Nationwide Treatment Survey of Intracranial Arteriovenous Malformation in China

Study Overview
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Brief Summary
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This register study will collect the treatment information of the intracranial arteriovenous malformation patients in China. We aim to understand the current treatment situation of the disease in China.

Detailed Description
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Intracranial arteriovenous malformations are congenital lesions that consist of multiple arteries and veins, connecting as a fistula without intervening normal capillary bed. The treatment strategy including surgical removal, endovascular embolism and stereotaxic radiosurgery and comprehensive treatment. China is a united multi-ethnic nation of 56 ethnic groups, and has the largest population in the world. We have most extensive and valuable clinical resources of intracranial arteriovenous malformation in the world. But we know little about the current treatment situation of the disease in China. In order to realize the treatment situation of intracranial arteriovenous malformation in China, we designed a retrospective and prospective register study to collect the treatment and outcome information all over China.

Official Title
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A Nationwide Treatment Survey of Intracranial Arteriovenous Malformation: a Multicenter Retrospective and Prospective Register Study in China

Conditions
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Intracranial Arteriovenous Malformations

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All the patients that diagnosed of intracranial AVM by DSA/CT/MRI All patients gave written informed consent Exclusion Criteria: patients refuse to attend the survey
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Surgical treatment<br>Surgical resection of intracranial arteriovenous malformations. | |
| Stereotaxic radiosurgery<br>Deliver a relatively high dose of focused radiation precisely to the arteriovenous malformations. | |
| Endovascular treatment<br>Deliver embolic materials to the feeding arteries or the nidus by microcatheters | |
| Comprehensive treatment<br>Use two or three methods ( Surgical treatment stereotaxic radiosurgery endovascular treatment ) to cure the intracranial arteriovenous malformations | |
| Conservative treatment<br>Patients refused to any of the treatment above | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| modified Ranking Scale | The scale runs from 0-6, running from perfect health without symptoms to death. 0 - No symptoms. - No significant disability. Able to carry out all usual activities, despite some symptoms. - Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities. - Moderate disability. Requires some help, but able to walk unassisted. - Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted. - Severe disability. Requires constant nursing care and attention, bedridden, incontinent. - Dead | six months after operation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment complications | Post operative epilepsy seizure, hemorrhage,infarction;cerebral edema、endovascular embolization injury | six months after treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Intracranial Arteriovenous Malformations, Surgical removal, Endovascular embolism, Stereotaxic radiosurgery, Outcomes