Epicardial Fat, Visceral Fat and Coronary Atherosclerosis

Study Overview
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Brief Summary
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Background: Visceral fat is increasingly associated with metabolic syndrome and with fatty liver, a condition carrying a high risk of cardiovascular disease. The independent role of epicardial fat deposition in cardiovascular risk remains unclear.

Detailed Description
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Background: Visceral fat is increasingly associated with metabolic syndrome and with fatty liver, a condition carrying a high risk of cardiovascular disease. The independent role of epicardial fat deposition in cardiovascular risk remains unclear. Aim: Evaluate the link between epicardial fat, visceral fat, liver fat accumulation and cardiovascular diseases and carotis atherosclerosis in patients with the major cardiovascular risk factors and with or without metabolic syndrome.

Official Title
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Association Between Epicardial Fat, Visceral Fat Accumulation & Cardiovascular Atherosclerosis

Conditions
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Epicardial Fat, Visceral Fat, Atherosclerosis

Intervention / Treatment
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* Other: patient with liver fat
* Other: pts. with excess of visceral fat
* Other: control


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients referred to cardiac CT will be the source of recruitment. patients with excess of visceral fat, 30 patients with liver fat accumulation 30 sex-age-matched individual (controls) will be enrolled. All patients will undergo a complete family history, personal clinical history, physical examination and blood sampling for biochemical analysis. Informed consent will be obtained from each individual. Exclusion Criteria: subjects with severe morbid obesity (body mass index [BMI] > 40), recent history of acute illness, clinical history of ischemic heart disease and cerebrovascular disease, typical chest pain, previous coronary artery disease, conventional coronary angiography, percutaneous interventions, coronary by pass grafting, renal failure, cancer patients, subjects who take drugs that induces hepatic steatosis ( corticosteroids, estrogens, methotrexate, amiodarone and others)

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patient with liver fat<br>30 patients with liver fat | Other: patient with liver fat<br>* 30 patient with liver fat<br>|
| excess of visceral fat<br>50 pts. with excess of visceral fat | Other: pts. with excess of visceral fat<br>* pts. with excess of visceral fat<br>|
| control<br>30 control subjects | Other: control<br>* 30 control subjects<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Epicardial fat, Visceral fat, atherosclerosis, coronary computed tomography angiography, Carotid Doppler ultrasound