linjc16/ctgov huggingface dataset:
Elidel-Study: Elidel in Patients With Atopic Dermatitis

Study Overview
=================
Brief Summary
-----------------
Atopic dermatitis is a common disease. Emollients and Elidel have both shown to be effective to treat this disease. The research question is, whether the effective component (Elidel) is better than the emollient to improve the skin function.

Official Title
-----------------
Control of Therapy With Elidel vs Placebo in Patients With Atopic Dermatitis Using Bioengineering Methods

Conditions
-----------------
Atopic Dermatitis

Intervention / Treatment
-----------------
* Drug: Elidel-Creme


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > 18 years Atopic dermatitis on both lower arms at least 1% body surface area. Atopic Dermatitis Severity Index (ADSI)-Score >= 6 Investigator Global Assessment (IGA)-Score >= 2 Exclusion Criteria: Systemic therapy with immunosuppressive drugs within the past 24 weeks Phototherapy against atopic dermatitis. Antibiotic therapy against atopic dermatitis. Allergy against Elidel. Pregnancy Nursing Skin cancer

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Elidel-Creme|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Atopic dermatitis on both lower arm.
Ultrasound-guided Quadratus Lumborum Block for Postoperative Pain Relief After Cesarean Delivery

Study Overview
=================
Brief Summary
-----------------
The Quadratus Lumborum (QL) Block is an ultrasound-guided technique described by Rafael Blanco in 2007. The nerves to the lower abdominal wall can be anesthetized by injecting local anesthetics close to the anterior border of the quadratus lumborum muscle. In our randomized, controlled, double-blinded study ultrasound-guided QL-blocks in 20 female patients after cesarean delivery will be compared with a placebo control group of 20 patients to investigate analgesic consumption, pain level, opioid related side effects and mobilization.

Official Title
-----------------
Ultrasound-guided Quadratus Lumborum Block for Postoperative Pain Relief After Cesarean Delivery

Conditions
-----------------
Postoperative Pain

Intervention / Treatment
-----------------
* Procedure: nerve block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with cesarean delivery American Society of Anesthesiologists classification (ASA) < 3 adequate communication skills Body mass index < 32 Exclusion Criteria: ASA > 2 chronic pain neurological illness/ neuropathy contraindication against local anesthetics

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: quadratus lumborum block (nerve block)<br>quadratus lumborum block with ropivacaine | Procedure: nerve block<br>* quadratus lumborum block<br>* Other names: quadratus lumborum block;|
| Placebo Comparator: sham block<br>QL block with saline | Procedure: nerve block<br>* quadratus lumborum block<br>* Other names: quadratus lumborum block;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| morphine consumption |  | 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pain level (NRS) |  | 48 hours |
Physician's Comfort Level and Satisfaction Study With The e2TM Collector Compared to the Spatula/CytoBrush Technique

Study Overview
=================
Brief Summary
-----------------
A study which assesses the physician's comfort level and satisfaction when using the e2TM Collector compared to the Spatula/SytoBrush technique.

Official Title
-----------------
Clinical Study Assessing Physician's Comfort Level and Satisfaction When Using The e2TM Cervical Cell Collector Compared to the Standard Spatula/CytoBrush Technique

Conditions
-----------------
Cervical Cell Collection

Intervention / Treatment
-----------------
* Device: e2TM Cervical Cell Collector


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Every Physician who will participate in the two CytoCore prospective studies assessing the safety and efficacy of the e2TM Collector Each physician will have used the Collector 15 - 25 times Each physician will have signed the Consent form prior to using the Collector for the first time. Exclusion Criteria: None (commensurate with the above inclusion conditions.)
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: e2TM Cervical Cell Collector|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Physician comfort level and satisfaction when using the e2TM Collector compared to the standard spatula/cytobrush. |  | Each physician will be surveyed after first and last use of the e2TM collector as well as three more times spaced at near regular intervals in between. |
A Study of Nasopharyngeal Carcinoma From Guangdong

Study Overview
=================
Brief Summary
-----------------
This prospective cohort study aims to establish prognostic models, to discover toxicity associated predictors and to validate randomized trials in clinical practice.

Official Title
-----------------
A Prospective Cohort Study of Nasopharyngeal Carcinoma to Establish Prognostic Models, to Discover Toxicity Associated Predictors and to Validate Randomized Trials in Clinical Practice

Conditions
-----------------
Nasopharyngeal Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: histological confirmed nasopharyngeal carcinoma; scanned by magnetic resonance imaging from calvaria vertex to clavicles before treatment; pretreatment Epstein-Barr virus deoxyribonucleic acid copy number is available; irradiated with intensity-modulated radiotherapy; Exclusion Criteria: finishing anticancer therapy in two or more hospitals; pregnancy or lactation; diagnosed with other sort of cancer before or during the treatment.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| in clinical trials<br> | |
| out of clinical trials<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| overall survival |  | 3-years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants with treatment-related acute adverse events as assessed by CTCAE v4.0 |  | 30-days |
Effects of a Minimal-Contact Lifestyle Intervention on Physical Activity, Diet, and Body Weight

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to conduct a pilot randomized controlled trial, to determine whether providing financial incentives for meeting daily step goals (a) increases the daily step counts of participants, (b) increases compliance with the overall program (including diet recommendations), and (c) increases weight loss.

Official Title
-----------------
Effects of a Minimal-Contact Lifestyle Intervention on Physical Activity, Diet, and Body Weight

Conditions
-----------------
Weight Loss

Intervention / Treatment
-----------------
* Behavioral: Daily step goal financial incentive
* Behavioral: Standard of Care


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: required to be able to read. required to have access to a computer. required to have a body mass index between 27 and 45 kg.m-2. required to take fewer than 7,000 steps per day at baseline (as determined by a pedometer, averaged across 4-7 days). Exclusion Criteria: Individuals who report having an injury or physical limitation that renders them unable to walk ¼ mile without difficulty. Uncontrolled cardiovascular or metabolic condition determined by health history questionnaire.

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Daily step goal financial incentive<br> | Behavioral: Daily step goal financial incentive<br>* Participants' daily activity was incentivized. Reaching a predetermined/individualized step goal each day resulted in 1.00 per day.<br>|
| Active Comparator: Control, Standard of Care<br> | Behavioral: Standard of Care<br>* Standard payment of 70.00 at the beginning of the study. Participants' daily activity was not incentivized.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Daily Step Count | Change in steps/day from week 1 to week 12. | Change from week 1 to week 12 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Program Compliance | Compliance with the physical activity prescription, means meeting or exceeding the step goal for that day. Participants' compliance was assessed by totaling the number of days they met their step goal and dividing it by the total number of days of the intervention. Thus, providing investigators the percentage of days that each participant complied with their physical activity prescription. | Change from week 1 to week 12 |
Tranilast Plus Allopurinol in Patients With Moderate to Severe Gout (TAnGO)

Study Overview
=================
Brief Summary
-----------------
This Phase 2 study will be a multicenter, double-blind, randomized, active-comparator study to evaluate the safety and efficacy of tranilast in combination with allopurinol in patients with hyperuricemia and moderate to severe gout.

Official Title
-----------------
A Randomized, Double-Blind, Parallel Group Study to Evaluate the Safety and Efficacy of Tranilast in Combination With Allopurinol in Patients With Moderate to Severe Gout (TAnGO)

Conditions
-----------------
Moderate to Severe Gout, Hyperuricemia

Intervention / Treatment
-----------------
* Drug: Combination 400
* Drug: Allopurinol
* Drug: Combination 600


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female, aged 18 to 80 Severe gout, demonstrated by 3 or more gout flares in the previous 12 months, or the presence of at least one gout tophus or gouty arthritis Hyperuricemia with a sUA ≥8.0 mg/dL Exclusion Criteria: Pregnant or nursing Known hypersensitivity to any of the components of tranilast or allopurinol Known history of xanthinuria or kidney stones Use of an investigational drug within 30 days Presence of, or history of, cancer with the exception of completely excised, non-metastatic squamous cell and basal cell carcinomas of the skin Subject is planning or likely to require a surgical procedure during the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Allopurinol<br>Allopurinol | Drug: Allopurinol<br>* Allopurinol 400 mg, QD<br>|
| Experimental: Combination 400<br>Tranilast and Allopurinol | Drug: Combination 400<br>* Tranilast 300 mg QD; Allopurinol 400 mg QD<br>|
| Experimental: Combination 600<br>Tranilast and Allopurinol | Drug: Combination 600<br>* Tranilast, 300 mg QD; Allopurinol 600 mg QD<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percent change from baseline in serum uric acid (sUA) levels |  | 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Proportion of subjects whose sUA levels fall below 6.0 mg/dL following 4 weeks of dosing |  | 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Moderate to severe gout, Hyperuricemia
Clinical Evaluation of the Care On Line Thermometer

Study Overview
=================
Brief Summary
-----------------
The purpose of this clinical study is to evaluate the performance of the COL thermometer by comparing its measurement to equilibrium measurement and to make a final tuning of the thermometer algorithm.

Conditions
-----------------
Healthy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children (1-18 years old) in the pediatric or emergency department, with or without fever. An informed consent was signed by the patient's guardian. Exclusion Criteria: The medical staff decides that participating will damage patient recovery.

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Temperature measurement
Measuring Intraabdominal Pressure, Lactic Acid, and Urine Output

Study Overview
=================
Brief Summary
-----------------
This study serves as a pilot study with the intention to to measure intraabdominal pressure, lactic acid, and urine output in obese individuals undergoing laparoscopic inguinal hernia repair. By measuring these values, the investigators aim to look for correlations between metrics and determine an accurate and precise measurement of IAP during laparoscopic hernia surgery using the Accuryn Monitoring System. By obtaining accurate and precise measurements of IAP during surgery the investigators will be to compare measurements to previous IAP data obtained during daily activities and strenuous movements and any associations with inguinal hernia recurrence.

Official Title
-----------------
Measuring Intraabdominal Pressure, Lactic Acid, and Urine Output in Obese Individuals Undergoing Laparoscopic Inguinal Hernia Repair

Conditions
-----------------
Intra-Abdominal Hypertension, Inguinal Hernia

Intervention / Treatment
-----------------
* Device: Accuryn Monitoring System


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Obese with BMI > 30 Diagnosis of inguinal hernia Qualify for laparoscopic inguinal hernia repair Exclusion Criteria: Previous bowel resections resulting in short bowel Extensive abdominal scarring BMI < 30 Fail to qualify for laparoscopic inguinal hernia repair

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Accuryn Monitoring System|Utilization of the Accuryn Monitoring System to measure intraabdominal pressure and urine output during laparoscopic inguinal hernia repair surgery.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraabdominal Pressure | Maximum IAP levels during surgery | 2 hours |
Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients

Study Overview
=================
Brief Summary
-----------------
Of all emergency room patients, persons presenting with encephalitis/meningitis syndrome of a potentially infectious nature are among those of greatest concern. Routine clinical and laboratory evaluation of such patients involves screening for known infectious disease agents, selection of which is nonstandardized. Progress in diagnostic technologies, especially molecular techniques based on genetic characteristics of potential pathogens, has greatly expanded the investigators capacity to evaluate specimens from patients for a much wider range of potential pathogens (bacterial, viral, fungal and parasitic agents). Use of Polymerase Chain Reaction (PCR) technology offers the possibility of identifying causative agents for the approximately 50% of all such presentations which go un-diagnosed. The investigators propose a study involving a collaboration between the EMERGEncy ID NET, a network of 10 geographically diverse university-affiliated urban emergency departments (coordinated by Olive View-UCLA Medical Center) and the Centers for Disease Control and Prevention (CDC), to use these new technologies to address this issue.

Conditions
-----------------
Meningoencephalitis, Other Syndromes Requiring Lumbar Puncture in Emergency Department

Intervention / Treatment
-----------------
* Other: no intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > or = 3 months old Receiving a Lumbar Puncture in the emergency department as part of their standard care. Exclusion Criteria: No CSF available

Ages Eligible for Study
-----------------
Minimum Age: 3 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with syndromes requiring lumbar puncture<br> | Other: no intervention<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of pathogens | We will describe the range and proportion of pathogens found in CSF among patients enrolled over a 2 year period. | 2 years |
Joint Outcome Study

Study Overview
=================
Brief Summary
-----------------
This study examines the progression of joint disease in children with hemophilia assigned to either standard treatment or enhanced therapy.

Official Title
-----------------
A Clinical Trial of Primary Prophylaxis Against Joint Disease in Children With Severe Hemophilia

Conditions
-----------------
Hemophilia A

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosed with hemophilia A factor level less than 2% Exclusion Criteria: More than 2 bleeds into the same joint

Ages Eligible for Study
-----------------
Minimum Age: 1 Year
Maximum Age: 30 Months

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Oral Health and Pregnancy

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to identify the knowledge, behavior and social representation on dental health among pregnant women. This study could improve, in the future, prevention, treatments and care for them.

Detailed Description
-----------------
Pregnant women will have to complete a questionnaire that brings together their knowledge, practices and social representations of oral health during their current pregnancy.

Official Title
-----------------
Oral Health and Pregnancy : Relation Between Knowledge, Practices and Social Representation of Pregnant Women in the Gynecologie Department at the Montpellier's CHRU

Conditions
-----------------
Dental Caries, Pregnancy Related

Intervention / Treatment
-----------------
* Behavioral: psychotherapy, lifestyle counseling


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: pregnant t women over 18 years old French language Exclusion criteria: - pregnant women under 18 years old

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pregnant women over 18 years old coming to consult at the gynecology department<br>Pregnant women over 18 years old coming to consult at the gynecology department in the Montpellier's hospital | Behavioral: psychotherapy, lifestyle counseling<br>* psychotherapy, lifestyle counseling<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate the knowledge | Evaluate the knowledge on the oral health among pregnant woman | 1 day | 
| Evaluate the practices | Evaluate the practices on the oral health among pregnant woman | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluate the social representation | Evaluate the social representation on the oral health among pregnant woman | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Oral hygiene, Public Health, Pregnancy, Prevention, Patients coming to the CHU ADV Montpellier for consultation, Pregnant patients, Knowledge, Literacy