Screening of Septo-optic Dysplasia During a Fetal Examination at 16-20 Weeks of Gestation

Study Overview
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Brief Summary
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Evaluation of prenatal optic chiasm (OC) is important for the differential diagnosis of septo-optic dysplasia (SOD), which is a congenital optic disc anomaly, and the absence of the cavum septum pellucidum (CSP). Septo-optic dysplasia is associated with a wide range of neurological abnormalities, including hypoplasia of the visual pathways, CSP agenesis, and developmental delay.

Detailed Description
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Up to now, optic chiasm measurement were all done in the third trimester. in the present study, OC will be measure directly in a 2D ultrasound in coronal plane within the second trimester. In fetuses with SP agenesis, the morphology and width of the OC visual pathway may be a suitable tool to assess its development. It can also assist in the difficult task of providing prenatal counseling when faced with a diagnosis of CP agenesis. therefore In the present study, it was planned to show the optic chiasm in the screening of septooptic dysplasia by ultrasound between 16-20 weeks of gestation, and to measure the optic chiasma width and length, and to determine the mean values in the second trimester.

Official Title
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Screening of Septo-optic Dysplasia During a Fetal Examination at 16-20 Weeks of Gestation

Conditions
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Cavum Septum Pellucidum, Optic Chiasma, 2D Ultrasound, Septooptic Dysplasia, Willis Polygon

Intervention / Treatment
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* Diagnostic Test: Displaying optic chiasm for screening septooptic dysplasia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: aged greater than 18 years old having singleton pregnancy Exclusion Criteria: being under the age of 18 having IVF pregnancy having multiple pregnancy comorbidity during pregnancy smoking history presence of familial genetic disease

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Screening septooptic dysplasia<br>Displaying and measuring the width and length of the optic chiasm for screening septooptic dysplasia | Diagnostic Test: Displaying optic chiasm for screening septooptic dysplasia<br>* Displaying and measuring the width and length of the optic chiasm for screening septooptic dysplasia with ultrasound between 16-20 weeks of gestation<br>* Other names: Measuring the width and length of the optic chiasm for screening septooptic dysplasia;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Calculation of average width of OC according to gestational week in millimeter |  | 2 months | 
| Calculation of average height of OC according to gestational week in millimeter |  | 2 months | 
| Calculation of average area of OC according to gestational week millimeter square |  | 2 months |