Tooth Graft of Two Different Particle Sizes in Extraction Sockets

Study Overview
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Brief Summary
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The primary objective of the present study is to clinically and radiographically evaluate the efficacy of autogenous tooth graft obtained from bone mill and dental grinder to preserve alveolar ridge dimensions in extraction sockets.

Detailed Description
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Accordingly, teeth will be used as a test material to allow for comparative tests after processing it in the automated milling system (AMS). The material will be moistened and then placed in toto into the extraction sockets to generate particles at settings 1 (500 RPM for 30s) or 2 (900 RPM for 30s) to generate MS and SS respectively ((SS group; 0.5-0.8 mm) and medium size (MS group; 1.0-1.2 mm)).

Official Title
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Comparison of Autogenous Tooth Graft of Two Different Particle Sizes in Extraction Socket Preservation: A Comparative Clinical and Radiographical Study

Conditions
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Socket Preservation

Intervention / Treatment
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* Device: Dentin grinder
* Device: Bone mill


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Systemically healthy individuals within the age group of 20-50 years with presence of teeth with hopeless prognosis requiring extraction Exclusion Criteria: Medically compromised patients. Subjects who underwent radiotherapy or chemotherapy in the past 12 months. Patients having uncontrolled periodontal disease or having an active sinus infection. Smokers

Ages Eligible for Study
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Minimum Age: 20 Years
Maximum Age: 50 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Dentin chips group from automated mill<br>Dentin particles prepared from dentin grinder will be placed in extraction socket immediately after extraction | Device: Dentin grinder<br>* After atraumatic extraction of the tooth, autogenous dentin particles are made with the help of a device - dentin grinder from the separated root and these particles are incorporated into the extraction socket<br>|
| Active Comparator: Manually milled Dentin chips<br>Dentin particles prepared from bone mill will be placed in extraction socket immediately after extraction. | Device: Bone mill<br>* After atraumatic extraction of the tooth, autogenous dentin particles are made with the help of a device - Bone mill from the separated root and these particles are incorporated into the extraction socket<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Bone fill | The radiograph obtained at 3 and 6 months will be subtracted from the radiograph taken at the baseline by using commercially available image processing software (Adobe Photoshop® 6.0, Adobe Systems, San Jose, USA). After digital subtraction, the digitized and excluded residual bone height will be transferred to open source software for area calculation (ImageJ®, Research Services Branch, NIH, Bethesda, Maryland, USA) for area calculation. The area of the layer will be calculated (in mm2) by initially enclosing the entire area with the rectangular selection tool and then by using Analyze>Analyze Particles tool. | Baseline to 6months | 
| Bone density | Radiographs will be taken with digitalized RVG machine (DX 3000, DEXCOWN portable dental X-ray system) at 60Kvp/2Ma with inactive interface. RVG images taken at baseline and 6 months will be utilized to evaluate bone mineral density through Hounsfield units (HU). | Baseline to 6months |