linjc16/ctgov huggingface dataset:
Prospective System Analysis of the Seasonal Influenza Virus Transmissions and Evolution in the City of Basel Basel

Study Overview
=================
Brief Summary
-----------------
The project aims to use epidemiological tools to understand the transmission and evolution of influenza viruses at an individual and population level within a small-scale city (Basel) through a combination of experimental, clinical, and mathematical advances. Investigators aim to quantitatively characterize the viral transmission using novel molecular-epidemiological tools based on whole genome sequencing.

Detailed Description
-----------------
Samples will be collected such as whole blood, serum and DNA, nasopharyngeal swamps to diagnose influenza by polymerase chain reaction (PCR) and to determine colonization rates with Staphylococcus aureus and Streptococcus pneumonia. All samples except the first naso-pharyngeal swab for influenza diagnostics will be stored in a biobank and analysed in batches. Each influenza virus isolate will be sequenced using a whole genome sequencing approach. The viral transmission and evolution will be analysed using whole genome data for a detailed molecular and phylogenetic tree analysis, respectively. The epidemiological and geographical data will be incorporated into the phylogenetic model.

Official Title
-----------------
Prospective System Analysis of Seasonal Influenza - Virus Transmission and Evolution in Basle Town

Conditions
-----------------
Influenza

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Each pediatric or adult patient, which fulfill the World Health Organization (WHO) definition of Influenza like illness. The case definition includes an acute respiratory infection with coughing, fever ≥38°C, and start of symptoms within the last 10 days. Presentation of the patient with influenza-like illness on the emergency ward of the University Hospital Basel or the University Children Hospital of both Basel or a collaborating private practise. Exclusion Criteria: - Case definition for influenza like illness is not fulfilled
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Similarity of Influenza viruses | Genomic sequencing of single virus of individual patients and comparison of genetic similarity of viruses. Grouping of patients with a same virus - this includes a range of single nucleotide polymorphisms of 0-150 differences inbetween the virus population. | at baseline |
Internal Fit Evaluation of Indirect Restorations Using Cone Beam CT (CBCT)

Study Overview
=================
Brief Summary
-----------------
this study was conducted to evaluate the internal fit of indirect restoration fabricated from CAD/CAM composite blocks versus ceramic blocks in badly broken vital teeth using cone beam CT

Detailed Description
-----------------
two parallel groups (n=42 restorations), patient having badly broken vital teeth minimum of two remaining wall will be randomly enrolled in this trial and receive restoration fabricated either from Grandio composite blocks or E-max ceramic blocks. internal fit evaluation of the fabricated restoration over their corresponding casts will be performed using cone beam CT just prior cementation of the restorations. data will be collected and statistically analyzed.

Official Title
-----------------
Internal Fit Evaluation of Indirect Restorations Fabricated From CAD/CAM Composite Blocks Versus Ceramic Blocks in Badly Broken Teeth Using Cone Beam CT (CBCT)

Conditions
-----------------
Indirect Restoration of Badly Broken Vital Teeth

Intervention / Treatment
-----------------
* Other: restoration


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with badly broken vital teeth young adult males or females (20-50 years) good oral hygeine cooperative patients approving to participate in the study Exclusion Criteria: patients with acompromised medical history severe or active periodontal disease severe medical complications lack of compliance

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: randomized clinical trial parallel group, two arms, superiority trial, allocation ratio 1:1
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: nanohybrid composite blocks<br>nanohybrid composite CAD/CAM blocks | Other: restoration<br>* indirect restoration<br>|
| Active Comparator: ceramic blocks<br>ceramic CAD/CAM blocks emax | Other: restoration<br>* indirect restoration<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| internal fit evaluation | in millimeter | on cast before delivery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
E-max CAD, composite, CAD/CAD, randomized clinical trial, internal adaptation, CAD/CAM composite restoration, all ceramic restoration, CAD/CAM milling system, inlays, onlays, cone beam CT, CBCT
One-stage Exchange Arthroplasty for Chronic Prosthetic Joint Infections

Study Overview
=================
Brief Summary
-----------------
The results found in the literature do not allow to define objectively the indications respective for a one-step or a two-step exchange of prosthetic joint. Some criteria could help to decide for one-step exchange or two-step exchange: bacteria is/are identified, profile of the bacteria, anesthetic difficulties,.. A puncture could allow to identify the bacteria involved in the prosthetic joint infection (PJI) and an antibiotherapy for a few days can be given to the patient in order to decrease the inoculum. Then, a one-step exchange can be performed. The purpose of this study is to describe the management of patients who had a pre-treatment before a one-step exchange of their prosthetic joint.

Official Title
-----------------
One-stage Exchange Arthroplasty for Chronic Prosthetic Joint Infections

Conditions
-----------------
Exchange of Prosthetic Joint, Prosthetic Joint Infection, One-step Exchange

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patient with prosthetic joint infection and having had a pre-treatment, managed at the Croix-Rousse Hospital > 18 years old Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| bacterial epidemiology | This outcome will describe the bacterial epidemiology identified with a punction, the antibiotherapy used for pre-treatment, the characteristics of patients and the PJI. | at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Treatment failure | Treatment failure is defined by local clinical and/or microbiological relapse; and/or need for additional surgery; death of septic origin | at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
pre-treatment, antibiotherapy, prosthetic joint infection, treatment failure
EPT 100: Geranium Oil for the Relief of Neuropathic Pain

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine if Geranium oil will relieve a variety of neuropathic pain and some pain relief will last more than 48 hours.

Detailed Description
-----------------
EPT 100 study is designed to identify the percentage of people who experience neuropathic pain relief from topical geranium oil from Reunion Island, determine which neuropathic pain conditions respond best and define the time course of the pain relief.

Official Title
-----------------
EPT 100: Geranium Oil for the Relief of Neuropathic Pain

Conditions
-----------------
Neuropathic Pain

Intervention / Treatment
-----------------
* Other: Geranium oil


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years of age or oler Neuralgia or neuropathy with daily pain At least moderate intensity pain Signed informed consent Exclusion Criteria: Pregnant or nursing Known allergies to geranium oil or geranium oil fractions

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Geranium oil<br> | Other: Geranium oil<br>* Daily topical application over neuropathic pain<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain relief |  | 3 times in 30 to 60 minutes post-application | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Response to therapy at 30 to 60 minutes, they will be asked to apply the oil to painful area daily |  | Daily over 1 week | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Geranium oil, Neuropathy
MBCP Safety and Performance in the Osteonecrosis of Femur Head

Study Overview
=================
Brief Summary
-----------------
The aim of this pilot study is to evaluate MBCP performance in bone regeneration after osteonecrosis biopsy of the femur head. This technic may prevent the neck of the femur bone weakness following the healthy area drilling, thanks to a bone reconstruction at the expense of the biomaterial.

Detailed Description
-----------------
Twelve patients will be enrolled in this study and evaluation of infection and inflammation of the drilled area, pain and hip function will be assessed during a one year follow up. Bone reconstruction will be evaluated with scanner and radiography.

Official Title
-----------------
Evaluation of Safety and Performance of Macroporous Biphasic Calcium Phosphate Granules Combined With Cellulosic-Derived Gel, in Filling Bones Gap After Aseptic Osteonecrosis Biopsy of Femur Head.

Conditions
-----------------
Osteonecrosis

Intervention / Treatment
-----------------
* Device: MBCP


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: femur head osteonecrosis (1 to 2 level in ARCO scale) signed informed consent Exclusion Criteria: primary bone infection femur head sphericity loss cancer, diabetes, tuberculosis previous history HIV, Hepatitis B, Hepatitis C infection drepanocytosis current corticotherapy current immunosuppressive therapy innate or acquired immune deficience pregnancy or lack of efficient contraception current participation in an other study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: MBCP|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Infection and inflammation of the drilled area (blood and clinical assessment). |  |  | 
| Adverse events. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain (Analogic Visual Scale) |  |  | 
| Hip function |  |  | 
| Bone reconstruction evaluation through scanner and radiography |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Femur head aseptic osteonecrosis, Bone reconstruction, Macroporous biphasic calcium phosphate granules
Ultrasound-guidance for Intraosseous Access During Earthquake

Study Overview
=================
Brief Summary
-----------------
The aim of this field report is to describe as the use ultrasound guidance can facilitate the insertion of intraosseous access, during the resuscitation, in the victims of out-of hospital traumatic cardiac arrest

Detailed Description
-----------------
The aim of this field report is to describe as the use ultrasound guidance can facilitate the insertion of intraosseous access, decreasing the time for drug administration and providing some benefits during the resuscitation, in the victims of out-of hospital traumatic cardiac arrest.

Official Title
-----------------
Ultrasound-guidance for Intraosseous Access Could Provide Benefits for Resuscitation in Out-of-hospital Traumatic Cardiac Arrest: a Field Report During Earthquake on Amatrice (Italy), August 24, 2016

Conditions
-----------------
Cardiac Arrest Due to Trauma (Disorder)

Intervention / Treatment
-----------------
* Device: Ultrasound guidance


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: traumatic cardiac arrest Exclusion Criteria: non traumatic cardiac arrest beheading post-mortem hypostasis carbonized bodies dismembered bodies
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Ultrasound guidance<br>The ultrasound guidance was used to establish intraosseous access | Device: Ultrasound guidance<br>* The ultrasound guidance was used to obtain intraosseous access<br>|
| Not ultrasound guidance<br>The ultrasound guidance was not used to obtain intraosseous access | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intraosseus access | The time used to esteblish the intraosseus access | up to 10 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Return of spontaneous circulation | The time to obtain the return of spontaneous circulation | up to 1 hour |
Determination of Fraction Size Equivalent Dose (FED) Levels for Intracranial Conformal Avoidance Radiotherapy

Study Overview
=================
Brief Summary
-----------------
The primary objective is to evaluate and quantify the reproducibility of functional magnetic resonance imaging (fMRI) maps of the eloquent brain areas corresponding to specific neurological functions based on activation maps obtained with different thresholds in patients with benign and biopsy proven low-grade brain neoplasms. Another objective is to access the impairment in neurological function in image guided intracranial radiotherapy using neurocognitive assessment tools and to derive dose response curves relating the impairment in a particular neurological function to the FED received by the area of eloquent brain corresponding to it.

Official Title
-----------------
Determination of Fraction Size Equivalent Dose (FED) Levels for Intracranial Conformal Avoidance Radiotherapy

Conditions
-----------------
Glioma, Brain Neoplasms

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Indication for brain radiotherapy. Ability to undergo MRI scans and time to participate in neurocognitive testing.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients<br>patients who will receive XRT | |
| matched volunteers<br>Spouse or sibling | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
low grade gliomas and benign CNS lesions
Musculoskeletal Problems During Pregnancy

Study Overview
=================
Brief Summary
-----------------
Aim: This study was conducted to identify the most common musculoskeletal problems according to trimester, experienced by pregnant women. Material and Methods: A total of 120 pregnant women who admitted to physical medicine and rehabilitation clinic, evaluated retrospectively in this study. Application complaints, the diagnosis and the trimester of the pregnant women and also age, weight, height, number of pregnancy, working status, presence of secondary disease were recorded.

Official Title
-----------------
Musculoskeletal Problems During Pregnancy

Conditions
-----------------
Most Common Musculoskeletal Problems in Pregnancy

Intervention / Treatment
-----------------
* Other: No intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pregnant patients who have age, weight, size, employment status, duration of pregnancy, nulli/multi-parity, presence of other disorders, application complaints, the diagnosis information were included to the study Exclusion Criteria: Non-pregnant patients and pregnant patients with missing data were excluded from the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: No intervention|No intervention, it is retrospective study.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Application complaints | such as pain, numbness, tingling, swelling and cramps… | 1 day | 
| the diagnosis | low back pain, pelvic girdle pain, carpal tunnel syndrome, pedal edema, cramp, knee pain, foot pain, neck pain… | 1 day | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
carpal tunnel syndrome, low back pain, pelvic girdle pain
Promoting Cervical Cancer Screening for Emergency Department Patients

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to learn methods to encourage women to get recommended cervical cancer screening. Cervical cancer screening is an important part of cervical cancer prevention. The study team will determine if the patient is currently up-to-date with cervical cancer screening recommendations. If the patient is not up-to-date, then they will be randomly assigned to one of two interventions. One intervention consists only of referral to a women's health care provider to obtain cervical cancer screening. The other intervention consists of receiving a total of 3 text messages at 30-day intervals encouraging follow-up for cervical cancer screening.

Official Title
-----------------
Piloting Interventions to Improve Adherence to Cervical Cancer Screening Recommendations Among Emergency Department Patients

Conditions
-----------------
Cervical Cancer

Intervention / Treatment
-----------------
* Behavioral: Provider Referral
* Behavioral: Text Messaging


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Registered patient in the Emergency Department of the University of Rochester Medical Center Women Age 21 - 65 Exclusion Criteria: Past hysterectomy with cervical removal Known infection with HIV (screening recommendations for women with HIV differ from the general population) Non-English speaking Inability to consent Lack of text-capable mobile phone and/or inability to use text function

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: screening and referral<br> | Behavioral: Provider Referral<br>* Participants will be asked if they are up-to-date on their cervical cancer screening. If not they will be referred to a provider. At the end of the study they will receive a 10 minute follow up telephone survey to collect data screening status and views on cervical cancer screening.<br>|
| Active Comparator: behavioral intervention<br> | Behavioral: Text Messaging<br>* Participants will be asked if they are up-to-date on their cervical cancer screening. If not they will be referred to a provider. They will also receive a total of 3 text messages at 30-day intervals encouraging follow-up for cervical cancer screening. They will receive a 10 minute follow up telephone survey to collect data screening status and views on cervical cancer screening.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of participants who scheduled or completed cervical cancer screening |  | 150 days |