linjc16/ctgov huggingface dataset:
Study of the Preventable Passage of Patients Over 75 Years of Age to the Emergency Room of the CHRU of Nancy

Study Overview
=================
Brief Summary
-----------------
The adult emergency service of the Nancy CHRU welcomes an average of 135 visits per day. Approximately 18% are patients over 75 years old, among them 45% go home at the end of their care. The mobile geriatric liaison team intervenes with these patients at the request of the emergency doctors before they return home in order to identify their fragility and implement appropriate measures. We wish to know the characteristics of these avoidable passages in order to propose preventive measures upstream of these passages. To do this, we need to know the characteristics of those patients with an avoidable passage.

Official Title
-----------------
Study of the Preventable Passage of Patients Over 75 Years of Age to the Emergency Room of the CHRU of Nancy

Conditions
-----------------
Emergencies Elderly

Intervention / Treatment
-----------------
* Other: no intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age>=75 years old admitted at emergency room between first april 2019 and 30 september 2019 outpatients Exclusion Criteria: inpatients discharged patients patients discharged against medical advice patients brought by police

Ages Eligible for Study
-----------------
Minimum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patient over 75 years of age with an emergency room visit<br>Patients over 75 years of age, with a visit to the emergency department between April 1, 2019 and September 30, 2019, with a non-hospitalization at the end of their visit to the emergency department. | Other: no intervention<br>* no intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| characteristics of preventable passages to the emergency room of the Nancy CHRU in the population over 75 years old |  | the day of the admission at emergency room |
General Anesthesia Combined With Epidural Anesthesia Mitigates the Surgical Stress-related Immunosuppression in Patients With Colorectal Cancer

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to prove whether general anesthesia combined with epidural anesthesia could better maintain body balance of Th1/Th2 and Treg/Th17 compared with general anesthesia, so as to reduce the surgical stress-related immunosuppression, and to improve the prognosis.

Conditions
-----------------
Colorectal Neoplasms

Intervention / Treatment
-----------------
* Procedure: epidural anesthesia
* Procedure: general anesthesia


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with Colorectal Cancer(CRC); subjected to the Fast-Track processing of surgery; between 18 and 75 years old. Exclusion Criteria: American Society of Anesthesiologists(ASA) grade > III; BMI > 30; a history of abdominal surgery, endocrine or immune system dysfunction; recent blood transfusions, hormone or non-steroidal anti-inflammatory therapy during the past month; previous contraindication to epidural anesthesia.

Ages Eligible for Study
-----------------
Minimum Age: 51 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: general anesthesia & epidural anesthesia<br>26 patients received general anesthesia combined with epidural anesthesia for surgery, and patient-controlled epidural analgesia for 2 days after surgery | Procedure: epidural anesthesia<br> <br> Procedure: general anesthesia<br>* Patients received general anesthesia for surgery<br>|
| Experimental: general anesthesia<br>27 patients received general anesthesia for surgery, and patient-controlled intravenous analgesia for 2 days after surgery | Procedure: general anesthesia<br>* Patients received general anesthesia for surgery<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The changes of peripheral immune cells and cytokines | The changes of peripheral subtype of T-helper, myeloid-derived suppressor cells(MDSCs) and cytokines | within the first 5 days after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Anesthesia, T-helper, MDSCs, Colorectal cancer, Fast track
Endoscopic Full Thickness Resection for Gastric GIST

Study Overview
=================
Brief Summary
-----------------
This is a clinical trial to evaluate the efficacy and safety of endoscopic full thickness resection for treatment of gastric GIST

Detailed Description
-----------------
To evaluate the clinical safety and efficacy of endoscopic full thickness resection (EFTR) for treatment of gastric GIST. A total of 30 patients will be recruited

Official Title
-----------------
Prospective Clinical Study on Safety and Effectiveness of Endoscopic Full Thickness Resection for Treatment of Patients With Gastric Gastrointestinal Stromal Tumors (GIST)

Conditions
-----------------
Gastric GIST

Intervention / Treatment
-----------------
* Procedure: Endoscopic Full Thickness Resection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > 18 and ≤ 80 Gastric submucosal tumors located at cardia, lesser curvature and antrum Size of the submucosal tumor between 10mm to 30mm as assessed by endoscopic Exclusion Criteria: Patients who are considered as unfit for general anesthesia ASA class ≥ IV or moribund patients Pregnancy Gastric submucosal tumors located at greater curvature and fundus

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Endoscopic Full Thickness Resection<br>Resection of the gastric GIST by ESD techniques followed by endoscopic closure of defect with suturing or clips and loop | Procedure: Endoscopic Full Thickness Resection<br>* Endoscopic full thickness resection achieved by resecting the submucosal tumor using retraction techniques and submucosal dissection, followed by closure<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complete resection of GIST | Complete resection of the GIST defined by en-bloc resection in one piece by endoscopy with clear resection margins | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adverse event rate | Adverse event as defined by presence of either postoperative bleeding or leakage after closure | 30 days | 
| Perioperative mortality | Death within 30 days after procedure | 30 days | 
| Histolology assessment | Histology outcome as defined by any involvement of the tumor margins after resection | 30 days | 
| Hospital stay | Length of stay in hospital | 30 days | 
| technical success in complete resection | Technical success defined by complete endoscopic resection, closure of the defect and delivery of the specimen per orally without need of conversion to laparoscopic surgery | 1 day |
Post-partum Perineal Pain - Chirocaine®

Study Overview
=================
Brief Summary
-----------------
The aim of this placebo-controlled clinical trial is to assess the effectiveness of the local infiltration of the analgesic Chirocaïne® on perineal pain after episiotomy or first-degree tear. The pain intensity is measured in immediate postpartum period by using a numerical rating scale (NRS) at the following times: H2, H4, H8, H12, H24, H36, H48 during rest, defecation and during activities. The safety of Chirocaïne® and the patient satisfaction are also evaluated at each time.

Official Title
-----------------
Contribution of the Local Infiltration of Chirocaine® in the Management of the Post-partum Perineal Pain After Episiotomy or First-degree Tear

Conditions
-----------------
Post-partum Perineal Pain, Episiotomy, Vaginal Tear

Intervention / Treatment
-----------------
* Drug: Chirocaine
* Other: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Inclusion Criteria: Patients aged 18-45 years Single pregnancy. Vaginal normal birth in cephalic presentation or assisted vaginal delivery by vacuum extractor. Patients having a mediolateral episiotomy or a first-degree perineal tear, epidural analgesia. Patients affiliated to a national insurance scheme Patients who have given their written consent Exclusion Criteria: Patient not speaking, reading, writing French. Multiple pregnancy. Breech delivery or instrumental delivery by forceps or spatula. Intact perineum. No epidural analgesia. Patient who represent contraindication to local anesthetics, severe arterial hypotension. Previous tear requiring sutures.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group A<br>Chirocaine | Drug: Chirocaine<br> <br> |
| Placebo Comparator: Group B<br>Placebo | Other: Placebo<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Post-partum perineal pain measured by a numerical rating scale |  | 8 hours post partum | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Post-partum Perineal pain, Episiotomy, First-degree tear
Sensory Perception After Thoracotomy

Study Overview
=================
Brief Summary
-----------------
The study will investigate characteristics of chronic pain after thoracotomy

Official Title
-----------------
Chronic Pain After Thoracotomy

Conditions
-----------------
Neuropathic Pain, Thoracotomy, Chronic Pain

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Able to understand and give consent Can read Residing in Denmark Exclusion Criteria: Unable to understand the written information in Danish Abuse (Medicine, Drugs, Alcohol) Severe psychiatric Illness Conflicting neurological disease

Ages Eligible for Study
-----------------
Minimum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Painfree<br>Thoracotomy patients without chronic pain | |
| With Pain<br>Thoracotomy patients with chronic pain | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| QST score |  | 1 y | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
persistent pain, neuropathic pain, Thoracotomy, Chronic Pain
Quantitative Sensory Testing of the Lower Lip After Inferior Alveolar Nerve Block, and Evaluation of the Role of the Contra-lateral Inferior Alveolar Nerve

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the contribution of the innervation of the contra-lateral mandibular nerve for the innervation of the lower lip area. The investigators hypothesis is that the sensation of the lower lip is contributed by both mandibular nerves (from both sides of the jaw).

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Procedure: Temporary blocking of mandibular nerve


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Healthy subjects with no systemic diseases, chronic medication, past nerve injury, or sensory complaint. Exclusion Criteria: Hypersensitivity/allergy to local anesthetic materials Systemic diseases, Chronic medication Past nerve injury Congenital or acquired deformity in the lower jaw Past fractures/neoplasm of the lower jaw Past surgery to the lower lip

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Study Group<br> | Procedure: Temporary blocking of mandibular nerve<br>* IM. Lidocaine 2% 7.2ML<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quantitative sensory test | Measurement of sensory conduction of A-beta, A-delta, C-fibers of mandibular nerve, using electronic neurometer. | 15 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Mandibular nerve, Mental nerve, Mandibular incisive nerve, Local anesthesia, None, only healthy subjects will be enrolled in this study
Evaluation of the Signal to Noise Ratio at Various Retinal Layers

Study Overview
=================
Brief Summary
-----------------
Compare the signal to noise ratio of each device at various retinal layers.

Detailed Description
-----------------
Compare the signal to noise ratio of each device (SD OCT and SS OCT) at various retinal layers from the same group of subjects

Official Title
-----------------
Evaluation of the Signal to Noise Ratio at Various Retinal Layers in Spectral Domain Optical Coherence Tomography (SD OCT) Compared to Swept Source Optical Coherence Tomography (SS OCT)

Conditions
-----------------
Healthy Eyes

Intervention / Treatment
-----------------
* Device: 3D OCT-1 Maestro
* Device: DRI OCT Triton


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male or female patients > 18 years old who have full legal capacity to volunteer on the date the informed consent is signed. Subjects who can follow the instructions by the clinical staff at the clinical site, and can attend examinations on the scheduled examination date. Subjects who agree to participate in the study. Exclusion Criteria: History of cataract or ocular surgical procedures that render the cornea opaque or otherwise impact its ability to be imaged using the investigational device. Fixation problems which may prevent obtaining good quality images in either eye.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Normal Eyes<br>Subjects with no known ocular diseases will be imaged on the 3D OCT-1 Maestro and DRI OCT Triton | Device: 3D OCT-1 Maestro<br>* Image acquisition of the posterior surface of the eye<br>Device: DRI OCT Triton<br>* Image acquisition of the posterior surface of the eye<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Signal to noise ratio between SD OCT and SS OCT |  | 5 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
no known ocular pathology
Individual and Family Therapy for Children With Anxiety Disorders

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare three treatments to determine which is most effective in reducing anxiety in children.

Detailed Description
-----------------
Children and their parents will complete a comprehensive diagnostic assessment to determine eligibility. The assessment will include an individual diagnostic interview with the child, interviews with the parents, and written observations of the child from family members and teachers. Participants will then be randomly assigned to receive individual cognitive behavioral therapy (ICBT), family CBT (FCBT), or education/support/attention (ESA) for 5 months. Children in the ICBT group will meet individually with a therapist. In the FCBT and ESA treatment groups, children and their parents will meet weekly with a therapist. At the end of treatment and 1 year following treatment completion, families will complete another assessment to determine the effectiveness of each treatment at reducing short- and long-term anxiety symptoms in their children.

Official Title
-----------------
Child and Family Therapy for Anxiety-Disordered Youth

Conditions
-----------------
Anxiety

Intervention / Treatment
-----------------
* Behavioral: Individual Child CBT
* Behavioral: Family CBT
* Behavioral: Education/Support/Attention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Child with DSM-IV criteria for separation anxiety disorder, social phobia, or generalized anxiety disorder Exclusion Criteria for Child Participants: IQ less than 80 Current use of anti-anxiety or antidepressant medications Psychotic symptoms Child and/or parent is non-English speaking

Ages Eligible for Study
-----------------
Minimum Age: 9 Years
Maximum Age: 13 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Individual Child CBT|nan|
|Behavioral: Family CBT|nan|
|Behavioral: Education/Support/Attention|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
MS PATHS Normative Sub-Study

Study Overview
=================
Brief Summary
-----------------
The primary objective of this study is to determine the normative range of brain volume and brain volume change in healthy control (HC) participants whose age, race, and gender distribution is approximately matched to the age, race, and gender distribution of patients with Multiple Sclerosis (MS) enrolled in Study 888MS001. The secondary objective is to use the results of the primary endpoint to ensure consistency of brain volume measurements across MS PATHS centers.

Official Title
-----------------
Longitudinal Brain Volume Change (and Correlates) in Healthy Control Subjects: A Normative Sub-Study of Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS)

Conditions
-----------------
Healthy Volunteer

Participation Criteria
=================
Eligibility Criteria
-----------------
Key Inclusion Criteria Ability to understand the purpose and risks of the study and provide signed and dated informed consent and authorization to use protected health information in accordance with national and local participant privacy regulations. Key Exclusion Criteria History of human immunodeficiency virus. Confirmed or suspected pregnancy. Diagnosis of migraine requiring medication or any other participant-reported diagnosis of a neurological disease or condition (e.g., stroke, transient ischemic attack, epilepsy, brain infection, brain surgery, prior head injury or concussion, or brain tumor). Any participant-reported diagnosis of an autoimmune disorder (e.g., rheumatoid arthritis, Sjögren's syndrome, scleroderma, or systemic lupus erythematosus). Standard MRI exclusion criteria, including claustrophobia, inability to lay still in the magnet (e.g., tremor), or any type of implanted metal in the body that would be affected by the strong magnetic field. NOTE: Other protocol defined Inclusion/Exclusion criteria may apply

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brain volume | Measured by using magnetic resonance imaging (MRI) scans | Every 12 months up to 3 years | 
| Brain volume change | Measured by using MRI scans | Every 12 months up to 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Development of models to calibrate brain volume measurements between centers, if necessary | Measured by using MRI scans | Up to 3 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Imaging research