Effects of Recurrent PE on Women and Offspring

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the risk factors of recurrent preeclampsia and compare the short-term and long-term adverse outcomes of women and their offspring.

Detailed Description
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The investigators collected women delivered twice in a row in our hospital. The investigators divided these pregnant women into three groups. Women in the first group did not complicate preeclampsia at both deliveries; Women in the second group complicated preeclampsia at the first delivery or at the second delivery; women in the third group complicated preeclampsia at two deliveries. The investigators explore the risk factors of recurrent preeclampsia and measure blood pressure, blood lipids, thyroid function, glycosylated hemoglobin, ALT, AST, et al. in one year, three years, and five years after the second delivery.

Official Title
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The Effects of Recurrent PE on Women and Offspring's Health

Conditions
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Recurrence, Preeclampsia, Hypertension

Intervention / Treatment
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* Other: blood pressure,BMI, blood sample


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: women with at least twice of delivery history Exclusion Criteria: women with chronic hypertension

Ages Eligible for Study
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Minimum Age: 19 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| control<br>pregnancy without preeclampsia | Other: blood pressure,BMI, blood sample<br>* Blood pressure will be monitored. BMI will be measured. Blood samples will be tested.<br>|
| preeclampsia<br>pregnancy complicated with preeclampsia at the first delivery or at the second delivery | Other: blood pressure,BMI, blood sample<br>* Blood pressure will be monitored. BMI will be measured. Blood samples will be tested.<br>|
| recurrent preeclampsia<br>pregnancy complicated with preeclampsia at two deliveries | Other: blood pressure,BMI, blood sample<br>* Blood pressure will be monitored. BMI will be measured. Blood samples will be tested.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blood pressure and hypertension of women | blood pressure ≥140/90 mmHg | 1year after the second deliver | 
| blood pressure and hypertension of women | blood pressure ≥140/90 mmHg | 3 years after the second deliver | 
| blood pressure and hypertension of women | blood pressure ≥140/90 mmHg | 5 years after the second deliver | 
| blood pressure and hypertension of offspring | blood pressure≥140/90 mmHg | 1 year old | 
| blood pressure and hypertension of offspring | blood pressure≥140/90 mmHg | 3 years old | 
| blood pressure and hypertension of offspring | blood pressure≥140/90 mmHg | 5 years old | 
| level of glycosylated hemoglobin in blood | women | 1 year after the second deliver | 
| level of glycosylated hemoglobin in blood | women | 3 years after the second deliver | 
| level of glycosylated hemoglobin in blood | women | 5 years after the second deliver | 
| level of cholesterol, LDL, HDL, VLDL-C in blood | women | 1 year after the second deliver | 
| level of cholesterol, LDL, HDL, VLDL-C in blood | women | 3 years after the second deliver | 
| level of cholesterol, LDL, HDL, VLDL-C in blood | women | 5 years after the second deliver | 
| level of FT3,FT4, and hTSH in blood | women | 1year after the second deliver | 
| level of FT3,FT4, and hTSH in blood | women | 3 years after the second deliver | 
| level of FT3,FT4, and hTSH in blood | women | 5 years after the second deliver | 
| level of AST and ALT in blood | women | 1year after the second deliver | 
| level of AST and ALT in blood | women | 3 years after the second deliver | 
| level of AST and ALT in blood | women | 5 years after the second deliver | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| BMI of offspring | weight(kg)/height(m)2 | 1 year old | 
| BMI of offspring | weight(kg)/height(m)2 | 3 years old | 
| BMI of offspring | weight(kg)/height(m)2 | 5 years old | 
| level of insulin in blood | women | 1year after the second deliver | 
| level of insulin in blood | women | 3 years after the second deliver | 
| level of insulin in blood | women | 5 years after the second deliver | 
| level of fructosamine in blood | women | 1year after the second deliver | 
| level of fructosamine in blood | women | 3 years after the second deliver | 
| level of fructosamine in blood | women | 5 years after the second deliver | 
| level of AI37℃、AI4℃、PRA、ALD、AngII in blood | women | 1 year after the second deliver | 
| level of AI37℃、AI4℃、PRA、ALD、AngII in blood | women | 3 years after the second deliver | 
| level of AI37℃、AI4℃、PRA、ALD、AngII in blood | women | 5 years after the second deliver |