Impact of Sarcopenia Using an Easy Psoas Area Measurement

Study Overview
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Brief Summary
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The purpose of this study is to compare the post-operative course in patients suffering from sarcopenia who had colorectal surgery for cancer. Our primary outcome is the comparaison of the length of hospital stay in sarcopenic and non sarcopenic patients.

Detailed Description
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Sarcopenia is the loss of muscle mass that occurs usually with aging, but it may have multiple contributing factors, especially related to chronic diseases such as colorectal cancer. When present, sarcopenia is predictive of poor post-operative course. The identification of sarcopenia needs either the identification of low muscle strength, low muscle quantity/quality, or finally a low physical performance. Multiple clinical, biological or radiological tools were proposed. Our purpose is to compare the post-operative outcome of sarcopenic and non sarcopenic patients using a simple, available, reproducible and rapid radiological method, which will help the healthcare professionals to rapidly identify high risk patients for possible complicated and long post-operative course allowing them to take appropriate perioperative measures to reduce the risks.

Official Title
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Impact of Sarcopenia on Post-operative Course for Cancer Patients Operated of Colorectal Surgery Using a Simple Measurement Method of the Psoas Muscle Surface Area

Conditions
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Sarcopenia

Intervention / Treatment
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* Other: Colectomy with anastomosis of any type


Participation Criteria
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Eligibility Criteria
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Inclusion Criteria: Patient operated on for colectomy or proctectomy with restoration of continuity for colorectal cancer between 1 January 2020 and 31 December 2021 Patient who had a CT scan in the 2 months prior surgery Patient aged 18 years or older Exclusion Criteria: Patients with inflammatory bowel disease (Crohn disease, haemorrhagic rectocolitis) Patients with neuromuscular pathology affecting their mobility Patients who were diagnosed positif to SARS COV 2 before or during hospitalisation Patients who refuse the collection of their data

Ages Eligible for Study
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Minimum Age: 18 Years

Sexes Eligible for Study
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All

Study Plan
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How is the study designed?
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Arms and Interventions

| Participant Group/Arm | Intervention/Treatment |
| --- | --- |
| Colectomy with anastomosis of any type<br>Patient with colonic resection followed by ileocolic, or colo colic, or colorectal, or coloanal anastomosis for cancer by laparoscopy or laparotomy | Other: Colectomy with anastomosis of any type<br>* Patient with colonic resection followed by ileocolic, or colo colic, or colorectal, or coloanal anastomosis for cancer by laparoscopy or laparotomy<br>|

What is the study measuring?
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Primary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison of the average postoperative length of stay in sacopenic and non-sarcopenic patients | Comparison of the number of post-operative hospital days between the two groups | Until discharge from hospital, an average of 30 days | 

Secondary Outcome Measures

| Outcome Measure | Measure Description | Time Frame |
| --- | --- | --- |
| Comparison between complication rate in sarcopenic and non sarcopenic patients | Measurement of the complication rate according to the Clavien Dindo score (relevant score if greater than or equal to 2, considered severe complication if greater than or equal to 3) between the two groups | At the end of the 30 post-operative days | 
| Assessment of re-hospitalization rate between sarcopenic and non sarcopenic patients | Evaluation of the number of hospitalizations of more than 24 hours at 30 days after the operation between the two groups | At the end of the 30 post-operative days | 
| Comparison of the transfer rate to rehabilitation or nursing home center between sarcopenic and non sarcopenic patients | Evaluation of the number of transfer to rehabilitation or nursing home center at 30 days after the operation between the two groups | At the end of the 30 post-operative days | 
| Comparison of the length of stay in the rehabilitation center for sarcopenic and non sarcopenic transferred patients | Comparison of the number of hospital days for transferred patients between the two groups | At the end of the 30 post-operative days | 

 Terms related to the study
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Keywords Provided by Centre Hospitalier Valida
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Sarcopenia, colorectal neoplasm, colorectal surgery, psoas muscles