Screening Evaluation for Studies of Chronic Obstructive Pulmonary Disease (COPD)

Study Overview
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Brief Summary
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This research is being done to study mechanisms of progression of COPD and to develop treatments for it. The investigators are doing the present study to identify people age 40 and older with mild to moderate COPD who will qualify for such studies to include in a database. The study will include establishing a screening evaluation or characterization of the following two studies: Emphysema Progression in COPD- Losartan's Effects on Airway Parameters - NA_00009980 Sleep-Related Physiology and Inflammation in Chronic Obstructive Pulmonary Disease - NA_00001771

Detailed Description
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This is a program to recruit and screen participants for clinical trials or more detailed observational studies of COPD. There are no interventions or comparative results to be published from this study.

Official Title
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Screening Evaluation for Studies of COPD

Conditions
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Chronic Obstructive Pulmonary Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 40 years and older, either sex Mild to moderate COPD (FEV1/Forced vital capacity (FVC) ratio ≤ 0.70, FEV1 30-70% predicted, Diffusing capacity of the lungs for carbon monoxide (DLCO) ≥35% predicted) On stable maintenance therapy for 2 months Current or former smoker (patient report of at least a 10 pack-year history) Ability to understand and willingness to sign consent documents Exclusion Criteria: COPD exacerbation requiring treatment within past 6 weeks Untreated arterial hypertension (systolic blood pressure > 140 mm Hg, diastolic blood pressure > 90 mm Hg) Decompensated heart failure Myocardial infarction within past 3 months or ever Evidence of interstitial, occupational or chronic infectious lung disease Renal dysfunction Supplemental oxygen > 2 liters/m at rest Failure to keep screening appointments

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Establish a screening evaluation or characterization | We are doing the present study to identify people to include in a database who are age 40 and older with mild to moderate COPD and who will qualify for studies of COPD. The study will include establishing a screening evaluation or characterization for the following three studies. Emphysema Progression in COPD- Losartan's Effects on Airway Parameters - NA_00009980 Sleep-Related Physiology and Inflammation in Chronic Obstructive Pulmonary Disease - NA_00001771 Genetic Epidemiology of Chronic Obstructive Pulmonary Disease - NA_00011524 | Determined during screening clinical visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chronic Obstructive Pulmonary disease (COPD)