Brainstem Grey Matter and Cerebral Autoregulation in Migraine With Aura.

Study Overview
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Brief Summary
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Migraine with aura (MA) is an independent risk factor for stroke and is associated with silent brain infracts and T2 white matter hyperintensities on MRI. Previous studies using Transcranial Doppler (TCD) have shown an impairment of cerebral autoregulation in MA patients. Studies with positron emission tomography have demonstrated an activation of brain stem areas during migraine attack. An increased density of brain stem grey matter as measured on MRI with voxel based morphometry (VBM) has been found in MA patients. As brain arteries and arterioles are innervated by ascending tracts from aminergic brainstem nuclei, th study hypothesize a negative correlation between the density of brainstem nuclei and the efficiency of cerebral autoregulation in MA patients compared with controls. Brainstem grey matter density will be studied with a MRI Philips 3 Tesla with a 32-channel antenna and voxel-based morphometry (VBM) cerebral autoregulation will be measured in the time domain using Transcranial Doppler (TCD) and the Mx method. MA patients will be studied in a headache-free period. MRI and Transcranial Doppler (TCD) are non-invasive technics and will be performed on the same day.

Official Title
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Brainstem Grey Matter and Cerebral Autoregulation in Migraine With Aura : a MRI and Transcranial Doppler.

Conditions
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Migraine With Aura

Intervention / Treatment
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* Other: Magnetic resonance imaging
* Other: Transcranial Doppler


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Migraine with aura patients : fulfilling the International Classification of Headache Disorders-3 beta criteria of MA Control group : Gender- and age-matched subjects without history of migraine with or without aura or any other headache Exclusion Criteria: History of illness or injury of central or peripherical nervous system Previous history of a disease potentially impairing cerebral autoregulation (diabetes, sleep apnea syndrome, uncontrolled hypertension, cardiac arrhythmia, hearth failure, carotid stenosis) Contraindications related to MRI Absence of temporal acoustic window Pregnancy

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Migraine with aura Patients<br>Patients with migraine with aura will be studied 30 days after the pre inclusion visit with both magnetic resonance imaging and Transcranial Doppler. | Other: Magnetic resonance imaging<br>* Patients and controls will first be studied with MRI. The total duration of MRI is about 60mn. These technic is not invasive.<br>Other: Transcranial Doppler<br>* Patients and controls will first be studied with TCD. The total duration of TCD is about 60mn. These technic is not invasive.<br>|
| Other: Controls<br>Control group with healthy volunteers will be studied 30 days after the pre inclusion visit with both magnetic resonance imaging and Transcranial Doppler. | Other: Magnetic resonance imaging<br>* Patients and controls will first be studied with MRI. The total duration of MRI is about 60mn. These technic is not invasive.<br>Other: Transcranial Doppler<br>* Patients and controls will first be studied with TCD. The total duration of TCD is about 60mn. These technic is not invasive.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Correlation between the density of the pontine grey matter evaluated with resonance magnetic imaging, and cerebral autoregulation measured with Transcranial Doppler in migraine with aura patients and controls. | Resonance magnetic imaging use voxel base morphometry and Transcranial doppler use the coefficient mx calculation. | 30 days after the pre-inclusion visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of brainstem grey matter density between migraine with aura patients and controls with magnetic resonance imaging | Comparison will be done with software using voxel based morphometry (VBM) function in addition of imaging with resonance magnetic imaging. | 30 days after pre-inclusion visit | 
| Comparison of cerebral autoregulation between migraine with aura patients and controls with Transcranial Doppler | Comparison will be done using the calculation of mx coefficient in addition of imaging with Transcranial Doppler. | 30 days after pre-inclusion visit | 
| Comparison of cerebrovascular reactivity to carbon dioxide between migraine with aura patients and controls with Transcranial Doppler | Comparison will be done using voluntary apnea test in addition of imaging with Transcranial Doppler. | 30 days after pre-inclusion visit | 
| Comparison of morphological abnormalities between migraine with aura patients and controls with resonance magnetic imaging. | Comparison will be done using T2 white matter hyperintensities and silent brain infracts on resonance magnetic imaging. | 30 days after pre-inclusion visit | 
| Comparison of baroreflex sensitivity between migraine with aura patients and controls with Transcranial Doppler |  | 30 days after pre-inclusion visit | 
| Association between grey matter density and morphological abnormalities on resonance magnetic imaging | Association will be determined using T2 white matter hyperintensities, silent brain infracts and voxel based morphometry function of software | 30 days after pre-inclusion visit | 
| Association between cerebral autoregulation and morphological abnormalities on magnetic resonance imaging | Association will be determined using T2 white matter hyperintensities, silent brain infracts and calculation of mx coefficient | 30 days after pre-inclusion visit | 
| Relation between baroreflex sensitivity and cerebral autoregulation with Transcranial Doppler. | Relation will be determined using the calculation of mx coefficient in addition of imaging with Transcranial Doppler | 30 days after pre-inclusion visit | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Cerebral autoregulation, MRI, VBM, Doppler Transcranial