Long Term (1 Year) Respiratory Sequelae in Children Surviving an Acute Respiratory Distress Syndrome

Study Overview
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Brief Summary
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The purpose of this study is to assess long term (1 year) respiratory sequelae in children surviving an acute respiratory distress syndrome

Detailed Description
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The acute respiratory distress syndrome (ARDS) has a high mortality rate in children. Adverse long term sequelae, and in particular respiratory sequelae, have been described mainly in adults. Decrease in diffusing capacity, lung volume and exercise tolerance were observed. Lung function parameters improve during the follow-up until 6 month after discharge from the pediatric intensive care unit (PICU). After that, abnormalities in PFT are observed in a significant proportion of patients. Only two studies described long-term sequelae in children surviving to an ARDS and their results are conflicting. Two studies carried out in adults described the morphologic long-term sequelae by thoracic computed tomography. They showed reticular pattern with a striking anterior distribution in most patients evaluated more than 6 months after discharge from the PICU. There is, to our knowledge, no study describing morphologic pulmonary sequelae by thoracic computed tomography in children surviving to ARDS. Respiratory assessment: respiratory sequelae in children surviving to the acute respiratory distress syndrome will be evaluated 1 year after discharge from the PICU. Assessment will include a clinical evaluation (respiratory history and physical examination), respiratory function tests and thoracic computed tomography

Official Title
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Long Term (1 Year) Respiratory Sequelae in Children Surviving Acute Respiratory Distress Syndrome

Conditions
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Acute Respiratory Distress Syndrome

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: children surviving to an acute respiratory distress syndrome and alive 1 year after discharge from the PICU Exclusion Criteria: children suffering from neuromuscular disease children presenting symptoms of chronic respiratory disease before ARDS

Ages Eligible for Study
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Minimum Age: 1 Year
Maximum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dynamic lung compliance |  | 1 year +- 2 months after discharge from ICU | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| respiratory complaints (cough, wheeze,dypnea at rest on exertion, bronchitis, pneumonia |  | 1 year +- 2 months after discharge from ICU | 
| extend of ground glass opacification (CT scan) |  | 1 year +- 2 months after discharge from ICU | 
| extend of intense parenchymal opacification |  | 1 year +- 2 months after discharge from ICU | 
| extend of reticular pattern |  | 1 year +- 2 months after discharge from ICU | 
| extend of decreased attenuation due to emphysema |  | 1 year +- 2 months after discharge from ICU | 
| extend of decreased attenuation attributable to small-airway disease |  | 1 year +- 2 months after discharge from ICU | 
| carbon monoxide diffusing capacity |  | 1 year +- 2 months after discharge from ICU | 
| Pulse oxymetry oxygen saturation at the end of a 6 min walk test |  | 1 year +- 2 months after discharge from ICU | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute respiratory distress syndrome, Children, Long term respiratory sequelae, Pulmonary function tests, Computed tomography, lung