Acute Liver Injury in Patients With Pneumonia

Study Overview
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Brief Summary
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Acute liver injury (ALI) is defined as an acute derangement in liver function tests associated with liver-related coagulopathy, in the absence of underlying chronic liver disease. A subset progress to acute liver failure ,Acute liver failure represent a more severe liver injury results in hepatic encephalopathy

Detailed Description
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Acute liver injury is associated with a spectrum of haemostatic changes, including thrombocytopenia and reduced platelet function, reduced plasma levels of many coagulation factors such as factor (F)VII and increased levels of FVIII . Pneumonia is an acute inflammation of the lower respiratory tract. Lower respiratory tract infection is a major cause of mortality worldwide .Pneumonia is most common at the extremes of life. In adults, pneumonia can be broadly classified, on the basis of chest radiographic appearance, into lobar pneumonia, bronchopneumonia and pneumonia producing an interstitial pattern. There is lack of data regarding outcome and hospital stay in patients with pneumonia who develop acute liver injury.

Official Title
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Acute Liver Injury in Patients With Pneumonia and Its Impact on Hospital Stay and Outcome

Conditions
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Acute Liver Injury, Pneumonia

Intervention / Treatment
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* Other: Acute Liver Injury


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with pneumonia that developed Acute Liver Injury Covid 19 pneumonia Patients With acute liver injury only. Exclusion Criteria: Cancer Immunocompromised patients i.e HIV patients and patients who take immunosuppressive medications. Patients who younger than 18 yrs old pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 68 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group A<br>About 88 patients having pneumonia and developed acute liver injury That need observation of the outcome and hospital stay to evaluate acute liver injury impact | Other: Acute Liver Injury<br>* To evaluate the impact of acute liver injury in patients with pneumonia on hospital stay and outcome.<br>|
| Group B<br>About 88 patients having pneumonia but did not develop acute liver injury that need observation of the outcome and hospital stay | Other: Acute Liver Injury<br>* To evaluate the impact of acute liver injury in patients with pneumonia on hospital stay and outcome.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Impact of Acute liver injury due to Pneumonia | Analysis the impact of acute liver injury related to patients with pneumonia on hospital stay (measured by days spent in the hospital). | From Hospital admission date to Two Months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patients with Pneumonia only | To evaluate the Patients with Pneumonia either developed acute liver injury or not, On Hospital Stay | From Hospital admission date to Two Months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute Liver Injury, pneumonia, Covid19