Swiss Kidney Stone Cohort (SKSC)

Study Overview
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Brief Summary
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The SKSC is a continuous database with the objective of a standardized diagnosis and monitoring of patients with kidney stones as well as the establishment of a Biobank.

Detailed Description
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The objective of this study is multi-site, standardized observation and characterization of kidney stone patients. Furthermore, an adequate structure should be established for the execution of studies with kidney stone patients, in order to then, if necessary, develop recommendations for useful monitoring or prophylactic measures, as well as new treatment options for kidney stone patients. A control group of 250 stone-free volunteers matching patients cohort participants for sex and age started recruitment in October 2017 and will serve the purpose of comparison in future studies.

Official Title
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Swiss Kidney Stone Cohort (SKSC)

Conditions
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Kidney Stone

Participation Criteria
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Eligibility Criteria
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For SKSC Patients Group: Inclusion Criteria: Only patients that meet all of the following inclusion criteria can be included in this study: Signed Declaration of informed consent Male or female Recurrent kidney stone episodes (more than 1) or an individual kidney stone episode with one or several of the following risk factors: The first manifestation at the a minimum age of 25 Positive family history Non-calcium oxalate stones Gastrointestinal disorders (e.g. gastric bypass surgery, inflammatory bowel disease, malabsorption etc.) Osteoporosis Nephrocalcinosis Single kidneyness Currently pregnant Gout Metabolic syndrome ( Diabetes Mellitus type I and II ) Residual calculi (at least 3 months after the therapy) Bilateral or multiple stones Chronic urinary tract infection Chronic renal failure (eGFR lower than 60 ml/min.) Kidney transplant Exclusion Criteria: Patients with at least one of the following exclusion criteria may not take part in this study. Not signed Informed Consent form Age below 18 years old For SKSC Control Group Inclusion criteria: Signed Declaration of informed consent Male or female Kidney-stone free (screening verification by low-dose CT-scan) Exclusion criteria: Not signed Informed Consent form Age below 18 years old Pregnancy History of kidney stones Low-dose CT-scan positive for kidney stones during screening phase

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| SKSC Patients group<br>A group a 1000 subjects affected by kidney stone as described in the eligibility criteria will be recruited in the period 2014-2024 and the same exams will be repeated for each participants for a period of 3 years. No intervention will be undertaken. | |
| SKSC Control group<br>A group of 250 stone-free participants will be recruited and analysed with the same protocol as the patients but in a single visit. This group will be used for comparison with the patients group in future studies. No intervention will be undertaken. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Epidemiological characterization | Epidemiological characterization of kidney stone patients | 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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kidney stone