Application of ROTEM Technology in Aortic Surgery

Study Overview
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Brief Summary
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Comparison of the diagnostic capabilities of rotational thromboelastometry (ROTEM) and standard coagulogram in the detection of disorder and correction of the hemostasis system in the perioperative period in patients who underwent surgical intervention on the aorta under cardiopulmonary bypass and or circulatory arrest.

Detailed Description
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The patient is monitored in the intensive care unit according to the following scheme: ROTEM (NATEM, INTEM, EXTEM, FIBTEM; with high clotting time (CT) values in INTEM - HEPTEM is done) and a coagulogram (activated coagulation time (ACT), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen, antithrombin III, platelet aggregation) are done on admission and after 6 hours - with a smooth course of the perioperative period. If it is necessary or the development of disorders in the form of bleeding or thrombosis that require correction, ROTEM and a coagulogram are done, treatment is carried out, and after elimination of the causes, ROTEM and a coagulogram are examined in dynamics to assess the effectiveness of the therapy.

Official Title
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Application of ROTEM Technology in Aortic Surgery Under Cardiopulmonary Bypass and Circulatory Arrest

Conditions
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Aortic Surgery, Coagulation Management

Intervention / Treatment
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* Device: ROTEM and standard coagulation tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age from 18 to 80 years. Patients after surgical interventions on the aorta with cardiopulmonary bypass and/or circulatory arrest (operations on the ascending aorta, aortic arch and thoracoabdominal aorta). Exclusion Criteria: Patients with other cardiac surgery, including isolated endovascular interventions on the aorta.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: ROTEM and standard coagulation tests|ROTEM and standard coagulation tests assessment|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The coagulation index | Сhanges of the coagulation index | an average of during the first day after surgery | 
| Activated coagulation time | Сhanges of the activated coagulation time | an average of during the first day after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of repeated operations | Percentage of repeated operations | an average of 24 hours after surgery | 
| Percentage of multiple organ failure | Percentage of multiple organ failure | an average of 24 hours after surgery | 
| Percentage of serious infectious complication | Percentage of serious infectious complication | an average of 24 hours after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ROTEM, coagulation tests, coagulation disorders, aortic surgery