Oxycodone in Combination With Parathoracic Nerve Block is Used for Postoperative Analgesia in Lung Cancer

Study Overview
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Brief Summary
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In this study, the effect of oxycodone combined with ultrasound-guided paravertebral nerve block on the postoperative analgesic effect of thoracoscopic lung cancer was investigated, and the effect and reasonable dose of oxycodone were explored, which provided a reference for the clinical multimodal analgesia after thoracoscopic lung cancer surgery.

Official Title
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Effect of Oxycodone Combined With Ultrasound Guided Thoracic Paravertebral Nerve Block on Postoperative Analgesia in Patients With Lung Cancer Undergoing Thoracoscopic Surgery

Conditions
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Oxycodone

Intervention / Treatment
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* Drug: Oxycodone 1mg/kg
* Drug: Oxycodone 1.5mg/kg
* Drug: Sufentanil


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female, age > 60 years Patients undergoing thoracoscopic lobectomy ASA (American Academy of Anesthesiologists) Grades I-III There were no obvious abnormalities in heart, liver, and kidney function Sign the informed consent form for this clinical study Exclusion Criteria: History of oxycodone or sufentanil allergy Renal or hepatic dysfunction History of drug or alcohol abuse Psychiatric disorders: schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis Those who have difficulty communicating due to coma, severe dementia, speech barrier, or those who cannot cooperate due to other diseases. People with head trauma or other brain diseases -

Ages Eligible for Study
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Minimum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Test group 1(OCA group)<br> | Drug: Oxycodone 1mg/kg<br>* Test group 1 (OCA group):oxycodone 1mg/kg + flurbiprofen 50mg + ondansetron 16mg + 0.9% normal saline diluted to 100ml<br>* Other names: Oxycodone;|
| Experimental: Test group 2(OCB group)<br> | Drug: Oxycodone 1.5mg/kg<br>* Test group 2 (OCB group): oxycodone 1.5mg/kg + flurbiprofen 50mg + ondansetron 16mg + 0.9% normal saline diluted to 100ml.<br>|
| Active Comparator: Control group(SF group)<br> | Drug: Sufentanil<br>* Control group (SF group): sufentanil 2ug/kg + flurbiprofen + ondansetron 16mg + 0.9% normal saline diluted to 100ml.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The main indicators were NRS scores at rest and cough at 24 h postoperatively. | NRS (numerical rating scale) is composed of 11 numbers from 0 to 10, and patients use 11 numbers from 0 to 10 to describe the intensity of pain, and the higher the number, the more severe the pain. | at 24h after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to double-lumen tracheal extraction | Time to double-lumen tracheal extraction | Within two hours after surgery | 
| NRS score at rest and cough | NRS (numerical rating scale) is composed of 11 numbers from 0 to 10, and patients use 11 numbers from 0 to 10 to describe the intensity of pain, and the higher the number, the more severe the pain. | at 2h , 4h, 12h, 48h after surgery | 
| sedation score (Ramsay sedation score) | The Ramsay sedation score is the most widely used sedation scoring criterion in clinical practice. It is divided into six levels, reflecting three levels of wakefulness and three levels of sleep. The higher the level, the deeper the level of sedation. | at 2 h , 4 h , 12 h ,24 h,48 h postoperatively | 
| sufentanil consumption | sufentanil consumption | Within 48 hours after surgery | 
| oxycodone consumption | oxycodone consumption | Within 48 hours after surgery | 
| analgesic pump compressions | analgesic pump compressions | Within 48 hours after surgery | 
| additional analgesic doses | additional analgesic doses | Within 48 hours after surgery | 
| incidence of adverse reactions: nausea, vomiting, respiratory depression, dizziness, itchin | incidence of adverse reactions: nausea, vomiting, respiratory depression, dizziness, itchin | Within 48 hours after surgery | 
| gastrointestinal recovery (exhaust time) | gastrointestinal recovery (exhaust time) | Within 48 hours after surgery | 
| laboratory results of C-reactive protein 1 day before and after surgery | laboratory results of C-reactive protein 1 day before and after surgery | Within 48 hours after surgery | 
| laboratory results of interleukin-6 laboratory test 1 day before and after surgery | laboratory results of interleukin-6 laboratory test 1 day before and after surgery | Within 48 hours after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Oxycodone, Postoperative analgesia, lung cancer, thoracic paravertebral nerve block