Milk and Milk-produce to Counteract the Loss of Muscle Mass and Function in Exercising Older Adults.

Study Overview
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Brief Summary
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This project evaluates the use of different types of proteins from various food sources after an exercise session, on muscle mass and physical capacity in aged sarcopenic men (who have low muscle mass). Specifically, researchers want to: Examine the efficiency of protein intake after exercise on muscle mass and physical abilities; Examine the impact of exercise and proteins on blood lipids (LDL cholesterol, HDL cholesterol, total cholesterol and triglycerides); Examine the impact of exercise and proteins on liver enzymes; Examine the impact of exercise and proteins on a hormone that controls hunger; Evaluate the program's impact on the ability of the body to produce energy. All participants are exercising (resistance training) and ingest one of the 3 different sources of proteins, immediately after training: Milk proteins (from milk beverage) Essential amino acids (added to a soya beverage) No protein (rice beverage - control group) Our hypothesis is that proteins from milk will induce a gain in muscle mass and physical function equivalent to the essential amino acids (EAA). We anticipate that both milk proteins and EAA will be both superior to control group. This would represent an interesting finding since milk is more accessible, palatable and cheaper than essential amino acids commercial mix.

Official Title
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Milk and Milk-produce to Counteract the Loss of Muscle Mass and Function in Exercising Older Adults.

Conditions
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Sarcopenia

Intervention / Treatment
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* Other: Resistance training


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 65-75 years francophone or understanding French muscle mass index < 10.75 kg/m2 (Janssen et al, 2004) body mass index <30kg/m² weight stable (< 2 kg) for 6 mo no resistance exercise for 3 years controlled blood pressure for at least 6 months Exclusion Criteria: major physical disability medical treatment influencing metabolism statin treatment diagnosis or any sign of kidney disease

Ages Eligible for Study
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Minimum Age: 65 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Milk proteins<br>This group will do a resistance training + milk proteins (milk beverage) | Other: Resistance training<br>* All group will exercise 3x/week. Each session of resistance training will last 60min. and will target main muscular groups.<br>|
| Experimental: Essential amino acids (add to soya bvg)<br>This group will do a resistance training + essential amino acids (added to soya beverage) | Other: Resistance training<br>* All group will exercise 3x/week. Each session of resistance training will last 60min. and will target main muscular groups.<br>|
| Placebo Comparator: No protein (control)<br>This group will do a resistance training + ingestion of the control beverage (no protein, rice beverage) | Other: Resistance training<br>* All group will exercise 3x/week. Each session of resistance training will last 60min. and will target main muscular groups.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Muscle mass |  | At baseline and post intervention (17th week) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Relative strength |  | At baseline and post intervention (17th week) | 
| Blood markers of inflammation | Plasmatic IL-6 anf TNF-alpha | At baseline and post intervention (17th week) | 
| Plasma Lipid profile | Apolipoproteins (Apo-AI, Apo-AII, Apo-B); Total cholesterol, HDL, LDL and triglycerides. | At baseline and post intervention (17th week) | 
| Plasma creatinine | Blood marker on renal function will be assessed to ensure the safety of the supplementation of protein intake on renal function in sarcopenic men. | At baseline, mid (8th week) and post intervention (17th week) | 
| Blood markers of fatty liver | Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT) and Alkaline phosphatase (ALP). | At baseline and post intervention (17th week) | 
| extracellular HSP72 |  | At baseline and post intervention (17th week) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sarcopenia, Physical capacity, Muscle force, Muscle quality, Milk proteins, Essential amino acids, Proteins, Resistance training, Exercise