Effects of Physical Activity, Ambulatory Blood Pressure and Calcium Score on Cardiovascular Health in Normal People

Study Overview
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Brief Summary
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A prospective cohort of relatively healthy individuals, using comprehensive clinical information, advanced imaging (including cardiac MRI), cardiovascular exercise physiology, metabolomics and genetic analysis. These findings will be correlated with adverse clinical outcomes including death, stroke and myocardial infarction. In selected cases, follow-up imaging and biomarker samples will also be obtained. These studies will enable us to begin to address a critical gap in our knowledge as to how best to interpret the very large amount of cardiovascular tests done in Singapore and how to better to predict outcomes and manage healthcare costs in our local populations

Detailed Description
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SingHEART sub-study will collect the following data types or perform the following investigations: Demographic and clinical characteristics data. Basic blood investigations. Basic blood investigations include: FBC, CRP, renal panel, random glucose, LFT, fasting lipids, ESR, CRP, Perform a single baseline cardiac MRI (already consented and obtained as part of the primary study). ECG Calcium score Biobanking (whole blood, plasma and serum, already performed as part of the primary study) Exercise and physical activity tracker over two 1-week periods Ambulatory BP monitoring over two 24-48H periods

Official Title
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SingHEART: Effects of Physical Activity, Ambulatory Blood Pressure and Calcium Score on Cardiovascular Health in Normal People

Conditions
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Myocardial Infarction

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men and women age 21-69 years Exclusion Criteria: Previous myocardial infarction (MI). This will include ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI) Known coronary artery disease - prior coronary revascularization Known documented peripheral arterial disease Previous stroke a. Stroke is defined as new focal neurological deficit persisting more than 24hours21. More than ongoing use of 2 or more anti-hypertensive agents Prior history of cancer (excludes pre-cancerous lesions) Expected life expectancy less than 1 year Known definite diabetes mellitus or on treatment for diabetes mellitus Known autoimmune disease or genetic disease Known endocrine disease on treatment Psychiatric illness Asthma or chronic lung disease requiring long term medications or oxygen Chronic infective disease, including tuberculosis, hepatitis B and C; and HIV Inability to comply with study protocol Any other acute or chronic medical or physical condition deemed by the investigator to affect study outcomes

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 69 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| First cardiovascular event |  | 1 year |