Calf Circumference Versus X-ray Absorptiometry in the Diagnosis of Sarcopenia in Elderly Hospitalized Patients

Study Overview
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Brief Summary
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This is a prospective single-center study to evaluate a diagnostic method. The main objective of the study is to evaluate the performance of calf circumference as a diagnostic method for sarcopenia in hospitalized elderly people, compared to a gold standard method which is X-ray absorptiometry. The study population are hospitalizing participants aged 75 years and older with an indication to search for sarcopenia.

Detailed Description
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Sarcopenia is a loss of muscle mass associated with a loss of muscle strength. Sarcopenia is associated with an increase of mortality, risk of falling and hospitalization. The gold standard for assessing loss of muscle mass is X-ray absorptiometry. However, this exam is not systematically performed. The calf circumference (cutoff less than 31 centimeters) is preferentially used. However, this cutoff was defined from a population of women with a mean age of 80 years and a unfrail phenotypic profile that does not allow this result to be applied to elderly hospitalized patients. The main objective of this study is to evaluate the performance of calf circumference as a diagnostic method for sarcopenia in hospitalized elderly people, compared to a gold standard method which is X-ray absorptiometry. This is a single-center prospective study to evaluate a diagnostic method. The participants in the study will be hospitalized patients aged 75 years and over, with an indication to search for sarcopenia in the context of screening for protein-energy undernutrition under the recommendations of the French National Authority for Health. Participants will be included after being informed about the protocol and after obtaining their free and informed oral consent. Measurement of calf circumference will be performed before absorptiometry, the results of which will be analyzed in a blinded. The number of subjects to be included with a expected prevalence of 75%, specificity of 95% and an accuracy of 2% is 298 participants according to the literature. A sensitivity and specificity analysis will be performed using the ROC curve. A linear regression analysis will be performed with a significance threshold for the alpha risk of 5%.

Official Title
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Evaluation of a Diagnostic Method: Calf Circumference Versus X-ray Absorptiometry in the Diagnosis of Sarcopenia in Elderly Hospitalized Participants

Conditions
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Sarcopenia

Intervention / Treatment
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* Radiation: Dual-energy X-ray absorptiometry


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age greater than or equal to 75 years Hospitalization in a medical department or in the follow-up care or rehabilitation department of the Hospital Center of Orléans Presence of an etiological criterion of undernutrition Presence of a decrease in muscle strength Exclusion Criteria: Presence of one of two phenotypic criteria for undernutrition other than sarcopenia, which are body mass index less than 22 kilogram per square meter and weight loss (≥ 5 percent over 1 month or ≥ 10 percent over 6 months or ≥10 percent compared with usual weight before the disease). Refusal to participate in the study Patient under legal protection Impossible to perform X-ray absorptiometry (behavioral problems, functional constraints to climb on the DXA machine) Person not affiliated to a social security system

Ages Eligible for Study
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Minimum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Interventional Model Description: This is a prospective single-center evaluation of a diagnostic method
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: X-ray<br>Whole body x-ray absorptiometry for measurement of appendicular muscle mass in kilograms. Only one measurement per participant. | Radiation: Dual-energy X-ray absorptiometry<br>* Whole body x-ray absorptiometry<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of muscle mass using calf circumference | Measurement with a tape measure (in centimetres) of the maximum circumference of the calf | Day 2 | 
| Measurement of muscle mass using X-ray absorptiometry | Measurement of appendicular mass by X-ray absorptiometry in kilograms | Day 2 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Arm circumference | Measurement with a tape measure (in centimetres) of the maximum circumference of the arm | Day 0 | 
| Circumference of the thigh | Measurement with a tape measure (in centimetres) of the maximum circumference of the thigh | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sarcopenia, Absorptiometry, Photon