Efficacy of Pectoral Nerve Block for Breast Reduction Surgery

Study Overview
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Brief Summary
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The purpose of the study is to evaluate the efficacy of PECS block applied to patients undergoing bilateral breast reduction surgery on postoperative analgesia compared to local infiltration anesthesia.

Detailed Description
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Pectoral nerve block (PECS block) has been developed as an alternative to thoracic paravertebral and/or thoracic epidural blocks in recent years. It is frequently applied for postoperative analgesia especially in breast cancer surgery and subpectoral breast prosthesis.

Official Title
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Comparison of The Effects of Pectoral Nerve Block and Local Infiltration Anesthesia on Postoperative Analgesia for Breast Reduction Surgery

Conditions
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Nerve Blocks, Breast Surgery, Postoperative Pain

Intervention / Treatment
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* Procedure: PECS group
* Procedure: Control group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Society of Anesthesiology (ASA) I-II body mass index (BMI) ≤40 kg/m2 elective bilateral breast reduction surgery Exclusion Criteria: declining to give written informed consent ASA III and above under 18 years of age or over 65 years of age history of allergy against to the local anesthetics, controendication of peripheral block or local anesthetic infiltration (local infection, coagulopathy, etc.) history of breast surgery treatment due to psychiatric disorder history of treatment for a chronic pain history of nerve blocks in order to treat postoperative pain

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| PECS group<br>Preoperative bilateral PECS I + PECS II Pecs block performed by anaesthetist using ultrasound guidance in plane approach | Procedure: PECS group<br>* Pecs block performed using ultrasound guidance<br>* Other names: Regional anesthesia in breast surgery;|
| Control group<br>Bilateral local anesthesia infiltration Local infiltration anesthesia performed by surgeon during the operation | Procedure: Control group<br>* Local infiltration anesthesia performed during the operation<br>* Other names: Regional anesthesia in breast surgery;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| postoperative visual analog scale (VAS) score | Postoperative pain assessment will be performed using the VAS score (VAS 0 = no pain, VAS 10 = most severe pain possible). The VAS scores will be recorded at postoperative 0, 1, 3, 6, 9, and 12 hours. | postoperative 0, 1, 3, 6, 9, and 12 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| analgesia consumption | postoperative | 12 hours | 
| length of hospital | recorded at the following time after surgery | 4 days | 
| analgesia consumption | intraoperative | during the surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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pectoral nerve block (PECS block), breast reduction surgery, ultrasonography, postoperative pain, VAS score