Awake Prone Positioning for COVID-19 Acute Hypoxaemic Respiratory Failure

Study Overview
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Brief Summary
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The objective of our study is to evaluate the effectiveness of prone position in preventing intubation or death in spontaneously ventilated patients with COVID-19 with acute respiratory failure.

Detailed Description
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The COVID-19 pandemic has challenged the management of hypoxemic respiratory failure as limited ICU capacity is strained by a new high-mortality disease and large numbers of patients requiring prolonged periods of hospitalization, as well as respiratory support equipment such as ventilators and intensive care unit (ICU) beds. If early and prolonged prone positioning (DV) reduces mortality in invasively ventilated patients with acute respiratory distress syndrome (ARDS), its role in conscious patients (DV vigil) remains a subject of debate and research. This is a retrospective, monocentric, descriptive and analytical cohort conducted over a period of 22 months from March 2020 to December 2021 and involving 1069 patients hospitalized in the intensive care unit of the CHU Mohammed VI of Oujda for the management of acute respiratory failure caused by COVID-19.

Official Title
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Awake Prone Positioning for COVID-19 Acute Hypoxaemic Respiratory Failure: Retrospective Cohort Study

Conditions
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Survival, Prosthesis, Oxygen Deficiency

Intervention / Treatment
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* Other: Prone position


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: all patients (1069 patients) with ARDS due to SARS-cov2, confirmed by nasopharyngeal swab, who were hospitalized in the COVID-19 ICU from March 1, 2020 to December 31, 2021 Exclusion Criteria: Patients with negative CRP Younger than 18 years of age Patients who died or intubated on the day of admission Patients presented a contraindication

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Includes 681 patients who were placed in prone position<br> | Other: Prone position<br>* Each prone position session had a minimum duration of one hour and a maximum duration of 12 hours for a minimum of 3 hours per day.<br>|
| Includes 388 patients who were placed in supine position<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate the effectiveness of awake prone position in preventing intubation or death in spontaneously ventilated patients with COVID-19 with acute respiratory failure. | Evaluate the effectiveness of awake prone position in preventing intubation or death in spontaneously ventilated patients with COVID-19 with acute respiratory failure. | 22 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| length of stay in intensive care unit, length of time from hospitalization to death, length of time from hospitalization to intubation. | length of stay in intensive care unit, length of time from hospitalization to death, length of time from hospitalization to intubation. | 22 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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acute respiratory distress syndrome, COVID-19, conscious, prone position, survival rate