Prospective Validation of Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery

Study Overview
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Brief Summary
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Validation of Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery: A Multicenter, Prospective, and Cohort Study

Detailed Description
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A clinical prediction model for VTE after neurosurgical procedures during hospitalization has been developed and internally retrospectively validated. A multicenter, prospective cohort study is planned to validate this clinical prediction model again.

Official Title
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Prospective Validation of Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery

Conditions
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Venous Thromboembolism, Neurosurgery, Risk Assessment

Intervention / Treatment
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* Diagnostic Test: Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age >18 years underwent neurosurgical procedures during hospitalization underwent preoperative ultrasound examination Exclusion Criteria: a patient with obvious bacterial or viral infection within the past two weeks before admission a patient with venous thromboembolism within the past three months before surgery a patient with anticoagulant therapy (direct oral anticoagulants, low molecular weight heparin) was administered continuously or intermittently before admission a patient with a prior coagulation dysfunction

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery|This is a clinical prediction model that uses perioperative clinical indicators and laboratory tests to predict the occurrence of VTE after neurosurgery.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Symptomatic or asymptomatic VTE | A combination of symptomatic or asymptomatic DVT and symptomatic or asymptomatic PE | 2023.3-2023.7 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| DVT | A blood clot within a deep vein, typically in the thigh or leg, which is detected with compressible ultrasound, venography, impedence plethysmography, radiofibrinogen uptake scanning or autopsy based on the time of study. This outcome combines proximal or distal DVT of the leg, upper limb DVT | 2023.3-2023.7 | 
| PE | Obstruction of a pulmonary artery or one of its branches that is usually produced by a blood clot which has originated in a vein of the leg or pelvis and traveled to the lungs, which is diagnosed by CT pulmonary angiography, ventilation-perfusion lung scanning pulmonary angiogram, or by autopsy or equivalent technology based on the time of study. This outcome combines saddle, lobar, segmental or subsegmental PE according to the anatomic location | 2023.3-2023.7 | 
| Proximal DVT | Proximal DVT is a blood clot that is located in the popliteal, femoral, or iliac veins, which is detected with compressible ultrasound, venography, impedence plethysmography, radiofibrinogen uptake scanning or autopsy based on the time of study | 2023.3-2023.7 |