The Effect Of Anaerobic Exercise On Bone Morphogenetic Protein 9

Study Overview
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Brief Summary
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Bone morphogenetic protein (BMP) 9 from the BMP family has an important role in the remodeling of bone and cartilage. Due to these features, BMP9 can play an important role in especially anaerobic exercise training adaptations. However, the role of anaerobic exercise in these effects is still unclear. The aim of this study is to investigate the role of BMP9 on the effects of acute and chronic anaerobic exercise on bone metabolism markers. Postprandial venous blood samples were taken pre- and post- acute YOYO intermittent recovery test (level 1) in 40 trained male athletes aged 18-35 who did anaerobic sports (such as basketball, volleyball and handball) and 41 sedentary volunteers aged 18-35. Serum BMP9, as markers of bone formation and resorption; alkaline phosphatase (ALP), C-terminal telopeptide of type 1 collagen (CTX1), cartilage oligomeric matrix protein (COMP) and calcium levels were determined. The data to be obtained as a result of our study can give information about the relationship between the skeletal and bone health of the athletes and anaerobic exercise.

Official Title
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The Effect Of Anaerobic Exercise On Bone Morphogenetic Protein 9

Conditions
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Healthy, Exercise

Intervention / Treatment
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* Other: Physiological test
* Other: Physical test
* Other: Biochemical tests


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: being male having a body mass index of less than 30 being Exclusion Criteria: to have some disease or disability to regularly use cigarettes and alcohol to use any medication or antioxidant substance

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 35 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Athletic group<br>Healthy male athletes who have been doing regular anaerobic sports (such as basketball, volleyball and handball) for at least 3 months | Other: Physiological test<br>* This test was conducted to determine the endurance levels of the participants.<br>* Other names: YOYO intermittent recovery test (level 1);Other: Physical test<br>* Height, weight, and BMI were determined<br>Other: Biochemical tests<br>* BMP9, CTX1, COMP, oxLDL protein levels, ALP, GGT, TAS, TOS, OSI, NO, calcium, T-C, LDL-C, Triglyceride, HDL-C, glucose, CRP, AST, ALT, erythrocyte, mean erythrocyte volume (MCV), hematocrit, leukocyte, thrombocyte levels were determined from blood samples.<br>|
| Control group<br>Healthy sedentary (not doing regular sports for at least 3 months) men with age and physical characteristics similar to the athlete group | Other: Physiological test<br>* This test was conducted to determine the endurance levels of the participants.<br>* Other names: YOYO intermittent recovery test (level 1);Other: Physical test<br>* Height, weight, and BMI were determined<br>Other: Biochemical tests<br>* BMP9, CTX1, COMP, oxLDL protein levels, ALP, GGT, TAS, TOS, OSI, NO, calcium, T-C, LDL-C, Triglyceride, HDL-C, glucose, CRP, AST, ALT, erythrocyte, mean erythrocyte volume (MCV), hematocrit, leukocyte, thrombocyte levels were determined from blood samples.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change from serum BMP9 levels at pre- and post- YOYO intermittent test | Postprandial venous blood samples were obtained before and after acute YOYO IR test (level 1). The YOYO test lasted 10-20 minutes depending on the ability level of the participants. A blood sample was taken 15 minutes before and 15 minutes after the YOYO test. From these blood samples, serum Bone morphogenetic protein 9 (BMP9) was determined. | between 40-50 minutes | 
| Change from serum CTX1 levels at pre- and post- YOYO intermittent test | Postprandial venous blood samples were obtained before and after acute YOYO IR test (level 1). The YOYO test lasted 10-20 minutes depending on the ability level of the participants. A blood sample was taken 15 minutes before and 15 minutes after the YOYO test. From these blood samples, serum C-terminal telopeptide of Type 1 collagen (CTX1) was determined. | between 40-50 minutes | 
| Change from serum COMP levels at pre- and post- YOYO intermittent test | Postprandial venous blood samples were obtained before and after acute YOYO IR test (level 1). The YOYO test lasted 10-20 minutes depending on the ability level of the participants. A blood sample was taken 15 minutes before and 15 minutes after the YOYO test. From these blood samples, serum cartilage oligomeric matrix protein (COMP) was determined. | between 40-50 minutes | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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BMP9, Bone morphogenetic protein, anaerobic exercise