Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease

Study Overview
=================
Brief Summary
-----------------
In AD (Alzheimer disease), the anatomic correlates of attention disorders (as evaluated by motor slowing) have not been thoroughly characterized.

Official Title
-----------------
Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease

Conditions
-----------------
Alzheimer Disease

Intervention / Treatment
-----------------
* Device: Brain MRI
* Other: neuropsychological evaluation
* Biological: Blood


Participation Criteria
=================
Eligibility Criteria
-----------------
Inclusion Criteria: Patients Age between 40 and 85 French mother tongue Consulting at the Amiens Memory Resource and Research Centre (CMRR) for: MCI, according to Albert et al.'s criteria (Albert et al., 2011) Mild dementia (MMSE>20) due to AD, according to McKhann's criteria (McKhann et al., 2011). Mild dementia due to LBD, according to McKeith et al.'s criteria (McKeith et al., 2005). Mild dementia due to FTLD, according to Rascovsky et al.'s criteria (Rascovsky et al., 2011). Social security coverage Healthy controls Healthy age and gender matched volunteers will be recruited into the study from the general population. Exclusion Criteria: Reading or writing difficulties related to a learning disorder or illiteracy. A medical history with a potentially significant impact on cognition (non-corrected thyroid disorders or heart failure): NYHA stage IV dyspnoea. respiratory impairment requiring oxygen therapy. liver impairment. kidney failure, progressing neoplastic disease, or past or present alcohol abuse. Past or present neurological disorders other than those having prompted consultation in the Memory Clinic: stroke. meningitis or encephalitis. severe head injury. sensorimotor impairments (sensory, proprioceptive, cerebellar and visual impairments). epilepsy (requiring ongoing treatment), psychiatric disorders (other than treated depression). treatment with psychotropic medications (other than anxiolytics or antidepressant withdrawn or initiated in the previous month). Patients with parkinsonian syndrome were examined in the on-drug state. Impossibility to perform a neuropsychological evaluation or brain MRI. Withdrawal from the study at any time, if desired. Pregnancy Contra-indication to MRI: nerve stimulators cochlear implants ferromagnetic foreign bodies close to nervous structures in the eye or brain cerebral shunts dental appliances Legal guardianship or incarceration.

Ages Eligible for Study
-----------------
Minimum Age: 40 Years
Maximum Age: 85 Years

Sexes Eligible for Study
-----------------
All

Accepts Healthy Volunteers
-----------------
Accepts Healthy Volunteers

Study Plan
=================
How is the study designed?
-----------------

Design Details

Primary Purpose: Basic Science
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Alzheimer disease<br>Alzheimer disease patients Brain MRI (Magnetic Resonance Imaging) Blood neuropsychological evaluation | Device: Brain MRI<br> <br> Other: neuropsychological evaluation<br> <br> Biological: Blood<br> <br> |
| Active Comparator: control<br>Healthy age- and gender-matched volunteers will be recruited into the study from the general population. Brain MRI (Magnetic Resonance Imaging) Blood neuropsychological evaluation | Device: Brain MRI<br> <br> Other: neuropsychological evaluation<br> <br> Biological: Blood<br> <br> |

What is the study measuring?
-----------------
Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| median SRT (simple reaction time) to a stimulus (in milliseconds) |  | Day 0 | 

 Terms related to the study
=================
Keywords Provided by Centre Hospitalier Valida
-----------------
Motor slowing