Quantification of Nerve Stiffness in Neuropathies

Study Overview
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Brief Summary
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This project aims to understand how nerve mechanical properties are altered in patients with rare peripheral neuropathies . Stiffness of various peripheral nerves will be measured using ultrasound shear wave elastography. Patients will be compared with age-matched controls.

Detailed Description
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The following nerve will be studied bilaterally, in a randomised order: Median, ulnar, Radial, Sciatic and Tibial. Participants will be asked to remain relaxed during elastography measurements.

Official Title
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Quantification of Nerve Stiffness in Patients With Peripheral Neuropathies

Conditions
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Chronic Inflammatory Demyelinating Polyneuropathy, Charcot-Marie-Tooth Disease, Type IA, Anti-MAG Neuropathy

Intervention / Treatment
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* Other: elastography measurements


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or female aged 18 to 65 Having social insurance status Having given informed consent Diagnostic of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), CMT1a or Anti-MAG (peak immunoglobulin M (IGm)>15,000 BTU) Exclusion Criteria: For controls: Person staying in a health or social facility Person unable to understand the protocol and to respect the modalities Person deprived of liberty Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice) Participation in another biomedical research in progress Diabetes, history of neuromuscular disease For CIDP: Person staying in a health or social facility Person unable to understand the protocol and to respect the modalities Person deprived of liberty Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice) Participation in another biomedical research in progress MRC score < 3 For Charcot-Marie-Tooth type 1 (CMT1) and anti-MAG: Person staying in a health or social facility Person unable to understand the protocol and to respect the modalities Person deprived of liberty Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice) Participation in another biomedical research in progress

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patients with peripheral neuropathies<br>This project aims to understand how nerve mechanical properties are altered in patients with rare peripheral neuropathies . Stiffness of various peripheral nerves will be measured using ultrasound shear wave elastography. Patients will be compared with age-matched controls. | Other: elastography measurements<br>* elastography measurements<br>|
| Other: controls<br> | Other: elastography measurements<br>* elastography measurements<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| nerve shear wave velocity | Ultrasound shear wave elastography will provide a measure of nerve shear wave velocity, which will be used as a surrogate of nerve stiffness. | Day0 |