linjc16/ctgov huggingface dataset:
Combi-elastography Assessment of HCC Recurrence After Thermal Ablation Multi-center Study

Study Overview
=================
Brief Summary
-----------------
Combined F index, A index,ATT index and spleen stiffness to predict tumor recurrence in different liver settings after thermal ablation of HCC.

Detailed Description
-----------------
Thermal ablation is one of the established method for HCC treatment. Postoperative recurrence of HCC is one of the major factors leading to poor prognosis of HCC patients. Most studies have shown that the risk factors of recurrence include tumor size, tumor number and intrahepatic spread, etc. Besides, the carcinogenic effects of inflammatory activity and fibrosis in liver background caused by chronic hepatitis also be related to the recurrence. In the study, combi-elastography imaging technology , not only the F index which is related to liver fibrosis stage can be obtained, but also the A index which is related to inflammation activity can be measured, this may provide a more valuable method for tumor recurrence of early prediction.

Official Title
-----------------
Combi-elastography Assessment of HCC Recurrence After Thermal Ablation Multi-center Study

Conditions
-----------------
HCC, Recurrence Tumor

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Aged 18 to 80 years of age, and gender not limited;Chronic hepatitis B patients;The lesions of liver have the histopathological diagnosis of HCC and within MiLan criteria;All lesions were performed thermal ablation surgery;Sign the informed consent. Exclusion Criteria: Lesions that unrealized complete inactivation evaluation by the enhanced imaging;Merging other systems' serious illness that can't cooperate with elastic imaging checking(such as heart failure, renal failure, such as mental illness);After liver transplantation patients;Patients with pregnancy.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| F index | F index is linked to the degree of liver fibrosis,and it can be available by ultrasound elastography checking. | baseline | 
| A index | A index is linked to the degree of hepatitis,and it can be available by ultrasound elastography checking. | baseline | 
| ATT index | ATT index is linked to the degree of steatosis of liver,and it can be available by ultrasound elastography checking. | baseline | 
| Spleen stiffness | Spleen stiffness can be available by ultrasound elastography checking. | baseline | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Thermal ablation, Elastography, Ultrasound, Recurrence, Predictive Cancer Model
Effects of Humidity (During CPAP Treatment) on Mucociliary Clearance in Patients With Obstructive Sleep Apnea

Study Overview
=================
Brief Summary
-----------------
That the level of humidification delivered to patients during CPAP treatment will alter the subjects mucociliary clearance rate and related mucus properties.

Official Title
-----------------
Effects of nCPAP With and Without Humidification on: Inspiratory Temperature, Humidity, Saccharine Transit Time, Nasal Lavage and in Vitro Mucus Properties in Patients With Obstructive Sleep Apnea

Conditions
-----------------
Obstructive Sleep Apnea

Intervention / Treatment
-----------------
* Device: CPAP + ThermoSmart™ humidity
* Device: CPAP + Conventional humidity
* Device: CPAP + No added humidity


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Moderate to severe obstructive sleep apnea - Apnea Hypopnea Index (AHI) > 15 75% of events during the diagnostic study must be obstructive Exclusion Criteria: Currently using CPAP treatment OR have used it in the past 4 weeks Intolerance of CPAP and/or CPAP mask in the past or during the titration night Mouth breather (unable to breath through mouth for the study period) < 18years old Nasal CPAP intolerance determined in the PSG-CPAP titration study Serious nasal issues Acute upper airway disease Smoker COPD Congestive heart failure Neuromuscular disease Stroke

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: CPAP + ThermoSmart™ humidity<br> | Device: CPAP + ThermoSmart™ humidity<br>* an absolute humidity (AH) of 28 mg/l +/- 2mg/l<br>|
| Active Comparator: CPAP + Conventional humidity<br> | Device: CPAP + Conventional humidity<br>* an absolute humidity (AH) of 18 mg/l +/- 2 mg/l<br>|
| Active Comparator: CPAP + No added humidity<br> | Device: CPAP + No added humidity<br>* ambient humidity<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mucociliary clearance. |  | pre and post cpap treatment with varying levels of humidity |
Evaluation of Two Type III GBS Polysaccharide-Tetanus Toxoid Conjugate Vaccines

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to test the safety and favorable immune response to an anti-streptococcal vaccine (a vaccine that treats a common bacterial infection) in healthy non-pregnant women. Group B Streptococcus (GBS) continues to be the single most frequent cause of life-threatening bacterial infection during the first 2 months of life. Further, GBS pregnancy-related morbidity afflicts more than 50,000 women annually in the US. Therefore, active immunization of women is an appealing strategy for the prevention of GBS disease in pregnant women and their infants during the first 3 months of infant life.

Detailed Description
-----------------
In this study 65 healthy, non-pregnant women will receive a single dose of one of two anti-streptococcal vaccinations. Both types of vaccinations are given in upper arm by injection into the muscle. To assess the vaccine effectiveness, patients have blood drawn and examined at weeks 4, 8 and 26, post-vaccination.

Official Title
-----------------
Evaluation of Two Type III GBS Polysaccharide-Tetanus Toxoid Conjugate Vaccines

Conditions
-----------------
Bacterial Infections, Group B Streptococcus

Intervention / Treatment
-----------------
* Biological: GBS III-TT-SSI
* Biological: GBS III-TT-MPHL


Participation Criteria
=================
Eligibility Criteria
-----------------
This information currently is not available.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: GBS III-TT-SSI|nan|
|Biological: GBS III-TT-MPHL|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Clinical Evaluation
Patient Satisfaction in Post-LASIK Patients With Presbyopia-Correcting IOLs vs. Post-Lasik Patients With Monofocal IOLs

Study Overview
=================
Brief Summary
-----------------
Compare functional visual outcomes and patient satisfaction of post-LASIK patients having received presbyopia-correcting IOLs versus post-LASIK patients having received monofocal IOLs

Official Title
-----------------
Multivariate Regression Analysis of Patient Satisfaction in Post-LASIK Patients With Presbyopia-Correcting IOLs vs. Post-LASIK Patients With Monofocal IOLs

Conditions
-----------------
Patient Satisfaction

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Post-LASIK Post cataract surgery Implantation of ZLB00, ZXR or ZXT, ZCB00, or AO60 intraocular lenses Spherical values greater than ± 0.50 and/or cylinder magnitude greater than 0.75D Exclusion Criteria: Any vision-limiting problems (e.g., corneal, retinal, infection) which could potentially limit their post-operative visual potential Any newly acquired ocular condition or pathology (e.g., ARMD, epiretinal membrane, chronic dry eye, irregular astigmatism, diabetic retinopathy) Max sphere no greater than ± 0.50D and cylinder less than and/or equal to 0.75D
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Extended Depth of Focus IOL<br>Post-LASIK patients with implantation of a presbyopia-correcting IOL | |
| Monofocal IOL<br>Post-LASIK patients with implantation of a monofocal IOL | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patient Satisfaction: subjective questionnaire | Subjective questionnaire explores the frequency and need for glasses for various visual functions at distance, intermediate, and near and overall satisfaction of visual function without glasses | Measured 3 months to 4 years after cataract surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual Acuity at Distance | Uncorrected and best corrected visual acuities measured at distance | Measured 3 months to 4 years after cataract surgery | 
| Visual Acuity at Intermediate | Uncorrected and best corrected visual acuities measured at intermediate | Measured 3 months to 4 years after cataract surgery | 
| Visual Acuity at Near | Uncorrected and best corrected visual acuities measured at near | Measured 3 months to 4 years; after cataract surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Post-LASIK, Presbyopia-correcting IOL, Monofocal IOL
Medullary Colonic Carcinoma

Study Overview
=================
Brief Summary
-----------------
Retrospective cohort of 10 cases of colonic adenocarcinoma of medullary type, operated between 2000 and 2020 at the University Hospital of Limoges. Collection of relevant data for this rare entity. Subgroup analysis in search of prognostic factors. Comparison of the data from our cohort with those from the literature.

Detailed Description
-----------------
Colorectal cancer (CRC) is the third most common cancer in the world after breast and prostate cancer (1). It is also the second most common cause of cancer death in France (2). Most CRCs are adenocarcinomas. However, there is a distinct subtype of adenocarcinoma of relatively recent recognition, called medullary carcinomas (MC). Its recent recognition as a distinct entity (3) has made it difficult to study the epidemiologic characteristics of this cancer, with little population-based data. The largest cohort studied in the literature is from a US sample of 74 patients seen between 1973 and 2006 (4). The main objective of this French retrospective study is to highlight some common features in this group of patients with medullary colorectal cancers, thus improving our knowledge of this cancer subtype and in particular its prognosis. Medullary colorectal cancer is a type of cancer with a prognosis of its own, probably different from the most common histological entity, colorectal adenocarcinoma. This is a retrospective study a cohort of 10 cases of colonic adenocarcinoma of medullary type, operated between 2000 and 2020 at the University Hospital of Limoges. A collection of relevant data was realised for the subgroup analysis in search of prognostic factors for this rare entity as well as a comparison of the data from this cohort with those from the literature.

Official Title
-----------------
Medullary Colonic Carcinoma

Conditions
-----------------
Medullary Carcinoma of Colon, Prognostic Factors, Survival Analysis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pathological diagnosis of colorectal adenocarcinoma of medullary type between 2000 and 2020 Exclusion Criteria: Absence of anatomopathological confirmation on the surgical specimen
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival | Number of days between diagnosis and death | Through study completion in April 2021 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression | Number of days between first surgery and appearance of metastases | Through study completion in April 2021 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Medullary Carcinoma of Colon, prognostic factors, survival analysis
A Controlled Study of Quality of Life and it's Related Factors Among Gynecological Cancer Survivors

Study Overview
=================
Brief Summary
-----------------
To compare quality of life and it's related factors between gynecological cancer survivor and healthy controls.

Detailed Description
-----------------
This study used a cross-sectional design. By using the method of purposive sampling, the 70 gynecological cancer patients who had completed the active treatments for six months will be recruited from the oncology and gynecology clinics of a medical center in the Northern Taiwan area. The 70 healthy controls without any cancer will be recruited from clinic and from friends and colleagues. The instruments include Sample characteristics questionnaire, Short Form-12 (SF-12), Medical Outcome Study Sleep Scale (MOS-sleep), Beck Depression Inventory-II (BDI), State-Trait Anxiety Inventory (STAI), Sexual Activity Questionnaire (SAQ), and The Experiences in Close Relationships-Revised (ECR-R). The data will be analyzed by descriptive statistical analysis, independent t-test, ANOVA, Scheffe's test, Pearson's correlation, and stepwise regression.

Official Title
-----------------
A Controlled Study of Quality of Life and it's Related Factors Among Gynecological Cancer Survivors

Conditions
-----------------
Cervical Cancer, Ovarian Cancer, Endometrial Cancer

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Been diagnosed as cervical cancer, ovarian cancer or endometrial cancer, and has completed six months after the relevant treatment. 20-70 years old Agreed to participate in this study. Exclusion Criteria: Combined with other non-gynecologic cancer (cervical cancer, ovarian cancer or endometrial cancer) patients.

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| gynecological cancer survivors<br>Criteria for including: (1)Been diagnosed as cervical cancer, ovarian cancer or endometrial cancer, and has completed six months after the relevant treatment. (2)Age from 20 - 70 years old. (3) Agreed to participate in this study. Criteria for exclusion: Combined with other non-gynecologic cancer (cervical cancer, ovarian cancer or endometrial cancer) patients. | |
| healthy controls<br>Criteria for including: (1)Not those who suffer from cancer.(2)20-70 years old.(3)Agreed to participate in this study.Criteria for exclusion:Had undergone gynecologic surgical removal of ovaries or uterus were. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
gynecological cancer survivors, quality of life
Secondary Prevention Treatment in Patients Who Have Suffered a Cardiovascular Event

Study Overview
=================
Brief Summary
-----------------
AstraZeneca was interested in knowing how Cardiologists and Physicians treat patients who have suffered a cardiovascular event.

Official Title
-----------------
Secondary Prevention Treatment in Patients Who Have Suffered a Cardiovascular Event.

Conditions
-----------------
Cardiovascular Events

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients who has experienced cardiovascular events Exclusion Criteria: Patients with no cardiovascular events.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Non-Invasive Characterization of Focal Liver Lesions in Liver Cirrhosis

Study Overview
=================
Brief Summary
-----------------
This study aims to analyze non-invasive characterization focal liver lesions in patients with liver cirrhosis. The diagnostic accuracy and predictive value of non-invasive methods is studied.

Detailed Description
-----------------
This study aims to analyze non-invasive characterization focal liver lesions in patients with liver cirrhosis. The diagnostic accuracy and predictive value of non-invasive methods is studied. Upon diagnosis multiparametric ultrasound imaging of the lesions as well as sarcopenia parameters are performed for characterization of the lesions. For primary endpoint the results are then analyzed with regard to diagnostic accuracy compared to gold standard (CT, MRI or histology). For secondary endpoint, predictive value of the non-invasive diagnostics are analyzed with regards to mortality and response to treatment. All work up, treatment and follow up are applied in standard of care fashion.

Official Title
-----------------
Non-Invasive Characterization of Focal Liver Lesions in Liver Cirrhosis

Conditions
-----------------
Liver Cirrhoses

Intervention / Treatment
-----------------
* Diagnostic Test: Standard diagnostic procedures


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all patients with focal liver lesions and liver cirrhosis Exclusion Criteria: no consent under 18 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Diagnostic Test: Standard diagnostic procedures|B-Mode ultrasound, Duplex sonography, contrast-enhanced ultrasound, elastography, CT, MRI, anthropometrics|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diagnostic accuracy | The diagnostic accuracy of non-invasive imaging of focal liver lesions in liver cirrhosis compared to gold standard (histology, CT and/or MRI) | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Predictive Value | The predictive value on mortality and treatment response of non-invasive imaging of focal liver lesions in liver cirrhosis | up to 5 years |
3D Model of Posterior Membranous Labyrinth of the Inner Ear

Study Overview
=================
Brief Summary
-----------------
The aim of this work is to create a three-dimensional (3D) finite element model (FEM) of the human posterior membranous labyrinth, based on in vivo inner ear magnetic resonance imaging (MRI). This model has a pedagogical interest, and can serve as a basis for reflection in cases of atypical benign paroxysmal positional vertigos. It can also serve for mechanical studies of vestibular physiology.

Official Title
-----------------
3D Finite Element Model of Posterior Membranous Labyrinth From in Vivo MRI of Human Temporal Bone

Conditions
-----------------
Reconstruction of the Posterior Membranous Labyrinth

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient aged 18 or over Adult who has performed an imaging of the inner ear Exclusion Criteria: Refusal to participate in the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measure of dimensions of the model to study the validity of the geometry |  | Creation of 3D model: 1 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
3D model, Inner ear