The Factors Causing Treatment Failure in Children Receiving Oxygen Therapy With High-flow Nasal Cannula

Study Overview
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Brief Summary
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The goal of this observational study is to identify the variables that predict treatment failure in order to identify the patients in which HFNC treatment may fail and not delay the transition to advanced respiratory support treatments in these patients. The main questions it aims to answer are: What factors contribute to the failure of HFNC treatment in these children? What is the frequency of HFNC treatment failure in children with moderate and severe respiratory distress? Researchers will compare the group whose HFNC treatment was successful with the group whose HFNC treatment failed to identify factors that cause treatment failure.

Detailed Description
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Oxygen therapy with a high-flow nasal cannula (HFNC) is a well-tolerated, relatively new, non-invasive alternative ventilation treatment modality. On the other hand, HFNC failure delays advanced respirator supportive treatments, prolongs hospitalization in the intensive care unit, and emergency department, and causes a significant increase in morbidity and mortality with hypoxemia, neurological impairment, and/or hemodynamic instability. The investigators aimed to identify the variables that predict treatment failure in order to identify the patients in which HFNC treatment may fail and not delay the transition to advanced respiratory support treatments in these patients.

Official Title
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Determination of the Factors Causing Treatment Failure in Children Receiving Oxygen Therapy With High-flow Nasal Cannula Due to Moderate and Severe Respiratory Distress

Conditions
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High-flow Nasal Cannula, Respiratory Distress, Treatment Failure

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Moderate to severe respiratory distress Oxygen therapy with high-flow nasal cannula Exclusion Criteria: Chronic lung disease (those with CO2 retention or hypoxia in their daily life) Cyanotic congenital heart disease Craniofacial malformation Trauma patients Hypotonic patients Cases with tracheostomy Patients using HFNC therapy for respiratory support after extubation

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Successful<br>Patients who do not need advanced respiratory support treatments (invasive and noninvasive mechanical ventilation) | |
| Failure<br>Patients who need advanced respiratory support treatments (invasive and noninvasive mechanical ventilation) | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HFNC treatment outcome (failure or success) | Whether advanced respiratory support treatments (invasive and noninvasive mechanical ventilation) are needed | 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pediatric, HFNC, Respiratory distress, predictor of failure