Neuromuscular Ultrasonography Utility for Detection of Peripheral Neuropathy in Systemic Lupus Erythematosus

Study Overview
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Brief Summary
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This study aims to evaluate the rule of NMUS in detection of peripheral neuropathy in SLE patient and to correlate it to traditional neurophysiological studies, clinical signs and activity of SLE.

Detailed Description
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The frequency of SLE peripheral neuropathy documented by electrophysiology has been estimated to be approximately 30%. The term peripheral neuropathies include symmetric polyneuropathy, single and multiple mononeuropathy, and radiculopathy. There has been increasing interest in using ultrasonography (US) to aid peripheral neuropathy diagnosis and studies have shown good correlation with other imaging modalities. US is a non-invasive and inexpensive imaging device that has become widely available as a diagnostic tool at many fields. so systemic lupus patients were enrolled in the study , performed nerve conduction study and neuromuscular ultrasound for bil. median, ulnar, peroneal, tibial and sural nerves , on statistics the cross sections were compared in neurophusiologically affected and non affected nerves, also the sensitivity and specifity of NMUS in comparison to the traditional NCS was calculated

Official Title
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Neuromuscular Ultrasonography Utility for Detection of Peripheral Neuropathy in Systemic Lupus Erythematosus

Conditions
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Peripheral Neuropathy, System; Lupus Erythematosus

Intervention / Treatment
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* Diagnostic Test: neuromuscular ultrasound


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: All adult SLE patients who was admitted to Rheumatology & Rehabilitation department of Assuit university hospital during time frame of study. apparently healthy subjects with normal electrophysiological study verbal consent, free and informed Exclusion Criteria: • Other causes of peripheral neuropathy: Traumatic Purely degenerative Diabetic Toxic Infections Drug induced

Ages Eligible for Study
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Minimum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| systemic lupus patients<br>Nerve conduction study and neuromuscular ultrasound for median , ulnar, tibial, peroneal and sural nerves | Diagnostic Test: neuromuscular ultrasound<br>* ultrasound to visualize the peripheral nerves of lupus patients and to compare it with results of the raditional electrophysiological studies<br>* Other names: nerve conduction study;|
| Healthy subjects<br>Nerve conduction study and neuromuscular ultrasound for median , ulnar, tibial, peroneal and sural nerves | Diagnostic Test: neuromuscular ultrasound<br>* ultrasound to visualize the peripheral nerves of lupus patients and to compare it with results of the raditional electrophysiological studies<br>* Other names: nerve conduction study;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| evaluate the rule of NMUS in detection of peripheral neuropathy in SLE patient | Measuring sensitivity and specificity of neuromuscular ultrasound in comparison to nerve conduction study | 6months | 
| Describing the patterns of peripheral nerve affection in SLE patient | Evaluating different studied nerves clinically, electrophyiologically and by neuromuscular ultrasonography | 6months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Neuromuscular ultrasound, SLE, Peripheral neuropathy