Impairment of Central Coherence in Restrictive Anorexia Nervosa (CoCA)

Study Overview
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Brief Summary
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The current etiological pathological model of anorexia nervosa is poly-factorial involving individual genetic and psychological factors, in close interaction with environmental, family and socio-cultural factors. Among these factors, this study focuses on the central coherence process (cognitive ability to integrate complex information into a comprehensive meaning), in the active phase of the disease. Therefore, patients followed in the addiction service of the Nantes University Hospital will perform neuropsychological tests assessing executive functions involved in the process of central coherence. Impairment of central coherence process could act as a maintenance factor of the disease, particularly in connection with body dysmorphic disorder. The therapeutic perspectives acting on the central coherence process like cognitive remediation deserve to deepen knowledge on the cognitive profile of patients with anorexia nervosa.

Official Title
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Impairment of Central Coherence in Restrictive Anorexia Nervosa: Single-center and Case-control Study

Conditions
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Anorexia Nervosa

Intervention / Treatment
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* Behavioral: One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: For the patients : Woman. Aged of more than 15 years and 3 months. Followed in the addiction service of the University Hospital of Nantes (consultations and / or hospitalizations) for Restrictive Anorexia Nervosa (according to the diagnostic criteria of DSM-IV-TR). French language mastered. Having signed the consent if major and if not the legal representatives have signed the consent (for minors). For the volunteers : Women. Aged of more than 15 years and 3 months. French language mastered. Having signed the consent if major and if not the legal representatives have signed the consent (for minors). Exclusion Criteria: For the patients : Man Age under 15 years and 3 months old Current Renutrition by nasogastric tube Personal history of: Head injury, neurodegenerative diseases, epilepsy unbalanced, unbalanced endocrine disorder, mental retardation Support for current or past cognitive remediation Opposition of the patient and / or his legal representatives if minor Subject under legal guardianship Current participation or in the past to pharmacological research protocol (time since the end of their participation in the protocol less than one year) French language not mastered For the volunteers : Man Age under 15 years and 3 months old Current Renutrition by nasogastric tube Personal history of: Eating disorders Head injury, neurodegenerative diseases, epilepsy unbalanced, unbalanced endocrine disorder, mental retardation Support for current or past cognitive remediation Opposition of the volunteer and / or his legal representatives if minor Subject under legal guardianship Current participation or in the past to pharmacological research protocol (time since the end of their participation in the protocol less than one year) French language not mastered

Ages Eligible for Study
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Minimum Age: 15 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Patients<br>patients followed in the addiction service of the University Hospital of Nantes (consultations and / or hospitalizations) for restrictive anorexia nervosa | Behavioral: One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment<br>* The content of the assessment will be the same for all subjects and will consist of a part of cognitive assessment (National Reading Test, Rey Osterreich Complex Figure, Hayling Sentence Completion Task, verbal memory, digit sequencing, token motor task, verbal fluencies, symbol coding, tower of London) and self-assessment (Mini International Neuropsychiatric Interview, Beck Depression Inventory, State Trait Anxiety Inventory, Wender Utah Rating Scale, Adult Self-Report Scale Symptom Checklist, UPPS Impulsive Behavior Scale)<br>|
| Other: Healthy volunteers<br>control subjects matched for age and sex with the patients | Behavioral: One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment<br>* The content of the assessment will be the same for all subjects and will consist of a part of cognitive assessment (National Reading Test, Rey Osterreich Complex Figure, Hayling Sentence Completion Task, verbal memory, digit sequencing, token motor task, verbal fluencies, symbol coding, tower of London) and self-assessment (Mini International Neuropsychiatric Interview, Beck Depression Inventory, State Trait Anxiety Inventory, Wender Utah Rating Scale, Adult Self-Report Scale Symptom Checklist, UPPS Impulsive Behavior Scale)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentages for types I and III of the copy of the figure of Rey |  | 90 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Average scores for all cognitive and psychiatric tests |  | 90 minutes | 
| Measure of relationships between average scores for all cognitive and psychiatric tests and socio-demographic and clinical data |  | 90 minutes |