Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

Study Overview
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Brief Summary
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RATIONALE: Hepatic arterial infusion uses a catheter to carry tumor-killing substances directly into the liver. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving floxuridine and dexamethasone directly into the arteries around the tumor together with combination chemotherapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well hepatic arterial infusion with floxuridine and dexamethasone works when given together with combination chemotherapy in treating patients with colorectal cancer that has spread to the liver.

Detailed Description
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OBJECTIVES: Primary Assess the rate of conversion to complete resection in patients with initially unresectable colorectal cancer metastatic to the liver treated with hepatic arterial infusion comprising floxuridine and dexamethasone in combination with systemic irinotecan hydrochloride and either oxaliplatin or leucovorin calcium/fluorouracil. Secondary Evaluate the time to progression in patients treated with this regimen. Evaluate disease-free survival of patients treated with this regimen. Evaluate overall survival of patients treated with this regimen. Determine the response rate (complete, partial, and moderate response) in patients treated with this regimen. Evaluate the safety profile and tolerability of this regimen in these patients. Assess the expression pattern of the VEGF receptor VEGFR1, VEGFR2, and VEGFR3 and their cognate ligands (i.e., VEGF-A, VEGF-B, VEGF-C, VEGF-D, and P1GF) in patients treated with this regimen. Correlate circulating angiogenic markers with tumor resectability, disease progression, and patient survival. Procure normal and diseased liver tissue for evaluation of thymidylate synthase, p53 gene, p21, topoisomerase 1, dihydropyrimidine dehydrogenase, and excision repair cross-complementing gene levels. Assess the expression pattern of tissue factor (TF) and explore its correlation with the TF receptors PAR-1, PAR-2, TF regulators PTEN, k-ras, b- raf, p53, and outcome.(Closed as of 11/30/10) Assess the prognostic and predictive role of preoperative, pretreatment, and during treatment serum TF in regards to outcome (progression-free survival and overall survival) and response to treatment with this regimen and to salvage treatments such as EGFR-inhibitors.(Closed as of 11/30/10) OUTLINE: This is an open-label, nonrandomized study. Patients are assigned to 1 of 2 treatment groups according to receipt of more than 2 prior courses of oxaliplatin (no vs yes). Group 1 (no more than 2 prior courses of oxaliplatin): Patients receive hepatic arterial infusion (HAI) therapy comprising floxuridine and dexamethasone continuously on days 1-14. Patients also receive oxaliplatin IV over 2 hours and irinotecan hydrochloride IV over 30 minutes on days 1 and 15. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. Group 2 (more than 2 prior courses of oxaliplatin): Patients receive HAI therapy as in group 1. Patients also receive irinotecan hydrochloride IV over 30 minutes and leucovorin calcium IV over 30 minutes on days 1 and 15 and fluorouracil IV continuously over 48 hours on days 1, 2, 15, and 16. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. In both groups, patients may undergo complete resection of liver metastases after completion of at least 3 courses of therapy. Some patients undergo blood and tissue collection periodically for correlative and immunological studies. Samples are analyzed for VEGF receptor VEGFR1, VEGFR2, VEGFR3, thymidylate synthase, p53, p21, topoisomerase 1, dihydropyrimidine dehydrogenase, and excision repair cross-complementing gene levels. After completion of study treatment, patients are followed every 3 months for 2 years, every 4 months for 3 years, and then annually thereafter.

Official Title
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A Phase II Study of the Rate of Conversion to Complete Resection in Patients With Initially Inoperable Hepatic-Only Metastases From Colorectal Cancer After Treatment With Hepatic Arterial Infusion With Floxuridine and Dexamethasone in Combination With Best Systemic Chemotherapy

Conditions
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Colorectal Cancer, Metastatic Cancer

Intervention / Treatment
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* Drug: dexamethasone
* Drug: floxuridine
* Drug: fluorouracil
* Drug: irinotecan hydrochloride
* Drug: leucovorin calcium
* Drug: oxaliplatin


Participation Criteria
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Eligibility Criteria
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DISEASE CHARACTERISTICS: Histologically confirmed colorectal adenocarcinoma metastatic to the liver Previously treated or untreated disease No clinical or radiographic evidence of extrahepatic disease Primary tumor may be present at study registration provided it is not obstructing the intestinal lumen or is significantly bleeding If present, the primary tumor will be resected at the time of pump placement Must have inoperable liver metastases confirmed by 2-3 hepatobiliary surgeons and the assigned radiologist Liver metastases < 70% of the liver parenchyma Inoperable liver metastases is defined by one of the following: More than 6 metastases in a single lobe with one lesion ≥ 5 cm At least 6 metastases distributed diffusely in both lobes of the liver When a margin-negative resection would require resection of all three hepatic veins, both portal veins, or the retrohepatic vena cava Requires a resection that leaves < 2 hepatic segments (not including the caudate lobe) behind with adequate arterial or portal inflow, venous outflow, and biliary drainage No ascites or hepatic encephalopathy No history of primary CNS tumors PATIENT CHARACTERISTICS: Karnofsky performance status 60-100% WBC ≥ 3,000/mm^3 ANC ≥ 1,500/mm^3 Platelet count ≥ 100,000/mm^3 INR < 1.5 Hemoglobin ≥ 9 g/dL Creatinine ≤ 1.5 mg/dL Total bilirubin ≤ 1.5 mg/dL Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception Physically able to tolerate major partial hepatectomy No active infection No concurrent active malignancies, except potentially resectable primary colorectal tumor No bleeding diathesis or coagulopathy No history of serious systemic disease, including any of the following: Myocardial infarction within the past 6 months Uncontrolled hypertension (i.e., blood pressure > 150/100 mm Hg on medication) Unstable angina New York Heart Association class II-IV congestive heart failure Unstable symptomatic arrhythmia requiring medication Chronic atrial arrhythmia (i.e., atrial fibrillation or paroxysmal supraventricular tachycardia) allowed Peripheral vascular disease ≥ grade 2 No serious or nonhealing active wound, ulcer, or bone fracture No history of seizures not well controlled with standard medical therapy No stroke or transient ischemic attack within the past 6 months No concurrent obstruction of the gastrointestinal or genitourinary tract PRIOR CONCURRENT THERAPY: At least 4 weeks since prior radiotherapy to the pelvis Prior chemotherapy allowed No prior radiotherapy, hepatic thermal ablation, or resection (other than biopsy) to the liver No prior floxuridine No prior hepatic arterial infusion No concurrent chronic aspirin (> 325 mg/day) or nonsteroidal anti-inflammatory medications known to inhibit platelet function No other concurrent investigational agents

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 120 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group 1<br>Patients receive hepatic arterial infusion (HAI) therapy comprising floxuridine and dexamethasone continuously on days 1-14. Patients also receive oxaliplatin IV over 2 hours and irinotecan hydrochloride IV over 30 minutes on days 1 and 15. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. | Drug: dexamethasone<br>* Given by hepatic arterial infusion<br>Drug: floxuridine<br>* Given by hepatic arterial infusion<br>Drug: irinotecan hydrochloride<br>* Given IV<br>Drug: oxaliplatin<br>* Given IV<br>|
| Experimental: Group 2<br>Patients receive HAI therapy as in group 1. Patients also receive irinotecan hydrochloride IV over 30 minutes and leucovorin calcium IV over 30 minutes on days 1 and 15 and fluorouracil IV continuously over 48 hours on days 1, 2, 15, and 16. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. | Drug: dexamethasone<br>* Given by hepatic arterial infusion<br>Drug: floxuridine<br>* Given by hepatic arterial infusion<br>Drug: fluorouracil<br>* Given IV<br>Drug: irinotecan hydrochloride<br>* Given IV<br>Drug: leucovorin calcium<br>* Given IV<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Resectability rate |  | 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Antitumor activity |  | 2 years | 
| Response rate |  | 2 years | 
| Median time to progression |  | 2 years | 
| Survival |  | 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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recurrent colon cancer, stage IV colon cancer, recurrent rectal cancer, stage IV rectal cancer, adenocarcinoma of the colon, adenocarcinoma of the rectum, liver metastases