Effects of Ten-Weeks Progressive Resistance Training on Neuromuscular Performance, Mobility, Heart Rate Variability and Sleep Quality in Persons With Multiple Sclerosis

Study Overview
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Brief Summary
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Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Strength training has been shown to improve strength and mobility in persons with MS.

Detailed Description
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Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Resistance training has been shown to improve strength, sleep quality and mobility in persons with MS.

Official Title
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Effects of Ten-Weeks Progressive Resistance Training on Neuromuscular Performance, Mobility, Heart Rate Variability and Sleep Quality in Persons With Multiple Sclerosis

Conditions
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Multiple Sclerosis

Intervention / Treatment
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* Other: Physical exercise
* Other: Testing sessions


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: mild or moderate disability with clinical mild spastic-ataxic gait disorder. stable phase of the disease. Exclusion Criteria: Expanded Disability Status Scale (EDSS) < 6. relapsing disease within the preceding 12 months. corticosteroid treatment within the last months before study inclusion.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Control group<br>Only testing sessions | Other: Testing sessions<br>* Testing sessions<br>|
| Experimental: Progressive resistance training group<br>10-weeks of progressive resistance training group. Leg press, leg extension, calf raises, hip extension exercises. | Other: Physical exercise<br>* Physical exercise intervention<br>Other: Testing sessions<br>* Testing sessions<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Maximal Voluntary Isometric Contraction of Knee Extension | the maximum force (N) that can be produced voluntarily by the knee extension muscles during an isometric contraction is measured. The leg of the participant is fixed to an isokinetic device, and the participant makes a 5-second attempt, developing all the strength he or she can. | Before the program training | 
| Maximal Voluntary Isometric Contraction of Knee Extension | the maximum force (N) that can be produced voluntarily by the knee extension muscles during an isometric contraction is measured. The leg of the participant is fixed to an isokinetic device, and the participant makes a 5-second attempt, developing all the strength he or she can. | After 10 weeks | 
| Rate of Force Development | Rate of force development in knee extension | Before the program training | 
| Rate of Force Development | Rate of force development in knee extension | After 10 weeks | 
| Central Activation Ratio | The central activation ratio (CAR) was determined using superimposed electrical stimulation during maximum voluntary contractions | Before the program training | 
| Central Activation Ratio | The central activation ratio (CAR) was determined using superimposed electrical stimulation during maximum voluntary contractions | After 10 weeks | 
| Spasticity | Pendulum test | Before the program training | 
| Spasticity | Pendulum test | After 10 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Walking speed | Test 10 m-walks | Before the program training | 
| Walking speed | Test 10 m-walks | After 10 weeks | 
| Static Balance | Romberg Test with eyes open and closed. Analysis with force plates | Before the program training | 
| Static Balance | Romberg Test with eyes open and closed. Analysis with force plates | After 10 weeks | 
| Functional capacity | Sit-to-Stand Test | Before the program training | 
| Functional capacity | Sit-to-Stand Test | After 10 weeks | 
| Heart Rate Variability | Sleeping Heart Rate Variability | Before the program training | 
| Heart Rate Variability | Sleeping Heart Rate Variability | After 10 weeks | 
| Sleep Quality | Acelerometry and Karolinska Sleep Diary | Before the program training | 
| Sleep Quality | Acelerometry and Karolinska Sleep Diary | After 10 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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neurological disorders, resistance training, strength training, sleep quality, neuromuscular performance, functional capacity