Predisposing Factors for Post-stroke Epilepsy

Study Overview
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Brief Summary
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The goal of this observational study is to learn about epilepsy after a stroke (post-stroke epilepsy). The main questions it aims to answer are: What make some patients develop epilepsy after a stroke? Does sleep have an impact on the development of post-stroke epilepsy? Participants will undergo: Electroencephalography (EEG) Magnetic resonance imaging (MRI) Polysomnography (only patients) Blood tests will also be taken. The patient group will be compared to the healthy controls. Researchers will also look into medical records of stroke patients hospitalized at St. Olavs hospital and collect relevant information.

Detailed Description
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This study aims to study risk factors and clinical factors which might contribute to the development of post-stroke epilepsy. Researchers will look at the volume and size of the stroke-induced brain lesions and analyze inflammation markers. Patients and controls will undergo EEG and MRI. The correlations between sleep and epilepsy after a stroke will also be investigated through polysomnography. Relevant information about for instance age, comorbidities and NIHSS will be collected. Researchers will also collect relevant information from medical records of stroke patients hospitalized at St. Olavs hospital.

Official Title
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Predisposing Factors for Post-stroke Epilepsy

Conditions
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Post Stroke Epilepsy, Stroke, Epilepsy, Seizures

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: First time stroke patients with capacity to consent, admitted to the stroke unit at St. Olavs hospital. Modified Rankin Scale (mRS) ≤ 2 before the stroke Exclusion Criteria: Previous stroke or brain surgery Traumatic brain injuries Neurodegenerative diseases Brain tumors Epilepsy before the stroke Hydrocephalus Aphasia Serious psychiatric disorders MRI incompatibility and claustrophobia

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Stroke patients<br>Patients with first time stroke admitted to the stroke unit, St. Olavs hospital, Trondheim, Norway. The planned cohort size is 15-20 patients. | |
| Healthy controls<br>Age and gender matched healthy volunteers without previous stroke. The same number of healthy controls as recruited patients will be recruited through ads in the local newspaper. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post-stroke epilepsy | Minimum one documented case of post-stroke epilepsy after the stroke | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acute symptomatic seizure | Minimum one documented case of acute symptomatic seizure with epileptogenic activity recorded with EEG | 14 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases, Nervous System Disorders, Vascular Diseases