Neurobehavioral Functioning in Pediatric Brain Tumor Patients After Proton Beam Radiation Treatment

Study Overview
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Brief Summary
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The aim of this study is to follow up with all of the pediatric brain tumor patients who received proton beam radiation therapy at Massachusetts General Hospital (MGH) for which there is baseline neuropsychological testing in order to measure changes, if any, in neurobehavioral functioning (executive skills, emotional/behavioral functioning, and adaptive abilities) and their use of special education services at one year or more post-treatment. The investigators will also correlate neurobehavioral data with pertinent clinical information. Participation will be maximized through the use of mail-in, parental- and self-report questionnaires.

Detailed Description
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The purpose of this study is to longitudinally examine neurobehavioral functioning outcomes and use of special education services in brain tumor and CNS tumor patients treated with proton radiation at MGH. Furthermore, we seek to correlate neurobehavioral data with pertinent clinical information. We anticipate better neurobehavioral functioning to be associated with use of protons (vs. photons, as reported in the literature). We also anticipate the need and utilization of special education services to be lower in brain and CNS tumor patients treated with protons (vs. photons, as reported in the literature). Lastly, we anticipate greater neurobehavioral deficits in patients whose proton radiation treatment involved the craniospinal axis compared to those who received proton radiation to the involved field.

Official Title
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Neurobehavioral Functioning and Utilization of Special Education Services in Pediatric Brain and CNS Tumor Patients After Proton Radiation Treatment: A Longitudinal Study

Conditions
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Brain Tumor, Central Nervous System Neoplasms

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children diagnosed with brain or CNS tumors and treated with proton radiation therapy at the MGH Francis H. Burr Proton Center since September 2002 Patients received baseline neurocognitive testing at MGH Patients ≤25 years at the time of diagnosis Tumor location in the brain or CNS Radiation treatment consisted of only proton radiotherapy No prior radiation exposure or chemotherapy Exclusion Criteria: Patients receiving treatment with palliative intent Patients who do not wish to participate Patient is deceased at ≥1 year follow-up

Ages Eligible for Study
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Minimum Age: 1 Year
Maximum Age: 25 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Proton Radiation Patients at MGH<br>Pediatric brain and central nervous system (CNS) tumor patients treated with proton beam radiation therapy | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Behavior Rating Inventory of Executive Functioning | Questionnaire of executive functioning in children and young adults | Approximately one year post proton radiation treatment | 
| Behavior Assessment System for Children | Questionnaire of behavioral functioning in children and young adults | Approximately one year following proton radiation treatment | 
| Scales of Independent Behavior-Revised | Questionnaire of adaptive skills in children and young adults | Approximately one year following proton beam radiation therapy | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Proton Radiation, CNS tumors, Brain Tumors, Neurobehavioral functioning