Cryopreserved Human Meniscus Transplantation

Study Overview
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Brief Summary
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The purpose of this study is to determine the long-term survivorship and clinical outcomes of all cryopreserved meniscus transplants performed by Dr. Frank Noyes.

Detailed Description
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All patients receiving cryopreserved meniscus transplants will be followed at 1, 2, 5, 10, and 15 years postoperatively. Study examination will include comprehensive knee examination by Dr. Noyes, x-rays, and potentially MRI. Patients will complete the following forms of the Cincinnati Knee Rating System: Symptom Rating Form, Sports Activity and Function Form, and Occupational Rating Form. All patient identification will be kept confidential. Patient data will be entered into the Knee Registry database according to their unique study number by the clinical research assistant.

Official Title
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Meniscus Transplantation in Symptomatic Patients Under Fifty Years of Age: Survivorship Analysis

Conditions
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Osteoarthritis

Intervention / Treatment
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* Procedure: Cryopreserved meniscus transplants


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient post-meniscectomy Patient symptomatic with activities Patient has early articular cartilage degeneration in affected tibiofemoral compartment Patient understands goals of operation, willing to undergo lengthy rehabilitation Exclusion Criteria: Patient has no symptoms with activities Patient has advanced degeneration in affected tibiofemoral compartment or other compartments Patient is obese (BMI > 30) Patient has uncorrected lower limb axial malalignment or knee ligament deficiency Patient has active infection Patient has pre-existing knee arthrofibrosis or lower limb muscular atrophy Patient has symptomatic patellofemoral articular cartilage deterioration Patient is unwilling to undergo lengthy rehabilitation after surgery

Ages Eligible for Study
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Minimum Age: 14 Years
Maximum Age: 49 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cryopreserved meniscus transplant<br>Intervention: Lateral or medial cryopreserved meniscus transplant implanted into appropriately indicated patients. | Procedure: Cryopreserved meniscus transplants<br>* Lateral or medial cryopreserved meniscus transplants implanted into appropriately indicated patients.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survivorship analysis |  | 15 years postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cincinnati Knee Rating System | The following factors will be scored according to the validated Cincinnati Knee Rating System: pain, swelling, giving-way, walking, stair-climbing, squatting, running, jumping, pivoting, sports activity level, occupational level, patient perception of the knee condition. | 15 years postoperatively | 
| International Knee Documentations Committee | The validated IKDC overall evaluation form will be used to rate knee function. | 15 years postoperatively |