Coronavirus Infection (COVID-19) and Radical Surgery in Patients With Early-stage Lung Cancer

Study Overview
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Brief Summary
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The goal of this observational study is to learn about the effects of coronavirus infection in patients with early-stage lung cancer. The main question it aims to answer is whether the interval of surgery and COVID-19 infection will affect the surgery and prognosis of the patients.

Official Title
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Effects of Coronavirus Infection (COVID-19) on the Timing and Prognosis of Radical Surgery in Patients With Early-stage Lung Cancer

Conditions
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Surgery, Corona Virus Infection

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinically diagnosed stage I and stage II lung cancer, who are about to receive wedge resection, segmental resection, sleeve resection, lobectomy, or pneumonectomy under general anaesthesia. Volunteer to participate in the study with good compliance. Able to complete the observation and follow-up and have signed the informed consent. ASA score: I-III; Cardiopulmonary functions meet the requirements of radical operation for lung cancer with normal liver and kidney functions. Exclusion Criteria: Neurologic, mental illness or mental disorder which is hard to control, poor compliance, unable to cooperate or describe the treatment response; Clinically diagnosed stage III and stage IV lung cancer or patients who received neoadjuvant treatment before surgery; Patients developed symptoms alike coronavirus infection but are not confirmed by viral RNA detection by quantitative RT-PCR or antigen testing kits. Serious heart, lung, liver and kidney dysfunction and unable to tolerate the operation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| stage I/II lung cancer patients<br>Patients with stage I/II lung cancer will receive radical surgery. | Other: No intervention<br>* Observational study, no intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative morbidity | rate of perioperative complications, mainly include: pneumonia, respiratory failure, pulmonary embolism, arrhythmia, sepsis, cerebrovascular accident, myocardial injury, acute kidney injury. | postoperative in-hospital stay up to 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative hospital stay | length of postoperative hospitalization | postoperative in-hospital stay up to 30 days | 
| operation time | duration of operation | At operation day | 
| R0 rate | R0 resection rate | postoperative in-hospital stay up to 30 days | 
| blood loss | blood loss in the operation | At operation day | 
| 30-day mortality | 30-day mortality after surgery | postoperative in-hospital stay up to 30 days | 
| quality of life | postoperative quality of life | postoperative in-hospital stay up to 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lung cancer, Surgery, Corona Virus Infection