Alzheimer's Disease and Physiological, Cognitive Function and BDNF Levels of Plasma Adaptation After Exercise Training

Study Overview
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Brief Summary
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Alzheimer's disease (AD) is a neurodegenerative disease leading to one of the most common forms of dementia in humans and memory disorder is one of the first symptoms that lead to diagnosis.

Detailed Description
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Present in greater amounts in the regions of the hippocampus and cortex, the Brain-derived neurotrophic factor (BDNF) is essential to both learning and memory processes. This protein is found in lower amounts in people with AD. Acute physical activity of moderate to vigorous intensity would increase the levels of plasma BDNF whether for a healthy person or a person with AD. Nevertheless in rest, healthy people have higher level of BDNF than individuals with AD. There are no studies on the effect of chronic exercise based on BDNF level at rest in people with AD. In a hypothetical endurance training of 18 sessions, whether interval or continuous training the levels of BDNF would increase in people with AD at rest. Their physiological and neuropsychological performances would also show a rise.

Official Title
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Alzheimer's Disease and Physiological, Cognitive Function and BDNF Levels of Plasma Adaptation After Exercise Training

Conditions
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Alzheimer's Disease

Intervention / Treatment
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* Device: Endurance Training
* Other: therapeutic education meetings


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Alzheimer's disease patients diagnosed by a consultation memory (DSM- IV) Person with at least 60 years Person with a score higher than 15 in the Mini Mental State Examination No one can achieve the pedaling motion People who do not perform regular physical activity on bike Nobody has given free and informed consent in writing or obtained from a trusted person or the family environment People affiliated to a social security Exclusion Criteria: Patient who refused to provide written consent Inability to pedal Recent myocardial necrosis (less than 3 months) Aortic Stenosis Uncompensated heart failure Unstable angina Ventricular arrythmia Pulmonary embolism Coxarthrosis, knee, ankle osteoarthritis Not affiliated to a social security Patient already participating in another biomedical research

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Endurance Training<br>The first group of 40 people will do endurance training; 20 of them will perform a continuous exercise on cycle ergometer at a power equivalent to 70% of the maximal heart rate, twice a week. The other group will do Interval Training, with a four minute long base and one minute long peak, twice a week. The base workload will be equivalent to an intensity of 60% of the maximal heart rate and the peak will be equivalent to 80% of the maximal heart rate. | Device: Endurance Training<br>* 40 people will submitted to endurance training: 20 will perform a continuous training and 20 will perform an interval training. The variables that will be analyzed are maximum aerobic power, endurance, heart rate, prehension strength, Mini-Mental State Examination (MMSE), REY's test, biological examination and level of BDNF plasma, before and after the intervention and one month after the end of the intervention and one month after the end of the intervention.<br>|
| Active Comparator: Control group<br>20 persons will be in the control group and they will not perform the endurance training. However, they will have 9 therapeutic education meetings. | Other: therapeutic education meetings<br>* Group of 20 people will be the control group and will not perform ET. However, they will have 9 therapeutic education meetings.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measuring the effect of a program of endurance training (ET), on the levels of plasma BDNF. |  | Up to 4 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measuring the effect of training on the psychological performance by using questionnaire MMSE |  | Up to 4 months | 
| Measuring the effect of training on the psychological performance by using questionnaire: Rey auditory verbal learning test (RAVLT) |  | Up to 4 months | 
| Measuring the effect of training on the psychological performance by using questionnaire: quality of life (QoL-AD) |  | Up to 4 months | 
| Stress test | Measuring the effect of training on the physiological performance by determining the maximum power of the effort tolerated | Up to 4 months | 
| Stress test | Measuring the effect of training on the physiological performance by determining the grip strength | Up to 4 months | 
| Measuring the effect of training on the physiological performance with a walk test of 6 minutes. |  | Up to 4 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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endurance training, BDNF analysis, cognitive function, physiological abilities