Comparison of Onset of Neuromuscular Blockade With Electromyographic and Acceleromyographic Monitoring

Study Overview
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Brief Summary
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The purpose of this research is to use 2 devices to compare the difference in the amount of time it takes for each device to register complete muscle relaxation after the muscle relaxing medication is given. The comparison will be made by using electromyographic (EMG), such as TetraGraph, and acceloromyographic (AMG), such as TOFScan, monitors at the time of insertion of breathing tube.

Official Title
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Comparison of Onset of Neuromuscular Blockade With Electromyographic and Acceleromyographic Monitoring: A Prospective, Randomized Trial

Conditions
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Neuromuscular Blockade

Intervention / Treatment
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* Device: Train of four measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients willing to participate and provide an informed consent. Patients undergoing elective surgical procedures that require use of NMBA agents (rocuronium) administered intraoperatively. Exclusion Criteria: Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury. Patients with systemic neuromuscular diseases such as myasthenia gravis. Patients with significant organ dysfunction that can significantly affect pharmacokinetics of neuromuscular blocking and reversal agents; i.e., severe renal impairment or end-stage liver disease. Patients having surgery that would involve prepping the arm into the sterile field. Patients receiving a rapid sequence induction.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Dominant hand<br>Application of either TetraGraph or TOFScan device on dominant hand | Device: Train of four measurement<br>* Use of either TetraGraph or TOFScan to measure the neuromuscular blockade<br>|
| Non-Dominant hand<br>Application of either TetraGraph or TOFScan device on non-dominant hand | Device: Train of four measurement<br>* Use of either TetraGraph or TOFScan to measure the neuromuscular blockade<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time difference | Compare time difference from neuromuscular blockade agent administration to neuromuscular blockade onset | During the initiation of anesthesia period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intubating conditions | Assess intubating conditions once a complete neuromuscular blockade has been achieved either by TetraGraph or TOFScan measurements | During the initiation of anesthesia period | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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neuromuscular blockade