linjc16/ctgov huggingface dataset:
Diffusion Tensor Imaging of Sural Nerves in Diabetic Peripheral Neuropathy

Study Overview
=================
Brief Summary
-----------------
This study aims to validate magnetic resonance imaging and diffusion tensor imaging (MRI/ DTI) analysis as a non-invasive method for the assessment of myelinated nerve fibers loss in diabetic peripheral neuropathy.

Official Title
-----------------
Diffusion Tensor Imaging of Sural Nerves in Diabetic Peripheral Neuropathy

Conditions
-----------------
Diabetic Peripheral Neuropathy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Presence of diabetes mellitus diagnosed for more than 6 months as defined by the World Health Organization Classification. Presence of confirmed DPN as defined below. Age between 18-70 years. Have no risk factors for other non-diabetic neuropathies (as determined by medical history, family history, history of medications, occupational history, history of exposure to toxins, physical and neurological examinations). Willingness to provide informed consent and cooperate with the medical procedures for the study. Inclusion Criteria for Healthy Controls: Age-matched non-obese (BMI < 30) control subjects Normal glucose tolerance Normal blood pressure Normal lipid profile Free of any causes of neuropathy as described above. Exclusion Criteria: Nursing mothers or pregnant women (excluded by a positive pregnancy test). Patients with a history of previous kidney, pancreas or cardiac transplantation. Patients with a past history of neuropathy (independent of diabetes), or with a disease known to be associated with neuropathy (e.g. end stage renal disease, hepatitis C, systemic lupus erythematosus). Participation in an experimental medication trial within 3 months of starting the study. Subjects with implantable cardioverter defibrillators and other devices that would preclude MRI scanning. Subjects who are unable or unwilling to comply with the experimental protocol.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Diabetic peripheral neuropathy | |
| 2<br>Healthy controls | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The difference in means between DTI parameters (FA and MD) measured in the sural nerve between subjects with DPN and healthy control subjects. |  | 12-18 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The association between DTI parameters and clinical and electrophysiological measures of DPN |  | 12-18 months |
High Flow Nasal Cannula vs Noninvasive Ventilation in Patients With Hypoxic Respiratory Failure Following Blunt Chest Trauma

Study Overview
=================
Brief Summary
-----------------
to compare high flow nasal cannula against noninvasive ventilation in patients with non-sever blunt chest trauma in improvement of oxygenation, need for intubation and mechanical ventilation within 28 days

Official Title
-----------------
High Flow Nasal Cannula vs Noninvasive Ventilation in Patients With Hypoxic Respiratory Failure Following Blunt Chest Trauma, a Randomized Clinical Trial

Conditions
-----------------
Blunt Injury of Thorax

Intervention / Treatment
-----------------
* Device: high flow nasal cannula
* Device: noninvasive ventilation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥18 y, Willing and able to provide written informed consent prior to performing study procedures, currently hospitalized and requiring medical care for non-sever blunt chest trauma (abbreviated injury severity scale ≤ 2) SpO2 90% or less while breathing 10 L/min. Exclusion Criteria: Contraindications of noninvasive ventilation (face trauma or surgery, airway obstruction, upper gastrointestinal tract bleeding, disturbed level of consciousness), -smoker intubation for any cause other than respiratory cause

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: high flow nasal cannula<br> | Device: high flow nasal cannula<br>* high flow nasal cannula<br>|
| Active Comparator: noninvasive mechanical ventilation<br> | Device: noninvasive ventilation<br>* noninvasive ventilation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| PaO2/FiO2 ratio | mean value of three successive PaO2/FiO2 ratio in mmHg between both groups | 3 successive days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Discomfort score | Discomfort related to oxygen delivery devices will be evaluated using a 10- point numeric scale which low number is low discomfort. | 3 successive days |
The Influence of Aerobic Endurance Training After Roux-en-Y-Gastric Bypass

Study Overview
=================
Brief Summary
-----------------
The aim of this study was to assess the efficiency of aerobic physical exercise (APE) on weight loss, body composition and co-morbidities in patients after laparoscopic Roux-en-Y Gastric bypass (RYGBP).

Detailed Description
-----------------
The only effective treatment for patients with morbid obesity is bariatric surgery. Sudden weight loss following bariatric operations for morbid obesity, such as Roux-en-Y gastric bypass (RYGBP) can result in a concurrent decrease in lean body mass. However the long-time results (weight reduction, elimination co-morbidities) are depending on the post operative treatment. Aerobic physical exercising (APE) is well accepted in conservative treatment of obesity as well as of diabetes mellitus type 2 (DM). The aim of this study was to assess the efficiency of APE on weight loss, body composition and co-morbidities in patients after laparoscopic Roux-en-Y Gastric bypass (RYGBP).

Official Title
-----------------
Impact of Aerobic Physical Exercising on Body Composition and co-Morbidities in Patients After Laparoscopic Roux-en-Y Gastric Bypass

Conditions
-----------------
Morbid Obesity

Intervention / Treatment
-----------------
* Other: aerobic endurance training
* Other: aerobic endurance training


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Obesity WHO III Exclusion Criteria: Contraindications of aerobic endurance training

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| multiple-exercise group (ME)<br>participants exercised 2 times weekly for 1 hour (aerobic endurance training) | Other: aerobic endurance training<br>* participants exercises 2 times weekly for 1 hour (aerobic endurance training)<br>* Other names: aerobic physical exercise;|
| Low-exercise group (LE)<br>participants exercises 1 time weekly for 1 hour (aerobic endurance training) | Other: aerobic endurance training<br>* participants exercised 1 time weekly for 1 hour (aerobic endurance training)<br>* Other names: aerobic physical exercise;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| effects of aerobic physical exercising (APE) on weight loss |  | 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| effects of aerobic physical exercising (APE) on co-morbidities |  | 10 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bariatric surgery, co-morbidities, aerobic physical exercise
A Clinical Trial of a Self-Management Education Program for People With Chronic Stable Angina

Study Overview
=================
Brief Summary
-----------------
The purpose of this clinical trial was to determine the effectiveness of a supportive and educational self-management program for improving health-related quality of life (HRQOL), angina symptoms, and self-efficacy and resourcefulness to self-manage for chronic angina patients. 130 participants were enrolled in the trial for 3 months. The program, entitled the Chronic Angina Self-Management Program, (CASMP) was found effective for improving HRQOL, angina symptoms, and self-efficacy to manage symptoms, compared to usual care.

Official Title
-----------------
A Psychoeducation Trial for People With Chronic Stable Angina

Conditions
-----------------
Chronic Stable Angina

Intervention / Treatment
-----------------
* Behavioral: Psychoeducation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Medical diagnosis of coronary artery disease CCS Class I-III Angina for at least 6 months Speak, read, understand English - Exclusion Criteria: MI/Bypass last 6 months CCS Class IV angina A major cognitive disorder -

Ages Eligible for Study
-----------------
Minimum Age: 0 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Psychoeducation|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SF36 |  |  | 
| Seattle Angina Questionnaire |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Self-Efficacy Scale |  |  | 
| Self-Control Schedule |  |  |
Myo-inositol Versus Metformin Administration in Post-menopausal Women With Metabolic Syndrome

Study Overview
=================
Brief Summary
-----------------
Myo-Inositol is classified as a member of the vitamin B complex. It is a constituent of living cells and is widespread in many food. It is involved in a number of biological processes, including insulin signal transduction, resulting in modulating insulin sensitivity. One hundred post-menopausal women from 50 to 60 years old, affected by metabolic syndrome (criteria are described in NIH ATP III) will be randomized into two groups: 50 treated with myo-inositol 2 g twice per day and fifty treated with metformin for six months. Metformin is the drug usually used in diabetic and pre-diabetic conditions, as metabolic syndrome. The investigators hypothesize that the administration of myo-inositol would improve the insulin-receptor activity in these women, reducing insulin resistance as well as metformin. OUTCOME MEASURE: HOMA-IR, blood pressure level, serum triglycerides and cholesterol, BMI and waist circumference

Conditions
-----------------
Metabolic Syndrome

Intervention / Treatment
-----------------
* Dietary Supplement: myo-inositol
* Drug: Metformin


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Post-menopausal outpatients affected by the metabolic syndrome, whose criteria are described in NIH ATP III, 2001. Exclusion Criteria: Post-menopausal outpatients without metabolic syndrome assumption of hypocholesterolemic or other insulin sensitizing drugs

Ages Eligible for Study
-----------------
Minimum Age: 50 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: metformin<br> | Drug: Metformin<br>* pill, 250 mg, twice a day<br>|
| Active Comparator: myo-inositol<br> | Dietary Supplement: myo-inositol<br>* 2 grams twice a day<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| glycaemia, insulinaemia, HOMA-IR |  | at baseline and after 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| serum triglycerides, HDL and total cholesterol, blood pressure level, BMI and waist circumference |  | at baseline and after six months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
insulin resistance, body mass index, myo-inositol, serum triglycerides and cholesterol, blood pressure, metformin
Neural Therapy Effect and Bilateral Tubal Ligation

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to evaluate the effect of nebulisation in patients with bilateral tubal ligation in the first postoperative year, the amount of dysmenorrhea, dyspareunia and menstrual bleeding, recurrent vaginitis and cystitis. A retrospective analysis of bilateral tubal ligation with optional modified Pomeroy technique in the family planning unit and evaluation of the results of patients who underwent Neural Therapy during and postoperatively will be evaluated.

Official Title
-----------------
Evaluation Of The Neural Therapy Effect On Long Term Postoperative Discomforts İn Patients Who Undergo Bilateral Tubal Ligation

Conditions
-----------------
Tubal Obstruction, Dysmenorrhea

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients who underwent bilateral tubal ligation with modified Pomeroy technique, Patients with dysmenore, dyspareunia and menstrual bleeding, Exclusion Criteria: postoperative asymptomatic Additional treatments for pain and complaints

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative dysmenorrhea | Postoperative dysmenorrhea in the first postoperative year was evaluated by viscous pain scale (VAS) in patients who underwent bilateral tubal ligation with the modified Pomeroy technique. There is no pain at zero points according to visuel pain scale;Ten points are very severe - unbearable pain. patients will score between one to ten pains. | 1st year postoperative | 
| postoperative dyspareunia | Postoperative dyspareunia in the first postoperative year was evaluated by viscous pain scale (VAS) in patients who underwent bilateral tubal ligation with the modified Pomeroy technique. There is no pain at zero points according to visuel pain scale;Ten points are very severe - unbearable pain. patients will score between one to ten pains. | 1st year postoperative | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Bilateral Tubal Ligation, Postoperative Discomforts
Screen of DM by OGTT in Subjects Receiving CAG or MDCT for CAD

Study Overview
=================
Brief Summary
-----------------
To determine the glucose regulation status of patients who were suspected to have CAD in central Taiwan.

Detailed Description
-----------------
It had been reported that high prevalence of IGT (impaired glucose tolerance) and unknown DM (diabetes mellitus) in patients with CAD (coronary artery disease). This study aimed to determine the glucose regulation status of patients who were suspected to have CAD in central Taiwan. In general, patient who were admitted for CAG (coronary angiography) or MDCT without known DM were eligible. After informed consent, OGTT (oral glucose tolerance test) was performed to determine the glucose regulation status. Study participants will be requested to complete questionnaires to assess their risk of diabetes and quality of sleep. Patients who were diagnosed as new DM would be asked to follow up in clinical service with diet control.

Official Title
-----------------
Screen of Diabetes Mellitus by Oral Glucose Tolerance Test in Subjects Receiving Catheterization or Multi-detector Computed Tomography (MDCT) for Coronary Artery Disease

Conditions
-----------------
Diabetes Mellitus, Coronary Artery Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient received CAG or MDCT for suspect CAD Without DM history Exclusion Criteria: Known DM Unstable disease condition Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diabetes | Based on OGTT and HbA1c | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brain-derived neurotrophic factor | An biomarker to link brain and atheroclerosis | 3 months | 
| Coroanry artery disease | Based on coronary angiography and medical record | 3 months | 
| Mortality | All-cause and cardiovascular | 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
DM, CAD, Meal tolerance test
Bioimpedance Based Monitoring of Operation Wound and Skin Graft Healing

Study Overview
=================
Brief Summary
-----------------
This study consists of two clinical series. With the first series investigators monitor the healing of skin grafts with bioimpedance measurements. The bioimpedance measurement is done with a purpose built patch that has electrodes in contact with the wound and reference electrodes. In the second series the investigators monitor closed operational wounds (breast reconstruction surgery patients) with bioimpedance measurements. This series is also conducted with bioimpedance measurements but the wounds are operational wounds. Both groups will have 20 patients.

Detailed Description
-----------------
Objectives of the study: The investigators will study how bioimpedance measurement results correlate with conventional wound healing monitoring. The investigators will seek the best methods for handling, interpreting and presenting bioimpedance measurement results. The investigators will find out if impedance measurement is applicable to clinical use.

Official Title
-----------------
Bioimpedance Based Monitoring of Operation Wound and Skin Graft Healing

Conditions
-----------------
Skin Graft, Closed Operation Wound

Intervention / Treatment
-----------------
* Other: Different type of wound


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients that have a skin graft operation made as part of their treatment patients that have breast reconstruction surgery made as part of their treatment Exclusion Criteria: pregnancy patients with limited capacity to understand the information regarding the study patients with chronic skin disease on operation area

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Skin graft<br>The bioimpedance measurement is done with a purpose built patch that has electrodes in contact with the wound and reference electrodes. | Other: Different type of wound<br> <br> |
| Operation wound<br>The bioimpedance measurement is done with commercial electrodes places in healthy skin surrounding the wound. | Other: Different type of wound<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bioimpedance data | Bioimpedance values between selected measuring points with different frequencies | 2 months |
Obesity-related Genes in Taiwanese Undergoing Weight Loss

Study Overview
=================
Brief Summary
-----------------
To investigate: Associations between miRNA and insulin signaling-related gene expressions in abdominal adipose tissues in obese subjects. Differences in miRNAs expressed by intrabdominal omental adipose tissues between genders.

Detailed Description
-----------------
Compared the differences in microRNA expressions of abdominal adipose tissue in morbid obese male and female subjects to elucidate the possible regulatory role of microRNA in insulin signaling-related gene expression levels and its association with biochemical markers. We hope to find a miRNA that can be used to predict the syndrome associated with obesity.

Official Title
-----------------
Searching for the Most Influential Obesity-related Diabetic Genes and Exploring the Expression Profiles of Those Genes in Taiwanese Undergoing Weight Loss

Conditions
-----------------
Morbid Obesity

Intervention / Treatment
-----------------
* Genetic: gender


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Morbid obesity,BMIs> 40 kg/m2 Subjects who underwent bariatric surgery Exclusion Criteria: Obese subjects with complicated metabolic disorders Thyroid disease

Ages Eligible for Study
-----------------
Minimum Age: 19 Years
Maximum Age: 63 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| gender<br>Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men and women who underwent bariatric surgery. | Genetic: gender<br>* Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men and women who underwent bariatric surgery.<br>* Other names: BMI were all over 40 kg/ m2;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MicroRNA expression in abdominal omental adipose tissues | MicroRNA-125a-3p expression in abdominal omental adipose tissues is associated with insulin signaling-related gene expression levels in morbid obesity | up to 28 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
abdominal adipose tissue; microRNA