The Regulatory Role of Immune Response in Oral Lichen Planus

Study Overview
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Brief Summary
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Oral lichen planus (OLP) is a common chronic inflammatory disease of Oral mucosa. The pathogenesis of OLP is not clear, and there is no effective method to cure it. In vitro, previous studies have shown that oral mucosal mesenchymal stem cell cells (MSCs) can secrete Ido, which is involved in the pathogenesis of OLP. It has been proved that mental disorders such as depression and anxiety play an important role in the pathogenesis and treatment of OLP. Mental stress factors can cause abnormal changes of inflammatory factors, leading to immune dysfunction, which is also one of the main causes of OLP. In this study, we integrated the advantages of stomatology, psychiatry, neurobiology and traditional Chinese medicine, focused on the clinical problems of mental disorders with oral mucosal comorbidity, and assessed the depressive and anxiety status of OLP patients, so as to improve the therapeutic effect of OLP.

Official Title
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The Regulatory Role of Immune Response in Oral Lichen Planus With Mental Disorders

Conditions
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Oral Lichen Planus

Intervention / Treatment
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* Other: Control
* Other: Non erosive OLP
* Other: Erosive OLP


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with oral lichen planus male or female patients older than 18 years of age patients willing to participate with signed informed consent. Exclusion Criteria: pregnant or lactating had serious systemic diseases of the heart, lung, liver, and kidney, or had tumors were unwilling to participate in the experiment.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control<br>Normal control group | Other: Control<br>* Investigation of scale of control<br>|
| Non erosive OLP<br>Non erosive oral lichen planus | Other: Non erosive OLP<br>* Investigation of cale of non erosive OLP patients<br>|
| Erosive OLP<br>Erosive oral lichen planus | Other: Erosive OLP<br>* Investigation of cale of erosive OLP patients<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The scores of the scale with the symptoms and signs of the disease | Psychological factors in OLP patients and normal controls were assessed using psychological scales such as the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD). Tissue and blood samples were collected during visits, and the concentrations of inflammatory factors in normal and lesion tissues were detected using immunofluorescence, flow cytometry, and enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed to determine the correlation between emotional disorders and inflammation in OLP patients, aiming to elucidate the underlying pathogenic mechanisms. | During the initial diagnosis，through study completion, an average of 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Immune inflammatory response | Psychological factors in OLP patients and normal controls were assessed using psychological scales such as the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD). Tissue and blood samples were collected during visits, and the concentrations of inflammatory factors in normal and lesion tissues were detected using immunofluorescence, flow cytometry, and enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed to determine the correlation between emotional disorders and inflammation in OLP patients, aiming to elucidate the underlying pathogenic mechanisms. | During the initial diagnosis，through study completion, an average of 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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oral lichen planus, depression, anxiety, mesenchymal stem cells