Project PEER: Understanding the Lung Cancer Patient ExperiEnce in the Real-World Setting

Study Overview
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Brief Summary
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LUNGevity Foundation, a non-profit lung cancer organization, wants to learn about living with lung cancer from the point of view of people with lung cancer and their family and friends who provide care. To do this, we have an online study designed to better understand how treatments people living with lung cancer receive impact their quality of life. Participants will complete surveys once a month for 12 months. What does participation involve? Emailing the study team to learn more and get access to the study website. Once a month for 12 months you will receive a survey by email. Complete these surveys on a smartphone, tablet, or computer at your convenience and receive an e-gift card for your time.

Detailed Description
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PEER is an international study, that is Institutional Review Board (IRB) approved and General Data Protection Regulation (GDPR) compliant. The study objective is to collect longitudinal data to facilitate a rigorous understanding of the diagnostic and treatment experiences of people diagnosed with lung cancer and to identify determinants of treatment heterogeneity. Study data will be used to understand the diagnostic and treatment pathways, explore patient-experience data in different domains (financial impact/quality of life/symptoms) and test the hypothesis that different classes of therapies (chemotherapy/ immunotherapy/ targeted therapy/ surgery/ radiation) impact patient experience (eg., physical function). Study participants will consent and register for the study and complete an initial baseline survey. They will then be followed for 12 months and receive a monthly survey (11 surveys in total) via email. The development of the surveys was guided by input from patients, clinicians, FDA experts, and incorporates questions from existing patient-reported outcomes (PRO) measures. Summarized study results will also be posted on LUNGevity's website. External researchers will be able to apply to have limited access to de-identified data.

Official Title
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Project PEER: Understanding the Lung Cancer Patient ExperiEnce in the Real-World Setting

Conditions
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Lung Cancer Patients, Caregivers

Intervention / Treatment
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* Other: There are no interventions in this study. All participants complete online surveys.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults with self-reported lung cancer diagnosis or caregiver of someone with a self-reported lung cancer diagnosis (patient has to be alive) Ability to read and answer questions in English Access and ability to use a computer or other internet-connected device Exclusion Criteria: Younger than 18 Healthcare providers and healthcare professionals who provide care to lung cancer patients except for those who are themselves a patient or a caregiver to a loved one. Not able to provide informed consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients<br>Individuals who have been diagnosed with lung cancer. Individuals with all stages of lung cancer and individuals who have reached no evidence of disease (NED). | Other: There are no interventions in this study. All participants complete online surveys.<br>* There are no interventions in this study. All participants complete online surveys.<br>* Other names: Other;|
| Caregivers<br>Family and friends who provide care for someone who has been diagnosed with lung cancer | Other: There are no interventions in this study. All participants complete online surveys.<br>* There are no interventions in this study. All participants complete online surveys.<br>* Other names: Other;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Explore guideline concordant care | Patient-reported treatments will be explored in relation to other clinical data provided (e.g., biomarker presence) and the National Comprehensive Cancer Network (NCCN) guidelines for those clinical characteristics at the time of treatment. | From baseline and assessed monthly up to end of study (up to approximately 12months) | 
| Explore patient-reported functioning, symptoms, side effects and overall quality of life | Patterns based on disease staging and treatment class will be explored using the European Organisation for Research and Treatment of Cancer Quality of Life 30-item questionnaire (EORTC QLQ-C30), the Non-Small Cell Lung Cancer Symptom Assessment Questionnaire (NSCLC-SAQ), and a side effect questionnaire to explore these patient-reported outcomes. Scores for the EORTC QLQ-C30 are transformed so that for each subscale the range is 0-100. For functioning subscales, higher scores indicate better functioning, and for symptoms higher scores indicate more symptom burden. Scores for the NSCLC-SAQ range from 0-20, with higher scores indicating more severe symptomology. | From baseline and assessed monthly up to end of study (up to approximately 12months) | 
| Explore impacts of different classes of therapies | Test whether different classes of therapies (e.g., chemotherapy/ immunotherapy/ targeted therapy/ surgery/ radiation) impact patient experience (e.g., side effects, functioning). Both within and between patient experiences will be investigated. Results from Project PEER will be compared currently existing clinical trial data. | From baseline and assessed monthly up to end of study (up to approximately 12months) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lung cancer, Patient, Caregiver, Smoker, Non-smoker, Tobacco use, Tobacco exposure, Biomarker, Non-small cell lung cancer (NSCLC), Small cell lung cancer (SCLC), Quality of life, Treatment