Construction of Gynecological Tumor Organoids

Study Overview
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Brief Summary
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This study focuses on the construction of a biological sample library for organoids and tumor tissues in gynecological tumors.

Detailed Description
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Explore the construction and maintenance of a large-scale queue of gynecological tumor organoids. Beijing Daxiang Technology Co., Ltd. provides corresponding technical support and chip design. Gynecological oncology center provides tumor samples, clinical information, and pathological support, and biological sample library provides technical support, storage space, and quality management.

Official Title
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Construction of Gynecological Tumor Organoids

Conditions
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Gynecologic Cancer, Organoid

Intervention / Treatment
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* Other: construction of organoids from gynecological tumor


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age of 18 or older, an informed consent form is provided; The preoperative tumor burden assessment and intraoperative researcher team believe that sampling is feasible; Having relevant requirements for sample library storage; Surgical treatment at Peking Union Medical College Hospital. Exclusion Criteria: Unable to meet all inclusion criteria; The research team considers any situations or considerations that may hinder normal pathological assessment.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cohort of cervical cancer organoids<br>organoids derived from cervical cancer | Other: construction of organoids from gynecological tumor<br>* organoids construction<br>|
| cohort of endometrial cancer organoids<br>organoids derived from endometrial cancer | Other: construction of organoids from gynecological tumor<br>* organoids construction<br>|
| cohort of ovarian cancer organoids<br>organoids derived from ovarian cancer | Other: construction of organoids from gynecological tumor<br>* organoids construction<br>|
| cohort of vulva cancer organoids<br>organoids derived from vulva cancer | Other: construction of organoids from gynecological tumor<br>* organoids construction<br>|
| cohort of vaginal cancer organoids<br>organoids derived from vaginal cancer | Other: construction of organoids from gynecological tumor<br>* organoids construction<br>|
| cohort of gestational trophoblastic tumor organoids<br>organoids derived from gestational trophoblastic tumor | Other: construction of organoids from gynecological tumor<br>* organoids construction<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Construction of BioBank | BioBank including organoids banks, tissue banks, PDX banks, immune cell banks, and primary banks from other tissue sources | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Drug sensitivity detection based on organoids banks | Exploring drug sensitivity detection in gynecological tumors based on organoid libraries | one year | 
| Exploring the molecular mechanism based on organoids banks | Exploring the molecular mechanism of gynecological tumor pathogenesis based on organoid banks | one year |