Krill Oil and Resistance Exercise in Older Adults

Study Overview
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Brief Summary
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The aim of this study is to determine whether krill oil supplementation enhances effects of a pragmatic resistance exercise programme on adaptations in muscle strength, mass, function and neuromuscular function in sedentary older adults. Hypothesis - krill oil supplementation will enhance the beneficial effects of resistance exercise on muscle strength, function, mass and neuromuscular function in sedentary older adults.

Official Title
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The Effects of Krill Oil Supplementation on Adaptations in Muscle Strength, Function, Mass and Neuromuscular Function to a Pragmatic Home-based Resistance Exercise Intervention in Sedentary Older Adults: a Randomised Controlled Trial

Conditions
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Sarcopenia

Intervention / Treatment
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* Dietary Supplement: Vegetable oil
* Dietary Supplement: Krill oil
* Other: Home-based resistance exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Over the age of 60 years scoring a low level of physical activity based on international physical activity questionnaire (not meeting the recommend physical activity which is at least 600 MET-min per week). Exclusion Criteria: Diabetes severe cardiovascular disease seizure disorders uncontrolled hypertension (>150/90mmHg at baseline measurement) cancer or cancer that has been in remission <5 years ambulatory impairments which would limit ability to perform assessments of muscle function dementia taking medication known to affect muscle (e.g. steroids) have an implanted electronic device (e.g. pacemaker/defibrillator/insulin pump) on anticoagulant therapy allergies to seafood regular consumption of more than 1 portion of oily fish per week already taking fish or krill oil or other n3 PUFA supplements femoral neck fracture or other severe of hip or knee operations stroke Parkinson's disease COPD kidney disease hyperlipidaemia obesity osteoporosis.

Ages Eligible for Study
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Minimum Age: 60 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: 1:1 parallel group design
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Vegetable oil + Resistance exercise<br>4g/day vegetable oil and home based resistance exercise for 16 weeks | Dietary Supplement: Vegetable oil<br>* Mixed vegetable oil<br>Other: Home-based resistance exercise<br>* Home based resistance band and body weight exercise<br>|
| Active Comparator: Krill oil + Resistance exercise<br>4g/day krill oil and home based resistance exercise for 16 weeks | Dietary Supplement: Krill oil<br>* Superba Krill Oil<br>Other: Home-based resistance exercise<br>* Home based resistance band and body weight exercise<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nueromuscular Junction (NMJ) transmission instability | NMJ transmission instability will be measured by iEMG | Change from baseline to 16 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Knee extensor maximal torque | Knee extensor maximal torque will be measured by a load cell | Change from baseline to 8 16 weeks | 
| 30s chair stand test | measuring the functional abilities | Change from baseline to 16 weeks | 
| Gait speed | measuring the functional abilities | Change from baseline to 16 weeks | 
| Force steadiness during submaximal isometric knee extensor contractions | Steadiness of force whilst contracting | Change from baseline to 16 weeks | 
| Red Blood Cell Omega-3 levels |  | Change from baseline to 16 weeks | 
| Grip strength | Grip strength will be measured by handgrip dynamometer | Change from baseline to 16 weeks | 
| Muscle thickness | Vastus Lateralis muscle thickness will be measured by ultrasound | Change from baseline to 16 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Home exercise, Resistance exercise, Exercise, Krill oil, Muscle strength, Neuromuscular function, Physical function