6-minute Stepper Test and Pulmonary Rehabilitation in Patients With Chronicle Obstructive Pulmonary Disease

Study Overview
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Brief Summary
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The purpose of this study is to determine, if it exists, a relation between plateau heart rate from the last 3 minutes of the 6-minute stepper test and heart rate from first ventilatory threshold from cardiopulmonary exercise testing in order to individualise pulmonary rehabilitation in patients with mild to moderate chronicle obstructive pulmonary disease.

Official Title
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Use of the 6-minute Stepper Test to Individualise Pulmonary Rehabilitation in Patients With Mild to Moderate Chronicle Obstructive Pulmonary Disease

Conditions
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Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation, 6-minute Stepper Test

Intervention / Treatment
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* Other: 2 times : 6-minute stepper test with a rest of 20min between each test.


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Age > 18 ans ; Chronicle obstructive pulmonary disease stage I/II (FEV1 ≥ 50%) ; Weight ≤ 90kg ; Eligible for pulmonary rehabilitation. Exclusion Criteria: Pregnant woman or likely to be ; Patient under guardianship ; Contraindication to cardiopulmonary exercise testing ; Patient medically treated with heart rate modulator (excluding oral B2-agonist) ; Patient treated with pacemaker or defibrillator ; History of lower limb impairment (i.e. peripheral artery disease, orthopedic disorder etc.).

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Prospective observational cohort<br>Every patient referred to pulmonary rehabilitation program will be eligible. They will perform cardiopulmonary exercise testing prior to join rehabilitation program. During the first session of pulmonary rehabilitation, they will perform 2 6-minute stepper test with a rest of 20 minutes minimum between each test. | Other: 2 times : 6-minute stepper test with a rest of 20min between each test.<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Relation between plateau heart rate (bpm) from the first and last 3 minutes of the 6-minute stepper test and heart rate (bpm) from first ventilatory threshold from cardiopulmonary exercise testing. | Outcome (heart rate) during different tests will be continuously recorded. Relation will be adjusted for age and step count. | Heart rate (bpm) will be assessed during cardiopulmonary exercise testing with electrocardiogram. During the 2 6-minute stepper test, heart will be assessed with oximeter. All theses tests wil be carried out in a total time frame of 3 month maximum. | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Relation between minimal SpO2 (%)from the 6-minute stepper test and SpO2 (%) from first ventilatory threshold from cardiopulmonary exercise testing. | Outcome (SpO2 (%)) during different tests will be continuously recorded. Relation will be adjusted for age en step count. | SpO2 will be assessed with oximeter. All theses tests wil be carried out in a total time frame of 3 month maximum. | 
| Blood pressure (mmHg) before and after every 6-minute stepper test using electrical blood pressure device. |  | The outcome will be assessed before and after every 6-minute stepper test. The 2 6-minute stepper test will be carried out the same day (minimum 20 minute of rest between each test) for a total time frame of 1 day. | 
| Steps during 6-minute stepper test using stepper device. |  | The 2 6-minute stepper test will be carried out on the same day (20 minute of rest between each test) for a total time frame of 1 day. |