Effects of Glucose-fructose Drinks During Training on Lactate Transport

Study Overview
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Brief Summary
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The purpose of this study is to determine whether glucose-fructose intake during training increases lactate transport and oxidation and improve endurance performance.

Detailed Description
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The study will enroll 24 healthy male volunteers. After baseline assessment of lactate transport and endurance performance, subjects will be randomized to either a 3-week intervention arm in which they will train with glucose-fructose intake during training, or to a control arm (water during training). After this 3-week intervention, lactate transport and endurance performance will be assessed again.

Official Title
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Effects of Glucose-fructose Drinks During Training on Lactate Transport and Oxidation and on Endurance Performance

Conditions
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Normal Physiology on Healthy Subjects

Intervention / Treatment
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* Dietary Supplement: Glucose-fructose
* Dietary Supplement: Water


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy age between 18 and 30 years sedentary BMI between 19 and 25 blood pressure lower than 140/90 mmHg Exclusion Criteria: smoking consumption of more than 10g alcohol per day cardiovascular history electrographic abnormalities at rest consumption of more than one can of soda per day or more than 60g sugars per day any current drug treatment consumption of drugs or illicit substances diabetes mellitus vegetarian food intolerance blood donation or participation to another study <3 months before study inclusion

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Glucose-fructose<br>Participants will take glucose-fructose drinks during training sessions | Dietary Supplement: Glucose-fructose<br>* 0.8 g/h glucose and 0.5 g/h fructose during training<br>|
| Experimental: Water<br>Participants will take only water during training sessions | Dietary Supplement: Water<br>* Only water intake during training<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in lactate transport | Measurement of lactate production, utilization, oxidation and clearance during a 90 min cycling exercise at 50% VO2 max (measured with 13C-lactate) | At baseline (before training) and after the 3-week training protocol | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in muscle monocarboxylate transporters (MCTs) expression and protein content | MCTs expression (mRNA) and protein content after muscle biopsy | At baseline (before training) and after the 3-week training protocol | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Fructose, Exercise, Lactic acid, Monocarboxylic Acid Transporters