Axis Length and Its Relationship With Refractive Error in Chinese University Students

Study Overview
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Brief Summary
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To investigate the relationship between axis length (AL) and refractive error. eyes of low hyperopia to emmetropia subjects, comprising eyes with moderate to high myopia (-11.00D ≤ SE ≤ -4.00D) were analyzed in this cross-sectional study. Cycloplegic refractive error was measured with the autorefractor, AL was measured with the IOL master. Association between AL and refractive error were evaluated by linear regression analysis. The mean of AL and its correlation with SE, sex, and age were evaluated.

Detailed Description
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To investigate the relationship between axis length (AL) and refractive error (RE). 894 eyes with low hyperopia to emmetropia (-0.50D ≤ spherical equivalent (SE) ≤ +2.00D), comprising 1007 eyes with moderate to high myopia (-11.00D ≤ SE ≤ -4.00D) were analyzed in this study. Cycloplegic RE was measured with the autorefractor, AL was measured with the IOL master. Association between AL and refractive error were evaluated by linear regression analysis. The mean of AL and its correlation with SE, sex, and age were evaluated.

Official Title
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Shanghai Guanghua Integrated Traditional Chinese and Western Medicine Hospital, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

Conditions
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Refractive Error - Myopia Axial

Intervention / Treatment
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* Other: myopia or not myopia


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: with moderate to high myopia (SE ≤ -4.00D) without myopia (-0.50D ≤ spherical power ≤ +2.00D) no concurrent eye disease best corrected visual acuity is 1.0 Exclusion Criteria: significant systemic illnesses congenital myopia, media opacity uveitis glaucoma intraocular surgery refractive surgery neurologic diseases retinal disease

Ages Eligible for Study
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Minimum Age: 22 Years
Maximum Age: 26 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| axis length<br>1007 healthy students with moderate to high myopia (SE ≤ -4.00D) and 894 without myopia (-0.50D ≤ spherical power ≤ +2.00D) were enrolled. | Other: myopia or not myopia<br>* visual acuity, IOL master biometry, the anterior segment with slit lamp, dilated fundus examination and refraction.<br>|
| gender<br>male were 54.29% (N=1032), and female were 45.71% (N=869) | Other: myopia or not myopia<br>* visual acuity, IOL master biometry, the anterior segment with slit lamp, dilated fundus examination and refraction.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Axis length | Axis length change from baseline at 6 months | from baseline at 6 months | 
| Refractive Error | Refractive Error change from baseline at 6 months | from baseline at 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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China, high myopia, hyperopia, emmetropia