Number of Previous Cesarean Sections on the Results of Angiogenic Factors.

Study Overview
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Brief Summary
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Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries. The only cure for THE is termination of pregnancy, which ends up being a decision in which gestational age and maternal risks must be balanced. Angiogenic factors have come to occupy an indispensable place in the arsenal of tools that can be used to separate the patient with a high likelihood of complications from those in whom prolongation of pregnancy could represent an important neonatal benefit. Although the usefulness of angiogenic factors in these scenarios is known, little is known about the effects that other conditions might have on their serum levels, mainly those that have an effect on trophoblastic invasion, the process that initiates implantation of the pregnancy in the endometrium. The purpose of the present study is to assess the effect that a history of uterine surgery, such as caesarean section, might have on angiogenic factor scores in subjects with no history of a hypertensive disorder of pregnancy.

Official Title
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Effect of Number of Previous Cesarean Sections on the Results of Angiogenic Factors. A Descriptive, Prospective Study.

Conditions
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Cesarean Section

Intervention / Treatment
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* Diagnostic Test: sFlt-1/PGIF


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 36 weeks of gestation or more Singleton pregnancy Previous cesarean section (case) Exclusion Criteria: Vasculitis Twin pregnancy Chronic endometritis Smoking Lupus Renal failure Liver disease Thrombocytopenia

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Previous Cesarean Section<br>Subjects with one or more previous cesarean sections | Diagnostic Test: sFlt-1/PGIF<br>* Index of sFlt-1/PGIF<br>|
| No Cesarean<br>Subjects scheduled for an elective or urgent cesarean, but no history of previous cesarean section | Diagnostic Test: sFlt-1/PGIF<br>* Index of sFlt-1/PGIF<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Index sFlt-1/PIGF | Angiogenic factors, normal value. | From the moment of randomization up until delivery. Between 24-48 hours. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression to preeclampsia | Number of subjects that develop a preeclampsia | Up until discharge. On average, 7 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cesarean section, Angiogenic factors, Preeclampsia