A Multi-center, Retrospective Analysis of Clinical Character, Outcome and Prognosis of Lymphoepithelioma-like Carcinoma

Study Overview
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Brief Summary
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The investigators retrospective collect the clinical data of patients diagnosed with lymphoepithelioma-like carcinoma, including primary site, gender, age, smoking history, tumor stage, time of initial treatment, EBV-DNA copy number, first-line treatment and survival status.

Detailed Description
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Lymphoepithelioma-like carcinoma (LELC) is a rare EBV-related tumor. Its histology is similar to that of nasopharyngeal carcinoma. In 2004, the WHO classified LELC into one subtype of large cell carcinoma, and the 2015 WHO classified it as other and unclassified cancers. LELC can originate in many organs, including parotid glands, throat, lungs, digestive tract, genitourinary system, etc. Driver gene mutations are rarely seen, and most of them are PD-L1 positive. In terms of treatment, there is no standard first-line treatment for lymphoepithelioma-like cancer. Patients with early-stage lymphoepithelioma-like cancer can receive surgery or radiotherapy, while palliative radiotherapy or chemotherapy is the main treatment for patients in advanced stage. The survival time is about 107 months, the 5-year OS is 59.5%, which is better than the prognosis of lung squamous cell carcinoma in the same period. A retrospective study of Sun yat-sen University Cancer Hospital included 127 patients with advanced lung LELC who received first-line chemotherapy between 2007 and 2018. Gemcitabine and platinum based chemotherapy and paclitaxel and platinum based regimens are significantly better than pemetrexed and platinum, but most of the current studies on lymphoepithelioma-like cancer focus on LELC that originates in the lung. But for other sites, such as parotid glands, liver, digestive tract, are mostly based on case reports, and there are few retrospective studies with large samples to explore their clinical features and treatment outcome. Therefore, investigators designed this retrospective clinical study to analyze the clinical characteristics, treatment, survival, and prognostic risk factors of patients with lymphoepithelioma-like carcinoma in order to summary the clinical character and guide treatment.

Official Title
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A Multi-center, Retrospective Analysis of Clinical Character, Outcome and Prognosis of Lymphoepithelioma-like Carcinoma

Conditions
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Lymphoepithelioma-Like Carcinoma, Lymphoepithelioma-Like Carcinoma of Thymus, Lung Cancer

Intervention / Treatment
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* Other: Non-intervention research


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1. Lymphoepithelioma-like carcinoma confirmed by histopathology; 2. The primary lesion does not involve the nasopharynx; 3. Complete data for patient's character, laboratory and imaging test, treatment and follow-up are available. Exclusion Criteria: 1. Concomitant with other tumor components at the time of diagnosis; 2. Have a history of any other malignant tumors; 3. Lack of complete data
Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| pulmonary lymphoepithelioma-like carcinoma<br>The primary site of lymphoepithelioma-like carcinoma locates in the lungs. | Other: Non-intervention research<br>* Non-intervention research<br>|
| lymphoepithelioma-like carcinoma of thymus<br>The primary site of lymphoepithelioma-like carcinoma locates in the thymus. | Other: Non-intervention research<br>* Non-intervention research<br>|
| lymphoepithelioma-like carcinoma of salivary glands<br>The primary site of lymphoepithelioma-like carcinoma locates in the parotid gland or submandibular gland. | Other: Non-intervention research<br>* Non-intervention research<br>|
| lymphoepithelioma-like carcinoma of stomach<br>The primary site of lymphoepithelioma-like carcinoma locates in the stomach. | Other: Non-intervention research<br>* Non-intervention research<br>|
| lymphoepithelioma-like carcinoma of esophagus<br>The primary site of lymphoepithelioma-like carcinoma locates in the esophagus. | Other: Non-intervention research<br>* Non-intervention research<br>|
| lymphoepithelioma-like carcinoma of liver<br>The primary site of lymphoepithelioma-like carcinoma locates in the liver. | Other: Non-intervention research<br>* Non-intervention research<br>|
| lymphoepithelioma-like carcinoma of ovaries<br>The primary site of lymphoepithelioma-like carcinoma locates in the ovaries. | Other: Non-intervention research<br>* Non-intervention research<br>|
| lymphoepithelioma-like carcinoma of cervix<br>The primary site of lymphoepithelioma-like carcinoma locates in the cervix. | Other: Non-intervention research<br>* Non-intervention research<br>|
| lymphoepithelioma-like carcinoma of tonsil<br>The primary site of lymphoepithelioma-like carcinoma locates in the tonsil. | Other: Non-intervention research<br>* Non-intervention research<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression-free survival | The length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease but it does not get worse. | From date of diagnosis until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 12 months. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overall survival | The length of time from either the date of diagnosis or the start of treatment for a disease, such as cancer, that patients diagnosed with the disease are still alive. | From date of diagnosis until the date of death from any cause, whichever came first, assessed up to 24 months. |