Middle Age muScle Krill Study

Study Overview
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Brief Summary
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This study will determine the effect of 6 months of supplementation with krill oil on muscle strength and mass in middle-aged adults. The study hypothesis is that krill oil supplementation will increase muscle strength and mass in middle-aged adults.

Official Title
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The Effect of Krill Oil Supplementation on Muscle Function and Mass in Middle-aged Adults: A Randomised Controlled Trial

Conditions
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Sarcopenia

Intervention / Treatment
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* Dietary Supplement: Krill oil
* Dietary Supplement: Vegetable oil


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Be 35-60 years old Have a BMI of less than 35kg/m2 Exclusion Criteria: People with diabetes, severe cardiovascular disease, seizure disorders, uncontrolled hypertension (>150/90mmHg at baseline measurement), cancer or cancer that has been in remission <5 years, ambulatory impairments which would limit the ability to perform assessments of muscle function, dementia, on anticoagulant therapy, and/or taking medication known to affect muscle (e.g., steroids). People who have allergies to seafood, and/or regular consumption of more than 1 portion of oily fish per week. People who perform regular (>1 day/week) resistance exercise training.

Ages Eligible for Study
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Minimum Age: 35 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: 1:1 basis
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Krill oil 4g/day for 24 weeks | Dietary Supplement: Krill oil<br>* Superba krill oil<br>|
| Placebo Comparator: Placebo<br>Vegetable oil 4g/day for 24 weeks | Dietary Supplement: Vegetable oil<br>* Mixed vegetable oil<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in knee extensor maximal isometric torque ( MVC) | Knee extensor maximal isometric torque measured during a maximal voluntary contraction | Change from baseline to 24 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in fat mass | Whole body fat mass measured by measured via bio-electrical impedance | Change from baseline to 24 weeks | 
| Change in lean mass | Whole body lean mass measured by measured via bio-electrical impedance | Change from baseline to 24 weeks | 
| Change in omega-3 levels | Red blood cell omega-3 levels | Change from baseline to 24 weeks | 
| Change in Grip strength | Grip strength measured with a hand held dynamometer | Change from baseline to 24 weeks | 
| Change in Muscle thickness | Vastus lateralis muscle thickness measured by ultrasound | Change from baseline to 24 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Krill oil, Muscle strength, Muscle mass, Middle-aged