Biomarkers and Risk Factors for Perioperative Neurocognitive Dysfunction in Elderly Patients

Study Overview
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Brief Summary
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Basic information and biological samples of patients were collected preoperatively and intraoperatively, and patients were divided into case and control groups by cognitive function assessment postoperatively, and risk factors and biomarkers of perioperative cognitive dysfunction were derived by analyzing and statistically processing basic information and biological samples.

Official Title
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Biomarkers and Risk Factors for Perioperative Neurocognitive Disorders in Elderly Non-neurosurgical Patients

Conditions
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Perioperative Neurocognitive Dysfunction

Intervention / Treatment
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* Diagnostic Test: Pittsburgh sleep quality index
* Diagnostic Test: Self-rating depression scale
* Diagnostic Test: Montreal Cognitive Assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age more than or equal to 65 years old ASA classification Ⅰ Ⅲ grade Exclusion Criteria: History of previous Craniocerebral surgery or Craniocerebral trauma Inability to successfully complete preoperative psychological function tests Those who are severely deaf, speech impaired and otherwise unable to communicate.

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with perioperative neurocognitive dysfunction<br> | Diagnostic Test: Pittsburgh sleep quality index<br>* The scale is suitable for evaluating sleep quality in patients with sleep disorders and psychiatric disorders, as well as for assessing sleep quality in the general population.<br>Diagnostic Test: Self-rating depression scale<br>* The scale is easy to use, can fairly intuitively reflect whether the patient has depression and the degree of depression, has been widely used in outpatient gross screening, mood state assessment.<br>Diagnostic Test: Montreal Cognitive Assessment<br>* The scale is a tool used for rapid screening of mild cognitive dysfunction to identify patients with preoperative cognitive dysfunction<br>|
| Patients without perioperative neurocognitive dysfunction<br> | Diagnostic Test: Pittsburgh sleep quality index<br>* The scale is suitable for evaluating sleep quality in patients with sleep disorders and psychiatric disorders, as well as for assessing sleep quality in the general population.<br>Diagnostic Test: Self-rating depression scale<br>* The scale is easy to use, can fairly intuitively reflect whether the patient has depression and the degree of depression, has been widely used in outpatient gross screening, mood state assessment.<br>Diagnostic Test: Montreal Cognitive Assessment<br>* The scale is a tool used for rapid screening of mild cognitive dysfunction to identify patients with preoperative cognitive dysfunction<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perioperative neurocognitive dysfunction | Identification of patients who develop perioperative neurocognitive disorders after surgery by postoperative follow-up with cognitive function tests | 1 year postoperative |