Low-Level Laser Effects on Orthodontic Tooth Movement of Periodontally Compromised Patients.

Study Overview
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Brief Summary
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To investigate the effect of Low Level Laser therapy on orthodontic tooth movement of periodontally compromised patients by evaluating the rate of orthodontic tooth movement and the level of Osteocalcin in the gingival crevicular fluid.

Detailed Description
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Low-Level laser therapy has been reported as an effective adjunct to non surgical periodontal treatment for inflammation control and tissue reparation in patients with periodontitis. Previous studies have shown that application of low-level laser therapy reduced pocket depth and decreased the inflammatory process through regulatory control of inflammatory cytokines level, therefore this study will investigate the effect of low-level laser on the periodontal tissue .Accelerating orthodontic tooth movement is one of the primary demand in orthodontics to prevent side effects as root resorption, caries and decreased patient compliance . Numerous researchers have also studied the use of LLLT in accelerating orthodontic tooth movement and have considered the laser to be effective while others achieved the opposite . Hence, This study is aiming to investigate the effects of LLLT in accelerating tooth movement.

Official Title
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Low-Level Laser Effects on Orthodontic Tooth Movement of Periodontally Compromised Patients. Clinical and Biochemical Study

Conditions
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Periodontal Diseases, Cancer Metastatic, Orthodontic Tooth Movement

Intervention / Treatment
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* Device: Biolase ;Low Level Laser


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: No systemic disease. No history medication (antibiotics and/or anti inflammatory) in the previous 4 months. Self motivated patients with acceptable oral hygien. Exclusion Criteria: Previous orthodontic treatment Aggressive periodontitis Smokers pregnant patients

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: ten patients with periodontally affected teeth subjected to low level laser therapy
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Periodontally compromised patients subjected to low level laser therapy<br>periodontally compromised patients with pocket depth of more than 5 mm before receiving nonsurgical periodontal treatment treatment or/and pocket depth of less than 4 mm with periodontal status identified as stable for at least 3 month after nonsurgical periodontal treatment subjected to low-level laser of 940 nm will be applied at day one after start of treatment , weekly during the first month, then monthly. | Device: Biolase ;Low Level Laser<br>* Low Level laser ,940 nm<br>* Other names: Biolase;|
| No Intervention: Periodontally compromised patients<br>periodontally compromised patients with pocket depth of more than 5 mm before receiving nonsurgical periodontal treatment treatment or/and pocket depth of less than 4 mm with periodontal status identified as stable for at least 3 month after nonsurgical periodontal treatment. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of orthodontic tooth movement | Rate of mandibular canine retraction | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Osteocalcin level in GCF | Gingival Crevicular Fluid samples will be collected from al target teeth in both groups to detect osteocalcin level after start of orthodontic treatment and at the end of the study | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Rate of orthodontic tooth movement, Osteiocalsine