Acute Coronary Syndrome in Diabetic Patients

Study Overview
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Brief Summary
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This study aims to compare the clinical profile and outcomes of acute coronary syndrome patients with diabetes and without diabetes.

Detailed Description
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Adult patients (≥ 18 years of age) with acute coronary syndrome which are diagnosed under International Classification of Disease (ICD-10) coding of I24.9 were included in this study. The inclusion criteria are patients with primary diagnosis of I24.9 and with a complete record of prior medical and treatment history, electrocardiographic findings, cardiac marker results and outcomes. Participants were grouped into 2 groups - diabetic and non-diabetic based on history of diabetes prior to ACS. Diagnosis of ACS was made based on clinical, electrocardiographic and cardiac marker findings found in the medical record. Data such as age, sex, ethnic, education, prior medical and treatment history, electrocardiographic and cardiac enzyme results as well as outcomes were collected from the patients' medical records. Outcomes of interest were defined as either concomitant heart failure, acute lung edema, malignant arrhythmia, mortality or combinations of them as diagnosed in the medical records. Heart failure is defined based on echocardiographic findings from the medical records. Acute Lung Edema is defined based on medical records or reported clinical findings of lung edema - rhonchi reported in 1/3 of the lungs with oxygen saturation <90%. Whereas malignant arrhythmia is defined as the presence of ventricular tachycardia (VT) or ventricular fibrillation (VF).

Official Title
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Comparing Clinical Profile and Outcomes of Acute Coronary Syndrome in Diabetic and Non-Diabetic Patients

Conditions
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Acute Coronary Syndrome, Diabetes Mellitus, Heart Failure, Acute Pulmonary Edema, Cardiac Arrythmias

Intervention / Treatment
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* Other: No intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Clinical diagnosis of Acute Coronary Syndrome Presence of detail on diabetes history Exclusion Criteria: Unavailability of electrocardiographic findings, cardiac marker results Incomplete records of prior medical and treatment history
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Diabetic<br>History of diabetes prior to Acute Coronary Syndrome | Other: No intervention<br>* Routine care<br>|
| Non-diabetic<br>No documented history of diabetes prior to Acute Coronary Syndrome | Other: No intervention<br>* Routine care<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Heart Failure | Based on echocardiographic findings from the medical records | Through study completion, an average of 1 year | 
| Malignant Arrhythmia | Presence of ventricular tachycardia (VT) or ventricular fibrillation (VF) | Through study completion, an average of 1 year | 
| Acute Lung Edema | Based on medical records or reported clinical findings of lung edema - rhonchi reported in 1/3 of the lungs with oxygen saturation <90%. | Through study completion, an average of 1 year | 
| Cardiogenic Shock | Clinical Diagnosis of Cardiogenic Shock reported in medical records | Through study completion, an average of 1 year | 
| Recurrent Myocardial Infarction | Clinical Diagnosis of Recurrent Myocardial Infarction reported in medical records | Through study completion, an average of 1 year | 
| Mortality | Patient death reported in medical records | Through study completion, an average of 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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malignant arrhythmia, acute coronary syndrome, heart failure, acute pulmonary edema, diabetes