Fetuin-A as a Marker in Obesity and Type 2 Diabetes Mellitus

Study Overview
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Brief Summary
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The aim of this study is to assess the significance of serum fetuin-A as a marker of obesity and type 2 diabetes mellitus. We used multiple statistical approaches to determine that the fetuin-A level is correlated to body mass index (BMI) as well as random blood sugar in type 2 diabetic patients. Also, we found that there is a Positive correlation between the serum fetuin-A levels and the level of glycosylated hemoglobin (HbA1c) in diabetic patients.

Detailed Description
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The study was a case-control study. We started the study to be performed on eighty subjects divided into four groups: The first group: include twenty subjects with type 2 diabetes mellitus The second group: include twenty obese subjects whose body mass index is 30 or over The third group: include twenty obese subjects with type 2 diabetes mellitus The fourth group includes twenty apparently healthy subjects as control. In this study, we concluded that: Serum fetuin-A can be used as a biomarker and independent risk factor and marker for diagnosis of DM and DM has a detrimental effect on serum fetuin-A fetuin-A could be of relevance for the development of insulin resistance Higher fetuin-A concentrations were associated with type 2 diabetes and insulin resistance Increased serum fetuin-A levels constitute an independent marker of lipid profile. fetuin-A may play a role in the pathogenesis of T2DM. The inhibition of insulin receptor by fetuin-A may lead to increased lipolysis and efflux of free fatty acids from adipose tissue. This could explain associated dyslipidemia observed in type 2 diabetic patients in the present study. Finally, our finding that high plasma fetuin-A levels predict the incidence of type 2 diabetes independently of other established risk factors supports the hypothesis that fetuin-A may play a role in the development of type 2 diabetes.

Official Title
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Study of Using Serum Fetuin-A as a Marker in Obesity and Type 2 Diabetes Mellitus

Conditions
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Diabete Type 2

Intervention / Treatment
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* Diagnostic Test: Serum Level Of Fetuin A


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: • The study included obese and type 2 diabetic patients aged 45-60 years old. and control healthy adult persons Exclusion Criteria: • Cardiac disease and Hypertensive disease Respiratory disease Renal disease GIT and Liver disease Rheumatologic disease Blood disease Endocrine disease except for type 2 diabetes mellitus All with a specific therapeutic drug history.

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| The first group<br>Include One hundred patients with type 2 diabetes mellitus with average body mass index. | Diagnostic Test: Serum Level Of Fetuin A<br> <br> |
| The second group<br>Include One hundred patients whose body mass index is 30 or over without diabetes. | Diagnostic Test: Serum Level Of Fetuin A<br> <br> |
| The third group<br>Include One hundred type 2 diabetic obese patients whose body mass index is 30 or over. | Diagnostic Test: Serum Level Of Fetuin A<br> <br> |
| The fourth group<br>Include One hundred apparently healthy adult person as a control. | Diagnostic Test: Serum Level Of Fetuin A<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 1- Study of human serum fetuin-A and whether it is involved in insulin resistance | 2- To assess the significance of serum fetuin-A as a marker in obesity and type 2 diabetes mellitus | Baesline |