Mechanical Ventilation Epidemiology in Argentina.

Study Overview
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Brief Summary
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How is the epidemiology of mechanically ventilated patients in the intensive care units of Argentina?

Detailed Description
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Mechanical ventilation is an indispensable tool in life support and one of the interventions that characterizes intensive care units (ICU). Epidemiological studies have allowed us to improve knowledge and optimize the treatment of patients with acute respiratory failure. In Latin America the epidemiological data of mechanical ventilation is poor. Primary goal of this national, observational, prospective, multicentric epidemiological study: to analyze the survival and describe epidemiological features of patients receiving mechanical ventilation in the Intensive Care Units of Argentina.

Official Title
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Mechanical Ventilation Epidemiology in Argentina. EpVAr Multicenter Study.

Conditions
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Respiration, Artificial, Epidemiology

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ICU patients requiring Mechanical Ventilation at least for 12 hours ICU patients who initiate Mechanical Ventilation in the Operation Room or the Emergency Room ICU patients who initiate Mechanical Ventilation in other institution. Exclusion Criteria: Patients under 18 years old Patients in Pediatric ICU Patients in Coronary ICU Patients without requirements of Mechanical Ventilation Patients who have been discharged from ICU and re-enter during the enrollment period

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival in the ICU | Survival in the ICU will be measured as YES or NO at day 28 after the enrollment. | Up to 28 days after the enrollment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Main reason of Invasive Mechanical Ventilation | Acute respiratory failure in patient with chronic respiratory failure: A)Chronic Obstructive Pulmonary Disease, B) Asthma, C) Other Chronic Obstructive Pulmonary Disease (Idiopathic pulmonary fibrosis, Cystic Fibrosis, Interstitial disease). Acute Respiratory Failure: A) Acute Respiratory Distress Syndrome, B) Postoperative, C) Acute Heart Failure, D) Aspiration, E) Pneumonia, F) Sepsis, G) Trauma, H) Cardiac arrest, I)Others. Coma: A)Metabolic, B)Overdose, Intoxication, C)Stroke, D)Brain trauma. Neuromuscular disease | 1 day | 
| Ventilatory Modes and setting | Volume Control Ventilation, Pressure Control Ventilation, Pressure Support Ventilation, Synchronized Intermittent Mandatory Ventilation, Other (Proportional Assist Ventilation, Neurally Adjusted Ventilation, Airway Pressure Release Ventilation) | Up to 10 days | 
| Tidal Volume | Set tidal volume in mililiters | Up to 10 days | 
| Weaning and mortality | Weaning characteristics and outcome of the patient in terms of mortality. | Up to 28 days | 
| Noninvasive ventilation during weaning and mortality | The use of NIV during weaning and the outcome of the patient in terms of mortality | Up to 28 days | 
| Incidence of delirium | Delirium measured with the CAM- ICU. | Up to 28 days | 
| Incidence of ICU acquired weakness | Periphereal muscle weakness measured with MRC defined as a total value of less than 48 points. | Up to 28 days | 
| Incidence of tracheostomy | Presence of tracheostomy | Up to 28 days | 
| Sedation and analgesia in mechanical ventilation | Implementation of sedation and analgesia during the period of mechanical ventilation. | Up to 28 days | 
| Peak Pressure | Monitored Peak Pressure in centimeters of water | Up to 10 days | 
| Plateau Pressure | Monitored Plateau Pressure in centimeters of water | Up to 10 days | 
| Applied PEEP | Set PEEP in centimeters of water | Up to 10 days | 
| Total PEEP | Monitored total PEEP in centimeters of water | Up to 10 days | 
| Driving Pressure | Monitored Driving Pressure in centimeters of water as the difference between Total PEEP and Plateau Pressure in centimeters of water | Up to 10 days |