Contrast Medium Volume and Contrast-induced Nephropathy After Percutaneous Coronary Intervention

Study Overview
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Brief Summary
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To investigate the predictive value of the contrast media volume to creatinine clearance (V/CrCl) ratio for the risk of contrast-induced nephropathy (CIN) (i.e., within 48-72 h) and to determine a relatively safe V/CrCl cut-off value to avoid CIN in patients following PCI

Detailed Description
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contrast media volume to creatinine clearance (V/CrCl) ratios were obtained from consecutive consenting patients after unselective PCI. Receiver-operator characteristic (ROC) curves were used to identify the optimal sensitivity for the observed range of V/CrCl. The predictive value of V/CrCl for the risk of CIN was assessed using multivariate logistic regression.

Official Title
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Contrast Medium Volume and Contrast-induced Nephropathy After Percutaneous Coronary Intervention

Conditions
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Contrast Induced Nephropathy

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients who agreed to stay in the hospital for 2-3 days after percutaneous coronary intervention provided written informed consent Creatinine Clearance:15-60ml/min Exclusion Criteria: pregnancy lactation intravascular administration of an contrast medium within the previous seven days treatment with metformin aminoglycosides N-acetylcysteine (NAC) nonsteroidal anti-inflammatory drugs within the previous 48 h intake of nephrotoxic drugs within the previous seven days history of serious reactions to contrast mediums severe concomitant disease renal transplantation , or end-stage renal disease necessitating dialysis patients who died during percutaneous coronary intervention

Ages Eligible for Study
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Minimum Age: 21 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| percutaneous coronary intervention<br>The investigators reviewed all consecutive patients who were undergoing percutaneous coronary intervention | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Contrast-Induced Nephropathy | Contrast-Induced Nephropathy was defined as an increase in serum creatinine of more than 0.5 mg/dl from the baseline within 48-72 h of contrast exposure | 48-72 h | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Major adverse clinical events | Major adverse clinical events: death, requiring renal replacement therapy, 2nd myocardial infarction,target revascularization,acute heart failure, mechanical ventilation,2nd angina,tachyarrhythmia,hypotension,intra-aortic balloon pump and stroke | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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contrast-induced nephropathy, contrast medium, creatinine clearance, percutaneous coronary intervention