Japanese Phase Ib/II Copanlisib in Relapsed, Indolent B-cell NHL

Study Overview
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Brief Summary
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The primary objective of this study is to assess the safety profile of copanlisib at the recommended dose (primary endpoint). The recommended dose of copanlisib for Japanese patients will be determined in the dose escalation/safety evaluation part.

Official Title
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Open-label, Uncontrolled, Single-arm, Phase Ib/II Study of Intravenous Copanlisib in Japanese Patients With Indolent B-cell Non Hodgkin's Lymphomas Relapsed After or Refractory to Standard Therapy

Conditions
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Lymphoma Non-Hodgkin

Intervention / Treatment
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* Drug: Copanlisib (BAY80-6946)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Histologically confirmed diagnosis of indolent B-cell NHL, with histological subtype limited to the following: Follicular lymphoma (FL) grade 1-2-3a Small lymphocytic lymphoma (SLL) with absolute lymphocyte count < 5 x 109/L at the time of diagnosis and at study entry Lymphoplasmacytoid lymphoma/Waldenström macroglobulinemia (LPL/WM) Marginal zone lymphoma (MZL) (splenic, nodal, or extra-nodal) Relapsed or refractory after ≥ 2 prior lines of therapy (refractory defined as not responding to a standard regimen or progressing within 6 months of the last course of a standard regimen). Patients must have previously received rituximab and alkylating agent(s). Japanese patients ≥ 20 years of age ECOG performance status ≤ 2 (Eastern Cooperative Oncology Group:ECOG) Life expectancy of at least 3 months Adequate bone marrow, liver and renal function as assessed within 7 days before starting study treatment Left ventricular ejection fraction (LVEF) ≥ lower limit of normal (LLN) for the Institution Availability of fresh or archival tumor tissue Exclusion Criteria: Uncontrolled hypertension (blood pressure ≥ 150/90 mmHg, defined as systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 90 mmHg, despite optimal medical management) Patients with evidence or history of bleeding diathesis. Any hemorrhage or bleeding event ≥ CTCAE Grade 3 (NCI-CTC version 4.0) within 4 weeks of start of study medication (CTCAE: Common Terminology Criteria for Adverse Events, NCI: National Cancer Institute). History or concurrent condition of interstitial lung disease or severely impaired pulmonary function Unresolved toxicity higher than CTCAE grade 1 attributed to any prior therapy/procedure excluding alopecia. Prior treatment with PI3K inhibitors Systemic corticosteroid therapy (ongoing) Type I or II diabetes mellitus with HbA1c > 8.5% or fasting plasma glucose > 160 mg/dL at Screening Known history of human immunodeficiency virus (HIV) infection. Hepatitis B or C requiring treatment Cytomegalovirus (CMV) PCR positive at baseline Known lymphomatous involvement of the central nervous system

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Copanlisib (BAY80-6946)<br>Dose escalation/safety evaluation cohort and objective tumor response (OR) expansion cohort | Drug: Copanlisib (BAY80-6946)<br>* Dosing is weekly for the first 3 weeks (on Days 1, 8, and 15) of a 28-day cycle, followed by a 1-week break (i.e., no infusion on Day 22).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants with Adverse Events |  | Up to 18 months | 
| Intensity of AE | The NCI Common Terminology Criteria for Adverse Events (CTCAE, Version 4.0) will be used to assess the intensity of AE | Up to 18 months | 
| Objective Tumor Response (OR) | OR: Best response rating of complete response or partial response according to the criteria defined in the Revised Response Criteria for Malignant Lymphoma(JClin Oncol.2007 Feb) | Up to 18 Years | 
| Recommended dose determined in the dose escalation/safety evaluation |  | Up to 18 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Non Hodgkin's Lymphomas