Pain AND Opioids After Surgery

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to document the perioperative opioid use and its safety in the UK and countries in Europe and to describe its association with surgical complications, persistent pain and quality of life. In an international, prospective, observational cohort study, data about the perioperative pain management will be collected in all eligible hospitalised adult patients who undergo surgery in a designated study week in as many hospitals as possible in Europe. Baseline data will be collected, and participants followed up at one week, and at three and twelve months post-operatively. The primary outcome will be opioid use at three months after surgery. Secondary outcomes will include opioid use during the preoperative month (preoperative use), during surgery and up to one week after surgery (or discharge, whichever is earlier), and up to the end of the postoperative year. Additional secondary outcomes are the incidence of preoperative pain, persistent pain with/without the presence of neuropathic components, quality of life and surgical complications. The potential association between opioid use and pain outcomes will be investigated. This study could help to develop strategies to improve quality of care, through pain management, for patients undergoing surgery.

Official Title
-----------------
Pain and Opioids After Surgery (PANDOS) Study

Conditions
-----------------
Opioid Use, Pain, Chronic, Pain, Postoperative, Quality of Life

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: hospitalised adult patients (18 years and older) undergoing any inpatient surgery (elective or emergency) during the designated study week where an anaesthetist is involved (general anaesthetic, sedation, local anaesthetic). Able to understand and has capacity to give written informed consent Exclusion Criteria: American Society of Anaesthesiologists (ASA) grade V or VI Refusal to participate. Lack of comprehension of validated questionnaires or inability to complete the follow-up for any reason. Lack of capacity to give written informed consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient reported Opioid use post surgery | Patient reported use of opioids post surgery | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Opioid use | Patient reported use of opioids pre-op and opioids used during surgery and prescribed post surgery | From recruitment to 1 year post surgery | 
| Patient reported incidence of pain | Patient reported incidence of pain pre-op and post surgery using BPI-SF | From recruitment to 1 year post surgery | 
| Patient reported incidence of pain | Patient reported incidence of pain pre-op and post surgery using DN2 | From recruitment to 1 year post surgery | 
| Surgical complications | Recording of surgical complications during surgery | During surgery | 
| Participant reported quality of life | EQ5D-5L | From recruitment to 1 year post surgery | 
| Participant reported quality of life | BPI-SF | From recruitment to 1 year post surgery |