Effect of Helicobacter Pylori on the Availability of Vitamin E and C

Study Overview
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Brief Summary
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This study argues that H.pylori infection, by increasing the production of reactive oxygen species, increases the utilization of dietary antioxidants(Vit E and Vit C) that serve in quenching the free radicals, thus decreasing their serum levels and confounding their protective effect against gastric cancer.

Detailed Description
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It has been postulated that dietary antioxidants may reduce cancer risk by modulating red-ox status, by preventing biological oxidation, and by inhibiting the formation of carcinogen. However, supplementation studies and prospective studies have yielded contradictory results. In the case of gastric cancer, H.pylori infection, which is known to be associated with a higher risk of the disease, results in an increased production of ROS & RNS. As a result serum levels of these free radicals increase, exerting a higher demand for dietary antioxidants to neutralize them. The fact that the relation between serum levels of antioxidants and gastric cancer is more consistent than that of dietary intake levels and the disease suggests the possibility of the presence of an intrinsic factor that is altering the true relation between dietary antioxidants and the cancer. This intrinsic factor, this study argues, is the infection with H.pylori. H.pylori infection, by increasing the production of reactive oxygen species, increases the utilization of dietary antioxidants that serve in quenching the free radicals, thus decreasing their serum levels and confounding their protective effect against gastric cancer. The purpose of this pilot study is to investigate the possibility that H.pylori infection alters the bioavailability of the dietary antioxidants: vitamin C, and vitamin E. This project will be done in preparation for an etiologic study of dietary antioxidants and gastric cancer.

Official Title
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Effect of Helicobacter Pylori on the Availability of Vitamin E and C

Conditions
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Heliobacter Pylori Infection

Intervention / Treatment
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* Drug: vitamin C & E supplements


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult , age 18-45 Exclusion Criteria: Smoking Body mass index below 18 or above 25. Previous treatment for H.pylori infection Partial or total gastrectomy History of gastritis Currently taking antioxidants supplementation Training in an athletic team. Drinking more than 3 servings of alcohol/day

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: vitamin C & E supplements|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| plasma vitamin C levels |  |  | 
| plasma vitamin E levels |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| TBARS levels |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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heliobacter pylori infection, reactive oxygen species, antioxidants