Proteiomic Fingerprints of Gastric Juice

Study Overview
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Brief Summary
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No accurate, inexpensive and non-invasive test for gastric cancer screening is currently available. The investigators' recent study identified a1-antitrypsin and other proteins as potential biomarkers of gastric cancer in gastric juice. The aim of this study was to develop a novel non-invasive modality for detecting gastric cancer by measurement of biomarkers in gastric juice.

Detailed Description
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Patients and methods: The study consisted of two parts: (1) investigating the differences in gastric juice biomarker concentrations between gastric cancer patients and controls, and (2) screening gastric cancer using string test to obtain gastric juice followed by immunoassay for biomarker concentration.

Official Title
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Diagnosis of Gastroduodenal Diseases by Proteiomic Fingerprints of Gastric Juice

Conditions
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Gastric Cancer

Intervention / Treatment
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* Other: normal subject
* Other: gastric cancer


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy subjects and gastric cancer patients documented by endoscopy. Exclusion Criteria: the use of proton pump inhibitors or histamine-2 receptor antagonists within 4 weeks prior to the study coexistence of two kinds of gastroduodenal lesions coexistence of severe systemic diseases

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: gastric cancer<br>gastric cancer patients | Other: normal subject<br>* biomarker in gastric juice, i.e., alpha 1-antitrypsin, CEA<br>* Other names: biomarker in gastric juice;Other: gastric cancer<br>* biomarker in gastric juice, e.g., alpha 1-antitrypsin<br>* Other names: biomarker in gastric juice;|
| Active Comparator: normal subject<br>healthy subject | Other: normal subject<br>* biomarker in gastric juice, i.e., alpha 1-antitrypsin, CEA<br>* Other names: biomarker in gastric juice;Other: gastric cancer<br>* biomarker in gastric juice, e.g., alpha 1-antitrypsin<br>* Other names: biomarker in gastric juice;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Number of Participants With Accurate Diagnosis for Gastric Cancer | Normal subject group: number of the subjects with normal alpha 1-antitrypsin level in gastric juice Gastric cancer group: number of the subjects with elevated alpha 1-antitrypsin level in gastric juice | 2 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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gastric cancer, proteomics, gastric juice