Combination of Spinal-Epidural With General Anesthesia in Patients Undergoing Mega-Liposuction Surgery

Study Overview
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Brief Summary
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The combination of general anesthesia to spinal and epidural techniques (CSEGA) proved to have a synergistic effect, thus, the use of sub-anesthetic doses can provide satisfactory anesthetic and analgesic results. CSEGA has several known advantages including appropriate postoperative analgesia, shows some benefit in the intraoperative blood loss control causing a decreased need for blood transfusion, rapid regain of the gastrointestinal actions and decreases the incidence of postoperative respiratory complications. Unfortunately, the drawbacks of using neuro-axial anesthesia in combination to general anesthesia will be not thoroughly introduced in many researches, thus, remain unclear.

Official Title
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Combination of Spinal-Epidural With General Anesthesia in Patients Undergoing Mega-Liposuction Surgery

Conditions
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Combination of General Anesthesia to Spinal and Epidural Techniques

Intervention / Treatment
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* Device: spinal-epidural device


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Patients aged from 18 to50 years. ASA I-II. undergoing elective liposuction surgery BMI from 25 to 40 kg/m2 Exclusion criteria: Patient refusal ASA III-IV. Patients aged less than 18 or more than 50. Body mass index >40. Any contraindications to neuro-axial block such as coagulopathy or spine deformity Chronic opioid consumption, History of parenteral or oral analgesic intake within the last 48hours.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: CSEGA group<br>Will be received combined spinal-epidural-general anesthesia. | Device: spinal-epidural device<br>* received combined spinal-epidural-general anesthesia.<br>|
| No Intervention: GA group<br>will be received general anesthesia only. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| morphine consumption | postoperative morphine consumption | 24 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative patient satisfaction | 1 = very unsatisfactory; 2 = unsatisfactory; 3 = indifferent; 4 = satisfactory; and 5 = very satisfactory. | 24 hours | 
| Intraoperative surgeon satisfaction. | using 1-4 scales (1, bad; 2, moderate; 3, good; 4, excellent; | 6 hours | 
| Incidence of complications | such as hypotension, bradycardia, nausea and vomiting, postoperative shivering, | 24 hours | 
| Blood loss | intraoperative Blood loss | 6 hours |