Sleep and Memory Consolidation in Adults With Attention Deficit Hyperactivity.

Study Overview
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Brief Summary
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Attention Deficit Disorder With Hyperactivity is associated with deficits in cognition and sleep. In healthy adults, memory consolidation processes are related to sleep spindle activity in the sleep electroencephalogram. This association is poorly characterized in adults with attention deficit hyperactivity. In this study, the purpose is to characterize sleep microarchitecture disorders through the analysis of different stage of sleep EEG activity during a polysomnographic examination in adult with mixed Attention Deficit Disorder With Hyperactivity presentation compared to healthy.

Official Title
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Sleep and Memory Consolidation in Adults With Attention Deficit Hyperactivity.

Conditions
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Attention Deficit Disorder With Hyperactivity

Intervention / Treatment
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* Other: Neurological examinations


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria for all participants: Age from 18 to 45 years old Affiliated to the French health care system Inclusion Criteria for attention deficit hyperactivity disorder patients: meeting Diagnostic and Statistical Manual (DSM)-5 criteria for mixed attention deficit hyperactivity disorder presentation without drug treatment for attention deficit hyperactivity disorder. Exclusion Criteria for all participant: People not able to give consent, neurological disease (other than neurodevelopmental disorders; or any other serious disease (cancer, addiction, systemic disease)), untreated sleep apnea, major depression (Beck inventory > 15), untreated restless leg syndrome; pregnancy in progress or wish to become pregnant during the study or breastfeeding woman, drug treatment including benzodiazepine, neuroleptic or antidepressant before inclusion. Exclusion Criteria for healthy volunteers: Subjective cognitive and/or sleep complaint.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Attention Deficit Disorder With Hyperactivity<br>Patients with Attention Deficit Disorder With Hyperactivity. Same examinations than control group | Other: Neurological examinations<br>* Neurological, neuropsychological, polysomnography examinations and multiple sleep latency test. The protocol is divided into three visits.<br>|
| Active Comparator: Control<br>Healthy volunteers Same examinations than Attention Deficit Disorder With Hyperactivity group | Other: Neurological examinations<br>* Neurological, neuropsychological, polysomnography examinations and multiple sleep latency test. The protocol is divided into three visits.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in signal power (db or μV 2) in the sigma frequency bands in N2 sleep | difference between 2 groups | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sleep, Memory