Risk Factors And Outcomes Of Hospital Acquired AKI

Study Overview
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Brief Summary
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The aim of the study is to assess the common risk factors for development of hospital acquired acute kidney injury among hospitalized patients in Alexandria Main University hospital and their outcomes.

Detailed Description
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Hospital-acquired AKI (HAAKI) is defined as acute renal insult occurring 48 hours or more after admission to a health care facility and It is estimated to occur in 13-18% of hospitalized patients. The early diagnosis of HAAKI reflects on improvement in morbidity and mortality rates especially in developing countries which goes parallel with the goal The International Society of Nephrology (ISN) to eliminate preventable or treatable deaths from AKI by 2025, the 0 by 25 initiative. Data concerning the spectrum of acute kidney injury (AKI) in Egypt are generally scarce.

Official Title
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Risk Factors And Outcomes Of Hospital Acquired Acute Kidney Injury: A Tertiary Health Care Center Experience

Conditions
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AKI - Acute Kidney Injury

Intervention / Treatment
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* Other: standard AKI care bundle
* Other: standard care for hospitalized patients


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Fulfilment of definition of acute kidney injury according to KDIGO reference. Age more than 18 years. Exclusion Criteria: Mentally or physically unfit patients. Patients who developed acute kidney injury within 48 hours of admission to hospital.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| AKI group<br>patients who are hospitalized and develop acute kidney injury after 48 hours from admission | Other: standard AKI care bundle<br>* AKI care bundle include use of iv fluids, diuretics, antihyperkalemic drugs, sodium bicarbonate, antibiotics in septic patients.<br>|
| no AKI group<br>patients who are hospitalized and do not develop acute kidney injury after 48 hours from admission till discharge | Other: standard care for hospitalized patients<br>* this includes iv fluids, diuretics, antibiotics in septic patients, other measures according to original disease<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recovery of kidney functions | (improvement of eGFR, serum creatinine to normal or previous baseline). | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| progression to chronic kidney disease. | deterioration of kidney functions ( creatinine, eGFR) | 12 weeks | 
| mortality | death | 12 weeks | 
| Need for renal replacement therapy | different modalities of RRT | 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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AKI, Hospital Acquired, risk factors, outcomes