Impact of Frailty and ICU-AW on Post-ICU Fatigue Self-reported

Study Overview
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Brief Summary
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After a prolonged stay in Intensive Care Unit (ICU), fatigue is the most common symptom reported by patients in the Post Intensive Care Syndrome (PICS). Other complications have been described, including ICU-acquired weakness, leading to increased morbidity and mortality after discharge. Actually, risk factors associated with post-ICU fatigue self-reported are not really known.

Detailed Description
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Frailty, defined as a decrease in physiological reserves leading to an alteration in the mechanisms of adaptation to stress, increases the incidence of PICS and could therefore be a cause of post-ICU fatigue self-reported. The aim of this study is to identify a relationship between markers of frailty, ICU-AW, ICU story and the post-ICU fatigue self-reported 6 months discharge in patients with prolonged ICU stays.

Official Title
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Impact of Frailty and ICU-AW on Post-ICU Fatigue Self-reported

Conditions
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Post Intensive Care Syndrome

Intervention / Treatment
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* Other: observational prospective data collection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with a length of stay in intensive care > or equal to 7 days, or mechanical ventilation > or equal to 5 days Exclusion Criteria: Scheduled surgery with admission in ICU Pregnancy Guardianship

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients on etiologies<br>Patients over 18 admitted in ICU for all etiologies with mechanical ventilation over 5 days or length of stay in ICU over 10 days will be included | Other: observational prospective data collection<br>* Collection of data from medical records.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Frailty | Relationship between frailty markers (CFS, IADL, sarcopenia and myosteatosis), ICU-AW, ICU story and post-ICU fatigue self-reported | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fatigue | Prevalence of post-ICU fatigue self-reported 6 months discharge in prospective cohort | 1 year | 
| ICU-acquired weakness and fatigue | Correlation between post-ICU fatigue self-reported and muscular strength assessed by handgrip test | 1 year | 
| Fatigue, quality of life, anxiety and depressive disorder | Correlation between fatigue, quality of life, anxiety and depressive disorder | 1 year | 
| Kinetic of muscle mass loss and post-ICU fatigue self-reported | Correlation between the kinetic of muscle mass loss and post-ICU fatigue self-reported | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Intensive Care Unit, frailty, fatigue, ICU acquired-weakness, FACIT-F, physical activity