Rubidium-82 Position Emission Computed Tomography (PET) Versus Gated, Rest / Stress Technetium 99-m SPECT

Study Overview
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Brief Summary
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Many stress tests being done today have two parts, the stress test and the pictures of your heart. The investigators are comparing a newer technique to obtain the pictures (PET imaging) to the standard method (SPECT imaging). However, it is not known if the new test is better than the old test. It is important to have a standard to compare these tests to, and that is why people who will be getting a cardiac catheterization are being asked to participate. The information about your arteries from the cardiac catheterization will be used to judge which stress test is better. The investigators hypothesize that the newer method (PET imaging) will be more accurate than the old method (SPECT) in detecting heart disease.

Detailed Description
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A SPECT rest image will be obtained using a technetium based isotope. On a separate day, a Rubidium rest PET image will be obtained prior to a Dipyridamole stress test. Subjects will receive both Rubidium and technetium isotopes following the Dipyridamole stress, and will undergo first PET imaging and later SPECT imaging following the stress test. Patients will then go for cardiac catheterization as clinically ordered by their physician.

Official Title
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A Prospective Comparison of Gated, Rest/Stress Rubidium-82 Position Emission Computed Tomography (PET) vs. Gated, Rest / Stress Technetium 99-m SPECT

Conditions
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Coronary Artery Disease, Myocardial Ischemia, Heart Disease

Intervention / Treatment
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* Other: SPECT imaging
* Other: PET imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: referred for clinical cardiac catheterization Exclusion Criteria: previous CABG previous MI Asthma or obstructive airway disease Intolerance to Dipyridamole Moderate to severe valvular disease Cardiomyopathy - (ejection fraction less than 45%)

Ages Eligible for Study
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Minimum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PET SPECT<br>Subjects will have both types of imaging performed, PET and SPECT | Other: SPECT imaging<br>* Dipyridamole stress testing 0.57 mg/kg<br>* Other names: Persantine stress test;Other: PET imaging<br>* Dipyridamole stress test 0.57 mg/kg with Rubidium PET images<br>* Other names: PET persantine stress test;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Coronary Artery Disease |  | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Myocardial Ischemia |  | 30 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CAD, chest pain, acute coronary syndrome, Myocardial perfusion imaging