the Association Between Thyroid Hormones and Metabolic Components in Patients With Obesity

Study Overview
=================
Brief Summary
-----------------
This study collected clinical data of obese patients with euthyroid function, including age, gender, height, weight, BMI, waist circumference, blood pressure, fasting blood sugar, blood sugar 2 hours after sugar load, fasting plasma high-density lipoprotein cholesterol, fasting three acyl glycerin, free iodine thyroid hormone (FT3) and free thyroid hormones (FT4), thyroid stimulating hormone (TSH), follow-up information and etc. Via analyzing the data, the investigators want to investigate the association between thyroid hormones (THs) and metabolic components in obese patients with euthyroid function and to present the cutoff values of THs in order to provide new information for the risk stratification of metabolic syndrome in obese patients with euthyroid function.

Official Title
-----------------
the Association Between Thyroid Hormones and Metabolic Components in Patients With Obesity

Conditions
-----------------
Obesity, Euthyroid Condition, Metabolic Syndrome

Intervention / Treatment
-----------------
* Other: no intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: 1) age ranged from 18-65 years old, 2) BMI over 27.9kg/m2,3)TSH，FT4, and FT3 within the range of 0.38-4.34mIU/L, 10.5-24.4mIU/L, and 2.8-6.3mIU/L, respectively. Exclusion Criteria: secondary cause of obesity such as hypothalamic obesity, Cushing syndrome, and hypophysis dysfunction, etc.,2)pregnancy or location, 3) severe heart, liver and kidney dysfunction

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| high TSH and high FT4<br>patients with high TSH and high FT4 | Other: no intervention<br>* This study collected data only without any intervention.<br>|
| high TSH and low FT4<br>patients with high TSH and low FT4 | Other: no intervention<br>* This study collected data only without any intervention.<br>|
| high TSH and high FT3<br>patients with high TSH and high FT3 | Other: no intervention<br>* This study collected data only without any intervention.<br>|
| high TSH and low FT3<br>patients with high TSH and low FT3 | Other: no intervention<br>* This study collected data only without any intervention.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| meet the criteria of metabolism in the 2017 Chinese guideline | Abdominal obesity (or central obesity), male abdominal circumference ≥90cm, female abdominal circumference ≥85 cm; Hypertension, those who have been diagnosed with hypertension and are in treatment and (or) blood pressure ≥130/85mmHg (1mmHg = 0.133kPa); Hyperglycemia, those who have been diagnosed with diabetes and are treated and (or) fasting blood glucose ≥6.1mmol/L or 2h blood glucose ≥7.8mmol/L after glucose load; Fasting high-density lipoprotein cholesterol (HDL-C) <1.04mmol/L; Fasting triacylglycerol ≥1.70mmol/L. | 2015-2020 | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| high uric acid | female patients with uric acid over 360 umol/L and male female patients with uric acid over 420 umol/L | 2015-2020 | 
| FBG≥6.1mmol/L | patients with fasting blood glucose 6.1mmol/L or more. | 2015-2020 | 
| BG120≥7.8mmol/L | patients with 2 hour blood glucose 7.8mmol/L or more. | 2015-2020 | 
| FINS≥24.9 pmol/ml | patients with fasting insulin 24.9 pmol/ml or more. | 2015-2020 | 
| FCP≥4.4nmol/L | patients with fasting C-peptide 4.4nmol/L or more. | 2015-2020 |