linjc16/ctgov huggingface dataset:
Anesthetic Efficacy Of 4% ArtpharmaDent Versus 2% Mepecaine-L in Extraction of Lower First Primary Molars

Study Overview
=================
Brief Summary
-----------------
parallel technique will be done where the investigator (will be blinded) will give one type on anesthesia then performing the extraction and evaluating the intraoperative pain ,the same procedure will be done for the other type of anesthesia.

Official Title
-----------------
Anesthetic Efficacy Of 4% ArtpharmaDent Versus 2% Mepecaine-L for Infilteration Anesthesia in Extraction of Badly Decayed Lower First Primary Molars: Pilot Study

Conditions
-----------------
Badly Decayed Lower First Primary Molars in Children

Intervention / Treatment
-----------------
* Drug: articaine
* Drug: Mepivacaine 2% Injection


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children aged 6-8 years. Medically fit (ASA I, II). Mentally capable of communication. Having a mandibular first primary molar tooth that require Extraction. Child must give assent prior to participation, as well as parental informed written consent. Body weight >20 kg. it should be the first dental treatment to the child Exclusion Criteria: Medically and mentally compromised children. Children without a history of prolonged bleeding, platelet disorders, hypersensitivity, History of significant behavior management problems. Patients having active sites of pathosis in the area of injection. Patients who had taken analgesics or antibiotics in the 12-hrs preceding the injection. Patients allergic to Articaine and/or Mepivacaine and/or sulfur

Ages Eligible for Study
-----------------
Minimum Age: 6 Years
Maximum Age: 8 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: 2% Mepecaine-L<br>infiltration injection of 2% Mepivacaine | Drug: Mepivacaine 2% Injection<br>* infiltration injection of 2% Mepecaine-L<br>* Other names: 2% Mepecaine-L;|
| Experimental: 4% Artpharmadent<br>infiltration injection of 4% Articaine | Drug: articaine<br>* infiltration injection of 4%artpharmadent<br>* Other names: Artpharmadent;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Intra-Operative Pain during Extraction | intraoperative pain will be measured using wong baker pain scale,The scale shows a series of faces ranging from a happy face at 0, or no hurt, to a crying face at 10, which represents hurts like the worst pain imaginable. Based on the faces and written descriptions, the patient chooses the face that best describes their level of pain Face | Immediatly after etxraction |
PRF Versus Advanced PRF in Sinus Augmentation

Study Overview
=================
Brief Summary
-----------------
In the present study the main hypothesis , Advanced PRF will improve the bone quality and quantity in sinus augmentation

Official Title
-----------------
Platelet Rich Fibrin Versus Advanced Platelet Rich Fibrin as Bone Graft Material in Sinus Augmentation (Randomized Controlled Clinical Trial)

Conditions
-----------------
Maxillary Sinus

Intervention / Treatment
-----------------
* Biological: Advanced PRF
* Biological: Control


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: The Patients with missing posterior maxillary teeth with insufficient available bone for implant placement indicating the need for maxillary sinus floor augmentation before implantation. 2. The Patients should be free from any systemic disease that may affect normal healing of bone, and predictable outcome. 3. The Patients should be free from any sinus disease that might affect the health and integrity of the sinus lining. 4. Assign an informed consent to be involved in the study. Exclusion Criteria: Patients with any systemic disease that may affect normal healing. 2. Patients with any sinus disease. -
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Study arm<br>Patients will undergo sinus augmentation with advanced PRF | Biological: Advanced PRF<br>* Advanced PRF will be placed for patients undergoing sinus augmentation<br>|
| Placebo Comparator: Controlled arm<br>Patients will undergo sinus augmentation with PRF | Biological: Control<br>* PRF will be placed for patients undergoing sinus augmentation<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone quality | Histological analysis for core biopsies Available bone quality will be evaluated by measuring the Total Bone Volume (TBV) | Six months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone quantity | • Linear height measurements changes of the bone will be evaluated via panoramic X-rays | Six months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
PRF, Advanced PRF, Sinus augmentation
Protein Before Night Sleep to Improve Recovery and Performance in Runners

Study Overview
=================
Brief Summary
-----------------
32 runners will be randomized into two groups. The duration of the intervention is one week including a strenuous endurance training program. Group 1 receive a protein beverage before each night sleep and Group 2 receive an isocaloric carbohydrate beverage. Performance test before and after the intervention and blood sampling before and during the intervention to check for markers for muscle damage.

Official Title
-----------------
Ingestion of Protein Before Each Night Sleep to Improve Recovery and Performance in Runners

Conditions
-----------------
Healthy

Intervention / Treatment
-----------------
* Dietary Supplement: Sport beverages Protein
* Dietary Supplement: Sport beverages Carbohydrate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: VO2max >55 ml O2/kg/min - Exclusion Criteria:women, smokers -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Male

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sport beverages Protein<br>Intervention group ingesting PROTEIN | Dietary Supplement: Sport beverages Protein<br>* Beverage ingested before each night sleep during the intervention<br>|
| Active Comparator: Sports beverage Carbohydrate<br>Placebo group ingesting carbohydrate | Dietary Supplement: Sport beverages Carbohydrate<br>* Beverage ingested before each night sleep during the intervention<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Performance | 5 km time trial | 8 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle damage | creatine kinase | 8 days |
Cost Of Failure Following Reimplantation After a 2-Stage Exchange Strategy For Hip Or Knee Prosthetic Joint Infection

Study Overview
=================
Brief Summary
-----------------
This study concerns patients having had an infection on their prosthesis (hip, knee,..) and for whom a 2-step exchange of prosthesis has been done. A 2-step exchange consists in explantation of the prosthesis and implementation of a spacer at the first stage, and reimplantation of a new prosthesis in a second stage. Patients with late prosthetic joint infection are at risk for superinfection at the time of reimplantation. The aim of this study is to determine the global cost of management of prosthetic joint infection.

Official Title
-----------------
Cost of Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection

Conditions
-----------------
Prosthetic Joint Infection

Intervention / Treatment
-----------------
* Other: Global cost of management of PJI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with prosthetic joint infection having had a 2-step exchange and managed at the CRIOAc from at least the reimplantation (between 2013 and 2015) Exclusion Criteria: -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Global cost of management of PJI<br> | Other: Global cost of management of PJI<br>* estimation of the global cost to manage PJI with 2-step exchange over 3 years<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Global cost of management of PJI | The following data are collected : duration of hospitalization at the Croix Rousse hospital (surgery unit, department of infectiology, other…) and in post-acute care structures, bacteriology, surgeries, medical treatments… and all acts realized throughout the management of the PJI. | Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption) | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
prosthetic joint infection
Study Evaluating BDDRFVIII and ReFacto AF in Hemophilia A

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine the relative bioavailability of ReFacto AF as compared to ReFacto, when each is administered as 2-minute bolus infusions.

Official Title
-----------------
A Single Dose, Randomized, Double-Blind, 2-Period Crossover Study in Patients With Hemophilia A to Evaluate the Pharmacokinetics of B-Domain Deleted Recombinant Human Factor VIII (BDDrFVIII) Manufactured by the Current Process (ReFacto) and by an Albumin Free Manufacturing Process (ReFacto AF)

Conditions
-----------------
Hemophilia A

Intervention / Treatment
-----------------
* Drug: ReFacto AF


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Severe hemophilia A (FVIII:C < 1% at local laboratory) Previously treated patients (PTP) with at least 250 exposure days to any factor VIII product Age greater than or equal to 12 years\ Exclusion Criteria: The presence of any bleeding disorder in addition to hemophilia A Concomitant therapy with immunosuppressant drugs (e.g., intravenous immunoglobulin (IVIG), routine systemic corticosteroid use) History of detectable factor VIII inhibitor

Ages Eligible for Study
-----------------
Minimum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: ReFacto AF|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Hemophilia
Swallow my Urine Back : Inhibition of Detrusor Overactivity by Swallowing Maneuver

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to find out whether swallowing has an effect on the degree of urinary urgency and on the amplitude of detrusor contraction during filling cystometry in patients with detrusor overactivity (DO).

Detailed Description
-----------------
Consecutive patients with DO will be included in this study. During urodynamics, the amplitude of the waves of DO will be documented and compared. At the beginning of the 2nd wave, patients will be asked to perform 5 repetitive swallows. Following each wave, patients will be asked to grade the severity of the urgency by a visual analogue scale (VAS).

Official Title
-----------------
Swallow my Urine Back : Inhibition of Detrusor Overactivity by Swallowing Maneuver

Conditions
-----------------
Overactive Detrusor

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with DO in filling cystometry antimuscarinic medications were requested to stop for 7 days before the cystometry Exclusion Criteria: none

Ages Eligible for Study
-----------------
Minimum Age: 30 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Urodynamics, Overactive Bladder
Detection of Motor Seizures Using WBAN

Study Overview
=================
Brief Summary
-----------------
This study aims to collect the motor movement data using sensors to detect Generalized Tonic Clonic Seizures . Wearable sensors similar to smart watches will be used to detect seizures. The proposed system will consist of 3-4 wearable wireless sensor worn on the hands and legs. The data from these sensors will be send to the clod and collected to a central hub for analysis and detection of GTC Seizures.

Detailed Description
-----------------
The key of the project is digital signal processing of the movement data collected. The medical application sensors from Analog Devices will be worn around the wrist and legs of the participants. These sensors will continuously collect the motor movement data. The data will be send to the cloud from where it will be collected at a central hub for digital signal processing and detection. The data analysis results will be compared with the standard EEG results for Tonic Clonic seizures and results will be verified.

Official Title
-----------------
Detection of Motor Seizures Using Wireless Body Area Network

Conditions
-----------------
Seizures, Tonic-Clonic

Intervention / Treatment
-----------------
* Device: Wearable sensors


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: subject has seizures or symptoms of seizures Exclusion Criteria:

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Measurement of Motor Movements<br>Wearable Accelerometer Sensors manufactured by leading manufacturers will be given to the participants to be worn around hands and legs. These sensors will be used to measure accelerations which will be impacted by the motor movements. | Device: Wearable sensors<br>* Wearable sensors will be given to the participants to be worn and movement data will be collected<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of Acceleration | Motor movements will cause changes in acceleration. Accelerometer sensors will be used to measure the acceleration as a first step towards detection of Tonic Clonic Seizures | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Digital Signal processing of the data | The raw acceleration data collected will be processed in a computer with MATLAB software using Digital Signal processing techniques. These techniques will help identify the data and differentiate the seizure movements from normal movements thereby helping to detect seizures data | 3 months |
Methods to Improve Preventative Care Uptake

Study Overview
=================
Brief Summary
-----------------
The proposed study examines whether providing patients with information on the incentives for following the preventative care guidelines available through their insurance has an impact on the update of these preventative services.

Official Title
-----------------
Methods to Improve Preventative Care Uptake

Conditions
-----------------
Health Knowledge, Attitudes, Practice

Intervention / Treatment
-----------------
* Other: Incentives mailer


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients attributed to the New York University Langone Health Clinically Integrated Network and have Medicare or Medicaid coverage (via Healthfirst) who are due for gaps in care Exclusion Criteria: Any patients who do not meet the inclusion criteria
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Incentives information provided<br> | Other: Incentives mailer<br>* Participants will receive a letter that describes the incentives provided by their health plan for following appropriate preventative care guidelines.<br>|
| No Intervention: No incentives information provided<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| % of care gaps closed |  | Up to 12 months |
RTLS Technology Study

Study Overview
=================
Brief Summary
-----------------
This study will examine the productivity of the hospital workforce utilizing a unique dataset that is stored at the Royal Wolverhampton Trust (RWT). The data is recorded by a Real Time Location System (RTLS) that tracks the second-by-second physical location of patients, staff, and medical equipment. Using this data, the plan is to measure the amount of time that clinical staff spend with patients and with other clinical staff, and then explore how these measures of contact time influence patient health outcomes. The data will also be used to measure the location and movement of patients during their hospital stay, and test the impact of moving patients between wards on their health outcomes. In light of the recent COVID-19 outbreak, impact of COVID19 on patient contact time, patient outcomes and professional working practices will also be examined.

Official Title
-----------------
A Retrospective, Observational Analysis Using Real Time Location Systems (RTLS) Technology to Explore the Effects of Clinical Staffing on Hospital Productivity and Patient Health Outcomes

Conditions
-----------------
Staff, Inpatients

Intervention / Treatment
-----------------
* Other: RTLS data


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients admitted to inpatient departments at RWT and are present at RWT during the period of 1 April 2016 to 31 March 2019 inclusive. Exclusion Criteria: Patients admitted to outpatient wards at RWT; Patients that were not admitted at or discharged from RWT between 1 April 2016 to 31 March 2019 inclusive.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Admitted inpatients<br>no intervention | Other: RTLS data<br>* data extraction from RTLS<br>|
| Staff with RTLS badges<br>no intervention | Other: RTLS data<br>* data extraction from RTLS<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of in-hospital deaths (RWT specific) | in-hospital mortality figures | 30 days | 
| Number of readmissions (RWT specific) | readmission figures | 30 days | 
| Length of stay | total amount of time in hospital | 3 years | 
| Nurse sensitive indicators | Number of Falls, medication errors, pressure ulcers and Urinary Tract Infections | 3 years | 
| Number of Adverse incidents affecting patient care | Number and description of Adverse incidents affecting patient care as recorded by the Datix information system (e.g. falls, medication errors) | 3 years |
Clinical Outcomes and Equality in Healthcare for Emergency General Surgery Patients Undergoing Emergency Laparotomy

Study Overview
=================
Brief Summary
-----------------
The goal of this retrospective observational cohort study is to evaluate the current standard of care for general surgerical patients undergoing emergency laparotomy and assess factors affecting clinical outcomes. The main questions it aims to answer are: what factors are associated with adverse post-operative events are patients treated differently based on sex or age This is a mapping of current standards of care prior to the implementation of a standardised care protocols for emergency laparotomy patients.

Official Title
-----------------
Improvement in Patient Survival and Equality in Care Provision for General Surgery Patients Undergoing Emergency Laparotomy - Can This be Achieved Through the Implementation of Standardised Care Protocols?

Conditions
-----------------
Abdomen, Acute

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Undergoing emergency laparotomy due to general surgical indication Exclusion Criteria: Children under 16 Trauma laparotomy Vascular or gynaecological indication for laparotomy

Ages Eligible for Study
-----------------
Minimum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Current routine of non-standardised laparotomy care<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| In-hospital mortality |  | 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| In-hospital serious complications |  | 30 days | 
| Long-term mortality |  | One year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Emergency laparotomy, General surgery, Clinical outcomes