Identifying Factors Influencing In-Hospital Relapse in Pemphigus Patients

Study Overview
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Brief Summary
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The objective of this retrospective study was to investigate the factors influencing in-hospital relapse during acute episodes of pemphigus, an autoimmune blistering disease characterized by self-antibodies targeting desmogleins. The study included 96 pemphigus patients hospitalized in China between January 2014 and December 2020. The primary questions addressed by the study were: What are the risk factors associated with in-hospital relapse during acute episodes of pemphigus? Participants in the study underwent a retrospective analysis using univariate and multivariate Cox regression analysis to identify and understand the various risk factors contributing to in-hospital relapse. This research aimed to contribute valuable insights into the factors influencing the course of pemphigus, providing crucial information for better management and treatment strategies.

Detailed Description
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This retrospective study conducted in China between January 2014 and December 2020 aimed to comprehensively examine factors influencing in-hospital relapse during acute episodes of pemphigus, an autoimmune blistering disease characterized by self-antibodies targeting desmogleins-essential cell adhesion molecules. The study enrolled 96 pemphigus patients who were hospitalized during acute episodes. Research Questions: Primary Question: What are the identifiable risk factors associated with in-hospital relapse in pemphigus patients during acute episodes? Methods: Study Type: Retrospective Observational Study Participant Population: 96 pemphigus patients hospitalized in China Duration: January 2014 to December 2020 Main Tasks: Data Collection: Retrospective analysis of medical records and clinical data of pemphigus patients during acute hospitalizations. Identification of demographic information, clinical characteristics, and treatment modalities. Risk Factor Determination: Univariate and multivariate Cox regression analysis employed to assess potential risk factors. Variables considered included demographic factors, disease severity, and specific treatment regimens. Outcome Measurement: Identification of in-hospital relapse as the primary outcome. Correlation of relapse occurrence with the identified risk factors. Results: Key Findings: Identification of specific risk factors contributing to in-hospital relapse in pemphigus patients. Quantification of the impact of demographic and clinical variables on relapse probability. Significance: Clinical Implications: Contribution of valuable insights for clinicians in predicting and managing in-hospital relapse in pemphigus patients. Informing treatment strategies based on identified risk factors. Research Contribution: Expansion of understanding regarding the course and management of pemphigus. Providing a foundation for future prospective studies and the development of targeted interventions.

Official Title
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Identifying Factors Influencing In-Hospital Relapse in Pemphigus Patients: A Retrospective Study

Conditions
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Pemphigus Vulgaris

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: inpatients. Pathologic diagnosis of pemphigus. Exclusion Criteria: Patients hospitalized for cyclophosphamide shock therapy only. Patients who did not recover and were discharged due to personal reasons.

Ages Eligible for Study
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Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pemphigus patients in the First Affiliated Hospital of Chongqing Medical University<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| in-hospitalization relapse | the occurrence of in-hospital relapse among pemphigus patients during acute episodes | through hospitalization (Up to 1 month) |