Cabazitaxel in Platinum Refractory Ovarian Cancer

Study Overview
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Brief Summary
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Ovarian cancer patients are considered platinum refractory if their disease worsens during primary platinum treatment or if they have no effect of the treatment. This constitutes a major therapeutic problem and new treatment approaches are highly needed. Cabazitaxel (Jevtana®) is a new taxane with effect in breast and prostatic cancer. In both tumors it has effect in patients refractory to taxotere. Consequently, it could be anticipated that cabazitaxel may have an effect in platinum refractory ovarian cancer.

Official Title
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Cabazitaxel in Platinum Refractory Ovarian Cancer. A Phase II Trial

Conditions
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Ovarian Cancer

Intervention / Treatment
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* Drug: Cabazitaxel


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Histologically confirmed epithelial, primary fallopian or primary peritoneal cancer. Stages I-IV. Patients with refractory disease defined as progression or no change during primary treatment, as evaluated after 3 and/or 6 cycles of platinum/paclitaxel. Prior to inclusion, patients must have received platinum and paclitaxel as combination treatment. Measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or evaluable by Gynecologic Cancer Interest Group (GCIG) cancer antigen 125 (CA-125) criteria. Age ≥ 18 years. Performance stage 0-2. Adequate bone marrow function, liver function, renal function, and coagulation parameters (within 7 days prior to inclusion): Neutrophils (ANC) ≥ 1.5 x 10^9/l Platelet count ≥ 100 x 10^9/l Serum bilirubin ≤ 1.0 x upper limit of normal (ULN) Serum transaminase ≤ 2.5 x ULN Serum creatinine ≤ 1.5 ULN. If creatinine 1.0 - 1.5 x ULN, creatinine clearance will be calculated according to the Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI)and patients with creatinine clearance <60 mL/min should be excluded Written informed consent. Exclusion Criteria: History of severe hypersensitivity reaction (≥grade 3) to taxol. History of severe hypersensitivity reaction (≥grade 3) to polysorbate 80 containing drugs. Concurrent or planned treatment with strong inhibitors or strong inducers of cytochrome P4503A4/5 (a one week wash-out period is necessary for patients who are already on these treatments). Neuropathy grade ≥ 2. Pregnant or breast-feeding patients. For fertile women a negative pregnancy test at screening is mandatory. Fertile patients not willing to use effective methods of contraception during treatment and for 6 months after the end of treatment. Other malignant diseases within 5 years prior to inclusion in the study, except basal cell or squamous cell carcinoma of the skin and cervical carcinoma-in-situ. Other experimental therapy or participation in another clinical trial within 28 days prior to treatment initiation. History of any chronic medical or psychiatric condition or laboratory abnormality that is not medically controlled or in the opinion of the investigator may increase the risks associated with study drug administration. (e.g. diabetes, cardiac diseases, hypertension, renal, thyroid or liver disease). Vaccination with yellow fever vaccine or any live attenuated vaccine during the treatment. Treatment with disulfiram (antabuse)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cabazitaxel<br>25 mg/m2 IV every three weeks | Drug: Cabazitaxel<br>* 25 mg/m2 IV every three weeks<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of response to cabazitaxel | Response must be confirmed by a second CT scan 4-6 weeks after first response by CT scan | Every 9 weeks up to two years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Progression free survival |  | Every three months until progression or death, up to three years | 
| Overall survival |  | Every 3 months up to three years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ovarian cancer, Platinum refractory