The Impact of Preoperative Supplementation of Zinc

Study Overview
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Brief Summary
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Pre operative anthropometric assessment including : weight in kg, height/length and BMI Pre operative Zinc supplementation (dose according to the age) for 7 days preoperatively for cases Postoperative data collection

Detailed Description
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Postoperative data collection : Length of hospital stay Complication and sorting of them Lab withdrawal of inflammatory markers on 2-3 day postoperatively

Official Title
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The Impact of Preoperative Supplementation of Zinc on Post-operative Outcomes in Children Undergoing Elective Surgery for Hirsch Sprung Disease

Conditions
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Surgery, Nutrition Disorders

Intervention / Treatment
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* Dietary Supplement: Zinc


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All children patients with Hirschsprung disease admitted for surgical intervention with different ( age , sex ) Type of surgery : transanal pull through Whose parents or caregivers approve for the participation in the study Exclusion Criteria: Patients with emergency situations Whose parents or caregivers will not apply for the participation in the study

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Interventional<br>25 children diagnosed with Hirschsprung disease and planned for elective surgery will be supplemented with Zinc 7 days before the operation . Outcomes will be evaluated thorugh measuring the hospital length stay. Other parameters including inflammatory markers as CRP , CRP /albumin ratio and development of postoperative complications will be assesed and compared between cases and controls | Dietary Supplement: Zinc<br>* Zinc Supplementation<br>|
| No Intervention: Control<br>25 children diagnosed with Hirschsprung disease and planned for elective surgery will recieve the standard care provided for the cases and will not be supplemented with Zinc . Outcomes will be evaluated thorugh measuring the hospital length. Other parameters including inflammatory markers as CRP , CRP /albumin ratio and development of postoperative complications will be assesed and compared between cases and controls | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The effect of preoerative Zinc supplementation on the hospital length stay in children operated for Hirschsprung's disease | Children oprated for elective surgery for Hirschsprung's disease will be supplemented with zinc seven days before surgery and postoperative data as the duration of hospital length stay in hours will be meausred in both the cases and control groups and comapred. | zinc supplemenation for one week |