Comparison Between Pregabalin and Magnesium Sulfate in Hypotensive Anaesthesia

Study Overview
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Brief Summary
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Comparison between pregabalin and magnesium sulfate in hypotensive anaethesia

Detailed Description
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compare the effect of a single-dose 150 mg oral pregabalin and 2 grams intravenous magnesium sulfate given 30 minutes before induction of anesthesia on the total nitroglycerine used in patients undergoing functional endoscopic sinus surgery

Official Title
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Comparison Between Single Dose Pregabalin and Magnesium Sulfate in Controlled Hypotension During Functional Endoscopic Sinus Surgery

Conditions
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Functional Endoscopic Sinus Surgery

Intervention / Treatment
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* Drug: Pregabalin 150mg
* Drug: Magnesium Sulfate
* Drug: Nitroglycerin
* Other: surgeon satisfaction


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: ASA: class 1 or 2 Sex: male and female Age: from 18 to 70 years Patients scheduled for functional endoscopic sinus surgery Exclusion Criteria: Patient on diuretics, corticosteroid, pregabalin Patients with a history of allergy to the study drug Pregnancy or breastfeeding women Patients with hypertension, cardiac, renal endocrinal diseases uncooperative patients (cant does not administer oral tablet)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Pregabaline<br>Preoperative oral dose of pregabalin for control blood pressure and decrease dose of nitroglycerine consumption | Drug: Pregabalin 150mg<br>* The oral tablet half an hour preoperative 150 milligrams<br>* Other names: Lyrica 150mg;|
| Experimental: Magnesium sulfate<br>Preoperative intravenous dose for control blood pressure and heart rate | Drug: Magnesium Sulfate<br>* Intravenous administration half an hour preoperative 2 grams<br>* Other names: Magnisol 1gm/ 5ml;|
| Experimental: Nitroglycrine<br>Measuring the total dose of nitroglycerine used, using a syringe pump | Drug: Nitroglycerin<br>* measure total dose of nitroglycerine in milligrams using a syringe pump<br>* Other names: Nitronal;Other: surgeon satisfaction<br>* surgeon satisfaction measured according to Likert's scale<br>* Other names: surgeon satisfaction Likert's scale;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Dose of nitroglycerine | total dose measured by a syringe pump | an hour and half | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| quality of surgical field | using Boezaart et al grading scale | an hour and half | 
| surgeon satisfaction | using Likert's scale | an hour and half |