Effects of Repeated Short-term Microgravity During Parabolic Flight Conditions on Neuro-endocrine, Immune and Metabolic Changes

Study Overview
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Brief Summary
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From previous parabolic flight campaigns completed by our research group investigators gathered data showing important changes in neuro-endocrine and also immunological changes. This experiment now will complete the data set-up obtained during the MARS500 study on how these respective individuals will re-act to highly physically and emotionally challenging situations during a parabolic flight. This add-on experiment to MARS500 will enable answering to the following questions i) if the stress response systems - when compared for two conditions but in the same individuals - do react uniformly and ii) if those subjects prone to have adequate stress response pattern will show gradually less immune modulation effects. The understanding of the complex interactions of stress and immunity under chronic and acute stress conditions might help to enable adequate health and immune monitoring and might as well suggest suitable countermeasures for the prevention of the unwanted immunological effects during long-term confinement and space missions.

Conditions
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Healthy

Intervention / Treatment
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* Other: Parabolic flight
* Other: neuro-endocrine measurements
* Other: immunological measurements
* Other: cellular energy metabolism measurements


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy volunteers (men or women) Aged from 18 to 65 Affiliated to a Social Security system and, for non-French resident, holding a European Health Insurance Card (EHIC) Who accepted to take part in the study Who have given their written stated consent Who participated in the MARS500 experiment Who has passed a medical examination similar to a standard aviation medical examination for private pilot aptitude. There will be no additional test performed for subject selection. Exclusion Criteria: Person who took part in a previous biomedical research protocol, of which exclusion period is not terminated Pregnant women

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Stress response measurements<br> | Other: Parabolic flight<br> <br> Other: neuro-endocrine measurements<br>* psychic stress tests, stress hormones: prolactin, cortisol, endo-cannabinoids<br>Other: immunological measurements<br>* blood cell counts, B2 integrins, cytokines, C-reactive protein<br>Other: cellular energy metabolism measurements<br>* purines, lactate<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| neuro-endocrine measurements composite | prolactin, cortisol, endo-cannabinoids | baseline | 
| immunological measurements composite | blood cell counts, B2 integrins, cytokines, C-reactive protein | baseline | 
| cellular energy metabolism measurements composite | purines, lactate | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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volunteers