IOP and Ocular Biometrics Changes After Phacoemulsification in Glaucoma Patients and Controls

Study Overview
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Brief Summary
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Effect of phacoemulsification on intraocular pressure has been studied with variable results.Furthermore, effect of phacoemulsification on ocular biometrics including anterior chamber depth and angle opening distance has also been studied. In our study we aim at establishing a quantitative relationship between preoperative ocular biometrics and postoperative intraocular pressure change and comparing this relationship in glaucomatous and non-glaucomatous eyes.

Detailed Description
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All patients will have the anterior chamber angle assessed by indentation gonioscopy preoperatively. Anterior Chamber Depth & lens thickness will be measured by Optical Biometry (lenstar 900) as well as measurement of the angle & lens vault using the Ultrasound Biomicrosopy (UBM) before and 1 month after cataract surgery. IOP will be measured pre- & postoperatively on day 7 and 30. Possible Risk (s): Risks of surgery(hemorrhage, endophthalmitis), Risks for investigations: minimal risk of infection To minimize the risk of infection: adherence to pre-& intraoperative infection-control measures, postoperative UBM is to be done at 1 month.

Official Title
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Intraocular Pressure and Ocular Biometrics Changes After Phacoemulsification in Glaucomatous Patients and Age Matched Controls, Comparative Study

Conditions
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Cataract, Glaucoma

Intervention / Treatment
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* Procedure: phacoemulsification and Intraocular lens implantation
* Diagnostic Test: Ultrasound Biomicrosopy (UBM)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 40-70 years. Glaucomtous and nonglaucomatous participants with visually significant cataracts. Best-corrected visual acuity (BCVA) equal to or worse than 6/12. patients candidates for standard cataract surgeries without adjunctive procedure (e.g., pupil stretching or iris hooks). Exclusion Criteria: Major intraoperative or postoperative complications from cataract surgery Peripheral anterior synechiae (PAS) detected by indentation gonioscopy. Uveitis, severe retinal diseases, or congenital Anomalies. History of ocular trauma or any intraocular Surgery. ocular trauma or any intraocular Surgery

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Interventional Model Description: All participants are assigned to the same interventions. All will undergo pre- & postoperative assessment, cataract surgery.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: cataract patients<br>Patients having cataract candidates for phacoemulsification with or without glaucoma are prepared to do cataract surgery with preoperative and postoperative assessment of intraocular pressure and ocular bio-metrics using UBM. | Procedure: phacoemulsification and Intraocular lens implantation<br>* Standartd surgical procedure with small incision to remove catarct using ultrasound waves. it can be done by topica, local or general anaesthesia acoording to patients general fitness and preference.<br>Diagnostic Test: Ultrasound Biomicrosopy (UBM)<br>* A diagnostic test using ultrasound waves to evaluate the anterior chamber depth, angle and lens vault.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraocular pressure change | intraocular pressure measurement by Goldman's applanation tonometr | 4 weeks | 
| ocular bio-metrics change | anterior chamber angle angle opening distance and anterior chamber depth change | 4 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Phacoemulsification as treatment to glaucoma | intraocular pressure decrease after surgery in glaucoma patients | 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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UBM, Ocular bio-metrics, Anterior chamber depth