Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness

Study Overview
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Brief Summary
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Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness based on Electroencephalography and Auditory Event-related Potentials

Official Title
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Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness Based on Electroencephalogram and Event-related Potential

Conditions
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Consciousness Disorder

Intervention / Treatment
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* Drug: Different drug dosage


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 - 65 years old, native Chinese speaker, dextromanuality; Chronic disorder of consciousness; Spinal cord electrical stimulator implantation under general anesthesia; Signed informed consent. Exclusion Criteria: Continuous sedation was administered within 72 hours prior to the study; Open head injury, parenchymatectomy and other damage of brain structural integrity; The intracranial compliance decreased due to hydrocephalus and swelling; Known hearing impairment; Airway stenosis and various causes of severe ventilation or ventilation dysfunction; Known or suspected cardiac dysfunction; Allergic to intravenous general anesthetics; Associated with other mental or neurological diseases; Other reasons are not suitable to participate in this study.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Propofol<br>Intravenous infusion | Drug: Different drug dosage<br>* Choice of Anesthesia<br>|
| Dexmedetomidine<br>Intravenous infusion | Drug: Different drug dosage<br>* Choice of Anesthesia<br>|
| Esketamine<br>Intravenous infusion | Drug: Different drug dosage<br>* Choice of Anesthesia<br>|
| Sevoflurane<br>Inhalation anesthesia | Drug: Different drug dosage<br>* Choice of Anesthesia<br>|
| Remifentanil<br>Intravenous infusion | Drug: Different drug dosage<br>* Choice of Anesthesia<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EEG Spectral Characteristics | Characteristics of EEG power spectrum(for 1-30 Hz) in patients with chronic consciousness disorder under different doses of drugs | During the trial(up to 3 hours for each subject) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cortical Connectivity | Characteristics of the weighted phase lag index in patients with chronic consciousness | During the trial(up to 3 hours for each subject) | 
| Derived quantitative indicators | Characteristics of EEG derived quantitative indicators with chronic consciousness disorder during anesthesia recovery | During the trial(up to 3 hours for each subject) | 
| Characteristics of sleep | Characteristics of sleep cycle in patients with chronic disorders of consciousness | During the trial(up to 24 hours for each subject) | 
| Dynamic Patterns of Cortical Connectivity | The time-frequency characteristics of the weighted phase lag index in patients with chronic disorders of consciousness | During the trial(up to 3 hours for each subject) | 
| Rate of patients recovered consciousness after surgery | Rate of patients recovered consciousness 30 days, 90 days, 180 days after surgery | During the trial(through study completion, 180 days) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Prolonged Disorders of Consciousness, Propofol, Brain Functional connectivity, Electroencephalography