Long Arm Vs Short Arm Fiberglass Cast for Treatment of Displaced Distal Radius Fractures

Study Overview
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Brief Summary
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The aim of the study is to determine by multicenter randomized controlled trial whether short arm fiberglass casts are as effective as long arm casts for immobilizing displaced pediatric distal third forearm fractures that have undergone closed reduction. The primary outcome is loss of reduction requiring cast wedging, recasting, repeat reduction, or surgical intervention. Secondary outcomes will include Patient Reported Outcome Measures for physical function, such as Pedi-FABS, PROMIS (Patient Reported Outcomes Measurement Information System) Upper Extremities , and UCLA (University of California Los Angelos) Activity Scale, and pain/comfort levels,such as PROMIS Pediatric Pain Interference, PROMIS Pediatric Pain Intensity, and VAS ( Visual Analogue Scale) comfort in cast. In addition, secondary outcomes include complications (skin irritation, compartment syndrome, elbow stiffness, cast saw burns etc). The investigators will assess potential risk factors for loss of reduction including initial displacement, level of fracture (physeal, metaphyseal, meta-diaphyseal), initial translation, initial angulation, age, sex, cast index, padding index, adequacy of initial reduction, and provider level of training.

Detailed Description
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The most common type of fracture in pediatric patients is the distal third forearm fracture, with over 600,000 cases in the in the United States each year. Traditionally long arm casts have been used for displaced distal forearm fractures, but it may be the case that short arm casts are sufficient. Three RCTs (Randomized Control Trials) have been performed comparing the efficacy of plaster short and long arm casts for displaced distal forearm fractures; these studies have shown no significant difference in angulation or displacement. If short and long arm casts offer comparable stability, the short arm version would likely be desirable as patient satisfaction and cost effectiveness are improved with short arm casts. Despite the results of three well-executed RCTs, it is still common practice for long arm casts to be applied for distal forearm fractures. Many surgeons continue to recommend that their residents apply long arm casts for all displaced forearm fractures, including distal third fractures. At NYP (New York Presbyterian) Cornell and NYP Queens, residents routinely apply long arm casts for all forearm fractures. Long arm casts are more likely to result in elbow stiffness, although this is often a temporary complication. Long arm casts also require more material and take longer to apply or remove, potentially leading to higher treatment costs. Additionally, when a longer cast is worn there is a larger distance where a cast burn could occur. Skin irritation, particularly at the cubital fossa, is likely more common with a long arm cast, and they are overall less comfortable, due to elbow restriction and a heavier weight. Short arm casts that are well molded to the arm's contours have been shown to control forearm supination and pronation. A low cast index has been shown to significantly increase the rate of fracture redisplacement. The cast index determines the quality of cast molding, and is measured by dividing the sagittal width of the cast by the coronal width. Substantial changes in cast angulation have been attributed to poor cast-molding and a low cast index. The results suggested that short arm casts when appropriately molded can be effective in treating fractures of the distal third of the forearm. If short arm casts are equivalent in providing stability for distal third forearm fractures, providers should be using them preferentially to avoid the potential complications of elbow stiffness, cast burn, skin irritation, and patient dissatisfaction. However, surgeons persist with using long arm casts. Rationale for the persistent use of long arm cast is believed to include anecdotal concerns of residents placing inadequate short arm casts, leading to an increased risk for translation or angulation requiring recasting. Previous RCTs, however, do not provide clear recommendations, merely demonstrating that treatment using short and long arm casts lead to similar outcomes. Additionally, these past RCTs have limitations. Previous studies were conducted with plaster casts and could not extend their findings to other casting material. Valving techniques were also not noted in these studies; it is unclear whether or not casts were bivalved, which is currently the standard of care in the United States. These previous studies also randomized patients to short or long arm cast prior to cast application. As a result, it is possible that when long arm casts were applied the portion of cast overlying the fracture site was not molded as carefully as for short arm casts. Previous studies commented on cast index, but it was not clear whether residents were trained in ideal cast application and molding prior to study initiation. Finally, the outcome measures used in previous studies were an arbitrary loss in angulation or translation, instead of a focus on whether the fracture slipped sufficiently to change the treatment required (need for cast wedging, repeat reduction and casting, or surgical intervention). The aim of the study is to determine by multicenter randomized controlled trial whether short arm fiberglass casts are as effective as long arm casts for immobilizing displaced pediatric distal third forearm fractures that have undergone closed reduction.

Official Title
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Long Arm Vs Short Arm Fiberglass Cast for Treatment of Displaced Distal Radius Fractures: A Multi-Center Randomized Control Trial

Conditions
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Distal Forearm Fractures

Intervention / Treatment
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* Procedure: Closed Reduction
* Other: Long Arm Fiberglass Cast
* Other: Short Arm Fiberglass Cast


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients 4-12 years of age Displaced distal third forearm fracture (physeal, metaphyseal, meta-diaphyseal) requiring closed reduction Displacement must be: For children 4-9: angulation >30 degrees and/or 100% translation on either AP (anteroposterior) or lateral view. For children 10-12: angulation > 15 degrees and/or >50% translation on either AP or lateral view Exclusion Criteria: Patients undergoing additional orthopedic procedures at the time closed reduction of distal arm fracture Patient with a presenting open fracture A known pathologic fracture Patient with a refracture through pre-existing fracture lines Patients with compartment syndrome or neuropathy

Ages Eligible for Study
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Minimum Age: 4 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Long Arm Fiberglass Cast<br>Conscious sedation will be provided to patient while the reduction is performed by a cast trained orthopedic resident using standard techniques under fluoroscopic guidance. The arm will be held by an assistant or finger traps in the absence thereof. The arm will not be suspended until after the manipulation is performed. A stockingette and webril will first be applied, after which the short arm fiberglass portion of the cast will be applied. After short arm casting has been appropriately placed, randomization group will be revealed. Casting will be extended to the shoulder joint if the patient is assigned to the long arm cast group. The mold will then be applied and cast construct will be bivalved and taped. | Procedure: Closed Reduction<br>* The primary goal of closed reduction is to maintain appropriate bony alignment and angulation to allow for appropriate healing.<br>Other: Long Arm Fiberglass Cast<br>* A stockingette and webril will first be applied, after which the short arm fiberglass portion of the cast will be applied. After short arm casting has been appropriately placed, randomization group will be revealed. Casting will be extended to the shoulder joint if the patient is assigned to the long arm cast group. The mold will then be applied and cast construct will be bivalved and taped.<br>|
| Experimental: Short Arm Fiberglass Cast<br>Conscious sedation will be provided to patient while the reduction is performed by a cast trained orthopedic resident using standard techniques under fluoroscopic guidance. The arm will be held by an assistant or finger traps in the absence thereof. The arm will not be suspended until after the manipulation is performed. A stockingette and webril will first be applied, after which the short arm fiberglass portion of the cast will be applied. After short arm casting has been appropriately placed, randomization group will be revealed. Casting will be complete at this point if the patient is assigned to the short arm cast group. The mold will then be applied and cast construct will be bivalved and taped. | Procedure: Closed Reduction<br>* The primary goal of closed reduction is to maintain appropriate bony alignment and angulation to allow for appropriate healing.<br>Other: Short Arm Fiberglass Cast<br>* A stockingette and webril will first be applied, after which the short arm fiberglass portion of the cast will be applied. After short arm casting has been appropriately placed, randomization group will be revealed. Casting will be complete at this point if the patient is assigned to the short arm cast group. The mold will then be applied and cast construct will be bivalved and taped.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patients requiring repeat intervention due to loss of alignment | Proportion of patients requiring repeat intervention (cast wedging, recasting, or surgical intervention) following short arm vs long arm cast application. | Up to 7 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain assessed by patient reported outcomes - Surveys | Patient Reported Outcome Measures for pain as assessed by PROMIS(Patient-Reported Outcomes Measurement Information System) Pediatric Pain Interference. Highest raw score is 32, lowest raw score is 0, it is interpreted by t-score. | 1 week +/- 5 days visit, 3 weeks +/- 1 week, 6 weeks +/- 1 week, 3 months +/- 2 weeks , 6 months +/- 4 weeks | 
| Pain assessed by patient reported outcomes - Surveys | Patient Reported Outcome Measures for pain as assessed by PROMIS (Patient-Reported Outcomes Measurement Information System) Pediatric Pain Intensity. Highest raw score is 32, lowest raw score is 0, it is interpreted by t-score. | 1 week +/- 5 days visit, 3 weeks +/- 1 week, 6 weeks +/- 1 week, 3 months +/- 2 weeks , 6 months +/- 4 weeks | 
| Comfort assessed by patient reported outcomes - Scale | Patient Reported Outcome Measures for pain as assessed by Visual Analog Scale (VAS) comfort in cast. VAS measures the amount of pain that a patient feels currently and ranges across a continuum from none to an extreme amount of pain. Higher values represent more pain/ worse outcome. | 1 week +/- 5 days visit, 3 weeks +/- 1 week, 6 weeks +/- 1 week, 3 months +/- 2 weeks , 6 months +/- 4 weeks | 
| Physical function assessed by patient reported outcomes - Surveys | Patient Reported Outcome Measures for pain as assessed by Pedi-FABS ( Pediatric Functional Activity Brief Scale). Scoring of the Hospital for Special Surgery PediatricFunctional Activity Brief Scale is performed by addingpoints from each question for total possible score range from1 to 30 points. For ''Running'', ''Cutting'', ''Decelerating'',''Pivoting'', ''Duration'', and ''Endurance'', each question is worth 0, 1, 2, 3, or 4 points. Higher values mean that the child is more active. | 1 week +/- 5 days visit, 3 weeks +/- 1 week, 6 weeks +/- 1 week, 3 months +/- 2 weeks , 6 months +/- 4 weeks | 
| Physical function assessed by patient reported outcomes - Surveys | Patient Reported Outcome Measures for pain as assessed by PROMIS ( Patient-Reported Outcomes Measurement Information System) Upper Extremity. Within the Pediatric Upper Extremity short form, there are two items (3880R2 and 3881R1) with collapsed response categories. These items have response options scored as 3=With no trouble, 2=With a little trouble, 1=With some trouble, 0=With a lot of trouble, 0=Not able to do. | 1 week +/- 5 days visit, 3 weeks +/- 1 week, 6 weeks +/- 1 week, 3 months +/- 2 weeks , 6 months +/- 4 weeks | 
| Physical function assessed by patient reported outcomes - Surveys | Patient Reported Outcome Measures for pain as assessed by UCLA Activity Scale (University of California, Los Angeles Activity Scale). 1 is the lowest raw score, and 10 is the highest raw score. 1= 1: Wholly Inactive, dependent on others, and can not leave residence and 10= 10: Regularly participates in impact sports. | 1 week +/- 5 days visit, 3 weeks +/- 1 week, 6 weeks +/- 1 week, 3 months +/- 2 weeks , 6 months +/- 4 weeks | 
| Number of Participants with complications | irritation, compartment syndrome, elbow stiffness, cast saw burns etc | 1 week +/- 5 days visit, 3 weeks +/- 1 week, 6 weeks +/- 1 week, 3 months +/- 2 weeks , 6 months +/- 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Displaced distal third forearm, Pediatric Patients, Closed reduction, Cast, Patient centered outcome data, RCT