Outcome of COVID-19 Patients After Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome

Study Overview
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Brief Summary
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This study aims to investigate outcomes and predictors of outcome after extracorporeal membrane oxygenation (ECMO) therapy for severe acute respiratory syndrome (ARDS) in COVID-19 patients.

Detailed Description
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We evaluated the outcome of adult patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) requiring the use of extracorporeal membrane oxygenation (ECMO).

Official Title
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Outcome of COVID-19 Patients After Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome: A Multicenter European Study

Conditions
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COVID-19, Extracorporeal Membrane Oxygenation Complication, Acute Respiratory Distress Syndrome

Intervention / Treatment
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* Device: Extracorporeal membrane oxygenation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: PCR-confirmed or suspected COVID-19 infection with ARDS who require any ECMO therapy Exclusion Criteria: None
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| COVID-19 positive patients<br> | Device: Extracorporeal membrane oxygenation<br>* Veno-venous or veno-arterial extracorporeal oxygenation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| In-hospital mortality | All-cause mortality | Immediately after the intervention/procedure/surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Death on ECMO | Death during ECMO therapy | During the intervention/procedure/surgery | 
| Stroke | Stroke was defined as any focal or global neurological syndrome caused by ischemia and/or hemorrhage not resolving within 24 hours. | Immediately after the intervention/procedure/surgery | 
| Blood stream infection | Blood stream infection detected on blood cultures | Immediately after the intervention/procedure/surgery | 
| Lung complications requiring surgical treatment | Pneuthorax, pneumonia and/or abscess requiring surgical treatment | Immediately after the intervention/procedure/surgery | 
| Blood transfusion | Transfusion of red blood cells | Immediately after the intervention/procedure/surgery | 
| Acute kidney injury | Acute renal failure according to the Kidney Disease: Improving Global Outcomes classification (KDIGO) criteria | Immediately after the intervention/procedure/surgery | 
| Duration of mechanical ventilation | Duration of mechanical ventilation | During index hospital stay follow-up until 1 year after ECMO initiation | 
| Deep vein thrombosis | Thrombosis of lower limb deep venous system | Immediately after the intervention/procedure/surgery | 
| Pulmonary embolism | Pulmonary embolism | Immediately after the intervention/procedure/surgery | 
| Length of intensive care unit stay | Length of stay in the intensive care unit | Immediately after the intervention/procedure/surgery | 
| Length of hospital stay | Length of hospital stay | Immediately after the intervention/procedure/surgery | 
| Death after hospital discharge | All-cause death | Up to 6 months |