linjc16/ctgov huggingface dataset:
Phase II Study of RR110 in Patients With Active Crohn's Disease

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics profile of 1 and 4 mg/kg/day RR110 administrated orally for 8 weeks in patients with active Crohn's disease.

Official Title
-----------------
Phase II Study of RR110 in Patients With Active Crohn's Disease

Conditions
-----------------
Crohn's Disease

Intervention / Treatment
-----------------
* Drug: RR110 (Tamibarotene)
* Drug: RR110 (Tamibarotene)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with CDAI score ranging from 220 to 450 Patients with CRP > 1 mg/dL Patients who can be hospitalized at least 2 weeks after first administration Exclusion Criteria: Patients who have previously used anti-TNF antibody, cyclosporine, methotrexate or tacrolimus within 12 weeks of screening Patients who have had surgical bowel resections within 4 weeks of screening Patients who have previously used total parental nutrition or more than 900 kcal/day of enteral nutrition within 4 weeks of screening

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1 mg RR110<br>1 mg RR110 | Drug: RR110 (Tamibarotene)<br>* 1 mg RR110<br>* Other names: Am80;|
| Experimental: 4 mg RR110<br>4 mg RR110 | Drug: RR110 (Tamibarotene)<br>* 4 mg RR110<br>* Other names: Am80;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Crohn's disease active index (CDAI) score |  | 8 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of clinical response as defined by CDAI decrease > 70 or 100 from baseline |  | 8 weeks | 
| Rate of clinical remission as defined by CDAI < 150 |  | 8 weeks | 
| Change in CRP, SAA, and fibrinogen levels, and IBDQ and CDEIS scores |  | 10 weeks | 
| Safety parameters |  | 10 weeks |
Acquired Resistant Mechanism of the First-generation EGFR TKIs

Study Overview
=================
Brief Summary
-----------------
Patients with advanced non-small-cell lung cancer (NSCLC) harboring sensitive epithelial growth factor receptor (EGFR) mutations invariably develop acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). Identification of actionable genetic mutations can be helpful for guiding the subsequent treatment. This study aimed to analyze the genetic profile of NSCLC harboring acquired resistance to the first-generation EGFR TKIs using next generation sequencing (NGS).

Official Title
-----------------
Identification of Genomic Mutation Profile Using Next Generation Sequencing for Non-small-cell Lung Cancer Patients With Activating EGFR Mutations Harboring Acquired Resistance to the First-generation EGFR TKIs.

Conditions
-----------------
Non-small Cell Lung Cancer, Aquired Resistance, EGFR TKIs

Intervention / Treatment
-----------------
* Other: Genetic: mutation profile


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Histologically proven stage IIIB or IV non-small cell lung cancer patients harboring sensitive EGFR mutations and received first-generation EGFR-TKIs who developed acquired drug resistance patients who can provide pre-treatment (EGFR TKIs) tumor tissues patients with tumor lesions to be re-biopsy after drug resistance patients must sign an informed consent indicating that they are aware of the .investigational nature of the study in keeping with the policy of the hospital. Exclusion Criteria: History of another malignancy except cured basal cell carcinoma of skin and cured carcinoma in-situ of uterine cervix patients with other systemic diseases
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Genetic: mutation profile|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mutation profile |  | 10 days |
Fecal Microbiota Transplantation in Gut aGVHD Treated

Study Overview
=================
Brief Summary
-----------------
With the stem cell transplanting increasing, patients which effected with gut GVHD were also increased. To evaluation the safety and efficacy of FMT for gut GVHD,patients with gut GVHD were recruited.

Official Title
-----------------
Department of Hematology of First Affiliated Hospital of Soochow University

Conditions
-----------------
Acute-graft-versus-host Disease

Intervention / Treatment
-----------------
* Biological: Fecal microbiota


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: gut GVHD Exclusion Criteria: Age>60; or Age<10

Ages Eligible for Study
-----------------
Minimum Age: 10 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: Fecal microbiota|fecal microbiota transplantation|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| times of stool | Change from stool times in a week | 24hours,48hours,72hours, 96hours,fifth day,sixth day, a week | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| volume in milliliter of stool | Change from stool volume in a week | 24hours,48hours,72hours, 96hours,fifth day,sixth day, a week |
Associative Memory in Adults With an Autism Spectrum Disorder

Study Overview
=================
Brief Summary
-----------------
The objective of this multidisciplinary project is to explore the deficit of associative memory in ASD (Autistic Spectrum Disorder) that could result from abnormal brain connectivity. The hypothesis of abnormal functioning of the fronto-hippocampal network has been evocated but has never been tested. Hence, the present project will include two complementary assessments conducted on a group of adults aged from 18 to 30 with ASD compared to a control group matched in chronological age and intellectual quotient. The first assessment is devoted to the study of associative memory and its EEG correlates and the second focused on the investigation of perceptual strategies related to associative memory using the technique of Eye-tracking. Both behavioral and imaging data would provide new insights on the relationship between perception and memory in ASD.

Official Title
-----------------
The Associative Memory in Autism Spectrum Disorders Without Intellectual Disability

Conditions
-----------------
Autistic Disorder

Intervention / Treatment
-----------------
* Device: Electroencephalography
* Behavioral: Neuropsychological assesments


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult between 18 and 30 years old right handed affiliated to the french national health care system ASD only for the group of patients Exclusion criteria : mental retardation schizophrenia ADHD brain injury with lost of consciousness neurological disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Patients<br>Adults between 18 and 30 years old right handing Patients with ASD | Device: Electroencephalography<br> <br> Behavioral: Neuropsychological assesments<br> <br> |
| Other: Healthy volunteers<br>Adults between 18 and 30 years old Right handing Healthy | Device: Electroencephalography<br> <br> Behavioral: Neuropsychological assesments<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The associative memory index |  | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| theta and gamma oscillations during the associative memory task |  | 2 years |
Comparing Google With A Focused Diabetes Search Engine

Study Overview
=================
Brief Summary
-----------------
Abstract Diabetes behavior can be influenced by patients exploring diabetes topics that may lack scientific credibility. The question this study examines is whether a Google or Health on the Net (HON) internet search, presents websites that would incline a more or less likely recommendation to patients ? A preliminary trial suggests that referrers recommend websites based on rules that may prioritize website source over content. This study will qualitatively assess the rules that participants use in deciding which websites are more suitable than others. Method The investigators will inject a diabetes related search term into a HON and a Google search engine. The top 5 mutually exclusive websites from each search engine will be presented to 5 people from three groups stratified across endocrinologists, informaticians and PCPs. Participants will rank the websites and then identify the rules that they applied to reach their decision.

Official Title
-----------------
Comparing Google With A Focused Diabetes Search Engine

Conditions
-----------------
Diabetes

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: physician, informatician, diabetologist Exclusion Criteria: -
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Primary Care Physicians<br> | |
| Diabetologists<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Website Ranking | Primary care and diabetes clinicians' preference in a set of webpage search results on a visual analog scale (1-100) with 1 being the lowest preference and 100 being the highest. Rankings based on qualitative measures, such as perceived clinical relevance, perceived accuracy of content, and perceived timeliness of content. | Immediate | 
| Search Engine Preference | Based on the results of primary outcome 1 (Website Ranking), preference for search engine was measured qualitatively between Google and Health-on-the-Net. | Immediate |
Effects of Tracheal Intubation on Ventilation With a Laryngeal Mask During Percutaneous Dilatation Tracheostomy

Study Overview
=================
Brief Summary
-----------------
The length of tracheal intubation may affect the subsequent ventilation with a laryngeal mask during percutaneous tracheostomy.

Detailed Description
-----------------
Percutaneous tracheostomy is routinely performed while patients are being ventilated with a laryngeal mask. The efficacy of ventilation during tracheostomy may be affected by length of previous endotracheal intubation. This is an observational and monocentric study aimed to evaluate the impact of length of endotracheal intubation on efficacy of lung ventilation with a laryngeal mask. Two groups of patients who have to undergo elective percutaneous tracheostomy after either a short or long endotracheal intubation will be enrolled. Data on the correlational effects of the endotracheal tube on the integrity of laryngeal structures and on ventilation will be collected. Statistical analyses will use standard tests to compare the two groups of patients.

Official Title
-----------------
Effects of Short- and of Long-term Tracheal Intubation on Ventilation With a Laryngeal Mask During Percutaneous Dilatation Tracheostomy.

Conditions
-----------------
Neurological Diseases, Heart or Respiratory Failure,, Sepsis, Trauma.

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 18-80 years mechanical ventilation need of percutaneous tracheostomy Exclusion Criteria: previous pathologies of upper airways or of oesophagus risk of bleeding need of FiO2 >70% and/or of PEEP >10 cm H2O difficult insertion of laryngeal mask impossibility of endoscopic visualization of the laryngeal structures

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>Short term endotracheal intubation. | |
| 2<br>Long term endotracheal intubation. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ventilatory parameters during percutaneous tracheostomy |  | Thirty minutes. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Scoring of laryngeal lesions, blood gas exchange, morbidity, mortality. |  | Thirty minutes. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Endotracheal intubation, tracheostomy, laryngeal mask
Monitoring of Delayed Ischemia After Subarachnoid Hemorrhage

Study Overview
=================
Brief Summary
-----------------
The goal in this research is to develop better ways to detect and treat the damage caused by bleeding in the brain.

Detailed Description
-----------------
Patients who suffer from a bleeding in the brain (stroke or hemorrhage) often experience secondary complications that can occur up to 2 weeks after the initial bleeding. Complications can include decrease of consciousness, weakness or paralysis, difficulty with speech and language, and worsening of brain damage. These decrease a patient's chances for a good recovery. A brain scan will be used to determine the damage caused by the bleeding, and the brain's electrical activity will be monitored to detect abnormal activity. These measures will be analyzed together with routine medical information to better understand and diagnose complications.

Official Title
-----------------
Monitoring of Delayed Ischemia After Subarachnoid Hemorrhage

Conditions
-----------------
Subarachnoid Hemorrhage

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age 18 to 70 years World Federation of Neurosurgery (WFNS) grade III-IV, and grade V patients who improve within 24h after ventriculostomy Diffuse thick or localized thick subarachnoid clot >1 mm on baseline CT (Fisher grade 3-4) Ruptured saccular aneurysm demonstrated by CT-angiography or DSA Onset of aSAH clinical symptoms within the preceding 72h Treatment of aneurysm within 24 h after admission Treatment of aneurysm by clip ligation Exclusion Criteria: SAH due to other causes (e.g. trauma, fusiform or mycotic aneurysm) Only a thin diffuse layer or no visible subarachnoid blood in the initial CT Admission in a clinical state with unfavourable prognosis (e.g., bilateral dilated, non-reactive pupils for more than 1h) Coagulopathy (thrombocytes <60,000/ml or INR>1.5) Pregnancy Presence of incompatibilities for MRI, such as non-removable metals, artificial joints, electronic devices (pace maker, pumps), etc.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Subarachnoid Hemorrhage
A Retrospective Epidemiological Study on Pneumococcal Infection in Children in Ministry of Health Hospital at EHSA Region in the Eastern Province

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to establish retrospectively the incidence rates of invasive pneumococcal disease in children aged less than 5 years. The investigators allocate the El Hasa region for the study because it has higher incidence of sickle cell anemia. The study will include data from 2003 to 2007(before introduction of the vaccine) and then for 2008 and 2009 (after introduction of the vaccine).

Detailed Description
-----------------
Data will be collected from patents files or records for 5 years before the introduction of the vaccine and for 2 years after the introduction of the vaccine. We assigned 4 doctors in each hospital to carry and supervise the work.

Official Title
-----------------
Serotyping of Pneumococci

Conditions
-----------------
Pneumococcal Infection

Intervention / Treatment
-----------------
* Biological: serotypes and resistance


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Invasive pneumococcal disease Children under 5 years Children lived in Elhasa region Exclusion Criteria: Children above 5 years No invasive pneumococcal disease

Ages Eligible for Study
-----------------
Minimum Age: 3 Months
Maximum Age: 5 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Biological: serotypes and resistance|screening patients with invasive pneumococci|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Risk factors, Case fatality, disease burden, Resistance, Benefits of pneumococcal vaccination
Motivational Enhancement Therapy to Improve Treatment Utilization in Pregnant Substance Users - 1

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to compare Motivational Enhancement Therapy (MET) with standard drug abuse treatment among pregnant women.

Official Title
-----------------
Motivational Enhancement Therapy (MET) to Improve Treatment Utilization in Pregnant Substance Users

Conditions
-----------------
Substance-Related Disorders

Intervention / Treatment
-----------------
* Behavioral: Behavior Therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pregnancy <30 weeks Have not attended drug treatment in past 28 days Not needing residential treatment (except detox) Not at risk for suicide/homicide Have no pending legal charges (except drug treatment)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Behavior Therapy|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment Utilization |  |  | 
| Substance Abuse |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
behavioral intervention
Exercise Training in a Geriatric Hospital Ward

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to describe the effects of physical exercise consisting of strength, balance and flexibility training on functional abilities and the length of stay in older (+75) patients hospitalized in a primary-care health- center hospital.

Detailed Description
-----------------
Hospitalization of older people is connected with several adverse events. Hospitalization increases the risk of disability and long-term institutionalization. Immobilization during hospitalization can lead to deterioration of muscle strength and falls. Earlier studies have shown that strength training is beneficial even in the oldest old. Rehabilitation based on strength training exercises can prevent decline in functional capacity and shorten the length of hospitalization.

Conditions
-----------------
Frail Elderly

Intervention / Treatment
-----------------
* Procedure: Exercise training
* Procedure: usual treatment and rehabilitation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: age 75 years or older ability to walk independently or assisted or move unassisted in a wheelchair Exclusion Criteria: patients in long-term care those who are bedridden severe circulatory disease acute bone fracture terminal disease acute infection.

Ages Eligible for Study
-----------------
Minimum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Group-based exercise training during hospitalization | Procedure: Exercise training<br>* Group-based exercise training 5 days a week during hospitalization<br>|
| Active Comparator: 2<br>Usual treatment and rehabilitation during hospitalization | Procedure: usual treatment and rehabilitation<br>* usual treatment and rehabilitation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in functional abilities during hospitalization |  | at the discharge from the hospital | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The length of stay in the hospital |  | at the discharge from the hospital | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Exercise Therapy, Length of Stay, Disability Evaluation