Beverage Consumption and Fine Motor Control

Study Overview
=================
Brief Summary
-----------------
The aim of this study will be to compare the effects of daily consumption of aspartame, rebaudioside a, saccharin, sucralose, and sucrose on body weight and composition in a standardized protocol. The investigators hypothesize that individual low calorie sweeteners (consumed in a beverage) differ from each other in promoting weight loss and decreased fat mass (without energy restriction or dietary guidance) based on their chemical structure.

Official Title
-----------------
The Effect of Low Calorie Sweetener Consumption on Body Weight, Body Composition, Appetite, and Energy Intake

Conditions
-----------------
Body Weight

Intervention / Treatment
-----------------
* Dietary Supplement: Beverage


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: BMI between 25-40 kg/M2 Non or rare users of LCS Willing to consume large volumes of beverages daily Exclusion Criteria: Weight change > 3kg in the last year Plan to initiate a new diet plan in the next 6 months Exhibit eating restraint Pregnant/lactating

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Sucrose Sweetened Beverage<br>100-140 g sucrose/day | Dietary Supplement: Beverage<br>* Participants will receive 1.25 - 1.75 L of sweetened beverage a day for 12 weeks<br>|
| Experimental: Aspartame Sweetened Beverage<br>0.541-0.757 g aspartame Sweetened Beverage/day | Dietary Supplement: Beverage<br>* Participants will receive 1.25 - 1.75 L of sweetened beverage a day for 12 weeks<br>|
| Experimental: Saccharin Sweetened Beverage<br>0.300-0.455 g saccharin Sweetened Beverage/day | Dietary Supplement: Beverage<br>* Participants will receive 1.25 - 1.75 L of sweetened beverage a day for 12 weeks<br>|
| Experimental: Sucralose Sweetened Beverage<br>0.167-0.233 g sucralose Sweetened Beverage/day | Dietary Supplement: Beverage<br>* Participants will receive 1.25 - 1.75 L of sweetened beverage a day for 12 weeks<br>|
| Experimental: Rebaudioside A Sweeteened Beverage<br>0.250-0.350 g rebaudioside A Sweetened Beverage/day | Dietary Supplement: Beverage<br>* Participants will receive 1.25 - 1.75 L of sweetened beverage a day for 12 weeks<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body Weight |  | 12 weeks | 
| Body Composition | Duel emission X-ray absorbtiometry | 12 weeks | 
| Energy Intake | 24 hr Dietary Recall | 12 weeks | 
| Appetite | 24 hr visual analog scale appetite | 12 weeks | 
| Energy Expenditure | accelerometer | 12 weeks | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
energy intake, energy expenditure, appetite