Ketamin Plus Propofol for Anesthesia Induction

Study Overview
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Brief Summary
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ASA I-II 112 pediatric patients will recruit who underwent adenoidectomy-tonsillectomy surgery. Propofol 1 mg/kg + ketamin1 mg/kg (1/1 ratio) for group I; propofol 1,5 mg/kg + ketamin 0,75 mg/kg (2/1 ratio) for group II; propofol 2 mg/kg +ketamin 0,66 mg/kg (3/1 ratio) for group III; propofol 3 mg/kg will perform for anesthesia induction. General anesthesia will maintenance with sevoflurane 1-2% and O2/N2O mixture. Morphine 0.1mg/kg IV will be apply for postoperative analgesia at 10 min of anesthesia. Extubation time, length of stay in PACU, Watcha score, FLACC score will record. Than all data will statistically analyse.

Detailed Description
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ASA I-II 112 pediatric patients will recruit who underwent adenoidectomy-tonsillectomy surgery in this randomised controlled study. The participants will divide into the 4 groups with computered random generation. The Different combination of propofol+ketamin mixture will apply at the induction of anesthesia. The groups will assign as group I,II, III and IV. Propofol 1 mg/kg + ketamin1 mg/kg (1/1 ratio) for group I; propofol 1,5 mg/kg + ketamin 0,75 mg/kg (2/1 ratio) for group II; propofol 2 mg/kg +ketamin 0,66 mg/kg (3/1 ratio) for group III; propofol 3 mg/kg will perform for anesthesia induction. Fentanyl 1 microgram per kg and rocuronium 0.6 mg/kg will apply for anesthesia induction to the all participants. General anesthesia will maintenance with sevoflurane 1-2% and O2/N2O mixture. Morphine 0.1mg/kg IV will be apply for postoperative analgesia at 10 min of anesthesia. Extubation time, length of stay in PACU, Watcha score, FLACC score will record. Than all data will statistically analyse.

Official Title
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Effect of Ketamin+Propofol Mixture on Postoperative Recovery

Conditions
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Postoperative Recovery

Intervention / Treatment
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* Drug: Ketamine


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA I-II patients Underwent adenoidectomy-tonsillectomy surgery Age between 3-12 Exclusion Criteria: ASA III-IV patients Age; under 3 years old Age; above 12 years old.

Ages Eligible for Study
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Minimum Age: 3 Years
Maximum Age: 12 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Randomised, controlled
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Ketofol1/1<br>Propofol 1 mg/kg + ketamin1 mg/kg (1/1 ratio) for group I to anesthesia induction. | Drug: Ketamine<br>* Different mixture of ketamin-propofol will apply for anesthesia induction.<br>* Other names: ketofol;|
| Active Comparator: Ketofol1/2<br>propofol 1,5 mg/kg + ketamin 0,75 mg/kg (2/1 ratio) for group II to anesthesia induction | Drug: Ketamine<br>* Different mixture of ketamin-propofol will apply for anesthesia induction.<br>* Other names: ketofol;|
| Active Comparator: Ketofol1/3<br>propofol 2 mg/kg +ketamin 0,66 mg/kg (3/1 ratio) for group III to anesthesia induction | Drug: Ketamine<br>* Different mixture of ketamin-propofol will apply for anesthesia induction.<br>* Other names: ketofol;|
| Active Comparator: propofol<br>propofol 3 mg/kg will perform for anesthesia induction | Drug: Ketamine<br>* Different mixture of ketamin-propofol will apply for anesthesia induction.<br>* Other names: ketofol;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Delirium score | Watcha scores will record till the patient discharge from the PACU. | 30 minutes in PACU | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| length of stay in PACU | The participants will observe in PACU till the Aldrete score will achieve 15. This duration of time will record. | 30 minutes in PACU |