Prompt Human Coronary Collateral Vasomotor Function Induced by Dynamic Physical Exercise

Study Overview
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Brief Summary
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The purpose of this study in humans with stable coronary artery disease (CAD) treatable by PCI (percutaneous coronary intervention) is to evaluate if dynamic physical exercise leads to an instantaneous improvement of coronary collateral function.

Detailed Description
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The existence of coronary collateral vessels and their benefit against cardiac events have been recognized for many years, but their functional capacity in response to physical exercise has partially remained elusive. Via endothelial shear stress, the fundamental stimulus for collateral development, exercise theoretically leads to collateral vasodilation and recruitment by an increase in heart rate and blood pressure during exercise. Moreover, the phenomenon of walking through angina indicates that collateral function and physical activity are related and their interaction is of clinical relevance. The purpose of the present study in humans with stable coronary artery disease was to assess the instantaneous response of coronary collateral function to dynamic physical exercise.

Official Title
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Prompt Human Coronary Collateral Vasomotor Function Induced by Dynamic Physical Exercise

Conditions
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Coronary Artery Disease

Intervention / Treatment
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* Other: dynamic physical exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age more than or 18 years old 1- to 3-vessel coronary artery disease (CAD) Stable angina pectoris At least 1 stenotic lesion suitable for PCI Negative Allen-test Written informed consent to participate in the study Exclusion Criteria: Patients admitted as emergencies Acute myocardial infarction Unstable CAD Q-wave myocardial infarction in the area undergoing CFI measurement CAD treated best by CABG Severe valve disease Pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: rest first<br>rest first, cfi, exercise, cfi | Other: dynamic physical exercise<br>* dynamic supine bicycle exercise for 6 minutes<br>* Other names: ex first;|
| Active Comparator: exercise first<br>ex first | Other: dynamic physical exercise<br>* dynamic supine bicycle exercise for 6 minutes<br>* Other names: ex first;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of collateral flow index (CFI, no unit) during exercise (E) compared to CFI at rest (R). |  | 6 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation of collateral flow index change and maximal workload. |  | 6 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CAD, prompt physical exercise, collateral function