Autoimmune Phenomena After Acute Stroke

Study Overview
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Brief Summary
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The damage of the brain parenchyma, as well as the stroke-induced dysfunction of the blood-brain-barrier can make previously hidden CNS antigens visible, and can thus lead to the development of autoimmune mechanisms. It seems plausible that stroke-associated immunodepression influences the development and the phenotype of these autoreactive immune responses. This study will investigate whether cerebral ischemia leads to changes in the immune response, in particular to the development and/or proliferation of autoreactive effector T-cells and/or regulatory T-cells. Furthermore, the association between the severity and the phenotype of this autoimmune response and the clinical course, i.e. prognosis and mortality, will be investigated.

Official Title
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Autoimmune Phenomena After Acute Stroke - the Role of Stroke-induced Immunodepression

Conditions
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Stroke

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: acute media infarct or intracerebral bleeding within the last 36 h (patients) NIHSS > 7 (patients) age > 17 years (patients), age > 54 years (controls) informed consent of patient or legal representative/ of control cardiovascular risk such as diabetes mellitus (control) Exclusion Criteria: infections (patients, controls) antibiotic or immunosuppressive treatment within the last 4 weeks (patients) other CNS disorders

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| patients with acute media infarct<br> | |
| controls with cardiovascular risks<br> | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| autoantigen-specific T-cells in patients with acute media infarct | quantitative determination of autoantigen-specific T-cells in patients with acute media infarct | within 36 h | 
| leukocytes in patients with acute media infarct | quantitative and qualitative analysis of leukocytes in patients with acute media infarct | within 36 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| frequency and phenotype of CNS-autoreactive immune cells under the influence of immunodepression |  | within 36 h, after day 3, 7, 90 and 180 | 
| clinical course, i.e. mortality and prognosis (measured by mod. Rankin Scale) |  | after day 90 and 180 | 
| clinical course, i.e. mortality and prognosis (measured by Bartel Index) |  | after day 90 and 180 | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stroke-induced immunodepression, acute media infarct, acute intracerebral bleeding, leucocytes, autoaggressive T-cells, acute media infarct or acute intracerebral bleeding