Auditory Functions in Patients With Multiple Sclerosis

Study Overview
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Brief Summary
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The study will analyze the auditory functions of patients with Multiple Sclerosis using auditory tests like pure tone auditory test, speech perception test, Auditory Brain Response (ABR) and Distortion Product Otoacustic Emission (DPOAE). CSF will be collected by lumbar puncture and analyzed looking for inflammatory markers. The results of DPOAE and CSF will be correlated to identify statistically significant correlation.

Detailed Description
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Case-Control study Tools for patients' selection and inclusion in the study STEP one Full medical records detailed for neurological diseases Brain and spinal cord MRI performed 12 months (n1) before and most recent one (n2) Lumbar puncture Blood test Questionnaire for screening hearing disorders App for screening hearing loss STEP two Pure Tone Auditory test + Tympanometry and Stapedial Reflex Speech Perception test In case of tinnitus: tinnitus questionnaire and acuphenometry DPOAEs ABR STEP three in case of Hearing impairment - MRI Tractography

Official Title
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Electrophysiological Studies of Auditory Functions and CSF Analyses in Patients With Multiple Sclerosis

Conditions
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Multiple Sclerosis, Hearing Disorders

Intervention / Treatment
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* Diagnostic Test: Auditory test
* Other: CSF sampling


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria age >18 and <50, no history of hearing loss, no psychiatric condition no familial history of otosclerosis/deafness/genetic hearing loss patients with PD and/or MS. Exclusion Criteria Conductive hearing loss stroke < 2 years cardiovascular disease non under control diabetes hypotensive disorders alcohol abuse recreational drug consumption epilepsy

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Healthy patients between 20 and 40 years | Diagnostic Test: Auditory test<br>* The patients will perform: Pure Tone Auditory test + Tympanometry and Stapedial Reflex Speech Perception test In case of tinnitus: tinnitus questionnaire and acuphenometry DPOAEs ABR<br>Other: CSF sampling<br>* Cerebrospinal Fluid will be collected by lumbar puncture and analyzed<br>|
| MS group<br>Patient with Relapsing Remitting MS age between 20 and 40 years | Diagnostic Test: Auditory test<br>* The patients will perform: Pure Tone Auditory test + Tympanometry and Stapedial Reflex Speech Perception test In case of tinnitus: tinnitus questionnaire and acuphenometry DPOAEs ABR<br>Other: CSF sampling<br>* Cerebrospinal Fluid will be collected by lumbar puncture and analyzed<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Auditory functions and correlation with CSF findings | The worsening of the hearing thresholds and DPOAE results will be correlated with the presence of inflammatory elements in the CSF | 12 months |