Influence Of Nutritional Status Of Patients In The Intensive Care Output On Long Term Fate

Study Overview
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Brief Summary
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It is established that the surviving patients after a stay in the ICU are characterized by frequent malnutrition and morbidity and mortality. The main goal of this work is to study the relationship between nutritional statuses during ICU hospitalization, whatever its determinants, and quality of life, morbidity and mortality at one year. The hypothesis of the study is that the presence of under nutrition is responsible for a 10% increase in crude mortality at one year (which would be respectively 30% for malnourished patients and 20% for non-malnourished patients).

Detailed Description
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This is a multicenter cohort study of a 30-month follow-up on patients after a stay in ICU. Nutritional parameters and evaluation of the quality of life will be collected during hospitalization and output during a visit to the Clinical Research Associate at 6 months and one year. Survival will be also noted. These parameters will be studied in comparative patients malnourished and non-malnourished.

Official Title
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Influence Of Nutritional Status Of Patients In The Intensive Care Output On Long Term Fate

Conditions
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Nutritional Status at the Release of ICU.

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients of both sexes, age greater than or equal to 18 years Hospitalized more than 72 hours in the ICU Requiring at least one support organ failure: Ventilatory support (invasive or noninvasive) Administration of catecholamines Extrarenal purification whatever technique Affiliated to a social security system Having given free, informed written consent Exclusion Criteria: Patients with end-stage disease or for which a limitation of care was decided Pregnant women Patients with minor or under guardianship Incapacitated adults and psychiatric inpatients

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| all-cause mortality |  | at one year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Anxiety and depression |  | at inclusion, M6 and M12 | 
| Post-traumatic stress |  | at inclusion, M6 and M12 | 
| Quality of life |  | at M6 and M12 | 
| Degree of activity (Karnofsky questionnaire) |  | At M6 and M12 | 
| Weight |  | at inclusion, M6 and M12 | 
| Body mass index |  | at inclusion, M6 and M12 | 
| Albumin |  | at inclusion, M6 and M12 | 
| Orosomucoid |  | at inclusion, M6 and M12 | 
| Transthyretin (prealbumin) |  | at inclusion, M6 and M12 | 
| Body composition |  | at inclusion, M6 and M12 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ICU, Body composition, Nutrition, Survival, Morbidity