Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP): Focusing on Brain Health and Sleep Quality

Study Overview
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Brief Summary
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Poor sleep quality can significantly jeopardize the brain health, cognitive functions, daily activities, quality of life, and even be implicated as a key potential contributing factor in the development of accelerated cognitive decline and prodromal dementia. Consequently, research efforts to understand, and therefore potentially model, the effects of sleep quality on cognition and brain health are of great pragmatic values.

Detailed Description
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Objectives: This study aims to investigate the cognitive changes in older adults with sleep disturbances, examine the neuroimaging contributors to poor sleep quality and cognitive deficits.

Official Title
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Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP): an Observational Study on Brain Health and Sleep Quality in Community-dwelling Older Adults

Conditions
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Aging, Sleep Disturbance, Cognitive Decline, Brain Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Chinese old adults are the ones who are over 60 years of chronological age. Sleep disturbance: individual's subjective sleep quality is assessed using the Pittsburgh Sleep Quality Index (PSQI) with a total score >5. Exclusion Criteria: History of bipolar disorders or psychosis. History of major neurological deﬁcits, including stroke, transient ischemic attack or brain tumor. Unable to participant magnetic resonance imaging (MRI) scanning.

Ages Eligible for Study
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Minimum Age: 55 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Poor sleepers<br>With a total score of Pittsburgh Sleep Quality Index (PSQI) > 5. | |
| Good sleepers<br>With a total score of Pittsburgh Sleep Quality Index (PSQI) ≤ 5. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sleep quality will be measured by the Pittsburgh Sleep Quality Index (PSQI) | Pittsburgh Sleep Quality Index (PSQI) is a validated 19-item self-reported questionnaire | Baseline | 
| Global cognition will be measured by the Montreal Cognitive Assessment Hong Kong version (HK MoCA) | The Montreal Cognitive Assessment Hong Kong version (HK MoCA) is a validated and widely used screening assessment for detecting cognitive impairment, which measures an array of cognitive functions such as visuospatial, memory, language and attention. | Baseline | 
| Complex attention will be measured by the Attention Network Test (ANT) | The ANT paradigm, as a computerized test, was used and performed by E-Prime 3.0. | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Memory and learning will be measured by the Word list learning test (WLLT) | Word list learning test (WLLT), consisting of fifteen semantically non-associated words that is presented consecutively over three free trials of immediate recall, a 20-min delayed recall and followed by yes/no recognition. | Baseline | 
| Executive functions will be measured by the category verbal fluency test (CVFT) | On each trial of CVFT, the participants will be asked to overtly generate words in the animal category, fruit category and vegetable category as many as possible within 60 seconds | Baseline | 
| The levels of Aβ40 and Aβ42 will be measured by saliva analysis | saliva samples will be collected at a consistent time of day to avoid circadian effects and will be kept on ice during the collection. | Baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ageing, Sleep disturbances, Cognition, Brain health, Longevity