Glucose, Whey Protein and Time to the Next Meal on Mealtime Food Intake in Children

Study Overview
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Brief Summary
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The investigators hypothesize that glucose and whey protein given 30 and 60 min before a pizza meal will exert different effects on food intake in adolescent children, and will depend on pubertal stage. Food intake will be measured at 30 and 60 min following a glucose(0.75 g of glucose/kg body weight), whey protein (0.75 g of glucose/kg body weight) or sweetened noncaloric beverage. Subjective appetite will be measured as well.

Official Title
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The Effect of Glucose, Whey Protein and Time to the Next Meal on Food Intake and Subjective Appetite in Normal Weight and Overweight/Obese Children

Conditions
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Obesity

Intervention / Treatment
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* Dietary Supplement: water with glucose
* Dietary Supplement: water and whey protein
* Dietary Supplement: water with noncaloric sweetener


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: children with no emotional, behavioral or learning problems Exclusion Criteria: underweight children children with emotional, behavioral or learning problems children who dislike foods in study

Ages Eligible for Study
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Minimum Age: 9 Years
Maximum Age: 14 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: noncaloric beverage<br>noncaloric sweetened beverage administered 30 min prior to mealtime | Dietary Supplement: water with noncaloric sweetener<br>* 0.15 g of sucralose added to water<br>|
| Experimental: noncaloric beverage (60 min)<br>noncaloric sweetened beverage administered 60 min prior to mealtime | Dietary Supplement: water with noncaloric sweetener<br>* 0.15 g of sucralose added to water<br>|
| Experimental: glucose beverage<br>glucose beverage administered 30 min prior to mealtime | Dietary Supplement: water with glucose<br>* 0.75 g/kg body weight of glucose added to water<br>|
| Experimental: glucose beverage (60 min)<br>glucose beverage administered 60 min prior to mealtime | Dietary Supplement: water with glucose<br>* 0.75 g/kg body weight of glucose added to water<br>|
| Experimental: whey protein beverage<br>whey protein beverage administered 30 min prior to mealtime | Dietary Supplement: water and whey protein<br>* 0.75 g/kg body weight of whey protein added to water<br>|
| Experimental: whey protein beverage (60 min)<br>whey protein beverage administered 60 min prior to mealtime | Dietary Supplement: water and whey protein<br>* 0.75 g/kg body weight of whey protein added to water<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Food intake (kcal) |  | 30 and 60 min after the treatment | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| subjective appetite |  | 0-120 min |