Radiographic Prediction of the Nerve Origin of Neck Peripheral Nerve Sheath Tumors

Study Overview
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Brief Summary
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Postoperative nerve palsy is a major complication following resection of neck peripheral nerve sheath tumors. This study is a retrospective cohort aimed to predict the nerve origin of neck peripheral nerve sheath tumors. Accurate preoperative identification of the nerve origin can improve surgical outcomes and patient counseling

Detailed Description
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Postoperative nerve palsy is a major complication following resection of neck peripheral nerve sheath tumors (PNSTs). Accurate preoperative identification of the nerve origin (NO) can improve surgical outcomes and patient counseling. This study aims to predict the NO of neck PNSTs with radiographic analysis. This study is a retrospective cohort analysis. Radiographic parameters will be reviewed and the sensitivity, specificity, accuracy of NO prediction will be evaluated.

Official Title
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Radiographic Prediction of the Nerve Origin of Neck Peripheral Nerve Sheath Tumors: Retrospective Cohort Study

Conditions
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Peripheral Nerve Sheath Tumors, Schwannoma of Neck

Intervention / Treatment
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* Procedure: Excision


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with clinical diagnosis of neck peripheral nerve sheath tumors. Patients received surgery January 2008 and December 2022. The nerve origin of peripheral nerve sheath tumor must be intraoperatively confirmed. Exclusion Criteria: Previous anterior neck surgery. Malignant disease. Prior neck radiation. Undetermined intraoperative nerve origin.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Vagus nerve tumor group<br>patients with neck peripheral nerve sheath tumors originating from the vagus nerve | Procedure: Excision<br>* All patients underwent surgery under general anesthesia and intraoperative neuromonitoring according to the preoperatively predicted NO. Using an anterior cervical approach, the tumor was delineated after identifying the relationships among the great vessels, nerves, and tumors. The NO was confirmed intraoperatively. Sharp dissection was performed meticulously to enucleate the tumor from the NO to preserve most nerve fibers.<br>|
| Sympathetic nerve tumor group<br>patients with neck peripheral nerve sheath tumors originating from the sympathetic nerve | Procedure: Excision<br>* All patients underwent surgery under general anesthesia and intraoperative neuromonitoring according to the preoperatively predicted NO. Using an anterior cervical approach, the tumor was delineated after identifying the relationships among the great vessels, nerves, and tumors. The NO was confirmed intraoperatively. Sharp dissection was performed meticulously to enucleate the tumor from the NO to preserve most nerve fibers.<br>|
| Cervical spinal nerve tumor group<br>patients with neck peripheral nerve sheath tumors originating from the cervical spinal nerve | Procedure: Excision<br>* All patients underwent surgery under general anesthesia and intraoperative neuromonitoring according to the preoperatively predicted NO. Using an anterior cervical approach, the tumor was delineated after identifying the relationships among the great vessels, nerves, and tumors. The NO was confirmed intraoperatively. Sharp dissection was performed meticulously to enucleate the tumor from the NO to preserve most nerve fibers.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nerve origin | intraoperative identification of the nerve origin of the tumor | within 1 month |