Cardiac Function in Severe Aneurysmal Subarachnoid Haemorrhage Patients

Study Overview
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Brief Summary
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Cardiac dysfunction can occur in aneurysmal subarachnoid haemorrhage and might impact patient's neurologic outcome Condition Aneurysmal subarachnoid haemorrhage World Neurosurgeon Federation Score ≥ III

Detailed Description
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Trans-thoracic echocardiography on day 1, day 3 and day 7 Speckle-Tracking of echocardiographic loops by a cardiologist blinded to the patient's management and outcome

Official Title
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Speckle Tracking Assessment of Cardiac Function in Severe Aneurysmal Subarachnoid Haemorrhage and Impact on Neurologic Outcome (SPLASH)

Conditions
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Aneurysmal Subarachnoid Haemorrhage, World Neurosurgeon Federation Score ≥ III

Intervention / Treatment
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* Procedure: Echocardiography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Aneurysmal subarachnoid haemorrhage World Neurosurgeon Federation Score ≥ III Written information to next-of-kin and patients when possible Exclusion Criteria: History of myocardial infarction, chronic heart failure with NYHA ≥ 2, major heart surgery Lack of acoustic window to perform trans-thoracic echocardiography

Ages Eligible for Study
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Minimum Age: 15 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Aneurysmal subarachnoid haemorrhage<br>Speckle-tracking images in Echocardiography | Procedure: Echocardiography<br>* Speckle-Tracking of echocardiographic loops by a cardiologist blinded to the patient's management and outcome<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neurologic outcome | modified Rankin Scale (mRS). Poor neurological outcome was considered as death or severe disability (mRS 5-6). | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between cardiac strain on day 1 and Left Ventricular Ejection fraction |  | Day 1 | 
| Correlation between cardiac enzymes (NT-proBNP, troponin T US) and cardiac strain |  | Day 1 | 
| Correlation between EKG findings and cardiac strain |  | Day 1 | 
| Time to amines discontinuation |  | During Intensive Care Unit stay, expected average 17 days | 
| Duration of mechanical ventilation |  | Duration of mechanical ventilation, expected average 15 days | 
| Length of ICU stay |  | Duration of ICU stay, expected average 17 days | 
| Correlation between Cardiac function and Mechanical Ventilation |  | Day1, day3, day7 and extubation time expected average 15 days | 
| Correlation between Cardiac function and ICU length of stay |  | Day1, day3, day 7 and end of stay in ICU expected average 17 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Aneurysmal subarachnoid haemorrhage