Alveolar Ridge Preservation Using Different Bone Substitutes

Study Overview
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Brief Summary
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The primary objective of this study was to compare the efficacy of using allograft, autogenous tooth graft, and beta-tricalcium phosphate for alveolar ridge preservation (ARP) by examining the alveolar ridge height and width at baseline and 3 months after the ARP both clinically and radiographically. The secondary objective was to evaluate the quality of the newly formed bone using histomorphometric analysis.

Detailed Description
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This randomized controlled clinical trial included thirty patients. ARP was performed using either Allograft (Allograft group n=10), Tooth graft (Toothgraft group n=10), and beta tri-calcium- phosphate (beta tri-calcium group n=10). Changes in alveolar ridge dimensions were evaluated clinically and radiographically using cone beam computed tomography at baseline and 3 months. Core bone biopsy samples were obtained 3 months post-extraction during implant placement for histomorphometric analysis.

Official Title
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The Effect of Allograft, Toothgraft, Alloplast on Alveolar Ridge Preservation

Conditions
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Alveolar Ridge Enlargement

Intervention / Treatment
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* Drug: Toothgraft
* Drug: Allograft
* Drug: Alloplast


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: seeking implant-based restorations after tooth extraction. exhibited no evidence of any significant medical history, measured using Burket's Oral medicine health history questionnaire. exhibited Type I and II sockets Exclusion Criteria: nonsmokers. Pregnant and breast-feeding females patients with known contraindications to dental implant surgery (e.g., increased bleeding tendency, history of treatments such as radiotherapy,

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 40 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Alveolar ridge preservationwith tooth graft<br>tooth graft | Drug: Toothgraft<br>* Particulate dentin<br>|
| Active Comparator: Alveolar ridge preservation with allograft<br>Allograft | Drug: Allograft<br>* Mineralized corticocancellous allograft<br>* Other names: Mineralized corticocancellous allograft;|
| Active Comparator: Alveolar ridge preservation with alloplast<br>Beta Tri-Calcium phosphate | Drug: Alloplast<br>* Beta tri-calcuim phosphate<br>* Other names: Beta tri-calcuim phosphate;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Clinical assessment | Measure bone height loss in millimeter at baseline and after 3 months was measured using periodontal probe from the stent margin to the alveolar ridge crest at six points. In addition, Bone width loss was calculated by measuring alveolar ridge width buccopalatally in millimeter using a caliper clamp. The measurement was done perpendicular to the tangent of the dental arch at the mid-point of the extraction site approximately 4mm apical to the level of the marginal gingiva of the adjacent teeth. | 3 months | 
| Clinical assessment | Bone width loss was calculated by measuring alveolar ridge width buccopalatally in millimeter using a caliper clamp. The measurement was done perpendicular to the tangent of the dental arch at the mid-point of the extraction site approximately 4mm apical to the level of the marginal gingiva of the adjacent teeth. | 3 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Radiographic assessment | Measuring loss in bone height in millimeters between baseline and after 3 months. Loss in bone height was calculated by measuring the distance from the alveolar crest both buccally and palatally to a fixed anatomical landmark. In addition, | 3 months | 
| Radiographic assessment | Loss in bone width was calculated by measuring distance from buccal alveolar crest to palatal alveolar crest in millimeter. | 3 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Alveolar ridge preservation, Allograft, Toothgraft, Allopast