The Correlation Between Testosterone and Cortisol Level and Inflammatory Markers Levels in Type 2 Diabetic Men.

Study Overview
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Brief Summary
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Many type 2 diabetic men have low serum testosterone levels. Our aim in this trial is to check if there is a correlation between serum or hair testosteron levels and serum or hair cortisol levels in type 2 diabetic men. We'll also examine whether there is a correlation between serum and hair testosterone levels and cortisol levels and serum inflammatory markers. If such correlation will be found- then it is possible that excess cortisol or an abnormal inflammatory status- may cause the low testosterone levels that seen in type 2 diabetic men.

Detailed Description
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Eligible participants are type 2 diabetic men who visit our clinic, as part of their routine medical surveillance, and other 10 healthy volunteers (men) as a control group. All the participants will sign an informed consent form. The study will include 30 type 2 diabetic men, (40-55 years old) and 10 healthily volunteers (same age group). In addition to routine blood test of blood count, kidney function and liver enzymes will be taken blood samples of total testosterone serum levels, total cortisol serum levels and serum inflammation markers levels, and also a sample of head-hair for cortisol and testosterone levels (1 cm of occipital hair weighing 50 mg). Optional: from patients who will agree to visit the clinic after 8 hours-fast will be also taken one additional blood sample of fasting glucose, insulin and C-peptide levels, in order to estimate their insulin resistance status, and it's possible correlation to the other measures. From the 10 healthy volunteers In addition will be taken blood and hair samples of the above parameters, as a control.

Official Title
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The Correlation Between Testosterone and Cortisol Level and Inflammatory Markers Levels in Type 2 Diabetic Men.

Conditions
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Type 2 Diabetic

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: men age 40-55 type 2 diabetic Exclusion Criteria: HIV septic disease

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| two parallel group<br>group with inflammatory markers high levels and control group with inflammatory normal levels markers. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Testosterone level | single blood and hair sample will be drawn to measure Testosterone levels (nmol/L) | 24 months | 
| Cortisol level | single blood and hair sample will be drawn to measure cortisol levels (mcg/dl) | 24 months | 
| C-reactive protein levels | single blood sample will be drawn to measure c-reactive protein levels (mcg/dl) | 24 months | 
| Anti Tumor Necrosis Factor alpha | single blood sample will be drawn to measure Anti Tumor Necrosis Factor alpha levels (pg/ml) | 24 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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men