Duration of Silicone Oil Tamponade on Foveal and Parafoveal Thickness in Rhegmatogenous Retinal Detachment

Study Overview
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Brief Summary
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Our study observes and analyses the influence of the duration of tamponade with silicone oil on the foveal and parafoveal thickness.

Detailed Description
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Retrospective Cohort study Retrospective review of records of eyes with Rhegmatogenous Retinal Detachment (RRD, for whom pars plana vitrectomy and silicone oil had been performed, in the period between January 2019 and December 2021. After checking inclusion and exclusion criteria; we will enroll all the cases. We shall observe the duration of silicone oil tamponade, and then divide the cases; accordingly; into 2 groups (Cohort). Group A: 3 months SO Tamponade Group B: 6 months SO Tamponade

Official Title
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Impact of Duration of Silicone Oil Tamponade on Foveal and Parafoveal Thickness in Rhegmatogenous Retinal Detachment: A Retrospective Cohort Study

Conditions
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Retinal Detachment

Intervention / Treatment
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* Other: Silicone oil Tamponade for Retinal Detachment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Silicone oil (SO) tamponade ( up to 6 months) Attached retina under SO Attached retina 3 months after Silicone oil Removal (SOR) Normal fellow eye ( no retinal detachment or macular disease) OCT scan performed for the operated eyes (before SOR, and 3 months after SOR), and for the fellow eye (at any time during the study) Exclusion Criteria: • Rhegmatogenous Retinal Detachment (RRD) with other tamponades ( e.g.: Gas, Densiron) SO tamponade less than 3 months, or more than 6 months Recurrent RD under SO Recurrent RD within 3 months after SOR One eyed Vitrectomized fellow eye Retinal detachment, or macular disease in the fellow eye. Posterior staphyloma Anisometropia (history, refraction if possible, spectacles prescription) Absence of any of the OCT scans performed for the operated eyes (before SOR, and 3 months after SOR), and for the fellow eye (at any time during the study)
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group A<br>Group A: 3 months SO Tamponade | Other: Silicone oil Tamponade for Retinal Detachment<br>* eyes with Rhegmatogenous Retinal Detachment (RRD, for whom pars plana vitrectomy and silicone oil had been performed<br>|
| Group B<br>Group B: 6 months SO Tamponade | Other: Silicone oil Tamponade for Retinal Detachment<br>* eyes with Rhegmatogenous Retinal Detachment (RRD, for whom pars plana vitrectomy and silicone oil had been performed<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in CFT just before SOR (central foveal thickness) | Change in CFT just before SOR (from baseline fellow eye) (microns, %) (each group) | baseline to time just before silicone oil removal | 
| Change in PFT just before SOR (Parafoveal thickness) | Change in PFT just before SOR (from baseline fellow eye) (microns, %) (each group) | baseline to time just before silicone oil removal | 
| • Change in CFT after SOR | • Change in CFT after SOR (from baseline fellow eye) (microns, %) (each group) | from baseline fellow eye to 1 month after silicone oil removal | 
| • Change in PFT after SOR | • Change in PFT after SOR (from baseline fellow eye) (microns, %) (each group) | from baseline fellow eye to 1 month after silicone oil removal | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| • Relative Risk of severe CFT Thinning before SOR (between group A and B) | • Relative Risk of severe CFT Thinning before SOR (between group A and B) | baseline to time just before silicone oil removal | 
| • Relative Risk of severe PFT Thinning before SOR (between group A and B | • Relative Risk of severe PFT Thinning before SOR (between group A and B | baseline to time just before silicone oil removal | 
| • Relative Risk of severe CFT Thinning after SOR (between group A and B) | • Relative Risk of severe CFT Thinning after SOR (between group A and B) | from baseline fellow eye to 1 month after silicone oil removal | 
| • Relative Risk of severe PFT Thinning after SOR (between group A and B) | • Relative Risk of severe PFT Thinning after SOR (between group A and B) | from baseline fellow eye to 1 month after silicone oil removal |