Identification of Specific Modulation Frequencies in Hepatitis B Carriers With and Without Hepatocellular Carcinoma

Study Overview
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Brief Summary
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The propose of this study is to identification of a group of specific amplitude-modulated frequencies of low intensity electromagnetic fields that is associated with biofeedback upon exposure to in patients with hepatitis B carries with or without hepatocellular carcinoma.

Detailed Description
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Patients will be exposed by different specific amplitude-modulated frequencies of low intensity electromagnetic fields for 30 min. During the exposure, autonomic response with be recorded in order to identify biofeedback response. Differences in group of frequencies is expected in patients with hepatitis B carries with or without hepatocellular carcinoma.

Official Title
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Identification of Specific Modulation Frequencies in Hepatitis B Carriers With and Without Hepatocellular Carcinoma

Conditions
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Hepatitis, Hepatocellular Carcinomas

Intervention / Treatment
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* Device: Low intensity amplitude-moduled electromagnetic fields


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: hepatitis B carriers patients hepatitis B carriers patients with hepatocellular cancer patients Exclusion Criteria: other tumor types other hepatitis types

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: hepatitis<br>hepatitis B carriers patients | Device: Low intensity amplitude-moduled electromagnetic fields<br>* Patients in each arm will be exposed to 30 min of amplitude-moduled low intensity electromagnetic fields only one time.<br>* Other names: OncoBionic P1;|
| Experimental: hepatocellular carcinoma patients<br>hepatites B carriers patients with associated hepatocellular carcinoma | Device: Low intensity amplitude-moduled electromagnetic fields<br>* Patients in each arm will be exposed to 30 min of amplitude-moduled low intensity electromagnetic fields only one time.<br>* Other names: OncoBionic P1;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identification of different group of specific frequencies of modulation in hepatitis B carriers with and without hepatocellular carcinoma associated with biofeedback response | biofeedback response will be monitored | within 10 min of exposure | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Characterization of differences biofeedback response in hepatitis B carriers with and without hepatocellular carcinoma | Representation of autonomous response during the exposure of specific frequencies of modulation | within 10 minutes of exposure | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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biofeedback response