External Oblique Intercostal Plane Block for Liver Transplantation Donors

Study Overview
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Brief Summary
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Postoperative pain management is one of the important factors to improve rehabilitation and enhance recovery. External oblique intercostal plane block may be used for abdominal wall analgesia to provide effective analgesia for abdominal surgery. The aim of this study is to investigate the postoperative analgesic efficacy of external oblique intercostal plane block and subcostal transversus abdominis plane block in living liver donors. Researchers will compare the external oblique intercostal plane block group with subcostal transversus abdominis plane block to see if the external oblique intercostal plane block is effective for postoperative analgesia in living liver donors.

Detailed Description
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Patients scheduled for living donor hepatectomy will be separated into 2 groups: Subcostal Transversus Abdominis Plane Block Group and External Oblique Intercostal Plane Block Group. Patients in Subcostal Transversus Abdominis Plane Block will be performed subcostal transversus plane block at the end of the surgery and after skin closure and received patient controlled analgesia with morphine for postoperative analgesia. Patients in External Oblique Intercostal Plane Block Group will be performed bilateral External Oblique Intercostal Plane Block at the end of the surgery and after skin closure and received patient controlled analgesia with morphine for postoperative analgesia. Morphine consumption for first postoperative 24 hours, visual analog scale scores, time to need for first rescue analgesia, amount of rescue analgesic drug, incidence of postoperative nausea and vomiting will be recorded.

Official Title
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External Oblique Intercostal Plane Block for Postoperative Analgesia in Living Liver Donors

Conditions
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Liver Transplantation, Donor, Postoperative Pain

Intervention / Treatment
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* Other: Subcostal transversus abdominis plane block
* Other: External oblique intercostal plane block


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age between 18 and 75 years Patients with American Society of Anesthesiology (ASA) physical status I-II Patients scheduled for a living donor hepatectomy Exclusion Criteria: Allergy to local anesthetics Coagulopathy Skin infection at the block area Advanced renal failure Chronic pain syndromes Alcohol or drug abuse Psychiatric disorders

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Subcostal transversus abdominis plane block group<br>The patients in subcostal transversus abdominis plane block group will be received subcostal transversus abdominis plane block and patient controlled analgesia with morphine for postoperative analgesia | Other: Subcostal transversus abdominis plane block<br>* External oblique intercostal plane block will be administered at the end of the surgery and after skin closure.<br>|
| Active Comparator: External oblique intercostal plane block group<br>The patients in External oblique intercostal plane block group will be received external oblique intercostal plane block and patient controlled analgesia with morphine for postoperative analgesia | Other: External oblique intercostal plane block<br>* External oblique intercostal plane block will be administered at the end of the surgery and after skin closure. .<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Morphine consumption | The amount of morphine required by the patient and given by the device will be recorded for the first 24 hours. | Postoperative 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative visual analog scale scores | Postoperative pain will be assessed using a visual analog scale (VAS) (from 0 = no pain to 10 = maximum possible pain) for the first 24 hours. | Postoperative 24 hours | 
| Rescue analgesic drug consumption | The amount of rescue analgesic in mg required by the patient will be recorded for the first 24 hours. | postoperative 24 hours | 
| Incidence of postoperative nausea and vomiting | Number of patients developing postoperative nausea and vomiting will be recorded for the first 24 hours | postoperative 24 hours |