Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Study Overview
=================
Brief Summary
-----------------
The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Official Title
-----------------
Corticostriatal Neurophysiology in Parkinson's Disease Cognitive Impairment

Conditions
-----------------
Parkinson Disease

Intervention / Treatment
-----------------
* Other: Neurophysiology recordings
* Procedure: Neural stimulation


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion criteria: Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center Planned clinical electrode trajectory that contacts caudate Age greater than or equal to 40 Diagnosis of Parkinson's disease Able to participate in intraoperative testing English speaking Exclusion criteria: Age less than 40 Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions) Movement disorder other than Parkinson's disease

Ages Eligible for Study
-----------------
Minimum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Neural recordings and stimulation<br> | Other: Neurophysiology recordings<br>* Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a working memory task evaluated<br>Procedure: Neural stimulation<br>* Neural stimulation will be delivered during a working memory task and its impact on task performance quantified<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Changes in caudate DLPFC beta coherence | Caudate DLPFC coherence will be computed at rest and during the working memory task and correlated with cognitive metrics | Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours | 
| Changes in working memory performance with neural stimulatoin | The working memory task will involve seeing a series of words presented on the screen and pressing a button to respond. Working memory task performance will be compared between stimulated and non stimulated blocks and between stimulation targets | Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in beta power with neural stimulation | Beta power will be computed and compared between stimulation on and off conditions for different targets | Baseline to end of deep brain stimulation (DBS) surgery, approximately 3-4 hours | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Deep Brain Stimulation