Preoperative Anxiety at Oocyte Retrieval

Study Overview
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Brief Summary
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This study evaluated the effects of preoperative anxiety and dosage of anesthesia on IVF success. Half of participants according to the recorded Beck's Anxiety Inventory (BAI) score: a low-anxiety group, while the other half high-anxiety group.

Detailed Description
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Anxiety is common among women hospitalized for oocyte retrieval. Infertility is usually accompanied by psychological and behavioral changes and can result in preoperative anxiety. Sometimes, preoperative anxiety can be serious. Furthermore, in the absence of premedication for oocyte retrieval, severe degrees of anxiety may occur. Anxiety effects the total consumption of analgesic and anesthetic drugs intraoperatively and has a negative impact on recovery from anesthesia. In addition, the negative effect of anesthetic agents used on fertilization and embryo quality during in vitro fertilization (IVF) has been discussed. However, the impact of any of them on fertilization and embryo quality has not been clearly determined to date. Studies have reported different results regarding the negative effects of anesthetic agents on embryo development and fertilization.

Official Title
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The Effect of Preoperative Anxiety With Depth of Anesthesia During Oocyte Retrieval on IVF Success

Conditions
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Infertility, Female, Anesthesia Awareness, Anxiety State

Intervention / Treatment
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* Device: Monitoring brain function
* Drug: propofol


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: oocyte retrieval under sedation 25 and 43 years of age American Society of Anesthesiologists physical status I-II Exclusion Criteria: history of psychiatric illness secondary infertility can be surgically corrected not able to communicate well in the native language those women who necessitated general anesthesia

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 43 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Monitoring brain function-low-anxiety<br>Anxiety has determined a cutoff score of 17. Patients were divided into two groups according to the recorded BAI score: a low-anxiety group and a high-anxiety group.The monitoring brain function values were recorded at baseline, 5 minutes, 15 minutes, and after anesthesia. Propofol was performed by ventilation with face mask. Monitoring brain function was keep value between 40 and 60. | Device: Monitoring brain function<br> <br> Drug: propofol<br> <br> * Other names: propofol %1;|
| Active Comparator: monitoring brain function-high-anxiety<br>Anxiety has determined a cutoff score of 17. Patients were divided into two groups according to the recorded BAI score: a low-anxiety group and a high-anxiety group.The monitoring brain function values were recorded at baseline, 5 minutes, 15 minutes, and after anesthesia. Propofol was performed by ventilation with face mask. Monitoring brain function was keep value between 40 and 60. | Device: Monitoring brain function<br> <br> Drug: propofol<br> <br> * Other names: propofol %1;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in perioperative Monitoring brain function were measured | Monitoring brain function was assessed Change from baseline at preoperatively, intraoperative 5th and 15th minutes and after anesthesia | Preoperative, intraoperative and postoperative first minute | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pregnancy rate | pregnancy rate | 10 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Anxiety, Oocyte retrieval, Monitoring of brain function