Epidemiological and Clinical Characteristics of Hospitalized Patients Under 5 Years Old With RSV Infection in Central China, Wuhan

Study Overview
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Brief Summary
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The study will be a multicenter, hospital-based retrospective study. We plan to collect the clinical and laboratory data among all hospitalized ARTI cases in three hospitals in Wuhan from June 1, 2020 to May 31, 2023 and then analyze the epidemiological and clinical characteristics of RSV infection, clarify the gene types of epidemics under 5 years old children after the outbreak in Wuhan, China.

Official Title
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Epidemiological and Clinical Characteristics of Hospitalized Patients Under 5 Years Old With RSV Infection in Central China, Wuhan

Conditions
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RSV Infection

Intervention / Treatment
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* Other: Observation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ①Admission age <5 years old ②Clinical diagnosis of acute respiratory tract infections Exclusion Criteria: Hospital acquired ARTI

Ages Eligible for Study
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Minimum Age: 1 Day
Maximum Age: 5 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Neonatal<br> | Other: Observation<br>* clinical manifestation (body temperature, fever days before admission, cough, red throat/sore throat, runny nose, shortness of breath, wheezing, vomiting), physical signs (auscultation of lungs, X-ray results), length of stay, therapeutic measures (oxygen therapy, ICU admission, antibiotic therapy, etc.)<br>|
| 1-3 months old<br> | Other: Observation<br>* clinical manifestation (body temperature, fever days before admission, cough, red throat/sore throat, runny nose, shortness of breath, wheezing, vomiting), physical signs (auscultation of lungs, X-ray results), length of stay, therapeutic measures (oxygen therapy, ICU admission, antibiotic therapy, etc.)<br>|
| 3-6 months old<br> | Other: Observation<br>* clinical manifestation (body temperature, fever days before admission, cough, red throat/sore throat, runny nose, shortness of breath, wheezing, vomiting), physical signs (auscultation of lungs, X-ray results), length of stay, therapeutic measures (oxygen therapy, ICU admission, antibiotic therapy, etc.)<br>|
| 6 months-1 year old<br> | Other: Observation<br>* clinical manifestation (body temperature, fever days before admission, cough, red throat/sore throat, runny nose, shortness of breath, wheezing, vomiting), physical signs (auscultation of lungs, X-ray results), length of stay, therapeutic measures (oxygen therapy, ICU admission, antibiotic therapy, etc.)<br>|
| 1-2 years old<br> | Other: Observation<br>* clinical manifestation (body temperature, fever days before admission, cough, red throat/sore throat, runny nose, shortness of breath, wheezing, vomiting), physical signs (auscultation of lungs, X-ray results), length of stay, therapeutic measures (oxygen therapy, ICU admission, antibiotic therapy, etc.)<br>|
| 2-5 years old<br> | Other: Observation<br>* clinical manifestation (body temperature, fever days before admission, cough, red throat/sore throat, runny nose, shortness of breath, wheezing, vomiting), physical signs (auscultation of lungs, X-ray results), length of stay, therapeutic measures (oxygen therapy, ICU admission, antibiotic therapy, etc.)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of patients with fever | number of patients with fever | at admission | 
| number of patients with cough | number of patients with cough | at admission | 
| number of patients with shortness of breath | number of patients with shortness of breath | at admission | 
| number of patients with shortness of wheeze | number of patients with shortness of wheeze | at admission | 
| number of patients with shortness of vomit | number of patients with shortness of vomit | at admission | 
| number of patients with shortness of rale | number of patients with shortness of rale | at admission | 
| number of patients with shortness of stridor | number of patients with shortness of stridor | at admission | 
| age | age | at admission | 
| gender | female/male | at admission | 
| number of patients with underlying disease | underlying disease include immune deficiency, CHD, BPD, BO, bronchiectasis and asthma and so on | at admission | 
| Imaging examination results | X-Ray/CT | through study completion, an average of 1 year | 
| length of hospital stay length of stay length of stay | length of hospital stay | through study completion, an average of 1 year | 
| number of patients with treatment of antibiotic | number of patients with treatment of antibiotic | through study completion, an average of 1 year | 
| number of patients with treatment of immunoglobulin | number of patients with treatment of immunoglobulin | through study completion, an average of 1 year | 
| number of patients with treatment of glucocorticoids | number of patients with treatment of glucocorticoids | through study completion, an average of 1 year | 
| number of patients with treatment of oxygen inhalation | number of patients with treatment of oxygen inhalation | through study completion, an average of 1 year | 
| number of patients with treatment of ventilation | number of patients with treatment of ventilation | through study completion, an average of 1 year | 
| direct medical cost | direct medical cost | through study completion, an average of 1 year | 
| proportion of different virus genotype | virus genotype include A, B and C | through study completion, an average of 1 year | 
| F protein gene sequence | F protein gene sequence | through study completion, an average of 1 year | 
| number of patients infected with bacteria | number of patients infected with bacteria | through study completion, an average of 1 year | 
| number of patients infected with virus | number of patients infected with virus | through study completion, an average of 1 year | 
| number of patients infected with fungus | number of patients infected with fungus | through study completion, an average of 1 year |