A Cohort Study of Patients With Intracranial Hemorrhage

Study Overview
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Brief Summary
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As one of the most serious forms of acute stroke, the early mortality rate of intracerebral hemorrhage(ICH) can be as high as 30-40%. The incidence of intracerebral hemorrhage increases with the increase of age. Under the circumstance of the aggravation of aging in China, intracerebral hemorrhage brings a certain burden to families and society. The results of several studies in recent years have failed to provide new therapeutic approaches for the treatment of cerebral hemorrhage. Therefore, novel therapeutic approaches is urgently needed for ICH. Primary and secondary prevention, acute inpatient care, and poststroke rehabilitation are all critical. The objective of this cohort study is to explore factors that might influence the long-term prognosis of patients with ICH and to further identify new potential targets for intervention.

Detailed Description
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The observational cohort study will be used to find the possible treatment methods and predictors of functional outcome. The medical records of patients will be collected, including age, sex, comorbid conditions, toxic habits, use of medications (antiplatelets, anticoagulants, and antihypertensives), systolic and diastolic blood pressure, Glasgow Coma Scale (GCS) score, and National Institutes of Health Stroke Scale (NIHSS) score on admission. Image data will also be collected. Follow-up information will be obtained from the medical records or telephone interviews.

Official Title
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China Cohort of Patients With Intracranial Hemorrhage

Conditions
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Intracerebral Hemorrhage

Intervention / Treatment
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* Other: Routine clinical treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Primary intracerebral hemorrhage Over 18 year-old Exclusion Criteria: Secondary intracerebral hemorrhage, such as aneurysmal, hemorrhagic transformation of ischemic stroke, cavernomas, arterio-venous malformations, central venous thrombosis, trauma-related, or tumor. Pregnant patients. Any condition which, in the judgment of the investigator, might increase the risk to the patient.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Routine clinical treatment|Routine clinical treatment is based on the latest international guidelines for intracerebral hemorrhage.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional outcome | evaluated by modified Rankin Scale | 90-day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neurological deterioration | evaluated by NIHSS or GCS | 14-day | 
| Functional outcome | evaluated by modified Rankin Scale | 1-year | 
| Cerebrovascular disease event | ischemic and hemorrhagic events | 2-year |