linjc16/ctgov huggingface dataset:
Project ABLE:Advancing Better Living for Elders

Study Overview
=================
Brief Summary
-----------------
The specific aims of the study are to: 1) test the effectiveness of a home-bases intervention to improve home safety, fall efficacy and functional performance; 2) determine if the use of environmental strategies results in occurrence of less negative health events (falls and depression); 3) compare types of environmental strategies accepted and used under different treatment conditions; and 4) evaluate the cost-effectiveness of the intervention program.

Official Title
-----------------
Enhancing Function of Frail Elders At Home

Conditions
-----------------
Frail Elderly

Intervention / Treatment
-----------------
* Behavioral: Home-Based Intervention
* Behavioral: Multi-component home-based intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 70 years or older community dwelling functional vulnerability/HRCA vulnerability index= >1 problem area Exclusion Criteria: Mini-Mental Status Examination (MMSE) score of less than or equal to 23 legal blindness bed bound nursing home placement or relocation expected within 12 months of study eligibility

Ages Eligible for Study
-----------------
Minimum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Home-Based Intervention|nan|
|Behavioral: Multi-component home-based intervention|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional difficulty |  |  | 
| Fear of falling |  |  | 
| Self-efficacy |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Home hazards |  |  | 
| Control oriented strategy use |  |  | 
| Mortality |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Home modification, Occupational Therapy, Physical Therapy, Home care
A Feasibility Study Evaluating the Use of a Non-invasive Ventilation Mask

Study Overview
=================
Brief Summary
-----------------
Evaluate the clinicians assessment of the use of an oro-nasal mask during non-invasive ventilation (non-intubated) with a feasibility study.

Official Title
-----------------
Oro-nasal Mask Patient Comfort Evaluation

Conditions
-----------------
Noninvasive Ventilation, Respiratory Insufficiency

Intervention / Treatment
-----------------
* Device: Oro-nasal Mask


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patient requiring non-invasive ventilation in an intensive care unit Exclusion Criteria: patient not stable for non-invasive ventilation patient with unprotected airway excessive secretions patient with facial surgery agitated patient

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Oro-nasal mask<br>All patients are included in this arm. Patients in this group receive the experimental oro-nasal mask during non-invasive ventilation | Device: Oro-nasal Mask<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinician Assessment of Use With a Questionnaire | With the questionnaire we desired to discern the clinicians perception of use of the experimental oro-nasal mask. The questionnaire featured the ease of installation, the ease of use, and the perceived comfort of the patient. Each of the scores were on a scale from 1-5 and each were recorded to be used for individual assessment. Thus each patient has multiple assessment scores individually reported as outcomes. The clinicians were asked on a scale of 1-5 please rate their agreement with the statements The mask was easy to use. 1 strongly disagree, 2 somewhat disagree, 3 neutral, 4 somewhat agree, 5 strongly agree Your perception of patient comfort was acceptable. 1 strongly disagree, 2 somewhat disagree, 3 neutral, 4 somewhat agree, 5 strongly agree | During non-invasive ventilation with the oro-nasal mask |
Problem Solving Training and Low Vision Rehabilitation

Study Overview
=================
Brief Summary
-----------------
Vision loss can result in feelings of frustration, helplessness, anxiety, depression, and anger, which compromise a person's activities of everyday living. While emotional distress may resolve in some persons without intervention, unmanaged and persistent distress places the person at risk for continued decrements in health status and the potential development of more severe conditions (i.e., depression, poor health outcomes). Persons with low vision will be recruited and randomly assigned to either an innovative, problem-solving training (PST) intervention group designed specifically for persons with low vision or a sham intervention/control group. Primary and secondary outcomes will be assessed at baseline prior to intervention and at 3 month follow-up, 7 month follow-up, 12 month follow-up, and 24 month follow-up by a research interviewer masked to participants' randomization. This project will: (1) demonstrate how specified physical and emotional outcomes of persons with low vision change across time, (2) evaluate the effectiveness of a PST intervention that will be delivered to persons with low vision; and (3) identify persons with low vision who are at risk for adverse emotional and health outcomes.

Official Title
-----------------
Problem Solving Training and Low Vision Rehabilitation

Conditions
-----------------
Low Vision

Intervention / Treatment
-----------------
* Behavioral: problem-solving training
* Behavioral: sham intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: +19 yrs of age Underwent a low vision rehabilitation initial eye exam No more than 2 errors on cognitive on cognitive screening measure (SPBS) Must have access to telephone No significant hearing problems No significant communication problems Speaks fluent English

Ages Eligible for Study
-----------------
Minimum Age: 19 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>PST | Behavioral: problem-solving training<br> <br> |
| Sham Comparator: 2<br>Attention Control | Behavioral: sham intervention<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Center for Epidemiological Studies Depression Scale (CES-D) |  | baseline, 3months, 6 months, 12 months, 24 months |
Pressure Controlled Versus Volume Controlled Mechanical Ventilation During Anesthesia for Living Donor Liver Transplantation Recipients

Study Overview
=================
Brief Summary
-----------------
pressure controlled ventilation will improve oxygenation indices , hemodynamics during anesthesia for living donor liver transplantation recipients ,improving postoperative graft function and decreasing postoperative pulmonary complications

Conditions
-----------------
Living Donor Liver Transplantation Recipients

Intervention / Treatment
-----------------
* Device: mechanical ventilation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all living donor liver transplantation recipients scheduled Exclusion Criteria: Moderate to severe restrictive pulmonary functions
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| volume controlled<br>volume ontrolled ventilation | Device: mechanical ventilation<br> <br> |
| pressure controlled<br>pressure controlled ventilation | Device: mechanical ventilation<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| oxygen tension |  | during intraoperative period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| decreased postoperative pulmonary complications |  | one week postoperative |
Clinical Pharmacists in the Emergency Department

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate the effect of implementing clinical pharmacists in the Emergency Department Team at Randers Regional Hospital. The clinical pharmacists conduct medication history, make medical interaction screenings, -reconciliations and -reviews on unscheduled patients admitted to the Emergency Department during daytime.

Official Title
-----------------
Is Length of Stay in the Emergency Department Reduced When Clinical Pharmacists Conduct Medication History? - a Cluster Randomized Study

Conditions
-----------------
Medication Reconciliation

Intervention / Treatment
-----------------
* Procedure: Clinical pharmacists conduct medication history


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: unscheduled patients admitted to the Emergency Department at Randers Regional Hospital at weekdays during daytime (9 am to 16.15 pm) 4 or more drugs prescribed Exclusion Criteria: patients triage red patients who cannot give informed consent terminal patients patients admitted to detoxification patients refered to the acute outpatient department patients remaining in the Emergency Department overnight

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Clinical pharmacists conduct medication history | Procedure: Clinical pharmacists conduct medication history<br>* pharmacists conduct medication history before the physician interviews the patient and does not spend time on conducting medical history<br>|
| No Intervention: Control<br>standard procedures for admission is followed | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Emergency Department Length of stay |  | From arrival to the Emergency Department to either admission or discharge, which in average will be 6 hours. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time from patient arrival to the treatment schedule is ready |  | From arrival to the Emergency Department to either admission or discharge, which in average will be 6 hours. | 
| Patient safety | Number of recommended changes in drugs or dosage per patient. The changes are rated according to a PCNE-classification for drug-related problems. | From arrival to the Emergency Department to either admission or discharge, which in average will be 6 hours. | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Pharmacy, Length-of-stay, Emergency Department
A Trial to Determine the Efficacy of Near Infrared Spectroscopy to Detect Intracranial Hemorrhage in Children

Study Overview
=================
Brief Summary
-----------------
To diagnose bleeding inside the head, children need to have a CT Scan or MRI of their heads. Not all doctors order these though, especially when there is no history of injury or when children don't look too sick. Unfortunately, this means that some children's bleeding doesn't get diagnosed as early as it could. This study wants to find a way to detect bleeding inside the head without using a CT scan or MRI.

Official Title
-----------------
A Clinical Assessment of the Reliability of Near Infrared Spectroscopy for the Detection of Intracranial Hemorrhage in Young Children

Conditions
-----------------
Intracranial Hemorrhage

Intervention / Treatment
-----------------
* Device: Near Infrared Spectroscopy (NIRS)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All children under 3 years of age who undergo a CT of the head or MRI of the head. Exclusion Criteria: Lack of parental consent Neurosurgical intervention between CT/MRI and NIRS scanning. Scalp hematoma

Ages Eligible for Study
-----------------
Maximum Age: 36 Months

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: NIRS<br>Children who undergo NIRS | Device: Near Infrared Spectroscopy (NIRS)<br>* NIRS of the head is undertaken at the time of CT or MRI examination<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivity of NIRS |  | Study conclusion | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| specificity of NIRS, positive/negative predictive value |  | Study conclusion | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Near Infrared Spectroscopy, Diagnosis, Children
Genetic Variants Affecting the Clinical Severity of Beta Thalassemia

Study Overview
=================
Brief Summary
-----------------
β-thalassemia is one of the most common single gene disorder in Southern China. The phenotypic severity of beta thalassemia widely varies from mild to severe forms. Patients with the same beta thalassemia genotype show wide phenotypic variability that ranges from moderate to severe disease due to various genetic modifiers of disease severity. The aim of this study is to looking for the genetic factors which could affect the severity of beta thalassemia.

Detailed Description
-----------------
The understanding of the genotype-phenotype correlation is a very important issue to the precise diagnosis of beta thalassemia. However, the genotype-phenotype correlation of Beta thalassemia is so complex that the pathogenesis of some patients remains uncertain and cannot be explained by known mechanisms. The study of the role of the genetic variants in modulating beta thalassemia phenotype could brought us considerable novel and interesting information in this area. We will collecting more than 1000 beta thalassemia patients , analyzing their clinical data and genome data, and association study will be conducted to screen the positive genetic variants which exert a significant effect on both the HbF levels and onset ages of beta thalassemia patients.

Official Title
-----------------
Screening and Identification of Genetic Modifiers Which Affecting the Phenotype Severity of Beta Thalassemia Patients

Conditions
-----------------
Beta Thalassemia

Intervention / Treatment
-----------------
* Diagnostic Test: Hematological Analysis and Genetical Analysis


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosed with β-thalassemia Exclusion Criteria: Iron Deficiency Anemia
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| beta thalassemia patients<br> | Diagnostic Test: Hematological Analysis and Genetical Analysis<br>* Hematological Analysis: Hematological parameters were determined with an automated hematology analyzer (Sysmex, Japan), and hemoglobin analysis was performed with either high-performance liquid chromatography (Bio-Rad, USA) or capillary electrophoresis (Sebia, France and Helena, USA). Genetical Analysis: Genomic DNA was extracted from peripheral blood (PB) by using a standard phenol/chloroform method. The genotypes of samples are analyzed by NGS assay.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Genetic variants which could influence the phenotype of beta thalassemia | Identified a group of single-nucleotide polymorphisms (SNPs) that contribute to β-thalassemia | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
beta thalassemia, Hb F, Onset age, Genetic Modifier
Nutritional Evaluation of Patients With Congestive Heart Failure

Study Overview
=================
Brief Summary
-----------------
This study objective is to assess the nutritional status of Patients With Congestive Heart Failure.

Official Title
-----------------
Nutritional Evaluation of Patients With Congestive Heart Failure

Conditions
-----------------
Congestive Heart Failure

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Congestive heart failure patients between tne ages 40 to 90,all stages of the disease. Exclusion Criteria: non

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Nutritional status |  | 1.5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Congestive heart failure, Energy expenditure, Body composition, Caloric intake
Influence of G-CSF and EPO on Associative Learning and Motor Skills

Study Overview
=================
Brief Summary
-----------------
In the study we want to prove whether the subcutaneous application of granulocyte-stimulating factor (G-CSF) and erythropoetin (EPO) influence associative learning and/or motor skills of patients, who suffer from chronic stroke or amyotrophic lateral sclerosis. The study hypothesis is that G-CSF and EPO improve associative learning and/or motor skills.

Official Title
-----------------
Influence of G-CSF and EPO on Associative Learning and Motor Skills

Conditions
-----------------
Chronic Stroke, Amyotrophic Lateral Sclerosis

Intervention / Treatment
-----------------
* Drug: granulocyte - colony stimulating factor (G-CSF)
* Drug: erythropoetin (EPO)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of chronic stroke or amyotrophic lateral sclerosis Exclusion Criteria: leucocytes > 10000/µl hematocrit > 48% thrombocytes < 150000/µl severe rheumatoid arthritis severe infection severe liver or renal failure severe arterial hypertension recurrent thromboembolic events severe coronary heart disease myocardial infarction malignant tumor leukemia peripheral arterial occlusion disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: granulocyte - colony stimulating factor (G-CSF)|nan|
|Drug: erythropoetin (EPO)|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Learning success in a word learning model |  |  | 
| Response time in motor function tests |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Response time in a word learning model |  |  | 
| Total time and number of keystrokes in motor function tests |  |  |
Comparison of Two Pulse Oximeters in Delivery Room

Study Overview
=================
Brief Summary
-----------------
Time to stable reading of oxygen saturation at the delivery room will be compared between two different devices.

Detailed Description
-----------------
After delivery babies will be located in the radiant warmer. The probe of each pulse oximeter will be applied to one of the feet. Both probes will be simultaneously connected to the female plug of the pulse oximeter. Heart rate will be checked Time to get a stable reading in each device (by observation on the devices' display) will be recorded; this will be the primary study outcome. Other vital signs (oxygen saturation, heart rate) and demographics) will be recorded as well. Paired students T test will be used for the statistical analyzes.

Official Title
-----------------
Comparison of Two Pulse Oximeters in Delivery Room: A Prospective Study

Conditions
-----------------
Hypoxia

Intervention / Treatment
-----------------
* Device: Nellcor
* Device: Masimo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Neonates in the operation or delivery room immediately after delivery whose parents agreed to enter the study Exclusion Criteria: Malformation of one of the legs, not allowing sensor application. Any situation in which the study might interfere with the treatment of the newborn

Ages Eligible for Study
-----------------
Minimum Age: 1 Minute
Maximum Age: 15 Minutes

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Nellcor<br>Connection to Nellcor pulse oximeter for measuring oxygen saturation after birth | Device: Nellcor<br>* Measurement of pulse oximetry in the delivery room with Nellcor pulse oximeter<br>|
| Other: Masimo<br>Connection to Masimo pulse oximeter for measuring oxygen saturation after birth | Device: Masimo<br>* Measurement of pulse oximetry in the delivery room with Masimo pulse oximeter<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to steady reading in the pulse oximeter |  | up to 2 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Neonatal resuscitation, Pulse oximetry