New Echocardiographic Parameters for Prediction of Response to Cardiac Resynchronization Therapy

Study Overview
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Brief Summary
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Echocardiography parameters for cardiac dyssynchrony had no predictive value in current multicentric prospective studies concerning cardiac resynchronization therapy. Comprehensive echocardiography and new parameters as 2D and 3D strain, as well as 3D echo have been analyzed, but their definite value has not been proven yet.

Detailed Description
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In patients with severe heart failure, delays in the conduction system can result in asynchronous contraction impairing cardiac function. By implantation of pacemaker systems with three leads located in atrium, right ventricle and coronary sinus, tracing back this deranged contraction closer to the physiological excitation propagation is aimed (cardial resynchronization therapy [CRT]). Despite patient selection according to the guidelines nearly one-third of the patients do not profit, neither clinically nor echocardiographically, from an implanted CRT-device. In addition, recent studies have shown that no reliable prediction may be achieved with the known echocardiographic parameters of dyssynchrony, regarding the response to such therapy. The aim of this study is therefore to assess new echocardiographic parameters, which may allow to better predict CRT response.

Official Title
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New Approaches to Echocardiography Assessment of Cardiac Dyssynchrony: Relevance Concerning Response Rate to Cardiac Resynchronization Therapy

Conditions
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Congestive Heart Failure

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: congestive heart failure, dilated cardiomyopathy, indication for implantation of a CRT-device according to the European Society of Cardiology (ESC) Exclusion Criteria: persons who are incapable of giving informed consent acute heart attack arrhythmia during the examination (such as atrial fibrillation and frequent VES) state after STEMI with an extended scar inotropic drug therapy pre-existing permanent pacemaker stimulation

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| 3D echocardiography | offline analysis of echocardiography data | 12 months | 
| 2D strain | offline analysis of echocardiography data | 12 months | 
| m-mode echocardiography | offline analysis of echocardiography data | 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| NYHA | New York Heart Association (NYHA) functional classification | 12 months | 
| six-min walk test | distance walked over 6 minutes as a sub-maximal test of aerobic capacity | 12 months | 
| NT-proBNP | N-terminal prohormone of brain natriuretic peptide (NT-proBNP) | 12 months | 
| LV EF | left ventricular (LV) ejection fraction (EF) | 12 month |