Aizthromycin or Clarithromycin in H-pylori Eradication Regimen

Study Overview
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Brief Summary
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The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.

Detailed Description
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Eradication of helicobacter pylori is important for treatment of GU but ideal regimen is not available. HP is resistant to metronidazole and clarithromycin, thus clarithromycin is expensive and it is not available in underdevelopment countries. There are different articles about replacement clarithromycin with azithromycin as a method of eradication of HP that is decreases length of therapy and increases, effectiveness of drugs and decreases resistance of drugs. The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.

Official Title
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Comparison of Azithromycin or Clarithromycin in 3drugs Protocol of H-pylori Eradication Regimen

Conditions
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Peptic Ulcer, Dyspepsia, H-pylori

Intervention / Treatment
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* Drug: azithromycin
* Drug: clarithmycin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: patients with peptic ulcer due to H-pylori confirmed endoscopy and biopsy Exclusion Criteria: patients who got H-pylori eradication treatment previously patients who used study drugs during 3months before study

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: azithromycin<br>Azithromycin (Zithromax, Azithrocin ) is an azalide, a subclass of macrolide antibiotics. Azithromycin is one of the world's best-selling antibiotics. It is derived from erythromycin, with a methyl-substituted nitrogen atom incorporated into the lactone ring, thus making the lactone ring 15-membered. | Drug: azithromycin<br>* Azithromycin (Zithromax, Azithrocin ) is an azalide, a subclass of macrolide antibiotics. Azithromycin is one of the world's best-selling antibiotics.[1] It is derived from erythromycin, with a methyl-substituted nitrogen atom incorporated into the lactone ring, thus making the lactone ring 15-membered.<br>* Other names: (Zithromax, Azithrocin;|
| Experimental: clarithromycin<br>Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydophila pneumoniae), skin and skin structure infections. In addition, it is sometimes used to treat legionellosis, Helicobacter pylori, and lyme disease. | Drug: clarithmycin<br>* Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydophila pneumoniae), skin and skin structure infections. In addition, it is sometimes used to treat legionellosis, Helicobacter pylori, and lyme disease.<br>* Other names: Crixan, Claritt, Clarac, Biaxin, Klaricid, Klacid...;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| H-pylori cinfirmation | confirmation is by endoscopy and biopsy | 1-3 months before study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| h-pylori eradication confirmation | confirmation of eradication was by endoscopy and biopsy | two months after completion of 14 days standard treatment | 
| side effect of study srugs | it was assessed by researcher and self report of patients. variables like nausea, vomiting and diarrhea. the prevalence of each treatment related complain was registered by taking history from patients. | during 14 days standard treatment | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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H-pylori, eradication, azithromycin, clarithromycin