Effects of Prostate Cancer on Brain Function

Study Overview
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Brief Summary
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To explore whether the patients with prostate cancer have functional changes in specific brain areas and changes in psychological and mental characteristics compared with the patients without prostate cancer.

Detailed Description
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This study was intended to observe the functional changes of brain fMRI in patients with and without prostate cancer enrolled in the cohort of patients who planned to undergo prostate biopsy, in an attempt to discover specific brain region changes in patients with prostate cancer, and lay a foundation for further clarifying the relationship and mechanism between brain region function changes and prostate cancer.

Official Title
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The Effects of Prostate Cancer on Brain Function: a Prospective Cohort Study

Conditions
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Prostate Cancer

Intervention / Treatment
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* Diagnostic Test: functional magnetic resonance imaging examination、Zung Self Rating Anxiety Scale and Beck Depression Inventory-II


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Between the ages of 18 and 80 Patients with prostate biopsy; No history of other malignant tumors; Exclude other malignant tumors; Fully understand the clinical trial protocol and sign informed consent; Exclusion Criteria: magnetic resonance contraindications; symptomatic acute or chronic inflammation of the prostate; Patients with brain trauma or brain disease; Patients who have died of other malignancies in the past or are currently suffering from other malignancies; Patients judged by the investigator to be unfit to participate in the clinical trial;

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Prostate cancer group<br>Prostate cancer was confirmed by biopsy, and fMRI examination 、Zung Self Rating Anxiety Scale and Beck Depression Inventory-II were performed in these patients within 1 week before biopsy . | Diagnostic Test: functional magnetic resonance imaging examination、Zung Self Rating Anxiety Scale and Beck Depression Inventory-II<br>* fMRI examination 、Zung Self Rating Anxiety Scale and Beck Depression Inventory-II were performed in these patients within 1 week before biopsy .<br>|
| Non-Prostate cancer group<br>Non-Prostate cancer was confirmed by biopsy, and fMRI examination 、 Zung Self Rating Anxiety Scale and Beck Depression Inventory-II were performed in these patients within 1 week before biopsy . | Diagnostic Test: functional magnetic resonance imaging examination、Zung Self Rating Anxiety Scale and Beck Depression Inventory-II<br>* fMRI examination 、Zung Self Rating Anxiety Scale and Beck Depression Inventory-II were performed in these patients within 1 week before biopsy .<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The evaluation of Magnetic Resonance(MR) | To compare the differences in rs-fMRI measures (Amplitude of low frequency fluctuations , Regional Homogeneity and Functional Connectivity ) between prostate cancer group and Non-prostate cancer group. | Within 1 week before biopsy | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment of anxiety status | Zung Self Rating Anxiety Scale was used to assess anxiety status.By comparing the final score, less than or equal to 10 is considered healthy, and more than 10 is considered abnormal. | Within 1 week before biopsy | 
| Assessment of depressive status | Beck Depression Inventory-II was used to assess depressive status.By comparing the final scores, a score of 50 or less is considered healthy and a score of 50 or more is considered abnormal. | Within 1 week before biopsy | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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prostate cancer, functional magnetic resonance imaging(fMRI), Brain function