Effectiveness and Neuropsychological Predictors of Guided Self-Help for Obsessive-Compulsive Disorder (OCD)

Study Overview
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Brief Summary
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The primary aim of this study is to learn about who is most likely to benefit from guided self-help (GSH) for obsessive-compulsive disorder (OCD).

Detailed Description
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40 Participants with OCD will be recruited. They will be given access to OC Fighter, an internet OCD treatment program. During the 17 week program, participants will meet with a therapist 9 times. Assessments will occur at pretreatment, post-treatment, 3-month follow up and 6-month follow up.

Official Title
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Effectiveness and Neuropsychological Predictors of Guided Self-Help for OCD

Conditions
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Obsessive-Compulsive Disorder

Intervention / Treatment
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* Behavioral: OCFighter


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Principal or co-principal diagnosis of OCD Clinical global impression score greater than or equal to 4 Y-BOCS score great than or equal to 8 Fluency in English Capacity to understand the nature of the study and willingness to sign informed consent form Exclusion Criteria: Active manic episode, psychosis, pervasive developmental disorder, mental retardation Concurrent OCD psychotherapy Current threat of harm to self or others Previous adequate trial of therapist-administered or self-administered exposure and response prevention for OCD

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 69 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: OCFighter<br>OCFighter | Behavioral: OCFighter<br>* OCFighter™ s an interactive, internet guided self-help (GSH) treatment program for obsessive-compulsive disorder (OCD). It uses the evidence based approach known as Cognitive Behavioral Therapy (CBT) and was adapted from the previously validated BT STEPS program for OCD. The program teaches the best practice CBT technique to help with OCD called exposure with ritual prevention (ERP).<br>* Other names: Guided Self-help;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) | The Y-BOCS is a semi-structured interview that assesses severity of obsessions and compulsions. The total score is reported here and ranges from 0 to 40 with higher scores indicating more severe OCD symptoms. | Baseline (pretreatment), 17-weeks (posttreatment), and 6 month-follow-up | 
| Responder Status | Participants who experienced a clinically significant change in Y-BOCS score defined as posttreatment YBOCS score that (a) has decreased by a reliable level (at least 1.96 times the standard deviation of that measure, taking into account the reliability of the measure itself; in this case, a decrease of 5 points or more), and (b) is within the nonclinical range of scores (in this case, a score of 13 or below). | Week 17 (post-treatment) and 6-month follow-up |