Evaluation of the Effect of Endoscopic Urethral Procedures Applied After Radical Prostatectomy on Urinary Incontinence

Study Overview
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Brief Summary
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The researchers investigated whether endoscopic retrograde urethral interventions applied for various reasons after radical prostatectomy (RP) operation cause a change in urinary incontinence (UI) level, and if there is a change, whether it changes according to the endoscopic procedure time and the endoscopic instrument used.

Detailed Description
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Localized prostate cancer is usually treated with RP. The most common complications after RP are erectile dysfunction (ED) and UI. After RP, some patients may require retrograde endoscopic urethral intervention. In this study, researchers investigated whether there is a change in the UI level in patients that underwent retrograde urethral intervention after RP and whether this change was affected by the duration of the procedure and type of endoscopic device used. Methods: Eighteen patients were included in the study. The patients were divided into 3 groups based on the endoscopic device used: group 1 rigid cystoscopy, group 2 flexible cystoscopy, and group 3 semi-rigid ureterorenoscopy (URS). The Turkish version of the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-SF) and the number of pads used daily was questioned before the endoscopic procedure and 1 month after the procedure.

Official Title
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The Effect of Endoscopic Procedures After Radical Prostatectomy on Urinary Incontinence

Conditions
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Prostate Cancer, Incontinence

Intervention / Treatment
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* Procedure: endoscopic surgical intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients who have undergone radical prostatectomy Patients that had undergone an endoscopic procedure 1 year after RP Exclusion Criteria: Patients with urinary tract infection before the endoscopic procedure, Urinary tract infection at 1st month follow-up Central neurological deficit History of adjuvant radiotherapy after RP Bladder neck stenosis and urethral stenosis Patients that had undergone endoscopic urethral intervention before this scheduled procedure Patients who had a double J stent inserted during the endoscopic procedure and required a second endoscopic intervention Patients that required the use of bipolar or monopolar cautery

Ages Eligible for Study
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Minimum Age: 52 Years
Maximum Age: 84 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: rigid cystoscopy<br>Group undergoing endoscopic urethral procedure with rigid cystoscopy after radical prostatectomy | Procedure: endoscopic surgical intervention<br>* The researchers investigated whether endoscopic surgical procedures performed due to various indications (hematuria, urinary tract stone, suspected bladder mass) in the patient group who had undergone radical prostatectomy, caused a change in urinary incontinence level. The researchers divided the endoscopic instruments used into 3 groups and evaluated whether there was a difference in urinary incontinence level between rigid cystoscope, flexible cystoscope and ureterorenoscope groups.<br>|
| Active Comparator: flexible cystoscopy<br>Group undergoing endoscopic urethral procedure with flexible cystoscopy after radical prostatectomy | Procedure: endoscopic surgical intervention<br>* The researchers investigated whether endoscopic surgical procedures performed due to various indications (hematuria, urinary tract stone, suspected bladder mass) in the patient group who had undergone radical prostatectomy, caused a change in urinary incontinence level. The researchers divided the endoscopic instruments used into 3 groups and evaluated whether there was a difference in urinary incontinence level between rigid cystoscope, flexible cystoscope and ureterorenoscope groups.<br>|
| Active Comparator: semi-rigid ureterorenoscopy<br>Group undergoing endoscopic urethral procedure with semi-rigid ureterorenoscopy after radical prostatectomy | Procedure: endoscopic surgical intervention<br>* The researchers investigated whether endoscopic surgical procedures performed due to various indications (hematuria, urinary tract stone, suspected bladder mass) in the patient group who had undergone radical prostatectomy, caused a change in urinary incontinence level. The researchers divided the endoscopic instruments used into 3 groups and evaluated whether there was a difference in urinary incontinence level between rigid cystoscope, flexible cystoscope and ureterorenoscope groups.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-SF) | The ICIQ-UI Short Form is a questionnaire for evaluating the frequency, severity and impact on quality of life (QoL) of urinary incontinence in men and women in research and clinical practice across the world. Minimum score: 0, maximum score: 21. The higher the score, the higher the level of urinary incontinence is interpreted. | 1 month | 
| Daily pad use | It refers to the number of pads used in 1 day due to urinary incontinence. | 1 month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Prostate Cancer, Urinary Incontinence, Endoscopic Surgical Procedures