Effects of Postoperative Analgesic Modalities on Plasma Creatine Phosphokinase(CPK) Levels After Knee Artroplasty

Study Overview
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Brief Summary
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Regional anesthesia and analgesia technics are widely and securely used during orthopedic surgery. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. We aimed to examine plasma CPK(creatine phosphokinase) levels to see whether myotoxicity occurs or not after suprainguinal fascial plane block is applied to patients undergoing knee artroplasty surgery.

Detailed Description
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During 2 months period all elligible patients undergoing knee artoplasty surgery will be included in the study. Different postoperative analgesic modalities will be used according to the anesthesists experience. During routine blood sample tests plasma CPK levels will be tested 3 times of all patients.(preoperative, postoperative 6th hour, postoperative 24th hour) this data will be recorded for 2 months. After this period of time data will be analysed and patients will be grouped according to the analgesic modalities used.

Official Title
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Effects of Postoperative Analgesic Modalities on Plasma Creatine Phosphokinase(CPK) Levels After Knee Artroplasty

Conditions
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Myotoxicity

Intervention / Treatment
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* Other: suprainguinal fascia iliaca block


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA 1-3 knee artoplasty patients under spinal anesthesia Exclusion Criteria: local anesthetic allergies myopathies coagulopathies Obstructive sleep apne syndrome hearth diseases liver diseases kidney diseases thyroid-parathyriod dieseas hiperlipidemias using Statins(HMG-CoA reductase inhibitors) pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| SFIPB<br>suprainguinal fascia iliaca plane block with 50ml of %0.25 bupivacaine will be used for postoperative analgesia . | Other: suprainguinal fascia iliaca block<br>* Suprainguinal fascia iliaca block will be performed after the end of surgery for postoperative analgesia.<br>|
| control<br>Fascia iliac block will not be applied to this group. Postoperative analgesia will be provided with other analgesia modalities. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CPK levels | Change from Baseline serum creatine phosphokinase at 24 hours | at postoperative 24th hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of patients requesting rescue analgesics | Intravenous administration of meperidine 25 mg as a rescue analgesic is planned for patients who complain of severe pain despite multimodal analgesia. | up to 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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bupivacaine, myotoxicity, creatine phosphokinase,SFIPB