Uterine Peristalsis in IVF

Study Overview
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Brief Summary
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An observational prospective cohort study to evaluate the effect of uterine peristalsis at the time of embryo transfer on IVF clinical outcomes performed in Women's Health hospital, Assiut University, Egypt. Women performing fresh or frozen embryo transfer who do not have any uterine abnormalities will be included in the study

Official Title
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Effect of Uterine Peristalsis at the Time of Embryo Transfer on the Outcomes of IVF Cycles: a Prospective Cohort Study

Conditions
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Infertility, Female

Intervention / Treatment
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* Other: uterine peristalsis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • Women undergoing embryo transfer during IVF cycles. Age: between 20 and 40 years. Have at least 1 good quality embryo at the time of transfer Fresh or frozen-thawed cycles. Any stimulation protocol in fresh cycles, or any endometrial preparation protocol for frozen-thawed cycles Exclusion Criteria: • Women refusing to participate in clinical research. Any uncorrected uterine abnormality, such as septum, myoma, adenomyosis, or polyp Hydrosalpinx without prior disconnection or excision

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: uterine peristalsis|Transabdominal us followed by Transvaginal ultrasonography scans (Sono Ace R5 ) of uterine peristalsis will performed on the day of embryo transfer while the patient lying relaxed in lithotomy position. The probe will be introduced into the vagina as gently as possible to avoid stimulating the cervix. After scanning the mid-sagittal plane of the uterus, the probe will be fixed as steady as possible while a 3 min video of uterine peristalsis will be recorded simultaneously. The records will be analyzed at 4X regular speed using a Video player application by two independent experienced observers. The uterine peristaltic wave frequency will be the mean of the results from each observer.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical pregnancy | The presence of intrauterine gestational sac and fetal pole with positive cardiac pulsation by transvaginal ultrasound | 2 weeks after a positive pregnancy test | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Biochemical pregnancy | a positive serum human chorionic gonadotropin | 2 weeks after embryo transfer | 
| Miscarriage | Pregnancy loss either loss of cardiac pulsation by ultrasound, or spontaneous loss of pregnancy vaginally | From 6 weeks of gestation until 28 weeks of gestation | 
| Ectopic pregnancy | Pregnancy outside the uterine cavity | the site of the gestational sac will be assessed 2 weeks after embryo transfer | 
| Ongoing pregnancy | The presence of a viable pregnancy after 12 weeks of gestation | After 12 weeks of gestation until delivery | 
| Live birth | Delivery of a living foetus after the age of viability | From 28 weeks of gestation until delivery |