Preterm Infant Multicentre Growth Study

Study Overview
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Brief Summary
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The purpose of this study is to improve health professionals understanding of preterm infant growth patterns, and to determine if early growth patterns predict risks of adverse metabolic and cognitive outcomes.

Detailed Description
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The purpose of this study is: To improve health professionals understanding of preterm infant growth patterns, and to determine if growth patterns (rapid early growth in the first 2 weeks of life, weight less than the 10th percentile at the time of discharge) predict risks of adverse metabolic outcomes (measured as overweight at age 3) once the following variables are controlled for: size at birth (z-score), neonatal morbidities, social determinants of health, and nutritional adequacy in the neonatal intensive care unit (NICU). To assess diagnostic accuracy of 36-week anthropometric weight, length and head circumference <10th and <3rd percentiles to predict preterm infant cognitive impairment.

Official Title
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Preterm Infant Multicentre Growth Study

Conditions
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Preterm Infant

Intervention / Treatment
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* Other: Growth


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: < 32 weeks gestational age at birth Exclusion Criteria: infants who had congenital anomalies or those who died prior to discharge

Ages Eligible for Study
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Maximum Age: 3 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Size < the 3rd or 10th percentiles<br>Infant size smaller than the 3rd or 10th percentiles relative to the Fenton growth chart for weight or head circumference at discharge from neonatal intensive care | Other: Growth<br>* Some preterm infants grow at higher rates than others<br>|
| Rapid early growth<br>Rapid early growth will be defined as exceeding birthweight in the first week of life | |
| Growth velocity calculation methods<br>We will compare a variety of growth velocity calculation methods used in clinical care and research to compare and assess growth velocity calculation methods | |
| Size for gestational age<br>Small size for gestational age | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Neurodevelopment | Neurodevelopment (Bayley scale scores II and III), diagnoses of cerebral palsy, or other neurologic impairments) measured | Twenty-one months of age | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Overweight | Overweight will be defined as body mass index | Three years of age | 
| Growth patterns | Growth patterns of preterm infants relative to the Fenton growth chart | From birth to 50 weeks post-menstrual age | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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weight gain, head circumference, neurodevelopment, overweight, length