Study of Factors Influencing Post-stroke Dementia

Study Overview
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Brief Summary
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If the risk of dementia occurrence after stroke is well known, few data exist about the factors influencing positively or negatively the developement of cognitive disorders or dementia. The aim of the study is so to determine prospectively the clinical, biological, lesional and pharmacological factors associated with post-stroke dementia by the long-term follow-up of a stroke patient cohort.

Detailed Description
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The STROKDEM study is based on the 5-year prospective follow-up of a population of 1100 stroke patients without dementia. At inclusion in the cohort, main antecedents and risk factors, previous treatment and lifestyle, initial severity and etiology are recorded. Biological samples (for standard ans specialized analyses) and MRI are performed at 72h after stroke occurrence. Thereafter, patients are regularly (6 months, 12 months, 36 months, 60 months) examined for clinical and cognitive assessment with biological samples and Magnetic Resonance Imaging. Patients with dementia will be compared to patients without stroke to identify, by logistic regression analysis and Cox model, the factors associated with dementia occurrence.

Official Title
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Characterization of Clinical, Biological, Morphological and Pharmacological Factors Influencing Occurrence of Dementia or Cognitive Disorders After Stroke

Conditions
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Cerebrovascular Disorders, Dementia

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients > 40 years olds hemispheric stroke stroke dating from less 72h IQ-code < 64 patient (or his family) given an informed consent Exclusion Criteria: non hemispheric stroke malformative intracranial hemorrhage traumatic intracranial hemorrhage subarachnoidal hemorrhage contra-indication to MRI patients unable to answer to cognitive battery

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 95 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cohort of stroke patients<br>patients, over 40 years old and without dementia, displaying an hemorrhagic or an ischemic stroke, with a sus-tentorial localization, and included 72h before the onset of symptoms | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dementia occurrence | This evaluation will be based on a neurological and general clinical examination, and on the evaluation of activities of daily life using the Instrumental Activities Daily Life scale after an interview with the patient and his/her family. | 60 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| dementia occurrence and cognitive impairment | This evaluation will be based on a neurological and general clinical examination, and on the evaluation of activities of daily life using the Instrumental Activities Daily Life scale after an interview with the patient and his/her family. Impairment of some tests of cognitive battery without significant impairment in activities of daily living | 6 months | 
| dementia occurrence and cognitive impairment | This evaluation will be based on a neurological and general clinical examination, and on the evaluation of activities of daily life using the Instrumental Activities Daily Life scale after an interview with the patient ans his/her family. Impairment of some tests of cognitive battery without significant impairment in activities of daily living | 12 months | 
| dementia occurence and cognitive impairment | This evaluation will be based on a neurological and general clinical examination, and on the evaluation of activities of daily life using the Instrumental Activities Daily Life scale after an interview with the patient ans his/her family. Impairment of some tests of cognitive battery without significant impairment in activities of daily living | 36 months | 
| cognitive impairment | Impairment of some tests of cognitive battery without significant impairment in activities of daily living | 36 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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stroke, Brain ischemia, Intracranial hemorrhage, Dementia, Vascular, Alzheimer's disease