Basal Cell Carcinoma Recurrence After Mohs Surgery

Study Overview
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Brief Summary
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Basal cell carcinoma (BCC) is the most common skin cancer in the US and can cause significant adverse effects. Mohs micrographic surgery, the treatment of choice for higher risk BCC, allows for removal of lesions with preservation of healthy tissue. Although the BCC recurrence rate post Mohs surgery is estimated at 1-2%, recent data is lacking to validate this historical measurement. Our purpose is to determine the current recurrence rate of BCC after Mohs surgery.

Detailed Description
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Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer in the United States, affecting nearly one million of all Americans. While BCC is rarely mortal, it has significant associated physical, psychological, and monetary costs to patients such as disfigurement and sensory loss. Individuals who have been diagnosed with at least one BCC lesion are likely to be diagnosed with more in the future. Treatment of these lesions and recurrent physician appointments can be a great inconvenience to patients, resulting in expenses to patients and loss of work and family time. The Mohs surgery technique is associated with a low recurrence rate for BCC and is preferred for higher risk tumors and for tumors in cosmetically sensitive sites on the head and neck. While recurrence rates of BCC post Mohs are 1-2% for primary basal cells, recent data is not available to validate this historical assessment. Currently, comprehensive rates of recurrence are not available because a national registry of recurrence rates for BCC and squamous cell carcinoma (SCC) does not exist. The purpose of this study is to both historically and prospectively assess current basal cell carcinoma recurrence rates in patients undergoing Mohs micrographic surgery.

Official Title
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Basal Cell Carcinoma Recurrence

Conditions
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Basal Cell Carcinoma

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Subjects with BCC lesions on the head, neck, genitalia, hands, or feet Subjects who have undergone Mohs micrographic surgery for BCC on or before December 31, 2006 Subjects with a medical record at the respective site Subjects in a stable health condition, as determined by the principle investigator Exclusion Criteria: Subjects with basal cell nevus syndrome Subjects with lesions only in areas other than the head, neck, genitalia, hands and feet Subjects who have not followed up through the Department of Dermatology Subjects with recurrent BCC lesions diagnosed on or prior to the recorded date of Mohs surgery

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Historical Arm<br>266 cases of BCC treated with Mohs surgery approximately 2-5 years ago will be assessed for recurrence. | |
| Prospective Arm<br>300 cases of BCC will be followed annually for 3 years after Mohs surgery to assess for recurrence. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Recurrence of BCC |  | either after 1 study visit (historical arm), or 3 years (prospective arm) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Risk Factors for recurrence of BCC |  | either after 1 study visit (historical arm), or 3 years (prospective arm) | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Skin Cancer, Basal Cell, Mohs surgery