The Role of Pentraxin 3 and Cathepsin B Levels in Preeclamptic Pregnancy

Study Overview
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Brief Summary
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In this study, the investigator aim was to compare Cathepsin B and Pentraxin 3 levels measured from maternal serum of pregnant women diagnosed with preeclampsia in the second trimester, the effects of these levels on maternal/ fetal outcomes and the composite results of Cathepsin B and Pentraxin 3 levels alone or together and contribute to the literature in this area.

Detailed Description
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This prospective case-control study was conducted between 1 January 2022 and 31 December 2022 at Bursa Yuksek Ihtisas Training and Research Hospital. The study was conducted with pregnant women between ages of 18-45 who were diagnosed with preeclampsia in the second trimester. This study was conducted with total 156 pregnant women. participants were grouped according to the presence of preeclampsia; Group1: Patients diagnosed with preeclampsia between 20-28 weeks (study group) (n:78) , Group 2: Healthy pregnant women between 20-28 weeks without a diagnosis of preeclampsia ( control group) (n:78) . As soon as preeclampsia is diagnosed and before any treatment was started, maternal serum samples were collected in the Cathepsin B and Pentraxin 3 kit in amounts suitable for the study. The samples obtained were kept in biochemistry laboratory at -80 degrees until the study was conducted. After all samples were collected, Cathepsin B and Pentraxin 3 values were measured by ELISA method.

Official Title
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The Role of Pentraxin 3 and Cathepsin B Levels in the Second Trimester in Predicting of Maternal and Fetal Results in Preeclamptic Pregnancy

Conditions
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Pre-Eclampsia, Cathepsin B Level, Pentraxin 3 Level

Intervention / Treatment
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* Other: Cathepsin B and pentraxin 3 levels in preeclampsia with pregnant women


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Singleton pregnancy Pregnant women diagnosed with preeclampsia between 20-28 weeks of gestation Healthy pregnant women between 20-28 weeks of gestation who want to be involved in the study. Exclusion Criteria: Multiple pregnancies Pregnant women who gave birth below 24 weeks of gestation Pregnant women diagnosed with other hypertensive diseases of pregnancy other than preeclampsia ( gestational hypertension, chronic hypertension, superimposed hypertension) Pregnant women with chromosomal or congenital anomalies in the fetus Women with a known infective or autoimmune disease before pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pregnant women with preeclampsia between 20-28 weeks (study group)<br>Maternal serum cathepsin B and pentraxin 3 levels in 20-28 weeks pregnant women with preeclampsia | Other: Cathepsin B and pentraxin 3 levels in preeclampsia with pregnant women<br>* The effect of cathepsin b and pentraxin 3 levels on maternal/fetal outcomes in pregnant women diagnosed with preeclampsia<br>|
| Healthy pregnant women between 20-28 weeks ( control group)<br>Maternal serum cathepsin B and pentraxin 3 levels in 20-28 weeks healthy pregnant women ( control group) | Other: Cathepsin B and pentraxin 3 levels in preeclampsia with pregnant women<br>* The effect of cathepsin b and pentraxin 3 levels on maternal/fetal outcomes in pregnant women diagnosed with preeclampsia<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of the effects and composite results of cathepsin b and pentraxin 3 levels in pregnant women diagnosed with preeclampsia | serum cathepsin b (nmoL pNA/mL) and serum pentraxin 3 (ng/ml) levels composite results on pregnant women diagnosed with preeclampsia | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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second trimester, preeclampsia, pentraxin 3, Cathepsin B