linjc16/ctgov huggingface dataset:
Plexus Brachialis Block. Better to do by Start Than by End of Surgery?

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to find out if the timing of brachial plexus block, before or after surgery, has an impact of the extent of acute postoperative surgical pain or the incidence and severity of long-lasting (chronic) pain after surgery. This is a prospective, randomized, double blind study in patients with radial fractures undergoing surgery with volar plate. The patients will be followed up for 6 months after surgery.

Official Title
-----------------
Plexus Brachialis Block. Better to do by Start Than by End of Surgery?

Conditions
-----------------
Pain

Intervention / Treatment
-----------------
* Procedure: Plexus brachialis block


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Radial fracture ASA 1 and 2 Able to communicate in norwegian Suitable for surgery in general anaesthesia and brachial plexus block Exclusion Criteria: Pregnancy Chronic pain BMI over 35

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Plexus before surgery<br>Plexus brachialis before surgery | Procedure: Plexus brachialis block<br> <br> * Other names: LSIB. Ropivacain 7,5 mg/ml, 0,5 ml/kg;|
| Other: Plexus after surgery<br>Plexus brachialis performed after surgery | Procedure: Plexus brachialis block<br> <br> * Other names: LSIB. Ropivacain 7,5 mg/ml, 0,5 ml/kg;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain | NAS | postoperative to 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pain
Methadone in Pediatric Anesthesia

Study Overview
=================
Brief Summary
-----------------
This study will determine the pharmacokinetics of intravenous (IV) methadone in children undergoing surgery.

Official Title
-----------------
Methadone in Pediatric Anesthesia

Conditions
-----------------
Anesthesia

Intervention / Treatment
-----------------
* Drug: Methadone 0.1mg/kg
* Drug: Methadone 0.2mg/kg
* Drug: Methadone 0.3mg/kg
* Drug: Control


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 5-18 Undergoing General anesthesia and surgery with anticipated postoperative inpatient stay of greater than or equal to 3 days Signed, written, informed consent from legal guardians and assent from patient Exclusion Criteria: History of or known liver or kidney disease

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Methadone 0.1mg/kg<br>Methadone 0.1mg/kg | Drug: Methadone 0.1mg/kg<br>* Subjects will receive methadone as their intraoperative opioid.<br>|
| Experimental: Methadone 0.2mg/kg<br>Methadone 0.2mg/kg | Drug: Methadone 0.2mg/kg<br>* Subjects will receive methadone as their intraoperative opioid.<br>|
| Experimental: Methadone 0.3mg/kg<br>Methadone 0.3mg/kg | Drug: Methadone 0.3mg/kg<br>* Subjects will receive methadone as their intraoperative opioid.<br>|
| Placebo Comparator: Control<br>No methadone | Drug: Methadone 0.2mg/kg<br>* Subjects will receive methadone as their intraoperative opioid.<br>Drug: Control<br>* Subjects will not receive methadone as their intraoperative opioid.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| R-methadone Plasma AUC 0-96hr/Dose |  | 96 hr | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pediatric patients undergoing surgery
Rabies Treatment by Exposure of Patient to X-Ray

Study Overview
=================
Brief Summary
-----------------
x-ray has been proven to kill Rabies virus in vitro, so the investigators can use it in treatment of rabies infected patients.

Detailed Description
-----------------
x-ray has been proven to kill Rabies virus in vitro, so the investigators can use it in treatment of rabies infected patients. this can be done by exposure of infected , manifested patient who didn't receive prophylaxis or delayed in receiving immunoglobulins . also can be applied to patients who have the injury in upper body near the CNS.. it's just an idea and the investigators need help to approve its effect and the investigators believe it will really work and give a new, rapid , cheap and very effective treatment to a 100% fatal disease.. the investigator also predict good results when x ray applied to some localized infections beside its current lines of treatment..

Official Title
-----------------
Effect of X-ray on Rabies Virus in Vivo

Conditions
-----------------
Treatment of Rabies

Intervention / Treatment
-----------------
* Radiation: x ray exposure


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patient bitten by rabid animal with signs and symptoms Exclusion Criteria: bitten by non rabid animal
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: rabies patient 1<br>not received immunoglobulins and symptomatic | Radiation: x ray exposure<br>* exposure of whole body to x ray<br>|
| Experimental: rabies patient 2<br>received immunoglobulins and symptomatic | Radiation: x ray exposure<br>* exposure of whole body to x ray<br>|
| Experimental: rabies patient 3<br>not received immunoglobulins and not yet symptomatic | Radiation: x ray exposure<br>* exposure of whole body to x ray<br>|
| Experimental: rabies patient 4<br>received immunoglobulins and not symptomatic | Radiation: x ray exposure<br>* exposure of whole body to x ray<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the number of rabies infected, symptomatic patients who survived after x-ray exposure | detecting effect of x-ray exposure on treating Rabies | 7 month |
Sodium Bicarbonate Versus Saline for the Prevention of Contrast-induced Nephropathy

Study Overview
=================
Brief Summary
-----------------
Contrast-induced nephrophaty (CIN) accounts for more than 10% of hospital-acquired renal failure. Hydration with sodium bicarbonate is more protective than isotonic saline in animals. Limited data are available in humans. We compared the efficacy of sodium bicarbonate versus isotonic saline to prevent CIN in a large population of patients with renal dysfunction undergoing coronary angiography or intervention.

Official Title
-----------------
Sodium Bicarbonate Versus Saline for the Prevention of Contrast-induced Nephropathy in Patients Undergoing Coronary Angiography

Conditions
-----------------
Contrast-Induced Nephropathy

Intervention / Treatment
-----------------
* Drug: Sodium Bicarbonate
* Drug: Isotonic Saline


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with creatinine clearance < 60 mL/min Exclusion Criteria: contrast medium administration within the previous 10 days end-stage renal failure requiring dialysis refusal to give informed consent
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: A<br>Bicarbonate | Drug: Sodium Bicarbonate<br>* Patients in the sodium bicarbonate group (154 mEq/L) received 3 ml/kg for 1 hour before contrast medium, followed by an infusion of 1 ml/kg/h for 6 hours after the procedure<br>|
| Active Comparator: B<br>Saline | Drug: Isotonic Saline<br>* Patients assigned to the isotonic saline group received 1 ml/kg/h 0.9% sodium chloride for 12 hours before and after the procedure<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Contrast-induced nephrophaty, Contrast media, Angiography, Coronary percutaneous intervention
Adenotonsillectomy and Obstructive Sleep Apnea Study

Study Overview
=================
Brief Summary
-----------------
Adenotonsillectomies are one of the most common childhood surgeries and are first-line treatment to correct childhood obstructive sleep apnea syndrome (OSAS). This is a study comparing patients with and without OSA looking at the length of stay following adenotonsillectomy and the factors affecting length of stay.

Official Title
-----------------
Factors That Increase Length of Stay After Outpatient Surgery of 3-6 Year Olds With OSAS Symptoms Versus Without OSAS Symptoms After Adenotonsillectomy

Conditions
-----------------
Adenotonsillectomy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: history of snoring/gasping/ or pause in breathing reported by caregivers. age 3-6 years old undergoing adenotonsillectomy only no concurrent surgery scheduled as outpatient and plan for discharge home Exclusion Criteria: Preoperatively requiring additional respiratory support scheduled for concurrent surgery that could increase total general anesthetic time recurrent adenotonsillitis as sole indication for surgery

Ages Eligible for Study
-----------------
Minimum Age: 3 Years
Maximum Age: 6 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| OSAS group<br> | |
| Non-OSAS group<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Length of stay (LOS) |  | 1 Day (Day of Surgery) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cause of increased Length of stay (LOS) |  | 1 Day (Day of Surgery) |
Primary Wound Closure Using a Limberg Flap Versus Secondary Wound Healing Following Pilonidal Sinus Excision

Study Overview
=================
Brief Summary
-----------------
To compare primary wound closure using a limberg flap with secondary (p.s.) wound healing following excision of a pilonidal sinus.

Detailed Description
-----------------
Patients who gave their informed consent who had excision of pilonidal sinus were randomly assigned to group A (primary wound closure with a Limberg flap) or to group B (open wound and p.s.wound healing).

Official Title
-----------------
Primary Wound Closure Using a Limberg Flap Versus Secondary Wound Healing Following Pilonidal Sinus Excision: Short-term Results of a Randomized Controlled Multicenter Trial

Conditions
-----------------
Pilonidal Sinus

Intervention / Treatment
-----------------
* Procedure: secondary wound healing
* Procedure: primary wound closure using a limberg flap


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: indication for excision of pilonidal sinus given Exclusion Criteria: limberg flap not possible for surgical reasons

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: limberg flap<br>primary wound closure using a limberg flap | Procedure: primary wound closure using a limberg flap<br>* primary wound closure using a limberg flap<br>|
| Active Comparator: secondary wound healing<br>secondary wound healing | Procedure: secondary wound healing<br>* secondary wound healing<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Inability to work | change for capacity for work at one year post-OP | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain perioperatively and after 3 weeks |  | 0 and 3 weeks | 
| Complication rate after 3 weeks |  | 3 weeks | 
| Patient satisfaction after 3 weeks & 1year |  | 3 weeks and 1 year | 
| Recurrence rate after 1 year |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pilonidal sinus, excision, primary wound closure, limberg flap
One Step Nucleic Acid Amplification in Endobronchial Ultrasound-guided Needle Aspiration Samples

Study Overview
=================
Brief Summary
-----------------
The aim of our study is to investigate if CK19 mRNA-detection via OSNA can accurately detect lymph node metastases in lung cancer patients using EBUS-TBNA samples.

Detailed Description
-----------------
Regional lymph nodes are assessed before tumor resection and before initiation of chemo- or radiotherapy. Endobronchial ultrasound-guided needle aspiration (EBUS-TBNA) is a well-established method for mediastinal and hilar lymph node staging [2, 3]. Samples obtained via this route are much smaller than surgical lymph node biopsies, yet they are able to provide complete and thorough evaluation, this includes current molecular testing. One Step Nucleic Acid Amplification (OSNA), a molecular test that utilizes CK 19 mRNA-concentration as a target marker is becoming a rapidly dynamic method in quick detection of sentinel lymph node (SLN) metastases in breast cancer, colon cancer and other cancers. In lung cancer, the role of SLN is not well established. However, recent publications suggest an accurate and rapid detection of lymph node metastases in NSCLC. However this requires complete lymph node dissection either with mediastinoscopy or by other surgical means such as thoracotomy. The aim of our study is to investigate if CK19 mRNA-detection via OSNA can accurately detect lymph node metastases in lung cancer patients using EBUS-TBNA samples.

Official Title
-----------------
A Molecular Test for Rapid On-site Evaluation in EBUS-TBNAsamples of Lung Cancer Patients

Conditions
-----------------
Lung Neoplasms

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: CT-scan suspicious for lung cancer, enlarged mediastinal lymph nodes (>10 mm), EBUS-TBNA to be performed, age: 18-99 years Exclusion Criteria: age: <18 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 95 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| One step nucleic acid amplification of Cytokeratin 19 mRNA | One step nucleic acid amplification of Cytokeratin 19 mRNA, copy number detection | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
NSCLC, SCLC, lung cancer, EBUS-TBNA
Evaluation of the Use of the GenXpert to Detect Hepatitis C RNA

Study Overview
=================
Brief Summary
-----------------
The results of the GX device are equivalent to standard venous blood sampling. With this study we are going to determine the prevalence in drug users with difficult venous access. On the other hand, we want to look at the place this device can have in primary care.

Official Title
-----------------
Evaluation of the Use of the GenXpert to Detect Hepatitis C RNA Using a Finger Prick; a Cross-sectional, Multicentre Study Among Drug Users

Conditions
-----------------
Drug Use, Hepatitis C

Intervention / Treatment
-----------------
* Other: screening: HCV RNA test and risk factors questionaire


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Have recently or ever used drugs Older than 18 years Written informed consent Exclusion Criteria: Not being able to speak the Dutch language

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: drug users<br> | Other: screening: HCV RNA test and risk factors questionaire<br>* Screening by using a rapid finger prick test for HCV RNA and a questionnaire to assess risk factors.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Questionaire to determine the satisfaction of the use of the GenXpert | 1. To determine how the caregiver and the client experience the use of the GenXpert and what place the device can have in primary care. a. A questionnaire to determine the satisfaction of the user and the person tested | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The detection of HCV RNA | a. One finger prick to measure the HCV RNA. These blood samples are processed directly using the HCV Viral Load fingerstick cartridge which is processed via the GenXpert device. | Baseline |
Preoperative and Intraoperative Factors Related to the Development of Ptosis After Retinal Surgery

Study Overview
=================
Brief Summary
-----------------
The purpose of this study to is to determine the incidence of post-operative ptosis in patients undergoing vitreoretinal surgery. An additional purpose is to identify pre-operative and intra-operative factors which correlate to the development of post-operative ptosis in vitreoretinal surgery cases.

Detailed Description
-----------------
This study will evaluate patients who will undergo vitreoretinal surgery at UCSF Medical Center and San Francisco General Hospital. After informed consent has been obtained, the measurement of eyelid parameters such as levator function, palpebral fissure height, upper eyelid crease height, MRD1 and MRD2 will be collected at pre-operative and post-operative follow up visits. External eye photographs taken at each visit will be evaluated by a masked reader who will calculate the eyelid parameters. Dermographic data and intraoperative factors such as operative time and type of procedure will be collected. For statistical analysis, Repeated ANOVA, Paired t-test, Wilcoxon signed rank test, Chi-square test and Pearson's correlation analysis will be calculated with SPSS software.

Official Title
-----------------
Preoperative and Intraoperative Factors Related to the Development of Ptosis After Retinal Surgery

Conditions
-----------------
Development of Ptosis After Vitreo-retinal Surgery

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who have vitreoretinal surgery from January 2013 Exclusion Criteria: Minors, younger than age 18. Patients who have pre-existing ptosis at baseline in the operative eye. Patients who are not able to cooperate with eyelid ptosis measurements

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction of levator function | Difference between levator function at baseline and 6 months after surgery | Baseline to 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Operative time | Record of operative surgical time in each type of operation | At operation | 
| Change of palpebral fissure height, MRD1 and MRD2 | Difference in palpebral fissure height, MRD1 and MRD2 between baseline and each post-operative visit. | Baseline to 6 months | 
| Incidence of ptosis | Incidence of clinically significant ptosis, defined as upper eyelid drooping of more than 2 mm. | baseline to 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ptosis, retina surgery, droopy eye lid