The First United Arab Emirates National Representative Birth Cohort Study

Study Overview
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Brief Summary
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In this study, a multidisciplinary team of researchers was established including credible researchers from the UAE, Australia and the United Kingdom to launch the First United Arab Emirates 3-year birth cohort study. The study aims to recruit 250 pregnant Emirati women within their first trimester, which is defined by the study as from 8 to 12 weeks pregnant, recruited from obstetric and gynaecology clinics in the UAE. Participants will be recruited via face to face interviews and will receive a total of 11 visits with 1 visit in each trimester of pregnancy and 8 visits after delivery. Maternal data collection includes, socio-demographic and lifestyle factors, dietary intake, anthropometric measurements, physical activity, maternal psychological state, and blood samples for biochemical analysis. Post-partum, visits will take place when the child is 0.5, 4, 6, 9, 12, 18, and 24 months old, with data collection including infant anthropometric measurements, young child feeding practices, dietary intake, supplement use and the eating environment at home, as well as all maternal data collection described above, apart from blood samples. Additional data collection for the child includes developmental assessments taking place at three timepoints, 1) within 2 weeks of birth, 2) at 10-14 months and 3) at 22 - 26 months of age. Developmental assessments for the infant include vision, health, neurological examination, neurodevelopmental and sleep assessments.

Official Title
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The First United Arab Emirates National Representative Birth Cohort Study

Conditions
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Child and Maternal Health

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Emirati Nationality Within first trimester of pregnancy (between 8 -12 weeks of gestation) Singleton pregnancy Absence of major illness preconception (Diabetes mellitus, hypertension, kidney disease, cancer, epilepsy, severe psychiatric illness, and other chronic diseases of infections such as autoimmune disorders, human immunodeficiency virus, and hepatitis). Exclusion Criteria: Non-Emirati Unconfirmed viable, intrauterine pregnancy at first obstetric ultrasound during first trimester Twin or multiple gestation pregnancy and a history of multiple gestations History of chronic illness (i.e., T2DM, hypertension, etc.) Previously given birth to babies with malformation, intellectual disability, or inborn errors of metabolism. Experience of a miscarriage before 28 weeks of gestation On significant regular medications, including insulin, anti-hypertensive agents, psychotropic medications, anti-epileptic drugs, steroids, immune-suppressive agents, and chemotherapeutic agents.

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maternal Dietary Intake | 24 hour dietary recall | 1st Trimester One point during weeks 1 - 13 | 
| Maternal Dietary Intake | 24 hour dietary recall | 2nd Trimester. One point during Weeks 14 - 26 | 
| Maternal Dietary Intake | 24 hour dietary recall | 3rd Trimester One point during weeks 27 - 42 | 
| Maternal Dietary Intake | 24 hour dietary recall | 4 months post natal | 
| Maternal Dietary Intake | 24 hour dietary recall | 18 months post natal | 
| Maternal Dietary Intake | Food frequency questionnaire | 1st Trimester - One point during weeks 1 - 13 | 
| Maternal Dietary Intake | Food frequency questionnaire | 2nd Trimester. One point during Weeks 14 - 26 | 
| Maternal Dietary Intake | Food frequency questionnaire | 3rd Trimester One point during weeks 27 - 42 | 
| Maternal Dietary Intake | Food frequency questionnaire | 4 months post natal | 
| Maternal Dietary Intake | Food frequency questionnaire | 18 months post natal | 
| Maternal Weight | Measured in Kilograms | 1st Trimester - One point during weeks 1 - 13 | 
| Maternal Weight | Measured in Kilograms | 2nd Trimester. One point during Weeks 14 - 26 | 
| Maternal Weight | Measured in Kilograms | 3rd Trimester One point during weeks 27 - 42 | 
| Maternal Weight | Measured in Kilograms | 0.5 months post natal | 
| Maternal Weight | Measured in Kilograms | 4 months post natal | 
| Maternal Weight | Measured in Kilograms | 6 months post natal | 
| Maternal Weight | Measured in Kilograms | 9 months post natal | 
| Maternal Weight | Measured in Kilograms | 12 months post natal | 
| Maternal Weight | Measured in Kilograms | 18 months post natal | 
| Maternal Weight | Measured in Kilograms | 24 months post natal | 
| Maternal Blood Pressure | Measured sphygmomanometer, in millimetres of mercury. | 1st Trimester - One point during weeks 1 - 13 | 
| Maternal Blood Pressure | Measured sphygmomanometer, in millimetres of mercury. | 2nd Trimester. One point during Weeks 14 - 26 | 
| Maternal Blood Pressure | Measured sphygmomanometer, in millimetres of mercury. | 3rd Trimester One point during weeks 27 - 42 | 
| Maternal Physical Activity | International Physical Activity Questionnaire | 2nd Trimester. One point during Weeks 14 - 26 | 
| Maternal Physical Activity | International Physical Activity Questionnaire | 12 months post natal | 
| Maternal Physical Activity | International Physical Activity Questionnaire | 24 months post natal | 
| Child neurodevelopmental assessment | INTERGROWTH-21st Neurodevelopment Assessment | 24 months post-natal | 
| Child neurodevelopmental assessment | Oxford Neonatal Neurodevelopmental Assessment tool | 12 months post-natal | 
| Child neurodevelopmental assessment | Neonatal Neurodevelopmental Assessment tool | 0.5 months post-natal | 
| Child anthropometric assessment (MUAC) | Weight (kgs), length, head circumference, mid-upper arm circumference | 0.5 months post-natal | 
| Child anthropometric assessment (MUAC) | Weight (kgs), length, head circumference, mid-upper arm circumference | 4 months post-natal | 
| Child anthropometric assessment (MUAC) | Weight (kgs), length, head circumference, mid-upper arm circumference | 6 months post-natal | 
| Child anthropometric assessment (MUAC) | Weight (kgs), length, head circumference, mid-upper arm circumference | 9 months post-natal | 
| Child anthropometric assessment (MUAC) | Weight (kgs), length, head circumference, mid-upper arm circumference | 12 months post-natal | 
| Child anthropometric assessment (MUAC) | Weight (kgs), length, head circumference, mid-upper arm circumference | 18 months post-natal | 
| Child anthropometric assessment (MUAC) | Weight (kgs), length, head circumference, mid-upper arm circumference | 24 months post-natal | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maternal hemoglobin | Hemoglobin levels measured in grams per deciliter | 1st Trimester - One point during weeks 1 - 13 | 
| Maternal hemoglobin | Hemoglobin levels measured in grams per deciliter | 3rd Trimester One point during weeks 27 - 42 | 
| Maternal Ferritin | Serum ferritin measured in nanograms per milliliter | 1st Trimester - One point during weeks 1 - 13 | 
| Maternal Ferritin | Serum ferritin measured in nanograms per milliliter | 3rd Trimester One point during weeks 27 - 42 | 
| Maternal Folate | Serum folate measured in nanograms per milliliter | 1st Trimester - One point during weeks 1 - 13 | 
| Maternal Folate | Serum folate measured in nanograms per milliliter | 3rd Trimester One point during weeks 27 - 42 | 
| Maternal Vitamin D | Serum 25 hydroxyvitamin D measured in nanomole per liter | 1st Trimester - One point during weeks 1 - 13 | 
| Maternal Vitamin D | Serum 25 hydroxyvitamin D measured in nanomole per liter | 3rd Trimester One point during weeks 27 - 42 | 
| Maternal Vitamin A | Serum retinol measured in micrograms of retinol activity equivalent | 1st Trimester - One point during weeks 1 - 13 | 
| Maternal Vitamin A | Serum retinol measured in micrograms of retinol activity equivalent | 3rd Trimester One point during weeks 27 - 42 | 
| Maternal Vitamin B12 | Serum B12 measured in picogram per millilitre | 1st Trimester - One point during weeks 1 - 13 | 
| Maternal Vitamin B12 | Serum B12 measured in picogram per millilitre | 3rd Trimester One point during weeks 27 - 42 | 
| Maternal zinc concentration | Serum zinc measured in micromole per litre | 1st Trimester - One point during weeks 1 - 13 | 
| Maternal zinc concentration | Serum zinc measured in micromole per litre | 3rd Trimester One point during weeks 27 - 42 | 
| Maternal lead concentration | Serum lead measured in micromole per litre | 3rd Trimester One point during weeks 27 - 42 |