The Effect of Soluble Fiber Dextrin on Subjective and Physiological Markers of Appetite

Study Overview
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Brief Summary
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This study examines the effect of soluble fiber dextrin on food intake, appetite, and physiological markers of appetite. Adults aged 18-45 years with a BMI were recruited for this study. Participants were given two doses of SFD in the morning and appetite, food intake and physiological markers of appetite were measured over 10 years.

Detailed Description
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Overweight and obesity are leading health problems. The study investigates the effect of a food ingredient from two different sources at two different doses on food intake and appetite markers over a 10 hour period. All participants reported to the laboratory first thing in the morning and remained in the laboratory until after their evening meal. A fixed breakfast was served but the participants were free to eat as much as they liked at lunch and dinner. Blood was taken at regular intervals during the day and assayed for glucose and several hormones related to appetite. Subjective measures of appetite were also collected over the 10 hour test session.

Official Title
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The Effect of Soluble Fiber Dextrin on Subjective and Physiological Markers of Appetite: a Randomized Trial

Conditions
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Appetitive Behavior

Intervention / Treatment
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* Other: Soluble Fiber Dextrin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI 19.9 - 29.9 Aged 18-45 Find the study foods to be palatable Exclusion Criteria: Weight change > 3kg in the past three months Do not regularly consume snacks Presence or history of GI disorders Restrained eater Used medication that influences appetite

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 45 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Human subjects
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: SFD Tapioca 20g<br>20g soluble fiber dextrin derived from tapioca | Other: Soluble Fiber Dextrin<br>* Ingredient based on resistant starch<br>|
| Experimental: SFD Tapioca 40g<br>40g soluble fiber dextrin derived from tapioca | Other: Soluble Fiber Dextrin<br>* Ingredient based on resistant starch<br>|
| Experimental: SFD corn 20g<br>40g soluble fiber dextrin derived from corn | Other: Soluble Fiber Dextrin<br>* Ingredient based on resistant starch<br>|
| Experimental: SFD corn 40g<br> | Other: Soluble Fiber Dextrin<br>* Ingredient based on resistant starch<br>|
| Placebo Comparator: Control<br>Maltodextrin | Other: Soluble Fiber Dextrin<br>* Ingredient based on resistant starch<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Food intake | Food intake measured at lunch and evening meal. | 10 hours | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Appetite | Subjective appetite measures using questionnaires at regular intervals over 10 hours, | 10 hours | 
| CCK | Plasma CCK measured at regular intervals over 10 hours. | 10 hours | 
| GLP-1 | Plasma GLP-1 measured at regular intervals over 10 hours. | 10 hours | 
| PYY3-36 | Plasma PYY3-36 measured at regular intervals over 10 hours. | 10 hours | 
| Breath Hydrogen | Breath hydrogen measured at regular intervals over 10 hours. | 10 hours |