dietary supplementation with GSE on hemodynamic responses during static exercise and muscle metaboreflex and during cycling exercise.<br>|
| Placebo Comparator: Control<br>Placebo (starch) | Dietary Supplement: Grape seed extract<br>* Acute effect of dietary supplementation with GSE on hemodynamic responses during static exercise and muscle metaboreflex and during cycling exercise.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Systolic blood pressure (mmHg) by sphygmomanometer | Measured from the brachial artery | 24 hours | 
| Diastolic blood pressure (mmHg) by sphygmomanometer | Measured from the brachial artery | 24 hours | 
| Mean arterial pressure (mmHg) | calculated (MAP = (SBP-DBP)/3 + DBP | 24 hours | 
| Heart rate (bpm) | measured using Physio Flow (non-invasive device) | 24 hours | 
| Stroke volume (ml) | measured using Physio Flow (non-invasive device) | 24 hours | 
| Cardiac output (l/min) | calculated: HR (bpm) x SV (ml) | 24 hours | 
| Total peripheral resistance (mmHg/l/min) | calculated: MAP (mmHg) / CO (l/min) | 24 hours |