Mechanism for Exercise to Delay Cardiac Aging

Study Overview
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Brief Summary
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The goal of this clinicaltrial is to assess and compare isokinetic performance, surface electromyography, laboratory parameters, and cardiorespiratory function both before and after engaging in vigorous intermittent lifestyle physical activity(VILPA) within a healthy population. The main question it aims to answer is: [1] Does VILPA yield effective outcomes? Throughout the course of the trial, participants will engage in a simulated regimen of vigorous intermittent lifestyle physical activity for a duration of 8 weeks. The efficacy of the exercise protocol will be quantified and evaluated through the utilization of a wearable device.

Official Title
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The αKlotho Protein-mediated NLRP3/Caspase-1/GSDMD Pathway Counteracts Myocardial Stunning: a Novel Mechanism for Exercise to Delay Cardiac Aging

Conditions
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Activity, Motor, Health Behavior

Intervention / Treatment
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* Other: Vigorous intermittent lifestyle physical activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy Adults No exercise habits (more than 3 months) Exclusion Criteria: Exercising ≥ 3 times per week; the presence of chronic diseases, such as hypertension, hyperglycemic states, etc; have conducted an exercise program in the past three months.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| intervention group<br>The intervention measures encompass the implementation of simulated vigorous intermittent lifestyle physical activity for all participants. The specific exercise regimen involves performing rope jumping activities three times a day, with each session aimed at surpassing the exercise threshold (not conducted in a continuous manner), where the heart rate should exceed 160 beats per minute. This routine will be undertaken five times a week, continuously for a span of 8 weeks. | Other: Vigorous intermittent lifestyle physical activity<br>* The specific exercise regimen involves performing rope jumping activities three times a day, with each session aimed at surpassing the exercise threshold (not conducted in a continuous manner), where the heart rate should exceed 160 beats per minute. This routine will be undertaken five times a week, continuously for a span of 8 weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Isometric Strength Test | Isokinetic muscle strength testing with the Isomed 2000 | 15 minutes | 
| Surface electromyography |  | 30 minutes | 
| Exercise Flat Test | cardiopulmonary function | 30 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fasting glucose |  | 5 minutes | 
| Blood lipid |  | 5 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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vigorous intermittent lifestyle physical activity, wearable device, isokinetic performance