Efficiency of the Quadratus Lumborum Block for Post-operative Analgesia in Abdominoplasty Surgery

Study Overview
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Brief Summary
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Abdominoplasty is a common surgical procedure in plastic surgery which causes postoperative pain and may delay patients' recovery. Surgery is potentially associated with a number of postoperative complications, whether cardiovascular, respiratory, infectious, thromboembolic, or digestive … Although they do not inevitably lead to a life-threatening prognosis, in many cases these complications delay post-operative recovery. Defined in the 1990s by Professor Henry Kehlet's Danish team, rapid rehabilitation after planned surgery is an approach to overall patient care that aims to rapidly restore previous physical and mental capacities and thus significantly reduce mortality and morbidity. Pain management is at the heart of this program and local anesthesia techniques are at the heart of early rehabilitation programs. Described for just over a decade, Quadratus Lumborum Block (QLB) have shown their effectiveness for analgesia in abdominal, or orthopedic, or obstetrical surgery. Considering the anatomical territory concerned, this locoregional anesthesia technique seems to be very interesting in abdominoplasty to allow early rehabilitation of the patient.

Official Title
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Efficiency of the Quadratus Lumborum Block for Post-operative Analgesia in Abdominoplasty Surgery

Conditions
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Abdominoplasty, Quadratus Lumborum Block, Analgesia, Locoregional Anesthesia

Intervention / Treatment
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* Other: QLB anesthesia
* Other: Intravenous anesthesia without QLB


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Adult patients admitted for programmed dermo-lipectomy surgery with or without associated liposuction. Exclusion Criteria: Pregnant woman Patient under 18 years of age Subject under guardianship or curators Patient allergic to local anesthetics Infection at the puncture sites Patient on morphine analgesic over the long term Patient on antidepressants for neuropathic pain.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: QLB technique<br> | Other: QLB anesthesia<br>* The QLB is a bilateral locoregional anesthesia technique, performed after surgery, under general anesthesia and in right and then left lateral decubitus.<br>|
| Active Comparator: Intravenous anesthesia without QLB<br> | Other: Intravenous anesthesia without QLB<br>* only intravenous anesthesia<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variation from baseline of morphine consumption |  | 24 hours after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Variation from baseline of morphine consumption |  | 1 hour after surgery | 
| Variation from baseline of morphine consumption |  | 2 hours after surgery | 
| Variation from baseline of morphine consumption |  | 48 hours after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Quadratus lumborum block, Abdominoplasty, Analgesia, Locoregional Anesthesia