Comparison of Inflammatory Responses Subsequent to Different Cesarean Section Techniques

Study Overview
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Brief Summary
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In this study, the investigators aimed to find out whether there are any differences in inflammatory reactions occured subsequent to two different cesarean delivery techniques; modified Misgav-Ladach vs Pfannenstiel-Kerr techniques.

Detailed Description
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Cesarean section is one of the most undertaken operations in women of childbearing age. However, there is not a unique cesarean surgery technique. Pfannenstiel , reported his own technique in 1897. Because of the applicability of the technique, it went down well among obstetricians. After three decades, Kerr evolved this technique, and Pfannenstiel-Kerr technique became the method of choice until late 70's. In 1972, Stark et al defined the Misgav Ladach technique and in the following years this technique became popular among obstetricians. In late 80's Misgav Ladach technique was modified and started to be more popular. But, still Pfannenstiel-Kerr technique continued to be used frequently and studies comparing clinical outcomes of these two techniques were conducted for several times. However, the inflammatory responses which occured subsequent to application of these techniques were not investigated. This is the first study investigating the inflammatory response emerged after different cesarean surgery techniques.

Official Title
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Comparison of Inflammatory Reactions Following Two Different Cesarean Surgery Techniques; The Modified Misgav-Ladach Versus the Pfannenstiel-Kerr Technique

Conditions
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Delivery, Cesarean Delivery, Inflammation

Intervention / Treatment
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* Procedure: cesarean section(C/S) via the modified Misgav-Ladach technique
* Procedure: cesarean section via the Pfannenstiel-Kerr technique


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Cesarean section for the first time Term,singleton pregnancy Exclusion Criteria: Any inflammatory disease Any pregnancy complication; IUGR,preeclampsia,preterm labor,preterm premature rupture of membranes Pregnancies <37weeks gestational age

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Misgav-Ladach<br>cesarean section(C/S) via the modified 'Misgav-Ladach' technique | Procedure: cesarean section(C/S) via the modified Misgav-Ladach technique<br>* the first consecutive 44 patients underwent C/S via the modified Misgav-Ladach technique<br>|
| Active Comparator: Pfannenstiel-Kerr<br>cesarean section(C/S) via the 'Pfannenstiel-Kerr' technique | Procedure: cesarean section via the Pfannenstiel-Kerr technique<br>* the second consecutive 44 patients underwent C/S via the Pfannenstiel-Kerr technique<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| IL-6 | percentage of difference in serum IL-6 levels just before the beginning of the surgery and at the 24th hour of the surgery | 24 hours | 
| TNF-alpha | percentage of difference in serum IL-6 levels just before the beginning of the surgery and at the 24th hour of the surgery | 24 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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TNF, inflammatory reaction, IL-6, Misgav Ladach technique, Pfannenstiel-Kerr technique, cesarean delivery, cesarean technique