Diagnosis and Treatment of Minor Ischaemic Stroke According to the Etiology and Pathogenesis

Study Overview
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Brief Summary
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Negligence or contempt of the etiology and pathogenesis of minor ischaemic stroke in the early diagnosis and effective treatment leads to more than 40-50% of patient with recurrent episodes, and 10% patient died. Therefore, diagnosis and treatment of minor ischaemic stroke according to the etiology and pathogenesis is important. The 2007 Korean modified TOAST type got some progress, but there exists two major disadvantages: imperfect diagnosis and pathogenesis of perforator artery infarction etiology; lack of typing according to the pathogenesis of large atherosclerotic infarction and taking measures of treatment according to the new types. Recently, domestic professor Gaoshan proposes new approach to diagnose and treat minor ischaemic stroke according to the etiology and pathogenesis of CISS typing, but the pathogenesis of hypoperfusion infarction with severe stenosis of large artery is unclear. Is it low perfusion? Or artery-artery embolization? Or both? How to distinguish the pathogenesis of branch artery disease: by atherosclerosis? Or hyalinosis? Or both? How to check the validity of clinical types? This study take different interventions according to different types and observation of the long term clinical results of intervention( mortality, recurrence rate, disability rate and rate of cerebral hemorrhage and subarachnoid hemorrhage), in order to clarify the new types can indeed solve the current problem of minor ischaemic stroke with high mortality, recurrence rate, disability rate and rate of cerebral hemorrhage and subarachnoid hemorrhage.

Official Title
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Diagnosis and Treatment of Minor Ischaemic Stroke According to the Etiology and Pathogenesis

Conditions
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Ischaemic Stroke

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: one of two conditions: conscious patients with any of NIHSS score = 1,or NIHSS ≤ 3 Exclusion Criteria: patients Over 80 years of age patients With serious heart, lung, liver, kidney dysfunction or severe systemic complications, a known tumor, pregnancy, having a history of cerebral hemorrhage

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 79 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| artery-artery embolus<br>There is no hypoperfusion ( contralateral compensatory is good ) | |
| Hypoperfusion<br>Contralateral compensatory not sufficient | |
| Hypoperfusion and embolus amotic<br>Hypoperfusion and embolus amotic | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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etiology, pathogenesis, minor ischaemic stroke, types, intervention