Prevalence of Hyponatremia in Dengue Infected Patients: Relationship With Systemic Inflammation.

Study Overview
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Brief Summary
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Prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2016, and November 1, 2023. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

Detailed Description
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Background Dengue infection is becoming more prevalent worldwide and is associated with systemic inflammation. Systemic Inflammation is associated with non-osmotic release of ADH. Methods: Participants conducted a prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2016, and November 1, 2023. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

Official Title
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Prevalence of Hyponatremia in Dengue Infected Patients: Relationship With Systemic Inflammation.

Conditions
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Hyponatremia, Dengue, Inflammation

Intervention / Treatment
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* Other: hyponatremia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis confirmed by PCR, non structural protein 1 (NS1) antigen or IgM serology. Plasma sodium at admission. Exclusion Criteria: None
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| DENGUE INFECTED PATIENTS. YEAR 2016<br>We conducted a prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2016, and december 31, 2016. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L. | Other: hyponatremia<br>* hyponatremia at admission in dengue infected patients<br>|
| DENGUE INFECTED PATIENTS. YEAR 2020<br>We conducted a prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2020, and december 31, 2020. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L. | Other: hyponatremia<br>* hyponatremia at admission in dengue infected patients<br>|
| DENGUE INFECTED PATIENTS. YEAR 2023<br>We conducted a prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2023, and november 1, 2023. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L. | Other: hyponatremia<br>* hyponatremia at admission in dengue infected patients<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Admission to the hospital | Risk for admission to the hospital | between january 1, 2023 and november 1, 2023 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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DENGUE, HYPONATREMIA, INFLAMMATION