linjc16/ctgov huggingface dataset:
Induction of Neutrophilic Traps ( NETs ) by the Environment and Infectious Inflammatory Lung Cystic Fibrosis

Study Overview
=================
Brief Summary
-----------------
The study is defined in 3 stages of in vitro assays : Phase 1 : Secretion of NETs in response to lung disease and their secretion of factors. This is a transversal study in which we compare : Producing NETs (DNA and proteases ) by neutrophils purified from sputum and blood of patients Producing NETs (DNA and proteases ) by purified neutrophils in the blood of patients and blood of control subjects Phase 2: Mechanisms of activation of NETs secretory pathways . This phase will identify receptors (TLR ) involved in the secretion of NETs and analyze the involvement of dependent transduction pathways calcium and PKC . It will be performed on control blood neutrophils. Phase 3: Analysis of cell death ( NETose ) This is a transversal study that will analyze : the mode of cell death of neutrophils purified blood and sputum of patients and control blood neutrophils by flow cytometry and transmission electron microscopy .

Official Title
-----------------
Secretion Induction of Neutrophil Extracellular Traps (NETs)in Inflammatory and Infectious Environment of Mucoviscidose

Conditions
-----------------
Cystic Fibrosis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients : Men or women over 18 Patients with mucoviscidose in stable condition, i.e. not having presented an acute push of bronchopulmonary attack requiring a antibiothérapie or a hospitalization for treatment of its disease during the 2 previous weeks Signed consent Volunteers : Men or women over 18 Without respiratory antecedent nor known respiratory pathology Signed consent Exclusion Criteria: Patients : In exclusion period of an other study Volunteers : In exclusion period of an other study Antibiotic treatment and/or anti-inflammatory drug (AINS or corticoids) in the 2 weeks before inclusion in the study

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| T<br>Control | |
| A<br>Adult with cystic fibrosis | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the DNA concentration secreted into the extracellular environment neutrophil activated |  | 1 hour |
Motor Learning of a Planning Task in Stroke Patients: the Maze Paradigm Measured Through Time and Error as Variables

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to investigate the process of acquiring a motor skill subject in post-stroke, comparing them with healthy subjects.

Detailed Description
-----------------
20 post-stroke patients were comprised to the experimental group (EG) and 20 health subjects were included to the control group (CG. Inclusion criteria: chronic stroke, single stroke event, lesion in anterior circulation, right handed subjects, MEEM over 23 points. The task consisted in a maze paradigm, made by pencil and paper, with the non affected side for EG and left upper extremity for CG. The instruction was given to the subjects to complete the task as fast as possible. The study consisted in three phases: acquisition (AQ)with 30 trials, transfer (TR, short retention (R1)and long term retention (R2 both with 5 trials.

Official Title
-----------------
Motor Learning of a Planning Task in Stroke Patients

Conditions
-----------------
Stroke

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age between 40 and 65 Injury in territory of movement earlier, as shown by examination of image and finding medical neurologist Time of injury over 6 months Single vascular event Right handed, by applying the Inventory of Dominance Side of Edinburgh Mini mental with scores over 23 points Exclusion Criteria: Aphasia of understanding Instability clinic Other neurological diseases associated (Parkinson's disease, dementias, Alzheimer)

Ages Eligible for Study
-----------------
Minimum Age: 45 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| TIME | time (in seconds) | 3 times in a week (acquisition, transfer an retention phase) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| error | number of mistakes made by the subjects | 3 times in a week (acquisition, transfer an retention phase) |
Evaluation of the Analgesic Effect of Music Therapy in Critically Ill Patients During Potentially Painful Nursing Procedures: a Pilot Study

Study Overview
=================
Brief Summary
-----------------
Pain is a common problem encountered in about 60 % of critically ill patients who can communicate. Its occurrence can be related to several causes, mainly dominated by invasive procedures. Pain management is typically based on a combination of prevention, evaluation, and therapeutic agents. However, it appears important to develop adjuvant approaches. Music therapy is one of them and that has been evaluated in various medical conditions. The aim of our study is to evaluate the analgesic effect of music therapy in critically ill patients during potentially painful nursing procedures.

Conditions
-----------------
Pain

Intervention / Treatment
-----------------
* Other: music therapy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All adult patients (age≥18 years) hospitalized in Intensive Care Unit Requiring mechanical ventilation Who cannot communicate With a Richmond Agitation Sedation Scale (RASS) score [-3; +4] Exclusion Criteria: Age < 18 years Receiving neuromuscular blockade

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: music therapy<br>Music therapy | Other: music therapy<br>* Music therapy will be delivered through headphones during nursing procedures (toilet and/or surgical dressings): from initiation up to 30 minutes after the end of procedure.<br>|
| No Intervention: control arm<br>No music | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| proportion of pain exposure during nursing procedures | total length of pain exposure to a BPS score over or equal to 5 divided by total length of nursing procedure | 150 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| proportion of maximal pain exposure during nursing procedures | Total length of exposure to the maximal BPS score (over or equal to 5) among total length of nursing procedure | 150 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
critically ill, mechanical ventilation, pain, nursing, music
Imaging Parameters to Predict Future Vertebral Fracture in Osteoporosis

Study Overview
=================
Brief Summary
-----------------
After vertebroplasty, many patients will suffer from 2nd fracture in the vertebral column. With analyzing of the images done right after the 1st vertebroplasty, we can define the parameters from different imaging and they can be predictors of the future fracture.

Detailed Description
-----------------
Vertebroplasty is considered one of the alternatives for the treating of spine compression fracture associated with pain especially for those patients with osteoporosis. However, after vertebroplasty, the compliance of the bone becomes stronger than the adjacent vertebrae that is not treated. So there is always a consideration of future fracture of the adjacent vertebral bodies after vertebroplasty done on certain body. In this study, we try to follow the patients (5 years) to see if the adjacent vertebral bodies are prone to have fracture than the others away from the site of vertebroplasty.Then we try to find out the image biomarkers to predict the future fracture in the vertebral bodies. The should be done with CT scan raw data, analysis with different algorithms. Inclusion criteria; patients with osteoporosis and receiving vertebroplasty and with secondary fracture occurring in other spine exclusion criteria: No second vertebral body fracture occurred. Primary measurement: the time and location of the 2nd fracture secondary measurement: the imaging biomarkers from CT scan.

Official Title
-----------------
to Compare the Efficacy of Parameters From Different Imaging Modality in Predicting the Risk of Future Vertebral Compression Fracture in Osteoporotic Patients.

Conditions
-----------------
Osteoporosis, Fracture

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All the patients received vertebroplasty treatment between 2005.01-2011.12 with 2nd fracture in the vertebral column. Exclusion Criteria: No image available

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| fracture | 2nd fracture within 5 years | 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
fracture, vertebral column, osteoporosis, predictor, vertebroplasty
rTMS for Auditory Hallucinations Guided by Magnetoencephalography

Study Overview
=================
Brief Summary
-----------------
Repetitive transcranial magnetic stimulation (rTMS) can increase or decrease cortical excitability in patients with psychosis (such as schizophrenia). Here, we conducted an open clinical trial on 60 schizophrenics with auditory hallucinations. We searched for targets through magnetoencephalography and then intervened to prove that rTMS guided by magnetoencephalography is effective for auditory hallucinations.

Detailed Description
-----------------
Before receiving rTMS treatment, patients should do multiple magnetoencephalograms (such as 3 times) to find the target. The patient opened his eyes and rested quietly while receiving 1Hz low frequency rTMS for 23 minutes. The 8-shaped coil corresponds to the result of magnetoencephalogram positioning by the electrode position. A total of one course of treatment (15-20 days) was intervened, and five follow-up visits were made respectively on the 7th, 14th, 30th, 60th and 90th days after the intervention.

Official Title
-----------------
rTMS for Auditory Hallucinations Guided by Magnetoencephalography

Conditions
-----------------
Schizophrenia

Intervention / Treatment
-----------------
* Device: rTMS and MEG for auditory hallucinations via single arm


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Schizophrenia with auditory hallucinations was diagnosed by DSM-IV, AHRS >12, Take sufficient antipsychotics for at least 1 month. Exclusion Criteria: current pregnancy, major medical illness affecting the central nervous system, significant neurologic disorders, intake of drugs including supplements like essential fatty acids that influence prostaglandins or niacin skin flush flash pathway metabolism, a history of suicide risk, or alcohol or drug abuse.

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: schizophrenia patients with auditory hallucinations<br>For schizophrenia patients with auditory hallucinations, rTMS+MEG for implementation intervention | Device: rTMS and MEG for auditory hallucinations via single arm<br>* a 4 weeks, weekly 230 minutes, 1Hz, 100%RMT-rTMS protocol<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Reduction rate of AHRS scale | Reduction rate of AHRS scale (the minimum is 0, maximum value is 47, and higher scores mean a worse outcome) | One month |
Vitamin B12 Supplementation Study

Study Overview
=================
Brief Summary
-----------------
We hope to learn the clinical and functional signs of sub-clinical vitamin B12 deficiency and its response to supplementation in non-anemic, non-pregnant, and non-lactating women in Rural Mexico. Vitamin B12 is important in hematopoiesis, neuro-cognitive functions and genetic integrity. However vitamin B12 is only found in animal source foods therefore a large segment of the population in developing countries and those practicing vegetarianism are at risk of deficiency of the vitamin. This information will help decide weather supplementation with vitamin B12 is necessary in such populations for public health reasons.

Official Title
-----------------
Assessment of Functional Vitamin B12 Deficiency in Mexican Women

Conditions
-----------------
Vitamin B12 Deficiency

Intervention / Treatment
-----------------
* Dietary Supplement: Vitamin B12
* Dietary Supplement: placebo


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Women age 20-59, apparently healthy, no severe B12 deficiency Exclusion Criteria: pregnancy, lactation, anemia and disease states

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 59 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: placebo<br>Receive placebo (sugar pill) during the intervention. Received a 1000 mg vitamin B12 injection at the end of the study. | Dietary Supplement: placebo<br>* placebo given as a daily supplement 1000 mg injection of vitamin B12 given at the end of the study<br>* Other names: sugar pill;|
| Active Comparator: Vitamin B12<br>Received 500 micrograms vitamin B12 per day during the study Received a 1000 mg vitamin B12 injection at the start of the study | Dietary Supplement: Vitamin B12<br>* 500 microgram daily supplement of vitamin B12 1000 mg injection vitamin B12 given at the start of the study<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| response to B12 supplementation in serum B12, Methylmalonic acid, homocystein, and holotranscobalamin concentrations |  | 0 and 3 mos | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| DNA methylation change, and hematological response to B12 supplementation |  | 0 and 3 mos | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
B12 deficiency, methylmalonic acid, homocystein, vitamin B12 supplementation intervention
Implications of Ethics Determinant on Dentistry and Pharmacy Research

Study Overview
=================
Brief Summary
-----------------
The ethical review of dental and pharmacy research protocols has its own challenges facing the institutional ethical committees. Seemingly low risk procedure might pose controversies among committees' members. The aim of this article is to describe some of the ethical concerns, particular to dental and pharmacy research that an ethics committee could face while reviewing dental research.

Detailed Description
-----------------
The investigators have read all protocols submitted to the MIU IRB and reviewed all meetings' minutes to outline the ethical concerns that warranted discussions in the meetings, and how the committee came to a resolution for those concerns.

Official Title
-----------------
Implications of Ethics Determinant on Dentistry and Pharmacy Research: A Study of IRB Perspective

Conditions
-----------------
Review, Research Peer

Intervention / Treatment
-----------------
* Other: Review


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: all protocols submitted to IRB Exclusion Criteria: -
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: Review|Reviewing all protocols|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Ethical concerns | Frequencies and percentages of ethical concerns | 1 month | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Dental Ethics, Pharmacy Ethics, Institutional Ethics Committees
Harmonic vs HF Knife in Patients Requiring Abdominal Surgery

Study Overview
=================
Brief Summary
-----------------
Prospective, non-randomized, controlled study to investigate the clinical outcome of surgery using the Harmonic knife vs the HF knife in patients requiring abdominoplastic surgery or body lift (Lockwood)

Detailed Description
-----------------
Aim of the study is to measure amount of seroma in each interventional arm.

Official Title
-----------------
Clinical Outcome of the Seroma Amount Using the Harmonic vs the HF Knife for Surgery According to Lockwood and Abdominoplastic Surgery: A Prospective Controlled Study

Conditions
-----------------
ABDOMINAL SUBCUTANEOUS FAT

Intervention / Treatment
-----------------
* Procedure: abdominal plastic surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years willing to give consent indication for abdominoplastic surgery no contraindication for general anaesthesia Exclusion Criteria: Smoking more than 10 p/day Diabetes mellitus I or II known neoplasms not willing or able to conform with study requirements

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Harmonic knife<br>surgery using the Harmonic knife | Procedure: abdominal plastic surgery<br>* Surgery for ABDOMINAL SUBCUTANEOUS FAT<br>|
| Active Comparator: HF knife<br> | Procedure: abdominal plastic surgery<br>* Surgery for ABDOMINAL SUBCUTANEOUS FAT<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| amount of seroma |  | first post operative day until hospital discharge |
Effects of Chronic Smoking on Circulating Endothelial and Platelet-derived Microparticle

Study Overview
=================
Brief Summary
-----------------
The investigators hypothesized that circulating EMP is a useful surrogate marker of early stage of endothelial damage. To determine the effects of chronic smoking on circulating EMP, from healthy volunteers who have habit of chronic smoking, peripheral blood is drawn at the time of flow-mediated dilatation (FMD) examination. Spot urine is also collected. Circulating EMPs are counted using flow-cytometry. After 2-week smoking cessation, the measurements were repeated.

Official Title
-----------------
Effects of Chronic Smoking on Circulating Endothelial and Platelet-derived Microparticle

Conditions
-----------------
Atherosclerosis

Intervention / Treatment
-----------------
* Behavioral: smoking cessation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy individuals who have no coronary risk factors Exclusion Criteria: hypertension dyslipidemia chronic kidney disease liver dysfunction obesity (BMI>25.0) cerebrovascular disease other severe systemic diseases (cancer, inflammatory diseases, etc)

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Screening
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: smoker<br>Individuals who have a habit of chronic smoking without any coronary risk factors | Behavioral: smoking cessation<br>* After baseline examination, the group is asked to quit smoking for 2 weeks.<br>|
| No Intervention: non-smoker<br>the age-matched healthy volunteers | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The number of circulating EMP |  | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| FMD |  | 2 weeks |