Physical Exercise and Pollution: Cardiorrespiratory, Cerebral and Molecular Aspects

Study Overview
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Brief Summary
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Modern society increasingly seeks healthy life style, and regular physical activity is considered one of the main factors that improve the quality of life. The evidence shows that the aerobic physical training in controlled environments benefit various aspects of human health, including cognition in the elderly population. However, when exercise is performed in a polluted environment, the individual is subjected to grater exposure to pollutants due to increased ventilation (breathing).

Detailed Description
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Modern society increasingly seeks healthy life style, and regular physical activity is considered one of the main factors that improve the quality of life. The evidence shows that the aerobic physical training in controlled environments benefit various aspects of human health, including cognition in the elderly population. However, when exercise is performed in a polluted environment, the individual is subjected to grater exposure to pollutants due to increased ventilation (breathing). It is well known that inhaled pollutants can cause oxidative modification in biomolecules and oxidative stress is a cause of diverse diseases. This scenario raises important questions: the deleterious effects of pollution can abolish the beneficial effects of exercise? This issue is currently relevant given the increasing level of air pollution in large urban centers such as Sao Paulo city and at the same time, outdoor physical activity in public places is largely stimulated by public organizations, particularly for elderly. Thus this multidisciplinary project aims to investigate the deleterious effects of urban air pollution in elderly people who practice aerobic physical exercise outdoors in Sao Paulo and compare with those who practice in Laboratory. This study can provide important knowledge for public health and welfare of the population.

Official Title
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Physical Exercise and Pollution: Cardiorrespiratory, Cerebral and Molecular Aspects.

Conditions
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Cognitive Function 1, Social

Intervention / Treatment
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* Other: Physical Exercise


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Health Subjects that lives in São Paulo city for at least 10 years. - Exclusion Criteria: Neuropsychological issues. -
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Health Services Research
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Exercise and Pollution Groups<br>Physical Exercise performed in a clean environment and in a polluted environment. | Other: Physical Exercise<br>* Incremental running<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Cognitive Benefits | Neuropsychological Tests applied at the beginning and at the end of protocol | 12 weeks | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Physical Exercise, Atmospheric Pollution, Cognition.