Stellate Ganglion Block on Tourniquet Response

Study Overview
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Brief Summary
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To investigate the influence of stellate ganglion block on tourniquet response during surgery in patients undergoing elective lower limb Department of orthopedics.

Detailed Description
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Select elective general anesthesia in 100 cases of lower extremity Department of orthopedics surgery patients were randomly divided into SGB group and control group, SGB group received anesthesia before the right stellate ganglion block intervention, the control group underwent right deltoid muscle injection, changes in hemodynamics in two groups were recorded in heart rate, blood pressure, and before anesthesia, after intubation 3min 1H, a tourniquet, tourniquet release before and after tourniquet release 3min, 30min, changes in blood physiological analysis. The effect of stellate ganglion block on tourniquet response during perioperative period was observed.

Official Title
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Influence of Stellate Ganglion Block on Tourniquet Response in Lower Limbs.

Conditions
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Stellate Ganglion Block

Intervention / Treatment
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* Procedure: Stellate ganglion block
* Procedure: control group


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: American Society of anesthesiologists Grade 1-3 Patients undergoing lower limb surgery under general anesthesia should be treated with tourniquet Exclusion Criteria: Tourniquet application time is less than 1h, greater than 1.5h Abnormal coagulation function perioperative application of hormone lidocaine allergy can not cope with nerve block nerve block failure minimally invasive surgery

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 75 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Stellate ganglion block<br>Stellate ganglion block | Procedure: Stellate ganglion block<br>* Stellate ganglion block with 1% lidocaine 10ml<br>|
| Placebo Comparator: control group<br>Deltoid muscle injection | Procedure: control group<br>* Deltoid muscle injection with 1% lidocaine 10ml<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| blood pressure | mmHg | 2 hours in perioperative period | 
| heart rate | bpm | 2 hours in perioperative period | 
| Lac | blood gas analysis mmol/L | One minute after the radial artery puncture, the tourniquet was applied for 1 hours and the tourniquet was released 3 minutes after the tourniquet release 30 minutes | 
| cortisol | ELISA ng/ml | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet | 
| norepinephrine | ELISA nmol/L | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet | 
|  | n nitrate reductase method μmol/L | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet | 
| ET-1 | ELISA ng/L | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet | 
| MDA | ELISA nmol/ml | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet | 
| SOD | ELISA μg/L | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet | 
| IL-6 | ELISA pg/ml | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet | 
| cTn-T | ELISA μg/L | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet | 
| postoperative pain | VAS score | hour 1、hour 6、hour 24、hour 48 after operation | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Complication of puncture | bleeding、nerve injury、 | 2 hours in perioperative period | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Stellate ganglion block Tourniquet reaction