linjc16/ctgov huggingface dataset:
Understanding Immunity to the COVID-19 Vaccines

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to test over time immunity to the COVID-19 vaccines. Adults who are receiving COVID-19 vaccines will be invited to participate.

Official Title
-----------------
Understanding Immunity to the COVID-19 Vaccines

Conditions
-----------------
COVID-19, Immunity, Vaccine

Intervention / Treatment
-----------------
* Other: No intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults who are receiving a COVID-19 vaccine Exclusion Criteria: Patients with special risks attendant to venipuncture

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Participants<br>Adults who are receiving a COVID-19 vaccine | Other: No intervention<br>* No intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of participants with immunity to COVID-19 vaccines over time |  | 1 year |
Interest and Impact of Skin Cancer Genetic Testing

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to learn whether the patient might be interested in skin cancer genetic testing, and if so, what kinds of thoughts, feelings, and behaviors might result from this testing. Testing for skin cancer risk based on the MC1R gene is not currently used in clinical practice; it will be offered in this study for research purposes only.

Official Title
-----------------
PERSONALIZED GENOMIC TESTING FOR MELANOMA: MAXIMIZING COMPREHENSION AND HEALTH OUTCOMES IN SKIN CANCER PATIENTS

Conditions
-----------------
Non-melanoma Skin Cancer (NMSC)

Intervention / Treatment
-----------------
* Genetic: MC1R genotyping
* Behavioral: MC1R Testing Website
* Behavioral: Baseline Survey


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years of age or older English fluent as we do not have the resources to translate all the materials including the website and risk feedback materials into other languages Prior history of stage 0, I or II NMSC as per EMR or clinical judgment Exclusion Criteria: Inability to provide meaningful informed consent due to cognitive or psychiatric disability as determined by the judgement of the consenting professional or clinician

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Non-melanoma skin cancers (NMSCs)<br> | Genetic: MC1R genotyping<br> <br> Behavioral: MC1R Testing Website<br>* The website includes three educational modules about genetic testing with corresponding knowledge questions.<br>Behavioral: Baseline Survey<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| number of patients interested in MC1R testing |  | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Genetic Testing, 16-1243
Evaluation of Swallowing in Patients With Obstructive Sleep Apnea

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to test the hypothesis that obstructive sleep apnea syndrome is associated with deviant pharyngeal swallowing function, using clinical, endoscopical and manometric evaluation.

Official Title
-----------------
Clinical, Endoscopical and Manometric Evaluation of Swallowing in Obstructive Sleep Apnea Syndrome

Conditions
-----------------
Sleep Apnea, Obstructive

Intervention / Treatment
-----------------
* Procedure: clinical, endoscopical and manometric evaluation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diagnosis of obstructive sleep apnea syndrome Exclusion Criteria: other causes of dysphagia pharyngeal surgery prior treatment for obstructive sleep apnea

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: clinical, endoscopical and manometric evaluation|clinical evaluation: questionnaire endoscopical analysis manometry|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical evaluation of swallowing in obstructive sleep apnea |  | within the first 3 months after diagnostic | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Manometric evaluation of swallowing in obstructive sleep apnea |  | within the first 3 months after diagnostic | 
| Endoscopic evaluation of swallowing in obstructive sleep apnea |  | within the first 3 months after diagnostic | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Sleep apnea, obstructive, Deglutition Disorders, Manometry, Endoscopy
The CMCPCTH Research in Chinese Children

Study Overview
=================
Brief Summary
-----------------
To obtain hemorrhage rate after coblation tonsillectomy, and to investigate risk factors of hemorrhage after coblation tonsillectomy in children.

Detailed Description
-----------------
This study is a prospective and multi-centre trail in China. It intends to enroll 25000 patients underwent coblation tonsillectomy in 22 clinical centers in China. Hemorrhage rate and risk factors of hemorrhage after coblation tonsillectomy will be investigated through questionnaires.

Official Title
-----------------
A Multi-centre Clinical Study of Hemorrhage Rate After Coblation Tonsillectomy in Children

Conditions
-----------------
Tonsillectomy, Child, Postoperative Hemorrhage

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: under 18 years old; Clear indications for tonsill surgery; No clear contraindications for tonsill surgery; Parents of the children patients accept surgical treatment; Parents of the children patients able to cooperate with the visit and follow-up. Exclusion Criteria: Children patients with a history of adenoid or tonsillectomy surgery; Associated with refractory bleeding diseases; Combined with cleft palate; Down syndrome, Prader-Willi syndrome (PWS) or other chromosomal abnormalities; Neuromuscular diseases (including cerebral palsy); Other diseases that affect physical health, such as severe heart disease, kidney disease, lung disease, etc; Contraindications to surgery and anesthesia; Unable to obtain informed consent.

Ages Eligible for Study
-----------------
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hemorrhage rate after coblation tonsillectomy | hemorrhage rate after coblation tonsillectomy in children within 3 weeks | 3 weeks after surgery | 
| risk factors of hemorrhage after coblation tonsillectomy | risk factors of hemorrhage after coblation tonsillectomy in children | 3 weeks after surgery | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Tonsillectomy, child, Postoperative Hemorrhage, low-temperature plasma radiofrequency ablation
Topical Hydromorphone for Wound Healing

Study Overview
=================
Brief Summary
-----------------
The hypothesis is that topical opioids will hasten wound healing in humans.

Detailed Description
-----------------
This is based on our published data that morphine is a powerful stimulant of angiogenesis and our preclinical study of wounds in rats which demonstrate that topical opioids (morphine, hydromorphone and fentanyl) hasten healing of punch biopsy wounds. This study will focus on hydromorphone which was more powerful than morphine as a wound-healer in the rat study.

Official Title
-----------------
Topical Hydromorphone for Wound Healing

Conditions
-----------------
Wound Healing

Intervention / Treatment
-----------------
* Drug: hydromorphone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Self-identified as normal, healthy volunteers age 18-65. Exclusion Criteria: Known bleeding disorder.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: hydromorphone|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Healing rates and microvessel density will be compared statistically for the control-ointment versus hydromorphone-ointment subjects. |  |  |
Muscle Glycogen Synthesis When Caffeine and Protein is Co-Ingested With Carbohydrates

Study Overview
=================
Brief Summary
-----------------
The aim of the present study is to investigate the effect of added protein+leucine or caffeine to 1.2 g/kg/h CHO on the rate of post-exercise muscle glycogen re-synthesis in healthy, recreational athletes. The investigators hypothesize that both interventions (the addition of caffeine or protein+leucine) will lead to higher glycogen re-synthesis compared to the ingestion of CHO only, and that the co-ingestion of protein and leucine will result in the highest muscle glycogen synthesis rates.

Official Title
-----------------
The Effect of Caffeine or Protein Co-ingestion With Carbohydrate on Post-exercise Muscle Glycogen Synthesis Rate.

Conditions
-----------------
Exercise Recovery

Intervention / Treatment
-----------------
* Dietary Supplement: Carbohydrate
* Dietary Supplement: Carbohydrate and protein ingestion
* Dietary Supplement: Carbohydrate and caffeine ingestion


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: male cyclists healthy BMI < 25 Exclusion Criteria: female use of medication non cycling BMI > 25

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Carbohydrate ingestion | Dietary Supplement: Carbohydrate<br>* 1.2 g/kg/h<br>|
| Experimental: 2<br>Carbohydrate and protein ingestion | Dietary Supplement: Carbohydrate and protein ingestion<br>* 1.2 g/kg/h carbohydrate plus 0.4 g/kg/h protein<br>|
| Experimental: 3<br>Carbohydrate and caffeine ingestion | Dietary Supplement: Carbohydrate and caffeine ingestion<br>* 1.2 g/kg/h carbohydrate and 1.67 g/kg/h caffeine<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle glycogen synthesis rates |  | 6 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glycogen synthase activity, plasma glucose, insulin, free fatty acids and epinephrine responses |  | 6 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Glycogen, Carbohydrate, Protein, Caffeine, Post exercise muscle glycogen synthesis, Sports nutrition
Stiffness Measurement of Liver Tumors and Visceral Parenchyma

Study Overview
=================
Brief Summary
-----------------
The investigators are measuring hepatocellular carcinoma(HCC)stiffness using Acoustic Radiation Force Impulse (ARFI) technique to enhance the diagnostic accuracy for HCC stratifications and treatment efficacy.

Detailed Description
-----------------
Regression modelings as well as validity testings including cut-off identification will be acquired by performing both qualitative and quantitative measurements of HCC using reference diagnostic modalities e.g. pathology grading, dynamic CT scanning, etc.

Official Title
-----------------
Clinical Applications of Acoustic Radiation Force Impulse Technology in Stiffness Measurement of Liver Tumors and Visceral Parenchyma

Conditions
-----------------
Hepatocellular Carcinoma

Intervention / Treatment
-----------------
* Other: stiffness measurement using ARFI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: with HCC Exclusion Criteria: subjects with liver cancer other than HCC subjects with treated HCC post major abdominal surgery contraindications to liver tumor biopsy contraindications to local percutaneous treatment of liver tumors ARFI measurement low quality

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| newly diagnosed HCC<br>Subjects with newly diagnosed untreated hepatocellular carcinoma (HCC) will be enrolled. Subjects with the following conditions will be excluded: liver cancer other than HCC, treated HCC, post major abdominal surgery, contraindications to liver tumor biopsy, contraindications to local percutaneous treatment of liver tumors, low quality ARFI measurement | Other: stiffness measurement using ARFI<br>* Stiffness measurement will be performed for HCC using ARFI technique.<br>* Other names: Acuson S2000;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
hepatocellular carcinoma, stiffness
Normative Value for Navicular Drop Test in Older Adults

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to determine the normative values of navicular height and navicular drop in individuals over 65 years of age. The secondary aim is to investigate the effects of age, gender, and body mass index on these normative values.

Official Title
-----------------
Determination of Normative Values of Navicular Height and Navicular Drop Amount in Geriatric Individuals and Investigation of the Effect of Age, Gender and Body Mass Index on Normative Values

Conditions
-----------------
Healthy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Being 65 years or older Having a body mass index between 18.5 and 29.0 kg/m2 Exclusion Criteria: Having chronic diseases that affect the foot structure and connective tissue (such as diabetes mellitus, rheumatoid arthritis, gout, etc.). Have had foot or ankle surgery in the last 6 months Having orthopedic or neurological deformities (related to stroke, Parkinson's, multiple sclerosis, spinal cord injury, etc.) that will affect the foot structure and mobility. Dependence on standing and ambulation (except independence gained through the use of assistive devices)

Ages Eligible for Study
-----------------
Minimum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Young older adults<br>≥65-<75 years of age | |
| Older adults<br>≥75-<90 years of age | |
| ≥90 years old<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Navicular Drop Test | The navicular height and the amount of navicular drop will be made separately for each foot. The navicular prominence is found by palpation and marked with a marker pen when the individual is in a sitting position with the hips and knees flexed to 90 degrees and the subtalar joint in neutral position (the subtalar joint is palpated and the talus is in a neutral position). The height of the navicular protrusion from the ground is measured with a rigid ruler. Then, while the person stands on both feet equally, the height of the navicular protrusion from the ground is also measured with a ruler. The difference between the two measurements is noted as the amount of navicular drop (NDT). | 10 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Age | Age | 1 minute | 
| Gender | Gender | 1 minute | 
| Body-Mass index | weight/ (height)2 | 3 minutes | 
| Foot Posture Index | FPI | 15 minutes |
Local Anaesthesia Used During Fast-track Colonic Surgery: Evaluation of Bupivacaine and Levobupivacaine in Practice

Study Overview
=================
Brief Summary
-----------------
The standard treatment for post operative pain is now bupivacaine + sufentanil. The use of this combination during fast-track colonic surgery leads frequently to post-operative nausea and vomiting and limited mobilisation possibilities. Therefore the department anaesthesiology wants to evaluate the use of a different local anaesthetic: levobupivacaine combined with morphine on demand. The expectation is that the use of levobupivacaine leads to less side effects.

Official Title
-----------------
Local Anaesthesia Used During Fast-track Colonic Surgery: Evaluation of Bupivacaine and Levobupivacaine in Practice

Conditions
-----------------
Colonic Diseases, Post-operative Pain, Local Anesthesia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients who undergo fast-track colonic surgery and with post operative epidural pain treatment Exclusion Criteria: Patients who are admitted to an other ward Patients with a spinal catheter
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Bupivacaine<br>Patients who received bupivacaine + sufentanil | |
| Levobupivacaine<br>Patients who received levobupivacaine and morphine on demand | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Post-operative pain treatment, Fast-track colonic surgery patients, Surgery
Learning and Coping With Chronic Illness

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether the participants have improved their scores on health related quality of life (HRQL) 1 year after completing a learning and mastery course and whether sociodemographic variables are associated with HRQL.

Detailed Description
-----------------
Persons with chronic illnesses have to adjust to changes in their life-style. In the last 10 years Learning and Mastery Centres have been established in Norwegian hospitals to offer patient education for the chronically ill. It is not known whether these courses impact any changes in HRQL 1 year after course completion.

Official Title
-----------------
Learning and Coping With Chronic Illness

Conditions
-----------------
Morbid Obesity

Intervention / Treatment
-----------------
* Behavioral: Teaching life style changes
* Other: Active participation
* Other: Teaching


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: diagnosis of morbid obesity attending learning and mastery course for the obese

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Morbid obesity<br>All attending learning and mastery courses for persons with morbid obesity | Behavioral: Teaching life style changes<br>* Single group: Teaching, group sessions, physical activity<br>Other: Active participation<br>* Obesity group attend 10 group sessions,are informed about and discuss needed life style changes such as weight loss and participate in physical activity and cooking.<br>Other: Teaching<br>* Morbid obesity group attend 40 hours of group sessions<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health related quality of life |  | 1 year after course completion | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Morbid obesity, Patient education