Osteogenesis Imperfecta and Balance

Study Overview
=================
Brief Summary
-----------------
Osteogenesis Imperfecta (OI), also known as brittle bone disease, is a group of genetic disorders that mainly affect the bones. It results in bones that break easily. Its severity may be mild to severe. Other symptoms may include a blue tinge to the whites of the eye, short height, loose joints, hearing loss, breathing problems and problems with the teeth. Physiotherapy is aimed to strengthen muscles and improve motility in a gentle manner, while minimizing the risk of fracture, and the use of support cushions to improve posture.

Detailed Description
-----------------
This study aimed to assess the efficacy of Whole Body Vibration on balance and motor function in children with Osteogenesis Imperfecta. Whole body vibration (WBV) therapy is targeted at musculoskeletal strengthening and has been trialed in a variety of conditions. WBV has been shown to have therapeutic advantage in various osteopenic preclinical models and populations such as postmenopausal women (improved mobility, muscle strength, postural strength, and bone density) and children with osteogenesis imperfecta (improved mobility)

Official Title
-----------------
Efficacy of Whole Body Vibration on Balance and Motor Control in Children With Osteogenesis Imperfecta

Conditions
-----------------
Osteogenesis Imperfecta

Intervention / Treatment
-----------------
* Other: Physical Therapy Program


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Their age was ranging from six to twelve years Children participated in this study were from both sexes All children with stable medical and psychological status. They were able to follow the verbal commands or instructions during testing. Exclusion Criteria: Children with visual or auditory problems. Children with any cognitive problems. Children without deformity
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: G 1 (control) received traditional physical therapy program for 30 min. G 2 (study) received traditional physical therapy program for 15 min. and Whole Body Vibration for 15 min
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Control Group<br>Group 1 the control group received selected physical therapy program which contain strengthening exercises for upper limb and lower limb muscles, stretching exercises for elbow extensors, hand pronator, wrist extensors, knee extensors and ankle dorsiflexors, coordination and balancing exercises. | Other: Physical Therapy Program<br>* Physical Therapy Program plus Whole Body Vibration<br>|
| Experimental: Study group<br>Group 2 the study group received the same physical therapy program 15 min. plus Whole Body Vibration for 15 min. | Other: Physical Therapy Program<br>* Physical Therapy Program plus Whole Body Vibration<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Over All Stabiity Index | Stability Index | at day 0 | 
| Over All Stabiity Index | Stability Index | at day 90 | 
| Medio lateral Stabiity Index | Stability Index | at day 0 | 
| Medio lateral Stabiity Index | Stability Index | at day 90 | 
| Antro posterior Stabiity Index | Stabiity Index | at day 0 | 
| Antro posterior Stabiity Index | Stabiity Index | at day 90 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Osteogenesis Imperfecta, Whole Body Vibration, Balance, Motor Control