Prevalence and Impact of Diabetes Mellitus in Hospitalized COVID-19 Patients in a Tunisian Center

Study Overview
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Brief Summary
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Objective: The objective of this study was to evaluate the prevalence and impact of diabetes mellitus on the severity and mortality of COVID-19. Methods: Data of laboratory-confirmed hospitalized patients at the COVID-19 unit of Ibn El Jazzar University Hospital in Kairouan between September 2020 and August 2021 were analysed, in a cross-sectional study. The population was classified into two groups (COVID-19 patients with versus without diabetes). Primary outcomes were the overall length of hospital stay, the admission to the intensive care unit (ICU), and death.

Detailed Description
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The outbreak of the coronavirus disease 2019 (Covid-19) has become an evolving worldwide health crisis. With the rising prevalence of diabetes mellitus has come an increasing awareness of their impacts on infectious diseases, and the risk for post-infection complications and mortality from critical infections. Objective: The objective of this study was to evaluate the prevalence and impact of diabetes mellitus on the severity and mortality of COVID-19. Methods: Data of laboratory-confirmed hospitalized patients at the COVID-19 unit of Ibn El Jazzar University Hospital in Kairouan between September 2020 and August 2021 were analysed, in a cross-sectional study. The population was classified into two groups (COVID-19 patients with versus without diabetes). Primary outcomes were the overall length of hospital stay, the admission to the intensive care unit (ICU), and death. Association between diabetes and death was assessed in a Cox proportional hazards model.

Official Title
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Prevalence and Impact of Diabetes Mellitus in Hospitalized COVID-19 Patients in a Tunisian Center: a Cross Sectional Study

Conditions
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Prevalence, Diabetes Mellitus, Impaction, COVID-19

Intervention / Treatment
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* Other: comparison of outcomes/exposure


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Confirmed cases indicated the patients whose real-time reverse transcriptase-polymerase chain reaction (RT-PCR) analysis results for nasal swab specimens were positive. Exclusion Criteria: the investigators didn't included patients who were suspected cases, and whose the result of PCR test was negative ; Covid-19 patients admitted in other departments (Cardiology, pediatrics, obstetrics, intensive care unit, medicine, surgery department…) ; and patients with missing medical records. -

Ages Eligible for Study
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Minimum Age: 15 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| diabetic patients with COVID-19<br>patients hospitalized for COVID-19 and were diabetic | Other: comparison of outcomes/exposure<br>* analysing if diabetes mellitus have an impact on the primary outcomes: hospital stay, admission to the ICU, death.<br>|
| Non-diabetic patients with COVID-19<br>patients hospitalized for COVID-19 and were not diabetic | Other: comparison of outcomes/exposure<br>* analysing if diabetes mellitus have an impact on the primary outcomes: hospital stay, admission to the ICU, death.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Admission to Intensive Care Units | patients who were transferred to ICU | 7 days | 
| death | patients who were dead | 7 days | 
| overall length of hospital stay | length of hospital stay from admission to discharge (or transfer or death) | 7 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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SARS-CoV2, diabetes mellitus, death, complications, COVID-19, Intensive Care Units, Tunisia