Changes in Resting Metabolic Rate Following Orthopedic Surgery

Study Overview
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Brief Summary
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This project is intended to determine the magnitude and duration of RMR changes in patients receiving orthopedic surgery. The result will help to guide postoperative nutrition recommendations in patients receiving orthopedic surgery.

Detailed Description
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Surgery produces a catabolic response in the body that shifts metabolism from glucose to fat and protein. Despite no studies examining ACLR, studies of other orthopedic surgeries demonstrate increased postoperative energy expenditure, as well as a shift to beta-oxidation. Additionally, in most patients, these changes reverted to baseline within six weeks, although a subset of patients did not return to baseline until beyond 12 weeks. This project will improve our understanding of magnitude and duration of RMR changes following orthopedic surgery, and the subsequent perioperative dietary suggestions that should be made to improve patient outcomes. Currently, postoperative dietary suggestions are not surgery nor patient specific. Determining how orthopedic surgery effects RMR will help to personalize perioperative treatment, rehabilitation, and recovery. Better understanding the change in RMR following orthopedic surgery and implementing more accurate dietary modifications will help to ensure positive outcomes and control of infection following orthopedic surgery.

Official Title
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Changes in Resting Metabolic Rate Following Orthopedic Surgery

Conditions
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Metabolism; Disorder, Postprocedural, Resting Metabolic Rate, Post Operative Nutrition

Intervention / Treatment
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* Other: Pre-surgical nutrition, hydration, RMR, and body composition assessments
* Other: Post-surgical nutrition, hydration, RMR and body composition assessments


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Any individual over 15 undergoing an orthopedic surgery. Exclusion Criteria: Pregnant female < 15 years old

Ages Eligible for Study
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Minimum Age: 15 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Male<br>50 male subjects undergoing orthopedic surgery. | Other: Pre-surgical nutrition, hydration, RMR, and body composition assessments<br>* Urine sample, InBody device platform, Metabolic cart with hood to collect RMR.<br>Other: Post-surgical nutrition, hydration, RMR and body composition assessments<br>* Same as pre-surgical tests at 1 week, 3 weeks, 6 weeks, and 12 weeks follow up time points.<br>|
| Female<br>50 female subjects undergoing orthopedic surgery | Other: Pre-surgical nutrition, hydration, RMR, and body composition assessments<br>* Urine sample, InBody device platform, Metabolic cart with hood to collect RMR.<br>Other: Post-surgical nutrition, hydration, RMR and body composition assessments<br>* Same as pre-surgical tests at 1 week, 3 weeks, 6 weeks, and 12 weeks follow up time points.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine the magnitude of the change in RMR of patients receiving orthopedic surgery. | RMR = (9.99 X actual weight*)+ (6.25 X height*) - (4.92 X age) - 161*use weight in kilograms (kilogram), height in centimeters (cm). | 12 weeks | 
| To observe the amount of time it takes the RMR to return to baseline. | calculation in number of weeks | 12 weeks |