Anesthetic Efficacy in Irreversible Pulpitis

Study Overview
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Brief Summary
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The purpose of this study was to compare the anesthetic efficacy of articaine, lidocaine and mepivacaine in patients with irreversible pulpitis of mandibular molar.

Detailed Description
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Conventional inferior alveolar nerve block (IANB) is the most commonly used technique for achieving pulpal anesthesia in posterior mandibular endodontic procedures. However, IANB has a high failure rate and success rates are even lower when applied for the treatment of mandibular posterior teeth with irreversible pulpitis.

Official Title
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Anesthetic Efficacy of Articaine, Lidocaine and Mepivacaine in Patients With Irreversible Pulpitis of Mandibular Molar

Conditions
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Anesthesia

Intervention / Treatment
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* Drug: Intervention: inferior alveolar nerve block injection


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: clinical diagnosis of irreversible pulpitis good health had at least 1 adjacent tooth plus a healthy canine Exclusion Criteria: took medication could be interacting with any of the anesthetics used

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: lidocaine<br>injections of 3.6 mL of 2% lidocaine with 1:100,000 epinephrine Intervention: inferior alveolar nerve block injection | Drug: Intervention: inferior alveolar nerve block injection<br>* -22 patients received inferior alveolar nerve block injections of 3.6 mL (equivalent to 2 cartridges)<br>|
| Experimental: mepivacaine<br>injections of 3.6 mL of 2% mepivacaine with 1:100,000 epinephrine Intervention: inferior alveolar nerve block injection | Drug: Intervention: inferior alveolar nerve block injection<br>* -22 patients received inferior alveolar nerve block injections of 3.6 mL (equivalent to 2 cartridges)<br>|
| Experimental: articaine<br>injections of 3.6 mL of 4% articaine with 1:100,000 epinephrine Intervention: inferior alveolar nerve block injection | Drug: Intervention: inferior alveolar nerve block injection<br>* -22 patients received inferior alveolar nerve block injections of 3.6 mL (equivalent to 2 cartridges)<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| pulpal anesthesia | pulpal anesthesia was tested with an electric pulp stimulator | Ten minutes after the inferior alveolar nerve block | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| analgesia | To evaluate the intensity of pain during the pulpectomy a verbal analogic scale was adopted | the patients were instructed to report any painful sensation at three phases: 1) dentin 2) pulp chamber 3) root canal | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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articaine, lidocaine, mepivacaine, inferior alveolar nerve block, irreversible pulpitis