The Lasting Change Study

Study Overview
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Brief Summary
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The study approach is to leverage the most cutting-edge techniques of multi-omics biology, wearable physiology, and digital real-time psychology profiling and using machine learning models to understand the mechanisms underlying the strategies and techniques that enable participants the power to initiate and maintain sustainable behavior change. Over the years, millions of people worldwide have attended immersive personal development seminars aiming to improve participants' health behaviors and wellness. Nevertheless, there's a scarcity of large-scale studies to assess their effects on behavior change and investigate their mechanism of action. A recent publication by the Science of Behavior Change Program (SOBC), launched by the National Institute of Health (NIH), recognized that: science has not yet delivered a unified understanding of basic mechanisms of behavior change across a broad range of health-related behaviors, limiting progress in the development and translation of effective and efficacious behavioral intervention. As such, understanding the mechanisms underlying sustainable behavior change is key. The Date With Destiny (DWD) seminar is among the largest worldwide, and tens of thousands of people have already attended and testified to its transformative effect. The main objective of the study is to uncover the underlying mechanism of behavior change through longitudinal data collection of psychometrics Ecological Momentary Assessments, physiology (wearables), and biology (multi-omics) in study participants. The study specific objectives include: (1) To evaluate the impact of DWD on sustainable behavior change; (2) To investigate the mechanism of behavior change by collecting longitudinal real-time measurements of psychometrics (e.g., Ecological Momentary Assessments [EMA]), physiological (e.g., heart rate, blood oxygen level, breathing rate, and EDA), and biological (multi-omics analyses) features in study participants; (3) To assess the effect of the DWD on professional fulfillment, resilience, and mental wellness.

Detailed Description
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The work is done partly as the doctorate thesis of Ziv Lautman (Stanford University, Department of Genetics).

Official Title
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The Stanford Lasting Change Study

Conditions
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Psychological Wellness, Resilience, Psychological, Personal and Professional Fulfilment, Wearable Devices, Multiomics

Intervention / Treatment
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* Behavioral: Date With Destiny (DWD) Seminar


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 18-years-old and older English speaker Live in the US Participate in the DWD seminar (December 2-7, 2022) Exclusion Criteria: Any physical or mental condition that limits the ability to participate in the study (e.g., answering e-questionnaires and wearing an electronic device) Serious active comorbidity or terminal illness Pregnancy Participation in any other clinical study focusing on psychological or behavioral intervention.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| DWD participants<br>Individuals that voluntarily chose to participate in DWD seminar. | Behavioral: Date With Destiny (DWD) Seminar<br>* 6 days of immersive seminar<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mental performance biomarker index | An algorithm will be used to create an index score using known biomarkers (psychosocial, physiological, and biological) related to participants' personalized mental performance. Higher index scores will indicate a better mental performance index. | one-year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in participant mental wellness score | Mental wellness scores rated by participants | baseline through year one | 
| Participant resilence score | Resilience scores rated by participants | baseline through year one | 
| Participant professional fullfilment score | Professional fulfillment scores rated by participants | baseline through year one | 
| Participant self efficacy score | Self-efficacy scores rated by participants | baseline through year one | 
| Participant quality of life score | Quality of life scores rated by participants | baseline through year one | 
| Participant stress score | Stress scores rated by participants | baseline through year one | 
| Participant mindset score | Mindset growth scores rated by participants | baseline through year one | 
| Participant goals achievement score | Goal achievement scores rated by participants | baseline through year one | 
| Participant human needs score | Human needs fulfillment scores rated by participants | baseline through year one |