Kidney and Pregnancy Registry

Study Overview
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Brief Summary
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Maternal physiological adaptation to pregnancy plays an important role in the smooth progress of the pregnancy and the healthy growth of the fetus. This physiological adaptation takes place at the level of several organs, including the kidney. Physiological changes during a normal pregnancy take place at the anatomical, glomerular and tubular level. In the event of pre-existing kidney damage (glomerular and tubular diseases, stone disease, high blood pressure (hypertension) etc...) these adaptations will not be optimal. This will have implications for: the course of the pregnancy with the occurrence of feto-maternal complications: miscarriages, pre-eclampsia, intrauterine growth retardation (IUGR), low birth weight, prematurity. The risk of feto-maternal complications increases with the degree of renal failure or with certain pathologies such as lupus. progression of kidney disease Some maternal complications have long-term implications: preeclampsia is associated with a high risk of subsequent cardiovascular and renal complications. Pregnancies in these patients are high-risk pregnancies and require specialized management by an experienced group of gynecologists and nephrologists. The creation of a retrospective and prospective register by collecting demographic, clinical, biological, radiological and genetic data concerning patients at each consultation within the CHU Brugmann Hospital will allow: to establish the epidemiological and clinico-biological characteristics of the patients followed at the Kidney and Pregnancy Clinic at the CHU Brugmann Hospital to analyze the risk factors for feto-maternal complications to analyze the risk factors for the occurrence of subsequent cardio-renal pathologies in patients who have had preeclampsia or an event during their pregnancy to identify patients who will need specialized genetic testing

Official Title
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Kidney and Pregnancy Registry

Conditions
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Kidney Diseases

Intervention / Treatment
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* Other: Data extraction from medical files


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pre-conception consultations Woman of childbearing age with: Renal damage (glomerular, tubular disease, renal lithiasis, systemic disease, metabolic diseases, congenital diseases, etc.) Hematological disorders (sickle cell disease) Kidney transplantation High blood pressure (hypertension) Pre-kidney transplant assessment in progress for discussion of contraception and pregnancy after kidney transplantation Preeclampsia Multiple miscarriages IUGR and low birth weight in the fetus Family history of kidney disease Peri-gravid consultations Pregnant women with Pre-existing kidney damage De novo renal failure (IR) Proteinuria Hematuria Chronic hypertension Pregnancy hypertension Renal lithiasis Postpartum consultations Postpartum women with Early/late pre-eclampsia Eclampsia / Hemolysis Elevated Liver enzymes Low Platelet (HELLP) syndrome Pregnancy hypertension Postpartum hemorrhage De novo renal failure postpartum Exclusion Criteria: Male patients Menopausal patients

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Kidney and Pregnancy clinic consultations<br>Patients followed at the Kidney and Pregnancy clinic pre-conception, during pregnancy and postpartum and patients subsequently referred to nephrological follow-up | Other: Data extraction from medical files<br>* Data extraction from medical files<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Epidemiological characteristics of patients |  | 20 years | 
| Clinico-biological characteristics of patients |  | 20 years | 
| Risk factors for feto-maternal complications |  | 20 years | 
| Risk factors for cardio-renal pathologies | Risk factors for the occurrence of subsequent cardio-renal pathologies in patients who had preeclampsia or an event during their pregnancy | 20 years | 
| Need for genetic testing | Identification of patients who will need specialized genetic testing | 20 years |