Comparison of Topical 5%Potassium Hydroxide vs Liquid Nitrogen in the Treatment of Plane Warts

Study Overview
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Brief Summary
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ABSTRACT Objective: To study the efficacy while comparing Potassium hydroxide 5% with liquid nitrogen in treatment of plane warts. Study design: Randomized-controlled trial (RCT), (Double-blind). Study setting and duration: Dept dermatology, CMH-Abbottabad, Nov-2022 / April-2023. Methodology: The sample size of 60 patients (children and adults aged 4 to 30 years) was calculated using Openepi app sample size RCT calculator, after informed consent by using non-probability consecutive sampling technique. Patients randomly assigned into two groups i.e. In group-A 30 patients were given topical 5%-potassium hydroxide solution on affected area once at night upto 4 weeks and in group-B 30 patients treated with cotton bud method of cryotherapy with liquid nitrogen once every two weeks. Patients were reassessed at every two weeks and final assessment was done at 12th week whereas followed up for 3 months to monitor recurrence. Demographic information and frequency percentages were calculated for qualitative variables by using SPSS26. To determine statistical significance taking p-value <0.05 as significant, and χ2-square test was used.

Official Title
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Comparative Efficacy of Topical 5%Potassium Hydroxide vs Liquid Nitrogen in the Treatment of Plane Warts

Conditions
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Plan Warts

Intervention / Treatment
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* Drug: 5%potassium hydroxide
* Drug: Liquid nitrogen


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 4-30 years Both males and females Greater than 3 number of warts Exclusion Criteria: Pregnancy Breast feeding Those who are taking immunosupressive drugs

Ages Eligible for Study
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Minimum Age: 4 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Group A Topical 5% potassium hydroxide<br>In group-A 30 patients were given topical 5%-potassium hydroxide solution on affected area once at night upto 4 weeks | Drug: 5%potassium hydroxide<br>* . In group-A 30 patients were given topical 5% potassium hydroxide solution on affected area once at night for upto 4 weeks<br>|
| Active Comparator: Group B Liquid nitrogen<br>in group-B 30 patients treated with cotton bud method of cryotherapy with liquid nitrogen once every two weeks. Patients were reassessed at every two weeks and final assessment was done at 12th week. | Drug: Liquid nitrogen<br>* in group-B 30 patients treated with cotton bud method of cryotherapy with liquid nitrogen once every two weeks. Patients were reassessed at every two weeks. The treatment carried out upto 12 weeks or until complete recovery from warts.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparative Efficacy of topical 5% Potassium hydroxide and liquid nitrogen in the treatment of plane warts | Decrease in number or size of warts | 12 weeks |