Topotecan for Irinotecan-Refractory SCLC

Study Overview
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Brief Summary
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Although the efficacy of topotecan as second-line chemotherapy for SCLC has been consistently demonstrated in phase II/III clinical trials, the choice of irinotecan as first-line therapy prevented use of the evidence-based option. This pilot study will be conducted to determine the activity and safety of topotecan in SCLC patients refractory to first-line therapy with irinotecan and platinum.

Detailed Description
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Current commonly used second-line approaches for SCLC include re-induction with first-line therapy for chemosensitive disease, or single-agent topotecan. Although the efficacy of topotecan as second-line chemotherapy for SCLC has been consistently demonstrated in a number of clinical studies, the choice of irinotecan as first-line therapy prevented use of the evidence-based option such as topotecan. Topotecan and irinotecan are cytotoxic agents that inhibit same intracellular pathway, namely topoisomerase I, which is an enzyme involved in DNA replication and RNA transcription. Although their mechanism of action is similar, the preclinical and clinical data of these two drugs have some notable differences. Topotecan and irinotecan have different spectra of antitumor activity in various models of human cancer. Clinical data support that these agents may have different spectra of activity. The differences in antitumor activities may also reflect different mechanisms of resistance. Furthermore, topotecan and irinotecan have different limiting toxicities (myelosuppression and diarrhea, respectively).

Official Title
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Salvage Treatment With Topotecan in Patients With Irinotecan-Refractory Small Cell Lung Cancer

Conditions
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Lung Cancer, Refractory to Chemotherapy

Intervention / Treatment
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* Drug: topotecan


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: histologically or cytologically proven SCLC refractory to prior irinotecan-based chemotherapy Eastern Cooperative Oncology Group (ECOG) performance status ≤2 age between 18 and 75 years no active brain or leptomeningeal metastases adequate hematologic, hepatic and renal functions at least one measurable lesion(s) Exclusion Criteria: pregnant or lactating women patients with active infection extensive radiotherapy within the previous 4 weeks previous other malignancies with the exception of adequately treated non-melanoma skin cancer or in situ cervical cancer any severe comorbid illness a known history of anaphylaxis of any origin history of severe adverse events to the drug used in this study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: topotecan|nan|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Response rate |  |  | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety |  |  | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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small-cell lung cancer, refractory, topotecan