Ultrasonic Cardiogram Evaluate the Prognosis of Percutaneous Revascularization of Chronic Total Occlusions

Study Overview
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Brief Summary
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Chronic total occlusions (CTO) are encountered in almost one-fourth of patients undergoing coronary angiography. The presence of an untreated CTO has been related to adverse clinical prognosis, both in stable angina and acute myocardial infarction, and is often associated with persistent symptomatic angina. Depending on their symptomatic and functional status as well as anatomical complexity, CTO can be treated by optimal medical therapy only or therapy combined with coronary revascularization. This study designed to evaluate the safety and efficacy of coronary chronic total occlusion PCI by ultrasonic cardiogram.

Detailed Description
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UCEPPCIOCT maintains a prospective clinical registry of all individual who undergo cardiac angiography,PCI or optimistic medicine treatment. 1. research objective to observe the changes of cardiac function postoperative PCI in patients with CTO and the incidence of major adverse cardiovascular events, and provide the reality basis for PCI strategy in clinical patients with CTO . 2. research content: follow up the patients with CTO by using echocardiography in preoperative and postoperative PCI in 1m, 3ms, 6ms, 12ms to assess the changes of cardiac structure and cardiac function. 2, comparison the 'incidence of major adverse cardiovascular events undergo PCI treatment in success and failure group in patients with CTO (such as severe angina attack, severe acute coronary syndrome, severe heart failure should be rehospitalized , fatal arrhythmia and sudden cardiac death, etc.)

Official Title
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Ultrasonic Cardiogram to Evaluate the Long-term Outcome and Prognosis of Coronary Artery Chronic Total Occlusions for Percutaneous Revascularization Versus Optimal Medical Treatment

Conditions
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Coronary Chronic Total Occlusion

Intervention / Treatment
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* Device: stent


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: coronary artery of chronic total occlusion Exclusion Criteria: ACS in 3months; once PCI or CABG; AF

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Sequential Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: recanalisation CTO lesion successful<br>Patients with CTO lesion performed PCI strategy and successfully recanalisation the CTO lesion with implanted stents . | Device: stent<br>* PTCA or PCI<br>* Other names: Balloon;|
| No Intervention: recanalisation CTO lesion failure<br>Patients with CTO lesion performed PCI strategy and failure recanalisation the CTO lesion with PCI wire and balloon.. | |
| No Intervention: OMT<br>Patients with CTO lesion optimal medicine treatment without PCI | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cardiac death, | patients with CTO postoperative sudden death cause for acute myocardial infarction or severe arrhythmia | postoperation 1year | 
| MACE | recurrent severe angina, revascularization | postoperation 1year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ultrasonic, chronic total occlusion, heart function