Volume Parameters vs Flow Parameters in Assessment of Reversibility in Chronic Obstructive Pulmonary Disease

Study Overview
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Brief Summary
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Assess the differences between flow and volume responses after bronchodilator reversibility testing in patients over different clinical chronic obstructive pulmonary disease stages (GOLD stage I to GOLD stage IV). Study the Correlation between the bronchodilator response and the severity of the disease.

Detailed Description
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chronic obstructive pulmonary disease is a common preventable and treatable disease characterized by persistent airflow limitation that is usually progressive. The diagnosis requires an evidence of obstructive pattern by spirometry measured before and after bronchodilators. The degree of reversibility of airflow obstruction differs between patients, and does not predict the response to bronchodilator therapy. It can be seen in terms of forced vital capacity (FVC) or forced expiratory volume in the first second (FEV1),or Inspiratory capacity (IC) or residual volume (RV).

Official Title
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Volume Parameters Vs Flow Parameters In Assessment Of Reversibility In Stable Chronic Obstructive Pulmonary Disease Patients

Conditions
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Chronic Obstructive Pulmonary Disease

Intervention / Treatment
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* Diagnostic Test: Whole body plethysmography


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients Clinical diagnosis of Chronic Obstructive Pulmonary Disease Must be able to do pulmonary function test Age more than 40 years Stable Chronic Obstructive Pulmonary Disease patients Exclusion Criteria: Any patients with a diagnosis of: Bronchial asthma Bronchiectasis Respiratory failure Decompensated core pulmonale Chronic Obstructive Pulmonary Disease combined with any other respiratory disease

Ages Eligible for Study
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Minimum Age: 40 Years
Maximum Age: 60 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Diagnostic
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Whole body plethysmography<br> | Diagnostic Test: Whole body plethysmography<br>* Whole body plethysmography : measure lung volumes Spirometry : to assess severity of chronic obstructive pulmonary disease also reversibility testing<br>* Other names: Plain chest radiograph;|
| Active Comparator: spirometery<br> | Diagnostic Test: Whole body plethysmography<br>* Whole body plethysmography : measure lung volumes Spirometry : to assess severity of chronic obstructive pulmonary disease also reversibility testing<br>* Other names: Plain chest radiograph;|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Assess the response pattern to inhaled short acting B2 agonist | Assess the response pattern to inhaled short acting B2 agonist through measuring flow and volume parameters to define the differences between volumes responders and flow responders | twice per day one before inhaled short acting B2 agonist and one after 10 minutes from inhaled short acting B2 agonist for average of 2 year |