The Application of the New Magnetic Resonance UTE Technique in Thoracic Lesions

Study Overview
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Brief Summary
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Quantitative characteristic values of lung lesions were obtained by UTE technique, so as to make qualitative diagnosis of benign and malignant lesions. And to explore the clinical feasibility of CT-like technology - high resolution ZTE technology in the diagnosis of pulmonary diseases.

Detailed Description
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Ultrashort echo time (UTE) sequence can obtain data from T2* for lung imaging before T2* decays in lung parenchyma with extremely short echo time, which makes up for the defect that conventional MRI cannot clearly display short T2 tissue imaging, and can provide more supplementary information for lung CT scan. There has been a lot of research progress in the evaluation of neonatal lung disease, chronic obstructive airway disease and pneumonia. The 3D UTE sequence developed on this basis has made great progress in improving the resolution, signal-to-noise ratio and shortening the scanning time of lung MR Images, and has successfully obtained submillimeter high-resolution images. The purpose of this study was to explore the value of MRI ultra-short echo technology in the qualitative diagnosis of benign and malignant lung lesions, and to explore the clinical application of CT-like technology - high resolution ZTE technology in the lung.

Official Title
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The Application of the New Magnetic Resonance Technique-UTE in Thoracic Lesions

Conditions
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Lung Diseases

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥18 years old; There are lung lesions, and the solid component is ≥6mm; Chest CT plain scan or /+ enhanced examination within 4 weeks. Exclusion Criteria: There are metal implants in the corresponding parts of the chest; MRI contrast agent allergy; Claustrophobia; Pregnant women; High fever; Respiratory failure; Lung lesion biopsy within 4 weeks prior to examination.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| benign group<br>benign lesions in the lung | |
| malignant group<br>malignant tumor in the lung | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| proton density fat fraction (PDFF) | Determination of proton density fat fraction by magnetic resonance imaging | baseline (before surgery) | 
| T2 relaxation rate | R2* | baseline (before surgery) | 
| Magnetization Transfer Ratio (MTR) | Magnetization Transfer Ratio | baseline (before surgery) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subjective rating | rating scale | baseline (before surgery) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lung mass, UTE, ZTE, nodule, MRI