Quality of Life in Children Glaucoma and Cataract

Study Overview
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Brief Summary
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The management of childhood glaucoma (CG), childhood cataract (CC) and other birth defects affecting the eyes requires frequent hospital attendances and often multiple surgical and medical interventions, and are often associated with poor vision. Chronic medical conditions and vision impairment can affect quality of life (QoL). The QoL of children with the above conditions has not previously been evaluated.

Detailed Description
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We wish to evaluate health related and vision related quality of life (HRQoL, VRQoL) in children age 2 to 16 years with childhood glaucoma (CG), childhood cataract (CC) and congenital eye defects microphthalmia, anophthalmia or coloboma (MAC). We will recruit children who attend the children's eye clinics at Moorfields Eye Hospital at City Road. We will include the following subgroups: A) children with primary or secondary glaucoma B) children with cataract or previously treated for cataract C) children with microphthalmia, anophthalmia or coloboma D) control group: agematched children without eye and vision problems. We will ask children and their carers to complete two age appropriate, validated questionnaires, the PedsQL (health related quality of life) and the Cardiff Visual Ability Questionnaire for Children. From the medical notes, we will record diagnosis and best corrected visual acuity with both eyes open. We will also record details of previous and current treatment, such as number of previous surgical interventions (sum of interventions right and left eye) and number of current topical medications (sum of eyedrop applications per day right and left eye).

Official Title
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Health- and Vision-Related Quality of Life in Children and Young People With Childhood Glaucoma, Childhood Cataract and Congenital Eye Defects

Conditions
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Paediatrics With Cataracts, Paediatrics With Glaucoma

Intervention / Treatment
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* Other: Quality of Life questionnaire


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: A) children with primary or secondary glaucoma B) children with cataract or previously treated for cataract C) children with microphthalmia, anophthalmia or coloboma D) control group: age-matched children without eye and vision problems Exclusion Criteria: Ocular hypertension not requiring treatment; visually not significant cataract; inability to communicate in English; surgical intervention (incisional) within one month of potential date of completing questionnaire (before or after)

Ages Eligible for Study
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Minimum Age: 2 Years
Maximum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>children with primary or secondary glaucoma | Other: Quality of Life questionnaire<br> <br> |
| 2<br>children w/ cataract or previously treated for cataract | Other: Quality of Life questionnaire<br> <br> |
| 3<br>children w/ microphthalmia, anophthalmia or coloboma | Other: Quality of Life questionnaire<br> <br> |
| control group<br>age matched children without eye and vision problems. | Other: Quality of Life questionnaire<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of babies requiring treatment for retinopathy of prematurity in the UK. | Captured in questionnaire | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Demographic characteristics of babies that need treatment, | Captured in questionnaire | 1 year | 
| Outcome of the treatment at 1 year follow up: anatomical and functional | Captured in questionnaire | 1 year | 
| Type of treatment administered | Captured in questionnaire | 1 year |