Evolution of Pulsed Oxygen Saturation During Interval Training Compared to Continuous Training in COPD Patients

Study Overview
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Brief Summary
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A problem often observed during exercise training is oxygen desaturation exclusively during exercise in some patients. In the case of exercise-induced desaturation, it may be suggested to train these patients in interval training to limit exercise-induced desaturation. Interval training consists of alternating active phases of short duration (often 30 seconds to 1 minute) followed by a short active or passive recovery phase of equivalent duration to the previous phase. Investigators therefore hypothesise that interval training on a cycloergometer or treadmill can limit exercise-induced desaturation in COPD patients. The aim of the study is to observe the evolution of pulsed oxygen saturation between a continuous training session and a interval training session.

Official Title
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Evolution of Pulsed Oxygen Saturation Throughout an Interval Training Session Compared to a Continuous Training Session in Patients With Chronic Obstructive Pulmonary Disease With Exercise-induced Oxygen Desaturation.

Conditions
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COPD, Exercise, Pulmonary Rehabilitation, Desaturation of Blood

Intervention / Treatment
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* Other: Continuous training session
* Other: Interval training session


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: a diagnosis of COPD participating in a pulmonary rehabilitation programme with an exercise-induced desaturation less than 90% no oxygen supplementation Exclusion Criteria: Under 18 years of age Pregnant woman Person not affiliated to a health insurance regime or not benefiting from a social security regime Patient under curatorship, guardianship or safeguard of justice Patient speaking a language other than French Patient with severe hypoxaemia (SpO2 ≤ 80%) during exercise Patient having had a moderate or severe exacerbation (hospitalisation for respiratory reasons) in the previous 4 weeks Patients with orthopaedic, rheumatic, vascular or neurological pathology limiting their ability to make an effort Breastfeeding women
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Continuous training session<br> | Other: Continuous training session<br>* Continuous training consists of a 5 minute warm up, 5 minute cool down and 20 minutes of moderate intensity work. The workload is set at 60% of the patient's maximum power<br>|
| Interval Training session<br> | Other: Interval training session<br>* Interval training consists of a 5-minute warm-up, a 5-minute cool-down and 20 minutes of alternating 60 seconds of high-intensity work (100% of the maximum power recorded in the incremental test that was carried out when the patient was admitted to the pulmonary rehabilitation department) and 60 seconds of unloaded pedalling or rest.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in oxygen pulsed saturation | Difference in minimum saturation during both exercise, the measurement will be performed with a pulse oximeter (Spirodoc, MIR) | One week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in oxygen pulsed saturation | Difference in mean pulsed oxygen saturation and the time spent with a pulsed oxygen saturation below 90% during the two training sessions. The measurement will be performed with a pulse oximeter (Spirodoc, MIR) | One week | 
| Difference in peripheral muscle oxygenation | Muscle oxygenation (arbitrary unit) will be evaluated using Near-infrared spectroscopy technology. the measurement will be performed with a Near Infrared spectroscopy (Portamon, Artinis Medical Systems) | One week | 
| Difference in respiratory rate | Difference in respiratory rate will be measured breath-by-breath using a portable spirometer (Spirodoc, MIR) | One week | 
| Difference in tidal volume | Difference in tidal volume will be measured breath-by-breath using a portable spirometer (Spirodoc, MIR) | One week | 
| Difference in inspiratory capacity | Difference in inspiratory capacity will be measured using a portable spirometer (Spirodoc, MIR) | One week | 
| Difference in Dyspnea | Dyspnea peak during exercise using the modified Borg scale 0-10, 0 no dyspnea, 10 maximal dyspnea | One week | 
| Difference in muscle discomfort | Muscle discomfort peak during exercise using the modified Borg scale 0-10, 0 no dyspnea, 10 maximal dyspnea | One week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COPD, Pulmonary rehabilitation, Interval training