Postprandial Effects of Functional Bread

Study Overview
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Brief Summary
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This study investigates whether bread with added galactomannan, a soluble fiber, can reduce the postprandial glucose response in healthy overweight adults.

Detailed Description
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This single-blind crossover-designed study wants to investigate the postprandial effect of functional bread in healthy overweight adults. Therefore, four types of bread, consumed by the participants, have added galactomannan in different amounts and viscosities, and one bread is the control bread. The participants arrive after an overnight fast and before the consumption of bread, a fasting blood sample is taken. After the ingestion, blood samples are taken at specific times. The area under the curve of the postprandial glucose is expected to differ between the functional breads.

Official Title
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Postprandial Effects of Functional Bread

Conditions
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Postprandial Hyperglycemia

Intervention / Treatment
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* Dietary Supplement: Functional bread


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy, overweight adults (BMI between 25 and 30 kg/m2) Exclusion Criteria: Known diagnosis of diabetes mellitus type 2 HbA1c at screening ≥ 48 mmol/mol Other chronic diseases (heart disease, cancer) within the last 3 years Pregnancy and lactation Known drug or alcohol abuse Unwilling to follow the study requirements

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Placebo Comparator: Control Bread<br>no added guar gum | Dietary Supplement: Functional bread<br>* Postprandial effects of bread containing galactomannan<br>|
| Active Comparator: Functional Bread 1<br>10% guar gum, low molecular weight | Dietary Supplement: Functional bread<br>* Postprandial effects of bread containing galactomannan<br>|
| Active Comparator: functional Bread 2<br>10% guar gum, high molecular weight | Dietary Supplement: Functional bread<br>* Postprandial effects of bread containing galactomannan<br>|
| Active Comparator: Functional Bread 3<br>15% guar gum, low molecular weight | Dietary Supplement: Functional bread<br>* Postprandial effects of bread containing galactomannan<br>|
| Active Comparator: Functional Bread 4<br>15% guar gum, high molecular weight | Dietary Supplement: Functional bread<br>* Postprandial effects of bread containing galactomannan<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| area under the curve of postprandial glucose |  | 180 minutes | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| area under the curve postprandial insulin |  | 180 minutes |