Risk Factors Associated With Binge Drinking Behaviors Among College Students

Study Overview
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Brief Summary
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The purpose of this study is to specify the psychological, cognitive, neuro-functional and genetic profile associated with binge drinker behaviors among young adults. Results will help identifying more precisely vulnerability factors associated with this pattern of alcohol consumption and guiding prevention efforts.

Detailed Description
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Binge drinking behavior is characterised by speed of drinking on a particular occasion, frequency of drunkenness during the most recent six month period, and the percentage of times getting drunk when drinking. The prevalence of weekly binge drinking among European Union drinkers in 2009 was reported to be 28% of the student population, and 33% among all young people aged 15-24. The consequences of this behavior are multiple and often dramatic, they include: academic failure, violent acts, rape, domestic or road accidents. The study aims to identify vulnerability factors associated with binge drinking. The protocol explores the psychological (personality), neuropsychological (executive functions, memory), genetic (snp polymorphisms) and neuro-anatomical (fMRI) patterns associated with binge drinking behavior.

Official Title
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AlcoholPredict: Neuropsychology, Brain Imaging and Genetic Polymorphisms in Binge Drinking

Conditions
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Binge Drinking

Intervention / Treatment
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* Other: Alcoolpredict


Participation Criteria
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Eligibility Criteria
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Inclusion criteria : Males or females Right-handed Aged 18-25 years Native French speaker, able to read French and complete study evaluations Caucasian Able to provide informed written and verbal consent Exclusion criteria A significant general medical illness, including neurological disorders, mental retardation or head trauma Depression, bipolar disorder, schizophrenia or schizoaffective disorder diagnostic according to DSM-IV Handling of psychotropics substances A sensorial impairment (visual and/or hearing) Women who are pregnant Contraindication to the use of MRI (pacemaker, metal in their body)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Alcoolpredict|psychological (personality), neuropsychological (executive functions, memory), genetic (snp polymorphisms) and neuro-anatomical (fMRI)|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neuropsychological test : Mini International Neuropsychiatric Interview (M.I.N.I) |  | day 1 | 
| Neuropsychological test : Wisconsin Card Sorting Test (WCST) |  | V2(3 weeks later) | 
| Genetics tests (Single Nucleotide Polymorphism) |  | V2(3 weeks later) | 
| MRI - signal BOLD ( Blood Oxygen Level Dependant ). |  | V3(up to 2 month) | 
| Neuropsychological test : Family Informant Schedule and Criteria (FISC) |  | day 1 | 
| Neuropsychological test : Alcohol Use Questionnaire |  | day 1 | 
| Neuropsychological test :Trail Making Test, partie A et B |  | V3(up to 2 month) | 
| Neuropsychological test : Plus/Minus Test |  | V3(up to 2 month) | 
| Neuropsychological test :Go/No-Go |  | V3(up to 2 month) |