Clinical Characteristics and Prognosis of Aortic Dissection in China (CLASSIC)

Study Overview
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Brief Summary
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This study will construct a retrospective-prospective long-term follow-up cohort and management system for aortic dissection through a multicentre collaborative network. This study aims to investigate the disease characteristics, progression patterns, clinical features, natural course and factors affecting the disease course and prognosis of patients with aortic dissection by retrospectively collecting data and prospectively enrolling patients.

Detailed Description
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This study aims to construct a retrospective-prospective long-term follow-up cohort and management system for aortic dissection through a multicentre collaborative network. The duration of the study will be divided into retrospective and prospective components. The retrospective study will collect cases of aortic dissection of different aetiologies from 2003-2022; the prospective study is expected to collect cases of aortic dissection from 2022-2030. The study is expected to assess the disease characteristics, progression patterns, clinical features, natural course and long-term prognosis of aortic coarctation.

Official Title
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Clinical Characteristics and Prognosis of Aortic Dissection in China (CLASSIC): a National, Multicenter, Retrospective-prospective, Cohort Study

Conditions
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Aortic Dissection

Intervention / Treatment
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* Other: Observational


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18-80 years; Meet diagnostic criteria for aortic dissection. Exclusion Criteria: Age <18 years or >80 years; Women who are pregnant and breastfeeding; Patients and their families refuse or are unable to sign the informed consent form.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Aortic dissection group<br>Patients diagnosed with aortic dissection at any of the centres and regularly consulted and followed up. | Other: Observational<br>* No interventions will be given to patients.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of post-operative survival rate | Post-operative survival rate of patients after aortic dissection surgery in 3, 6, 9 month and 1, 2, 3, 4, 5 year. The survival situation will be assessed by telephone follow-up. | 3, 6, 9 month and 1, 2, 3, 4, 5 year after the surgery. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of the incidence of MACCE | Major adverse cardio-cerebrovascular events included myocardial infarction, stroke, revascularization and all-cause death. The occurrence of MACCE will be assessed by telephone follow-up and medical records. | 3, 6, 9 month and 1, 2, 3, 4, 5 year after the surgery. | 
| Incidence of any complications | Any complications diagnosed by doctors. The occurrence of complications will be decided by medical records. | 5 years after the surgery. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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aortic dissection, clinical characteristics, prognosis