Effect of Covid-19 on Hypertension

Study Overview
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Brief Summary
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In this single center , retrospective study, 5355 covid patient were selected from 2020 to 2022, with recorded blood pressure before covid and recording after covid. Blood pressure before and after covid were compared, by pair T test.

Detailed Description
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design and participants This single-center retrospective cohort study was conducted at an outpatient cardiology clinic in Shiraz, Iran, between February 15, 2020, and December 28, 2022. We evaluated patients with a confirmed diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by RNA reverse-transcriptase polymerase-chain-reaction assays from nasopharyngeal or oropharyngeal swab specimens according to World Health Organization guidelines (12). Two physicians (PA, MY) reviewed the patients' electronic medical records, including demographics, comorbidities, vital signs, treatments, and outcomes. Ambiguities were resolved by a third author (MM). The current study included all COVID-19 patients who had at least one documented blood pressure measurement in the three months preceding infection and one documented measurement one to three months following recovery. The following patients were excluded: those under 18, with hospital admission due to COVID-19, who received corticosteroid therapy, those with a history of systemic inflammatory disease, kidney or liver, immunocompromised patients, and those who switched their antihypertensive regimen during the study. Finally, 5,355 eligible patients were investigated . The primary outcome was to assess BP variation following infection (particularly a prolonged rise in BP) among non-hospitalized COVID-19 patients. The secondary outcome was to identify the predictor factors of BP variation. The present study was approved by the Ethics Committee of Shiraz University of Medical Sciences under code IR.SUMS.MED.REC.1401.465 , and the need for informed consent was waived due to the study's retrospective nature and the absence of patient identifiers in the presented data.

Official Title
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The Long-term Impact of COVID-19 on Blood Pressure: A Retrospective Cohort Study

Conditions
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COVID-19, Hypertension

Intervention / Treatment
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* Diagnostic Test: blood pressure measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All COVID-19 patients who had at least one documented blood pressure measurement in the three months preceding infection and one documented measurement one to three months following recovery Exclusion Criteria: Age under 18 Hospital admission due to COVID-19 Corticosteroid therapy, History of systemic inflammatory disease kidney disease liver disease Immunocompromised patients

Ages Eligible for Study
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Minimum Age: 39 Years
Maximum Age: 71 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| hypertensive<br>Covid patients with exacerbated hypertension or new hypertension post covid | Diagnostic Test: blood pressure measurement<br>* Taking blood pressure with automated arm sphygmomanometer and pressure higher than 140/90 was considered abnormal<br>|
| non hypertensive<br>Covid patients with no change in blood pressure pre and post covid | Diagnostic Test: blood pressure measurement<br>* Taking blood pressure with automated arm sphygmomanometer and pressure higher than 140/90 was considered abnormal<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| change of blood pressure | any change in blood pressure level before and after covid infection | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| predictors of changes in blood pressure | history of any risk factor for cardiac disease, age, sex, | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hypertension, blood pressure, covid-19