Mesotherapy in the Treatment of Chronic Migraine

Study Overview
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Brief Summary
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Mesotherapy is a type of injection frequently used in clinics. It is a treatment procedure that involves the injection of some drugs under the skin or into the skin. Mesotherapy is used in musculoskeletal system diseases, but it is reported that the effects of its use in migraine are uncertain.

Detailed Description
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Migraine is one of the types of headaches. For the diagnosis of chronic migraine, the headache must last more than 15 days. Nerve blocks, oral medication and neuromodulation are recommended for migraine treatment.Mesotherapy is a type of injection frequently used in clinics. It is a treatment procedure that involves the injection of some drugs under the skin or into the skin. Mesotherapy is used in musculoskeletal system diseases, but it is reported that the effects of its use in migraine are uncertain. This study was planned to show the effectiveness of mesotherapy in patients with migraine.

Official Title
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The Effectiveness of Mesotherapy (Lidocaine and Proxicam) in the Treatment of Chronic Migraine

Conditions
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Chronic Migraine, Headache

Intervention / Treatment
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* Drug: Lidocain


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - Clinical diagnosis of chronic migraine disease Exclusion Criteria: Infection disease Thyroid disease Anemia disease Systemic disease

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: Retrospective analysis of the group that received treatment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: mesotherapy<br>All participants who received mesotherapy were monitored regularly for the following three months to assess their prognosis and ensure patient adherence to treatment. | Drug: Lidocain<br>* All participants treated with procaine and lidocaine injection for treatment.<br>* Other names: Proxicam;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual Analog Scale (VAS) | VAS rates pain on a scale of zero to 10. It is explained to the participant that 10 points means unbearable pain, zero points means no pain, and the patient is asked to rate his pain between zero and ten. Higher scores indicate increased pain severity | Baseline | 
| Visual Analog Scale (VAS) | VAS rates pain on a scale of zero to 10. It is explained to the participant that 10 points means unbearable pain, zero points means no pain, and the patient is asked to rate his pain between zero and ten. Higher scores indicate increased pain severity | 4th week | 
| Visual Analog Scale (VAS) | VAS rates pain on a scale of zero to 10. It is explained to the participant that 10 points means unbearable pain, zero points means no pain, and the patient is asked to rate his pain between zero and ten. Higher scores indicate increased pain severity | 8th week | 
| Visual Analog Scale (VAS) | VAS rates pain on a scale of zero to 10. It is explained to the participant that 10 points means unbearable pain, zero points means no pain, and the patient is asked to rate his pain between zero and ten. Higher scores indicate increased pain severity | 12 th week | 
| The frequency of painful days per month | The participant is asked how many days she/he feels pain in a month.Higher numbers indicate increased frequency of painful days | Baseline | 
| The frequency of painful days per month | The participant is asked how many days she/he feels pain in a month.Higher numbers indicate increased frequency of painful days | 4th week | 
| The frequency of painful days per month | The participant is asked how many days she/he feels pain in a month.Higher numbers indicate increased frequency of painful days | 8th week | 
| The frequency of painful days per month | The participant is asked how many days she/he feels pain in a month.Higher numbers indicate increased frequency of painful days | 12th week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of attack per month | The participant is questioned about how long each attack lasts within a month. Increased periods indicate prolonged symptom duration. | Baseline | 
| Duration of attack per month | The participant is questioned about how long each attack lasts within a month. Increased periods indicate prolonged symptom duration. | 4th week | 
| Duration of attack per month | The participant is questioned about how long each attack lasts within a month. Increased periods indicate prolonged symptom duration. | 8th week | 
| Duration of attack per month | The participant is questioned about how long each attack lasts within a month. Increased periods indicate prolonged symptom duration. | 12th week | 
| the number of analgesic per month | The participant is asked how many times he/she uses analgesic medication in a month. Higher numbers indicate an increased need for medical treatment | Baseline | 
| the number of analgesic per month | The participant is asked how many times he/she uses analgesic medication in a month. Higher numbers indicate an increased need for medical treatment | 4th week | 
| the number of analgesic per month | The participant is asked how many times he/she uses analgesic medication in a month. Higher numbers indicate an increased need for medical treatment | 8th week | 
| the number of analgesic per month | The participant is asked how many times he/she uses analgesic medication in a month. Higher numbers indicate an increased need for medical treatment | 12th week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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pain, Mesotherapy, Chronic Migraine, muscle, headache