Comparison of Erector Spinae Plane Block With Thoracic Paravertebral Block for Breast Surgery

Study Overview
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Brief Summary
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Postoperative analgesia in breast surgery is a difficult and overworked issue due to etensive surgery and complex innervation of the breast. Erector spinae plane block (ESB) is a new defined and promising regional anesthesia technique for thoracic analgesia. Main purpose of this study is to compare the analgesic effect of ultrasound guided ESB with thoracic paravertebral block - the golden standard method for postoperative regional analgesia technique in breast surgery.

Official Title
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Comparison of Erector Spinae Plane Block With Thoracic Paravertebral Block for Breast Surgery

Conditions
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Postoperative Pain, Breast Cancer

Intervention / Treatment
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* Device: Intravenous morphine patient controlled device
* Other: Erector Spinae Plane Block
* Other: Thoracic Paravertebral Block


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: 25-70 years of agge ASA I-II Undergoing elective breast cancer surgery Exclusion Criteria: obesity (body mass index >35 kg/m2) infection of the skin at the site of needle puncture area patients with known allergies to any of the study drugs coagulopathy recent use of analgesic drugs

Ages Eligible for Study
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Minimum Age: 25 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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Female

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Prevention
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: ESP group<br>Erector Spinae Plane Block administered group | Device: Intravenous morphine patient controlled device<br>* 24 hour morphine consumption will be recorded<br>Other: Erector Spinae Plane Block<br>* erector spinae plane block will be administered before the surgery<br>|
| Active Comparator: TPVB group<br>Thoracic Paravertebral Block administered group | Device: Intravenous morphine patient controlled device<br>* 24 hour morphine consumption will be recorded<br>Other: Thoracic Paravertebral Block<br>* thoracic paravertebral block will be administered before the surgery<br>|
| Other: Control Group<br>No regional anesthesia technique will be applied to control group; but will be provided with iv PCA | Device: Intravenous morphine patient controlled device<br>* 24 hour morphine consumption will be recorded<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Morphine consumption | All patients will be provided with IV morphine PCA and morphine consumption after 24 hour postoperatively will be recorded. | 24 hour postoperatively | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Numering Rating Scale scores for pain | Numeric Rating Scale (NRS) for pain will be used. The Numeric Rating Scale (NRS-11) is an 11-point scale for patient self-reporting of pain. It is for adults and children 10 years old or older. 0 means no pain and 10 means most imaginable pain | 24 hour | 
| Postoperative nausea and vomiting | Incidence of postoperative nausea and vomiting will be recorded | 24h | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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erector spinae plane block, thoracic paravertebral block, breast surgery, postoperative pain