The Relationship Between Serum Gasdermin-D Levels and Pyroptosis and Preterm Labor

Study Overview
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Brief Summary
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In this study, the investigators aimed to investigate the relationship between Gasdermin D levels measured from the maternal serum of patients diagnosed with preterm labor and spontaneous preterm labor in pregnant women.

Detailed Description
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This prospective case- control study was conducted between 15 July 2021 and 15 July 2022 at Bursa Yüksek İhtisas Training and Research Hospital. The study was conducted with pregnant women between the ages of 18-45 who were idiopathic preterm labor. Pregnant women between the ages of 18-45 who were diagnosed with preterm labor between 24-37 weeks of gestational were included. This study was conducted with 160 pregnant women who were diagnosed with idiopathic preterm labor and 167 healthy pregnant women who were in the same gestational week as these pregnant women and were not diagnosed with preterm labor. Group 1 patients diagnosed with preterm labor between 24-37 weeks( study group) (n:160), Group 2 consisted of healthy pregnant women who were not diagnosed with preterm labor between 24-37 weeks ( control group) (n: 167) . In group 1, 80 patients were diagnosed with early preterm (between 24-34 weeks ) and 80 patients with late preterm labor (34-36+6 weeks).

Official Title
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Research of the Relationship Between Serum Gasdermin-d Levels and Pyroptosis and Preterm Labor

Conditions
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Gasdermin D Levels in Preterm Labor

Intervention / Treatment
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* Other: Gasdermin-d


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pregnant women who were diagnosed with idiopathic preterm labor and gave birth in our hospital Pregnant women without vaginal infection Healthy pregnant women between 24-37 weeks without a diagnosis of preterm labor Exclusion Criteria: Multiple pregnancies Pregnant women with a prediagnosis of chromosomal and congenital anomalies in the fetus Women with a known infective or autoimmune disease before pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Gastermin D and Pentaxin 3 levels were measured in the patients participating in the study. These are not routinely checked markers. Participants were assigned prospectively to an intervention or interventions according to a protocol to evaluate the effect of the intervention(s) on preeclampsia or HELLP related outcomes. Due to this, our work is interventional.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Gasdermin-D levels in preterm labor (study group)<br>Maternal serum Gasdermin-D levels of pregnant women who were diagnosed with idiopathic preterm labor | Other: Gasdermin-d<br>* Maternal serum Gasdermin-D levels in preterm labor and healthy pregnant women.<br>|
| Other: Gasdermin-D levels in healthy pregnant women (control group)<br>Maternal serum Gasdermin-D levels of healthy pregnant women | Other: Gasdermin-d<br>* Maternal serum Gasdermin-D levels in preterm labor and healthy pregnant women.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| relationship between Gasdermin-D levels in preterm labor | the relationship between Gasdermin-D levels of patients diagnosed with preterm labor and spontaneous preterm labor in pregnant women. | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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gasdermin D, preterm labor, pyroptosis