Quality of Life in Barrett's Esophagus and Gastro-Esophageal Reflux Disease

Study Overview
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Brief Summary
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To Compare the overall quality of life of patients with no Barrett's esophagus , non-dysplastic Barrett's Esophagus (NDBE), Barrett's esophagus with low grade dysplasia (LGD), and Barrett's esophagus with high grade dysplasia (HGD). We also Compare the overall quality of life of Barrett's esophagus patients with severe gastroesophageal reflux disease (GERD) symptoms to those with no GERD symptoms

Detailed Description
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The presence of GERD symptoms is associated with a significant decrease in quality of life.While a diagnosis of Barrett's esophagus is also associated with a decrease in quality of life, these studies evaluated Barrett's esophagus patients with GERD symptoms.It is unclear whether decrements in quality of life from cancer risk in patients with Barrett's esophagus are due to actual cancer risk or a patient's false perception.Here we Compare the overall quality of life of patients with no Barrett's esophagus , non-dysplastic Barrett's Esophagus (NDBE), Barrett's esophagus with low grade dysplasia (LGD), and Barrett's esophagus with high grade dysplasia (HGD). The Investigators will also Compare the overall quality of life of Barrett's esophagus patients with severe gastroesophageal reflux disease (GERD) symptoms to those with no GERD symptoms. Finally the investigators will compare the overall quality of life of patients with a perceived low risk of esophageal cancer to those with a perceived high risk of esophageal cancer

Official Title
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Quality of Life in Barrett's Esophagus and GERD:GERD Symptoms, Perception of Cancer Risk, and Actual Cancer Risk

Conditions
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Barrett's Esophagus, Gastroesophageal Reflux Disease

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 or above At least one of the following: Previous diagnosis of Barrett's esophagus Presence of GERD symptoms per patient report Exclusion Criteria: None

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Barrett's esophagus<br>Subject without columnar lined esophagus | |
| Nondysplastic BE<br>Subject with columnar lined esophagus and absence of dysplasia | |
| Low grade dysplastic BE<br>subject with columnar lined esophagus and presence of low grade dysplasia | |
| High grade dysplastic BE<br>subject with columnar lined esophagus and presence of high grade dysplasia | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health State Utility as measured by the Time Trade-off (TTO) method/Standard Gamble (SG) method | questionnaire | 1 year | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| SF-36 physical function (PF) subscale | questionnaire | 12 months | 
| SF-36 role limitations-physical (RP) subscale | questionnaire | 12 months | 
| SF-36 general health (GH) subscale | questionnaire | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Barrett's esophagus, Gastroesophageal reflux disease, Quality of life