Impact of Hand Osteoarthritis on Arterial Stiffness

Study Overview
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Brief Summary
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Patients affected by osteoarthritis (OA) have an increase overall mortality compared to the general population, mainly due to cardiovascular diseases. OA patients without cardiovascular risk have a 10 years cardiovascular events higher of around 15-30 %. Although the molecular mechanisms are still not well known, the structure and function of the vessel wall can be affected by several inflammatory and metabolic parameters during OA.These functional and structural changes of the arterial wall leads to arterial stiffness, measured by the pulse-wave velocity (PWV). PWV is the most widely used technique to assess arterial stiffness and has been shown to have predictive value for morbidity and mortality. In our study, we planned to compare arterial stiffness in OA patients with healthy subjects.

Official Title
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Impact of Hand Osteoarthritis on Arterial Stiffness

Conditions
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Osteoarthritis

Intervention / Treatment
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* Other: arterial stiffness measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with clinical hand OA defined according to the ACR (American College of Rheumatology) criteria. Patients with radiographic hand OA defined according to the Kellgren Lawrence criteria (≥ 2). Steady dose of statins for at least one month. Subject affiliated to a social security scheme Written informed consent Exclusion Criteria: Rheumatoid arthritis, psoriatic arthritis or other inflammatory arthritis diseases. History of arterial hypertension treated and / or uncontrolled (SBP > 140 mmHg and DBP (diastolic blood pressure) > 90 mmHg) Diabetes (fasting blood glucose > 7 mmol/L) Obesity (BMI > 35 kg/m²) Chronic renal failure defined by a glomerular filtration rate <60 ml/min/1,73m ². Patient with uncontrolled cardiovascular disease or a personal history of cardiovascular events (myocardial infarction and angina, occlusive arterial disease, stroke) Pregnant or breastfeeding, or premenopausal and not taking an effective contraception

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Screening
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: hand oa patients<br>assess the carotid-femoral arterial stiffness determined by measuring the PWV | Other: arterial stiffness measurement<br> <br> |
| Active Comparator: without Hand OA patients<br>assess the carotid-femoral arterial stiffness determined by measuring the PWV | Other: arterial stiffness measurement<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| carotid-femoral arterial stiffness | To assess the carotid-femoral arterial stiffness determined by measuring the PWV in patients with hand OA compared to healthy subjects. | within the first 15 days after inclusion |