Academic Detailing About Proton Pump Inhibitors

Study Overview
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Brief Summary
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General practices in the Capital Region of Denmark are offered a short educational visit and are randomized to either proton pump inhibitor (intervention) or another topic (control). The change in prescription pattern from before to after the visit is compared between the intervention and control group.

Detailed Description
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General practices in the Capital Region of Denmark are offered a short educational visit. They are randomized by address to be offered a visit about either proton pump inhibitor (intervention) or another topic (control). The prescription pattern of each general practice (as seen by their regional registration number [ydernummer]) who receive a visit is investigated. The change in prescription pattern from before to after the visit is compared between the intervention and control group.

Official Title
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Boosting General Practice pRescription by Individual Educational Fast Academic Detailing Visits About Proton Pump Inhibitor

Conditions
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Prescription Pattern

Intervention / Treatment
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* Behavioral: Proton pump inhibitor education
* Behavioral: Other education


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: General practices in the Capital Region of Denmark, who owns a regional registration number [ydernummer] Want a visit Have time for a visit within the study period Exclusion Criteria: -
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: randomized placebo controlled study
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Proton pump inhibitor education<br>The general practices in this arm will receive the education visits about Proton pump inhibitor. | Behavioral: Proton pump inhibitor education<br>* A 15 minutes (preferable) one-on-one educational visit about deprescription of proton pump inhibitor<br>|
| Placebo Comparator: Other education<br>The general practices in this arm will receive an educational visit on another topic (asthma). | Behavioral: Other education<br>* A 15 minutes (preferable) one-on-one educational visit about another topic (NOT asthma).<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in change of number of adult patients with redeemed prescriptions on proton pump inhibitor between asthma-group and placebo-group in a six months period | Difference in change of number of adult patients with redeemed prescriptions on proton pump inhibitor between asthma-group and placebo-group | 6-0 months before and 6-12 months after educational visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Difference in change of number of adult patients with redeemed prescriptions on proton pump inhibitor between asthma-group and placebo-group in a one year period | Difference in change of number of adult patients with redeemed prescriptions on proton pump inhibitor between asthma-group and placebo-group | one year before and one year after educational visit | 
| Difference in change of number of adult patients with redeemed prescriptions on proton pump inhibitor between asthma-group and placebo-group in a one year perioid as interrupted time series analysis | Difference in change of number of adult patients with redeemed prescriptions on proton pump inhibitor between asthma-group and placebo-group as interrupted time series analysis | one year before and one year after educational visit | 
| Difference in change of number of adult patients with redeemed prescriptions on proton pump inhibitor between asthma-group and placebo-group analyzed by each month in relation to the visit in one year | Difference in change of number of adult patients with redeemed prescriptions on proton pump inhibitor between asthma-group and placebo-group analyzed by each month in relation to the visit | one year before and one year after educational visit | 
| Difference in change of prescription (DDD) of PPI before and after educational visit in a six months period | Difference in change of defined daily dosages (DDD) of proton pump inhibitor to adult patients between asthma-group and placebo-group | 6-0 months before and 6-12 months after educational visit | 
| Difference in change of prescription (DDD) of PPI before and after educational visit in one year | Difference in change of defined daily dosages (DDD) of proton pump inhibitor to adult patients between asthma-group and placebo-group | one year before and one year after educational visit | 
| Difference in change of prescription (DDD) of PPI before and after educational visit in one year as interrupted time series analysis | Difference in change of defined daily dosages (DDD) of proton pump inhibitor to adult patients between asthma-group and placebo-group as interrupted time series analysis | one year before and one year after educational visit | 
| Difference in change of prescription (DDD) of PPI before and after educational visit in one year for each month | Difference in change of defined daily dosages (DDD) of proton pump inhibitor to adult patients between asthma-group and placebo-group analyzed by each month in relation to the visit | one year before and one year after educational visit | 
| Difference in change of prescription (DDD) of antacid before and after educational visit in a six months period | Difference in change of defined daily dosages (DDD) of antacid to adult patients between asthma-group and placebo-group | 6-0 months before and 6-12 months after educational visit | 
| Difference in change of prescription (DDD) of antacid before and after educational visit in one year | Difference in change of defined daily dosages (DDD) of antacid to adult patients between asthma-group and placebo-group | one year before and one year after educational visit | 
| Difference in change of prescription (DDD) of antacid before and after educational visit in one year as interrupted time series analysis | Difference in change of defined daily dosages (DDD) of antacid to adult patients between asthma-group and placebo-group as interrupted time series analysis | one year before and one year after educational visit | 
| Difference in change of prescription (DDD) of antacid before and after educational visit in one year for each month | Difference in change of defined daily dosages (DDD) of antacid to adult patients between asthma-group and placebo-group analyzed by each month in relation to the visit | one year before and one year after educational visit | 
| Difference in change of numbers of big packages of PPI before and after educational visit in a six months period | Difference in change numbers of big packages (90 pcs or more) of PPI in highest dosage strength to adult patients between asthma-group and placebo-group | 6-0 months before and 6-12 months after educational visit | 
| Difference in change of numbers of big packages of PPI before and after educational visit in one year | Difference in change numbers of big packages (90 pcs or more) of PPI in highest dosage strength to adult patients between asthma-group and placebo-group | one year before and one year after educational visit | 
| Difference in change of numbers of big packages of PPI before and after educational visit in one year as interrupted time series analysis | Difference in change numbers of big packages (90 pcs or more) of PPI in highest dosage strength to adult patients between asthma-group and placebo-group as interrupted time series analysis | one year before and one year after educational visit | 
| Difference in change of numbers of big packages of PPI before and after educational visit in one year for each month | Difference in change numbers of big packages (90 pcs or more) of PPI in highest dosage strength to adult patients between asthma-group and placebo-group analyzed by each month in relation to the visit | one year before and one year after educational visit |