The Effects of Resveratrol Supplementation on Measurements of Health and Human Performance

Study Overview
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Brief Summary
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The purpose of this study is to examine the effects of resveratrol on health and human performance. The study will evaluate cognitive function and several indicators of physical health before and after taking a resveratrol supplement or a placebo for three weeks.

Detailed Description
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Measurements blood laboratory parameters cognitive assessment changes body composition changes vascular endothelial response

Official Title
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The Effects of Resveratrol Supplementation on Measurements of Health and Human Performance

Conditions
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Inflammation

Intervention / Treatment
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* Dietary Supplement: resveratrol
* Other: Placebo Comparator: Sugar Pill


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: men and women between 45 and 75 years of age Normal heart rate and Blood pressure Ability to use personal computer interface Successful completion of physical activity readiness questionnaire Exclusion Criteria: Cardiovascular disease, uncontrolled hypertension, lung disease inability to tolerate exercise have taken grape related supplement in past 12 months current use of drugs or dietary supplements to enhance exercise performance allergy to wine, grape juice or grape seed supplements

Ages Eligible for Study
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Minimum Age: 45 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Sugar Pill<br>Subject will take placebo for daily for 4 weeks, with optional additional 4 week treatment period. | Other: Placebo Comparator: Sugar Pill<br>* Subject will take placebo for daily for 4 weeks, with optional additional 4 week treatment period.<br>|
| Active Comparator: Dietary Supplement: resveratrol<br>Subject will take resveratrol supplement for 4 weeks, with optional additional 4 week treatment period. | Dietary Supplement: resveratrol<br>* Subject will take resveratrol supplement for 4 weeks, with optional additional 4 week treatment period.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vascular function | vascular response to stress will be measured using flow mediated dilation and ultrasound. | 4 weeks, with option of additional 4 week treatment period | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body fat percentage | Body fat percentage will be measured using a DEXA scan. | 4 weeks, with optional additional 4 week treatment period | 
| inflammation biomarkers | Fasting blood draw | 4 weeks, with optional additional 4 week treatment period | 
| cognitive function | cognitive function will be assessed using a validated computer based assessment tool | 4 weeks, with optional additional 4 week treatment period | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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resveratrol, insulin, inflammation, cognition, metabolism