Improving the Intraoperative Diagnosis Accuracy of Invasiveness for Small-sized Lung Adenocarcinoma

Study Overview
=================
Brief Summary
-----------------
The goal of this observational study is to improve the intraoperative diagnosis accuracy of invasiveness for small-sized lung adenocarcinoma by combining multi-modal information. The main question it aims to answer is whether multi-modal information have great value of prediction on the invasiveness for small-sized lung adenocarcinoma. Since a promising limited resection is largely based on intraoperative frozen section diagnosis, there is a growing demand on the high-accuracy of timely pathology diagnosis. The multi-modal information of participants will be collected retrospectively.

Official Title
-----------------
Improving the Intraoperative Diagnosis Accuracy for Pre-invasive and Invasive Small-sized Lung Adenocarcinoma Node by Combining Multi-modal Information

Conditions
-----------------
Lung Adenocarcinoma, Stage I

Intervention / Treatment
-----------------
* Diagnostic Test: Invasiveness diagnosis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: CT examination within 3 months before surgery Patients with operable clinical stage I lung cancer No previous treatment in the lungs or any other organ ≥ 20 years and ≤ 80 years old Tumor less than 3cm in diameter on thin-slice (0.625-1 mm) CT images Lung adenocarcinoma confirmed by surgical resection and histopathological diagnosis Exclusion Criteria: Marked artifacts on CT images History of preoperative treatment Incomplete clinical information or DICOM images History of other malignant tumors Lung cancer associated with cystic airspaces

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| adenocarcinoma in situ<br>Adenocarcinoma in situ is defined as a small (≤3 cm) localized nodule with lepidic growth, mostly non-mucinous. | Diagnostic Test: Invasiveness diagnosis<br>* To predict the invasiveness of patients with small-sized lung adenocarcinoma intraoperatively based on multi-modal information.<br>|
| minimally invasive adenocarcinoma<br>Minimally invasive adenocarcinoma defined as a small (≤3 cm) solitary adenocarcinoma with a predominantly lepidic pattern and ≤5 mm invasion in greatest dimension. | Diagnostic Test: Invasiveness diagnosis<br>* To predict the invasiveness of patients with small-sized lung adenocarcinoma intraoperatively based on multi-modal information.<br>|
| invasive adenocarcinoma<br>Invasive adenocarcinoma is a malignant epithelial tumor with glandular differentiation, mucin production, or pneumocyte marker expression. The tumors show an acinar, papillary, micropapillary, lepidic, or solid growth pattern, with either mucin or pneumocyte marker expression. The invasive ademocarcinoma component should be present in at least one focus measuring >5mm in greatest dimension. | Diagnostic Test: Invasiveness diagnosis<br>* To predict the invasiveness of patients with small-sized lung adenocarcinoma intraoperatively based on multi-modal information.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Final pathology diagnosis of the paraffin section stained with HE | The final pathology diagnosis after resection | Immediately after operation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
multi-modal information, lung adenocarcinoma, intraoperative diagnosis, invasiveness