Efficacy of Repetitive Transcranial Magnetic Stimulation in Adult Attention Deficit Disorder

Study Overview
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Brief Summary
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The purpose of the current open-lable study was to use low-frequency repetitive transcranial magnetic stimulation (rTMS) to improve the attention deficits in a sample of adult patients suffering from attention deficit disorder. Participants received 10 sessions of rTMS over Fz (located using the EEG 10-20 international system) and underwent assessments of their attentional capacity using the gradCPT task in an fMRI scanner, before and after the intervention. Other behavioral assessments of their attention symptoms have also been conducted.

Official Title
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An Open-lable Investigation of the Effect of rTMS on Attention in an Adult Sample Suffering From ADD

Conditions
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Attention Deficit Disorder, ADHD

Intervention / Treatment
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* Device: repetitive Transcranial Magnetic Stimulation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Normal intelligence level (>90) Diagnosis of ADD by a psychiatrist using the ADHD-RS-IV with Adult Prompts Exclusion Criteria: Scores of 21 or more on BDI and/or BAI History of head trauma History of a major psychological or neurological condition Presence of metal in the head History of seizures Serious cardiovascular disease Use of medications with an impact on cognitive functions during the treatment window (patients with a constant and stable dose were included) Recent use of alcohol or substance abuse

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Active rTMS<br>Participants in this one and only arm in the current study received active repetitive transcranial magnetic stimulation. | Device: repetitive Transcranial Magnetic Stimulation<br>* Magnetic pulses delivered to the Fz area of the brain in a low frequency (1 Hz) manner.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in performance | Shortened version (4 min) of the continuous go/no-go task: gradual-onset continuous performance task (gradCPT) | Up to 10 days, i.e., before and after the completion of the 10 sessions of rTMS | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in self-report attention scores | The 6-item ASRS-V1.1 Adult ADHD Self-Report | Baseline, after 5 days of stimulation, after 10 days of stimulation; Range= 0-6; Higher scores represent worse outcome | 
| Change in investigator-rated attention scores | Investigator-Rated Attention-Deficit Hyperactivity Disorder (ADHD) Rating Scale-IV (I-ADHD RS-IV) with adult prompts | Baseline, after 5 days of stimulation, after 10 days of stimulation; Range:0 - 54; Higher scores represent worse outcome | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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rTMS, ADHD, ADD, fMRI