High-flow Nasal Oxygen in Palliative Care: Pilot Study

Study Overview
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Brief Summary
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In palliative care, the relief of the dyspnea is necessary. Medications for the reduction of dyspnea have side effects. High-flow nasal cannula oxygen therapy (HFNC) is a new way to deliver oxygen. Investigators hypothesize that HNFC is an acceptable technic for the patient with dyspnea in palliative care. A pilot study with 30 patients will be conducted. Acceptability of HNFC will be studied by the time of use by patients of the HNFC during one week. The effectiveness of HNFC in relieving dyspnea will be studied using Borg scale.

Detailed Description
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Pilot study for acceptability of high flow nasal cannula oxygen therapy in palliative care Population: 30 patients in palliative care (for lung cancer, terminal respiratory failure) who suffer from dyspnea and have oxygen therapy. Patients with curative care are excluded and patients who require non invasive ventilation. An oral consent is asked. Primary objective: acceptability of HNFC in patients with dyspnea in palliative care during one week Secondary objectives: Tolerance of HNFC at short term (1h and 24h) and long term (7 days) after initiation of HNFC Efficiency of HNFC at short term Primary outcome: duration of use of the HNFC during 7 days Secondary outcome: Tolerance: noise of the system of HNFC, side effects of high flow (nasal dryness..) Efficiency: evaluation of dyspnea by Borg scale and measure of respiratory rate and saturation of oxygen one hour after initiation of HNFC

Official Title
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Acceptability of High-flow Nasal Oxygen to Relieve Dyspnea in Palliative Care: Pilot Study

Conditions
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Dyspnea

Intervention / Treatment
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* Device: high-flow nasal cannula oxygen therapy (HNFC)


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient followed for respiratory failure with palliative care and : More than 18 years old Dyspnea related to a respiratory disease Hypoxemia requiring the introduction of more than 4 liters of oxygen for a sp02 > 90% Patient affiliated to a social security system Exclusion Criteria: Patient less than 18 years old Patient with guardianship, trusteeship No consent for participation at the study Project of curative care

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: High-flow nasal oxygen<br> | Device: high-flow nasal cannula oxygen therapy (HNFC)<br>* Set up of high-flow nasal oxygen for patient with dyspnea for a respiratory disease without possibility of curative care. Patients who require a treatment by oxygen are included. After 7 days of treatment, acceptability is evaluated by the duration of use of HNFC.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acceptability of HNFC in patients with dyspnea in palliative care during one week | Duration of use of HNFC: nurses will set up the device to the patient who can withdraw it at any time. It will then be noted the stop time and recovery of the device for a week, which will know the time of use and acceptability. If the patient wishes to permanently stop the use of the device, the stop time will be raised. | 7 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Efficiency of high-flow nasal oxygen in palliative care with dyspnea | Evaluation of dyspnea with the Borg scale. The Borg scale is a scale containing 10 proposals ranging in increasing order of severity (from no gene at all to extremely embarrassed) that will allow the patient to grading his respiratory gene. | At short term: one hour after the initiation and at long term: 24h and seven days after the start | 
| Efficiency of high-flow nasal oxygen in palliative care with Sp02 | Evaluation of Sp02 using transcutaneous oximeter | At short term: one hour after the initiation and at long term: 24h and seven days after the start | 
| Efficiency of high-flow nasal oxygen in palliative care with respiratory rate | Evaluation of respiratory rate | At short term: one hour after the initiation and at long term: 24h and seven days after the start | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dyspnea, palliative care, high-flow nasal oxygen, pilot study