Endometriosis and Obstetric Outcomes

Study Overview
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Brief Summary
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The purpose of this study is to assess if endometriosis can be considered a risk factor for adverse obstetric and delivery outcomes

Detailed Description
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This is a retrospective, observational, case-control study. Pregnancy, delivery and neonatal outcomes will be analyzed in two groups of patients (case and control group): women with diagnosis of endometriosis histologically confirmed and women without endometriosis. Women with endometriosis will be matched to controls by age. A database with general medical and gynecological history, pregnancy course, delivery mode and newborn conditions will be analyzed.

Official Title
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Endometriosis and Risk Factors in Pregnancy, Labor and Delivery

Conditions
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Endometriosis, Obstetric Complication

Intervention / Treatment
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* Other: Retrospective analysis of obstetrics outcomes


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Pregnant women who delivered at Azienda Ospedaliero Universitaria Policlinico di Modena from 2000 to 2020 Histologic diagnosis of endometriosis before pregnancy for case group Age matched healthy patients for control group Exclusion Criteria: Clinical records not available
Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with previous histologic diagnosis of endometriosis<br> | Other: Retrospective analysis of obstetrics outcomes<br>* Retrospective analysis of clinical records including general medical and gynecological history, pregnancy course, delivery mode and newborn conditions.<br>|
| Patient without endometriosis<br> | Other: Retrospective analysis of obstetrics outcomes<br>* Retrospective analysis of clinical records including general medical and gynecological history, pregnancy course, delivery mode and newborn conditions.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Preterm delivery | Incidence of delivery before 37 weeks of pregnancy | Time of delivery | 
| Gestational diabetes | fasting blood glucose >17 mmol/L | after 18 weeks' pregnancy | 
| Gestational hypertension | blood pressure persistently > 140/90 mm Hg | after 20 weeks' gestation | 
| Assisted reproduction technologies | Patients who referred to assisted reproduction technologies | before pregnancy | 
| Cesarean Section | Robson Classifications | Time of delivery | 
| Postpartum hemorrhage | Greater than 500 mL estimated blood loss in a vaginal delivery or greater than 1000 mL estimated blood loss at the time of cesarean delivery | Time of delivery | 
| Birth-weight | small for gestational age (birth weight below the 10th percentile) or large for gestational age (birth weight over the 90th percentile) | Time of delivery | 
| Apgar scores | Apgar scores | Time of delivery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Endometriosis, Obstetric outcome, Delivery outcome, Neonatal outcome