Vitamin D and Outcome in Cardiac Surgery

Study Overview
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Brief Summary
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We will use a retrospective data analysis to evaluate the association of the two vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with clinical outcome in cardiac surgical patients. The occurrence of several postoperative adverse events such as myocardial infarction, low cardiac output syndrome, stroke and in-hospital death will be assessed from cardiac surgery to discharge. In addition, we will assess the association of the two vitamin D metaboolites with the duration of mechanical ventilatory support and intensive care unit stay from cardiac surgery to discharge. Moreover, in-hospital stay will be assessed according to vitamin D metabolite levels.

Detailed Description
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In a retrospective data analysis, we will evaluate the association of vitamin D metabolites (circulating 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D) with MACCE (major cardiac or cerebrovascular event) in cardiac surgical patients. The occurrence of several postoperative adverse events such as myocardial infarction, low cardiac output syndrome, stroke and in-hospital death will be assessed from cardiac surgery to discharge. Approximately 4,000 data sets from mid of 2012 until the end of 2013 will be analyzed. In all patients, we will also assess the association of vitamin D metabolite levels with the duration of mechanical ventilatory support and intensive care unit stay from cardiac surgery to discharge. Moreover, in-hospital stay will be assessed according to vitamin D status

Official Title
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25-Hydroxyvitamin D, 1,25-Dihydroxyvitamin D and Postoperative Outcome in Cardiac Surgical Patients

Conditions
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Cardiovascular Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: cardiac surgical patients aged 18 years and older Exclusion Criteria: age < 18 years heart transplant recipients pacemaker or defibrillator implantation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cardiac surgical patients<br>patients undergoing a cardiac surgical procedure | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| major cardiac or cerebrovascular event (MACCE) | MACCE is defined as in-hospital death, myocardial infarction, low cardiac output syndrome or stroke. | Patients will be followed for an average time of 14 days from cardiac surgery to discharge | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| duration of ventilatory support |  | Patients will be followed for an average time of 14 days from cardiac surgery to discharge | 
| intensive care unit stay |  | Patients will be followed for an average time of 14 days from cardiac surgery to discharge | 
| in-hospital stay |  | Patients will be followed for an average time of 14 days from cardiac surgery to discharge | 
| infection |  | Patients will be followed for an average time of 14 days from cardiac surgery to discharge | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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cerebrovascular, vitamin D, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, MACCE, mortality, cardiac