MRI & QST Analysis in Trigeminal Neuralgia and Persistent Idiopathic Facial Pain

Study Overview
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Brief Summary
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Patients with a definite diagnosis of classical TGN and PIFP will undergo a structured clinical questionnaire and a trigeminal sensory profile using the quantitative sensory testing. Clinical measures and sensory profiles will be correlated with MRI measures.

Detailed Description
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Patients with a definite diagnosis of classical TGN and PIFP (according to the 2020 ICOP Classification) will undergo a structured clinical questionnaire and a trigeminal sensory profile using the quantitative sensory testing. Clinical measures and sensory profiles will be correlated with the presence and the geometry of neurovascular compression at MRI. Moreover quantitative structural neuroimaging analysis, such as trigeminal root volume, will be performed in each patient and correlated with clinical and QST data.

Official Title
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Assessing Somatosensory System Damage in Trigeminal Neuralgia and Persistent Idiopathic Facial Pain Through Neuroimaging and Quantitative Sensory Testing

Conditions
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Facial Pain

Intervention / Treatment
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* Other: Quantitative Sensory Testing


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Definite diagnosis of Classical or Idiopathic Trigeminal Neuralgia or Persistent Idiopathic Facial Pain according to the latest ICOP 2020 Criteria Naive to any surgical procedures Exclusion Criteria: Any major chronic painful or other neurological disease Diagnosis of Secondary Trigeminal Neuralgia Diagnosis of other facial pain syndromes Cognitive disturbances
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Trigeminal Neuralgia<br>Patients with a definite diagnosis of Classical or Idiopathic Trigeminal Neuralgia | Other: Quantitative Sensory Testing<br>* Non-invasive assessment of Sensory Profile<br>|
| Persistent Idiopathic Facial Pain<br>Patients with a definite diagnosis of Persistent Idiopathic Facial Pain | Other: Quantitative Sensory Testing<br>* Non-invasive assessment of Sensory Profile<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Sensory Profile | Sensory Profile as assessed by Quantitative Sensory Testing | Baseline, at the time of visit | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Presence of Neurovascular Compression | Presence of Neurovascular Compression defined as absence of any liquor cleft between the trigeminal root and the offending vessel, on dedicated Trigeminal MRI | Baseline, at the time of visit | 
| Trigeminal Root Volume | Trigeminal Root Volume as assessed by specific neuroimaging Software (MIPAV) | Baseline, at the time of visit | 
| Geometry of Neurovascular Compression | Measurement of the polar coordinates beetween the trigeminal root and the offending vessel as assessed by specific neuroimaging Software (MIPAV) | Baseline, at the time of visit |