Neurological Blood-based Biomarkers and Cognitive Disorders in Critically Ill Survivors.

Study Overview
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Brief Summary
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Cognitive disorders are common after intensive care. Currently, their diagnosis is based on clinical tests. The investigators plan to study the relationship between different neurological blood biomarkers (cytokines, S100β protein, neuron specific enolase, total Tau protein and neurofilament light chain) and the occurrence of cognitive disorders during the three months following intensive care discharge.

Official Title
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The Relationship Between Neurological Blood-based Biomarkers and Mid-term Cognitive Disorders in Critically Ill Survivors.

Conditions
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Intensive Care Unit Syndrome, Post-intensive Care Syndrome, Cognitive Disorder

Intervention / Treatment
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* Other: Blood analysis
* Other: Cognitive tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Anticipated ICU stay of at least 7 days for sepsis, acute respiratory distress syndrome, severe burns French speaking Exclusion Criteria: hearing loss or blindness mental retardation known cognitive disorders or dementia ICU admission for neurological disease refusal

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| ICU survivors<br>Cohort of patients who survive an ICU stay of at least 7 days | Other: Blood analysis<br>* Blood analysis for neurological biomarkers measurements<br>Other: Cognitive tests<br>* Questionnaires assessing cognitive function<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood neurological biomarkers levels | Measurement of blood levels of S100β protein | ICU Admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of S100β protein | day 3 after ICU admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of S100β protein | day 7 after ICU admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of S100β protein | day 14 after ICU admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of S100β protein | 3 months after ICU discharge | 
| Blood neurological biomarkers levels | Measurement of blood levels of neuron specific enolase | ICU Admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of neuron specific enolase | day 3 after ICU admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of neuron specific enolase | day 7 after ICU admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of neuron specific enolase | day 14 after ICU admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of neuron specific enolase | 3 months after ICU discharge | 
| Blood neurological biomarkers levels | Measurement of blood levels of total Tau protein | ICU Admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of total Tau protein | day 3 after ICU admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of total Tau protein | day 7 after ICU admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of total Tau protein | day 14 after ICU admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of total Tau protein | 3 months after ICU discharge | 
| Blood neurological biomarkers levels | Measurement of blood levels of neurofilament light chain | ICU Admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of neurofilament light chain | day 3 after ICU admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of neurofilament light chain | day 7 after ICU admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of neurofilament light chain | day 14 after ICU admission | 
| Blood neurological biomarkers levels | Measurement of blood levels of neurofilament light chain | 3 months after ICU discharge | 
| Cognitive disorders assessment (global assessment) | Administration of the MOCA questionnaire (Montreal Cognitive Assessment) : scoring from 0 to 30, the highest score meaning the better cognitive outcome) | the day after ICU discharge | 
| Cognitive disorders assessment (global assessment) | Administration of the MOCA questionnaire (Montreal Cognitive Assessment) : scoring from 0 to 30, the highest score meaning the better cognitive outcome) | 3 months after ICU discharge | 
| Memory disorder assessment | Administration of the California Verbal Learning Test: a Z-score will be used to score this item | 3 months after ICU discharge | 
| Memory disorder assessment | Administration of the Brief Visuospatial Memory Test (a Z-score will be used to score this item) | 3 months after ICU discharge | 
| Speed of information processing assessment | Administration of the Ways IV test (a Z-score will be used to score this item) | 3 months after ICU discharge | 
| Executive function assessment | Administration of the Trail Making Test (a Z-score will be used to score this item) | 3 months after ICU discharge | 
| Memory disorder assessment | Administration of the Reading Span (working memory) test (a Z-score will be used to score this item) | 3 months after ICU discharge | 
| Executive function assessment | Administration of the Stroop Color and Word Test (a Z-score will be used to score this item) | 3 months after ICU discharge | 
| Executive function assessment | Administration of the Go/No-go test (a Z-score will be used to score this item) | 3 months after ICU discharge |