Uterine Rupture International Data Acquisition

Study Overview
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Brief Summary
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Uterine rupture represents an uncommon event: it is is a life-threatening obstetric complication with high maternal and perinatal morbidity and mortality. Indeed, uterine rupture may cause catastrophic maternal and fetal complications (uterine hemorrhage, hysterectomy with consequent fertility loss, maternal and fetal death or cerebral palsy) which are hardly acceptable within the context of a natural event such as birth. Uterine rupture can occur during pregnancy, early in labor or following a prolonged labor, most frequently near or at term and, rarely, during early to mid-pregnancy. Its prevalence ranges between 0.006% for women without previous cesarean section (CS) in the western countries, to 25% for women with obstructed labor in African countries. Pregnancy after myomectomy or CS, vaginal delivery after cesarean sections (VBACs) and vaginal delivery after myomectomy are potentially at risk of uterine rupture. Despite uterine rupture is widely considered a life-threatening condition, so far most of published data refer to case reports or very small case series. In this scenario, the Uterine Rupture International Data Acquisition study group would like to collect a large number of events, in order to identify the potential risk factors among different populations through a multivariate analysis.

Official Title
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Uterine Rupture in Pregnancy: the URIDA (Uterine Rupture International Data Acquisition) Study

Conditions
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Uterine Rupture Gravid

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Women with uterine rupture occurred during pregnancy. Exclusion Criteria: None.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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Female

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Uterine rupture<br>Women with uterine rupture occurred during pregnancy. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Uterine rupture | Women with uterine rupture occurred during pregnancy. | A retrospective analysis of 10 years. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gestational age at uterine rupture | Gestational age, calculated as weeks and days, in which uterine rupture occurred. | A retrospective analysis of 10 years. | 
| Parity | The number of previous delivery. | A retrospective analysis of 10 years. | 
| Body Mass Index | The Body Mass Index of each patient in which uterine rupture occurred. | A retrospective analysis of 10 years. | 
| Presence of myomas | The occurrence of myomas in each patient in which uterine rupture occurred. | A retrospective analysis of 10 years. | 
| Hysterectomy | The number of cases in which it was necessary to perform hysterectomy after uterine rupture. | A retrospective analysis of 10 years. | 
| Hospital stay | The hospital stay from the admission to the discharge, expressed in days. | A retrospective analysis of 10 years. | 
| Neonatal complications | The occurrence of neonatal complications, included neonatal deaths. | A retrospective analysis of 10 years. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Uterine rupture, Cesarean section, Labour, Myomectomy, Delivery