Effects of Intrapulmonary Percussive Ventilator on Respiratory Function

Study Overview
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Brief Summary
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The goal of this clinical trial is to prove the benefit of intrapulmonary percussive ventilator in healthy volunteers. The main questions are: How can intrapulmonary percussive improve lung function？ What is the subjective feeling through intrapulmonary percussive? Participants will be undergoing treatment of intrapulmonary percussive. Then they will be assessed for lung function and EIT before and after intrapulmonary percussive.

Official Title
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Effects of Intrapulmonary Percussive Ventilator on Respiratory Function: an Experiment in Healthy Volunteers

Conditions
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Airway Clearance Impairment

Intervention / Treatment
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* Device: Intrapulmonary Percussive ventilator


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: No respiratory system, heart disease Well cooperate with the MateNeb Exclusion Criteria: No respiratory illness such as influenza, pneumonia, asthma, bronchitis within the last month Couldn't finish three times pulmonary function test

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: experimental group<br>The experimental group will undergo intrapulmonary percussive therapy | Device: Intrapulmonary Percussive ventilator<br>* The volunteers will undergo three minutes low frequency and high frequency intrapulmonary percussive treatments.<br>* Other names: MateNeb;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pulmonary function test | This test can assess the volunteer's lung ventilation and diffusion function.For example the max vital capacity (VCMAX),Forced vital capacity(FVC),Forced expiratory volume in one second(FEV1),functional residual capacity(FRC-SB),diffusion capacity of lung for carbon monoxide(DLCO) and so on. | through study completion, an average one hour | 
| Electrical Impedance Tomography of Pulmonary(EIT) | EIT is a relatively advanced non-invasive monitoring technique for the lung function. This technology uses a strap attached to the chest to monitor electrical at 16 locations. The Ventilation in each area resistance of the lung is quantified according to the electrical resistance | through study completion, an average one hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The safety and comfort | Whether the technique has adverse reactions. How do the volunteers feel? We used a scale of 1 to 4 to show how the volunteers felt. 1 is the worst feeling. The volunteers were no longer willing to undergo the treatment. 4 means the volunteers felt better and breathed easier after the treatment. Be willing to undergo endoairway shock therapy again. | The treatment was scored once after the participants completed both low and high frequency intrapulmonary percussive.Up to one week. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Intrapulmonary percussive, Healthy volunteer, pulmonary function, Electrical Impedance Tomography