Enhancing Cognitive Abilities With Comprehensive Training

Study Overview
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Brief Summary
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The purpose of this study is to measure the efficacy of an online cognitive training program against an active control condition in a large, randomized trial.

Detailed Description
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The present study aims to evaluate a targeted, progressively challenging, online cognitive training program comprised of 49 distinct exercises targeting a variety of cognitive capacities. The cognitive training program will be compared to a plausibly beneficial active control condition in which participants completed online crossword puzzles. The investigators hypothesize that the cognitive training will show greater transfer to a range of underlying cognitive abilities than the active control, as measured by a broad battery of neuropsychological assessments and participant-reported outcomes.

Official Title
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Enhancing Cognitive Abilities With Comprehensive Training: A Large, Online, Randomized, Active-Controlled Trial

Conditions
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Cognitive Abilities

Intervention / Treatment
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* Other: Lumosity Cognitive Training
* Other: Crossword Puzzles


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Engaged with the Lumosity program at least 3 days in the first week after sign-up Access to an internet enabled computer to complete training Exclusion Criteria: Paying subscriber

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cognitive Training<br>Lumosity cognitive training program. | Other: Lumosity Cognitive Training<br>* adaptive online cognitive training<br>|
| Active Comparator: Crossword Puzzles<br>Timed online crossword puzzles | Other: Crossword Puzzles<br>* timed online crossword puzzles<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Aggregate Cognitive Performance | Aggregate cognitive performance, as measured by Grand Index, on seven neuropsychological assessments (Forward Memory Span, Reverse Memory Span, Grammatical Reasoning, Progressive Matrices, Go/No-Go, Arithmetic Reasoning, Two-Target Search) | Baseline to 10 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Participant-Reported Outcomes | 9 questions related to everyday cognition and emotional status. | Baseline to 10 weeks | 
| Individual Neuropsychological Assessments composite | Separate analyses of changes on each of the seven neuropsychological assessments in the battery (Forward Memory Span, Reverse Memory Span, Grammatical Reasoning, Progressive Matrices, Go/No-Go, Arithmetic Reasoning, Two-Target Search). | Baseline to 10 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lumosity, Cognitive Training, Crossword Puzzles