Left Elective Colectomy in Renal Transplanted Patients

Study Overview
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Brief Summary
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Aim of the study : To evaluate postoperative outcomes of elective left-sided colectomy in a renal transplanted population. Methods : From 2010 to 2015, all consecutive patients who underwent left elective colectomy in a referral center were prospectively collected. Considering our exclusion criterial, data from 120 patients were analyzed. The cohort was separated into 2 groups : renal transplanted patients (KTR-group) and non-renal transplanted patients (C-group) Short and longterm outcomes were compared between the two groups. Primary outcome : 90 days postoperative anastomotic leak rate

Detailed Description
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From January 2010 to December 2015, data from patients requiring an elective left colectomy for benign or malignant indication were collected prospectively in our colorectal surgery database. According to our exclusion criterial patients were retrospectively divided into two groups: kidney transplant recipients (KTR-group) and control group (C-group). The surgical indication for an oncologic left colectomy was retained by the expert surgeon, after a multidisciplinary conversation meeting comprising at least one surgeon, one gastroenterologist, one nephrologist, one radiologist and one oncologist. The surgical indication for diverticular disease was based on French guidelines. Demographic, clinical, intraoperative and postoperative, histological, length of hospital stay and mortality data were collected over a 90-day period following the intervention.

Official Title
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Left Elective Colectomy in Renal Transplanted Patients : a Case-control Study (LECoRT Study)

Conditions
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Left Elective Colectomy, Renal Transplanted Patients

Intervention / Treatment
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* Procedure: Left elective colectomy


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Open or laparoscopic left elective colectomy with colo-rectal anastomosis age > 18 y.o. Exclusion criteria: emergency surgery past history of rectal surgery ASA I

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group 1 (Kidney transplanted patients)<br>Group 1: Kidney transplanted patients requiring oncologic or non-oncologic left elective colectomy All kidney transplanted patients requiring oncologic or non-oncologic left elective colectomy between 01 January 2004 and 31 December 2015. | Procedure: Left elective colectomy<br>* Open or laparoscopic left elective colectomy with colo-rectal anastomosis<br>|
| Group 2 (Non-transplanted patients)<br>Group 2 : Non-transplanted patients requiring oncologic or non-oncologic left elective colectomy Non-transplanted patients requiring oncologic or non-oncologic left elective colectomy between 01 January 2004 and 31 December 2015. | Procedure: Left elective colectomy<br>* Open or laparoscopic left elective colectomy with colo-rectal anastomosis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of Anastomotic leak after left elective colectomy | Anastomotic leak according to the International Study Group of Rectal Cancer | 90 days postoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Long term outcomes | Status at the date of latest news | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Benign or malign pathology, Renal transplanted patients, Anastomotic leakage