Palmitic Acid in the Sn-2 Position of Triacylglycerols and Postprandial Lipemia

Study Overview
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Brief Summary
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The purpose of this study is to determine whether high-fat meals rich in palmitic acid in the sn-2 position decrease lipaemia in men aged 40-70 y with higher than optimal fasting triacylglycerol concentrations.

Conditions
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Healthy Men, Raised Fasting Plasma Triacylglycerol Concentrations

Intervention / Treatment
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* Dietary Supplement: High-fat meal containing native palm olein
* Dietary Supplement: High-fat meal containing interesterified palm olein


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy males Non-smokers Aged 40-70 years Fasting TAG concentrations ≥1.5 mmol/L. Exclusion Criteria: Reported history of CVD (myocardial infarction, angina, venous thrombosis, stroke), impaired fasting glucose/uncontrolled type 2 diabetes (or fasting glucose ≥ 6.1 mmol/L), cancer, kidney, liver or bowel disease. Presence of gastrointestinal disorder or use of drug, which is likely to alter gastrointestinal motility or nutrient absorption. History of substance abuse or alcoholism (previous weekly alcohol intake >60 units/men) Current self-reported weekly alcohol intake exceeding 28 units Allergy or intolerance to any component of test meals Unwilling to restrict consumption of any source of fish oil for the length of the study Weight change of >3kg in preceding 2 months Body Mass Index <20 and >35 kg/m2 Fasting blood cholesterol > 7.8 mmol/L Current cigarette smoker. Current use of lipid lowering medication

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Native palm olein<br>75 g native palm olein | Dietary Supplement: High-fat meal containing native palm olein<br> <br> |
| Experimental: Interesterified palm olein<br>75 g interesterified palm olein | Dietary Supplement: High-fat meal containing interesterified palm olein<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incremental AUC (change from baseline in overall response) for plasma triacylglycerol concentrations |  | 1-6 h post-meal | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incremental AUC for plasma non-esterified fatty acid concentrations |  | 1-6 h post-meal | 
| Changes from baseline in digital volume pulse |  | 2,4,5,6 h post-meal | 
| Changes from baseline in blood pressure |  | 2,4,5,6 h post-meal | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lipemia, Vascular function, Blood pressure