Effect of Sonication on Periprosthetic Joint Infection Treatment Strategy.

Study Overview
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Brief Summary
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It is not known in the literature how much sonication affects the patient's treatment. Another important issue is that the place of this method in diagnosis is not clear. The aim of this study is to contribute to the literature on this issue and to determine the sensitivity and specificity of sonication prospectively using the new definition and effect of sonication on the treatment strategy in terms of infection in patients with PJI.

Detailed Description
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Total knee and hip arthroplasties are successful surgical procedures that are widely applied all over the world and provide high patient satisfaction and increased quality of life. Periprosthetic joint infection (PJI), is a serious complication that negatively affects the targeted result, decreases patient satisfaction, and increases morbidity and mortality after total joint replacement. Another important issue, the previous infection is the most important reason for the failure of surgery in revision arthroplasty. It is known that the success of PJI treatment seriously can be affected by the type of microorganism and antibiotic sensitivity. Therefore, microbiological examination methods are always of interest, and one of them is the sonication method.

Official Title
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Effect of Sonication on Periprosthetic Joint Infection Treatment Strategy.

Conditions
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Prosthesis-Related Infections, Hip Prosthesis Infection, Joint Infection, Biofilm

Intervention / Treatment
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* Diagnostic Test: Sonication method


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All patients scheduled for revision arthroplasty (aseptic revision, septic revision, instability, and periprosthetic fracture) Exclusion Criteria: who do not accept to participate in research insufficient data for new definition criteria acute periprosthetic infections patients with systemic inflammatory disease
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Sonication method<br>The treatment strategies of all patients will be based on the cultural results to be made by the sonication method. | Diagnostic Test: Sonication method<br>* Sonication dislodges adherent bacteria from explanted prosthetics by ultrasound and may improve the diagnosis of periprosthetic joint infection.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensitivity | To determine how many patients diagnosed with periprosthetic joint infection can be detected by sonication method. | 14 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The change in antibiotic treatment. | In how many patients the sonication method will cause a change in treatment. | 14 days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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total knee arthroplasty, complication, total hip arthroplasty, periprosthetic infection, revision arthroplasty, sonication, biofilm