Treatment of Vitiligo With Low-energy Visible Light Laser

Study Overview
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Brief Summary
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The purpose of this study is the evaluate the efficacy of using a low-energy 635 nm visible light laser in the treatment of various recalcitrant forms of vitiligo.

Detailed Description
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Vitiligo is a pigmentary disorder characterized by depigmented and hypopigmented macules and patches. There are forms of vitiligo which are more resistant to treatment, including segmental vitiligo and acral vitiligo. Previous studies have shown that a low energy helium-neon (633 nm) laser can cause increased proliferation of melanocytes and repigmentation in segmental-type vitiligo. The goal of this study is to verify these results and show efficacy in other recalcitrant forms of vitiligo including acral vitiligo and post melanocyte-keratinocyte transplantation vitiligo.

Official Title
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Treatment of Recalcitrant Forms of Vitiligo With a Low-energy 635 nm Visible Light Laser

Conditions
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Vitiligo

Intervention / Treatment
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* Procedure: Laser treatment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Be at least 18 years old Have active or stable segmental vitiligo on the neck or face, acral vitiligo, or have undergone recent melanocyte-keratinocyte transplantation procedure (MKTP) Agree to abide by the Investigator's guidelines regarding photosensitizing drugs and photoprotection Be able to understand the requirements of the study, the risks involved, and be able to sign the informed consent form Agree to follow and undergo all study-related procedures Exclusion Criteria: Women who are lactating, pregnant, or planning to become pregnant Patients with a recent history of melasma, and other disorders of pigmentation with the exception of post inflammatory hyperpigmentation Patients with a known history of photosensitivity disorders Photosensitizing medications may be continued throughout of the study at the discretion of the investigator Patients with a known history of melanoma or non-melanoma skin cancers Concomitant use of tanning beds Any reason the investigator feels the patient should not participate in the study

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Laser treatment<br> | Procedure: Laser treatment<br>* Laser treatment of using 635 nm laser with a dose of 3.0 J/cm^2 to small area (2cm x 2cm) of vitiligo once to twice a week for a total of 12 weeks.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Percent repigmentation |  | 24 clinic visits over 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Vitiligo, Laser, Segmental vitiligo, Acral vitiligo