Pharmacogenetics Study on the Effects of Anesthetic Drugs on Circulatory Function

Study Overview
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Brief Summary
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This study intends to study the effects of anesthetics on Circulatory Function Genomics and find the anesthetic effects in pharmacodynamics, pharmacokinetics, drug receptor or target DNA level differences, further guiding individual treatment in clinic, promoting the development of precision the medicine.The anesthesia medication during perioperative period is more and more accurate,reasonable and safe, so as to improve the satisfaction of the patients and their families in the perioperative period, to ensure the safety of patients.

Detailed Description
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This study is a non traumatic and non intervention study, and will use a large sample of clinical research, the number of subjects to be enrolled in the study group are 200 cases. The basic information of the study was included in the study before the operation. During the operation, the investigators need a collection of participants's arterial blood and monitor the hemodynamic index and anesthesia depth by bispectral index(BIS) . Further more，the investigators will follow up the participants' condition after operation.Dividing the patients into different groups according to their clinical features.The relationship between vital signs and the depth of anesthesia was analyzed and compared between different groups.Blood samples collected during the operation were detected by gene test. Comparing the results of genetic testing and clinical data analysis, then the investigators will find the differences in the expression of the gene polymorphisms of anesthetic drugs in the circulating function.

Official Title
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The Effects of Anesthetic Drugs on Hemodynamic Changes in Cardiac Surgury and the Assotiation Between Gene Polymorphysim and Different Heart Diseases :a Pharmacogenetics Study

Conditions
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Drug Reaction, Anesthetic, Hemodynamic Rebound, Gene

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Undergoing general anesthesia Undergoing Cardiovascular surgery Exclusion Criteria: ASA granding more than five Severe organ dysfunction

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Genotyping results of anesthetic drugs | Genotype information of SNP related to anesthetic drug metabolism, such as AA, AG or GG | one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| vital signs | The percentage of change in mean arterial pressure and heart rate | one year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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personalized medicine, genetic polymorphism, pharmacogenetics, hemodynamic change