linjc16/ctgov huggingface dataset:
Impedance Threshold Device Tilt Study

Study Overview
=================
Brief Summary
-----------------
This study will see if a special piece of equipment can help burn patients who have been in bed for a long time to get out of bed without feeling dizzy or faint.

Detailed Description
-----------------
To measure stroke volume, cardiac output, arterial blood pressure and cerebral blood flow velocity in human patients while they undergo exposure to head-up tilt that is designed to test their tolerance to an orthostatic challenge.

Official Title
-----------------
An Evaluation of an Impedance Threshold Device (ITD) to Improve Hemodynamic Function During Orthostatic Challenge in Burn Patients

Conditions
-----------------
Orthostatic Hypotension

Intervention / Treatment
-----------------
* Device: Impedance threshold device


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Military or civilian males or females between the ages of 18-65 years Burn injury with at least one unburned finger for Portapres measurement Minimum of 96 hours bedrest or physician directive to tilt Exclusion Criteria: Age < 18 and > 65 years Facial burns when application of ITD device would cause further trauma Medical monitoring devices that preclude the use of the ITD Signs of cardiac abnormalities, autonomic dysfunction Chronic obstructive pulmonary disease (COPD), or any other respiratory limitations (ventilator dependent, intubated, tracheostomy) limiting use of ITD History of pre-syncopal/syncopal episodes or orthostatic hypotension History of atherosclerotic coronary heart disease Patients taking any kind of cardiovascular pressor medications Inability to obtain a Portapres pulse wave validated by blood pressure cuff with +/- 5mmHg diastolic blood pressure Unable to provide informed consent for self

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Device: Impedance threshold device|nan|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Inspiratory impedance during passive upright tilt will prevent orthostatic hypotension. |  | 1 hour | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
inspiratory impedance threshold device, blood pressure regulation, head-up tilt test, tilt table testing, burn injury, Burns
Effects of Physical Training and Nutrition Education on Adipocytokines in Severely Obese Teenagers

Study Overview
=================
Brief Summary
-----------------
Obesity is now becoming significantly prevalent of an environment characterized by easily available calorics foods combined with sedentary lifestyles. Moreover, it has been demonstrated that obesity is associated with metabolic complications such as disturbed adipocytokines, hormones secreted by adipose tissue. Given these observations, the purpose of this study is to assess the effects of a lifestyle intervention focused on various physical activities and nutrition education on adipocytokines hormones, in severely obese teenagers.

Conditions
-----------------
Healthy, Obesity

Intervention / Treatment
-----------------
* Behavioral: obesity lifestyle intervention


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: to be aged from 12 to 17 to have a body mass index > 97 percentile for age and gender Exclusion criteria: systemic disease endocrine disorder syndromic obesity subjects receiving medication with a history of recent intercurrent illness

Ages Eligible for Study
-----------------
Minimum Age: 12 Years
Maximum Age: 17 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Intervention/Treatment |
| --- |
|Behavioral: obesity lifestyle intervention|physical activity 5 times per week + nutrition education|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Adipocytokines (leptin, adiponectin, ghrelin, PAI-1, resistin), based on subject's arterialized capillary blood samples. |  | during a lifestyle intervention of 9 months | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Body weight, body mass index, waist and hip circumference |  | during a lifestyle intervention of 9 months | 
| Body composition, calculated by a multifrequency bioelectric impedance |  | during a lifestyle intervention of 9 months | 
| Glycemia and lipids profile, based on subject's arterialized capillary blood samples analysis. |  | during a lifestyle intervention of 9 months | 
| Insulin resistance, calculated according to the formula of homeostasis model assessment |  | during a lifestyle intervention of 9 months | 
| Systolic and diastolic blood pressure, measured in millimeters of mercury at the level of the left brachial artery, using an automatic blood pressure monitor. |  | during a lifestyle intervention of 9 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
childhood obesity, adipocytokines, physical exercise, nutrition education
Physiological Responses to Maximal 4-s Sprint Interval Cycling

Study Overview
=================
Brief Summary
-----------------
The optimal recovery duration depends on the intensity of exercise and in the present study the intensity was maximal power for 4-s while cycling an 'Inertial Load' ergometer (ILE). Recovery duration of 15, 30 and 45-s were given between 30 successive sprints.

Detailed Description
-----------------
All subjects completed an informed consent for this study that was approved by the Institutional Review Board of the University of Texas at Austin. Study Overview. A randomized, cross-over experimental design was conducted. Each participant visited the laboratory on four occasions which were separated by two to five days. Measurement of body mass, familiarization with experimental procedures and cycling peak oxygen consumption test (VO2peak) were performed on the first visit. Participants took part in inertial-load exercise (ILE) on the remaining test days. On each separate session, a different inter-sprint recovery duration was employed (i.e. 15, 30 or 45-s). Cycling power output, pulmonary gas exchange, vastus lateralis de-oxygenation status, heart rate and blood lactate were measured.

Official Title
-----------------
Physiological Responses to Maximal 4-s Sprint Interval Cycling Using Inertial Loading: the Influence of Inter-sprint Recovery Duration

Conditions
-----------------
Exercise, Cardiovascular Function, Fatigue, Muscular Power

Intervention / Treatment
-----------------
* Other: inertial-load exercise (ILE)


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: healthy participants Exclusion Criteria: unhealthy

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 40 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Interventional Model Description: Repeated measures, cross-over
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Recovery duration 15 seconds<br>Resting for 15 sec | Other: inertial-load exercise (ILE)<br>* Length of time between exercise bouts<br>|
| Experimental: Recovery duration 30 seconds<br>Resting for 30 sec | Other: inertial-load exercise (ILE)<br>* Length of time between exercise bouts<br>|
| Experimental: Recovery duration 45 seconds<br>Resting for 45 sec | Other: inertial-load exercise (ILE)<br>* Length of time between exercise bouts<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| maximal leg power |  | 10 min |
BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success

Study Overview
=================
Brief Summary
-----------------
The investigators want to compeer BHCG levels after Methotrexate ( MTX). treatment for Ectopic pregnancy in days 4 and 7 after MTX. to day 10 . The hypothesis is that BHCG level in day 10 is the best indicator for treatment success , superior to day 4 and 7 . According to the investigators impression BHCG level rises in days 4 and 7 due to destruction of the trophoblast tissue , and only day 10 is an indicator for treatment success

Official Title
-----------------
BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success

Conditions
-----------------
Ectopic Pregnancy

Intervention / Treatment
-----------------
* Drug: Methotrexate


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with ectopic pregnancy healthy hemodynamic stable first ectopic Exclusion Criteria: hemodynamic non-stable abnormal liver or kidney function allergy reaction to MTX

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 50 Years

Sexes Eligible for Study
-----------------
Female

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: MTX , treatment outcome<br>patient receiving MTX. in a dosage of 50 mg/m^2 , IM , in single dose | Drug: Methotrexate<br>* 50 mg / meter squer Intramuscular (IM) MTX.<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| To measure the change of levels of BHCG in patients receiving Methotrexate for treatment of ectopic pregnancy in days 4, 7, and 10 post treatment | To compeer levels of BHCG in days 4 and 7 to day 10 after injection of MTX. for Ectopic pregnancy treatment | the change of levels in days 4, 7, and 10 post MTX injection | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
MTX, Ectopic pregnancy, medical treatment
Endolumenal Partial Myotomy for Esophageal Motility Disorders

Study Overview
=================
Brief Summary
-----------------
Achalasia and esophageal spasm are primary esophageal motility disorders where the lower esophageal sphincter fails to relax in response to swallowing with no well understood underlying cause. Surgical myotomy represents an appropriate therapeutic option. The purpose of this study is to evaluate flexible endoscopic myotomy a novel therapeutic approach to overcome the need for invasive surgery.

Detailed Description
-----------------
In this study, the investigators propose the use of a recent endolumenal technique for partial myotomy in patients suffering from primary esophageal motility disorders. Under general anesthesia patients will have upper endoscopy. Submucosal injection and mucosal incision is created for entry into the submucosal space. A submucosal tunnel is then created using a needle knife or blunt dissection as appropriate. Dissection will continue distally beyond the lower esophageal sphincter. The inner circular muscle fibers will then be divided to achieve an adequate myotomy length. The mucosal entry is then closed appropriately. Results will be compared to historical data of conventional Heller myotomies.

Official Title
-----------------
Endoscopic Submucosal Tunnel Dissection for Endolumenal Partial Myotomy of the Lower Esophageal Sphincter for Atypical Primary Motility Disorders Such as Achalasia and Esophageal Spasm

Conditions
-----------------
Esophageal Motility Disorders

Intervention / Treatment
-----------------
* Procedure: Per oral endolumenal myotomy


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Candidate for elective Heller myotomy Ability to undergo general anesthesia Ability to give informed consent Exclusion Criteria: Previous mediastinal or esophageal surgery Contraindications for EGD

Ages Eligible for Study
-----------------
Minimum Age: 18 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Intervention/Treatment |
| --- |
|Procedure: Per oral endolumenal myotomy|flexible endoscopic submucosal esophageal partial myotomy|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Esophageal Function Tests | upper endoscopy, barium swallow, esophageal manometry,ph Test | 6 month | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Quality of life score | quality of life questionaire | 6 months | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
endolumenal myotomy, per oral endoscopic myotomy
Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy

Study Overview
=================
Brief Summary
-----------------
Patients suffering from congenital fourth cranial nerve palsy may have misalignment of jaws as well as teeth due to head tilt in childhood.

Detailed Description
-----------------
Measurement of teeth and jaw parameters in patients suffering from congenital fourth cranial nerve palsy compared to patients without fourth cranial nerve palsy.

Official Title
-----------------
Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy

Conditions
-----------------
Fourth Cranial Nerve Palsy

Intervention / Treatment
-----------------
* Other: teeth molding


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: unilateral congenital fourth nerve palsy natural teeth occlusion age > 18 years Exclusion Criteria: bilateral fourth nerve palsy no natural teeth occlusion

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| controls<br>teeth molding in subjects without congenital fourth nerve palsy | Other: teeth molding<br>* teeth molding in patients suffering from congenital fourth nerve palsy<br>|
| congenital fourth nerve palsy<br>teeth molding in patients suffering from congenital fourth nerve palsy | Other: teeth molding<br>* teeth molding in patients suffering from congenital fourth nerve palsy<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| angle between teeth positions from upper and lower jaw | The angle between teeth positions from upper and lower jaw will be measured using teeth molding. | 3 to 6 months after recruitment | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
teeth position, jaw alignment
Brassiere Brow Suture and Internal Browpexy

Study Overview
=================
Brief Summary
-----------------
Brow ptosis is a common problem. internal browbexy and brassier suture are common surgical approach

Detailed Description
-----------------
upper eye transcutaneous blepharoplasty then combined browbexy and brassier suture are done

Official Title
-----------------
Brassiere Brow Suture and Internal Browpexy as Disjunctive Upper Eyelid Blepharoplasty

Conditions
-----------------
Eyelid Diseases

Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: brow ptosis and dermatochalasis Exclusion Criteria: eyelid diseases and previous surgery

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| surgical<br>internal browbexy and brassier suture were done after blepharoplasty | |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| global aesthetic scale | calculate scale score from score 1 exceptional improvement to 5 worsening patient | 1 year | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
blepharoplasty, browbexy
Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications

Study Overview
=================
Brief Summary
-----------------
Respiratory complications represent the second most frequent type of postoperative complications with an incidence estimated to range from 2.0% to 7.9% It has been shown that intra-operative protective ventilation is associated with a reduced risk of respiratory complications. The effects of intra-operative inspiratory oxygen fraction (FiO2) remain to be investigated. In this study, the investigators aim to investigate the association between intra-operative FiO2 and respiratory complication as well as surgical site infection and ICU admission in patients undergoing non-cardiothoracic surgery. The investigators primary hypothesis is that high intra-operative FiO2 increases the risk of postoperative respiratory complications independent of predefined risk factors.

Official Title
-----------------
Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications

Conditions
-----------------
Respiratory Failure, Acute Respiratory Failure Requiring Intubation, Pulmonary Edema, Pneumonia, Surgical Wound Infection, Mortality

Intervention / Treatment
-----------------
* Drug: Inspiratory oxygen


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Non-cardiothoracic surgery at Massachusetts General Hospital between January 2007 and August 2015 Tracheally intubated at the beginning of the procedure and extubated at the end of the procedure above18 years of age Exclusion Criteria: Missing information regarding main characteristics or the exposure variable

Ages Eligible for Study
-----------------
Minimum Age: 18 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Patients undergoing surgery<br>All non-cardiothoracic surgical patients aged 18 years or above receiving general anesthesia at Massachusetts General Hospital between January 2007 and August 2014. | Drug: Inspiratory oxygen<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative respiratory complications |  | 7 days after surgery | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Postoperative reintubation |  | 7 days after surgery | 
| Postoperative respiratory failure |  | 7 days after surgery | 
| Postoperative pneumonia |  | 7 days after surgery | 
| Postoperative pulmonary edema |  | 7 days after surgery | 
| Postoperative surgical site infection |  | 21 days after surgery | 
| Postoperative admission to the intensive care unit |  | 7 days after surgery | 
| Postoperative mortality |  | 7 days after surgery | 
| Postoperative mortality |  | 30 days after surgery | 
| Postoperative length of stay |  | 360 days after surgery |
Comparison of ACL Reconstruction With Stump Preservation and Stump Resection

Study Overview
=================
Brief Summary
-----------------
To assess the clinical outcome in patients who had ACL reconstruction with preservation of the remnant and compare it with patients in whom the stump was resected

Detailed Description
-----------------
100 patients are subjected to ACL reconstruction. Half of them had ACL reconstruction with Stump preservation and the other half had ACL reconstruction with stump resection. The clinical outcome in both groups is assessed and compared

Official Title
-----------------
Does Stump-Preserving Anterior Cruciate Ligament Reconstruction Provide Better Functional Outcomes? A Prospective Comparative Study.

Conditions
-----------------
Knee Ligament Injury

Intervention / Treatment
-----------------
* Procedure: ACL reconstruction


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: patients with torn ACL within 6 months Exclusion Criteria: Old ACL injury Multi-ligamentous knee injuries Mal-alignments

Accepts Healthy Volunteers
-----------------
No

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: ACL reconstruction with stump preservation<br> | Procedure: ACL reconstruction<br>* Use of hamstring tendons graft to replace the torn ACL and being passed and fixed through the femoral and tibial sides<br>|
| Active Comparator: ACL reconstruction with stump resection<br> | Procedure: ACL reconstruction<br>* Use of hamstring tendons graft to replace the torn ACL and being passed and fixed through the femoral and tibial sides<br>|

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Knee stability | KT-1000 Arthrometer | after 2 years | 
| Knee proprioception | Passive angle reproduction test | after 2 years | 
| Lysholm score |  | After 2 years | 
| Tegner activity score |  | after 2 years | 
| IKDC score |  | after 2 years | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Anterior cruciate ligament reconstruction, tibial stump, stump preservation, knee proprioception.