Study on the Antiaging Effect of Chinese Herb Drink

Study Overview
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Brief Summary
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The purpose of the current study was to check the physiological improvement of SWT on liver and skin and also the antioxidation in healthy adults.

Detailed Description
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Background: Si-Wu-Tang (SWT) is a well-known traditional Chinese medicine (TCM) and widely used for treating various gynecological disorders. The purpose of the current study was to check the physiological improvement of SWT on liver and skin and also the antioxidation in healthy adults. Methods: Sixty healthy voluntary subjects were recruited and assigned into two groups, who drank 125 mL of placebo (n=30) or SWT (n=30) for 6 continuous days per month during the following 6 months and vice versa with one month of washout period in between. During the initial, 3rd, 6th, 10th, and 13th months anthropometric measurements were performed as well as fasting blood samples were drawn for various biochemical assays. Abdominal ultrasonic and skin examination were performed at the initial, 6th and 13th months.

Official Title
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Study on the Antiaging Effect of Chinese Herb Drink

Conditions
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Gynecological Disorders

Intervention / Treatment
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* Other: Si-Wu-Tang (SWT)
* Other: placebo


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: healthy adults Exclusion Criteria: exclusion criteria were history of smoking, alcoholism pregnant or lactating women, chronic diseases, hepatic or renal dysfunction.

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Si-Wu-Tang (SWT)<br>Subjects are recommended to drink 125 mL of SWT (n=30) for 6 continuous days per month during the following 6 months and vice versa with one month of washout period in between. | Other: Si-Wu-Tang (SWT)<br>* The purpose of the current study was to check the physiological improvement of SWT on liver and skin and also the antioxidation in healthy adults.<br>* Other names: Si-Wu-Tang (SWT) is a Traditional Chinese Medicine formula;Other: placebo<br>* The purpose of the current study was to check the physiological improvement of placebo on liver and skin and also the antioxidation in healthy adults.<br>|
| Placebo Comparator: placebo<br>Subjects are recommended to drink 125 mL of Placebo (n=30) for 6 continuous days per month during the following 6 months and vice versa with one month of washout period in between. | Other: Si-Wu-Tang (SWT)<br>* The purpose of the current study was to check the physiological improvement of SWT on liver and skin and also the antioxidation in healthy adults.<br>* Other names: Si-Wu-Tang (SWT) is a Traditional Chinese Medicine formula;Other: placebo<br>* The purpose of the current study was to check the physiological improvement of placebo on liver and skin and also the antioxidation in healthy adults.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Total thiobarbituric acid reactive substances (TBARS) |  | 6 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glutathione content (GSH) |  | 6 months | 
| Total antioxidant capacity (TEAC)activities. |  | 6 months | 
| Superoxide dismutase (SOD) activity |  | 6 months | 
| GPx and glutathione reductase (GR) activity |  | 6 months | 
| Catalase |  | 6 months | 
| Glutamic oxaloacetic transaminase (GOT) |  | 6 months | 
| Glutamic pyruvic transaminase (GPT) |  | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Si Wu Tang, antioxidation, anthropometric measurements, liver, skin