Endovascular Treatment of Wide Neck Saccular Cerebral Aneurysms

Study Overview
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Brief Summary
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Intracranial aneurysm (IA) is a cerebrovascular disorder in which the weakness of a cerebral artery wall causes a localized dilation of the blood vessel. Intracranial aneurysm can develop and rupture, and about 85% of spontaneous subarachnoid hemorrhage (SAH) cases are caused by the rupture of Intracerebral aneurysm. Two treatments are available globally: microsurgical clipping and endovascular treatment. Endovascular treatment of Intracerebral aneurysms using detachable platinum coils ( was introduced in 1990 by Guido Guglielmi, an Italian neurosurgeon ) of different shapes and sizes are deposited into the aneurysm through a microcatheter, which reduces the blood flow and induces thrombus formation . Wide neck aneurysm defined by neck diameter greater than 4 mm or dome-to-neck ratio less than 2 Despite advances in endovascular techniques , the treatment of wide-necked aneurysms remains problematic . Endovascular treatment of intracranial aneurysms is associated with lower morbidity and mortality rates and faster recovery compared with traditional microsurgical clipping. In wide-necked Intracerebral aneurysms, complete coil embolization is often technically difficult owing to the risks of distal coil migration or coil impingement on the parent vessel . Complete coil embolization using a single microcatheter without a supporting device in cases of wide-necked Intracerebral aneurysm is technically difficult. Total occlusion rates have increased recently as a result of the advancement of supporting devices These may include balloon remodeling, use of three-dimensional (3D) coils (Russian Doll Technique), combined use of stents and coils (Stent assisted coiling), flow diverters, use of intrasaccular flow disruption (like WEB), Double catheter Technique or combined extra- and intrasaccular devices.

Official Title
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Endovascular Treatment of Wide Neck Saccular Cerebral Aneurysms

Conditions
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Wide Neck Saccular Cerebral Aneurysms

Intervention / Treatment
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* Procedure: Endovascular procedure of treatment of wide neck saccular cerebral aneurysm


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients of spontaneous subarachnoid haemorrhage due to ruptured wide neck saccular cerebral aneurysms unruptured Denovo wide neck saccular cerebral aneurysms Exclusion Criteria: other forms of cerebral aneurysms rather than saccular type : fusiform and dissecting aneurysms complex aneurysms : giant and thrombosed aneyrsms any spontaneous subarachnoid haemorrhage with world fedriation of neurosurgery societies (WFNS) Grade 4&5 Any patient unfit for general anesethia or has serious renal impairment
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Wide neck saccular cerebral aneurysms patients<br> | Procedure: Endovascular procedure of treatment of wide neck saccular cerebral aneurysm<br>* Endovascular different modalities for occlusion of wide neck saccular cerebral aneurysms include stent assisted coiling or balloon assisted coiling or flow diverter or 3D coiling<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| efficacy of procedure | degree of aneurysm occlusion classifeid by Raymond Roy classification | 1 year |