Invasive Left Heart Catheterization Registry

Study Overview
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Brief Summary
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Retrospectively enrolled suspicious of heart failure with preserved ejection fraction (HFpEF) patients who underwent left heart catheterization with the measurement of left ventricular end-diastolic pressure.

Detailed Description
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Heart failure (HF) with preserved ejection fraction (HFpEF) remains a poorly understood clinical syndrome without effective targeted therapies. The clinical syndrome of HFpEF develops from a complex interaction of several risk factors such as aging, obesity, hypertension, myocardial ischemia, and arterial stiffness that cause organ dysfunction and, ultimately, clinical symptoms. Although the H2FPEF and HFA-PEFF scores have recently been proposed to estimate the probability of HFpEF in patients suffering from unexplained dyspnea, diagnosing HFpEF remains still challenging. The aim of the current registry was to evaluate the role of invasive left heart catheterization with the measurement of left ventricular end-diastolic pressure (LVEDP) in suspicious of HFpEF patients.

Official Title
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Role of Invasive Left Heart Catheterization for Patients Suspected Heart Failure With Preserved Ejection Fraction

Conditions
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Heart Failure With Preserved Ejection Fraction, Left Ventricular Diastolic Dysfunction

Intervention / Treatment
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* Diagnostic Test: Left heart catheterization


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Left ventricular ejection fraction > 50% Patients who had a symptom and/or signs of heart failure (dyspnea on exertion, chest discomfort, fatigue, dizziness, or ankle edema) Patients who underwent left heart catheterization with the measurement of left ventricular end-diastolic pressure Exclusion Criteria: Left ventricular ejection fraction <50% Acute coronary syndrome More than moderate valvular heart disease Primary cardiomyopathies such as dilated cardiomyopathy and hypertrophic cardiomyopathy, amyloidosis Pulmonary arterial hypertension Heart transplantation Constrictive pericarditis Stress-induced cardiomyopathy

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Left heart catheterization<br>Symptomatic patients who underwent left heart catheterization and coronary angiography. | Diagnostic Test: Left heart catheterization<br>* Patients who underwent left heart catheterization<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rates of Death or re-hospitalization due to heart failure |  | 10 Years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rates of All-cause death |  | 10 Years | 
| Rates of Re-hospitalization due to heart failure |  | 10 Years | 
| Rates of Myocardial infarction |  | 10 Years | 
| Rates of Stroke |  | 10 Years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Heart failure with preserved ejection fraction, Left ventricular end diastolic pressure, Echocardiography