Effects of Sustamine(TM) on Cycling Time Trial Performance

Study Overview
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Brief Summary
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Acute supplementation of Sustamine(TM), a combination of two amino acids, will improve cycling performance and mental acuity in a dose-dependent response.

Official Title
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Effects of Sustamine(TM) on Cycling Time Trial Performance Following Prolonged Cycling

Conditions
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Healthy

Intervention / Treatment
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* Dietary Supplement: Placebo Beverage
* Dietary Supplement: 2.8 g Sustamine Beverage
* Dietary Supplement: 19.6 g Sustamine Beverage


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Competitive cyclist or triathlete Male (VO2max >= 55 ml/kg/min) or Female (VO2max >= 45 ml/kg/min) Healthy Blood pressure below 140/90 Non-smoker Exclusion Criteria: Anti-depressant medications Inconsistent regular medications Consumption performance-enhancing substances Type I or Type II diabetes Renal, hepatic or cardiac disease Current infectious disease

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Placebo<br> | Dietary Supplement: Placebo Beverage<br>* 1400 ml flavored, colored, artificially sweetened, non-caloric beverage divided into 6 servings provided prior to and during the 2.5 hr interval ride.<br>|
| Active Comparator: 2.8 g Sustamine<br> | Dietary Supplement: 2.8 g Sustamine Beverage<br>* 1400 ml flavored, colored, artificially sweetened, beverage containing 2.8 g Sustamine divided into 6 servings provided prior to and during the 2.5 hr interval ride.<br>|
| Active Comparator: 19.6 g Sustamine<br> | Dietary Supplement: 19.6 g Sustamine Beverage<br>* 1400 ml flavored, colored, artificially sweetened, beverage containing 19.6 g Sustamine divided into 6 servings provided prior to and during the 2.5 hr interval ride.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improved Time Trial Performance | Participants will perform an interval ride on a cycling ergometer for 2.5 hr. Intervals will be at 50% or 75% of the participant's VO2max. The time trial will consist of 4 km up a constant grade. | After 2.5 hr interval cycling | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Improved Mental Function | Mental function will be assessed using a computer-based Stroop Test. Measurements will be collected before treatment, before exercise and after exercise. | After time trial | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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glutamine, cycling performance, mental function