Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease

Study Overview
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Brief Summary
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This study aims to characterize dynamic stability disorders in two conditions mainly affecting the elderly and with similar walking deficits: hydrocephalus at normal pressure and Parkinson's disease, to provide the most relevant monitoring criteria in usual care.

Detailed Description
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Walking disorders in normal pressure hydrocephalus are manifested by slowing and ataxic gait, similar to disorders in Parkinson's disease. No studies in the literature have focused on advanced measures of dynamic stability in hydrocephalus at normal pressure, compared to Parkinson's disease, on large samples. The Laboratory of Analysis and Restoration of Movement, located in a Neurorehabilitation Department, provides quantitative data on gait and in particular dynamic stability as part of additional assessments to help patients follow up. Since 2010, people with normal pressure hydrocephalus or Parkinson's disease regularly benefit from these assessments. Retrospective analysis of all these data would help to better characterize motor disorders in hydrocephalus at normal pressure, by discriminating them from those associated with Parkinson's disease. It would lead to the definition of relevant indices to be used for patient follow-up.

Official Title
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Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease

Conditions
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Hydrocephalus, Parkinson Disease, Walking, Difficulty, Movement Disorders, Gait Ataxia, Diagnoses Disease

Intervention / Treatment
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* Diagnostic Test: Dynamic stability measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age >18 years Patient who performed a walking test in the Laboratory Analysis and Restoration of Movement Diagnosis of normal pressure hydrocephalus or Parkinson's disease Exclusion Criteria: Levodopa drugs administrated during a delay of 12 hours before walking test Presence of an other neurologic disease or of any disease associated with motor disorders in lower limb.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normal pressure hydrocephalus<br>Patients with a diagnosis of normal pressure hydrocephalus and who performed a gait analysis in laboratories | Diagnostic Test: Dynamic stability measurement<br>* The subject is asked to walk 8 meters 3 times: at free speed, at fast speed, and with large steps.<br>|
| Parkinson's disease<br>Patients with a diagnosis of Parkinson's disease and who performed a gait analysis in laboratories | Diagnostic Test: Dynamic stability measurement<br>* The subject is asked to walk 8 meters 3 times: at free speed, at fast speed, and with large steps.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Coefficient of variation in step length | Coefficient of variation in step length during 8-meter comfortable walking test | 30 seconds |