Measurement of Antioxidant Activity on Postoperative Inflammation in Patients Undergoing Ophthalmic Surgery

Study Overview
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Brief Summary
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This trial hypothesized that novel laser refractive surgery techniques (PRK, LASIK, SMILE) or laser-assisted cataract surgery (FLACAS) could suppress postoperative inflammation and improve recovery in patients by reducing oxidative stress generated by the surgical procedure. It is also intended to verify whether the new laser technology is necessary for clinical use in groups with low antioxidant activity through the detection of antioxidant activity in the eyes of patients.

Official Title
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Effects of Laser Species and Ocular Antioxidant Activity on Postoperative Inflammation and Visual Prognosis in Patients Undergoing Ophthalmic Surgery - a Comparative Study

Conditions
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Cataract, Myopia

Intervention / Treatment
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* Procedure: Cataract surgery, Femtosecond-LASIK, SMILE


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: over 20 years old (included) corneal refractive surgery or cataract surgery patients Exclusion Criteria: patients with eye infections presence of severe retinal disease presence of severe eye injury or severe ptosis

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Cataract surgery, Femtosecond-LASIK, SMILE|Cataract surgery includes both conventional and femtosecond laser assisted. Femtosecond-LASIK and SMILE are options for patients to correct myopia.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of Total Antioxidant Capacity (TAC) in tears from Baseline to 1 week after surgery. |  | Before the operation and 1 week after surgery. | 
| Change of Total Antioxidant Capacity (TAC) in tears from Baseline to 1 month after surgery. |  | Before the operation and 1 month after surgery. | 
| Change of Total Antioxidant Capacity (TAC) in tears from Baseline to 3 months after surgery. |  | Before the operation and 3 months after surgery. | 
| Change of Total Antioxidant Capacity (TAC) in tears from Baseline to 6 months after surgery. |  | Before the operation and 6 months after surgery. | 
| Change of Ascorbic Acid (AA) in tears from Baseline to 1 week after surgery. |  | Before the operation and 1 week after surgery. | 
| Change of Ascorbic Acid (AA) in tears from Baseline to 1 month after surgery. |  | Before the operation and 1 month after surgery. | 
| Change of Ascorbic Acid (AA) in tears from Baseline to 3 months after surgery. |  | Before the operation and 3 months after surgery. | 
| Change of Ascorbic Acid (AA) in tears from Baseline to 6 months after surgery. |  | Before the operation and 6 months after surgery. | 
| Change of Total Antioxidant Capacity (TAC) in aqueous humor from Baseline to one day after surgery. |  | During the operation and one day after surgery. | 
| Change of Ascorbic Acid (AA) in aqueous humor from Baseline to one day after surgery. |  | During the operation and one day after surgery. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Examination of best corrected visual acuity (BCVA). |  | Before the operation. | 
| Examination of uncorrected visual acuity (UCVA). |  | Before the operation. | 
| Examination of uncorrected visual acuity (UCVA). |  | One week after surgery. | 
| Examination of uncorrected visual acuity (UCVA). |  | One month after surgery. | 
| Examination of intraocular pressure (IOP). |  | Before the operation. | 
| Examination of intraocular pressure (IOP). |  | One week after surgery. | 
| Examination of intraocular pressure (IOP). |  | One month after surgery. | 
| Examination of central corneal thickness (CCT). |  | Before the operation. | 
| Examination of central corneal thickness (CCT). |  | One week after surgery. | 
| Examination of central corneal thickness (CCT). |  | One month after surgery. | 
| Examination of axial length (AXL). |  | Before the operation. | 
| Examination of anterior chamber depth (ACD). |  | Before the operation. | 
| Examination of lens thickness (LT). |  | Before the operation. | 
| Examination of manifest refraction. |  | Before the operation. | 
| Examination of manifest refraction. |  | One week after surgery. | 
| Examination of manifest refraction. |  | One month after surgery. | 
| Examination of corneal curvature. |  | Before the operation. | 
| Examination of corneal curvature. |  | One week after surgery. | 
| Examination of corneal curvature. |  | One month after surgery. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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antioxidants