Anterior Segment Imaging With Ultrahigh-resolution OCT in Patients With Glaucoma and PEX - a Pilot Study

Study Overview
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Brief Summary
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The aim of the present study is to develop a measurement protocol for optimal imaging of the anterior segment of the eye, including anterior chamber angle, Schlemm's canal, filtering bleb and pseudoexfoliation deposits on the lens based on measurements in patients with glaucoma and PEX. In glaucoma the structures of the anterior chamber are important for classification, therapy, progression and prognosis and imaging of the angle between the iris and the cornea is the key for open angle and closed angle glaucoma differential diagnosis. For this purpose, a customized ultrahigh resolution Spectral Domain OCT will be used to validate whether the protocol can also be more widely applied in these patients. Based on the obtained measurement protocol, further studies investigating anatomy and pathophysiology of the anterior segment of the eye as well as surgical outcome in patients with glaucoma and PEX can be planned. The aim of the study is to develop a measurement protocol for OCT imaging and characterization of the anterior chamber in glaucoma patients.

Official Title
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Anterior Segment Imaging With Ultrahigh-resolution OCT in Patients With Glaucoma and Pseudoexfoliation Syndrome - a Pilot Study

Conditions
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Glaucoma

Intervention / Treatment
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* Drug: Pilocarpine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women aged over 18 years For patients with primary open angle glaucoma: Diagnosed primary open angle glaucoma Visual field defects and optic nerve head appearance characteristic for glaucoma Open anterior chamber angle as evidenced by gonioscopy No previous glaucoma surgery No previous cataract surgery For patients with primary angle closure: Angle closure predisposition as evidenced from goniosocopy No previous glaucoma surgery For patients with neovascular glaucoma: - Neovascularization in the anterior chamber angle For patients with pseudoexfolation deposits on the lens: PEX glaucoma as evidenced from slit lamp examination Visual field defects and optic nerve head appearance characteristic for glaucoma Open anterior chamber angle as evidenced by gonioscopy No previous glaucoma or cataract surgery For glaucoma patients with filtering bleb after trabeculectomy: Patients with history of trabeculectomy secondary to open angle glaucoma in the previous three months No cataract surgery For healthy volunteers: No evidence of ocular disease No degenerative changes in the retina in funduscopy after mydriasis Ametropia less than 3 dpt. Exclusion Criteria: Presence of any abnormalities preventing reliable measurements as judged by the investigator Pregnancy, planned pregnancy or lactating Ocular inflammation and ocular disease interfering with the study aims as judged by the investigator

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: primary open angle glaucoma patients<br> | |
| No Intervention: patients with primary angle closure<br> | |
| No Intervention: patients with neovascular glaucoma<br> | |
| No Intervention: PEX glaucoma patients<br> | |
| No Intervention: glaucoma patients with filtering bleb<br> | |
| Experimental: healthy volunteers<br>instillation of antiglaucoma treatment in the study eye | Drug: Pilocarpine<br>* topical instillation into the study eye<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 3-dimensional imaging of the anterior eye segment |  | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Schlemm's canal lumen area, PEX