Cohort of Mexican Children With Diabetes Mellitus (CMC-DM)

Study Overview
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Brief Summary
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The aim of this study is the identification of complications in diabetes mellitus pediatric patients and to compare the clinical, anthropometric, and biochemical characteristics between children in the different types of diabetes mellitus.

Detailed Description
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Diabetes mellitus is characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin resistance in target tissues. This study identify the influence of pathogenic factors on the evolution of diabetes mellitus and in the presence of chronic complications.

Official Title
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Characteristics and Evolution of Diabetes Mellitus in Mexican Children: Cohort Study

Conditions
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Diabetes Mellitus

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with confirmed diagnosis of diabetes mellitus Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 1 Month
Maximum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Type 1 diabetes mellitus<br>Sudden onset of symptoms and non-overweight/obese | |
| Type 2 diabetes mellitus<br>Insidious onset of symptoms and overweight/obese | |
| Type 1.5 diabetes mellitus<br>Overlap of type 1 and type2 diabetes mellitus clinical characteristics | |
| Other types of diabetes mellitus<br>According American Diabetes Association criteria | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Diabetic retinopathy | A microvascular complication determined by ophthalmological evaluation | year 3 | 
| Peripheral diabetic neuropathy | A microvascular complication determined by neurological exam in either foot | year 5 | 
| Nerve damage | A microvascular complication determined by nerve conduction study in either foot | year 5 | 
| Microalbuminuria | A microvascular complication determined by urine albumin excretion >= 30 mg/day | annual | 
| Cardiac function | A cardiovascular risk indicator determined by echocardiogram | year 5 | 
| Cognitive evaluation | Determined by scores on the Mini-Mental State Examination | year 3 | 
| Intelligence quotient evaluation | Determined by Intelligence quotient test | year 3 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body composition | Determined by body mass index (BMI) percentiles computed from physical measurements of height and weight and corresponding percentile tables | annual | 
| Glycemic control | Determined by HbA1c | annual | 
| Beta cell function | Determined by fasting C peptide | annual | 
| Pancreatic autoimmunity | Determined by pancreas autoantibodies | onset of diabetes | 
| Insulin resistance | Determined by insulin sensitivity | annual | 
| Alpha cell function | Determined by glucagon | year 5 | 
| Hyperlipidemia | Determined by lipid profile | annual | 
| Hypothyroidism | Determined by thyroid profile | annual | 
| Hypertension | Determined by collection of systolic and diastolic blood pressure and calculation of their percentile values | annual | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Pediatrics