Study of Autologous Tumor Infiltrating Lymphocytes (LN-145) In Combo With Durvalumab in Non-Small Cell Lung Cancer

Study Overview
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Brief Summary
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This study is a Phase 2, open-label, multicenter study evaluating adoptive cell therapy (ACT) with autologous TIL therapy (LN-145) in combination with Anti-PD-L1 inhibitor durvalumab.

Detailed Description
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LN-145 is an adoptive cell transfer therapy that utilizes an autologous TIL manufacturing process, as originally developed by the NCI. The cell transfer therapy used in this study involves patients receiving a nonmyeloablative (NMA) lymphocyte depleting preparative regimen, followed by infusion of autologous TIL followed by the administration of a regimen of IL-2.

Official Title
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A Phase 2 Study to Assess the Efficacy and Safety of Autologous Tumor Infiltrating Lymphocytes (LN-145) In Combination With Anti-PD-L1 Inhibitor Durvalumab (MEDI4736) in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Conditions
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Non Small Cell Lung Cancer

Intervention / Treatment
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* Biological: LN-145
* Drug: Durvalumab


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Confirmed diagnosis of Stage III or Stage IV NSCLC and progressed after ≤ 3 lines of prior systemic therapy in the locally advanced or metastatic setting Have at least 1 lesion resectable for TIL generation Measurable disease as defined by RECIST v1.1 Male or female, ≥ 18 years of age Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, and estimated life expectancy of ≥ 3 months Adequate bone marrow function at screening Adequate organ function at screening A washout period from prior anticancer therapy(ies) of a minimum duration is required prior to first study treatment Recovered from all prior anticancer therapy-related AEs to Grade 1 or less (per CTCAE v4.03) prior to enrollment Female patients of childbearing potential and male patients with partners of childbearing potential patient must agree to use contraception while on study and during the timeframes as specified following the last dose of study drug(s) received, or until the first dose of the subsequent anticancer therapy, whichever is longer Evidence of postmenopausal status or negative urine or serum pregnancy test for female premenopausal patients Exclusion Criteria: History of other malignancies, except for the following: adequately treated nonmelanoma skin cancer, curatively treated in-situ cancer of the cervix, curatively-treated thyroid cancer, or other solid tumors curatively treated with no evidence of disease for ≥ 3 years Patients who have received prior cell therapy Patients who have received prior checkpoint inhibitors: such as anti-PD-1, anti-PD-L1 inhibitors, and durvalumab Active or prior documented autoimmune or inflammatory disorders History of primary or acquired immunodeficiency syndrome, history of allogeneic organ transplant that requires therapeutic immunosuppression Received live or attenuated vaccination within 28 days prior to the start of NMA-LD Patients with a history of hypersensitivity to any component of the study drugs Mean QT interval ≥ 470 msec Patients who have a left ventricular ejection fraction (LVEF) of < 45% or who are New York Heart Association (NYHA) Class 2 or higher Serious illnesses or medical conditions, which would pose increased risk for study participation and/or compliance with the protocol Patients who have obstructive or restrictive pulmonary disease and have a documented FEV1 (forced expiratory volume in 1 second) of ≤ 60% Active central nervous system metastases and/or leptomeningeal disease Female patients who are pregnant or breastfeeding Active infection including tuberculosis (TB), hepatitis B, hepatitis C, or HIV Current or prior use of immunosuppressive medication within 28 days before the first dose of study treatment, with the exceptions of intranasal and inhaled corticosteroids or systemic corticosteroids at physiological doses, which are not to exceed 10 mg/day of prednisone, or an equivalent corticosteroid

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: LN-145 in combination with durvalumab<br>After nonmyeloablative (NMA) lymphodepletion, patients are infused with their autologous TIL (LN-145) followed by IL-2 administration. | Biological: LN-145<br>* adoptive cell therapy (ACT) with autologous TIL therapy<br>* Other names: TIL, autologous tumor infiltrating lymphocytes;Drug: Durvalumab<br>* PD-L1 antagonist monoclonal antibody<br>* Other names: MEDI4736;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Objective Response Rate | To evaluate efficacy using the objective response rate (ORR) | A maximum of 24 months | 
| ≥ Grade 3 Treatment-Emergent Adverse Event | To evaluate the safety as measured by any ≥ Grade 3 treatment-emergent adverse event (TEAE) rate | A maximum of 24 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of Response | To further evaluate efficacy such as the duration of response (DOR) | A maximum of 24 months | 
| Progression Free Survival | To further evaluate efficacy such as progression free survival (PFS) | A maximum of 24 months | 
| Overall Survival | To further evaluate efficacy such as overall survival (OS) | A minimum of 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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TIL, IL-2, LN-145, Cell Therapy, Autologous Adoptive Cell Transfer, Cellular Immuno-therapy, Durvalumab