Radiofrequency-assisted Liver Resection in Intractable Liver Cancer

Study Overview
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Brief Summary
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In this retrospective study, the investigators assessed the application of radiofrequency-assisted liver resection in intractable liver cancer resection, and plan to analysis the different factors.

Detailed Description
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The primary clinical treatment of liver cancer is surgical resection, although many integrated applications develop rapidly, surgery is still the best way to remove the tumour lesion. Traditional ways that have curative removed tumours in three methods, which are liver resection, liver transplantation and radiofrequency ablation (RFA). As for primary liver cancer, surgery, and RFA are both effective and safety, but for the complexity of end-stage liver cancer, surgical resection may not remove the tumours alone. Surgical resection with radiofrequency ablation therapy for intractable liver cancer is a kind of active plan. The therapy can eliminate the tumour, maximize the protection of patient liver tissue, reduce operation damage, reduce the incidence of complications, and improve patients quality of life after surgery.

Official Title
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The Application of Radiofrequency-assisted Liver Resection in Intractable Liver Cancer

Conditions
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Liver Cancer

Intervention / Treatment
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* Procedure: radiofrequency
* Procedure: TACE
* Procedure: TACE+radiofrequency


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Ultrasound-guided fine-needle aspiration pathology or postoperative pathology was confirmed to be liver cancer, no pathological results according to China 's 2017 version of the hepatocarcinoma (HCC) diagnosis and treatment specifications, in line with the standard clinical diagnosis of liver cancer According to Barcelona Clinic Liver Cancer (BCLC) staging criteria, it is stage C (stage C: single tumour> 5 cm or more than three tumours, and at least one tumour> 3 cm, liver function Child-Pugh A or B, with lymph node metastasis or distant metastasis or portal vein or Venous liver trunk is invaded, penance Status (PST) score 1-2 points) Exclusion Criteria: HCC patients with other malignant tumours Metastatic liver tumour Patients with liver abscess Patients with organ dysfunction

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| radiofrequency-assisted liver resection<br>radiofrequency-assisted liver resection for intractable liver cancer | Procedure: radiofrequency<br>* radiofrequency combined with liver resection<br>|
| TACE(transcatheter arterial chemoembolization)<br>temporary TACE for intractable liver cancer | Procedure: TACE<br>* only TACE treatment<br>|
| radiofrequency ablation plus TACE<br>radiofrequency ablation plus TACE for intractable liver cancer | Procedure: TACE+radiofrequency<br>* TACE followed by radiofrequency<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The survival rates for one-year to five-year | The survival rates was defined as the percentage of liver cancer for five years. | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The hospital stay | The length of stay in a hospital regarding days | 3 months | 
| The Child-Pugh score after therapy | The Child-Pugh is based on the presence and severity of ascites and hepatic encephalopathy, the prolongation of prothrombin time, and the levels of serum bilirubin and albumin. According to the Child-Pugh scores, patients are classified into three classes (Child class A, B, and C with CP scores 5-6, 7-9, and 10-15, respectively) | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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RFA, liver cancer, surgical resection