Anesthesia and Cancer Study: Renal Cell Carcinoma

Study Overview
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Brief Summary
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This study investigates the influence of type of anesthesia on recurrence and survival of renal cell carcinoma in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics, such as sevoflurane or desflurane.

Detailed Description
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The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, TIVA is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, to our knowledge, there is no study which investigates the influence of type of anesthesia on recurrence of renal cell carcinoma after nephrectomy.

Official Title
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The Influence of Type of Anesthesia on Recurrence of Renal Cell Carcinoma After Nephrectomy: a Prospective Randomized Controlled Study

Conditions
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Renal Cell Carcinoma

Intervention / Treatment
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* Drug: Propofol
* Drug: Inhaled General Anesthetics


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients scheduled for elective nephrectomy due to renal cell carcinoma Exclusion Criteria: Emergency surgery Pregnancy Allergies to anesthetics Palliative surgery Refusal to participate in the study History of diagnosis or surgery for other cancer

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: A prospective randomized controlled study
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: TIVA group<br>Patients receiving the total intravenous anesthesia using propofol | Drug: Propofol<br>* Propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia<br>|
| Active Comparator: inhalation group<br>Patients receiving inhalation anesthesia using sevoflurane or desflurane | Drug: Inhaled General Anesthetics<br>* Sevoflurane or desflurane for induction and maintenance of anesthesia<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| one year metastasis-free survival | one year metastasis-free survival | one years after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| three year metastasis-free survival | three year metastasis-free survival | three years after surgery | 
| one year survival | survival rate regardless of recurrence | one year after surgery | 
| three year survival | survival rate regardless of recurrence | three year after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Inhaled anesthetics, Anesthesia, Propofol, Renal cell carcinoma, Nephrectomy