PTSD, AUD, and Interpersonal Conflict: Within-person Associations

Study Overview
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Brief Summary
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The present study seeks to increase understanding of Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD) among veterans, an important public health concern. We will study the effects of regulatory deficits and sleep disturbance on the dynamic course of PTSD and AUD. The study will investigate whether a short, computerized training in the laboratory will alter maladaptive response biases and reduce associations between sleep disturbance, affect and behavioral dysregulation, AUD symptoms, and PTSD symptoms in the real world.

Official Title
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PTSD, AUD, and Interpersonal Conflict: Within-person Associations

Conditions
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Stress Disorders, Post-Traumatic, Alcoholism

Intervention / Treatment
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* Behavioral: Alcohol CBM
* Behavioral: PTSD CBM
* Behavioral: Alcohol Sham
* Behavioral: PTSD Sham


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: OIF/OEF/OND veterans At risk for PTSD (i.e., PCL-5 ≥33) and/or AUD (i.e., AUDIT ≥ 7 (women) ≥ 8 (men)) Exclusion Criteria: Psychosis or severe Alcohol Use Disorder that contraindicates participation (based on interview) Active suicidal or homicidal ideation that contraindicates participation (based on interview) [exclusion criteria removed 6/2022] - Severe risk for sleep apnea (a positive score in three categories of the Berlin Questionnaire), or reported treatment for sleep apnea

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Alcohol Cognitive Bias Modification (CBM) + PTSD CBM<br> | Behavioral: Alcohol CBM<br>* Trains approach or avoidance responses to alcohol cues.<br>Behavioral: PTSD CBM<br>* Trains approach or avoidance responses to trauma cues.<br>|
| Experimental: Alcohol CBM + PTSD Sham<br> | Behavioral: Alcohol CBM<br>* Trains approach or avoidance responses to alcohol cues.<br>Behavioral: PTSD Sham<br>* Will not train approach or avoidance responses.<br>|
| Experimental: Alcohol Sham + PTSD CBM<br> | Behavioral: PTSD CBM<br>* Trains approach or avoidance responses to trauma cues.<br>Behavioral: Alcohol Sham<br>* Will not train approach or avoidance responses.<br>|
| Sham Comparator: Alcohol Sham + PTSD Sham<br> | Behavioral: Alcohol Sham<br>* Will not train approach or avoidance responses.<br>Behavioral: PTSD Sham<br>* Will not train approach or avoidance responses.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of Alcohol Use Disorder Symptoms | These are experience sampling items derived from Diagnostic and Statistical Manual of Mental Disorders (DSM-5). | 2 years | 
| Rate of PTSD Symptoms | These are experience sampling items derived from the PTSD Checklist from DSM-5 (PCL-5). | 2 years |