linjc16/ctgov huggingface dataset:
Public Survey on Breath Testing for Health and Disease

Study Overview
=================
Brief Summary
-----------------
A brief survey for the public to determine interest in health surveillance and disease detection

Detailed Description
-----------------
There are numerous barriers and favourable conditions that affect the acceptability of a screening test for cancer. Such factors have been investigated in the context of some of the current screening programs. Through this survey the investigators want to increase researcher awareness of these factors with the hope that this information will aid policy makers and guide future research. There has been widening public interest in general health-surveillance in addition to disease detection. Breath testing has the potential to be a one-for-all non-invasive test to detect health domains. Through this survey, the investigators wish to understand public opinions about breath testing for health. This survey consists of questions aiming to gather views on non-invasive testing for health and disease.

Official Title
-----------------
Public Survey on Breath Testing for Health and Disease

Conditions
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Cancer, Disease, Health Behavior, Health Attitude, Health-Related Behavior, Health Knowledge, Attitudes, Practice

Intervention / Treatment
-----------------
* Behavioral: Survey


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: Member of the public above the age of 18 Exclusion Criteria: Member of the public below the age of 18

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Public<br>General public to be approached to answer this survey via GPs, charities and exhibitions such as Great Exhibition Road Festival. | Behavioral: Survey<br>* Members of the public will be asked to complete a survey that collects information on individuals perception of health and disease and their views on breath testing.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acceptability of breath testing | Proportion of people that find breath testing an acceptable means to determine health or disease | 6 months |
Incidence of Cholelithiasis After Bariatric Surgery in Sohag University Hospital

Study Overview
=================
Brief Summary
-----------------
To study the incidence and predictors of developing symptomatic gallstone disease following bariatric surgery.

Detailed Description
-----------------
To study the incidence and predictors of developing symptomatic gallstone disease following bariatric surgery. A retrospective study with prospective collective data will be conducted including all patients underwent bariatric surgery in general surgical department, Sohag University between January 2015 and December 2022 who did not have gallstones in the preoperative abdominal ultrasound examinations. Medical records will be reviewed. Demographic data such as age, gender, BMI, comorbidities as ( DM, hypertension and hyperlipidemia ) and time elapsed between the surgery to post-surgery US examination. The findings of the US examinations will be collected and analyzed. Data will be analyzed to obtain descriptive and inferential statistics.

Official Title
-----------------
Incidence of Cholelithiasis After Bariatric Surgery in Sohag University Hospital

Conditions
-----------------
Cholelithiasis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All adult patients underwent bariatric surgery with minimum postoperative follow up period of one year duration will be included in the study. Exclusion Criteria: Patients who had cholecystectomy during the bariatric surgery. Pediatric age.
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients who developed gall stones<br> | |
| patients who did not develope gall stones<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients who develop gall bladder stones after bariatric surgery | Evalution of gall bladder stone formation postoperaive and its relation with comorbidities | one year |
Investigation of Preoperative Frailty in Elderly Patients With Colorectal Cancer and Correlation Between Preoperative Frailty and Early Postoperative Prognosis

Study Overview
=================
Brief Summary
-----------------
To investigate and analyze the status of preoperative frailty and its influencing factors in elderly patients with colorectal cancer using FRALL scale and other related scales, and to explore the correlation between preoperative frailty and early prognosis in elderly patients with colorectal cancer, so as to attract the attention of medical staff to preoperative frailty in this population and provide a preliminary research basis for the study of frailty intervention in these patients.

Official Title
-----------------
Investigation of Preoperative Frailty in Elderly Patients With Colorectal Cancer and Correlation Between Preoperative Frailty and Early Postoperative Prognosis

Conditions
-----------------
Colorectal Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age ≥60 years old; Colorectal cancer was diagnosed according to the Chinese Guidelines for Diagnosis and Treatment of Colorectal Cancer (2020 edition) and planned to undergo elective laparoscopic radical resection of colorectal cancer; able to complete physical assessment without communication barriers; voluntarily participated in this study after informed consent. Exclusion Criteria: taking antidepressants, levodopa, donepezil hydrochloride and other drugs; patients with preoperative colorectal cancer surgery or neoadjuvant therapy; patients with TNM stage Ⅳ; complicated with other malignant tumors except primary skin cancer or melanoma.

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fatigue Assessment | Status of frailty will be assessed by FRALL Scale | 7 days |
In-depth ECG Analysis for the Extraction of Biomarkers of Cardiac Mechanical Dispersion

Study Overview
=================
Brief Summary
-----------------
Left ventricular systolic dysfunction (LVSD) refers to impaired contraction of the left ventricle, and can lead to heart failure and death. Early identification of LVSD, which often remains asymptomatic for years, is therefore crucial to mitigate the associated risks through appropriate treatment. Echocardiographic screening of asymptomatic individuals is costly, requires access to experts, and the criteria for selecting potential high-risk individuals for screening remain unclear. Unlike echocardiography, the electrocardiogram (ECG) is a relatively low-cost procedure, routinely available and requiring little technical training to set up the examination and collect data, making it an interesting tool for early detection of LVSD.

Official Title
-----------------
In-depth ECG Analysis for the Extraction of Biomarkers of Cardiac Mechanical Dispersion

Conditions
-----------------
Cardiovascular Pathology

Intervention / Treatment
-----------------
* Device: ECG
* Device: Echocardiography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Person who has received full information on the organization of the research and has not objected to the use of this data; Age ≥ 50; Persons who have undergone an echocardiographic examination and a 12-lead ECG examination during consultations at the CHRU de Nancy; Persons with at least one cardiovascular risk (obesity, diabetes, hypertension, etc.). Exclusion Criteria: People with a history of heart disease (ischemic, valvular); Patients with significant 12-lead ECG abnormalities (complete bundle branch block, sequelae of myocardial infarction, etc.); ECG tracings or echocardiograms that cannot be analyzed.

Ages Eligible for Study
-----------------
Minimum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No myocardial contractility abnormalities<br> | Device: ECG<br>* Routine care 12-lead electrocardiogram<br>Device: Echocardiography<br>* Routine care echocardiography<br>|
| Myocardial contractility abnormalities<br> | Device: ECG<br>* Routine care 12-lead electrocardiogram<br>Device: Echocardiography<br>* Routine care echocardiography<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| F1 score for classification of cardiac contractility abnormalities |  | 12 months |
Indocyanine Green-guided Lymphadenectomy in Laparoscopic Total Mesorectal Excision for Low Rectal Cancer After Neoadjuvant Chemoradiotherapy

Study Overview
=================
Brief Summary
-----------------
The goal of this clinical trial is to assess the number of harvested locoregional lymph nodes in rectal cancer patients undergoing laparoscopic total mesorectal excision and indocyanine green (ICG)-guided lymphoadenectomy after neoadjuvant chemoradiation. The main questions it aims to answer are: Does the use of ICG increase the total number of harvested lymph nodes? Does the use of ICG increase the number of harvested extra-mesorectal lymph nodes? Participants will intraoperatively receive a trans-anal administration of ICG near to rectal cancer; during laparoscopic surgery, ICG-fluorescent nodes beyond the mesorectum will be separately excised and sent for pathology. A comparison will be performed with a recent cohort of patients affected by rectal cancer treated with standard surgery without the use of ICG.

Official Title
-----------------
Indocyanine Green-guided Lymphadenectomy in Laparoscopic Total Mesorectal Excision for Low Rectal Cancer After Neoadjuvant Chemoradiotherapy

Conditions
-----------------
Rectal Cancer, Lymph Node Cancer Metastatic

Intervention / Treatment
-----------------
* Procedure: ICG-guided lymphadenectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Low or middle rectal adenocarcinoma Indication for sphincter-saving surgery Neoadjuvant chemoradiation Indication for laparoscopic surgery Signed informed consent Exclusion Criteria: Distant metastases at diagnosis, included peritoneal carcinomatosis Squamous cell cancer Allergy to indocyanine green

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: ICG-guided lymphadenectomy<br>Patients will intraoperatively receive a transanal local administration of ICG. During laparoscopic total mesorectal excision, ICG-fluorescent lymph nodes beyond the mesorectum will be separately excised and sent for pathology | Procedure: ICG-guided lymphadenectomy<br>* Excision of ICG-fluorescent lymph nodes in addition to standard laparoscopic total mesorectal excision in rectal cancer patients after neoadjuvant chemoradiation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total number of harvested lymph nodes |  | 15 days | 
| Number of harvested extra-mesorectal lymph nodes |  | 15 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraoperative and postoperative complications rates |  | 15 days | 
| Time of surgery |  | 15 days |
Engineering Immune Organoids to Study Pediatric Cancer

Study Overview
=================
Brief Summary
-----------------
To engineer immune organoids from pediatric patient tissues using induced-pluripotent stem cells (iPSC)

Official Title
-----------------
Engineering Immune Organoids to Study Pediatric Cancer (IMMUNE-ORGANOIDS)

Conditions
-----------------
Sarcoma, Neuroblastoma, Brain Tumor, Kidney Tumor

Intervention / Treatment
-----------------
* Procedure: Skin biopsy
* Procedure: Fresh tumor sample
* Biological: Blood sample
* Procedure: Healthy tissue from the tumor
* Procedure: Spinal cerebrospinal fluid (SCF)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age at diagnosis ≤ 25 years except for patients with malignant gliomas and renal tumors for whom no upper age limit is applied Medical suspicion or diagnosis of one of the following diseases, regardless of stage: Brain tumors Renal tumors Neuroblastoma Sarcomas Adult patient or parents or guardians should understand, sign and date the appropriate written informed consent from prior to any protocol-specific procedures performed. Patient should be able and willing to comply with study visits and procedures as per protocol. Affiliated to a social security system or beneficiary of the same. Exclusion Criteria: Any histology not mentioned in the inclusion criteria Adult patient or parents/guardians incapable/incapable of giving its/their consent Patients deprived of their liberty by a judicial or administrative decision

Ages Eligible for Study
-----------------
Maximum Age: 25 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Immune organoids from pediatric patient tissues using iPSC<br>To engineer immune organoids from pediatric patient tissues using induced-pluripotent stem cells (iPSC) | Procedure: Skin biopsy<br>* Skin biopsy<br>Procedure: Fresh tumor sample<br>* Fresh tumor sample<br>Biological: Blood sample<br>* Blood sample in heparin tubes (highly recommended), to be collected before starting treatment or as soon as hematological recovery has been reached<br>Procedure: Healthy tissue from the tumor<br>* Healthy tissue from the tumor site whenever possible<br>Procedure: Spinal cerebrospinal fluid (SCF)<br>* Spinal cerebrospinal fluid (SCF) whenever possible<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of viable and exploitable immune organoids with engrafted tumor cells |  | until 5 years after enrolment |
Spontaneous Evisceration of Infantile Umbilical Hernia

Study Overview
=================
Brief Summary
-----------------
Infantile umbilical hernia is common in children. It has a regressive course in most cases. Conservative management is the standard in most cases before the age of 3 years unless there are complications such as incarceration, rupture with evisceration which are extremely rare and warrants emergency surgery. We present a rare case of a 6-month-old child with sudden spontaneous evisceration of infantile umbilical hernia.

Detailed Description
-----------------
Infantile umbilical hernia is common in children. It has a regressive course in most cases. Conservative management is the standard in most cases before the age of 3 years unless there are complications such as incarceration, rupture with evisceration which are extremely rare and warrants emergency surgery. We present a rare case of a 6-month-old child with sudden spontaneous evisceration of infantile umbilical hernia.

Official Title
-----------------
Spontaneous Evisceration of Infantile Umbilical Hernia

Conditions
-----------------
Pediatric Disorder

Intervention / Treatment
-----------------
* Procedure: Exploration


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pediatric group Exclusion Criteria: Adult group

Ages Eligible for Study
-----------------
Minimum Age: 1 Month
Maximum Age: 3 Years

Sexes Eligible for Study
-----------------
Male

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| case report<br> | Procedure: Exploration<br>* abdominal exploration<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hospital stay | hospital stay | From April 1, 2023 to April 1, 2024 |
Performance of Artificial Intelligence Tools and Ultrasonographers With Different Skills

Study Overview
=================
Brief Summary
-----------------
Artificial intelligence versus different skilled sonographers.

Detailed Description
-----------------
Comparison of artificial intelligence and ultrasonographers with different skills in diagnosing intussusception in children and identifying indications for surgery.

Official Title
-----------------
Comparison of Artificial Intelligence and Ultrasonographers With Different Skills in Diagnosing Intussusception in Children and Identifying Indications for Surgery

Conditions
-----------------
Ileocolic Intussusception

Intervention / Treatment
-----------------
* Diagnostic Test: Non-invasive diagnosis of ileocolic intussusception by ultrasound with indication for surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children aged 3-36 months with suspected ileocolic intussusception Exclusion Criteria: Children younger than 3 months or older than 36 months with suspected ileocolic intussusception

Ages Eligible for Study
-----------------
Minimum Age: 3 Months
Maximum Age: 36 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients aged 3-36 months with suspected ileocolic intussusception<br>Patients aged 3-36 months with suspected ileocolic intussusception | Diagnostic Test: Non-invasive diagnosis of ileocolic intussusception by ultrasound with indication for surgery<br>* Non-invasive diagnosis of ileocolic intussusception by ultrasound with indication for surgery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ultrasound diagnosis of ileocolic intussusception | Ultrasound diagnosis of ileocolic intussusception | April 9, 2023 to May 10, 2023 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Surgical indication of ileocolic intussusception identified by ultrasound | Surgical indication of ileocolic intussusception identified by ultrasound | April 9, 2023 to May 10, 2023 |
Faecal Microbiota Transplantation for Microscopic Colitis

Study Overview
=================
Brief Summary
-----------------
A pilot study investigating if orally administrated faecal microbiota transplantation capsules have the potential to treat active microscopic colitis.

Official Title
-----------------
Faecal Microbiota Transplantation for Microscopic Colitis

Conditions
-----------------
Microscopic Colitis

Intervention / Treatment
-----------------
* Other: Faecal Microbiota Transplantation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of microscopic colitis Date of diagnosis/histological confirmation < 12 months Active disease according to Hjortswang's criteria Exclusion Criteria: Diagnosed with ulcerative colitis or Crohn's disease Diagnosed with celiac disease Active gastrointestinal infection Previous bowel resection of bowel (except appendectomy) Previous cholecystectomy Treatment with systemic steroid within 4 weeks, including budesonide Antibiotics 3 months prior Severe immunodeficiency, Pregnancy, planned pregnancy and breastfeeding Treatment with constipants such as psyllium, loperamide, bile binders, opium drops or codeine up to 2 weeks before inclusion and during participation

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: pilot trial
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Faecal Microbiota Transplantation|treatment with capsules|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment effect | Proportion of participants in remission | 3 weeks |