linjc16/ctgov huggingface dataset:
Definition of Mutational Profile of Papillary Thyroid Tumors by Mass-ARRAY

Study Overview
=================
Brief Summary
-----------------
Somatic mutations in the MAP (mitogen-activated protein) kinase pathway have been found in about 80% of papillary thyroid tumors (PTCs). The evaluation of the PTC mutational profile is crucial for the definition of the prognosis and for predicting the effects of targeted and personalized therapies. Molecular characterization by mass spectrometry (Mass ARRAY) allows the search for multiple mutations in a single experiment, in a sensitive, fast and economic way. A Mass ARRAY platform (PTC-MA) was developed, capable of identifying the presence of the most common somatic point mutations and rearrangements in PTC (Pesenti et al., Endocrine 2017). The aim of the study is to characterize the mutational profile of a large series of papillary thyroid carcinomas (PTC). Tumor samples will be analyzed using our PTC-MA platform. The molecular profile of PTCs will be correlated with the clinical and prognostic characteristics of the patients.

Official Title
-----------------
Caratterizzazione Del Profilo Mutazionale Nel Tumore Papillare Della Tiroide Tramite Tecnologia Mass-ARRAY

Conditions
-----------------
Papillary Thyroid Cancer

Intervention / Treatment
-----------------
* Genetic: Genotyping


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with papillary thyroid cancer patients whose tumor tissue can be recovered for genetic analysis Exclusion Criteria: patients who did not give consent patients lost to follow-up tumor samples not suitable for genetic analysis
Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with papillary thyroid cancer<br> | Genetic: Genotyping<br>* Characterization of genetic profile of tumor tissues<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mutational profile of PTCs | The mutational profile of about 600 PTCs will be characterized and correlate with the clinical characteristics and patient outcomes | years 1-8 |
Glottis Visualization in Different Lifting Methods

Study Overview
=================
Brief Summary
-----------------
Among the various types of video laryngoscopes, the McGrath MAC video laryngoscopy (VL) has become popular because it is lightweight and can be quickly and hygienically prepared by changing the blade. The aim of this study was to compare the efficacy of two different methods (direct and indirect) for epiglottis removal during visualization of the glottis using the McGrath MAC VL.

Official Title
-----------------
Comparison of Epiglottis Lifting Methods Using a McGrath Video Laryngoscope: Direct vs. Indirect

Conditions
-----------------
Intubation, Glottis Visualization

Intervention / Treatment
-----------------
* Device: using McGrath Video Laryngoscope


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ASA I-II general anesthesia in elective surgeries 18-65 years old body mass index (25-30) no risk of difficult intubation Exclusion Criteria: Allergic to study drugs pregnant women emergency cases those with a history of difficult intubation those without consent those at risk of aspiration

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group Direct<br>glottis visualization in direct lifting | Device: using McGrath Video Laryngoscope<br>* glottis visualization in indirect and direct lifting methods by using McGrath Video Laryngoscope<br>|
| Group Indirect<br>glottis visualization in indirect lifting | Device: using McGrath Video Laryngoscope<br>* glottis visualization in indirect and direct lifting methods by using McGrath Video Laryngoscope<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| POGO scores | percentage of glottic opening | 1 day (through intubation ) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cormack-Lehane classification | assessment of laryngeal view during laryngoscopy | 1 day (through intubation ) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Endotrakeal intubation, Epiglottis, Glottis, McGrath MAC video laryngoscope
Hypoplastic Left Heart Syndrome: Subendocardial Viability After Norwood Palliation

Study Overview
=================
Brief Summary
-----------------
This project has several objectives ranging from clinical data analysis to computational simulations as listed below: Retrospective review of all patients with HLHS treated surgically and followed medically at the IRCCS Policlinico San Donato aiming to assess the SEVR after each step of Norwood palliation to analyze its influences on: Mortality; Occurrence of adverse events; Outcome of the three-staged palliation; Creation of a prospective registry that will enroll all patients surgically treated for HLHS at the IRCCS Policlinico San Donato.

Official Title
-----------------
Hypoplastic Left Heart Syndrome: Subendocardial Viability After Norwood Palliation

Conditions
-----------------
Hypoplastic Left Heart Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pediatric patients (age ≤18 years) with the diagnosis of hypoplastic left heart syndrome who underwent the Norwood palliation at the IRCCS Policlinico San Donato. Exclusion Criteria: Patients with any type of atrioventricular discordance. Pediatric patients (age ≤18 years) with the diagnosis of hypoplastic left heart syndrome who underwent the Norwood palliation at the IRCCS Policlinico San Donato before March 2019.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality during the hospital stay and after the discharge | death, cardiovascular arrest | 5 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of adverse events registered during the follow-up. | Patients will be followed prospectively with their normal routine cardiological follow-up for 5 years | 5 year |
COVID-19 Infection and Idiopathic Membranous Nephropathy

Study Overview
=================
Brief Summary
-----------------
Infection is one of common risk factors for relapsing of idiopathic membranous nephropathy (IMN). However, it is still unclear wheather COVID-19 infection can induce the relapsing of IMN. Herein, in this prospective, multi-center, cohort study, the investigator enrolled the IMN patients with COVID-19 infection. All subjects will be followed for three months with four visits at 1, 2 and 3 months. Then the investigator will compare the rate of replase of IMN in the two groups to evaluate the association of COVID-19 infection and replapse of IMN.

Official Title
-----------------
The Association of COVID-19 Infection and Relapse of Idiopathic Membranous Nephropathy

Conditions
-----------------
Idiopathic Membranous Nephropathy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: the status of nephrotic syndrome is complete remmision or partial remmision; estimated glomerular filtration rate (eGFR according to the CKD-EPI formula) ≥60 mL/min per 1.73 m2; patients with a moderate risk of IMN. Exclusion Criteria: secondary causes of MN; the labarotary data two months before enrolement is absent.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COVID-19 infection group<br>the patients with IMN and COVID-19 infection | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| primary outcome | relaspe of nephrotic syndrome: proteinuria<0.3g/d, serum albumin>30g/l, serum creatitine below 111 μmol/l | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| secondary outcome | relaspe of nephrotic syndrome: proteinuria<3.5g/d (decreased over 50% of baseline), serum albumin>30g/l, steady serum creatitine (fluctuated less than 20% of baseline), meet the above criteria over 2 times | 0.5, 1, and 2 months |
Predictive Value of PS Application in Premature Infants With RDS

Study Overview
=================
Brief Summary
-----------------
A multicenter prospective study was conducted to compare the predictive value of 6-zone, 10-zone, and 12-zone LUS scores for PS application in early and late preterm infants.

Official Title
-----------------
Predictive Value of PS Application in Premature Infants With RDS by Different Pulmonary Ultrasound Scores: a Prospective Multicenter Study

Conditions
-----------------
Respiratory Distress Syndrome

Intervention / Treatment
-----------------
* Diagnostic Test: Lung ultrasound


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Hospital admission within 2 hours after birth; The diagnosis was RDS; Parents agree to attend Exclusion Criteria: chromosomal abnormalities or complex congenital malformations; congenital pulmonary disease; severe sepsis, disseminated intravascular coagulation, septic shock and other critical conditions; LUS and blood gas analysis have been examined before the application of alveolar surfactant.

Ages Eligible for Study
-----------------
Minimum Age: 1 Day
Maximum Age: 1 Month

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PS application<br> | Diagnostic Test: Lung ultrasound<br>* Lung ultrasound score was calculated by the results of lung ultrasound examination<br>|
| non-PS application<br> | Diagnostic Test: Lung ultrasound<br>* Lung ultrasound score was calculated by the results of lung ultrasound examination<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Whether the patient uses ps (pulmonary surfactant) | The standards used by PS are based on the European consensus | 2023.2-2023.12 |
Bariatric Surgery Observation Study Part 2

Study Overview
=================
Brief Summary
-----------------
The goal of this observational study is to explore the longterm effects of two bariatric surgical procedures by inviting patients from three public hospitals who had Roux-en-Y gastric bypass or Sleeve gastrectomy to a follow-up after10-15 years The main question[s] it aims to answer are: The duration of the surgical method on weight reduction and remission of comorbidities Theprevalence of complications and new morbidities after the surgical procedures Participants will be asked be asked to fill inn questionnaires, have a clinical examinition have an interview with nurse and doctor have blood samples taken undergo other investigations

Detailed Description
-----------------
The BAROBS project is a collaberation between three public hospitals in Norway exploring the concequeces ten years or more after undergoing gastric bypass or sleeve gastrectomy for severe obesity. 1400 patients who underwent bariatric surgery at the three hospitals will be invited to a follow up including antrophometric, meassurment of bodily composition by bioimpedance and DXA, blood samples, questionnaires on sosioeconomic topics, symptoms and quality of life, continous glucose monitoring, dental examination, and other clinical evaluation.

Official Title
-----------------
Bariatric Surgery Observation Study Part 2 An Observational Study of Patients Who Underwent Bartiatric Surgery in Public Hospitals in Central Norway 2010-2015.

Conditions
-----------------
Bariatric Surgery Candidate

Intervention / Treatment
-----------------
* Procedure: Bariatric surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Bariatric surgery at Namsos Hospital, St. Olavs hospital or Ålesund Hospital from 01.01.2010 to 31.12.2015 Exclusion Criteria: Not able to consent for participation Includable participants not longer living in Norway

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Bariatric surgery|JDF11 JDF41 JDF97|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Long-term weight loss | Total weight loss after bariatric surgery | 10-15 years after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Remission of comorbidities after bariatric surgery | Remission of Type 2 Diabetes Mellitus, Hypertension and Sleep Apnoe | 10-15 years after surgery | 
| Quality of life after bariatric surgery | Health related quality of life, SF -36 | 10-15 years after surgery |
FibroLamellar Carcinoma: an International Registry Study

Study Overview
=================
Brief Summary
-----------------
Fibrolamellar Hepatocellular Carcinoma (FLC) is a rare (0.05 per 100,000) subtype of primary liver cancer which predominantly affects younger patients, median age of diagnosis 22-23 years. In patients with advanced stage disease the prognosis is poor, and even with aggressive surgery the 5 year survival is less than 50%. Due to the very low incidence of FLC clinical trials are limited, and as these patients are excluded from most clinical trials there is a lack of consensus on the optimal systemic therapy to employ in this population group. There are a number of chemotherapy compounds that have been investigated although these are single-institutional case series and/or registry-based studies. The majority of published registry studies are based in the United States hence it is important to describe the patterns of treatment in Europe which has different regulatory approvals for access to therapeutics. Our aim is to run a European multisite registry study detailing the clinical course of >100 patients with FLC that have received systemic therapy.

Official Title
-----------------
FibroLamellar Carcinoma: an International Registry Study

Conditions
-----------------
Fibrolamellar Cancer of the Liver

Intervention / Treatment
-----------------
* Procedure: Registry of Therapy of patient's diagnosed with FibroLamellar


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Histologic confirmed diagnosis of FLC Written informed consent will be required for the prospective cohort Adults of >18 years of age Exclusion Criteria: Any non- histologic confirmed diagnosis of FLC Participants with insufficient clinical/ follow up data

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Registry of Therapy of patient's diagnosed with FibroLamellar|Registry of Therapy of patient's diagnosed with FibroLamellar|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To describe the natural history and clinical outcomes of patients with Fibrolamellar carcinoma of the liver | The following data will be outcomes of interest in this study: treatments received including compliance and tolerability, survival (overall and progress free survival), clinicopathological outcomes. Survival outcomes, response rates | 2 years |
Medical Follow-up of Medical Secretaries of General Practitioners

Study Overview
=================
Brief Summary
-----------------
General practitioners are very often confronted with requests for care from their relatives (family, friends, etc.). In the United States, the recommendations advise general practitioners against taking care of their loved ones on several grounds: lack of professional objectivity, lack of information due to modesty, risk of loss of patient autonomy. Some countries even prohibit general practitioners from prescribing to a loved one except in an emergency. In France, there is no current recommendation on the care of relatives. Half of French general practitioners have a physical secretary and are therefore potentially confronted with requests for care from their medical secretary.

Detailed Description
-----------------
The aim of the study is to describe the medical follow-up of medical secretaries of general practitioners

Official Title
-----------------
Medical Follow-up of Medical Secretaries of General Practitioners

Conditions
-----------------
Medical Follow-up of Medical Secretaries

Intervention / Treatment
-----------------
* Other: Data collection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: medical secretaries of general practitioners work in face-to-face in the medical practice agreed to participate in the study Exclusion Criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| medical secretaries of general practitioners group<br>Men and women working as a secretary for a general practitioner, face-to-face in the medical practice. | Other: Data collection<br>* Data collection<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| type of attending physician | type of attending physician will be either the general practitioner employing the medical secretary or an another physician (an another general practitioner or a specialist) | Day 1 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
medical secretaries, general practitioners, medical follow-up
Comparison of Extremely Obese Patients Undergoing Gastric Sleeve Surgery

Study Overview
=================
Brief Summary
-----------------
By the comparison of the preoperative and postoperative data of approximately 160 patients undergoing gastric sleeve surgery, we try to draw conclusions about the effectiveness of gastric sleeve surgery, expected complication rate.

Detailed Description
-----------------
We plan to compare the preoperative and postoperative data of approximately 160 patients undergoing gastric sleeve surgery (android-gynoid, male-female, comparison of patients with different degree of obesity, age comparison, etc.) Many preoperative and postoperative data are known about the patients (weight, height, BMI, preoperative comorbidities, heart ultrasound values, respiratory function values, laboratory parameters, smoking habits, rate of weight loss in half a year and one year, etc.). By statistical analysis of these data, we try to draw conclusions about the effectiveness of gastric sleeve surgery, expected complication rate, etc.,

Official Title
-----------------
Comparison of Different Tipe Extremely Obese Patients Undergoing Gastric Sleeve Surgery in Terms of Perioperative Risk (Cardiopulmonary Parameters and Other Perioperative Risk Factors) and Effectiveness of the Intervention

Conditions
-----------------
Obesity, Morbid, Hypertension, Diabetes Mellitus, Type 2

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Obesity (BMI higher than 30 kg/m2) Exclusion Criteria: Lack of patient consent to the study, Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessing the results of gastric sleeve surgery, by weight loss | weight loss (kg) | up to one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessing the half and one-year results of gastric sleeve surgery, by change in comorbidities | change in comorbidities (the clinical improvement of the given comorbidity, for example in the case of hypertension, the patient's antihypertensive medications can be reduced or completely omitted, ect.) | half year, one year | 
| Assessing the half and one-year results of gastric sleeve surgery, comparing different groups (male-female, android-gynoid tipe of obesity, ect.) | weight loss (kg) | half year, one year | 
| Assessing the half and one-year results of gastric sleeve surgery, weight loss. (We try to find a confluence between the perioperative parameters and the expected outcome) | weight loss (kg) | half year, one year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
gastric sleeve operation