The Effect of Exercise in Water on Functional Fitness in People With Parkinson's Disease

Study Overview
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Brief Summary
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The goal of this clinical trial study is to learn about the effect of aquatic exercise in parkinson's patients. The main questions it aims to answer are: What is the effect of exercise in water on balance in parkinson's patients? What is the effect of exercise in water on muscle strength in parkinson's patients? What is the effect of exercise in water on flexibility in parkinson's patients? Parkinson's patients in this study will do some functional tests. One group of them will do exercises in water 3 times weekly for 8 weeks.

Detailed Description
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Parkinson's disease (PD) is a progressive, neurodegenerative movement disorder characterised by the motor symptoms bradykinesia, tremor, rigidity, and postural instability. These are commonly associated with non-motor disturbances, neurobehavioural symptoms and reduced quality of life. Exercise is currently recommended as an additional strategy to manage PD-induced disability and is a key component of rehabilitation programs for people with PD. Aquatic exercise is another form of non-conventional exercise that has been growing in popularity in the context of neurorehabilitation.16 The aquatic setting offers specific mechanical advantages due to the hydrostatic and hydrodynamic principles of buoyancy, viscosity and drag. Due to its ability to enhance functional mobility whilst also being enjoyable,aquatic exercise has become a very popular form of physical training in the management of neurodegenerative disorders. Recent studies suggest that high-intensity interval training (HIIT) is promising for promoting neuroplasticity in human PD, with short training time and reduced burden. Biomarkers for neuroplasticity such as brain-derived neurotrophic factor (BDNF) and neurodegeneration (including neurofilament light chain ((NfL) and α-synuclein) may play a role, but their response to HIIT is not well-investigated. The aims of this study are to investigate the effects of HIIT exercises in water on balance, muscle strength, flexibility and gait speed in PD patients.

Official Title
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The Effect of of High Intensity Interval Training in Water on Functional Fitness in People With Parkinson's Disease: A Randomized Controlled Trial

Conditions
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Parkinson, Parkinson Disease, Neurologic Disorder

Intervention / Treatment
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* Other: Exercise in water


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: clinical diagnosis of idiopathic PD, from mild to moderate stages (severity from 1 to 4), according to the original version of the Hoehn & Yahr scale (HY)17, assessed by the neurologist Having medical certificate for performing physical activities and attending heated pools Exclusion Criteria: Having another neurological pathology Having limiting orthopedic or heart associated conditions changing physical activities or L-dopa-based drug intake parameters

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Participants will be randomly allocate to intervention group or control group and will be examined in the same way
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise group<br>Patients in the intervention group will do high intensity interval training (HIIT) in water. In this study, HIIT training will be short intervals (30 seconds) of movements and 15 seconds of rest.Exercises will be done in a floating position in the deep part. The intervention will be done 3 sessions weekly. The length will be 8 weeks. | Other: Exercise in water<br>* Participants will do some exercises in water for 30-60 minutes. Exercises will be performed at a moderate exercise intensity (12-14 on the Borg Rate of Perceived (RPE) Scale). All protocols are tailor-made based on each individual's needs and physical abilities.<br>|
| No Intervention: Control group<br>The patients will continue their usual medication and their usual physical activity. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of changes of Balance | Balance will be assessed by Berg Balance Scale test | Pre test and posttest (after 8 weeks) | 
| Rate of changes of Flexibility | Balance will be assessed by Sit & Reach test | Pre test and posttest (after 8 weeks) | 
| Rate of changes of Muscle Strength | Balance will be assessed by 30 s Sit to Stand test and Arm Curl test | Pre test and posttest (after 8 weeks) | 
| Rate of changes of Gait Speed | Balance will be assessed by 4-meters gait speed test | Pre test and posttest (after 8 weeks) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Parkinson Disease, Aqua Therapy, Balance, Neurological Disorders