Anemia and Duration of Mechanical Ventilation

Study Overview
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Brief Summary
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In mechanically ventilated patients in intensive care unit, anemia is commonly seen and it is probably associated with adverse outcomes including mortality. We aim to investigate the impact of duration of anemia and the duration of mechanical ventilation as well as clinical outcomes in critically ill patients in intensive care unit who required ventilatory support >96 hr.

Detailed Description
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Anemia is one of the most common conditions encountered critically ill patients. Various mechanisms can put these patients at risk of anemia including gastrointestinal hemorrhage, iron deficiency, inflammation and infection, stress, and multiple blood testing. Anemia can affect cardiopulmonary function as depletion in oxygen content in body. In mechanically ventilated patients, anemia is associated with increased duration of mechanical ventilation, increased length of stay, and possibly increased mortality. Some research suggested that hemoglobin level <8.5 g/dl was a potential risk factor for adverse outcome in critically ill patients required mechanical ventilation >96 hr. However, most researches focused on hemoglobin levels and the associated adverse events in mechanically ventilated patients. To the best of our knowledge, there are few studies reported the impact of the duration of anemia and the clinical outcomes in these patients. We hypothesize that the short duration of anemia developed in mechanically ventilated patients has no effect on duration of mechanical ventilation. We, therefore, aim to investigate the impact of the duration of anemia on duration of mechanical ventilation in critically ill patients required ventilatory support >96 hours.

Official Title
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The Correlation Between Period of Anemia and Duration of Mechanical Ventilation in Patients Admitted to the Surgical Intensive Care Unit

Conditions
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Morality, Anemia, Mechanical Ventilation, Critically Ill, Intensive Care Unit, Organ Dysfunction Syndrome

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients whose age of equal or more than 18 years old Patients admitted to the surgical intensive care unit during the study period Patients required ventilatory support with invasive mechanical ventilation for more than 96 hours Exclusion Criteria: Patients whose data regarding time of beginning or ending of ventilatory support missed Patients who are previously included in this study and are re-admitted

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of mechanical ventilation | Days patients received mechanical ventilation | 28 days after initiation of ventilatory support | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Duration of anemia | Days patients had hemoglobin level <8 g/dl while they were on ventilatory support | 28 days after initiation of ventilatory support | 
| Cardiovascular dysfunction | SOFA cardiovascular component equal to 1, 3, or 4 | 28 days after initiation of ventilatory support | 
| Respiratory dysfunction | SOFA respiratory component >1 | 28 days after initiation of ventilatory support | 
| Renal dysfunction | SOFA respiratory component >1 | 28 days after initiation of ventilatory support | 
| Gastrointestinal dysfunction | SOFA gastrointestinal component >1 | 28 days after initiation of ventilatory support | 
| Hematologic dysfunction | SOFA hematologic component >1 | 28 days after initiation of ventilatory support | 
| ICU length of stay | Duration from ICU admission to ICU discharge | Up to 90 days following inclusion | 
| Hospital length of stay | Duration from hospital admission to hospital discharge | Up to 90 days following inclusion | 
| ICU mortality | Status at ICU discharge either alive or deceased | Up to 90 days following inclusion | 
| Hospital mortality | Status at hospital discharge either alive or deceased | Up to 90 days following inclusion | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Duration of mechanical ventilation, Duration of anemia, Intensive care unit, Mortality, Organ dysfunction