Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder

Study Overview
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Brief Summary
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This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.

Official Title
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Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-compulsive Disorder: Towards Personalization of Patient Care

Conditions
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OCD

Intervention / Treatment
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* Other: Functional MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions) Understand and accept the constraints of the study Be a beneficiary or affiliated to a Health Insurance scheme Exclusion Criteria: Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998) Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998) Have a serious intercurrent pathology Being a pregnant woman Being a woman of childbearing age without effective contraception. Being hospitalized under duress or on an outpatient basis in a care program Being under judicial protection (reinforced curatorship, guardianship)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| obsessive compulsive disorder patients<br> | Other: Functional MRI<br>* Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task<br>|
| Control Patients<br> | Other: Functional MRI<br>* Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cerebral activity modification during N-back task | Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls | Day 1 | 
| Cerebral activity modification during Stroop task | Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls | Day 1 | 
| Cerebral activity modification during switching task (Monsell et Mizon task ) | Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls | Day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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functional MRI