Determinants of Muscle Strength in Chronic Kidney Disease

Study Overview
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Brief Summary
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Aim of this study is to determine in chronic kidney disease patients: the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment the relationship between voluntary muscle strength and muscle mass the relationship between voluntary muscle strength and lean body mass the correlation between voluntary muscle strength and physical activity

Detailed Description
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Aim of this study is to determine in chronic kidney disease patients: the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment (estimated by handheld dynamometer) the relationship between voluntary muscle strength and muscle mass (estimated by creatinine index) the relationship between voluntary muscle strength and lean body mass (estimated by bioelectrical impedance analysis) the correlation between voluntary muscle strength and physical activity (the physical activity being estimated by the Voorrips score questionnaire)

Official Title
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Determinants of Muscle Strength in Chronic Kidney Disease

Conditions
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Chronic Kidney Disease

Intervention / Treatment
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* Device: Handheld dynamometer
* Biological: Creatinine index
* Device: Electrical bioimpedance analysis
* Other: Voorrips score questionnaire
* Biological: Inflammatory and nutritional status


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: chronic kidney disease patient with extrarenal replacement therapy by hemodialysis for at least 3 months stable clinical condition (absence of infection, stroke or acute decompensation) Exclusion Criteria: chronic kidney disease without extrarenal replacement therapy history of renal transplantation

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 90 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Muscle strength<br>single evaluation (the day of inclusion) of muscle strength (by handheld dynamometer), muscle mass (by creatinine index estimation), lean body mass (by electrical bioimpedance analysis), physical activity (by Voorrips score questionnaire), inflammatory and nutritional status. | Device: Handheld dynamometer<br>* Evaluation of muscle strength<br>Biological: Creatinine index<br>* Evaluation of muscle mass using plasma creatinine level<br>Device: Electrical bioimpedance analysis<br>* Evaluation of lean body mass<br>Other: Voorrips score questionnaire<br>* Evaluation of physical activity<br>Biological: Inflammatory and nutritional status<br>* Evaluation of C reactive protein and albumin<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Voluntary muscle strength evaluated by handheld dynamometer | data will be measured in Newton.meter | 1 day | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle mass estimated by creatinine index evaluation | data will be obtained from plasma creatinine level and will be expressed in milligram/kilogram/day) | 1 day | 
| Lean body mass evaluated by electrical bioimpedance analysis | data will be expressed in kilogram | 1 day | 
| Physical activity estimated using the Voorrips score questionnaire | the score represents the daily physical activity according to a validated scale | 1 day | 
| C reactive protein level | the parameter will be measured in milligram/liter | 1 day | 
| Albumin level | the parameter will be measured in gram/liter | 1 day | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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muscle mass, chronic kidney disease, malnutrition inflammation atherogenesis syndrome, muscle strength, lean body mass, physical activity