Assessment of Body Composition and Physical Function

Study Overview
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Brief Summary
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Sarcopenia, which is the loss of muscle mass and strength or physical function, naturally occurs in aging. In sarcopenic obesity, growth of muscle mass and increments in strength do not parallel weight gain, and places older adults at increased risk of falls, fractures, physical disability, frailty, and mortality from too low muscle strength relative to body size. The goal of the study is to assess body composition and physical function in older adults with obesity.

Detailed Description
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This is a cross-sectional study in 40 adults aged 60 to 80 years with obesity. Body composition, physical function, and insulin resistance will be measured. Subjects who satisfy the eligibility criteria and sign the informed consent will be enrolled. Subjects will complete an assessment of body composition by bioelectrical impedance analysis and tests of physical performance. Blood will be drawn for measurement of fasting glucose and insulin.

Official Title
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Assessment of Body Composition and Physical Function in Older Adults With Obesity

Conditions
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Body Composition, Physical Function

Intervention / Treatment
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* Other: Body Composition Assessment
* Other: Modified Physical Performance Test
* Other: Hand grip strength
* Other: 6-minute walk test
* Procedure: Measurement of blood glucose and insulin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Body mass index > 30kg/m2 Age 60 - 80 years Exclusion Criteria: self-reported history of diabetes, or cancer or significant cardiovascular or hepatic or renal disease or dysfunction. clinically significant gastrointestinal malabsorption syndromes such as chronic diarrhea, or celiac disease.

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Older Adults<br>Adults 60-80 years of age with body mass index > 30kg/m2 | Other: Body Composition Assessment<br>* Assessment of body composition using bioelectrical impedance analysis.<br>Other: Modified Physical Performance Test<br>* A test of physical functioning<br>Other: Hand grip strength<br>* A test of hand grip strength using a hand dynamometer.<br>Other: 6-minute walk test<br>* Self-paced test of walking capacity.<br>Procedure: Measurement of blood glucose and insulin<br>* Blood will be drawn for measurement of glucose and insulin.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fat mass | Measurement of fat mass | One day | 
| Fat-free mass | Measurement of fat-free mass | One day | 
| Modified Physical Performance Test | Assessment of physical function | One day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hand grip strength | Assessment of grip strength using a hand dynamometer | One day | 
| 6-minute walk test | Test of walking capacity assessed as distance covered in 6 minutes | One day | 
| Insulin resistance | Assessment of insulin resistance from blood glucose and insulin | One day |