Assessment of Knee Arthrosis After Bariatric Surgery

Study Overview
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Brief Summary
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Impact of loss of weight on knee arthrosis has not been thoroughly studied. The primary goal of this study is to compare the MRI parameters (aspect of cartilage and oedema of spongious sub-chondral bone) before and one year after bariatric surgery. Knee MRI is not currently part of the investigations preceding bariatric surgery.

Detailed Description
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Assessment of knee arthrosis in severely obese patients after bariatric surgery. Impact of loss of weight on knee arthrosis has not been thoroughly studied. The primary goal of this study is to compare the MRI parameters (aspect of cartilage and oedema of spongious sub-chondral bone) before and one year after bariatric surgery.

Official Title
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Assessment of Knee Arthrosis in Severely Obese Patients After Bariatric Surgery.

Conditions
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Bariatric Surgery Candidate

Intervention / Treatment
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* Other: knee MRI


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: bariatric surgery IMC >= 35 Exclusion Criteria: those of bariatric surgery contra-indication to MRI pregnancy

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 59 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| knee MRI<br>knee MRI for all patients undergoing bariatric surgery as usual care | Other: knee MRI<br>* knee MRI before surgery (inclusion) and one year after<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| variation of knee joint space thickness | Joint space variation in percentages (mean joint space variation calculated for each patient group). Mean joint space comparison between 2 groups of obese patients: patients with Bypass surgery versus patients without surgery. | 24 hours, one year | 
| proportion of patients with pain | proportion of patients with Pain Scores on the Visual Analog Scale ≥ 30/100 (for at least one knee). Comparison at one year after bariatric surgery versus inclusion. | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| prevalence of atherosis | Pain Scores on the Visual Analog Scale >= 3 and/or radiological signs of atherosis | 24 hours | 
| mean pain and disability | mean Pain Scores on the Visual Analog Scale and mean value of KOOS index for knee function. | 24 hours | 
| evolution of KOOS score after surgery | Among the 80 patients undergoing surgery, comparison of KOOS function score before surgery versus 6 months, 1 year and two years after surgery. | 6 months, 1 year and two years | 
| evolution of pain scores after surgery | Among the 80 patients undergoing surgery, comparison of mean Pain Scores on the Visual Analog Scale before surgery versus 6 months, 1 year and two years after surgery. | 6 months, 1 year, 2 years | 
| evolution of the proportion of patients in pain | Among the 80 patients undergoing surgery, comparison of the proportion of patients with Pain Scores on the Visual Analog Scale ≥ 30/100 before surgery versus 6 months, 1 year and two years after surgery. | 6 months, 1 year and two years | 
| evolution of knee MRI parameters after surgery | Among the 80 patients undergoing surgery, comparison of the MRI parameters (T2, cartilage volume, œdema of sub-chondral spongious bone) before surgery versus 6 months, 1 year and two years after surgery. | 6 months, 1 year and two years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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knee arthrosis, obesity, MRI, bariatric surgery