Lutein Bioavailability From Fresh and Dried Beverages

Study Overview
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Brief Summary
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Macular pigment is composed primarily of the xanthophylls lutein and zeaxanthin, which are members of the carotenoid family. Epidemiological evidence indicates that a higher intake of lutein and zeaxanthin is associated with a lower risk to develop age-related macular degeneration (AMD). The lipid matrix of an egg yolk is an excellent vehicle for the efficient absorption of dietary lutein and it is possible to increase the natural lutein concentration in an egg yolk. A fresh lutein-enriched egg yolk beverage has been produced using these lutein-enriched egg-yolks. However, this beverage has a limited shelf life of maximum three weeks. Drying this fresh beverage extents the shelf live, however, this should be without loosing its functional properties concerning lutein bioavailability. At WUR-FBR two types of drying procedures have been evaluated resulting in two different dried product formulations, which need to be tested. The question is, whether the lutein bioavailability is not affected by different drying procedures.

Official Title
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Bioavailability of Lutein From a Lutein-enriched Egg-yolk-beverage and Its Dried Re-suspended Versions.

Conditions
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Macular Pigment

Intervention / Treatment
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* Dietary Supplement: Fresh lutein-enriched egg-yolk beverage
* Dietary Supplement: Dried-1 lutein-enriched egg-yolk beverage
* Dietary Supplement: Dried-2 lutein-enriched egg-yolk beverage
* Dietary Supplement: Placebo beverage


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age 18-35 years BMI 18-25 kg/m2 body weight should be stable for ≥6 months (with no weight gain/loss > 3 kg) Exclusion Criteria: use of medication except incidental use of pain killers pulmonary inhalation medication and except usage of the contraceptive pill chronic diseases such as IBD or other stomach or bowel diseases not willing to discontinue consumption of vitamin supplements allergic to cow milk / dairy products/ eggs/ egg-rich products vegetarians smoking pregnant or breastfeeding women having donated blood (as blood donor) within 1 month prior to the screening visit or planning to do so during the study impossible or difficult venapuncture

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Dietary Supplement: Fresh lutein-enriched egg-yolk beverage|Fresh lutein-enriched egg-yolk beverage|
|Dietary Supplement: Dried-1 lutein-enriched egg-yolk beverage|Dried-1 lutein-enriched egg-yolk beverage|
|Dietary Supplement: Dried-2 lutein-enriched egg-yolk beverage|Dried-2 lutein-enriched egg-yolk beverage|
|Dietary Supplement: Placebo beverage|Placebo beverage|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum lutein concentration |  | six weeks after intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum lipid concentrations |  | six weeks after intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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focus of study