BMAC Loaded Collagen Jumping the Gap Around Immediate Implants

Study Overview
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Brief Summary
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The present study aims to evaluate the effect of utilization of BMAC/ collagen on marginal bone changes around immediate implants in the esthetic zone of maxilla. Methodology: Twenty dental implants will be installed in the esthetic zone and patients will be randomly divided into two groups: study group: The jumping gap surrounding the immediate implants will be grafted with BMAC/collagen, whereas in the control group, autograft from the chin will be used to fill the defect. Cone beam CT (CBCT) will be requested Preoperative, immediate and 4 months Postoperative for assessment of marginal bone changes around implants. .

Detailed Description
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The aim of present study is to evaluate the effect of utilization of bone marrow aspirate concentrate (BMAC) loaded on collagen on the marginal bone changes around immediate implants in the esthetic zone of maxilla. Methodology: Twenty dental implants will be installed in patients suffering from non- restorable teeth in esthetic zone. Patients will be randomly divided into two equal groups: study group: The jumping gap surrounding the immediate implants will be grafted with bone marrow aspirate concentrate loaded on collagen, whereas in the control group, autogenous bone graft from the chin will be used to fill the peri-implant defect. CBCT will be requested Preoperative, immediate and 4 months Postoperative for assessment of marginal bone changes around dental implants. .

Official Title
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Assessment of Collagen Loaded With Bone Marrow Aspirate Concentrate Versus Autograft on Marginal Bone Changes Around Immediate Implants in Esthetic Zone. A Randomized Controlled Clinical Trial

Conditions
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Implant Site Reaction, Dental Implantation

Intervention / Treatment
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* Drug: BMAC/ collagen
* Procedure: Autograft harvesting from chin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with non- restorable teeth in esthetic zone Patients above 18 us Highly motivated patients. Exclusion Criteria: patients with systemic diseases • immunocompromised patients . Patients with bleeding disorders

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: BMAC/ collagen<br>Bone marrow aspirate concentrate loaded on collagen utilization for filling peri-implant gap around immediate dental implants in the Maxillary esthetic zone | Drug: BMAC/ collagen<br>* Bone marrow aspirate concentrate loaded on collagen in the peri-implant defect<br>* Other names: Bone marrow aspirate concentrate group;|
| Active Comparator: Autograft<br>Autograft harvested from chin utilization for filling peri-implant gap around immediate dental implants in the Maxillary esthetic zone | Procedure: Autograft harvesting from chin<br>* Autograft<br>* Other names: Autograft group;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Marginal bone changes | Buccal bone height | 4 months |