Application of Different Modes of Esketamine Administration in Pediatric Day Circumcision

Study Overview
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Brief Summary
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To explore the application of different administration modes of esketamine in pediatric day circumcision, in order to find an anesthesia scheme more suitable for day pediatric circumcision.

Detailed Description
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The current clinical study believes that esketamine is suitable for pediatric anesthesia because of its advantages of light respiratory depression, low secretions, low incidence of psychomotor reactions and fast recovery of anesthesia, but there are few related studies on its administration mode and timing in clinical application, this study aims to explore the application of different administration methods of esketamine in pediatric day circumcision, and find an anesthesia scheme more suitable for day circumcision, in order to provide new ideas for anesthesia for pediatric day circumcision.

Official Title
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Application of Different Modes of Esketamine Administration in Pediatric Day Circumcision

Conditions
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Pain

Intervention / Treatment
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* Drug: Esketamine of single injection
* Drug: Esketamine of Intermittent injection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Society of Anesthesiologists (ASA) class I and II children Age 5-12 years Foreskin cerclage is proposed No history of upper respiratory tract infection in the past two weeks Obtain the consent of the child's family Exclusion Criteria: Hepatic and renal insufficiency, coagulation dysfunction Those who are allergic to esketamine History of cognitive impairment epilepsy other psychiatric and neurological disorders

Ages Eligible for Study
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Minimum Age: 6 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: single group<br>give esketamine 0.75 mg/kg at the time of induction | Drug: Esketamine of single injection<br>* Single group: give esketamine 0.75 mg/kg at the time of induction<br>* Other names: A single injection of esketamine at the time of anesthesia induction;|
| Experimental: intermittent group<br>give esketamine 0.5mg/kg during anesthesia induction, and during the measuring ring esketamine 0.25mg/kg was given again | Drug: Esketamine of Intermittent injection<br>* Intermittent group: give esketamine 0.5mg/kg during anesthesia induction, and during the measuring ring esketamine 0.25mg/kg was given again<br>* Other names: A Intermittent injection of esketamine at the time of anesthesia induction;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| One-time success rate of anesthesia | No movement during anesthesia | During surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Systolic blood pressure | Systolic blood pressure | During surgery | 
| Diastolic blood pressure | Diastolic blood pressure | During surgery | 
| Heart rate | Heart rate | During surgery | 
| intraoperative propofol dosage, esketamine dosage | intraoperative propofol dosage, esketamine dosage | During surgery | 
| Duration of surgery | Duration of surgery | During surgery | 
| Time to open eyes | Time to open eyes | During surgery | 
| Time to talk | Time to talk | During surgery | 
| VAS(visual analogue scale) score | A score to assess pain, use a swimming ruler about 10 cm long, marked with 10 scales on one side, with 0 and 10 ends at each end, 0 points means no pain, and 10 points represent the most severe pain that is unbearable. | 12 hours after the end of surgery | 
| Incidence of adverse effects (hypotension, hypertension, respiratory depression, postoperative pain, diplopia, mania) | Incidence of adverse effects (hypotension, hypertension, respiratory depression, postoperative pain, diplopia, mania) | 12 hours after the end of surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pediatric circumcision, Mode of administration, Day surgery, Esketamine