Demineralized Dentin Graft With Hydrochloric Acid Versus Nitric Acid in Alveolar Ridge Preservation

Study Overview
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Brief Summary
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The reduction in alveolar bone dimensions is an inevitable outcome after tooth extraction due to the healing events that results in bone modeling/remodeling. Alveolar ridge preservation is a successful approach that aids in reducing these changes greatly. Various techniques have been employed to achieve that outcome utilizing bone grafts and/or membrane. Dentin graft is a promising type that can overcome many of the limitations facing mainstream grafts. Autogenous source serve the advantage of providing graft with no cross-infection risk or immunogenicity. Moreover, the unique structure of dentin makes it suitable for osteoinduction and osteoconduction that yields favorite bone regeneration outcomes. Demineralization of dentin is essential to release trapped growth factors, expose collagen fibrils and enhance the grafts degradability and replacement by native tissues. Many acids have been investigated for the use in chairside preparation of the dentin graft and hence, clinicians are faced with different choices but little evidence regarding the acid which yield s better outcomes.

Official Title
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Demineralized Dentin Graft With Hydrochloric Acid Versus Nitric Acid in Alveolar Ridge Preservation. Randomised Controlled Clinical Trial

Conditions
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Alveolar Bone Loss

Intervention / Treatment
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* Procedure: Alveolar ridge preservation after extraction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Non-restorable teeth medically healthy able to provide informed consent and attend follow-up period Exclusion Criteria: pregnant smokers or alcoholic severe bone loss

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Interventional Model Description: Split-mouth prospective randomized clinical trial with 1:1 assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: autogenous dentin graft treated with nitric acid<br> | Procedure: Alveolar ridge preservation after extraction<br>* atraumatic extraction followed by graft material insertion<br>|
| Active Comparator: autogenous dentin graft treated with hydrochloric acid<br> | Procedure: Alveolar ridge preservation after extraction<br>* atraumatic extraction followed by graft material insertion<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Radiographic bone changes | width and height losses (quantitative in mm) | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| histological analysis | Histologic observations (qualitative) and histomorphometric measurements (quantitative in %) | 6 months | 
| soft tissue healing | rate of wound epitheliallization | Biweekly for 6 weeks |