The Effect of 10-Week Exercise Training on Children With Asthma

Study Overview
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Brief Summary
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The goal of this research is to determine whether 10-weeks of exercise training can benefit asthmatic children and young adults with a history of exercise-induced bronchoconstriction (EIB). The investigators will also study an exciting newly discovered aspect of gene expression regulation in the white blood cells known as epigenetics: a process that takes place when genomic changes happen as a result of exposure to the environment. This study is based on emerging exciting new data from this and other laboratories demonstrating that (a) white blood cells play an important role in bronchoconstriction in children, (b) gene and cytokine expression in circulating white blood cells are abnormal in asthma and (c) brief exercise may change genomic and inflammatory- profiles of these cells.Physical activity is an essential component of growth and health in children, thus, this research will lead to improved clinical uses of exercise as preventive and adjunctive therapy in the current epidemic of childhood asthma

Official Title
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Exercise Training in Children and Adults: Mechanisms of Allaying Inflammation in Asthma

Conditions
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Asthma in Children

Intervention / Treatment
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* Other: Exercise Training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Good health Physical activity No evidence of disease or disability Diagnosed with persistent asthma (asthma subjects) BMI<95 percentile Exclusion Criteria: Use of illegal drugs or alcohol Very high physical fitness Pregnancy More than two asthma attack per week (asthma subjects)

Ages Eligible for Study
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Minimum Age: 8 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Healthy Subjects<br>Healthy control group which received the same exercise training intervention as the experimental group | Other: Exercise Training<br>* Physical activity in children and adults with asthma.<br>|
| Experimental: Subjects with Asthma<br>Subjects with asthma who received exercise training | Other: Exercise Training<br>* Physical activity in children and adults with asthma.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gene and microRNA expression will be compared between healthy and asthmatic subjects | Monocyte gene expression profiling before and after acute bout of exercise before and after 10-week exercise intervention is gauged using RNA seq in a group of children with asthma and age and sex match healthy controls | 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pro/anti-inflammatory cytokines and markers of oxidative stress will be compared between the groups | Absolute values of cytokines, growth hormones, and other biomarkers will be measured by flow cytometry and statistically analyzed. | 12 weeks |