Resiliency Training in Adolescents With NF1 and NF2

Study Overview
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Brief Summary
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This randomized controlled trial for resiliency training in adolescents with Neurofibromatosis 1 and Neurofibromatosis 2 via secure live video to determine the efficacy two stress and symptom management programs. Both programs are 8 week group programs.

Detailed Description
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Neurofibromatosis (NFs) are rare genetic conditions with cure. Adolescents with NF experience more symptoms of depression and anxiety, higher levels of stress associated with coping with NF symptoms, lower levels of self esteem, difficulties with social skills and social support, high rates of learning disabilities, and more pain as compared with the general population norms. The aims of this study are to compare the effect of two stress and symptom management programs tailored for adolescents with neurofibromatosis on quality of life and psychosocial functioning. We will also examine the degree to which treatment-dependent improvements in quality of life are mediated by improvements in depression, pain intensity and pain interference.

Official Title
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Resiliency Training in Adolescents With NF1 and NF2; A Randomized Controlled Trial Via Secure Live Video Conferencing to Improve Emotional, Social and Physical Function

Conditions
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Neurofibromatoses

Intervention / Treatment
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* Behavioral: Stress and Symptom Management Program 1
* Behavioral: Stress and Symptom Management Program 2


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Has a diagnosis of NF1 or NF2 and is between the ages of 12-17 Is capable of completing and fully understanding the informed consent process/assent and the study procedures and assessments in English; has parental approval for participation English speaking and at least a 3rd grade self-reported and parent reported reading level Self reported/parent reported difficulties coping with stress and NF symptoms Exclusion Criteria: Has major medical co-morbidity not NF related expected to worsen in the next 12 months Recent (within past 3 months) change in antidepressant medication Recent participation in cognitive behavioral therapy or relaxation therapy (within past 3 months) Has significant mental health diagnosis requiring immediate treatment (e.g., untreated bipolar disorder, psychotic disorder, active substance dependence) Unable or unwilling to complete assessments electronically via REDCap Unable or unwilling to participate in group videoconferencing sessions Unable or unwilling to participate along with at least 1 parent in a video screening session

Ages Eligible for Study
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Minimum Age: 12 Years
Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Stress and Symptom Management Program 1<br> | Behavioral: Stress and Symptom Management Program 1<br>* The Stress and Symptom Management Program 1 introduces and reinforces stress and symptom management for adolescents with NF. The program consists of 8 weekly 45 minute sessions, delivered through videoconferencing.<br>|
| Experimental: Stress and Symptom Management 2<br> | Behavioral: Stress and Symptom Management Program 2<br>* The Stress and Symptom Management Program 2 introduces and reinforces stress and symptom management for adolescents with NF. The program consists of 8 weekly 45 minute sessions, delivered through videoconferencing.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Physical Health Quality of Life | World Health Organization Quality of Life Brief (WHOQOL-BREF); 4-20; Higher score indicates higher QoL | 0 weeks, 8 weeks, 6 months,12 months | 
| Change in Psychological Health Quality of Life | World Health Organization Quality of Life Brief (WHOQOL-BREF); 4-20; Higher score indicates higher QoL | 0 weeks, 8 weeks, 6 months,12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Social relationships Quality of Life | World Health Organization Quality of Life Brief (WHOQOL-BREF); 4-20; Higher score indicates higher QoL | 0 weeks, 8 weeks, 6 months,12 months | 
| Environmental Quality of Life | World Health Organization Quality of Life Brief (WHOQOL-BREF); 4-20; Higher score indicates higher QoL | 0 weeks, 8 weeks, 6 months, 12 months | 
| Depression | Patient Health Questionnaire (PHQ-9) Adolescent Version; 0-27; Higher score indicates more symptoms of depression | 0 weeks, 8 weeks, 6 months, 12 months | 
| Anxiety | Generalized Anxiety Disorder (GAD-7) Questionnaire; 0-21; Higher score indicates more symptoms of anxiety | 0 weeks, 8 weeks, 6 months, 12 months | 
| Pain intensity | Numerical Rating Scale; 0-10; Higher score indicates more intense pain. | 0 weeks, 8 weeks, 6 months, 12 months | 
| Pain interference | Pain Interference Index (PII); 0-36; Higher score indicates more pain interference | 0 weeks, 8 weeks, 6 months, 12 months |