Strength Training and Different Subtypes of Parkinson´s Disease

Study Overview
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Brief Summary
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The aim of this randomized controlled trial was to assess the impact of progressive resistance exercise (PRE) in PD patients with akinesia and rigidity (AR-subtype). The investigators hypothesized the intervention would have a beneficial effect on the study outcomes.

Detailed Description
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Twenty-eight patients with PD AR-type of both sexes, were recruited for this trial. Each participant were assigned randomly to either intervention (N=13) or control (N=15) group. The intervention group participated in sixteen PRE training sessions for eight weeks: two sessions per week on non-consecutive days, sixty-seventy min each one. The control group followed their usual weekly physical activity routine. All patients underwent antrophometrical and neuromuscular function assessment (CoP measurements -primary outcomes- and the Ten-Meters Walk Test -TMWT- -secondary outcomes-). In addition, they were asked to provide ratings for the Spanish validated versions of the the Freezing of Gait Questionnaire (FOG-Q, 6-item version) -secondary outcomes-, the 39-item Parkinson ́s disease Questionnaire (PDQ39) -secondary outcomes- and the MDS-UPDRS -secondary outcomes-. Additionally, ratings of perceived exertion (RPE) (Borg >6-20 scale) - secondary outcomes-, were recorded at the end of each PRE training session. Tests were carried out at three times: pre-test (before the training program), post-test (eight weeks after pre-tests, at the end of the training period), and four weeks after the post-test (re-test).

Official Title
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Effects of Progressive Resistance Exercise in Akinetic-rigid Parkinson's Disease Patients

Conditions
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Parkinson Disease

Intervention / Treatment
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* Other: Progressive resistance exercise
* Other: Physical Activity


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Diagnosed with PD AR-type and Hoehn and Yahr Scale 1-2, (H&Y) Do not express any type of dementia Able to stand for two min without assistance; Able to walk ten metres without assistance. Exclusion criteria: To suffer a neurological disease other than PD. Do not meet some of the inclusion criteria.
Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Supportive Care
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Progressive resistance exercise (PRE)<br>Progressive resistance exercise (PRE) in akinetic-rigid Parkinson's disease patients. Intervention included sixteen PRE training sessions for eight weeks: two sessions per week on non-consecutive days, sixty-seventy min each one. | Other: Progressive resistance exercise<br>* The intervention group participated in sixteen PRE training sessions for eight weeks: two sessions per week on non-consecutive days, sixty-seventy min each one.<br>Other: Physical Activity<br>* The control group followed its usual weekly physical activity routine<br>|
| No Intervention: Physical Activity<br>The control group followed its usual weekly physical activity routine | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Static posturography through the centre of pressures measurements (CoP). |  | Eight weeks | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Gait. |  | Eight weeks | 
| Freezing of gait. |  | Eight weeks | 
| The Movement Disorders Society-Unified Parkinson ́s Disease Rating Scale. (MDS-UPDRS). |  | Eight weeks | 
| The patient- perceived quality of life. |  | Eight weeks |