Efficacy of Movement Breaks in Real-World Settings

Study Overview
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Brief Summary
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The purpose of this study is to determine the efficacy of performing exercise snacks (short movement breaks throughout the day) on various measures of cardiometabolic health.

Detailed Description
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After being informed about the study and potential risks, all eligible participants who have provided consent will undergo a baseline visit to assess pre-intervention basic anthropometrics, cardiorespiratory fitness, and provide a blood sample. Participants will then be randomized in a 1:1 ratio to one of two groups: 1) Mobility movement breaks (stretching or range of motion exercises); or 2) Cardiovascular movement breaks (designed to raise heart rate). Both groups will be encouraged to perform 3-4 daily movement breaks on at least 3 days of the week with support from an online platform and app that provides video instructions and reminders to complete the movement breaks. After 12 weeks, participants will be asked to return to the lab for the same testing performed at baseline.

Official Title
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Efficacy of Movement Breaks in Real-World Settings

Conditions
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Healthy

Intervention / Treatment
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* Behavioral: Movement Breaks


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Physically inactive (performing <150 minutes of moderate-to-vigorous intensity aerobic exercise per week, assessed by pre-screening Get Active Questionnaire); Body Mass Index: 18.5-30.0 kg/m2; Not currently diagnosed with or being treated for cardiometabolic disease (e.g., coronary artery disease, diabetes); Not a current smoker; Cleared to engage in physical activity using the Get Active Questionnaire and, if applicable, consultation with a Qualified Exercise Professional; Access to a computer, tablet or smartphone for intervention delivery and tracking Exclusion Criteria: Chronic health condition preventing participation in exercise; Lack of access to internet connection

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 64 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Participants will be randomized (1:1 allocation ratio) into Mobility or Cardiovascular movement break groups for 12-weeks. Both groups will perform 3-4 movement breaks on at least 3 days of the week.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cardiovascular Movement Breaks<br>Participants will perform 3-4 exercise snacks (30-60s bursts of exercise) on at least 3 days of the week. The exercises prescribed in this arm will be designed to increase heart rate. | Behavioral: Movement Breaks<br>* Participants will be asked to perform 30-60 second movement breaks 3-4 times per day on at least 3 days per week.<br>* Other names: Activity Snacks;|
| Active Comparator: Mobility Movement Breaks<br>Participants will perform 3-4 mobility snacks (30-60s of mobility exercises or stretching) on at least 3 days of the week. The exercises prescribed in this arm are not designed to increase heart rate. | Behavioral: Movement Breaks<br>* Participants will be asked to perform 30-60 second movement breaks 3-4 times per day on at least 3 days per week.<br>* Other names: Activity Snacks;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from Baseline in Cardiorespiratory Fitness at 12 Weeks | Cardiorespiratory fitness will be assessed as the highest 30-s average from a laboratory-based graded VO2peak test on a cycle ergometer. | Baseline and Week 12 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from Baseline in Plasma Insulin | A fasted venous blood sample will be obtained and insulin measured by commercial assay. | Baseline and 12 weeks | 
| Change from Baseline in Plasma Glucose | A fasted venous blood sample will be obtained and glucose measured by biochemical assay. | Baseline and 12 weeks | 
| Change from Baseline in Insulin Resistance | A fasted venous blood sample will be obtained and insulin resistance estimated by homeostasis model assessment (HOMA) score | Baseline and 12 weeks | 
| Change from Baseline in Inflammatory cytokines | A fasted venous blood sample will be obtained and inflammatory cytokines measured by multiplex assay | Baseline and 12 weeks | 
| Change from Baseline in Body Mass | Body mass will be measured by weigh scale | Baseline and 12 weeks | 
| Change from Baseline in Waist Circumference | Waist circumference (in centimetres) will be measured using a measurement tape. | Baseline and 12 weeks | 
| Device-Measured Adherence to Movement Breaks | Participants will wear accelerometers to assess adherence near the beginning and the end of the intervention. | Week 2 and week 11 | 
| Self-Reported Adherence to Movement Breaks | Participants will be sent weekly surveys asking them to recall the total number of movement breaks performed that week. | Once per week for 12 weeks | 
| Movement Break Enjoyment assessed by the Exercise Enjoyment Scale (EES) | The EES is a validated, single-item 7-point scale to assess exercise enjoyment. Possible scores range from 1 (not at all) to 7 (extremely). | Immediately following each movement break for entire 12-week intervention | 
| Rating of Perceived Exertion (RPE) following Movement Breaks | A 10 point RPE scale will be used to assess perceived exertion ranging from 0 (rest) to 10 (maximal). | Immediately following each movement break for entire 12-week intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise Snack, Movement Break, Sedentary Time, Lifestyle Exercise, Physical Activity Breaks, VILPA