Vitamin d Levels in Children With Bacterial Meningitis

Study Overview
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Brief Summary
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The purpose of this study is to determine whether deficiency of Vitamin D has association with outcomes of children with bacterial meningitis.

Detailed Description
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Vitamin D deficiency has been proved in serious diseases patients, including patients in shock, however, few study have been done about association between deficiency of Vitamin D and outcomes of children with bacterial meningitis. in our study, we will observe incidence of complication and severity of complication between patients who have different Vitamin D status.

Official Title
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Association of Serum 25-hydroxyvitamin D Levels and Outcomes in Children With Bacterial Meningitis

Conditions
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Bacterial Meningitis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Probable bacterial meningitis patients: Clinical manifestation (Any person with sudden onset of fever (> 38.5 °C rectal or 38.0 °C axillary) and one of the following signs: neck stiffness, altered consciousness or other meningeal sign) with cerebrospinal fluid examination showing at least one of the following: A. turbid appearance; B.leukocytosis (> 100 cells/mm3); C.leukocytosis (10-100 cells/ mm3) AND either an elevated protein (> 100 mg/dl) or decreased glucose (< 40 mg/dl) Confirmed bacterial meningitis patients: A case that is laboratory-confirmed by growing (i.e. culturing) or identifying (i.e. by Gram stain or antigen detection methods) a bacterial pathogen (Hib, pneumococcus or meningococcus) in the cerebrospinal fluid or from the blood in a child with a clinical syndrome consistent with bacterial meningitis Exclusion Criteria: Congenital immunodeficiency patients HIV patients Patients with corticosteroid treatment for long time Patients with disorders in adrenal gland and pituitary gland and hypothalamus Patients with tuberculosis

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| vitamin d level change | Serum vitamin d level will be detected in the first day of hospitalization and twenty-eighth day of hospitalization, no vitamin d supplementation during this time | change in serum vitamin d level from baseline to 28 days after initial hospitalization | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical assessment of disease severity with Glasgow score | Disease severity will be assessed with Glasgow score in the first day of hospitalization | 1 day | 
| Clinical assessment of disease severity with Glasgow score | Disease severity will be assessed with Glasgow score in the seventh day of hospitalization | 7 day | 
| Clinical assessment of disease severity with Glasgow score | Disease severity will be assessed with Glasgow score in the twenty-eighth day of hospitalization | 28 day | 
| Clinical assessment of disease severity with pediatric critical illness score | Disease severity will be assessed with pediatric critical illness score in the first day of hospitalization | 1 day | 
| Clinical assessment of disease severity with pediatric critical illness score | Disease severity will be assessed with pediatric critical illness score in the seventh day of hospitalization | 7 day | 
| Clinical assessment of disease severity with pediatric critical illness score | Disease severity will be assessed with pediatric critical illness score in the twenty-eighth day of hospitalization | 28 day | 
| Clinical assessment of disease severity with cerebrospinal fluid examination | Cerebrospinal fluid examination including white blood cell count, protein concentration and glucose concentration in cerebrospinal fluid | 1 day | 
| Clinical assessment of disease severity with cerebrospinal fluid examination | Cerebrospinal fluid examination including white blood cell count, protein concentration and glucose concentration in cerebrospinal fluid | 7 day | 
| Clinical assessment of disease severity with cerebrospinal fluid examination | Cerebrospinal fluid examination including white blood cell count, protein concentration and glucose concentration in cerebrospinal fluid | 28 day | 
| Assessment of complications | Assessment of complications include whether patients have complications, which kind of complication patients suffered, and whether needing surgical therapy. | 1 day | 
| Assessment of complications | Assessment of complications include whether patients have complications, which kind of complication patients suffered, and whether needing surgical therapy. | 7 day | 
| Assessment of complications | Assessment of complications include whether patients have complications, which kind of complication patients suffered, and whether needing surgical therapy. | 28 day |