Effect of Rosiglitazone on Myocardial Blood Flow Regulation in Type 2 Diabetes

Study Overview
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Brief Summary
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The overall hypothesis to be tested is that increased insulin resistance contributes to abnormal cardiac blood flow regulation in type 2 diabetic patients, which can be reversed by 6 months treatment with rosiglitazone. The planned experimental approach will be to utilize nuclear medicine techniques to evaluate whether the administration of rosiglitazone for 6 months can reverse regional deficits in myocardial blood flow and glucose utilization in type 2 diabetes in a randomized double blind controlled study. These studies will help elucidate the potential of rosiglitazone to correct deficits of myocardial blood flow complicating diabetes with the overall aim being the eventual prevention of sudden cardiac death.

Official Title
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Effect of Rosiglitazone on Myocardial Blood Flow Regulation in Type 2 Diabetes

Conditions
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Type 2 Diabetes

Intervention / Treatment
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* Drug: Rosiglitazone
* Drug: Glyburide


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Type 2 diabetes 30-75 years of age less than 1% fluctuation in HbA1c over 3 months women must be on contraception HbA1c 6-9% willingness to sign approved consent form Exclusion Criteria: Nursing mothers, pregnant women (excluded by a negative pregnancy test). Subjects requiring insulin therapy (>20 units/day) and can not be converted to sulfonylurea therapy without loss of diabetes control. Patients with a history of drug or alcohol dependence in the last 5 years Patients with pre-existing cardiovascular disease including coronary artery disease, heart attack, heart failure, abnormal heart rhythms, structural abnormalities and valve disease, peripheral vascular disease and uncontrolled high blood pressure. Patients with a history of high cholesterol requiring therapy. Patients with severe systemic disease other than diabetes which has as a recognized complication neuropathy Patients currently taking drugs which act on the blood vessels (for example for hypertension) Patients taking antidepressants, or other drugs or medications known to interfere with the uptake or metabolism of catecholamines (stress hormones) Patients with poor renal function or have significant liver disease Patients with a history of previous kidney, pancreas or cardiac transplantation. Patients with a history of severe hypoglycemia which required the assistance of a third party or ketoacidosis requiring hospital admission within the last 3 months. Patients with lung disease for example resulting from chronic obstructive airways disease. Patients with abnormal thyroid function tests. Patients having taken other systemic investigational drugs (especially for neuropathy) or initiating a new or experimental insulin delivery device within 3 months of starting the study. Patients with a history of allergic reactions to multiple drugs or biological products. Obese patients (BMI greater than 35). Patients who refuse to sign the informed consent.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br> | Drug: Rosiglitazone<br>* oral 8 mg/once daily for 6 months<br>|
| Experimental: 2<br> | Drug: Glyburide<br>* 20 mg/ once daily for 6 months<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Myocardial blood flow regulation |  | 6 months intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| biomarkers of oxidative/nitrosative stress |  | 6 month intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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insulin resistance, type 2 diabetes, myocardial perfusion, nitrosative stress, thiazolidinediones