Stroke Volume Variation and Pulse Pressure Variation as Predictors of Fluid Responsiveness During Kidney Transplantation

Study Overview
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Brief Summary
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The aim pf this prospective study is to investigate the ability of stroke volume variation (SVV) and pulse pressure variation (PPV) to predict fluid responsiveness in patients undergoing kidney transplantation.

Detailed Description
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Optimal intraoperative fluid management guided by central venous pressure (CVP), a traditional intravascular volume status indicator has been established to improve transplanted graft function during renal transplantation. Recently, stroke volume variation (SVV) and pulse pressure variation (PPV), dynamic preload indices derived from the arterial waveform are increasingly advocated as predictors of fluid responsiveness in anesthetized patients and critically ill patients. However, their usefulness in renal failure patients undergoing renal transplantation has not been investigated. Thus, the aims of this study is to investigate accuracy of SVV and PPV for predicting fluid responsiveness in patients undergoing kidney transplantation.

Official Title
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Utility of Stroke Volume Variation and Pulse Pressure Variation for Predicting Fluid Responsiveness in Chronic Renal Failure Patients Undergoing Kidney Transplantation

Conditions
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Kidney Transplantation

Intervention / Treatment
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* Procedure: Fluid loading


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: - chronic renal failure patients undergoing renal transplantation Exclusion Criteria: patients with cardiac arrhythmia patients with reduced left ventricular function (EF < 40%) patients with valvular heart disease patients intracardiac shunt patients with pulmonary hypertension patients with extensive peripheral vascular disease patients with preoperative use of vasopressors or inotropics

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: SVV and PPV<br>SVV(stroke volume variation): recorded using the Flotrac/Vigileo system (Edwards Lifesciences) PPV(pulse pressure variation): recorded using philips Intelivue MP70 monitors (Philips Medical System) Intervention: Other: Fluid loading using HES 130/0.4; voluven; Fresenius Kabi; Stans, Switzerland | Procedure: Fluid loading<br>* fluid loading was performed by using 7ml/kg of 6% hydroxyethyl starch within 10 min to all patients<br>* Other names: HES 130/0.4; voluven; Fresenius Kabi; Stans, Switzerland;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| stroke volume variation from Flo stroke volume variation from FloTrac/Vigileo system | predictable of stroke volume variation from FloTrac/Vigileo system for fluid responsiveness | within 5 minutes after fluid expansion | 
| pulse pressure variation from philips Intelivue MP70 monitor | predictable of pulse pressure variation from philips Intelivue MP70 monitor for fluid responsiveness | within 5 minutes after fluid expansion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Fluid Responsiveness, Pulse Pressure Variation, Stroke Volume Variation