Tapfinger Psychomotor Target

Study Overview
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Brief Summary
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The study aims at mapping the magnetoencephalographic (MEG) activities induced in normal volunteers by tapping the finger .

Detailed Description
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Normal healthy (20) volunteers and tetraplegic patients(10) will be submitted to the temporo-spatial mapping of their brain activity, both sensory and motor, induced by a simple behavioral task, consisting on tapping with the finger on a detection pad. This will be done in a light and then dark environment, on a rythm spontaneous and then paced by sound bips. Accelerometric recording will provide the three dimensionnal displacements of the finger as well as the time code. Brain activity is simultaneously recorded using MEG (306 channels) and EEG (64 channels. Data will be processed by an INPLS algorithm to detect the predictors of activity, their location and time-course. 3D mapping data will be matched with the patient's anatomy provided by 1.5T MRI previously performed. The aim of the study is to prepare the strategy of implantation of multielectrodes ECoG implants to restore motility in tetraplegic patients in a human BCI protocol currently under development.

Official Title
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MagnetoEncephaloGraphy Study of Cerebral Activations Induced by Psychomotor Tasks for Target Localisation in View of BCI Clinical Trial

Conditions
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Functional Brain Mapping

Intervention / Treatment
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* Behavioral: Psychomotor tasks


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Male or Female between 18 and 70 years Informed consent Benefiting from Social Security French or english speaking, to understand study procedure Tetraplegic patients : traumatic injury of the cervical spine with retained respiratory autonomy and without associated head injury Exclusion Criteria: Contra-indication to MRI Claustrophobia Mental disorders Pregancy All categories of protected persons

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Other
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Psychomotor tasks<br>20 healthy subjects and 10 tetraplegic patients will participate to acquisition of MEG, EEG, MRI data during a motor tasks | Behavioral: Psychomotor tasks<br>* the acquisition of data will be performed in one unique session no drug administration no surgery<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MEG records for functional brain mapping | This study is not a therapeutic clinical study. No treatment is being delivered. | one hour study | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MEG measurements during psychomotor tasks | MEG records induced by finger tapping will be performed either randomly or following sound bips pacing. | one hour study | 
| EEG measurements during psychomotor tasks | EEG records induced by finger tapping will be performed either randomly or following sound bips pacing. | one hour study | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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EEG, MRI, Brain mapping, functional imaging, brain computer interface, MEG