Effects of Dexmetomidine and Remifentanil Used for Controlled Hypotension in Septorhinoplasty Surgery on Cardiac Electrophysiology: Prospective Randomized Study

Study Overview
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Brief Summary
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Our aim in this treatment was to reveal the effects of remifentanil and dexmetomidine, which we used to provide controlled hypotension in septorhinoplasty surgery, on cardiac electrophysiology. We planned to compare the patients by recording preoperative and postoperative ECGs. We also planned to record the patients' intraoperative blood pressure, saturation, and pulse rate, rickeragitation scale, and vas score.

Official Title
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Effects of Dexmetomidine and Remifentanil Used for Controlled Hypotension in Septorhinoplasty Surgery on Cardiac Electrophysiology: Prospective Randomized Study

Conditions
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Rhinoplasty Surgery

Intervention / Treatment
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* Drug: Dexmedetomidine
* Drug: Remifentanil


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with an ASA score of I and between the ages of 17-45 years, who were to undergo general anesthesia with sevofulurane were included in the study. Exclusion Criteria: Patients aged <17 and >45 years, patients with liver and/or kidney failure, obese patients (BMI >30), trauma patients, ASA II-III-IV patients, patients with bleeding disorders, those using drugs that may affect the coagulation system, patients with cardiomyopathy, cerebrovascular disease, immobility, and malnutrition were excluded from the study. -

Ages Eligible for Study
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Minimum Age: 17 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Effects of Dexmetomidine<br>Patients in this group will be given dexmedetomidine infusion during the intraoperative period to provide controlled hypotension. | Drug: Dexmedetomidine<br>* After the induction of general anesthesia, one group (Group: 1) will be administered dexmedotomidin infizyon and group (Group :2)remifentanil<br>|
| Active Comparator: Effects of Remifentanil<br>Patients in this group will be given remifentanil infusion during the intraoperative period to provide controlled hypotension. | Drug: Remifentanil<br>* Remifentanil<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| iceb | Qt\Qrs | preoperative and postoperative (immediatly after extubation) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Riker Agitation Scale | 7 -Dangerous Agitation, 6 - Very Agitated, 5 - Agitated, 4 - Calm and Cooperative, 3 - sedated, 2- Very Sedated, 1 -Unarousable | Immediately after extubation | 
| mean arterial pressure | mmHg | when you come to the operating room table after anesthesia induction Intraoperative 30 minutes after extubasion | 
| heart rate | beats\minute | when you come to the operating room table after anesthesia induction Intraoperative 30 minutes after extubasion | 
| Numeric Rating Scale | They will be numbered from 1 to 10. 1 mildest 10 most severe pain | Postoperative 0-2 hours |