linjc16/ctgov huggingface dataset:
Imaging Techniques for Identifying Factors of Sudden Cardiac Death Risk

Study Overview
=================
Brief Summary
-----------------
Sudden cardiac death is a tragic event that strikes all age groups and is unfortunately increasing in prevalence. Because it is difficult to predict those at highest risk, this study is designed to test the hypothesis that new imaging techniques (magnetic resonance imaging [MRI] and computed tomography [CT]) are useful for identifying factors which put people at high risk for sudden death.

Detailed Description
-----------------
Some people with heart disease and a weak heart muscle experience abnormal electrical activity of the heart that may predispose them to sudden death. In light of this risk, it has been recommended that such patients undergo implantation of an implantable cardioverter defibrillator (ICD). Your doctors have determined that you are such a patient and are to undergo implantation of an ICD. It is unclear who among the many patients who undergo ICD implantation for this reason are at greatest risk of sudden death and therefore require electrical response from their ICD. This research is being done to determine whether new imaging tests, such as magnetic resonance imaging (MRI) or multi-detector computed tomography (MDCT), can be used to predict who is at highest risk of sudden death and require electrical response from their ICD.

Official Title
-----------------
Functional Energetics and Imaging for Phenotypic Characterization of Patients at Risk for Sudden Cardiac Death

Conditions
-----------------
Sudden Cardiac Death

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Left ventricular ejection fraction <or = 35% Planned implantable cardioverter-defibrillator (ICD) implantation for clinical indications (primary prevention) Exclusion Criteria: History of sudden death (secondary prevention) Contraindication to undergoing MRI (metallic implant, pacemaker, etc.)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sudden cardiac death |  | 6 month intervals | 
| cardiovascular death |  | 6 month intervals | 
| appropriate ICD discharge |  | 6 month intervals | 
| composite sudden cardiac death and appropriate ICD discharge |  | 6 month intervals | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| heart failure admission |  | 6 month intervals |
Conditioning With Volatile Anesthetics in Liver Transplantation

Study Overview
=================
Brief Summary
-----------------
The gap between the number of candidates for orthotopic liver transplantation and the availability of suitable liver grafts has led to a rise in deaths on most waiting lists. Strategies applied in many centers to minimize this deficit include living donation or split of a cadaveric organ for two recipients, domino transplantation, and the use of so-called expanded criteria donors. Alternatively, conditioning of an organ would also allow protec-tion of the liver upon ischemia-reperfusion injury, possibly decreasing postoperative liver function and im-proving clinical outcome. The technique of conditioning with the volatile anesthetic sevoflurane is an easily applicable procedure which could be performed in any center worldwide. Data and experience with sevoflurane attenuating ischemic-reperfusion injury in liver resection lead to the hypothesis of a beneficial effect of volatile anesthetics in liver transplantation. In this randomized controlled trial, patients will be randomly assigned to liver transplantation with propofol anesthesia (propofol group) or sevoflurane conditioning with the volatile anesthetic (sevoflurane group). Primary endpoint is postoperative peak of the transaminase (AST), secondary endpoints are complications, primary liver graft function, ICU and hospital stay. We hypothesis that patients with conditioning have an attenuated increase of transaminases as well as a better outcome.

Conditions
-----------------
End-stage Liver Disease

Intervention / Treatment
-----------------
* Drug: Propofol
* Drug: Sevoflurane


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Older than 18 years Patients undergoing liver transplantation Total or partial cadaveric liver transplantation Living related liver transplantation Exclusion criteria: Patients unable to understand the German or Italian language Patients with known or suspected allergy to propofol, soja or egg Patients with norepinephrine infusion above 15 microg/min Intensive care patients with severe impairment of renal or pulmonary function (e.g. dialysis, hemofiltration, FiO2>0.5)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Sevoflurane anesthesia<br> | Drug: Sevoflurane<br> <br> |
| Other: Propofol anesthesia<br> | Drug: Propofol<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative paek of AST |  | 4 y |
Peripheral Perfusion Index (PPI) as Monitor During Deliberate Hypotensive Anesthesia

Study Overview
=================
Brief Summary
-----------------
Hypotensive anesthesia is effective in reducing the intraoperative blood loss. The risk of hypoperfusion of vital organs continues to be a concern. An adequate monitoring of tissue perfusion and oxygenation is crucial issue. Peripheral Perfusion Index (PPI) as a noninvasive new monitoring, can reflect the peripheral perfusion dynamics. This study is designed to explore the behaviour and trend of PPI during nitroglycerine induced deliberate hypotensive anesthesia in adult patients undergoing functional endoscopic sinus surgery (FESS).

Official Title
-----------------
The Use of Peripheral Perfusion Index as a Predictor for Patient's Response to Deliberate Hypotension During Functional Endoscopic Sinus Surgery A Prospective Observational Study

Conditions
-----------------
Monitoring During Deliberate Hypotensive Anesthesia

Intervention / Treatment
-----------------
* Other: peripheral perfusion index measurement


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients, aged from 18-50 years, ASA physical status I and II, undergoing functional endoscopic sinus surgery (FESS) under deliberate hypotensive anesthesia Exclusion Criteria: Patients with systemic hypertension, cardiovascular disease, cerebrovascular insufficiency, coagulation defects, renal or hepatic insufficiency, and hypersensitivity to the study drugs will be excluded from the study. Patients receiving vasoactive drugs or beta blockers will be also excluded from the study.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: peripheral perfusion index measurement|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| correlation between PPI and T1 | correlation of baseline values of PPI and time required to achieve target mean arterial pressure. | start of nitroglyceirn infusion till target arterial pressure is reached up to 2 hours |
Fluid Balance and Clinical Outcomes

Study Overview
=================
Brief Summary
-----------------
This study is about investigating the relationship of postoperative fluid balance, inflammation and acute kidney injury. This is a non-interventional study (no drug administration). The investigators will collect baseline demographic data, postoperative fluid balance status by Intake-output data, follow routine labs and collect 1 blood sample (0.5ml) with morning lab draws on day 1 and 5ml urine samples on day 1 and 2.

Official Title
-----------------
Investigation of the Effect of Post-operative Fluid Balance on Inflammatory Mediators in Patients Undergoing Cardiovascular Surgery

Conditions
-----------------
Fluid Balance, Input and Output, Inflammatory Mediators, Acute Kidney Injury, Mortality

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18 years or older, and Undergoing elective cardiothoracic surgery(s), alone or in combination with other procedures/surgery(s): thoracic aortic aneurysm, cardiac valves, coronary artery bypass grafting, abdominal thoracic aneurysm, and other cardiovascular surgery. Exclusion Criteria: Pregnancy History of any organ transplant Preoperative intra-aortic balloon pump (IABP) Current use of natriuretic peptides ESRD patients on dialysis Estimated GFR < 30ml/min using MDRD equation.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Positive Fluid Balance of 2000ml<br> | |
| Negative Fluid Balance of 2000ml<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Can Medical Personnel Properly Proceed in the Case of a Patient With Bradycardia?

Study Overview
=================
Brief Summary
-----------------
The study aims to assess the regularity of the proceedings in the case of a patient with bradycardia ECG.

Official Title
-----------------
Can Medical Personnel Properly Proceed in the Case of a Patient With Bradycardia?

Conditions
-----------------
Bradycardia

Intervention / Treatment
-----------------
* Device: electrostimulation
* Device: cardiopulmonary resuscitation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: give voluntary consent to participate in the study maximum 1 year of work experience in medicine paramedics, nurses, physicians Exclusion Criteria: not meet the above criteria wrist or low back diseases pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Bradycardia<br>Treatment In case of bradycardia. The patient unconscious, breathing preserved in ECG - bradycardia 40 / min with pulse. | Device: electrostimulation<br>* Electrostimulation using manual defibrillator<br>|
| Experimental: PEA<br>In case of bradycardia. The patient unconscious, not breathing, the ECG - bradycardia 30 / min - no pulse. Pulseless electrical activity | Device: cardiopulmonary resuscitation<br>* CPR according to guidelines of European Resuscitation Council. Cardiopulmonary resuscitation using manual defibrillator<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Questionnaire to assess effectiveness of the rhythm recognition and participants' knowledge on life-threatening rhythms | The effectiveness of the rhythm recognition. participants knowledge on life-threatening rhythms | intraoperative | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to take proper action | time from rhythm interpretation to proper conduct | intraoperative |
Ultrasound-guided Combined Spinal-epidural Anesthesia: Pre-procedure Versus Real-time Scan

Study Overview
=================
Brief Summary
-----------------
The investigators will compare the success rate, the consumed time, the number of needle passing, the depth and angle of the needle, the anesthetic effect, complications, pain and patient's satisfaction between 'Real-time scan' and 'Pre-procedure scan', when we performing spinal/epidural combined anesthesia.

Detailed Description
-----------------
Traditionally, spinal/epidural combined anesthesia has been performed by palpation of the landmark like Tuffier's line. There are some studies that using ultrasound improves the success rate to regional anesthesia. There are two methods of using ultrasonography, 'Real-time scan' and 'Pre-procedure scan'. Direct comparison of these two methods is not yet studied. So investigators will compare the success rate, the consumed time, the number of needle passing, the depth and angle of the needle, the anesthetic effect, complications, pain and patient's satisfaction.

Official Title
-----------------
A Randomized Comparison of the Ultrasound-guided Combined Spinal-epidural Anesthesia Technique: Pre-procedure Scan Versus Real-time Scan

Conditions
-----------------
Regional Anesthesia Morbidity, Ultrasonography

Intervention / Treatment
-----------------
* Procedure: realtime ultrasonography
* Procedure: prescan ultrasonography


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Spinal/Epidural combined anesthesia is required. Exclusion Criteria: Skin infection or trauma Abnormal coagulation lab History of spine surgery Pregnancy Abnormal structure of spine

Ages Eligible for Study
-----------------
Minimum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Pre-procedure<br>Confirmed landmark by ultrasound scan before procedure | Procedure: prescan ultrasonography<br>* Applying realtime ultrasound before the combined anesthesia<br>|
| Active Comparator: Real time<br>Confirmed landmark by ultrasound scan during procedure | Procedure: realtime ultrasonography<br>* Applying realtime ultrasound during the combined anesthesia<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of needle pass | Number of needle pass | intraoperative |
Asthma Control Study 2011

Study Overview
=================
Brief Summary
-----------------
Asthma control study 2011

Official Title
-----------------
Asthma Control Study 2011

Conditions
-----------------
Asthma Control Level

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Asthmatic patients above 18 y Exclusion Criteria: COPD pulmonary cancer pulmonary tuberculosis

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Asthma control level |  | 2 times | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Routine Therapeutical habits in control maintenance |  | 2 time | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
asthma control level , ACQ
Clinical Outcome of Laparoscopic Versus Open Nissen Fundoplication in Children: 3-Year Follow-up Study of Randomized Controlled Trial.

Study Overview
=================
Brief Summary
-----------------
Long-term results following laparoscopic and open Nissen fundoplication for gastro-oesophageal reflux will be objectively assessed in a selected population of patients already included in a randomized controlled trial comparing the two different techniques. The presence of postoperative symptoms will be evaluated by an independent clinician using an objective questionnaire. The recurrence of gastro-oesophageal reflux will be studied by 24-hours pH study. Furthermore the presence of gastric motility disorders will be studied by electrogastrography and 13C-octanoic acid breath test.

Conditions
-----------------
Gastro -Oesophagal Reflux

Intervention / Treatment
-----------------
* Procedure: open fundoplication
* Procedure: laparoscopic fundopliaction


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All patients with gastro - oesophagal reflux - Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 3 Years
Maximum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: open fundoplication|nan|
|Procedure: laparoscopic fundopliaction|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
LUEbeck Registry of Intensive Care Patients - Characterization of the Patients Intestinal MICROBIOME

Study Overview
=================
Brief Summary
-----------------
The purpose of the current study is to analyze the effects of ICU-care on changes in microbiome and the influence of intestinal microbiome changes on short-term and long-term morbidity and mortality of ICU patients.

Official Title
-----------------
LUEbeck Registry of Intensive Care Patients - Characterization of the Patients Intestinal MICROBIOME

Conditions
-----------------
ICU Patients

Intervention / Treatment
-----------------
* Other: Analyze changes in intestinal microbiome


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age ≥18 years All patients receiving intensive medical care A written informed consent from the patient or two independent doctors or legal guardians. Exclusion Criteria: Age <18 years

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Analyze changes in intestinal microbiome|Descriptive Analysis|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Modification of the microbiome | The modification of the microbiome using ribosomal 16 S DNA sequencing and clustering for Operational Taxonomic Units (OTU) and calculated Shannon Index | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| ICU intensive care unit stay | Duration | Day 0 | 
| Hospital stay | Duration | Month 12 | 
| Hospital stay | Duration | Month 6 | 
| Survival | To discharge | Month 6 | 
| Survival | To discharge | Month 12 |
Association of Air Quality and Myocardial Infarction

Study Overview
=================
Brief Summary
-----------------
Besides classical cardiovascular risk factors such as smoking, obesity, elevated cholesterol levels and diabetes there are also acute factors potentially triggering acute coronary events. The impact of various substances and air pollution are described. Particulate matter, especially with small particle size (<2.5µm) has been shown to have a positive correlation with myocardial infarctions. However, other studies failed to show this correlation. With respect to nitric oxydes the majority of published studies detected a significant correlation with myocardial infarction, too, although a highly ranked publication failed to show the same result. In addition data on the impact of sulfur dioxide and carbon monoxide concentration on cardiac events is very heterogeneous. Published data indicates additive effects of age and other epidemiological variables suggesting the need of a multivariate analysis. The rationale of the study is to test if the above mentioned air pollution factors have a significant and independent impact on the incidence of myocardial infarctions

Detailed Description
-----------------
The analysis will be performed in a well characterized patient cohort of 12.000 myocardial infarctions within 10 years being invasively diagnosed at the catheterisation centers of the styrian capital Graz.

Official Title
-----------------
Association of Air Quality and Myocardial Infarction

Conditions
-----------------
Acute Myocardial Infarction

Intervention / Treatment
-----------------
* Other: air pollution


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: myocardial infarction being confirmed or treated in the cathlab Exclusion Criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: air pollution|impact of various pollution agents above threshold and their correlation with acute myocardial infarctions are analyzed|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| myocardial infarction | the number of myocardial infarctions of every day analysed in this study will be correlated with the respective values of air polluting substances | 1 day |