Ozonated Water in Treatment of Denture Stomatitis

Study Overview
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Brief Summary
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The effect of Ozonated water on the treatment of oral stomatitis associated with complete denture wearer in comparison to Chlorhexidine mouthwash

Detailed Description
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Compete denture wearers having oral denture stomatitis were divided into two groups. group I used Ozonated water while group II used Chlorhexidine mouthwash. The growth of Candida albicans, the degree inflammation and pain grade were evaluated before starting the treatment then every week till one month. Also

Official Title
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Effect of Ozone Water in Treatment of Denture Inflammation

Conditions
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Denture Stomatitis

Intervention / Treatment
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* Other: Ozonated water
* Other: Chlorhexidine mouthwash


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Completely edentulous male patients wearing heat cured acrylic resin removable prosthesis. Patients having denture associated oral stomatitis. Healthy patients free of any systemic diseases. Exclusion Criteria: Smoker patients. Patients suffering from any auto immune or systemic diseases, Temporo-mandibular joint disorder ( TMJ disorders and parafunctional oral habits. Patients with a history of radiotherapy or chemotherapy. Patients having oral lesions.
Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Two groups ( complete denture wearers with oral stomatitis). Group I treated with ozonated water while group II treated with chlorhexidine mouthwash.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group I patients treated with ozonated water<br>The patients were used ozonated water as mouth wash for treatment of denture associated oral stomatitis. | Other: Ozonated water<br>* ozonated water was prepared with a concentration of (2-4 mg/l) ozone for 1 min. in a 25 mg of double distilled water 37o C employing an Ozone generator (Ozone generator type N 1888A, China.)<br>|
| Active Comparator: Group II patients treated with chlorhexidine mouthwash<br>The patients were used chlorhexidine mouth wash for treatment of denture associated oral stomatitis | Other: Chlorhexidine mouthwash<br>* Commercial available chlorhexidine mouthwash in the market was used.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Candida albicans colonies | The number of Candida albicans forming units (CFU) was used to assess the effect of two types of treatments. | day one, 7th day, 14th day and 30th day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| -Evaluation of inflammation and pain grade | - Evaluation of inflammation and pain grade by questionnaire | day 1, and 30th day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ozonated water, denture stomatitis, Chlorhexidine mouthwash