Effect of Sarcopenic Obesity on Weight Loss Outcomes and Quality of Life After Laparoscopic Sleeve Gastrectomy

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess the impact of sarcopenic obesity (SO) on weight loss outcomes and improvement of quality of life after laparoscopic sleeve gastrectomy.

Detailed Description
-----------------
Sarcopenic obesity is a state in which a lack of muscle mass and strength coexists with an increase in fat mass, and it may affect the health outcome of people with obesity after laparoscopic sleeve gastrectomy (LSG).No studies have reported differences in weight loss outcomes between patients with SO and those with non-sarcopenic obesity (NSO) after LSG. Therefore, this study aimed to systematically evaluate the differences in weight loss and quality of life (QOL) evaluation between patients with SO and NSO after LSG and provide high-level evidence-based medical evidence for the impact of SO on weight loss in the obese population and refinement of follow-up strategies.

Conditions
-----------------
Sarcopenic Obesity, Body Composition

Intervention / Treatment
-----------------
* Procedure: Laparoscopic sleeve gastrectomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Obese patients who met the indications for LSG and were followed up regularly as planned after surgery. Exclusion Criteria: incomplete critical clinical data; incomplete imaging data; insufficient follow-up data.

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sarcopenic obesity group<br>Patients who underwent LSG with FM/FFM>0.80 calculated from the cross-sectional CT image of L3 vertebra. | Procedure: Laparoscopic sleeve gastrectomy<br>* Laparoscopic sleeve gastrectomy was performed in all patients with or without SO.<br>|
| Non-sarcopenic obesity group<br>Patients who underwent LSG with FM/FFM<0.80 calculated from the cross-sectional CT image of L3 vertebra. | Procedure: Laparoscopic sleeve gastrectomy<br>* Laparoscopic sleeve gastrectomy was performed in all patients with or without SO.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| %EWL | Percentage excess weight loss is calculated as (initial weight - 6-month weight)/(initial weight - ideal weight) × 100%. | 6 month after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| %EWL | Percentage excess weight loss is calculated as (initial weight - 1-month weight)/(initial weight - ideal weight) × 100%. | 1 month after surgery | 
| %EWL | Percentage excess weight loss is calculated as (initial weight - 3-month weight)/(initial weight - ideal weight) × 100%. | 3 month after surgery | 
| %EWL | Percentage excess weight loss is calculated as (initial weight - 9-month weight)/(initial weight - ideal weight) × 100%. | 9 month after surgery | 
| %EWL | Percentage excess weight loss is calculated as (initial weight - 12-month weight)/(initial weight - ideal weight) × 100%. | 12 month after surgery | 
| %TWL | Percentage total weight loss is calculated as (initial weight - 6-month weight)/(initial weight) × 100% | 6 month after surgery | 
| %TWL | Percentage total weight loss is calculated as (initial weight - 12-month weight)/(initial weight) × 100% | 12 month after surgery | 
| EBMI | Excess BMI is calculated as(follow-up BMI - ideal BMI) | 6 month after surgery | 
| %WL | Percentage weight loss is calculated as (follow-up weight/initial weight) × 100% | 6 month after surgery | 
| MA II score | Moorhead-Ardelt QOL questionnaire is a six-item self-report questionnaire that assesses the patient's subjective impression of QOL,The total score ranges from -3 to +3 and defines five outcome groups: very poor, poor, fair, good, and very good. Good and very good outcomes were considered satisfactory. | 6 month after surgery | 
| BAROS score | The Bariatric Analysis and Reporting Outcome System(BAROS)combines the Moorhead-Ardelt QOL questionnaire with other data relevant to bariatric surgery, including the %EWL, improvement in comorbid conditions, and complications.A BAROS score ≤1 was considered a failure; >1-3, fair; >3-5, good; >5-7, very good; and >7, excellent. | 6 month after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
laparoscopic sleeve gastrectomy, weight loss, sarcopenic obesity, Fat-free mass, Quality of life