Syndrome and Aspiration Pneumonia in Intensive Care

Study Overview
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Brief Summary
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Inhalation is a common condition in patients with impaired their awareness requiring protection of the upper airway by endotracheal intubation. This inhalation may lead to chemical pneumonitis and/or bacterial pneumonia. Only the latter requires the administration of antibiotics. Patients developing such a bacterial pneumonia, has a mortality, duration of mechanical ventilation and length of ICU stay increased. However, the proportion of patients with such bacterial pneumonia, bacterial ecology and morbidity that are little known. The aim of this study is to determine the frequency of bacterial pneumonia in patients admitted to the ICU for coma and treated with mechanical ventilation

Official Title
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Syndrome and Aspiration Pneumonia in Intensive Care

Conditions
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ICU Patients, Under Mechanical Ventilation, In State of Coma (Define by Glasgow ≤ 8), No Antibiotic Treatment

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Altered consciousness defined by a Glasgow Coma Scale score less than or equal to 8 before protection of the upper airway by endotracheal intubation Patient under mechanical ventilation Exclusion Criteria: Patient with pre-existing impairment of laryngeal function in Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, laryngeal cancer, radiotherapy laryngeal Patient under guardianship Inpatient without consent Pregnant woman Patient previously treated with antibiotics for more than 24 hours at the time of ICU admission Patient with infection at ICU admission which justified probabilist antibiotic treatment Lack of social security Refusal of the patient or their next of kind

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Coma patients in ICU under mechanical ventilation<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Determine the frequency of bacterial pneumonia in patients admitted to the ICU for coma and treated with mechanical ventilation | Participants will be followed for the duration of ICU stay, an expected average of 4 days | ICU Discharge | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quantify the use of antibiotics during the ICU stay for patients admitted to the ICU for coma and treated with mechanical ventilation | Participants will be followed for the duration of ICU stay, an expected average of 4 days | ICU Discharge | 
| Description of the bacterial flora identified in respiratory specimens. | Participants will be followed for the duration of ICU stay, an expected average of 4 days | ICU Discharge | 
| Identification of predictive factors for development of bacterial pneumonia | Participants will be followed for the duration of ICU stay, an expected average of 4 days | ICU Discharge | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Aspiration pneumonia, Coma, Mechanical ventilation