Evaluation of Human Papillomavirus Vaccine Coverage in Girls and Young Women With Chronic Disease

Study Overview
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Brief Summary
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The main objective of the study is to determine the vaccination coverage rate for human papillomavirus in adolescents aged 11 to 20 with chronic disease and treated at the Necker-Enfants Malades Hospital, compared to a population witnessed adolescent girls aged 11 to 20 years without chronic disease.

Detailed Description
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Girls and young women with chronic condition are at higher risk for infections that can be prevented by vaccination. Human papillomavirus infection is very common, one of the three most common in the general population. A vaccine exists to significantly prevent this infection and its complications. In France, it is advisable to vaccinate girls and boys from the age of 9 years and as soon as possible in the case of acquired immunodeficiency since these patients are more likely to be suffering from cancer induced by the human papillomavirus. In France, the overall rate of vaccination coverage for girls is 21%, which is significantly lower than in several other industrialized countries. The vaccination coverage rate for human papillomavirus in patients with chronic diseases may be even lower. The main objective of the study is to determine the vaccination coverage rate for human papillomavirus in adolescents aged 11 to 20 with chronic condition and treated at the Necker-Enfants Malades Hospital, compared to a population witnessed adolescent girls aged 11 to 20 years without chronic disease.

Official Title
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Evaluation of Human Papillomavirus Vaccine Coverage in Girls and Young Women With Chronic Disease

Conditions
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Human Papillomavirus Vaccine, Chronic Condition

Intervention / Treatment
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* Other: Questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Information and non-opposition of major patients and holders of parental authority of minor patients and minor patients Girls and young women aged 11 to 20 To be followed at the Necker-Enfants Malades Hospital (chronic condition group) To be followed at the Specialized Medical Center for Children and Adolescents (control group) Have a chronic condition (chronic condition group) : Diabetes type 1 Metabolic diseases Patients followed in immuno-hematology Cystic Fibrosis Sickle Kidney transplant Heart Disease Inflammatory bowel diseases Rare anorectal and pelvic anomalies Live in France Comprehension of the French language (oral and written) Exclusion Criteria: Have a contraindication to the HPV vaccine - Gardasil 9 (Vidal Hoptimal, 2018) Have a contraindication to the HPV vaccine - Gardasil (Vidal Hopitmal, 2018) Have a contraindication to HPV vaccine - Cervarix (Vidal Hoptimal, 2018)

Ages Eligible for Study
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Minimum Age: 11 Years
Maximum Age: 20 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Chronic condition<br>Girls and young women between the ages of 11 and 20 suffering from chronic condition | Other: Questionnaire<br>* Questionnaire on human papillomavirus vaccine status of girls and young women and modalities of the vaccination or reason of the non-vaccination. The questionnaire is completed by the patient.<br>|
| Control<br>Girls and young women between the ages of 11 and 20 in good health | Other: Questionnaire<br>* Questionnaire on human papillomavirus vaccine status of girls and young women and modalities of the vaccination or reason of the non-vaccination. The questionnaire is completed by the patient.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Immunization coverage rate for human papillomavirus vaccine | Percentage of patients with or without a chronic illness who have received HPV vaccination (complete vaccination schedule). | Day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intention of vaccination by human papillomavirus vaccine by the usual health professionals | Percentage of patients with or without a chronic illness who have been offered HPV vaccination. | Day 1 | 
| Category of health professionals offering vaccination by human papillomavirus vaccine | Patients with or without a chronic illness to whom vaccination has been offered/prescribed : Percentage of vaccination offered/prescribed by the general practitioner Vaccination percentage proposed/prescribed by the pediatrician, Vaccination percentage proposed/prescribed by the gynecologist, Percentage of vaccination proposed/prescribed by the specialist doctor, Percentage of vaccination offered/prescribed by another healthcare professional. | Day 1 | 
| Reasons for non-vaccination by human papillomavirus vaccine | Patients suffering from a chronic illness or not and not vaccinated: Percentage of patients not vaccinated due to fear/apprehension, Percentage of patients not vaccinated because they did not know this vaccine, Percentage of patients not vaccinated because they are against vaccination, Percentage of patients not vaccinated due to lack of time. | Day 1 | 
| Description of parameters that may impact vaccination coverage for human papillomavirus vaccine | Description of patients with or without a chronic illness and vaccinated or not against HPV Average age of patients at the time of inclusion, Socio-professional category of parents (father's and mother's profession), Average age at menarche, Assessment of risk behaviors (percentage of patients who smoke, percentage of patients who consume alcohol), Percentage of patients who have started their sexual life, Average age at first sexual intercourse, Percentage of patients followed by a pediatrician, Percentage of patients followed by a general practitioner, Percentage of patients followed by a gynecologist. | Day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Human papillomavirus vaccine, Young women with chronic condition, Vaccination coverage rate