Music Therapy on Neutrophyl Lymphocytes Ratio, Interleukin 6 and Interleukin 10 Levels of Burnout Syndrome

Study Overview
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Brief Summary
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Burnout Syndrome (BOS) can be defined as a state of stress both physically and psychically due to the burden and stressor of high work. The prevalence of BOS in health workers varies between 25-75% globally. Studies have shown that the presence of Burnout syndrome will meaningfully reduce the quality of services related to patient safety and cause immune system disorders that act as the body's defense against viral, bacterial, protozoal and fungal infections. Many strategies have been researched to help prevent and reduce the occurrence of Burnout syndrome, one of which is music therapy. The purpose of this study was to determine the effect of music therapy on the immune response in health workers with Burnout Syndrome. This study is a randomized clinical trial with a pre and post test control group design for health workers at Dr Kariadi General Hospital and Dr. Cipto Mangunkusumo General Hospital. Subjects will be provided with information prior to the study and asked to sign an informed consent sheet if they agree to be involved in the study. Subjects will be divided into control groups and treatment groups with matching age, gender and type of work. In the treatment group, music therapy will be given as much as 3 times a week for 4 weeks. Data were taken on both groups before and after the intervention. This study used the Maslach Burnout Inventory Human Service Survey (MBI-HSS) and blood laboratory examination to determine the value of the Neutrophyl Lymphocyte Ratio, Interleukin 6 and Interleukin 10 levels.

Official Title
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The Effect of Music Therapy on Neutrophyl Lymphocytes Ratio, Interleukin 6 and Interleukin 10 Levels of Healthcare Workers With Burnout Syndrome

Conditions
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Burnout Syndrome, Neutrophil-Lymphocyte Ratio, Interleukin-6, Interleukin-10

Intervention / Treatment
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* Other: music therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 years - 60 years old Health workers in the wards and polyclinic of Dr. Cipto Mangunkusumo Hospital or Dr. Kariadi Hospital, including doctors in charge of patients, nurses, residents, and other supporting health workers Included in the Burnout syndrome criteria from the Maslach Burnout Inventory-Human Service Survey questionnaire Exclusion Criteria: Refusing to follow the study Have a history of heart disease, kidney disease, diabetes, cancer, tuberkulosis, autoimmune, immunodeficiency Taking drugs that affect the central nervous system or immunosuppressants Have hearing disorder Have a psychiatric disorder Being pregnant Healthcare workers who don't like music

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control<br>Given education only | |
| Experimental: Intervention<br>Given education and music therapy | Other: music therapy<br>* Music therapy that have been made by Music Therapist after Focus Group discussion, given three times a week for 4 weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Burnout syndrome | Maslach Burnout Inventory Human Service Survey (MBI-HSS) score | change from baseline score at 4 weeks | 
| Neutrophil Lymphocyte Ratio | Measured with Fluorescence Flow Cytometry | Change from baseline Neutrophil Lymphocyte Ratio at 4 weeks | 
| Interleukin 6 | Measured with Fluorescence Immunoassay | Change from baseline Interleukin-6 level at 4 weeks | 
| Interleukin 10 | Measured with ELISA | Change from baseline Interleukin-10 level at 4 weeks |