Patient Knowledge, Beliefs and Barriers to Hepatitis D Care

Study Overview
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Brief Summary
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A project to understand the determinants of health behaviour among those with chronic hepatitis D virus (HDV) infection, under the care of the viral hepatitis service at Kings College Hospital (KCH). This is to improve and implement pathways and patient information distribution to improve access to care in an ethnically diverse population living with HDV in the UK. Kings college hospital NHS Foundation Trust is uniquely placed and serves a large diverse population from areas such as pan pacific Asia, Eastern Europe and regions in Africa, where English is not their first language. This diversity is also seen in other London Hospitals but less so in other parts of the UK.

Detailed Description
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To understand the knowledge patients have around their diagnosis of hepatitis D which is considered a rare disease but the most aggressive form of viral hepatitis. In order to improve the management of hepatitis D, this research aims to identify the current knowledge patients have about their diagnosis, the information provided to them in their preferred language, how they feel about their diagnosis and the stigma attached. This research has been conducted in patients with other forms of viral hepatitis but not in patients living with hepatitis D. There is a lack of research in this area. With this research we aim to improve treatment pathways, access to care and to information.

Official Title
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Patient Knowledge, Beliefs and Barriers to Hepatitis D Care; Single Site Observational Study

Conditions
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Hepatitis, Delta

Intervention / Treatment
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* Other: Questionnaire based intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Participants 18 years or older. HDV infection as diagnosed by high levels of anti-HDV immunoglobulin G (IgG) and immunoglobulin M (IgM), and confirmed by detection of HDV RNA in serum. Treated HDV infection Willing and able to provide written informed consent. Exclusion Criteria: Clinically significant medical or psychiatric illness in the past, present, or being evaluated, that may interfere with participant treatment, safety and assessment.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Questionnaire based intervention|Three validated questionnaires amended from hepatitis B to D (Chronic liver disease questionnaire, self-stigma scale and HBV virus knowledge scale) will be used.|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The overall patient understanding of Hepatitis D Virus diagnosis | Use of modified CLDQ - HBV survey. Scale of 1-7 with lower scores indicating worse outcomes | 6 months | 
| Describe overall patient knowledge around HDV | Modified HBV knowledge scale survey. Yes or No as options | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Describe stigma attached towards HDV | Use of modified Toronto HBV stigma questionnaire. Scale options are: never, rarely, sometimes, often, always | 6 months | 
| Understand satisfaction with communication regarding HDV care at KCH | Use of local viral hepatitis service questionnaire | 6 months |