Safety and Efficacy of High Flow Nasal Canula in Patients With Mild Hypercapnia

Study Overview
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Brief Summary
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Evaluate safety and efficacy of application ( high flow nasal canula) in cases with mild hypercapnia, included 30 patients who were hospitalized in Mansoura University chest department with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30) of different pulmonary disease categories (Chronic obstructive pulmonary disease acute exacerbation, pneumonia, Interstitial lung diseases, etc).

Official Title
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Safety and Efficacy of High Flow Nasal Canula in Patients With Mild Hypercapnia

Conditions
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Hypercapnia

Intervention / Treatment
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* Device: high flow nasal canula


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with mild Hypercapnia Exclusion Criteria: Excluded cases had age less than 18 years or pediatric group . patients with their mental state altered, confused, comatose, severe agitation or non cooperative Cases with moderate or severe Hypercapnia cases in need for immediate invasive mechanical ventilation cases with respiratory rate more than 35 breath per minute. cases with Respiratory exhaustion , fatigue , excess use of respiratory accessory muscles Shock , hemodynamic instability, post arrest cases, cases with facial trauma or severe nasal deformity, Patients with sleep breathing disorders or upper airway obstruction patients with history of home ventilation prior admission

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30)<br>with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30) of different pulmonary disorders | Device: high flow nasal canula<br>* administration of high flow nasal canula at initial flow 35 liters per minute and Fio2 (fraction of inspired oxygen of 50%) with titration to reach oxygen saturation of 88-92%.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Arterial Blood Gases changes | The primary outcome was concerned about changes in Arterial Blood Gases in first 24 h after admission and the same changes 48 h after admission. | 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants in need for ventilation | Secondary outcome was concerned about need to non invasive mechanical ventilation or invasive mechanical ventilation. | 7 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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hypercapnia, high flow nasal canula