To Research the Relation Between Neonatal Morbidities and Poor Outcome in Preterm Infants

Study Overview
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Brief Summary
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From November 2014 to October 2015, a multi-centers retrospective study was conducted to collect compliance, and 8 three-level hospitals from China were included. The infants survived to a postmenstrual age of 36 week with birth weight less than 1500g and without congenital disease. The birth weight, gestational age, morbidities and poor outcomes( death, cerebral palsy, cognitive, et al) were recorded. Data were analyzed with Chi-square test to observe the relationship between morbidities and poor outcomes. And the predictive effect on the number of the top three morbidities were analyzed by Logistic regression analysis.

Official Title
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Clinical Research on the Predictive Effect of Neonatal Morbidities on the Poor Outcomes to Very Low Birth-weight and Extremely Low Birth-weight Infants

Conditions
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Preterm Infant, Morbidity;Infant, Outcome, Fatal

Intervention / Treatment
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* Diagnostic Test: Mental Development Index;Auditory Brainstem Response;okineticnystagmus


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: From November 2014 to October 2015, a multi-centers retrospective study was conducted to collect compliance, and 8 three-level hospitals from China were included. The infants survived to a postmenstrual age of 36 week with birth weight less than 1500g. Exclusion Criteria: The very low birth weight infants didn't have any congenital disease.

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 12 Months

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Bronchopulmonary Dysplasia<br> | Diagnostic Test: Mental Development Index;Auditory Brainstem Response;okineticnystagmus<br>* mental development index(MDI）<70:cognitive delay do not pass auditory brainstem response(ABR）：hearing impairment do not pass okineticnystagmus:visual impairment Patent Ductus Arteriosus<br>|
| Retinopathy<br> | Diagnostic Test: Mental Development Index;Auditory Brainstem Response;okineticnystagmus<br>* mental development index(MDI）<70:cognitive delay do not pass auditory brainstem response(ABR）：hearing impairment do not pass okineticnystagmus:visual impairment Patent Ductus Arteriosus<br>|
| Severe Retinopathy<br> | Diagnostic Test: Mental Development Index;Auditory Brainstem Response;okineticnystagmus<br>* mental development index(MDI）<70:cognitive delay do not pass auditory brainstem response(ABR）：hearing impairment do not pass okineticnystagmus:visual impairment Patent Ductus Arteriosus<br>|
| Neonatal Necrotizing Enterocolitis<br> | Diagnostic Test: Mental Development Index;Auditory Brainstem Response;okineticnystagmus<br>* mental development index(MDI）<70:cognitive delay do not pass auditory brainstem response(ABR）：hearing impairment do not pass okineticnystagmus:visual impairment Patent Ductus Arteriosus<br>|
| Brain injury<br> | Diagnostic Test: Mental Development Index;Auditory Brainstem Response;okineticnystagmus<br>* mental development index(MDI）<70:cognitive delay do not pass auditory brainstem response(ABR）：hearing impairment do not pass okineticnystagmus:visual impairment Patent Ductus Arteriosus<br>|
| sepsis<br> | Diagnostic Test: Mental Development Index;Auditory Brainstem Response;okineticnystagmus<br>* mental development index(MDI）<70:cognitive delay do not pass auditory brainstem response(ABR）：hearing impairment do not pass okineticnystagmus:visual impairment Patent Ductus Arteriosus<br>|
| Patent Ductus Arteriosus<br> | Diagnostic Test: Mental Development Index;Auditory Brainstem Response;okineticnystagmus<br>* mental development index(MDI）<70:cognitive delay do not pass auditory brainstem response(ABR）：hearing impairment do not pass okineticnystagmus:visual impairment Patent Ductus Arteriosus<br>|
| Respiratory Distress Syndrome<br> | Diagnostic Test: Mental Development Index;Auditory Brainstem Response;okineticnystagmus<br>* mental development index(MDI）<70:cognitive delay do not pass auditory brainstem response(ABR）：hearing impairment do not pass okineticnystagmus:visual impairment Patent Ductus Arteriosus<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| cognitive delay | mental development index(MDI）<70 | 1 year | 
| hearing impairment | do not pass auditory brainstem response (ABR) | 1 year | 
| visual impairment | do not pass okineticnystagmus | 1 year |