Epidemiological Study on the Relationship Between Respiratory Health and Air Pollution From Industrial Sources

Study Overview
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Brief Summary
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The ELISABET STUDY is across sectional Survey on a representative sample of two urban area conduct on a representative sample. The main objective of the project is to compare the prevalence of the obstructive ventilatory disorders (OVD) in the Urban Community of Dunkirk touched by the industrial pollution in relation to the one recovered in the Urban Community of Lille (CUDL) less industrialized.

Detailed Description
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Airflow obstruction include Pulmonary Disease, Chronic Obstruction and asthma. Identification of Airflow obstruction is through Functional Tests Lung. In the 1950s, high pollution levels were associated with increased mortality. Despite a reduction of air pollution, it has been established that pollution peaks have short-term effects on acute respiratory episodes. The Urban Community of Dunkirk (CUD) focuses many large pollutant emitters. The long term effects of industrial pollution on TVO are unknown. The main objective of the project is to compare the prevalence of Airflow obstruction in the Urban Community of Dunkirk affected by industrial pollution compared to that found in the Urban Community of Lille (CUDL) less industrialized. Secondary objectives are: 1) To assess the relationship between air pollution from industrial and biological markers, particularly the plasma concentrations of heavy metals 2) To assess the prevalence of TVO general population in French populations 3) Establish a baseline epidemiological and biological bank.

Official Title
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ELISABET : Enquête LIttoral Souffle Air Biologie Environnement

Conditions
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Airway Obstruction, Hypertension, Diabetes Mellitus, Dyslipidemias, Pulmonary Disease, Chronic Obstructive

Intervention / Treatment
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* Other: heteroevaluation scale by a nurse or doctor


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: had lived for at least 5 years in the same city or its surrounding urban area (either Lille or Dunkirk) in the northern of France Agreed to participate and signed contentment Exclusion Criteria: The detainees People under legal protection Individuals unable to consent

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 64 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Dunkirk area<br>Representative sample of Dunkirk and the surrounding urban area (of  200 000inhabitants).Dunkirk area is characterize by high emission of industrial air pollutant | Other: heteroevaluation scale by a nurse or doctor<br> <br> |
| Lille area<br>Representative sample of Lille and the surrounding urban area (of  1 million inhabitants, the fourth urban area in France) | Other: heteroevaluation scale by a nurse or doctor<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| airway obstruction | Forced expiratory volume per second (FEV1) to forced vital capacity (FVC) ratio below 0.7. mesured by standardized spirometry Spirometry testing was performed mostly at home using Micro 6000 spirometers (Medisoft; Sorinnes, Belgium), according to the 2005 ATS/ERS guidelines. The spirometers were calibrated weekly. No bronchodilators were administered. For each participant, the spirometry test was repeated (up to seven times) until three acceptable, reproducible flow-volume loops were obtained, following the same guidelines. The greatest reproducible values of FEV1 and FVC were selected for the statistical analysis (regardless of whether these two values came from separate curves or from the same curve). All spirometry data were validated by an experienced, specialist physician. | during a the single visit scheduled (less than 3 hours in the morning) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| hypertension | Hypertension was defined as ongoing antihypertensive treatment, an Systolic blood pressure >=140 mmHg or a Diastolic Blood pressure >=90 mmHg | during a the single visit scheduled (less than 3 hours in the morning) | 
| dyslipidemia | Dyslipidemia was defined as ongoing cholesterol-lowering treatment or one or more abnormal fasting blood lipid values (total cholesterol 2.4 g/L, LDLcholesterol>=1.6 g/L, HDLcholesterol <0.4 g/L or blood triglycerides >=2 g/L) | during a the single visit scheduled (less than 3 hours in the morning) | 
| diabetes mellitus | Diabetes mellitus was defined as ongoing antidiabetes treatment (oral medication or insulin) or a fasting blood glucose (FBG) level >=1.26 g/L | during a the single visit scheduled (less than 3 hours in the morning) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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air pollution, epidemiological survey, representative sample