Effects Exercise Training in Patients With Pituitary Adenoma

Study Overview
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Brief Summary
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This study planned to investigate the effects of aerobic training combined with strengthening training and yoga on biochemical factors, physical performance and quality of life in people with pituitary adenoma. The hypotheses are; H1: Aerobic training combined with strengthening training is effective on biochemical factors in people with pituitary adenoma. H2: Aerobic training combined with strengthening training is effective on physical performance in people with pituitary adenoma. H3: Aerobic training combined with strengthening training is effective on quality of life in people with pituitary adenoma. H4: Yoga is effective on biochemical factors in people with pituitary adenoma. H5: Yoga is effective on physical performance in people with pituitary adenoma. H6: Yoga is effective on quality of life in people with pituitary adenoma. H7: Aerobic training combined with strengthening training and yoga is effective on biochemical factors, physical performance and quality of life in people with pituitary adenoma.

Official Title
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Effects of Aerobic Training Combined With Strength Training and Yoga on Biochemical Factors, Physical Performance and Quality of Life in Patients With Pituitary Adenoma

Conditions
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Pituitary Adenoma

Intervention / Treatment
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* Other: Aerobic exercise combined with strength training
* Other: Yoga


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: volunteers macroadenomas at least 1 hormonal axis affected Karnofsky Perfomance Scale between 70-100 18-65 years approved by cardiologists Exclusion Criteria: regular exercise habit acute pain in many part of the body additional neurologic condititons any rheumatological and immunologic conditions

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Group1<br> | Other: Aerobic exercise combined with strength training<br>* 30 minute aerobic exercise training with warm-up and cool down followed by 30 minute strength training for specific muscles.<br>Other: Yoga<br>* 60 minute yoga intervention including different asanas, breath control and meditation<br>|
| Experimental: Group2<br> | Other: Aerobic exercise combined with strength training<br>* 30 minute aerobic exercise training with warm-up and cool down followed by 30 minute strength training for specific muscles.<br>Other: Yoga<br>* 60 minute yoga intervention including different asanas, breath control and meditation<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Biochemical Factors | Concentrations of IL6, IL1beta, TNFalfa in serum | 6 weeks |