Absorption Kinetics and Efficacy of Vitamin D Enriched Supplements in Older Adults.

Study Overview
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Brief Summary
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The proposed study will examine vitamin D bioavailability when 20µg of vitamin D is consumed in 5 different forms: i) a vitamin D enriched pre-formed mixed micelle dairy drink ii) a vitamin D enriched olive oil dairy drink iii) a vitamin D enriched fish oil dairy drink iv) a vitamin D enriched fat-free dairy drink

Detailed Description
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This postprandial study will recruit healthy males and females aged 18 and over. Upon completion of informed consent procedures and successful screening, the volunteers will complete 4 study visits. Participants will consume a standardised meal the evening before each test day, and will arrive in the morning to the research facility in UCD after an overnight fast of 12 hours. On the study test days, volunteers will be given one of the following vitamin D treatments in a dairy drink, followed by a low-fat breakfast. mixed micelles olive oil fish oil fat-free Participants will also be given a low-fat lunch 5 hours after the supplement is consumed. Volunteers will be cannulated by a trained phlebotomist on arrival, and a fasting blood sample will be taken. Following ingestion of the vitamin D supplements blood samples will be taken at 0,2,4,6, and 8 hours post ingestion. A 10mL sample will be collected at each time point. In total, 60mL of blood will be collected over 24 hours. The participant's food intake will be recorded during the visit.

Official Title
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Absorption Kinetics and Efficacy of Vitamin D Enriched Supplements in Older Adults.

Conditions
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Vitamin D Deficiency

Intervention / Treatment
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* Dietary Supplement: Vitamin D supplement


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Healthy men and women Exclusion Criteria: Pregnant or lactating Smokers Individuals that are not free-living e.g. institutes where meals are prepared in bulk such as nursing homes, prisons etc. An inability to read, write or understand English Following a strict prescribed diet for any reason, insulin dependent diabetes, coeliac disease, Crohn's disease Disease or condition that requires chronic therapeutic nutritional or medical treatment. Those taking supplemental vitamin D Those who have been on a sun holiday in the last 2 months

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: The is a 4 arm single-blinded crossover study
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Vitamin D enriched mixed micelles dairy drink<br>20ug vitamin D in pre-formed mixed micelle dairy drink | Dietary Supplement: Vitamin D supplement<br>* This intervention will compare the effect of changing the lipid component of a vitamin D enriched dairy drink on postprandial change in 25OHD concentrations.<br>|
| Active Comparator: Vitamin D enriched olive oil dairy drink<br>20ug vitamin D in olive oil dairy drink | Dietary Supplement: Vitamin D supplement<br>* This intervention will compare the effect of changing the lipid component of a vitamin D enriched dairy drink on postprandial change in 25OHD concentrations.<br>|
| Active Comparator: Vitamin D enriched fish oil dairy drink<br>20ug vitamin D in fish oil dairy drink | Dietary Supplement: Vitamin D supplement<br>* This intervention will compare the effect of changing the lipid component of a vitamin D enriched dairy drink on postprandial change in 25OHD concentrations.<br>|
| Active Comparator: Vitamin D enriched fat-free dairy drink<br>20ug vitamin D in fat-free dairy drink | Dietary Supplement: Vitamin D supplement<br>* This intervention will compare the effect of changing the lipid component of a vitamin D enriched dairy drink on postprandial change in 25OHD concentrations.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in 25-hydroxyvitamin D (25(OH)D) | Change in 25(OH)D up to 8 hours after consuming the vitamin D enriched dairy drink | 8 hours |