Effect of Preoperative Chemoradiotherapy on Exercise Capacity as Measured by Cardiopulmonary Exercise Testing

Study Overview
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Brief Summary
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This study will investigate the effect of preoperative chemoradiotherapy on exercise capacity as measured by cardiopulmonary exercise testing in patients with colorectal cancer.

Detailed Description
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Chemoradiotherapy is associated with adverse effects. Patients with certain colorectal cancers undergo chemoradiotherapy prior to surgical resection. We intend to assess patient exercise capacity before and after chemoradiotherapy to assess whether this deteriorates. If there is a deleterious effect, this may affect operative outcome.

Official Title
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Effect of Preoperative Chemoradiotherapy on Exercise Capacity as Measured by Cardiopulmonary Exercise Testing

Conditions
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Colorectal Cancer

Intervention / Treatment
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* Other: Cardiopulmonary exercise testing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age greater than 65 Colorectal cancer requiring preoperative chemoradiotherapy Exclusion Criteria: Inability to walk, or exercise on a bicycle or treadmill Inability to understand instructions for CPET testing ASA grade 4 or 5 (indicating severe cardiovascular co-morbidity and not expected to survive surgery) Contraindications to Exercise Testing Myocardial infarction occurring 10 days or less before CPX testing Symptomatic arrythmias Left Main Stem coronary disease of >50% Severe hypertension (SBP>180mmHg) Resting SpO2 <85% Acute cardiac inflammatory conditions (myocarditis, pericarditis) Unstable angina with symptoms within 4 days Dissecting aneurysm of aorta Acute pyrexial illness Thyrotoxicosis Syncopal episodes Lower limb thrombosis (arterial or venous)

Ages Eligible for Study
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Minimum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Test arm<br>Patients undergoing preoperative chemoradiotherapy will have their exercise capacity measured before and after chemoradiotherapy. | Other: Cardiopulmonary exercise testing<br>* Cardiopulmonary exercise testing involves cycling on an exercise bicycle whilst oxygen consumption and carbon dioxide generation are measured from expired gases. This is used to calculate patient fitness from their peak oxygen consumption and their anaerobic threshold.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change of Anaerobic threshold of 1.5ml/min/kg or more |  | 6 weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Operative outcome |  | 6-10 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Exercise capacity, Chemoradiotherapy, Colorectal cancer