The Effect Of Antenatal Corticosteroids On Early And Late Perinatal Outcomes

Study Overview
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Brief Summary
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In this study, the investigators aims to evaluate whether antenatal corticosteroid administration to women likely to give birth in the late preterm period will reduce early and late neonatal complications and contribute to the literature in this sense.

Detailed Description
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This study is a single-center prospective case-control study investigating the effect of antenatal corticosteroids administered in the late preterm period on early and late perinatal outcomes. 459 patients who gave birth between 34-37 weeks between June 1,2021 to October 1,2022 in the Obstetrics and Gynecology Clinic of the University of Health Sciences were included. Patient were divided into two groups antenatal corticosteroid administration (n:231) and non-administration (n:228). Postpartum early and late perinatal outcomes were compared between these two groups.

Official Title
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The Effect Of Antenatal Corticosteroids On Early And Late Perinatal Outcomes In Late Preterm Pregnant Women

Conditions
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Preterm Pregnancy, Antenatal Corticosteroid, Perinatal Problems

Intervention / Treatment
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* Other: participants receiving Corticosteroid


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All pregnant women who had normal vaginal delivery, cesarean section or operative delivery between 34-37 weeks Singleton pregnancies resulting in a live birth Exclusion Criteria: Twin pregnancies All births before 34 weeks or after 37 weeks Pregnant women with intrauterine ex fetus Fetuses with major congenital and chromosomal abnormalities Pregnant women who administrated antenatal corticosteroids for any reason before 34 weeks

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Antenatal corticosteroid non-administration<br>Pregnant women who did not use antenatal corticosteroid before 34 weeks | |
| Active Comparator: Antenatal corticosteroid administration<br>Pregnant women using antenatal corticosteroids for any reason before 34 weeks | Other: participants receiving Corticosteroid<br>* Pregnant women using antenatal corticosteroids for any reason before 34 weeks<br>* Other names: dekort;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The results of antenatal corticosteroid effects | intramuscular 3 mg betamethasone (dekort 8mg/2 ml) corticosteroid injection in perinatal period | 16 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Other consequences of antenatal corticosteroid effects in late term pregnant women | Other consequences of antenatal corticosteroid administered in late preterm pregnant women in the neonatal period are the need for neonatal intensive care due to reasons other than respiratory distress, respiratory complications such as pneumonia, other complications such as sepsis, perinatal death, chronic lung disease (even after 28 days of birth, oxygen need) long-term outcomes in postnatal infants ( third month, sixth month, twelfth month, emotional and emotional consequences in the family, and maternal side effects. | 16 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Antenatal corticosteroids, Late preterm pregnancy, Late perinatal outcomes