linjc16/ctgov huggingface dataset:
Effects of Pulsed-Dyed Laser on Scar Formation

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to identify changes in color, thickness, and stiffness, of scars from skin grafting after burns when treated with a pulsed-dyed laser.

Detailed Description
-----------------
Pulsed-dyed lasers have been used in the past to treat scars from minor surgery as well as burns. The laser has been used at different times, close to injury or late after injury. Success or failure of the laser has been judged by subjective observer scales. In this study we will treat the seams of 1/2 of a skin graft with a pulsed-dyed laser, beginning about one month after surgery. We will use objective measures of color (redness on digital pictures), scar volume(via laser scanning), and elasticity(measured by BTC-2000) as well as subjective assessment by an independent observer and the patient.

Official Title
-----------------
Effects of Pulsed-Dyed Laser on Scar Formation

Conditions
-----------------
Scars

Intervention / Treatment
-----------------
* Device: Treatment of 1/2 of skin graft with pulsed-dye laser


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: > 9 years old not pregnant new skin graft to extremity able to follow simple instructions Exclusion Criteria: age less than 9 years pregnancy any behavior pattern that would lead to conclusion that patient may not reliably follow simple instructions

Ages Eligible for Study
-----------------
Minimum Age: 9 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Treatment of 1/2 of skin graft with pulsed-dye laser|Pulsed-dye laser will be applied to 1/2 of the seam of the skin graft, using a 10mm spot size, and sufficient pulse-width and fluency to induce purpura.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Amount of redness of scar |  | 4 to 12 months after skin grafting | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Scar height |  | 4-12 months after skin grafting | 
| Scar stiffness |  | 4-12 months after skin grafting | 
| Patient's assessment of cosmetic outcome |  | 4-12months after skin grafting | 
| Clinical improvement of appearance of scars assessed by subjective scale |  | 4-12 months after skin grafting | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
scars, late effect of burn, burn, pulsed-dye laser
Phone Intervention for Alcohol (ETOH) Use in Emergency Department Motor Vehicle Crash (ED MVC) Patients

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine if a brief counseling intervention, delivered by telephone, is more effective than standard ED care, to reduce future alcohol related injuries and alcohol related negative consequences, among patients treated in the ED for injuries from an MVC and other injury mechanisms.

Detailed Description
-----------------
Alcohol related motor vehicle crashes (MVC) continue to be a substantial public health problem. Brief interventions for alcohol (BI) for injured ED patients have been demonstrated to be effective, and perhaps more so for MVC patients. Telephone interventions have been utilized in varying ways in health care. We compared the delivery of two brief interventions by telephone against an assessment only condition. Participants who received the BI and the assessment only condition were contacted 3 and 12 months after recruitment. Data about alcohol use, injuries and high risk behaviors, including drinking and driving behaviors were collected at the 3 and 12 month follow-up assessments.

Official Title
-----------------
Study of Effectiveness of BI Given to Injured MVC ED Patients Who Use Alcohol Harmfully and Hazardously

Conditions
-----------------
Alcoholic Intoxication, Wounds and Injuries

Intervention / Treatment
-----------------
* Behavioral: Brief Telephone Counseling for risky aclohol use


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 18 years or older Emergency department patient Subacute injury Motor vehicle crash or other injury Alcohol use at harmful and hazardous levels Exclusion Criteria: Younger than 18 years old Does not meet alcohol use criteria Non-English speaker In police custody Suicidal Psychiatric diagnosis No locator Injury occurred > 72 hours prior to ED visit

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: Brief Telephone Counseling for risky aclohol use|Two brief sessions (30-40 minutes) of brief counseling using a motivational interviewing approach. The counseling session are delivered by telephone and focus on the alcohol use of inuured ED patients who randomize into the treatment arm of the study. Patient who randomize into the controla rm of the study receive standard emergency department care only plus study assessments.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Alcohol use, Brief Interventions, Injuries, Emergency Department Patients, Harmful and hazardous alcohol use among ED injured patients
Sodium Bicarbonate for Prevention of Contrast-Induced Nephropathy

Study Overview
=================
Brief Summary
-----------------
The purpose of this study is to determine whether hydration with sodium bicarbonate is superior to hydration with saline to prevent contrast-induced nephropathy.

Official Title
-----------------
Hydration With Sodium Bicarbonate for Prevention of Contrast-Induced Nephropathy: A Multicenter Clinical Trial

Conditions
-----------------
Renal Failure

Intervention / Treatment
-----------------
* Drug: sodium bicarbonate
* Drug: saline


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: serum creatinine > 1.1 mg/dL glomerular filtration rate (GFR) < 50 mL/min Exclusion Criteria: age < 18 years use of radiographic contrast media during the last 21 days history of dialysis cardiac insufficiency class III-IV emergency procedures

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: sodium bicarbonate<br>hydration with sodium bicarbonate | Drug: sodium bicarbonate<br>* hydration with sodium bicarbonate 1ml/Kg/h for 6 hours<br>|
| Active Comparator: saline<br>hydration with saline 1ml/Kg/h for 6 hours | Drug: saline<br>* hydration with saline 1ml/Kg/h for 6 hours<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Contrast-induced Nephropathy | rise in serum creatinine >0,5mg/dl | 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dialysis During Hospitalization |  | During hospitalization | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
contras-induced nephropathy
Muscle Strength and Inflammatory Response in Patients With Inclusion Body Myositis

Study Overview
=================
Brief Summary
-----------------
Comparison of a group of 20 IBM patients with 20 controls matched on age, gender and weight.

Official Title
-----------------
Evaluation of Muscle Strength and Inflammatory Response in Patients With Inclusion Body Myositis

Conditions
-----------------
Inclusion Body Myositis

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Age > 18 years old Written consent Exclusion Criteria: Current infection Cancer within 1 year Immune deficiency

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Inclusion Body Myositis<br> | |
| Control<br> | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| muscle strength |  | 2 evaluations at an interval of 9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| immune response |  | 1 measure at inclusion |
Feasibility of Opportunistic Salpingectomy at the Time of Vaginal Hysterectomy for Benign Pathology

Study Overview
=================
Brief Summary
-----------------
In this prospective study, patients who underwent vaginal hysterectomy with salpingectomy or salpingo-oophorectomy were included. The objective of this study is to assess the feasibility of prophylactic salpingectomy during vaginal hysterectomy for benign pathology and the prevalence of occult tubal lesions. The hypothesis is that prophylactic salpingectomy during vaginal hysterectomy for benign pathology present a low failure rate and it makes it possible to avoid the appearance of a certain number of ovarian cancers. The prevalence of bilateral salpingectomy with or without ovariectomy and the prevalence of histopathological and immunohistochemical (p53 expression) abnormalities were evaluated.

Official Title
-----------------
Feasibility of Opportunistic Salpingectomy at the Time of Vaginal Hysterectomy for Benign Pathology and Evaluation of Occult Tubal Lesions Prevalence: Preliminary Study

Conditions
-----------------
Salpingectomy, Hysterectomy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients who underwent vaginal hysterectomy for benign pathology with salpingectomy or salpingo-oophorectomy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Success rate of the surgical technique | prevalence of bilateral salpingectomy with or without ovariectomy | Day 0 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
prophylactic salpingectomy, vaginal hysterectomy, p53 expression, ovarian cancers
Continuous Local Anesthesia Versus Continuous Femoral Nerve Bloc After Total Knee Arthroplasty: Impact on Mean Discharge Aptitude Delay

Study Overview
=================
Brief Summary
-----------------
This study aims at comparing continuous local anesthesia and femoral nerve bloc for total knee arthroplasty in terms of post-operative recovery.

Official Title
-----------------
Continuous Local Anesthesia Versus Continuous Femoral Nerve Bloc After Total Knee Arthroplasty: Impact on Mean Discharge Aptitude Delay

Conditions
-----------------
Total Knee Arthroplasty

Intervention / Treatment
-----------------
* Drug: Ropivacaine


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Total knee arthroplasty Age > 18 years with social security covering. Written informed consent Exclusion Criteria: Age < 18 years ASA Physical Status > III Body weight < 50 kg Latex or silver allergy. Loco-regional anesthesia contraindication Chronic anticoagulant, corticoid or pain treatment. Rivaroxaban or enoxaparin contraindication Communication issues Patient under guardianship Pregnant or breast-feeding patient

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Continuous femoral nerve bloc<br>Continuous femoral nerve bloc | Drug: Ropivacaine<br> <br> |
| Experimental: Continuous local anesthesia<br>Continuous local infiltration of local anesthetic in the operated knee. | Drug: Ropivacaine<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Discharge ability time period |  | Participants will be followed for the duration of hospital stay, an expected average of 10 days |
Conjoined Twins: a Report of Four Cases.

Study Overview
=================
Brief Summary
-----------------
The present study aims to report our experience in conjoined twin separation surgery in Assuit university and pediatric hospital, Assiut university, Assiut, Egypt over a period of 20 years.

Detailed Description
-----------------
A conjoined twin is a subset of monozygotic twin gestation. It's a rare phenomenon with an incidence of 1 in 50,000 to 1:100,000 births with the higher incidence in Africa and Southwest Asia. Based on the terminology proposed by Spencer and colleagues, conjoined twins are classified according to the most prominent site of conjunction into three major groups; First, twins with a ventral union; [cephalopagus (head), thoracopagus (Thorax), omphalopagus (Abdomen) and ischiopagus (pelvis)]. Second; twins with a dorsal union; [pygopagus (sacrum), rachipagus (spine, back) and craniopagus (cranium)] and lastly; twins with a lateral union that is referred to as parapagus (side). Depending on the aspect of the embryonic disc, the most common types are thoracopagus (19%). Surgical separation of conjoined twins is extremely challenging taking in consideration the high perioperative risk. The low incidence of such surgeries and anatomical variations in each type of conjoined twins makes each separation surgery a unique experience.

Official Title
-----------------
Conjoined Twins: a Report of Four Cases.

Conditions
-----------------
Conjoined Twin

Intervention / Treatment
-----------------
* Procedure: Conjoined twin separation surgery


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: conjoined twins symmetrical or asymmetrical. Exclusion Criteria: conjoined twins incompatible with life conjoined twins with decapitating medical illness.
Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Conjoined twin separation surgery|This study included 4 case reports on conjoined twins (CT), 2 male and three female patients; 3 of them were parasitic and one was conjoined. We operated upon 2 parasitic and one conjoined. The 1st case died preoperatively.|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Success of the conjoined twin separation surgery | The operative details of the separation surgery were written in details and the separation process was showen in pictures. | For each case was the 1 week survival |
Modified Environment for Agitation in Patients With TBI

Study Overview
=================
Brief Summary
-----------------
This study examines the effect of an intervention consisting of dynamic circadian light and sound therapy, as well as systematic information on sleep pattern, agitated behavior and functioning level.

Official Title
-----------------
Modified Environment for Agitation in Patients With Traumatic Brain Injury: a Controlled Multicenter

Conditions
-----------------
Agitated Behaviour, Traumatic Brain Injury (TBI)

Intervention / Treatment
-----------------
* Behavioral: Multifactorial circadian concept


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients with moderate and severe Traumatic Brain Injury (TBI) Diagnosed with Glasgow Coma Score (GCS) lower than 13- Exclusion Criteria: Patients with psychiatric diagnose and not speaking danish -

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Intervention<br>Intervention: Circadian lighting, systematic information, music, foreclosure of the individual patient | Behavioral: Multifactorial circadian concept<br>* Circadian light, systematic information, music, individual foreclosure<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Agitation on Agitated Behaviour Scale (ABS) |  | One year | 
| Functional abilities on the Early Functional Abilities Scale (EFA) |  | One year | 
| Functional abilities on the Glasgow Outcome Extend Scale |  | 12 month after admission | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Orientation and duration of post-traumatic amnesia on the Galveston Orientation and Amnesia Scale (GOAT) |  | One year |
French Adaptation of the California Card Sorting Task (CCST) in Multiple Sclerosis

Study Overview
=================
Brief Summary
-----------------
Cognitive impairment affects up to 65% of multiple sclerosis (MS) subjects, especially executive functions. The California Card Sorting Task (CCST) assesses specific components of problem-solving ability. There is currently no French version of this test. Reims neurological department in collaboration with Rothschild Foundation has developed a French adaptation of CCST. This version includes three cards packages with two alternate forms to control practice effects (test-retest). In order to assess test-retest reliability we have to verify the comparability of the three cards packages within one session in MS patients.

Official Title
-----------------
French Adaptation of the CCST (California Card Sorting Task). Comparison of 3 Packages to CCST With Multiple Sclerosis (MS) Patients

Conditions
-----------------
Multiple Sclerosis

Intervention / Treatment
-----------------
* Other: assessment of problem-solving ability


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Multiple Sclerosis patients age > 18 years old Exclusion Criteria: Montreal Cognitive Assessment (MOCA) ≤20 psychiatric disease no proficiency in the French language opposition to participate in the study no medical insurance coverage

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: assessment of problem-solving ability|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CCST Test score | comparison of the scores of the three versions of the test | baseline |
Pathology Analysis of OPMD Patient Myotomies

Study Overview
=================
Brief Summary
-----------------
The study aims to characterize the effect of OPMD mutation on muscle function. Muscle samples will be received from oculopharyngeal muscular dystrophy (OPMD) patients who undergo cricopharyngeal muscle-cutting surgery, as part of their routine healthcare and treatment.

Official Title
-----------------
Pathology Analysis of OPMD Patient Myotomies

Conditions
-----------------
Oculopharyngeal Muscular Dystrophy

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: OPMD patients both male and female. OPMD patients between the ages 18-70 years. OPMD patients who are referred to the cricopharyngeal muscle-cutting surgery as part of their usual treatment. Exclusion Criteria: • OPMD patients not referred to the cricopharyngeal muscle-cutting surgery as part of their usual treatment.

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of genes that show changes in RNA profile, measured by sequencing. | RNA profile analysis of OPMD muscle samples will be compared to unaffected muscle samples using sequencing to identify gene numbers. | Data will be collected within four years. | 
| Number of genes that show changes in protein profile, measured by SDS page. | Protein profile analysis of OPMD muscle samples will be compared to unaffected muscle samples to identify gene numbers using SDS page. | Data will be collected within four years. |