EXerCise wEight Loss

Study Overview
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Brief Summary
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The overall aim of this study is to investigate the effects of home-based resistance exercise programme on changes in body composition and strength during weight loss, in people living with obesity or overweight.

Official Title
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The Effects of a Home-based Resistance Training Programme on Body Composition and Muscle Function During Weight Loss in People With Overweight or Obesity: a Randomised Controlled Pilot Trial

Conditions
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Overweight and Obesity

Intervention / Treatment
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* Behavioral: Resistance exercise training + weight loss group
* Behavioral: Weight loss only group (WL)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Obesity or overweight (BMI ≥ 25kg/m2). Passing the Physical Activity Readiness Questionnaire (PAR-q+) Exclusion Criteria: Currently take part in more than 1.5 hours of structured exercise per week. Having recently (<6 months) taken part in any resistance exercise training, taking any medications known to affect weight loss. Actively engaged in a weight loss programme, having lost more than 2kg weight in the last 6 months. Any other reason which would limit ability to perform the exercises and outcome measurements safely.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Randomised controlled pilot trial with two groups, resistance exercise + weight loss group and weight loss only group.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Resistance exercise training + weight loss group (RT+WL)<br>Participants (WL-RT) will be provided with a resistance exercise booklet containing instructions for exercises and links to demonstration videos. A demonstration and explanation of the exercises will be given at the beginning of the intervention, alongside a discussion of the principles of the programme such as starting level and progression. We will ask participants to perform the resistance exercises for 12-week period. Participants will be asked to perform exercises 3 times a week (3 sets reaching the RPE scale between 8 - 10 out of 10 (4-6 out of 10 in the first week)) for the intervention period. The exercises will include press-ups, band lateral raises, band seated low row, squat, lunge and calf raise. | Behavioral: Resistance exercise training + weight loss group<br>* Doing resistance exercises as well as following the weight watchers weight loss programme for a 12-week period<br>|
| Experimental: Weight loss only group (WL)<br>All participants (WL and WL-RT) will be provided with vouchers to access the weight watchers weight loss programme for a 12-week period. Weight Watchers is a commercially available programme and participants will set an initial goal to lose 5kg of body mass. If 5kg weight loss is achieved then the participant can chose further weight loss goals, as long as it would result in a body mass in the weight watchers healthy weight range (https://www.weightwatchers.com/uk/weight-loss/programme/tools/healthy-weight-chart).This plan works on the basis of an individualised points plan that can then be used by the participant to select foods/meals to consume throughout the day. | Behavioral: Weight loss only group (WL)<br>* Only following the weight watchers weight loss programme for a 12-week period<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in whole body lean mass | whole body lean mass measured via bio-electrical impedance | Change from baseline to 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in whole body fat mass | whole body fat mass measured via bio-electrical impedance | Change from baseline to 12 weeks | 
| Change in body mass | body mass measured on scales | Change from baseline to 12 weeks | 
| Change in vastus lateralis muscle thickness | Muscle thickness of the vastus lateralis muscle measured via ultrasound | Change from baseline to 12 weeks | 
| Change in knee extensor maximal isometric torque | Knee extensor maximal isometric torque measured during a maximal voluntary contraction | Change from baseline to 12 weeks | 
| Change in grip strength | Grip strength measured with a hand held dynamometer | Change from baseline to 12 weeks | 
| Change in functional physical abilities | A 30-second sit-to-stand test measured functional abilities | Change from baseline to 12 weeks |