Drug Use Evaluation of Clindamycin in Critical Care Units in Alexandria Main University Hospital

Study Overview
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Brief Summary
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Irrational use of antibiotics is a one of the main health system problems,it leads to antibiotic resistance,increasing antibiotics side effects and the total cost. This study is a medication use evaluation study aims to evaluate intravenous clindamycin prescribing practice in critical care units in Alexandria Main University Hospital.

Official Title
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Drug Use Evaluation Study of Clindamycin in Critical Care Units in Alexandria Main University Hospital

Conditions
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Infection, Bacterial

Intervention / Treatment
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* Drug: Clindamycin Injection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adults 18 years old or more . Patients on clindamycin as an empirical treatment. Patients started clindamycin as an emperical treatment in other departments but the physician approved to continue it in critical care. Exclusion Criteria: Children (less than 18 years old) Patients started clindamycin as a defenitive treatment (based on microbiological culture results).

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Drug: Clindamycin Injection|it is a clindamycin use evaluation study|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the number of prescriptions with appropriate indications of clindamycin will be counted during the retrospective observation of all prescriptions | appropriateness of clindamycin indication will be determined according to IDSA guidelines. | 1 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the number of prescriptions with duplication of therapy with clindamycin will be counted during the retrospective observation of all prescriptions | duplication of therapy means prescribing of clindamycin concurrently with another antibiotic to target the same microorganism. | 1 month | 
| the number of patients who had diarrhea as a main side effect of clindamycin | diarrhea is a main side effect of clindamycin so in the study the number of patients who had diarrhea will be counted during the retrospective observation of all prescriptions | 1 month | 
| the number of patients who had severe drug interactions with clindamycin | in the study the number of patients who severe clindamycin drugs interactions will be counted during the retrospective observation of all prescriptions | 1 month | 
| Total clindamycin DDD defined daily doses and clindamycin defined daily doses per 1000 patients days. | Defined daily doses measurement of a drug is an indicator put by WHO , it indicates the consumption of this drug in a hospital or a department and defined daily doses per 1000 patients days indicates the consumption of this drug in relation to the total number of patients in a certain period of time. | 1 month | 
| to calculate the total cost of clindamycin. | The cost of clindamycin treatment courses of all patients will be calculated in the Egyptian pound | 1 month |