CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy: an International Registry (DERIVATE)

Study Overview
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Brief Summary
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The DERIVATE study was conceived to integrate the information resulted from clinical data, transthoracic echocardiography, and cardiac magnetic resonance (CMR) imaging to provide a more reliable risk stratification in patients affected by heart failure (HF) and worthy of prophylactic implanted cardioverter defibrillator (ICD) therapy. The main purposes of this multicenter registry are to: 1) determine CMR findings, and specifically late gadolinium enhancement (LGE) features, T1 mapping, and extracellular volume (ECV) that predict sudden cardiac death (SCD) and ventricular arrhythmia; 2) provide a comprehensive clinical and imaging score that effectively improves the selection of patients who deserve a prophylactic ICD therapy; 3) evaluate the contribution of machine learning to predict major adverse cardiac events (MACE) as compared to standard clinical scores.

Detailed Description
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The current guidelines provide indications for primary prevention implanted cardioverter defibrillator (ICD) therapy based on left ventricle ejection fraction (LVEF) and New York Heart Association (NYHA) class. This strategy is able to intercept only part of fatal arrhythmic events and, on the other hand, led to useless ICD implantations mainly among those patients with severe heart failure (HF) who will never incur in sever arrhythmias but rather will die because of decompensated HF. Cardiac magnetic resonance offers the possibility of identifying and quantitatively assessing myocardium fibrosis both localized in a specific area and diffuse and has already proved a significant prognostic meaning. DERIVATE is a prospective, international, multicenter, observational registry of stable HF patients with reduced LVEF who underwent clinical evaluation, transthoracic echocardiography (TTE) and cardiac magnetic resonance (CMR). Specifically, the primary aim of DERIVATE is to determine CMR findings that predict outcomes, with incremental value over LVEF and NYHA classification. The DERIVATE registry uses a collaborative design with contribution and merger of similar prospectively enrolled cohorts from 33 sites in 6 countries in Europe and North America. The targeted population for the DERIVATE registry is a large sample of patients with clinical history of chronic HF who have undergone CMR by referral physician. Indication for CMR exams was recorded and classified according to the known causes of HF. All DERIVATE study patients are followed for all-cause mortality, sudden cardiac death (SCD), cardiovascular death (including death caused by acute myocardial infarction and stroke), sustained ventricular tachycardia (VT), aborted SCD, hospitalization or cardiac death related to chronic HF. The follow up minimum period is 12 months. Complete risk factors, clinical presentation, echocardiography and CMR data recording, and follow-up for all-outcomes will contribute data for common analysis.

Official Title
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CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy: an International Registry

Conditions
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Heart Failure, Left Ventricular Systolic Dysfunction

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Heart Failure patients (according to the ACC/AHA classification) with known ischemic cardiomyopathy (ICM) or non ischemic dilated cardiomyopathy (DCM) reduced left ventricle ejection fraction (LVEF) (<50%) Exclusion Criteria: pregnancy current alcohol or drug abuse unstable angina decompensated HF (NYHA class IV) in the previous 1 month acute myocarditis in the previous 3 months recent myocardial infarction (MI) (<40 days) or) severe valvular disease cardiac amyloidosis hypertrophic cardiomyopathy arrhthmogenic right ventricular cardiomyopathy takotsubo cardiomyopathy congenital heart disease non CMR compatible device estimated glomerular filtration rate ≤30 mL/min/1.73m2 other contraindication to gadolinium contrast agent severe claustrophobia participating in other trials with an active treatment arm (not to exclude patients who are in trials of diagnostic techniques or approved therapies) unwilling or unable to provide informed consent.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| all-cause mortality |  | The follow up minimum period is 12 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| sudden cardiac death (SCD) |  | The follow up minimum period is 12 months | 
| aborted sudden cardiac death (SCD) |  | The follow up minimum period is 12 months | 
| heart failure (HF) death |  | The follow up minimum period is 12 months | 
| sustained ventricular tachycardia (VT) |  | The follow up minimum period is 12 months | 
| major adverse cardiac events (MACE) | composite end point of SCD, aborted SCD, cardiovascular death, and sustained VT | The follow up minimum period is 12 months |