Effect of Radical Prostatectomy on Involuntary Pelvic Floor Muscle Contraction

Study Overview
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Brief Summary
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This study evaluate the effect of radical prostatectomy on involuntary pelvic floor muscle contraction

Detailed Description
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Radical prostatectomy may cause stress urinary incontinence (SUI). That poses problem in terms of quality of life. There are many treatment options available for patients with SUI, but the exact mechanism is not known. We compared, in continent and incontinent men post-radical prostatectomy, the correlation between the temporal course of pelvic floor activation during cough. Simultaneously, recordings of electromyographic activity of external anal sphincter (EAS EMG) and external intercostal muscle (EIC EMG) during coughing will be made with a pair of pre-gelled electrodes. Cough effort cause an involuntary pelvic contraction. Intercostals muscles recording was chosen because they are one of the muscular components of cough initiation with diaphragm muscle. 24h pad-weighing test is used to quantify urinary incontinence. We will measure the latency between the onset of the EIC EMG and the EAS EMG (RT3), during a cough effort. We will also measure the duration of the contraction, the maximum EAS EMG activity and the area under the curve.

Official Title
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Effect of Radical Prostatectomy on Involuntary Pelvic Floor Muscle Contraction

Conditions
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Lower Urinary Tract Symptoms

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Follow in neuro-urology for lower urinary tract symptoms Radical Prostatectomy Exclusion Criteria: Perineal Radiotherapy Surgery for stress urinary incontinence

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 100 Years

Sexes Eligible for Study
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Male

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Latency (time) | The time (latency) between the onset of the external intercostal muscle (EIC EMG) and the electromyographic activity of external anal sphincter (EAS EMG), during a cough effort. | 1 day: During electromyographic recording | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration (time) | The duration of contraction of external anal sphincter (defined as the time between the onset of the electromyographic activity of external anal sphincter and the end of the electromyographic activity of external anal sphincter). | 1 day: During electromyographic recording | 
| Maximum | The maximum of contraction of the electromyographic activity external anal sphincter. | 1 day: During electromyographic recording | 
| Area under the curve | the area under the curve of the electromyographic activity external anal sphincter. | 1 day: During electromyographic recording | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Radical prostatectomy, urinary incontinence, pelvic floor muscle, reaction time