The Effect of the 3/7 vs 3X9 Method in Resistance Training on Metabolic Stress in Cardiac Rehabilitation

Study Overview
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Brief Summary
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The study proposes to measure the effect of resitance training (RT) (3/7 method) on biological markers of muscle hypertrophy in a cardiac population. 3/7 method consisting of five sets of an increasing number of repetitions (3 to 7) during successive sets and brief inter-set intervals (15 s). This method is compare to 3X9 method, 3 series of 9 repetitions with inter-set (1min).The training exercise consisted of contraction on machine (leg press, triceps press, leg curl, traction, leg extension) with load of   70% of one repetition maximal (1RM). Before these trainings all subject perform HIIT on bicycles (2 min high intensity (80% Wmax) and 2 min low intensity (50% Wmax) during 30 minutes. The investigators collect blood sample before exercice, after HIIT and after RT. It is randomized cross-over study.

Detailed Description
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The subjects come on two different days minimum 2 days and maximum 10 days between the two tests. They were instructed to avoid exercise the day before they participated in the study. The investigators collect blood 2 minutes after endurance training (HIIT) and 2 min after RT training.

Official Title
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Acute Effects of the 3/7 Method and 3X9 Method in Resistance Training on Testosterone, Glucocorticoid Cortisol, Growth Hormone and Lactate in Heart Failure and Coronary Artery Disease During Cardiac Rehabilitation

Conditions
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Heart Failure, Resistance Training, Coronary Artery Disease

Intervention / Treatment
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* Other: Cardiac rehabilitation with 3/7 method
* Other: Cardiac rehabilitation with 3X9 method


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical Coronary artery diseases Heart failure with reduced ejection fraction Exclusion Criteria: angina acutely decompensated heart failure electrocardiographic evidence of ischemia significant valvular disease orthopedic/neurologic disorders that limited exercise

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CAD group<br>Coronary artery diseases | Other: Cardiac rehabilitation with 3/7 method<br>* HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3/7 method 3 rep (15 sec of rest), 4 rep (15 sec), 5 rep (15 sec), 6 rep (15 sec), 7 rep. (total volume : 25 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned.<br>* Other names: 3/7 method;Other: Cardiac rehabilitation with 3X9 method<br>* HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3X9 method 9 rep 1 minute of rest, 9 rep (1 min) and 9 rep (total volume : 27 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned<br>* Other names: 3X9 method;|
| Experimental: HFrEF group<br>Heart Failure with reduced Ejection Fraction | Other: Cardiac rehabilitation with 3/7 method<br>* HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3/7 method 3 rep (15 sec of rest), 4 rep (15 sec), 5 rep (15 sec), 6 rep (15 sec), 7 rep. (total volume : 25 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned.<br>* Other names: 3/7 method;Other: Cardiac rehabilitation with 3X9 method<br>* HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3X9 method 9 rep 1 minute of rest, 9 rep (1 min) and 9 rep (total volume : 27 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned<br>* Other names: 3X9 method;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Lactate | mmol/l | within 2 minutes after TR training session on day 1 | 
| change in Testosterone | nmol/l | within 2 minutes after TR training session on day 1 | 
| change Glucocorticoid Cortisol | nmol/l | within 2 minutes after TR training session on day 1 | 
| change in Growth Hormone | ng/ml | within 2 minutes after TR training session on day 1 | 
| change in ph | venoust | within 2 minutes after TR training session on day 1 | 
| change PCO2 venoust | mm Hg | within 2 minutes after TR training session on day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Borg scale | Borg Rating of Perceived Exertion - Borg modified (0 = no exertion at all -10 maximal exertion) | within 4 minutes after TR training session on day 1 | 
| Pleasure of the session scale | 0 = worse 10 = better | within 4 minutes after TR training session on day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cardiac rehabilition, exercise therapy, metabolic stress