Correlation Between Angle Closure Glaucoma Data and Lens Zonule Status

Study Overview
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Brief Summary
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The goal of this observational study is to discuss the correlation between primary angle-closure glaucoma and the state of the suspended ligament of the lens and the pathogenesis of PACG by measuring the biological data of primary angle-closure glaucoma and observing its anatomical changes.

Detailed Description
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Patients clinically diagnosed with Primary angle-closure glaucoma (PACG) and normal control patients from December 2020 to January 2022 were enrolled in this study.

Official Title
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Correlation Between Angle Closure Glaucoma Data and Lens Zonule Status

Conditions
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Primary Angle Closure Glaucoma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The depth of the anterior chamber is normal, and the whole corner of the chamber is open; The cup-to-plate ratio is less than 0.5; No family history of glaucoma. Exclusion Criteria: Previous history of trauma or internal eye surgery in both eyes or one eye; Used pilocarpine, atropine and other drugs to change the size of the pupil and the shape of the chamber Angle within 1 week; Combined with other eye diseases affecting the Angle and suspension ligament, such as uveitis, ciliary cyst, high myopia, retinal diseases, etc.; Can not cooperate with UBM and Angle scopy; Refuse to participate in this researcher.

Ages Eligible for Study
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Minimum Age: 47 Years
Maximum Age: 91 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PACG group<br>All patients in the experimental group met the diagnostic criteria of primary angle-closure glaucoma in the Chinese Glaucoma Guidelines(2020). | |
| control group<br>The depth of the anterior chamber is normal, and the whole corner of the chamber is open; The cup-to-plate ratio is less than 0.5; No family history of glaucoma | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Axial Length (AL), Lens Thickness (LT),Lens Vault (LV), Pupil Diameter (PD), | Axial Length (AL), Lens Thickness (LT),Lens Vault (LV), Pupil Diameter (PD), | before operation | 
| Anterior Chamber Depth (ACD) in seat and rectum position, White To White (WTW), pupil vault (LV), pupil diameter (PD), The Lens Zonular Length (LZL) and Angle Opening Distance at 500μm (AOD500) in the upper, lower, nasal and temporal directions | Anterior Chamber Depth (ACD) in seat and rectum position, White To White (WTW), pupil vault (LV), pupil diameter (PD), The Lens Zonular Length (LZL) and Angle Opening Distance at 500μm (AOD500) in the upper, lower, nasal and temporal directions | before operation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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primary angle closure glaucoma, UBM, lens zonule