The Effects of Dexmedetomidine on cTnI and GP-BB in Patients Undergoing OPCABG

Study Overview
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Brief Summary
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The purpose of this study is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients undergoing off-pump coronary artery bypass Grafting.

Detailed Description
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Dexmedetomidine is a highly selective α2-adrenoceptor agonist used as a sedative or adjuvant anesthetic drug in clinical settings.From clinical observation, dexmedetomidine has been revealed to reduce the incidence of cardiovascular adverse events in patients with heart diseases during non-cardiac surgeries.Therefore, the aim of this sudy is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients during cardiac surgeries.

Official Title
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The Effects of Dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in Patients Undergoing Off-pump Coronary Artery Bypass Grafting

Conditions
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Coronary Artery Bypass, Off-Pump

Intervention / Treatment
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* Drug: dexmedetomidine
* Other: normal saline


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients undergoing off - pump coronary artery bypass grafting ASA physical status III-IV Aged 40-70 years NYHA physical status II-III Exclusion Criteria: Bradycardia Atrioventricular block Echocardiography suggested:LVEF <40%, LVED>65mm Allergic to the drugs

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group dexmedetomidine<br>20 eligible patients are received 0.5ug/kg dexmedetomidine intravenously 15 minutes before surgery | Drug: dexmedetomidine<br>* receive dexmedetomidine 0.5 μg/kg<br>* Other names: Dex;|
| Placebo Comparator: Group control<br>20 eligible patients are received equal volumes normal saline intravenously 15 minutes before surgery | Other: normal saline<br>* receive equal volume of normal saline<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of cardiac troponin I at preoperative, postoperative，and 24 hours after surgery. | Blood samples were sampled at preoperative, postoperative，and 24 hours after surgery for the cTnI，which were analyzed by using enzyme linked immunosorbent assay (ELISA). | At preoperative, postoperative，and 24 hours after surgery. | 
| Change of Glycogen Phosphorylase Isoenzyme BB at preoperative, postoperative，and 24 hours after surgery. | Blood samples were sampled at preoperative, postoperative，and 24 hours after surgery for the GP-BB，which were analyzed by using enzyme linked immunosorbent assay (ELISA). | At preoperative, postoperative，and 24 hours after surgery. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dexmedetomidine, Cardiac Troponin I, Glycogen Phosphorylase Isoenzyme BB