Effect of Intravenous Infusion of Lidocaine on Patients Undergoing Radical Resection of Colorectal Tumors

Study Overview
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Brief Summary
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Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Surgical resection is the main treatment option for colorectal cancer patients. Surgery may enhance or accelerate tumor recurrence and metastasis. Multiple factors in the tumor microenvironment play important roles in tumor recurrence and metastasis, and modulating the tumor microenvironment can inhibit disease progression. Lidocaine has been found to inhibit tumor growth in animal experiments.

Detailed Description
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Lidocaine was applied in the operation of colorectal tumor patients, and the effect on the postoperative microenvironment and micrometastasis of the patients was observed by detecting the stress, immunity, vascular tumor regeneration, inflammation, etc. of the patients.

Official Title
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Effect of Intravenous Infusion of Lidocaine on Patients Undergoing Radical Resection of Colorectal Tumors

Conditions
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Colorectal Tumors, Lidocaine

Intervention / Treatment
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* Drug: Administer 1.5 mg/kg intravenously to the patient before induction of anesthesia, and continue to infuse 1.5 mg/kg/h during the operation until the end of the operation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: colorectal tumor patients Exclusion Criteria: Weight <45kg and >100kg Sensitivity or hypersensitivity to lidocaine Second or third degree heart block Severe heart failure (ejection fraction < 20%) History of active rhythm disorder Acute severe liver and kidney injury History of uncontrolled seizures History of acute porphyria.

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Lidocaine is used in radical resection of colorectal tumors.<br>Administer 1.5 mg/kg intravenously to the patient before induction of anesthesia, and continue to infuse 1.5 mg/kg/h during the operation until the end of the operation | Drug: Administer 1.5 mg/kg intravenously to the patient before induction of anesthesia, and continue to infuse 1.5 mg/kg/h during the operation until the end of the operation<br>* Administer 1.5 mg/kg lidocaine<br>* Other names: same volume of saline;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the concentration of tumor micrometastasis markers were determined by ELISA | the concentration of tumor micrometastasis markers such as CK20 was determined by ELISA | 3 days after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the concentration of stress hormones were determined by ELISA | the concentration of EPI and NE were determined by ELISA | 3 days after surgery | 
| the concentration of inflammatory factor were determined by ELISA | the concentration of IL-6,IL-8,TNF-α were determined by ELISA | 3 days after surgery | 
| the concentration of angiogenesis factors were determined by ELISA | the concentration of VEGF was determined by ELISA | 3 days after surgery | 
| the concentration of immune indexes were determined by ELISA | the concentration of B lymphocytes, T lymphocytes, NK cells, macrophages were determined by ELISA | 3 days after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Radical resection of colorectal tumor, lidocaine, stress, immunity, vascular tumor regeneration, inflammation, micrometastasis