Prospective Memory Imaging

Study Overview
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Brief Summary
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The purpose of this study is to investigate prospective merory (memory of intentions) in healthy controls and in aMCI (amnestic Mild Cognitive Impairment) and AD (Alzheimer Disease) patients.

Official Title
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Cerebral Substrates of Prospective Memory in Healthy Young Adults and Disruptions in Normal Aging and Alzheimer Disease: a Study in Anatomical, Functional and Diffusion Tensor MRI.

Conditions
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Alzheimer Disease

Intervention / Treatment
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* Behavioral: Memory assessment
* Other: Structural MRI
* Other: Functional MRI
* Other: Virtual reality / Memory assessment


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria : Education level > 7 years Native language: French Beck < 7 Medical, neurological, neuropsychological and neuroradiological depth in accordance with the criteria for inclusion and exclusion-specific population, that is to say: Young Healthy Subjects: between 18 and 44 years old; Middle age Healthy Subjects: between 45 and 69 years old; without memory complaints, normal performances compared to the age and the educational level for all tests of the diagnostic battery. Elderly Healthy Subjects: over 70 years old, without memory complaints, normal performances compared to the age and the educational level for all tests of the diagnostic battery. MCI patients: over 50 years old, presenting the current criteria for amnestic MCI including: i) memory complaint, ii) deficits of the episodic memory (lower performance of at least 1 SD from the norm for age and cultural level for one or more scores of episodic memory and iii) normal performances compared to the age and the educational level of all other cognitive functions as memory, including tests to assess cognitive abilities. Alzheimer's patients: over 50 years old, presenting the standard criteria of NINCDS-ADRDA probable Alzheimer's disease, including abnormal global cognitive function and deficits in at least two cognitive domains identified by the diagnostic battery and a mild to moderate Alzheimer's disease (MMSE ≥ 18). Exclusion Criteria : The sudden onset of cognitive impairments (as opposed to their slow and gradual installation in Alzheimer's disease) A chronic neurological, psychiatric, endocrine, hepatic or infectious complaint A history of major disease (a lung, heart, metabolic, hematologic, endocrine disease or a severe cancer); A medication that may interfere with memory or metabolic measures A alcohol or drugs abuse claustrophobia, metallic object in the body A predominantly left-hand (score below 50% in Edinburgh Inventory). Protected adults, and persons not affiliated with a social security system will not participate in this study. Pregnant or suckling women The inclusion of a participant in another biomedical research protocol (during the study or within 12 months before inclusion)

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Non-Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Young Healthy Subjects<br> | Behavioral: Memory assessment<br>* Neuropsychological tests including clinical and original tests to compare differences between each populations<br>Other: Structural MRI<br>* to compare differences between each populations<br>Other: Functional MRI<br>* to compare differences between each populations<br>Other: Virtual reality / Memory assessment<br>* to compare differences between each populations<br>|
| Experimental: Middle age Healthy Subjects<br> | Behavioral: Memory assessment<br>* Neuropsychological tests including clinical and original tests to compare differences between each populations<br>Other: Structural MRI<br>* to compare differences between each populations<br>Other: Functional MRI<br>* to compare differences between each populations<br>Other: Virtual reality / Memory assessment<br>* to compare differences between each populations<br>|
| Experimental: Elderly Healthy Subjects<br> | Behavioral: Memory assessment<br>* Neuropsychological tests including clinical and original tests to compare differences between each populations<br>Other: Structural MRI<br>* to compare differences between each populations<br>Other: Functional MRI<br>* to compare differences between each populations<br>Other: Virtual reality / Memory assessment<br>* to compare differences between each populations<br>|
| Experimental: Mild Cognitive Impairment patients<br> | Behavioral: Memory assessment<br>* Neuropsychological tests including clinical and original tests to compare differences between each populations<br>Other: Structural MRI<br>* to compare differences between each populations<br>Other: Functional MRI<br>* to compare differences between each populations<br>Other: Virtual reality / Memory assessment<br>* to compare differences between each populations<br>|
| Experimental: Alzheimer Disease patients<br> | Behavioral: Memory assessment<br>* Neuropsychological tests including clinical and original tests to compare differences between each populations<br>Other: Structural MRI<br>* to compare differences between each populations<br>Other: Functional MRI<br>* to compare differences between each populations<br>Other: Virtual reality / Memory assessment<br>* to compare differences between each populations<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Rate of volume change of whole brain and other structural MRI measures |  | 1 Month | 
| Cerebral regions implicated in prospective memory observed by functional MRI |  | 1 Month | 
| Episodic memory as measured by Cognitive Tests |  | 18 Months | 
| Virtual reality evaluation of prospective memory |  | 1 Month | 
| Group differences for each imaging and neuropsychological measurement |  | 1 Month | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Prospective Memory, Healthy Aging, Alzheimer Disease, Brain Imaging