A Study of PNT2258 in Patients With Advanced Solid Tumors

Study Overview
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Brief Summary
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This study is sponsored by Sierra Oncology, Inc. formerly ProNAi Therapeutics, Inc. The purpose of this research study is to evaluate the safety of the investigational drug PNT2258 in patients with advance tumors and see how it acts in the body.

Detailed Description
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This study is an open-label, single-arm, Phase 1 dose-escalation study of PNT2258 in patients with advanced solid tumors for which no standard therapy exists. Patients will receive PNT2258 as an intravenous infusion once daily for 5 consecutive days (Days 1-5) of every 21-day cycle (3 weeks). At first, patients will be treated in single patient cohorts following an accelerated titration design and evaluated for toxicities. After the accelerated portion ends, patients will be treated in cohorts of at least 3 patients at each dose level and evaluated for treatment-related toxicities.

Official Title
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A Phase 1 Study of PNT2258 in Patients With Advanced Solid Tumors

Conditions
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Cancer, Lymphoma, Prostate Cancer, Melanoma

Intervention / Treatment
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* Drug: PNT2258


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Histologically confirmed, malignant solid tumor (measurable or non-measurable disease) and cannot be a candidate for known regimens or protocol treatments of higher efficacy or priority. Recovered to Grade 1 from all acute toxicities of prior therapies, except for residual toxicities, such as alopecia, which do not pose an ongoing medical risk. ECOG performance status of 0, 1, or 2. At least 18 years of age. Patients must have normal organ and marrow function as defined by: Absolute neutrophil count 1,500/µL Platelets 100,000/µL Total bilirubin within normal institutional limits AST(SGOT)/ALT(SGPT) 2.5 x institutional upper limit of normal (ULN) or 5.0 x ULN in patients with liver metastases Serum creatinine 1.5 x ULN or measured creatinine clearance of 60 mL/min/1.73 m2. Negative serum pregnancy test at the time of enrollment for women of child-bearing potential. For men and women of child-producing potential, use of effective contraceptive methods is required during the study. Ability to understand the requirements of the study. Must provide written informed consent and authorization of use and disclosure of protected health information. Must agree to abide by the study restrictions and to return for the required assessments. Exclusion Criteria: Received previous anticancer chemotherapy, immunotherapy, radiotherapy or any other investigational therapy in the 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to study entry. Receiving any other investigational agents. Known brain metastases with the exception of patients with a history of treated brain metastases who are stable for at least 3 months off glucocorticoids and seizure medications. Prolongation of QT/QTc interval > 450 milliseconds (ms). Known HIV, HBV, or HCV infection. History of allergic reactions attributed to compounds of similar chemical or biologic composition to PNT2258. History of allergic reaction to egg or chicken antigens. Pregnant or nursing women. Uncontrolled intercurrent illness including, but not limited to ongoing or serious active infection, symptomatic congestive heart failure, unstable angina pectoris, serious cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: PNT2258<br>PNT2258 is composed of PNT100, a 24-mer oligonucleotide, the active drug substance encapsulated in a liposome. | Drug: PNT2258<br>* Patients will receive PNT2258 as an intravenous infusion once daily for 5 consecutive days (Days 1-5) of every 21-day cycle (3 weeks). The treatment cycle repeats every 3 weeks for up to 6 cycles in the absence of disease progression, unacceptable toxicity, or patient withdrawal from the study.<br>* Other names: PNT-2258;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To determine the safety of PNT2258 in patients with advanced solid tumors | Safety and tolerability of PNT2258 and the determination of dose-limiting toxicities (DLTs) and the recommended Phase 2 dose | Ongoing | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pharmacokinetic profile of PNT2258 |  | Ongoing | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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PNT2258, Oligonucleotide, DNAi, Oncology, Antineoplastic agent, Lymphoma