Appetite Regulation and Mycoprotein

Study Overview
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Brief Summary
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The purpose of this study is to investigate the effect of eating various levels of mycoprotein (Quorn) on feelings of appetite, energy intake and levels of gut hormones in overweight volunteers.

Detailed Description
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Owing to its relatively high protein and fibre content, mycoprotein presents an attractive food product to improve appetite regulation and postprandial glycaemic and insulin responses in overweight and obese individuals at risk of developing T2DM

Official Title
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Appetite Regulation and Mycoprotein

Conditions
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Appetite, Energy Intake

Intervention / Treatment
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* Dietary Supplement: mycoprotein
* Dietary Supplement: control protein


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Males and females between the ages of 18 and 65 body mass index (BMI) 25-32kg/m2 Weight stable over the past 6 months No known major illness or eating disorder nor on any medication that may impact on appetite or hormone levels. No paracetamol or other analgesic in the previous 48 hours A score of <2.5 in the Dutch Eating Behaviour Questionnaire (DEBQ) A score of <2 in the SCOFF questionnaire Exclusion Criteria: Persons outside the age and BMI ranges stated above Pregnant and lactating women Weight variation of greater than 5% in the last 6 months Any diagnosed major illness Any paracetamol or analgesic intake in the last 48 hours Diagnosed eating disorder Allergy to mycoprotein or mushrooms Regular consumption of Quorn products Dislike of any of the test foods or drinks A score of >2.5 in the Dutch Eating Behaviour questionnaire A score of 2 or more in the SCOFF questionaire

Ages Eligible for Study
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Minimum Age: 18 Years
Maximum Age: 65 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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Accepts Healthy Volunteers

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Basic Science
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: mycoprotein<br>3 levels of mycoprotein will be consumed | Dietary Supplement: mycoprotein<br> <br> |
| Active Comparator: control protein<br>3 levels of a control protein will be consumed | Dietary Supplement: control protein<br> <br> |

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Energy intake at ad-libitum meal | Energy intake will be assessed during an ad-libitum meal at 180 minutes at the end of each study visit. Participants will be offered a meal in excess and asked to eat until they feel comfortably full. The meal will be weighed before and after consumption and energy intake will be calculated from the manufacturer's reported nutritional composition. | upon completion of all participants, expected timeframe: 2 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Glucagon-like peptide-1 (GLP-1) | Plasma glucagon-like peptide-1 (GLP-1) concentrations will be measured by radioimmunoassay (RIA) at the end of the study | upon completion of all participants, expected at 2 years | 
| peptide tyrosine-tyrosine (PYY) levels | Plasma peptide tyrosine-tyrosine (PYY) concentrations will be measured by radioimmunoassay (RIA) at the end of the study | upon completion of all participants, expected at 2 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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appetite, overweight, energy intake, obesity, gut hormones