Disconnection and Unilateral Spatial Neglect

Study Overview
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Brief Summary
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Retrospective cohort study of consecutive patients investigated in a neurorehabilitation ward after a first hemispheric stroke. Unilateral spatial Neglect (USN) and other cognitive impairments (including attention, executive functions, memory) have been assessed in routine care at the subacute phase (<6 months). MRI scans have also been done in routine care. The study aims at linking lesion characteristics, disconnections induced and expression of the different modalities of USN

Official Title
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Neural Basis of Unilateral Spatial Neglect After Stroke: a Retrospective Disconnectome Based Study

Conditions
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Stroke

Intervention / Treatment
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* Other: Cognitive assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: First hemispheric adult stroke patient Non-opposed to inclusion Confirmed by MRI Assessment of cognitive functions during the subacute phase (3 weeks to 6 months after stroke onset Exclusion Criteria: History of previous stroke or neurological disorders Inability to perform cognitive assessment due to severe comprehension, cognitive or psychiatric disorder Uncorrected severe loss of visual acuity Contra-indications to MRI

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Stroke patients<br>Stroke patients admitted to the Lille Neurological rehabilitation unit after a first-ever hemispheric stroke, assessed at the subacute phase (< 6months) | Other: Cognitive assessment<br>* Assessment of unilateral spatial neglect, attention, executive functions and memory<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment of peripersonal Unilateral Neglect with the BEN (Batterie d'évaluation de la negligence, Battery of tests for the quantitative assessment of unilateral neglect) |  | One assessment, during the subacute phase after stroke (3 weeks to 6 months) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assessment of personal Unilateral Spatial Neglect with the Fluff Test |  | One assessment, during the subacute phase after stroke (3 weeks to 6 months) | 
| Assessment of personal Unilateral Spatial Neglect with the Comb and Razor Test |  | One assessment, during the subacute phase after stroke (3 weeks to 6 months) | 
| Assessment of Attention with the Test of Attentional Performance |  | One assessment, during the subacute phase after stroke (3 weeks to 6 months) | 
| Assessment of Executive Functions with the Stroop Test |  | One assessment, during the subacute phase after stroke (3 weeks to 6 months) | 
| Assessment of Executive Functions with the Trail Making Test |  | One assessment, during the subacute phase after stroke (3 weeks to 6 months) | 
| Assessment of Executive Function with Verbal and Categorial Fluency test |  | One assessment, during the subacute phase after stroke (3 weeks to 6 months) | 
| Assessment of Executive Functions with the test of commissions |  | One assessment, during the subacute phase after stroke (3 weeks to 6 months) | 
| Assessment of verbal Memory with the verbal span task |  | One assessment, during the subacute phase after stroke (3 weeks to 6 months) | 
| Assessment of verbal Memory with the Grober and Buschke Task |  | One assessment, during the subacute phase after stroke (3 weeks to 6 months) | 
| Assessment of visual Memory with the Doors test |  | One assessment, during the subacute phase after stroke (3 weeks to 6 months) | 
| Assessment of visual Memory with the Rey figure test |  | One assessment, during the subacute phase after stroke (3 weeks to 6 months) | 
| Identification of brain lesions by Anatomical MRI (T1, FLAIR, T2*, Diffusion) |  | up to 6 months | 
| Postural assessment with the PASS |  | 1 month after stroke | 
| Postural assessment with the PASS |  | 3 months after stroke | 
| Gait assessment (Lindmark score) |  | 1 month after stroke | 
| Gait assessment (Lindmark score) |  | 3 months after stroke | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Stroke, Unilateral spatial neglect, MRI, Disconnectome,, Cognition