MRI of Infrapatellar Fat Pad in Osteoarthritis

Study Overview
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Brief Summary
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In this study, the investigators use the clinical documentation and imaging data of MRI to do research. Clinical subjects were divided into two groups: osteoarthritis patients and healthy controls without osteoarthritis. Differences of MRI data were studied between two groups.

Detailed Description
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In this study, the investigators applied high precision MRI technique (with as less as a slice thickness of 0.35 mm and without inter-slice gap), and calculated not only the IPFP maximal sagittal area and IPFP volume, but also the quantitated signal, and compared the differences between healthy controls and osteoarthritis patients. This is an observational cross-sectional study without specific interventions to the subjects. MRI is a regular examination in our hospital. And all subjects are included for the reasons of osteoarthritis (need MRI) and healthy controls (pain but not osteoarthritis, also need MRI). The investigator does not assign specific interventions to the subjects of the study.

Official Title
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Magnetic Resonance Imaging of Infrapatellar Fat Pad in Osteoarthritis and Controls

Conditions
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Osteoarthritis

Intervention / Treatment
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* Radiation: Magnetic resonance imaging


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with clinical knee osteoarthritis; The healthy controls who require MRI test. Exclusion Criteria: Contraindications to magnetic resonance imaging; Rheumatoid arthritis patients; Gout; Hemophilic arthritis; Subjects who take non-steroidal anti-inflammatory drugs (NSAIDs); Subjects who take lipid-lowering agents; Subjects who have the history of knee trauma; Subjects who have the history of knee operation; Subjects who have the disease of musculoskeletal tumor near knee; Subjects who have joint loose bodies.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| osteoarthritis patients<br>3.0 Tesla Magnetic resonance imaging was analyzed. It's the documentation from the outpatients and inpatients with osteoarthritis. It's not the intervention the study applied, but the subjects' disease demands. | Radiation: Magnetic resonance imaging<br>* 3.0 T Magnetic resonance imaging of knee joints. It does not harm the subjects.<br>|
| healthy controls<br>3.0 Tesla Magnetic resonance imaging was analyzed. It's the documentation from the outpatients and inpatients without osteoarthritis. It's not the intervention the study applied, but the subjects' non-osteoarthritis knee symptom demands. | Radiation: Magnetic resonance imaging<br>* 3.0 T Magnetic resonance imaging of knee joints. It does not harm the subjects.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Infrapatellar Fat Pad Volume in MRI |  | collect the data within 24 hours after the subjects did the MRI |