Erector Spinae Plane Block in Liver Transplantation Donors

Study Overview
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Brief Summary
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Living donor liver transplantation has become a common treatment option for patients with end-stage liver disease. Donor hepatectomy is associated with significant postoperative pain due to inverted L-shaped incision. Therefore adequate analgesia is important for recovery. Erector Spinae Plane Block (ESPB) is a safe anesthesia technique used to provide postoperative analgesia. This study aimed to compare the novel ultrasound-guided ESPB technique with controls in terms of postoperative opioid consumption and postoperative pain control on donor patients.

Official Title
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Ultrasound-guided Bilateral Erector Spinalis Plane Block on Postoperative Pain Management in Liver Transplantation Donors

Conditions
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Pain, Postoperative

Intervention / Treatment
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* Procedure: Erector Spinae Plane Block
* Procedure: Intravenous fentanyl patient control device


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Donor patients scheduled for elective hepatectomy in liver transplantation surgery ASA I-II Patients who are aged between 18-65 Exclusion Criteria: Patients who do not accept the procedure Skin infection at the site of Erector Spina Plan Block area Coagulation disorder or using anticoagulant drugs Known local anesthetics and opioid allergy Severe pulmonary and/or cardiovascular problems Substance addiction or known psychiatric or mental problems Chronic painkiller usage Pregnancy or lactation

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: There are two model for this study. The first group is erector spinae plane block group. The second one is control group.
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Erector Spinae Plane Block<br>Erector Spinae Plane Block for Postoperative Analgesia | Procedure: Erector Spinae Plane Block<br>* Intravenous fentanyl patient control device 48-hour fentanyl consumption will be recorded.<br>|
| Active Comparator: Control group<br>No regional anesthesia technique will be applied to the control group. | Procedure: Intravenous fentanyl patient control device<br>* Intravenous fentanyl patient control device 48-hour fentanyl consumption will be recorded.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Opioid consumption | The amount of fentanyl required by the patient and given by the device will be recorded for the first 48 hours. | Change from baseline opioid consumption at postoperative 0, 2, 4, 6, 12, 24, 36 and 48 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Visual Analog Scale | Pain of patients will be evaluated and recorded according to the Visual Analog Scale. | Change from baseline pain scores at postoperative 0, 2, 4, 6, 12, 24, 36 and 48 hours |