linjc16/ctgov huggingface dataset:
A Prospective Evaluation of Iodinated Contrast Flow Patterns in Caudal Epidurography With Intentional Lateral Caudal Approach

Study Overview
=================
Brief Summary
-----------------
Caudal epidural block is useful not only for regional anesthesia of low abdominal, perineal area or lower extremities but for relieving acute or chronic pain of low back and lower extremities. Recently, there were some reports that there was a difference of the contrast flow pattern during lumbar epidural block according to a location of needle tip in the lumbar epidural space. Therefore, the investigators hypothesize that there is a difference of contrast flow pattern in caudal epidurography when a needle is inserted with intentionally lateral direction.

Conditions
-----------------
Patient Who Needs Epidural Block

Intervention / Treatment
-----------------
* Procedure: insertion needle via intentionally lateral direction.


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with unilateral radiculopathy Exclusion Criteria: patients with sepsis chronic infection coagulopathy local infection near the sacral hiatus the allergy of the contrast history of spine surgery, scoliosis and kyphosis

Ages Eligible for Study
-----------------
Minimum Age: 20 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| intentional lateral caudal approach<br> | Procedure: insertion needle via intentionally lateral direction.<br>* evaluation of iodinated contrast flow patterns in caudal epidurography with intentional lateral caudal approach<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| A prospective evaluation of iodinated contrast flow patterns in caudal epidurography with intentional lateral caudal approach | Caudal epidural block is useful not only for regional anesthesia of low abdominal, perineal area or lower extremities but for relieving acute or chronic pain of low back and lower extremities. Recently, there were some reports that there was a difference of the contrast flow pattern during lumbar epidural block according to a location of needle tip in the lumbar epidural space. Therefore, the investigator hypothesizes that there is a difference of contrast flow pattern in caudal epidurography when a needle is inserted with intentionally lateral direction. | during 10 seconds after obtaining the caudal epidurogram |
A Comparative Study of Mefloquine and S-P as Prophylaxis Against Malaria in Pregnant HIV + Patients

Study Overview
=================
Brief Summary
-----------------
Randomized controlled single blind prospective comparative study.

Detailed Description
-----------------
This study is intended to be a randomized controlled single blind prospective comparative study conducted to compare the efficacy of three, monthly doses of sulphadoxine-pyrimethamine as intermittent preventive therapy with Mefloquine as-intermittent preventive therapy in HIV-infected pregnant women.

Official Title
-----------------
A Comparative Study of Mefloquine and Sulphadoxine-pyrimethamine as Prophylaxis Against Malaria in Pregnant Human Immunodeficiency Virus Positive Patients

Conditions
-----------------
Malaria in Pregnant HIV + Patients

Intervention / Treatment
-----------------
* Drug: Mefloquine
* Drug: Sulphadoxine-Pyrimethamine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pregnant HIV positive patients Gestational age 16 weeks and above No history of use of Mefloquine or Sulphadoxine Pyrimethamine four weeks prior to recruitment. Exclusion Criteria: Anaemia packed cell volume less than 30% Pre -existing medical conditions- Diabetes Mellitus, -Hypertension Allergy to Sulphadoxine- Pyrimethamine or Mefloquine Non-consenting patients Multiple gestation Known psychiatric illness Known seizure disorder History of severe renal or hepatic disease

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Mefloquine<br>Tabs Mefloquine 250mg 3 doses 4 weeks apart | Drug: Mefloquine<br>* Tabs Mefloquine 250mg<br>* Other names: Larimef;|
| Active Comparator: Sulphadoxine-Pyrimethamine<br>500mg of Sulphadoxine and 25mg of Pyrimethamine 3tablets 4 weeks apart for 3 doses | Drug: Sulphadoxine-Pyrimethamine<br>* Sulphadoxine 500mg , Pyrimethamine 25mg<br>* Other names: Vitadar, Fansidar;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Level of malaria parasitemia in HIV positive women at delivery after administration of Mefloquine or sulphadoxine-pyrimethamine as prophylaxis for malaria in pregnancy |  | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Intermittent preventive therapy, malaria, pregnant, HIV positive, Prevention
Cardiac Output Measurement at the Conclusion of Cardiopulmonary Bypass

Study Overview
=================
Brief Summary
-----------------
Cardiac output, the amount of blood pumped by the heart in one minute, will be measured in pediatric patients undergoing surgery involving cardiopulmonary bypass (CPB). Cardiac output will be measured after cardiopulmonary bypass using a device that employs ultrasound dilution technology. At times, cardiac output will be measured during a procedure called modified ultrafiltration (MUF). The ultrasound dilution cardiac output measurements will be validated or compared with cardiac output measurements made using other FDA approved techniques and devices.

Official Title
-----------------
Ultrasound Dilution Cardiac Output at the Conclusion of Cardiopulmonary Bypass in Pediatric Patients

Conditions
-----------------
Cardiac Output

Intervention / Treatment
-----------------
* Device: HCE101 Cardiopulmonary Support Monitor


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Pediatric patients (age < 21 years) Pediatric patients undergoing surgery involving cardiopulmonary bypass Exclusion Criteria: Patients aged > 21 years Patients undergoing surgery off pump (not involving cardiopulmonary bypass)

Ages Eligible for Study
-----------------
Maximum Age: 21 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Pediatric cardiac output (CO) after CPB<br>Cardiac output measurements made in pediatric patients after cardiopulmonary bypass. | Device: HCE101 Cardiopulmonary Support Monitor<br>* Measurement of cardiac output using ultrasound dilution technology. The ultrasound dilution technology is in the HCE101 Cardiopulmonary Support Monitor.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiac output after cardiopulmonary bypass | Cardiac output will be measured in pediatric patients after undergoing surgery involving cardiopulmonary bypass | Less than 10 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
cardiac output, cardiopulmonary bypass, ultrasound dilution
An Analysis of Urinary Proteases as Biomarkers for Hepatocellular Carcinoma-101423

Study Overview
=================
Brief Summary
-----------------
Specific urine proteases or groups of these enzymes can be reliable biomarkers and an effective gauge of response to therapy in patients with hepatocellular carcinoma.

Official Title
-----------------
An Analysis of Urinary Proteases as Biomarkers for Hepatocellular Carcinoma-101423

Conditions
-----------------
Hepatocellular Carcinoma, Liver Disease

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Ability and willingness to provide written informed consent Must be between 18-90 years of age at the time of consent Ability to provide urine specimen at protocol-defined timepoints Must have treatment interventions planned that are directly related to liver disease (excluding those assigned to group 3-Controls) Exclusion Criteria: Suspected inability, e.g. unwillingness to comply with study procedures or unwillingness to provide written consent

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| group A<br>Patients with known HCC | |
| Group B<br>Patients with liver disease but no HCC | |
| Group C<br>Control; patients with no known liver disease or HCC | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
HCC, Liver Disease without HCC
Effect of Cognitive Behavioural Therapy (CBT) for Children With Autistic Spectrum Disorders

Study Overview
=================
Brief Summary
-----------------
Cognitive Behavioural Therapy is an effective intervention program for children with High-Functioning Autistic Spectrum Disorder to remediate anxiety issues.

Official Title
-----------------
A Randomised Controlled Trial on the Effect of Cognitive-behavioural Therapy for High-functioning Children With Autistic Spectrum Disorder

Conditions
-----------------
Autism Spectrum Disorder, Anxiety

Intervention / Treatment
-----------------
* Behavioral: Cognitive Behavioural Therapy
* Other: Social Recreational


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Assessed to have Autistic Spectrum Disorder, Asperger Syndrome, Pervasive Developmental Disorder, Not Otherwise Specified by the DSM-IV criteria, based on clinical interview, Asperger Syndrome Diagnostic Scale (ASDS) or Autism Diagnostic Observation Schedule (ADOS) Child have a Verbal Comprehension Index of 80 and Perceptual Reasoning Index of 90 and above No change of medication dosage 1 month prior to the commencement of program for the child and through out the duration of the study Written parental consent and assent from children above 12 years old Exclusion Criteria: Children with Verbal Comprehension Index of 80 and Perceptual Reasoning Index of 90 and below. Children who are undergoing other Cognitive Behavioural treatment program concurrently Those without parental consent will not be able to participate

Ages Eligible for Study
-----------------
Minimum Age: 9 Years
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Treatment Group - CBT<br> | Behavioral: Cognitive Behavioural Therapy<br>* 16 weekly sessions of 1.5 hrs in small groups of 3-4 children conducted by 2 therapists<br>|
| No Intervention: Control Group<br> | Other: Social Recreational<br>* 16 weekly sessions of 1.5 hrs in small groups of 3-4 children, conducted by 2 therapists<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anxiety level of child |  | Pre Treatment, Post-treatment, 3 months follow-up, 6 months follow-up, One year follow-up | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Parent Stress Level |  | Pre Treatment, Post-treatment, 3 months follow-up, 6 months follow-up, One year follow-up | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
High-Functioning Autistic Spectrum Disorder, Anxiety, Cognitive Behavioural Therapy, Social Recreational, Parent Stress
Exercise and Repetitive Diving

Study Overview
=================
Brief Summary
-----------------
SCUBA diving frequently involves repetitive exposures over multiple days. The goal of this study was to see how exercise impacts microparticles (MPs), endothelial function, and venous gas emboli (VGE) over a series of dives. 16 divers in 2 groups each completed 6 dives. One group completed 3 control dives followed by 5 days rest then 3 dives preceded by exercise. The other group completed the opposite protocol. Flow-mediated dilation (FMD) data and blood for MP analysis was collected before and after each dive. VGE were monitored via transthoracic echocardiography 30, 60, and 90 min after surfacing. Exercise before diving consisted of 60 min running outdoors including 8x4 min intervals at 90% VO2max effort.

Official Title
-----------------
The Impact of Predive Exercise on Repetitive SCUBA Diving

Conditions
-----------------
Neutrophil Activation, Venous Gas Emboli, Decompression Sickness, Endothelial Dysfunction

Intervention / Treatment
-----------------
* Other: Aerobic running exercise


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Certified SCUBA diver Certified to dive by experienced Medical evaluator Must be able to run continuously for 45 min Exclusion Criteria: Prior diagnosis of decompression sickness

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Control dives 1st<br>Subjects in this group complete the first 3 dives as control dives and the second 3 dives preceded by aerobic exercise | Other: Aerobic running exercise<br>* 60 min of aerobic intervals completed prior to SCUBA diving<br>|
| Experimental: Predive exercise 1st<br>Subjects complete the first 3 dives preceded by the intervention of aerobic exercise and the second 3 with no exercise as control dives | Other: Aerobic running exercise<br>* 60 min of aerobic intervals completed prior to SCUBA diving<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in circulating microparticle counts | Change in circulating microparticle counts measured pre and post SCUBA diving following 6 dives spaced over 12 days | 2 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
SCUBA diving, Exercise, Microparticles, Repetitive diving, Endothelial function
Executive Function in Preterm Born Children: An Integrative Approach From Genetics to Brain Function

Study Overview
=================
Brief Summary
-----------------
Hd-EEG and MRI measures are used to study the maturation of functional networks in order to identify the neural circuits underlying executive and memory processes in children born preterm. It will be determined whether children born preterm with executive function deficits will have an abnormal connectivity between basal ganglia and cortex due to WM injury. Moreover, the development of hd-EEG activity during sleep (coherence and travelling waves) and brain maturation of children and adolescents born preterm will be compared with the respective measures in healthy controls. This is of eminent importance as it helps to understand the nature of executive function and hence, it may help to develop neuroprotective strategies to prevent executive function deficits in these infants.

Conditions
-----------------
Preterm Infants

Intervention / Treatment
-----------------
* Other: MRI, EEG and cognitive testing


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Schoolchildren between 10 and 12 or 14 and 16 (born between 1996 and 1998 or between 2000 and 2002) Preterm group: born <32 weeks of gestation Control group: siblings or friends of preterm group in one of the two age groups Exclusion criteria: Preterm Group: MDI < 85 at 5 years of age; cerebral palsy Control Group: born <37 weeks of gestation

Ages Eligible for Study
-----------------
Minimum Age: 10 Years
Maximum Age: 16 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Children/adolescents born preterm<br> | Other: MRI, EEG and cognitive testing<br>* Sleep EEG and one MRI, executive function testing using Strrop test, BRIEF questionnaire and CantabEclipse<br>|
| Control children and adolescents<br> | Other: MRI, EEG and cognitive testing<br>* Sleep EEG and one MRI, executive function testing using Strrop test, BRIEF questionnaire and CantabEclipse<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Executive functions
Photoplethysmography Detects Changes in Vascular Tone

Study Overview
=================
Brief Summary
-----------------
Changes in the vascular tone of anesthetized patients is common and cause hemodynamic problems. The monitoring of such changes in vascular resistance using simple and non-invasive tools is lacking. The present study was designed to determine if photoplethysmography can detect changes in the systemic vascular resistance using Doppler as the reference method.

Detailed Description
-----------------
This is a prospective and observational study designed to test the reliability of photoplethysmography to diagnose changes in the vascular resistance during anesthesia. The investigators will studied 50 mechanically ventilated patients undergoing general anesthesia. Photoplethysmography will be continuously recorded in the right thumb during anesthesia. Duplex color and power Doppler will measure flow in the radial artery of the right hand.The contour analysis of both, photoplethysmogram and radial artery flow will be analyzed, correlated and compared using the Bland-Altman plot.

Official Title
-----------------
Accuracy of Photoplethysmography to Detect Changes in Vascular Tone: a Doppler Study

Conditions
-----------------
Vascular Diseases

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Written Inform Consent Programmed surgery Supine position Exclusion Criteria: Emergency surgery Peripheral vascular diseases

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients undergoing general anesthesia<br>Patients ASA 1-3, undergoing different types of general anesthesia, in supine position, with standard or advanced hemodynamic monitoring. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Accuracy of photoplethysmography for the assessment of systemic vascular tone | Comparison between pletysmography with the reference Doppler method | 5 hours |
Shanghai Children and Adolescent Diabetes Eye Study

Study Overview
=================
Brief Summary
-----------------
To compare the prevalence of eye disease between children and adolescents with diabetes mellitus and healthy people, and to analyze the related factors of eye diseases in diabetic patients.

Detailed Description
-----------------
A cohort study. From January 2018 to 2028, 300 cases of diabetic children in Children's Hospital of Fudan University in Shanghai will be selected as case group, and 300 healthy children without diabetes will be selected as the control group. The purpose of the study is to guide and regulate eye health screening of children and adolescents with diabetes in Children's Hospital of Fudan University in Shanghai, build up the ranks with the general practitioner as the backbone combined, and provide comprehensive, continuous, and dynamic information service to diabetic eye disease health management. We expect to reduce the prevalence rate of diabetic eye disease, blindness and visual impairment of DR, and improve diabetics consciousness of eye health maintenance, thus upgrading the level of eye disease prevention and treatment in Shanghai.

Official Title
-----------------
Shanghai Children and Adolescent Diabetes Eye Study

Conditions
-----------------
Diabetes Mellitus, Eye Diseases

Intervention / Treatment
-----------------
* Diagnostic Test: Diabetes mellitus


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: (1) provision of a written informed consent by a guardian; (2) age over 5 years and less than 18 years; (3) diagnosis of type 1 or type 2 diabetes based on the WHO diagnostic criteria for cases. Exclusion Criteria: (1) eyelid diseases - eyelid entropion, eyelid ectropion, eyelid, ptosis, and palpebral dyskinesia; (2) conjunctival diseases - pterygium and conjunctivitis; (3) history of ocular surface chemical injury or use of eye drops with moisturizing artificial tears; (4) history of eye surgery within 6 months or history of retinal laser photocoagulation; (5) systemic diseases - Sjogren syndrome, Parkinson's disease, rheumatoid arthritis, Grave 's disease, systemic lupus erythematosus, and others.

Ages Eligible for Study
-----------------
Minimum Age: 5 Years
Maximum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Case group<br>Children and adolescents with diabetes mellitus | Diagnostic Test: Diabetes mellitus<br>* Children and adolescents who is diagnosed with diabetes will be involved in case-group, and others will be involved in control-group.<br>|
| Control group<br>Children and adolescents without diabetes mellitus | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diabetic eye diseases | Prevalence of eye diseases due to diabetes. | January 1, 2028 |