Endocannabinoid and Psychological Responses to Yoga in Healthy Adults

Study Overview
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Brief Summary
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This study evaluates the acute effect of yoga on plasma levels of endocannabinoids and mood (i.e., mood disturbance, anxiety, pain) compared to one session of quiet rest. Participants completed one session of yoga and one session of quiet rest on two separate days.

Official Title
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Endocannabinoid and Psychological Responses to Yoga in Healthy Adults

Conditions
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Healthy

Intervention / Treatment
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* Behavioral: Yoga
* Behavioral: Quiet Rest


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: greater than or equal to 18 years old and < 45 years old and report being healthy. Exclusion Criteria: Being pregnant or planning to become pregnant, currently smoking, having a history of light headedness or fainting during blood draws or physical activity, having a history of chest pain during physical activity, having a bone, joint, cardiac, or other medical condition that a doctor has said may be worsened by physical activity, taking medications for any chronic diseases such as high blood pressure or diabetes, responding 'Yes' to any of the seven questions on the Par-Q.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: The proposed study is an acute, single group, crossover pilot study where participants will complete control and experimental conditions.
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Yoga<br>40 minutes of Vinyasa yoga | Behavioral: Yoga<br>* 1 session<br>|
| Placebo Comparator: Quiet Rest<br>40 minutes of quiet rest | Behavioral: Quiet Rest<br>* 1 session<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Plasma Concentration of N-arachidonoylethanolamine | Plasma concentration of anandamide, one effector of the endocannabinoid system | This will be measured 2 times during each study visit, once before the assigned study task (i.e., baseline) and once upon task completion (i.e., approx. 40 min. later) | 
| Change in Plasma Concentration of 2-Arachidonoylglycerol (2-AG) | Plasma concentration of 2-AG, one effector of the endocannabinoid system | This will be measured 2 times during each study visit, once before the assigned study task (i.e., baseline) and once upon task completion (i.e., approx. 40 min. later) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Total Mood Disturbance as Measured by the Profile of Mood States | 65-item self-reported mood questionnaire that measures mood right now. Scores range from 0-200 with higher scores indicating higher mood disturbance. | This will be measured 2 times during each study visit, once before the assigned study task (i.e., baseline) and once upon task completion (i.e., approx. 40 min. later) | 
| Change in State Anxiety as Measured by the State-Trait Anxiety Inventory | 20-item self-reported anxiety questionnaire that measures anxiety right now. Scores range from 20-80 with higher scores indicating higher anxiety. | This will be measured 2 times during each study visit, once before the assigned study task (i.e., baseline) and once upon task completion (i.e., approx. 40 min. later) | 
| Change in Total Pain as Measured by the Short-form McGill Pain Questionnaire | 15-item self-reported pain questionnaire that measures pain right now. Scores range from 0-45 with higher scores indicating higher pain. | This will be measured 2 times during each study visit, once before the assigned study task (i.e., baseline) and once upon task completion (i.e., approx. 40 min. later) |