Comparison of NSAID Patch Given in Monotherapy and NSAID Patch in Combination With Transcutaneous Electric Nerve Stimulation, Heating Pad, or Topical Capsaicin in the Treatment of Patients With Myofascial Pain Syndrome of the Upper Trapezius: A Pilot Study

Study Overview
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Brief Summary
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Myofascial pain syndrome (MPS) is a common clinical problem of musculoskeletal pain and various treatment modalities have been introduced. If self-applicable physical modalities and medications that are used for treatment of MPS patients are combined, they may open up new possibilities for effective and practical self-care. The aim of this study is to compared the therapeutic effect of non-steroidal anti-inflammatory drug (NSAID) patch given in monotherapy and NSAID patch in combination with transcutaneous electric nerve stimulation, heating pad, or topical capsaicin in the treatment of patients with MPS of the upper trapezius.

Conditions
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Myofascial Pain Syndrome of the Upper Trapezius

Intervention / Treatment
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* Drug: NSAID patch
* Drug: NSAID patch + transcutaneous electric nerve stimulation
* Drug: NSAID patch + heating pad
* Drug: NSAID patch + topical capsaicin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients over 20 years of age with diagnosis of myofascial pain syndrome of the upper trapezius. Visual analogue scale (VAS, 0 = no pain, 10 = worst pain) greater than Exclusion Criteria: 1. Pregnant or breast feeding women, patients who have taken opioids within seven days, patients with severe disease (heart disease, liver disease, etc) that might affect the results of the study, patients who have participated in another clinical study within 30 days.

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: NSAID patch group<br>administer the NSAID patch | Drug: NSAID patch<br> <br> |
| Experimental: NSAID patch + transcutaneous electric nerve stimulation group<br> | Drug: NSAID patch + transcutaneous electric nerve stimulation<br>* The patients of the experimental groups will be divided in to three groups according to what they are administered: NSAID patch plus transcutaneous electric nerve stimulation, NSAID patch plus heating pad, and NSAID patch plus topical capsaicin. All the groups will be observed for two weeks.<br>|
| Experimental: NSAID patch + heating pad group<br> | Drug: NSAID patch + heating pad<br>* The patients of the experimental groups will be divided in to three groups according to what they are administered: NSAID patch plus transcutaneous electric nerve stimulation, NSAID patch plus heating pad, and NSAID patch plus topical capsaicin. All the groups will be observed for two weeks.<br>|
| Experimental: NSAID patch + topical capsaicin group<br> | Drug: NSAID patch + topical capsaicin<br>* The patients of the experimental groups will be divided in to three groups according to what they are administered: NSAID patch plus transcutaneous electric nerve stimulation, NSAID patch plus heating pad, and NSAID patch plus topical capsaicin. All the groups will be observed for two weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The differences of the VAS pain scores |  | 2weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Capsaicin, myofascial pain syndrome, non-steroidal anti-inflammatory agents, transcutaneous electric nerve stimulation