Effects of Blood Flow Restriction During Eccentric Resistance Exercise

Study Overview
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Brief Summary
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The purpose of this study is to compare the muscle strength and muscle soreness effects experienced following short term (acute) eccentric exercise with and without blood flow restriction (BFR) performed at low - moderate training intensities.

Official Title
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Effects of Blood Flow Restriction During Multiple-joint Eccentric Resistance Training on Muscle Morphology and Function of the Lower Body

Conditions
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Blood Flow Restriction

Intervention / Treatment
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* Device: Eccentric exercise / Eccentric exercise with blood flow restriction


Participation Criteria
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Eligibility Criteria
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Exclusion Criteria: lower body surgery or injury in the last 12 months have any neuromuscular disease height >76 inches tall height <54 inches tall eccentric strength greater than 725 pounds pregnant or plan to be pregnant in the duration of the protocol don't do resistance exercise at least once per week perform intense cardio or strength training >4 days per week Present with any other significant comorbid conditions that would impair the ability to participate in the exercise-based testing Inclusion criteria: 18 - 30 years old strength train lower body 1-3 times per week

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Individuals will be randomly assigned to a BFR or non BFR exercise condition. The subjects will perform a single, 3-5 minute bout of eccentric exercise on the Eccentron device either with BFR (with restriction cuffs on the thigh per the procedures below) or without the BFR.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Eccentric exercise<br>Only multi-joint eccentric exercise | Device: Eccentric exercise / Eccentric exercise with blood flow restriction<br>* Individuals will be randomized to receive eccentric exercise only, or eccentric exercise with blood flow restriction.<br>|
| Experimental: Eccentric training with blood flow restriction<br>Multi-joint eccentric exercise with blood flow restriction | Device: Eccentric exercise / Eccentric exercise with blood flow restriction<br>* Individuals will be randomized to receive eccentric exercise only, or eccentric exercise with blood flow restriction.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| visual analog scale (soreness) | soreness | Baseline (pretest) | 
| visual analog scale (soreness) | soreness | immediately post exercise | 
| visual analog scale (soreness) | soreness | 24 hours post exercise | 
| visual analog scale (soreness) | soreness | 48 hours post exercise | 
| visual analog scale (soreness) | soreness | 72 hours post exercise | 
| force algometer (soreness) | soreness | Baseline (pretest) | 
| force algometer (soreness) | soreness | immediately post exercise | 
| force algometer (soreness) | soreness | 24 hours post exercise | 
| force algometer (soreness) | soreness | 48 hours post exercise | 
| force algometer (soreness) | soreness | 72 hours post exercise | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Eccentric muscle strength | muscle strength will be assessed on the Eccentron. | Baseline (pretest) | 
| Eccentric muscle strength | muscle strength will be assessed on the Eccentron. | immediately post exercise | 
| Eccentric muscle strength | muscle strength will be assessed on the Eccentron. | 24 hours post exercise | 
| Eccentric muscle strength | muscle strength will be assessed on the Eccentron. | 48 hours post exercise | 
| Eccentric muscle strength | muscle strength will be assessed on the Eccentron. | 72 hours post exercise | 
| Single-leg hop | 3 single-leg hops per limb | Baseline (pretest) | 
| Single-leg hop | 3 single-leg hops per limb | immediately post exercise | 
| Single-leg hop | 3 single-leg hops per limb | 24 hours post exercise | 
| Single-leg hop | 3 single-leg hops per limb | 48 hours post exercise | 
| Single-leg hop | 3 single-leg hops per limb | 72 hours post exercise |