Intravenous Ibuprofen Postoperative Analgesia After Abdominal Hysterectomy

Study Overview
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Brief Summary
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The current research is designed to investigate the analgesic efficacy of intravenous ibuprofen on the postoperative analgesic requirements, pain intensity and other recovery parameters.

Detailed Description
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The patients will be given general anaesthesia. Anaesthesia will be induced by propofol 1-2 mg/kg, and fentanyl 1-2 µg/kg. Endotracheal intubation will be facilitated by atracurium 0.5 mg/kg. Anaesthesia will be maintained by isoflurane in oxygen - air mixture. Transversus abdominis plane block will be performed at the end of the operation. A postoperative analgesic regimen according to group allocation will be started.

Official Title
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Efficacy of Intravenous Ibuprofen in Multimodal Pain Management After Open Abdominal Hysterectomy: A Randomised Trial

Conditions
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Post Operative Analgesia

Intervention / Treatment
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* Drug: Ibuprofen


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Society of anaesthesiologists physical status I to III. Open abdominal hysterectomy operations Exclusion Criteria: History of gastrointestinal bleeding. History of intracranial haemorrhage. Pregnancy and lactation. Taking angiotensin converting enzyme(ACE) inhibitors or anticoagulation drugs. Asthmatic, hepatic,renal or heart failure. Abnormal platelet count.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: ibuprofen group<br>intravenous ibuprofen 800mg in 200 ml normal saline+IV paracetamol 1000mg+Transversus abdominis plane block | Drug: Ibuprofen<br>* 800 mg of IV ibuprofen<br>|
| No Intervention: Control group<br>200 ml normal saline+IV paracetamol1000mg+Transversus abdominis plane block | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Morphine consumption | mg | Postoperative up to 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain intensity | Visual analogue score: a score from 0 to 10( 0= no pain and 10 the worst imaginable pain) | Postoperative up to 24 hours | 
| Anaesthesia recovery time | Minutes | Perioperative | 
| Duration of post anaesthesia care unit stay | Minutes | First postoperative 24 hours | 
| Time of first ambulation | Minutes | First postoperative 24 hours | 
| Duration of hospital stay | Days | Postoperative up to 4 weeks | 
| Heart rate | Beats/minute | Perioperative | 
| Mean arterial blood pressure | mmHg | Perioperative | 
| Arterial oxygen saturation | Percentage | Perioperative | 
| End tidal carbon dioxide | mmHg | Perioperative | 
| Respiratory rate | Breath/minute | Perioperative |