Behavioral and Neurophysiological Effects of Multichannel Executive Network tDCS Combined With Preferred Music Stimulation

Study Overview
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Brief Summary
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This study aims at comparing the effects of transcranial direct current stimulation combined with music on neurophysiological outcomes in healthy participants. This study also aims to evaluate the effects of tDCS combined with music on cognition.

Official Title
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Behavioral and Neurophysiological Effects of Multichannel Executive Network tDCS Combined With Preferred Music Stimulation

Conditions
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Healthy

Intervention / Treatment
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* Device: tDCS
* Device: Sham tDCS
* Other: Music
* Other: White noise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy adults Exclusion Criteria: neurological disorders psychiatric disorders contra-indication to tDCS (eg, metallic brain implant, pacemaker) pregnancy alcool abuse active smoker

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: tDCS/music<br>active tDCS combined with music | Device: tDCS<br>* Multi-channel tDCS will be applied over the executive network for 20 minutes at 4mA<br>Other: Music<br>* Subjects will listen to their preferred music for 20 minutes<br>|
| Experimental: sham tDCS/music<br>Sham tDCS combined with music | Device: Sham tDCS<br>* Sham tDCS will consist of applying the same parameters as for active but the corresponding device will be turned off after 30 seconds as to simulate the initial sensation of the active current. A current of 2mA will still be used (but turned off after 30 sec). The electrodes that will be used will be the same as for the active tDCS condition and the electrodes placement as well.<br>Other: Music<br>* Subjects will listen to their preferred music for 20 minutes<br>|
| Experimental: tDCS/white noise<br>active tDCS combined with white noise | Device: tDCS<br>* Multi-channel tDCS will be applied over the executive network for 20 minutes at 4mA<br>Other: White noise<br>* Subjects will listen to a white noise for 20 minutes<br>|
| Experimental: sham tDCS/white noise<br>sham tDCS combined with white noise | Device: Sham tDCS<br>* Sham tDCS will consist of applying the same parameters as for active but the corresponding device will be turned off after 30 seconds as to simulate the initial sensation of the active current. A current of 2mA will still be used (but turned off after 30 sec). The electrodes that will be used will be the same as for the active tDCS condition and the electrodes placement as well.<br>Other: White noise<br>* Subjects will listen to a white noise for 20 minutes<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 3-back | The subject is presented with a sequence of stimuli, and the task consists of indicating when the current stimulus matches the one from 3 steps earlier in the sequence. | It will be measured over the course of four weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stroop | The subject has to name the font color of a printed word, while it can have a mismatch between the word and the color (ex: green is written in red). | It will be measured over the course of four weeks | 
| EEG - alpha power | Brain activity will be measured with an electroencephalography collected at rest. We will first look at the change in alpha power (8-12Hz) | It will be measured over the course of four weeks | 
| EEG - beta power | Brain activity will be measured with an electroencephalography collected at rest. We will also look at the change in other frequency bands (e.g., beta, theta, delta). | It will be measured over the course of four weeks |