Risk Evaluation and Management in Heart Failure

Study Overview
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Brief Summary
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This is an prospective study conducted in a Chinese heart failure population. The study investigates the effects of cardiovascular disease risk factors such as lifestyle behaviors,biomarkers and intermediate diseases on heart failure prognosis.

Detailed Description
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Heart failure is the main cause of cardiovascular death. The primary goal of this study is to estimate the association of lifestyle behavior (e.g., alcohol, tea and coffee consumption, sedentary behavior, smoking habit, sleep disorder and physical activity), intermediate conditions (e.g., hypertension, diabetes and dyslipidemia), genetic risk factors and circulating biomarkers with heart failure prognosis. Another goal is to improve the health status and reduce cardiovascular events and death for heart failure patients via patient education, disease monitoring and medication titration. This study planned to consecutively enroll 1,000 heart failure patients fulfilling the inclusion criteria. Each participants will be followed up for at least 5 years. The study endpoints, all-cause mortality and cardiovascular events, will be identified by directly contacting participants during the follow-up surveys, checking pertinent medical records and discharge lists from the hospitals, or checking death certificates from local vital statistics offices. The Cox proportional hazard model will be used to estimate the risk factors for health outcomes in heart failure patients.

Official Title
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Risk Evaluation and Management in Heart Failure

Conditions
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Heart Failure, Risk Factor, Cardiovascular

Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: aged 18 and above inpatient with one of the following clinical situations: congestive heart failure (pulmonary edema,pulmonary congestion or peripheral edema) cardiogenic shock Insufficient high output cardiac with impaired cardiac function diagnosed by echocardiography able to provide informed consent Exclusion Criteria: expressed refusal to participate in the baseline investigation or follow-up visits Severe co-morbidity associated with a reduction in life expectancy of less than 12 months

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| All-cause mortality |  | 10 years | 
| A composite of cardiovascular events | A composite of myocardial infarction, revascularization, stroke, rehospitalization due to heart failure and cardiovascular death | 10 years | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| myocardial infarction |  | 10 years | 
| revascularization |  | 10 years | 
| stroke |  | 10 years | 
| rehospitalization due to heart failure |  | 10 years | 
| cardiovascular death |  | 10 years | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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heart failure, risk factor, cardiovascular disease, lifestyle behavior