linjc16/ctgov huggingface dataset:
Resistance Training to Improve Physical Function in the Elderly

Study Overview
=================
Brief Summary
-----------------
The primary purpose of this study is to examine the effectiveness of the current resistance training guidelines for older adults proposed by ACSM/AHA to improve physical function in individuals with reduced physical abilities. A randomized controlled intervention trial will be used to compare change in physical function pre- and post-intervention between a treatment group receiving the minimum recommendations of the guidelines and a control group asked not to change their physical activity participation. To better understand the clinical significance of such an occurrence, a secondary purpose was to determine if older adults with reduced physical abilities who adhere to the recommended intervention dosage will experience a change such that they can be reclassified to a more favorable level of functioning. It is hypothesized that the minimum recommended dosage of the guidelines would be sufficient to both improve physical function and improve functional classification in older adults with reduced physical abilities.

Official Title
-----------------
Efficacy of Resistance Training Guidelines to Improve Function in Older Adults

Conditions
-----------------
Physical Function

Intervention / Treatment
-----------------
* Behavioral: RT


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Older Adults aged >65yrs; reduced physical function Exclusion Criteria: Those with a history of resistance training

Ages Eligible for Study
-----------------
Minimum Age: 65 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Control<br> | Behavioral: RT<br>* 8 week RT Intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functionality | Change in Short Performance Physical Battery (SPPB) score is used as a measure of functionality. The SPPB consists of three tasks designed to assess gait speed, and ability to rise from a chair and maintain standing balance. This is a common test to assess function, with scores ranging from 0-12. The higher score equates to a better level of function. | 8 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Resistance Training, Physical Function, Older Adults
Study of Aripiprazole in the Treatment of Patients With Psychosis Associated With Dementia of the Alzheimer's Type

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to learn if aripiprazole is safe and effective in the treatment of psychosis associated with dementia of the Alzheimer's type.

Conditions
-----------------
Alzheimer Disease

Intervention / Treatment
-----------------
* Drug: aripiprazole


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Institutionalized patients with Alzheimer's

Ages Eligible for Study
-----------------
Minimum Age: 55 Years
Maximum Age: 95 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: aripiprazole|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Psychosis associated with dementia of the Alzheimer's type
Relationship Between the Gut Microbiota and Stress

Study Overview
=================
Brief Summary
-----------------
The relationship between the gut microbiota and stress is poorly studied in humans. In this study we aim to look for if stressed persons have different levels of key bacterial groups compared to the levels in non-stressed persons.

Detailed Description
-----------------
The gut microbial flora will be analyzed with molecular genetic methods. Stress will be measured with cortisol levels in saliva and with questionnaire.

Official Title
-----------------
Relationship Between the Gut Microbiota and Stress

Conditions
-----------------
Psychological Stress

Intervention / Treatment
-----------------
* Other: Observation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy man between 19-35 years old Exclusion Criteria: Antibiotic intake Gastrointestinal diseases Diabetes Phsycological diseases Tyroid related diseases Cardiovascular diseases Celiaki Cortisone drugs

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Observation in High-stressed<br>Saliva and fecal samples will be collected from High-stressed persons | Other: Observation<br>* Observation of the gut bacterial flora in high- and low-stressed individuals<br>|
| Observation in Low-stressed<br>Saliva and fecal samples will be collected from Low-stressed persons | Other: Observation<br>* Observation of the gut bacterial flora in high- and low-stressed individuals<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Markers of the gut microbiota |  | May 2015-January 2016 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Markers of stress |  | April 2015-January 2016 |
Multi-parametric Magnetic Resonance Imaging for Prostate Cancer Patients

Study Overview
=================
Brief Summary
-----------------
This is a pilot study of implement multi-parametric MR imaging for organ delineation and tumor response assessment of prostate cancer patients being treated with radiation therapy.

Detailed Description
-----------------
The study aims to generate intraprostatic lesions maps based on imaging, perform the treatment planning to compute the highest feasible simultaneous boosting dose to intraprostatic lesion and characterize longitudinal changes in imaging characteristics.

Official Title
-----------------
Pilot Study of Using Multi-parametric Magnetic Resonance Imaging for Organ Delineation and Tumor Response Assessment of Prostate Cancer Patients Being Treated With Radiation Therapy

Conditions
-----------------
Prostate Cancer

Intervention / Treatment
-----------------
* Device: Multiparametric MRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Histologically confirmed prostate adenocarcinoma Exclusion Criteria: Patients with metal fragments or implanted devices such as pacemakers and aneurysm clips are not eligible for the study considering
Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Multi-parametric MRI for Prostate Cancer<br>MRI will be acquired for prostate cancer patients undergoing radiation treatment. | Device: Multiparametric MRI<br>* MRI will be acquired before, during and after radiation treatment to evaluate treatment response<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Detection of Imaging Biomarkers to Localize the Intraprostatic Lesions and Predict Radiation Treatment Response | Identify the radiomics features selected from multimodal MRI to distinguish the dominant lesions from the normal tissues within the prostate. Track the changes of these features with longitudinal MRI scans to identify its correlation with the local control. | 2 years | 
| Tumor Response | Tumor response as measured by an increase in PSA. | 2 years |
Adipose Expression of Leptin, Adiponectin and IL-6 and Plasma Levels of Adipocytokines in Women With and Without Polycystic Ovary Syndrome (PCOS)

Study Overview
=================
Brief Summary
-----------------
The purpose of the study was to investigate adipose expression and plasma levels of different adipocytokine, which may play a role in the pathophysiology of PCOS. The investigators investigated lean and obese women with and without PCOS.

Official Title
-----------------
Adipocytokines in Lean and Obese Women With and Without PCOS

Conditions
-----------------
Polycystic Ovary Syndrome

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: women with PCOS according to the Rotterdam criteria Exclusion Criteria: other known diseases

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| lean women with PCOS<br> | |
| Obese women with PCOS<br> | |
| lean control women<br> | |
| Obese control women<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adipose expression of adipocytokines |  | From February 2004 -April 2006 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Plasma levels of adipocytokines |  | From February 2004-April 2006 |
Hyperbaric Oxygen Therapy and Angiogenesis in Diabetic Patients With Foot Ulcers

Study Overview
=================
Brief Summary
-----------------
Diabetic foot ulcers are a major cause of morbidity and mortality, accounting for approximately two-thirds of all non-traumatic amputations performed in the United States. The cost of foot ulcers in diabetic patients averages almost $28,000 for the two years after diagnosis of the ulcer. Hyperbaric oxygen (HBO) serves as primary or adjunctive therapy for a diverse range of medical conditions. HBO also has been used as an adjunct to antibiotics, debridement, and revascularization in the therapy of chronic, nonhealing wounds associated with diabetes or non-diabetic vascular insufficiency. The aim of the study is to assess whether hyperoxia induced angiogenesis in diabetic patients with foot ulcers.

Conditions
-----------------
Diabetic Foot Ulcers, Hyperbaric Therapy, Angiogenesis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 18 years or older, with type II diabetes suffering from foot ulcers admitted to the Institute of Hyperbaric Medicine and Wound Care Clinic at Assaf Harofeh Medical Center (Israel) Exclusion Criteria: Patients having chest pathology incompatible with pressure changes, inner ear disease, or suffering from claustrophobia, will be excluded from the study. Patients with significant macrovascular disease, defined as obstruction of more than 50% in the femoral or the popliteal arteries, will also be excluded from the study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Behavioural Intervention for Dysphagia in Acute Stroke

Study Overview
=================
Brief Summary
-----------------
Swallowing dysfunction after stroke is common, but there is no reliable evidence for how it should be managed other than perhaps by nasogastric tube. This study compared the effectiveness of standardised, low and high intensity behavioral intervention for dysphagia with that of usual care.

Detailed Description
-----------------
Stroke compromises swallowing function, causing dysphagia, in one quarter to one half of all patients. Dysphagia is associated with an increased risk of aspiration pneumonia, dehydration and malnutrition. Despite the development and implementation of several strategies of managing dysphagia after stroke, Few have been evaluated by means of randomised controlled trials. Comparisons: This study aims to compare stroke patients with dysphagia assigned to receive usual swallowing care, prescribed by the attending physician; standardised low intensity intervention comprising swallowing compensation strategies and diet prescription; or standardised high intensity intervention and dietary prescription .

Official Title
-----------------
A Randomised Controlled Trial of Dysphagia Therapies for Swallowing Disorders Following Stroke.

Conditions
-----------------
Dysphagia

Intervention / Treatment
-----------------
* Behavioral: behavioral swallowing exercises/ strategies


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: clinical diagnosis of stroke within the previous 7 days clinical diagnosis of swallowing difficulty Exclusion Criteria: no previous history of swallowing treatment no previous history of surgery of the head or neck

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: behavioral swallowing exercises/ strategies|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| survival free of an abnormal diet at 6 months |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| time to return to normal diet over the study |  |  | 
| recovery of swallowing ability at 6 months after stroke |  |  | 
| the occurrence of dysphagia - related medical complications at 6 months. |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Swallowing disorder, Stroke, Standardized swallowing therapy, Randomized controlled trial
Long-term Effects of Time to Treatment in Subarachnoid Haemorrhage

Study Overview
=================
Brief Summary
-----------------
For patients with spontaneous subarachnoid haemorrhage, it remains to be investigated if there is an association between the time from patients call the Emergence Medical Coordination Center to neurosurgical admission and long-term outcome. This is a retrospective cohort study with four-year followup. The primary aim is to determine if the time to neurosurgical admission is associated to labour marked affiliation and mortality after four years.

Official Title
-----------------
Time From First Health Care Contact to Neurosurgical Admission and the Effect on Long-term Labour Market Affiliation and Mortality in Patients With Spontaneous Subarachnoid Haemorrhage

Conditions
-----------------
Spontaneous Subarachnoid Hemorrhage

Intervention / Treatment
-----------------
* Other: Time


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Spontaneous subarachnoid haemorrhage registered in the Danish National Patient Register and confirmed by medical record review. Initially admitted to a hospital in the Capital Region of Denmark between 1 January 2008 and 31 December 2014. Exclusion Criteria: Prior subarachnoid haemorrhage. Inhospital symptom onset.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Confirmed spontaneous subarachnoid haemorrhage<br>Patients, minimum 18 years of age, identified with the diagnosis in the Danish National Patient Register. The diagnosis is verified by medical record review. All patients were initially admitted to a hospital in the Capital Region of Denmark. In a national labour marked register and the civil registration register the patients are then followed for four years. | Other: Time<br>* Exposure is the time from patients call the Emergency Medical Coordination Center to they are admitted to a neurosurgiocal department.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Labour marked affiliation and mortality | The incidence of all-cause death and early retirement over the four-years after sSAH for different times to treatment is shown with Kaplan-Meier plots, and assessed with log-rank tests. | 4 years |
Sedation and Ease of Weaning From Mechanical Ventilation

Study Overview
=================
Brief Summary
-----------------
Daily interruption of sedation is one of the modalities which is known to enhance early weaning and separation from mechanical ventilation . Daily sedation interruption is also known to help decreasing incidence of ventilator associated pneumonia. The new modality is no sedation.

Detailed Description
-----------------
there is an increase of incidence of chronic obstructive lung disease associated respiratory failure which necessitates invasive mechanical ventilation. It is well known that one of the bundles for enhanced recovery of such cases is the daily interruption of sedation . Recently studies have demonstrated the feasibility of just using sedation for initiation of mechanical ventilation, then utilization of no sedation technique as a more this offers less side effects .

Official Title
-----------------
Daily Interruption of Sedation Versus Non Sedation in Mechanically Ventilated Respiratory Failure Patients

Conditions
-----------------
Respiratory Failure, Midazolam Overdose, Chronic Obstructive Pulmonary Disease, Weaning Failure

Intervention / Treatment
-----------------
* Drug: Daily interruption of midazolam


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Obstructive lung disease Respiratory failure Invasive mechanical ventilation Exclusion Criteria: Neurological deficit Cognitive dysfunction Extensive malignancy septic Shock

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Daily interruption of sedation<br>Daily interruption of sedation will be done at 7 am daily by stoppage of midazolam infusion | Drug: Daily interruption of midazolam<br>* daily at 7 am midazolam infusion will be stopped spontaneous breath trial will be done<br>* Other names: sedation interruption;|
| No Intervention: No Sedation<br>No sedation will be given after initiation of mechanical ventilation | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| duration of mechanical ventilation | number of days of mechanical ventilation | first 30 days |
PPAR-gamma: a Novel Therapeutic Target for Asthma?

Study Overview
=================
Brief Summary
-----------------
To test the hypothesis that stimulation of PPAR-γ receptors has a therapeutic role in the treatment of asthma.

Official Title
-----------------
PPAR-gamma: a Novel Therapeutic Target in Asthma?

Conditions
-----------------
Asthma

Intervention / Treatment
-----------------
* Other: placebo
* Drug: IMP Pioglitozone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18-75 of either sex with a clinical diagnosis of asthma, FEV1 ≥ 60% predicted and an increase in FEV1 of greater than 12% following inhaled salbutamol 400μg or Peak Expiratory Flow (PEF) variability >12% during run-in. Allowed medication: 0-800μg inhaled beclomethasone diproprionate or equivalent and as required short acting beta agonist. Exclusion Criteria: Current smoking, > 10 pack years smoking history, Treatment with leukotriene antagonists, Liver or cardiovascular disease, Oral steroid treatment or exacerbation within 6 weeks, Females who are pregnant, lactating or not using adequate contraception, Any contra-indication to pioglitazone (hypersensitivity to pioglitazone, cardiac failure, history of cardiac failure, hepatic impairment, diabetic ketoacidosis), Oral or insulin treatment for diabetes, Treatment with gemfibrozil or rifampicin.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: IMP Pioglitazone<br>Pioglitazone 30mg daily by mouth for 4 weeks then 45mg daily for 8 weeks and placebo 30mg daily by mouth for 4 weeks then 45mg daily for 8 weeks. | Drug: IMP Pioglitozone<br>* Pioglitazone 30mg daily by mouth for 4 weeks then 45mg daily for 8 weeks and placebo 30mg daily by mouth for 4 weeks then 45mg daily for 8 weeks.<br>|
| Placebo Comparator: Placebo<br>Placebo 30mg daily by mouth for 4 weeks then 45mg daily for 8 weeks and placebo 30mg daily by mouth for 4 weeks then 45mg daily for 8 weeks. | Other: placebo<br>* placebo 30mg daily by mouth for 4 weeks then 45mg daily for 8 weeks<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| FEV1 after 12 weeks treatment |  | week 12 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in symptoms | Change over 12 weeks in daily asthma symptoms, mean morning and evening PEF, Juniper asthma control questionnaire and asthma quality of life questionnaire scores, exhaled nitric oxide level, bronchial hyper-responsiveness, induced sputum cell counts and analysis detailed above, adverse effects | 12 weeks |