Acute Myocardial Infarction: Prognostic and Therapeutic Evaluation

Study Overview
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Brief Summary
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AMIPE is both a retrospective and prospective study which was designed in order to collect data of patients with acute coronary syndromes and myocardial injury and to improve the knowledge about these conditions.

Detailed Description
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AMIPE is an observational, multicenter and both retrospective and prospective study enrolling a cohort of consecutive incident patients admitted to participating hospitals with a diagnosis of acute coronary syndrome or myocardial injury from 01/01/2016 to 31/12/2023. The aim of this study is to create a database including a comprehensive characterization of these patients in order to obtain new scientific evidence about these conditions. Informations about the patients will be gathered from in-hospital medical records. A written informed consent is needed for every prospective patients enrolled in the study, In particular, the main objectives of the study are: document the characteristics of all patients presenting with acute coronary syndrome and myocardial injury; document the long term outcome rates; document the therapeutic regimens and investigation conformity of treatment with already established guidelines. Every diagnostic or therapeutic intervention will be in accordance with established guidelines and good clinical practice. Statistics will be conducted utilizing univariate and multivariate analysis for outcomes. In particular for what concerns univariate analysis, ordinal variables will be analysed with t-test and Mann-Whitney Test, whereas categorical responses with Fischer Exact Test and with Pearson Chi-square test. Multivariate analysis will be conducted with logistic regression for dichotomous variables, with mixed generalized linear model for ordinal or nominal variables and with ANOVA or MANOVA for continuous variables.

Official Title
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Acute Myocardial Infarction From Clinical Presentation to Strategy Treatment

Conditions
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Acute Coronary Syndrome, Myocardium; Injury

Intervention / Treatment
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* Other: Database


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient aged > 18 years old Acute coronary syndrome or myocardial injury Written informed consent Exclusion Criteria: under age or not able to give informed consent

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients with acute coronary syndrome or myocardial injury<br>Incident consecutive patients presenting with acute coronary syndrome or myocardial injury | Other: Database<br>* Create a database containing clinical characteristic, clinical presentation, flow indexes and treatment of consecutive incident patients with ACS or myocardial injury.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| All cause mortality | Death rate | 1 year | 
| All cause mortality | Death rate | 3 years | 
| All cause mortality | Death rate | 5 years | 
| Major Adverse Cardiac Events (MACEs) | MACEs rate | 1 year | 
| Major Adverse Cardiac Events (MACEs) | MACEs rate | 3 years | 
| Major Adverse Cardiac Events (MACEs) | MACEs rate | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiovascular risk factors prevalence | Differences in percentage of patients with STEMI or NSTEMI, or type 1 or type 2 myocardial infarction with any risk factors | 1 year | 
| Cardiovascular risk factors prevalence | Differences in percentage of patients with STEMI or NSTEMI, or type 1 or type 2 myocardial infarction with any risk factors | 3 year | 
| Cardiovascular risk factors prevalence | Differences in percentage of patients with STEMI or NSTEMI, or type 1 or type 2 myocardial infarction with any risk factors | 5 year | 
| Differences in clinical presentation | Prevalence of patients presenting with ST elevation, angina, dyspnea, atypical chest pain, cardiogenic shock, arrhytmias) | 3 year | 
| Differences in clinical presentation | Prevalence of patients presenting with ST elevation, angina, dyspnea, atypical chest pain, cardiogenic shock, arrhytmias) | 1 year | 
| Differences in clinical presentation | Prevalence of patients presenting with ST elevation, angina, dyspnea, atypical chest pain, cardiogenic shock, arrhytmias) | 5 year | 
| Difference diagnosis between myocardial infarction subtypes and between myocardial infarction and myocardial injury | Differences in clinical presentation (ST elevation, angina, dyspnea, atypical chest pain, cardiogenic shock, arrhytmias) | 5 year | 
| Differences in flow characteristics | TIMI, TIMI frame count | 1 year | 
| Differences in flow characteristics | TIMI, TIMI frame count | 3 year | 
| Differences in flow characteristics | TIMI, TIMI frame count | 5 year | 
| Differences and impact of periprocedural ischemic complications | Type 4a myocardial infarction, periprocedural myocardial injury | 5 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ACS, Acute coronary syndrome, Myocardial injury, MINOCA