Effect of Paracetamol, Dexketoprofen Trometamol, Lidocaine Spray, Pethidine and Diclofenac Sodium Application for Pain Relief During Fractional Curettage

Study Overview
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Brief Summary
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Patients frequently experience pain from moderate to severe during gynecologic procedures. This study is a prospective, randomized, placebo-controlled trial and aimed to investigate the analgesic efficacy of preoperative oral dexketoprofen trometamol, intravenous paracetamol, lidocaine spray, pethidine and diclofenac sodium on fractional curettage procedure.

Detailed Description
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A total of 144 mutiparous subjects randomly allocated one of six groups. The first group (control group) consisted of 22 participants and they did not receive any treatment. The second group consisted of 26 participants receiving oral 25 mg dexketoprofen trometamol. The third group consisted of 23 participants receiving 2 puff lidocaine sprays on cervical mucosa. The forth group consisted of 25 participants receiving 100 mg pethidine. The fifth group consisted of 23 participants receiving 1000 mg intravenous paracetamol and the sixth group consisted of 25 participants receiving diclofenac sodium.

Conditions
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Pain and Curettage

Intervention / Treatment
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* Drug: comparison of pain relievers during curattage
* Drug: comparison of pain relievers
* Drug: comparison of pain relievers during curattage
* Drug: comparison of pain relievers during curattage
* Drug: comparison of pain relievers during curattage


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: multiparous participants abnormal uterine bleeding postmenopausal bleeding myoma uteri causing menometrorrhagia cervical polyp tamoxifen treatment for breast cancer adnexial mass Exclusion Criteria: abortions pregnancy primiparity diabetes mellitus tendency to bleed such as thrombocytopenia factor deficiency functional disorders of platelets

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| No Intervention: Control group<br>Control group | |
| Active Comparator: Pain reliever<br>1000 mg paracetamol (Parol 1 g Atabay ilaç Turkey) | Drug: comparison of pain relievers during curattage<br> <br> |
| Active Comparator: Dexketoprofen trometamol<br>25 mg oral Dexofen Atabay ilaç Turkey | Drug: comparison of pain relievers<br> <br> |
| Active Comparator: Lidocaine spray<br>2 puff on cervical mucosa (Xylocain Pump 100 Mg 50 Ml Sprey Astra Zeneca) | Drug: comparison of pain relievers during curattage<br> <br> |
| Active Comparator: pethidine<br>Aldolan 100 mg Liba Laboratuarı İstanbul Turkey | Drug: comparison of pain relievers during curattage<br> <br> |
| Active Comparator: diclofenac sodium<br>Dicloron amp 75 mg Deva İlaç Levent İstanbul/Turkey | Drug: comparison of pain relievers during curattage<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Pain |  | 1 year | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Curettage; analgesia; paracetamol; lidocaine; Dexketoprofen trometamol; pethidine; diclofenac.