Electroretinogram and Retinal Vascular Changes After Cataract Surgery

Study Overview
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Brief Summary
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To compare electrophysiological and Optical coherence tomography angiography of optic disc and macula changes after uneventful phacoemulsification between normal and cataractus patients with primary open angle glaucoma.

Detailed Description
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Study design: A prospective, non randomized, interventional, comparative study, control based study. Location: Ophthalmology department, Sohag university hospital. In this prospective study, aiming to investigate Optical coherence tomography angiography and electrophysiological changes after cataract surgery in normal and patients with POAG with cataract 1 day before operation, 1 week and 3 months postoperatively. Methodology The study will include 50 patients with primary open angle glaucoma associated with cataract and 50 patients have cataract without glaucoma. Preoperative and postoperative evaluation: All patients will be subjected to the following: History taking including age, gender, family history, systemic diseases, previous medications or ophthalmic surgery. Detailed ophthalmological examination including: Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA) by Snellen's fraction and converted into logarithm of the minimal angle of resolution LogMAR, refraction, keratometry, slit lamp biomicroscopy for anterior segment, IOP measurement by applanation tonometer, and posterior segment (Fundus) examination. Examination of the angle of anterior chamber by goniolens. OCTA disc and macula Pattern ERG and multifocal ERG Surgical techniques: Patients will be subdivided into two groups: Group (A): normal Patients will undergo standard phacoemulsification surgery. Group (B): Patients with POAG will undergo standard phacoemulsification surgery. * phaco technology by using (WHITESTAR SIGNATURE PRO, Abbott, USA) OCT angiography will be done by (Optovue, Inc., Fremont, California, USA). Electrophysiology will be done by (Roland consult Retimap, Germany)

Official Title
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Changes of Electrophysiology and Optical Coherence Tomography Angiography in Primary Open Angle Glaucoma After Phacoemulsification

Conditions
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Primary Open Angle Glaucoma

Intervention / Treatment
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* Procedure: phacoemulsification


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged: 45-65 years old with cataract density doesn't interfere with Pre-operative imaging (N1-N2). Patients with primary open angle diagnosed for at least 2 years with glaucoma treatment associated with cataract (N1-N2). Exclusion criteria: s▪ patient with PACG. Previous intraocular surgery. Associated ocular or intra ocular inflammation Previous history of eye trauma. Associated intraocular pathology

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Control group<br>Control group who have cataract without Open Angle glaucoma Will under go phacoemulsification cataract surgery | Procedure: phacoemulsification<br>* cataract extraction<br>|
| Other: Open Angle glaucoma group<br>patients who have cataract and Open Angle glaucoma Will undergo phacoemulsification cataract surgery | Procedure: phacoemulsification<br>* cataract extraction<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pattern and multifocal electroretinogram and Optical coherence tomography angiography of optic disc and macula changes after phacoemulsification in primary open angle glaucoma | electrophysiology and optical coherence tomography angiography changes | before operation and 1st month, 3rd month post operative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual acuity and intra ocular pressure changes | visual acuity and intraocular pressure changes | before operation and 1st month, 3rd month post operative | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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OCTA: optical coherence tomography angiography, ERG: electroretinogram, POAG: primary open Angle glaucoma, V/A: visual acuity, IOP: intra ocular pressure