Risk Markers of Arterial Aging. The Paris Prospective Study III-2

Study Overview
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Brief Summary
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The main objectives of PPS3-2 are (i) to describe the dynamics of vascular aging and baroreflex sensitivity 12 to 16 years a part, (ii) to identify their determinants, and (iii) to quantify the subsequent risk of cardiovascular diseases.

Detailed Description
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Since May 2008, PPS3 is being following the CVD morbidity of 10157 healthy volunteers aged 50-75 years at baseline. In PPS3-2, we plan to re-invite survivors and volunteers of PPS3 to undergo a second physical examination. In particular, they will undergo a second high-precision carotid echotracking to measure vascular aging parameters and baroreflex sensitivity, permitting to study their respective dynamics. They will also underwent for the first time ultra fast echo of the radial artery to measure vascular aging parameters of the medium-sized arteries. According to fundings, blood samples will be taken and stored at -80°C in the whole population or in a subsample.

Official Title
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Risk Markers of Arterial Aging and Subsequent Risk of Cardiovascular Diseases and Beyond. The Paris Prospective Study III-2

Conditions
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Arterial Stiffness

Intervention / Treatment
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* Other: high-precision carotid echo-tracking


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Being enrolled in PPS3 and having signed an informed consent for PPS3-2 Exclusion Criteria: Institutionalized participants Participants under guardianship Participants under judicial safeguard measure

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Level of vascular aging<br>community-based prospective longitudinal cohort | Other: high-precision carotid echo-tracking<br>* evaluation of vascular aging parameters and baroreflex sensitivity<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| carotid diameter | high precision carotid echo tracking diameter in mm | by 2027 | 
| intima media thickness | high precision echo tracking intima media thickness of the common carotid artery in mm | by 2027 | 
| carotid plaques | high precision carotid echo tracking carotid plaques | by 2027 | 
| wall cross sectional area | high precision carotid echo tracking carotid wall cross sectional area, mm2 | by 2027 | 
| distensibility coefficient | high precision carotid echo tracking distensibility coefficient in 10-3/kPa | by 2027 | 
| elastic modulus | high precision carotid echo tracking Young's elastic modulus, 10-3*kPa | by 2027 | 
| pulse wave velocity | high precision carotid echotracking pulse wave velocity, m/s | by 2027 | 
| carotid wall stress | high precision carotid echotracking circumferential wall stress in kPa | by 2027 | 
| stiffness | high precision carotid echotracking Beta stiffness index | by 2027 | 
| pulse pressure | high precision carotid echotracking pulse pressure in mmHg | by 2027 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| brachial artery diameter | ultra high frequency ultrasound radial artery diameter in mm | by 2027 | 
| thickness of the intima media of the radial artery | ultra high frequency ultrasound radial artery intima media thickness in mm | by 2027 | 
| arterial plaques | ultra high frequency ultrasound radial artery plaques | by 2027 | 
| wall cross sectional area of the radial artery | ultra high frequency ultrasound radial artery wall cross sectional area, mm2 | by 2027 | 
| distensibility of the radial artery | ultra high frequency ultrasound radial artery distensibility coefficient in 10-3/kPa | by 2027 | 
| elastic modulus of the radial artery | ultra high frequency ultrasound radial artery Young's elastic modulus, 10-3*kPa | by 2027 | 
| pulse wave velocity of the radial artery | ultra high frequency ultrasound radial artery Pulse wave velocity, m/s | by 2027 | 
| stiffness index of the radial artery | ultra high frequency ultrasound radial artery Beta stiffness index | by 2027 | 
| wall stress of the radial artery | ultra high frequency ultrasound radial artery Circumferential wall stress, kPa | by 2027 | 
| pulse pressure of the radial artery | ultra high frequency ultrasound radial artery Pulse Pressure, mmHg | by 2027 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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risk factors, cohort, cardiovascular diseases