Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia

Study Overview
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Brief Summary
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The research will be retrospective, and will include all patients who were admitted during 2020 and 2021 in the COVID-19 ICU of University Hospital Center Osijek due to pneumonia caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The association of chest x-ray infiltrate evolution with changes in laboratory inflammatory parameters and respiratory function parameters will be examined.

Detailed Description
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The research will be retrospective, and will include a review of medical history of all patients admitted in the COVID-19 ICU of the University hospital Osijek during 2020 and 2021. Associated comorbidity, hospital admission date, intubation date, mechanical ventilation, extubation, discharge, and patient final outcome will be recorded for each patient. By analyzing X-rays of the lungs by radiology specialists, inflammatory infiltrates in the lungs will be quantified via the Brixia system, during hospital admission, admission to the Respiratory Center, and during treatment at the Respiratory Center. All patients will have their Sequential Organ Failure Assessment (SOFA) and/or Acute Physiology and Chronic Health Evaluation (APACHE II) values calculated upon admission. Inflammatory parameters (c-reactive protein (CRP), procalcitonin (PCT), interleukine-6 (IL-6), ferritin), red blood cell count, leukocytes, blood urea nitrogen (BUN), arterial blood gases and ventilation parameters on admission to the hospital, admission to the ICU, and on several occasions during treatment in the ICU will be analysed. Also, empirical use of antibiotics, the occurrence of bacterial superinfections, sepsis and organic failure will be noted.

Official Title
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Radiographic Severity Scoring System and Clinical and Laboratory Evolution of COVID-19 Pneumonia

Conditions
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COVID-19 Pneumonia, Sepsis, SARS-CoV-2 Acute Respiratory Disease, Pneumonia, Multiorgan Failure

Intervention / Treatment
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* Diagnostic Test: Chest X-ray


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pneumonia caused by SARS-CoV-2 virus Admission to the ICU COVID-19 unit Exclusion Criteria: - Patients with lung tumors or history of lung resection

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COVID-19 pneumonia patients<br>Patients treated at the University Hospital Osijek Respiratory Center with pneumonia caused by SARS-CoV-2 | Diagnostic Test: Chest X-ray<br>* Retrospective analysis of chest x-rays of patients with COVID-19<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Chest x-ray severity score | The influence of the dynamics of radiographic changes quantified by Brixia score on the outcome of COVID-19 patients will be examined | 21 days | 
| Inflammatory markers | The influence of serum levels of inflammatory parameters, and clinical and laboratory indicators of organic failure on chest x-ray severity score will be examined | 21 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COVID-19, Acute respiratory distress syndrome (ARDS), Sepsis, Multiorgan Failure, Chest X-ray, Inflammation