Narcolepsy Nightmare Study

Study Overview
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Brief Summary
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The goal of this clinical trial is to test two behavioral treatments for nightmares in adults with narcolepsy. The main questions it aims to answer are: Is imagery rehearsal therapy (IRT) effective for narcolepsy-related nightmares? Does adding targeted dream control (TDC) to IRT make it more effective? Participants will be randomized to one of two treatment groups and will be asked to: Complete a daily log of sleep symptoms for up to 13 weeks. Attend 7 sessions of treatment. Complete questionnaires before and after treatment. Go to the research lab in Evanston, IL to complete a sleep study during a daytime nap (Chicago area residents only).

Official Title
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Behavioral Treatment of Narcolepsy-Related Nightmares

Conditions
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Narcolepsy, Narcolepsy Type 1, Narcolepsy With Cataplexy, Narcolepsy Type 2, Narcolepsy Without Cataplexy

Intervention / Treatment
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* Behavioral: Imagery rehearsal therapy
* Behavioral: Targeted dream control


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria (all participants): Diagnosis of narcolepsy Age 18 or older Speak English Live in the United States Receiving standard medical care for narcolepsy Sleep and psychiatric medications stable for at least 3 months Nightmare frequency of ≥3 times per week Nightmare Disorder Index score indicates probable nightmare disorder Inclusion Criteria (Chicago area participants): Able to attend a study appointment in Evanston, IL Able and willing to not take wake-promoting medications on day of lab visit Exclusion Criteria: History of a neurological disorder that might alter EEG Currently engaged in sleep- or trauma-focused psychotherapy Previous behavioral treatment for nightmares Medical, psychiatric, or cognitive condition which would interfere with ability to engage in the treatment Untreated sleep apnea (AHI ≥ 5)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Imagery rehearsal therapy (IRT)<br>Participants randomized to this group will receive 7 sessions of IRT. | Behavioral: Imagery rehearsal therapy<br>* Therapy to reduce nightmares, delivered via videoconference sessions<br>* Other names: IRT;|
| Experimental: Imagery rehearsal therapy and targeted dream control (IRT+TDC)<br>Participants randomized to this group will receive 7 sessions of IRT+TDC. | Behavioral: Imagery rehearsal therapy<br>* Therapy to reduce nightmares, delivered via videoconference sessions<br>* Other names: IRT;Behavioral: Targeted dream control<br>* Therapy to reduce nightmares, delivered in videoconference sessions and lab session. Lab session will involve a sleep study during a daytime nap.<br>* Other names: TDC;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Daily diary | Nightmare severity/frequency | Duration of study (11-13 weeks) |