Bone Healing in Immediate Dental Implants

Study Overview
=================
Brief Summary
-----------------
To study the effect of platelet-rich plasma concentrate on marginal bone loss and bone mineral density in immediate implant placement through CBCT.

Detailed Description
-----------------
12 subjects were equally categorized into two groups. Group, I was the control group; whereas, the subjects in Group II received Platelet Rich Plasma (PRP) therapy. All subjects were given a standard treatment with single implant system. Inserted implants were analyzed through Cone Beam Computerized Tomography (CBCT). Records were registered at the baseline, at 12th week before functional loading and 26th week after functional loading.

Official Title
-----------------
Effect of PRP on Bone Healing in Immediate Implants Analyzed by CBCT

Conditions
-----------------
Alveolar Bone Loss, Platelet Rich Plasma

Intervention / Treatment
-----------------
* Biological: PRP injection
* Device: Automated blood cell separator to extract PRP


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients maintaining good oral hygiene, having adequate bone quantity at the implant site, uneventful extraction Exclusion Criteria: Active infection around implant site, immunocompromised state, with current major systemic disease (uncontrolled diabetes, rheumatoid arthritis, etc.) or oral pathologies, history of bleeding disorders or on anticoagulant therapy, or patients on bisphosphonates were excluded from the study

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control Group<br>Dental implant was placed in these patients following full protocol of immediate implant placement. | |
| Experimental: PRP Group<br>In this group Platelet Rich Plasma (PRP) was injected in soft tissue over surgical site. | Biological: PRP injection<br>* PRP was prepared using patient's blood and mixed with saline or mixture of calcium chloride and thrombin to form a liquid solution; in order to inject at the surgical site after placement of implant.<br>* Other names: Platelet Rich Plasma injection;Device: Automated blood cell separator to extract PRP<br>* Blood was withdrawn from antecubital vein and mixed with anticoagulant. Blood sample was then centrifuged to obtain platelet rich plasma which was injected at surgical site after implant placement.<br>* Other names: Automated blood cell separator/ centrifuge;|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of bone loss at baseline (12 weeks) and later at 26weeks | Measurement at mesial in mm | Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Measurement of bone loss at baseline (12 weeks) and later at 26weeks | Measurement at distal in mm | Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Dental implant, Cone Beam Computerized Tomography (CBCT).