Effect of Terlipressin on the Incidence of Early Postoperative Acute Kidney Injury in Liver Transplantation Patients

Study Overview
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Brief Summary
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The goal of this clinical trial is to evaluate the effect of intraoperative terlipressin on the incidence of early postoperative acute kidney injury in deceased doner liver transplantation. Patients were randomly divided into experimental group and control group by numerical randomization table. The experimental group was injected with terlipressin perioperative and the control group was injected with placebo

Detailed Description
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acute kidney injury is a relatively common complication in patients with liver transplantation. Most centers have established prediction models for acute kidney injury after liver transplantation, but the incidence cannot be reduced through perioperative anesthesia management. As an vasopressin receptor agonist, terlipressin can increase blood pressure and improve kidney perfusion at the same time, and perioperative application may reduce the incidence of postoperative acute kidney injury

Official Title
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Effect of Intraoperative Terlipressin on the Incidence of Early Postoperative Acute Kidney Injury in Liver Transplantation Patients: a Randomized, Double-blind, Placebo-controlled Study

Conditions
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Acute Kidney Injury, Liver Transplant; Complications

Intervention / Treatment
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* Drug: Terlipressin
* Drug: normal saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1) Patients who plan to undergo liver transplantation in our hospital 2) Patients or family members sign informed consent Exclusion Criteria: Patients <18 years old;② Patients undergoing autologous liver transplantation or combined transplantation;③ Patients with lower extremity artery stenosis;(4) Patients with severe heart disease、lung disease、kidney disease;⑤ Patients with severe lung disease;⑥ Patients who used renal replacement therapy before surgery;⑦ the depth of one kidney from the body surface is greater than 4cm;⑧ Patients treated with terlipressin within 2 weeks before surgery⑨ Patients allergic to terlipressin.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: experimental group<br>Continuous terlipressin infusion，Use a syringe to dilute to 50ml Infusion speed is 2ug/kg*h, From the beginning to the end of the surgery. | Drug: Terlipressin<br>* The medication is dispensed by the nursing staff before surgery and given to the anesthesiologist before the procedure begins<br>* Other names: Glypressin;|
| Placebo Comparator: control group<br>Continuous normal saline infusion，Use a syringe to draw 50ml Infusion speed is 4ml/h, From the beginning to the end of the surgery. | Drug: normal saline<br>* The medication is dispensed by the nursing staff before surgery and given to the anesthesiologist before the procedure begins<br>* Other names: normal sodium;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of acute kidney injury after liver transplantation | acute kidney injury diagnostic criteria (2012 edition) | in 7 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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terlipressin, Liver Transplant