linjc16/ctgov huggingface dataset:
A Pragmatic Comparative Clinical Study to Determine the Optimal Initial Therapy for Multiple Myeloma

Study Overview
=================
Brief Summary
-----------------
This study evaluates the outcomes of patients undergoing initial therapy for multiple myeloma.

Detailed Description
-----------------
PRIMARY OBJECTIVE: I. Compare the overall survival between bortezomib, lenalidomide and dexamethasone (VRd), daratumumab, lenalidomide and dexamethasone (DRd) and daratumumab, bortezomib, lenalidomide and dexamethasone (DVRd) used as initial therapy for patients with newly diagnosed MM. OUTLINE: This is an observational study. Patients have their medical records reviewed on study.

Official Title
-----------------
A Pragmatic Comparative Clinical Study to Determine the Optimal Initial Therapy for Multiple Myeloma

Conditions
-----------------
Multiple Myeloma

Intervention / Treatment
-----------------
* Other: Non-Interventional Study


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Previously untreated active multiple myeloma starting a new treatment for the disease with one of the three established treatment regimens: VRd (bortezomib, lenalidomide, dexamethasone), DRd (daratumumab lenalidomide dexamethasone), or DVRd (daratumumab, bortezomib, lenalidomide, and dexamethasone) No prior treatment for myeloma Not receiving concurrent treatment for another active malignancy No more than 3 months from start of treatment
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Observational<br>Patients have their medical records reviewed on study. | Other: Non-Interventional Study<br>* Non-interventional study<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival | Overall survival, defined as the time from initiation of therapy to the time of death due to any cause, will be assessed by review of medical record, contacting the participant, or contacting the participant's local physician every 3 months for up to 10 years after participants starts the study. | Every 3 months, up to 10 years |
Pre-Surgical Grading System of Asherman Syndrome

Study Overview
=================
Brief Summary
-----------------
Utilising a novel pre-surgical grading system to class cases of asherman syndrome into 3 groups based on expected difficulty of surgery and potential prognostic outcomes.

Detailed Description
-----------------
Using the grading system, patients are classified into Mild, Moderate and Severe Asherman Syndrome. With the mild disease having the best prognostic value and a 1 step procedure, Moderate cases having a mediocre prognosis and usually multi-step procedure and Severe cases having a poor prognosis and counseled to other options. This observational study looks at the surgical outcomes following hysteroscopy for cases graded according to the new system to identify the accuracy of the classification in predicting the surgical success and prognostic value.

Official Title
-----------------
Asherman Syndrome: Pre-surgical Grading to Improve Gauge Prognostic Values and Improve Outcomes

Conditions
-----------------
Asherman Syndrome

Intervention / Treatment
-----------------
* Other: Classification


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Asherman Syndrome intra-uterine synechiae Exclusion Criteria: patients with a fundectomy or uterine reduction surgery.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Asherman Patients<br>Patients diagnosed with Asherman syndrome based on patient complaint of hypomenorrhea or amenorrhea and hysterosalpingography. | Other: Classification<br>* Novel Asherman Scoring Classification<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage Resumption of normal cavity on hystero-salpingography | assessing the improvement of the cavity of the uterus in hystero-salpingography | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Menses | Improvement in patients menstrual cycle | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Asherman Syndrome, Hysteroscopy, Intra-Uterine Surgery, Intra-Uterine Adhesions, Classification
Primary Dynamization Versus Standard Interlocking Intramedullary Nail in Treatment of Tibial Shaft Fractures in Adults

Study Overview
=================
Brief Summary
-----------------
fracture shfat tibia in adults treated by interlocking intramedullary nail by primary dynamic versus standard ways

Official Title
-----------------
Primary Dynamization Versus Standard Interlocking Intramedullary Nail in Treatment of Tibial Shaft Fractures in Adults

Conditions
-----------------
Tibial Shaft Fractures

Intervention / Treatment
-----------------
* Procedure: interlocking intramedullary tibial nail


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: adult patients (18-50) fractures with mid shaft or distal shaft tibial fracture AO type A1, A2 and A3 and minimal soft tisuue damage Exclusion Criteria: patients with comminuted fractures , old age more than 50 years , sclerotic bone , osteoporosis, osteopetrosis and bone deformity

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: primary dynamization interlocking intramedullary tibial nail<br> | Procedure: interlocking intramedullary tibial nail<br>* primary dynamization versus standard interlocking intramedullary tibial nail<br>|
| Active Comparator: standard interlocking intramedullary tibial nail<br> | Procedure: interlocking intramedullary tibial nail<br>* primary dynamization versus standard interlocking intramedullary tibial nail<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Primary Dynamization Interlocking Intramedullary Tibial Nail | use only distal screws away from fracture site | 12 months |
The Causes of Academic Excellence Concentrated in Dormitory

Study Overview
=================
Brief Summary
-----------------
This research will take the sophomore to senior students of Zhejiang University of Traditional Chinese Medicine as the research object to investigate the influence of dormitory atmosphere on the academic performance, scientific research achievements, and competition awards of dormitory members, analyze the path of straightforward-A student dormitory formation, and find out the current Weak links of college students' ideological and political education in dormitory culture construction, and explore how dormitory culture construction can promote the common progress of dormitory members

Official Title
-----------------
The Causes of Academic Excellence Concentrated in Dormitory

Conditions
-----------------
Peer Influence

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Sophomore-senior students of Zhejiang University of Traditional Chinese Medicine Exclusion Criteria: Non-straight-A student dormitory member
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Academic Excellence Concentrated in Dormitory | Academic performance (required course grade points)in units of credits, scientific research achievements are indexed by the number of papers produced, competition awards are based on the number of awards won,dormitory atmosphere is based on the combined score of each option of the questionnaire as an indicator（A is 0 points, B is 5 points……） | Zhejiang University of Traditional Chinese Medicine sophomore-senior students from admission to September 2023 |
Zolmitriptane as Prophylaxis for Chilhood Migraine

Study Overview
=================
Brief Summary
-----------------
zolmitriptane can be tried as prophylactic therapy of childhood migraine

Detailed Description
-----------------
90 children with migraine included in the study first group 30 received zolmitriptane second group 30 received topiramate third group 30 received valproate

Official Title
-----------------
Zolmitriptane as Prophylactic Therapy Childhood Migraine

Conditions
-----------------
Migraine

Intervention / Treatment
-----------------
* Drug: zolmitriptanee
* Drug: topiramate
* Drug: Valproate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: children with migraine - Exclusion Criteria: those who suffer from ischemic heart disease , or who have allergy to any of drugs used -

Ages Eligible for Study
-----------------
Minimum Age: 8 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: zolmitriptane<br>zolmitriptane tablet daily | Drug: zolmitriptanee<br>* zolmitriptane tablet daily<br>* Other names: zolmitriptane tablet;|
| Active Comparator: topiramate<br>topiramate tablet daily | Drug: topiramate<br>* topiramate once daily<br>* Other names: topiramate tablet;|
| Active Comparator: valproate<br>valproate once daily | Drug: Valproate<br>* valproate once daily<br>* Other names: Valproate tablet;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number and severity of migraine attacks |  | 6 months |
EFFECTIVENESS OF SINGLE DOSE ORAL DEXAMETHASONE VERSUS MULTIDOSE PREDNISOLONE FOR TREATMENT OF ACUTE EXACERBATIONS OF ASTHMA AMONG CHILDREN ATTENDING THE EMERGENCY DEPARTMENT OF CHILDREN HOSPITAL, ISLAMABAD

Study Overview
=================
Brief Summary
-----------------
In this Study i'll compare the effectiveness of two drugs used in acute exacerbation of asthma by their sideffects, complaince and improvement in the PRAM score. The better one would be adapted in our clinical practice.

Official Title
-----------------
EFFECTIVENESS OF SINGLE DOSE ORAL DEXAMETHASONE VERSUS MULTIDOSE PREDNISOLONE FOR TREATMENT OF ACUTE EXACERBATIONS OF ASTHMA AMONG CHILDREN ATTENDING THE EMERGENCY DEPARTMENT OF CHILDREN HOSPITAL, ISLAMABAD

Conditions
-----------------
Asthma in Children

Intervention / Treatment
-----------------
* Drug: Dexamethasone
* Drug: Prednisolone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: i.Ages 2 to 12years ii. Previous history of asthma as diagnosed by a physician. iii. Presentation with acute exacerbation of asthma with symptoms of cough, wheeze, dyspnoea and oxygen saturation of less than 95% and with PRAM score of more than or equal to 6 Exclusion Criteria: i.Critical or life-threatening asthma i.e. patient with silent chest, cyanosis, drowsy, unable to verbalize, marked tachycardia and respiratory distress. ii.Known TB exposure iii.Fever more than 39. 5°C iv.Use of corticosteroids in previous 4 weeks v.Significant co-morbid disease: lung, cardiac, immune, liver, endocrine, neurological or psychiatric

Ages Eligible for Study
-----------------
Minimum Age: 2 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Oral Single dose dexamethsone in acute exacerbation of asthma<br> | Drug: Dexamethasone<br>* Oral Dexamethasone a longer and potent corticosteroid with lesser sideffects and good compliance<br>|
| Active Comparator: Oral Multidose Prednisolone in acute exacerbation of asthma<br> | Drug: Prednisolone<br>* Oral Multidose Prednisolone<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improvement in PRAM score | PRAM will be evaluated at day 4 | 4 days |
Reliabılıty,Validity Of The Turkish Version Of The NIH-Minimal Dataset

Study Overview
=================
Brief Summary
-----------------
This study, we performed the Turkish version validity and reliability of the NIH Task Force's Recommended Multidimensional Minimal Dataset

Detailed Description
-----------------
Low back pain is defined as the pain that can occur in the region between the lower border of the scapula and the hip, sometimes spreading to the lower extremities, which causes activity limitation and is one of the most common health problems in the society. Appropriate use of assessment questionnaires is one of the most important steps in the evaluation of the functional level of the patient and in deciding on an effective treatment protocol. The purpose of our study is to determine the Turkish version, validity and reliability of NIH Task Force's Recommended Multidimensional Minimal Dataset. 200 patients with chronic low back pain were included in the study. Test-retest and internal consistency analysis were conducted to determine the reliability of the questionnaire.

Official Title
-----------------
Translation, Cross-cultural Adaptation and Validation of the Turkish Version of NIH Task Force's Recommended Multidimensional Minimal Dataset for Research on Chronic Low Back Pain

Conditions
-----------------
Low Back Pain

Intervention / Treatment
-----------------
* Other: NIH Task Force's Recommended Multidimensional Minimal Dataset


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Having a low back pain Literate Exclusion Criteria: pregnant, canser trauma

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients group<br>Patients with low back pain (18-65 years) | Other: NIH Task Force's Recommended Multidimensional Minimal Dataset<br>* Questionnaire<br>* Other names: Turkish version of the NIH Task Force's Recommended Multidimensional Minimal Dataset;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Roland Morris disability questionnaire | Roland Morris Disability Questionnaire, a widely used health status measure for low back pain. The RMDQ can be used in research or clinical practice. | 10 minute | 
| Oswestry Low Back Pain Disability Questionnaire | The Oswestry Disability Index (ODI) has become one of the principal condition-specific outcome measures used in the management of spinal disorders | 10 minute | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
validity, reliability, low back apain, translation
Early Perioperative Quality Of Recovery After Hip and Knee Arthroplasty: a Retrospective Comparative Cohort Study

Study Overview
=================
Brief Summary
-----------------
Hip and knee replacements are indicated to improve long-term quality of life and pain. These long-term results may depend on the quality of the initial postoperative recovery. However, early postoperative health status after total hip arthroplasty (THA) and total knee arthroplasty (TKA) is not accurately described. Through this retrospective study, the investigators wanted to describe the perioperative state of health monitored using the QoR-15 questionnaire for THA and TKA patients from the perioperative moment to postoperative day 28.

Official Title
-----------------
Early Perioperative Quality Of Recovery After Hip and Knee Arthroplasty: a Retrospective Comparative Cohort Study

Conditions
-----------------
Arthroplasty, Hip Replacement, Arthroplasty, Knee Replacement

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patient (age ≥ 18 years) Having benefited from an ATG or ATH at Strasbourg University Hospital between March 1, 2020 and December 31, 2022 Tracked with QoR-15 score Patient not opposing the reuse of his data for scientific research purposes Exclusion Criteria: Refusal to participate in the study Patient admitted to THA for a hip fracture Patient admitted for multiple THA or TKA

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mean QoR-15 score at the preoperative period and postoperative days 1, 3, 14 and 28 | Perioperative health status monitored using the QoR-15 questionnaire for THA and TKA patients from perioperative time to postoperative day 28 | At the preoperative period and postoperative days 1, 3, 14 and 28 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Arthroplasty, Hip Replacement, Knee Replacement, QoR-15 questionnaire
Monitoring Response to Neoadjuvant Chemotherapy in Breast Cancer Using Ultrafast DCE-MRI

Study Overview
=================
Brief Summary
-----------------
The study will assess whether changes in kinetic parameters of tumor and peritumoral vasculature using ultrafast dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) during neoadjuvant chemotherapy (NAC) are predictive of pathologic complete response (pCR) in patients with breast cancer appropriate for NAC. pCR is defined as having no residual invasive breast cancer or ductal carcinoma in situ.

Official Title
-----------------
Monitoring Response to Neoadjuvant Chemotherapy in Breast Cancer Using Ultrafast Dynamic Contrasted-Enhancement Magnetic Resonance Imaging

Conditions
-----------------
Breast Cancer

Intervention / Treatment
-----------------
* Other: Response monitoring


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female; Age 18 years or older; Diagnosis of invasive breast cancer by ultrasound guided biopsy; 3. Planed for receiving neoadjuvant chemotherapy (NAC) 4. Planned definitive breast surgery following completion of NAC. Exclusion Criteria: Stage IV breast cancer; Previous ipsilateral breast cancer; Previous treatment (chemotherapy or radiation) to involved breast; Medically unstable; Pregnant or nursing.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Response monitoring|Other: Response monitoring (no intervention)|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complete Pathologic Response (pCR) | The primary aim of this feasibility study is to determine whether ultrafast dynamic contrasted-enhancement magnetic resonance imaging (DCE-MRI) at baseline prior to first cycle neoadjuvant chemotherapy (NAC), after first cycle NAC, and prior to second cycle NAC can accurately predict complete pathologic response (pCR) in women with breast cancer. | 6 Months Post Surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Image Quality | The second aim of this feasibility study is to determine whether ultrafast dynamic contrasted-enhancement magnetic resonance imaging (DCE-MRI) can provide the relatively high resolution, high contrast-noise ration, and good contrast with ultrafast DCE-MRI | 6 Months Post Surgery |