linjc16/ctgov huggingface dataset:
Biomechanics Based Prediction of Preterm Delivery

Study Overview
=================
Brief Summary
-----------------
Quantitative information on the biomechanical properties of the ecto-cervix in mid-pregnancy will be compared between women with term vs. preterm delivery. We aim to demonstrate that biomechanical data (ASP and CCI) might complement morphological data (CL) to improve prediction of preterm delivery. It is expected that women with preterm delivery will show stronger weakening of cervical tissue. Aspiration (ASP) and cervical CCI (cervical consistency index) measurements are performed at mid-pregnancy: detection at this time point is useful for therapy and biomechanical modifications are already significant so to enable differentiation by biomechanical measurements (ASP and CCI).

Official Title
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Biomechanics Based Prediction of Preterm Delivery

Conditions
-----------------
Preterm Delivery

Intervention / Treatment
-----------------
* Device: Pregnolia System


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All pregnant women presenting at their mid pregnancy consultation (18+0 - 22+0 weeks of pregnancy) are eligible Signed informed consent after being informed is a prerequisite for enrollment. Exclusion Criteria: Communication problems Missing consent Age<18 Active bleeding / Premature Rupture of Membranes (PROM) Active genital infection Known carrier of HIV or Hepatitis B or C Placenta praevia Müllerian anomalies known or suspected non-compliance, drug or alcohol abuse cerclage use of pessary

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pregnancy<br> | Device: Pregnolia System<br>* No intervention is done except for measuring the stiffness of the cervix in pregnant women<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in cervical stiffness in women with/without preterm delivery | The biomechanical measurements and morphological data obtained at mid-pregnancy are compared between women with/without preterm delivery and are expected to significantly differ. The diagnostic power for preterm delivery of aspiration, CCI and the other factors will be determined. | Measurements between 18+0/7 and 22+0/7 weeks of pregnancy and postpartum | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
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Preterm delivery, Diagnostics, Biomechanics
Asthma Partnership for Minority Children

Study Overview
=================
Brief Summary
-----------------
To evaluate the efficacy of a community-based intervention to improve asthma management for parents, children and health care providers.

Detailed Description
-----------------
DESIGN NARRATIVE: Forty-two (42) elementary schools in urban Baltimore and Washington, DC, served as recruitment sites and approximately 300 students with moderate to severe asthma were enrolled. All participants enrolled in the A+ Asthma Program. Primary care practitioners of these students were randomized to a minimal contact program or to the A+ asthma physician partnership. They were offered a menu of educational offerings to improve their knowledge and skills. The primary outcome measure was emergency care use. Secondary measures included physician practices, hospitalization, health care utilization, restricted activities, medication use, school absences and coping skills. The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System (PRS) record.

Conditions
-----------------
Asthma, Lung Diseases

Participation Criteria
=================
Eligibility Criteria
-----------------
No eligibility criteria

Ages Eligible for Study
-----------------
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever

Study Overview
=================
Brief Summary
-----------------
Abstract Background Tick-Borne Relapsing Fever (TBRF) is an acute febrile illness. In Israel, TBRF is caused by Borrelia persica and is transmitted by Ornithodoros tholozani ticks. We examined the safety and efficacy of a post exposure treatment policy to prevent TBRF. Methods In a double blind, placebo controlled trial 93 healthy volunteers with suspected tick exposure (51 with bite signs and 42 contacts) were randomly assigned to receive either Doxycycline (200 mg for the first day and 100mg/d for 4 days) or placebo, approximately 2 days after contact. Blood smears were examined for Borrelia at inclusion and during fever rise. Serology for Lyme disease cross- reactivity and PCR for Borrelia GlpQ gene were also performed. Cases of TBRF were defined as subjects having fever and a positive blood smear.

Official Title
-----------------
Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever

Conditions
-----------------
Relapsing Fever, Tick-Borne, Jarisch Herxheimer Reaction

Intervention / Treatment
-----------------
* Drug: doxycycline treatment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: suspected exposure to tick-borne relapsing fever after returning from field exercise in a tick-borne relapsing fever infected area having a tick bite or staying in field in close proximity to a subject with tick bite sign Exclusion Criteria: known sensitivity to tetracycline or doxycycline febrile illness on recruitment
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: doxycycline treatment|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
Effects Of Oral Prednisolone On Bone Metabolism In Patients With Chronic Obstructive Pulmonary Disease

Study Overview
=================
Brief Summary
-----------------
The aim of this study is to establish associations between blood and urine markers of bone metabolism with histomorphometric changes (changes in the actual bone structure) resulting from short term oral prednisolone treatment in patients with COPD (chronic obstructive pulmonary disease).

Official Title
-----------------
Investigation of the Side Effects of Orally Administered Glucocorticoids. An Open Label Study to Investigate the Effects of Orally Administered Prednisolone on Bone Metabolism in Patients With COPD.

Conditions
-----------------
Chronic Obstructive Pulmonary Disease

Intervention / Treatment
-----------------
* Drug: prednisolone


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Females subjects must be unable to have children. BMI 19 - 29.9 Non-smokers, ex-smokers or current light smokers (<10 cigarettes/day) Exclusion criteria: High blood pressure Other significant disease Use of certain medications (to be decided by the investigator)

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 75 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: prednisolone|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mineral apposition rate Mineralising surface Eroded surface Bone formation rate Osteocalcin levels Serum and urinary deoxypyridinoline |  | All measured with and without 3 weeks dosing with oral prednisolone | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pharmacokinetic measurements Bone structure and micro computer tomography of bone biopsies Biochemical markers of bone formation, bone break down and hormones |  | All measured with and without 3 weeks dosing with oral prednisolone | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
COPD, prednisolone, bone biopsy, tetracycline labelling
Laryngeal View With Videolaryngoscopy

Study Overview
=================
Brief Summary
-----------------
To prevent bronchial aspiration during induction of anaesthesia it has been a common procedure to perform a cricoid pressure, called Sellicks Maneuver, to occlude esophagus, and thereby prevent aspiration. During the last ten years the efficiency of this maneuver has been discussed, since it probably prolong the intubation time and do not significantly reduces the risk of aspiration. The hypothesis is that Sellicks Maneuver prolong the time of intubation and reduces the view of the laryngeal inlet, during intubation with a videolaryngoscopy. The hypothesis is tested by a double-blinded randomized study where patients is intubated twice, with and without Sellicks Maneuver, in a randomized order. The specific cricoid pressure is blinded to the personal performing the intubation.

Official Title
-----------------
Laryngeal View With Intubation by Videolaryngoscopy With and Without Sellicks Maneuver.

Conditions
-----------------
Respiratory Aspiration, Hypoxemia

Intervention / Treatment
-----------------
* Procedure: Cricoid pressure


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: ASA 1-2, BMI < 35, no indication for rapid sequence induction, age > 18, able to give consent. Exclusion Criteria: ASA > 2, BMI > 35, RSI

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Intervention Model: Single Group Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cricoid pressure<br>A cricoid pressure of 30 N is done to occlude esophagus under a rapid sequence induction. | Procedure: Cricoid pressure<br>* The patient is intubated twice, once with a cricoid pressure and once with a sham-pressure, when performing a videolaryngoscopy.<br>* Other names: Profylaxis of bronchial aspiration;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Completed intubation within 120 seconds | The primary outcome measure is the rate of completed and failed intubations. A intubations is failed when the oxygen saturation is less then 95% or the intubation time is longer then 120 seconds. | 120 seconds | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| A description of the laryngeal inlet | The secondary outcome measure is a description of the laryngeal inlet according the the Cormack-Lehan system, and how Sellicks Maneuver alters that view. | 120 seconds | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Videolaryngoscopy, Bronchial Aspiration, Hypoxia
Long Term and Permanent Contraceptive

Study Overview
=================
Brief Summary
-----------------
We will study with the different variables that affect the intention to use long- acting and permanent contraceptive methods among married women in Jordan through a cross sectional study. Self- administered questionnaire will be distributed to aid in data collection.

Detailed Description
-----------------
In this cross-sectional study, self-administered pre-made questionnaires. (https://docs.google.com/forms/d/e/1FAIpQLSdjuuQynIxu0AAmIbKHg0-iyZgTW0m5847JaX0OZrnl7v7v1w/viewform ) will be distributed to married women. (Women of childbearing age). The candidates will be selected according to their age (15-49), marital status (married), and pregnancy status (non-pregnant). The data collected through the questionnaires will then be processed and interpreted in order to understand the variables that affect the use of LACM and permanent contraception methods among Jordanian women.

Official Title
-----------------
Factors Affecting the Use of Long Term and Permanent Contraceptive Methods; Cross Sectional Study.

Conditions
-----------------
Contraceptive Behavior

Intervention / Treatment
-----------------
* Other: Al-Husban University Naser


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: females used or currently using long-term contraception Exclusion Criteria: never users of contraception

Ages Eligible for Study
-----------------
Minimum Age: 15 Years
Maximum Age: 49 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Al-Husban University Naser|filling a questionnaire|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The use of LACM and permanent contraception methods measure by a questionnaire |  | 2 months |
Time Up and go in Hemiplegic Patients

Study Overview
=================
Brief Summary
-----------------
Investing the Timed Up and Go (TUG) Test in Hemiplegic Patients Using 3D Motion Analysis

Detailed Description
-----------------
The timed up and go is a routine quick test assessing motor functional tasks including stand up ,walk 3 m,turn around and sitting down.We will included hemiplegic patients to quantify biomechanic parameters

Official Title
-----------------
Quantification of Biomechanical Parameters of Functional Task Time Up and Go in Hemiplegic Patients

Conditions
-----------------
Difficulty Walking

Intervention / Treatment
-----------------
* Other: Walking test


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients performing 3D gait analysis Male or female adults aged ≥ 18 years, Hemiplegia following unique stroke- Patients with hemiplegia able to stand up alone,walk and turn around alone without assistance. Exclusion Criteria: Patient with a protective measure, Pregnant women, breastfeeding Brain damage bilateral cerebellar syndrome, apraxia and / or severe aphasia, Patient who received botulinum toxin injection in the 3 months prior to inclusion, patients who underwent surgery of the locomotor system in the 6 months prior to inclusion, No affiliation to a social security other pathology, complications with significant impact on the activities of walking.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hemiplegic subjects<br>60 hemiplegic outpatients walking test | Other: Walking test<br> <br> * Other names: The TUG test included stand up ,walk,turn around ,sit down;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variability of the center of mass | subjects will perform the TUG test with 3D walk analysis equipment | 1 hour | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
hemiplegic, time up and go test, motion analysis, center of mass
Empirical Antibiotic and Outcome in Community-onset Bacteremia

Study Overview
=================
Brief Summary
-----------------
Empirical antibiotic and outcome in Community-onset Bacteremia Caused by third generation cephalosporin resistant Enterobacteriaceae

Detailed Description
-----------------
Prospective cohort study is conducted for monitoring outcomes and risk factors among community-onset bacteremia caused by third generation cephalosporin resistant enterobacteriaceae. Primary endpoint is mortality rate among those who received initially inappropriate antimicrobial which switch to appropriate antimicrobial later when culture and antimicrobial susceptibility test reported among community-onset bacteremia caused by third generation cephalosporin resistant enterobacteriaceae.

Official Title
-----------------
Empirical Antibiotic and Outcome in Community-onset Bacteremia Caused by Third Generation Cephalosporin Resistant Enterobacteriaceae

Conditions
-----------------
Bacteremia

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patient with Community-onset Bacteremia Caused by third generation cephalosporin resistant Enterobacteriaceae. Age > 18 years Exclusion Criteria: Pregnancy Polymicrobial infection

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Community onset 3rd generation cephalosporin resistant entero<br>Patient with Community onset third generation cephalosporin resistant enterobacteriaceae bacteremia who received inappropriate Antibiotic | |
| Nosocomial onset 3rd generation cephalosporin resistant ente<br>Patient with Nosocomial onset third generation cephalosporin resistant enterobacteriaceae bacteremia who received appropriate Antibiotic | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Mortality rate among community-onset bacteremia caused by third generation cephalosporin resistant enterobacteriaceae |  | January 2018 - march 2019 |
Investigation on the Role of Corticosteroids and Beta-Agonists on Cytokine Production in COPD Patients

Study Overview
=================
Brief Summary
-----------------
Research on the synergistic effect of corticosteroids and beta-agonists on the cytokine production in COPD patients. Blood will be obtained from healthy volunteers and COPD patients and blood monocytes will be stimulated to produce cytokines with or without the prementioned drugs.

Official Title
-----------------
Experimental Study on the Role of Corticosteroids and Beta-Agonists on Cytokine Production in COPD Patients

Conditions
-----------------
COPD

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: clinical COPD smoking age > 40 years Exclusion Criteria: age < 40 years use of antibiotics, corticosteroids or beta-agonists

Ages Eligible for Study
-----------------
Minimum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
COPD, cytokines, corticosteroids, beta agonists, synergistic effect
Gene Mutations in Secondary Pulmonary Hypertension

Study Overview
=================
Brief Summary
-----------------
As a pulmonary hypertension center, we have created a database that prospectively tracks patients with different forms of secondary pulmonary hypertension. Records include genetic analysis, and clinical and hemodynamic profiles.

Conditions
-----------------
Chronic Thromboembolic Pulmonary Hypertension

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Diagnosis of CTEPH and patient consent Exclusion Criteria: No patient consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |