Cold Snare Polypectomy for Small Bowel Polyps in Patients With Peutz-Jeghers Syndrome

Study Overview
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Brief Summary
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This study aims to evaluate the feasibility and safety of Cold snare polypectomy for removing 5-9mm small intestinal polyps in patients with Peutz-Jeghers Syndrome (PJS),in order to provide some reference for clinical strategy of endoscopic treatment of small intestinal polyps in PJS patients, and may prolong the follow-up period of PJS patients Intervals.

Official Title
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Feasibility and Safety Analysis of Cold Snare Polypectomy in 5-9mm Small Intestinal Polyp Resection in Patients With Peutz-Jeghers Syndrome: A Prospective, Interventional Study

Conditions
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Peutz-Jeghers Syndrome, Small Bowel Polyp

Intervention / Treatment
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* Procedure: Cold snare polypectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 8-60, male or female. Diagnosed with Peutz-Jeghers Syndrome Undergo enteroscopy for small bowel polypectomy. Exclusion Criteria: Absence of at least one study polyp (5-9mm stubby pedicle, wide pedicle and sessile small bowel polyps); Be evaluated during enteroscopy for requiring surgical intervention (such as endoscopically difficult to handle giant polyps, intussusception, etc.)； With more than 50 polyps ≥1cm found in this enteroscopy examination; The polyp has been confirmed to be malignant by pathology, or highly suspicious of malignant transformation under endoscopy; Receiving anticoagulant therapy during this treatment; Unable or unwilling to provide informed consent.

Ages Eligible for Study
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Minimum Age: 8 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cold snare polypectomy group<br> | Procedure: Cold snare polypectomy<br>* For eligible patients, use cold snare polypectomy to resect 5-9mm short-pedicled, broad-pedicled or sessile small bowel polyps<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of complications in the application of cold snare polypectomy for 5-9mm small bowel polypectomy in patients with PJS | The complications include complications during CSP and complications occurring within 28 days after enteroscopy | 28 days after the procedure | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of complications during cold snare polypectomy for 5-9mm small bowel polypectomy | Including intraoperative bleeding (defined as active haemorrhage for more than 30s), perforation immediately, etc. | Immediately after the procedure | 
| Incidence of complications within 28 days after enteroscopy | Including Delayed bleeding, delayed perforation, pancreatitis, electrocoagulation syndrome. | 28 days after the procedure |