Observation and Interactions Between Cardio-respiratory and Motor Transitions at the Limits of Moderate Exercise.

Study Overview
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Brief Summary
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The goal of this observational study is to learn about physiological transitions around the limit of moderate exercise intensity on cardiac, respiratory and motor modalities, in healthy population. The main questions it aims to answer is: is it possible to define criteria on cardiac, respiratory and motor modalities to identify transitions? are those transitions visible on embedded and non-intrusive monitoring equipment? are those identified transitions somehow connected to first ventilatory threshold (VT1)? Participants will do a sub-maximal effort test on cycloergometer calibrated to make them cross their first ventilatory threshold.

Detailed Description
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Cycling is a commonly prescribed activity when it comes to physical activities for rehabilitation. Because it is soft and progressive effort, cycling suits well for patients with chronic conditions (diabete, cancer, fibromyalgia, ...) For safety and effectiveness of the activity, it is necessary to prescribe activity at a regular and moderate intensity. This can be achieved by personalizing intensities to match specifically the patient health condition in order to build an efficient and progressive rehabilitation program. Physical activity prescription rely on four pillars: frequency, duration, volume and intensity. While first three pillars are quite easy to regulate,effort intensity is harder to handle on training planning. It is harder to measure, and defining personalized guideline for practice is more complex. It is known that first ventilatory threshold (VT1) is a individualized marker representing the higher limit of moderate intensity effort zone. It makes it an interesting tool for the prescription of intensity for retraining purposes: it guaranties a safe practice, intense enough to make beneficial physiological adaptations for the patient. In this retraining context and with this study, we aim to identify markers of this transition on cardiac, respiratory and motor modalities, with embedded and non intrusive equipment, during a sub-maximal effort test in laboratory.

Official Title
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Observation et Mise en Relation Des Transitions Cardio-respiratoires et Motrices à la frontière de l'Exercice modéré

Conditions
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Healthy

Intervention / Treatment
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* Other: Signal acquisition


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Capability to cycle during 20min No contraindication to cycling at a moderate pace No acute pathology (less than 2 years old) No cardiac or respiratory chronic pathology No locomotive problem on the spine or the lower limbs No recent injuries (less than 2 months) Stature compatible with the use of the plethysmography t-shirt Exclusion Criteria: Pregnant (urine strip test) or breastfeeding women Persons referred to in articles L1121-5 to L1121-8 of the CSP (protected persons) person deprived of liberty by judicial or administrative decision, person subject to a legal protection measure Subject being excluded from another study Subject who reached the ceiling of 4500 euros due to their participation in other studies involving human in the past 12 months

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 64 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Volunteers<br>Subjects who will agree to participate to the study will be healthy subject with no particular antecedents. Subjects will be enroled for two sessions with a 20 min monitoring phase in each session, to coect physiological data with non invasive sensors. | Other: Signal acquisition<br>* Synchronized signals from cardiac, respiratory and movements non invasive measurements. One acquisition is 20 minutes long, and each subject participate to two sessions, separated by 1 to 15 days.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Database of physiological signals | Synchronized signals from embedded and non-intrusive connected devices for cardiorespiratory and motricity measurements and equivalent laboratory measurements during cycling on a cyclo-ergometer | 20 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of the feeling of wearing equipment | Questionnaire at the end of each session to assess the comfort / discomfort wearing the equipment used during the test | 15 minutes | 
| Criteria for the observation of a respiratory transition | Feasibility of the transition detection, repeatability of the detection with the respiratory criteria | 6 months | 
| Criteria for the observation of a cardiac transition | Feasibility of the transition detection, repeatability of the detection with the cardiac criteria | 6 months | 
| Criteria for the observation of a motricity transition | Feasibility of the transition detection, repeatability of the detection with the motricity criteria | 6 months | 
| Multi-modal prediction of the first ventilatory threshold | Correlation with the measurement of ventilatory threshold 1 (VT1) | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Retraining, Physical Activity, First Ventilatory Threshold, Moderate Intensity Domain, Physiological Transitions, Motricity, Cardiorespiratory, Connected Objects