linjc16/ctgov huggingface dataset:
Synchronous Video (Telemedicine) Consulation in the Prehospital Setting

Study Overview
=================
Brief Summary
-----------------
The study team aims to test connectivity metrics and follow patient outcomes using a new, innovative synchronous video technology in the prehospital setting in three distinct areas: - 911 Calls - Pediatric Critical Care Transport Currently, paramedics and pediatric transport teams seek advice from physicians using a telephone. This project replaces the phone with video consultation where the physicians can directly interact with patients, paramedics and transport teams when care advice is needed.

Official Title
-----------------
Synchronous Video (Telemedicine) Consulation in the Prehospital Setting

Conditions
-----------------
Emergencies, Prehospital, Telemedicine, Telehealth

Intervention / Treatment
-----------------
* Device: Video Consultation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Cardiac Arrest Hemodynamically unstable trauma patients requiring resuscitation and airway management Trauma patients with altered mentation requiring airway management Acute stroke patients Medical patients that refuse transport for medical evaluation Pediatric Intensive Care Telemedicine Program Complex clinical situations where paramedic teams need immediate management guidance Critically ill pediatric patients requiring evaluation/stabilization for interfacility transport Pediatric patients requiring intervention for respiratory failure Pediatric patients with ongoing seizures and/or neurological abnormalities Hemodynamically unstable patients Complex clinical situations requiring medical control guidance Exclusion Criteria: • All other patients not list above
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Synchronous Video Consultation<br>Testing the feasibility of a synchronous video consultation in the field prior to emergency department arrival. | Device: Video Consultation<br>* Video consultation with emergency medicine physicians for patients that are critically ill prior to arrival in the ED<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Video Consultations Completed | Total number of video consultations completed | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality | Total number of subject deaths | 1 year | 
| Hospital Length of Stay | Total number of hours subjects were admitted to the hospital | 1 year | 
| Emergency Room Length of Stay | Total number of hours subjects were admitted to the emergency room | 1 year |
Educational Follow-up in COPD Patients After Pulmonary Rehabilitation.

Study Overview
=================
Brief Summary
-----------------
After pulmonary rehabilitation, the challenge is to maintain the benefits reached during the program and increase physical activity. As exercise training, education is the corner stone of pulmonary rehabilitation. Education allows to support behavioral changes in daily life. Recommendations about modalities for maintaining physical activity are still clear, however for educational follow up recommendations need to be clarified. After a pulmonary rehabilitation program, there is no defined plan for educational follow up nor location to perform education session. The aim of this study is to evaluate the proportion of patients who succeed to establish and maintain the objectives they defined during the pulmonary rehabilitation program, one year after this program.

Official Title
-----------------
Educational Follow-up in COPD Patients After Pulmonary Rehabilitation: a Cohort Study

Conditions
-----------------
Chronic Obstructive Pulmonary Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: COPD patients COPD patients admitted for pulmonary rehabilitation program in pulmonary rehabilitation unit of CH des Pays de Morlaix or CHU Brest Exclusion Criteria: inability to answer to the questionnaire refusal to participate. inability to perform the pulmonary rehabilitation program.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Realization of the objective(s) defined by the patient during a common educational assessment (educational diagnosis) at the end end of the pulmonary rehabilitation program | Determination of the objective(s) defined by the patient during a common educational assessment (educational diagnosis) at the end of the pulmonary rehabilitation program and evaluation of the realization of this (these) objective(s) after one year (yes or no) | one year |
Emerging Invasive Fungal Infections in Critically Ill Patients

Study Overview
=================
Brief Summary
-----------------
Rationale: Beside Candida and Aspergillus, emerging invasive fungal infections (EIFIs) are increasing in intensive care setting and are associated with high morbidity and mortality. However, data are scarce, particularly in ICU settings and for EIFIs other than mucormycosis. Objectives: to describe epidemiological trends and clinical features of EIFIs in intensive care units (ICU) and to assess their outcome. Methods: All records of adult patients diagnosed with an EIFI in a medical ICU between 2006 and 2019 were analyzed retrospectively. In-ICU mortality was assessed, then factors associated with mortality were identified. Survival at day-90 was calculated by the Kaplan-Meier method.

Official Title
-----------------
Emerging Invasive Fungal Infections in Critically Ill Patients: Epidemiological Trends, Clinical Features and Outcomes

Conditions
-----------------
Fungal Infection, ICU Acquired Weakness

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: - Adults (≥ 18 years old) with at least 1 positive culture for molds other than candida and aspergillosis Exclusion criteria: - Age < 18, pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 99 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| mortality | mortality | at ICU admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mucormycosis | Mucormycosis | at ICU admission | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Emergind invasive fungal infection, mucormycosis, ICU
Postoperative Surgical Site Infection afterENT Bone Flap Surgery

Study Overview
=================
Brief Summary
-----------------
In 2017, the French Society in anesthesia and reanimation published new recommendations on intraoperative antibiotic prophylaxis. Now, no more than 48 hours of antibiotic prophylaxis applies to any otolaryngology surgery, regardless of patient's medical history or type of flap used to rebuild. This has resulted in an alignment of our local protocol in Croix-Rousse hospital. However, after few years, our local impressions are that bone flap surgeries are very likely to provide surgical site infections (osteo-articular or non-osteo-articular infections). The prejudice of these postoperative site infections is significant, with serious consequences,. of both functional and aesthetic sides. We wanted to objectify this impression by retrospectively analyzing the data relating to patients operated on for bone flapsurgeries. Knowing the operation site infection rate after surgery for otolaryngology bone flap surgery will allow us to objectively understand the infectious risk of these surgeries, in particular the risk of osteoarticular infection. Identifying operation site infection factors will allow us to better target and prevent them. The goal is to find out if the antibiotic prophylaxis currently recommended is sufficient and effective for this type of surgery.

Official Title
-----------------
Evaluation of the Occurrence of Postoperative Surgical Site Infection in Otolaryngology Flap Surgery With Bone Graft, a Retrospective Analytic Study Between 2012 and 2019

Conditions
-----------------
Post-operative Surgery, Bone Flap Surgery, Otolaryngology, Rate of Infections, Operating Site

Intervention / Treatment
-----------------
* Procedure: Postoperative infections rate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient operated for bone flap in Croix-Rousse hospital, in otorhinolaryngology department, since september 2012 and until January 2019 Exclusion Criteria: patient's opposition to participate in the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Infected patients<br>patients with bone flap surgeries | Procedure: Postoperative infections rate<br>* Assess the postoperative infection rate after otolaryngology bone flap surgery.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative infections rate after otolaryngology bone flap surgery | Assess the postoperative infection rate after bone flap otolaryngology surgery | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bone flap surgery, postoperative surgical infection
Angiotensin-Converting Enzyme Gene Polymorphism and the Risk of Chronic Allograft Nephropathy

Study Overview
=================
Brief Summary
-----------------
This study is intended to help doctors learn about the relationships between specific genetic makeup (gene markers) and the development of chronic rejection. This study is being done to see if there is a relationship between genetic patterns and the development of Chronic Allograft Nephropathy (CAN). Medical scientists also hope to learn more about how genetic differences between people determine their response to a drug or a disease by storing a small blood sample in a special bank. This sample may be tested at some point in the future in an attempt to better understand the factors that may influence rejection, transplantation outcomes and transplant success rates.

Conditions
-----------------
Kidney Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All subjects must be recipients of a renal allograft. Study subjects must have evidence of biopsy-proven Chronic Allograft Nephropathy (CAN). Control subjects must not have evidence of CAN.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Chronic Allograft Nephropathy (CAN), Transplantation immunology, Genetics, Graft Rejection
Home Use of Mechanical Insufflation/Exsufflation Devices in Neuromuscular Diseases

Study Overview
=================
Brief Summary
-----------------
With this cross-sectional study of adult subjects with neuromuscular disease in the French-speaking part of Switzerland, we aim to explore MI-E adherence using self-report questionnaires and device data in order to identify the factors that influence the pattern of MI-E use and satisfaction with the treatment. Determining potential barriers to regular long-term home use of MI-E could help in identifying the patients who would benefit most from this therapy.

Official Title
-----------------
Predictors of Home Use of Mechanical Insufflation/Exsufflation Devices in Neuromuscular Patients: a Cross-sectional Study

Conditions
-----------------
Neuromuscular Diseases

Intervention / Treatment
-----------------
* Device: Mechanical insufflation/exsufflation device (MI-E)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age over 18 years Diagnosis of neuromuscular disease Active prescription of MI-E for more than 3 months Exclusion Criteria: -Invasive airway

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| subjects with neuromuscular disease<br>Adult subjects with neuromuscular disease, with an active prescription of MI-E for more than 3 months | Device: Mechanical insufflation/exsufflation device (MI-E)<br>* download of device (MI-E) data and self-reported satisfaction with the device<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adherence to MI-E (reported) | based on self-reported use | 12 months, or since treatment initiation (> 3 months) | 
| Adherence to MI-E (objective) | based on data downloads | 12 months, or since treatment initiation (> 3 months) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Satisfaction with the device | Self-report questionnaire | 12 months, or since treatment initiation (> 3 months) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Mechanical insufflation-exsufflation, Cough assistance
Excessive Warfarin Anticoagulation - Causes and Consequences

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to investigate the clinical significance of high INR (International Normalized Ratio) values (>9) in VKA (vitamin K antagonist) treated patients with atrial fibrillation. The clinical characteristics of these patients will be studied as well as the clinical presentation. Factors influencing on high INR values will be recorded and the aim is to seek out patients who have elevated risk of bleeding complications.

Detailed Description
-----------------
This is a retrospective study setting. Source data will be collected by reviewing medical records and through computer searches. The basic study population will be identified from laboratory INR test results taken between 2003-2015. Identifying patients with INR values over 9 will be selected for further analysis, concerning the clinical presentation, patient characteristics, 90 day survival and adverse event rates. The focus is in identifying patient characteristics and factors influencing the risk of high INR value. Also we will analyse the effects of medically reversing the high INR values on stroke and other adverse event rates. The results will be collected manually using an electronic case report form, and analysed statistically using SPSS/SAS statistics tool.

Official Title
-----------------
Excessive Warfarin Anticoagulation - Causes and Consequences

Conditions
-----------------
Anticoagulation

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: VKA treatment, age > 18, INR >9, Exclusion Criteria: age < 18
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| All cause mortality |  | 90 days |
Effects of Grapefruit or Grapefruit Juice on Anthropometry, Dietary Intakes, Appetite, and Metabolic Profile in Overweight and Obese Young and Middle-Aged Adults

Study Overview
=================
Brief Summary
-----------------
This trial examines the effects of grapefruit or grapefruit juice on anthropometry, dietary intakes, appetite, and metabolic profile in overweight and obese young and middle-aged adults.

Official Title
-----------------
Effects of Grapefruit or Grapefruit Juice on Anthropometry, Dietary Intakes, Appetite, and Metabolic Profile in Overweight and Obese Young and Middle-Aged Adults

Conditions
-----------------
Obesity

Intervention / Treatment
-----------------
* Behavioral: diet (grapefruit or grapefruit juice)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: BMI 30-39.9 Exclusion Criteria: Pregnant or lactating On medications that are interfered with by consuming grapefruit juice

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: G<br>grapefruit | Behavioral: diet (grapefruit or grapefruit juice)<br>* weight loss diet<br>|
| Active Comparator: J<br>Juice | Behavioral: diet (grapefruit or grapefruit juice)<br>* weight loss diet<br>|
| Placebo Comparator: W<br>placebo | Behavioral: diet (grapefruit or grapefruit juice)<br>* weight loss diet<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| weight loss |  | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| metabolic syndrome |  | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
obesity, diet, weight loss, metabolic syndrome
Outcomes of Neoadjuvant Therapy for Rectal Cancer in a Tertiary Asian Institute

Study Overview
=================
Brief Summary
-----------------
This is a retrospective cohort study that aims to evaluate the correlation of magnetic resonance tumour regression grade (mrTRG) and pathological TRG (pTRG) of locally advanced rectal cancer after neoadjuvant long course chemoradiotherapy as well as the prognostic value of mrTRG on survival.

Official Title
-----------------
Outcomes of Neoadjuvant Therapy for Rectal Cancer in a Tertiary Asian

Conditions
-----------------
Rectal Cancer, Oncology

Intervention / Treatment
-----------------
* Radiation: neoadjuvant long course chemoradiotherapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Rectal cancer At least 1 high risk feature on MRI Undergo long course neoadjuvant chemoradiotherapy (LCCRT) Exclusion Criteria: metastatic disease Patients who undergo short course radiotherapy Patients without a repeat MRI after completion of LCCRT
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Radiation: neoadjuvant long course chemoradiotherapy|neoadjuvant long course chemoradiotherapy consist of radiosensitizing 5FU or capecitabine and 50.4 Gy in 28 fractions over 5 weeks|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between mrTRG and pTRG |  | Between 1 Jan 2011 to 31 Dec 2016 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prognostic value of mrTRG on survival outcomes of rectal cancer patients |  | Between 1 Jan 2011 to 31 Dec 2016 |
Use of Chewing Gum to Facilitate Appetite Control and Weight Loss

Study Overview
=================
Brief Summary
-----------------
This purpose of this study was to test the use of chewing gum as an adjunct to lifestyle modification to facilitate appetite control and weight loss in overweight and obese individuals.

Official Title
-----------------
Use of Chewing Gum to Facilitate Appetite Control and Weight Loss in Overweight Individuals Treated by Lifestyle Modification

Conditions
-----------------
Overweight, Obesity

Intervention / Treatment
-----------------
* Behavioral: Lifestyle modification
* Behavioral: Lifestyle modification plus gum


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 21-75 years of age Body Mass Index of 25-45 inclusive Exclusion Criteria: major medical psychiatric conditions medications know to effect weight full or partial dentures 18 or fewer teeth regular gum chewing (≥ 2 pieces/day) use of any tobacco product sensitivity to the following ingredients (mint, magnolia bark, eggs, or English Muffins) history of PKU sensitivity or allergy to aspartame current/history of alcohol abuse or addiction (within 5 year) recreational drug use recent significant weight change (+/- 5% in previous 6 months) currently pregnant or nursing and willingness not to get pregnant during course of study participation in any other research studies proximity to clinic (within one hour) access to reliable transportation

Ages Eligible for Study
-----------------
Minimum Age: 21 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 1<br>Overweight/obese individuals being treated with lifestyle modification to facilitate weight loss. | Behavioral: Lifestyle modification<br>* 16 weekly followed by 8 monthly group behavioral weight loss sessions.<br>* Other names: Behavioral weight loss;|
| Experimental: 2<br>Lifestyle modification plus use of chewing gum to facilitate weight loss in overweight/obese persons. | Behavioral: Lifestyle modification plus gum<br>* 16 weekly followed by 8 monthly group behavioral weight loss sessions. Subjects were also given gum along with instructions for times and occasions to chew with the aim of facilitating weight loss and appetite control.<br>* Other names: Behavioral weight loss;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Weight loss |  | Week 16 and 52 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Appetite control |  | Weeks 4, 8, 12, 16 and 52 |