Establishing the Central and Peripheral Fatigue Indexes and VR Based Anti-fatigue Training Paradigm for Individuals With Parkinson Disease

Study Overview
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Brief Summary
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Fatigue is one of the most common symptoms in individuals with Parkinson's Disease (PD). Past researches indicated that more than half of the individuals with PD demonstrated fatigue symptom. The severity of fatigue was also correlated to the quality of life in individuals with PD. Finding the contributions of the central and the peripheral factors to fatigue, building reliable fatigue indexes, and developing an effective training program for individuals with PD are very important. The purpose of this project is to develop non-invasive method to monitor central and peripheral fatigue, to establish Virtual Reality(VR) anti-fatigue ergo cycling training paradigm, and to evaluate the long term training effect in individuals with PD.

Conditions
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Parkinson's Disease (PD)

Intervention / Treatment
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* Procedure: Virtual Reality anti-fatigue ergo cycling training (Self-made)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of Parkinson disease Hoehn and Yahr ≦3 Exclusion Criteria: Musculoskeletal injuries Osteoporosis Diabetes Any peripheral or central nervous system injury or disease patients

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Stage 1: Health group<br>To establish non-invasive fatigue monitoring method via testing healthy individuals. | |
| Experimental: Stage 2: PD group<br>To find the optimal feedback variables for anti-fatigue training on individuals with PD. | Procedure: Virtual Reality anti-fatigue ergo cycling training (Self-made)<br>* To establish a Virtual Reality systems to reduce fatigue of cycling training for PD subjects.<br>|
| Experimental: Stage 2: Health group<br>Stage 2 controlled group | Procedure: Virtual Reality anti-fatigue ergo cycling training (Self-made)<br>* To establish a Virtual Reality systems to reduce fatigue of cycling training for PD subjects.<br>|
| Experimental: Stage 3: PD group<br>To evaluate the effect of four weeks of VR anti-fatigue ergo cycling training on various fatigue components and functional abilities in individuals with PD. | Procedure: Virtual Reality anti-fatigue ergo cycling training (Self-made)<br>* To establish a Virtual Reality systems to reduce fatigue of cycling training for PD subjects.<br>|
| No Intervention: Stage 3: PD controlled group<br>Stage 3 controlled group | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle twitch force | Measure of changes in muscle twitch force by interpolation twitch technique. | baseline, 1 week | 
| Muscle voluntary activity level | Measure of changes in muscle voluntary activity level by interpolation twitch technique. | Baseline,1 week | 
| Heart rate/Heart rate variability | Measure of changes in Heart rate/Heart rate variability. | Baseline,1 week | 
| Borg's rate of perceived exertion | Measure of changes in Borg's rate of perceived exertion. | Baseline,1 week | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Fatigue, electromyography (EMG), central fatigue, cycling training