Evaluation of the Improvement of Autonomic Nervous System by a Physical Rehabilitation Program Adapted to Adulthood After Chemotherapy or Radiotherapy in Childhood

Study Overview
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Brief Summary
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Survival rate of childhood cancers is now reaching 80%. However, early or late complications related to surgery, chemotherapy and radiotherapy remain high and greatly increase the risk of late mortality. Health of individuals is closely correlated to the stability of the autonomic nervous system (ANS), a key system for maintaining homeostasis in any living species. Efficient computer tools allowed the opportunity to assess the intrinsic autonomic regulation of the ANS either directly or at a later time by an analysis of the heart rate variability (HRV). These tools have become very powerful predictors of cardiovascular morbidity and neurological aging. Physical endurance training improves both maximal aerobic capacity and ANS activity.

Detailed Description
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The main objective of this study is to evaluate improvement of ANS parameters after 6 months of adapted physical activity in adults treated for childhood cancer in Rhône-alpes region in France who have deregulation ANS or autonomic imbalance.

Official Title
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Evaluation of the Improvement of Autonomic Nervous System by a Physical Rehabilitation Program Adapted to Adulthood After Chemotherapy or Radiotherapy in Childhood

Conditions
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Cancer, Sequels, Complications

Intervention / Treatment
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* Other: Adapted physical activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Included in the SALTO_SNA study (NCT01574196) Alteration of the autonomic nervous system activity or deregulation of the sympatho-vagal balance Exclusion Criteria: Written consent form Left ventricular dysfunction

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Young adult survivors of childhood cancer<br>Adults treated for childhood cancer in Rhône-Alpes region in France between 1987 and 1992 with deregulation ANS or autonomic imbalance. | Other: Adapted physical activity<br>* The adapted physical activity is done by Education Physique et Gymnastique Volontaire (EPGV) centres.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Autonomic nervous system activity | The autonomic nervous system activity is classified in sympatho-vagal equilibrium as normal, altered or severely abnormal. For this classification, we need the values obtained for some temporal indices (Standard Deviation NN intervals (SDNN), Root Mean Square of Successive Differences (RMSSD)) and frequencies (Ptot, High Frequency (HF), Low Frequency (LF) , Very-Low Frequency (VLF), ratio LF / HF) compared to validated standards for the age (mean +/- standard deviation). | At 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Daily activity questionnaire |  | At 6 months | 
| Quality of Life Questionnaire |  | At 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Childhood cancer, Cancer, Sequels, Surgery, Complications, Chemotherapy, Radiotherapy