linjc16/ctgov huggingface dataset:
Molar Incisor Malformation in Egypt

Study Overview
=================
Brief Summary
-----------------
The aim of the current study is to assess the prevalence of molar incisor malformation in Fayoum-Egypt.

Detailed Description
-----------------
Localized developmental radicular dysplasia is a rare finding. This radicular formation arrest may be due to traumas, infections, radiation therapy, chemotherapy, or idiopathic. Molar Incisor Malformation is a condition characterized by arrested or altered radicular development of first permanent molars. Roots may be thin, short, or totally missing. In some patients, there are constrictions located in the cervical part of the crown of the permanent incisors. There are also cases where the roots of the second primary molars are affected. MIM could also have been mistaken for a consequence of severe root resorption, or dentine dysplasia prior to its initial description. This unique deformity, regardless of its nomenclature, presents previously undescribed clinical features and it is quite difficult to get a successful conservative treatment result. The aim of the current study is to assess the prevalence of this rare condition in Fayoum-Egypt.

Official Title
-----------------
Prevelance of Molar Incisor Malformation in Egypt

Conditions
-----------------
Paediatric Dentistry

Intervention / Treatment
-----------------
* Other: Molar incisor malformation presence


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Panoramic radiographs for older than nine-year-old patients, having completely developed first permanent molars Exclusion Criteria: Panoramic radiographs with missing first permanent molars or pathological lesions which may cause root resorption

Ages Eligible for Study
-----------------
Minimum Age: 9 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>older than 9-year-old patients, with panoramic radiographic images showing the first permanent molars | Other: Molar incisor malformation presence<br>* the presence of radiographic features of molar incisor malformation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| molar incisor malformation | the presence of root malformation to indicate the diagnosis of molar incisor malformation | Day 1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
molar-incisor malformation, developmental malformation
The Use of Standing Powered Wheelchairs in Spinal Cord Injury

Study Overview
=================
Brief Summary
-----------------
The purpose of this study was to explore the experiences of standing powered wheelchair users with spinal cord injury.

Detailed Description
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There is limited research exploring the comfort, satisfaction, adverse effects, need for repair, and benefit in terms of secondary complications in standing powered wheelchair users with spinal cord injury. The purpose of this study was to explore the experiences of standing powered wheelchair users with spinal cord injury.

Official Title
-----------------
The Use of Standing Powered Wheelchairs in Individuals With Spinal Cord Injury

Conditions
-----------------
Spinal Cord Injuries

Intervention / Treatment
-----------------
* Other: standing powered wheelchair evaluation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Ages 18-70 Post-spinal cord injury period > 1 year Exclusion Criteria: - Having cognitive impairment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| standing powered wheelchair<br>standing powered wheelchair evaluation | Other: standing powered wheelchair evaluation<br>* standing powered wheelchair evaluation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Wheelchair satisfaction | The patients' level of satisfaction with the features of the standing powered wheelchair will be evaluated with a 5-point Likert scale (from (1) not satisfied at all to (5) very satisfied). Dissatisfaction reason will be noted. | through study completion, an average of one month | 
| Wheelchair comfort | The patients' overall comfort level while using the standing powered wheelchair and the comfort level in some regions of the body (e.g. back, arms) in the standing position will be evaluated with a 5-point Likert scale (from (1) not satisfied at all to (5) very satisfied). | through study completion, an average of one month | 
| Wheelchair repair | Participants will be asked whether the standing powered wheelchair needs repairs and the area repaired. | through study completion, an average of one month | 
| Adverse and positive experiences | Participants will be asked about their adverse and positive experiences with the use of standing powered wheelchair | through study completion, an average of one month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
standing powered wheelchair, satisfaction, secondary complication, spinal cord injury
Correlation Analysis Between Corneal Biomechanics and Anterior Segment

Study Overview
=================
Brief Summary
-----------------
Evaluation of the ciliary muscle thickness, area, and anterior chamber angle, as well as anterior sclera thickness in subjects, to investigate the relationship between these measurements and corneal biomechanics. Clarify whether aqueous humor displacement, anterior sclera, and ciliary muscles influence the assessment of in vivo corneal biomechanics.

Official Title
-----------------
Correlation Analysis Between In-vivo Corneal Biomechanical Properties and Anterior Segment in Chinese Population

Conditions
-----------------
Ciliary Muscle Thickness, Anterior Sclera Thickness, Corneal Biomechanics, CASIA2

Intervention / Treatment
-----------------
* Other: Pentacam, Corvis ST and Casia2


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Best corrected visual acuity (BCVA) ≥ 20/20; No other eye diseases except myopia and astigmatism; The cornea was transparent, and there was no cloud or pannus; Exclusion Criteria: Corneal disease; Ocular trauma; Previous ocular surgery; Any anterior segment diseases except cataract; Patients were required to stop wearing soft contact lenses for at least 2 weeks and rigid contact lenses for at least 4 weeks before examination; Pregnant and lactating women;
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normal group<br> | Other: Pentacam, Corvis ST and Casia2<br>* scleral and ciliary muscle thickness were obtained by Casia2, biomechanical parameters were obtained by Pentacam and Corvis ST<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| scleral and ciliary muscle thickness | The thickness of scleral and ciliary muscle(Casia2, quantitative data through the utilization of its integrated ruler system) | one year | 
| biomechanical parameters | The biomechanical parameters(Corvis ST, exporting the quality-assured csv files to analysis) | one year |
Umbrella Study for Analysis of Data Related to Patients With Cancer

Study Overview
=================
Brief Summary
-----------------
This study is a multisite, minimal risk, non-interventional study using patient electronic health record data collected as part of standard of care to answer cohort-based research questions and create robust real-world data sets.

Detailed Description
-----------------
One key purpose of the Study is to collect data that may be used for a wide range of scientific questions and real-world insights.

Official Title
-----------------
Umbrella Study for Analysis of Data Related to Patients With Cancer

Conditions
-----------------
Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Subjects must be diagnosed with cancer Medical records available to meet cohort requirements Exclusion Criteria: - None
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with cancer<br>No intervention or sample collection is required on the study. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Provide RWD/E Datasets to Research Collaborators to Support Development | Use data analysis to enable deeper understanding of patient population characteristics and outcomes to more accurately assess clinical trial feasibility and optimize trial design. | 5 years | 
| Provide RWD/E Datasets to Research Collaborators to Support Regulatory | Use data analysis to generate supplemental data for new accelerated approval pathway filings and provide real world control arms where necessary. | 5 years | 
| Provide RWD/E Datasets to Research Collaborators to Support Commercialization | Use data analysis to enable more precise characterization of biomarker testing rates, factors influencing access to testing, and uptake of recently approved therapies to inform commercial strategy for pharmaceutical companies and generate evidence for payors. | 5 years | 
| Provide RWD/E Datasets to Research Collaborators to Support Phase IV Surveillance | Use data analysis to support post approval understanding of longer term side effects that may not be sufficiently detected via randomized clinical trials. | 5 years | 
| Provide RWD/E Datasets to Research Collaborators to Support Real-World Insights | Use data analysis to further understanding of variations in patient care across the US to help ensure patients have access to optimal testing and treatment. | 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Data Analysis, Master Protocol, Oncology, Retrospective
Effect of 3 Week vs 6 Week Orthodontic Appointment Intervals on Teeth Alignment

Study Overview
=================
Brief Summary
-----------------
Effect of 3 week vs 6 week orthodontic appointment intervals on teeth alignment in patients with moderate to severe dental crowding: a randomized clinical trial. There is still inconclusive evidence about the orthodontics treatment duration and interappointment interval.

Detailed Description
-----------------
Patients with moderate to severe crowding will be divided randomly into two groups (Group A and Group B). Group A includes patients with an interval of 3 weeks between their appointments while Group B includes the patients with an interval of 6 weeks between their appointments. To determine the mean changes in the tooth irregularity index of a patient with mild to moderate crowding activated every 3rd week To determine the mean changes in the tooth irregularity index of a patient with mild to moderate crowding activated every 6th week To compare the difference between the two modalities in percentage

Official Title
-----------------
Effect of 3 Week vs 6 Week Orthodontic Appointment Intervals on Teeth Alignment in Patients With Moderate to Severe Dental Crowding: a Randomized Clinical Trial

Conditions
-----------------
Orthodontic Tooth Movement, Tooth Alignment

Intervention / Treatment
-----------------
* Procedure: tooth alignment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients aged 16-30 Little's irregularity index from 5mm to 12mm Healthy periodontium No systemic disease Patients giving consent for inclusion Exclusion Criteria: Little's irregularity index less than 5mm and more than 12mm Blocked out incisors needing push coil Ankylosed teeth Active periodontal disease Systemic bone disease Non-compliant patients Patients with frequent breakages

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 3 week interval<br>3 week orthodontic interappointment interval | Procedure: tooth alignment<br>* Alignment will be assessed by Little's Irregularity Index<br>|
| Experimental: 6 week interval<br>6 week orthodontic interappointment interval | Procedure: tooth alignment<br>* Alignment will be assessed by Little's Irregularity Index<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| alignment efficiency and interappointment interval | Changes in Little's Irregularity Index between arm 1 and arm 2 and comparison of both interventions. | Time frame for measurement of (Little's Irregularity Index) was every 6th week over a period of 6 months, giving a total of 5 measurements |
PHAGEinLYON Clinic Cohort Study: a Descriptive Study of Severe Infections Treated With Phage Therapy at the HCL.

Study Overview
=================
Brief Summary
-----------------
PHAGEinLYON Clinic cohort study is a single site non-interventional retrospective and prospective study, initiated by the Hospices Civils de Lyon. Population targeted are patients with a severe infection treated with bacteriophage in the Hospices civils de Lyon from 2015 to 2033. The primary objective is to describe the severe infections treated with phagotherapy. 250 patients will be included in the study.

Official Title
-----------------
Non Interventional Retrospective and Prospective Single Center Descriptive Study of Severe Infections Treated With Phage Therapy at the Hospices Civils de Lyon (PHAGEinLYON Clinic Cohort Study).

Conditions
-----------------
Severe Infection

Intervention / Treatment
-----------------
* Other: Description of severe infection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient with severe infection treated with bacteriophage in the Hospices Civils de Lyon from 01/01/2015 to 01/01/2033 PHAGEinLYON Clinic cohort study information notice provided to the patient Exclusion Criteria: Opposition of trial participant
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with severe infection.<br>Patients with severe infection treated with bacteriophage in the Hospices Civils de Lyon from 2015 to 2033. | Other: Description of severe infection<br>* Description of severe infections treated with bacteriophage in the Hospices Civils de Lyon from 2015 to 2033.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of each type of severe infection | Rate of each type of severe infection treated with bacteriophage in the Hospices Civils de Lyon from 2015 to 2033. | through study completion (5years) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bacteriophage, severe infection
Re-hospitalisation After Transcatheter Aortic Valve Implantation

Study Overview
=================
Brief Summary
-----------------
The goal of this study is to investigate whether patient-tailored follow-up for patients treated with transcatheter aortic valve implantation (TAVI) can prevent re-hospitalisation and improve quality of life compared with the standard follow-up program. The rationale of this study is the persistently high rate of re-hospitalisation after TAVI, which increases the risk of mortality and diminishes the patient-evaluated quality of life. Our hypothesis is that patient-tailored follow-up for patients treated with TAVI will reduce the rate of re-hospitalisation after the TAVI-procedure and improve quality of life. The primary endpoints are the rate of re-hospitalisation within 90 days of the procedure and quality of life adjusted life years at 90-day follow-up.

Official Title
-----------------
Re-hospitalisation After Transcatheter Aortic Valve Implantation

Conditions
-----------------
Aortic Valve Disease, Aortic Valve Stenosis

Intervention / Treatment
-----------------
* Behavioral: Intensified follow-up


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who underwent technical successful TAVI Residing in Denmark Provided written informed consent Exclusion Criteria: Index admission mortality Index admission conversion to open surgery Age < 18 years Women of childbearing potential, pregnant or nursing

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Standard follow-up<br> | |
| Experimental: Intensified follow-up<br>Early, intensified follow-up after discharge from TAVI-procedure consisting of telephone consults and an additional visit to the outpaitent clinic. | Behavioral: Intensified follow-up<br>* Early, intensified follow-up after discharge from TAVI-procedure.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The rate of all-cause hospitalisations between discharge from the index procedure and 90 days post-TAVI | Primary safety endpoint | 365 days | 
| Quality-of-life adjusted life years at 90 days after the TAVI-procedure | Primary efficacy endpoint | 365 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The risk of all-cause mortality |  | 365 days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Transcatheter Aortic Valve Implantation, Transcatheter Aortic Valve Replacement, Aortic Valve Stenosis
Attitudes and Unmet Needs Among Type 2 Diabetes Patients

Study Overview
=================
Brief Summary
-----------------
The main purpose of this study is to explore experiences and understand the unmet needs of people with Type 2 Diabetes (T2D) among those who are being managed with basal insulin and those who are insulin naïve in order to understand perspectives for a once weekly insulin option; including any potential barriers to being managed with insulin therapy overall. Study participants will be recruited to complete a 15-minute self-administered online survey.

Official Title
-----------------
Attitudes and Unmet Needs Among Type 2 Diabetes Patients

Conditions
-----------------
Type 2 Diabetes

Intervention / Treatment
-----------------
* Other: No treatment given


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Informed consent obtained before any study-related activities (study-related activities are any procedure related to recording of data according to the protocol). Male or female, age above or equal between 18 to 65 years at the time of signing informed consent. Diagnosed with T2D and currently treating T2D with at least one medication Insulin user that is not using insulin pump Lives in a target country Exclusion Criteria: Previous participation in this study. Participation is defined as having given informed consent in this study Mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation Does not meet inclusion criteria requirements

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| People with Type 2 Diabetes<br>Participants are recruited via email through online panel companies | Other: No treatment given<br>* No treatment given<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Current medication burden | Numerical; Multiple select from defined list | At the time of survey response (Day1) | 
| Injection perceptions | Likert scale for measurement of agreement from 1 strongly disagree to 7 strongly agree | At the time of survey response (Day1) | 
| Attitudes regarding T2D overall | Likert scale for measurement of agreement from 1 strongly disagree to 7 strongly agree | At the time of survey response (Day1) | 
| Attitudes regarding T2D treatment | Likert scales for measurement of satisfaction from 1 extremely unsatisfied to 7 extremely satisfied and agreement from 1 strongly disagree to 7 strongly agree | At the time of survey response (Day1) | 
| Attitudes regarding insulin icodec | Likert scales for measurement of likelihood from 0 not at all likely to 10 extremely likely and agreement from 1 strongly disagree to 7 strongly agree; Rank top 3 from defined list | At the time of survey response (Day1) |