Does the Use of Hemostatic Clips During the Tumor Resection Step Reduce Blood Loss During Robot-assisted Partial Nephrectomy?

Study Overview
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Brief Summary
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One challenge of robot-assisted partial nephrectomy (RAPN) is to reduce operative blood loss. Partial nephrectomy (PN) is a complex surgery that is being made easier by robotic assistance. In this study, we determined whether the use of hemostatic clips during the tumor resection step reduced blood loss during robot-assisted partial nephrectomy. Methods: In this retrospective study, we included all consecutive patients who underwent RAPN in our university hospital from 2017 to 2019. Three experienced surgeons performed the surgery. One surgeon used Hemo-lock hemostatic clips during tumor resection to prevent bleeding, and two did not. Blood loss in the two groups was compared as the primary endpoint. The duration of clamping, operative time, complications, surgical margins, transfusions, serum creatinine and hemoglobin were compared as secondary endpoints. Results: 53 patients were included, 36 in the No-clip group and 17 in the Clip group. Our two groups were comparable for age, weight, Charlson score, tumor size and RENAL score. There was a significant difference between the two groups for median blood loss 50 mL in the Clip group versus 300 mL in the No-clip group (p = 0.0001), whereas median operating time was shorter in the No-clip group, 140 min versus 180 min for the Clip group (p = 0.044). No other criterion showed a significant difference. The use of Hemo-lock during the tumor resection step in RAPN reduced blood loss without impairing renal function. Larger studies are still needed to confirm our findings.

Official Title
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Does the Use of Hemostatic Clips During the Tumor Resection Step Reduce Blood Loss During Robot-assisted Partial Nephrectomy?

Conditions
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Renal Cancer, Kidney Cancer, Blood Loss

Intervention / Treatment
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* Procedure: Patial nephrectomy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: all consecutive patients who underwent Robot Assisted Partial Nephrectomy Exclusion Criteria: patient off clamping or partial clamping

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Clip Group<br>Use of Hemo-lock hemostatic clips during tumor resection to prevent bleeding | Procedure: Patial nephrectomy<br>* Partial nephrectomy assisted with robot to remove kidney cancer<br>|
| No Clip group<br>No Hemo-lock hemostatic clips used during tumor resection | Procedure: Patial nephrectomy<br>* Partial nephrectomy assisted with robot to remove kidney cancer<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood loss in the two groups was compared | It was mesured during the surgery by amount of blood drawn | 3 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| operative time | duration from the begining to the end of the surgery | 3 years | 
| duration of clamping | time between the clips set and remove during the surgery for patient of clip group | 3 years | 
| incidence of complications | rate of complication after surgery | 3 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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robot assisted partial nephrectomy, tips