Plant-based Diets and Risk of Cancer in the Adventist Health Study-2

Study Overview
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Brief Summary
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The Adventist Health Study-2 is a long-term study, exploring the links between lifestyle, diet, and disease outcomes among Seventh-day Adventists. More than 96,000 church members from the U.S. and Canada are participating in the current study, AHS-2, conducted by researchers at the Loma Linda University School of Public Health.

Detailed Description
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The Adventist Health Study-2 (AHS-2) is a large national cohort of 96,000 Seventh-day Adventists in the U.S. and Canada. The study is searching for associations between diet and risk of common and medium frequency cancers (breast, prostate, colorectal, lung, uterus, pancreas, melanoma of skin). This cohort is unusual in that about half are vegetarian, many eat soy at Asian levels, and many have very low or absent dairy intake while others eat normal amounts of dairy. Thus observations on these people, many of whom have contrasting dietary habits, may provide insights about diet and cancer, so supporting dietary changes that could be readily adopted by many.

Official Title
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Cancer Epidemiology in Seventh-day Adventists

Conditions
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Cancer, Breast, Cancer, Colorectal, Cancer, Prostate

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Member of a Seventh-day Adventist church >30 years of age Ability to read English Live in the US or Canada Exclusion Criteria: Less than 30 years of age Church members who did not complete the baseline questionnaire. Incarcerated or institutionalized people Non-English speakers

Ages Eligible for Study
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Minimum Age: 30 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Seventh-day Adventists<br>This is a prospective cohort study of 96,000 members of the Seventh-day Adventists Church in the United States and Canada age 30 and older at the time of enrollment who are proficient in English language. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incident cases of breast cancer among subjects with documented dietary habits. | Incident cases of breast cancer as found by linkage with state cancer registries will allow calculation of hazard ratios comparing extreme quintiles of dietary intakes. The focus is on meats, soy, and dairy intakes. | Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incident cases of prostate cancer among subjects with documented dietary intakes. | Incident cases of prostate cancer as found by linkage with state cancer registries will allow calculation of hazard ratios comparing extreme quintiles of dietary intakes. The focus is on meats, soy, and dairy intakes. | Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment. | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Seventh-day Adventists, vegetarian, mortality, cancer, dietary pattern, soy consumption, dairy consumption, plant-based