Vestibular Evaluation After Vestibular Schwannoma Treatment

Study Overview
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Brief Summary
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Vestibular schwannoma is a benign tumor located on the vestibular nerve. Patient could present dizziness symptoms cause to the tumor, and at least after the treatment by gamaknife radiosurgery or microsurgery resection. Only few studies keep the interest about dizziness symptoms and treatment modality in vestibular schwannoma. In the study dizziness symptoms were compared before and after the treatment of vestibular schwannoma by radiosurgery gammaknife or microsurgery resection. 2 scales were used : dizziness handicap inventory (DHI) and dizziness functionnal scale (AAO).

Official Title
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Vestibular Evaluation Before and After Treatment of Vestibular Schwannoma. Comparison of Gamma Knife Radiosurgery and Microsurgical Resection

Conditions
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Dizziness

Intervention / Treatment
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* Radiation: Radiosurgery gammaknife
* Procedure: Microsurgery resection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patient treated of an one side vestibular schwannoma between 01/01/2012 and 31/12/2017, follow at the Grenoble University Hospital treatment : gamaknife radiosurgery or microsurgery resection no opposition of the patient Exclusion Criteria: association of gamaknife radiosurgery and microsurgery resection bilateral vestibular schwannoma

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| radiosurgery gammaknife group<br>Patient treated by radiosurgery gammaknife for a one side vestibular schwannoma | Radiation: Radiosurgery gammaknife<br>* This procedure use intense gamma ray, which are concentrated to the precise volume of the tumor that used to stop the progression of the tumor<br>|
| microsurgery resection group<br>Patient treated by microsurgery resection for a one side vestibular schwannoma | Procedure: Microsurgery resection<br>* Classical surgical approach with oto-neurosurgery procedures<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Vestibular evaluation DHI | The investigator use a standarised scale : - Dizziness Handicap Inventory (DHI). This scale combines 25 questions with three answers for each proposition about dizzyness in daily life situation : everytime (quote 4), sometimes (quote 2), never (quote 0). The scores are summing to obtain a value on 100. The scale is completed before and after the treatement. The investigator send the scale to the patient by mail way. | From 4 years to 6 months | 
| Vestibular evaluation AAO | The investigator use a standarised scale : - Dizziness Functionnal Scale (AAO), this is a scale quote from 1 (no symptoms of dizzyness) to 6 (major disability). The patient have to choise only one item that correspond to the condition. The scale is completed before and after the treatement. The investigator send the scale to the patient by mail way. | From 4 years to 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Facial fonction | House and Brackmann scale : This scale is a standarised assessment of facial fonction from grade I : normal ; to grade VI : total paralysis. Each scale is completed after the treatement. | From 4 years to 6 months | 
| Hearing function | This information is based on a question to the patient about the usefulness of hearing prothesis. So there are 2 groups : useful hearing (normal hearing or used hearing prothesis) or useless hearing (unsused hearing prothesis) The information is completed before and after the treatement. | From 4 years to 6 months | 
| Tumor control | Tumor control is based on MRI size description (in mm): So there are 2 groups : controled or evolution of the tumor. for microsurgery resection group the investigator keeps interest about the remaining size for radiosurgery gammaknife group the investigator keeps interest about the stability or the reduction of the tumor The result is completed after the treatement. | From 4 years to 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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vestibular schwannoma, gammaknife radiosurgery, vestibular evaluation