Aortoiliac Stenosis in Kidney Transplantation

Study Overview
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Brief Summary
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The impact of aortoiliac stenosis on kidney transplant patients remains unclear. This study aims to investigate the safety and efficacy of kidney transplantation in patients with aortoiliac stenosis.

Detailed Description
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Kidney transplantation is the optimal treatment for end-stage renal disease (ESRD). Unfortunately, not all ESRD patients are eligible for kidney transplantation. Aortoiliac stenosis, an increasingly common type of peripheral arterial disease in ESRD patients, is considered as relative contra-indication for kidney transplantation. There are several reasons for concern, such as the complexity of the vascular anastomosis and inferior life expectancy. Consequently, it is still debated whether patients with aortoiliac stenosis would benefit from kidney transplantation. This study aimed to supplement current literature on the safety and efficacy of kidney transplantation in patients with aortoiliac stenosis. To achieve this, all patients undergoing kidney transplantation in Erasmus Medical Center between January 2010 and December 2020 were enrolled, and propensity score matching was used to minimize confounding factors. Additionally, long-term graft function was investigated to evaluate the impact of stenosis on graft function.

Official Title
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Safety and Efficacy of Kidney Transplantation in Patients With Aortoiliac Stenosis

Conditions
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Aorto-Iliac Arterial Stenosis, Peripheral Arterial Disease, Kidney Transplant Failure

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who underwent kidney transplantation in the Erasmus Medical Center between January 2010 and December 2020 Exclusion Criteria: Patients who were under 18 years at transplantation Patients who underwent combined organ transplantation Patients who had no follow-up

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No-stenosis group<br>Patients who had no pre-existing aortoiliac stenosis before kidney transplantation. | |
| TASC A/B stenosis<br>Patients who had TASC A or B aortoiliac stenosis before kidney transplantation. | |
| TASC C/D stenosis<br>Patients who had TASC C or D aortoiliac stenosis before kidney transplantation. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| patient survival | All-cause death after kidney transplantation till the end of follow-up. | From the date of kidney transplantation till death or January 2023. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| death-censored graft survival | Death-censored graft survival was defined as the time from transplant to graft failure, with censoring for death with a functioning graft. | From the date of kidney transplantation till death or January 2023. | 
| Graft function | Estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. | From the date of kidney transplantation till death or January 2023. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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aortoiliac arterial stenosis, peripheral arterial disease, kidney transplantation, outcomes