Bipolar Versus Monopolar Resection of Benign Prostate Hyperplasia

Study Overview
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Brief Summary
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Aim of this prospective clinical study was to compare two different surgical techniques and used solutions on serum electrolytes, bleeding and Transurethral Resection of Prostate (TURP) syndrome undergoing TURP. Fifty-three patients scheduled for elective TURP were enrolled in this prospective clinical study. Patients were included one of two groups (Group Monopolar and Group Bipolar).

Detailed Description
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Background and Purpose: Aim of this prospective clinical study was to compare two different surgical techniques and used solutions on serum electrolytes, bleeding and Transurethral Resection of Prostate (TURP) syndrome undergoing TURP. Methods: Fifty-three patients scheduled for elective TURP were enrolled in this prospective clinical study. Patients were divided into two groups. Patients in Group M (Monopolar) (n=25) were used monopolar resectoscope (Karl Storz, Tottling, Germany) and 5% mannitol as irrigating solution. Patients in Group B (Bipolar) (n=25) were used bipolar resectoscope TURis (OLYMPUS, Tokyo, Japan) and isotonic saline as irrigating solution. Patients who received spinal anaesthesia were given 2.5-3 ml 0.5% hyperbaric bupivacain intrathecally and others were given general anaesthesia. Patients demographics, prostate volumes, hemodynamic parameters, volumes of irrigation and IV solutions were recorded. Blood samples were collected preoperatively (control), 45 minutes after the induction (2nd Measurement) and 1 hour after the end of the operation for analyzing serum electrolytes, osmolarity, hemoglobin values.

Official Title
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Bipolar Versus Monopolar Resection of Benign Prostate Hyperplasia: A Comparison of the Effects on Plasma Electrolytes, Osmolarity and Hemoglobin

Conditions
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Acute Hyponatremia

Intervention / Treatment
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* Other: 5% Mannitol
* Other: 0,9% Sodium chloride
* Device: monopolar resectoscope
* Device: bipolar resectoscope TURis


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Men were older than 50 years Men suffered from symptomatic benign prostatic hyperplasia. Exclusion Criteria: History of severe heart failure History of respiratory failure History of bleeding diathesis

Ages Eligible for Study
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Minimum Age: 50 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Monopolar TURP<br>Patients in Group M (Monopolar) were used monopolar resectoscope (Karl Storz, Tottling, Germany) and 5% Mannitol as an irrigation fluid. | Other: 5% Mannitol<br>* Traditional monopolar TURP was performed by using and irrigation fluid containing 5% mannitol ( Resectisol Eczacibasi-Baxter).<br>* Other names: Karl Storz resectoscope;Device: monopolar resectoscope<br> <br> |
| Active Comparator: Bipolar TURP<br>Patients in Group B (Bipolar) were used bipolar resectoscope TURis (OLYMPUS, Tokyo, Japan) and 0,9% Sodium chloride as an irrigation fluid. | Other: 0,9% Sodium chloride<br>* Bipolar TURP was carried out by using a 24 Fr TURis (OLYMPUS) resectoscope and irrigation fluid containing 0,9 % sodium chloride.<br>* Other names: TURis (OLYMPUS) resectoscope;Device: bipolar resectoscope TURis<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum sodium level | Sodium level (meq /L) | 0-3 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Serum osmolarity | Osmolarity (mosm/kg) | 0-3 hours | 
| Serum potassium levels | Potassium level (meq/L) | 0-3 hours | 
| Serum hemoglobin level | Hemoglobin level (g /dL) | 0-3 hours | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Monopolar, Bipolar, TURP syndrome, hyponatremia