Analgesia Nociception Index for Pain Monitoring in Intensive Care Units

Study Overview
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Brief Summary
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The aim of this study is to examine the usability of ANI in patients who will be treated in intensive care unit.

Detailed Description
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The aim of this study is to examine the usability of Analgesia Nociception Index in patients who will be treated in intensive care unit ( a- Cardiovascular b- surgical c- internal diseases), mechanically ventilated and lacking communication. The investigators will examine whether the positive inotropic/vasoconstrictor agents will have any effect on Analgesia Nociception Index.

Official Title
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Analgesia Nociception Index for Pain Monitoring in Intensive Care Units

Conditions
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Stress Related Disorder, Pain, Intensive Care Unit Syndrome

Intervention / Treatment
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* Device: Analgesia Nociception Index (ANI)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Intensive Care Cardiovascular Patients Group 1 - Patients aged from 18 to 80 years, scheduled for elective isolated coronary bypass graft (CABG) for 2-4 vessel disease, without any perioperative complications, and who were postoperatively monitored via the analgesia nociception index in the cardiovascular intensive care will be included. Intensive Care Internal Diseases Group 2 - Patients aged from 18 to 80 years, intubated or tracheostomized, In mechanical ventilation with Pressure-Controlled Ventilation mode, under perfusion neuromuscular blocker, Normothermic, non-cooperative and/or sedated and neuromuscular blocker Intensive Care Patients (Obese) Group 3 - Post Bariatric surgery, over 40 BMI Exclusion Criteria: Intensive Care Cardiovascular Patients Group 1 Patients who required emergency surgery, had significant preoperative chronic pain, had autonomic nervous system anomalies and patients with rhythm will be excluded from the study. Intensive Care Internal Diseases Group 2 Ramsey sedation scale under 5, cooperative, with spontaneous breathing effort and extremity movement, non sinusal cardiac rhythm Intensive Care Patients (Obese) Group 3 - patients under 40 BMI

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Intensive Care Patients (Cardiovascular)<br>Intensive care unit patients, mechanically ventilated and lacking communication. Will examine whether the positive inotropic/vasoconstrictor agents will have any effect on Analgesia Nociception Index. | Device: Analgesia Nociception Index (ANI)<br>* Monitorization of Analgesia Nociception Index in Intensive Care Patients<br>|
| Intensive Care Patients (Internal diseases)<br>Intensive care unit patients, both mechanically ventilated and lacking communication and mechanically ventilated and conscious. Will examine whether the positive inotropic/vasoconstrictor agents will have any effect on Analgesia Nociception Index. | Device: Analgesia Nociception Index (ANI)<br>* Monitorization of Analgesia Nociception Index in Intensive Care Patients<br>|
| Intensive Care Patients (Obese)<br>Intensive care unit patients. Will examine whether the positive inotropic/vasoconstrictor agents will have any effect on Analgesia Nociception Index. | Device: Analgesia Nociception Index (ANI)<br>* Monitorization of Analgesia Nociception Index in Intensive Care Patients<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Analgesia Nociception Index for pain monitorization | The duration between two R waves within heart rate variations (filtering the variations in respiratory cycles). A numeric measure of parasympathetic tonus will be obtained. This variation is between (pΣ) 0 and 100. | 3 Months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Analgesia Nociception Index, Intensive Care Unit, Pain Monitoring