linjc16/ctgov huggingface dataset:
Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain

Study Overview
=================
Brief Summary
-----------------
The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.

Official Title
-----------------
Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain

Conditions
-----------------
Chronic Pain

Intervention / Treatment
-----------------
* Other: reward learning task


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin. For controls: matched to a case on age (±5 years) and sex Exclusion Criteria: Neurodegenerative or inflammatory neurological pathology Clinical depressive syndrome High doses of opioid treatment (greater than 100 mg/day of morphine equivalent) Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks Absolute contraindication to MRI (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cases : patients with chronic pain<br> | Other: reward learning task<br>* during usual follow-up patients will complete a remard learning task questionnaire. This questionnaire cannot be assimilated to a clinical intervention.<br>|
| controls<br> | Other: reward learning task<br>* during usual follow-up patients will complete a remard learning task questionnaire. This questionnaire cannot be assimilated to a clinical intervention.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population | the reward learning ability will be assessed using a specific task. The result of the task questionnaire is a numeric score. | Day 0 |
The Enzen Trial: Comparison of Evar Endoprosthesis: Endurant Versus Zenith

Study Overview
=================
Brief Summary
-----------------
A prospective, non-randomized trial of patients submitted to EVAR for aortoiliac aneursym using Endurant II (Medtronic) or Zenith (Cook).

Detailed Description
-----------------
A prospective, non-randomized trial of patients submitted to EVAR for aortoiliac aneursym using Endurant II (Medtronic) or Zenith (Cook). The patients will be evaluated in a follow-up, regarding overall mortality rate, perioperative mortality rate and outcomes, such as Endoleaks and reinterventions.

Official Title
-----------------
The Enzen Trial: Comparison of EVAR Outcomes With Endurant Versus Zenith Endoprosthesis: a Prospective Analysis.

Conditions
-----------------
Aortic Aneurysm, Aortoiliac Atherosclerosis

Intervention / Treatment
-----------------
* Device: EVAR


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Aortoiliac infra-renal aneurysms. - Exclusion Criteria: Thoracoabdominal aortic aneurysms, pararenal and supra-renal aortic aneurysms Patients not suitable for EVAR.

Ages Eligible for Study
-----------------
Minimum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Endurant II<br>Patients with aortoiliac aneurysm submitted to EVAR with Endurant II. | Device: EVAR<br>* Endovascular repair of aortoiliac aneurysm using Zenith or Endurant<br>|
| Zenith<br>Patients with aortoiliac aneurysm submitted to EVAR with Zenith. | Device: EVAR<br>* Endovascular repair of aortoiliac aneurysm using Zenith or Endurant<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perioperative Mortality rate | Mortality rate | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reinterventions | Reinterventions during follow-up | 2 years | 
| Endoleaks | Endoleaks during follow-up | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
aneurysm, aortic, aortic disease
Tetragraph® Monitor: Tolerance of Preoperative Placement

Study Overview
=================
Brief Summary
-----------------
This is a prospective, non-blinded, single arm study. The primary objective of this study is to evaluate the tolerance to preoperative placement of the adhesive sensor for the Tetragraph® Neuromuscular Transmission Monitor in pediatric-sized patients ≤ 12 years of age.

Official Title
-----------------
Tetragraph® Monitor: Tolerance of Preoperative Placement

Conditions
-----------------
Surgery

Intervention / Treatment
-----------------
* Device: TetraGraph NMT Monitor


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients requiring anesthetic care and use of neuromuscular blockade Age ≤ 12 years ASA 1-4 Exclusion Criteria: History of a peripheral neurologic or neuropathic disorder Upper extremity cannot be used for TOF monitoring Undergoing a surgical procedure in which neuromuscular blockade is not required Patient is edematous Patients with significant behavioral or neurocognitive issues which affect behavior and impact the ability to place the sensor

Ages Eligible for Study
-----------------
Minimum Age: 3 Months
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Tetragraph<br> | Device: TetraGraph NMT Monitor<br>* TetraGraph is a unique, EMG=based portable device for quantitative (objective) monitoring of neuromuscular function. It is a precise and easy to use tool for monitoring depth of block, ensuring adequate recovery of muscle function, and aiding the clinician to reduce the incidence of residual block.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Tolerance to preop placement as assessed by Likert scale | Patient's tolerance to preoperative placement of the adhesive sensor for the Tetragraph® Neuromuscular Transmission Monitor will be assessed by using a 10-point Likert scale with 0=very badly/pulled sensor off and 10=very well/left sensor alone. | 30 mins. prior to surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EMG changes | Changes in the amplitude of the evoked response of the muscles. | During surgery |
Feasibility of Positive Links for Youth Care Engagement Intervention

Study Overview
=================
Brief Summary
-----------------
A small pilot study to assess feasibility and acceptability of the PL4Y intervention.

Detailed Description
-----------------
After completing enrollment and informed consent, participants will be randomly assigned to PL4Y in a 2:1 fashion (intervention:control) with a target enrollment of 40 receiving the intervention and 20 in the control arm for a total of 60 participants. There is no blinding in this study protocol.

Official Title
-----------------
PL4Y: A Pilot Randomized Control Trial to Study the Feasibility of Positive Links for Youth Care Engagement Intervention

Conditions
-----------------
HIV Antibody Positivity

Intervention / Treatment
-----------------
* Behavioral: Mobile health app


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Confirmed HIV infection Recent diagnosis of HIV (within the past 6 months) OR be virologically unsuppressed (>1000 copies/ml) OR disengaged from HIV care (< 2 visits/last 12 months > 90 days apart) Exclusion Criteria: Cannot consent Unwilling to come to visits Unwilling to be in San Antonio for a year

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 29 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Participants will be randomized in a 2:1 ratio to intervention (PL4Y use) or standard of care
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Mobile Health App group<br>Mobile health app to increase rates of engagement in care in youths living with HIV | Behavioral: Mobile health app<br>* A mobile app provided to participants to assess effectiveness in managing HIV<br>* Other names: PL4Y;|
| No Intervention: Control group<br>Standard of care for youths living with HIV | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Completion of Feasibility Survey | Feasibility survey completion by participants regarding usability of the PL4Y intervention | 12 months | 
| Viral plasma load measurement | Virologic suppression is the primary goal of HIV treatment. Virologic failure is defined as a measurement over 200 copies per mL by the Department of Health and Human Services, and is the primary determinant of successful HIV control. | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Positive Links, Youth, Emerging Adults
Chinese Community Sample of Hierarchical Model of Psychopathology

Study Overview
=================
Brief Summary
-----------------
By validating Hierarchy Model of psychopathology(HiTOP) in Chinese community samples, this study aims for illumating the problem of diagnostic heterogeneity and high comorbidity within existing psychiatric classification systems in Chinese culture. Concurrently, this study also focuses on exploring trans-diagonostic risk and proctective factors underline HiTOP dimensions. the main questions it aims to answer are: Explore HiTOP model cultural differences between western culture and eastern culture. Understand the impact of different dimension of adverse childhood experience on HiTOP structure. Investigate the relationship between individual unique psychological variables and psychopathological dimensions. Participants will receive a detailed survey trying to measure their psychopathology symptoms, adverse childhood experience and psychological variables. This study expects to fallow up participants for 4 years to monitor the symptom changes.

Official Title
-----------------
Chinese Community Sample of Hierarchical Model of Psychopathology : Validation and Analysis of Underline Trans-diagnostic Risk Factors

Conditions
-----------------
Mental Health Issue, Adverse Childhood Experience

Intervention / Treatment
-----------------
* Other: No intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Chinese citizens Years of education > =9 years. age >= 18 years old. Exclusion Criteria: (1)Subjects who have insufficient self-awareness, and are unable to obtain complete informed consent, such as: schizophrenia, manic episode of bipolar disorder, severe depression.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Community sample<br>Using social media to randomly inviting participants across all regions of China. | Other: No intervention<br>* cross sectional study#no intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chinese version of Hierarchy Model of psychopathology | Constructing the Chinese version of Hierarchy Model of psychopathology. Comparing the differences between Chinese version and western version. | 1 year | 
| Mapping different dimension of adverse childhood experience on Hierarchy Model of psychopathology structure |  | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Investigate the relationship between individual unique psychological variables and psychopathological dimensions. |  | 4 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hierarchical Model of Psychopathology
Cardiovascular and Psychological Consequences of COVID-19

Study Overview
=================
Brief Summary
-----------------
The study will assess cardiac and psychological profile at 2-3 months after recovery from COVID-19 infection.

Detailed Description
-----------------
A significant proportion of patients hospitalized for COVID-19 showed laboratory signs of myocardial damage, detected by elevated troponin levels, and these were associated with more severe clinical course and higher mortality. Moreover, it is unknown how the health emergency and the associated conditions may have influenced and still influence the psychological experience of the affected people. Thus, in order to promote continuity of care, post-COVID-19 disease clinics have therefore been activated dedicated to a specific follow-up program for monitoring long-term alterations and for the early identification of patients requiring rehabilitation. The program includes a first follow-up visit (2-3 months after recovery) including cardiac (2D-echocardiography, six-minute walking test, autonomic function evaluation) and psychological (Patient Health Questionnaire-9 (PHQ-9) Generalized Anxiety Disorder-7 (GAD) National Stressful Events Survey PTSD Short Scale (NSESSS)) evaluation. A second follow-up visit will be performed at 12 months in the form of structured interview,

Official Title
-----------------
Cardiovascular and Psychological Consequences of COVID-19

Conditions
-----------------
Post-COVID Conditions

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Recent discharge (≤ 3 months) from a COVID+ ward for SARS-CoV-2 disease Exclusion Criteria: Serious clinical conditions (severe chronic inflammatory diseases, neoplasms, neurological pathologies). Non-Italian education, illiteracy, or return to illiteracy. Severe visual-perceptual deficits. Low motivation/interest or refusal to undergo the assessment.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of patients with cardiovascular or psychological sequelae |  | 3 months |
Upper Gastrointestinal Perforations: a Nationwide Registry-based Study

Study Overview
=================
Brief Summary
-----------------
The primary aim of this project is to increase the knowledge about how perforations in the esophagus, stomach and small intestine are treated on a national level. Furthermore, secondary aims include assessment of how different treatment options and type of treating facilities relate to patient survival. This will be done by studying information about all adult patients with an upper GI perforation treated in Sweden during 2005-2023.

Official Title
-----------------
Risk Factors for and Survival After Oesophageal, Gastric and Small Intestinal Perforations: a National Observational Registry-based Cohort Study

Conditions
-----------------
Acute Abdomen

Intervention / Treatment
-----------------
* Procedure: Surgical treatment type


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age of at least 18 years perforation in either oesophagus, stomach or small intestine treatment carried out in Sweden diagnosis set between January 2005 and August 2023 Exclusion Criteria: children

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Oesophageal perforation<br>Adult patients (at least 18 years of age) with an oesophageal perforation, treated for it at a Swedish hospital between 2005-2023. | Procedure: Surgical treatment type<br>* This observational design will study the clinical outcome for each type of upper gastrointestinal perforation in relation to surgical or non-surgery treatment and in relation to treatment centre.<br>|
| Gastric perforation<br>Adult patients (at least 18 years of age) with a gastric perforation, treated for it at a Swedish hospital between 2005-2023. | Procedure: Surgical treatment type<br>* This observational design will study the clinical outcome for each type of upper gastrointestinal perforation in relation to surgical or non-surgery treatment and in relation to treatment centre.<br>|
| Small intestinal perforation<br>Adult patients (at least 18 years of age) with a small intestinal perforation, treated for it at a Swedish hospital between 2005-2023. | Procedure: Surgical treatment type<br>* This observational design will study the clinical outcome for each type of upper gastrointestinal perforation in relation to surgical or non-surgery treatment and in relation to treatment centre.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | Mortality up to one year after diagnosis | One year after diagnosis | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Clinical outcomes, General surgery, Upper gastrointestinal perforation
Liver Ischemia-reperfusion Injury and Clinical Data Analysis

Study Overview
=================
Brief Summary
-----------------
Searching for new targets for the diagnosis and treatment of liver ischemia-reperfusion injury.

Detailed Description
-----------------
Through the analysis of serological data during liver resection elective surgery with hepatic pedicle occlusion and reperfusion, as well as the analysis of patient-related data, we aim to identify key target points that affect reperfusion injury and explore their underlying mechanisms.

Official Title
-----------------
Research on the Molecular Mechanisms of Liver Ischemia-reperfusion Injury and Clinical Data Analysis: an Observational Study

Conditions
-----------------
Liver Injury

Intervention / Treatment
-----------------
* Other: No intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Willingness to participate in the study and has signed an informed consent form. 2) Age ≥ 18 years and ≤ 70 years. 3) ASA classification ≤ III. 4) Criteria for liver ischemia-reperfusion injury patients: patients undergoing elective liver resection surgery with hepatic pedicle occlusion and reperfusion during the procedure. Exclusion Criteria: 1) Patients with adverse events during surgery. 2) Patients in the end stage of disease with liver failure. 3) Liver tumor metastasis with concomitant severe heart failure or chronic renal insufficiency, etc. 4) Deemed unsuitable for participation in the study based on the judgment of the researchers. -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: No intervention|No intervention|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of hospital stay | Length of hospital stay | 7days | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hepatic ischemia; Reperfusion injury