Testicular Function After Testicular Torsion

Study Overview
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Brief Summary
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The purpose of this study is to evaluate testicular function measured as testosterone level and semen quality.

Detailed Description
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Men having undergone surgery for testicular torsion between 01.01.2003 - 12.31.2012 will receive a invitation to participate in this study. It is expected that 110 patients can be identified and about 65% of them will participate. These men will undergo a andrological evaluation, deliver a semen sample, have a blood sample taken and undergo a testicular ultrasound. Control group: Men attending the fertility counseling at Herlev hospital will be offered participation in this study. The fertility counseling demands that men who contact the clinic have never had their sperm analyzed, have not tried to get pregnant with their partner for more than a year and that they have no prior knowledge of their fertility. Primary endpoint: Semen quality measured as sperm concentration Total testosterone level Secondary endpoint: Semen parameters Semen volume (ml) Sperm concentration (x 106/ml) Sperm motility (%) (både klasse AB og ABC) sperm morphology IgA-bound spermatozoa (%) IgG-bound spermatozoa (%) Hormones FSH LH PRL Testosterone Estradiol Inhibin B Insulin-like peptide 3 SHBG Data points: Paternity Time to pregnancy Partner (yes/no) Any fertility treatment? Pain? (VAS score) Symptoms of testesterone deficiency symptoms Andrological evaluation Testicular ultrasound Testicular torsion events in the family Date of surgery Date of follow up meeting Surgery details

Official Title
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Testicular Function After Testicular Torsion

Conditions
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Testicular Torsion, Spermatic Cord Torsion

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men with a verified testicular torsion operated at Herlev and Gentofte hospital between 01.01.2003 and 12.31.2012 Exclusion Criteria: Retentio testis Varicocele Previous treatment with chemo- or radiation therapy Genetic disposition for infertility Anejculation Retrograde ejaculation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Testicular torsion group<br>Men having undergone surgery for testicular torsion between 01.01.2003 and 12.31.2012 | |
| Control group<br>Men without knowledge of their fertility status and who have never had their semen analyzed | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sperm concentration | Amount of motile sperm cells (* 10^6) | 8-17 years after surgical intervention | 
| Testosterone level | ng/ml | 8-17 years after surgical intervention | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Semen parameters as an indicator of overall testicular exocrine function | Compared with results from control group | 8-17 years after surgical intervention | 
| Hormone level as an indicator of testicular endocrine function | Follicle stimulating hormone, luteinizing hormone, prolactin, testosterone, estradiol, inhibin B, sex hormone-binding globulin, albumin | 8-17 years after surgical intervention | 
| MAR test result correlated to the type of surgery | MAR test of sperm cells | 8-17 years after surgical intervention | 
| Difference in sperm morphology and motility correlated to the type of surgery and compared to control group | Morphology and motility (%) | 8-17 years after surgical intervention | 
| Paternity as a measure of fertility | Number of kids if any. | 8-17 years after surgical intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Fertility, Testicular Torsion, Testicular function