Comparison of Longitudinal Blood Pressure and Arterial Stiffness in Preeclamptic Women After Delivery

Study Overview
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Brief Summary
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The investigator measured the arterial stiffness using cardio-ankle vascular index (CAVI) test in patient with preeclampsia and normal pregnant women to evaluate the longitudinal change of CAVI and their predictors.

Detailed Description
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This study was a case control study and included 37 women with preeclampsia (PE group) and 36 normotensive women (control group) who gave birth to child at Seoul National University Bundang Hospital. Cario-ankle vasuclar index (CAVI) was measured at one day, six months and one year after delivery in both group. The investigator also checked the body weight, blood pressure, lipid profile, serum creatinine, aspartate transaminase (AST) and alanine transaminase (ALT) simultaneously with CAVI. The relationship between the presence of preelampsia and longitudinal changes of CAVI, blood pressure and metabolic indices were evaluated using generalized estimating equation (GEE) method.

Official Title
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Comparison of Longitudinal Blood Pressure and Arterial Stiffness in Preeclamptic and Normotensive Women After Delivery: One-Year Follow-Up Results

Conditions
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Preeclampsia and Eclampsia, Stiffness, Aortic, Blood Pressure

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Case group : Women who were diagnosed preeclampsia based on the criteria of the International Society for the Study of Hypertension in Pregnancy Control group : Normotensive women who gave birth to child at Seoul National University Bundang Hospital. Exclusion Criteria: Women who were hemodynamically compromised or had bleeding complication after delivery were excluded.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Preeclampsia group<br>PE was defined as diastolic BP of at least 110 mmHg on one occasion or diastolic BP of at least 90 mmHg on two consecutive occasions more than 4 hours apart, in combination with proteinuria (≥300 mg total protein in a 24-hour urine collection and, if this was not available, ≥+2 proteinuria by dipstick analysis on two consecutive occasions at least 4 hours apart) that develops after 20 weeks of gestation in previously normotensive women | |
| Control group<br>Normal pregnancy group | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The differences in longitudinal change pattern of CAVI between preeclampsia and normal pregnant women. | The CAVI was analyzed with generalized estimating equation (GEE) method to evaluate the different change pattern of CAVI between two groups. | The CAVI was measured at one day, six months and one year after delivery in both groups. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Systolic blood pressure | automated blood pressure, mmHg | one day, six months and one year after delivery | 
| Diastolic blood pressure | automated blood pressure, mmHg | one day, six months and one year after delivery | 
| Body weight | kilograms | one day, six months and one year after delivery | 
| Waist/Hip ratio | Waist circumference in centimeter, Hip circumference in centimeter, Waist/Hip Circumference Ratio is the ratio of waist circumference divided by hip circumference | one day, six months and one year after delivery | 
| Lipid profiles (Total cholesterol, TG, LDL, HDL) | mg/dL (milligrams per deciliter) | one day, six months and one year after delivery | 
| AST(aspartate aminotransferase), ALT(alanine aminotransferase) | IU/L (International Units Per Litre) | one day, six months and one year after delivery | 
| Serum creatinine | mg/dL (milligrams per deciliter) | one day, six months and one year after delivery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Preelampsia, Cardio-ankle vascular index (CAVI), Aortic stiffness, Blood pressure, LDL-cholesterol