Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation

Study Overview
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Brief Summary
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The aim of the study is to investigate pulmonary hemodynamics at rest and during exercise in patients before and after kidney transplantation.

Official Title
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Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation

Conditions
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Pulmonary Hypertension, Kidney Transplantation, Haemodialysis

Intervention / Treatment
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* Diagnostic Test: exercise echocardiography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age: ≥ 18 years patients listed for first kidney transplantation at the Clinical Division of Nephrology Exclusion Criteria: Age < 18 years combined organ transplantations (heart-kidney, pancreas-kidney etc.) patients with prior kidney transplantation high calcium score on cardiac-CT (> 160 Agatston Score)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| kidney transplant candidates<br>Patients listed for first kidney transplantation | Diagnostic Test: exercise echocardiography<br>* All patients will undergo exercise echocardiography during a symptom-limited cardiopulmonary exercise test.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope | Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope (calculated as the difference of maximal and resting SPAP divided by the difference of maximal and resting CO) before versus one year after kidney transplantation assessed by exercise echocardiography | Baseline and 1 year after kidney transplantation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Change in systolic pulmonary arterial pressure at rest before versus one year after kidney transplantation assessed by (exercise) echocardiography |  | Baseline and 1 year after kidney transplantation | 
| Change in systolic pulmonary arterial pressure at 25 Watts before versus one year after kidney transplantation assessed by (exercise) echocardiography |  | Baseline and 1 year after kidney transplantation | 
| Change in mean pulmonary arterial pressure at rest before versus one year after kidney transplantation |  | Baseline and 1 year after kidney transplantation | 
| Change in mean pulmonary arterial pressure during exercise before versus one year after kidney transplantation |  | Baseline and 1 year after kidney transplantation | 
| Change in pulmonary vascular resistance at rest before versus one year after kidney transplantation |  | Baseline and 1 year after kidney transplantation | 
| Change in pulmonary vascular resistance during exercise before versus one year after kidney transplantation |  | Baseline and 1 year after kidney transplantation | 
| Change in pulmonary arterial wedge pressure at rest before versus one year after kidney transplantation |  | Baseline and 1 year after kidney transplantation | 
| Change in pulmonary arterial wedge pressure during exercise before versus one year after kidney transplantation |  | Baseline and 1 year after kidney transplantation | 
| Change in cardiac output at rest before versus one year after kidney transplantation |  | Baseline and 1 year after kidney transplantation | 
| Change in cardiac output during exercise before versus one year after kidney transplantation |  | Baseline and 1 year after kidney transplantation | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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pulmonary hypertension, kidney transplantation, vascular remodeling, echocardiography, pulmo-renal axis