Effect of Anesthesia on Quality of Recovery in Patients Undergoing Correctional Tibial Osteotomy - A Randomized Controlled Trial

Study Overview
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Brief Summary
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The effect of total intravenous anesthesia (TIVA) versus inhalational anesthesia on the quality of recovery from surgery has been reported in several different types of operations. The Quality of Recovery 40 (QoR-40) questionnaire is designed multi-dimensionally to assess the degree of recovery after anesthesia and surgery, and has been validated in previous studies. The present study aims to compare the quality of recovery with the QoR-40 questionnaire, in patients undergoing correctional tibial osteotomy under general anesthesia with either TIVA with propofol or inhalational anesthesia with desflurane.

Official Title
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Effect of Anesthesia on Quality of Recovery in Patients Undergoing Correctional Tibial Osteotomy - A Randomized Controlled Trial

Conditions
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Short Stature, Osteoarthritis

Intervention / Treatment
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* Drug: propofol and remifentanil
* Drug: desflurane and remifentanil


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 1. Adult patients over the age of 19 scheduled for cosmetic lower limg lengthening for short stature, or correctional tibial osteotomy for osteoarthritis Exclusion Criteria: Patient refusal Patients with altered mental status Ejection fraction under 55% Recent MI, CVA, or major cardiovascular surgery 3rd degree AV block, 2nd degree AV block with P:QRS ration greater than 3:1 Hemodynamically unstable patients requiring vasopressors or oxygen therapy Febrile patients Patients with decreased renal function (serum Cr > 0.1 mg/dL) Patients with known allergies to propofol Pregnant patients

Ages Eligible for Study
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Minimum Age: 19 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: TIVA group<br> | Drug: propofol and remifentanil<br>* Anesthesia is induced and maintained by effect-site target controlled infusion of propofol and remifentanil<br>|
| Active Comparator: Inhalation anesthesia group<br> | Drug: desflurane and remifentanil<br>* Anesthesia is induced and maintained with desflurane and remifentanil<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| QoR-40 score |  | 24 hours after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| QoR-40 score |  | preoperative period to 48 hours after surgery | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Total intravenous anesthesia, desflurane, QoR-40, correctional tibial osteotomy