Interest of the T2 * Sequence in MRI for the Diagnosis of Migraine Aura in the Acute Phase.

Study Overview
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Brief Summary
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investigators hypothesize that T2 * vein abnormalities are frequent and are specific to the migraine aura.

Detailed Description
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The diagnosis of migraine aura is now based solely on clinical criteria and the assertion of the diagnosis on these clinical criteria alone proves difficult in the acute phase. Added to this difficulty, the symptomatology of a migraine aura can sometimes be similar to that of a stroke, so a diagnosis can be poorly established, resulting in poor patient care. The possibility of making the positive diagnosis of migraine aura on a routine MRI sequence, T2 *, would be an important advance for the management of these patients

Official Title
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Interest of the T2 * Sequence in MRI for the Diagnosis of Migraine Aura in the Acute Phase.

Conditions
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Migraine Aura

Intervention / Treatment
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* Combination Product: MRI
* Diagnostic Test: MRI control
* Other: telephone consultation


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients aged 18 to 55 years Admitted to the Neuro-Vascular Intensive Care Unit for Acute Focused Neurological Symptoms and MRI less than 4 hours 30 minutes after onset of symptoms if symptoms persist during admission less than two hours after the disappearance of symptoms if the patient arrives asymptomatic Affiliated to a social protection scheme. Having given their informed consent Exclusion Criteria: Patients with neurological signs pointing to vertebrobasilar localization (vertigo, diplopia) or with a disorder of consciousness Presence of recent explanatory abnormalities on the MRI to make a diagnosis compatible with the initial neurological symptomatology (visible stroke in diffusion, cerebral hemorrhage, tumor, arteriovenous malformations). Potential strong cause of stroke known or discovered at the arrival of the patient, in particular stenosis of a cervical or intracranial artery upstream of the cerebral zone may correspond to the symptoms and emboligenic heart disease type atrial fibrillation. Pregnant women - Patients with a contraindication for MRI. Patients benefiting from a system of legal protection (tutelage,

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: with migraine aura.<br>patient with migraine aura detected by MRI, then MRI control 3 month after | Combination Product: MRI<br>* Routine MRI with all the sequences performed for the management of acute neurological deficit in the Toulouse Neuro Vascular Unit (diffusion, FLAIR, T2 *, vascular sequences (AngioRM and TOF) and perfusion).<br>Diagnostic Test: MRI control<br>* MRI with all the sequences performed for the management of acute neurological deficit in the Toulouse Neuro Vascular Unit (diffusion, FLAIR, T2 *, vascular sequences (AngioRM and TOF) and perfusion)<br>|
| Other: without migraine aura<br>patient without migraine aura detected by MRI, then telephone consultation 3 month after | Other: telephone consultation<br>* telephone consultation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| frequency of the presence of visible brain vein abnormalities | visible brain vein abnormalities on T2 * sequences MRI , | Day 0 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| perfusion parameters | in MRI , Overall visual assessment: presence or absence of hypoperfusion (presence or not in each anterior, middle and posterior territory) each lobe: Frontal, Temporal, Parietal, Occipital) | Day 0 | 
| asymmetry of visualization of the 3 intracranial arteries in MRI | in MRI TOF | Day 0 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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migraine aura