Effects of e-Cigarettes on Perceptions and Behavior - Substudy 2

Study Overview
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Brief Summary
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This project will assess the ways in which e-cigarette product diversity impacts the user experience to inform potential regulations by identifying product characteristics that may: (1) put young adults at risk for tobacco product use; and (2) facilitate adult smokers switching to e-cigarettes. There are three primary objectives to the study: (1) Determine which dimensions of e-cigarette product diversity differentially affect product appeal in the overall population of tobacco product users as well as affect product appeal across young adult e-cigarette users and middle-age/older adult smokers; (2) Determine which dimensions of e-cigarette product diversity differentially affect product appeal in the overall population of tobacco product users as well as affect abuse liability in young adult e-cigarette users and the ability to resist smoking in adult smokers; (3) Determine the affect of product characteristics on e-cigarette nicotine delivery profile. For this substudy, adult smokers (N=200) will attend two laboratory session in which they will self-administer e-cigarette products varied according to within-subject e-cigarette factors (e.g., flavor, nicotine formulation) and smoke their own cigarettes.

Official Title
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Effects of e-Cigarettes on Perceptions and Behavior - Substudy 2

Conditions
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Electronic Cigarette Use, E-Cig Use, Cigarette Smoking, Cigarette Use, Electronic

Intervention / Treatment
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* Other: E-cigarette e-liquid self-administration


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Regular use of cigarettes containing nicotine. Exclusion Criteria: Pregnant or planning to become pregnant.

Ages Eligible for Study
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Minimum Age: 21 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: E-cigarette e-liquid 1<br>Participants will self-administer an e-cigarette e-liquid. | Other: E-cigarette e-liquid self-administration<br>* Participant will self-administer an experimenter-provided e-cigarette.<br>|
| Experimental: E-cigarette e-liquid 2<br>Participants will self-administer an e-cigarette e-liquid. | Other: E-cigarette e-liquid self-administration<br>* Participant will self-administer an experimenter-provided e-cigarette.<br>|
| Experimental: E-cigarette e-liquid 3<br>Participants will self-administer an e-cigarette e-liquid. | Other: E-cigarette e-liquid self-administration<br>* Participant will self-administer an experimenter-provided e-cigarette.<br>|
| Experimental: E-cigarette e-liquid 4<br>Participants will self-administer an e-cigarette e-liquid. | Other: E-cigarette e-liquid self-administration<br>* Participant will self-administer an experimenter-provided e-cigarette.<br>|
| No Intervention: No e-liquid<br>Participants do not receive an e-cigarette e-liquid to self-administer. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subjective Appeal Rating Questionnaire | This self-report measure of product appeal will be completed following e-cigarette self-administration. Scores can range from 0 to 100 for the appeal rating, with lower scores representing lower levels of appeal and higher scores representing higher levels of appeal. | 1 hour | 
| Sensory Attributes Rating Questionnaire | This self-report measure of product sensory attributes will be completed following e-cigarette self-administration. Scores can range from 0 to 100 for the sensory attribute rating, with lower scores representing lower levels of liking the sensory attribute and higher scores representing greater liking of the sensory attribute. | 1 hour | 
| Smoking Delay Task | Minutes delayed before purchasing time to smoke own cigarettes. Scores can range from 0mins to 50mins for the smoking delay task, with lower scores representing fewer minutes delayed from smoking and higher scores representing longer minutes delayed from smoking. | 1 hour |