Breathing Performance of Healthy Young Adult

Study Overview
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Brief Summary
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The study will recruit subject of healthy adult, COPD-like patient and patient with COPD to investigate the difference of respiratory performance. We will measure the body composition, respiratory muscle force, pulmonary function and performance of voluntary cough. The muscle thickness of abdominal muscle and diaphragm, assessment of diaphragm during different breathing pattern and the muscle activation during voluntary cough will also being determined. We hypothesized that there will be a significantly different between three group on the performance of voluntary cough, and the correlation between each variable will be further investigated.

Detailed Description
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The specific aims of the study are: difference of respiratory muscle performance between three groups the correlation between respiratory symptom and pulmonary functional test difference of functional respiratory performance (peak cough flow of voluntary cough) between three groups muscle activation of abdominal muscle and diaphragm during performing voluntary force performance of diaphragm under different breathing load

Official Title
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Investigation of Breathing Performance of Healthy Young Adult

Conditions
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COPD, COPD-like

Participation Criteria
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Eligibility Criteria
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Health subject Inclusion Criteria: aged 20 years or above currently not being diagnosis as COPD less than 4 times/week of aerobic exercise COPD-like subject Inclusion Criteria: aged 20 years or above currently not being diagnosis as COPD presented of COPD symptoms (coughing, sputum production and dyspnea), last for 3 months and more than 2 years score more than 1 on modified Medical Research Council (mMRC) or COPD Assessment Test (CAT) COPD subject Inclusion Criteria: aged 20 years or above currently being diagnosis as COPD haven't participated in any pulmonary rehabilitation program in the past three months Exclusion Criteria: Untreated comorbidities for COPD Postural asymmetries (Scoliosis, length discrepancy of the lower limbs or other previous surgical history of spine) Chronic nonspecific lumbopelvic pain Gynecological or abdominal surgery in the previous year Pregnancy or post-delivery in the previous 6 months Neurological or inflammatory disorders Any conditions that may interfere with the data collection

Ages Eligible for Study
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Minimum Age: 20 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Health adult<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Peak cough flow | Peak coughing velocity of voluntary cough in liter/second | baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Respiratory muscle force | MIP/MEP in cmH2O | baseline | 
| Pulmonary function test | PEF/MVV in liter/min | baseline | 
| Pulmonary function test | FEV1/FVC/VT in liter | baseline | 
| Pulmonary function test | MVV rate in breaths/min | baseline | 
| Muscle thickness during voluntary force | tRA/tEO/tIO/tTrA/tD in millimeter | baseline | 
| Muscle activation during voluntary force | aURA/aLRA/aEO/aIOTrA/aD (all the data will be collected through surface EMG and will be presented as maximal voluntary contraction in %) | baseline | 
| Diaphragm assessment | QB_ex/DB_ex/Sniff_ex in millimeter | baseline | 
| Diaphragm assessment | QB_slope/DB_slope/Sniff_slope in cm/s | baseline | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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COPD, Diaphragm, Voluntary cough, Abdominal muscle activation