The ENDOCARDITIS AUMC Data Collection

Study Overview
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Brief Summary
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The investigators will compare patients with and without infective ndocarditis undergoing valve surgery and evaluate factors that may help optimise perioperative care of these high-risk patients.

Detailed Description
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The aim of this study is to examine the differences between patients with and without endocarditis who undergo cardiothoracic (valve) surgery. In addition, the investigators will look at the differences between endocarditis patients who undergo surgery, and those who are treated conservatively. The investigators will look at incidence and degree of perioperative coagulation abnormalities, as well as transfusion and coagulation factor requirements, heparin resistance, bleeding scores, predictive endocarditis mortality scores, vasopressor-inotrope scores, and relate these where possible to the pathogen causing IE. The investigators will also look at perioperative complications, in particular, thromboembolic events and mortality at 30 and 90 days, and at 1 year. These outcomes may help optimise perioperative care for high-risk endocarditis patients, and in particular those undergoing valve surgery.

Official Title
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The ENDOCARDITIS AUMC Data Collection : a Matched Cohort Study on Perioperative Coagulation in Conservatively and Surgically Treated Patients With Valvular Dysfunction, With and Without Infective Endocarditis

Conditions
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Endocarditis, Coagulation Disorder, Valve Disease, Heart

Intervention / Treatment
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* Other: None, observational


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients > 18 years Dutch or English speaking All patients with infective endocarditis admitted to Amsterdam UMC in the study period All patients with infective endocarditis scheduled for cardiac valve surgery compared to a matched cohort of patients scheduled for similar surgery due to non-infectious indication in Amsterdam UMC in the same period Exclusion Criteria: Previous history of coagulation disorders

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Infective endocarditis, surgical arm<br>Patients with infective endocardits requiring valve surgery | Other: None, observational<br>* Patients with infective endocarditis who do and do not undergo valve surgery compared with patientswithout endocarditis, who are operated on with similar valve surgery<br>|
| Infective endocarditis, conservative arm<br>Patients with infective endocardits, not requiring valve surgery | Other: None, observational<br>* Patients with infective endocarditis who do and do not undergo valve surgery compared with patientswithout endocarditis, who are operated on with similar valve surgery<br>|
| Valve disease, heart, surgically repaired<br>Patients requiring valve surgery | Other: None, observational<br>* Patients with infective endocarditis who do and do not undergo valve surgery compared with patientswithout endocarditis, who are operated on with similar valve surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Thromboembolic complications | Any thromboembolic complications occuring between surgery and 1 year post operatively (incidence, class and severity) | up to 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of perioperative coagulation abnormalities | How often perioperative coagulation abnormalities, measured by classical laboratory values and rotational thromboelastometry are seen from diagnosis to 24 hours post-surgery | First 24 hours after surgery | 
| Differences in incidence of pathogens and the relation with disease severity | To evaluate the effect of different pathogens (evaluated by laboratory results) on the clinical status | Up to 30 days |