Aquacel Versus Iodoform Gauze for Filling Abscess Cavity Following Incision and Drainage

Study Overview
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Brief Summary
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This study compares Aquacel against routine Iodoform packing for packing abscess cavities after incision and drainage. It is hypothesized that Aquacel will produce speedier healing of the abscess.

Detailed Description
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The large increase in the incidence of skin and soft tissue infections cause by methicillin resistant staphylococcus aureus (MRSA) has produced a corresponding increase in the number of ED patients presenting with abscesses that require incision and drainage. This study compares Aquacel against routine Iodoform packing for packing abscess cavities after incision and drainage. It is hypothesized that Aquacel will produce speedier healing of the abscess. More effective abscess healing will reduce the need for oral antibiotic coverage, which will in turn reduce the potential for drug resistance caused by indiscriminate use of oral antibiotics.

Official Title
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Aquacel vs. Iodoform Gauze for Filling Abscess Cavity Following Incision and Drainage: A Randomized Control Study

Conditions
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Abscess, Cellulitis

Intervention / Treatment
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* Device: Type of dressing - Iodoform
* Device: Type of dressing - Aquacel


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: presenting to Maricopa Medical Center ED with cutaneous abscess requiring incision and drainage Exclusion Criteria: known sensitivity to Aquacel pregnant, nursing, or expecting to become pregnant incarcerated patient prior treatment of same abscess with incision and drainage multiple abscesses immunodeficiency facial abscess suspected osteomyelitis or septic arthritis diabetic foot, decubitis, or ischaemic ulcers unable to provide informed consent or assent

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: Aquacel vs. Iodoform Gauze
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Iodoform dressing<br>Iodoform dressing for cutaneous abscess | Device: Type of dressing - Iodoform<br>* Dressing for packing a cutaneous abscess<br>* Other names: Iodoform;|
| Active Comparator: Aquacel dressing<br>Aquacel dressing for cutaneous abscess | Device: Type of dressing - Aquacel<br>* Aquacel dressing<br>* Other names: Aquacel;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants Who Experienced a 30% or Greater Reduction in Surface Area of Abscess | Participants were assessed to see whether or not the surface area of the abscess was reduced by at least 30%, and the number of such participants is reported. | 2 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in Patient Rating of Pain | Change in mean pain score based on patient self-report, using Wong-Baker FACES pain rating scale. Scale ranges from 0 to 5, where 5 means the worst pain possible and 0 means no pain at all. | Baseline and 2 weeks | 
| Number of Participants Who Experienced a 30% or Greater Reduction in Surface Area of Cellulitis. | Participants were assessed to see whether or not the surface area of the cellulitis was reduced by at least 30% and the number of such participants was reported. | 2 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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abscess, MRSA, Aquacel dressing, Iodoform dressing