linjc16/ctgov huggingface dataset:
The Influence of tDCS on the Arm and Hand Function in Stroke Patients

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether tDCS in combination with motor training can improve hand and arm function in stroke patients.

Conditions
-----------------
Transcranial Direct Current Stimulation, Cerebrovascular Accident (CVA)

Intervention / Treatment
-----------------
* Device: transcranial direct current stimulation (tDCS)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Stroke patients onset > 6 months First ever stroke Decreased hand and arm function Mini Mental State Examination (>24) Exclusion Criteria: Depression Pregnancy Alcohol abuse Aneurysm clips Pacemaker Neurostimulator Implemented defibrillator Magnetically activated implant or device implemented pump Spinal cord simulator Implemented hearing aid Artificial or prosthetic limb Metal parts in the body Any external or internal metal Artificial heart valve Other implants History of brain surgery Migraine Family history of Epilepsy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Upper limb motor function training + tDCS<br>Bi-hemispheric tDCS with motor function training | Device: transcranial direct current stimulation (tDCS)<br> <br> |
| Sham Comparator: upper limb motor function training + sham tDCS<br>sham tDCS with motor function training | Device: transcranial direct current stimulation (tDCS)<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of Fugl-Meyer assessment (FMA) score |  | Change from baseline in FMA score on the 3rd intervention day; change from baseline in FMA score at 1 week post intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of Modified Ashworth scale (MAS) |  | Change from baseline in MAS scale on the 3rd intervention day; change from baseline in MAS scale at 1 week post intervention |
Effect of AXOS on the Colon Metabolism in Healthy Volunteers

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the effect of AXOS on parameters of colon metabolism and gut health

Official Title
-----------------
Effect of AXOS on the Colon Metabolism in Healthy Volunteers

Conditions
-----------------
Gut Health

Intervention / Treatment
-----------------
* Dietary Supplement: Arabinoxylanoligosaccharides
* Dietary Supplement: Maltodextrine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy volunteers regular dietary pattern (3 meals/day) age: 18-45y BMI: 18,5-27 kg/m2 Exclusion Criteria: intake of antibiotics 1 month prior to the study abdominal surgery in the past, with the exception of appendectomy intake of medication influencing the gastro-intestinal system 14 days prior to the study in treatment at a dietician serious liver- or kidney failure vegetarians intake of pre- and/or probiotics Exposure to radioactivity 1 year prior to the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Arabinoxylanoligosaccharides (AXOS)<br>AXOS (2 x 5g WBE/day) | Dietary Supplement: Arabinoxylanoligosaccharides<br> <br> |
| Placebo Comparator: Maltodextrine (placebo)<br>Maltodextrine (2 x 5g/day) | Dietary Supplement: Maltodextrine<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Fecal water toxicity |  | Participants are followed for 10 weeks, with measurements on 4 specific time points |
Mixed Urinary Incontinence Surgical Trial

Study Overview
=================
Brief Summary
-----------------
Surgical management of mixed urinary incontinence

Detailed Description
-----------------
Study to evaluate role of anti-incontinent surgery Burch colposuspension Tension free vaginal tape Trans obturator tape for the management of mixed urinary incontinence .

Official Title
-----------------
Surgical Management of Mixed Urinary Incontinence

Conditions
-----------------
Med: Urinary Incontinence (Stress, Urge, Mixed)

Intervention / Treatment
-----------------
* Procedure: Burch Colposuspension
* Procedure: trans obturator tape
* Procedure: tension free vaginal tape


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with Mixed urinary incontinence Exclusion Criteria: Women with associated gynecological surgery e.g. uterine prolapse, previous anti-incontinence surgery, intrinsic sphincter deficiency (ISD), and medical disorders affecting the bladder innervation as diabetes mellitus were excluded from the study. Women who improved on medical treatment with persistence of stress element only were also excluded.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Burch<br>Burch Colposuspension | Procedure: Burch Colposuspension<br>* Anti-incontinent surgery<br>|
| Experimental: Trans Obturator Tape<br>Trans Obturator Tape sling | Procedure: trans obturator tape<br>* Anti-incontinent surgery<br>|
| Experimental: Tension free vaginal tape<br>Tension free vaginal tape sling | Procedure: tension free vaginal tape<br>* Anti-incontinent surgery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cure of Mixed incontinence | compare the 3 groups as regard cure rate of both Components of mixed incontinence | 1 year |
Epidemiological Study of Dry Eye Disease in Stavanger: Dry Eye Disease in Patients Treated With Intravitreal Injections

Study Overview
=================
Brief Summary
-----------------
To investigate prevalence of dry eye disease in Norwegian patients with age-related macular degeneration receiving intravitreal injections, as well as to reveal possible risk factors of DED in this population.

Detailed Description
-----------------
Questionaires (OSDI, McMonnies) and clinical investigation using the Oculus 5 Keratograph for objective ocular surface evaluation. Tear fluid samples will be collected for later biochemical analysis.

Official Title
-----------------
Epidemiological Study of Dry Eye Disease in Stavanger: Dry Eye Disease in Patients With Age-related Macular Degeneration Treated With Intravitreal Injections

Conditions
-----------------
Dry Eye

Intervention / Treatment
-----------------
* Diagnostic Test: Oculus Keratograph. Schirmer test. Tear fluid sample.


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: AMD diagnosis Treated with intravitreal injection agents Exclusion Criteria: Not able to cooperate

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Oculus Keratograph. Schirmer test. Tear fluid sample.|Objective measurements of the ocular surface using Oculus 5 keratograph. Slit lamp examination and tear fluid sample using Schirmer strips.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dry eye disease in patients receiving intravitreal injections |  | 2022 |
Effects of Neuromuscular Pelvic Realigning Exercises on Pelvic Floor Muscle Function in Continent SubjectS

Study Overview
=================
Brief Summary
-----------------
The goal of this research study is to investigate the effect of a new neuromuscular approach for correcting pelvic alignment and improving pelvic floor muscle function. Investigators hypothesized that this approach would be significantly superior than no intervention to improve the ability of pelvic floor muscle contraction, measured by transabdominal sonography as bladder base elevation. Participants will be randomized to the intervention and control groups. while intervention group will receive five supervised sessions of pelvic realigning exercises, the control group will receive no intervention. Bladder base elevation will be measured as an indicator of pelvic floor muscle function, before and after one week intervention in both control and intervention groups.

Official Title
-----------------
Effects of Neuromuscular Pelvic Realigning Exercises on Pelvic Floor Muscle Function in Continent Subjects: A Randomized Control Trial

Conditions
-----------------
Pelvic Floor Muscle Weakness, Stress Urinary Incontinence, Pelvic Asymmetry

Intervention / Treatment
-----------------
* Other: neuromuscual realigning exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Positive Ober's test Exclusion Criteria: pelvic/low back pain in previous 12 months

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: intervention<br> | Other: neuromuscual realigning exercise<br>* neuromuscular realigning exercise<br>|
| No Intervention: control<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| bladder base elevation | the ability to contract pelvic floor muscle measured as bladder base elevation by transabdominal ultrasound | one week |
Vitamin D and Calcium Study

Study Overview
=================
Brief Summary
-----------------
Vitamin D aids in the body's ability to absorb calcium, it is a vital component in bone formation and break down. Reduced levels of vitamin D can indicate a vitamin deficiency and may depress serum calcium levels. The following is a list of common causes of vitamin D deficiency: lack of dairy products, alcohol usage, elderly, lack of exposure to sunlight, individuals with reduced mobility, GI malabsorption problems, dark complexion, severe liver damage, and renal failure. Many of these factors can be found in individuals with spinal cord injury. SCI results in disuse bone loss after acute injury, which continues with duration of injury. The goal of this study is to determine the effects of vitamin D and calcium supplements on calcium metabolism and vitamin D deficiency in individuals undergoing functional electrical stimulation (FES) stand retraining (SRT).

Official Title
-----------------
Vitamin D and Calcium Replacement/Supplementation in Subjects With Chronic Spinal Cord Injury

Conditions
-----------------
Spinal Cord Injury

Intervention / Treatment
-----------------
* Dietary Supplement: Vitamin D and Calcium


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Spinal Cord Injury (paraplegia or quadriplegia) Vitamin D deficiency Absolute deficient Vitamin D [25(OH)D] < 16 ng/ml Relative deficient Vitamin D [25(OH)D] <30ng/ml - participation in the FES/SRT study at Kessler Institute for Rehabilitation Exclusion Criteria: History of kidney stones History of bone disorders Currently pregnant

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Arm 1<br>Vitamin D & Calcium supplementation in FES | Dietary Supplement: Vitamin D and Calcium<br>* 2000 IU/day Vitamin D3 (cholecalciferol) and 1.3 g/day calcium carbonate will be taken for 15-20 weeks.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Effects of Vitamin D and Calcium supplements on calcium metabolism and vitamin D deficiency |  | 15-20 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
spinal cord injury, Vitamin D deficiency, Functional Electrical Stimulation
Bitter Chocolate or Orange Juice for Non-reactive Non-stress Test (NST) Patterns

Study Overview
=================
Brief Summary
-----------------
There are multiple factors affecting the variability and acceleration pattern of fetal heart rate (FHR) pattern. However, fetal activity is considered as the main determinant. Any factor decreasing fetal activity causes a decrease in FHR variability. Fetal activity may be stimulated by manual manipulation, sound, light, change in maternal position and maternal ingestion of glucose. Among those, ingestion of any kind of food or juice is most frequently practiced in outpatient settings. This is not only medical but also a social routine. In this study the investigators have chosen the two most popular so-called 'fetal accelerators', chocolate and orange juice against no intervention and tried to find any usefulness of these on non-reactive NST patterns.

Official Title
-----------------
Bitter Chocolate Versus Orange Juice for Non-reactive Non-stress Test (NST) Patterns: A Randomized Prospective Controlled Study

Conditions
-----------------
Nonreassuring Fetal Status

Intervention / Treatment
-----------------
* Dietary Supplement: Bitter chocolate
* Dietary Supplement: Orange juice


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: singleton pregnancies at 36 to 41 completed gestational weeks that have a non-reactive NST pattern without decelerations. Exclusion Criteria: multiple pregnancies, fetal anomaly, hypertension, intrauterine growth restriction, active labor, contractions or decelerations on NST, absence of a first or second trimester ultrasonography for accurate gestational dating, pre-gestational or gestational diabetes and known allergy to chocolate or orange

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Bitter chocolate<br>50 grams Ülker Golden %70 bitter chocolate, İstanbul, Turkey | Dietary Supplement: Bitter chocolate<br> <br> |
| Active Comparator: Orange juice<br>Ülker İçim Orange Juice 250 cc, İstanbul, Turkey | Dietary Supplement: Orange juice<br> <br> |
| No Intervention: Control<br>Sit and rest | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Increase in reactivity of NST |  | 30 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Increase in the maternal fetal movement perception |  | 30 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
non-stress test
Artificial Intelligence in Categorizing the Severity of Oxygenation by Incorporating the PEEP Into the Definition of ARDS in Ventilated Patients

Study Overview
=================
Brief Summary
-----------------
Artificial Intelligence in categorizing the severity of Oxygen in ventilated patients to predict initiation of treatment measures to improve mortality - P/FP ratio

Official Title
-----------------
Artificial Intelligence in Categorizing the Severity of Oxygenation by Incorporating the PEEP Into the Definition of ARDS in Ventilated Patients

Conditions
-----------------
ARDS

Intervention / Treatment
-----------------
* Diagnostic Test: P/FP ratio


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1. Intubated patients Exclusion Criteria: pediatric and neonates DNR patients Non intubated patients

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: P/FP ratio|PaO2/FiO2 X PEEP, SpO2/FiO2 X PEEP|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Artificial intelligence in categorizing the severity of oxygenation of ARDS in ventilated patients | To see the trend and difference between day 1, 2,3 and day 7 between P/F (PaO2/FiO2) and S/F(SaO2/FiO2) ratio to P/FP (PaO2/FiO2*PEEP) ratio and S/FP (SpO2/(FiO2*PEEP) ratio respectively. | Baseline ABG done at (approximately 4 hour after intubation) to ABG done day 2,3 and day 7 |
Safety of TG100-115 for Heart Attack Treated With Angioplasty

Study Overview
=================
Brief Summary
-----------------
TG100-115 is able to reduce the size of heart attacks in pre-clinical models. The hypothesis of this study is that TG100-115 can be given safely to patients who suffer a heart attack and undergo angioplasty to restore blood flow. We will also evaluate whether TG100-115 reduces heart muscle damage.

Official Title
-----------------
A Phase 1-2, Multicenter, Randomized, Double-Blind, Placebo Controlled, Prospective Study to Evaluate the Safety and Potential Efficacy of Single, Increasing Doses of TG100-115 in Subjects Undergoing Percutaneous Coronary Intervention for Acute Anterior ST Elevation Myocardial Infarction

Conditions
-----------------
Myocardial Infarction

Intervention / Treatment
-----------------
* Drug: TG100-115


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18-80 yrs ECG patterns consistent with an acute anterior myocardial infarction with ST segment elevation of 2mm in two contiguous ECG leads among leads V1-V4. Have prolonged, continuous (lasting at least 20 mins) signs and symptoms of myocardial ischemia not eliminated with nitrates. Intent to proceed to primary PCI within 6 hours of chest pain onset Sign an informed consent form and be willing to attend follow-up visits for safety and other study assessments. Exclusion Criteria: Female of childbearing potential. History of previous myocardial infarction. History of congestive heart failure. Requirement for a cardiac pacemaker or defibrillator. Cardiogenic shock. Patients previously treated with thrombolytic therapy. Myocardial ischemia precipitated by a condition other than atherosclerotic coronary artery disease.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: TG100-115|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety and pharmacokinetics of TG100-115 |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Impact of TG100-115 on infarct size |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
myocardial infarction, infarct size, angioplasty, percutaneous coronary intervention, Acute Myocardial Infarction