Evaluate the Role of Soleus Muscle Exercise in Glycaemic Control in Diabetic Kidney Disease Patients

Study Overview
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Brief Summary
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Evaluate the role of Soleus muscle exercise in management diabetic kidney disease

Detailed Description
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management of diabetic kidney disease. To enhance their glycemic control, diabetic patients are advised to perform 150 minutes per week of moderate-to-vigorous aerobic activity Diabetic patients with regular physical activity have reduced daily insulin dose with more glycemic control. In addition to glycemic control, it has also been postulated that the addition of brief intervals of high intensity, sprint -type exercise to aerobic exercise can decrease the risk of late nocturnal hypoglycemic episodes Marc T. Hamilton et al., 2022, reported that the human soleus muscle could raise local oxidative metabolism to high levels for hours without fatigue, during a type of soleus-dominant activity while sitting (soleus push up exercise), even in unfit volunteers. They reported that soleus push up exercise can improve systemic VLDL-triglyceride and glucose homeostasis by a large magnitude, e.g., 52% less postprandial glucose excursion (∼50 mg/dL less between ∼1 and 2 h) with 60% less hyperinsulinemia. Muscle biopsies revealed there was minimal glycogen use. This can be explained that the soleus doesn't rely completely on intramuscular glycogen, Instead, it uses a mixture of fuels from glucose and lipoproteins.

Official Title
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Evaluate the Role of Soleus Muscle Exercise in Glycaemic Control in Diabetic Kidney Disease Patients

Conditions
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Diabetic Kidney Disease

Intervention / Treatment
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* Device: Soleus ms exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients age 18-60 yrs., patients with Diabetic kidney disease, not on dialysis with stabilized diabetic treatment regimen for 3 months before participating in the study Exclusion Criteria: advanced osteoarthritis of lower limb joints advanced poly neuropathic patients CKD type V on dialysis Diabetic Foot hemophilia bleeding tendency AKI other causes of chronic kidney disease patients refuse to participate in the study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Soleus muscle exercise in diabetes<br>Soleus muscle decrease blood glucose | Device: Soleus ms exercise<br>* Soleus muscle exercise before and after eating by half an hour<br>|
| Experimental: Decrease glucose level by soleus exercise<br>Soleus ms exercise in decrease blood glucose | Device: Soleus ms exercise<br>* Soleus muscle exercise before and after eating by half an hour<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| HbA1C less than 7% | Improve HbA1c by soleus muscle exercise | One year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ratio of albumin (mcg/L) to creatinine (mg/L)ratio | Improve alb /creatinine ratio | One year |