Role of the Environment and Endocrine Disruptors in Child Cryptorchidism

Study Overview
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Brief Summary
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Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.

Detailed Description
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Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.

Official Title
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Role of the Environment and Endocrine Disruptors in Child Cryptorchidism

Conditions
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Cryptorchidism

Intervention / Treatment
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* Other: Measure of the exposure of parent of male with /without cryptorchidism to endocrine disruptors


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: - Parents of male children from the neonatal period to 18 years of age (during surgery) with cryptorchidism Exclusion criteria: Parents of children without endocrine disease. (adrenal, hypothalamic-pituitary, phosphocalcic, thyroid, diabetes, etc.) Parents of children without an associated genital or urinary defect (hypospadias, micropenis, renal and bladder abnormalities) Testicular Ectopia (testis outside of normal migration path) Anorchidism and evanescent testicles, united or bilateral Abnormalities of the abdominal wall (laparoschisis, omphalocele, Prune Belly) Cryptorchidism integrating in the context of a polymalformative syndrome, including neurological.

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 18 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Parent of patient with cryptorchidism<br>parent exposition of endocrine disruptors | Other: Measure of the exposure of parent of male with /without cryptorchidism to endocrine disruptors<br>* Measure of the exposure of parent of patient with/without cryptorchidism to endocrine disruptors (job exposure, during pregnancy)<br>|
| Parent of patient without cryptorchidism<br>Parent exposition of endocrine disruptors | Other: Measure of the exposure of parent of male with /without cryptorchidism to endocrine disruptors<br>* Measure of the exposure of parent of patient with/without cryptorchidism to endocrine disruptors (job exposure, during pregnancy)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| frequency of the job exposure of the parents of endocrine disruptors | Measure of the frequency of endocrine disruptors assessed by european questionary QLK4-1999-01422 (simplified version ) | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| comparison of cryptorchid and non-cryptorchid children born to parents with isolated exposure vs multiple exposures | Assessement by the Job-exposure matrix EDC (Environment disrupting chemicals) | 1 day | 
| Comparison of frequencies of exposure to endocrine disruptors (Environmental Disrupting Chemicals) in parents giving birth to a congenital cryptorchid child vs child not cryptorchid at birth but with secondary cryptorchidism. | presence of cryptorchidism at birth or secondarily | 1 day | 
| identify food exposure criteria (phytoestrogen or EDC pesticides) associated with the presence of a cryptorchid. | parents will be asked about their diet | 1 day | 
| Constitution of collection of biological samples from children with non-palpable bilateral cryptorchidism | The aim is only to make a collection of blood samples. Anonymous samples will be used later in order to improve knowledge of the cryptorchidism. | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cryptorchidism, environmental exposition, endocrine disruptors