Study Examining the Effect of Exercise in People With Rheumatoid Arthritis Taking Anti-TNFalpha Medication

Study Overview
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Brief Summary
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The purpose of this study is to determine whether exercise is beneficial for people with rheumatoid arthritis(RA) taking antiTNFalpha medication

Detailed Description
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Substantial progress has been made in the medical management of RA over the past decade but at present no drug therapy leads to long-term remission for all patients with RA. People may still continue to experience physical, psychological and functional consequences which could benefit from rehabilitation.little research exists on the effects of exercise for people with RA taking anti-TNFalpha therapy medication. It is proposed to conduct a randomized controlled trial to examine the effects of group exercise therapy in a gym setting or in a hydrotherapy pool compared to a control group.

Official Title
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Randomized Controlled Trial Examining The Effect Of Exercise In People With Rheumatoid Arthritis Taking Anti-TNFalpha Medication

Conditions
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Arthritis, Rheumatoid

Intervention / Treatment
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* Other: Gym exercise group intervention
* Other: Hydrotherapy group exercise intervention
* Other: Control group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients with RA receiving anti-TNFalpha therapy medication for more than three months Consenting male and female patients aged 18 - 70 years Patients will have a documented diagnosis of RA as classified by the American College of Rheumatology (ACR) criteria ACR functional class I, II, III Exclusion Criteria: Patients who have attended physiotherapy in the past three months Patients to whom exercise therapy or hydrotherapy are contraindicated Patients who have undergone joint surgery in the past six months

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: 1<br>Gym group exercise intervention | Other: Gym exercise group intervention<br>* Gym based circuit class<br>* Other names: Gym Group;|
| Experimental: 2<br>Hydrotherapy group exercise intervention | Other: Hydrotherapy group exercise intervention<br>* Hydrotherapy group exercise class<br>* Other names: Aquatic Physiotherapy;|
| No Intervention: 3<br>Control group | Other: Control group<br>* No intervention<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Stanford Health Assessment Questionnaire |  | Baseline, 8 weeks and 24 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 50 foot Walk Test |  | Baseline, 8 weeks and 24 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Arthritis, Rheumatoid, Exercise, Biological Therapy