Evaluation of Functions of Swallowing and Voice in Ankylosing Spondylitis Patients

Study Overview
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Brief Summary
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In this study was to determine whether changes that occurred over time had an impact on the swallowing and voice functions depend of Ankylosing spondylitis patients.

Detailed Description
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This study was carried out at the University of Health Sciences Okmeydani Training and Research Hospital, Department of Otorhinolaryngology. Study was performed on 30 patients and 30 healthy subjects (Group 2) who were diagnosed with ankylosing spondylitis using modified New York criterion. The patients were asked to fill the EAT-10 and flexible endoscopic swallowing evaluation was performed. Voice recordings were taken from the patients to evaluate the voice disturbance and acoustic evaluation was taken with PRAAT program.

Official Title
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Evaluation of Functions of Swallowing and Voice in Ankylosing Spondylitis Patients

Conditions
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Ankylosing Spondylitis, Swallowing Disorder.Other Specified, Voice Alteration

Intervention / Treatment
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* Diagnostic Test: flexible endoscopic evaluation of swallowing
* Diagnostic Test: The analysis of voice


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed with Ankylosing spondylitis Person who accept to consent form Exclusion Criteria: Pulmoner diseases Laryngeal polip or nodules Underwent to larynx or esophageal surgery Central nerve system diseases

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Study group<br>Study group was performed on 30 patients who were diagnosed with ankylosing spondylitis using modified New York criterion. | Diagnostic Test: flexible endoscopic evaluation of swallowing<br>* The patients were assessment with flexible endoscopic swallowing evaluation was performed with colored pudding.<br>Diagnostic Test: The analysis of voice<br>* Voice recordings were taken from the patients to evaluate the voice disturbance and acoustic evaluation was taken with PRAAT program.<br>|
| Control group<br>Control group was performed on 30 participants who were healthy. | Diagnostic Test: flexible endoscopic evaluation of swallowing<br>* The patients were assessment with flexible endoscopic swallowing evaluation was performed with colored pudding.<br>Diagnostic Test: The analysis of voice<br>* Voice recordings were taken from the patients to evaluate the voice disturbance and acoustic evaluation was taken with PRAAT program.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of swallowing | Quality of swallowing was assessed by Eating Assessment Tool inventory consisting in 10 questions that scores from 0 to 40. Low score is better, higher score is worse. | 3 months | 
| Values of aspiration | Aspiration was assessed by aspiration penetration scale during swallowing with flexible endoscopy. The scale consisting in 8 degree that scored from 1 to 8. Higher score is worse. | 3 months | 
| Voice analysis | Voice recordings were analyzed by PRAAT computer software. The investigator measured to shimmer, jitter and HNR voice values. The values are variation of frequency and amplitude of the sound wave. Higher value shows healthy voice for HNR parameters, lower value shows healthy voice for shimmer and jitter. | 3 months | 
| Cervical spine situation | Cervical spine was assessed with modify stoke ankylosing spondylitis spine score that scored from 0 to 3. Low score is better and high score is worse. | 3 months | 
| Ankylosing spondylitis disease activity | The investigator measured to disease activity with bath ankylosing spondylitis disease activity index consisting in 6 questions that scored from 0 to 10 and morning rigidity times. Low scores are better and high scores are worse. | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Demographic values | Demographic values were assessed as age (18-70) ,education and gender (male or female). | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ankylosing spondylitis, swallowing, voice