Meal Stimulating After Roux-en Y Gastric Bypass

Study Overview
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Brief Summary
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In many studies, gastric bypass surgery led to total remission of type 2 diabetes (T2DM) as early as 1 - 2 days after surgery before any real weight loss has occurred. This suggests that the remission of the T2DM is due to the direct effect of the operation, more than the secondary effect of the weight loss. The reasons for the major effect on the glucose metabolism after gastric bypass surgery are still unaccounted for. The aim of this project will be to unveil some of the mechanisms that explain the effect of gastric bypass surgery on the glucose metabolism. Further more to find a better way of testing patients that have just undergone gastric bypass surgery. It is not possible to test patients who have just undergone gastric bypass surgery with normal oral glucose tolerance test (OGTT) and a normal meal, because patients can only take in fluid and a normal OGTT will often lead to dumping. Instead we will try to modify these tests - OGTT with lower glucose level and meal-testing with a protein drink. The hypothesis of the study is that the investigators can see changes in different hormones and adipokines before and after surgery, even with modified OGTT and meal testing. The project will consist of clinical trials on patients without T2DM that will undergo gastric bypass surgery. The studies will take place before and within the first week after surgery. The investigators will measure different hormones and adipokines after OGTT and a meal with a protein drink. The investigators expect to see significant changes in some of the analyses after the operation in patients undergoing gastric bypass.

Official Title
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Meal Stimulating After Roux-en Y Gastric Bypass

Conditions
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Gastric Bypass, Obesity

Intervention / Treatment
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* Procedure: gastric bypass surgery and testing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Obese with BMI> 40 undergoing gastric bypass surgery OR Obese with BMI > 35 with complications of their obesity in form of high blood pressure or other related complications undergoing gastric bypass surgery Age between 20-60 years Exclusion Criteria: Age > 60 Diabetes Psychiatric illness Mentally challenged Addiction Serious cardiac or lung diseases Diseases in the abdomen Other serious illness

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients without diabetes undergoing gastric bypass<br> | Procedure: gastric bypass surgery and testing<br>* The patients will be tested with OGTT and meal testing before and after undergoing gastric bypass surgery.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Meal-test, reduced OGTT, gastric bypass surgery and glucose metabolism, Glucose metabolism before and after gastric bypass, Different OGTT, New meal- test