Effects of Chair-Based Exercise Training on Exercise Capacity in Patients With Acute Exacerbation of COPD

Study Overview
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Brief Summary
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Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide, a respiratory disease characterized by chronic airflow limitation that is not completely reversible. Impaired pulmonary functions, decreased exercise capacity and quality of life and increased dyspnea perception is prevalent in patients with acute exacerbations of COPD.It was demonstrated exercise training has beneficial effects in patients with acute exacerbations of COPD. The purpose of this study to evaluate the effects of chair-based exercise training on exercise capacity, respiratory functions, dyspnea, balance, depression anxiety and quality of life in COPD patients in acute exacerbation.

Detailed Description
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Acute exacerbations of COPD are generally defined as events in the natural course of the disease characterized by a change in the patient's initial dyspnea, cough or sputum beyond normal daily variations. The main consequences of COPD in acute exacerbation are increased mortality, deterioration in health-related quality of life, faster decline in lung function, marked reduction in physical activity and worsening of peripheral muscle weakness, which have a direct impact on patients' health. Although exacerbations are diagnosed based on respiratory symptoms, there is evidence that they have systemic consequences, including a detrimental effect on skeletal muscle function, exercise tolerance and quality of life. Chair-based exercise training is defined as a structured and progressive exercise program applied by trainers that provides stability using a chair, which is a part of exercise training for the elderly. It is thought that it would be beneficial to study such an exercise program, since COPD patients in acute exacerbation have less mobilization during hospitalization. In a limited number of studies, some inconsistencies were observed in the exercises of patients with acute exacerbation of COPD. Studies can therefore now focus on investigating comparisons between different intervention lengths, session durations and frequencies, and intensities of exercise training. For this reason, in our planned study, we will investigate the effects of chair-based exercise training in COPD patients in acute exacerbation. There is no study in the literature investigating the effects of chair-based exercise training in COPD patients in acute exacerbation. For this reason, our study will provide important information support to the literature.

Official Title
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Comparison of the Effects of Chair-Based Exercise Training on Respiratory Functions, Exercise Capacity and Quality of Life in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Conditions
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Acute Exacerbation of COPD

Intervention / Treatment
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* Other: Treatment group, Chair-Based Exercise Training
* Other: Control group, Breathing exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who were hospitalized due to acute exacerbation of COPD Exclusion Criteria: Patients with orthopedic or neurological problems that may interfere with assessment and education, Uncooperative patients, Patients with advanced heart problems such as acute coronary syndrome, stable angina pectoris, severe arrhythmias (Atrial fibrillation etc.), decompensated heart failure.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Treatment group, Chair-Based Exercise Training<br>Treatment group will receive chair-based exercise training. Chair-based exercise training consisting of 20 different exercises will be applied in 2-3 sets with an average of 8-15 repetitions. Rest between sets will average 45-60 seconds. | Other: Treatment group, Chair-Based Exercise Training<br>* The weights of the elastic bands to be used in the exercises will be determined by the physiotherapist according to the abilities and development of the participants. The intensity of the exercise will be adjusted according to the dyspnea or fatigue patients feel according to the Modified Borg Scale. During the exercises, heart rate and oxygen saturation will be measured with a pulse oximeter, and blood pressure will be measured with a sphygmomanometer. Chair-based exercise training will be applied to the patients every day they are hospitalized.<br>|
| Other: Control group, Breathing exercise<br>Control group will receive breathing exercises. | Other: Control group, Breathing exercise<br>* Breathing exercise will be applied to the patients every day they are hospitalized.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional Exercise Capacity | Functional exercise capacity will be evaluated with 6-minute walk test. | Seven day | 
| Pulmonary Function Test | This test was evaluated using a spirometry by which is evaluated dynamic lung functions expressed as percentages of expected values. | Seven day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dyspnea | The severity of dyspnea during daily living activities is evaluated using the Modified Medical Research Council (MMRC) dyspnea scale. | Seven day | 
| One Minute Sit to Stand Test | The number of completed sit to stand repetitions in 1 minute. Patients stand/sit from a chair as many times as they can in one minute. | Seven day | 
| Timed Up and Go Test | The Timed Up and Go test is evaluated dynamic balance. | Seven day | 
| Depression and Anxiety | Evaluated using Hospital Anxiety and Depression Scale (Turkish versions of all scales) | Seven day | 
| Life of quality | Saint George's Respiratory Questionnaire (SGRQ) (Turkish versions of all scales) is used to assess the quality of life of COPD patients. | Seven day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Chair-based exercise training