Brain Function Predictors And Outcome Of Weight Loss And Weight Loss Maintenance

Study Overview
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Brief Summary
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By doing this study, researchers hope to learn whether a person's motivation for food is different after he or she loses weight, and if imaging techniques such as fMRI can be used to predict whether the person will maintain that weight loss over time.

Official Title
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Brain Function Predictors And Outcome Of Weight Loss And Weight Loss Maintenance

Conditions
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Obesity

Intervention / Treatment
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* Other: Diet Intervention
* Other: Assessments and Diet Intake


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: BMI equal to or greater than 30 kg/m2 or 18 to 24.9 declaration they do not have plans to move out of the Greater Kansas City area for at least 1 year willingness to be randomized Individuals undergoing weight loss will have to present written approval from a licensed physician that they are healthy enough to participate in a program of moderate diet restriction and moderate physical activity. Exclusion Criteria: Participation in a research project involving weight loss or PA in the previous 6 months, as these proximal experiences may impact the results of this study. Subjects who smoke Subjects who use special diets (i.e. vegetarian, Adkins, etc.), use medications that affect metabolism (i.e. thyroid, beta blockers), use medications that affect appetite (i.e. Meridia) or cannot exercise (i.e. walk). Exhibit signs of eating disorders, restraint, depression Participant has any metabolic disease that would affect energy balance (e.g. diabetes mellitus or hypothyroidism). Individuals who report being pregnant during the previous 6 months, are lactating, or planned pregnancy within 12 months Individuals who are not weight stable (± 4.5kg) within the previous 3 months or have more than 500 kcal/wk of planned physical activity Serious medical risk such as type 1 diabetes, cancer, recent cardiac event (i.e. heart attack, angioplasty, etc.)

Ages Eligible for Study
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Minimum Age: 21 Years
Maximum Age: 55 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Healthy Weight Control Group<br>Subjects will complete the Assessments, Diet Intake, and MRI portions of the study | Other: Assessments and Diet Intake<br> <br> |
| Active Comparator: Dieting Group<br>Subjects will complete the Assessments, Diet Intake, and MRI portions of the study and will be given the weight loss and weight maintenance diets, and will attend weekly behavioral meetings | Other: Diet Intervention<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Differences in brain activation to visual food cues | differences will be measured by scanning subjects with fMRI and measuring changes in different regions of the brain. | Change from Baseline to 3 Months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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weight loss, diet