linjc16/ctgov huggingface dataset:
DBS and Sleep Outcomes

Study Overview
=================
Brief Summary
-----------------
The objective of this study is to describe how activation of distinct pathways in and around the subthalamic nucleus (STN) and internal segment of the globus pallidus (GPi) correlate to changes in sleep outcomes in movement disorders patients after deep brain stimulation (DBS) surgery targeting these structures.

Official Title
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Sleep Outcomes With DBS Therapy in Parkinson's Disease and Dystonia

Conditions
-----------------
Deep Brain Stimulation, Parkinson's Disease and Parkinsonism, Dystonia

Intervention / Treatment
-----------------
* Device: DBS


Participation Criteria
=================
Eligibility Criteria
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Inclusion Criteria: At least 21 years old Existing or planned 7T brain imaging Surgery at UMN to implant DBS system in GPi or STN is planned as part of routine clinical care (or has already occurred, as long as the initial programming session is at least 2 weeks away) Exclusion Criteria: Other significant neurological disorder History of dementia Patients with post-operative complications or adverse effects (e.g. ON stimulation dystonias) that affect patient safety or confound the experiment will be excluded from further study Pregnant women

Ages Eligible for Study
-----------------
Minimum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: DBS|deep brain stimulation|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pallidopeduncular and pedunculopallidal pathway activation | Percent of pallidopeduncular and pedunculopallidal pathway activation | 6 months post DBS surgery | 
| pallidopeduncular and pedunculopallidal pathway activation | Percent of pallidopeduncular and pedunculopallidal pathway activation | 12 months post DBS surgery | 
| GPe activation | percent of GPe activation | 6 months post DBS surgery | 
| GPe activation | percent of GPe activation | 12 months post DBS surgery |
Mitral Regurgitation in Hypertrophic Obstructive Cardiomyopathy: Fix it in a Simple, Effective and Durable Way!

Study Overview
=================
Brief Summary
-----------------
Septal myectomy is performed in selected cases to treat patients with hypertrophic obstructive cardiomyopathy (HOCM). The mechanism that causes obstruction involves both the outflow tract itself and the mitral apparatus, with the appearance of mitral regurgitation (MR) by SAM (Systolic Anterior Motion). When the interventricular septum is not particularly thick, isolated myectomy may not be sufficient to eliminate the SAM; in these cases the concomitant treatment of the mitral valve is considered. Different approaches have been proposed: mitral replacement with prosthesis, plication or lengthening of the anterior leaflet or the edge-to-edge (EE) technique. In addition, a small proportion of patients with HOCM may have MR from organic valve abnormalities, requiring specific treatment. Currently, there are few studies in the literature aimed at determining the role of EE in the context of HOCM; most of these studies are characterized by short follow-up or by the scarcity of echocardiographic data. The aim of the present study is to evaluate the long-term outcomes of EE associated with septal myectomy in patients with CMIO, both from a clinical point of view and by reporting echocardiographic data.

Official Title
-----------------
Mitral Regurgitation in Hypertrophic Obstructive Cardiomyopathy: Fix it in a Simple, Effective and Durable Way!

Conditions
-----------------
Hypertrophic Obstructive Cardiomyopathy, Mitral Regurgitation

Intervention / Treatment
-----------------
* Procedure: Septal myectomy and mitral valve repair with edge-to-edge technique


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diagnosis of HOCM with indication for surgery, patients operated on from 2000 to 2017 contextual diagnosis of MR needing reparative surgical treatment age ≥ 18 years Exclusion Criteria: hypertophic left ventricle due to other causes (aortic stenosis, arterial hypertension)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Septal myectomy and mitral valve repair with edge-to-edge technique|Resection of the obstructing part of the interventricular septum and mitral repair using the edge-to-edge technique (suture of leaflets free margins in the regurgitation spot)|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival time after intervention |  | through study completion, a minimum of 2 years | 
| freedom from reintervention |  | through study completion, a minimum of 2 years |
Vegetalization of the Maternal Diet During Pregnancy: Association With Pregnancy Outcomes and Newborn Health.

Study Overview
=================
Brief Summary
-----------------
Reducing consumption of animal-based foods in favor of a more plant-based diet is a major environmental, public health and economic challenge. Data on the health effects of highly vegetated diets are only available for adults. Only a few studies report on the effect of the level of vegetalization of the maternal diet during pregnancy on the mother's health, and the development and health of the child. The aim of the VEGALIM project is to describe the level of vegetalization of pregnant women's diets and the quality of their diets early in pregnancy (first trimester) and at the end of pregnancy, and to explore the potential effects on their plasma lipid profile that could impact on their health during pregnancy and the health of the newborn.

Official Title
-----------------
VEGALIM : Vegetalization of the Maternal Diet During Pregnancy: Association With Pregnancy Outcomes and Newborn Health.

Conditions
-----------------
Feeding During Pregnancy

Intervention / Treatment
-----------------
* Other: Food Frequency Questionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria : Pregnant women consulting CEMAFOER of Nantes University Hospital for pregnancy monitoring Gestational age between 11 and 13+6 days Understanding French Exclusion Criteria: Underage women Patient who objected to being included in the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pregnant women included in the VEGALIM project<br>Pregnant women consulting CEMAFOER (Center for Maternal and Fetal Pathology Screening and Risk Assessment) of Nantes University Hospital for pregnancy monitoring | Other: Food Frequency Questionnaire<br>* We will obtain a global index of vegetalization of the diet (the Plant based Diet Index: PDI) from data obtained using semi-quantitative questionnaires on food frequency (Food Frequency Questionnaire (FFQ)) validated on the national ELFE cohort (French Longitudinal Study from Childhood (https://www.elfe-france.fr)) and completed by women in the 1st trimester of pregnancy (T1).<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Characterizing the levels of plant-based food consumption at the beginning of pregnancy (at the end of the first trimester of pregnancy) based on the completion of the Food Frequency Questionnaire (FFQ, scale from 0 to 6 ; 0 being the worst outcome) |  | 45 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pregnancy, Newborn, Vegetalization, Food
Physiologic Burden to the Surgeon During Orthopaedic Surgery

Study Overview
=================
Brief Summary
-----------------
The investigator's plan to quantify the physiologic impact of orthopaedic surgery on the surgeon and operating team.

Detailed Description
-----------------
The prevalence of musculoskeletal pain among orthopaedic surgeons is inordinately high. Poor surgical ergonomics and physiological stress have been shown to impair surgical performance and cause injuries. Various approaches, techniques and instruments have been designed to improve surgical outcomes for patients. There has been nominal research in the area of occupational hazards such surgeries impose upon the surgeon. Several studies have demonstrated a higher risk of cervical spondylosis and rotator cuff tears amongst surgeons. However, little has been studied on the impacts of some of these approaches, techniques, and instruments on surgeons' physiologic measures. The investigator's will use The Hexoskin Smart Vest to capture physiological data from surgeons during the study.

Official Title
-----------------
Quantification of Physiologic Burden to the Surgeon During Orthopaedic Surgery

Conditions
-----------------
Physiological Stress

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Orthopaedic surgeons, orthaopedic fellows, and orthopaedic residents. Up to 750 surgical patients of the participating surgeons will be included for demographic chart review. Exclusion Criteria: Non-surgeons, fellows, or residents. Female participants that are or become pregnant.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Average Heart Rate (beats per minute, bpm) | Average surgeon heart rate prior to surgery. | 30 minutes before surgery | 
| Average Heart Rate (beats per minute, bpm) | Average surgeon heart rate during surgery. | During entire surgical procedure | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Surgeon, Orthopaedic surgery, Hexoskin Smart Vest, Physiologic data
Plantar Pressure Values in Patients With Ankylosing Spondylitis

Study Overview
=================
Brief Summary
-----------------
this study was discovered that clinical and radiological characteristics were related to plantar pressure assessments in patients with AS.

Detailed Description
-----------------
Determine the correlation between the plantar pressure readings of AS patients and the clinical and radiological measures utilized in the monitoring of the condition. Method: This study covered 75 participants. The quality of life was measured using ASQoL, BASMI, BASFI, and BASDAI, and demographic information was also recorded. The pedobarographic evaluations included the recording of static and dynamic plantar pressures

Official Title
-----------------
Plantar Pressure Values in Patients With Ankylosing Spondylitis and Their Relation With Clinical and Radiological Parameters

Conditions
-----------------
Device is Used for Evalution (Event)

Intervention / Treatment
-----------------
* Diagnostic Test: plantar pressure values


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients diagnosed with AS - Exclusion Criteria: Patients with cognitive dysfunction, vision loss that would prevent walking on the pedobarography platform, history of surgery and neurological deficit in the lower extremity, and patients who could not walk independently -
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: plantar pressure values|Walking enables for extremely accurate and pointwise ground response force measurement because to plantar pressure measurement (pedobarography). It allows for the objective comparison and evaluation of the dynamic pressure put on the ground by the foot in contact with it. It is often used in clinics to assess foot mechanics and associated disorders that affect the foot sole. Additionally, plantar pressure analysis is useful for identifying, treating, and monitoring conditions that impact the lower extremity's axial alignment.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pedobarographic Measurements | The cases' foot sole pressures were measured using a pedobarography device of the RsScan International brand (1m, 3D Scientific+Balance software model). This technology measures both static (when standing) and dynamic foot sole pressures (walking). The device's pressure measuring platform has an overall frame size of 1068x418x12 mm, 8192 sensors totaling 4 sensors per cm2, and a sensor area of 975x325 mm. It has a 500 Hz frequency, a 0-200 N/cm2 pressure range, a 15° to 40° C temperature range, and a 220/110 volt connecting power. | at begining |
Retrospective Study in FFPE Samples From Younger Patients With Rhabdomyosarcoma

Study Overview
=================
Brief Summary
-----------------
This retrospective study is looking into mechanisms of drug therapy resistance in FFPE samples in recurrent and refractory Rhabdomyosarcoma (RMS) in pediatric patients who have experienced lung recurrence. The study employs advanced techniques such as single-cell transcriptomics and spatial transcriptomics to gain a comprehensive understanding of these mechanisms.

Detailed Description
-----------------
This research seeks to enhance our understanding of drug resistance mechanisms in recurrent and refractory RMS in pediatric patients, particularly in the context of lung recurrence. The utilization of cutting-edge techniques like single-cell transcriptomics and spatial transcriptomics allows for a more in-depth and comprehensive analysis of the molecular and spatial aspects of drug resistance in this challenging pediatric cancer.

Official Title
-----------------
Mechanism of Children With Relapsed and Refractory Rhabdomyosarcoma (RMS)

Conditions
-----------------
Alveolar Childhood Rhabdomyosarcoma, Embryonal Childhood Rhabdomyosarcoma, Recurrent Childhood Rhabdomyosarcoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pediatric Patients: Participants in this study should be pediatric patients, typically defined as individuals aged from infancy to 18 years old, who have been diagnosed with recurrent and refractory Rhabdomyosarcoma (RMS). Lung Recurrence: Included patients must have a documented history of lung recurrence of RMS as a specific clinical manifestation. Availability of FFPE Samples: Patients for whom formalin-fixed paraffin-embedded (FFPE) tissue samples are available for analysis are eligible for inclusion. Exclusion Criteria: Other Histological Types: Patients with RMS of histological subtypes other than those relevant to the study focus are excluded. Incomplete Clinical Data: Patients with incomplete or insufficient clinical data necessary for the study's objectives may be excluded to ensure robust analysis and interpretation of results.

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gene expression pattern | Identification and characterization of specific genetic alterations and gene expression patterns associated with drug therapy resistance in recurrent and refractory Rhabdomyosarcoma (RMS) in pediatric patients, particularly in cases of lung recurrence, using single-cell transcriptomics and spatial transcriptomics. | 2023.12.31 |
Evaluation of the Consequences of Poly Vaccination on Innate Immunity : Applications to a Military Population

Study Overview
=================
Brief Summary
-----------------
In this study, the poly vaccination of military personnel prior to deployment will be analyzed in terms of central, peripheral and long-lasting changes in innate immunity. Analysis of monocyte immune training induced by vaccination will provide a better understanding of the indirect effects of vaccination and their persistence over time.

Official Title
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VaxInnate : Evaluation of the Consequences of Poly Vaccination on Innate Immunity : Applications to a Military Population

Conditions
-----------------
Vaccine Breakthrough Infections

Intervention / Treatment
-----------------
* Other: Blood and saliva sampling
* Other: Survey


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: french military personnel >18yo overseas deployment scheduled between 30 and 60 days after vaccination session adult able to give consent Exclusion Criteria: unrectified military personnel having received a live vaccine within 6 months prior to inclusion having received an attenuated vaccine within 3 months prior to inclusion pregnancy or breastfeeding vaccine contraindication major incapacity

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sampling and survey group<br>This group will complete questionnaires and participate in sample collection. | Other: Blood and saliva sampling<br>* Collecting blood and saliva sample<br>Other: Survey<br>* Collecting data on infectious diseases during the study period<br>|
| Survey group<br>This group will only complete questionnaires | Other: Survey<br>* Collecting data on infectious diseases during the study period<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Monocytes' functional reprogramming | describing the functional reprogramming of monocytes following vaccination sessions among military personnel prior and after deployment | 11 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identify immune signatures | Identifying immune signatures by comparing the functional reprogramming of monocytes by different vaccines and co vaccinations schemes | 11 months | 
| Time persistence | Assess the persistence over time of the effects by follow-up after return from mission | 11 months |
A Clinical Study Aims to Assess the Consistency of Clinical Efficacy in Gastric Cancer Treatment and Drug Susceptibility Outcomes Using a Novel Drug Susceptibility Testing Method

Study Overview
=================
Brief Summary
-----------------
The study is a real-world observational clinical study. Patients diagnosed as gastric cancer through histopathology were screened and enrolled. Before anti-tumor treatment, gastroscopy biopsy tissue specimens, surgical specimens, and malignant pleural effusion or ascites specimens, etc. are collected. The investigators will perform a drug sensitivity testing based on a novel drug susceptibility testing method to test the commonly used anti-tumor treatment regimens. Patients were given conventional anti-tumor treatment according to the medical judgment of the doctors. Finally, the investigator will evaluate the consistency of clinical efficacy in gastric cancer treatment and drug susceptibility outcomes.

Official Title
-----------------
A Real-world Observational Clinical Study Aims to Assess the Consistency of Clinical Efficacy in Gastric Cancer Treatment and Drug Susceptibility Outcomes Using a Novel Drug Susceptibility Testing Method

Conditions
-----------------
Gastric Cancer, Organoids

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female, aged ≥ 18 and ≤80; Patients with gastric cancer diagnosed by histopathology; Patients who need neoadjuvant treatment; adjuvant therapy after radical surgery or palliative treatment; Fresh tumor tissue specimens or malignant pleural effusion or ascites can be obtained; Patients who sign the informed consent form, and are able to comply with the study period treatment process. Exclusion Criteria: Inability to follow the research protocol; Inability to obtain relevant fresh specimens by biopsy/surgery/puncture; Concomitant contraindications to chemotherapy; pregnant or lactating women; Patients deemed inappropriate by investigators.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disease-free survival | An Indicator of efficacy of postoperative adjuvant therapy | From date of surgery until the date of first documented recurrence，up to 3 years | 
| Sensitivity | Cases in which drug susceptibility results are sensitive to the antineoplastic regimen as a percentage of the cases that are effective in clinical evaluation | Through study completion, an average of 1 year | 
| Specificity | Cases in which drug susceptibility results are resistance to the antineoplastic regimen as a percentage of the cases that are ineffective in clinical evaluation | Through study completion, an average of 1 year |