Prospective Hyperthermia Database in Cancer Patients (HT Register)

Study Overview
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Brief Summary
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This monocentric study registry records all cancer patients at the Charité which are treated with hyperthermia to examine the therapeutic use of hyperthermia in cancer patients in the general application and to obtain an accurate risk-benefit balance After confinement in this database are the patients prospectively in order to complications, disease status and survival status tracked. Furthermore there is the possibility in the course of this study to an optional take part in translational accompanying research with the aim of prognostic factors for response to hyperthermia treatment.

Detailed Description
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A total of 1000 patients with various diseases with the indication for hyperthermia in addition to standard oncological therapy (radiation therapy, chemotherapy, radiochemotherapy) will be included in this registry protocol.

Official Title
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Prospektive Hyperthermie-Datenbank Bei Krebspatienten (HTRegister)

Conditions
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Hyperthermia, Cancer

Intervention / Treatment
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* Other: Hyperthermie Register


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Contrazeption with female patients at the capable of bearing children age Written agreement is present (DvH, ICH-GCP) Patients, who participate at the same time in a interventional study, can nevertheless in this register study participate if this none Exclusion criterion for the interventional study represents. With children must the treatment with one of the GPOH agreed Pattern take place Exclusion Criteria: Exclusion criteria for the hyperthermia (such as hip prosthesis in the therapeutic area, metal implants/marker, patients with cardiac pacemakers) mental disease, what the proper study participation does not allow.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hyperthermie Register<br>Hyperthermia simultaneous with Radiotherapy alone, Hyperthermia simultaneous with Chemotherapy alone, Hyperthermia simultaneous with Radiochemotherapy alone | Other: Hyperthermie Register<br>* die Höhe der Temperatur im Zielgebiet (42,5 bis 43 °C), die Dauer der Anwendung und die simultane Therapie mit Chemo- und/oder Strahlentherapie<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effectivity | To determine the effectiveness of hyperthermia treatment, patients are tracked in terms of overall survival , progression-free survival and disease-free survival | Through the study completion, up to 10 years | 
| Toxicity | Toxicity assessment based on Common Toxicity Criteria Scoring | Through the study completion, up to 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Hyperthermia E02.565, HTRegister