Accelerated Partial Breast Irradiation (APBI) Using Stereotactic Body Radiation Therapy (SBRT)

Study Overview
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Brief Summary
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This is a multi-institutional, prospective, observational registry investigating the safety and efficacy of Accelerated Partial Breast Irradiation (APBI) using a Stereotactic Body Radiation Therapy (SBRT) delivery technique that incorporates real-time image guidance, noncoplanar fields, and respiratory tracking. The study will accrue 200 patients who will be treated to a dose of 30 Gy over the course of 5 fractions. These subjects will then have a follow up time of 5 years

Detailed Description
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RADIATION TREATMENT GUIDELINES and DOSIMETRY Fiducial Placement Prior to enrollment, patients will undergo breast conservation surgery preferably with fiducial markers implanted at the time of surgery or under ultrasonic guidance25 Patients treated with gantry-based SBRT preferably will have fiducials placed at the time of surgery. For patients being treated with CyberKnife SBRT, four gold markers will be placed intraoperatively or ultrasonically to define the superior, inferior, medial, and lateral boundaries of the lumpectomy cavity in accordance with the manufacturer's (Accuray) documentation. At least three fiducials will be required for target tracking purposes to allow for rotational changes. Simulation Linear Accelerator SBRT For treatments on a gantry-based linear accelerator, patients will be positioned supine with the arms elevated. CT scans will be obtained with 1.25 mm thickness and will be acquired with free breathing as well as additional scans as needed for motion control or gating. 4DCT, MRI and PET imaging may be used to assist in determining motion estimation. CyberKnife SBRT For treatment on a robotic system, a contrast enhanced CT simulation is to be performed with 1 mm slices with the patient's arms at her sides in the supine position. The scan is to be performed with end-inspiratory breath hold from the thyroid to below the lungs. Breast immobilization devices including a vacuum mattress and a bra system will be allowed however bolus should not be used. Fiducial tracking (Synchrony) is to be used for motion tracking. DOSIMETRY Target and Organs at Risk (OAR) contours The following structures are to be contoured in all patients: Tumor cavity (GTV) as defined on CT including all fiducials implanted on CT images Clinical Target Volume (CTV) defined as the tumor cavity expanded by a uniform 15 mm margin. The CTV will not extend beyond the skin, breast or chestwall Planning Tumor Volume (PTV) for SBRT will be defined as the CTV plus 3 - 5 mm as needed at the treating physician's discretion. PTV will be limited to GTV plus 20 mm margin Skin is defined as <5 mm inside the external contour Chest wall includes the ribs and intercoastal musculature but does not include the pectoralis Heart contour begins below the level of where the pulmonary trunk branches into the left and right pulmonary arteries Lungs are to be contoured separately Spinal canal Breasts are to be contoured separately Dose Prescription The total prescribed dose to the PTV is 30 Gy delivered in 5 equal fractions of 6 Gy per day delivered on alternating days over 5 -10 total days. The prescribed dose must cover at least 95% of the PTV.

Official Title
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Accelerated Partial Breast Irradiation (APBI) Using Stereotactic Body Radiation Therapy (SBRT): a Multicenter, Observational Clinical Trial

Conditions
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Ductal Carcinoma in Situ, Invasive Ductal Carcinoma of Female Breast

Intervention / Treatment
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* Radiation: stereotactic body radiation therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Women 50 years or older Low to intermediate grade DCIS or invasive ductal carcinoma Tumor size < 2 cm invasive ductal carcinoma and < 2.5 cm DCIS Well defined lumpectomy cavity on CT Clear surgical ink margins > 2mm for invasive cancer and > 3 mm for DCIS Node negative Unifocal lesion ER and/or PR positive HER-2 negative BRCA negative Lumpectomy cavity must be < 30% of whole breast volume Exclusion Criteria: Lobular histology Angiolymphatic invasion Multiple foci of disease Lymphovascular invasion Active lupus or sarcoid Distant metastases Non-epithelial malignancies Synchronous contralateral breast cancer Grade 2 or higher oncoplastic surgery Ipsilateral pacemaker Ipsilateral breast implant Neoadjuvant chemotherapy Prior ipsilateral breast cancer or thoracic radiation Poor breast integrity Paget's Disease of the nipple Pregnant patients Severe cardiac, pulmonary, or liver diseases

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Radiation: stereotactic body radiation therapy|Treatment technique used to deliver a highly focused and accurate radiation dose to a defined target volume outside the brain; the entire course of therapy delivered in five fractions or less|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Breast Cosmesis as measured by NRG-Radiation Therapy Oncology Group (RTOG) global cosmetic score (GCS) and the Harvard Cosmesis Scale (HCS) | physician and patient assessment of breast cosmetic result following SBRT | 2-3 years | 
| Acute breast toxicity as measured by Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 | assessment of skin and breast tissue changes during and immediately following SBRT | 1-6 weeks | 
| Other late toxicities as measured by Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 | assessment of pulmonary, cardiac and chest wall changes following SBRT | 3-60 months |