Comparison of Articaine and Prilocaine for Extraction of Maxillary Teeth

Study Overview
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Brief Summary
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Ninety-five patients, aged between 16 and 70 years old, were included in this study. Patients were divided into two groups. Group one received Articaine 4% with 1:00.000 Adrenalines. Group two received Prilocaine with 3% Felypressin (0.03 I.U. per ml). Onset time of anaesthesia was objectively evaluated by using electronic pulp testing.

Detailed Description
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85 patients in this study had successful local anaesthetic followed by extraction within the study duration time (10 minutes). However, there were six patients with failure anaesthesia (5 in prilocaine group and 1 in articaine group). By application Person's Chi-square test (x2), there were no significant differences in the number of the episodes of the anaesthetic success between articaine and prilocaine groups at time intervals (P-value = 0.5). T- test showed there have been no important variations within the mean onset time of anaesthesia for articaine and prilocaine buccal infiltrations (P-value =0.1).

Official Title
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Does Articaine, Rather Than Prilocaine, Increase the Success Rate of Anaesthesia for Extraction of Maxillary Teeth

Conditions
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Overcoming the Failure of Anaesthesia, Maxillary Teeth, Dental Extraction

Intervention / Treatment
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* Drug: Articaine 4%
* Drug: Prilocain 3%
* Drug: Adrenalin
* Drug: Felypressin


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patients have one or two upper teeth for extraction, subject tooth or its adjacent must be vital, healthy patient or patient with mild systemic diseases (class I or II according to American Society of Anesthesiology). Exclusion Criteria: Patients excluded from this study if they have allergy to local anaesthetic agents or need surgical, or multiple teeth extraction.

Ages Eligible for Study
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Minimum Age: 16 Years
Maximum Age: 70 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Allocation: Randomized
Intervention Model: Parallel Assignment
Interventional Model Description: double blinded randomised trial
Masking: Single


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Active Comparator: Articaine 4% with 1:00.000 Adrenaline<br>if the patient was in articaine group, buccal infiltration technique was applied by inserting a short needle at the height of buccal sulcus along the long axis of the subject tooth for extraction. | Drug: Articaine 4%<br>* Articaine 4% is dental local anaesthetic agent<br>Drug: Adrenalin<br>* adrenaline is a vasoconstrictor<br>|
| Active Comparator: Prilocaine with 3% Felypressin (0.03 I.U. per ml)<br>if the patient was in prelocaine group, buccal infiltration technique was applied by inserting a short needle at the height of buccal sulcus along the long axis of the subject tooth for extraction. | Drug: Prilocain 3%<br>* prilocaine is dental local anaesthetic agent<br>Drug: Felypressin<br>* Felypressin is a vasoconstrictor<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Does articaine, rather than prilocaine, increase the success rate of anaesthesia for extraction of maxillary teeth | to compare the anaesthetic performances of 3% prilocaine (the safest local anaesthetic) with 4 % articaine (the local anaesthetic with fastest onset time of action) when used for maxillary teeth extraction | 6 months | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Carticaine, dental extraction, injections, prilocaine