Chronic Insomnia and CSF Markers of Dementia

Study Overview
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Brief Summary
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The longstanding view has been that insomnia, and other forms of sleep disturbance, emerge as a consequence of dementia and are the result of progressive neuronal damage. However, there is growing evidence that the direction of causation may go both ways, with sleep disturbance potentially increasing vulnerability to dementia. Longitudinal studies have found that sleep disturbance often precedes and increases risk for dementia by several years.The purpose of this study is to examine the relationship between chronic insomnia and dementia biomarkers and orexin levels found in cerebrospinal fluid (CSF). Fifteen adults age 30-50 with chronic insomnia and age- and gender-matched good sleepers will undergo overnight polysomnography and CSF sampling in the morning.

Official Title
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Chronic Insomnia and CSF Markers of Dementia

Conditions
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Insomnia Chronic

Intervention / Treatment
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* Other: lumbar puncture


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 30-50 Men and women To be included in the insomnia group, subjects must meet the following DSM5 Diagnostic Criteria for insomnia disorder: dissatisfaction with sleep quantity or quality (difficulty initiating or maintaining sleep, or waking up too early) despite adequate opportunity for sleep; sleep disturbance causes clinical significant distress or impairment in functioning; present at least 3 times per week for at least 3 months; sleep disturbance is not better explained by a medical or psychiatric condition or based on the effects of a substance Exclusion Criteria: Diagnosis or evidence of sleep disorders other than insomnia as determined by the screening questionnaires and clinical history Women who have been pregnant or lactating within the past six months Non-fluency in spoken or written English Current or past month shiftwork defined as working during the evening or night shift Current use of medications or OTC products that impact sleep Evidence of neurological abnormalities that could include the risks associated with lumbar puncture (e.g.papilledema, mass lesion, Chiari malformation).

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Individuals with insomnia<br>Men and women with chronic insomnia (>5 years duration) | Other: lumbar puncture<br>* Subjects will have a lumbar puncture to collect cerebrospinal fluid collection<br>|
| Good sleepers<br>Men and women with a longstanding pattern of good sleep | Other: lumbar puncture<br>* Subjects will have a lumbar puncture to collect cerebrospinal fluid collection<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CSF markers related to dementia | CSF levels of the proteins tau and beta amyloid | one morning | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| CSF levels of orexin | Orexin is a chemical in the brain related to sleep regulation | one morning |