Cutaneous Diphtheria in France : Observational, Retrospective Study of Patient Characteristics

Study Overview
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Brief Summary
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Toxigenic cutaneous diphtheria is a notifiable disease that is re-emerging in the world and particularly in France. A better description of the epidemiological characteristics, as well as a refinement of the clinical characteristics of patients with cutaneous diphtheria, are essential to better understand this pathology, which has important public health issues and whose diagnosis absence can have catastrophic consequences for the patient and their contacts. Microbiological data (species identification, toxigenicity or not, resistance profile...) will be transmitted by the national reference center for corynebacteria of the diphtheriae complex and then caregivers who have managed the corresponding patients with cutaneous diphtheria will be contacted.

Official Title
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Cutaneous Diphtheria in France : an Observational, Retrospective Study of Epidemiological, Clinical, Microbiological and Therapeutic Characteristics

Conditions
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Corynebacterium Diphtheriae Infection

Intervention / Treatment
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* Other: Characteristics description


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Culture or PCR positive skin samples for corynebacteria diphtheria, ulcerans, pseudotuberculosis, belfantii or rouxii Patient living in metropolitan France Exclusion Criteria: - Patient opposition

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with cutaneous diphteria<br>The study group consists of all the patients suffering from cutaneous diphtheria in metropolitan France and for which microbiological data were registered by the National Reference Center fo corynebacteria of the diphteriae complex between 2018 and 2022. | Other: Characteristics description<br>* Caregivers who follow the patients of the study group will be contacted to collect these patients clinical and epidemiological characteristics<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patients epidemiological data description | Epidemiological data will be collected to describe the studied population (age, sex, place of birth, vaccination status...) | 3 months | 
| Patients clinical data description | Clinical data will be collected to describe the studied population (history, description of lesions, disease evolution, complications...) | 3 months | 
| Patients microbiological data description | Microbiological data will be collected to describe the studied population (species identification, toxigenicity, presence of a co-infection...) | 3 months | 
| Patients therapeutic data description | Therapeutic data will be collected to describe the studied population (antibiotic therapy, duration of treatment, search for an eradication a posteriori...) | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of antibiotic therapy duration to national recommendations issued by the High Committee of Public Health | Duration of antibiotic therapy implemented by clinicians will be compared to national recommendations | 3 months | 
| Comparison of immunization status monitoring to national recommendations issued by the High Committee of Public Health | Monitoring of immunization status or not will be collected | 3 months | 
| Comparison of patient post infection vaccination status to national recommendations issued by the High Committee of Public Health | Post-infection vaccination or not will be collected | 3 months | 
| Comparison of patient microbiological follow-up to national recommendations issued by the High Committee of Public Health | Microbiological follow-up with eradication research or not will be collected. | 3 months | 
| Comparison of post-infection serological sampling to national recommendations issued by the High Committee of Public Health | Whether a post-infection serological sampling was performed or not will be collected. | 3 months | 
| Comparison of patient isolation procedures to national recommendations issued by the High Committee of Public Health | Patient isolation or not will be collected. | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cutaneous, Diphteria