Whole Body Vibration Exercise for Elderly With Cognitive Impairments

Study Overview
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Brief Summary
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The whole body vibration exercise group will have significantly more improvement in mobility, muscle strength, balance, balance confidence, and cognitive function with a lower fall rate than the control group.

Official Title
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The Effects of Whole Body Vibration Exercise Training on Physical Functioning and Falls in Community-dwelling Elderly With Cognitive Impairments

Conditions
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Dementia

Intervention / Treatment
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* Device: Whole body vibration exercise
* Behavioral: Conventional exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: a diagnosis of mild or moderate dementia, with a Clinical Dementia Rating (CDR) of 1 to 2, and a Cantonese Mini-mental State Examination (CMMSE) score at 10 or above but below the local cutoff for dementia (18-22, depending on education level) able to stand for at least 1 minute with or without hand support living in the community having an informed consent (from the primary caregiver) Exclusion Criteria: significant musculoskeletal conditions (e.g. amputations) metal implants in the lower extremity recent fracture in the lower extremity vestibular disorders peripheral vascular disease other serious illnesses or contraindications to exercise.

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Whole body vibration exercise<br>The experimental group will receive 2 sessions of whole body vibration exercise training and conventional exercise per week for a period of 9 weeks. The total duration of vibration exposure per session will range from 4 to 6 minutes. The vibration frequency and amplitude used will be 30 Hz and 1 mm, respectively. | Device: Whole body vibration exercise<br>* The whole body vibration will be delivered by a platform that can generate vibration signals (Powerplate). The total duration of vibration exposure per session will range from 4 to 6 minutes. The vibration bouts (30-45 seconds per bout) will be interspersed with a 1 to 2 minutes of rest period. While standing on the vibration platform, subjects will be instructed to repeat two exercises: (1) static semi-squats, and (2) dynamic semi-squats.<br>Behavioral: Conventional exercise<br>* The conventional exercise training will involve a combination of upper limb and lower limb stretching and strengthening exercises, balance training, and gait re-education.<br>|
| Active Comparator: Conventional exercise<br>This group will receive 2 sessions of conventional exercise training per week for a period of 9 weeks. | Behavioral: Conventional exercise<br>* The conventional exercise training will involve a combination of upper limb and lower limb stretching and strengthening exercises, balance training, and gait re-education.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Timed-up-and-go test | A measure of functional mobility | week 0 | 
| Timed-up-and-go test |  | week 9 | 
| Timed-up-and-go test |  | week 21 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Berg balance scale |  | week 0 | 
| Berg balance scale |  | week 9 | 
| Berg balance scale |  | week 21 | 
| Activities-specific balance confidence scale |  | week 0 | 
| Activities-specific balance confidence scale |  | week 9 | 
| Activities-specific balance confidence scale |  | week 21 | 
| five times sit-to-stand test |  | week 0 | 
| five times sit-to-stand test |  | week 9 | 
| five times sit-to-stand test |  | week 21 | 
| Mini-Mental State Examination |  | week 0 | 
| Mini-Mental State Examination |  | week 9 | 
| Mini-Mental State Examination |  | week 21 | 
| Quality of Life in Alzheimer's disease |  | week 0 | 
| Quality of Life in Alzheimer's disease |  | week 9 | 
| Quality of Life in Alzheimer's disease |  | week 21 | 
| incidence of falls | Incidence of falls will be recorded by using fall diaries. | daily starting from week 0 to week 33 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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rehabilitation, exercise, fall, muscle, vibration, mobility, cognition