Exercise Tolerance in Patients With CABG and Sternotomy vs. Patients With Minimally Invasive Coronary Surgery

Study Overview
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Brief Summary
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In this study, up to 20 healthy individuals, 20 endo-ACAB patients, and 20 CABG patients undergo a maximal cardiopulmonary exercise test after hospital discharge (for patients only). Exercise tolerance is compared between groups.

Detailed Description
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In this prospective observational study, up to 20 healthy individuals (no history or presence of any chronic disease, sedentary), 20 endo-ACAB patients, and 20 CABG patients (matched for age, gender and BMI) undergo a maximal cardiopulmonary exercise test after hospital discharge (for patients only).During this exercise test, following parameters are assessed at peak effort and at the second ventilatory threshold (determined by VE/VCO2 slope method): oxygen uptake (VO2), oxygen saturation (SaO2), carbon dioxide output (VCO2), resoiratory gas exchange ratio (RER), expiratory volume (VE), ventilatory equivalent for VCO2 (VE/VCO2), ventilatory equivalent for VO2 (VE/VO2), end-tidal O2 pressure (PETO2), end-tidal CO2 pressure (PETCO2), heart rate (HR), oxygen pulse (VO2/HR), cycling power output (W), tidal volume (Vt), respiratory rate (RR), systolic blood pressure (SBP), diastolic blood pressure (DBP), rate pressure product (RPP). Peak exercise effort is validated by RERpeak.

Official Title
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Exercise Tolerance in Patients With Coronary Artery Bypass Surgery (CABG) and Sternotomy vs. Patients With Minimally Invasive Coronary Surgery

Conditions
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Coronary Artery Bypass Surgery

Intervention / Treatment
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* Other: Cardiopulmonary exercise test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: undergoing this type of surgery. For healthy subjects: must be sedentary. Exclusion Criteria: any neurologic, nephrologic, respiratory disease. For healthy subjects: any chronic disease or condition.

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| healthy individuals<br>Age, gender and BMI matched healthy subjects without any chronic disease or physical disability, and being sedentary. | Other: Cardiopulmonary exercise test<br>* Maximal exercise test with ergospirometry.<br>|
| CABG patients<br>Age, gender and BMI matched CABG patients, without neurologic, nephrologic, respiratory disease. | Other: Cardiopulmonary exercise test<br>* Maximal exercise test with ergospirometry.<br>|
| endo-ACAB patients<br>Age, gender and BMI matched endo-ACAB patients without neurologic, nephrologic, respiratory disease. | Other: Cardiopulmonary exercise test<br>* Maximal exercise test with ergospirometry.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| VO2peak (peak oxygen uptake) | Peak oxygen uptake capacity, expressed as ml/min. | At peak exercise, single measurement which is executed between 2-4 weeks after surgery. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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exercise tolerance