A Custom-Designed MR Coil for Spine Radiotherapy Treatment Planning

Study Overview
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Brief Summary
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The purpose of this study is to assess the image quality improvement provided by a custom MR spine coil in comparison with the FDA approved coil when used for radiotherapy treatment planning.

Official Title
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A Custom-Designed MR Coil for Spine Radiotherapy Treatment Planning

Conditions
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Healthy

Intervention / Treatment
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* Diagnostic Test: Custom Designed Spine Coil
* Diagnostic Test: FDA approved spine coil


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy Volunteers age 18 or older Exclusion Criteria: Anyone who would be normally excluded from undergoing an MRI examination as per Memorial Hospital for Cancer and Allied Diseases Screening Questionnaire Volunteers with a pacemaker, aneurysm clip or any other condition that would warrant avoidance of a strong magnetic field Female volunteers who are pregnant or nursing Volunteers who are unable to comply or complete the MRI exam due to claustrophobia or high levels of anxiety Volunteers who are under direct supervision of any investigators on the study will not be eligible to participate

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Custom MR spine coil<br> | Diagnostic Test: Custom Designed Spine Coil<br>* During the participant's MR scan, the custom spine coil will be placed between the participant and the immobilization mold. image parameters will be optimized for spine anatomy for the pulse sequences which are standard for MR imaging.<br>Diagnostic Test: FDA approved spine coil<br>* During the participant's MR scan, the FDA spine coil will be placed between the participant and the immobilization mold. image parameters will be optimized for spine anatomy for the pulse sequences which are standard for MR imaging. Volunteers may receive up to 3 scans to allow for comparisons of changes to the calibration files as we continue to test the coil and improve its performance.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Optimize performance | Optimize performance of custom-designed spine coil in RT configuration on participants. This objective focuses on the technology of the custom designed spine coil and does not require any statistical analysis. | Day of intervention | 
| Compare the signal-to-noise ratio of a custom spine coil with the existing FDA approved posterior coil array used for spine imaging | To quantify image quality obtained from the custom spine coil and the existing coil, SNR will be calculated (see Section 4.1 for details) for both coils. If, for a volunteer, the SNR from the custom coil is larger than 105% of that from the existing coil (we insist a 5% improvement margin due to anticipated uncertainty and variability), then we will classify this sample point as a success. We will combine the 15 volunteers from the three cohorts (cervical-spine, thoracic-spine and lumbar-spine) and impose the following decision rule: If at least 12 out of the total 15 volunteers are success, then we declare the custom designed spine coil promising and worthy of further investigation. | Day of intervention | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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MRI, MR imaging, 17-267