China Action on Spine and Hip Status

Study Overview
=================
Brief Summary
-----------------
To determine the prevalences of osteoporotic fracture in elderly Chinese population. To determine the prevalences of osteoporosis in elderly Chinese population using QCT BMD measurement. To investigate the difference in the prevalences of osteoporosis between cities and urban-rural area in China. To investigate the association of body composition with osteoporosis To investigate the prevalence of liver steatosis in China To investigate the application of QCT fat measurement

Detailed Description
-----------------
Osteoporosis and osteoarthritis (OA) both are very common in elderly population,it is particular important for China with a huge aging population in the coming years.Bone mineral density measured by quantitative computed tomography (QCT) or dual energy X-ray absorptiometry (DXA) is the surrogate for bone health status and diagnosis of osteoporosis and OA. In this study we utilize the large-scale population based epidemiology study (PURE) population,spine and hip QCT and/or DXA will be obtained for the subject to investigate the prevalence of osteoporosis and osteoarthritis in elderly Chinese population. We also study the relation between bone mineral density with osteoporotic fracture and OA More than 3000 subjects selected from the PURE study participants in Beijing and other centers in China will be recruited to this study. More precisely, the subjects are consisted of the females over 55 years and males over 60 years old, along with the 20% randomly selected PURE participants for blood sampling. Beijing ji shui tan hospital will be the coordinate center for the whole study, Beijing shi jing shan hospital, Beijing shun yi traditional medicine hospital and Taiyuan central hospital of shanxi will participate, other centers may be added late. Bone mineral density of spine and hip will be measured with QCT and/or DXA. Quantitative computed tomography QCT pro (Mindways software, inc. USA) will be used for all QCT measurement, the CT scanner will be the clinical CT scanner of the local participated center. Quality control and monitoring will be conducted by Beijing ji shui tan hospital, as well as the centralised image interpretation. Therefore, this study is designed to provide the current and reliable prevalence of osteoporotic fracture, osteoporosis, OA in elderly Chinese population using QCT and/or DXA. The performance of QCT and DXA in the diagnosis of osteoporosis , as well as the association of body composition with osteoporosis will be assessed.

Official Title
-----------------
Multi Center Survey on Spine and Hip Status in Chinese Population Using Quantitative Computed Tomography (QCT)

Conditions
-----------------
Osteoporosis, Liver Steatosis, Metabolic Syndrome, Obesity

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Participants of the PURE study in China (PURE China study) be willing to and be able to join in the study and signed Informed consent Exclusion Criteria: Pregnant Spine and both hip implants

Ages Eligible for Study
-----------------
Minimum Age: 29 Years
Maximum Age: 90 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------
What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Osteoporotic fractures | The spine osteoporotic fractures assessed on the lateral spine image of QCT exam | 5 years | 
| Bone mineral density (BMD) of spine and hip | BMD measurement at the spine by QCT and hip | 5 years | 
| liver steatosis | The liver steatosis assessed by QCT | 5 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Metabolic syndrome | Diagnosis of metabolic syndrome and visceral fat | 5 years | 
| visceral fat measurement by QCT | visceral fat measurement and distribution assessed by QCT at the abdomen and hip | 5 years | 
| Osteoarthritis of spine and hip | OA assessment at spine and hip by CT images | 5 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
bone mineral density, computed xray tomography, liver steatosis, obesity, osteoporosis, osteoarthritis