Oral Supplementation of Astaxanthin on Skin Photoaging, Hydration and Elasticity

Study Overview
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Brief Summary
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This study is a double-blind placebo controlled study to assess whether oral astaxanthin can improve skin hydration, skin elasticity, improve skin pigmentation, and reduce facial redness.

Official Title
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Double Blind Placebo Controlled Oral Supplementation of Astaxanthin on Skin Photoaging, Hydration and Elasticity

Conditions
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Photoaging

Intervention / Treatment
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* Dietary Supplement: Astaxanthin 6 mg daily
* Dietary Supplement: Placebo


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Females who are 30 to 55 years of age Half of the women will have Fitzpatrick skin type 1-3 and the other half of the women will have Fitzpatrick skin type 4-6 Exclusion criteria: Individuals with a known allergy to astaxanthin or other carotenoids (such as zeaxanthin, lutein, lycopene). Individuals who are unwilling to discontinue carotenoid supplementation for at least 1 month prior to enrollment Individuals unwilling to restrict intake of foods like shrimp, salmon, mangos, carrots, and tomatoes during the study. New supplementation within 4 weeks with tocopherol Individuals who are unwilling to stay consistent with a facial cleansing regimen. Those who are unwilling to discontinue topical hydroquinone, retinoid or benzoyl peroxide for 2 weeks prior to enrollment Individuals who are pregnant or breastfeeding. Individuals who have changed any of their hormonal based contraception within 3 months prior to joining the study. Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Astaxanthin vs Placebo
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Astaxanthin<br>6 mg daily | Dietary Supplement: Astaxanthin 6 mg daily<br>* Astaxanthin at 6 mg is given for daily ingestion and compared against placebo.<br>|
| Placebo Comparator: Placebo<br> | Dietary Supplement: Placebo<br>* Placebo<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Skin Hydration | Skin hydration measured with a non-invasive device, SkinMoistureMeterSC | 8 weeks | 
| Skin elasticity | Skin elasticity measured with a non-invasive device, Skin Elastimeter | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Facial pigmentation | Facial pigment as measured by BTBP facial imaging analysis | 8 weeks | 
| Facial redness | Facial pigment as measured by BTBP facial imaging analysis | 8 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hydration, Elasticity, Carotenoid, Astaxanthin, Skin