Zhejiang Nutrition and Health Study

Study Overview
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Brief Summary
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This project aims to explore the relationship between healthy lifespan and nutrition through a 10-year longitudinal study in Zhejiang Province. The cohort will include individuals in a wide range of age groups. The demographic, diet, lifestyle information, health status, and corresponding bio-samples will be collected carefully. It will give a deeper insight to the relation between nutrition and healthy aging and longevity. Ultimately, this research will contribute to evidence-based nutrition interventions to improve health outcomes and enhance quality of life.

Detailed Description
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This project aims to elucidate the relationship between healthy lifespan and nutrition through the establishment of a large-scale cohort of participants and longitudinal follow-ups spanning around 10 years in Zhejiang Province. The cohort will comprise individuals in a wide range of age groups starting at 6 years old. The participants will provide demographic information, anthropometry measurements, detailed diet, lifestyle data and health status, including 3-day dietary records and long-term food intake frequency recalls. Integrated with previous information, diverse bio-samples will also be collected to establish a multi-dimensional biobank. It will give a deeper insight to the relation between nutrition and healthy aging and longevity. Ultimately, this research will contribute to the development of evidence-based nutrition designed to improve health outcomes and enhance the quality of life for individuals of all ages.

Official Title
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Zhejiang Nutrition and Health Study: Nutrition and Lifespan Study (NuLife Study)

Conditions
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Metabolic Disease, Cardiovascular Diseases, Healthy Aging

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Chinese citizens who have resided in the surveyed area for at least 6 months before the survey within the last 12 months. Aged 6 years or older. They are included as resident households, which are comprised of people living together in one place based on family relationships, and at least one resident with permanent household registration. Exclusion Criteria: Residents living in functional zones such as construction worker dormitories, military barracks, schools, nursing homes, etc.

Ages Eligible for Study
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Minimum Age: 6 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Occurrence of cardio-metabolic diseases | The investigators will track for occurrence of cardio-metabolic diseases by follow-up surveys collected by the Zhejiang Center for Disease Control and Prevention. | up to 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in fasting blood glucose | Fasting glucose will be examined in mmol/L. | Every other year， up to 10 years | 
| Changes in fasting blood HbA1c | Fasting blood HbA1c will be examined in % | Every other year， up to 10 years | 
| Changes in fasting lipid metabolism | Triglyceride, cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol will be examined in mmol/L. | Every other year， up to 10 years | 
| Changes in fasting blood highly sensitive C-reactive protein (CRP) | CRP will be examined in mg/L. | Every other year， up to 10 years | 
| Changes in body mass index | Body mass index (BMI) will be calculated in kg/m^2 | Every other year， up to 10 years | 
| Changes in blood pressure | Blood pressure, including systolic and diastolic blood pressure, will be measured in mmHg | Every other year， up to 10 years | 
| Changes in gut microbiome profiling | 16S rRNA and/or shotgun metagenomic sequencing will be performed in stool samples. | Every other year， up to 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Nutrition, Health, Healthy lifespan