Development of a Decision-making Aid for Referring Severe Kidney Injury Patients for Nephrology Consultations

Study Overview
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Brief Summary
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Acute kidney injury is a frequent and growing complication associated with a risk of progressing into a chronic kidney disease. Recent guidelines have recommended systematic consultations with a nephrologist 3-6 months following hospitalization. Risk factors of developing chronic kidney disease between hospital visits are understudied.

Official Title
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Development of a Decision-making Aid for Referring Severe Kidney Injury Patients for Nephrology Consultations

Conditions
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Chronic Kidney Diseases, Acute Kidney Injury

Intervention / Treatment
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* Other: monitoring for progression to chronic kidney disease


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age >18 years Suffering from acute kidney injury treated with dialysis hospitalized in a university center from August 2016 to December 2017 with severe AKI defined according to 2 of the 3 criterion definitions of KDIGO stage AKI: an increase in SCr above 354 μmol/Lor renal replacement therapy (RRT) indication, but not the 3-fold increase in SCr increase within 7 days with SCr below 354 μmol/L. The patient has been informed and does not oppose the study The patient is insured or the beneficiary of a health insurance policy Exclusion Criteria: The patients is under judicial protection or state guardianship Patient has chronic kidney disease(CKD) KDIGO stage 5 It proves impossible to give the patient clear information patients living with kidney transplant plan dialysis for bilateral surgery nephrectomy patient refuse to participate and patients with no health insurance

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with acute kidney injury<br>Requiring treatment with dialysis | Other: monitoring for progression to chronic kidney disease<br>* Collect clinical information and assess risk factors<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Develop a prognostic score of progression to chronic kidney disease at 6 months in patients requiring hospitalization for dialysis for acute kidney injury to identify those who would benefit from consultation with a nephrologist |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identify new risk factors for progression to chronic kidney disease at 6 months post dialysis for acute kidney injury pre-hospitalization and during hospitalization and day of discharge |  | 6 months | 
| Identify renal phenotype of patients with chronic kidney disease | characterization from renal biopsy | 6 months | 
| Evaluate mortality during hospital stay |  | 1 months | 
| Evaluate mortality at medium-term |  | 6 months | 
| Identify specific therapeutic interventions put into place during the 6 month consultation |  | 6 months |