Magnetic Resonance Imaging in Radiotherapy for Breast Cancer

Study Overview
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Brief Summary
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This is a single-center, prospective pilot study evaluating feasibility and efficacy of incorporating magnetic resonance imaging (MRI) simulation into the planning of radiation treatment (RT) for breast cancer.

Detailed Description
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PRIMARY OBJECTIVE: I. To determine feasibility of acquiring MRI simulation prior to RT planning. EXPLORATORY OBJECTIVE: I. To determine change in target volume with MRI simulation compared to Computerized tomography (CT) simulation. OUTLINE: MRI simulation will be performed once at baseline. There is no follow up planned for study purposes. Patients will be followed as part of their regular clinical care.

Official Title
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Magnetic Resonance Imaging in RadiotheRapy fOr bReast Cancer (MIRROR): A Pilot Study of MRI Simulation

Conditions
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Breast Cancer

Intervention / Treatment
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* Diagnostic Test: Magnetic Resonance Imaging Simulation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants with an Eastern Cooperative Oncology Group (ECOG) performance status <=2 (or Karnofsky ≥>=60%, see Appendix A). Participants with the ability to understand and the willingness to sign a written informed consent document. Participants may separately enroll on therapeutic clinical trials when they enroll on this trial. Note: All interventions on this protocol are standard of care, so enrollment on other therapeutic protocols is allowed at the discretion of the treating physician. Patients must have pathologically confirmed invasive or in situ breast cancer. Patients must have tumors in which adjuvant breast radiotherapy following breast conserving surgery is indicated, as determined by the treating physician. Patients must be female. Note: Male patients are excluded due to the rarity of male breast cancer and difficulty in pursuing breast conserving surgery for male patients. Exclusion Criteria: Participants with a contraindication to MRI per the MRI checklist. Patients with breast tumor or tumor bed not visualized at CT or MRI during RT planning.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Breast Cancer Participants<br>Participants will receive both MRI and CT simulation scans. | Diagnostic Test: Magnetic Resonance Imaging Simulation<br>* Radiographic Image Simulation<br>* Other names: MRI;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of participants who completed scan | Feasibility feasibility of acquiring MRI simulation prior to RT planning is defined as successfully acquiring MRI data at the specified time point in a participant's radiotherapy (RT) care plan | Day of MR imaging (1 day) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Imaging