Short-term Evaluation of Motor and Sensory Function in Post-COVID-19 Patients

Study Overview
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Brief Summary
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SARS-COV-2 infection reframed medical knowledge in many aspects, yet there is still a lot to be discovered. our aim is to evaluate neurological impact of covid-19; if there is any.

Detailed Description
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Coronavirus disease 19 (COVID-19) can cause neuropsychiatric, psychological and psychosocial impairments. Literature regarding the sensory and motor affection of COVID-19 is still limited. Public health emergencies as COVID-19 are likely to cause adverse neuropsychiatric impacts. Cognitive impairments after SARS-COV-2 infection were noticed, COVID-19 patients complain of poor concentration, declined memory, and insomnia, as well as anxiety and depression symptoms. in a study; Neurological manifestations described in 36.4% of 214 patients with confirmed COVID-19. However, the symptoms described [dizziness (not further defined), headache, and impaired consciousness] are commonplace in many severe infections and represent disturbances in neurological function rather than a neurological disease per se. Anosmia and ageusia have received much attention, but are ubiquitous in other common upper respiratory tract infections. While a reported increased risk of cerebrovascular disease.

Official Title
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Short-term Evaluation of Motor and Sensory Function in Post-COVID-19 Patients

Conditions
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Motor Neuropathy, Sensory Neuropathy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with confirmed RT-PCR COVID-19 infection with mild to moderate severity based on the Egyptian ministry of health (MOH) protocol (version 1.4, November 2020) with neurological symptoms suggestive of peripheral neuropathy Exclusion Criteria: patients presenting with neurological manifestations other than peripheral neuropathy, such as stroke, cerebral hemorrhage, encephalitis, or meningitis. Patients with any medical condition or comorbidities that may affect the result of the study as diabetes, arthritis, and carpel tunnel syndrome. Severe COVID-19 patients with a critical condition that needs hospitalization and ventilatory support were also excluded from the study.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 68 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Covid-19 Group<br>Motor nerve study was performed in the median and posterior tibial nerve to assess the motor function of the upper and lower limbs. Sensory nerve study was done for the median and sural nerves to estimate the peripheral neurological function of both upper and lower limbs. F wave study was performed for the upper limb in the median nerve. | |
| Control Group<br>Motor nerve study was performed in the median and posterior tibial nerve to assess the motor function of the upper and lower limbs. Sensory nerve study was done for the median and sural nerves to estimate the peripheral neurological function of both upper and lower limbs. F wave study was performed for the upper limb in the median nerve. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Motor nerve function | The motor nerve study was performed in the median and posterior tibial nerve to assess the motor function of the upper and lower limbs; included Compound motor action potential (CMAP), Motor nerve conduction velocity (MNCV), and nerve conduction latency recording. | 1 MONTH | 
| Sensory nerve function | The sensory nerve study was done for the median and sural nerves including Sensory motor nerve conduction amplitude, latency, and velocity were recorded. | 1 MONTH | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Covid-19, Nerve conduction studies, Neuropathy, Complication