Gestational Diabetes Mother-infant Cohort

Study Overview
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Brief Summary
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The bi-directional dynamic cohort study is to learn about the effects of prenatal exposure to high blood glucose levels and postnatal nurturing environment factors on delayed language development in children. The study investigated the results of blood glucose screening during pregnancy for the children's mothers, and followed up on the blood glucose management effectiveness of pregnant women with abnormal blood glucose levels before delivery. Participants will be also surveyed the S-S method for language development assessment, gsell Scale, and 0-6 year-old family nurturing environment evaluation scale to evaluate the language development and family nurturing environment.

Detailed Description
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Glucose management during pregnancy and the postnatal nurturing environment are keys to early detection and early intervention of language delay, which is important to reduce abnormal language development in children. In this study, mothers diagnosed with gestational diabetes mellitus in the department of hospital and offspring were used as participants. The investigators take a follow-up visit to participants' offspring using the S-S method of language development assessment, gsell Infant and Toddler Development Scale, and 0-6 years old family parenting environment evaluation scale. The bi-directional dynamic cohort study is to learn about the effects of prenatal exposure to high blood glucose levels and postnatal nurturing environment factors on delayed language development in children.

Official Title
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A Cohort Study on the Impact of Gestational Blood Glucose Management and Postnatal Nurturing Environment on Delayed Language Development in Children

Conditions
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Gestational Diabetes Mellitus in Pregnancy, Cognitive Impairment, Cohort Study

Intervention / Treatment
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* Behavioral: Acquired nurturing environment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children 1.5-2.5 years old with no serious underlying diseases and no hearing impairment. Exclusion Criteria: diagnosed hearing impairment, organic dysarthria, oral disease; (ii) cerebral palsy; neurological and hereditary metabolic diseases; (iv) deaf father/mother.

Ages Eligible for Study
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Minimum Age: 1 Year
Maximum Age: 3 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Gestational diabetes offspring cohort<br>The Gestational diabetes(GDM) offspring cohort is to learn about language development assessment in 2-year-old children and causal association with their mother who diagnosed GDM | Behavioral: Acquired nurturing environment<br>* Superimposed effects of intrauterine high-sugar environment exposure and postnatal nurturing environment exposure<br>|
| Healthy maternal offspring cohort<br>Healthy maternal offspring cohort is to learn about language development assessment in 2-year-old children and causal association with their health mother | Behavioral: Acquired nurturing environment<br>* Superimposed effects of intrauterine high-sugar environment exposure and postnatal nurturing environment exposure<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| delayed language development in children | Number of participants diagnosed with GDM, Number of offspring of participants who participated in the survey of family nurturing environments, and Composition ratio of offspring with GDM who presented with language delays. | 2023.1-2025.11 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Child cognitive impairment, Intrauterine high-glucose environment, Acquired nurture environment