Determinants of Functional Capacity in Children With Asthma

Study Overview
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Brief Summary
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The primary aim of this study is to compare the respiratory function, respiratory muscle strength, functional capacity, and lower extremity strength of children with asthma and healthy children in the same age group. The secondary aim of our study is to determine the determinants of functional capacity in children with asthma.

Official Title
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Determinants of Functional Capacity in Children With Asthma

Conditions
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Asthma in Children

Intervention / Treatment
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* Other: 6-minute walk test
* Other: Pulmonary function test
* Other: Respiratory muscle strength test
* Other: Lower extremity muscle strength test


Participation Criteria
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Eligibility Criteria
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Asthma Group Inclusion Criteria: Being between the ages of 6-17 Being diagnosed with asthma Able to walk, cooperate and clinically stable Being a volunteer to participate in the study To be able to speak, read, understand, and cooperate in Turkish Asthma Group Exclusion Criteria: History of previous lung or liver transplant Having an acute exacerbation and/or a history of hospitalization in the last 1 month Having diagnosed orthopedic problems affecting mobility or a history of musculoskeletal surgery Control Group Inclusion Criteria: Being between the ages of 6-17 To be able to speak, read, understand, and cooperate in Turkish Being a volunteer to participate in the study Control Group Exclusion Criteria: Having a diagnosed vision, hearing, or neurological disease that may affect balance Having any other neurological, orthopedic, cardiovascular, thoracic, or metabolic disease or pathological condition that would affect assessments Resting saturation below 90% during exercise tests

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Asthma Group<br>6 minute walk test, Pulmonary function test, Respiratory muscle strength test, Lower extremity muscle strength test | Other: 6-minute walk test<br>* Functional capacity will be assessed with the 6-minute walk test (6MWT). 6MWT will be performed in accordance with the criteria of the American Thoracic Society. The 6MWT distance will be recorded in meters.<br>Other: Pulmonary function test<br>* Pulmonary function test will be performed with a spirometer (COSMED Pony FX (COSMED; Italy) by ATS/ERS criteria. Forced expiratory volume in 1 second (FEV1) and peak expiratory volume (PEF) parameters will be measured. The results will be recorded both as a percentage of measured values and expected values.<br>Other: Respiratory muscle strength test<br>* Respiratory muscle strength will be measured in accordance with ATS/ERS criteria using an electronic, mobile, (MicroRPM, Micro Medical; UK) intraoral pressure measuring device. Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) values will be recorded. Three measurements will be repeated for each maneuver and the highest value recorded as cmH2O.<br>Other: Lower extremity muscle strength test<br>* The 30-Second Chair Test is administered using a folding chair without arms, with a seat height of 17 inches (43.2 cm). The chair, with rubber tips on the legs, is placed against a wall to prevent it from moving. The participant is seated in the middle of the chair, back straight; feet approximately a shoulder width apart, and placed on the floor at an angle slightly back from the knees, with one foot slightly in front of the other to help maintain balance. Arms are crossed at the wrists and held against the chest. The participant is encouraged to complete as many full stands as possible within 30 seconds. The participant is instructed to fully sit between each stand.<br>|
| Control Group<br>6 minute walk test, Pulmonary function test, Respiratory muscle strength test, Lower extremity muscle strength test | Other: 6-minute walk test<br>* Functional capacity will be assessed with the 6-minute walk test (6MWT). 6MWT will be performed in accordance with the criteria of the American Thoracic Society. The 6MWT distance will be recorded in meters.<br>Other: Pulmonary function test<br>* Pulmonary function test will be performed with a spirometer (COSMED Pony FX (COSMED; Italy) by ATS/ERS criteria. Forced expiratory volume in 1 second (FEV1) and peak expiratory volume (PEF) parameters will be measured. The results will be recorded both as a percentage of measured values and expected values.<br>Other: Respiratory muscle strength test<br>* Respiratory muscle strength will be measured in accordance with ATS/ERS criteria using an electronic, mobile, (MicroRPM, Micro Medical; UK) intraoral pressure measuring device. Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) values will be recorded. Three measurements will be repeated for each maneuver and the highest value recorded as cmH2O.<br>Other: Lower extremity muscle strength test<br>* The 30-Second Chair Test is administered using a folding chair without arms, with a seat height of 17 inches (43.2 cm). The chair, with rubber tips on the legs, is placed against a wall to prevent it from moving. The participant is seated in the middle of the chair, back straight; feet approximately a shoulder width apart, and placed on the floor at an angle slightly back from the knees, with one foot slightly in front of the other to help maintain balance. Arms are crossed at the wrists and held against the chest. The participant is encouraged to complete as many full stands as possible within 30 seconds. The participant is instructed to fully sit between each stand.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 6-minute walk test |  | 15-20 minutes | 
| Forced expiratory volume in 1 second (FEV1) |  | 10-15 minutes | 
| Peak expiratory flow (PEF) |  | 10-15 minutes | 
| Maximal inspiratory pressure (MIP) |  | 15-20 minutes | 
| Maximal expiratory pressure (MEP) |  | 15-20 minutes | 
| Lower extremity muscle strength |  | 5-10 minutes |