Infertility and Pregnancy Outcomes of Fertility Spared Gynecological Oncology Patients

Study Overview
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Brief Summary
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FSS which aims to preserve a woman's fertility while still effectively treating the cancer, has become an increasingly popular option for young women diagnosed with these types of cancers. It is important to assess how FSS affects a woman's reproductive health, sexual function, psychological well-being, and overall quality of life. This research aims to provide valuable insights into the long-term effects of FSS on a woman's life, and can help healthcare providers make informed decisions about the best treatment options for their patients.

Detailed Description
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This is a prospective cohort study that aims to evaluate the infertility and pregnancy outcomes, as well as the quality of life of women who underwent fertility-sparing surgery for gynecological malignancies. The study included a comprehensive evaluation of the participants' medical history, surgical procedures, oncological treatment, and fertility preservation methods. Participants recruited from a tertiary care hospital, and women diagnosed with gynecological malignancies (e.g. cervical, ovarian, endometrial cancer) who underwent fertility-sparing surgery between 2010 and 2022. Women who have undergone total hysterectomy, bilateral salpingo-oophorectomy, or adjuvant oncological treatment were excluded from the study. Participants were contacted by phone and asked to complete questionnaires to assess their quality of life using the WHOQoL-BREF and FertiQoL scales.

Official Title
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The Evaluation of Infertility and Pregnancy Outcomes, as Well as the Assessment of Quality of Life Using WHOQoL and FertiQoL, in Cases of Gynecological Malignancies That Have Undergone Fertility-sparing Surgery(FSS)

Conditions
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Fertility Disorders, Gynecologic Cancer

Intervention / Treatment
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* Procedure: Fertility sparing surgery


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosis of gynecologic cancer, and being fertile in the meantime Applying directly to gynecologic oncology department Demand of preserving the fertility Exclusion Criteria: Having hysterectomy prior to the diagnosis Having bilateral ooferectomy prior to the diagnosis Being in menopause Not accepting to fill the survey High stage disease which is not able to have FSS

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 49 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: The study included a comprehensive evaluation of the participants' medical history, surgical procedures, oncological treatment, and fertility preservation methods.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Fertility spared gynecologic cancer diagnosed women<br>Participants recruited from a tertiary care hospital, and women diagnosed with gynecological malignancies (e.g. cervical, ovarian, endometrial cancer) who underwent fertility-sparing surgery between 2010 and 2022. | Procedure: Fertility sparing surgery<br>* Sparing the uterus and/or ovaries of the patients suffering from gynecologic malignancies to keep the patients' fertility<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of pregnancy of patients received FSS | Incidence and rate of patients getting pregnant after FSS | In 12 years after FSS | 
| Rate of pregnancy after FSS of patients seeking fertility by applying to IVF clinics | Rate of patients referring to IVF clinic after FSS | In 12 years after FSS | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Satisfaction assesed by WHO-QoL Bref and decision-regret scale after FSS | % of patients' satisfaction via Quality of life after the surgery, and decision-regret analysis regarding to fertility sparing by the validated questionnaires | 12 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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fertility sparing, gynecologic malignancy, quality of life, infertility