Audition After a Lesion and in Migraine. (AuditionPostLesion)

Study Overview
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Brief Summary
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The project studies auditory processing after brain damage (in temporal and/or frontal areas) and in migraine. The auditory processes investigated are attention, short-term memory, sound-induced emotions. To characterize auditory deficits after brain damage or in migraine, neuropsychological assessments are combined with neurophysiological markers (Electro-encephalography: EEG, Magneto-encephalography: MEG, Magnetic Resonance Imaging: MRI).

Official Title
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Consequences of a Brain Lesion or of Migraine on Auditory Processing: Attention, Memory and Emotion

Conditions
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Migraine Disorders, Brain

Intervention / Treatment
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* Other: Neuropsychological tests
* Other: Neurophysiological tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age from 18 to 80 MEG/MRI compatibility Motivation to participate efficiently in the study No severe hearing loss Informed consent to participate in the study Affiliation to social security For brain-damaged patients : no need for medical assistance; focal temporal and/or frontal lesion; no major cognitive impairment; ability to understand and apply the instructions for neuropsychological testing; testing at least one-month after the event resulting in brain damage; absence of neurological and psychiatric disorders besides the lesion For migraine patients: no need for medical assistance; migraine diagnosis; no major cognitive impairment; ability to understand and apply the instructions for neuropsychological testing; absence of neurological and psychiatric disorders besides the migraine Healthy participants: absence of neurological and psychiatric disorders Exclusion Criteria: Age below 18 or above 80 MRI scanning not possible: artificial cardiac pacemaker, insulin pump, metallic prosthesis, intra-cerebral clip, claustrophobia MEG acquisition not possible: large heads, neurostimulator, metal in the head or the body. Pregnant or breast-feeding women

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Brain-damaged patients<br> | Other: Neuropsychological tests<br>* Neuropsychological tests consist in listening to sounds in various contexts and providing behavioral responses with response-buttons.<br>Other: Neurophysiological tests<br>* Neurophysiological tests consist in the recording of EEG and/or MEG signals while realizing the neuropsychological tests, as well as MRI scanning to characterize the patients' brain lesions and reconstruct the brain sources of surface EEG/MEG signals.<br>|
| Experimental: Control participants<br> | Other: Neuropsychological tests<br>* Neuropsychological tests consist in listening to sounds in various contexts and providing behavioral responses with response-buttons.<br>Other: Neurophysiological tests<br>* Neurophysiological tests consist in the recording of EEG and/or MEG signals while realizing the neuropsychological tests, as well as MRI scanning to characterize the patients' brain lesions and reconstruct the brain sources of surface EEG/MEG signals.<br>|
| Experimental: Migraine patients<br> | Other: Neuropsychological tests<br>* Neuropsychological tests consist in listening to sounds in various contexts and providing behavioral responses with response-buttons.<br>Other: Neurophysiological tests<br>* Neurophysiological tests consist in the recording of EEG and/or MEG signals while realizing the neuropsychological tests, as well as MRI scanning to characterize the patients' brain lesions and reconstruct the brain sources of surface EEG/MEG signals.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentages of correct responses in Neuropsychological tests |  | up to 2 months | 
| reaction times in Neuropsychological tests |  | up to 2 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Event-Related Potentials (EEG) in Neurophysiological tests |  | up to 2 months | 
| Event-Related Fields (MEG) in Neurophysiological tests |  | up to 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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EEG, MEG, Audition, Stroke, Migraine, Attention, Short-term memory,, Emotions