Antioxidant Capacity and Vitamin A Profile in Young Adults Who Consume a Snack Bar Made From Tropical Fruits Treated With UV-C

Study Overview
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Brief Summary
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The objective of the present study was to evaluate the impact of a snack bar on some health indicators associated with diet (plasma antioxidant capacity, lipid profile, vitamin A profile (retinol and carotenoids)) and on the nutritional status (impact on energy and nutrients consumed) in a group of upper level students.

Detailed Description
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A blind randomized controlled clinical study of healthy adults, which was carried out with the approval of the ethics committee of the Centro de Investigación en Alimentación y Desarrollo, A.C. (CIAD, A.C.) with registration CE/001/2017. The intervention was carried out in a public university in Mexico from January to April 2017. Each subject signed an informed consent form. This study lasted 30 days (4 weeks), where each participant consumed daily a snack bar irradiated with UV-C. The participants were personally interviewed by the research team with a structured selection questionnaire. Thirty subjects who met the inclusion criteria were recruited, 15 of them men and 15 women. Through a simple randomization process, the participants were assigned in 3 groups of 10 people each with 5 women and 5 men, subsequently treatments (without treatment, pineapple snack bar, or mango snack bar) were randomly assigned. The outcomes between groups were analyzed with one way ANOVA, with a P-value of 0.05 or less when there was statistical significance, using statistical software. The participants, and the laboratory technicians were blinded to the treatment assignments until the conclusion of the trial.

Official Title
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Antioxidant Capacity and Vitamin A Profile in Young Adults Who Consume a Snack Bar Made From Tropical Fruits Treated With UV-C.

Conditions
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Nutritional and Metabolic Disease

Intervention / Treatment
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* Other: No Intervention
* Dietary Supplement: Pineapple snack bar
* Dietary Supplement: Mango snack bar


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Young adults of 18 years of age or older, Healthy in appearance Exclusion Criteria: People in current medical treatment Used antibiotics in past 15 days Have presented infectious symptoms on previous days Smokers Narcotic consumers Women in use of hormonal treatment Contraceptives or pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: No Intervention<br>This group did not have an intervention | Other: No Intervention<br>* This gruop did not have an intervention<br>|
| Experimental: Intervention pineapple<br>Daily consumption of 30 g of pineapple snack bar for 4 weeks. | Dietary Supplement: Pineapple snack bar<br>* 30 g daily of pineapple snack bar<br>|
| Experimental: Intervention mango<br>Daily consumption of 30 g of mango snack bar for 4 weeks. | Dietary Supplement: Mango snack bar<br>* 30 g daily of mango snack bar<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change Oxygen Radical Absorbance Capacity Assay (Antioxidant Capacity) | From baseline and thirty days post treatment | Change from baseline at thirty days | 
| Change Trolox Equivalent Antioxidant Capacity (Antioxidant Capacity) | From baseline and thirty days post treatment | Change from baseline at thirty days | 
| Change Serum Retinol Determination | From baseline and thirty days post treatment | Change from baseline at thirty days | 
| Change Serum pro-VA carotenoids | From baseline and thirty days post treatment | Change from baseline at thirty days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change Serum total polyphenols determination | From baseline and thirty days post treatment | Change from baseline at thirty days | 
| Change Serum cholesterol determination | From baseline and thirty days post treatment | Change from baseline at thirty days | 
| Change Serum Triacylglycerides determination | From baseline and thirty days post treatment | Change from baseline at thirty days | 
| Change Serum high density lipoprotein cholesterol | From baseline and thirty days post treatment | Change from baseline at thirty days | 
| Change Body Mass Index | From baseline and thirty days post treatment | Change from baseline at thirty days | 
| Change Body composition by fat-free mass index | From baseline and thirty days post treatment | Change from baseline at thirty days | 
| Change Body composition by fat mass index | From baseline and thirty days post treatment | Change from baseline at thirty days | 
| 24-hour dietary recall | From baseline and thirty days post treatment | Baseline and thirty days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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antioxidant capacity