The Physical Activity Post Myocardial Infarction SWEDEHEART Prospective Cohort Study

Study Overview
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Brief Summary
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The association between objectively measured physical activity intensities (light, moderate and vigorous), sedentary time and clinical outcomes has not been clarified in patients after a myocardial infarction. The overall objective of the study is to explore associations between accelerometer measured physical activity and clinical outcomes after a myocardial infarction. Moreover, the association between changes in physical activity and outcomes will be assessed.

Detailed Description
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It is estimated to include 4000 patients with myocardial infarction during 2 years. Patients will wear the accelerometer for 7 days at follow-up visits (2 months and 1 year) after discharge. The investigators will examine the dose-response relations of several exposure variables from the accelerometer measurements with the outcomes.

Official Title
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The Physical Activity Post Myocardial Infarction SWEDEHEART Prospective Cohort Study (ACTIVITY-SWEDEHEART)

Conditions
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Myocardial Infarction

Intervention / Treatment
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* Other: Accelerometer measurement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Signed informed consent Diagnosis of a type 1 myocardial infarction registered in SWEDEHEART Age 18-79 years at discharge from hospital Attending the first visit in the cardiac rehabilitation (CR) registry SEPHIA (2 months after discharge) Exclusion Criteria: Inability to understand Swedish Non-ambulatory Any mental condition that may interfere with the possibility for the patient to comply with the study protocol

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 79 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Cohort group<br>Diagnosis of a type 1 myocardial infarction registered in SWEDEHEART Age 18-79 years at discharge from hospital | Other: Accelerometer measurement<br>* Study personnel will initiate an accelerometer and inform the patient to wear the accelerometer with an elastic belt on their right hip during waking hours for seven consecutive days. Moreover, patients are instructed to register their wear time in an activity diary in paper form. In addition, patients will register their working hours, if relevant. After seven days, patients send back the accelerometer and diary in a pre-paid envelope. The same procedure is repeated at the second follow-up visit at 1 year.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Major adverse cardiovascular event (MACE) | The composite incidence of cardiovascular mortality, non-fatal myocardial infarction, non-fatal ischemic stroke, coronary revascularization, hospitalization for new or worsening heart failure | 1 year after the index cardiac event | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cardiovascular mortality | Incidence of cardiovascular mortality | 1 year after the index cardiac event | 
| Non-fatal myocardial infarction | Incidence of non-fatal myocardial infarction | 1 year after the index cardiac event | 
| Non-fatal ischemic stroke | Incidence of non-fatal ischemic stroke | 1 year after the index cardiac event | 
| Coronary revascularization | Incidence of coronary revascularization | 1 year after the index cardiac event | 
| Heart failure | Incidence of hospitalization for new or worsening heart failure | 1 year after the index cardiac event | 
| Major adverse cardiovascular event (MACE) | The composite incidence of cardiovascular mortality, non-fatal myocardial infarction, non-fatal ischemic stroke, coronary revascularization, hospitalization for new or worsening heart failure | 3 years after the index cardiac event | 
| Cardiovascular mortality | Incidence of cardiovascular mortality | 3 years after the index cardiac event | 
| Non-fatal myocardial infarction | Incidence of non-fatal myocardial infarction | 3 years after the index cardiac event | 
| Non-fatal ischemic stroke | Incidence of non-fatal ischemic stroke | 3 years after the index cardiac event | 
| Coronary revascularization | Incidence of coronary revascularization | 3 years after the index cardiac event | 
| Heart failure | Incidence of hospitalization for new or worsening heart failure | 3 years after the index cardiac event | 
| All-cause death | Incidence of all-cause death | 1 year after the index cardiac event | 
| All-cause death | Incidence of all-cause death | 3 year after the index cardiac event | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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physical activity, Accelerometer, Registry