Prevalence and Long Term Effects of Frailty in Elderly Intensive Care Patients

Study Overview
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Brief Summary
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The primary aim is to study change of critical frailty scale (CFS) and health related quality of life (EQ-5D-5L) in a long-term follow-up of ICU survivors. We aim to identify important ICU related predictors for change in CFS and EQ-5D-5L in long term follow up (1 yr). Secondary aim is to investigate how CFS pre-admission is related to intrahospital treatment intensity level, severity score and mortality.

Detailed Description
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This is a multi-centre norwegian observational, prospective multicenter Norway coordinated from University hospital North Norway, Tromso. The study is approved by The Regional Committee for Medical Research Ethics Northern Norway. The following scores will be assessed by asking the patient and relative during ICU stay: CFS, EQ5DL before current critical illness. The following demographic and clinical data will be retrieved from the medical records: Comorbidity before critical illness, reasons for ICU admission, daily severity score (SOFA- score), length of mechanical ventilation, dialysis, tracheostomy, Habitat before and after ICU treatment, ICU and hospital length of stay, complications retrieved during intensive care treatment, mortality, limitation of treatment. The patients will be followed up with telephone interview after hospital discharge for evaluation of: Comorbidity, CFS, EQ5DData for all sites are collected and managed using RedCap electronic data capture tools. Three research nurses will do the follow up with telephone interviews on all sites and record the data in RedCap. We aim to enroll 300 patients before 31. Des 2024.

Official Title
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Prevalence and Long Term Effects of Frailty in Elderly Intensive Care Patients

Conditions
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Frailty, Critical Illness

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: >= 65 years ≥ 24 hours mechanical ventilation Written informed consent from patient or next of kin Exclusion Criteria: Readmission of patient included in the study Not possible to obtain a valid CFS or and EQ-5D-5L at admission or follow-up of CFS because of social context or language.

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Clinical frailty score | Score from 1 to 9. | Change in Clinical Frailty score from 3 months to 12 months follow up | 
| EuroQol 5-Dimension 5-Level (EQ-5D-5L) | The scale measures quality of life on a 5-component scale | Change in EQ-5D-5L from 3 months to 12 months | 
| Mortality | Mortality during ICU-stay or subsequent 12 months. | ICU-stay or subsequent 12 months. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ICU readmission | ICU readmission rate | Long-term follow up (1 yr) | 
| ICU-LOS | ICU length of stay | Through total ICU stay, up to 3 months | 
| Treatment intensity level | ICU treatment intensity level | From inclusion in the study to discharge from intensive care unit, up to three months. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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clinical frailty scale, mechanical ventilation, elderly, EQ-5D-5L