Independent Risk Factors Analysis and Model Construction For Recurrence After Radiofrequency/Microwave Ablation of Colorectal Cancer With Liver Metastases: a Retrospective, Multicenter Trial

Study Overview
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Brief Summary
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This study is a retrospective, multicenter clinical study. The main objective is to analyze the risk factors affecting the recurrence of colorectal cancer patients with liver metastases who received radiofrequency/microwave ablation. Finally, we will construct a recurrence risk prediction model based on the risk factors and validated the model.

Official Title
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Independent Risk Factors Analysis and Model Construction For Recurrence After Radiofrequency/Microwave Ablation of Colorectal Cancer With Liver Metastases: a Retrospective, Multicenter Trial

Conditions
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Colorectal Cancer With Liver Metastases

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age：older than 18 years； Patients with a single tumor diameter ≤5cm, no more than 3 tumor nodules, and the largest tumor diameter ≤3cm； Absence of vessel, bile duct and adjacent organ invasion and distant metastasis; The primary tumor of colorectal cancer has been resected, the liver metastases cannot be resected or the patient is unwilling to undergo surgery (clinical or pathological confirmation); Normal coagulation status and liver function child-pugh A or B; Liver metastases have not received other antitumor therapy after radiofrequency/microwave therapy (before disease progression); Routine laboratory tests were performed before the first RF/microwave treatment; Follow up for more than 12 months; Obtained free informed consent. Exclusion Criteria: Large tumor, or diffuse intrahepatic metastasis; Accompanied by vascular tumor thrombus or invasion of adjacent organs; The primary tumor of colorectal cancer has not been resected, with extrahepatic metastasis; Uncorrectable coagulation dysfunction and severe blood abnormalities, those with severe bleeding tendency; Intractable massive ascites, cachexia; Active infection, especially inflammation of the biliary system; Severe liver, kidney, heart, lung, brain and other major organ failure; Patients with impaired consciousness or unable to cooperate with treatment; Missing follow-up data.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The first recurrence of colorectal cancer with liver metastasis (CRLM) after radiofrequency/microwave ablation, assessed up to 18 months | The first recurrence of colorectal cancer with liver metastasis (CRLM) after radiofrequency/microwave ablation, assessed up to 18 months | Time from enrollment to disease recurrence, assessed up to 18 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Patients with colorectal cancer with liver metastases (CRLM) developed new metastases after radiofrequency/microwave ablation,assessed up to 18 months | Patients with colorectal cancer with liver metastases (CRLM) developed new metastases after radiofrequency/microwave ablation,assessed up to 18 months | Time from enrollment to developed new metastases, assessed up to 18 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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colorectal cancer with liver metastases, Radiofrequency/Microwave, Recurrence