Efficacy of Drinking Water During Capsule Endoscopy

Study Overview
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Brief Summary
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The aims of this study are to evaluate the effect of early drinking water after the capsule ingestion on the gastrointestinal transit and image quality of capsule endoscopy.

Detailed Description
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Capsule endoscopy has been a significant technologic advancement that has allowed the direct examination of mucosa throughout the entire small intestine in a noninvasive fashion; and it has become the primary technique for imaging the small bowel. However, as imaging time is limited to about 8 hours, a prolonged transit of the capsule endoscope in the stomach may result in an incomplete small bowel transit (i.e. failure of the capsule to reach the cecum). Delayed transit time of stomach may be responsible for the failure of capsule endoscopy to visualize the distal portions of the small bowel, and potentially may result in the inability to identify small-bowel pathology in these areas. Previous study showed that drinking water might improve completion rate of capsule endoscopy. And bowel preparation of clear liquids may improve image quality of small bowel mucosa. The aim of this study was to assess the effect of drinking water on the transit time，completion rate and image quality of capsule endoscopy.

Official Title
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Efficacy of Drinking Water on Transit Time and Complete Examination Rate During Capsule Endoscopy

Conditions
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Capsule Endoscopy

Intervention / Treatment
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* Other: drinking water group
* Other: control group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged 18-80 years undergoing capsule endoscopy Exclusion Criteria: Patients with suspected intestinal obstruction, intestinal diverticulum, stricture or fistula previous gastric or small-bowel surgery pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: drinking water group<br>Patients in this group drink colorless water after capsule ingestion. | Other: drinking water group<br>* Those randomized to drink water group were asked to drink 200 mL colorless water every 10 minutes, starting at the time of capsule ingestion until three times in total.<br>|
| Other: control group<br>Patients in this group don't drink colorless water after capsule ingestion. | Other: control group<br>* Those randomized to control group were asked not to drink extra water after capsule ingestion.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| gastric transit time | the time between the first gastric image and the first duodenal image | 3 months | 
| small-bowel transit time | the imaging time of capsule endoscopy in the small bowel | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| complete examination rate of the small bowel | the percentage of patients with complete examination of the small bowel in each group | 3 months | 
| image quality | The scale was based on the uncovered image area percentage (0, 0%-20%; 1, 20%-40%; 3, 60%-80%; 4, 80%-100%). The image quality was based on the mean of 5-min scores and higher scores mean a better outcome. | 3 months | 
| diagnostic yields | Clinical diagnoses made by the capsule endoscopy were recorded for each patient. | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Capsule endoscopy