Anaerobic Exercise and Mental Acuity

Study Overview
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Brief Summary
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This is a randomized controlled trial to examine the effect of anaerobic activity (e.g., weight training) on gut microbiome metabolism and neurological health in healthy sedentary men.

Detailed Description
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The human gut microbiome, which houses over 2,000 distinct bacterial species, has recently been characterized as a highly influential force on the health and longevity of its host. By way of several distinct pathways comprising the microbiome-gut-brain axis, this diverse population is known to communicate with the human brain in a bidirectional manner and is implicated in the pathophysiology of several metabolic and psychological disease states. The ability to support a healthy, diverse microbiome through modifiable behavioral interventions - such as diet and exercise - is a topic of growing interest. Most of the evidence pertaining to the relationship between physical activity and the gut-brain axis at this time, however, investigates the influence of aerobic exercise providing limited insight to how other modalities of physical activity may differ. Specifically, this study will examine the impact of an 8-week weight training protocol on gut microbiome metabolism and neurological health in healthy sedentary men. Participants will be randomly assigned to the intervention group or the waitlist control group.

Official Title
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Anaerobic Exercise as a Modulator of Microbial Composition and Mental Acuity in Sedentary Men

Conditions
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Depression, LPS, Mood

Intervention / Treatment
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* Other: weight training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: free of any existing medical diagnoses willing and able to participate in moderate to vigorous exercise as determined by the ACSM Health/Fitness Facility Preparticipation Screening Questionnaire sedentary (defined as a score <14 on the Godin-Shepard Leisure Time Physical Activity Questionnaire (GSLTQ)) equipped with access to a complete gym Exclusion Criteria: antibiotic use within the past six months prebiotic, probiotic, or high-dose antioxidant supplementation within the past 6 months smoker (cigarettes and/or marijuana) regular laxative use blood pressure >129/80 at baseline

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: randomized controlled trial (waitlist control)
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: weight training<br>A prescribed 8-week training protocol | Other: weight training<br>* weight training<br>|
| No Intervention: no prescribed weight training<br>no prescribed weight training | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| gut barrier integrity | serum LPS binding protein | change from baseline at week 8 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mood state | Depression score on Center for Epidemiological Studies-Depression (CES-D) questionnaire. Scores range from 0-60, with scores >15 indicating an elevated risk of depression and scores >30 indicating elevated symptoms of depression that may influence the health of the individual | change from baseline at week 8 |