The Efficacy of Platelets Rich Plasma for Ovarian Rejuvenation

Study Overview
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Brief Summary
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In recent years, an increased approach has appeared in the use of autologous blood products to assist tissue and organ healing. Application of platelet rich plasma (PRP) has emerged as a potential solution for infertile women with poor ovarian reserve in reproductive specialty.

Detailed Description
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Quantitative and qualitative functional improvement of ovarian function has been reported in several studies after using autologous PRP in a reproductive field. Ovarian rejuvenation, stimulating the ovaries to produce new eggs after injecting PRP, can offer hope for renewed fertility to women with poor reserve volume, advanced maternal age, or either naturally occurring or premature menopause. But, these encouraging results should be supported by several new studies. This study aimed to estimate the efficacy of trans-vaginal ovarian injection with PRP in rejuvenates ovaries in woman with poor ovarian reserve, and to assess any association of some women variables (age, menstrual status, parity, BMI) as predicting factors in success of ovarian injection with PRP.

Official Title
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The Efficacy of Platelets Rich Plasma (PRP) for Ovarian Rejuvenation

Conditions
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Infertility, Female

Intervention / Treatment
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* Other: Autologous PRP preparation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Menopause or peri-menopause under the age of 50. Premature ovarian insufficiency which is ovarian failure before the age of 40. Woman with primary ovarian failure of any cause. Exclusion Criteria: A previous injection with any medication, plasma, or PRP Invisible or difficult access ovaries. Medical disease or unfit for anesthesia patient.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 49 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Poor ovarian reserve<br>Infertile women with poor ovarian reserve | Other: Autologous PRP preparation<br>* For each patient, autologous PRP preparation havs to be injected to both ovaries and ultrasound (US) guide<br>* Other names: Plasma Rich Platelets;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Follicle-stimulating hormone (FSH) concentration | Before after intervention measurement | 4 weeks | 
| Anti-Müllerian hormone (AMH) concentration | Before after intervention measurement | 4 weeks | 
| Antral follicles numbers | Before after intervention measurement | 4 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Ovarian Rejuvenation , Infertility