The Effect of Bilateral Sphenopalatine Ganglion Block on Postoperative Pain in Patients to be Subject to Septorhinoplasty Surgery

Study Overview
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Brief Summary
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The aim of this study is to examine the effects of bilateral sphenopalatine ganglion block on surgical conditions, hemodynamics, intraoperative and postoperative analgesic use, recovery characteristics, and postoperative pain during septorhinoplasty under general anesthesia. The study was planned as double-blind, randomized, controlled. 72 patients who will undergo septorhinoplasty surgery will be collected. (g power analysis was performed.) Evaluation of the effectiveness of bilateral sphenopalatine ganglion block was planned. Patients will be divided into 2 equal groups (36 patients). After the induction of general anesthesia, one group (Group: 1) will be administered 8mg dexamethasone and 10mg bupivacaine submucosal, the other group (group:2) will be administered 4 cc saline. aspects will be evaluated.

Official Title
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The Effect of Bilateral Sphenopalatine Ganglion Block on Postoperative Pain in Patients to be Subject to Septorhinoplasty Surgery

Conditions
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Anesthesia of Mucous Membrane

Intervention / Treatment
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* Procedure: Bilateral endoscopic sphenopalatine ganglion block
* Procedure: placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - patients with an ASA score of I-II and between the ages of 17-45 years, who were to undergo general anesthesia with desflurane, were included in the study. Exclusion Criteria: Patients aged <17 and >45 years, patients with liver and/or kidney failure, obese patients (BMI >30), trauma patients, ASA III-IV patients, patients with bleeding disorders, those using drugs that may affect the coagulation system, patients with cardiomyopathy, cerebrovascular disease, immobility, and malnutrition were excluded from the study.

Ages Eligible for Study
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Minimum Age: 17 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Endoscopic bilateral sphenopalatine ganglion block<br>After the induction of general anesthesia, one group (Group: 1) will be administered 8mg dexamethasone and 10mg bupivacaine submucosal, | Procedure: Bilateral endoscopic sphenopalatine ganglion block<br>* After the induction of general anesthesia, one group (Group: 1) will be administered 8mg dexamethasone and 10mg bupivacaine submucosal,<br>|
| Placebo Comparator: Placebo<br>Placebo group (group:2) will be administered 4 cc saline. aspects will be evaluated. | Procedure: placebo<br>* Placebo group (group:2) will be administered 4 cc saline. aspects will be evaluated.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Numeric Rating Scale | They will be numbered from 1 to 10. 1 mildest 10 most severe pain | Postoperative 0-2 hours, 2-8 hours,8-24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Riker Agitation Scale | 7 Dangerous Agitation 6 Very Agitated 5 Agitated 4 Calm and Cooperative 3 sedated 2 Very Sedated A 1 Unarousable | Immediately after extubation | 
| mean arterial pressure | mmhg | when you come to the operating room table after anesthesia induction Intraoperative 30 minutes after extubation | 
| heart rate | beats\minute | when you come to the operating room table after anesthesia induction Intraoperative 30 minutes after extubation | 
| intraoperative remifentanil consumption | The intraoperative ultiva infusion dose was recorded to the patient. | intraoperative | 
| edema questionnaire | Periorbital edema was evaluated as present or absent questionnaire | Postoperative 0-2 hours, 2-8 hours,8-24 hours | 
| hematoma questionnaire | Hematoma was evaluated as present or absent questionnaire | Postoperative 0-2 hours, 2-8 hours,8-24 hours | 
| vomiting questionnaire | was evaluated as present or absent questionnaire | Postoperative 0-2 hours, 2-8 hours,8-24 hours | 
| Oral analgesic use | Analgesic use in the first 24 hours was questioned. | In the first 24 hours after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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sphenopalatine ganglion block, septhorhinoplasty, general anesthesia