linjc16/ctgov huggingface dataset:
Effect of Mediterranean Diet in Inflammatory Bowel Disease

Study Overview
=================
Brief Summary
-----------------
The effects of diet on inflammatory bowel disease is an under-studied area of research. The investigators are interested in further investigating the role that diet contributes to inflammatory bowel disease severity. The investigators will collect blood and stool samples from patients with inflammatory bowel disease (IBD) before and after diet changes. The stool samples will be analyzed using metabolomics and microbiome analysis to determine changes after the new diet has been implemented. The investigators will then compare changes in the patient's overall disease state by measuring markers of inflammation including C-reactive protein (CRP) and fecal calprotectin to determine how this diet affects the disease state.

Official Title
-----------------
Implementing Metabolomics Informed Diet on Inflammatory Bowel Disease Patients

Conditions
-----------------
Inflammatory Bowel Disease

Intervention / Treatment
-----------------
* Dietary Supplement: Mediterranean Diet


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years old or older Meet classification criteria for inflammatory bowel disease including those with mild to moderate Crohn's Disease as defined by a Crohn's disease activity index between 150-450, with fecal calprotectin>250, within 1 month of enrollment. Exclusion Criteria: Unable to provide informed consent History of or current drug abuse Pregnancy Start or change in dose of standard-of-care treatment within 12 weeks of the screening Known allergy to any component of the proposed diet Subjects with significant other medical or psychiatric comorbidities and /or medication use which in physician's clinical judgment might difficult the interpretation of the results Patients that are not on a stable dose of medications, for instance, steroids, in between samples collection Patients on antibiotics Patients with C difficile infection within 4 weeks of enrollment

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Mediterranean Diet<br>Mediterranean Diet for 42 Days | Dietary Supplement: Mediterranean Diet<br>* Mediterranean Diet for 42 Days<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| short Crohn's Disease Activity Index (sCDAI) | Mild to moderate Crohn's Disease is defined by a short Crohn's Disease activity index (sCDAI) between 150-450, while those in remission from Crohn's Disease have an sCDAI score below 150. An sCDAI score exceeding 450 is used as a marker of severe Crohn's Disease. | 42 Days |
Intradural Disc Herniation: a Case Report and Review of Complications

Study Overview
=================
Brief Summary
-----------------
This observational study collects clinical data as well as pathological reports from a patient with an intradural disc herniation, reports on the course of the patient's recovery through surgical treatment, summarizes the complications of this type of disease, and provides new ideas for improving the chances of preoperative diagnosis.

Detailed Description
-----------------
We collect the patient's personal history, family history, reason for visit, visit flow, clinical data, pathology reports, and surgical images and videos.

Official Title
-----------------
Intradural Disc Herniation: a Case Report and Review of Complications

Conditions
-----------------
Disc Herniation

Intervention / Treatment
-----------------
* Procedure: total laminectomy decompression


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: IDH patients Exclusion Criteria: no

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: total laminectomy decompression|Surgical decompression|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| physiology | Grayish-white tissue identified as degenerated disc tissue was removed from the patient's lumbar spine partially within the dura mater | 07/2023 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Intradural disc herniation, Complications, Degenerative spinal disease, Decompression
AI-driven Quality Assessment of YouTube Videos Providing Information on Incontinence After Cancer Surgery.

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to analyse the quality of information that patients and relatives of different types of cancer receive through social networks on the subject of incontinence after cancer surgery.

Detailed Description
-----------------
The primary goal of this study is to meticulously analyze and evaluate the overall quality of information that patients and their relatives obtain through social networks. The specific focus of the investigation lies in exploring the subject of incontinence after cancer surgery, encompassing a diverse range of cancer types. By closely examining the information disseminated across various social platforms, the researchers aim to shed light on the accuracy, reliability, and comprehensiveness of the information available. Ultimately, this study seeks to enhance our understanding of the information landscape surrounding post-cancer surgery incontinence, empowering patients and their relatives to make well-informed decisions regarding their healthcare.

Official Title
-----------------
Assessment of Health Knowledge and Related Educational Intervention

Conditions
-----------------
Cancer, Incontinence, Patient Education, Social Networks, Surgery

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Anyone providing information about incontinence after cancer surgery. English language Exclusion Criteria: Non-english language Duplicated Related with advertisements Nonrelated to incontinence
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Samples group<br>Samples collected regarding the online information about incontinence after cancer surgery. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analisys of the information in social networks about incontinence after cancer surgery | Analisys of the information in social networks about incontinence after cancer surgery | 2023-2024 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Cancer, Incontinence, Patient Education, Social Networks, Surgery, Youtube
French Translation and Validation of the PEYronie's Disease QUESTionnaire

Study Overview
=================
Brief Summary
-----------------
This study is a prospective cohort dedicated to peyronie's disease. The aim is to validate the french translation of the peyronie's disease questionnaire. The primary endpoint is the response rate to the questionnaire.

Official Title
-----------------
French Translation and Validation of the PEYronie's Disease QUESTionnaire

Conditions
-----------------
Peyronie Disease

Intervention / Treatment
-----------------
* Other: FRAnçaise du PEYronie's Disease QUESTionnaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patient with Peyronie's Disease clinically diagnosed during a consultation, with palpation of at least one plaque Exclusion Criteria: Patient refusing to participate Patient with difficulties in understanding the French language. Protected persons referred to in articles L.1121-6 to L.1121-8 of the public health code

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: FRAnçaise du PEYronie's Disease QUESTionnaire|Complete an online FRAnçaise du PEYronie's Disease QUESTionnaire|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of responses | Response rate to the online questionnaire. | Day 0 |
Knowledge, Attitude and Practice in Utilization of Vital Pulp Therapy in Permanent Teeth by Pediatric Dentists in Egypt

Study Overview
=================
Brief Summary
-----------------
Conducting this questionnaire will help in collecting information about the extent of knowledge, attitude, and practice of utilization of vital pulp therapy in permanent teeth among pediatric dentists in Egypt. This will aid in identifying the knowledge gap, interest, attitude, and practice challenges regarding vital pulp therapy.

Official Title
-----------------
Knowledge, Attitude and Practice in Utilization of Vital Pulp Therapy in Permanent Teeth by Pediatric Dentists in Egypt: A Cross-sectional Study

Conditions
-----------------
Vital Pulp Therapy

Intervention / Treatment
-----------------
* Behavioral: Knowledge assessment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pediatric dentists who work in Egypt. Dentists who finished any postgraduate study in pediatric dentistry. The workplace should be anywhere in Egypt Exclusion Criteria: Dentists who did not practice for the last 5 years. Responses with incomplete information

Ages Eligible for Study
-----------------
Minimum Age: 24 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Knowledge assessment|Knowledge, Attitude and Practice Survey|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Knowledge of Vital Pulp Therapy in Permanent Teeth | Measured by a KAP questionnaire, and the measuring unit is multiple choice questions. | From the 1st of December- 2023, to the 29th of February- 2024. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Attitude and Practice towards Vital Pulp Therapy in Permanent Teeth | Measured by a KAP questionnaire, and the measuring unit is multiple choice questions. | From the 1st of December- 2023, to the 29th of February- 2024. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Vital Pulp Therapy, Permanent Teeth, Pediatric Dentists
Polypropylene vs Polyglactin in Suturing of the Lung

Study Overview
=================
Brief Summary
-----------------
Comparative study comparing polypropylene and Polyglactin in suturing of the lung

Detailed Description
-----------------
Lung tear or, pulmonary laceration is an injury in lung parenchyma, said injury can be caused by several reasons: Blunt chest trauma Penetrating trauma such as stab wounds or firearm wounds Iatrogenic, such as faulty intercostal tube insertion

Official Title
-----------------
Polypropylene vs Polyglactin in Suturing of the Lung

Conditions
-----------------
Lung Injury, Bleb Lung, Lung Cancer

Intervention / Treatment
-----------------
* Procedure: lung suturing with polyglactin
* Procedure: ung suturing with polypropylene


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients admitted to Assiut University Hospital And will undergo surgery for lung tear repair. Patients admitted to Assiut University Hospital And will undergo surgery for bullectomy or lobectomy. Exclusion Criteria: Patients with lung injury repaired with a stapler

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Polyglactin group<br>lung suturing with polyglactin | Procedure: lung suturing with polyglactin<br>* lung suturing with polyglactin<br>|
| Polypropylene Arm<br>lung suturing with Polypropylene | Procedure: ung suturing with polypropylene<br>* ung suturing with polypropylene<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| duration in days of intercostal tube air leak with each group | Polypropylene vs Polyglactin | 2 weeks |
Systems Oncology Approach to Optimize Ovarian Cancer Treatment

Study Overview
=================
Brief Summary
-----------------
The overall aim is to identify effective therapeutic strategies to ovarian cancer (OC) using serial tumor, ascites and blood samples, and carry out state-of-the-art sequencing approaches, functional assays and associated bioinformatics to understand mechanisms behind chemoresistance in OC and identify new treatment options for OC patients. In this observational trial, we will systematically collect, analyze and interpret functional, molecular and clinical data from real-world ovarian cancer patients.

Official Title
-----------------
Systems Oncology Approach to Optimize Ovarian Cancer Treatment

Conditions
-----------------
Ovarian Cancer

Intervention / Treatment
-----------------
* Genetic: Biomolecular profiling


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients diagnosed with ovarian cancer Available tumor tissue/blood samples Exclusion Criteria: Inability to consent to the study
Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Genetic: Biomolecular profiling|Molecular and functional analysis of biospecimens, including tumor-normal Whole-exome sequencing, bulk and single-cell RNAsequencing, spatial proteomics, functional testing.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recruitment and collection of real-world clinical data from ovarian cancer patients | Prospective recruitment and collection of clinical data from 500 ovarian cancer patients. Fraction of patients from which the collection of clinical data including patient age, tumor stage, histological diagnoses have been collected. | 5 years | 
| Successful collection and translational analysis of biospecimens | Fraction of the recruited patients, from which tumor, ascites, and/or peripheral blood samples that have been successfully collected and subjected to molecular profiling. | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Discovery of candidate prognostic and predictive biomarkers | Number of clinical and/or molecular features which of statistically significantly correlate to patient treatment outcomes (response to chemotherapy by RECIST1.1, Progression Free survival, Overall Survival). | 5 years |
Medical Imaging in Bladder Tumors by MRI

Study Overview
=================
Brief Summary
-----------------
This study prospectively included 178 patients with bladder neoplastic lesions who planned to undergo surgery (with or without preoperative neoadjuvant chemotherapy). Inclusion criteria: Patients with pathologically confirmed bladder cancer after radical or partial cystectomy or TURBT (< 2 weeks between surgical resection and imaging). Exclusion criteria: 1) Prior history of chemotherapy and/or radiotherapy; 2) No surgical resection; 3) The interval between surgical resection and imaging examination is > 2 weeks; 4) Obvious artifacts; 5)MRI scan contraindications. All subjects underwent pelvic MRI. Data was collected using a Siemens VIDA 3TMR scanner (Siemens Healthcare, Erlangen, Germany). All subjects underwent standardized scanning protocols. The obtained images are post-processed and the experimental results are analyzed statistically.

Official Title
-----------------
Clinical Study on the Diagnostic and Predictive Value of MRI Multifunctional Imaging in Bladder Tumors

Conditions
-----------------
Bladder Tumor, Magnetic Resonance Imaging

Intervention / Treatment
-----------------
* Other: MRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosis of bladder neoplasm Must undergo radical or partial cystectomy or TURBT surgery within 2 weeks between surgical resection and imaging Exclusion Criteria: A history of pelvic radiotherapy or chemotherapy; Lack of pathological findings or no surgery; The interval between surgical resection and imaging examination > 2 weeks; Poor image quality due to poor coordination or motion artifacts; MRI scan contraindications
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: MRI|Functional sequence imaging (MDME, IVIM) sequences were added to the routine MRI scan of patients with bladder tumor|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| quantitative parameters by MRI | quantitative parameters by functional MRI | From the time the participants completed the MRI scan to the post-processing of the resulting images,assessed up to 2 months |
Variation of Echocardiographic Parameters After Red Blood Cell Transfusion in Emergency Department Anemic Patients

Study Overview
=================
Brief Summary
-----------------
The goal of this interventional study is to asses echocardiographic variations in emergency department's elderly patients receiving red blood cell transfusion. The main questions it aims to answer are : is there a modification of echocardiographic parameters after red blood cell transfusion ? which parameter is the most impacted by red blood cell transfusion ? Participants will have a transthoracic echocardiography before, just after and 15 minutes after red blood cell transfusion.

Official Title
-----------------
Variation of Echocardiographic Parameters After Red Blood Cell Transfusion in Emergency Department Anemic Patients

Conditions
-----------------
Anemia, Age Problem, Ultrasonography

Intervention / Treatment
-----------------
* Diagnostic Test: transthoracic echocardiography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patient needing red blood cell transfusion consent social protection Exclusion Criteria: fluid filing over 500 mL of crystalloids transfusion in the last hour

Ages Eligible for Study
-----------------
Minimum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: transfused patients<br>patients receiving red blood cell transfusion | Diagnostic Test: transthoracic echocardiography<br>* E wave, A wave, e' and vdi measurement<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| E/A ratio modification | E/A ratio permits to estimate left ventricle pressure | Base line, just after and 15 minutes after red blood cell transfusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| E/e' ratio modification | E/e' assesses left ventricle diastolic function | Base line, just after and 15 minutes after red blood cell transfusion | 
| E wave deceleration time | E wave deceleration time is a reflect of left atrium pressures | Base line, just after and 15 minutes after red blood cell transfusion | 
| Velocity-time Integral (VTI) modification | Aortic velocity-time integral is the reflect of cardiac output | Base line, just after and 15 minutes after red blood cell transfusion | 
| Lung score modification | Lung score permits to asses if extravascular water is present in lungs | Base line, just after and 15 minutes after red blood cell transfusion | 
| New York Heart Association scale (NYHA) modification | NYHA is a validated scale to asses patient dyspnea | baseline and 24 hour after red blood cells transfusion |
Taking a Look at Patient Experiences In Rectal Cancer Clinical Trials

Study Overview
=================
Brief Summary
-----------------
The primary objective of this research study is to explore the barriers encountered by specific demographic groups of rectal cancer patients during the engagement in clinical trials, which historically lack diverse representation. By carefully analyzing data from various demographic perspectives, this study aims to uncover patterns that impact the experiences of future rectal cancer patients. Active involvement in this crucial research is of utmost importance, as it can offer unique insights to enhance the participation and completion rates of rectal cancer patients in clinical study.

Official Title
-----------------
Investigating Medical Research Trends in Rectal Cancer Clinical Study: Analyzing Factors Impacting Patient Involvement

Conditions
-----------------
Rectal Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Confirmed diagnosis of rectal cancer Aged ≥ 18 years old and ability to provide written informed consent obtained prior to participation in the study and any related procedures being performed No prior treatment for rectal cancer Exclusion Criteria: Pregnant or lactating woman Inability to provide written informed consent Enrolled in another research study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of rectal cancer patients who decide to participate in a clinical study |  | 3 months | 
| Rate of patients who remain in a rectal cancer clinical study to completion |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Rectal Cancer