linjc16/ctgov huggingface dataset:
Treatment of Ocular Demodicosis by Cleansing the Eyelid Margins Combined With Tea Tree Oil Ointment

Study Overview
=================
Brief Summary
-----------------
To investigate whether the cleaning of eyelid margins increases the effectiveness of traditional tea tree oil eyelid margins in treating mites. The investigators randomly divided 60 participants into two groups: Group A was treated with traditional tea tree oil eyelid margin, Group B was treated with traditional tea tree oil eyelid margin + eyelid cleansing, and participants were rechecked after 3 months of regular medication.

Official Title
-----------------
Treatment of Ocular Demodicosis by Cleansing the Eyelid Margins Combined With Tea Tree Oil Ointment

Conditions
-----------------
Mite-Borne

Intervention / Treatment
-----------------
* Other: cleansing the eyelid margins


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Clinical diagnosisof ocular surface mite parasitism Exclusion Criteria: any acute keratoconjunctivitis;c dacryocystitis

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Treatment of ocular demodicosis<br> | Other: cleansing the eyelid margins<br>* using eyelid cleaning wipes to cleansing the eyelid margins<br>* Other names: tea tree oil;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The severity of dry eyes | OSDI dry eye questionnaire | 3 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
eyelid margins, ocular demodicosis
Brief Assessment of Impaired Cognition

Study Overview
=================
Brief Summary
-----------------
The aim is to develop and validate a new brief and accurate case-finding instrument for dementia and cognitive impairment - BASIC

Detailed Description
-----------------
The case-finding instrument consists of four components: a. patient-directed questions, b. supermarket fluency, c. category-cued Memory Test, d. informant-directed questions. The data collection was carried out at five outpatient memory clinics in Denmark

Official Title
-----------------
Brief Assessment of Impaired Cognition

Conditions
-----------------
Dementia

Intervention / Treatment
-----------------
* Diagnostic Test: BASIC


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: fluent in Danish Exclusion Criteria: impaired eyesight or hearing

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cases referred from GP<br>BASIC (Brief Assessment of Impaired Cognition) MMSE (Mini Mental State Examination) Extensive diagnostic work-up including clinical interview, neurological and physical examination, laboratory screening tests, structural neuroimaging | Diagnostic Test: BASIC<br>* Validation<br>|
| Healthy controls<br>Test performed: BASIC MMSE GDS-15 (Geriatric Depression Scale) | Diagnostic Test: BASIC<br>* Validation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Brief Assessment of Impaired Cognition (BASIC) | Dementia and cognitive impairment cutoff 20/21 | through study completion, an average of 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
validation, casefinding tool
Optimized Supervised Education Program for Peripheral Arterial Disease

Study Overview
=================
Brief Summary
-----------------
Peripheral arterial disease (PAD) is a frequent and serious chronic disease witch is undertreated. The recommended management of PAD include pharmacological approach and lifestyle modifications. Patient education help to reach this outcome. Our study propose to compare patient education management with physical activity coaching to usual care.

Official Title
-----------------
Optimized Supervised Education Program for Peripheral Arterial Disease: Ambulatory Management With Patient Education

Conditions
-----------------
Peripheral Arterial Disease

Intervention / Treatment
-----------------
* Other: Patient education


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients aged 18 to 75 years With peripheral arterial disease Who accept to follow a patient education program Exclusion Criteria: Permanent limb ischemia Revascularisation programmed in the 6 next months Other severe prognostic disease Difficulties to obtain patient consent because of language or understanding

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: patient education<br>individual and group meetings with explanations about the disease, lifestyle counseling ; coaching by phone at 1 and 4 months; medical consultation at 3 months; physical exercise with coaching | Other: Patient education<br> <br> |
| No Intervention: Usual care<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 6 minutes walking test |  | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Peripheral arterial disease, Patient education, Physical activity coaching, Lifestyle modifications, Walking capacity, 6 minutes walking test
Early Mobilization: Evaluation of Feasibility and Security in Pediatric Intensive Care Unit

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to evaluate the feasibility and the security of early mobilization of infants in pediatric intensive care.

Conditions
-----------------
Cardio-Respiratory Distress

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: cardiorespiratory stability between 24 and 48h post admission Exclusion Criteria: Thorax open ECLS High frequency oscillatory ventilation

Ages Eligible for Study
-----------------
Maximum Age: 2 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Respiratory parameters assessed by monitoring | cardiac frequency, respiratory frequency, blood pressure | up to 1 hour | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| EDIN scale (tool for assessing prolonged pain in preterm and newborns) |  | 5 minutes before mobilization | 
| EDIN scale (tool for assessing prolonged pain in preterm and newborns) |  | up to 1 hour | 
| COMFORT-BEHAVIOR scale (to measure the amount of stress of ventilated infants in a pediatric intensive care unit) |  | 5 minutes before mobilization | 
| COMFORT-BEHAVIOR scale (to measure the amount of stress of ventilated infants in a pediatric intensive care unit) |  | up to 1 hour |
Epidemiologic Analysis of Change in Eyelash Characteristics With Age in Healthy Women

Study Overview
=================
Brief Summary
-----------------
This study will asses epidemiologic changes in eyelash characteristics with increasing age.

Conditions
-----------------
Health

Intervention / Treatment
-----------------
* Other: No treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Willing to have photographs taken of the face/eye regions Exclusion Criteria: No visible eyelashes Permanent eyeliner or eyelash implants Semi-permanent eyelash tint, dye, or extensions within the last 3 months Use of prescription eyelash growth products in the last 6 months

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Healthy Females<br>Healthy Females | Other: No treatment<br>* No treatment will be provided<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Eyelash Length as Measured by Digital Image Analysis (DIA) | Photographs were taken of the eyelashes. Length was measured in millimeters. Data from both eyes were averaged for each participant for analysis. | Baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Eyelash Thickness as Measured by Digital Image Analysis (DIA) | Photographs were taken of the eyelashes. Eyelash thickness/fullness was assessed across both eyes as an average of the 3 preset areas measured in millimeters squared (mm^2). | Baseline | 
| Eyelash Darkness as Measured by Digital Image Analysis (DIA) | Photographs were taken of the Eyelashes. Eyelash darkness (intensity) was measured within the spline (a narrow area approximately 5 pixels wide that bisects the area of interest). Eyelash darkness was measured in both eyes and averaged for analysis using a scale where 0=black and 255=white. | Baseline |
The Effect of Modified Valsalva Maneuver on Filling Degree of Internal Jugular Vein

Study Overview
=================
Brief Summary
-----------------
To explore the effect of modified valsalva maneuver on the filling degree of right internal jugular vein. Method: The anteroposterior diameter and left-right diameter of right internal jugular vein in thirty adult gynecology patients were recorded during normal respiration and modified valsalva maneuver respectively. Investigators hypothesis that modified valsalva maneuver would enchance the filling degree of right internal jugular vein.

Official Title
-----------------
The Effect of Modified Valsalva Maneuver on Filling Degree of Internal Jugular Vein

Conditions
-----------------
the Filling of Jugular Vein Before Anesthesia With and Without Valsalva Maneuver

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: - female patients age 18-60 years Exclusion Criteria: heart or lung disease mental illness communication barriers.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the change of the diameter of right internal jugular vein after modified valsalva maneuver |  | up to 4 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
modified valsalva maneuver, internal jugular vein
A Study to Evaluate P-Glucose, Safety and Tolerability After Oral Single Dosing of AZD6370 in Type 2 Diabetic Patients

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to assess the effect of AZD6370 on blood sugar and to study safety and tolerability in patients with type 2 diabetes.

Official Title
-----------------
A Dose-Ranging Study to Evaluate Fasting and Postprandial P-Glucose, Safety and Tolerability After Oral Single, B.I.D and Q.I.D Dosing of AZD6370 in Patients With Diabetes Mellitus: a Randomized, Single-Blind, Placebo-Controlled, Phase I Study

Conditions
-----------------
Type 2 Diabetes

Intervention / Treatment
-----------------
* Drug: AZD6370
* Drug: AZD6370
* Drug: Placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Treated with diet or metformin. Stable glycemic control indicated by no changed treatment within 3 months Diabetes Mellitus diagnosis <5 years Exclusion Criteria: Clinically significant illness or clinically relevant trauma, as judged by the investigator, within two weeks before the first administration of the investigational product Clinically significant abnormalities in clinical chemistry, hematology, or urinalysis results

Ages Eligible for Study
-----------------
Minimum Age: 30 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Part A, arm 1<br>1) 8 pats: AZD6370 increasing oral single doses a+b+c+placebo together with food | Drug: AZD6370<br>* Oral single doses a+b+c, o.d., suspension<br>|
| Experimental: Part A, arm 2<br>1) 8 pats: AZD6370 increasing oral single doses a+b+c+placebo without food | Drug: AZD6370<br>* Oral single doses a+b+c, o.d., suspension<br>|
| Experimental: Part B, arm1, 2, and 3<br>AZD6370 dose x mg o.d. dose x/2 mg b.i.d. dose x/4 mg q.i.d. | Drug: AZD6370<br>* Oral single dose, o.d., b.i.d. and q.i.d., suspension<br>|
| Experimental: Part B, arm 4<br>4) Placebo | Drug: Placebo<br>* Placebo<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pharmacodynamic variables |  | Blood samples taken repeatedly during 24 hours on study day sessions | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Safety variables |  | Blood samples taken repeatedly during 24 hours on study day sessions | 
| Pharmacokinetic variables |  | Blood samples taken repeatedly during 24 hours on study day sessions | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Type 2 diabetes
Heliox for Neonate With Acute Respiratory Distress Syndrome (ARDS)

Study Overview
=================
Brief Summary
-----------------
Acute respiratory distress syndrome (ARDS) in neonates has been defined, the role of heliox is not clear.This study aimed to determine whether ARDS neonate would benefit from heliox when oxygenation deteriorated on mechanical ventilation and to identify any potential risk factors related to mortality.

Detailed Description
-----------------
Acute respiratory distress syndrome (ARDS) can result in severe hypoxemia refractory to mechanical ventilation, mechanical ventilation including high frequency oscillation ventilation is the main method. But it is partial unuseful.

Official Title
-----------------
Heliox for Neonate With Acute Respiratory Distress Syndrome (ARDS): A Randomized Controlled Trial

Conditions
-----------------
ARDS

Intervention / Treatment
-----------------
* Drug: heliox combined with MV
* Drug: MV


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: infant less than 28 days diagnosis of ARDS informed parental consent has been obtained Exclusion Criteria: major congenital malformations or complex congenital heart disease transferred out of the neonatal intensive care unit without treatment

Ages Eligible for Study
-----------------
Minimum Age: 30 Minutes
Maximum Age: 28 Days

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: heliox combined with mechanical ventilation (MV)<br>heliox combined with mechanical ventilation (MV) is given to infant with ARDS | Drug: heliox combined with MV<br>* heliox combined with MV is given to infant with ARDS<br>|
| Active Comparator: mechanical ventilation<br>mechanical ventilation (MV) is given to infant with ARDS | Drug: MV<br>* MV is given to infant with ARDS<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| death | death | within 100 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bayley Scales of Infant Development | the survival is assessed by Bayley Scales of Infant Development | at 2 months old and 2 years old |
Electronic Medical Record Reminders and Panel Management to Improve Primary Care of Elderly Patients

Study Overview
=================
Brief Summary
-----------------
The investigators conducted a controlled trial to assess the effectiveness of electronic medical record (EMR) reminders, with or without a panel manager, on completion of health care proxy, osteoporosis screening, and influenza and pneumococcal vaccinations for patients age 65 or older. The investigators hypothesized that EMR reminders would improve adherence to practice guidelines and that benefits would be enhanced with the support of a panel manager.

Official Title
-----------------
Electronic Medical Record Reminders and Panel Management to Improve Primary Care of Elderly Patients

Conditions
-----------------
EMR Reminders to Improve Rates of Recommended Care

Intervention / Treatment
-----------------
* Other: EMR Reminder
* Other: EMR Reminder + Panel management


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All practicing faculty primary care physicians at Beth Israel Deaconess Medical Center General Medicine & primary care ambulatory clinic Exclusion Criteria:
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: EMR reminder<br>EMR reminder | Other: EMR Reminder<br>* EMR reminders displayed<br>|
| Experimental: EMR reminder + Panel management<br>EMR reminder + Panel manager | Other: EMR Reminder + Panel management<br>* EMR Reminder + Panel management<br>|
| No Intervention: Control<br>Control | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| a designated health care proxy | A designated health care proxy was defined as a verified proxy documented in the EMR's health care proxy field | 12 months after intervention made available | 
| initial bone density scan | The initial bone density scan measure was defined as having either bone density scan ordered or a bone density scan completed | 12 months after intervention made available | 
| administration of annual influenza vaccine | Administration of influenza vaccine was defined as vaccine documented as given at any location | 12 months after intervention started | 
| administration of pneumococcal vaccine | Administration of pneumococcal vaccine was defined as vaccine documented as given at any location. | 12 months after the start of the intervention | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Electronic medical record reminders, Panel management
Prevalence of Chronic Inebriates to the Emergency Department and Suitability for Sobering House Services

Study Overview
=================
Brief Summary
-----------------
This study is intended to evaluate the prevalence of chronically inebriated patients in the Emergeny Department (ED). Patients will be identified prospectively by screening all patients (24/7) presenting to the ED for one month. A running tally of all patients in the ED will be kept. Of these patients, any patient that is noted to have alcohol intoxication will be identified. The chart of that patient will be reviewed for details about the patient's alcohol use and for the patient's suitability for a sobering house, which is a place where intoxicated patients can go to await sobriety. The chart will also be reviewed for the number of previous visits for alcohol use to our hospital ever and in the last year.

Detailed Description
-----------------
For this cross-sectional study, all patients presenting to the ED of an urban, Level 1 trauma center for one month were prospectively screened by trained research associates. When an intoxicated patient was identified, study information including patient demographics, diagnoses, vital signs, blood alcohol concentration (BAC), GCS on arrival, ability to ambulate independently on arrival, use of physical or chemical restraint, previous ED visits, length of stay, and health insurance was collected. Data was analyzed using descriptive statistics.

Official Title
-----------------
Prevalence of Chronic Inebriates to the Emergency Department and Suitability for Sobering House Services

Conditions
-----------------
Alcohol Intoxication

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients in the emergency department for alcohol intoxication Exclusion Criteria: Under 18 Prisoners Pregnancy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Intoxicated patients<br>patients in the Emergency Department who appear to be intoxicated with ethanol. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intoxicated Patients Eligible for a Sobering House | Determine the proportion of patients in the emergency department that are intoxicated and how many of those would be eligible to go to a sobering house. Eligibility for a sobering house is at the discretion of the treating physician and includes the ability to ambulate without assistance and no further acute need for medical treatments. | Eligibility for a sobering house is assessed during the current ED admission. The study ends when patient is discharged from the ED, an expected average time of 9 hours. |