Effect of Colchicine On Left Ventricle Function After Anterior Myocardial Infarction Assessed By Speckle Tracking

Study Overview
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Brief Summary
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Effect of colchicine use on Left ventricles systolic function in patients with anterior S-T elevation myocardial infarction undergoing primary Percutaneous coronary intervention by using speckle tracking Echocardiography longitudinal strain pattern

Detailed Description
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The study participants are patients presented with anterior myocardial infarction. They will be divided into 2 groups. The first group will receive colchicine loading dose of 1mg then 0.5 mg maintenance dose in addition to the standard anti ischemic treatment for 6 months. The other group will only receive the standard anti ischmic treatment. Speckle tracking echocardiography will be done to all patients to assess left ventricular longitudinal strain pattern.

Official Title
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Effect of Colchicine Use On Left Ventricle Systolic Function Using Speckle Tracking Echocardiography in Patients With Anterior S-T Segment Elevation Myocardial Infarction

Conditions
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Anterior MI, Colchicine

Intervention / Treatment
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* Drug: Colchicine 0.5 mg Oral Tablet


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ▪︎Anterior S-T segment elevation myocardial infarction with time of presentation less than 12 hours. Exclusion Criteria: Severe renal impairment. Cardiac arrest. Cardiogenic shock.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Colchicine 0.5 mg oral tablet<br>100 patients presented with anterior Myocardial infarction undergoing primary Percutaneous coronary intervention will receive colchicine tablet 1mg loading dose and colchicine 0.5 mg maintance dose for 6 months and will do longitudinal strain pattern echocardiography to asses left ventricles systolic function | Drug: Colchicine 0.5 mg Oral Tablet<br>* Colchicine loading dose 1 mg and maintenance dose 0.5 mg for 6 months in addition to standard anti ischemic treatment.<br>* Other names: Standard anti ischemic treatment;|
| No Intervention: Standard anti ischemic treatment<br>100 patients presented with anterior myocardial infarction undergoing primary percutaneous coronary intervention will do longitudinal strain pattern echocardiography to asses left ventricles systolic function | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Average of global longitudinal strain pattern | Assessment of left ventricular longitudinal strain by speckle tracking echocardiography after beforr and after colchicine | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of mortality during study | Death from any cause | 6 months |