Fertility Study of Women With Chronic Inflammatory Rheumatism

Study Overview
=================
Brief Summary
-----------------
Etiopathogenesis of Chronic inflammatory rheumatisms (CIR) includes genetic, autoimmune and environmental factors. Their impact on the quality of life is important, leading to a sometimes severe disability. Thus they are likely to affect female fertility through several mechanisms, including autoimmune since the association between immunity and fertility has already been demonstrated in other autoimmune diseases. This study wants to evaluate and compare the birth rate between CIR and control group.

Detailed Description
-----------------
Data collection will be carried out using a questionnaire submitted to women in charge of the rheumatology department of the University Hospital of Toulouse and having agreed to participate: women with Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis or Chronic juvenile arthritis for the chronic inflammatory rheumatism group women with a mechanical rheumatic pathology for the control group The primary endpoint was birth rate after spontaneous or induced pregnancy in patients who attempted to procreate, in the CIR group and in the control group.

Official Title
-----------------
Fertility Study of Women With Chronic Inflammatory Rheumatism

Conditions
-----------------
Ankylosing Spondylitis, Chronic Juvenile Arthritis, Arthritis, Psoriatic, Arthritis, Rheumatoid

Intervention / Treatment
-----------------
* Other: Questionnaire about fertility


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient with Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis, Chronic juvenile arthritis, Chronic Inflammatory Rheumatism Patient diagnosed before the age of 40 Patient having given her no opposition to her participation in research For the control group: patient not suffering from chronic inflammatory rheumatism, having consulted in Rheumatology for a mechanical pathology Exclusion Criteria: Patient> 40 years old at the time of diagnosis Patient with insufficient medical data (treatments)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients diagnosed before age 40<br>Patient between 18 and 50 years-old with Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis, Chronic juvenile arthritis, Chronic Inflammatory Rheumatism who will answer to a questionnaire about fertility | Other: Questionnaire about fertility<br>* Sending a questionnaire about fertility that will have to be returned to us in order to be included in the study. The questionnaires, anonymous, will be numbered according to their order of return.<br>|
| Control Group<br>Patient between the ages of 18 and 50 years, not diagnosed with Chronic inflammatory rheumatism, having consulted in Rheumatology for a mechanical pathology, presenting no chronic pathology, having no chemo or radiotherapy or immunosuppressive therapy, or pelvic surgery before age 40 years who will answer to a questionnaire about fertility | Other: Questionnaire about fertility<br>* Sending a questionnaire about fertility that will have to be returned to us in order to be included in the study. The questionnaires, anonymous, will be numbered according to their order of return.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Birth rate after spontaneous or induced pregnancy | Birth rate after spontaneous or induced pregnancy in women who have tried to procreate in the chronic inflammatory rheumatism group and in the control group. | One day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rates of ectopic pregnancy, early or late spontaneous miscarriage | Rates of ectopic pregnancy, early or late spontaneous miscarriage, early or late pregnancy, children born dead, preterm birth in the CIR group and in the control group | one day | 
| Design time | Design time in the CIR group and in the control group | One day | 
| Birth rate according to the treatments used | Birth rate in the CIR group according to the treatments used | One day | 
| Birth rate according to the activity of the disease | Birth rate in the CIR group according to the activity of the disease | One day | 
| Rates of desire for pregnancy | Rates of desire for pregnancy and study of the reasons for this lack of desire for pregnancy in the CIR group and in the control group | One day | 
| Rates of sexual dysfunction | Rates of sexual dysfunction in the CIR group and in the control group | One day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Chronic inflammatory rheumatism, Fertility, Procreation