The Standard Management of HPV Infection

Study Overview
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Brief Summary
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High-risk human papillomavirus (HR-HPV) infection is a necessary condition in the occurence and development of cervical squamous intraepithelial lesion (SIL) and cervical cancer. There are cases that high-grade SIL (HSIL) and stage IA1 cervical squamous cancer remain or reoccur, or even become more severe after conization. The infection situation of HR-HPV, which plays an important role in the prognosis of cervical lesion, should be consulted in the management and follw-up after conization. It is worthwhile making further study in the specific practical significance of the HR-HPV in the prognosis of cervical lesion, as well as the high-risk factors that influence the prognosis of HR-HPV.

Detailed Description
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Main purpose:To work out the standard management of HPV infection by following up the HPV infection situation of the patients with high-grade SIL (HSIL) and stage IA1 cervical squamous cancer after conization. Research design:First, to do the retrospective analysis toward the patients who received conization between Jan 2009 to Aug 2016.Second,to do the prospective analysis toward the patients who received conization between Spt 2016 to Aug 2018. Inclusive criteria of study population:The patients who had finished HPV genotype testing before conization;who had never received treatment other than conization;who were histologically diagnosed as HSIL or IA1 cervical squamous cancer;who had not been diagnosed as any cervical diseases before;who were under age 70;who did not have any severe diseases that influence the follow-up. Follow-up methods:to do the follow-up to the target patients by 3,6,9,12,18,24 months after conization. Follow-up contents:the HR-HPV genotype infection before conization;the grade of lesion;the age when received conization;the gravity and parity;the situation of the glands invovement

Official Title
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The Standard Mangagement of High-Risk HPV Infection During Follow-up Visits

Conditions
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the High-Risk HPV Infection

Intervention / Treatment
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* Diagnostic Test: HPV genotype test


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: age not above 70 histologically diagnosed as HSIL or stage IA1 cervical squamous cancer received conization in Beijing Obstetrics and Gynecology Hospital HR-HPV infected without any treatment other than conization HR-HPV genotype tested before coniztion Exclusion Criteria: age above 70 with severe desease that influence the follow-up received other treatment on cervical lesion data incompleted not meet the inclusive criteria

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| HSIL<br>the patients with HSIL | Diagnostic Test: HPV genotype test<br>* HPV genotype test is a diagnostic test by smearing the cervix to find out whether a patient is hpv infected, and if infected, the test can descover the concrete hpv genotype.<br>|
| stage IA1 cervical squamous cancer<br>the patients with stage IA1 cervical squamous cancer | Diagnostic Test: HPV genotype test<br>* HPV genotype test is a diagnostic test by smearing the cervix to find out whether a patient is hpv infected, and if infected, the test can descover the concrete hpv genotype.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| The HR-HPV clearance | The difference of the HR-HPV clearance between HSIL and stage IA1 cervical squamous cancer | 24 months |