Fat-Associated Cardiovascular Organ Dysfunction

Study Overview
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Brief Summary
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This is an observational study of cardiovascular risk factors and arterial or cardiac function in subjects with overweight or obesity. Subjects must be between 30 and 65 years of age, have a body mass index >27.0 kg/m2 and free from known heart disease and digestive or psychiatric disorders. Study aims include identifying sex-differences in traditional cardiovascular risk factors and structural and functional abnormalities in arteries and the heart in subjects with overweight or obesity, and how this is influenced by physical fitness.

Detailed Description
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FATCOR is an observational study of women and men with overweight or obesity. In particular prevalences of conventional cardiovascular risk factors and subclinical arterial or cardiac dysfunction are explored. The study aims at identifying sex differences in presence and clustering of cardiovascular risk factors and presence of subclinical cardiovascular organ damage. The influence of physical fitness on these factors will also be assessed. All participants undergo extensive cardiovascular risk factor assessment including oral glucose tolerance test and ambulatory blood pressure recording. Subclinical cardiovascular dysfunction is assessed by carotid and femoral vascular ultrasound, echocardiography and carotid-femoral pulse wave velocity using applanation tonometry. Physical fitness is assessed from peak oxygen uptake during maximal exercise testing on a treadmill.

Official Title
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Fat-Associated Cardiovascular Organ Dysfunction

Conditions
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Overweight, Obesity

Intervention / Treatment
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* Other: There is no intervention


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: body mass index > 27.0 kg/m2 Exclusion Criteria: known heart disease digestive disorder psychiatric disorder unfamiliar with Norwegian language

Ages Eligible for Study
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Minimum Age: 30 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Intervention/Treatment |
| --- |
|Other: There is no intervention|This is a prospective observational cohort study without any intervention|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Abnormal left ventricular geometry | Echocardiography | At study baseline | 
| Dilated left atrium | Echocardiography | At study baseline | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Relation of physical fitness to prevalence of cardiovascular risk factors | Cardiopulmonary exercise | At study baseline | 
| Relation of sex to prevalence of hypertension | Ambulatory blood pressure recording | At study baseline | 
| Relation of sex to abnormal left ventricular geometry | Echocardiography | At study baseline | 
| Relation of sex to arterial stiffness | Applanation tonometry | At study baseline |