The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old

Study Overview
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Brief Summary
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The main purpose of this study is to investigate the effects of partial sleep deprivation (PSD) on resting state brain connectivity, emotional contagion, empathy, and emotional regulation.

Official Title
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The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old

Conditions
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Sleep Deprivation

Intervention / Treatment
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* Behavioral: Partial sleep deprivation allowing 3 h sleep at night
* Behavioral: Full sleep


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 20-30 years of age, inclusive OR 65-75 years of age, inclusive Able to understand spoken and written Swedish (in order to understand instructions) Normal or corrected-to-normal vision not using glasses Not colour blind Right-handed Free from ferromagnetic objects in body No history of any neurologic or psychiatric illness including drug abuse No history of diabetes nor hypertension No depression according to ratings using the Hospital Anxiety and Depression scale (HAD) No insomnia according to ratings using the Insomnia Severity Index (ISI) and Karolinska Sleep Questionnaire (KSQ) No use of psychotropic drugs Not studying or working in medicine, psychology, nor behavioural science Not suffering from severe seasonal allergy No use of cortisone, anti-histamines, nor any other immune-modulating drugs Habitual intake of no more than 4 cups of coffee per day or the equivalent in terms of caffeine No daily use of nicotine Exclusion Criteria: -

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Sleep deprivation<br>Partial sleep deprivation allowing 3 h sleep at night | Behavioral: Partial sleep deprivation allowing 3 h sleep at night<br>* Participants sleep at home while monitored with ambulatory polysomnography. For the full sleep condition, they are instructed to go to bed and to get up at the usual times that they would normally do that. For the sleep deprivation condition, they are instructed to go to bed 3 hours before the time when they would usually get up, and then to get up at that time.<br>* Other names: Sleep loss;|
| Experimental: Full sleep<br>Sleep with no restriction | Behavioral: Full sleep<br>* Participants sleep at home while monitored with ambulatory polysomnography. For the full sleep condition, they are instructed to go to bed and to get up at the usual times that they would normally do that. For the sleep deprivation condition, they are instructed to go to bed 3 hours before the time when they would usually get up, and then to get up at that time.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Blood oxygen level-dependent response in amygdala to angry faces (t/z-score from statistical parametric mapping) | This registration is made in order to pre-specify hypotheses in a basic science project. For a full list of outcomes and hypotheses, see study description (above). | Change between 1st and 2nd MRI scanning session (approx. 1 month later) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sleep, resting state, functional connectivity, emotional contagion, empathy, emotional regulation