Urinary and Anorectal Functional Disorders and Their Impact on CF Adults (PerineoMucoRMO)

Study Overview
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Brief Summary
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This observational study evaluates prevalence of functional perinea disorders (stress urinary incontinence, overactive bladder syndrome, dysuria, anal incontinence) on CF adults patients of the North-West CF Network. Its aims are to measure the severity of urinary and anorectal symptoms ; assess their impact on patients' quality of life, sexuality, care and social life and relationships ; identify the medical and demographic factors associated with the severity of urinary and anorectal disorders and their impact and determine the relationship between the severity of these disorders, various repercussions, and risk factors.

Detailed Description
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Urine and/or anal leakage are more frequent and troublesome for CF patients: leaks occur during efforts or laugh like in other people, but also when coughing or sneezing, which are amplified during periods of exacerbation and with the degradation of the pulmonary condition. In addition, fear of leakage can disrupt medical care: discomfort during physiotherapy, pulmonary function test. Urinary and anorectal functional disorders are therefore not only a factor degrading the quality of life but also a risk factor for worsening bronchial obstruction, patients limiting their cough and / or their care to avoid episodes of leakage. Given the lack literature data, investigators wanted to explore these areas. Validated and specific questionnaires will be self and anonymously administered to adult patients (n=175). The time requested to fill the forms is estimated to 1H. Questionnaires about sexual health are optional. Prospects considered, depending on the results, are: Extension to the adolescent population (14 and over); National extension; Systematic proposal of a screening and an appropriate management of pelvic floor functional disorders, depending on influent characteristics (age, gender ...): multidisciplinary working group to develop guidelines and specific tools for professional training and / or patient education; Implementation of a comparative study of interventions.

Official Title
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Assessment of the Prevalence and Severity of Urinary and Ano-rectal Functional Disorders and Their Impact on Quality of Life and Sexuality on CF Adults of the North-West CF Network

Conditions
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Cystic Fibrosis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women 18 years and over Cystic fibrosis confirmed by sweat test or genetic Followed in an adult or mixed CF Center of the French North-West CF Network Not transplanted and not entered on the waiting list for transplantation In a stable condition for at least 4 weeks Able to understand and respect the protocol and its requirements Who signed the consent prior to any other procedure protocol Exclusion Criteria: Major patients under guardianship / curatorship Patients seen in emergency situation Pregnant patients Dialysis patients Patients with urolithiasis Patients with severe exacerbation at the time of inclusion Patients on intravenous antibiotics within 4 weeks prior to inclusion Patient with an urinary tract infection (evaluation by dipstick at the time of inclusion

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Urinary Symptom Profile (USP) score | Assesses lower urinary tract symptoms (stress urinary incontinence, overactive bladder syndrome and dysuria) | at time of inclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Wexner Fecal Incontinence Scale | Assesses anal incontinence and its impact on quality of life | at time of inclusion | 
| SF-Qualiveen questionnaire | Assesses impact of urinary disorders on quality of life | at time of inclusion | 
| Cystic Fibrosis Questionnaire-Revised (CFQ-R) | Assesses quality of live related to cystic fibrosis | at time of inclusion | 
| International Index of Erectile Function (IIEF5) questionnaire | Assesses male sexual dysfunction | at time of inclusion | 
| Female Sexual Function Index (FSFI) | Assesses female sexual dysfunction | at time of inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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urinary incontinence, anal incontinence, sexuality, quality of life