Recovery of Patients From COVID-19 After Critical Illness

Study Overview
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Brief Summary
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Patients who are critically ill with COVID-19 requiring life support in an intensive care unit (ICU) have increased risk of morbidity and mortality. Currently the ICU community does not know what effect the disease, the ICU admission, physiotherapy interventions and life support have on their long-term quality of life and whether they can return to their pre-illness level of function following ICU. COVID-Recovery will describe the physiotherapy interventions delivered to critically ill patients with COVID-19. In survivors, COVID-Recovery will utilise telephone follow-up of ICU survivors to assess disability-free survival and quality of life at 6 months after ICU admission. Additionally, COVID-Recovery will identify if there are predictors of disability-free survival. COVID-Recovery will aim to select up to 300 patients diagnosed with COVID-19 from ICUs in Australia. If they survive to hospital discharge, patients will be invited to receive a telephone questionnaire at 6 months after the ICU admission that aims to assess their long-term outcomes, including physical, cognitive and emotional function, quality of life, and whether they have been able to return to work following ICU discharge. To describe the experience of critical illness in survivors of COVID-19 and their family members. To explore and describe functional recovery, respiratory system function and respiratory health morbidity up to 6 months after ICU admission in persistently critically ill adults with COVID-19

Official Title
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The Coronavirus Disease 2019 - Recovery Study

Conditions
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COVID-19, Critical Illness

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: COVID-19 patients who have been admitted to ICU for > 24 hours Patients aged over 17 years Persistent critical illness cohort As above An ICU admission of at least 10 consecutive days Exclusion Criteria: Previous enrolment in this study in a prior ICU admission

Ages Eligible for Study
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Minimum Age: 17 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Disability-free survival | a composite measure of WHODAS 2.0 - 12 level and hospital survival | 6 months | 
| Physiotherapy intervention | The physiotherapy interventions provided to patients with COVID-19 admitted to the ICU and health outcomes | During the ICU stay until 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Health status | Health related quality of life measured with EQ5D-5L score from 0 to 100 | 6 months | 
| Global function | World Health Organization Disability Assessment Schedule 2.0 12L | 6 months | 
| Cognitive function | Montreal Cognitive Assessment Blind | 6 months | 
| Anxiety and depression | Hospital Anxiety and Depression Scale | 6 months | 
| Screening for post-traumatic distress | Impact of Events Scale Revised | 6 months | 
| Work Status | WHODAS 2.0 | 6 months | 
| Proportion of patients with COVID-19 who received physiotherapy in ICU |  | During the ICU stay until 28 days | 
| The reported barriers to delivering physiotherapy interventions | Physiotherapist reported barriers to delivering the intervention | During the ICU stay until 28 days | 
| Adverse events during physiotherapy interventions | Adverse events that require the intervention to be ceased for medical intervention | During the ICU stay until 28 days | 
| Phenomenological data of the patient and family experience | Qualitative interviews | 6 months | 
| Global function | Global Rating of Change | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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recovery