Application of Sticky Bone and Bio-Oss Collagen in Alveolar Ridge Preservation

Study Overview
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Brief Summary
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In this experiment, after non-traumatic tooth extraction, the blank group underwent natural healing, and the control group underwent alveolar ridge preservation using Bio-Oss Collagen and the experimental group using Sticky Bone, to verify the application of Bio-Oss Collagen and Sticky Bone in alveolar ridge preservation

Detailed Description
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Within 6 months after tooth extraction, the remaining alveolar ridge undergoes varying degrees of absorption, resulting in a decrease in horizontal width and vertical height of the alveolar ridge. The three-dimensional size change of the alveolar socket may affect the implantation of later implants and cause aesthetic and functional problems. Alveolar ridge preservation can maintain the volume of the alveolar socket, prevent soft tissue from growing into undesirable positions, slow down the absorption of the alveolar ridge to some extent, promote new bone formation, and maintain the shape of the extraction socket. This is crucial for later implant treatment for missing teeth. In this experiment, after non-traumatic tooth extraction, the blank group underwent natural healing, and the control group underwent alveolar ridge preservation using Bio-Oss Collagen and the experimental group using Sticky Bone, respectively, to verify the application of Bio-Oss Collagen and Sticky Bone in alveolar ridge preservation

Official Title
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Application of Sticky Bone and Bio-Oss Collagen in Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial

Conditions
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Alveolar Bone Resorption

Intervention / Treatment
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* Procedure: alveolar ridge preservation with bio-oss collagen
* Procedure: alveolar ridge preservation with sticky bone


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The presence of one adjacent tooth at the extraction site Adequate oral hygiene (plaque index <20%;bleeding on probing <25% ) Need for tooth extraction due to endodontic，periapical or periodontal disease. Presence of ≥ 2 mm of keratinized tissue the extraction sockets have no more than 50% of buccal alveolar bone loss(Integrity of alveolar bone walls) Exclusion Criteria: Pregnancy or lactation Smoking more than 10 cigarettes per day with no evidence of acute infection such as severe swelling, suppuration at the extraction site Uncontrolled periodontal disease Existence of bone metabolic disease history of malignancy, radiotherapy, or chemotherapy in the past 5 years Administration of bisphosphonates long-term use of NSAIDs Alcohol or drug abuse Infectious disease, such as hepatitis or human immunodeficiency virus (HIV) and/or acquired immunodeficiency syndrome (AIDS) Uncontrolled severe diabetes.( hemoglobin A1c >6.7%)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: The control group underwent natural healing, and the experimental group underwent alveolar ridge preservation using Bio-Oss Collagen and Sticky Bone, respectively.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: blank group<br>After non-traumatic tooth extraction, the control group will undergo natural healing. | |
| Active Comparator: control group<br>After non-traumatic tooth extraction, the control group will use alveolar ridge preservation with bio-oss collagen | Procedure: alveolar ridge preservation with bio-oss collagen<br>* Alveolar ridge preservation with bio-oss collagen is a surgical method that reduces or limits the physiological resorption of alveolar bone after tooth extraction by implanting bio-oss collagen in the socket and covering the biological barrier membrane.<br>|
| Experimental: experimental group<br>After non-traumatic tooth extraction, the experimental group will use Sticky Bone for alveolar ridge preservation | Procedure: alveolar ridge preservation with sticky bone<br>* Alveolar ridge preservation with sticky bone is a surgical method that reduces or limits the physiological resorption of alveolar bone after tooth extraction by implanting sticky bone in the socket and covering the biological barrier membrane.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in horizontal ridge widths | Changes in horizontal ridge widths at 1, 3, and 5 mm below the ridge crest | baseline (before the surgery) and six months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in the vertical heights of the ridge | Changes in the vertical heights of the ridge at the buccal and lingual crest areas | baseline (before the surgery) and six months | 
| Thicknesses of the keratinized gingiva | Thicknesses of the keratinized gingiva at 2 and 4mm below the highest point of the gingiva | baseline (before the surgery) and six months | 
| width of the keratinized gingiva | width of the keratinized gingiva | baseline (before the surgery) and six months | 
| percentages of newly formed bone | percentages of newly formed bone and residual bone substitute material in histologic sections | six months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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alveolar ridge preservation, Bio-OSS Collagen, sticky bone