Long-term Follow-up of Living Liver Donors: A Single-center Experience

Study Overview
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Brief Summary
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Data on the long-term consequences of living liver donation are scarce. This study examined clinical, laboratory, and radiological parameters and long-term health-related quality of life (HRQoL) in 237 living liver donors and 239 matched controls during 48 to 168 months of postdonation follow-up.

Detailed Description
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Data on the long-term consequences of living liver donation are scarce. This study examined clinical, laboratory, and radiological parameters and long-term health-related quality of life (HRQoL) in 237 living liver donors and 239 matched controls during 48 to 168 months of postdonation follow-up. We used the 36-item short-form health survey (short form-36 health survey, version 1 [SF-36]). The scores for the 4 following subscales were higher in nondonors than in donors: physical functioning (P = 0.009), role limitations due to physical health (P = 0.002), energy/fatigue (P < 0.001), and bodily pain (P < 0.001). The scores on the 8 subscales of the SF-36 were higher in donors with living recipients than in donors whose recipients died (P < 0.001). Our results suggest that living donor right hepatectomy is safe and results in a postdonation HRQoL similar to that of nondonors in those donors whose recipients are healthy, while donors whose recipients die have a lower HRQoL that is significantly negatively correlated with the time since recipient death and improves over time.

Official Title
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Long-term Follow-up of Living Liver Donors: A Single-center Experience

Conditions
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Liver Transplantation

Intervention / Treatment
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* Other: health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]).


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age 18-50 years no comorbidities. BMI less than 30 kg/m2. compatible ABO group. Exclusion Criteria: Older than 50 years. Associated comorbidities. Obesity. Noncompatible ABO group.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| living liver donors<br>cases already underwent hepatectomy for living-donor liver transplantation. | Other: health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]).<br>* health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]).<br>|
| matched controls<br>healthy persons who attended the preoperative clinic while preparing for donation but were rejected because of an ABO blood group mismatch. | Other: health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]).<br>* health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| health-related quality of life (HRQoL) | health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]). | 4 to 16 years of follow up | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Quality of life, Living-donor liver transplantation, Follow up