Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

Study Overview
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Brief Summary
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This research study aims to develop a brief group-based treatment called Resilience Training for Teens, then to test how well it protects high school students with mild symptoms of depression, anxiety, or having unusual feelings from developing mental illnesses.

Official Title
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Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

Conditions
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Anxiety Disorders, Psychotic Disorders, Depressive Disorder, Psychosocial Functioning

Intervention / Treatment
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* Behavioral: Resilience Training for Teens


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Currently enrolled in 9th through 12th grade and between the ages of 14 and 19 Endorsed at least one psychotic experience Provided contact information Have a parent or legal guardian who is able and willing to provide written informed consent (if under the age of 18) Have a parent or legal guardian who is able and willing to participate in a parent session Competent and willing to provide written informed assent (if under the age of 18) or consent (if age 18 or older) Able to communicate in English Exclusion Criteria: Currently prescribed psychotropic medication (not including medications for attention deficit/hyperactivity disorder), regardless of adherence Currently obtaining psychotherapeutic intervention

Ages Eligible for Study
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Minimum Age: 14 Years
Maximum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Resilience Training for Teens<br>A brief 6-session group-based behavioral intervention for teens at risk of a mental illness. | Behavioral: Resilience Training for Teens<br>* A brief 6-session group-based behavioral intervention for high school aged teenagers at risk of a mental illness.<br>|
| No Intervention: Waitlist<br>A one year waitlist period where participants will not participate in Resilience Training for Teens. Following that one year waitlist period, they can participate in Resilience Training for Teens. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Structured Interview of Psychosis-risk Syndromes (SIPS) | Subclinical psychotic symptoms that represent a risk of transdiagnostic mental illnesses. This semi-structured interview rates psychotic experiences, general symptoms, and functioning. The SIPS interview assesses positive, negative, disorganized, and general symptoms. The range of the Scale of Psychosis-risk Symptoms (SOPS) is 0-6, with a higher score representing more severe symptoms. | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Child Behavior Checklist (CBCL) | Mental health symptoms in the teen rated by both the teen and the parent/guardian consisting of 113 items. The CBCL rates multiple domains across functioning and psychiatric diagnoses. It is scored on a 3-point Likert scale, with higher scores representing more severe symptoms. | 1 year | 
| Global Functioning Social and Role Scales | Social and school/work functioning captured on this scale rated on a 10 point likert scale assessing functional and social functioning separately. Higher ratings represent richer functioning. | 1 year |