Concurrent Single Gene and 24 Chromosome Aneuploidy Preimplantation Genetic Diagnosis (PGD)

Study Overview
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Brief Summary
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Gene Security Network has developed a novel technology called Parental SupportTM (PS) which is used for Preimplantation Genetic Screening/Diagnosis (PGS/D) during in vitro fertilization (IVF). This technology allows IVF physicians to identify embryos, prior to transfer to the uterus, which have the best chance of developing into healthy children. The purpose of this study is to validate clinical use of PS to detect specific genetic mutation(s) known to cause severe inheritable diseases in embryos produced by at-risk couples. This may be done while simultaneously testing these embryos for aneuploidy. This study will allow for first of its kind commercial PGS/D testing to detect disease-associated genetic mutations together with aneuploidy screening.

Official Title
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First Use of Parental Support Technology(R) for Single Gene Analysis Plus Aneuploidy Screening in Preimplantation Genetic Diagnosis

Conditions
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Any Single Gene Disorder (Cystic Fibrosis, Tay-Sachs)

Intervention / Treatment
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* Other: preimplantation diagnosis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: couple (mother and father)at risk to have a child with a single gene disorder (e.g. cystic fibrosis, Tay-Sachs, sickle cell anemia) Able to provide laboratory report from commercial CLIA certified laboratory confirming presence of disease associated mutation in mother and/or father couple planning to go through IVF and desiring PGD for the specified mutation Father (male) willing and able to provide sperm sample Maternal (female's) age <40 years (e.g., 39 or younger) CVS/Amnio planned once the pregnancy occurs; willing/able to provide amnio/cvs sample for confirmatory testing or provide test results of confirmatory testing performed by an external CLIA certified laboratory. FSH <10 (FSH = Follicle Stimulating Hormone. FSH is an indicator of egg quality and rough predictor of egg stimulation success. FSH is routinely measured by the IVF center prior to beginning an IVF cycle.) Exclusion Criteria: Couples without prior documentation of genetic mutation as specified above Adult couples where the male partner is not willing, able, or available to provide a semen sample. Maternal age >=40 years Couple unwilling to have amnio/cvs

Ages Eligible for Study
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Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: PGD testing<br> | Other: preimplantation diagnosis<br>* genetic testing on embryos to identify embryos that are affected by a single gene disorder (e.g. cystic fibrosis, Tay-Sachs, sickle cell anemia)<br>* Other names: Parental Support Technology;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Confirm diagnosis through prenatal diagnosis (CVS or amniocentesis) |  | 10-20 weeks post intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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preimplantation diagnosis