Follow-up During the Peripubertal Period of Preterm Children Included in the Protocol Entitled EPIPOD.

Study Overview
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Brief Summary
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Prematurity is associated with an increased risk of developing cardiovascular and metabolic disturbances in adulthood. It has been demonstrated that the body composition of children born prematurely is different from that of children born under term with a deficit in fat free mass. It can thus be wondered if this excessive adiposity does or does not predict the risk of insulin resistance in adulthood. Children born prematurely, with a body composition measurement performed at discharge from neonatal hospitalization as part of the EPIPOD protocol, and now aged between 8 and 14 years, will be included in the INFANTPOD protocol. Analysis of body composition, insulin resistance, renal function, pulse wave velocity, eating behaviour and of neuropsychological development will be performed.

Official Title
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Follow-up During the Peripubertal Period of Preterm Children (Under 35 Weeks of Amenorrhea) Included in the EPIPOD Protocol : Evaluation of Insulin Resistance and of Neuropsychological Development

Conditions
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Preterm Children

Intervention / Treatment
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* Other: clinical and biological measurements and questionnaires


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Children hospitalised at the Nantes University Hospital in the neonatal period With a body composition measurement performed at discharge from neonatal hospitalization as part of the EPIPOD protocol Born prematurely (under 35 weeks of amenorrhea) Included in the Lift cohort with follow-up up to 7 years Aged between 8 and 14 years at inclusion Exclusion Criteria: Children with an isolated metabolic disease: insulin-dependent diabetes; endocrine disease (Cushing's, hypothyroidism) Age of 15 years or more with a chromosomal anomaly with contraindicating measurement of the BOP-POD: ventilatory support, continuous parenteral feeding, elimination stoma Refusal of either parent or child

Ages Eligible for Study
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Minimum Age: 8 Years
Maximum Age: 14 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Children born prematurely included in the EPIPOD protocol and now in the peripubertal period<br>At inclusion in the INFANTPOD study : Blood and urinary samples collection for evaluation of insulin resistance and of renal function analysis. Assessment of body composition by a commercialized device called BOP-POD and by impedancemetry Assessment of pulse wave by a commercialized device called popmetre Questionnaires for analysis of eating behaviour and of neuropsychological development. | Other: clinical and biological measurements and questionnaires<br>* Blood and urinary samples collection for evaluation of insulin resistance and of renal function analysis. Assessment of body composition by BOP-POD and by impedancemetry. Assessment of pulse wave by popmetre. Questionnaires for analysis of eating behaviour and of neuropsychological development.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin resistance as measured by the Triglyceride-Glucose Index |  | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Insulin resistance as measured by the Homeostasis Model Assessment - Insulin Resistance index |  | 1 day | 
| Body composition (percentage of fat versus fat free mass) by BOP-POD and by impedancemetry (biodyXpert) for assessment of body composition variations between peripubertal period and neonatal period |  | 1 day | 
| creatinine clearance |  | 1 day | 
| Eating behaviour using standardized questionnaire named Child Eating Behaviour questionnaire |  | 1 day | 
| Eating behaviour using standardized french questionnaire named QCAJE Questionnaire Comportement Alimentaire du Jeune Enfant |  | 1 day |