Efficacy Analysis of Complete Laparoscopic Resection of Recurrent Hepatocellular Carcinoma

Study Overview
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Brief Summary
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This study is aiming to evaluate the clinical efficacy of complete laparoscopic resection of recurrent hepatocellular carcinoma (HCC).

Detailed Description
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The investigators conducted a prospective study of 64 patients who were diagnosed with recurrent HCC and underwent surgical resection at the Sun Yat-sen University Cancer Center from June 2014 to November 2014; 31 patients were enrolled in the laparoscopic group and underwent complete laparoscopic resection of HCC, and 33 patients were enrolled in the control group and underwent open surgical resection. The operation time, intraoperative blood loss, shortest distance between the tumor edge and normal liver tissue, postoperative pain scores, postoperative time until the patient could walk, postoperative time until the patient could pass gas, hospital stay, and inpatient costs were compared between the two groups. The patients were followed up for one year after surgery, and the relapse-free survival was compared between the two groups.

Official Title
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Efficacy Analysis of Complete Laparoscopic Resection of Recurrent Hepatocellular Carcinoma

Conditions
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Recurrent Hepatocellular Carcinoma

Intervention / Treatment
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* Procedure: laparoscopic resection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: recurrent HCC after open surgery recurrent HCC located in any part of the left lateral lobe or the diaphragm side of the right lobe and near the surface of the liver, which resulted in an easier operation no significant surgical contraindications no major vessel or bile duct tumor invasion and metastasis grade A or B liver function or grade C liver function that recovered to grade A after liver-protective treatment; the patient and his/her family was willing to undergo laparoscopic resection. Exclusion Criteria: major vessel or bile duct tumor invasion recurrent HCC located in the right liver parenchyma and near secondary vessels and bile ducts, resulting in a difficult operation grade C liver function significant surgical contraindications the patient and his/her family declined laparoscopic hepatectomy.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| laparoscopic group<br>patients in the laparoscopic group underwent laparoscopic resection of recurrent HCC | Procedure: laparoscopic resection<br>* The surgical instruments used for the laparoscopic group included conventional laparoscopic instruments (three 5 mm trocars, two 10 mm trocars, and two damage-free laparoscopic clamps), the STORZ high-resolution laparoscopic operating system (Germany), the GEN300 ultrasonic scalpel system (Johnson & Johnson, USA), a laparoscopic linear cutter stapler (Johnson & Johnson, USA), a laparoscopic ultrasound device, LigaSure, bipolar coagulation, titanium laparoscopic clips, and absorbable hemostatic gauze.<br>|
| control group<br>patients in the control group underwent conventional open surgery | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Perioperative complications | The operation time, intraoperative blood loss, shortest distance between the tumor edge and normal liver tissue, postoperative pain scores, postoperative time until the patient could walk, postoperative time until the patient could pass gas, hospital stay, and inpatient costs were compared between the two groups. | within the first 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| relapse-free survival | The patients were followed up for one year after surgery, and the relapse-free survival was compared between the two groups. | 1 year after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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laparoscopic, hepatocellular carcinoma, recurrence