Sex and Obesity: Effects on Heart Failure Study

Study Overview
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Brief Summary
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Sex has a major impact on myocardial metabolism and blood flow. In subjects without heart failure men's hearts tend to use proportionally more glucose and women's hearts use more fat and have higher blood flow. Obesity is a major risk factor for Heart Failure. In subjects without heart failure, increasing body mass index is predictive of increased blood flow and fatty acid metabolism in women, but not men. To measure blood flow and metabolism we will be using radioactive materials and a PET (positron emission Tomography)scan to study the blood flow and substrate metabolism of the heart. Hypotheses: 1) Women with heart failure with reduced ejection fraction (HFreF) will have higher levels of heart blood flow and fatty acid metabolism and lower glucose metabolism rates than men with HFrEF. A secondary Aim is test the hypothesis that body mass index (BMI), a measure of obesity, correlates with myocardial blood flow and myocardial metabolism measures in patients with HFrEF.

Official Title
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Sex and Obesity Effects on Myocardial Blood Flow and Metabolism

Conditions
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Obesity, Heart Failure

Intervention / Treatment
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* Procedure: PET (positron Emission Tomography)
* Procedure: Echocardiogram
* Procedure: VO2 peak test
* Procedure: Body composition Study
* Radiation: 15O water
* Radiation: 11C Acetate
* Radiation: 11C Palmitate
* Radiation: 11C Glucose


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: men and women Non Ischemic Heart failure, ejection fraction <40%, age 20-65, non diabetic Exclusion Criteria: Pregnancy, lactating, actively losing weight, nonsedentary, greater than Class I hypertension,require alterations in heart medications, Diabetes, use of exogenous hormones.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| heart failure<br>Obesity related Heart failure population | Procedure: PET (positron Emission Tomography)<br>* this is a diagnostic scan that requires the injection of radioactive tracers into an IV placed in the arm.<br>* Other names: PET scan;Procedure: Echocardiogram<br>* an ultrasound of the heart<br>* Other names: Echo;Procedure: VO2 peak test<br>* walking on a treadmill during which you will breath in and out through a tube<br>Procedure: Body composition Study<br>* a scan of your entire body measuring Body Mass Index, fat percentage etc...<br>* Other names: DEXA scan;Radiation: 15O water<br>* radioactive tracer used to study blood flow during the PET scan<br>Radiation: 11C Acetate<br>* radioactive tracer that helps study heart metabolism<br>Radiation: 11C Palmitate<br>* radioactive tracer used to study fatty acid usage in the heart<br>Radiation: 11C Glucose<br>* radioactive tracer usde to study glucose usage in the heart<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Myocardial blood flow | The heart needs blood flow for all of its functions. | the time frame of the study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Myocardial fatty acid utilization | The heart uses fats to make energy for contraction and relaxation | The time frame of the study (a cross-sectional study) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Failure, radiation, Obesity, Heart, PET (positron emission tomography), metabolism