linjc16/ctgov huggingface dataset:
Surveillance Study of Acute Gastroenteritis in Hospitalized Children

Study Overview
=================
Brief Summary
-----------------
Acute gastroenteritis is a common cause of hospital admission and health office visits and have a huge burden on the economy of developing countries. The investigators proposed this observational prospective study during summer period in a community and tertiary care hospital in a rural area of Lebanon to investigate the etiologies and age distribution of admitted cases to general pediatric floor from the age of 1 month up to the age of 14 years.

Official Title
-----------------
Surveillance Study of Acute Gastroenteritis Etiologies in Hospitalized Children

Conditions
-----------------
Acute Gastroenteritis, Diarrhea, Dehydration

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: acute gastroenteritis Exclusion Criteria: immunodeficiency malnutrition

Ages Eligible for Study
-----------------
Minimum Age: 1 Month
Maximum Age: 13 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| etiologies | to determine the microbial causes of acute gastroenteritis | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
diarrhea, vomiting, fever, abdominal pain, oliguria
Ketamine Long Therm Follow Up Study

Study Overview
=================
Brief Summary
-----------------
Results of the study and of 5 years follow up of depressed patients who participated in the study during 2014-2015. We will locate the participants and will interview them will use the same questionnaires to evaluate their depressive symptoms. We will also measure the time to relapse.

Detailed Description
-----------------
Anamnestic data will be collected from the patients, in addition, depressive symptoms will be measured using Montgomery Asberg Depression Scale (MADRAS). In addition, the Clinical Global Severity Scale (CGI-S) and Clinical Global Improvement (CGI-I) were performed 2 hours after treatment. In addition, we performed to prolong the time to relapse in this patient.

Official Title
-----------------
Five Years Follow up: Add on Intravenous Ketamine for Major Depressive Disorder

Conditions
-----------------
Followin Ketamine Treatment

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Participants in the ketamine study Exclusion Criteria: -

Ages Eligible for Study
-----------------
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Time to relapse | Medications | 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Major Depressive Disorder, ketamine, follow up, relapse
Role of the Nasal Environment in Obesity

Study Overview
=================
Brief Summary
-----------------
The primary aim of this study is to investigate the nasal environment in obese and lean individuals.

Official Title
-----------------
Role of the Nasal Microbiota in Obesity - the microNASA Study

Conditions
-----------------
Adiposity

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: N=50 adult male and female patients with obesity will be included in this study. Inclusion criteria: Inclusion criteria: Age 18-55 years Written informed consent BMI > 30 kg/m2 N=50 adult lean patients age- and sex-matched to the group of obese patients will be included in this study. Inclusion criteria: Age 18-55 years Written informed consent BMI 18-25 kg/m2 N=50 adult male and female patients with obesity with scheduled bariatric will be included in this study Inclusion criteria: Age 18-55 years Written informed consent BMI > 35 kg/m2 Exclusion Criteria: Smoking Chronic or acute sinusitis Surgical intervention of the nasal cavity or the paranasal sinus Use of antibiotics within the last 31 days18 Current illicit drug abuse including daily marijuana or CBD consumption (≤ 24 g of alcohol per day allowed) Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease) Use of any kind of decongestant more than twice a week Use of cortisone-containing nasal spray within the last 3 months Acute allergic rhinitis History of neurodegenerative diseases History of severe head trauma Severe renal impairment (e.g. estimated glomerular filtration rate <30 ml/min/m2)

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Obese<br>Obese participants with BMI >30 | |
| Lean<br>Lean participants with a BMI <25 | |
| Bariatric<br>Participants with scheduled bariatric surgery. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in nasal microbiota composition | The microbiome of the nasal cavity will be analyzed by isolating DNA from Nasal Swabs through amplicon sequencing. We will define the primary endpoint as the difference in nasal microbiome in obese vs. sex- and age-matched lean control individuals. | 6 Months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in nasal microbiota Composition after bariatric surgery | The microbiome of the nasal cavity will be analyzed by isolating DNA from Nasal Swabs through amplicon sequencing. We will define the primary endpoint as changes in nasal microbiome in obese patients before and 1, 3, 6 and 12 month after bariatric surgery. | 24 Months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Adiposity, Olfactory Function, Microbiome
Influence of Central Sensitization on Efficacy of Patient-controlled Epidural Analgesia in Osteoarthritis Patients Undergoing Total Knee Replacement

Study Overview
=================
Brief Summary
-----------------
Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central sensitization. The degenerative joint disease, osteoarthritis, with characteristic destruction of cartilage and alteration in bone is a very common cause of chronic pain. The degree of pain does not always correlate with the extent of joint damage or presence of active inflammation raising the possibility that there may be a central component to the pain. The central sensitization inventory (CSI) is a new self-report screening instrument to measure the degree of central sensitization, and to help identify patients with central sensitivity syndromes. The aim of this investigation is to evaluate the influence of preoperative central sensitization, which represented by CSI score, on postoperative pain score in osteoarthritis patients undergoing total knee replacement who receiving patient-controlled epidural analgesia.

Conditions
-----------------
Knee Osteoarthritis

Intervention / Treatment
-----------------
* Procedure: CSI score < 40
* Procedure: CSI score ≥ 40


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Aged 20 to 80 years osteoarthritis patients undergoing total knee replacement under spinal anesthesia, and who receiving postoperative epidural PCA Exclusion Criteria: refusal coagulopathy neurologic deficit preoperative opioids medication recent analgesics change

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| CSI score < 40<br>CSI cutoff value<40 | Procedure: CSI score < 40<br> <br> |
| Group 2: CSI score ≥ 40<br>CSI cutoff value≥40 | Procedure: CSI score ≥ 40<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peak pain score | Numeric rating scale (0 to 10 points) at each assessment interval | at the point of Epidural PCA to postoperative 1-48 h | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
central sensitization; osteoarthritis; epidural analgesia
Utility Study in Diffuse Large B-Cell Lymphoma (DLBCL)

Study Overview
=================
Brief Summary
-----------------
This study is a prospective, cross-sectional survey to be administered to real patients in remission from DLBCL using a 15-minute postal or online survey. The project is designed to describe the impact of DLBCL remission on health utility and quality of life. Data collection will occur over a 4-month period.

Official Title
-----------------
UK Utility Study in Diffuse Large B-Cell Lymphoma

Conditions
-----------------
Diffuse Large B-Cell Lymphoma

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adults greater than or equal to (>/=) 18 years of age Diagnosis of DLBCL and currently in first remission Prior drug treatment for DLBCL Exclusion Criteria: Receiving active treatment for DLBCL Relapsed following any treatment for DLBCL

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| DLBCL Participants<br>A cohort of approximately 100 patients in first remission with DLBCL will complete questionnaires through a 15-minute postal or online survey. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health-Related Quality of Life According to European Quality of Life 5-Dimension 5-Level (EQ-5D-5L) Score |  | Up to 4 months of data collection |
Effects of Kalaripayattu on Psychological Wellbeing and Behavior in Children

Study Overview
=================
Brief Summary
-----------------
Kalaripayattu is an ancient martial art of India which has been practiced for centuries. It is mentioned in Vedic litrature of Ayurveda,Dhanurveda and Yoga. The main elements of Kalaripayattu include training in physical, combat, breathing exercises, higher form of meditation and specific class of medical treatments. The purpose of the experimental study is to determine the effect of kalaripayattu on psychological well-being and behaviour in children.

Official Title
-----------------
Effects of Kalaripayattu on Psychological Wellbeing and Behavior in Children: Randomised Wait- List Control Trial

Conditions
-----------------
Psychological, Behavior

Intervention / Treatment
-----------------
* Other: Kalaripayattu


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Children from 8 years to 12 years of age Parents agreed to informed consent Exclusion Criteria: Physical disabilities Diagnosed Mental or behavioural disorder Practicing other exercise, physical trainings or yoga

Ages Eligible for Study
-----------------
Minimum Age: 8 Years
Maximum Age: 12 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: kalaripayattu<br>The experimental groups will treated with kalaripayattu exercises for the period of 12 weeks | Other: Kalaripayattu<br>* Combination of Exercise, breathing, meditation, combat practices<br>|
| No Intervention: Wait list control<br>Control group will not be given any intervention. After the treatment period is over, all the subjects will be given Kalaripayattu training. | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Psychological Well-being | Measured by MacArthur Health and Behavior Questionnaire | Change from baseline to 12 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Behavior | Measured by Child Behavior Scale | Change from baseline to 12 weeks |
The Effect of Cycling Off Criteria During Pressure Support Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients

Study Overview
=================
Brief Summary
-----------------
The investigators' aim is to study the effect of cycling off criteria during pressure support ventilation in COPD patients at two levels of PEEP and PSV.

Detailed Description
-----------------
In this study two levels of cycling off criteria at two levels of PEEP and PSV were tested in term of gas exchange, respiratory mechanics, work of breathing and patient comfort.

Official Title
-----------------
The Effect of Cycling Off Criteria During Pressure Support Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients

Conditions
-----------------
Chronic Obstructive Pulmonary Disease

Intervention / Treatment
-----------------
* Procedure: mechanical ventilation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Stable COPD patients during invasive mechanical ventilation Exclusion Criteria: Hemodynamic instability, Paralysis

Ages Eligible for Study
-----------------
Minimum Age: 16 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>COPD patients | Procedure: mechanical ventilation<br>* evaluated the effect of two different cycling off criteria on breathing pattern, respiratory effort, and gas exchange in patients with chronic obstructive pulmonary disease<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Respiratory mechanics, gas exchange |  | 2 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comfort of breathing |  | 2 minutes | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
gas exchange, pressure support ventilation, respiratory mechanics, COPD patients
Comparison of Two Summative Assessment Methods in Advanced Life Support Courses

Study Overview
=================
Brief Summary
-----------------
Several approaches for summative assessment during Advanced Life Support courses are used. The most commonly used method during European Resuscitation (ERC) Council Life Support Courses is that 1 instructor is miming a whole team, and the candidate has to lead this team through a scenario; another variant of the summative assessment (mainly used by American Heart Association (AHA) Courses) is with a group of students, where one student is the team leader to be assessed and the others are his team not being assessed. The second approach might be more realistic; however there is no evidence around with regard to effectiveness (pass/fail rate, ability to test non-technical skills (NTS)) or participant/assessor satisfaction.

Official Title
-----------------
Comparison of Two Summative Assessment Methods in Advanced Life Support Courses - a Randomized Controlled Trial

Conditions
-----------------
Self-Assessment

Intervention / Treatment
-----------------
* Other: assessment


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: All medical students at the University of Bern, study year 2017/2018, 5th and 6th study year Exclusion Criteria: Refusal to participate
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: ERC<br>Assessment as used by the European Resuscitation Council | Other: assessment<br>* different assessments in both arms<br>|
| Other: AHA<br>Assessment as used by the American Heart Association | Other: assessment<br>* different assessments in both arms<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Team leadership | Subjective rating of team leadership | 1 minute after the assessment is completed |
Efficacy and Safety of Ethanol Lock Therapy for the Prevention of Central Line-associated Bloodstream Infections

Study Overview
=================
Brief Summary
-----------------
Patients on long-term parenteral nutrition (PN) are at high risk for central line-associated bloodstream infections (CLABSI). This study evaluates the efficacy and safety of ethanol lock therapy for CLABSI prophylaxis in adult patients on PN.

Official Title
-----------------
Efficacy and Safety of Ethanol Lock Therapy for the Prevention of Central Line-associated Bloodstream Infections

Conditions
-----------------
Catheter-Related Infections

Intervention / Treatment
-----------------
* Other: Ethanol lock
* Other: Heparin lock


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Adult patients (ages 18-80) on PN with silicone-based central venous catheters Exclusion Criteria: Weight ≤ 50 kg Allergy/hypersensitivity/intolerance to ethanol or heparin Pregnancy or breastfeeding Patient taking metronidazole, disulfiram, or isoniazid History of alcohol abuse History of heparin-induced thrombocytopenia (HIT) or have an active hypocoagulable state

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Ethanol lock<br>70% ethanol | Other: Ethanol lock<br> <br> |
| Active Comparator: Heparin lock<br>Heparinized saline (100 U/mL) | Other: Heparin lock<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Central line-associated bloodstream infection |  | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Hospitalization |  | 12 months | 
| SIRS/sepsis |  | 12 months | 
| Catheter-related complication |  | 12 months | 
| New self-reported symptoms |  | 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
ethanol lock, parenteral nutrition
Fecal Microbiota Transplantation on Type 2 Diabetes Mellitus

Study Overview
=================
Brief Summary
-----------------
The gut microbiota is considered to constitute a microbial organ which has pivotal roles in the body's metabolism. Evidence from animal and human studies strongly support the link between intestinal bacteria and type 2 diabetes mellitus. The present clinical trial aims to re-establish a gut functionality state of intestinal flora through fecal microbiota transplantation.

Detailed Description
-----------------
We established a standard bacteria isolation from donated fresh stool in lab.Then the bacteria is transplanted to mid-gut (at least below the second part of duodenum ) through regular gastroscope. Participants in this study will be randomly assigned to receive fecal microbiota transplantation only once or traditional therapy, and accept follow-up for at least one year. Blood tests,OGTT and magnetic resonance spectroscopy will be used to assess participants at study start and at study completion.

Official Title
-----------------
The Efficiency of Fecal Microbiota Transplantation on Type 2 Diabetes Mellitus

Conditions
-----------------
Efficiency, Methodology

Intervention / Treatment
-----------------
* Procedure: FMT through mid-gut


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Type 2 diabetes mellitus Exclusion Criteria: With any cause of liver disease other than fatty liver Known or suspected cirrhosis Inability or unwillingness to undergo OGTT and magnetic resonance procedures Requirement of long-term antibiotic therapy Pregnancy, breast-feeding, or plans to become pregnant

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: FMT by endoscopy<br>Once, fresh or frozen bacteria | Procedure: FMT through mid-gut<br> <br> * Other names: FMT through mid-gut by gastroscope;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The Efficiency of FMT on T2DM | Confirmed by the tests of blood glucose level, OGTT, HACb1 and C-peptide. | Up to 24 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Durability | Measure the durability of the therapy effects.Based on the tests of blood glucose level, HACb1 and C-peptide. BMI also will be observed. | Up to 12 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Gut bacteria, Bacteria, Fecal transplant, Bacteriotherapy