Preterm Lung Function and Exercise Response Measured by OEP

Study Overview
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Brief Summary
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This study will explore lung function and respiratory health in school-aged children who were born prematurely at <32 weeks gestation. It will involve full lung function assessment, a questionnaire and discussion about respiratory health, and an exercise test using optoelectronic plethysmography (OEP) to measure breathing patterns.

Detailed Description
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Preterm are born during a critical stage of lung development, and can have abnormalities in lung function that persist with age. Previous studies have shown that children with BPD have reduced lung function and limited exercise capacity. These studies have used conventional lung function testing which requires a tight fitting mask. This is uncomfortable, may alter normal breathing patterns and cannot measure changes in total lung volume. Optoelectronic plethysmography (OEP) indirectly measures lung volumes and breathing patterns using cameras to track the position of marker stickers on the chest, back and abdomen. It is comfortable, does not require a mask and allows us to track changes in total lung volume. This study will use standard lung function testing and OEP to measure lung function and breathing patterns at rest and during exercise in school-aged children born prematurely, compared to healthy children born at full term. All participants will complete standard lung function tests, a questionnaire and structured interview to qualitatively assess respiratory health, and an exercise test using OEP to assess how breathing changes with exercise.

Official Title
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Lung Function and Exercise Response Measured by Optoelectronic Plethysmography in School-aged Children Born Preterm

Conditions
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Premature Birth

Intervention / Treatment
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* Diagnostic Test: Lung function + exercise tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 8-16 years Born at <32 weeks gestation (preterm) or >37 weeks gestation (controls) Parental consent obtained Exclusion Criteria: Unable to comply with test procedure Respiratory illness within last 2 weeks Cardiac disease (excludes ligated PDA) Neuromuscular disease

Ages Eligible for Study
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Minimum Age: 8 Years
Maximum Age: 16 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Preterm<br>Children age 8-16 years born at <32 weeks gestation. | Diagnostic Test: Lung function + exercise tests<br>* Lung function + exercise tests<br>|
| Control<br>Children age 8-16 years born at >37 weeks gestation | Diagnostic Test: Lung function + exercise tests<br>* Lung function + exercise tests<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in end-expiratory lung volume with exercise | Change in end-expiratory lung volume measured in litres with exercise measured using optoelectronic plethysmography | Pre + post exercise (10minutes) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in tidal volume with exercise | Change in tidal volume with exercise measured in litres using optoelectronic plethysmography | During exercise (10 minutes) | 
| Change in minute ventilation with exercise | Change in minute ventilation (measured in litres/minute) with exercise measured using optoelectronic plethysmography. | During exercise (10 minutes) | 
| Baseline forced expiratory volume in 1 second (FEV1) | Baseline forced expiratory volume (in litres) in 1 second measured by spirometry (FEV1) | Baseline | 
| Forced vital capacity (FVC) | Baseline forced vital capacity measured in litres (FVC) | Baseline | 
| Forced mid-expiratory flow (FEF25-75%) | Mean forced expiratory flow between 25% and 75% of FVC measured in litres/second (FEF25-75%) | Baseline | 
| Transfer factor for carbon monoxide (TLCO) | Transfer factor for carbon monoxide (measured in millimoles per minute per kilopascal) using single breath test | Baseline | 
| Body plethysmography | Baseline lung volume (in litres) measured using body plethysmography | Baseline | 
| FeNO | Baseline FeNO (fraction of exhaled nitric oxide) | Baseline | 
| Exercise induced bronchoconstriction | % change in FEV1 | 10 minutes post exercise | 
| Baseline activity levels | Baseline activity levels measured using Actigraph monitor | 1 week period | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Lung function, Exercise