Effects of Faba Bean Fractions as Ingredients in Novel Food Products on Glycemia, Appetite and Metabolic Control

Study Overview
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Brief Summary
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The investigators hypothesized that consuming crackers or pasta enriched with faba bean fractions (faba bean protein concentrate, faba bean protein isolate, faba bean flour and faba bean starch), would reduce the blood glucose response to the meal compared to foods without faba bean components and reduce food intake at a meal

Official Title
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Effects of Faba Bean Fractions as Ingredients in Novel Food Products on Glycemia, Appetite and Metabolic Control

Conditions
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Obesity, Diabetes

Intervention / Treatment
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* Dietary Supplement: Crackers/pasta with added faba bean protein concentrate
* Dietary Supplement: Crackers/pasta with added faba bean protein isolate
* Dietary Supplement: Crackers/pasta with added faba bean starch
* Dietary Supplement: Crackers/pasta with added faba bean flour
* Dietary Supplement: Crackers/pasta with no faba bean fraction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Non-smoking No metabolic disease BMI 20 - 25 kg/m^2 Male Age 18-30 Exclusion Criteria: Intolerance to treatments Currently taking appetite-modifying medications Restrictive eating Smoking Over- or underweight Breakfast-skipping

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control<br>Crackers/pasta with no faba bean fraction | Dietary Supplement: Crackers/pasta with no faba bean fraction<br>* Control treatment<br>|
| Experimental: Faba bean protein concentrate<br>Crackers/pasta with added faba bean protein concentrate | Dietary Supplement: Crackers/pasta with added faba bean protein concentrate<br>* Protein concentrate treatment<br>|
| Experimental: Faba bean protein isolate<br>Crackers/pasta with added faba bean protein isolate | Dietary Supplement: Crackers/pasta with added faba bean protein isolate<br>* Protein isolate treatment<br>|
| Experimental: Faba bean flour<br>Crackers/pasta with added faba bean flour | Dietary Supplement: Crackers/pasta with added faba bean flour<br>* Flour treatment<br>|
| Experimental: Faba bean starch<br>Crackers/pasta with added faba bean starch | Dietary Supplement: Crackers/pasta with added faba bean starch<br>* Starch treatment<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in blood glucose levels | Each participant will attend 5 sessions in total (randomized 5-arm cross-over design) | Starting at the beginning of each session (0 minutes, before consumption of treatment) and every 15 - 30 minutes up to 200 minutes (time of completion of each session) | 
| Change in gut hormone levels measured in the blood | Each participant will attend 5 sessions in total (randomized 5-arm cross-over design) | Starting at the beginning of each session (0 minutes, before consumption of treatment) and every 30 minutes up to 200 minutes (time of completion of each session) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Subjective appetite | Measured using Visual Analog Scales (VAS) | From 0 to 200 minutes | 
| Ad libitum food (pizza meal) intake as measured by the amount of pizza (in grams) consumed during the 20 minute period | Each participant will also answer questions related to physical comfort, motivation to eat, and rating feelings of energy and fatigue using Visual Analog Scales (VAS) | 120 minutes after completion of treatment, 20 minutes were allocated to allow for pizza consumption | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Food intake, Satiety, Appetite, Glycemia, Faba bean, Protein, Snack