Interest of the Chair Lift Test in the Prognostic Evaluation of Pulmonary Embolism: a Single-center Open Prospective Study

Study Overview
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Brief Summary
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The objective of the study is to evaluate the prognostic performance of the chair lift test in the initial assessment of the severity of non-severe pulmonary embolism in hospitalized patients, in comparison with the current pulmonary embolism risk stratification score using the sPESI score refined by the use of cardiac biomarkers and right ventricular dysfunction

Official Title
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Interest of the Chair Lift Test in the Prognostic Evaluation of Pulmonary Embolism: a Single-center Open Prospective Study

Conditions
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Non-severe Pulmonary Embolism

Intervention / Treatment
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* Other: chair lift test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of pulmonary embolism according to clinical algorithm, confirmed by thoracic angioscan or ventilation perfusion (V/P) scan, Non-serious pulmonary embolism, not requiring intensive care (thrombectomy or fibrinolysis not considered). sPESI score ≥ 1 [or = 0 with elevated troponin or presence of markers of VD dysfunction, or = 0 with need for hospitalization due to comorbidities unrelated to PE (social isolation, comprehension disorders, intercurrent infection, chronic renal failure, advanced cancer...) Patients with no contraindications to chair lift testing (no O2 at the time of testing). Effective anticoagulation for at least 1 hour. Exclusion Criteria: sPESI score = 0 with outpatient referral. Diagnostic confirmation of Pulmonia Embolism by thoracic angioscan or scintigraphy more than 24h after suspicion of diagnosis. Hospitalization > 24h after introduction of anticoagulation, with subsequent confirmation by scintigraphy. Any sign of serious Pulmonia Embolism, requiring hospitalization in an intensive care unit. Asymptomatic Pulmonia Embolism discovered by chance

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: chair lift test<br> | Other: chair lift test<br>* repetitions of the sit-stand position at a self-timed speed (safe and comfortable) as many times as possible for 1 minute<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the one-minute chair rise test in comparison with the gold standard refined by the use of cardiac biomarkers and right ventricular dysfunction |  | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Troponin measurement |  | 1 day | 
| Presence or absence of post-pulmonary embolism dyspnea |  | 6 months | 
| Overall survival |  | 6 months |