Oncological and Functional Outcomes in Lower Limb Osteosarcoma Pediatric Patient

Study Overview
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Brief Summary
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Retrospective analysis of specific characteristics of complications and long-term oncological and function outcomes in lower-limb osteosarcoma pediatric patients.

Detailed Description
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Clinical and functional outcomes were compared based on age groups, surgical methods, type of prosthesis, and primary tumor location. Patients were divided into the Low-age group (≤10 years old) and the High-age group (>10 years old). Overall Survival rate (OS), Progression-Free Survival rate (PFS), and prosthesis survival rate were assessed using Kaplan-Meier curves, and non-parametric survival analysis (log-rank test) was used for comparison. The incidence of complications, local relapse rate (LRR), metastasis rate, final limb-salvage and amputation rate, and Musculoskeletal Tumor Society (MSTS) score of different independent groups were further evaluated using χ2 test or Fisher's exact test, and t-test was employed to evaluate the measurement data.

Official Title
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Department of Orthopedic Oncology, The First Affiliated Hospital of Sun Yat-sen University

Conditions
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Osteosarcoma, Pediatric, Lower Limb Injury, Outcome

Intervention / Treatment
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* Other: Retrospective analysis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed lower limb osteosarcoma patients under the age of 14; Performing tumor resection treatment in our hospital; There is complete clinical registration data available. Exclusion Criteria: Not undergoing surgical treatment in our hospital; Age older than 14 years old; No available clinical registration data or lost follow-up patients; Non lower limb osteosarcoma patients.

Ages Eligible for Study
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Minimum Age: 4 Years
Maximum Age: 14 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| age groups<br>The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded. | Other: Retrospective analysis<br>* Retrospective analysis<br>|
| surgical methods<br>The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded. | Other: Retrospective analysis<br>* Retrospective analysis<br>|
| type of prosthesis<br>The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded. | Other: Retrospective analysis<br>* Retrospective analysis<br>|
| primary tumor location<br>The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded. | Other: Retrospective analysis<br>* Retrospective analysis<br>|
| Enneking stage<br>The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded. | Other: Retrospective analysis<br>* Retrospective analysis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall Survival rate (OS) | Oncological outcomes | 2000-2019 | 
| Progression-Free Survival rate (PFS) | Oncological outcomes | 2000-2019 | 
| Local recurrence rate(LRR) | Oncological outcomes | 2000-2019 | 
| Metastasis rate | Oncological outcomes | 2000-2019 | 
| Final limb-salvage and amputation rate | Oncological outcomes | 2000-2019 | 
| Prosthesis survival rate | Functional outcomes | 2000-2019 | 
| Musculoskeletal Tumor Society (MSTS) score | Functional outcomes | 2000-2019 | 
| Complications | Functional outcomes | 2000-2019 |