Effect of Thoracic Spine Mobilization on Sympathetic Nervous Systems

Study Overview
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Brief Summary
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This pilot study aims to i) represents the feasibility of the study design and ii) to point out acute effects of thoracic spine mobilization on skin-blood flow, erythema and the sympathetic nervous system.

Official Title
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Effect of Thoracic Spine Mobilization on Skin-blood Flow, Erythema and Sympathetic Nervous Systems

Conditions
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Erythema

Intervention / Treatment
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* Procedure: Mobilization anterior
* Procedure: Mobilization posterior


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age 20 - 30 years healthy persons Exclusion Criteria: current pain blood pressure medications osteoporosis cardiac or neurological symptoms pregnancy thromobosis

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Group A<br>Group A: immediate effects: T0, Grade 3 central thoracic mobilization from posterior-to-anterior on thoracic vertebrae from T5 to T12, immediate (T1), after 2 (T2), 4 (T3), 6 (T4), 8 (T5) and 10 (T6) minutes, 1 days wash-out period; T7, a grade 3 central thoracic mobilization from anterior-to-posterior on all thoracic vertebrae, immediate T8, after 2 (T9), 4 (T10), 6 (T11), 8 (T12) and 10 (T13) minutes. | Procedure: Mobilization anterior<br>* Participant in prone position. Central thoracic mobilization from posterior-to-anterior.<br>* Other names: Thoracic spine mobilization with anterior pressure;Procedure: Mobilization posterior<br>* Participant in sitting position. Central thoracic mobilization from anteriors-to-posterior.<br>* Other names: Thoracic spine mobilization with posterior pressure;|
| Group B<br>Group B: immediate effects: T0, 3 central thoracic mobilization from anterior-to-posterior on thoracic vertebrae from T5 to T12, immediate (T1), after 2 (T2), 4 (T3), 6 (T4), 8 (T5) and 10 (T6) minutes, 1 days wash-out period; T7, a grade 3-4 central thoracic mobilization from posterior-to-anterior on all thoracic vertebrae, immediate T8, after 2 (T9), 4 (T10), 6 (T11), 8 (T12) and 10 (T13) minutes. | Procedure: Mobilization anterior<br>* Participant in prone position. Central thoracic mobilization from posterior-to-anterior.<br>* Other names: Thoracic spine mobilization with anterior pressure;Procedure: Mobilization posterior<br>* Participant in sitting position. Central thoracic mobilization from anteriors-to-posterior.<br>* Other names: Thoracic spine mobilization with posterior pressure;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Feasibility: Adherence of recruited participants | Defined as the number of drop-outs and presence of participants which invited. Measurement unit: number | Every 4 weeks up to 2 years | 
| Feasibility of the investigating procedure | Measured the burden of testing procedure. Measurement units = number and percentage | Every 4 weeks up to 2 years | 
| Feasibility of the mobilization intervention from posterior-to-anterior on thoracic vertebrae | Measured adverse effects as pain and harm results to participants. Measurement units = number and percentage | Every 4 weeks up to 2 years | 
| Feasibility of the mobilization intervention from anterior-to-posterior on thoracic vertebrae | Measured as adverse effects as pain and harm results to participants. Measurement units = number and percentage. | Every 4 weeks up to 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of heart rate variability (HRV) | HRV is measured as the variations of the time interval between two consecutive cardiac beats registered by means Polar watch RS800 is used to measures (HRV). Measurement unit: High frequency-band (HF-Band) and Low frequency-band (LF-Band) | Change from baseline imediately after, 2, 4, 6, 8 and 10 minutes after the intervention | 
| Rate of systolic blood pressure value (mmHg) | Omron MIT Elite Plus is used for measuring systolic blood flow. iMeasurement units: mmHg (millimeter of mercury) | Change from baseline imediately after, 2, 4, 6, 8 and 10 minutes after the intervention | 
| Rate of diastolic blood pressure value (mmHg) changes | Omron MIT Elite Plus is used for measuring diastolic blood pressureMeasurement units: mmHg (millimeter of mercury) | Change from baseline imediately after, 2, 4, 6, 8 and 10 minutes after the intervention | 
| Rate of heartbeat frequency | Polar watch RS800 is used for measuring heartbeat frequency. Measurement units: beat per minute (bpm) | Change from baseline imediately after, 2, 4, 6, 8 and 10 minutes after the intervention | 
| Rate of skin-blood flow variation | Laser doppler imaging is used for measuring microcirculatory changes. Measurement units: perfusion unit | Change from baseline imediately after, 2, 4, 6, 8 and 10 minutes after the intervention | 
| Rate of erythema | Tristimulus surface colorimetry is used for measuring erythema. Measurement units: Erythema index | Change from baseline imediately after, 2, 4, 6, 8 and 10 minutes after the intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Skin blood flow, Skin redness, Sympathetic nervous system, Regional Blood Flow