TIVA Versus Desfluran Anaesthesia in Patients Undergoing Bariatric Surgery

Study Overview
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Brief Summary
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Many factors during laparascopic surgery leads to PONV (postoperative nausea and vomiting), such as C02 insufflations causing peritoneal stretch and irritation and type of anaesthesia given during surgery. The two anesthetic techniques used in bariatric surgery are gas anesthesia (Remifentanil TCI and Desfluran) and Total Intra Venous Anesthesia (TIVA) with propofol. There are studies which have shown a reduction in postoperative nausea and vomiting following TIVA, and there are publications showing no statistically significant difference. The aim of this study was to investigate the best anaesthetic approach for obese subjects, evaluating awakening time, postoperative nausea and pain. Our hypothesis was based on the fact that Propofol is a lipid-soluble anesthetic and therefore might have a prolonged effect in obese patients, leading to a longer awakening time along with postoperative nausea and vomiting. This hypothesis is also described earlier by obese patients have more depots (bulk fat) and also more fat surface making anaesthetics storage more easier, and also that the anesthetic will return into the circulation when the administration is stopped [18].

Official Title
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A Randomized Controlled Trial - Total Intravenous Anaesthesia Versus Inhaled Desfluran Anaesthesia in Patients Undergoing Bariatric Surgery. Postoperative Pain and Nausea

Conditions
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Desflurane, Total Intravenous Anesthesia, Obesity, Pain, Postoperative, Nausea, Postoperative

Intervention / Treatment
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* Drug: Desflurane


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI ≥35 kg/m2 with at least one comorbid condition or BMI ≥40 kg/m2. Exclusion Criteria: drug abuse severe mental illness age<18 serious medical condition; cancer, end-stage lung disease (ASA>3) or allergies to any drugs used in the study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: randomized control trial.
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Gass<br>DESFLURANE ANESTHESIA | Drug: Desflurane<br>* Desflurane vs TIVA, bariatric surgery. Postoperative nausea and pain<br>* Other names: PROPOFOL;|
| Active Comparator: TIVA<br>TOTAL INTRAVENOUS ANESTHESIA | Drug: Desflurane<br>* Desflurane vs TIVA, bariatric surgery. Postoperative nausea and pain<br>* Other names: PROPOFOL;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Awakening time after surgery | time noted from anaesthesia stoped to patients awake | 2 hours postdose | 
| Degree of nausea and vomiting after surgery | Noted using NRS scale (from 0-10) | 48 hours postsurgery | 
| Degree of pain after surgery | Noted using NRS scale (from 0-10) | 48 hours post surgery |