Exposure Initializes Therapy - Treatment Of Homebound Patients Extended

Study Overview
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Brief Summary
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Cognitive behavioral treatment of homebound patients with severe agoraphobia.

Detailed Description
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Homebound patients with severe agoraphobia are treated with an exposure focussed cognitive behavioral therapy. The treatment begins at home. With a quick onset of guided exposure, patients get the possibility to develope the capability to reach the regular Treatment Location on their own very rapidly.

Official Title
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Exposure Initializes Therapy - Treatment Of Homebound Patients Extended

Conditions
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Agoraphobia

Intervention / Treatment
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* Behavioral: cognitive behavioral therapy


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: agoraphobia with/without Panic disorder Exclusion Criteria: psychotic disorders bipolar disorders acute substance dependency

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Accepts Healthy Volunteers
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No

Study Plan
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How is the study designed?
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Design Details

Primary Purpose: Treatment
Intervention Model: Single Group Assignment
Interventional Model Description: repeated measure of a single group
Masking: None (Open Label)


Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Experimental: Cognitive Behavioral Therapy<br>Manualized Cognitive Behavioral Therapy starting at the patients' home. | Behavioral: cognitive behavioral therapy<br>* cognitive behavioral therapy with Focus on guided exposure<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| MI | Mobility Inventory | Change from baseline to 4th psychotherapy session (+42 days) and change from baseline to the 9th psychotherapy session (+60 days) and change from baseline to follow up (+98 days) | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| AKF | Angst-Kontroll-Fragebogen (anxiety control) | Change from baseline to 4th psychotherapy session (+42 days) and change from baseline to the 9th psychotherapy session (+60 days) and change from baseline to follow up (+98 days) | 
| ASI | Angstsensitivität (anxiety sensitivity) | Change from baseline to 4th psychotherapy session (+42 days) and change from baseline to the 9th psychotherapy session (+60 days) and change from baseline to follow up (+98 days) | 
| NEO-FFI | Persönlichkeitsfragebogen (personality inventory) | Change from baseline to 4th psychotherapy session (+42 days) and change from baseline to the 9th psychotherapy session (+60 days) and change from baseline to follow up (+98 days) | 
| PSQ 20 | perceived stress questionnaire | Change from baseline to 4th psychotherapy session (+42 days) and change from baseline to the 9th psychotherapy session (+60 days) and change from baseline to follow up (+98 days) | 
| rs 13 | Resilienzskala (resilience scale) | Change from baseline to 4th psychotherapy session (+42 days) and change from baseline to the 9th psychotherapy session (+60 days) and change from baseline to follow up (+98 days) | 
| SWE | Selbstwirksamkeitsfragebogen (self-efficacy questionnaire) | Change from baseline to 4th psychotherapy session (+42 days) and change from baseline to the 9th psychotherapy session (+60 days) and change from baseline to follow up (+98 days) | 
| UI18 | Unsicherheitsintoleranz Fragebogen (intolerance of uncertainty questionnaire) | Change from baseline to 4th psychotherapy session (+42 days) and change from baseline to the 9th psychotherapy session (+60 days) and change from baseline to follow up (+98 days) | 
| EQ-5D | life quality questionnaire | Change from baseline to 4th psychotherapy session (+42 days) and change from baseline to the 9th psychotherapy session (+60 days) and change from baseline to follow up (+98 days) | 
| AAQ II | Acceptance and Action questionnaire | Change from baseline to 4th psychotherapy session (+42 days) and change from baseline to the 9th psychotherapy session (+60 days) and change from baseline to follow up (+98 days) | 
| ACQ | Agoraphobic cognition questionnaire | Change from baseline to 4th psychotherapy session (+42 days) and change from baseline to the 9th psychotherapy session (+60 days) and change from baseline to follow up (+98 days) | 
| BSQ | Bosy Sensation Questionnaire | Change from baseline to 4th psychotherapy session (+42 days) and change from baseline to the 9th psychotherapy session (+60 days) and change from baseline to follow up (+98 days) | 
| BDI II | Beck Depression inventory II | Change from baseline to 4th psychotherapy session (+42 days) and change from baseline to the 9th psychotherapy session (+60 days) and change from baseline to follow up (+98 days) | 
| alpha-amylase | daily profile of salivary alpha amylase | change from baseline to follow up (+98 days) | 
| cortisol | daily profile of salivary cortisol | change from baseline to follow up (+98 days) | 
| PAS | Panik- und Agoraphobie-Skala (Panic and agoraphobia scale) | Change from baseline to 4th psychotherapy session (+42 days) and change from baseline to the 9th psychotherapy session (+60 days) and change from baseline to follow up (+98 days) |