Use of Normal Saline With or Without Dextrose During Induction of Labor in Nulliparous

Study Overview
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Brief Summary
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The objective of this study is to compare the effects of use of normal saline (250 cc / h), with or without dextrose supplement, on the evolution of labor in nulliparous.

Detailed Description
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There is some controversy regarding intravenous hydration of patients during labor. While the use of a fast flow of hydration appears to be recognized beneficial, the addition of glucose is less well accepted. However studies on exercise physiology clearly demonstrates improved performance of skeletal muscle by increased hydration and carbohydrate replacement during prolonged exercise. This situation is similar to the condition of the uterus in labor especially since it is now established that glucose represents its principal source of energy. However, the effect of an additional carbohydrate intake on the evolution of labor has not been extensively studied until now, and there are several schools of thought on this subject. While some studies show that such glucose addition could reduce the total duration of labor as well as its second stage, others claim that this glucose supplement offers no benefit and may even be harmful to the fetus. It therefore seems imperative to conduct a study to compare the use of hydration with normal saline with or without dextrose during labor, as recommended in current flow (250 cc / h). To our knowledge, this has never been done.

Official Title
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Utilisation parentérale de Normal Salin Avec ou Sans Dextrose Durant l'Induction du Travail Chez Les Nullipares

Conditions
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Delivery Uterine

Intervention / Treatment
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* Other: 5% dextrose
* Other: normal saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: nulliparous woman monofetal pregnancy delivery at term elective induction favorable cervix (Bishop score of at least 6) cephalic presentation Exclusion Criteria: diabetes preeclampsia maternal heart disease

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: control<br>normal saline, 250 ml/h, until expulsion of placental | Other: normal saline<br>* women with an elective induction of labor receive IV hydratation (250 ml/h) with a normal saline solution<br>|
| Experimental: intervention<br>normal saline + 5% dextrose, 250 ml/h, until expulsion of placental | Other: 5% dextrose<br>* women with an elective induction of labor receive IV hydratation (250 ml/h) with a normal saline solution + 5% dextrose<br>Other: normal saline<br>* women with an elective induction of labor receive IV hydratation (250 ml/h) with a normal saline solution<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 2nd stage of labor |  | during delivery of a first baby, for an average of 5 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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induction of labor