Remifentanil for Smooth Emergence in Elderly Patients

Study Overview
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Brief Summary
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Elderly patients show different pharmacokinetic and pharmacodynamic variables and usually need smaller doses of anaesthetic drugs than younger patients. The purpose of this study was to investigate the optimal effect-site concentration of remifentanil for preventing cough during emergence in elderly patients under sevoflurane and remifentanil anesthesia.

Official Title
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Effect-site Concentration of Remifentanil for Preventing Cough During Emergence in Elderly Patients

Conditions
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Drug Usage

Intervention / Treatment
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* Drug: Remifentanil
* Drug: Remifentanil
* Drug: Sevoflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA physical status I or II undergoing endoscopic sinus surgery or septoplasty under balanced anesthesia with sevoflurane and remifentanil Exclusion Criteria: predicted difficult airway, body mass index > 30 kg/m2, history of obstructive sleep apnoea chronic respiratory disease or coughing, current smokers patients angiotensin converting enzyme-inhibitors

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Elderly<br>Remifentanil was maintained at predetermined effect-site concentration during the emergence period in elderly patients. | Drug: Remifentanil<br>* Remifentanil was maintained at predetermined effect-site concentration during the periextubation period (initial concentration: 1.8 ng/ml) in adult patients (20-60 years) .<br>* Other names: Ultiva;Drug: Sevoflurane<br>* Anesthesia was maintained with sevoflurane with 1.5-2.0 vol% in air/50%oxygen mixture, and sevoflurane was adjusted to about 1.0 vol% 10 min before end of surgery.<br>|
| Active Comparator: Adult<br>Remifentanil was maintained at predetermined effect-site concentration during the emergence period in adult patients. | Drug: Remifentanil<br>* Remifentanil was maintained at predetermined effect-site concentration during the periextubation period (initial concentration: 1.8 ng/ml) in elderly patients (65-80 years) .<br>* Other names: Ultiva;Drug: Sevoflurane<br>* Anesthesia was maintained with sevoflurane with 1.5-2.0 vol% in air/50%oxygen mixture, and sevoflurane was adjusted to about 1.0 vol% 10 min before end of surgery.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of cough | Number of cough or a strong and sudden contraction of the abdomen during periextubation periods | from end of surgery to 5 min after tracheal extubation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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tracheal extubation, remifentanil