linjc16/ctgov huggingface dataset:
Comparative Evaluation of Various Combinable Magnetic Resonance (CMR) Pulse-sequences for Macrophage Imaging Using Ferucarbotran

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to: clarify whether macrophage imaging using ferucarbotran is able to delineate the region of myocardial infarction as accurate as gadolinium-based necrosis/fibrosis imaging; identify possible differences in infarct imaging using ferucarbotran for macrophage imaging compared to necrosis/fibrosis imaging with gadolinium-based compounds; and evaluate which MRI pulse-sequences maximise sensitivity for macrophage imaging with ferucarbotran in the setting of acute myocardial infarction.

Official Title
-----------------
Comparative Evaluation of Various CMR Pulse-Sequences for Macrophage Imaging Using Ferucarbotran as Molecular Contrast Agent in Human Myocardial Infarction

Conditions
-----------------
Acute Myocardial Infarction

Intervention / Treatment
-----------------
* Drug: Ferucarbotran (Resovist)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: acute myocardial infarction (STEMI or NSTEMI) Exclusion Criteria: contraindication to CMR or Magnevist® or Resovist®

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Ferucarbotran<br> | Drug: Ferucarbotran (Resovist)<br>* single time intravenous bolus injection of a contrast agent<br>* Other names: Resovist;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Extent of myocardial infarction (as demonstrated with gadolinium-based necrosis/ fibrosis imaging compared to macrophage imaging using ferucarbotran) |  | within 5 - 15 days after myocardial infarction |
Safety and Efficacy of Using GlucoSat Technology For Non-Invasive Glucose Measurement

Study Overview
=================
Brief Summary
-----------------
This study is a prospective, open label, controlled, single center study. 40 patients will be recruited for the study, according to patients' inflow and meeting eligibility criteria. Primary Goal * To evaluate the safety of the GlucoSat technology as a non-invasive blood glucose level measurement technology. Secondary Goal * To assess the efficacy of the GlucoSat technology as a non-invasive blood glucose level measurement technology.

Detailed Description
-----------------
Primary Endpoint Parameter • Primary study endpoint will be to establish the safety of using the GlucoSat technology as a non-invasive glucose level measurement technology. Safety will be established by paucity of adverse events. Adverse Events occurrence will be documented throughout the study. Secondary Endpoint Parameters Efficacy of the GlucoSat technology will be assessed by: Proving the accuracy and precision of the GlucoSat technology by comparing the glucose level measured by the GlucoSat device to the glucose level observed by any certified for clinics invasive device. Inter device variability should be within 15%. Patient satisfaction questionnaire. Physician satisfaction will be assessed by questionnaire.

Official Title
-----------------
Safety and Efficacy of Using GlucoSat Technology For Non-Invasive Glucose Measurement

Conditions
-----------------
Diabetes

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Male/Female aged 18 and up. Subject was diagnosed as a diabetes patient or healthy subject. Subject able to comprehend and give informed consent for participation in this study. Signed Informed Consent Form Exclusion Criteria: Pregnancy or breast feeding. Patients treated with steroid. Concomitant Coumadin use Recent (within the last 3 months) myocardial infarction or CVA (stroke). Any chronic unstable disease within the last 3 months. Acute bleeding disorders. HIV positive. Hepatitis B/C positive. BMI>37 Needing emergency surgery Known cognitive or psychiatric disorder Physician objection Concurrent participation in any other clinical trial

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Efficacy of Shoulder Mobilisation Versus Conventional Immobilisation for Nonsurgically Proximal Humerus Fracture

Study Overview
=================
Brief Summary
-----------------
Background: Nonsurgical proximal humerus fracture is common, causing prolonged disability, for which the time to begin rehabilitation is not well determined. We assessed the feasibility and efficacy of early (within 3 days'after fracture) mobilisation of the shoulder compared with conventional 3-week immobilization followed by physiotherapy.

Detailed Description
-----------------
Methods: We randomly assigned 74 patients with impacted nonsurgically treated proximal humerus fracture to receive early passive mobilisation or conventional-treatment. The primary outcome was functional assessment of the shoulder (Constant score) at 3 months. Secondary outcomes were functional assessment at 6 weeks and at 6 months, change in pain (on a visual analogue scale) and passive range of motion.

Official Title
-----------------
Effectiveness at 3 Months of Immediate Shoulder Mobilisation Versus Conventional Immobilisation for Impacted Nonsurgically Treated Proximal Humerus Fracture: a Randomised Controlled Trial.

Conditions
-----------------
Shoulder Fracture

Intervention / Treatment
-----------------
* Procedure: mobilisation (rehabilitation)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Impacted nonsurgically treated proximal humerus fracture Patients over the age 20 Exclusion Criteria: Pre-existing shoulder pathology Neurological disorders of the upper limbs Indication for surgery of the shoulder Combined polytrauma Difficulties with language or comprehension to understand a rehabilitation program and information

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: mobilisation (rehabilitation)|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The primary outcome was functional assessment of the shoulder (Constant score) at 3 months. |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Functional assessment at 6 weeks and at 6 months |  |  | 
| Change in pain (on a visual analogue scale)at 6 weeks, 3 months and at 6 months |  |  | 
| Passive range of motion at 6 weeks, 3 months and at 6 months. |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Nonsurgical proximal humerus fracture, Rehabilitation, Physiotherapy, randomised controlled trial
Obese Patients With or Without Comorbidities (RIO-North America)

Study Overview
=================
Brief Summary
-----------------
To assess the effects of weight loss and weight maintenance over a period of two years when prescribed with a hypocaloric diet in obese patients with or without comorbidities

Official Title
-----------------
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Fixed-Dose, Multicenter Study of Weight-Reducing and Prevention of Weight Regain Effects and Safety in Obese Patients With or Without Comorbidities

Conditions
-----------------
Obesity, Weight Loss

Intervention / Treatment
-----------------
* Drug: Rimonabant (SR141716)


Participation Criteria
=================
Eligibility Criteria
-----------------
Stable weight (variation of less than 5 kg within 3 months prior to screening visit) BMI (Body Mass Index) of 30 or greater in patients with or without comorbidities, or BMI greater than 27 in patients with treated or untreated hypertension and/or treated or untreated dyslipidemia

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Rimonabant (SR141716)|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in body weight |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Metabolic parameters |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Weight Loss, Obesity, Weight Reduction, Overweight
Assessment of the Psychological, Cognitive and Social Resources of Applicants for Huntington's Disease and Presymptomatic Genetic Testing

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess the psychological, cognitive and social resources of applicants for Huntington's Disease and Presymptomatic Testing.

Conditions
-----------------
Presymptomatic Huntington Disease

Intervention / Treatment
-----------------
* Behavioral: psychological interview
* Radiation: MRI
* Other: cognitive tests
* Other: neurological tests


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Applicants for Huntington's Disease and Presymptomatic Testing Aged 18 years and above Huntington disease family member Subject gave its written consent Exclusion Criteria: No national health insurance affiliation Being under guardianship Meeting brain MRI exclusion criteria (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin, or body, Renal failure, hypersensitivity of Gadolinium) or refusing MRI. Patient with movement disorder

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: All subjects<br>psychological interview, MRI, neurological tests, cognitive tests | Behavioral: psychological interview<br> <br> Radiation: MRI<br>* This MRI is a specific intervention assign to the subjects of the study, that's why it is an interventionnal study<br>Other: cognitive tests<br> <br> Other: neurological tests<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from baseline total score of the psychological Unified Huntington's Disease Rating Scale at 2 years |  | 3 months before diagnostic (baseline) ; 2 years after diagnostic, |
Implementation of Rehabilitation Program for Post COVID-19

Study Overview
=================
Brief Summary
-----------------
Many people who have suffered from the effects of this disease might now be at risk of long-term impairment and disability. The extent of this impairment and disability is yet unknown, but it is clear from early research that these patients will be in need of rehabilitation in all phases of the disease - acute, post-acute and long-term. Rehabilitation is defined as a set of interventions designed to reduce disability and optimize functioning in individuals with health conditions in interaction with their environment. Rehabilitation might very well be a key strategy to reduce the impact of COVID-19 on the health and function of people. A team work is needed to implement this programs which are essential in all phases to facilitate early discharge, but even more to support and empower patients.

Official Title
-----------------
The Effect of Implementing a Nursing Program Intervention on Improvement of Health Quality of Post Covid-19 Patients

Conditions
-----------------
Post COVID-19 Syndrome, Rehabilitation

Intervention / Treatment
-----------------
* Behavioral: Rehabilitation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Post acute COVID-19 patients Exclusion Criteria: Acute COVID-10 Non- COVID-19 patients Recent myocardial infarction Recent pulmonary embolism Neurologic diseases

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Rehabilitation|Rehabilitation program|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Optimizing health and functioning outcomes | decrease intensive care acquired weakness | 6 months | 
| improve recovery and reduce disability | decrease dyspnea, fatigue, anxiety and sleep disturbance | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
nursing program, health quality of life
The Impact of African American Women's Hair Care Practices and Hair Attitudes on Exercise Habits

Study Overview
=================
Brief Summary
-----------------
The purpose of this research study is to better understand African American women's hair and hair styling practices and how these practices affect attitudes and viewpoints regarding exercise.

Official Title
-----------------
The Impact of African American Women's Hair Care Practices and Hair Attitudes on Exercise Habits

Conditions
-----------------
Hair and Scalp Health

Intervention / Treatment
-----------------
* Other: Survey of exercise practices


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Female between 21 and 60 years old. African, Afro-Caribbean, or African American decent. Able and willing to follow study procedures and successfully complete hair and exercise questionnaire/survey. Exclusion Criteria: Unable to read or understand hair and exercise questionnaire/survey.

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| 1<br>African American females between the ages of 21 and 60 | Other: Survey of exercise practices<br>* detailed questionnaire regarding the subject's race, income level; type(s), frequency, intensity, and amount of exercise; attitudes about exercise; hair style; hair care practices; attitudes about hair; hair and scalp health; and attitudes about exercise with regards to hair<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
African American females between the ages of 21 and 60
AYA STEPS RCT: AYA Self-Management Via Texting, Education & Plans for Survivors

Study Overview
=================
Brief Summary
-----------------
The proposed project will leverage two programs of research at UPenn and CHOP that are delivering technology-based interventions to adolescent and young adult (AYA) cancer survivors. In the proposed study, all AYA survivors will receive a care plan via a tool (Smart-ALACC). They will then be randomized to receive (or not) a mobile health application (AYA STEPS) that will provide tailored messages to enhance uptake of their care plan.

Official Title
-----------------
AYA STEPS RCT: AYA Self-Management Via Texting, Education & Plans for Survivors

Conditions
-----------------
Adolescent and Young Adult (AYA) Cancer Survivors

Intervention / Treatment
-----------------
* Other: AYA STEPS


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: AYA is 15-29 year old with a history of a malignant cancer diagnosis; Completed cancer treatment and are currently in remission or receiving cancer survivorship care; Seen for follow-up oncology care at CHOP or Penn; For AYA less than 18 years old, must have a caregiver to provide informed consent. Exclusion Criteria: Cognitive impairments that would limit AYA ability to independently care for health as determined by the medical team. Absence of the inclusion criteria

Ages Eligible for Study
-----------------
Minimum Age: 15 Years
Maximum Age: 29 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: AYA STEPS|a mobile health application|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Completed mobile data and questionnaires |  | 10 years |
Effect of Metal Skin Sensitivity on Restenosis After Stent Implantation

Study Overview
=================
Brief Summary
-----------------
This trial is intended to find wether there is a connection between allergy to metals and reooclusion of stents in the coronary arteries

Official Title
-----------------
Rate of Metal Skin Allergy in Cohorts of Patients With and Without Coronary Stent Restenosis

Conditions
-----------------
Coronary Stent Restenosis

Intervention / Treatment
-----------------
* Procedure: skin sensitivity test


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with 2 cardiac catheterization in one years time and in the first one stent implantation Exclusion Criteria: None

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: skin sensitivity test|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The rate of skin delayed type hypersensitivity to metals among patients with restenosis and without restenosis |  |  | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Restenosis, skin metal allergy
A Comparison Study of Treatments Given to Patients With Concurrent Eating Disorder and Personality Disorder.

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to determine whether in-patient treatment is better then intensive out-patient group treatment for patients with concurrent eating disorder and personality disorder.

Detailed Description
-----------------
The main aim of the study is to compare the effects of in-patient treatment with a group based intensive out-patient treatment. It is a randomized controlled comparison study including patients with concurrent eating disorder and personality disorder. 18 patients will receive an in-patient treatment lasting one year. 18 patients will receive intensive out-patient treatment consisting of two-weekly group sessions, lasting one year. Personality disorder, eating behavior, symptoms, and function will be followed for two years.

Official Title
-----------------
Treatment of Patients With Concurrent Eating Disorder and Personality Disorder: A Controlled Randomized Comparison Study, of Treatments Given to In-patients and Out-patients.

Conditions
-----------------
Eating Disorder, Anorexia Nervosa, Bulimia Nervosa, Personality Disorder

Intervention / Treatment
-----------------
* Behavioral: inpatient treatment
* Behavioral: outpatient treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Anorexia nervosa, bulimia nervosa, personality disorder. Exclusion Criteria: male, schizophrenia.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: inpatient treatment<br>inpatient treatment during 1 year | Behavioral: inpatient treatment<br>* inpatient treatment during 1 year<br>|
| Active Comparator: outpatient treatment<br>intensive outpatient treatment consisting of two-weekly group sessions during 1 year | Behavioral: outpatient treatment<br>* intensive outpatient treatment consisting of two-weekly group sessions during 1 year<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Score on personality, interpersonal, eating disorder and symptom scales |  | 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Eating disorders, Anorexia nervosa, Bulimia nervosa, Personality disorders, In-patient treatment, out-patient treatment, group therapy