CBT for Patients With Attention Deficit Hyperactivity Disorder (ADHD) and Substance Use Disorders

Study Overview
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Brief Summary
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The purpose of this study is to determine if cognitive behavioral therapy is effective in treating ADHD symptoms in patients with substance use disorders and comorbid ADHD.

Detailed Description
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Attention Deficit Hyperactivity Disorder(ADHD) is an important comorbid condition in patients with substance use disorders (SUD). The prevalence of ADHD in patients with SUD is estimated 23%, and ADHD is associated with an untoward prognosis of SUD. However, adequate treatment programs for patients with ADHD and SUD are not available. Results of medication trials for patients with ADHD and SUD are disappointing, and cognitive behavioral therapy (CBT) has not yet been investigated in this population. In patients with ADHD without comorbid SUD, the results of CBT in randomized trials are positive. The purpose of this study is to investigate if CBT is effective in treating ADHD symptoms in patients with ADHD and SUD.

Official Title
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Investigating the Efficacy of Cognitive Behavioral Therapy in Patients With Substance Use Disorder and Comorbid ADHD. A Randomized Controlled Trial With Cognitive Behavioral Therapy

Conditions
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Attention Deficit Hyperactivity Disorder, Substance Use Disorders

Intervention / Treatment
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* Behavioral: cognitive behavioral therapy for treating ADHD symptoms


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: substance use disorder ADHD able to comply with study activities Exclusion Criteria: severe neurological or psychiatric diseases (for example Parkinson, dementia, psychosis, bipolar depression) which require medication unable to read or write Dutch language

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: standard addiction treatment<br>10 sessions of standard addiction treatment. No ADHD treatment. | |
| Experimental: addiction treatment and ADHD treatment<br>10 sessions cognitive behavioral therapy on addiction treatment combined with 5 sessions on ADHD treatment. | Behavioral: cognitive behavioral therapy for treating ADHD symptoms<br>* 5 sessions of one hour CBT for treating ADHD symptoms by a trained health care worker<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| self reported ADHD symptoms | Dutch self report list of ADHD symptoms by Kooij and Buitelaar | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time Line Follow Back method | self-reported alcohol and drug use | 6 months | 
| Beck depression inventory | self reported depression symptoms | 6 months | 
| Beck Anxiety Inventory | Self reported anxiety symptoms | 6 months | 
| EQ-5 | Self reported quality of living | 6 months | 
| TIC-P | health care consumption and production loss in relation to mental health problems | 6 months | 
| Stroop task | neuropsychological measure | 6 months | 
| Tower of London task | neuropsychological task | 6 months | 
| BART task | neuropsychological task on risk taking behavior | 6 months | 
| urine checks | urine checks on drug use | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ADHD, SUD, cognitive behavioral therapy