Normative Values for the German Version of the Montreal Cognitive Assessment (MoCA)

Study Overview
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Brief Summary
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This observational cohort study in healthy volunteers establishes normative data for the German version of the Montreal Cognitive Assessment (MoCA) and investigates the possible impacts of demographics on the MoCA total score.

Detailed Description
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The Montreal Cognitive Assessment (MoCA) is a short tool to evaluate a multitude of cognitive domains (visuospatial / executive functioning, object naming, memory, attention, language, abstraction, orientation). The original English MoCA consistently showed very high sensitivity and specificity in distinguishing patients with mild cognitive impairment from healthy controls. Therefore it is an excellent tool for early recognition of cognitive disorders. Based on a Canadian sample, the MoCA proposes a cut-off-value of 26/30 points. However, there is increasing evidence of intercultural differences in terms of the best cut-off-score. In addition the original version only slightly corrects for possible influences of education - an adjustment for age- or gender-related effects is missing. Therefore, the aim of our study was to investigate the possible impacts of demographics on the MoCA total score and to provide normative values for a German-speaking population.

Official Title
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Normative Values for the German Version of the Montreal Cognitive Assessment (MoCA)

Conditions
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Cognitive Impairment, Cognitive Decline, Cognition Disorders, Cognitive Symptom, Cognitive Change, Cognitive Deterioration, Cognitive Abnormality, Cognitive Impairment, Mild, Cognition Disorders in Old Age, Dementia, Dementia Alzheimers, Dementia, Alzheimer Type, Dementia, Mild, Dementia of Alzheimer Type

Intervention / Treatment
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* Diagnostic Test: MoCA


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age ≥65 years Education ≥7 years Fluency in the German language Written informed consent Exclusion Criteria: History of cognitive impairment Depression Severe sensory or motor impairment interfering with cognitive testing Serious somatic disease Disease or event affecting the central nervous system Cerebrovascular disease Regular medication with psychoactive drugs except for benzodiazepines Participation in a cognitive study within the last 3 months

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| MoCA cohort<br>The German MoCA is administered once to all study participants. | Diagnostic Test: MoCA<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Montreal Cognitive Assessment (MoCA) - German version | Total score of the MoCA | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mini-Mental State Examination (MMSE) | Total score of the MMSE | Baseline | 
| Geriatric Depression Scale (GDS) | Total score of the GDS | Baseline | 
| Consortium to Establish a Registry for Alzheimer's Disease - Neuropsychological Assessment Battery (CERAD-NAB) | Total score of the CERAD-NAB | Baseline |