The Roles of Prostanoids in Patients With Sleep Apnea Syndrome

Study Overview
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Brief Summary
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The purpose of this study is to evaluate the relationships between prostanoids and various outcomes such as sleep disturbance, hypertension and arteriosclerosis in patients with sleep apnea syndrome(SAS). In the patients introduced to continuous positive airway pressure(CPAP) treatment, the effects of CPAP are also evaluated.

Detailed Description
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SAS is characterized by abnormality during sleep and hypoxemia from apnea and hypopnea, followed by systemic inflammation and organ dysfunction like cardiovascular diseases. Systemic inflammation causes the activation of arachidonic acid metabolism, producing prostaglandins (PGs) and leukotrienes (LTs). In addition, significant relationships between PGD2 and PGE2 and sleep, PGF2α and hypertension, PGI2 and thromboxane and platelet aggregation and so on are reported. Therefore, it is hypothesized that many prostanoids affect the pathophysiology of SAS. However, the relationships between prostanoids and clinical outcomes in patients with SAS are unknown. Although CPAP is the major treatment of SAS, the effects of CPAP on prostanoids are not known, either. Thus, the purpose of this study is to evaluate those relationships.

Official Title
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The Investigation of the Roles of Prostanoids in Patients With Sleep Apnea Syndrome

Conditions
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Sleep Apnea

Intervention / Treatment
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* Device: CPAP treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects hospitalized in Kyoto University Hospital for careful examination of SAS Exclusion Criteria: Subjects with severe respiratory diseases, severe heart diseases, severe vascular diseases, or severe diabetes mellitus. Subjects taking nonsteroidal anti-inflammatory drugs, steroids or immunosuppressants.

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: CPAP<br>the subjects introduced with CPAP treatment | Device: CPAP treatment<br>* CPAP treatment is to improve airway obstruct for obstructive sleep apnea, and after 3 months' treatment, we evaluate the effects.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| metabolites of arachidonic acid in the urine and blood |  | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Polysomnography measurements |  | 3 months | 
| Sleepiness and health-related quality of life |  | 3 months | 
| Blood pressure and pulse rate |  | 3 months | 
| Endothelial dysfunction |  | 3 months | 
| Platelet aggregation |  | 3 months | 
| Cardiac and neck echo cardiography |  | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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CPAP, sleep apnea syndrome, prostanoids