Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke

Study Overview
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Brief Summary
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Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs. At present, there is no unified diagnostic criteria for acute liver injury associated with heat stroke, and the commonly used prognosis scores are rarely included in liver injury indicators, which is not good for practicality.

Detailed Description
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The project intends to collect the peripheral blood of the normal population, the 24 hours after the onset of heat stroke and the patients in the recovery period, to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to search for indicators related to disease deterioration and prognosis, construct and verify the early warning and prognosis evaluation system of the disease. On this basis, the researcher explore cellular and molecular mediated pathological mechanisms of heat stroke, and then clarify the treatment target of heat stroke.

Official Title
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Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke

Conditions
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Heat Stroke, Early Waking, MODS, Proteinosis, Liver Injury, Kidney Injury

Intervention / Treatment
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* Diagnostic Test: Peripheral blood test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: The patient voluntarily signs an informed consent form; Adult patients who meet the criteria for heat stroke; Heat stroke is defined as heat stroke (Heat Stroke, HS) is a serious fatal disease caused by heat injury factors acting on the body, accompanied by multiple organ damage. Exclusion Criteria: Age <18 years old or >90 years old; Patients with advanced tumors, Pregnancy or lactation; Patients who missed out during treatment and whose data are incomplete.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Control group<br>Healthy volunteers | Diagnostic Test: Peripheral blood test<br>* Collect peripheral blood to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to find indicators related to disease deterioration and prognosis<br>|
| Patients within the acute phase of disease<br>Patients within 24 hours after onset | Diagnostic Test: Peripheral blood test<br>* Collect peripheral blood to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to find indicators related to disease deterioration and prognosis<br>|
| Recovery stage of disease<br>Organ dysfunction was corrected, The patient had no obvious discomfort. | Diagnostic Test: Peripheral blood test<br>* Collect peripheral blood to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to find indicators related to disease deterioration and prognosis<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prognosis | Rate of Surviving or Died Participants with Heat Stroke | Day 30 and Day 90 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heat Stroke-associated kindey injury | Concentration of Creatinine(Cr)>2 mg/dl or Urine output < 500ml/Day | Day 0, Day 7 and On the day of discharge after improvement | 
| Heat Stroke-associated liver injury | Concentration of ALT or AST >80 U/L, Concentration of TBIL>2mg/dl（34μmol/l） | Day 0, Day 7 and On the day of discharge after improvement |