Prenatal Screening of Intestinal Malrotation With a Higher Risk of Volvulus.

Study Overview
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Brief Summary
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Digestive malrotation is an anatomical anomaly of the positionning of the mesenteric vessels and the digestive tract that can lead in some form to a dangerous neonatal complication: intestinal volvulus. This requires emergency surgery with a risk of digestive resection. Visualizing during pregnancy the normal or abnormal anatomical positionning of the mesenteric vessels could make it possible to diagnose this malrotation and prevent the occurrence of this complication. The aim of the study is to study the neonatal outcome of fetus confirm to have an abnormal positionning of mesenteric vessels

Official Title
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Prenatal Screening of Intestinal Malrotation With a Higher Risk of Volvulus: Value of the Ultrasound Study of the Relative Position of the Superior Mesenteric Vessels and Fetal Abdominal MRI.

Conditions
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Postnatal Complication, Mesenteric Pregnancy

Intervention / Treatment
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* Other: Ultrasound exam
* Other: Fetal MRI
* Other: Postnatal abdominal ultrasound
* Other: Pediatric Follow up


Participation Criteria
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Eligibility Criteria
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Inclusion criteria: Pregnant women attending for 2nd trimester ultrasound Abnormal positionning of mesenteric vessels No other foetal malformation Singleton pregnancy Age >18 years Exclusion criteria: Chromosomal abnormality polymalformative syndrom Foetal malformation changing intestine disposition (gastroschisis, diaphragmatic hernia, heterotaxis…)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Fetuses with abnormal positionning of mesenteric vessels<br>All pregnant women with abnormal positionning of mesenteric vessels during second trimester scan | Other: Ultrasound exam<br>* Ultrasound exam<br>Other: Fetal MRI<br>* Fetal MRI<br>Other: Postnatal abdominal ultrasound<br>* Postnatal abdominal ultrasound<br>Other: Pediatric Follow up<br>* Pediatric Follow up<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percentage of intestinal malrotation among foetuses | Percentage of intestinal malrotation among foetuses with abnormal positionning of mesenteric vessels | day 1 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of correlation between prenatal | Rate of correlation between prenatal | day 1 | 
| Rate of postnatal ultrasound | Rate of postnatal ultrasound | day 1 | 
| type of intestinal malrotation | type of intestinal malrotation | day 1 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pregnant women, 2nd trimester ultrasound examination, Mesenteric vessels positionning, Pediatric follow up +/- treatment, Postnatal confirmation, Evolution and complication