French National Observatory on Infective Endocarditis

Study Overview
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Brief Summary
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The objective of this observatory is to provide a national database of infective endocarditis, informed by all volunteer centers, using a standardized case report forms. Such an observatory will describe the clinical profile, microbiological, therapeutic and evolving of infective endocarditis (IE); analyze the risk factors for the disease and its prognosis factors of evolution; describe management practices; evaluate and compare in the real drug treatment strategies (including antibiotics) and surgical.

Detailed Description
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All the clinical, biological, microbiological and laboratory describing the history of patients and their evolution during hospitalization for infective endocarditis will be obtained from physicians supporting patients and recorded in an electronic case report form. Will include collected clinical characteristics (site, pre-existing heart disease underlying symptoms, complications), biological characteristics (dosage on admission and diagnosis), microbiological characteristics (identifying the genus and species of the microorganism responsible, sensitivity to antibiotics susceptibility testing and evaluated by determination of minimal inhibiting concentration (MIC), exhaustive search of the rare forms of endocarditis uncultivated microorganisms), an analysis of the gateways based on the causative organism; echocardiographic characteristics (number and size of vegetations, valvular damage, scalable: surgery, lethality) and therapeutic characteristics (antibiotic treatment, surgical).

Official Title
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French National Observatory on Infective Endocarditis

Conditions
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Infective Endocarditis

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Major Patient Supported in one of the participating centers The application of diagnostic classification criteria of Duke modified by Li is carried out after collection of all the data at the end of the patient's hospitalization. Only patients meeting criteria for definite or possible endocarditis will be included in the analyses. Registered with the French social security system Exclusion Criteria: • Refusal of the patient to participate.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| history of heart disease | status of heart valves, pre-existing heart conditions | inclusion | 
| risk factors, medical history | associated diseases | inclusion | 
| origin of infection | high risk procedures | period of 3 months before infective endocarditis | 
| weight | kg | inclusion | 
| height | cm | inclusion | 
| clinical symptoms | cardiac, peripheral and neurological symptoms | inclusion | 
| biological outcomes | blood count | inclusion | 
| microbiological outcomes | identification of infecting organisms | inclusion | 
| diagnostic imaging | description of tyhe imaging tests performed | inclusion | 
| antibiotic therapy | antibiotic treatment: type and duration | from inclusion to recovery | 
| surgical procedures | description of surgical procedures | from inclusion to recovery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| biologic collection (optional) | plasma and serum collection | inclusion |