Analysis of BPA Concentration in Serum in Women of Reproductive Age With Autoimmune Thyroid Disease

Study Overview
=================
Brief Summary
-----------------
The aim of the study is to assess the relationship between the concentration of bisphenol A in serum and selected parameters of thyroid function in women of reproductive age with thyroid dysfunction - Hashimoto's disease and Graves' disease.

Official Title
-----------------
Analysis of Bisphenol A Concentration in Serum in Women of Reproductive Age With Autoimmune Thyroid Disease

Conditions
-----------------
Hashimoto Disease, Hypothyroidism, Hyperthyroidism, Graves Disease

Intervention / Treatment
-----------------
* Diagnostic Test: Serum BPA


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Graves' disease or Hashimoto's disease (positive thyroid autoantibody) Control group: thyroid autoantibody negative, normal thyroid function Women aged 18 to 45 in both the control group and experimental group Exclusion Criteria: Pregnancy and lactating women Previous or planned treatment with 131I or thyroidectomy The use of drugs affecting the thyroid function (lithium, amiodarone, interferon a, sodium nitroprusside, sunitinib, sorafenib, iodine contrast, antibiotics / antifungals / antivirals (for at least 4 weeks prior to recruitment to the study), which do not result from the treatment of thyroid disease (levothyroxine, thyreostatic drugs, glucocorticoids) Active malignancy Other autoimmune diseases Other endocrine diseases Patients with severe liver, kidney or heart failure

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Hashimoto's Group<br>Thyroid antibody positive and hypothyroidism | Diagnostic Test: Serum BPA<br>* Serum BPA levels will be compared between women with autoimmune thyroid disease and normal women.<br>|
| Graves' Group<br>Thyroid antibody positive and hyperthyroidism | Diagnostic Test: Serum BPA<br>* Serum BPA levels will be compared between women with autoimmune thyroid disease and normal women.<br>|
| Control Group<br>Thyroid antibody negative and euthyroidism | Diagnostic Test: Serum BPA<br>* Serum BPA levels will be compared between women with autoimmune thyroid disease and normal women.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of serum BPA levels between the group with AITD and control group |  | Dec 2020 - April 2021 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The association between serum BPA levels and serum thyroid hormone levels in the AITD group | To determine the association between serum BPA concentrations and serum thyroid hormone levels in adult women | Dec 2020 - April 2021 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bisphenol A, Hashimoto's Disease, BPA, Graves' Disease