National Cerebral and Cardiovascular Center (NCVC) Stroke Registry

Study Overview
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Brief Summary
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A single-center registry of patients with acute ischemic stroke, intracerebral hemorrhage, and transient ischemic attack (TIA) who are emergently managed in the stroke care unit in the National Cerebral and Cardiovascular Center (NCVC) to determine change in underlying characteristics, stroke features and severity, process for diagnosis and acute treatment, and long-term outcomes of stroke/TIA patients over the years.

Detailed Description
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This is a single-center registry of consecutive patients with acute ischemic stroke, intracerebral hemorrhage, and transient ischemic attack (TIA) who are emergently managed in the stroke care unit in the National Cerebral and Cardiovascular Center, a flagship stroke center in Japan. Neurological emergencies other than stroke/TIA and subclinical cerebrobvascular inpatients are also enrolled. Data are collected and analyzed to determine change in underlying characteristics, stroke features and severity, process for diagnosis and acute treatment, and long-term outcomes of stroke/TIA patients over the years. The National Cerebral and Cardiovascular Center was founded in 1977 in Suita, Osaka, in order to provide the public with the most advanced treatment for cardiovascular and cerebrovascular diseases and to conduct the highest level of basic as well as applied research on the cardiovascular and cerebrovascular systems.

Official Title
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National Cerebral and Cardiovascular Center (NCVC) Stroke Registry

Conditions
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Stroke, Acute

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: A patient with acute ischemic stroke, intracerebral hemorrhage, and transient ischemic attack who are emergently managed in the stroke care unit or stroke units in the National Cerebral and Cardiovascular Center (NCVC) Consent to participate in the registration by a patient or relatives obtained using an opt-out approach by the demonstrating contents of the registration on the hospital bulletin board Exclusion Criteria: 1) Patients considered by the investigator to be unsuitable for participating in this registry
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Acute ischemic stroke, acute ICH, TIA<br>Consecutive patients with acute ischemic stroke, intracerebral hemorrhage, and transient ischemic attack who are emergently managed in the stroke care unit or stroke units in the National Cerebral and Cardiovascular Center | Other: No intervention<br>* a single-center prospective observational study<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The modified Rankin Scale (mRS), a measure of disability | mRS scores range from 0 (no symptoms at all) to 6 (death) | 3 monhts | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of participants | Also assessing underlying patients' characteristics prior to index stroke/TIA | at entry | 
| National Institutes of Health Stroke Scale score | Also assessing neurological and cognitive states | at entry | 
| Volume of culprit infarcts/hematoma | ASPECTS on DWI for ischemia or hematoma volume using the ABC/2 method | at entry | 
| The modified Rankin Scale (mRS), a measure of disability | mRS scores range from 0 (no symptoms at all) to 6 (death). Participants will be followed at hospital discharge, an expected average of 3 weeks. | around 3 weeks | 
| The modified Rankin Scale (mRS), a measure of disability | mRS scores range from 0 (no symptoms at all) to 6 (death) | 1 year | 
| Events of cardiovascular diseases including stroke/TIA | Participants will be followed at hospital discharge, an expected average of 3 weeks. | around 3 weeks | 
| Events of cardiovascular diseases including stroke/TIA |  | 3 months | 
| Events of cardiovascular diseases including stroke/TIA |  | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Acute ischemic stroke, Acute intracerebral hemorrhage, Transient ischemic attack