Detection of Ileoanal Pouch/Reservoir Adenomas

Study Overview
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Brief Summary
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The detection of adenomas is the basis for the follow-up of patients with familial adenomatous polyposis, after colectomy, with a remnant rectum or an ileal pouch. The optimal method for the adenomas detection is not defined yet. Despite the proven effectiveness of indigo-carmine in different indications dye chromoendoscopy is not used in a consensual way at the international level. The situation of the ileal pouch is specific as adenomas have a usually flat shape and are much more difficult to identify than in the situation of a remnant rectum, even in the situation of > 5 mm adenomas that should be resected. Our hypothesis is that indigo-carmine can improve adenomas detection, including > 5 mm adenomas, in patients with a an ileal pouch after colectomy improving the effectiveness of surveillance programs and potentially reducing the risk of cancer in this population.

Official Title
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Detection of Ileoanal Pouch/ Reservoir Adenomas by Routine Chromoendoscopy With Indigocarmine

Conditions
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Adenomatous Polyps

Intervention / Treatment
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* Procedure: Adenomas detection rate with the different observation methods


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with familial adenomatous polyposis Ileo-anal anastomosis with pouch reservoir Quality of the final preparation = 3 (excellent) on the studied area Films made under optimal conditions for the 3 staining methods Exclusion Criteria: Patient with no familial adenomatous polyposis Patient without Ileo-anal anastomosis reservoir Insufficient quality of the final preparation <3 Absence of films made under optimal conditions for the 3 staining methods

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Ileoanal pouch adenomas detection assessment<br>Every patient who needs follow up lower digestive examination for familial adenomatous polyposis after colectomy can join this study with ileal pouch adenomas detection by experienced endoscopist. | Procedure: Adenomas detection rate with the different observation methods<br>* Films performed in white light high definition, NBI and indigo-carmine dye, will be compared blindly to detecte number of adenomas with the different observation methods<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Average number of ileal pouch/reservoir adenomas | Average number of ileal pouch/reservoir adenomas detected according to the endoscopic mode (staining or not, virtual or not) based on a paired review of the films with final consensus in case of discordance | 6 months after colonoscopy | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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familial adenomatous polyposis, Ileoanal pouch/reservoir, adenomas, chromoendoscopy, indigocarmine, colectomy