Social Cognition in Huntington's Disease: Cognitive Study and Functional and Morphological Imaging

Study Overview
=================
Brief Summary
-----------------
Huntington's disease is a rare genetic neurodegenerative disease. It is accompanied by movement disorders, cognitive and behavioral. The social behavior of patients are changed, affecting interpersonal relationships. Patients with Huntington's disease are described as self-centered, lacking sympathy and empathy and mentally inflexible. These behavioral problems can be a major source of anxiety for patients and their families. These disorders also have a negative impact cognitive and motor symptoms as well as the functional abilities and the quality of life of patients and their entourage. Authors have suggested that these problems could be related inter alia to social cognition disorders. This concept refers to a set of skills and emotional and social experiences that regulate relations between individuals and can explain the behavior of individuals and groups. The objective is to evaluate disorders of social cognition, which may account for behavioral changes in Huntington's disease.

Conditions
-----------------
Huntington's Disease

Intervention / Treatment
-----------------
* Behavioral: neuropsychological test
* Radiation: MRI


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: For all particpipants Patient gave its written consent between 20 and 70 years School level : at least 7 years native language: french For presymptomatic patient Huntington's disease diagnosed with abnormal number of CAG repeats: 36 < nucleotide expansion (CAG) Unified Huntington Disease Rating Scale moteur ≤ 5 For symptomatic patient Huntington's disease diagnosed with abnormal number of CAG repeats: 36 < nucleotide expansion (CAG) Unified Huntington Disease Rating Scale moteur > 5 Exclusion Criteria: No national health insurance affiliation Being under guardianship Meeting brain MRI exclusion criteria (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin, or body, Renal failure, hypersensitivity of Gadolinium) or refusing MRI Pregnant or lactating women Patient with involuntary movement hampering the realization of MRI

Ages Eligible for Study
-----------------
Minimum Age: 20 Years
Maximum Age: 70 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Prevention
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Other: presymptomatic patient<br>patient with Unified Huntington's Disease Rating Scale (UHDRS) < 5 | Behavioral: neuropsychological test<br> <br> Radiation: MRI<br> <br> |
| Other: symptomatic patient<br>patient with Unified Huntington's Disease Rating Scale (UHDRS) > 5 | Behavioral: neuropsychological test<br> <br> Radiation: MRI<br> <br> |
| Other: controls<br>unaffected patient with Huntington's disease | Behavioral: neuropsychological test<br> <br> Radiation: MRI<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| the achievement of social cognition process in Huntington's disease using the total score of the scale 15-TOM |  | 3 months after inclusion |