Graft Patency in Beating Heart Vs. Conventional CABG Using Cardiac CT

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare graft patency rates following coronary artery bypass graft surgery performed by beating heart vs. conventional techniques using cardiac CT scanning to evaluate the bypass grafts.

Detailed Description
-----------------
The issue of whether to perform conventional CABG or off-pump CABG continues to be the subject of debate. Controversy remains regarding the appropriateness of applying OPCAB to all patients as opposed to selected sub-populations. The main strategy of CABG is to obtain complete revascularization with the least morbidity and highest long-term patency rates. Current medical literature is conflicted regarding graft patency rates in OPCAB vs. conventional CABG. Data is also limited due to patient refusal for conventional angiography to assess grafts following surgery. Cardiac computed tomography (CT) offers a non-invasive method to assess graft patency that is 100% accurate for the diagnosis of graft patency vs. occlusion. This study is a prospective randomized controlled trial evaluating graft patency in on-pump vs. off-pump CABG using cardiac CT scanning. The study hypothesis is that graft patency rates will be equivalent between the two techniques.

Official Title
-----------------
Graft Patency Following Off-Pump CABG Vs. On-Pump CABG Using 64 MDCT Bypass Graft CT Angiography

Conditions
-----------------
Coronary Artery Disease Amenable to Bypass Graft Surgery

Intervention / Treatment
-----------------
* Procedure: Off-Pump Coronary Artery Bypass Graft Surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Surgery indicated Patient is hemodynamically stable Isolated coronary artery surgery (no valve) No contraindications to cardiopulmonary bypass No previous surgery (not redo CABG) Exclusion Criteria: critically ill patient with hemodynamic instability. concomitant cardiac procedures. inability to provide written informed consent. prior severe reaction to contrast dye : life-threatening anaphylactoid reactions cardiac dysrhythmias and arrest cardiovascular and pulmonary collapse elevated serum creatinine (>150 mmol/L). contraindications to cardiopulmonary bypass. Age < 18 years .

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Off-Pump Coronary Artery Bypass Graft Surgery|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Graft patency as determined by bypass graft CT angiography at 3 months and 12 months following surgery |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of Hospital Stay |  |  | 
| Blood Loss |  |  | 
| Operative Time |  |  | 
| Post-op Complications |  |  | 
| Quality of Life Assessment |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Coronary Artery Disease, Coronary Artery Bypass Graft Surgery, Off-pump CABG, Cardiac CT, Bypass Graft CT angiography