Study of the Impact of Welding Fumes on the Arterial System : RISCAS Study

Study Overview
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Brief Summary
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Metals and oxydes are found in welding fumes and are thought to participate in increasing cardiovascular risk in exposed workers. Investigators aimed to evaluate the impact of this occupational exposure on cardiovascular system in a highly exposed population, ship repairing welders and to compare this population to paired controls.

Detailed Description
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In an exposed-non-exposed study, investigators will include 30 welders and 30 airport runway agents for control. As part of cardiovascular independent risk factors, microvascular endothelial function will be evaluated directly by laser Doppler flowmetry. Blood samples will be also collected and circulating markers of endothelial function (VW factor, E-selectin, VCAM, ICAM, circulating DNA), inflammation (CRP, IL-1β, IL-8, TNFα, IL-10), platelet activation (procoagulant microparticles, thrombin generation, fibin monomer) will be measured. A complete clinical and functional cardiovascular status will be documented in every participant.

Official Title
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Study of the Impact of Welding Fumes on the Arterial System : RISCAS Study

Conditions
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Effects of Welding Fumes Components

Intervention / Treatment
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* Diagnostic Test: Laser doppler, blood tests, and holter ECG


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or Female ≥ 18 years Employee performing welding or airport operations free, informed and written consent Being affiliated to a social security system Exclusion Criteria: Taking cardiovascular medications which modify endothelial function and / or coagulation (antiplatelet, antihypertensive, cardiotropic). People with a history of ischemic cardiovascular disease, thrombotic disease, chronic inflammatory disease Pregnant women People with health status would be likely, in the baseline state, to have parameters studied in the study disrupted.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: welder/airport agent<br>No drug and no placebo were used in this study. | Diagnostic Test: Laser doppler, blood tests, and holter ECG<br>* Diagnostic tests : laser doppler blood tests Holter ECG. No drug and no placebo were used in this arm.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vascular reactivity | Assessement of microvascular reactivity by laser Doppler flowmetry associated to iontophoretic administration of ACh and SNP | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Coagulation activation | Assessment of markers of blood coagulation | 1 day | 
| vascular inflammation | Assessment of factors of inflammation | 1 day | 
| Impregnation of metals activation | Assessment of impregnation factor | 1 day | 
| Oxidative stress activation | Assessment of markers of oxidative stress | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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welder, airport agent, Welding fumes