Prospective, Randomized, Parallel Clinical Controlled Study of Early Diet Opening on Postoperative Gastrointestinal Hemorrhage in Patients With Colonic Polyps

Study Overview
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Brief Summary
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Currently, hemorrhage remains the most common postoperative complication in patients with colon polyps, with an incidence of approximately 1.5%. The main reasons for postoperative hemorrhage are: the patient's own condition, the nature of the polyp and the operation. The number of patients treated for colon polyps has increased, postoperative care is confusing, medical resources are wasted, and the time span for postoperative diet recovery is large. However, studies on the effect of postoperative dietary recovery timing on postoperative polyp bleeding are rare.

Official Title
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Early Diet Opening on Postoperative Gastrointestinal Hemorrhage in Patients With Colonic Polyps

Conditions
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Colonic Polyp

Intervention / Treatment
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* Dietary Supplement: Early diet opening


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18-75, no gender restrictions, Patients with colonic polyps identified by colonoscopy and requiring endoscopic treatment, Polyp size 0.5cm-2cm, Patients agreed to enroll and signed a written informed consent, Adherence is good and agrees to be treated and evaluated as required by the study protocol. Exclusion Criteria: Patients with contraindications to endoscopic treatment of colonic polyps, including platelets ≤50×109/L, prothrombin time prolonged by 4 seconds or more, and INR≥2.0, Patients with severe heart, brain, lung, blood system diseases, uremia, connective tissue disease, Patients requiring treatment with NSAIDs, aspirin, glucocorticoids, or clopidogrel within the first 7 days of the study, During the course of the study, due to other concomitant/complications, patients who need to use drugs that affect the efficacy of the trial, including various anticoagulants, antiplatelet drugs and hemostatic drugs, Alcoholics, drug addicts or those with uncontrollable neuropsychiatric diseases and others who are not suitable for participating in the trial, Pregnant, breastfeeding women, or women in childbearing age who wish to become pregnant, Patients with malignant tumor of digestive system, Other circumstances in which the investigator believes that the patient should not participate in this trial

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control arm<br>patients were given a liquid diet 6 hours after the operation | |
| Experimental: Experimental arm<br>patients were given a liquid diet 2 hours after the operation | Dietary Supplement: Early diet opening<br>* Effects of early dietary recovery after colon polypectomy and colonoscopic mucosal resection on postoperative hemorrhage in patients<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative bloody stool | Postoperative massive hemorrhage: if the amount of blood in stool exceeds 400ml within 1 hour to 14 days after operation, or the hemoglobin decreases >2g/dl Ordinary hemorrhage: the amount of blood in stool does not meet the above standards | up to 2 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Colonic Polyp, Gastrointestinal Hemorrhage