Hormonal Regulation of Postpartum Weight and Presence of Gut Peptides in Human Milk

Study Overview
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Brief Summary
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Hormonal Regulation of Postpartum Weight and Presence of Gut Peptides in Human Milk Studies suggest that childbearing is an important contributor to the development of obesity in many women and that breastfeeding may be protective. Ghrelin and peptide YY (PYY) are gut hormones involved in appetite regulation and energy homeostasis and are biological neuroendocrine signals that potentially affect body weight and adiposity/

Detailed Description
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Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk. This study evaluated whether fasting or postprandial ghrelin or PYY is different between lactating and nonlactating postpartum women matched for age, body weight, and adiposity. Eligibility Criteria: Healthy females, 18+ years old, non-smokers, no major food allergies, first-time mom, currently pregnant or within 1 month of giving birth.

Official Title
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Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk

Conditions
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Maternal Obesity Syndrome

Intervention / Treatment
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* Other: cross-sectional


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy women (non-smokers) at least 18 years old who did not have any pregnancy complications, and gave birth to their first child within one month. The study is open to women who are breastfeeding or formula feeding. Exclusion Criteria: Smoker, had twins or triples, had any major complication of pregnancy(example, gestational diabetes); have kidney, liver, hormonal, stomach, intestine,lung, heart or blood disease. This also includes high blood pressure; use prescription or over-the-counter medicine or herbal drinks or pills. History of depression, anxiety, disordered eating, other psychological problems, alcoholism or other substance abuse. Severely claustrophobic. Having a strong fear of needles and/or do not feel you can have blood drawn every 30 minutes from a plastic catheter. Are not able to or willing to fully participate in the study, and are pregnant, anemic or have a thyroid problem.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: Four weeks Postpartum Lactating<br>women between 18 and 45 who delivered their first child 4 weeks prior and who were currently lactating and planning to lactate for one year postpartum. | Other: cross-sectional<br>* Monitoring two recently discovered appetite hormones called ghrelin and neuropeptide YY (PYY). This study evaluated whether fasting or postprandial ghrelin or PYY is different btween lactating and nonlactating postpartum women matched for age, body weight, and adiposity.<br>|
| Other: Control Never Pregnant<br>women between 18 and 45 who have never been pregnant | Other: cross-sectional<br>* Monitoring two recently discovered appetite hormones called ghrelin and neuropeptide YY (PYY). This study evaluated whether fasting or postprandial ghrelin or PYY is different btween lactating and nonlactating postpartum women matched for age, body weight, and adiposity.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk | Biomedical Research Study that will provide information on reducing maternal obesity. | 5 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Human milk, Ghrelin,PYY and maternal obesity.