Utilizing Smart Devices to Identify New Phenotypical Characteristics in Movement Disorders

Study Overview
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Brief Summary
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This observational and experimental study seeks to establish a Smart Device System (SDS) to monitor high-resolution handtremor-based data using Smartphones, SmartWatches and Tablets. By doing this, movement data will be analyzed in depth with advanced statistical and Deep-Learning algorithms to identify new clinical phenotypical characteristics Parkinson's Disease and Essential Tremor.

Detailed Description
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Current smart devices as smartphones and smartwatches have reached a level of technical sophistication that enables high-resolution monitoring of movements not only for everyday sports activities but also for movement disorders. Tremor-related diseases as Parkinson's Disease (PD) and Essential Tremor (ET) are two of the most common movement disorders. Disease classification is primarily based on clinical criteria and remains challenging. The primary goal of this study is to identify new phenotypical characteristics based on the captured movement data by the tremor-capturing smartwatches and tablets and smartphone-based questionnaires. The system will be applied and analyzed within an experimental and observational setting and only captures from patients, which have received informed consent. Within the study period, the SDS is not intended as clinical diagnostic support for physicians and will be not be used as medical device.

Official Title
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Utilizing Smart Devices to Identify New Phenotypical Characteristics in Movement Disorders

Conditions
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Parkinson Disease, Essential Tremor, Movement Disorders, Parkinson's Syndrome, Atypical Parkinsonism

Intervention / Treatment
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* Other: Data Capture


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed with Parkinson's Disease (ICD-10-GM G20.-) or Essential Tremor (G25.0) Comparison group: Other movement disorders including atypical Parkinsonian disorders and healthy participants Exclusion Criteria: Unable to obtain informed consent Skin-related conditions at one of the wrists or any other medical conditions that could harm the participant's health by wearing the smartwatch at both wrists.

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Parkinson's Disease<br>Participant's diagnosed with Parkinson's Disease | Other: Data Capture<br>* This is no intervention. Participants of all groups will receive data Capture with smartphones, smartwatches and tablets.<br>|
| Essential Tremor<br>Participant's diagnosed with Essential Tremor or other Movement Disorders | Other: Data Capture<br>* This is no intervention. Participants of all groups will receive data Capture with smartphones, smartwatches and tablets.<br>|
| No Parkinson's Disease and No Essential Tremor<br>Participant's with no diagnosis of PD, ET or other Movement Disorders | Other: Data Capture<br>* This is no intervention. Participants of all groups will receive data Capture with smartphones, smartwatches and tablets.<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Acceleration data in all three axes (x,y,z) measured at both wrists via Smartwatches during 10 minutes of neurological examination. Aggregated data: Mean Frequency and Amplitude of Tremor. | The raw time series data (acceleration data) and the aggregated data will be analyzed to train a neural network to classify the participant's movement disorder. | 2018-2020 |