Lung Ultrasound for Assessment of Patients With Moderate to Severe Covid-19

Study Overview
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Brief Summary
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This observational study will describe lung ultrasound (LUS) findings over time in hospitalized patients with moderate to severe Covid-19 lung disease. Our primary aim is to investigate if lung ultrasound can identify and/or predict patients requiring mechanical ventilation. Another aim is to describe LUS findings associated with clinical findings and patient condition.

Detailed Description
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Study patients with moderate to severe Covid-19 infection will be screened with lung ultrasound daily. Lung ultrasound will be assessed by LUS-score for acute respiratory distress syndrome (ARDS) (0-36 points, Bouhemad 2015). Findings of B-line artifacts and consolidations will be noted. In addition to LUS, clinical parameters from physical examination and laboratory tests will be collected. Participants wil be followed until either admission to intensive care unit (ICU) for mechanical ventilation or until clinical improvement. A group of patients with mild Covid-19 infection will be recruited and screened once as reference. Apart from assessment with LUS, patients are managed according to routine care.

Official Title
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Lung Ultrasound for Assessment of Patients With Moderate to Severe Covid-19

Conditions
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Corona Virus Infection, Virus Diseases, Coronaviridae Infections

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Covid-19 confirmed by positive polymerase chain reaction (PCR) oxygen by mask or nasal prongs ≥ 4 l/min or high flow nasal cannula (HFNC) with fraction of inspired oxygen (FiO2) ≥ 30% age between 18-80 years informed consent Exclusion Criteria: patients subject to treatment-limitation no ICU history of heart failure history of lung disease e.g.: pneumonectomy, pulmonary fibrosis or other interstitial lung disease, pleurodesis history of kidney failure requiring dialysis any reason making lung ultrasound or daily follow up impossible opposition to participation in the study

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Identification of requirement of mechanical ventilation | Assessment of LUS-score or findings of consolidations correlated to requirement of mechanical ventilation on ICU | 3 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Prediction of requirement of mechanical ventilation | Assessment if LUS-score or findings of consolidations is able to anticipate clinical deterioration with requirement of mechanical ventilation on ICU | 3 weeks | 
| Association of LUS to clinical parameters | Descriptive assessment of clinical parameters and LUS-score over time | 3 weeks | 
| Description of findings on LUS | Description of quality and distribution pattern of LUS-findings in patients with different severities of Covid-19 | 3 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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ultrasonography, lung ultrasound, covid-19, ARDS