Evaluation of Acetabular Perfusion After Ganz Osteotomy by Positron Emission Tomography

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to examine the blood flow in acetabulum after periacetabular osteotomy by Positron Emission Tomography (PET).

Detailed Description
-----------------
As a consequence of periacetabular osteotomy the blood flow in acetabulum is decreased. After periacetabular osteotomy has been performed there is fine contact between the osteotomised acetabulum and the rest of the pelvis and the potential for healing is good. However, it has not been investigated how much the blood flow in acetabulum is changed after surgery. The blood flow is considered to be vital for how the pelvis heals after surgery. Most likely, the blood flow is important in relation to which degree osteoarthritis can be prevented after periacetabular osteotomy. It is possible to estimate the blood flow by Positron Emission Tomography of the dysplastic hip joint pre- and postoperatively. In this study the blood flow and fluoride uptake is quantified by Positron emission tomography based on measurements of O-15 water and F-18 fluoride.

Official Title
-----------------
Evaluation of Acetabular Perfusion After Ganz Osteotomy by Positron Emission Tomography

Conditions
-----------------
Osteoarthritis

Intervention / Treatment
-----------------
* Procedure: Periacetabular osteotomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with radiologically diagnosed hip dysplasia (CE-angle < 25°). Patients with osteoarthritis graded 0, 1 or 2 defined according to Tönnis' classification. Patients with pain from hip Age > 18 years. Minimum 110° flexion in hip joint and closed growth zones in the pelvic. Informed consent. Exclusion Criteria: Patients with neurological diseases Patients with calvé-Legg-Perthes syndrome. Patients where an femoral intertrochanteric osteotomy is necessary. Patients with medical sequelae after earlier hip surgery. Females who are pregnant. Patients with metal implants.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: periacetabular osteotomy<br> | Procedure: Periacetabular osteotomy<br>* osteotomy of the pelvis to increase acetabular coverage<br>* Other names: PAO;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| changes in blood flow |  | within the first three weeks after operation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fluoride uptake |  | within the first three weeks after operation | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
PET, Periacetabular osteotomy