Carotid Artery Corrected Flow Time and Fluid Responsiveness in Geriatric Patients

Study Overview
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Brief Summary
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Carotid blood flow and corrected carotid flow time (Carotid Flow Time (FTc)) provide information about left ventricular preload and inversely correlate with systemic vascular resistance. The reliability in assessing fluid responsiveness has been demonstrated in studies involving invasive cardiac output measurements. In the elderly patient population where arterial elasticity can be compromised, there is no existing data in literature that determines the reliability and predictive value of FTc after general anesthesia induction.

Detailed Description
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Doppler ultrasound of the common carotid artery has begun to be used as a potential non-invasive tool for assessing hemodynamic status. Its non-invasive nature, ability to be applied independently of the patient's position, ease of application due to the superficial location of the carotid artery, and resistance to intrathoracic pressure changes are among its advantages. Carotid blood flow and corrected carotid flow time (Carotid Flow Time (FTc)) provide information about left ventricular preload and inversely correlate with systemic vascular resistance. Additionally, the velocity time integral (VTI) measuring blood flow through the carotid artery during systole, when multiplied by the cross-sectional area of the carotid artery, allows for the determination of flow within the carotid artery. The reliability in assessing fluid responsiveness has been demonstrated in studies involving invasive cardiac output measurements. In the elderly patient population where arterial elasticity can be compromised, there is no existing data in literature that determines the reliability and predictive value of FTc after general anesthesia induction.

Official Title
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Reliability of Carotid Artery Corrected Flow Time Predicting Fluid Responsiveness in Geriatric Patients.

Conditions
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Fluid Responsiveness, Common Carotid Artery

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: geriatric patient (older than 65 years of age) having surgery under general anesthesia Exclusion Criteria: Common carotid artery stenosis, common carotid artery disease

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Fluid responsive<br>A 15% increase in cardiac output following a fluid challenge ( 6ml/kg crystalloid solution infusion in 30 min). Carotid corrected flow time measured before and after fluid challenge by ultrasound. | |
| Fluid non-responsive<br>Failure of 15% increase in cardiac output following a fluid challenge ( 6ml/kg crystalloid solution infusion in 30 min). Carotid corrected flow time measured before and after fluid challenge by ultrasound. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| carotid corrected flow time (cFT) | the ability ofc FT to predict fluid responsiveness | 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cutt-of value of cFT | the cutt-of value of cFT to predict fluid responsiveness | 1 hour | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fluid responsiveness, carotid blood flow, carotid corrected flow time