Mindfulness and Cognition in Schizophrenia

Study Overview
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Brief Summary
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Mindfulness (innovative and integrative practice in care) allows the individual to adapt his/her behavior (physical and emotional), in a stressful environment, by regulating cardiac activity, especially the parasympathetic system. In schizophrenia, despite the positive effect of treatments on symptoms (delusions and hallucinations), patients have altered markers of the parasympathetic (high frequency, HF) system. The investigator propose a session of Mindfulness Based Stress Reduction (MBSR) for patients suffering from schizophrenia in order to measure the impact on the parasympathetic system (HF), self-awareness (being well in one's body and being aware of their own actions; EASE) and cognition (attention) in relation to the management of conflicts or emotions. The study compare with patients who receive a session of techniques based on the management of emotions and social cognition (cinemotion, Michael's Game and Tom Remed).

Official Title
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Effect of Mindfulness (MBSR) on the Parasympathetic System and Cognition in Schizophrenia

Conditions
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Schizophrenia

Intervention / Treatment
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* Behavioral: Mindfulness


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: DSM-IV diagnosis of schizophrenia (men only) aged 18-55 with no change in antipsychotic medication and clinical status within four weeks prior to the study affiliates or entitled to a social security scheme who have given their informed consent before participating in the study. Exclusion Criteria: History of head trauma, neurological disease or not stabilized serious physical illness Disorders related to the use of a psychoactive substance, as defined by the DSM-IV (abuse, dependence or withdrawal) within 6 months Beta blocking and anti-arrhythmic medications.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Comparison between treated group or not
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Mindfulness<br>Patient will have 8 sessions (1h30) of mindfulness based on Kabat-Zinn program during one month. | Behavioral: Mindfulness<br>* Patient will have 8 sessions (1h30) of mindfulness based on Kabat-Zinn program during one month<br>|
| No Intervention: Control<br>Patient will have usual medical care. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| High Frequency spectral power | High Frequency spectral power | 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Score | Score of PANSS (POSITIVE AND NEGATIVE SYNDROME SCALE) | 2 months | 
| Score | The five facet questionnaire Mindfulness Questionary Freiburg | 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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schizophrenia, mindfulness, parasympathetic system