Articulatory Adaptation Following Oral Cancer Treatment

Study Overview
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Brief Summary
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The goal of this longitudinal study is to learn more about the articulatory consequences of surgical oral cancer treatment. The main aims are to study the coordination and development of speech articulation of patients who will undergo surgical treatment for oral cancer longitudinally and whether individual differences in the reliance on auditory or tactile information can predict the success of speech compensatory strategies. Participants will perform multiple speech tasks while motion tracking sensors track the articulatory gestures.

Official Title
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Speech Flexibility in Adulthood Following Oral Cancer Treatment: Acoustic and Kinematic Explorations

Conditions
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Oral Cavity Squamous Cell Carcinoma, Speech Disorders

Intervention / Treatment
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* Other: Electromagnetic Articulography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed with T1 or T2 tumor in the oral cavity At least 18 years old and able to provide informed consent Native speaker of Dutch Has nog been treated for oral cancer before Exclusion Criteria: 1a. Recurrence of disease (for patients) 1b. Treated for oral cancer (for healthy controls) 2. Speech problems (e.g., stuttering) 3. Problems with sight or hearing that impede reading or understanding instructions. When glasses or a hearing aid resolve these problems, then participants are not excluded. 4. Neurological or psychological disorders (e.g., stroke) 5. Non-removable metal in, on or around the head (piercings, braces, pacemaker, electrodes) 6. Self-reported signs of depression

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Individuals treated for oral cancer<br>Dutch native speakers (18+) who will undergo surgical treatment for a T1 or T2 tumour on the tongue. | Other: Electromagnetic Articulography<br>* Motion tracking sensors will track articulatory movements of the tongue, jaw and lips<br>|
| Control speakers<br>Dutch native speakers (18+) without self-reported speech problems. | Other: Electromagnetic Articulography<br>* Motion tracking sensors will track articulatory movements of the tongue, jaw and lips<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Articulatory gestures | Articulatory movements in three dimensions of the tongue, lips and jaw as measured by the NDI Vox Electromagnetic Articulograph. Measures include: articulator speed (mm/s), total displacement (mm), coordinates (x,y,z) during specific gestures. | 2022-2025 | 
| Acoustic outcomes | Speech acoustics will be measured in Praat and include the first and second formants of vowels (in Hz), global movement size in terms of acoustic working space (Hz-squared), and the centre of gravity of sibilants (in Hz) | 2022-2025 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Articulation