Transcranial Magnetic Stimulation Treatment of Hoarding Disorder

Study Overview
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Brief Summary
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This is multiple baseline study including up to three participants with a primary diagnosis of hoarding disorder. All patients will receive unblinded repetitive transcranial magnetic stimulation study intervention.

Detailed Description
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Study assessments will be conducted at pre-baseline, weekly during baseline assessment (until a stable baseline is established, but not less than 2, 4, and 6 weeks for patients respectively), weekly during treatment, and at post-treatment. Magnetic resonance imaging (MRI) will be competed at pre-baseline, pre-treatment, and post-treatment. Treatment will entail daily (5 days/week) sessions of repetitive transcranial magnetic stimulation using the Neurostar Therapy System for 6 weeks employing right-sided, low frequency stimulation (1 Hz, 900 pulses/session for 30 sessions, 27,000 total pulses, intensity at 90% of the passive motor threshold) to the dorsolateral prefrontal cortex (DLPFC). Neuronavigation will direct coil placement over the DLPFC based upon structural MRI.

Official Title
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Transcranial Magnetic Stimulation Treatment of Hoarding Disorder

Conditions
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Hoarding

Intervention / Treatment
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* Device: Neurostar Transcranial Magnetic Stimulation Therapy System


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed with hoarding disorder as primary disorder Clinical Global Impression Score > 3 Saving Inventory-Revised score > 39 Exclusion Criteria: Any contraindication for participation in magnetic resonance imaging or transcranial magnetic stimulation Severe and/or unstable medical or psychiatric condition that require immediate medical attention Diagnosed with current major depressive episode Currently taking psychiatric medication

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: rTMS Treatment<br>NeuroStar Transcranial Magnetic Stimulation Therapy System | Device: Neurostar Transcranial Magnetic Stimulation Therapy System<br>* Treatment will entail daily (5 days/week) sessions of repetitive transcranial magnetic stimulation for 6 weeks employing right-sided, low frequency stimulation (1 Hz, 900 pulses/session for 30 sessions, 27,000 total pulses, intensity at 90% of the passive motor threshold) to the dorsolateral prefrontal cortex (DLPFC).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Saving Inventory-Revised (SI-R) Total Score | The Saving Inventory-Revised (SI-R) is a self-report measure which includes 23 items assessing the severity of hoarding symptoms including difficulty discarding, acquiring, and clutter. The 23 items are added for a total score which ranges from 0 to 92 and with higher score indicating more severe hoarding symptoms. | Pre-baseline, Post-baseline/Pre-treatment, Post-treatment, 2-Month Follow-up |