In Vivo Study of Sucrose and Liquid Oral Pediatric Medicines of Long-term Effect on Dental Biofilm pH

Study Overview
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Brief Summary
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The aims of this study were to determine the sucrose and liquid oral pediatric medicines of long-term effect on dental biofilm pH to evaluate the cariogenic potential in vivo.

Detailed Description
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Te study was carried out with 12 subjects that were refrained from brushing their teeth for 28 h and did not eat or drink for at least 3 h prior to each appointment. Dental biofilm pH was measured in the cervical and proximal regions of anterior teeth with beetrode-type microelectrode coupled to a potentiometer. The biofilm was submitted nine paediatric medicines a long term and sucrose (negative control). pH measurements were taken at baseline to determine resting plaque pH and at time interval 5, 10, 15, 20, 25 and 30 minutes.

Official Title
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Avaliação in Vivo do Potencial cariogênico e Erosivo de Bebidas e Medicamentos pediátricos líquidos Intra-orais

Conditions
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Dental Biofilm pH

Intervention / Treatment
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* Other: G1, G2 and G3
* Other: G4 and G5


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age 18 to 22 years; Having Oral hygiene adequate (OHI<1.1); Having 20 natural teeth incluing molar; Not havind oral disease. Exclusion Criteria: Biofilm baseline pH > 5,5; Not signature consent term; Using orthodontic appliance; Having used medicines last 3 months; Pregant woman.

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 22 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Triple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: G4 and G5<br>Application of antibiotic group of pediatric medicines and control group (sucrose 10 %)on dental biofilm. | Other: G4 and G5<br>* Application of trhree pediadic medidines of antibiotic group on dental biofilm 12 subjects<br>|
| Experimental: G1, G2 and G3<br>Application of Nutritional, Respiratory and Endocrine groups medicines pediatric on dental biofilm | Other: G1, G2 and G3<br>* Nutritional, respiratory and endocrine group applicated 12 subjects<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of group respiratory, nutritional and endocrine pediatric medicines effect on dental biofilm pH | pH was measured in the cervical and proximal regions of anterior teeth dental biofilm with beetrode-type microelectrode coupled to a potentiometer | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Evaluation of sucrose antibiotic group and control negative group effect on dental biofilm | The biofilm was submitted antibiotic group and negative control group. pH measurements were taken at baseline to determine resting plaque pH and at time interval 5, 10, 15, 20, 25 and 30 minutes. | 12 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Dental caries, Sucrose, Oral administration, Ion Concentration of Hydrogen, Pediatric medicines