Peroperative Fluid Management in Major Gynecological Cancer Surgeries

Study Overview
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Brief Summary
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The aim of this study is to evaluate the effect of perioperative fluid management on postoperative kidney damage in gynecological cancer surgeries. The main question[s] it aims to answer are: Does fluid management applied with different hemodynamic monitoring methods affect the risk of postoperative AKI? In our clinic, three different fluid management strategies are applied depending on the anesthetist experience. Acute kidney injury will be evaluated according to the postoperative AKIN classification of conventional fluid therapy and targeted fluid therapy with noninvasive or minimally invasive monitoring.

Detailed Description
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Our study was designed as a retrospective study. The files of patients over the age of 18 who underwent open abdominal surgery due to ASAII and III gynecological malignancy will be examined retrospectively. Patients who cannot be monitored peroperatively and who undergo HIPEC will be excluded from the study. Patients will be divided into 3 groups according to the fluid management strategy and the hemodynamic monitoring used: Group 1: patients receiving conventional fluid therapy; Group 2: patients receiving targeted fluid therapy with noninvasive monitoring; Group 3: patients receiving targeted fluid therapy with minimally invasive monitoring.

Official Title
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The Effect of Peroperative Fluid Management Strategy on Postoperative Renal Functions in Major Gyneco-oncological Surgeries

Conditions
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Fluid Overload, Fluid Loss, Perioperative/Postoperative Complications, Acute Kidney Injury

Intervention / Treatment
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* Diagnostic Test: Akut kidnet injury(AKI)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: >18 years ASA II-III Those with normal renal function Exclusion Criteria: Patients in renal insufficiency Patients with perioperative renal, ureter & bladder invasion Patients in whom perioperative urine monitoring cannot be performed Patients undergoing HIPEC Patients with missing data

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Conventional fluid therapy<br>Patients who received conventional fluid therapy | Diagnostic Test: Akut kidnet injury(AKI)<br>* postoperative 24 hours<br>* Other names: AKI developing in the patient group receiving minimal invaziv goal directed therapy;|
| Experimental: Non invaziv goal directed therapy<br>Patients who received non invaziv goal directed therapy | Diagnostic Test: Akut kidnet injury(AKI)<br>* postoperative 24 hours<br>* Other names: AKI developing in the patient group receiving minimal invaziv goal directed therapy;|
| Experimental: Minimal invaziv goal directed therapy<br>Patients who received minimal invaziv goal directed therapy | Diagnostic Test: Akut kidnet injury(AKI)<br>* postoperative 24 hours<br>* Other names: AKI developing in the patient group receiving minimal invaziv goal directed therapy;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of acute kidney injury | Our primary aim was to evaluate the postoperative day(POD1 ) creatinine values(mg/dl) | Change from preoperative to postoperative day 1(POD1)creatinine values(mg/dl) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peroperative fluid amounts | The seconder aim to investigate the amount of fluid used peroperatively | during the operation period | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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akut kidney injury, goal directed fluid therapy, peroperative fluid management, conventional fluid therapy