The Impact of Climate Environment in Different Latitudes on the Occurrence of PICC Complications

Study Overview
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Brief Summary
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In this study, eligible subjects were randomly assigned to the experimental or control group through randomization (1:1). Under the guidance of electrocardiographic Doppler ultrasound guided puncture and catheterization (EDUG) technology, the tunnel puncture method was compared with the conventional puncture method. The two groups of patients were observed and evaluated intraoperative and postoperative 7 ± 3 days, 30 ± 7 days, 60 ± 10 days, and 90 ± 10 days 120 ± 10 days (if any) and the occurrence of complications during extubation or unplanned extubation at the end of treatment, comparing cases in the north and south, as well as complications related to different catheterization methods

Official Title
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The Impact of Climate Environment in Different Latitudes on the Occurrence of PICC Complications and Intervention Measures - Prospective, Multicenter, Randomized Controlled Study

Conditions
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Cancer, Thrombus, Phlebitis, Infections

Intervention / Treatment
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* Device: tunneled PICC
* Device: routine PICC


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged ≥ 18 years old; Patients who follow medical advice and require PICC catheterization; Patients who have not participated in other clinical studies; Patients who voluntarily participate in this clinical study and can cooperate with clinical follow-up; There are no serious cardiovascular diseases, such as atrial fibrillation, pulmonary heart disease, and other P-wave abnormalities before catheterization, as well as severe heart conduction block Exclusion Criteria: Known allergies to catheter materials; There is a history of infection, injury, and radiation therapy at the puncture site; The puncture site has a history of venous thrombosis or surgery; Severe abnormal coagulation function; Superior vena cava compression syndrome; Surgical side limbs of breast cancer patients undergoing radical mastectomy or axillary lymph node dissection; Heart pacemaker and arteriovenous fistula on the same side of the limb; Patients or patients' family members refuse to sign the informed consent form.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: trial group<br> | Device: tunneled PICC<br>* Tunneled PICC is a type of PICC catheterization technique that involves establishing a subcutaneous tunnel to keep the outlet of the catheter away from the puncture site<br>|
| Active Comparator: control group<br> | Device: routine PICC<br>* Peripherally inserted central venous catheterization is a technique that involves inserting PICC through the peripheral vein and infusing drugs into the central vein through a catheter.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| rate of complications |  | 120 days after operation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| time of catheter retention |  | 7, 30, 60, 90 and 120 days after operation |