Mechanical Cardiopulmonary Resuscitation During Treatment of Acute Respiratory Failure Through Extracorporeal Membrane Oxygenation.

Study Overview
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Brief Summary
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In-hospital cardiovascular arrest is associated with poor outcome despite prompt treatment and optimal on-site resources. The population of patients treated by venovenous extracorporeal membrane oxygenation (vv-ECMO) due to pulmonary failure is a very challenging group of patients. To date, the frequency, causes and outcome of cardiovascular arrest in these patients have not been studied. We are aiming to conduct a retrospective observational study of all vv-ECMO patients treated at our ARDS centre.

Official Title
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Mechanical Cardiopulmonary Resuscitation During Treatment of Acute Respiratory Failure Through Extracorporeal Membrane Oxygenation.

Conditions
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Cardiovascular Resuscitation, Venovenous Extracorporeal Membrane Oxygenation

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients treated with veno-venous extracorporeal membrane oxygenation (vv-ECMO) due to respiratory failure during acute respiratory distress syndrome (ARDS). Exclusion Criteria: Patients treated with veno-arterial extracorporeal membrane oxygenation (va-ECMO)

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 80 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| cardiopulmonary resuscitation during treatment with extracorporeal membrane oxygenation<br>Patients treated with venovenous extracorporeal membrane oxygenation (vv-ECMO) for acute respiratory distress syndrome (ARDS) during the retrospective observation period who required mechanical cardiovascular resuscitation (CPR) during their treatment. | |
| Treatment with extracorporeal membrane oxygenation without resuscitation<br>Patients treated with venovenous extracorporeal membrane oxygenation (vv-ECMO) for acute respiratory distress syndrome (ARDS) without the need for cardiovascular resuscitation during the retrospective observation period. | |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Survival of mechanical cardiovascular resuscitation | Survival of mechanical cardiovascular resuscitation | During the intensive care stay ( usually between 2 and 8 weeks) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Incidence of cardiovascular resuscitation i | Incidence of cardiovascular resuscitation in patients treated with venovenous extracorporeal membrane oxygenation. | During the observation period 2019-2022 | 
| Complications of resuscitation treatments | Complications of cardiovascular resuscitation in patients treated with venovenous extracorporeal membrane oxygenation | During the intensive care stay ( usually between 2 and 8 weeks) |