Observational Study on Monitoring NSAID-Induced Gastropathy in Patients Using Magnetically-Controlled Capsule Gastroscopy

Study Overview
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Brief Summary
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The objective of this study is to observe gastric mucosal injuries in NSAID and non-NSAID users with magnetically-controlled capsule gastroscopy, and explore the effects of NSAIDs on gastric mucosal damage.

Detailed Description
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Non-steroidal anti-inflammatory drugs are widely used in all kinds of people in China. A major limitation to their use is the adverse effects they cause on the gastrointestinal tract, including the formation of stomach lesions, ulcers due to stress reactions, and damage to the healing of gastric ulcers. The purpose of this prospective, single-center study was to monitor the gastric mucosal injury in patients with and without NSAIDs using magnetron capsule gastroscopy, and to explore the effect of NSaids on gastric mucosal injury. For people taking NSAIDs, it is necessary to regularly detect gastric mucosal damage, and timely intervention treatment is required if relevant lesions are found, and the medication plan is adjusted. Magnetron capsule gastroscope has the advantages of comfort, safety, no anesthesia, no risk of cross infection, etc. It is highly accepted by the population, and is a beneficial supplement to traditional gastroscopy, so that some people with absolute or relative contraindications of traditional gastroscopy can get timely endoscopy, and can be diagnosed and treated early.

Official Title
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Observational Study on Monitoring NSAID-Induced Gastropathy in Patients Using Magnetically-Controlled Capsule Gastroscopy

Conditions
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NSAID-Associated Gastropathy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Planned magnetically-controlled capsule gastroscopy NSAID use >3 months or no NSAID use Informed consent Exclusion Criteria: No surgical conditions or refuses abdominal surgery (Once the capsule is stuck it cannot be removed surgically); Cardiac pacemakers (except MRI-compatible ones); Electronic implants or metal foreign bodies; Pregnant women; Known or suspected GI obstruction, stenosis, fistula; Dysphagia.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| NSAIDs users<br>90 patients taking NSAIDs for over 3 months | |
| non-NSAIDs users<br>90 non-NSAIDs users undergoing physical examination | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gastric diseases detected | Gastric diseases detected | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gastric mucosal injury by Lanza score | Gastric mucosal injury by Lanza score | 1 day | 
| Gastric transit time | Gastric transit time | 1 day | 
| Gastric cleanliness | Gastric cleanliness | 1 day | 
| Effects of NSAID duration on gastric injury | Effects of NSAID duration on gastric injury | 1 day | 
| Effects of NSAID dosage on gastric injury | Effects of NSAID dosage on gastric injury | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Magnetically-controlled Capsule Endoscopy