Multi Center Case Control Study on Multiple Risk Factors of Aplastic Anemia

Study Overview
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Brief Summary
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To ascertain the risk factors of AA in ZheJiang Province of China at the moment, especially the comprehensive multiple factors risks. The author conducted a case-control research included 338 AA cases and 1464 controls. Subjects were surveyed using same standard questionnaire including personal data, past histories of diseases, family history and histories of occupational and daily exposure to harmful substances. Single and multiple Logistic regression analyses were made using SPSS17.0 on the dates to study potential factors in the development of AA.

Official Title
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Multi Center Case Control Study on Multiple Risk Factors of Aplastic Anemia Based on EDC Data Management Platform

Conditions
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Aplastic Anemia

Intervention / Treatment
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* Other: AA or not


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All the patients of AA group met a AA diagnostic criteria；The control group were chosen from other departments who were under acute infection (such as pneumonia), acute abdominal emergency (such as appendicitis), cataract surgery; 1-65 years old, male or female; Sign the informed consent. Exclusion Criteria: With myelodysplastic syndrome, leukaemia, multiple myeloma,megaloblastic anaemia, paroxysmal sleep hemoglobinuria disease blood disease, etc. History of tumor, radiation or chemotherapy, once accept the immunological therapy, autoimmune diseases or allergic disease patients; Patients with neurological diseases.

Ages Eligible for Study
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Minimum Age: 1 Year
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| AA Group<br>All the patients of AA group met a AA diagnostic criteria； | Other: AA or not<br>* to study their risk factors<br>|
| Control Group<br>The control group were chosen from other departments who were under acute infection (such as pneumonia), acute abdominal emergency (such as appendicitis), cataract surgery; | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the items about daily Exposures | Whether living or working near chemical factory or ionizing radiation, whether living in newly decorated apartments/house, having pets/livestock | January 2014 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Individual Behaviours | Smoking (daily number of cigarettes ) | January 2014 | 
| Occupational Exposures | the duration of exposure to harmful substance(including industrial glue） | January 2014 | 
| Individual Health Status | the time for the first onset of AA | January 2014 | 
| Family disease history | Whether having the same disease, other blood diseases, malignant tumor | January 2014 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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case-control study, Multiple risk factors