Impact of ICU on the Quality of Life in Cancer Patients

Study Overview
=================
Brief Summary
-----------------
This is an observational, prospective, monocentric, case-control study. Investigators aim to compare the quality of life and oncological treatment strategy in cancer patients admitted or not in ICU.

Detailed Description
-----------------
Inclusion of cancer patients (cases) at discharge of surgical, cardiovascular and thoracic and medical ICU of the Grenoble Alpes University Hospital. Cases will be matched with cancer patients identified in oncologist's consultation. Inclusion of controls from oncologist consultations (2 controls for 1 case) For cases and controls, medical data will be collected at inclusion, 3 and 6 months.

Official Title
-----------------
Impact of ICU on the Quality of Life and Oncological Care of Patients With Solid Tumors

Conditions
-----------------
Solid Tumor, Adult

Intervention / Treatment
-----------------
* Other: Questionnaires


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: > 18 ans Non-opposition of the patient or relatives Lung, head and neck or colorectal cancer Non scheduled ICU admission At least 24 hours of ICU stay Alive at ICU discharge Able to answer by phone to quality of life questionary Exclusion Criteria: Unable to answer by phone to quality of life questionary Patient participating in another clinical study that could interfere with the results of the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cases<br>> 18 years old Non-opposition of the patient or relatives Lung, head and neck or colorectal cancer Non scheduled ICU admission At least 24 hours of ICU stay Alive at ICU discharge Able to answer by phone to quality of life questionary | Other: Questionnaires<br>* Quality of life questionary: 36-Item Short Form Survey Instrument (36-SF) at 3 and 6 months from inclusion By phone<br>|
| Controls<br>Cancer patients not admitted in ICU, matched with the cases according to the type of primary cancer the presence or absence of oncogenic addiction the setting of anticancer treatment (curative/palliative) the line of anticancer treatment (none/L1/L2-L3/>L3). | Other: Questionnaires<br>* Quality of life questionary: 36-Item Short Form Survey Instrument (36-SF) at 3 and 6 months from inclusion By phone<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| quality of life questionary 36-item short form survey instrument (36-SF) | score of 0 (poor quality of life) to 100 (very good quality of life) | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| intensity of antitumoral treatment compared to standard treatment | standard treatment vs adaptated treatment vs palliative care standard treatment was defined by the treatment recommended in the ESMO guidelines for each cancer (lung, colorectal, and head and neck cancer) | 3 months | 
| quality of life questionary 36-item short form survey instrument (36-SF) | score of 0 (poor quality of life) to 100 (very good quality of life) | 6 months | 
| intensity of antitumoral treatment compared to standard treatment | standard treatment vs adaptated treatment vs palliative care standard treatment was defined by the treatment recommended in the ESMO guidelines for each cancer (lung, colorectal, and head and neck cancer) | 6 months | 
| ECOG - Performance status | From 0 (fully active) to 5 (dead) | 3 months and 6 months | 
| Activities of Daily Living | From 0 (dependent ) to 6 (autonomous) | 6 months | 
| Hospital Anxiety and Depression Scale | Anxiety scale from 0 (no anxiety) to 21 (anxiety) Depression Scale from 0 (no depression) to 21 (depression) | 3 months and 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Quality of life, Oncological care, intensive care unit, solid tumor