Arterial Inflow and Muscle Ischemia During Calf Stimulation With the Veinoplus Device

Study Overview
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Brief Summary
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Stimulation of arterial inflow to the lower limb is important to obtain functional improvement in peripheral artery diseased (PAD) patients with claudication. The clinical effect of muscle stimulation to increase arterial inflow and the direct evaluation of the regional blood flow impairment (RBFI) in the area of stimulation, have not been evaluated in PAD patients. Fifteen adult patients with stable arterial claudication will participate. Recruitment will be performed among patients referred for exercise oxymetry (treadmill: 3.2km.h-1, 10% slope) After two minutes of rest, the gastrocnemius will be stimulated for 20 minutes at an increasing frequency rate with 5 min steps (1 Hz, 1.25 Hz, 1.5 Hz and 1.75 Hz) on the most symptomatic side. The investigators record the tcpo2 value, arterial blood inflow with ultrasound of the femoral artery, and near infra-red spectrometry (NIRS) on both sides. Patients will be instructed to report eventual contraction-induced pain in the stimulated calf.

Detailed Description
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Investigations are conducted in an air-conditioned 22+/-2 °C room, with the patient comfortably seated on an armchair. Measured ware started at rest and performed throughout the period pf stimulation and for 10 minutes after the end of the stimulation Muscle stimulation: We apply a series of 20 minutes of stimulation with the Veinoplus® device. The device delivers a stimulation of incremental rate with 5 minutes intervals, with 1 Hz, 1.25 Hz, 1.5 Hz and 1.75 Hz and then stops automatically. Ultrasound measurements The Diameter of the superficial femoral artery was measured at rest on both sides before each study. The VTI of 3 cardiac cycles (three peaks systolic velocity) will be measured by duplex ultrasound imaging, to calculate the arterial inflow to the leg. Results will be expressed in l /min. Tcpo2 recording TcpO2 is measured at the chest and on both calves with TCM 400 (Radiometer, DK). Results are expressed in DROP index(mmHg) values. Near Infra-red spectroscopy (NIRS) We use the ARTinis NIRS device (ARTinis; NL) to estimate tissue saturation (StO2) on both gastrocnemius muscles of the leg. Systemic hemodynamic parameters Systemic and diastolic arterial pressures and heart rate are recorded every two minutes using Dinamap V100 (GE france).

Official Title
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Investigation of the Arterial Effects of the Veinoplus(r) Stimlator Device.

Conditions
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Peripheral Artery Disease

Intervention / Treatment
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* Device: electrical muscle stimulation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: French native Stable stage 2 peripheral artery disease Patent femoral artery on both sides Age > 18 years Exclusion Criteria: Pregnancy Adults protected by maw

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: electrical stimulation<br>Evaluation of the effect of calf stimulation on flow and tissue oxygenation | Device: electrical muscle stimulation<br>* Duration of the stimulation 20 minutes<br>* Other names: Veinoplus device;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| arterial inflow | Ultrasound and doppler measurement of femoral inflow before, during and for 10 minutes after stimulation | during stimulation |