Movement Disorders in Multiple Sclerosis Patients

Study Overview
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Brief Summary
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The aim of this study is to determine the prevalence of movement disorders in MS patients. Also,To know the clinical type of movement disorders occurring with multiple sclerosis patients and the MRI finding of those patients. Moreover, to find the correlation between the movement disorder and the different types of MS.

Detailed Description
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A randomized cross-sectional study will be conducted on diagnosed multiple sclerosis patients who were diagnosed according to McDonald criteria of MS 2017 (Thompson et al. 2018). The investigators will study the prevalence of movement disorders in M.S patients, clinical type of movement disorder and the MRI findings. Data collected from patients admitted or following at Al-Azhar university hospitals at Al-Hussein and El-Sayed Galal hospitals. The included eligible patients should fulfil the following inclusion criteria: i. Full clinical history and neurological assessment. ii. Detailed multiple sclerosis history according to MS unit history sheet. iii. Detailed history of movement disorder which include clinical type of movement disorder and medication taken (or not). iv. MRI Brain and spine of the included patient will be photographed. Exclusion criteria: Patients with multiple sclerosis mimics which can cause movement disorders e.g., systemic disease or overlap syndromes including systemic lupus, vasculitis, hepatic failure, renal failure, hyperthyroidism, electrolyte disturbances, Behcet's disease or CNS infection. patients with primary movement disorders or related to other neurodegenerative diseases.

Official Title
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Clinical and Radiological Evaluation of Movement Disorders in Multiple Sclerosis Patients.

Conditions
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Multiple Sclerosis, Movement Disorders

Intervention / Treatment
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* Other: Screen for movement disorder and correlates it with MRI findings.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - We will study the prevalence of movement disorders in M.S patients, clinical type of movement disorder and the MRI findings. Data collected from patients admitted or following at Al-Azhar university hospitals at Al-Hussein and El-Sayed Galal hospitals. The included eligible patients should fulfil the following inclusion criteria: i. Full clinical history and neurological assessment. ii. Detailed multiple sclerosis history according to MS unit history sheet. iii. Detailed history of movement disorder which include clinical type of movement disorder and medication taken (or not). iv. MRI Brain and spine of the included patient will be photographed. Exclusion Criteria: - 1-Patients with multiple sclerosis mimics which can cause movement disorders e.g., systemic disease or overlap syndromes including systemic lupus, vasculitis, hepatic failure, renal failure, hyperthyroidism, electrolyte disturbances, Behcet's disease or CNS infection. 2-patients with primary movement disorders or related to other neurodegenerative diseases.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Multiple sclerosis patients with movement disorders.<br>A randomized cross-sectional study will be conducted on diagnosed multiple sclerosis patients who were diagnosed according to McDonald criteria of MS 2017 (Thompson et al. 2018). We will study the prevalence of movement disorders in M.S patients, clinical type of movement disorder and the MRI findings. Data collected from patients admitted or following at Al-Azhar university hospitals at Al-Hussein and El-Sayed Galal hospitals. The included eligible patients should fulfil the following inclusion criteria: i. Full clinical history and neurological assessment. ii. Detailed multiple sclerosis history according to MS unit history sheet. iii. Detailed history of movement disorder which include clinical type of movement disorder and medication taken (or not). iv. MRI Brain and spine of the included patient will be photographed. | Other: Screen for movement disorder and correlates it with MRI findings.<br>* To determine the prevalence of movement disorders in MS patients. To know the clinical type of movement disorders occurring with multiple sclerosis patients and the MRI finding of those patients. To find the correlation between the movement disorder and the different types of MS.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine the prevalence of movement disorders in MS patients. | To know the percentage of occurance of movement disorders in MS patients. | Through study completion, an average of 1.5 year | 
| know the clinical type of movement disorders occurring with multiple sclerosis patients and the MRI finding of those patients. | To know the specific semiology for each movement disorder. | Through study completion, an average of 1.5 year | 
| find the correlation between the movement disorder and the different types of MS. | To know if there is a correlation between the movement disorder and the different types of MS. | Through study completion, an average of 1.5 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Multiple sclerosis, Movement Disorders