The Effect of Hyaluronic Acid Gel on Relieving Post-Implantation Pain

Study Overview
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Brief Summary
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Few previous studies have employed HA in the implant socket; instead, the majority have applied it topically to the area around dental implants after they have been placed. The application was done after suturing in these investigations. Therefore, the goal of the current study was to inject HA into the implant socket and onto the alveolar bone prior to implant insertion and suturing in order to preserve the HA for an extended period of time. This study aims to use a visual analog scale (VAS) on the first, third, and tenth days following the surgical intervention to assess the efficacy of employing HA in dental implants in terms of pain reduction that may accompany dental implant surgery.

Official Title
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Evaluation of the Efficacy of a Hyaluronic Acid Gel in Relieving Post-Implantation Pain: A Split-Mouth Randomized Controlled Trial

Conditions
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Implant Complication

Intervention / Treatment
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* Biological: Hyaluronic Acid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: bilateral tooth loss with a sufficient amount of bone volume no general problems good oral health age between 20 and 60 years Exclusion Criteria: the use of immunosuppressive drugs and corticosteroids for long periods the existence of serious systemic disorders contraindications for local anesthesia or oral surgery pregnant women and nursing mothers patients receiving chemotherapy or radiation alcoholics and heavy smokers.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Split mouth design
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Hyaluronic acid injection<br>The hyaluronic acid will be injected into the implant socket before implantation. | Biological: Hyaluronic Acid<br>* This material will be injected into the prepared impact socket prior to inserting the implant. This injection will be done inside the socket as well as on the periphery of the socket.<br>|
| No Intervention: Traditional treatment<br>The socket will be prepared in the normal manner without being injected with any material. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in the Perception of pain | This will be measured using a numeric rating scale. Patients will be asked to indicate the level of pain they perceive on a scale from 1 to 10. The intensity of pain is going to be classified according to the following categories: 0 = no pain, 1-3 = mild pain, 3-6 = moderate pain, and 6-10 = severe pain. | First assessment: at 24 hours following the surgical procedure. Second assessment: at 72 hours following the surgical intervention. Third assessment will be made on the tenth day following the surgical intervention |